Control to range for diabetes: functionality and modular architecture.
BACKGROUND
Closed-loop control of type 1 diabetes is receiving increasing attention due to advancement in glucose sensor and insulin pump technology. Here the function and structure of a class of control algorithms designed to exert control to range, defined as insulin treatment optimizing glycemia within a predefined target range by preventing extreme glucose fluctuations, are studied.


METHODS
The main contribution of the article is definition of a modular architecture for control to range. Emphasis is on system specifications rather than algorithmic realization. The key system architecture elements are two interacting modules: range correction module, which assesses the risk for incipient hyper- or hypoglycemia and adjusts insulin rate accordingly, and safety supervision module, which assesses the risk for hypoglycemia and attenuates or discontinues insulin delivery when necessary. The novel engineering concept of range correction module is that algorithm action is relative to a nominal open-loop strategy-a predefined combination of basal rate and boluses believed to be optimal under nominal conditions.


RESULTS
A proof of concept of the feasibility of our control-to-range strategy is illustrated by using a prototypal implementation tested in silico on patient use cases. These functional and architectural distinctions provide several advantages, including (i) significant insulin delivery corrections are only made if relevant risks are detected; (ii) drawbacks of integral action are avoided, e.g., undershoots with consequent hypoglycemic risks; (iii) a simple linear model is sufficient and complex algorithmic constraints are replaced by safety supervision; and (iv) the nominal profile provides straightforward individualization for each patient.


CONCLUSIONS
We believe that the modular control-to-range system is the best approach to incremental development, regulatory approval, industrial deployment, and clinical acceptance of closed-loop control for diabetes.
Department of Psychiatry and Neurobehavioral Sciences and Department of Systems and Information Engineering, University of Virginia, Charlottesville, Virginia, USA.
Boris
B
Kovatchev
Stephen
S
Patek
Eyal
E
Dassau
Francis J
FJ
Doyle
Lalo
L
Magni
Giuseppe
G
De Nicolao
Claudio
C
Cobelli
D000328:Adult; D000465:Algorithms; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D015190:Blood Glucose Self-Monitoring / Q000295:instrumentation; D003198:Computer Simulation; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D003936:Diagnosis, Computer-Assisted; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000378:metabolism; D004360:Drug Therapy, Computer-Assisted; D005240:Feasibility Studies; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D007328:Insulin / Q000008:administration & dosage* / Q000009:adverse effects; D007332:Insulin Infusion Systems; D016014:Linear Models; D008954:Models, Biological; D019397:Pancreas, Artificial; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D018511:Systems Integration; D013997:Time Factors; D016896:Treatment Outcome
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007004:Hypoglycemic Agents; D007328:Insulin