Age-related changes in the transmission properties of the human lens and their relevance to circadian entrainment.
OBJECTIVE
To characterize age-related changes in the transmission of light through noncataractous human lenses.


METHODS
Department of Ophthalmology, Glostrup Hospital, Glostrup, Denmark.


METHODS
The spectral transmission of white light was measured along the visual axis in the most central part of the lens in vitro in intact human donor lenses over a wide range of ages.


RESULTS
The study evaluated 28 intact human donor lenses of 15 donors aged 18 to 76 years. Increasing age was associated with gradually decreasing transmission at all visible wavelengths, most prominently at shorter wavelengths. Empirical formulas describing the age-related loss of transmission were created for each spectral color. At 480 nm, the absorption peak for melanopsin, transmission decreased by 72% from the age of 10 years to the age of 80 years.


CONCLUSIONS
The age-related decrease in spectral transmission through the human lens could be modeled by a simple algorithm that may be useful in the design of intraocular lenses that mimic the characteristics of the human lens and in studies of color vision, psychophysics, and melanopsin activation.
Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Nordre Ringvej 57, DK-2600 Glostrup, Denmark. linkes01@glo.regionh.dk
Line
L
Kessel
Jesper Holm
JH
Lundeman
Kristina
K
Herbst
Thomas Vestergaard
TV
Andersen
Michael
M
Larsen
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D007908:Lens, Crystalline / Q000502:physiology* / Q000528:radiation effects*; D008027:Light; D008875:Middle Aged; D017440:Photoperiod; D017299:Rod Opsins / Q000378:metabolism; D013057:Spectrum Analysis; D014019:Tissue Donors; D055815:Young Adult; D000099210:Melanopsin
D017299:Rod Opsins; D000099210:Melanopsin