Factor VIIa interaction with endothelial cells and endothelial cell protein C receptor.
Plasma coagulation factor VIIa (FVIIa) initiates the coagulation cascade by binding to its cofactor, tissue factor (TF) on cell surfaces, which eventually leads to fibrin deposition and platelet activation. Recent studies showed that FVIIa also binds to endothelial cell protein C receptor (EPCR), a known cellular receptor for anticoagulant protein C\activated protein C, on the endothelium. The present article reviews our current knowledge of FVIIa interaction with EPCR and discusses the potential significance of this interaction in hemostasis, treatment of bleeding disorders with pharmacological doses of FVIIa and FVIIa clearance.
Pendurthi
Usha R
UR
Center for Biomedical Research, The University of Texas Health Science Center at Tyler, TX 75708, USA. usha.pendurthi@uthct.edu
Rao
L Vijaya Mohan
LV
D001665:Binding Sites; D001779:Blood Coagulation Factors / Q000737:chemistry*; D042783:Endothelial Cells / Q000166:cytology; D004730:Endothelium, Vascular / Q000378:metabolism; D015942:Factor VIIa / Q000737:chemistry*; D005337:Fibrin / Q000737:chemistry; D005786:Gene Expression Regulation; D006467:Hemophilia A / Q000378:metabolism; D006487:Hemostasis; D006801:Humans; D008954:Models, Biological; D011956:Receptors, Cell Surface / Q000737:chemistry*; D013925:Thromboplastin / Q000378:metabolism
D001779:Blood Coagulation Factors; D011956:Receptors, Cell Surface; C091963:activated protein C receptor; D005337:Fibrin; D013925:Thromboplastin; D015942:Factor VIIa