Matrix metalloproteinase-9 polymorphism and risk of pelvic organ prolapse in Taiwanese women.
OBJECTIVE
Matrix metalloproteinase-9 is known to play an important role in the pathophysiology of pelvic organ prolapse. We investigated whether the matrix metalloproteinase-9 gene polymorphisms were associated with pelvic organ prolapse by conducting a case-control association study in 92 women with pelvic organ prolapse and 152 women without pelvic organ prolapse.


METHODS
Genotypes of the matrix metalloproteinase-9 gene polymorphisms (rs3918242, rs17576, and rs2250889) were determined by polymerase chain reaction, followed by restriction fragment length polymorphism analysis.


RESULTS
There was significant difference between women with and without pelvic organ prolapse in the distribution of the matrix metalloproteinase-9 rs17576 genotypes evaluated. Using multivariable logistic regression, menopausal status, matrix metalloproteinase-9 rs17576 genotype AG, and matrix metalloproteinase-9 rs17576 genotype GG were significantly associated with pelvic organ prolapse.


CONCLUSIONS
The present study shows that the polymorphism of matrix metalloproteinase-9 rs17576 may be associated with pelvic organ prolapse.
Department of Obstetrics and Gynecology, China Medical University Hospital, Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan.
Huey-Yi
HY
Chen
Wei-Yong
WY
Lin
Yung-Hsiang
YH
Chen
Wen-Chi
WC
Chen
Fuu-Jen
FJ
Tsai
Chang-Hai
CH
Tsai
D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020780:Matrix Metalloproteinase 9 / Q000235:genetics*; D056887:Pelvic Organ Prolapse / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012306:Risk; D013624:Taiwan
D020780:Matrix Metalloproteinase 9