Genetic association study of KREMEN1 and DKK1 and schizophrenia in a Japanese population.
The aim of the current study was to examine the association of KREMEN1 and DKK1, two wnt pathway-related genes with schizophrenia in Japanese subjects. We genotyped 16 common genetic variants within the aforementioned genes and examined their associations with schizophrenia. Results demonstrated that a common variant in the promoter region of KREMEN1 might modulate the risk of schizophrenia in the Japanese. However, further replication will be needed for conclusive interpretation of the effect of this locus on the pathogenesis of schizophrenia.
Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Japan. branko@med.nagoya-u.ac.jp
Branko
B
Aleksic
Itaru
I
Kushima
Yoshihito
Y
Ito
Yukako
Y
Nakamura
Hiroshi
H
Ujike
Michio
M
Suzuki
Toshiya
T
Inada
Ryota
R
Hashimoto
Masatoshi
M
Takeda
Nakao
N
Iwata
Norio
N
Ozaki
D000328:Adult; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*; D007564:Japan / Q000208:ethnology; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D051153:Wnt Proteins / Q000235:genetics
C501126:DKK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; C486075:KREMEN1 protein, human; D008565:Membrane Proteins; D051153:Wnt Proteins