Corifollitropin alfa in a long GnRH agonist protocol: proof of concept trial.
Fifty healthy women, aged 18-39 years with no known risk of ovarian hyperstimulation were treated with 100 or 150 μg corifollitropin alfa (dependent on body weight) in a long GnRH agonist protocol. At these doses, corifollitropin alfa initiated and supported growth of a large cohort of follicles during the first week of ovarian stimulation.
Fatemi
Human M
HM
Center for Reproductive Medicine, Universitair Ziekenhuis Brussel, Brussels, Belgium.
Oberyé
Janine
J
Popovic-Todorovic
Biljana
B
Witjes
Han
H
Mannaerts
Bernadette
B
Devroey
Paul
P
D000293:Adolescent; D000328:Adult; D002452:Cell Count; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D015331:Cohort Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D043373:Follicle Stimulating Hormone, Human / Q000494:pharmacology*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007265:Inhibins / Q000378:metabolism; D054315:Oocyte Retrieval; D009865:Oocytes / Q000166:cytology; D006080:Ovarian Follicle / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010062:Ovulation Induction / Q000379:methods*; D010865:Pilot Projects; D011247:Pregnancy; D018873:Pregnancy Rate; D011994:Recombinant Proteins / Q000494:pharmacology*; D055815:Young Adult
D006063:Chorionic Gonadotropin; D043373:Follicle Stimulating Hormone, Human; D011994:Recombinant Proteins; C437186:follicle stimulating hormone, human, with HCG C-terminal peptide; C422364:inhibin B; D007987:Gonadotropin-Releasing Hormone; D007265:Inhibins; D005640:Follicle Stimulating Hormone