High-risk HPV genotyping in the follow-up of women treated conservatively for microinvasive cervical cancer.
OBJECTIVE
Conservative management of women with microinvasive cervical cancer (International Federation of Gynecologists and Obstetricians stage IA) has led to prolonged and intensive cytological follow-up. We conducted a retrospective study to assess human papillomavirus status and genotypes at diagnosis and to find out whether there is an association between the persistence of high-risk human papillomavirus during follow-up and the detection of recurrent disease.


METHODS
Paraffin-embedded cervical biopsies in the pathology archives were identified from women with an initial large loop excision of the transformation zone or cone specimen diagnostic of microinvasive disease since 1991.


RESULTS
We identified 45 women with a diagnosis of microinvasive cervical cancer. Human papillomavirus was detected in 87% of the initial diagnostic specimens. Human papillomavirus testing showed a negative predictive value of 100% for recurrent disease with a sensitivity of 100%.


CONCLUSIONS
Human papillomavirus testing has an important role in the follow-up of women treated conservatively for stage IA cervical cancer.
Cairns
Mary
M
Department of Gynaecological Oncology, Aberdeen Royal Infirmary, Scotland AB25 2ZA, UK. marycairns@nhs.net
Cuschieri
Kate S
KS
Cubie
Heather A
HA
Cruickshank
Margaret E
ME
D000328:Adult; D052685:Alphapapillomavirus / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology / Q000601:surgery* / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D013509:Gynecologic Surgical Procedures / Q000379:methods; D052162:Human papillomavirus 16 / Q000235:genetics / Q000302:isolation & purification; D052161:Human papillomavirus 18 / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007247:Infertility, Female / Q000517:prevention & control; D008875:Middle Aged; D019060:Minimally Invasive Surgical Procedures / Q000379:methods*; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000821:virology; D030361:Papillomavirus Infections / Q000150:complications / Q000235:genetics / Q000821:virology*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000473:pathology / Q000601:surgery* / Q000821:virology*; D055815:Young Adult
D004279:DNA, Viral