Preventive effects of soy meal (+/- isoflavone) on spatial cognitive deficiency and body weight in an ovariectomized animal model of Parkinson's disease.
The aim of the present study was to investigate the preventive effect of 4 weeks soy meal (+/- isoflavone) on post-menopausal cognitive deficiency and body weight alteration in ovariectomized (OVX)-6-hydroxy dopamine (6-OHDA)-induced animal model of Parkinson's Disease (PD) which mimics status in menopause women. Female Wistar rats (250-300 g, 5-6 months old) were divided into 2 main groups. (1) Control; (2) OVX; included 5 subgroups that were pre-treated with 10 or 20 g soy with isoflavone in 30 g daily diet (10 and 20 groups, respectively), 10 or 20 g soy without isoflavone in 30 g daily diet (-10 and -20 groups, respectively) and 0 g soy (sham treated group) during 4 weeks after OVX. To induce animal model ofPD in main second group (OVX rats) the substantia nigra pars compacta (SNpc) was lesioned by 6-hydroxydopamine (6-OHDA) (8 microg kg(-1) 4 microL(-1) normal saline contains 0.1% ascorbate). All animals were trained in Morris water maze for evaluating the spatial learning and memory. The results indicated that pre-treatment of Parkinsonian rats with different doses of dietary soy meal (+/- isoflavone) improved the spatial learning and memory and prevents increasing the body weight after menopause significantly. Our data show that, long-duration dietary soy meal may have the potential neuroprotective effect against post-menopausal cognitive deficiency induced by degeneration of nigrostriatal dopaminergic system and constant body weight during post-menopausal life cycle.
Physiology Research Center, Department of Physiology, Faculty of Medicine, Ahvaz Jondishpour University of Medical Sciences, Ahvaz, Iran.
A
A
Sarkaki
M
M
Badavi
H
H
Aligholi
A Zand
AZ
Moghaddam
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003072:Cognition Disorders / Q000473:pathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004924:Escape Reaction; D004967:Estrogens / Q000097:blood; D005260:Female; D007529:Isoflavones / Q000627:therapeutic use*; D018782:Maze Learning / Q000187:drug effects; D010052:Ovariectomy; D020734:Parkinsonian Disorders / Q000188:drug therapy* / Q000473:pathology / Q000523:psychology; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time; D030262:Soybean Proteins; D013378:Substantia Nigra / Q000473:pathology; D013550:Swimming
D004967:Estrogens; D007529:Isoflavones; D030262:Soybean Proteins