Understanding the role of asymmetric cell division in cancer using C. elegans.
Asymmetric cell division is an important process to generate cell diversity and maintain tissue homeostasis. Recent evidence suggests that this process may also be crucial to prevent tumor formation. In the past 30 years, the embryo of the nematode Caenorhabditis elegans has proven to be a very powerful model to study the molecular and cellular basis of asymmetric cell division. Understanding this process in Caenorhabditis elegans may thus lead to a better understanding of stem cell function and tumorigenesis in humans.
Hyenne
Vincent
V
Laboratory of Cell Division and Differentiation, Department of Pathology and Cell Biology, Institute of Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Quebec, Canada. worm.machine@gmail.com
Chartier
Nicolas T
NT
Labbé
Jean-Claude
JC
D000818:Animals; D017173:Caenorhabditis elegans; D002455:Cell Division / Q000502:physiology*; D019070:Cell Lineage; D004195:Disease Models, Animal; D009369:Neoplasms / Q000473:pathology*; D013234:Stem Cells