[Study of 17 immune cytokines in the peripheral blood of premature infants with chronic lung disease].
OBJECTIVE
To explore the immunomechanism of chronic lung disease (CLD) in premature infants by investigating the changes of 17 cytokines.


METHODS
Twenty-six preterm neonates who had been in the NICU for over 28 days were divided into CLD group (n=14) and control group consisting of 12 preterm neonates. Seventeen cytokines, namely interleukin 1b (IL-1b), IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, granulocyte-macrophage colony-stimulating factor, interferon-gamma, tumour necrosis factor alpha, granulocyte colony-stimulating factor, monocyte chemoattractant protein 1, and macrophage inflammatory protein-1b were detected in a single sample of peripheral blood by multi-plex technology (Bio-plex).


RESULTS
There were no significant differences in the level of the 17 cytokines between the two groups (P>0.05).


CONCLUSIONS
The cytokines examined may not be involved in the later period pathogenesis of CLD.
Luo
Ying
Y
Department of Neonatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Huang
Wei-min
WM
D002908:Chronic Disease; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007371:Interferon-gamma / Q000097:blood; D007378:Interleukins / Q000097:blood; D008171:Lung Diseases / Q000097:blood* / Q000276:immunology; D008297:Male; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D016207:Cytokines; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma