The neurobiology of repetitive behavior: of mice….
Repetitive and stereotyped behavior is a prominent element of both animal and human behavior. Similar behavior is seen across species, in diverse neuropsychiatric disorders and in key phases of typical development. This raises the question whether these similar classes of behavior are caused by similar neurobiological mechanisms or whether they are neurobiologically unique? In this paper we discuss fundamental animal research and translational models. Imbalances in corticostriatal function often result in repetitive behavior, where different classes of behavior appear to be supported by similar neural mechanisms. Although the exact nature of these imbalances are not yet fully understood, synthesizing the literature in this area provides a framework for studying the neurobiological systems involved in repetitive behavior.
Department of Child and Adolescent Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands. m.langen@umcutrecht.nl
Marieke
M
Langen
Martien J H
MJ
Kas
Wouter G
WG
Staal
Herman
H
van Engeland
Sarah
S
Durston
D000818:Animals; D001321:Autistic Disorder; D001921:Brain / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D007175:Impulsive Behavior; D051379:Mice; D009434:Neural Pathways / Q000473:pathology; D009446:Neurobiology; D009771:Obsessive-Compulsive Disorder; D013239:Stereotyped Behavior / Q000502:physiology*; D057170:Translational Research, Biomedical