Immunomodulatory activity of type-4 resistant starch in the mesenteric lymph nodes of rats.
We evaluated the immunomodulatory activity of type-4 resistant starch (RS) in mesenteric lymph nodes (MLNs) using a rat model. Sixteen male Sprague-Dawley rats were fed either a cellulose diet or an RS diet (RSD) for 4 weeks. Serum immunoglobulin A levels, as well as the CD4(+) T cell population and the ratio of CD4(+)/CD8(+) T cells in the MLNs of rats, were significantly elevated by replacing cellulose with RS in the diet. The survival rate of concanavalin A (Con A)-stimulated MLN lymphocytes and interleukin-4 secretion from the Con A-stimulated MLN lymphocytes were significantly increased in rats fed RSD. These results indicate that type-4 RS might ameliorate allergic inflammation in the MLNs of rats through an increased CD4(+) T cell population and enhanced differentiation of MLN lymphocytes into type-2 T cells.
Song
Youngju
Y
Laboratory of Sports Nutrition, Sunmoon University, Chungnam, Republic of Korea.
Bae
Chunho
C
Woo
Dongho
D
Kim
Yunjung
Y
Park
Taesun
T
D000818:Animals; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002482:Cellulose; D003208:Concanavalin A; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D006967:Hypersensitivity / Q000188:drug therapy; D007070:Immunoglobulin A / Q000097:blood*; D007155:Immunologic Factors / Q000494:pharmacology* / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy*; D015847:Interleukin-4 / Q000378:metabolism; D008198:Lymph Nodes / Q000187:drug effects* / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008643:Mesentery; D051381:Rats; D017207:Rats, Sprague-Dawley; D013213:Starch / Q000494:pharmacology* / Q000627:therapeutic use; D018418:Th2 Cells / Q000187:drug effects / Q000378:metabolism
D004040:Dietary Carbohydrates; D007070:Immunoglobulin A; D007155:Immunologic Factors; D003208:Concanavalin A; D015847:Interleukin-4; D002482:Cellulose; D013213:Starch