Anti-inflammatory and antioxidant effects of Jeevaneeya Rasayana: an ayurvedic polyherbal formulation on acute and chronic models of inflammation.
The present study was aimed to establish the efficacy of Jeevaneeya Rasayana (JR), an ayurvedic polyherbal formulation, in adjuvant-induced arthritic (AIA) rat model with reference to mediators of inflammation. The methanolic (MJR), ethanolic (EJR), and water extracts (WJR) of JR were prepared and their anti-inflammatory activity in carrageenan-induced acute model was evaluated. MJR at a dose of 25 mg/kg showed significantly higher anti-inflammatory effect than EJR, WJR, and standard drug diclofenac. MJR also significantly decreased the paw edema in AIA rats. Activities of cyclooxygenase, 5-lipoxygenase, and myeloperoxidase were decreased significantly on treatment with MJR. Supplementation with MJR increases the activities of antioxidant enzymes and the level of glutathione content. The increment in the concentration of C-reactive protein, thiobarbituric acid reactive substance, and ceruloplasmin observed in arthritic rats were found to be significantly restored in MJR treated rats. Thus, the results demonstrated the potential beneficiary effect of methanolic extract of Jeevaneeya Rasayana on acute and chronic models of inflammation.
Department of Biochemistry, University of Kerala, Thiruvananthapuram, India.
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Shyni
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Ratheesh
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Sindhu
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Helen
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D001168:Arthritis / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D002351:Carrageenan / Q000494:pharmacology; D002358:Cartilage, Articular / Q000187:drug effects / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D045424:Complex Mixtures / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use / Q000633:toxicity; D004008:Diclofenac / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D005528:Foot / Q000473:pathology; D005620:Freund's Adjuvant / Q000494:pharmacology; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000378:metabolism; D006614:Hindlimb / Q000378:metabolism / Q000473:pathology; D007213:Indomethacin / Q000627:therapeutic use; D007249:Inflammation / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control; D007928:Lethal Dose 50; D008297:Male; D008515:Medicine, Ayurvedic; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D009195:Peroxidase / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014815:Vitamins / Q000097:blood
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D045424:Complex Mixtures; C556341:Jeevaneeya Rasayana; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D014815:Vitamins; D004008:Diclofenac; D002351:Carrageenan; D002097:C-Reactive Protein; D005620:Freund's Adjuvant; D002374:Catalase; D009195:Peroxidase; D005979:Glutathione Peroxidase; D001094:Arachidonate 5-Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D005978:Glutathione; D007213:Indomethacin