Partially erupted third molars as a potential source of infection in patients receiving peripheral stem cell transplantation for malignant diseases: a retrospective study.
Forty-four patients with malignant diseases for which they received peripheral stem cell transplant therapy (PSCT) were retrospectively studied regarding local and systemic infection originating from around partially erupted third molars (PEMs). Twenty-two patients had one or more PEMs, while 22 patients had none. Data were retrieved from medical and dental records. Systemic and local signs of infection and treatment were assessed. We recorded the number of transplanted CD34(+) blood stem cells, days with white blood cell counts < 0.5 x 10(9) l(-1), days until engraftment, maximum level of C-reactive protein (CRP), days with fever, positive blood cultures, days taking antibiotics, days drinking < 0.5 l, days of total parenteral nutrition, days receiving intravenously administered analgesics, and number of admission days. No statistically significant difference was detected between patients with PEMs and those without PEMs regarding any of the studied parameters. Of patients with PEMs, 36% (8 of 22) developed local infections around PEMs during the PSCT period. The study indicates that PEMs pose no significant risk of causing systemic infection in patients receiving PSCT for malignant diseases but increase the risk of developing a local infection, justifying close supervision and early treatment in cases of local infection during PSCT treatment.
Clinic of Oral Medicine, Public Dental Service, Västra Götalandsregionen, Medicinaregatan, Göteborg, Sweden. david.ohman@vgregion.se
David
D
Ohman
Yvonne
Y
Björk
John
J
Bratel
Camilla
C
Kristiansson
Peter
P
Johansson
Jan-Erik
JE
Johansson
Mats
M
Brune
Bengt
B
Hasséus
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D005260:Female; D005491:Focal Infection, Dental / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D008964:Molar, Third / Q000473:pathology*; D036102:Peripheral Blood Stem Cell Transplantation; D012189:Retrospective Studies; D012306:Risk; D018709:Statistics, Nonparametric; D014097:Tooth, Unerupted / Q000150:complications* / Q000473:pathology; D055815:Young Adult
D000900:Anti-Bacterial Agents; D002097:C-Reactive Protein