Discovery of novel transcriptional and epigenetic targets in APL by global ChIP analyses: Emerging opportunity and challenge.
Identifying transcriptional program(s) deregulated by oncoproteins is key to understanding the molecular basis of the disease. In this issue of Cancer Cell, two studies by Martens et al. and Wang et al. provide global blueprints for transcriptional targets and epigenetic modifications mediated by PML-RARalpha in acute promyelocytic leukemia.
Mikesch
Jan-Henrik
JH
Department of Haematological Medicine, King's College London, UK.
Gronemeyer
Hinrich
H
So
Chi Wai Eric
CW