Bimodal gene expression patterns in breast cancer.
We identified a set of genes with an unexpected bimodal distribution among breast cancer patients in multiple studies. The property of bimodality seems to be common, as these genes were found on multiple microarray platforms and in studies with different end-points and patient cohorts. Bimodal genes tend to cluster into small groups of four to six genes with synchronised expression within the group (but not between the groups), which makes them good candidates for robust conditional descriptors. The groups tend to form concise network modules underlying their function in cancerogenesis of breast neoplasms.
Bessarabova
Marina
M
Russian Academy of Sciences, Vavilov Institute for General Genetics, ul. Gubkina, 3, Moscow, Russia. bessarabova@genego.com
Kirillov
Eugene
E
Shi
Weiwei
W
Bugrim
Andrej
A
Nikolsky
Yuri
Y
Nikolskaya
Tatiana
T
D056667:Biometric Identification; D001943:Breast Neoplasms / Q000235:genetics*; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans