P66Shc signals to age.
Oxygen metabolism is thought to impact on aging through the formation of reactive oxygen species (ROS) that are supposed to damage biological molecules. The study of p66(Shc), a crucial regulator of ROS level involved in aging dysfunction, suggests that the incidence of degenerative disease and longevity are determined by a specific signaling function of ROS other than their unspecific damaging property.
Trinei
Mirella
M
Congenia Srl, 20139 Milan, Italy.
Berniakovich
Ina
I
Beltrami
Elena
E
Migliaccio
Enrica
E
Fassina
Ambrogio
A
Pelicci
PierGiuseppe
P
Giorgio
Marco
M
D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008136:Longevity / Q000235:genetics* / Q000502:physiology; D009154:Mutation; D010100:Oxygen / Q000378:metabolism; D020033:Protein Isoforms; D055765:Shc Signaling Adaptor Proteins / Q000378:metabolism*; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1
D020033:Protein Isoforms; C528024:SHC1 protein, human; D055765:Shc Signaling Adaptor Proteins; D000071425:Src Homology 2 Domain-Containing, Transforming Protein 1; D010100:Oxygen