Is bactibilia a predictor of poor outcome of pancreaticoduodenectomy?
BACKGROUND
Although bile infection has been proposed to increase infective complications following pancreaticoduodenectomy, its association with infective complications and non-infective complications like pancreatic fistula is still controversial.


METHODS
Seventy-six patients who had undergone pancreaticoduodenectomy between July 2007 and December 2008 were included in a prospective database and their data analyzed. In all patients intraoperative bile from the bile duct was cultured. Preoperative, intra-operative, and post-operative variables were recorded and analyzed.


RESULTS
Bile culture showed positive growth in 35 patients and negative growth in 41. Twenty patients in the positive group underwent ERCP and stenting. The patients with a positive bile culture had a higher incidence of infective complications including intra-abdominal abscess (n=8), wound infection (n=27), bacteremia (n=10), and renal insufficiency (n=9). There was no increase in the rate of non-infective complications of pancreaticoduodenectomy including pancreatic fistula (n=7), delayed gastric emptying (n=9), and post-operative hemorrhage (n=3). The hospital stay was significantly prolonged in the patients with a positive bile culture (P=0.0002).


CONCLUSIONS
Pre-operative biliary drainage is significantly associated with bile infection, and bile infection increases the overall rates of infective complications and renal insufficiency. Because of the high incidence of complications is associated with infected bile, routine intra-operative bile culture is recommended in patients undergoing pancreaticoduodenectomy. Pre-operative prophylaxis is dependent on sensitivity of cases to perioperative antibiotics and intra-operative bile culture report. Because of its significant association with infected bile, biliary stenting should be used in strictly selected cases.
Institute of Surgical Gastroenterology and Liver Transplantation, New Gastroenterology Block, Government Stanley Medical College Hospital, Chennai 600 001, India.
Sivanpillay Mahadevan
SM
Sivaraj
Velayutham
V
Vimalraj
Palanichamy
P
Saravanaboopathy
Shanmugasundaram
S
Rajendran
Sathyanesan
S
Jeswanth
Palaniappan
P
Ravichandran
Rosy
R
Vennilla
Rajagopalan
R
Surendran
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001646:Bile / Q000382:microbiology*; D001660:Biliary Tract Diseases / Q000209:etiology* / Q000382:microbiology* / Q000517:prevention & control; D004322:Drainage / Q000009:adverse effects; D005260:Female; D006470:Hemorrhage / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D010185:Pancreatic Fistula / Q000453:epidemiology; D016577:Pancreaticoduodenectomy; D011183:Postoperative Complications; D011237:Predictive Value of Tests; D011300:Preoperative Care; D011379:Prognosis; D011446:Prospective Studies; D051437:Renal Insufficiency / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors
D000900:Anti-Bacterial Agents