Cerebrospinal fluid levels of BAFF and APRIL in untreated multiple sclerosis.
OBJECTIVE
To examine in vivo levels of BAFF (B-cell activating factor of the tumor necrosis factor family) and APRIL (a proliferation-inducing ligand) in both the cerebrospinal fluid (CSF) and serum of 30 naïve MS patients and 79 subjects affected by acute or chronic inflammatory or non-inflammatory neurological diseases.


METHODS
Case-control study.


RESULTS
No difference among groups was evidenced in serum BAFF or APRIL levels. By contrast, CSF levels of BAFF in MS (mean 144.3 pg/ml+/-141.2), although not significantly different from those observed in NIND (164.2 pg/ml+/-92.0), acute peripheral OIND (243.1 pg/ml+/-139.0) or chronic OIND (240.2 pg/ml+/-122.5), were significantly higher in acute central OIND patients (1274.0 pg/ml+/-803.8; p<0.001 vs. all groups). Similarly, CSF APRIL levels in MS (1541.0 pg/ml+/-1071.0), NIND (2629.0 pg/ml+/-1669.0), acute peripheral OIND (2834.0 pg/ml+/-1118.) or chronic OIND (2764.0 pg/ml+/-659.7) were not significantly different, while they were significantly higher in acute central OIND (6218.0 pg/ml+/-3790.0; p<0.001 vs. MS and NIND; and p<0.05 vs. acute peripheral OIND).


CONCLUSIONS
Our results strongly suggest that further investigation is warranted to elucidate the role of BAFF and APRIL in MS and that serum levels of BAFF and APRIL do not reflect CSF levels.
Department of Neuroscience and Biomedical Technologies, University of Milano-Bicocca, Via Cadore 48, 20052, Monza (MI), Italy. fabrizio.piazza@unimib.it
F
F
Piazza
J C
JC
DiFrancesco
M L
ML
Fusco
D
D
Corti
L
L
Pirovano
B
B
Frigeni
L
L
Mattavelli
S
S
Andreoni
M
M
Frigo
C
C
Ferrarese
G
G
Tredici
G
G
Cavaletti
D000328:Adult; D000368:Aged; D053264:B-Cell Activating Factor / Q000032:analysis / Q000097:blood / Q000134:cerebrospinal fluid*; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis / Q000097:blood / Q000134:cerebrospinal fluid; D016022:Case-Control Studies; D002490:Central Nervous System / Q000276:immunology* / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D006801:Humans; D056724:Immunity, Humoral / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000276:immunology* / Q000503:physiopathology; D011237:Predictive Value of Tests; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000032:analysis / Q000097:blood / Q000134:cerebrospinal fluid*; D015854:Up-Regulation / Q000276:immunology
D053264:B-Cell Activating Factor; D015415:Biomarkers; C505719:TNFSF13B protein, human; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13