Review: green tea polyphenols in chemoprevention of prostate cancer: preclinical and clinical studies.
The prevention of prostate cancer (PCa) is a crucial medical challenge in developed countries. PCa remains surrounded by puzzles in spite of the considerable progress in research, diagnosis, and treatment. It is an ideal target for chemoprevention, as clinically significant PCa usually requires more than two decades for development. Green tea and its major constituent epigallocatechin gallate (EGCG) have been extensively studied as a potential treatment for a variety of diseases including cancer. In this review, we highlight the evidences of green tea polyphenols from preclinical and clinical studies in the chemoprevention/chemotherapy of PCa.
Department of Dermatology, University of Wisconsin, Madison, Wisconsin 53706, USA.
Naghma
N
Khan
Vaqar Mustafa
VM
Adhami
Hasan
H
Mukhtar
D000818:Animals; D016588:Anticarcinogenic Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use; D002392:Catechin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D018450:Disease Progression; D005419:Flavonoids / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010636:Phenols / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D059808:Polyphenols; D011471:Prostatic Neoplasms / Q000178:diet therapy / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control*; D012307:Risk Factors; D013662:Tea / Q000009:adverse effects / Q000737:chemistry*
D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate