Chemzymes: a new class of structurally rigid tricyclic amphibian organocatalyst inspired by natural product.
A new class of structurally rigid tricyclic amphibian chiral catalyst was rationally designed based on the hexahydropyrrolo[2,3-b]indole skeleton as a new type of chemzyme. This new type of chemzyme possesses a structurally rigid tricyclic skeleton and a chiral pocket which provides a well-organized chiral environment for asymmetric induction, as well as a hydrophobic pocket to enable organocatalytic reactions to proceed smoothly both in organic solvents and in water.
Xiao
Jian
J
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.
Xu
Feng-Xia
FX
Lu
Yun-Peng
YP
Loh
Teck-Peng
TP
D000663:Amphibians; D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D015195:Drug Design; D004798:Enzymes; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
D001688:Biological Products; D004798:Enzymes; D007211:Indoles; D011758:Pyrroles; C511200:hexahydropyrrolo(2,3-b)indole