Light chain deposition disease as a rare cause of restrictive cardiomyopathy.
We report an unusual case of a 47-year-old Caucasian woman who presented with severe dyspnoea as a manifestation of restrictive cardiomyopathy, found to be due to myocardial deposition of kappa light chains. Non-routine specific immunofluorescence stainings of endomyocardial biopsy specimens were key for the diagnosis of myocardial light chain deposition disease. We discuss non-amyloidotic cardiac immunoglobulin deposition disease in contrast to cardiac amyloidosis.
Department of Cardiology, Heilig Hart Ziekenhuis, Roeselare, Belgium.
Pieter
P
Koopman
Jo
J
Van Dorpe
Bart
B
Maes
Karl
K
Dujardin
D002313:Cardiomyopathy, Restrictive / Q000209:etiology*; D004396:Coloring Agents; D003224:Congo Red; D004417:Dyspnea / Q000209:etiology*; D004699:Endocardium / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000378:metabolism; D007150:Immunohistochemistry; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D010265:Paraproteinemias / Q000150:complications*
D004396:Coloring Agents; D007147:Immunoglobulin Light Chains; D003224:Congo Red