In search of pure liquid salt forms of aspirin: ionic liquid approaches with acetylsalicylic acid and salicylic acid.
We present an ionic liquid (IL) approach towards a dual functional liquid salt form of aspirin using different pharmaceutically active cations composed of antibacterials, analgesics, local anesthetics, and antiarrhythmic drugs in combination with acetylsalicylic acid or its metabolite salicylic acid and discuss stability of these ILs in comparison to solid salts. Several low-melting or liquid salts of salicylic acid with dual functionality and promising properties were isolated and characterized; however, although such ILs with aspirin could be prepared, they suffer from limited stability and slowly decompose into the corresponding salicylate ILs when exposed to moisture.
Bica
Katharina
K
The Queen's University of Belfast, QUILL, School of Chemistry and Chemical Engineering, Belfast, Northern Ireland BT9 5AG.
Rijksen
Christiaan
C
Nieuwenhuyzen
Mark
M
Rogers
Robin D
RD
D001241:Aspirin / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D006868:Hydrolysis; D052578:Ionic Liquids / Q000737:chemistry*; D044367:Phase Transition; D020156:Salicylic Acid / Q000737:chemistry*; D012492:Salts / Q000737:chemistry*; D044366:Transition Temperature
D052578:Ionic Liquids; D012492:Salts; D020156:Salicylic Acid; D001241:Aspirin