Genetic polymorphisms in cytochrome P450s, GSTs, NATs, alcohol consumption and risk of non-Hodgkin lymphoma.
The aim of this study was to investigate whether genetic polymorphisms in cytochrome P450s (CYPs), glutathione S-transferases (GSTs), and N-acetyltransferases (NATs) genes modify the relationship between alcohol consumption and risk of non-Hodgkin's lymphoma (NHL) in a population-based, case-control study including 1,115 Connecticut women. Although we did not find strong evidence that the genetic polymorphisms modify the relationship between alcohol consumption and risk of NHL, we identified significant interactions for multiple GSTs and NATs and alcohol intake among persons with DLBCL. Our results confer support investigation of the gene-environment interaction in a larger study population of DLBCL.
Yonghong
Y
Li
Tongzhang
T
Zheng
Briseis A
BA
Kilfoy
Qing
Q
Lan
Theodore
T
Holford
Xuesong
X
Han
Ping
P
Zhao
Min
M
Dai
Brian
B
Leaderer
Nat
N
Rothman
Yawei
Y
Zhang
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000453:epidemiology* / Q000235:genetics; D000434:Alcoholic Beverages / Q000009:adverse effects / Q000145:classification / Q000706:statistics & numerical data; D001191:Arylamine N-Acetyltransferase / Q000235:genetics*; D001711:Biotransformation / Q000235:genetics; D002273:Carcinogens / Q000493:pharmacokinetics; D016022:Case-Control Studies; D003237:Connecticut / Q000453:epidemiology; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000201:enzymology / Q000453:epidemiology* / Q000235:genetics; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology / Q000235:genetics; D055815:Young Adult
D002273:Carcinogens; D003577:Cytochrome P-450 Enzyme System; D001191:Arylamine N-Acetyltransferase; D005982:Glutathione Transferase