New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression.
T cell-directed therapies have become mainstays in the management of various autoimmune diseases and organ transplantation. The understanding of T cell biology has expanded greatly since the development of most agents currently in use. Here we discuss important recent discoveries pertaining to T helper cell differentiation, lineage commitment, and function. Within this context, we examine existing T cell-directed therapies, including new agents being evaluated in clinical and preclinical studies. We also use recent findings to speculate on novel targets.
Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. stewardtharpsm@mail.nih.gov
Scott M
SM
Steward-Tharp
Yun-jeong
YJ
Song
Richard M
RM
Siegel
John J
JJ
O'Shea
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D015551:Autoimmunity / Q000276:immunology; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D056747:Immunomodulation / Q000502:physiology*; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000627:therapeutic use; D007249:Inflammation / Q000276:immunology / Q000628:therapy*; D008954:Models, Biological; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000502:physiology*
D007166:Immunosuppressive Agents