Interposition grafts for rectovaginal fistula repair in the New Zealand white rabbit.
OBJECTIVE
The objective was to use an animal model to study different types of interposition grafts for rectovaginal fistula repair.


METHODS
Twelve New Zealand white rabbits underwent surgical creation of a rectovaginal fistula, followed by repair. Four repair techniques were studied; three with interposition grafts and one control group without a graft. Animals were euthanized at 4-week intervals and underwent gross and histologic analysis.


RESULTS
The mean rectovaginal wall thickness was greatest in the control group (5.6 mm) and thinnest in the autologous rectus fascia (4.2 mm) and porcine small intestine submucosa (5.1 mm) groups. The polypropylene graft had a mean thickness of 5.4 mm and elicited a strong, protracted inflammatory response. All fistulas were successfully closed except one porcine small intestine submucosa repair.


CONCLUSIONS
There is no benefit from interposition graft use for rectovaginal fistula repair in our New Zealand white rabbit model.
Aungst
Matthew J
MJ
Division of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics and Gynecology, Walter Reed Army Medical Center, Bldg 2, Rm 2J06, 6900 Georgia Avenue, Washington, DC 20307, USA. Matt.Aungst@yahoo.com
Bearss
Jeremy J
JJ
Lewis
Bridget S
BS
Fischer
John R
JR
Bonhage
Michael R
MR
Wright
Johnnie
J
D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects; D001705:Bioprosthesis / Q000009:adverse effects*; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects / Q000379:methods*; D007249:Inflammation / Q000209:etiology* / Q000473:pathology; D007413:Intestinal Mucosa / Q000637:transplantation; D011126:Polypropylenes / Q000009:adverse effects; D011817:Rabbits; D012006:Rectovaginal Fistula / Q000601:surgery*; D014182:Transplantation, Autologous / Q000009:adverse effects
D001672:Biocompatible Materials; D011126:Polypropylenes