Processing and presentation of antigens derived from intracellular protozoan parasites.
Control of parasitic protozoan infections requires the generation of efficient innate and adaptive immune responses, and in most cases both CD8 and CD4 T cells are necessary for host survival. Since intracellular protozoa remodel the vacuolar compartments in which they reside, it is not obvious how their antigens enter the MHC class I and class II pathways. Studies using genetically engineered parasites have shown that host cell targeting, intracellular compartmentalization, subcellular localization of antigen within the parasite, and mechanism of invasion are important factors determining the presentation pathway utilized. The recent identification of endogenous parasite-derived CD8 T cell epitopes have helped confirm these concepts as well as provided new information on the processing pathways and the impact of parasite-stage specific antigen expression on the repertoire of responding T cells stimulated by infection. Elucidating the mechanisms governing antigen processing and presentation of intracellular protozoa may provide important insights needed for the rational design of effective vaccines.
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. rgoldszmid@mail.nih.gov
Romina S
RS
Goldszmid
Alan
A
Sher
D000818:Animals; D017951:Antigen Presentation; D000953:Antigens, Protozoan / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000276:immunology; D006790:Host-Parasite Interactions; D006801:Humans; D042541:Intracellular Space / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000953:Antigens, Protozoan; D006649:Histocompatibility Antigens