The efficacy of multiple-dose methotrexate treatment for unruptured tubal ectopic pregnancy and conversion rate to surgery: a study on 294 cases.
In this prospective study 294 patients diagnosed with ectopic pregnancy (EP) were treated with multiple-dose methotrexate (MTX) to determine the conversion rate to surgery. We concluded that multiple-dose MTX treatment had a low success rate, and the success rate was not related to initial b-hCG value; it was more related to the size of gestational mass before treatment.
Department of Obstetrics and Gynecology, Meram Medicine Faculty, Selcuk University, Akyokus, 42080, Konya, Turkey. drobalci@yahoo.com
Osman
O
Balci
Suna
S
Ozdemir
Alaa S
AS
Mahmoud
Ali
A
Acar
Mehmet C
MC
Colakoglu
D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage; D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004622:Embryo, Mammalian / Q000473:pathology; D005187:Fallopian Tubes / Q000187:drug effects / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D013509:Gynecologic Surgical Procedures / Q000706:statistics & numerical data*; D006801:Humans; D007273:Injections, Intramuscular; D008727:Methotrexate / Q000008:administration & dosage*; D009929:Organ Size; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000188:drug therapy* / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D017211:Treatment Failure; D016896:Treatment Outcome
D000020:Abortifacient Agents, Nonsteroidal; D008727:Methotrexate