The role of mucin-type O-glycans in eukaryotic development.
Newly emerging genetic studies have revealed that a subset of the family of glycosyltransferases responsible for the formation of mucin-type O glycans is essential for normal development. As additional genetic, biochemical and physical tools are developed to interrogate the complex structure and surface location of this under-studied class of carbohydrate, no doubt additional roles will be elucidated.
Tabak
Lawrence A
LA
Section on Biological Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. tabakl@mail.nih.gov
D056890:Eukaryota / Q000502:physiology*; D006031:Glycosylation; D016695:Glycosyltransferases / Q000378:metabolism; D009077:Mucins / Q000737:chemistry / Q000378:metabolism*; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism*
D009077:Mucins; D011134:Polysaccharides; D016695:Glycosyltransferases