Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder.
Frontal systems dysfunction and abandonment fears represent central features of borderline personality disorder (BPD). BPD subjects (n=10) and matched non-psychiatric comparison subjects (n=10) completed a social-cognitive task with two confederates instructed to either include or exclude subjects from a circumscribed interaction. Evoked cerebral blood oxygenation in frontal cortex was measured using 16-channel functional near infrared spectroscopy. BPD subjects showed left medial prefrontal cortex hyperactivation during social exclusion suggesting potential dysfunction of frontolimbic circuitry.
Ruocco
Anthony C
AC
Department of Psychology, Drexel University, Philadelphia, PA, United States. anthony.ruocco@gmail.com
Medaglia
John D
JD
Tinker
Jennifer R
JR
Ayaz
Hasan
H
Forman
Evan M
EM
Newman
Cory F
CF
Williams
J Michael
JM
Hillary
Frank G
FG
Platek
Steven M
SM
Onaral
Banu
B
Chute
Douglas L
DL
D000293:Adolescent; D000328:Adult; D001883:Borderline Personality Disorder / Q000473:pathology* / Q000523:psychology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017397:Prefrontal Cortex / Q000473:pathology*; D012934:Social Isolation / Q000523:psychology*; D013055:Spectrophotometry, Infrared / Q000379:methods; D055815:Young Adult
D006454:Hemoglobins