Chemzymes: a new class of structurally rigid tricyclic amphibian organocatalyst inspired by natural product.
A new class of structurally rigid tricyclic amphibian chiral catalyst was rationally designed based on the hexahydropyrrolo[2,3-b]indole skeleton as a new type of chemzyme. This new type of chemzyme possesses a structurally rigid tricyclic skeleton and a chiral pocket which provides a well-organized chiral environment for asymmetric induction, as well as a hydrophobic pocket to enable organocatalytic reactions to proceed smoothly both in organic solvents and in water.
Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371.
Jian
J
Xiao
Feng-Xia
FX
Xu
Yun-Peng
YP
Lu
Teck-Peng
TP
Loh
D000663:Amphibians; D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D015195:Drug Design; D004798:Enzymes; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
D001688:Biological Products; D004798:Enzymes; D007211:Indoles; D011758:Pyrroles; C511200:hexahydropyrrolo(2,3-b)indole