Etanercept-induced anti-Jo-1-antibody-positive polymyositis in a patient with rheumatoid arthritis: a case report and review of the literature.
Antitumor necrosis factor (TNF) therapy has been associated with adverse immunologic events including systemic lupus erythematosus. However, the development of polymyositis (PM)/dermatomyositis (DM) associated with anti-TNF therapy is extremely rare. We experienced a case of a 48-year-old female with rheumatoid arthritis (RA) who had anti-Jo-1 antibodies and interstitial lung disease but no previous history of PM/DM and who developed PM soon after the initiation of etanercept (ETN) therapy for RA. The patient recovered upon withdrawal from ETN and corticosteroid (CS) therapies. Only four reports of PM/DM associated with anti-TNF therapy for RA could be found in the literature. The patients described in three of the four reports were positive for anti-Jo-1 antibodies before the initiation of anti-TNF therapy, and in all the cases, recovery occurred after the cessation of anti-TNF-agent administration and CS therapy. These results suggest a relationship between the onset of PM/DM with anti-Jo-1 antibody and anti-TNF therapy for RA.
Department of Rheumatology and Clinical Immunology, Kyoto University Hospital, Kyoto City, Kyoto, Japan.
Yuki
Y
Ishikawa
Naoichiro
N
Yukawa
Koichiro
K
Ohmura
Yuji
Y
Hosono
Yoshitaka
Y
Imura
Daisuke
D
Kawabata
Takaki
T
Nojima
Takao
T
Fujii
Takashi
T
Usui
Tsuneyo
T
Mimori
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000974:Antibodies, Antinuclear / Q000737:chemistry / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy*; D003882:Dermatomyositis / Q000276:immunology; D000068800:Etanercept; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000009:adverse effects*; D007249:Inflammation; D008875:Middle Aged; D017285:Polymyositis / Q000188:drug therapy* / Q000276:immunology*; D018124:Receptors, Tumor Necrosis Factor
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000974:Antibodies, Antinuclear; D007074:Immunoglobulin G; C046750:Jo-1 antibody; D018124:Receptors, Tumor Necrosis Factor; D000068800:Etanercept