Integrating human and rodent data to identify the genetic factors involved in chronic kidney disease.
The increasing numbers of patients with chronic kidney disease combined with no satisfying interventions for preventing or curing the disease emphasize the need to better understand the genes involved in the initiation and progression of complex renal diseases, their interactions with other host genes, and the environment. Linkage and association studies in human, rat, and mouse have been successful in identifying genetic loci for various disease-related phenotypes but have thus far not been very successful identifying underlying genes. The purpose of this review is to summarize the progress in human, rat, and mouse genetic studies to show the concordance between the loci among the different species. The collective utilization of human and nonhuman mammalian datasets and resources can lead to a more rapid narrowing of disease loci and the subsequent identification of candidate genes. In addition, genes identified through these methods can be further characterized and investigated for interactions using animal models, which is not possible in humans.
Department of Medicine and Kidney Disease Center, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Michael R
MR
Garrett
Marcus G
MG
Pezzolesi
Ron
R
Korstanje
D000818:Animals; D004195:Disease Models, Animal; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D051379:Mice; D051381:Rats; D051436:Renal Insufficiency, Chronic / Q000235:genetics* / Q000503:physiopathology*