Kalzium ist nicht alles.
Elevation of cerebral Mg2+ with a novel orally delivered ionophore, magnesium threonate, enhances cognition in young and old rats over a 12-24 day treatment interval, as outlined in a paper by Slutsky et al. in this issue of Neuron. Despite both Mg2+ and Zn2+ blocking the NMDA receptor channel, sustained extracellular Mg2+ elevation mimics sustained synaptic Zn2+ concentrations by increasing hippocampal NR2B expression and bouton density.
Mental Health Research Institute, 155 Oak Street, Parkville, Victoria 3052, Australia. abush@mhri.edu.au
Ashley I
AI
Bush
D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D002413:Cations, Divalent / Q000378:metabolism; D003071:Cognition / Q000502:physiology; D006801:Humans; D008274:Magnesium / Q000378:metabolism / Q000502:physiology*; D008568:Memory / Q000502:physiology; D015032:Zinc / Q000378:metabolism / Q000502:physiology
D002413:Cations, Divalent; D008274:Magnesium; D015032:Zinc; D002118:Calcium