Heat treatment of electrospun silicate fiber substrates enhances cellular adhesion and proliferation.
Synthetic scaffolds support cell attachment in vitro. We prepared ultra-fine silicate fibers using the sol-gel process and electrospinning, heated the fibers to 500 degrees C and investigated their effects on the behavior of human hepatocellular carcinoma (HepG2) cells. Alterations in surface composition following heat treatment improved cell adhesion and influenced cell migration.
Yamaguchi
Tetsu
T
Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center, 1465-5 Aikawa, Kurume, Fukuoka 839-0861, Japan. tetsu@fitc.pref.fukuoka.jp
Sakai
Shinji
S
Watanabe
Rie
R
Tarao
Takashi
T
Kawakami
Koei
K
D002448:Cell Adhesion / Q000502:physiology*; D049109:Cell Proliferation; D004563:Electrochemistry / Q000379:methods*; D056945:Hep G2 Cells; D006358:Hot Temperature; D006801:Humans; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D012399:Rotation; D017640:Silicates / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
D017640:Silicates