[Research advance on transferrin receptor in hematological malignant tumor treatment].
Iron is one of the necessary elements for cell growth, proliferation and functional activities. Iron uptake of the vast majority cells, including tumor cells, is primarily mediated by transferrin receptor (TfR). Studies showed that transferrin receptor expressed on tumor cell surface at a high level, thus can be used in the treatment for malignant tumor combined with many kinds of materials. In this article, recent progress of study on transferrin receptor used in treating hematological malignant tumor are reviewed from aspects of transferrin receptor combined with drugs including artemisinin, doxorubicin, gambogic acid and so on, genes, antibodies, polyethylene glycol and nanoparticles.
Department of Hematology, Zhongda Hospital, Southeast University Clinical Medical College, Nanjing 210009, Jiangsu Province, China.
Ran
R
Liu
Shu
S
Chen
Bao-An
BA
Chen
D019337:Hematologic Neoplasms / Q000378:metabolism* / Q000628:therapy*; D006801:Humans; D011990:Receptors, Transferrin / Q000378:metabolism* / Q000627:therapeutic use
D011990:Receptors, Transferrin