Interleukin-2 tickles T cell memory.
The differentiation of peripheral T lymphocytes depends on interactions between intrinsic and extrinsic factors. In this issue of Immunity, Pipkin et al. (2010) and Kalia et al. (2010) link differential interleukin-2 signaling and inflammation with the transcriptional events leading to the development of effector and memory cells.
Belz
Gabrielle T
GT
Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Melbourne, Victoria 3052, Australia. belz@wehi.edu.au
Masson
Frédérick
F
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D007376:Interleukin-2 / Q000276:immunology*
D007376:Interleukin-2