The G501C polymorphism of the oxidized low-density lipoprotein-receptor 1 gene is associated with acute coronary syndrome in the Han Chinese population.
Oxidized low-density lipoprotein-receptor 1 (OLR-1) might be involved in the risk of atherosclerosis and its complications. Several studies have been carried out to explore the role of OLR-1 gene polymorphisms in the risk of coronary artery disease. Our study investigated whether the G501C and the 3'UTR C188T polymorphisms of the OLR-1 gene were genetic risk factors of acute coronary syndrome (ACS) in the Han Chinese population. Significant differences were found in genotype frequencies of the OLR-1 G501C polymorphism between 198 ACS patients and 204 control individuals. The CC genotype frequency in the ACS group was significantly higher than that in the control group (5.6% and 1.5% in ACS patients and control subjects, respectively), and the p-value and odds ratio were 0.028 and 3.911, respectively. Using the CC genotype as a reference, we have shown a significant association between carriers of the G allele (GG + GC genotypes) and a decreased risk of ACS (p = 0.026, odds ratio = 0.254, 95% confidence interval = 0.070-0.924). The OLR-1 G501C polymorphism might be associated with ACS in the Han Chinese population.
Wang
Yanyun
Y
Department of Immunology, West China School of Basic Science and Forensic Medicine, Sichuan University (West China University of Medical Sciences), Chengdu, P.R. China.
Rao
Li
L
Zhou
Bin
B
Chen
Yucheng
Y
Peng
Ying
Y
Song
Yaping
Y
Zhang
Lin
L
D054058:Acute Coronary Syndrome / Q000150:complications / Q000235:genetics*; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D023921:Coronary Stenosis / Q000150:complications; D048909:Diabetes Complications; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051127:Scavenger Receptors, Class E / Q000235:genetics*; D012907:Smoking / Q000453:epidemiology
C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E