Bacterial invasion: linking autophagy and innate immunity.
Crohn's disease is a chronic inflammatory bowel disorder that has been associated with polymorphisms in the genes encoding the pattern-recognition receptor NOD2 and the autophagic regulator ATG16L1. A new study demonstrates that NOD2 recruits ATG16L1 at bacterial entry sites, thereby bridging innate immunity and autophagy.
INSERM, U848, F-94805 Villejuif, France; Institut Gustave Roussy, F-94805 Villejuif, France.
Lorenzo
L
Galluzzi
Oliver
O
Kepp
Laurence
L
Zitvogel
Guido
G
Kroemer
D000818:Animals; D001343:Autophagy / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D000071183:Autophagy-Related Proteins; D001424:Bacterial Infections / Q000276:immunology* / Q000503:physiopathology*; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology; D003424:Crohn Disease / Q000235:genetics / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics / Q000502:physiology; D008954:Models, Biological; D009154:Mutation; D053473:Nod2 Signaling Adaptor Protein / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction
C518959:ATG16L1 protein, human; D000071183:Autophagy-Related Proteins; D002352:Carrier Proteins; C429018:NOD2 protein, human; D053473:Nod2 Signaling Adaptor Protein