Posterior spinal artery infarct due to patent foramen ovale: a case report.
METHODS
Case report.


OBJECTIVE
To report the first case of posterior spinal artery (PSA) infarct due to patent foramen ovale (PFO).


BACKGROUND
Infarct in the territories of PSA are very rare: till now 38 cases are reported in the literature. Moreover only 1 case of spinal cord infarction was attributed to paradoxical embolism through PFO, but in the anterior spinal artery territory.


METHODS
A 60-year-old woman was hospitalized for sudden numbness of the right leg. Neurologic examination revealed right leg mild paresis and loss of proprioception and dysesthesia at T11. Spine-MRI showed T5-T7 posterolateral cord ischemia. Transesophageal echocardiography disclosed a PFO with severe right-left shunt confirmed by transcranial Doppler.


RESULTS
During the hospitalization she was treated with oral-500 mg ticlopidine, because of a mild allergic reaction to acetylsalicylic acid. No steroids were administrated. Physiotherapy was performed daily. Motor and urinary symptoms disappeared in 20 days. At 1-month clinical follow-up only suspended dysesthesia on the right side was present. At 3 months follow-up spine-MRI showed no signal abnormalities within the spinal cord but the patient still complained of dysesthesia. The therapy was changed to oral 75 mg clopidogrel, cause of leucopoenia. At 1-year follow-up dysesthesia was still present, but less complaining and no recurrence and adverse effect due to clopidogrel therapy were reported.


CONCLUSIONS
This report describe a case of acute nontraumatic myelopathy. At 4 days after onset, PSA infarct was diagnosed on the basis of neurologic findings and MR images. After extensive diagnostic work-up, we were able to identify only PFO, so it was the first case of PSA due to probable paradoxical embolism. The patient was treated with antiplatelet therapy with good recovery and no recurrence at 1-year follow-up.
Petruzzellis
Marco
M
U O Neurologia Universitaria e Stroke Unit Francomichele Puca Dipartimento di Scienze Neurologiche e Psichiatriche Università di, Bari, Italy. mpetruz@hotmail.com
Fraddosio
Angela
A
Giorelli
Maurizio
M
Prontera
Mariapia
M
Tinelli
Angelica
A
Lucivero
Vincenzo
V
Federico
Francesco
F
D018572:Disease-Free Survival; D005260:Female; D054092:Foramen Ovale, Patent / Q000150:complications*; D006801:Humans; D007238:Infarction / Q000209:etiology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D026741:Physical Therapy Modalities; D013116:Spinal Cord / Q000098:blood supply*; D013988:Ticlopidine / Q000627:therapeutic use; D016896:Treatment Outcome
D013988:Ticlopidine