A comparison of nephron number, glomerular volume and kidney weight in Senegalese Africans and African Americans.
BACKGROUND
Low nephron number is determined in utero and is a proposed risk for essential hypertension. Glomerular volume is inversely correlated with nephron number, and genetic and environmental factors that determine nephron number are thought to determine glomerular volume. This study compared total glomerular (nephron) number (N(glom)), mean glomerular volume (V(glom)) and kidney weight in two geographically separated black populations with significant common genetic ancestry.


METHODS
Unbiased stereology was used to determine N(glom) and V(glom) in kidneys collected at coronial autopsy in an age- and sex-matched sample of 39 adult Africans from Dakar in Senegal, West Africa and 39 African Americans from Mississippi in the USA.


RESULTS
African Americans were taller and heavier than their Senegalese counterparts. N(glom) was remarkably similar-with a geometric mean of 937 967 in Senegalese and 904 412 in African Americans (P = 0.62). V(glom) was correlated inversely with N(glom) and directly with body surface area in both groups, but V(glom) was 54% greater in African Americans than in Senegalese Africans [8.30 +/- 2.92 (SD) and 5.38 +/- 1.25 microm(3) x 10(6), respectively] and remained significantly larger (38%) after adjustment for body size. V(glom) increased with age in African Americans, but not in the Senegalese. Kidney weight was larger in African Americans (P < 0.0001), but kidney-to-body weight ratio was not different between groups.


CONCLUSIONS
Despite similar nephron numbers, a common genetic constitution, and even in relation to current body size, African Americans have larger V(glom) than Senegalese subjects. This may mark exposure to environmental stressors or hereditary traits concentrated in the population's relocation to North America.
Department of Anatomy and Developmental Biology, Monash University, Melbourne, Australia.
Bridgette J
BJ
McNamara
Boucar
B
Diouf
Rebecca N
RN
Douglas-Denton
Michael D
MD
Hughson
Wendy E
WE
Hoy
John F
JF
Bertram
D000328:Adult; D001741:Black or African American / Q000235:genetics*; D000367:Age Factors; D044383:Black People / Q000235:genetics*; D001830:Body Surface Area; D002423:Cause of Death; D005260:Female; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000473:pathology; D007678:Kidney Glomerulus / Q000033:anatomy & histology*; D008297:Male; D008875:Middle Aged; D009399:Nephrons / Q000033:anatomy & histology; D009929:Organ Size; D012675:Senegal