Will imaging assist in the selection of patients with heart failure for an ICD?
Sudden cardiac death remains the leading cause of death in the U.S. A left ventricular ejection fraction (LVEF)<30% to 35% identifies a population of patients at increased risk for sudden cardiac death. Once identified, an implantable cardioverter-defibrillator (ICD) is effective in reducing the occurrence of sudden cardiac death. Yet in a substantial proportion of patients who receive an ICD based on reduced LVEF, the device never delivers therapy. Furthermore, the majority of patients who die suddenly do not qualify for ICD placement under current LVEF-based criteria in the guidelines. This review considers the potential role of cardiac imaging in improving the selection of patients most likely to benefit from an ICD. The presence of myocardial scar and/or unrevascularized myocardial ischemia provides an important substrate for the occurrence of potentially fatal ventricular arrhythmias. The presence of clinical heart failure further increases the risk of ventricular arrhythmia. The sympathetic nervous system provides an important trigger for major arrhythmic events, both through global overactivity and through regional heterogeneity of sympathetic activity. A mismatch of myocardial perfusion and innervation may pose a particularly great risk. Imaging modalities provide unique opportunities to investigate the anatomic and pathophysiologic substrates, as well as the triggering effects of cardiac sympathetic innervation. Combining imaging and electrophysiologic modalities offers promise for improved accuracy in future selection of patients with heart failure for ICD placement.
Division of Cardiovascular Diseases, University of Cincinnati College of Medicine, and E. L. Saenger Radioisotope Laboratory, University Hospital of Cincinnati, Cincinnati, Ohio 45267-0542, USA. myron.gerson@uc.edu
Myron C
MC
Gerson
Mouhamad
M
Abdallah
James N
JN
Muth
Alexandru I
AI
Costea
D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D016757:Death, Sudden, Cardiac / Q000209:etiology / Q000517:prevention & control*; D017147:Defibrillators, Implantable; D003952:Diagnostic Imaging / Q000379:methods; D004554:Electric Countershock / Q000295:instrumentation*; D006321:Heart / Q000294:innervation; D006333:Heart Failure / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D017202:Myocardial Ischemia / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012307:Risk Factors; D013564:Sympathetic Nervous System / Q000503:physiopathology; D013997:Time Factors; D016896:Treatment Outcome