The genetics of major depression: moving beyond the monoamine hypothesis.
Efforts to unlock the biology of major depressive disorder (MDD) are proceeding on multiple fronts. In this article, the authors review the current understanding of epidemiological evidence for a heritable component to MDD risk, as well as recent advances in linkage, candidate gene, and genome-wide association analyses of MDD and related disease subtypes and endophenotypes. While monoamine signaling has preoccupied the bulk of scientific investigation to date, nontraditional gene candidates such as PCLO and GRM7 are now emerging and beginning to change the landscape for future human and animal research on depression.
Shyn
Stanley I
SI
Department of Psychiatry, Langley Porter Psychiatric Institute, University of California, San Francisco, San Francisco, CA 94143-0984, USA.
Hamilton
Steven P
SP
D003865:Major Depressive Disorder / Q000201:enzymology* / Q000235:genetics* / Q000503:physiopathology; D015870:Gene Expression / Q000235:genetics; D008040:Genetic Linkage; D055106:Genome-Wide Association Study; D006801:Humans; D008995:Monoamine Oxidase / Q000378:metabolism*; D010641:Phenotype
D008995:Monoamine Oxidase