Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii.
A new bisindole alkaloid, bisleuconothine A (1) consisting of an eburnane-aspidosperma type skeleton, was isolated from the bark of Leuconotis griffithii. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and X-ray analysis. Bisleuconothine A (1) showed cell growth inhibitory activity against various human cancer cell lines.
Hirasawa
Yusuke
Y
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Shoji
Tomokazu
T
Arai
Takashi
T
Nugroho
Alfarius E
AE
Deguchi
Jun
J
Hosoya
Takahiro
T
Uchiyama
Nahoko
N
Goda
Yukihiro
Y
Awang
Khalijah
K
Hadi
A Hamid A
AH
Shiro
Motoo
M
Morita
Hiroshi
H
D029062:Apocynaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular
D026121:Indole Alkaloids; C550713:bisleuconothine A