Luteoma-induced fetal virilization.
A pregnancy luteoma represents an unusual response of ovarian stromal cells to the altered hormonal levels of pregnancy. It is a distinctive non-neoplastic lesion characterized by solid proliferations of luteinized cells resulting in a tumor-like ovarian enlargement. Most patients are asymptomatic; the ovarian enlargement is usually discovered incidentally at cesarean section or during postpartum tubal ligation. We report a typical case that we found at cesarean section to be associated with a virilized infant who manifested clitoromegaly and labial fusion. We detected an increased level of testosterone in the maternal patient. We concluded that the ovarian luteoma induced the fetal virilization.
Ugaki
Hiromi
H
Department of Obstetrics and Gynecology, Osaka University, Graduate School of Medicine, Osaka, Japan. hirohiromimi@hotmail.com
Enomoto
Takayuki
T
Tokugawa
Yoshihiro
Y
Kimura
Tadashi
T
D000328:Adult; D002585:Cesarean Section; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018311:Luteoma / Q000097:blood / Q000150:complications*; D008431:Maternal-Fetal Exchange; D010051:Ovarian Neoplasms / Q000097:blood / Q000150:complications*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000175:diagnosis; D013739:Testosterone / Q000097:blood; D014770:Virilism / Q000097:blood / Q000209:etiology*
D013739:Testosterone