[PPARgamma-gene therapy].
In recent years, there has been increasing evidence that peroxisome proliferators-activated receptor gamma (PPARgamma) plays crucial roles in various pathophysiological processes, some of which are associated with a decrease in the expression of PPARgamma. Our previous study demonstrated that gene delivery of PPARgamma could be used to restore and/or enhance endogenous anti-inflammatory processes that are normally operative in mammalian tissues such as colon. In this review, we describe the outline of recent progress in the development of PPARgamma-gene therapy and PPARgamma molecular pathways, along with the results obtained in our previous experiments and those reported by others.
Department of Biochemistry and Molecular Biology, Graduate School of Pharmaceutical Sciences, Osaka University.
Kazufumi
K
Katayama
Atsushi
A
Nakajima
D000818:Animals; D015316:Genetic Therapy / Q000379:methods*; D007249:Inflammation / Q000628:therapy; D015212:Inflammatory Bowel Diseases / Q000628:therapy; D047495:PPAR gamma / Q000235:genetics*
D047495:PPAR gamma