So similar, yet so different: uncovering distinctive features in the genomes of Salmonella enterica serovars Typhimurium and Typhi.
Salmonella enterica represents a major human and animal pathogen. Many S. enterica genomes have been completed and many more genome sequencing projects are underway, constituting an excellent resource for comparative genome analysis studies leading to a better understanding of bacterial evolution and pathogenesis. Salmonella enterica serovar Typhimurium and Typhi are the best-characterized serovars, with the first being involved in localized gastroenteritis in many hosts and the latter causing a systemic human-specific disease. Here, we summarize the major genetic differences between the two different serovars. We detail the divergent repertoires of the virulence factors responsible for the pathogenesis of the organisms and that ultimately result in the distinct clinical outcomes of infection. This comparative genomic overview highlights hypotheses for future investigations on S. enterica pathogenesis and the basis of host specificity.
Department of Microbiology and Immunology, University of Montreal, Montréal, QC, Canada.
Sébastien C
SC
Sabbagh
Chantal G
CG
Forest
Christine
C
Lepage
Jean-Mathieu
JM
Leclerc
France
F
Daigle
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics; D019143:Evolution, Molecular; D016680:Genome, Bacterial; D006801:Humans; D012485:Salmonella typhi / Q000235:genetics* / Q000472:pathogenicity; D012486:Salmonella typhimurium / Q000235:genetics* / Q000472:pathogenicity; D013045:Species Specificity; D037521:Virulence Factors / Q000235:genetics
D001426:Bacterial Proteins; D037521:Virulence Factors