Multiple genes and locus interactions in susceptibility to vitiligo.
Refining the position of loci on chromosomes 7 and 9 previously linked with generalized vitiligo or vitiligo-associated autoimmune diseases presenting in families has been performed by high-density single-nucleotide polymorphism (SNP) genotyping. Investigation of the genetic interaction among these loci (and with a previously identified susceptibility gene, NLRP1, on chromosome 17) as risk factors for vitiligo demonstrates the complex nature of this disease.
Melanogenix Group, Division of Molecular Genetics and Development, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Aaron G
AG
Smith
Richard A
RA
Sturm
D002877:Chromosomes, Human; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014820:Vitiligo / Q000453:epidemiology* / Q000235:genetics*