Pharmacological evidence that both cognitive memory and habit formation contribute to within-session learning of concurrent visual discriminations.
The monkey's ability to learn a set of visual discriminations presented concurrently just once a day on successive days (24-h ITI task) is based on habit formation, which is known to rely on a visuo-striatal circuit and to be independent of visuo-rhinal circuits that support one-trial memory. Consistent with this dissociation, we recently reported that performance on the 24-h ITI task is impaired by a striatal-function blocking agent, the dopaminergic antagonist haloperidol, and not by a rhinal-function blocking agent, the muscarinic cholinergic antagonist scopolamine. In the present study, monkeys were trained on a short-ITI form of concurrent visual discrimination learning, one in which a set of stimulus pairs is repeated not only across daily sessions but also several times within each session (in this case, at about 4-min ITIs). Asymptotic discrimination learning rates in the non-drug condition were reduced by half, from approximately 11 trials/pair on the 24-h ITI task to approximately 5 trials/pair on the 4-min ITI task, and this faster learning was impaired by systemic injections of either haloperidol or scopolamine. The results suggest that in the version of concurrent discrimination learning used here, the short ITIs within a session recruit both visuo-rhinal and visuo-striatal circuits, and that the final performance level is driven by both cognitive memory and habit formation working in concert.
Turchi
Janita
J
Laboratory of Neuropsychology, National Institute of Mental Health, Bethesda, MD 20892, USA. turchij@mail.nih.gov
Devan
Bryan
B
Yin
Pingbo
P
Sigrist
Emmalynn
E
Mishkin
Mortimer
M
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology*; D004192:Discrimination, Psychological / Q000187:drug effects / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004334:Drug Administration Schedule; D005260:Female; D006184:Habits; D006220:Haloperidol / Q000494:pharmacology; D008253:Macaca mulatta; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D018727:Muscarinic Antagonists / Q000494:pharmacology; D010364:Pattern Recognition, Visual / Q000187:drug effects / Q000502:physiology*; D010775:Photic Stimulation / Q000379:methods; D011897:Random Allocation; D012601:Scopolamine / Q000494:pharmacology; D018709:Statistics, Nonparametric
D018492:Dopamine Antagonists; D018727:Muscarinic Antagonists; D012601:Scopolamine; D006220:Haloperidol