Growth and aging: a common molecular mechanism.
It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-related diseases. Thus, the nutrient-sensing and growth-promoting TOR signaling pathway may provide a molecular link between growth and aging that is universal from yeast to human.
Blagosklonny
Mikhail V
MV
Roswell Park Cancer Institute, Buffalo, NY 14263, USA. blagosklonny@oncotarget.com
Hall
Michael N
MN
D000375:Aging / Q000502:physiology*; D000818:Animals; D005075:Biological Evolution; D004734:Energy Metabolism; D006801:Humans; D015398:Signal Transduction / Q000235:genetics* / Q000502:physiology*