Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK.
Obesity is a risk factor for chronic kidney disease (CKD) and nonalcoholic fatty liver disease (NAFLD). Recent studies identify mechanisms common to both diseases linked through an interorgan communication orchestrated by fetuin-A and adiponectin. In liver and kidney, the energy sensor 5'-AMP activated protein kinase (AMPK) is pivotal to directing podocytes and hepatocytes to compensatory and potentially deleterious pathways, leading to inflammatory and profibrotic cascades culminating in end-organ damage. Regulation of these early upstream pathways may provide new therapeutic targets for these increasingly common sequelae of obesity.
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Joachim H
JH
Division of Nephrology and Hypertension, Department of Medicine, University of California-San Diego/Veterans Affairs San Diego Healthcare System, CA 92093-0711, USA.
Sharma
Kumar
K
D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D052242:Adiponectin / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism*; D005234:Fatty Liver / Q000453:epidemiology / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000378:metabolism*; D009765:Obesity / Q000453:epidemiology / Q000378:metabolism*; D012307:Risk Factors; D060749:alpha-2-HS-Glycoprotein
C499918:ADIPOQ protein, human; C556354:AHSG protein, human; D052242:Adiponectin; D001798:Blood Proteins; D060749:alpha-2-HS-Glycoprotein; D055372:AMP-Activated Protein Kinases