Impact of LDL-apheresis on inflammation and microcirculation.
Lipid-apheresis (LIPID-A) is highly effective in reduction of pro-atherosclerotic LDL-cholesterol and lipoprotein (a). It has been demonstrated in prospective and retrospective analyses to reduce major cardiovascular events. In addition to improvement of pro-atherosclerotic lipoprotein milieu, LIPID-A exerts pleiotropic effects on inflammation and micro-circulation. Several pro-inflammatory cyto- and chemokines as well as adhesion molecules are cleared by distinct LIPID-A methods. Moreover, a single LIPID-A can induce proliferative activity of circulating endothelial progenitor cells and by this way, enhance vascular repair capacity. Microcirculation is modified by LIPID-A by influencing the balance of vasoconstrictory and -dilatative mediators, plasma viscosity and erythrocyte aggregation resulting in an activation of functional capillary reserve and blood flow.
Department of Nephrology and Rheumatology, Georg-August-University Goettingen, Germany. mkoziolek@med.uni-goettingen.de
Michael J
MJ
Koziolek
Gerhard A
GA
Mueller
D050197:Atherosclerosis / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D015415:Biomarkers / Q000097:blood; D001781:Blood Component Removal; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D007249:Inflammation / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D018836:Inflammation Mediators / Q000097:blood*; D017270:Lipoprotein(a) / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008833:Microcirculation; D016896:Treatment Outcome
D015415:Biomarkers; D018836:Inflammation Mediators; D017270:Lipoprotein(a); D008077:Lipoproteins, LDL