In vivo dentin remineralization by calcium-phosphate cement.
Minimally invasive caries-removal procedures remove only caries-infected dentin and preserve caries-affected dentin that becomes remineralized. Dental cements containing calcium phosphate promote remineralization. This study evaluated the in vivo remineralization capacity of resin-based calcium-phosphate cement (Ca-P) used for indirect pulp-capping. Carious and sound teeth indicated for extraction were randomly restored with the Ca-P base or without base (control), followed by adhesive restoration. Study teeth were extracted after three months, followed by elemental analysis of the cavity floor. Mineral content of affected or sound dentin at the cavity floor was quantified by electron probe micro-analysis to 100-mum depth. After three months, caries-affected dentin underneath the Ca-P base showed significantly increased calcium and phosphorus content to a depth of 30 mum. Mineral content of treated caries-affected dentin was in the range of healthy dentin, revealing the capacity of Ca-P base to promote remineralization of caries-affected dentin.
University of Michigan, School of Dentistry, Department of Cariology, Restorative Sciences and Endodontics, Room 2345, 1100 N. University, Ann Arbor, MI 48109, USA. mcpete@umich.edu
M C
MC
Peters
E
E
Bresciani
T J E
TJ
Barata
T C
TC
Fagundes
R L
RL
Navarro
M F L
MF
Navarro
S H
SH
Dickens
D000328:Adult; D002118:Calcium / Q000032:analysis; D002130:Calcium Phosphates / Q000032:analysis / Q000627:therapeutic use; D003731:Dental Caries / Q000628:therapy*; D003736:Dental Cavity Lining; D003737:Dental Cavity Preparation / Q000379:methods; D003793:Dental Restoration, Permanent / Q000379:methods*; D003804:Dentin / Q000737:chemistry / Q000187:drug effects*; D004577:Electron Probe Microanalysis; D006801:Humans; D016014:Linear Models; D010758:Phosphorus / Q000032:analysis; D011446:Prospective Studies; D019279:Resin Cements / Q000737:chemistry / Q000627:therapeutic use*; D018709:Statistics, Nonparametric; D014089:Tooth Remineralization / Q000379:methods*; D016896:Treatment Outcome
D002130:Calcium Phosphates; D019279:Resin Cements; D010758:Phosphorus; C020243:calcium phosphate; D002118:Calcium