A novel pseudo four component reaction involving homoenolate for the synthesis of gamma-aminobutyric acid (GABA) derivatives.
Homoenolate generated from alpha,beta-unsaturated aldehydes by NHC catalysis underwent facile addition to conjugated sulfonimines, generated in situ, and subsequent methanolysis to afford protected GABA derivatives stereoselectively and in high yields, thus constituting a novel pseudo four component reaction.
Nair
Vijay
V
Organic Chemistry Section, National Institute for Interdisciplinary Science and Technology (CSIR), Trivandrum, 695 019, India. vijaynair_2001@yahoo.com
Varghese
Vimal
V
Babu
Beneesh P
BP
Sinu
C R
CR
Suresh
Eringathodi
E