Stimulation of protective and cross-protective immunity against influenza B virus after adjuvant mucosal immunization of mice.
Intratracheal immunization of mice with inactivated influenza B virus and delipidated Bacillus firmus as adjuvant increases protection of mice against infection with the homologous virus strain and induces cross-protection: mice immunized by influenza virus B/Yamanashi 166/98 were protected even against phylogenetically distant virus drift variant B/Lee/40 lethal for mice.
Institute of Immunology and Microbiology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic. lprok@lf1.cuni.cz
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L
Prokesová
P
P
Zanvit
M
M
Havlícková
J
J
Tácner
M
M
Jirkovská
P
P
Petrásková
O
O
Novotná
D
D
Cechová
J
J
Julák
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000280:Administration, Inhalation; D000818:Animals; D001407:Bacillus / Q000276:immunology; D056738:Cross Protection; D005260:Female; D007114:Immunization / Q000379:methods*; D009981:Influenza B virus / Q000276:immunology*; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000517:prevention & control; D016019:Survival Analysis; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000276:immunology
D000276:Adjuvants, Immunologic; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated