[Peculiarities of dynamics and prognostic value of NT-proBNP level in different variants of treatment of patients with acute coronary syndrome].
Aim of the study was to assess dynamics of NT proBNP in ACS as well as to analyze effect of different methods of treatment on the level of the parameter and its prognostic value.


METHODS
Patients aged 30-70 years were included into the study: 52 patients with ST segment elevation ACS (STEACS), 61 patients with non ST-segment elevation ACS (NSTEACS). Control group comprised 20 people of the same age without ischemic heart disease. In all patients serum was taken for subsequent measurement of NT proBNP at admission, on day 3 of hospitalization, and before discharge (days 7-10).


RESULTS
In ACS baseline NT proBNP concentration was significantly higher than in stable angina and in control group. During period of hospitalization NT proBNP level rose in the group of patients with STEACS and fell in the group of patients with NSTEACS. After early restoration of coronary blood flow (less than 4 hours after onset on the pain syndrome) in patients with STEACS dysfunction of the left ventricular myocardium was less pronounced (NT proBNP level was lower). High level of NT proBNP was an unfavorable prognostic factor in ACS irrespective of the selected tactics of treatment.
E V
EV
Shreĭder
R M
RM
Shakhnovich
E G
EG
Bosykh
M Ia
MIa
Ruda
D054058:Acute Coronary Syndrome / Q000097:blood / Q000175:diagnosis / Q000628:therapy*; D000328:Adult; D000368:Aged; D003326:Coronary Circulation; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011379:Prognosis; D011498:Protein Precursors; D013997:Time Factors
D010446:Peptide Fragments; D011498:Protein Precursors; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain