Mesoporous silica microparticles enhance the cytotoxicity of anticancer platinum drugs.
We report on the endocytosis and the time-dependent enhanced cytotoxicity of anticancer platinum drugs when the drugs are combined with (or loaded into) one of the two most common types of mesoporous silica materials, MCM-41 or SBA-15. The anticancer drug cisplatin and its isomer transplatin, when loaded on MCM-41 and SBA-15 microparticles, were less cytotoxic to leukemia cells than the drugs alone after 12 h exposure. However, the drug-loaded microparticles exhibited unprecedented enhanced cytotoxicity to the cancerous cells after 24 h of exposure. This cytotoxicity of the drug-loaded microparticles was even higher than of the pure drugs in solutions, suggesting that mesoporous silica microparticles loaded with cisplatin or transplatin enabled a localized intracellular release of the platinum compounds and possibly also facilitated the drug's hydrolysis, enhancing the desired cytotoxic effect.
Department of Chemistry, Syracuse University, CST 1-014, Syracuse, NY 13244, USA.
Zhimin
Z
Tao
Bonnie
B
Toms
Jerry
J
Goodisman
Tewodros
T
Asefa
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002945:Cisplatin / Q000737:chemistry* / Q000494:pharmacology*; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism; D004705:Endocytosis; D006801:Humans; D019169:Jurkat Cells; D046529:Microscopy, Electron, Transmission; D009584:Nitrogen / Q000737:chemistry; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry* / Q000378:metabolism; D013997:Time Factors
D000970:Antineoplastic Agents; D004337:Drug Carriers; C509968:MCM-41; C509969:SBA-15; C034697:transplatin; D012822:Silicon Dioxide; D009584:Nitrogen; D002945:Cisplatin