[Outcome differences in pediatric patients with type 1 diabetes mellitus depending on their HLA-DQ genotypes].
OBJECTIVE
Our hypothesis is that there is a relationship between the short term outcomes of pediatric patients with type I diabetes mellitus and their HLA-DQ genotypes.


METHODS
We performed a descriptive epidemiologic study of 129 children and adolescents under 16 years old with type 1 diabetes mellitus. We studied their HLA DQ genotypes and classified them into groups of diabetogenic risk. We studied general clinic and analytic parameters at onset of the disease and during a period of 3 years, and the development of associated chronic complications.


RESULTS
In total, 93.8% of our patients had diabetes-risk HLA-DQ genotypes. Onset of the disease occurred earlier in patients who belonged to risk group III, and they had less pancreatic reserve. During the follow-up period, significant differences in systolic and diastolic blood pressure were found in patients in risk group III, and in diastolic blood pressure in patients in risk group I.


CONCLUSIONS
Patients in risk group III have an onset at a lower age and present significant differences in systolic and diastolic blood pressure during the follow up period.
García Cabezas
Miguel Angel
MA
Servicio de Pediatría, Hospital General, Ciudad Real, España. partisanocabezas@gmail.com
Giralt Muiña
Patricio
P
Fernández Valle
Bárbara
B
Benito López
Pedro
P
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006683:HLA-DQ Antigens / Q000235:genetics*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016896:Treatment Outcome
D006683:HLA-DQ Antigens