Occupational exposure to terbufos and the incidence of cancer in the Agricultural Health Study.
OBJECTIVE
Terbufos is the fourth most commonly used organophosphate insecticide (OP) in the United States. Terbufos has not been demonstrated to be carcinogenic in rodents, although non-arsenical insecticides, including OPs, have been associated with excess cancer in epidemiologic studies. We investigated associations between use of terbufos and the incidence of cancer.


METHODS
The Agricultural Health Study is a prospective cohort study of 57,310 licensed pesticide applicators from Iowa and North Carolina. Detailed information about 50 pesticides, including terbufos, and potential confounders was obtained from self-administered questionnaires. Terbufos intensity-weighted lifetime exposure-days were defined as (lifetime exposure-days) x (exposure intensity score). Cases include all first primary cancers diagnosed between enrollment and December 31, 2005. Hazard ratios (HR) and 95% CI were calculated with Cox proportional hazards models, adjusting for potential confounders.


RESULTS
Overall cancer risk was slightly increased among terbufos users [HR 1.21 (1.06-1.37)]. Suggestive associations were observed between terbufos use and cancers of the prostate (HR(highest tertile) = 1.21; 95% CI = 0.99-1.47) and lung (HR(middle tertile) = 1.45; 95% CI = 0.95-2.22) and leukemia (HR(middle tertile) = 2.38; 95% CI = 1.35-4.21) and non-Hodgkin's lymphoma (HR(middle tertile) = 1.94; 95% CI = 1.16-3.22), although the exposure-response gradients were non-monotonic and p for trends were not significant.


CONCLUSIONS
We found suggestive associations between occupational terbufos use and several cancer sites. However, cautious interpretation of these results is warranted by the lack of existing experimental and epidemiologic evidence to support carcinogenic effects of terbufos.
Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, 270 Farber Hall, Buffalo, NY, USA. mrbonner@buffalo.edu
Matthew R
MR
Bonner
Brent A
BA
Williams
Jennifer A
JA
Rusiecki
Aaron
A
Blair
Laura E
LE
Beane Freeman
Jane A
JA
Hoppin
Mustafa
M
Dosemeci
Jay
J
Lubin
Dale P
DP
Sandler
Michael C R
MC
Alavanja
D000383:Agriculture; D002273:Carcinogens; D003625:Data Collection; D006801:Humans; D015994:Incidence; D007306:Insecticides; D007484:Iowa / Q000453:epidemiology; D007938:Leukemia / Q000150:complications / Q000453:epidemiology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000453:epidemiology; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000453:epidemiology*; D009423:Nervous System Neoplasms / Q000150:complications / Q000453:epidemiology; D009657:North Carolina / Q000453:epidemiology; D016273:Occupational Exposure / Q000706:statistics & numerical data*; D009943:Organophosphorus Compounds; D009946:Organothiophosphorus Compounds; D010361:Patients; D010575:Pesticides; D011795:Surveys and Questionnaires
D002273:Carcinogens; D007306:Insecticides; D009943:Organophosphorus Compounds; D009946:Organothiophosphorus Compounds; D010575:Pesticides; C012568:terbufos