Diagnosis and treatment of endothelial dysfunction in cardiovascular disease.
Vascular endothelial dysfunction reflected by reduced nitric oxide (NO) availability is certainly the causative factor or promoting mechanism of arteriosclerosis. It is necessary to detect endothelial dysfunction at an early stage using appropriate methods, and to choose a treatment for the recovery of endothelial function. There are nonpharmacological and pharmacological therapies to attain endothelial repair. The former includes body weight reduction, aerobic exercise, and restriction of salt intake, while the latter includes the use of renin-angiotensin system inhibitors, calcium antagonists, some types of beta blockers, statins, erythropoietin, tetrahydrobiopterin, and antioxidants. These therapies are intended to increase NO synthase activity and NO release, inhibit NO degradation, and enhance the activity of endothelial progenitor cells.
Hirata
Yasunobu
Y
Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo.
Nagata
Daisuke
D
Suzuki
Etsu
E
Nishimatsu
Hiroaki
H
Suzuki
Jun-Ichi
J
Nagai
Ryozo
R
D001161:Arteriosclerosis / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D009569:Nitric Oxide / Q000502:physiology; D011379:Prognosis; D014664:Vasodilation
D009569:Nitric Oxide