KIT masters mast cells in kids, too.
Adult mastocytosis is usually persistent and caused by c-KIT codon 816-activating mutations. Pediatric mastocytosis is often transient, and the molecular mechanism driving mast cell proliferation in pediatric cases remains unclear. In this issue, Bodemer et al. report novel c-KIT mutations in a large percentage of pediatric cases, identifying both similarities and fundamental differences in the mechanisms causing adult and pediatric mastocytosis.
Department of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan.
Naotomo
N
Kambe
B Jack
BJ
Longley
Yoshiki
Y
Miyachi
Kenji
K
Kabashima
D000328:Adult; D000818:Animals; D002455:Cell Division / Q000502:physiology; D002648:Child; D006801:Humans; D008407:Mast Cells / Q000473:pathology* / Q000502:physiology*; D034701:Mastocytosis, Cutaneous / Q000235:genetics* / Q000473:pathology*; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*
D019009:Proto-Oncogene Proteins c-kit