Burden of malaria during pregnancy at the time of IPTp/SP implementation in Gabon.
The new recommendations to prevent malaria in pregnant women have recently been implemented in Gabon. There is little information on the pregnancy indicators that are useful for their evaluation. A cross-sectional study for the assessment of the prevalence of peripheral, placental, and cord malaria and anemia among delivering women was performed at the largest public hospital of Gabon. Malaria prevalence was 34.4%, 53.6%, and 18.2% for maternal peripheral, placental, and cord blood respectively, with no difference between primigravidae and multigravidae. Submicroscopic infections were frequent and concerned all the positive cord samples. Maternal peripheral, late placental, and cord infections were all associated with a reduced mean birth weight in primigravidae (P = 0.02). Anemia prevalence was 53%, low birth rate was 13%, and prematurity was 25%. The use of intermittent preventive treatment with sulfadoxine-pyrimethamine (greater than or equal to one dose) combined with bed net was associated with a reduction in infection only in multigravidae and with a reduced risk of maternal anemia.
Department of Parasitology-Mycology and Tropical Medicine, Faculty of Medicine, Université des Sciences de la Santé, Libreville, Gabon. mariellebouyou@gmail.com
Marielle K
MK
Bouyou-Akotet
Solange
S
Nzenze-Afene
Edgard B
EB
Ngoungou
Eric
E
Kendjo
Mathieu
M
Owono-Medang
Jean-Bernard
JB
Lekana-Douki
Ghislaine
G
Obono-Obiang
Mathieu
M
Mounanga
Maryvonne
M
Kombila
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000740:Anemia / Q000453:epidemiology; D000962:Antimalarials / Q000008:administration & dosage / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D004338:Drug Combinations; D005260:Female; D005681:Gabon / Q000453:epidemiology; D006801:Humans; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000469:parasitology*; D057147:Mosquito Nets; D016017:Odds Ratio; D010920:Placenta / Q000469:parasitology; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000453:epidemiology; D015597:Pregnancy Complications, Parasitic / Q000453:epidemiology*; D015995:Prevalence; D011739:Pyrimethamine / Q000008:administration & dosage* / Q000627:therapeutic use*; D012307:Risk Factors; D013413:Sulfadoxine / Q000008:administration & dosage* / Q000627:therapeutic use*; D055815:Young Adult
D000962:Antimalarials; D004338:Drug Combinations; C001205:fanasil, pyrimethamine drug combination; D013413:Sulfadoxine; D011739:Pyrimethamine