Trigochinins A-C: three new daphnane-type diterpenes from Trigonostemon chinensis.
Three highly oxygenated new diterpenes, trigochinins A-C (1-3) were isolated from Trigonostemon chinensis. Their structures with the absolute configuration were determined by a spectroscopic method, X-ray crystallography, and CD analysis. This study suggested the revision of the C-6 stereochemistry of trigonothyrins A-C reported quite recently. Compound 3 showed significant inhibition against MET tyrosine kinase activity with a IC(50) value of 1.95 microM.
State Key Laboratory of Drug Research, Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, People's Republic of China.
Hua-Dong
HD
Chen
Sheng-Ping
SP
Yang
Xiu-Feng
XF
He
Jing
J
Ai
Zhen-Kai
ZK
Liu
Hong-Bing
HB
Liu
Mei-Yu
MY
Geng
Jian-Min
JM
Yue
D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D013237:Stereoisomerism
D004224:Diterpenes; D047428:Protein Kinase Inhibitors; C549983:trigochinin A; C549984:trigochinin B; C549985:trigochinin C; D011505:Protein-Tyrosine Kinases