Role of Helicobacter pylori infection in gastric cancer pathogenesis: a chance for prevention.
Gastric cancer in the absence of strategies implemented for early detection continues to have a dismal prognosis. There are limited options for a curative therapy once patients present with clinical manifestations of this malignant disease. Helicobacter pylori (H. pylori) infection plays a key role in gastric carcinogenesis, supported by epidemiological, preclinical and clinical studies. The recognition of H. pylori infection as a critical risk factor in the development of gastric cancer opens the chance for new venues in prevention strategies.
Department of Gastroenterology, Hepatology and Infectious Diseases, Otto-von-Guericke-University of Magdeburg, Leipziger, Magdeburg, Germany. peter.malfertheiner@med.ovgu.de
Peter
P
Malfertheiner
Jan
J
Bornschein
Michael
M
Selgrad
D000465:Algorithms; D000818:Animals; D004195:Disease Models, Animal; D004777:Environment; D020022:Genetic Predisposition to Disease; D016481:Helicobacter Infections / Q000188:drug therapy / Q000382:microbiology*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D008403:Mass Screening / Q000379:methods; D011230:Precancerous Conditions / Q000175:diagnosis / Q000382:microbiology; D013274:Stomach Neoplasms / Q000209:etiology / Q000382:microbiology* / Q000517:prevention & control; D037521:Virulence Factors / Q000502:physiology
D037521:Virulence Factors