Captopril and S-nitrosocaptopril as potent radiosensitizers: Comparative study and underlying mechanisms.
In an effort to improve the issue of radiotherapy treatments, we tested whether S-nitrosocaptopril, a molecule combining a NO donor and an angiotensin converting enzyme inhibitor (ACE inhibitor), could temporarily improve the hemodynamic status of experimental tumors. We monitored the effect of S-nitrosocaptopril in TLT tumors using non rinvasive magnetic resonance techniques. We identified a time window during which tumor oxygenation was improved, as a result of a combined effect on tumor blood flow and oxygen consumption. Consequently, the administration of S-nitrosocaptopril contributed to the increase in efficacy of radiation therapy, an effect that was not observed with captopril alone.
Biomedical Magnetic Resonance Unit, Louvain Drug Research Institute, Université Catholique de Louvain, B-1200 Brussels, Belgium.
Bénédicte F
BF
Jordan
Julie
J
Peeterbroeck
Oussama
O
Karroum
Caroline
C
Diepart
Julie
J
Magat
Vincent
V
Grégoire
Bernard
B
Gallez
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D002216:Captopril / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000378:metabolism / Q000532:radiotherapy*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009569:Nitric Oxide; D010101:Oxygen Consumption; D011836:Radiation Tolerance / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology
D000806:Angiotensin-Converting Enzyme Inhibitors; D014665:Vasodilator Agents; C060039:S-nitrosocaptopril; D009569:Nitric Oxide; D002216:Captopril