An activation marker finds a function.
In this issue of Immunity, Baaten et al. (2010) describe a previously unknown role for CD44 in counteracting Fas-mediated apoptosis of Th1 effector cells during clonal expansion and allowing their entry into the memory pool.
Mitchell
Diana M
DM
Department of Pathology, University of Utah, Salt Lake City, UT 84112, USA.
Williams
Matthew A
MA
D000818:Animals; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*