[Correlation study on polymorphisms of vitamin D receptor gene in patients with periodontitis].
OBJECTIVE
To investigate the relationship between vitamin D receptor (VDR) gene polymorphisms and periodontitis.


METHODS
Ninety patients with aggressive periodontitis(AgP), 34 patients with chronic periodontitis and 91 healthy controls were recruited in this study. VDR gene was analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) with Taq I restriction endonuclease.


RESULTS
The detection frequency of Tt genotype was higher in the aggressive periodontitis patients than in the healthy controls (16.7% vs 7.7%, P>0.05). The difference between the female aggressive periodontitis patients and healthy controls (20.8% vs 4.2%, P<0.05) was statistically significant, but no difference was found between the male patients and controls (10.8% vs 11.6%, P>0.05). There was a strong association between aggressive periodontitis and Tt genotype in females (AgP patients vs healthy controls, OR=6.02). The detection frequency of Taq I ER-alpha genotypes was not statistically different between the chronic periodontitis patients and healthy controls.


CONCLUSIONS
In female Han Chinese population, the Tt VDR genotype may be associated with aggressive periodontitis.
Zhang
Li
L
Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing 100081, China.
Meng
Huan-xin
HX
Zhao
Hong-shan
HS
Li
Qi-yan
QY
Xu
Li
L
Chen
Zhi-bin
ZB
Shi
Dong
D
Feng
Xiang-hui
XH
D000293:Adolescent; D000328:Adult; D010520:Aggressive Periodontitis / Q000209:etiology / Q000235:genetics*; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*; D012737:Sex Factors; D055815:Young Adult
D018167:Receptors, Calcitriol