Medial prefrontal cortex hyperactivation during social exclusion in borderline personality disorder.
Frontal systems dysfunction and abandonment fears represent central features of borderline personality disorder (BPD). BPD subjects (n=10) and matched non-psychiatric comparison subjects (n=10) completed a social-cognitive task with two confederates instructed to either include or exclude subjects from a circumscribed interaction. Evoked cerebral blood oxygenation in frontal cortex was measured using 16-channel functional near infrared spectroscopy. BPD subjects showed left medial prefrontal cortex hyperactivation during social exclusion suggesting potential dysfunction of frontolimbic circuitry.
Department of Psychology, Drexel University, Philadelphia, PA, United States. anthony.ruocco@gmail.com
Anthony C
AC
Ruocco
John D
JD
Medaglia
Jennifer R
JR
Tinker
Hasan
H
Ayaz
Evan M
EM
Forman
Cory F
CF
Newman
J Michael
JM
Williams
Frank G
FG
Hillary
Steven M
SM
Platek
Banu
B
Onaral
Douglas L
DL
Chute
D000293:Adolescent; D000328:Adult; D001883:Borderline Personality Disorder / Q000473:pathology* / Q000523:psychology*; D001931:Brain Mapping; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017397:Prefrontal Cortex / Q000473:pathology*; D012934:Social Isolation / Q000523:psychology*; D013055:Spectrophotometry, Infrared / Q000379:methods; D055815:Young Adult
D006454:Hemoglobins