The resurgence of acyclic nucleic acids.
This review examines acyclic nucleoside analogs as therapeutic agents, potential progenitor candidates to RNA, and novel building blocks for nucleic-acid nanotechnology. Together, these areas of research provide new insights into the structural and functional properties of nucleic acids and suggest new paradigms for nucleic acid self-assembly.
Zhang
Su
S
Center for Evolutionary Functional Genomics, The Biodesign Institute, and Department of Chemistry and Biochemistry at Arizona State University, Tempe, Arizona 85287-5301, USA.
Switzer
Christopher
C
Chaput
John C
JC
D036103:Nanotechnology; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000187:drug effects; D009705:Nucleosides / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use
D009696:Nucleic Acids; D009705:Nucleosides