Treating obesity? It's in the bag!
BRS-3 is an orphan G protein coupled receptor highly expressed in the brain. Pharmacological studies in this issue (Guan et al., 2010) further support a role for this receptor in energy homeostasis and show that the BRS-3 agonist Bag-1 effectively causes weight loss by decreasing food intake and increasing metabolic rate.
Coll
Anthony P
AP
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. apc36@cam.ac.uk