'Party pill' drugs--BZP and TFMPP.
BZP and TFMPP are amphetamine-like recreational drugs and the major active components of 'party pills'. The pharmacodynamic effects of these neurally active drugs are thought to be dependent on their activity at DA and 5-HT receptors and several studies report drug-drug interactions at a pharmacodynamic level. Their metabolism involves the hepatic P450 enzymes CYP2D6, CYP1A2 and CYP3A4 resulting in inhibited metabolism of other drugs and medicines, as well as compromised metabolism in poor metabolisers for CYP2D6. Basic pharmacokinetic properties are described for both BZP and TFMPP when taken alone and in combination. Several studies have shown that these drugs cause several drug-drug interactions.
Antia
Ustana
U
School of Pharmacy, University of Auckland, Private Bag 92019, Auckland, New Zealand. u.antia@auckland.ac.nz
Tingle
Malcolm D
MD
Russell
Bruce R
BR
D004304:Dosage Forms; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D008297:Male; D009520:New Zealand; D010879:Piperazines / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D018570:Risk Assessment; D017366:Serotonin Receptor Agonists / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D019966:Substance-Related Disorders / Q000517:prevention & control*
D004304:Dosage Forms; D013287:Illicit Drugs; D010879:Piperazines; D017366:Serotonin Receptor Agonists; C018406:1-(3-trifluoromethylphenyl)piperazine