[The parameters of genetic variability and of selection in offsprings of exposed humans].
Mayak workers offsprings parameters of genetic variability including heterozygosity, genetic combinations, quantitative characteristics of genetic class reproduction, genetic identity and intervals, and parameters of selection including relative adaptation of genetic classes and mean adaptation depending on preconceptive doses of parents' exposure were studied. Genetic markers of Mayak workers, their children and grandchildren were defined. Children whose parents had preconceptive doses of more than 200 cGy in comparison with the control group had the heterozygosity reduction by Hp system and tendency to the mean heterozygosity reduction studied genetic system. Also they had modifications in the frequency of combinations of separate genotypes and blood groups, genetic identity reduction and genetic interval increasing, increasing of the mean adaptation and reduction of the mean coefficient of selection by genetic system of Hp. Consequently the children of workers, preconceptively exposed to gamma-radiation in doses over 200 cGy, are susceptive to the gametic selection on system of Hp that realizes at their conception. In grandchildren, whose grandparents had preconceptive doses over 200 cGy, no changes in genotype Hp distribution were detected compared to controls. The absence of changes in genotype Hp distribution in workers' grandchildren is accounted for the absence of increased preconceptive exposure doses of their parents (F1-children), as well as for their marriages to the individuals (in 94.3% of cases), whose parents didn't have high (over 200 cGy) preconceptive exposure doses.
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D000017:ABO Blood-Group System / Q000235:genetics; D002617:Chemical Industry; D002648:Child; D016241:Child of Impaired Parents; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D005796:Genes / Q000528:radiation effects*; D014644:Genetic Variation; D006242:Haptoglobins / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D008297:Male; D018811:Maternal Exposure; D016273:Occupational Exposure; D018812:Paternal Exposure; D010375:Pedigree; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology / Q000235:genetics*; D011832:Radiation Injuries; D018788:Radioactive Hazard Release; D012426:Russia; D012641:Selection, Genetic
D000017:ABO Blood-Group System; D006242:Haptoglobins