Prompt and successful toxin-targeting treatment of three patients with necrotizing pneumonia due to Staphylococcus aureus strains carrying the Panton-Valentine leukocidin genes.
Three patients with extensive necrotizing pneumonia due to Panton-Valentine leukocidin-positive Staphylococcus aureus strains and with aggravating factors (leukopenia count of less than 3x10(9)/liter in all three cases and hemoptysis in two cases) were successfully treated with toxin-suppressing agents introduced rapidly after hospital admission.
Université de Lyon, INSERM U851, Faculté de Médecine Lyon Est, 7 Rue Guillaume Paradin, 69372 Lyon Cedex 08, France.
Nicolas
N
Rouzic
Frédéric
F
Janvier
Nicolas
N
Libert
Etienne
E
Javouhey
Gerard
G
Lina
Jacques-Yves
JY
Nizou
Pierre
P
Pasquier
Didier
D
Stamm
Louis
L
Brinquin
Christophe
C
Pelletier
François
F
Vandenesch
Daniel
D
Floret
Jerome
J
Etienne
Yves
Y
Gillet
D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D000992:Antitoxins / Q000627:therapeutic use*; D001427:Bacterial Toxins / Q000037:antagonists & inhibitors*; D005098:Exotoxins / Q000037:antagonists & inhibitors*; D006469:Hemoptysis / Q000382:microbiology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007223:Infant; D007956:Leukocidins / Q000037:antagonists & inhibitors*; D007970:Leukopenia / Q000276:immunology; D008297:Male; D008826:Microbial Sensitivity Tests; D009336:Necrosis / Q000150:complications / Q000382:microbiology / Q000628:therapy*; D011023:Pneumonia, Staphylococcal / Q000150:complications / Q000382:microbiology / Q000628:therapy*; D013902:Radiography, Thoracic; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification; D014054:Tomography; D016896:Treatment Outcome; D037521:Virulence Factors / Q000037:antagonists & inhibitors*
D000900:Anti-Bacterial Agents; D000992:Antitoxins; D001427:Bacterial Toxins; D005098:Exotoxins; D016756:Immunoglobulins, Intravenous; D007956:Leukocidins; C078284:Panton-Valentine leukocidin; D037521:Virulence Factors