The impact of insulin sensitisers on lung function in patients with chronic obstructive pulmonary disease and diabetes.
METHODS
It has been reported that diabetes mellitus (DM) is associated with poor pulmonary function, which could be explained by insulin resistance.


OBJECTIVE
To evaluate whether insulin sensitisers (ISs) have beneficial effects on lung function in patients with chronic obstructive pulmonary disease (COPD) and DM.


METHODS
This retrospective study included patients with both COPD and DM who attended Seoul National University Hospital for treatment between 1 January 2000 and 31 August 2007. They were treated with inhalers for COPD and oral hypoglycaemia agents, including ISs or insulin, for DM. The primary outcome was a change in lung function in spirometric examinations.


RESULTS
Among 61 patients enrolled, 32 were in the no IS group, while 29 were in the IS group. On multivariable regression analysis, the IS group showed a significantly greater change in forced vital capacity (FVC) than the no IS group (adjusted beta-coefficient 131.9, 95%CI 8.5-255.4, P = 0.04).


CONCLUSIONS
Treatment with an IS was independently associated with improvements in FVC in patients with both COPD and DM, compared with treatment without IS.
Department of Respiratory Medicine, Konkuk University Hospital, Seoul, Republic of Korea.
H J
HJ
Kim
J Y
JY
Lee
H S
HS
Jung
D-K
DK
Kim
S-M
SM
Lee
J-J
JJ
Yim
S-C
SC
Yang
C-G
CG
Yoo
H S
HS
Chung
Y W
YW
Kim
S K
SK
Han
Y-S
YS
Shim
C-H
CH
Lee
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003920:Diabetes Mellitus / Q000188:drug therapy*; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism / Q000494:pharmacology*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000188:drug therapy*; D012044:Regression Analysis; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D013147:Spirometry; D016896:Treatment Outcome; D014797:Vital Capacity / Q000187:drug effects
D007004:Hypoglycemic Agents; D007328:Insulin