A tumor suppressor SIRTainty.
Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer Cell, Kim et al. show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.
Department of Pediatrics, Robert F Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. p-schumacker@northwestern.edu
Paul T
PT
Schumacker
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D016147:Genes, Tumor Suppressor / Q000502:physiology*; D006801:Humans; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D056566:Sirtuin 3 / Q000378:metabolism*; D013312:Stress, Physiological / Q000502:physiology*
D017382:Reactive Oxygen Species; C466093:SIRT3 protein, human; D056566:Sirtuin 3