Expression pattern of immunoproteasome subunits in human thymus.
The expression pattern of immunoproteasomes in human thymus has not been analyzed but may have important consequences during thymic selection. Here we examined the expression patterns of immunoproteasome subunits in fetal and adult thymic tissues by immunohistochemistry and found that all three subunits are expressed in both cortical and medullary stromal cells. These data suggest that thymic selection in human can be affected by peptide repertoires generated by immunoproteasomes.
Department of Pathology, Hallym University College of Medicine, Chuncheon 200-702, Korea.
Kwon Ik
KI
Oh
Jae Nam
JN
Seo