Multiple synchronous tumors in a child with Fanconi anemia.
Fanconi anemia (FA) is an autosomal recessive inherited syndrome characterized by congenital abnormalities, aplastic anemia, and a high likelihood of developing cancer. We describe a child who presented with 2 synchronous solid tumors (Wilms tumor and neuroblastoma), later found to have FA, who developed severe toxicity and died after a first cycle of chemotherapy. Our experience emphasizes that a predisposing genetic condition should be sought in cases of multiple tumors and that managing FA patients with cancer can be particularly difficult.
Compostella
Alessia
A
Hematology/Oncology Division, Department of Pediatrics, University Hospital of Padova, 35128 Padova, Italy.
Toffolutti
Tiziana
T
Soloni
Pietro
P
Dall'Igna
Patrizia
P
Carli
Modesto
M
Bisogno
Gianni
G
D000310:Adrenal Gland Neoplasms / Q000453:epidemiology / Q000235:genetics; D000741:Anemia, Aplastic / Q000453:epidemiology / Q000235:genetics; D001855:Bone Marrow Diseases / Q000453:epidemiology / Q000235:genetics; D015897:Comorbidity; D019468:Disease Management; D005199:Fanconi Anemia / Q000453:epidemiology* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000453:epidemiology / Q000235:genetics; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology* / Q000235:genetics; D009447:Neuroblastoma / Q000453:epidemiology / Q000235:genetics; D013577:Syndrome; D009396:Wilms Tumor / Q000453:epidemiology / Q000235:genetics