[Effects of low concentration of chlorpyrifos prenatal exposure on generation mouse brain hippocampus and somatosensory cortex].
OBJECTIVE
To observe the effects of low concentration of organophosphate pesticide chlorpyrifos (CPF) prenatal exposure on generation mouse brain development.


METHODS
5 mg/kg CPF was administered daily on gestation days (GD) 7.5 - 11.5. On postnatal day (PD) 35, quantitative morphologic examines were measured in CA1, CA3, dentate gyrus regions of the hippocampus and somatosensory cortex.


RESULTS
After CPF prenatal exposure, selective morphology impairments were observed, showing 22.37%, 25.66% thinning of the CA1 and CA3 layers, 24.14% enlargement of the dentate guys and 81.77% to 74.61% decreasing of the ratio of neuron/glial of the somatosensory cortex.


CONCLUSIONS
There maybe slight morphological changes after prenatal low concentration pesticide exposure even without obviously systemic toxicity.
College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Xiao-ping
XP
Chen
Jian-long
JL
Jin
Chuan-wu
CW
Li
Fei-shi
FS
Wang
D000818:Animals; D004390:Chlorpyrifos / Q000633:toxicity*; D005260:Female; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013003:Somatosensory Cortex / Q000187:drug effects* / Q000473:pathology
D007306:Insecticides; D004390:Chlorpyrifos