[Chromosome karyotype and Y chromosome microdeletion analysis in 133 idiopathic male infertile patients].
OBJECTIVE
To explore the relationship between chromosomal abnormalities and Y chromosome microdeletions in idiopathic male infertile patients.


METHODS
Karyotypic analysis and PCR were carried out in 133 male idiopathic infertile patients for chromosome karyotype and Y chromosome microdeletion analysis.


RESULTS
Of the 133 patients, 25 (18.80%) were found to have chromosome abnormalities, and 12 (9.02%) were found to have Y chromosome microdeletions including 2 with varicocele and 2 with cryptorchism. Four patients had both chromosomal abnormalities and Y chromosome microdeletions.


CONCLUSIONS
The chromosomal abnormalities and Y chromosome microdeletions may play an important role in idiopathic male infertility, suggesting the importance of examinations of chromosomal abnormalities and Y chromosome microdeletions in such patients.
Department of Obstetrics and Gynecology, Huizhou Municipal Central Hospital, Huizhou 516000, China. jiyanqurong163@com
Yan
Y
Ji
Hong-jia
HJ
Xu
Jian-chu
JC
Huang
D000328:Adult; D002872:Chromosome Deletion; D041322:Chromosomes, Human, Y / Q000235:genetics; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D007621:Karyotyping; D008297:Male; D012729:Sex Chromosome Aberrations; D058533:Sex Chromosome Disorders of Sex Development / Q000235:genetics; D055815:Young Adult