[Optimization of use of beta-adrenoblockers in the treatment of chronic heart failure in the outpatient setting].
OBJECTIVE
to evaluate of the effectiveness of switching from beta-adrenoblockers (BAB) non-included into the guidelines for the management of chronic heart failure (CHF) to nebivolol and bisoprolol for outpatients.


METHODS
The study included 67 patients with stable Functional Classes (FC) II and II CHF who received the standard therapy and BAB non-included into the guidelines for the management of CHF. The patients were randomized to the groups taking bisoprolol (n = 35) or nebivolol (n = 32) in doses of 1.25 to 10 mg/day. Before and 6 months after therapy, the investigators assessed the patient's clinical status and quality of life (QL), performed a six-minute walk test and echography, and determined the blood level of the N-terminal fragment of brain natriuretic peptide prohormone (NT-proBNP).


RESULTS
The switching to bisoprolol and nebivolol was followed by a significant clinical improvement, a larger covered distance, and better QL. Left ventricular ejection fraction was increased along with a reduction in mean FC CHF. There were no significant changes in NT-proBNP in the total patient group, but it was significantly decreased in the subgroup of those with the baseline high level of the peptide.


CONCLUSIONS
The switching of patients with stable CHF from therapy with BAB not included into the guidelines for the management of CHF to nebivolol or bisoprolol yields positive results and improves left ventricular systolic function (which is attended by the reduction in NT-proBNP levels) and may be recommended for treatment in the outpatient setting.
Zhubrina
E S
ES
Ovchinnikov
A G
AG
Seredenina
E M
EM
Patrusheva
I F
IF
Blankova
Z N
ZN
Kuz'mina
A E
AE
Kheĭmets
G I
GI
Ageev
F T
FT
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage*; D000368:Aged; D000553:Ambulatory Care; D001578:Benzopyrans / Q000008:administration & dosage*; D017298:Bisoprolol / Q000008:administration & dosage*; D002908:Chronic Disease; D004983:Ethanolamines / Q000008:administration & dosage*; D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006352:Heart Ventricles / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D000068577:Nebivolol; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy*; D016277:Ventricular Function, Left / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D001578:Benzopyrans; D004983:Ethanolamines; D000068577:Nebivolol; D017298:Bisoprolol