Turning the page on epigenetic bookmarks.
Cells remember established patterns of gene expression through rounds of cell division despite dynamic changes in genomic chromatin structure. Two recent studies in Molecular Cell and Nature Medicine, broadly impacting on epigenetic gene regulation and disease, address how cells remember and suggest that both histone methyltransferases and locus specific DNA binding proteins can mark transcribed genes for reactivation after mitosis.
Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA. dressler@umich.edu
Gregory R
GR
Dressler
D000818:Animals; D001665:Binding Sites / Q000235:genetics; D019175:DNA Methylation / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics; D029721:Drosophila Proteins / Q000235:genetics; D044127:Epigenesis, Genetic / Q000235:genetics*; D005786:Gene Expression Regulation / Q000235:genetics*; D051539:Hepatocyte Nuclear Factor 1-beta / Q000235:genetics; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics; D006801:Humans; D008938:Mitosis / Q000235:genetics*; D015533:Transcriptional Activation / Q000235:genetics*
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D051539:Hepatocyte Nuclear Factor 1-beta; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase; C524066:PRC2 protein, Drosophila