Organogenesis and development of the liver.
Embryonic development of the liver has been studied intensely, yielding insights that impact diverse areas of developmental and cell biology. Understanding the fundamental mechanisms that control hepatogenesis has also laid the basis for the rational differentiation of stem cells into cells that display many hepatic functions. Here, we review the basic molecular mechanisms that control the formation of the liver as an organ.
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Karim
K
Si-Tayeb
Frédéric P
FP
Lemaigre
Stephen A
SA
Duncan
D000818:Animals; D001659:Biliary Tract / Q000196:embryology / Q000378:metabolism; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism; D006410:Hematopoiesis; D055166:Hepatic Stellate Cells / Q000166:cytology / Q000378:metabolism; D022781:Hepatocytes / Q000166:cytology / Q000378:metabolism; D006801:Humans; D007728:Kupffer Cells / Q000166:cytology / Q000378:metabolism; D008099:Liver / Q000098:blood supply / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D051379:Mice; D015398:Signal Transduction; D014158:Transcription, Genetic