Albumin production activity of primary rat hepatocytes is improved on type V collagen.
Primary rat hepatocytes were cultured on type V collagen. Hepatocyte spreading on type V collagen was inferior compared with that on type I collagen. However, the albumin production rates of hepatocytes cultured on type V collagen were approximately twice as high as those of hepatocytes cultured on type I collagen.
Ijima
Hiroyuki
H
Department of Chemical Engineering, Faculty of Engineering, Graduate School, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, Japan. ijima@chem-eng.kyushu-u.ac.jp
Ogata
Ryohei
R
Murasawa
Yusuke
Y
Wang
Pi-Chao
PC
D000418:Albumins / Q000096:biosynthesis*; D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods; D002478:Cells, Cultured; D024042:Collagen Type I / Q000494:pharmacology; D024062:Collagen Type V / Q000494:pharmacology*; D004797:Enzyme-Linked Immunosorbent Assay; D022781:Hepatocytes / Q000187:drug effects* / Q000378:metabolism*; D051381:Rats
D000418:Albumins; D024042:Collagen Type I; D024062:Collagen Type V