[Immune mechanisms of comorbidity of HIV infection and pulmonary tuberculosis].
OBJECTIVE
to study the immune system in patients with tuberculosis-associated HIV infection at different stages of disease and during antiretroviral therapy (ARVT).


METHODS
The study included 90 patients with tuberculosis-associated HIV infection; a control group comprised 117 HIV-infected patients. The total number of T lymphocytes and their subpopulations (CD3+, CD4+, and CD8+) and the levels of the cytokines TNF-alpha, IL-6, and their soluble receptors SRp55 of TNF-alpha (type I), SRp75 of TNF-alpha (type II), and SR of IL-6 in the serum.


RESULTS
T-cell immunodeficiency was detected at all stages of HIV infection accompanied by CD3+ and CD4+ cell deficiency and decreased immunoregulatory index. The cytokine profile changes were indicative of a more noticeable reduction in the functional activity of T helper cells type I in patients with HIV-associated tuberculosis.


CONCLUSIONS
The efficiency of ARVT in patients with HIV-associated tuberculosis was confirmed by a lower viral load and higher CD4+ cells. Heterodirectional changes in the content of cytokines and their receptors characterized by a considerable increase in the levels of TNF-alpha, IL-6, SR of TNF-alpha and a drastic reduction in the level of SR of IL-6 may be considered as a marker of immune recovery.
S A
SA
Sotnichenko
E V
EV
Markelova
L F
LF
Skliar
B I
BI
Gel'tser
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology*; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D015415:Biomarkers; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D015897:Comorbidity; D016207:Cytokines / Q000378:metabolism; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000276:immunology*; D019562:Viral Load; D055815:Young Adult
D019380:Anti-HIV Agents; D015415:Biomarkers; D016207:Cytokines