[Plasma membrane focal defects in structurally normal cells].
The technique of perfusion fixation through the rat kidney vasculature was modified to ensure the highest possible level of cell preservation close to that under in vivo conditions. Electron microscopic analysis of the tissue specimens treated in such a way revealed local defects of the plasma membrane in a number of cells than that otherwise looked normal. These findings together with the evidence for reparability of such defects and some data on the purely artificial nature of certain alterations should be taken into consideration in order to avoid misinterpretations while diagnosing the biopsy specimens.
A I
AI
Nevorotin
S E
SE
Khokhlov
E A
EA
Borisova
V G
VG
Sipovskiĭ
S G
SG
Chefu
D000818:Animals; D016477:Artifacts; D002462:Cell Membrane / Q000648:ultrastructure*; D007668:Kidney / Q000648:ultrastructure*; D010477:Perfusion; D051381:Rats; D016707:Tissue Fixation