Plasma leptin concentration in dogs with diabetes mellitus.
The plasma leptin concentration was evaluated in dogs with diabetes mellitus. Twenty normal and sixteen diabetic dogs were divided into nonobese and obese groups based on body condition score, respectively. The obese normal dogs had significantly higher plasma leptin concentrations than the nonobese normal dogs, whereas there was no significant difference between the nonobese and obese diabetic dogs. In addition, the plasma leptin concentration in the obese diabetic dogs was significantly lower than that in the obese normal dogs. In conclusion, the plasma leptin concentrations in the diabetic dogs were affected by factors other than adiposity.
Laboratory of Veterinary Pharmacotherapeutics, Faculty of Agriculture, Tottori University, Japan. nnishii@muses.tottori-u.ac.jp
Naohito
N
Nishii
Miho
M
Yamasaki
Masaki
M
Takasu
Tsutomu
T
Honjoh
Haruki
H
Shibata
Yoshihiko
Y
Otsuka
Satoshi
S
Takashima
Yasunori
Y
Ohba
Hitoshi
H
Kitagawa
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood / Q000662:veterinary*; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000150:complications / Q000662:veterinary; D012016:Reference Values; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D014280:Triglycerides; D002784:Cholesterol