CD4+ T cell plasticity-Th2 cells join the crowd.
In this issue of Immunity, Hegazy et al. (2010) report that in response to lymphocytic choriomeningitis virus (LCMV) infection, fully differentiated virus-specific Th2 cells can be reprogrammed into GATA-3(+)T-bet(+) cells capable of producing both interleukin-4 and interferon-gamma.
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. jfzhu@niaid.nih.gov
Jinfang
J
Zhu
William E
WE
Paul
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D018418:Th2 Cells / Q000166:cytology / Q000276:immunology*