Gastric bypass and glucose metabolism.
Gastric bypass (GBP) surgery was originally developed to treat patients with severe obesity. Nevertheless, in those with type 2 diabetes, GBP also exerts a spectacular effect on glucose metabolism, leading to remission of the diabetes in many cases. In this report, the basic principles of the surgical procedure are outlined together with a summary of the potential mechanisms that might explain the remarkable effects of this type of operation on glucose metabolism.
Caiazzo
R
R
Univ Lille Nord, Lille, France.
Zerrweck
C
C
Verhaeghe
R
R
Hubert
T
T
Arnalsteen
L
L
Pattou
F
F
D001786:Blood Glucose / Q000378:metabolism*; D031204:Caloric Restriction; D050260:Carbohydrate Metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000601:surgery; D004040:Dietary Carbohydrates / Q000378:metabolism*; D015390:Gastric Bypass; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D009767:Obesity, Morbid / Q000378:metabolism* / Q000503:physiopathology / Q000601:surgery*
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007328:Insulin