The G501C polymorphism of the oxidized low-density lipoprotein-receptor 1 gene is associated with acute coronary syndrome in the Han Chinese population.
Oxidized low-density lipoprotein-receptor 1 (OLR-1) might be involved in the risk of atherosclerosis and its complications. Several studies have been carried out to explore the role of OLR-1 gene polymorphisms in the risk of coronary artery disease. Our study investigated whether the G501C and the 3'UTR C188T polymorphisms of the OLR-1 gene were genetic risk factors of acute coronary syndrome (ACS) in the Han Chinese population. Significant differences were found in genotype frequencies of the OLR-1 G501C polymorphism between 198 ACS patients and 204 control individuals. The CC genotype frequency in the ACS group was significantly higher than that in the control group (5.6% and 1.5% in ACS patients and control subjects, respectively), and the p-value and odds ratio were 0.028 and 3.911, respectively. Using the CC genotype as a reference, we have shown a significant association between carriers of the G allele (GG + GC genotypes) and a decreased risk of ACS (p = 0.026, odds ratio = 0.254, 95% confidence interval = 0.070-0.924). The OLR-1 G501C polymorphism might be associated with ACS in the Han Chinese population.
Department of Immunology, West China School of Basic Science and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu, P.R. China.
Yanyun
Y
Wang
Li
L
Rao
Bin
B
Zhou
Yucheng
Y
Chen
Ying
Y
Peng
Yaping
Y
Song
Lin
L
Zhang
D054058:Acute Coronary Syndrome / Q000150:complications / Q000235:genetics*; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D023921:Coronary Stenosis / Q000150:complications; D048909:Diabetes Complications; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051127:Scavenger Receptors, Class E / Q000235:genetics*; D012907:Smoking / Q000453:epidemiology
C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E