Synchronous hepatic, mesenteric and pulmonary Epstein-Barr virus-associated smooth muscle tumors in a renal transplant recipient.
Epstein-Barr virus-associated smooth muscle tumors (EBV-SMT) are distinct lesions that occur in immunocompromised patients. EBV-SMT following solid organ transplantation are rare and generally have an indolent biological behavior. Post-transplant EBV-SMT have been reported in various anatomical locations. This report describes a synchronous and multicentric development of EBV-SMT in liver, mesentery, and lung of a 33-yr-old male patient, 10 yr after a deceased allograft renal transplantation. The hepatic and mesenteric tumors were available for study. These tumors were composed of bland looking, desmin-positive, spindle-shaped cells which showed a strong nuclear staining for EBV with in situ hybridization technique. A literature review of post solid organ transplant EBV-SMT in the liver and lung, particularly regarding their pathogenesis, synchronicity and biological behavior would be provided.
Al Hussain
T
T
Department of Pathology, Riyadh Military Hospital Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City, and King Abdullah International Research Center, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.
Haleem
A
A
Alsaad
K O
KO
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D020031:Epstein-Barr Virus Infections / Q000473:pathology* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007124:Immunoenzyme Techniques; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D007813:Laparotomy; D008113:Liver Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000821:virology; D008175:Lung Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000821:virology; D008297:Male; D008643:Mesentery / Q000473:pathology* / Q000821:virology; D009378:Neoplasms, Multiple Primary / Q000737:chemistry / Q000473:pathology* / Q000821:virology; D010534:Peritoneal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000821:virology; D018235:Smooth Muscle Tumor / Q000737:chemistry / Q000473:pathology* / Q000821:virology; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous
D014408:Biomarkers, Tumor