Acid and base degraded products of ketorolac.
The stability of ketorolac tromethamine was investigated in acid (0.5M HCl) and alkaline conditions (0.5M NaOH), using the same procedure reported by Devarajan et al. [2]. The acid and base degradation products were identified by liquid chromatography-mass spectrometry (LC-MS).
Salaris
Margherita
M
Istituto Zooprofilattico della Sardegna, Italy.
Nieddu
Maria
M
Rubattu
Nicola
N
Testa
Cecilia
C
Luongo
Elvira
E
Rimoli
Maria Grazia
MG
Boatto
Gianpiero
G
D000143:Acids / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis / Q000737:chemistry*; D002853:Chromatography, Liquid / Q000379:methods; D004355:Drug Stability; D006358:Hot Temperature; D006851:Hydrochloric Acid / Q000737:chemistry; D006868:Hydrolysis; D020910:Ketorolac / Q000032:analysis / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods; D000432:Methanol / Q000737:chemistry; D015394:Molecular Structure; D008970:Molecular Weight; D012015:Reference Standards; D012972:Sodium Hydroxide / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013997:Time Factors
D000143:Acids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D012997:Solvents; D012972:Sodium Hydroxide; D006851:Hydrochloric Acid; D000432:Methanol; D020910:Ketorolac