Polymorphism in the GALNT1 gene and epithelial ovarian cancer in non-Hispanic white women: the Ovarian Cancer Association Consortium.
Aberrant glycosylation is a well-described hallmark of cancer. In a previous ovarian cancer case control study that examined polymorphisms in 26 glycosylation-associated genes, we found strong statistical evidence (P = 0.00017) that women who inherited two copies of a single-nucleotide polymorphism in the UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase, GALNT1, had decreased ovarian cancer risk. The current study attempted to replicate this observation. The GALNT1 single-nucleotide polymorphism rs17647532 was genotyped in 6,965 cases and 8,377 controls from 14 studies forming the Ovarian Cancer Association Consortium. The fixed effects estimate per rs17647532 allele was null (odds ratio, 0.99; 95% confidence interval, 0.92-1.07). When a recessive model was fit, the results were unchanged. Test for heterogeneity of the odds ratios revealed consistency across the 14 replication sites but significant differences compared with the original study population (P = 0.03). This study underscores the need for replication of putative findings in genetic association studies.
Department of Epidemiology and Genetics, Division of Cancer Prevention and Control, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA. Catherine.Phelan@moffitt.org
Catherine M
CM
Phelan
Ya-Yu
YY
Tsai
Ellen L
EL
Goode
Robert A
RA
Vierkant
Brooke L
BL
Fridley
Jonathan
J
Beesley
Xiao Qing
XQ
Chen
Penelope M
PM
Webb
Stephen
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Chanock
Daniel W
DW
Cramer
Kirsten
K
Moysich
Robert P
RP
Edwards
Jenny
J
Chang-Claude
Montserrat
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Garcia-Closas
Hannah
H
Yang
Shan
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Wang-Gohrke
Rebecca
R
Hein
Adele C
AC
Green
Jolanta
J
Lissowska
Michael E
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Carney
Galina
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Lurie
Lynne R
LR
Wilkens
Roberta B
RB
Ness
Celeste Leigh
CL
Pearce
Anna H
AH
Wu
David J
DJ
Van Den Berg
Daniel O
DO
Stram
Kathryn L
KL
Terry
David C
DC
Whiteman
Alice S
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Whittemore
Richard A
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DiCioccio
Valerie
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McGuire
Jennifer A
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Doherty
Mary Anne
MA
Rossing
Hoda
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Anton-Culver
Argyrios
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Ziogas
Claus
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Hogdall
Estrid
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Hogdall
Susanne
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Krüger Kjaer
Jan
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Blaakaer
Lydia
L
Quaye
Susan J
SJ
Ramus
Ian
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Jacobs
Honglin
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Song
Paul D P
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Pharoah
Edwin S
ES
Iversen
Jeffrey R
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Marks
Malcolm C
MC
Pike
Simon A
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Gayther
Julie M
JM
Cunningham
Marc T
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Goodman
Joellen M
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Schildkraut
Georgia
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Chenevix-Trench
Andrew
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Berchuck
Thomas A
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Sellers
D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D017350:N-Acetylgalactosaminyltransferases / Q000235:genetics*; D009375:Neoplasms, Glandular and Epithelial / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044465:White People; D000097763:Polypeptide N-acetylgalactosaminyltransferase
D017350:N-Acetylgalactosaminyltransferases; D000097763:Polypeptide N-acetylgalactosaminyltransferase