The pharmacodynamic effects of rocuronium during general anesthesia in patients with type 2 diabetes mellitus.
OBJECTIVE
The aim of this prospective study was to investigate whether the neuromuscular response to rocuronium is affected by the presence of type 2 diabetes mellitus.


METHODS
Neuromuscular functions were measured after the administration of 0.6 mg/kg rocuronium with train-of-four stimulations in patients with type 2 diabetes mellitus (DM, N=14) and without diabetes mellitus (control, N=14) during isoflurane based general anesthesia. The onset time, clinical duration and recovery index of rocuronium were compared in the two groups.


RESULTS
The mean onset time (136 +/- 40 vs 118 +/- 20 s), clinical duration (51 +/- 11 vs 48 +/- 11 min) and recovery index (6.0 +/- 2.5 vs 5.9 +/- 1.4 min) of the neuromuscular block were not significantly different between the DM and control groups, respectively (p>0.05).


CONCLUSIONS
The present study has proven that the rocuronium-induced neuromuscular block was not affected in patients with type 2 diabetes mellitus during isoflurane based general anesthesia.
Alper
I
I
Department of Anesthesiology and Reanimation, Ege University School of Medicine, Izmir, Turkey. i.alper@yahoo.com
Ulukaya
S
S
Makay
O
O
Balcioglu
T
T
D000328:Adult; D000368:Aged; D000732:Androstanols / Q000008:administration & dosage / Q000494:pharmacology*; D000768:Anesthesia, General; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000494:pharmacology*; D011446:Prospective Studies; D000077123:Rocuronium
D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D000077123:Rocuronium