[Adaptive response comparison of CBA mice splenocyte and Drosophila melanogaster larva neuroblast, developed in conditions of chronic gamma-irradiation influence with low-dose rate].
The level of DNA damage and apoptosis of mice splenocytes, developed in condition of chronic gamma-irradiation with low-doze rate (8 +/- 2 cGy), in response to high-dose irradiation (2 Gy) in the completion of irradiation, as well in 30 minutes after irradiation was analysed. Reaction of neuroblasts of Drosophila melanogaster larvae (4 cGy - priming dose, 3 and 6 Gy--challenging doses) is also investigated. The adaptive response by the level of DNA-damage is shown for both objects. This resistance is presumably connected to increase of DNA-damage repair efficiency in preirradiated objects, as well promotion of sensitivity to apoptosis (in the case of Drosophila larvae neuroblast). It is assumed, that observed changes may be result of selection of cell during development in condition of an chronic irradiation.
Velegzhaninov
I O
IO
Mezentseva
V N
VN
Moskalev
A A
AA
D000222:Adaptation, Physiological / Q000528:radiation effects*; D000818:Animals; D017209:Apoptosis / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004331:Drosophila melanogaster / Q000235:genetics / Q000528:radiation effects*; D005260:Female; D005720:Gamma Rays; D017952:Ganglia, Invertebrate / Q000528:radiation effects; D007814:Larva / Q000528:radiation effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000528:radiation effects*