[Changes of the concentration of serum ischemia modified albumin and high sensitivity C-reactive protein in type 2 diabetic patients with retinopathy].
OBJECTIVE
To explore the changes of the concentration of serum ischemia modified albumin (IMA) and high sensitivity C-reactive protein (hs-CRP) in type 2 diabetic patients with retinopathy (DR).


METHODS
The concentration of serum IMA and hs-CRP in DR patients were determined by ELISA and rate nephelometry and compared with those in 83 no-DR (NDR) patients and 72 controls. The concentration of serum IMA and hs-CRP in 40 proliferative diabetic retinopathy (PDR) patients were compared with those in 39 no-PDR (NPDR) patients. Data was evaluated using analysis of PPMS version 1.5.Results are expressed as means + or - standard deviation of the mean. Statistical comparisons were performed by student's t-test or one-way analysis of variance followed by Dunnett's multiple comparison test and the means compared each other using q test.


RESULTS
The serum IMA and hs-CRP concentration in DR patients were (46.51 + or - 13.29) microg/L, (4.27 + or - 2.24) mg/L. The serum IMA and hs-CRP concentration in NDR patients were (25.47 + or - 9.33) microg/L, (2.96 + or - 1.84) mg/L. The serum IMA and hs-CRP concentration in controls were (15.36 + or - 4.27) microg/L, (1.86 + or - 0.97) mg/L. The serum IMA and hs-CRP concentration in PDR patients were (54.72 + or - 15.61) microg/L, (6.34 + or - 3.53) mg/L. The serum IMA and hs-CRP concentration in NPDR patients were (38.35 + or - 11.27) microg/L, (3.28 + or - 1.77) mg/L. The serum IMA and hs-CRP concentration were significantly higher in DR patients than those in controls and NDR patients, the serum IMA and hs-CRP concentration in NDR patients were significantly higher than those in controls (F = 197.124, 34.561;q = 5.41-27.34; P < 0.01); the serum IMA and hs-CRP concentration were significantly higher in PDR patients than those in NPDR patients (t = 5.46, 4.89; P < 0.01); there was significant positive correlation between serum IMA concentration and hs-CRP concentration in DR patients (r = 0.617, P < 0.01).


CONCLUSIONS
The serum IMA and hs-CRP concentration were significantly high in DR patients, and were positively associated with the seriousness of DR, which may contribute to the development of DR.
Department of Endocrinology, The Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, China. jiazt@126.com
Zhao-tong
ZT
Jia
Cheng-yu
CY
Liu
Hong
H
Li
D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003930:Diabetic Retinopathy / Q000097:blood*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood; D008875:Middle Aged; D012709:Serum Albumin / Q000378:metabolism*
D012709:Serum Albumin; D002097:C-Reactive Protein