Strawberry consumption is associated with increased antioxidant capacity in serum.
Strawberries are known to contain antioxidants, but the significance of ingesting antioxidant-rich fruits remains to be established. In order to determine whether the consumption of strawberries impacted measures of in vivo antioxidant capacity, frozen strawberries (250 g) were administered daily for 3 weeks to 21 healthy female volunteers. Compliance was confirmed by quantitating pelargonidin-glucuronide, urolithin A-glucuronide, and 2,5-dimethyl-4-hydroxy-3-[(2)H]furanone-glucuronide in plasma and urine by liquid chromatography-mass spectrometry and antioxidant capacity in serum measured by the increase in lag phase of low-density lipoprotein after copper sulfate exposure, DNA strand breaks in lymphocytes, and activity of phase II enzymes. Among these measures lipid peroxidation lag time increased by 20% (P < .01), whereas other measures did not change significantly. The potent antioxidant defenses in humans make determination of changes due to dietary ingestion in healthy individuals difficult. In summary, daily consumption of strawberries resulted in a modest but significant increase in antioxidant capacity in a healthy population.
Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA. shenning@mednet.ucla.edu
Susanne M
SM
Henning
Navindra P
NP
Seeram
Yanjun
Y
Zhang
Luyi
L
Li
Kun
K
Gao
Ru-Po
RP
Lee
David C
DC
Wang
Alona
A
Zerlin
Hannah
H
Karp
Gail
G
Thames
Jenny
J
Kotlerman
Zhaoping
Z
Li
David
D
Heber
D000328:Adult; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology*; D008078:Cholesterol, LDL / Q000378:metabolism; D004032:Diet; D005260:Female; D031985:Fragaria; D005638:Fruit; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D010349:Patient Compliance; D028321:Plant Preparations / Q000494:pharmacology*; D013997:Time Factors; D055815:Young Adult
D000975:Antioxidants; D008078:Cholesterol, LDL; D028321:Plant Preparations