[PPARgamma and cancer].
Peroxisome proliferator-activated receptor gamma (PPARgamma) is known to regulate cell growth and differentiation of adipocytes and a variety of tissues, and has been demonstrated to be up regulated in many cancer tissues, including colon and breast cancers. I here summarize the role of PPARgamma signaling evoked by PPARgamma agonists and antagonists in cancer development, and discuss the potential application of PPARgamma ligands for cancer chemoprevention. A growth suppressive effect of PPARgamma agonist is well exemplified in a chemically-induced colon cancer model in mice. It is interesting to note that inhibition of PPARgamma signaling also shows suppressive effects on cell invasion and metastasis in both in vitro and in vivo settings. A more detailed analysis is warranted to dissect the molecular basis for the tumor suppressive function of PPARgamma.
National Cancer Center Research Institute.
Hitoshi
H
Nakagama
D000818:Animals; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D047495:PPAR gamma / Q000819:agonists / Q000037:antagonists & inhibitors / Q000502:physiology*
D047495:PPAR gamma