CD56brightCD16- natural killer cells accumulate in the ovarian follicular fluid of patients undergoing in vitro fertilization.
CD56(bright)CD16(-) natural killer (NK) cells that express CXCR3 accumulate in the follicular fluid of patients with a good response to ovarian stimulation. It is conceivable that granulosa cells of good responders that express the chemokine CXCL10 recruit these NK cells to support follicular angiogenesis.
Fainaru
Ofer
O
Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto Centre for Advanced Reproductive Technology, Toronto, Ontario, Canada.
Amsalem
Hagai
H
Bentov
Yaakov
Y
Esfandiari
Navid
N
Casper
Robert F
RF
D000328:Adult; D019002:CD56 Antigen / Q000378:metabolism*; D002465:Cell Movement; D054357:Chemokine CXCL10 / Q000378:metabolism; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000166:cytology*; D006107:Granulosa Cells / Q000378:metabolism; D006801:Humans; D007247:Infertility, Female / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D054315:Oocyte Retrieval; D054367:Receptors, CXCR3 / Q000378:metabolism; D017452:Receptors, IgG / Q000378:metabolism*
D019002:CD56 Antigen; C114753:CXCL10 protein, human; C515187:CXCR3 protein, human; D054357:Chemokine CXCL10; D054367:Receptors, CXCR3; D017452:Receptors, IgG