The establishment of a new mouse model with orthotopic esophageal cancer showing the esophageal stricture.
We established a promising new experimental animal model with an orthotopic xenograft of esophageal cancer that successfully represents poor oral intake, a major clinical feature of esophageal cancer. The advantage of this model is that no surgical technique is required, only the injection of a cell suspension by a needle and syringe via the esophageal lumen from the mouth, which provides a high reproducibility of tumor implantation and a rapid progress of outcome. We propose that this model is useful to study cancer-related outcomes and for developing new therapies for esophageal cancer, and we expect it to make a contribution to clinical practice.
Department of Gastroenterological Surgery, Transplant, and Surgical Oncology, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Toshiaki
T
Ohara
Munenori
M
Takaoka
Kazufumi
K
Sakurama
Kaori
K
Nagaishi
Haruo
H
Takeda
Yasuhiro
Y
Shirakawa
Tomoki
T
Yamatsuji
Takeshi
T
Nagasaka
Junji
J
Matsuoka
Noriaki
N
Tanaka
Yoshio
Y
Naomoto
D000818:Animals; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D004435:Eating; D004938:Esophageal Neoplasms / Q000473:pathology* / Q000503:physiopathology; D004940:Esophageal Stenosis / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation / Q000379:methods*; D014183:Transplantation, Heterologous