[Effect of intra nasally applied fluticasone propionate and levocabastine on the expression of aquaporin 5 in nasal mucosa of rat with experimental allergic rhinitis].
OBJECTIVE
To investigate the expression and distribution of aquaporin 5 (AQP5) in allergic rhinitis (AR) treated by fluticasone propionate and levocabastine.


METHODS
Forty Wistar rats were divided randomly into AR (n=30) and control groups (n=10). After AR models were established, the AR rats were divided evenly into F group, L group and AR control group. Three groups were treated respectively for 28 days, then the expression of AQP5 in nasal mucous membrane were detected by immunohistochemistry assay.


RESULTS
The distribution of AQP5 was consistent in all groups. The expression of AQP5 in F group was significantly different from L group and AR group (P<0.05), while there was no significant difference between that of AR group and L group (P>0.05). The expression of AQP5 in L group was significantly different from that in control group (P<0.05).


CONCLUSIONS
High expressions of AQP5 in rat with AR indicated the positive correlation between AQP5 and AR. AQP5 might be one of pathological factors of AR concerned with glands excessive secretion and tissue edema. Glucocorticoid can down-regulate the expression of AQP5, but H1-receptor antagonist can not reduce the expression of AQP5.
Department of Otorhinolaryngology, the Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, China.
Ping
P
Lü
Suling
S
Hong
D000730:Androstadienes / Q000494:pharmacology*; D000818:Animals; D051402:Aquaporin 5 / Q000378:metabolism*; D000068298:Fluticasone; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism* / Q000473:pathology
D000730:Androstadienes; C496040:Aqp5 protein, rat; D051402:Aquaporin 5; D010880:Piperidines; D000068298:Fluticasone; C047340:levocabastine