Therapeutic effect of Linum usitatissimum (flaxseed/linseed) fixed oil on acute and chronic arthritic models in albino rats.
The present study was undertaken to assess the activity/anti-inflammatory potential of Linum usitatissimum fixed oil against castor oil-induced diarrhoea, turpentine oil-induced joint oedema, formaldehyde and Complete Freund's Adjuvant (CFA)-induced arthritis in Wistar albino rats. The oil intraperitoneally, significantly inhibited the castor oil-induced diarrhoea and turpentine oil-induced exudative joint oedema in a dose-dependent manner. Significant inhibitory effect of L. usitatissimum fixed oil was observed in formaldehyde-induced proliferative global oedematous arthritis when given intraperitoneally, with significant checking of the serum glutamic oxaloacetic acid transaminase and serum glutamic pyruvic acid transaminase. Further, L. usitatissimum fixed oil showed a significant dose-dependent protective effect against CFA-induced arthritis as well. Secondary lesions produced by CFA due to a delayed hypersensitivity reaction were also reduced in a significant manner. Anti-inflammatory activity of L. usitatissimum fixed oil can be attributed to the presence of alpha linolenic acid (57.38%, an omega-3 fatty acid, 18:3, n-3) having dual inhibitory effect on arachidonate metabolism resulting in suppressed production of proinflammatory n-6 eicosanoids (PGE(2), LTB(4)) and diminished vascular permeability. These observations suggest possible therapeutic potential of L. usitatissimum fixed oil in inflammatory disorders like rheumatoid arthritis.
Kaithwas
Gaurav
G
Department of Pharmaceutical Sciences, FHMS, Allahabad Agricultural Institute-Deemed University, Allahabad, Uttar Pradesh, India.
Majumdar
Dipak K
DK
D000208:Acute Disease; D000410:Alanine Transaminase / Q000097:blood; D000417:Albinism; D000818:Animals; D001169:Arthritis, Experimental / Q000139:chemically induced / Q000000981:diagnostic imaging / Q000473:pathology / Q000517:prevention & control*; D001219:Aspartate Aminotransferases / Q000097:blood; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D002368:Castor Oil / Q000008:administration & dosage / Q000494:pharmacology; D002908:Chronic Disease; D003967:Diarrhea / Q000139:chemically induced / Q000517:prevention & control; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D019597:Flax / Q000737:chemistry*; D005528:Foot / Q000473:pathology; D005557:Formaldehyde / Q000008:administration & dosage / Q000494:pharmacology; D005620:Freund's Adjuvant / Q000008:administration & dosage / Q000494:pharmacology; D006614:Hindlimb / Q000187:drug effects / Q000473:pathology; D007596:Joints / Q000187:drug effects / Q000473:pathology; D008043:Linseed Oil / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011859:Radiography; D051381:Rats; D017208:Rats, Wistar; D014425:Turpentine / Q000008:administration & dosage / Q000494:pharmacology
D005557:Formaldehyde; D008043:Linseed Oil; D002368:Castor Oil; D005620:Freund's Adjuvant; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001241:Aspirin; D014425:Turpentine