Fulminant infectious mononucleosis and recurrent Epstein-Barr virus reactivation in an adolescent.
We describe a unique case of fulminant infectious mononucleosis and recurrent Epstein-Barr virus reactivation presenting in an adolescent. Detailed assays of Epstein-Barr virus-specific T cell immunity revealed defects in the patient's T cell receptor signalling pathway characterized by a lack of interleukin-2 and CD25 expression, which may have contributed to her clinical course. Allogeneic stem cell transplantation reversed the clinical and laboratory phenotype.
Clinical Immunohaematology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.
Jamie P
JP
Nourse
Kimberley
K
Jones
Ujjwal
U
Dua
Naomi
N
Runnegar
David
D
Looke
Chris
C
Schmidt
Siok-Keen
SK
Tey
Glen
G
Kennedy
Maher K
MK
Gandhi
D000293:Adolescent; D002648:Child; D004854:Herpesvirus 4, Human / Q000276:immunology* / Q000302:isolation & purification*; D006801:Humans; D007244:Infectious Mononucleosis / Q000175:diagnosis* / Q000276:immunology* / Q000628:therapy; D007376:Interleukin-2 / Q000172:deficiency; D053645:Interleukin-2 Receptor alpha Subunit / Q000172:deficiency; D011948:Receptors, Antigen, T-Cell / Q000172:deficiency; D012008:Recurrence; D033581:Stem Cell Transplantation; D013601:T-Lymphocytes / Q000276:immunology; D014775:Virus Activation; D055815:Young Adult
D007376:Interleukin-2; D053645:Interleukin-2 Receptor alpha Subunit; D011948:Receptors, Antigen, T-Cell