Linking local circuit inhibition to olfactory behavior: a critical role for granule cells in olfactory discrimination.
In this issue of Neuron, Abraham et al. report a direct connection between inhibitory function and olfactory behavior. Using molecular methods to alter glutamate receptor subunit composition in olfactory bulb granule cells, the authors found a selective modulation in the time required for difficult, but not simple, olfactory discrimination tasks.
Strowbridge
Ben W
BW
Department of Neurosciences, Case Western Reserve University, Cleveland, OH 44106, USA. bens@case.edu
D000818:Animals; D004192:Discrimination, Psychological / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D009433:Neural Inhibition / Q000235:genetics / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009830:Olfactory Bulb / Q000166:cytology / Q000502:physiology*; D009833:Olfactory Pathways / Q000502:physiology; D017470:Receptors, Glutamate / Q000235:genetics / Q000378:metabolism
D017470:Receptors, Glutamate