[Effect of XueBiJing injection upon related proinflammatory factors and blood coagulation factors of vascular endothelial cells in severe septic patients].
OBJECTIVE
To evaluate the effect of Xue Bijing injection in related proinflammatory factors and blood coagulation factors of vascular endothelial cell in severe septic patients.


METHODS
Fifty-two patients were randomly divided into Xue Bijing injection treatment group (Group B) and control group (Group A). Both groups were treated with routine integration treatment, and additionally, patients in Group B received Xue Bijing injection 100 ml intravenous once a day for 7 days while those in Group A received an equal quantity of normal saline as placebo. The changes of VCAM-1, ICAM-1, NO, AT-III, TM, TPA, VWF and PAI-1 in blood serum were tested at Day 0, 3, 7. And the mortality was calculated at Day 28.


RESULTS
The 28-day mortality rate was 32.1% (9/28) in Group B while that of Group A was 62.5% (15/24). There was a significant difference between two groups (P < 0.05). The concentrations of blood serum VCAM-1 and ICAM-1 were significantly lower in Group B than Group A. And the concentrations of blood serum NO, AT-III, TM, TPA, VWF and PAI-1 were significantly higher in Group B than Group A.


CONCLUSIONS
Xue Bijing injection improves a patient's condition and reduces 28-day mortality of severe septic patients. The reason may be that it can stabilize vascular endothelial cell to improve serious inflammatory reaction and blood coagulation dysfunction.
Department of Emergency, Beijing Chao-yang Hospital, Capital Medical University, Beijing 100020, China. lcscyyy@sohu.com
Chun-Sheng
CS
Li
Ming
M
Jin
Jun-Yuan
JY
Wu
Cai-Jun
CJ
Wu
D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D042783:Endothelial Cells / Q000378:metabolism; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D018805:Sepsis / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology
D001779:Blood Coagulation Factors; D004365:Drugs, Chinese Herbal; C549376:Xuebijing