MD-logic artificial pancreas system: a pilot study in adults with type 1 diabetes.
OBJECTIVE
Current state-of-the-art artificial pancreas systems are either based on traditional linear control theory or rely on mathematical models of glucose-insulin dynamics. Blood glucose control using these methods is limited due to the complexity of the biological system. The aim of this study was to describe the principles and clinical performance of the novel MD-Logic Artificial Pancreas (MDLAP) System.


METHODS
The MDLAP applies fuzzy logic theory to imitate lines of reasoning of diabetes caregivers. It uses a combination of control-to-range and control-to-target strategies to automatically regulate individual glucose levels. Feasibility clinical studies were conducted in seven adults with type 1 diabetes (aged 19-30 years, mean diabetes duration 10 +/- 4 years, mean A1C 6.6 +/- 0.7%). All underwent 14 full, closed-loop control sessions of 8 h (fasting and meal challenge conditions) and 24 h.


RESULTS
The mean peak postprandial (overall sessions) glucose level was 224 +/- 22 mg/dl. Postprandial glucose levels returned to <180 mg/dl within 2.6 +/- 0.6 h and remained stable in the normal range for at least 1 h. During 24-h closed-loop control, 73% of the sensor values ranged between 70 and 180 mg/dl, 27% were >180 mg/dl, and none were <70 mg/dl. There were no events of symptomatic hypoglycemia during any of the trials.


CONCLUSIONS
The MDLAP system is a promising tool for individualized glucose control in patients with type 1 diabetes. It is designed to minimize high glucose peaks while preventing hypoglycemia. Further studies are planned in the broad population under daily-life conditions.
The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, The National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Eran
E
Atlas
Revital
R
Nimri
Shahar
S
Miller
Eli A
EA
Grunberg
Moshe
M
Phillip
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism / Q000628:therapy*; D004435:Eating; D005215:Fasting; D005240:Feasibility Studies; D005260:Female; D017143:Fuzzy Logic; D006801:Humans; D008297:Male; D008954:Models, Biological; D019397:Pancreas, Artificial; D010865:Pilot Projects; D011474:Prosthesis Design; D016896:Treatment Outcome; D055815:Young Adult
D001786:Blood Glucose