Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii.
A new bisindole alkaloid, bisleuconothine A (1) consisting of an eburnane-aspidosperma type skeleton, was isolated from the bark of Leuconotis griffithii. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and X-ray analysis. Bisleuconothine A (1) showed cell growth inhibitory activity against various human cancer cell lines.
Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
Yusuke
Y
Hirasawa
Tomokazu
T
Shoji
Takashi
T
Arai
Alfarius E
AE
Nugroho
Jun
J
Deguchi
Takahiro
T
Hosoya
Nahoko
N
Uchiyama
Yukihiro
Y
Goda
Khalijah
K
Awang
A Hamid A
AH
Hadi
Motoo
M
Shiro
Hiroshi
H
Morita
D029062:Apocynaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular
D026121:Indole Alkaloids; C550713:bisleuconothine A