[Association between the regulator of G-protein signaling 2 gene 1891-1892del TC polymorphism with hypertension in Xinjiang Kazakh population].
OBJECTIVE
To investigate the association of the 1891-1892del TC polymorphism of regulator of G-protein signalling 2 (RGS2) gene with hypertension in Xinjiang Kazakh population.


METHODS
The case-control study was performed in 444 cases and 489 controls. The genotypes of the individuals in the 1891-1892del TC locus were identified by TaqMan method.


RESULTS
A significant association was observed between the1891-1892TC insertion/deletion polymorphism with hypertension in men (OR=1.698, P=0.03) and in the total population (OR=1.32, P=0.044). The mean systolic blood pressure and serum uric acid levels of the ID+DD carriers were significantly higher than that of the II carriers (adjusted, P=0.04 and P<0.01).


CONCLUSIONS
The results suggest that the D allele of the 1891-1892TC insertion/deletion locus of the RGS2 gene might be an independent risk factor for hypertension in Xinjiang Kazakhs; and the polymorphism may have some influence on serum uric acid level in this population.
Zhang
Juhong
J
Department of Hypertension, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang, 830001 P.R.China.
Li
Nanfang
N
Yan
Zhitao
Z
Guo
Yanying
Y
Zhou
Ling
L
Wang
Hongmei
H
Yang
Jin
J
Luo
Wenli
W
Chang
Jianhang
J
D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology / Q000235:genetics*; D001794:Blood Pressure; D016022:Case-Control Studies; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000208:ethnology* / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020710:RGS Proteins / Q000235:genetics*; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood
D020710:RGS Proteins; C087182:RGS2 protein, human; D014527:Uric Acid