Myocardial perfusion imaging with contrast ultrasound.
This report reviews the development and clinical application of myocardial perfusion imaging with myocardial contrast echocardiography (MCE). This includes the development of microbubble formulations that permit the detection of left ventricular contrast from venous injection and the imaging techniques that have been invented to detect the transit of these microbubbles through the microcirculation. The methods used to quantify myocardial perfusion during a continuous infusion of microbubbles are described. A review of the clinical studies that have examined the clinical utility of myocardial perfusion imaging with MCE during rest and stress echocardiography is then presented. The limitations of MCE are also discussed.
University of Nebraska Medical Center, Cardiology,981165 Nebraska Medical Center, Omaha, Nebraska 68198-1165, USA. trporter@unmc.edu.
Thomas R
TR
Porter
Feng
F
Xie
D000818:Animals; D016477:Artifacts; D003287:Contrast Media / Q000008:administration & dosage; D003326:Coronary Circulation; D025401:Echocardiography, Stress; D006331:Heart Diseases / Q000000981:diagnostic imaging* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D045423:Microbubbles; D008833:Microcirculation; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D009206:Myocardium / Q000473:pathology; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D014022:Tissue Survival
D003287:Contrast Media