Apo(a) phenotyping and long-term prognosis for coronary artery disease.
OBJECTIVE
Identify whether the plasma concentration of Lp(a), apo(a) size or a greater affinity for fibrin predict the likelihood of cardiac death, non-fatal myocardial infarction, unstable angina, the need for additional revascularization, and stroke (MACCE).


METHODS
We analyzed the clinical prognosis of 68 patients with coronary artery disease included in a case-controlled study which evaluated Lp(a) concentration, apo(a) size, and Lp(a) fibrin-binding. Cohort was conducted over a median of 8 years. We used Kaplan-Meier survival tables to evaluate cardiovascular and cerebrovascular events in the follow-up period.


RESULTS
Apo(a) isoforms of small size are predictors of MACCE. We find an association between Lp(a) concentration and apo(a) fibrin-binding with major adverse cardiovascular and cerebrovascular events, although without statistically significant results.


CONCLUSIONS
Small-sized apo(a) isoforms are an independent risk factor for MACCE in patients with coronary artery disease in follow-up. Lp(a) plasma concentration and apo(a) fibrin-binding were associated, although not significant.
Instituto Nacional de Cardiología "Ignacio Chávez", Departamentos de Biología Molecular, Mexico, D.F.
M A
MA
Baños-González
M A
MA
Peña-Duque
E
E
Anglés-Cano
M A
MA
Martinez-Rios
A
A
Bahena
B
B
Valente-Acosta
G
G
Cardoso-Saldaña
J
J
Angulo-Ortíz
A
A
de la Peña-Díaz
D000328:Adult; D000789:Angina, Unstable / Q000097:blood; D001054:Apolipoproteins A / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005337:Fibrin / Q000378:metabolism; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood; D009204:Myocardial Revascularization; D010641:Phenotype; D011379:Prognosis; D011485:Protein Binding; D020521:Stroke / Q000097:blood
D001054:Apolipoproteins A; D017270:Lipoprotein(a); D005337:Fibrin