KIT masters mast cells in kids, too.
Adult mastocytosis is usually persistent and caused by c-KIT codon 816-activating mutations. Pediatric mastocytosis is often transient, and the molecular mechanism driving mast cell proliferation in pediatric cases remains unclear. In this issue, Bodemer et al. report novel c-KIT mutations in a large percentage of pediatric cases, identifying both similarities and fundamental differences in the mechanisms causing adult and pediatric mastocytosis.
Kambe
Naotomo
N
Department of Dermatology, Chiba University Graduate School of Medicine, Chiba, Japan.
Longley
B Jack
BJ
Miyachi
Yoshiki
Y
Kabashima
Kenji
K
D000328:Adult; D000818:Animals; D002455:Cell Division / Q000502:physiology; D002648:Child; D006801:Humans; D008407:Mast Cells / Q000473:pathology* / Q000502:physiology*; D034701:Mastocytosis, Cutaneous / Q000235:genetics* / Q000473:pathology*; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*
D019009:Proto-Oncogene Proteins c-kit