New insights on fetal ductal constriction: role of maternal ingestion of polyphenol-rich foods.
Fetal ductus arteriosus constriction is a clinical disorder that occurs as a result of inhibition of the prostaglandin synthesis pathway, and has long been associated to maternal intake of nonsteroidal antiinflammatory drugs in late pregnancy. As a consequence of an increased right ventricular pressure, with tricuspid regurgitation and heart failure, there is a risk for the development of neonatal pulmonary artery hypertension. This article reviews the basic knowledge of the mechanisms involved in this important disorder. Clinical and experimental evidence that maternal consumption of polyphenol-rich substances, such as herbal teas, orange and grape juice, chocolate, and others, may interfere with fetal ductus arteriosus dynamics are discussed. Preventive measures to avoid fetal ductal constriction in the third trimester of pregnancy are discussed, including the possible need to change maternal dietary orientation, aiming to limit ingestion of foods with high concentrations of polyphenol-rich substances.
Fetal Cardiology Unit, Institute of Cardiology, Av. Princesa Isabel 395, Porto Alegre 90620-001, Brazil. zielinsky@cardiol.br
Paulo
P
Zielinsky
Antonio Luiz
AL
Piccoli
João Luiz Langer
JL
Manica
Luiz Henrique Soares
LH
Nicoloso
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D000975:Antioxidants / Q000009:adverse effects; D003251:Constriction, Pathologic / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology; D004032:Diet / Q000009:adverse effects*; D004373:Ductus Arteriosus / Q000187:drug effects* / Q000196:embryology / Q000473:pathology; D004452:Echocardiography; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology / Q000517:prevention & control; D005419:Flavonoids / Q000009:adverse effects*; D005504:Food Analysis; D006801:Humans; D010636:Phenols / Q000009:adverse effects*; D059808:Polyphenols; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D039401:Prenatal Nutritional Physiological Phenomena; D016216:Ultrasonography, Prenatal; D018497:Ventricular Dysfunction, Right / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols