New insights into T cell biology and T cell-directed therapy for autoimmunity, inflammation, and immunosuppression.
T cell-directed therapies have become mainstays in the management of various autoimmune diseases and organ transplantation. The understanding of T cell biology has expanded greatly since the development of most agents currently in use. Here we discuss important recent discoveries pertaining to T helper cell differentiation, lineage commitment, and function. Within this context, we examine existing T cell-directed therapies, including new agents being evaluated in clinical and preclinical studies. We also use recent findings to speculate on novel targets.
Steward-Tharp
Scott M
SM
Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. stewardtharpsm@mail.nih.gov
Song
Yun-jeong
YJ
Siegel
Richard M
RM
O'Shea
John J
JJ
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D015551:Autoimmunity / Q000276:immunology; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D056747:Immunomodulation / Q000502:physiology*; D007165:Immunosuppression Therapy / Q000379:methods*; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000627:therapeutic use; D007249:Inflammation / Q000276:immunology / Q000628:therapy*; D008954:Models, Biological; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000502:physiology*
D007166:Immunosuppressive Agents