Mutagenesis: mutating a gene while reading it.
Is it possible to mutate DNA during transcription? A new study shows that UV-damaged DNA is deaminated during transcription, which is a probable mechanism underlying CC tandem mutations found in the p53 gene in skin cancers.
Helleday
Thomas
T
Gray Institute for Radiation Oncology and Biology, University of Oxford, Oxford, OX3 7DQ, UK. helleday@gmt.su.se
D016158:Genes, p53; D006801:Humans; D016296:Mutagenesis; D012878:Skin Neoplasms / Q000235:genetics; D014158:Transcription, Genetic; D014466:Ultraviolet Rays