[Hardy-Weinberg equilibrium in genetic epidemiology].
Hardy-Weinberg equilibrium test is the base of genetic epidemiology. The new methods for Hardy-Weinberg equilibrium test involve: X chromosome-linked single nucleotide polymorphism Hardy-Weinberg test, inbreeding coefficient (F) test, an incomplete enumeration algorithm for an exact test of Hardy-Weinberg proportions with multiple alleles, and graphical tests for Hardy-Weinberg equilibrium based on the ternary plot. It is necessary to conduct Hardy-Weinberg equilibrium test in genetic epidemiology studies and adjust the associations as deviation of Hardy-Weinberg equilibrium occurs.
Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing 100083, China.
Hong
H
Liu
Yonghua
Y
Hu
D000465:Algorithms; D003241:Consanguinity; D005787:Gene Frequency; D050172:Genes, X-Linked; D005828:Genetics, Population; D006801:Humans; D017720:Molecular Epidemiology / Q000379:methods*; D020641:Polymorphism, Single Nucleotide