Peroxisome proliferator-activated receptor-gamma and its coactivator-1alpha gene polymorphisms in Korean women with polycystic ovary syndrome.
OBJECTIVE
To investigate whether the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) Pro12Ala and the PPAR-gamma coactivator-1alpha (PGC-1alpha) Gly482Ser polymorphisms were associated with polycystic ovary syndrome (PCOS).


METHODS
Genetic analyses of the PPAR-gamma Pro12Ala and the PGC-1alpha Gly482Ser polymorphisms were performed in 184 patients with PCOS and 256 controls. Hormone levels, biochemical and clinical features were analyzed according to these polymorphisms.


RESULTS
Neither the PPAR-gammaPro12Ala nor the PGC-1alpha Gly482Ser polymorphism showed significant differences in genotypic distribution between women with PCOS and controls. In PCOS patients, women with the non-Pro/Pro genotypes of the PPAR-gamma Pro12Ala polymorphism showed statistically significantly higher HDL levels than those with the Pro/Pro genotype (p = 0.002). PCOS patients who had the Ser/Ser genotype of the PGC-1alpha Gly482Ser polymorphism had significantly higher levels of postprandial 2-hour insulin than those with the Gly/Ser genotype (p = 0.045).


CONCLUSIONS
Neither the PPAR-gammaPro12Ala nor the PGC-1alpha Gly482Ser polymorphism were supposed to be susceptible genes in PCOS. However, in PCOS patients, the PPAR-gammaPro12Ala and the PGC-1alpha Gly482Ser polymorphism may modulate the concentrations of serum HDL levels and postprandial 2-hour insulin level, respectively.
Maria Fertility Hospital, Seoul National University College of Medicine, 28 Yeongun-Dong, Jongno-Gu, Seoul, South Korea.
Soo Jin
SJ
Chae
Jin Ju
JJ
Kim
Young Min
YM
Choi
Jong Mee
JM
Kim
Young Min
YM
Cho
Shin Yong
SY
Moon
D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood; D005260:Female; D005838:Genotype; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D007328:Insulin / Q000097:blood; D047495:PPAR gamma / Q000235:genetics*; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D019518:Postprandial Period / Q000502:physiology; D056910:Republic of Korea; D014157:Transcription Factors / Q000235:genetics*; D055815:Young Adult
D008076:Cholesterol, HDL; D006360:Heat-Shock Proteins; D007328:Insulin; D047495:PPAR gamma; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors