Synthesis and characterization of a novel iNOS/Akt inhibitor Se,Se'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea (PBISe)--against colon cancer.
Our studies demonstrate that substitution of sulfur with selenium in known iNOS inhibitor increases the compound's potency by several folds in variety of different cancers cell lines tested. Hence, this approach may be used as a strategy to increase the efficacy of the anticancer agents.
Desai
Dhimant
D
Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA. ddesai@psu.edu
Madhunapantula
SubbaRao V
SV
Gowdahalli
Krishnegowda
K
Sharma
Arati
A
Chandagaludoreswamy
Raghavendragowda
R
El-Bayoumy
Karam
K
Robertson
Gavin P
GP
Amin
Shantu
S
D003110:Colonic Neoplasms / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors*; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors*; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use
D004791:Enzyme Inhibitors; D016566:Organoselenium Compounds; C530804:S,S'-1,4-phenylenebis(1,2-ethanediyl)bisisoselenourea; D014508:Urea; D052247:Nitric Oxide Synthase Type II; D051057:Proto-Oncogene Proteins c-akt