Captopril and S-nitrosocaptopril as potent radiosensitizers: Comparative study and underlying mechanisms.
In an effort to improve the issue of radiotherapy treatments, we tested whether S-nitrosocaptopril, a molecule combining a NO donor and an angiotensin converting enzyme inhibitor (ACE inhibitor), could temporarily improve the hemodynamic status of experimental tumors. We monitored the effect of S-nitrosocaptopril in TLT tumors using non rinvasive magnetic resonance techniques. We identified a time window during which tumor oxygenation was improved, as a result of a combined effect on tumor blood flow and oxygen consumption. Consequently, the administration of S-nitrosocaptopril contributed to the increase in efficacy of radiation therapy, an effect that was not observed with captopril alone.
Jordan
Bénédicte F
BF
Biomedical Magnetic Resonance Unit, Louvain Drug Research Institute, Université Catholique de Louvain, B-1200 Brussels, Belgium.
Peeterbroeck
Julie
J
Karroum
Oussama
O
Diepart
Caroline
C
Magat
Julie
J
Grégoire
Vincent
V
Gallez
Bernard
B
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D002216:Captopril / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000378:metabolism / Q000532:radiotherapy*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009569:Nitric Oxide; D010101:Oxygen Consumption; D011836:Radiation Tolerance / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology
D000806:Angiotensin-Converting Enzyme Inhibitors; D014665:Vasodilator Agents; C060039:S-nitrosocaptopril; D009569:Nitric Oxide; D002216:Captopril