How blocking Raf activates the MAPK pathway.
McCormick
Frank
F
University of California San Francisco, San Francisco, CA, USA. mccormic@cc.ucsf.edu
D006801:Humans; D008545:Melanoma / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D047428:Protein Kinase Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D019908:Proto-Oncogene Proteins c-raf / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
D047428:Protein Kinase Inhibitors; D019908:Proto-Oncogene Proteins c-raf; D020928:Mitogen-Activated Protein Kinases