[Effect of skeletal muscle contraction on bone capillary permeability: an experimental study in rabbits].
OBJECTIVE
To assess the effect of muscle contraction on bone capillary permeability.


METHODS
Thirty female New Zealand white rabbits were randomly divided into the experimental and control groups (n=15). The bone chambers were implanted medially into the right tibiae of the rabbit, and in the experimental group, the rabbits were stimulated by transcutaneous electrical nerve stimulator (TENS) at 4 Hz (1 h/day, 6 days/week) starting from week 2. From week 3, intravital microscopic observation was carried out weekly till week 10, and the vasculature in the tibiae was observed under fluorescent microscope with FITC and RITC staining. All the images were analyzed by Metamorph program.


RESULTS
The bone capillary permeability increased significantly in the experimental group.


CONCLUSIONS
Skeletal muscle contraction can increase the capillary permeability.
Department of Stomatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Yu
Y
Zhnag
Dan
D
Jin
Li-chao
LC
Wang
Yu
Y
Qin
D000818:Animals; D002199:Capillary Permeability / Q000502:physiology*; D005260:Female; D020007:Implants, Experimental; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D011817:Rabbits; D011897:Random Allocation; D013977:Tibia / Q000098:blood supply* / Q000601:surgery*; D004561:Transcutaneous Electric Nerve Stimulation