Serum high-sensitivity C-reactive protein and heat shock protein 27 antibody titers in patients with stroke and 6-month prognosis.
Serum heat shock protein 27 immunoglobulin G (IgG) antibody titers (anti-HSP27) and high-sensitivity C-reactive protein (hsCRP) concentrations were measured in samples from 168 patients in the first 24 hours after the onset of stroke and 80 age-and sex-matched control participants. In patients with stroke, median serum anti-HSP27 titer was significantly higher than that of the control group (0.18 [0.14-0.28] vs 0.08 [0.04-0.12], P < .001). Median serum hsCRP concentration was also significantly higher in patients compared with the control group (11.43 [8.07-13.53] vs 3.23 [1.66-6.24], P < .001). Serum anti-HSP27 and hsCRP concentrations did not differ significantly among patients with different stroke types. Neither serum anti-HSP27 nor hsCRP levels predicted 6-month prognosis in the patients with stroke. We conclude that serum anti-HSP27 titers and hsCRP concentrations are elevated in patients with stroke but do not distinguish between stroke types or predict 6-month prognosis.
Department of Neurology, Mashhad University of Medical Sciences, Iran.
Mahmoud Reza
MR
Azarpazhooh
Naser
N
Mobarra
Syyed Mohammad Reza
SM
Parizadeh
Shima
S
Tavallaie
Mahsa
M
Bagheri
Amir Ali
AA
Rahsepar
Majid
M
Ghayour-Mobarhan
Amirhossein
A
Sahebkar
Gordon A A
GA
Ferns
D000906:Antibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D055551:HSP27 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D018709:Statistics, Nonparametric; D020521:Stroke / Q000097:blood*
D000906:Antibodies; D015415:Biomarkers; D055551:HSP27 Heat-Shock Proteins; D002097:C-Reactive Protein