Synthesis and biological activity of n-butylphthalide derivatives.
A series of n-butylphthalide derivatives were designed and synthesized. The in vitro activities of these compounds were evaluated by a resting tension of isolated rat thoracic aorta ring assay. Compounds 4g and 4i were found to be more active than n-butylphthalide.
Wang
Wei
W
College of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, PR China.
Cha
Xue-Xiang
XX
Reiner
John
J
Gao
Yuan
Y
Qiao
Hai-Ling
HL
Shen
Jia-Xiang
JX
Chang
Jun-Biao
JB
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000378:metabolism; D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D051379:Mice; D015394:Molecular Structure; D051381:Rats; D013237:Stereoisomerism; D014665:Vasodilator Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D001572:Benzofurans; D014665:Vasodilator Agents; C027125:3-n-butylphthalide