Interleukin-2 tickles T cell memory.
The differentiation of peripheral T lymphocytes depends on interactions between intrinsic and extrinsic factors. In this issue of Immunity, Pipkin et al. (2010) and Kalia et al. (2010) link differential interleukin-2 signaling and inflammation with the transcriptional events leading to the development of effector and memory cells.
Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3052, Australia. belz@wehi.edu.au
Gabrielle T
GT
Belz
Frédérick
F
Masson
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D007376:Interleukin-2 / Q000276:immunology*
D007376:Interleukin-2