Metal(II)-ligand molar ratio dependence of enantioseparation of tartaric acid by ligand exchange CE with Cu(II) and Ni(II)-D-quinic acid systems.
Enantioseparation of tartaric acid by ligand exchange CE with a Cu(II)-D-quinic acid system was studied. Racemic tartaric acid was enantioseparated by ligand exchange CE using BGEs containing relatively low Cu(II)-D-quinic acid molar ratios ranging from 1:1 to 1:3 and high molar ratios ranging from 1:8 to 1:12 but was not enantioseparated using BGEs with medium molar ratios ranging from 1:4 to 1:6. While the migration order of D-tartaric acid was prior to L-tartaric acid at the lower Cu(II)-D-quinic acid molar ratios, the enantiomer migration order was reversed at the higher molar ratios. These results were compared with those for Ni(II)-D-quinic acid system. The molar ratio dependence of enantiomer migration order can be attributed to a change in the coordination structure of Cu(II) ion with D-quinic acid.
Toyama Institute of Health, Nakataikoyama, Toyama, Japan. shuji.kodama@pref.toyama.lg.jp
Shuji
S
Kodama
Sen-ichi
S
Aizawa
Atsushi
A
Taga
Tomohisa
T
Yamashita
Tomoko
T
Kemmei
Kentaro
K
Suzuki
Yoshitaka
Y
Honda
Atsushi
A
Yamamoto
D003300:Copper / Q000737:chemistry; D019075:Electrophoresis, Capillary / Q000379:methods*; D008024:Ligands; D008670:Metals / Q000737:chemistry; D009532:Nickel / Q000737:chemistry; D011801:Quinic Acid / Q000737:chemistry*; D013237:Stereoisomerism; D013644:Tartrates / Q000302:isolation & purification*
D008024:Ligands; D008670:Metals; D013644:Tartrates; D011801:Quinic Acid; D003300:Copper; D009532:Nickel; C029768:tartaric acid