Circulating maternal testosterone concentrations at 18 weeks of gestation predict circulating levels of antimüllerian hormone in adolescence: a prospective cohort study.
This prospective study was established to determine the impact of maternal circulating androgen levels during normal pregnancy on ovarian function, as determined by early follicular phase antimüllerian hormone (AMH) levels, inhibin B levels, and antral follicle count (AFC) in 244 female offspring in adolescence. Maternal circulating total testosterone levels at 18 weeks' gestation were statistically significantly correlated with early follicular-phase circulating AMH levels in female adolescent offspring, but no other statistically significant correlations were determined among the maternal androgens at 18 or 34 weeks of gestation and the markers of adolescent ovarian function.
Hart
Roger
R
School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia. Electronic address: roger.hart@uwa.edu.au.
Sloboda
Deborah M
DM
Liggins Institute, University of Auckland, and the National Research Centre for Growth and Development, Auckland, New Zealand.
Doherty
Dorota A
DA
School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia; Women and Infants Research Foundation, King Edward Memorial Hospital, Perth, Western Australia, Australia.
Norman
Robert J
RJ
Research Centre for Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia, Australia.
Atkinson
Helen C
HC
School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia.
Newnham
John P
JP
School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia; Women and Infants Research Foundation, King Edward Memorial Hospital, Perth, Western Australia, Australia.
Dickinson
Jan E
JE
School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia.
Hickey
Martha
M
School of Women's and Infants' Health, University of Western Australia, Perth, Western Australia, Australia.
D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015331:Cohort Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D008431:Maternal-Fetal Exchange / Q000502:physiology; D009035:Mothers; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000097:blood*; D011297:Prenatal Exposure Delayed Effects / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D013739:Testosterone / Q000097:blood*
D013739:Testosterone; D054304:Anti-Mullerian Hormone