FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients.
Two promoter polymorphisms of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha) gene (FCER1A), -66T>C (rs2251746) and -315C>T (rs2427827), were analysed in Japanese atopic dermatitis subjects. Patients with the -315CT/TT genotype tended to have higher total serum IgE levels, while the proportion of -315CT/TT genotype or the -315T allele was significantly higher in those with highly elevated total serum IgE concentrations.
Atopy (Allergy) Research Center, Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.
Y
Y
Niwa
D P
DP
Potaczek
S
S
Kanada
A
A
Takagi
N
N
Shimokawa
T
T
Ito
K
K
Mitsuishi
Y
Y
Okubo
M
M
Tajima
A
A
Hobo
W
W
Ng
R
R
Tsuboi
S
S
Ikeda
H
H
Ogawa
K
K
Okumura
C
C
Nishiyama
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D003876:Dermatitis, Atopic / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007564:Japan; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D017455:Receptors, IgE / Q000235:genetics*; D055815:Young Adult
C475664:FCER1A protein, human; D017455:Receptors, IgE; D007073:Immunoglobulin E