Selenium and hormone interactions in female patients with Hashimoto disease and healthy subjects.
OBJECTIVE
To examine the correlation structure of parameters expressing selenium status, sex hormones secretion and thyroid function in a group of patients with Hashimoto disease and healthy female subjects.


METHODS
Partial Least Square modeling was applied to parameters under study.


RESULTS
The correlations between relevant parameters were confirmed. Selenoenzyme glutathione peroxidase (GPX3) an progesterone played the most significant roles among factors contributing to thyroid stimulating hormone and free thyroxine regulation. Additionally, a correlation between GPX3 and estradiol was also observed which is in agreement with results reported by other authors. Patients with Hashimoto disease had lower glutathione peroxidase activities than healthy subjects.


CONCLUSIONS
The integrated multivariate approach applied to a new group of patients dissimilar to the previous one, was validated by statistical adequacy as well ass meaningful interpretation.
Zagrodzki
Paweł
P
Department of Food Chemistry and Nutrition, Medical College, Jagiellonian University, Kraków, Poland. pawel.zagrodzki@ifj.edu.pl
Przybylik-Mazurek
Elwira
E
D000328:Adult; D001323:Autoantibodies / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D050031:Hashimoto Disease / Q000097:blood*; D006801:Humans; D016018:Least-Squares Analysis; D007986:Luteinizing Hormone / Q000097:blood; D011374:Progesterone / Q000097:blood; D012643:Selenium / Q000097:blood*; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood
D001323:Autoantibodies; D012739:Gonadal Steroid Hormones; D013963:Thyroid Hormones; C056626:thyroid microsomal antibodies; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D005979:Glutathione Peroxidase; D012643:Selenium; D013974:Thyroxine