Metastatic uterine leiomyosarcomas: a single-institution experience.
BACKGROUND
Uterine leiomyosarcoma (LMS) is a rare disease and, when it recurs or metastasizes, can rarely be cured. In a retrospective study, we summarized our experience in treating a large cohort of patients with metastatic uterine LMS.


METHODS
Cases of recurrent or metastatic uterine LMS diagnosed between 2000 and 2008 were analyzed. Survival was determined from the time of initial diagnosis to last follow-up.


RESULTS
Thirty-three patients (median age, 55 years) were identified. Eighteen patients were initially diagnosed with localized disease. Median disease-free interval was 5.25 months, and overall survival (OS) is 43.7 months. Median OS of 15 patients with initially discovered metastatic disease is 31.4 months. Different chemotherapy regimens produced approximately 30% response rates. Twelve patients underwent at least 1 surgical resection of pulmonary or extrapulmonary metastases. In this group, median progression-free survival was 7.9 months (range, 0-33.9 months), median OS was 45.2 months (range, >8.1-78.8 months), 2-year survival rate was 83%, and 4-year survival rate was 25%.


CONCLUSIONS
Very few patients with recurrent or metastatic uterine LMS can be curatively treated. Our experience suggests that modern multimodal therapy or combining chemotherapy with aggressive surgery in selected patients may be significant in prolonging survival of women with this fatal disease.
Bernstein-Molho
Rinat
R
Division of Oncology, Tel-Aviv Sourasky Medical Center, Tel-Aviv, Israel. rinat.bern@gmail.com
Grisaro
Dan
D
Soyfer
Vjacheslav
V
Safra
Tamar
T
Merimsky
Ofer
O
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007557:Israel / Q000453:epidemiology; D007890:Leiomyosarcoma / Q000401:mortality* / Q000556:secondary / Q000628:therapy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000628:therapy; D012189:Retrospective Studies; D014594:Uterine Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy; D014599:Uterus / Q000473:pathology