Similar incretin secretion in obese and non-obese Japanese subjects with type 2 diabetes.
Incretin secretion and effect on insulin secretion are not fully understood in patients with type 2 diabetes. We investigated incretin and insulin secretion after meal intake in obese and non-obese Japanese patients with type 2 diabetes compared to non-diabetic subjects. Nine patients with type 2 diabetes and 5 non-diabetic subjects were recruited for this study. Five diabetic patients were obese (BMI > or = 25) and 4 patients were non-obese (BMI < 25). In response to a mixed meal test, the levels of immunoreactive insulin during 15-90 min and C-peptide during 0-180 min in non-obese patients were significantly lower than those in obese patients. Total GLP-1 and active GIP levels showed no significant difference between obese and non-obese patients throughout the meal tolerance test. In addition, there were no significant differences between diabetic patients and non-diabetic subjects. In conclusion, incretin secretion does not differ between Japanese obese and non-obese patients with type 2 diabetes and non-diabetic subjects.
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Suita, Japan.
Junji
J
Kozawa
Kohei
K
Okita
Akihisa
A
Imagawa
Hiromi
H
Iwahashi
Jens J
JJ
Holst
Kazuya
K
Yamagata
Iichiro
I
Shimomura
D015992:Body Mass Index; D002096:C-Peptide / Q000097:blood / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000378:metabolism*; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D006801:Humans; D054795:Incretins / Q000097:blood / Q000378:metabolism*; D007328:Insulin / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000378:metabolism*
D002096:C-Peptide; D054795:Incretins; D007328:Insulin; D052216:Glucagon-Like Peptide 1