Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium.
Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for heterogeneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.
Phelan
Catherine M
CM
Department of Epidemiology and Genetics, Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Catherine.Phelan@moffitt.org
Tsai
Ya-Yu
YY
Goode
Ellen L
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Vierkant
Robert A
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Fridley
Brooke L
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Beesley
Jonathan
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Chen
Xiao Qing
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Webb
Penelope M
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Chanock
Stephen
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Cramer
Daniel W
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Moysich
Kirsten
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Edwards
Robert P
RP
Chang-Claude
Jenny
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Garcia-Closas
Montserrat
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Yang
Hannah
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Wang-Gohrke
Shan
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Hein
Rebecca
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Green
Adele C
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Lissowska
Jolanta
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Carney
Michael E
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Lurie
Galina
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Wilkens
Lynne R
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Ness
Roberta B
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Pearce
Celeste Leigh
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Wu
Anna H
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Van Den Berg
David J
DJ
Stram
Daniel O
DO
Terry
Kathryn L
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Whiteman
David C
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Whittemore
Alice S
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DiCioccio
Richard A
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McGuire
Valerie
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Doherty
Jennifer A
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Rossing
Mary Anne
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Anton-Culver
Hoda
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Ziogas
Argyrios
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Hogdall
Claus
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Hogdall
Estrid
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Krüger Kjaer
Susanne
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Blaakaer
Jan
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Quaye
Lydia
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Ramus
Susan J
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Jacobs
Ian
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Song
Honglin
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Pharoah
Paul D P
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Iversen
Edwin S
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Marks
Jeffrey R
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Pike
Malcolm C
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Gayther
Simon A
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Cunningham
Julie M
JM
Goodman
Marc T
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Schildkraut
Joellen M
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Chenevix-Trench
Georgia
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Berchuck
Andrew
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Sellers
Thomas A
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D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D017350:N-Acetylgalactosaminyltransferases / Q000235:genetics*; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044465:White People; D000097763:Polypeptide N-acetylgalactosaminyltransferase
D017350:N-Acetylgalactosaminyltransferases; D000097763:Polypeptide N-acetylgalactosaminyltransferase