Thymidine kinase and deoxycytidine kinase in HIV-infected children.
It has been demonstrated that HIV infection may affect the levels of thymidine kinase (TK) and deoxycytidine kinase (dCK) in peripheral blood mononuclear cells from HIV infected adults. The aim of this study was to examine the effect of HIV infection and/or antiretroviral therapy on the activity of the above enzymes in HIV-infected children. The results showed that an inter-individual variability in TK and dCK activities does exist in both HIV infected and uninfected children. TK and dCK levels in PBMC from HIV infected and non infected children did not significantly differ. Furthermore, the therapeutic regimen, including zidovudine, does not seem to affect TK activity.
Department of Experimental Medicine, Virology Section, "Sapienza" University of Rome, Italy.
Francesca
F
Falasca
Paola
P
Maida
Arianna
A
Boni
Stefania
S
Bernardi
Laura
L
Cursi
Bambina
B
Rizzo
Guido
G
Antonelli
Guido Castelli
GC
Gattinara
Ombretta
O
Turriziani
D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003842:Deoxycytidine Kinase / Q000378:metabolism*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000201:enzymology* / Q000821:virology; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D007223:Infant; D007963:Leukocytes, Mononuclear / Q000201:enzymology*; D008297:Male; D013937:Thymidine Kinase / Q000378:metabolism*; D015215:Zidovudine / Q000627:therapeutic use
D019380:Anti-HIV Agents; D015215:Zidovudine; D013937:Thymidine Kinase; D003842:Deoxycytidine Kinase