Defining the antigen determinant for T-cell-mediated contact dermatitis using p-phenylenediamine: a gateway to chemical immunology.
By binding to host proteins to form haptens, low-molecular-weight compounds such as p-phenylenediamine (PPD) can become contact sensitizers. In this issue, Jenkinson et al. demonstrate that it is possible to use chemically characterized hapten-protein complexes to analyze T-cell responses in cells from allergic individuals. This approach may help in the development of in vitro tests for diagnosing contact dermatitis.
Elliott
Graham
G
Derphartox, Leiden, The Netherlands.
Das
Pranab Kumar
PK
D000941:Antigens / Q000276:immunology* / Q000378:metabolism; D004396:Coloring Agents; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000276:immunology*; D006241:Haptens / Q000276:immunology; D006801:Humans; D007509:Irritants / Q000276:immunology / Q000378:metabolism; D010655:Phenylenediamines / Q000276:immunology* / Q000378:metabolism; D011485:Protein Binding / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D000941:Antigens; D004396:Coloring Agents; D006241:Haptens; D007509:Irritants; D010655:Phenylenediamines; C029728:4-phenylenediamine