Cinacalcet in the treatment of intractable hypercalcemia following two neck exploration surgeries for primary hyperparathyroidism.
Primary hyperparathyroidism is commonly due to a single, sporadic parathyroid adenoma, and surgery is considered the treatment of choice based on guidelines established by the National Institutes of Health consensus panel. While there is no established medical therapy for this condition, pharmacotherapy with agents such as cinacalcet could be a preferred alternative in a subset of patients with persistent hypercalcemia after one or more surgical interventions.
Padmanabhan
Hema
H
Endocrine Section, Department of Medicine, Veterans Affairs Medical Center, Salem, VA 24153, USA. ramayana48@hotmail.com
D000369:Aged, 80 and over; D040761:Biomimetic Materials / Q000627:therapeutic use; D000069449:Cinacalcet; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy* / Q000209:etiology; D049950:Hyperparathyroidism, Primary / Q000150:complications* / Q000601:surgery; D008297:Male; D009281:Naphthalenes / Q000627:therapeutic use*; D010282:Parathyroid Neoplasms / Q000150:complications* / Q000601:surgery; D044169:Receptors, Calcium-Sensing / Q000819:agonists*
D009281:Naphthalenes; D044169:Receptors, Calcium-Sensing; D000069449:Cinacalcet