The relationship between disease-related characteristics and conduction disturbances in ankylosing spondylitis.
OBJECTIVE
Ankylosing spondylitis (AS) is associated with an increased cardiovascular (CV) risk. Conduction disturbances (CD) may explain the CV burden, as they are independently associated with cardiac disease. The aim of this study was (i) to determine the prevalence of CD in AS, and (ii) to evaluate the relationship between CD and demographic and AS-related characteristics.


METHODS
A rheumatological evaluation assessing demographic and AS-related characteristics and a resting standard 12-lead electrocardiogram (ECG) were performed in 131 consecutive AS patients.


RESULTS
A first-degree atrioventricular (AV) block was found in six (4.6%) patients. One (0.8%) patient suffered from a complete right bundle branch block (RBBB) and one (0.8%) patient had a left anterior hemiblock. A prolonged QRS (pQRS) interval was observed in 38 (29.2%) patients, including those with a complete or incomplete BBB. Age, disease duration, and body mass index (BMI) were significantly associated with the PR interval, and male gender, disease duration, and the Bath Ankylosing Spondylitis Metrology Index (BASMI) with the QRS interval. In multivariate analyses, disease duration remained independently associated with both the PR and the QRS intervals.


CONCLUSIONS
Intraventricular CD is highly prevalent in AS, particularly in patients with long-standing disease. Further research is needed to determine whether intraventricular CD contribute to the increased CV risk and long-term CV mortality in AS.
Department of Rheumatology, VU University Medical Centre, Amsterdam, The Netherlands.
V K
VK
Dik
M J L
MJ
Peters
P A
PA
Dijkmans
M A C
MA
Van der Weijden
M K
MK
De Vries
B A C
BA
Dijkmans
I E
IE
Van der Horst-Bruinsma
M T
MT
Nurmohamed
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000704:Analysis of Variance; D001145:Arrhythmias, Cardiac / Q000175:diagnosis* / Q000453:epidemiology*; D054537:Atrioventricular Block / Q000175:diagnosis / Q000453:epidemiology; D002037:Bundle-Branch Block / Q000175:diagnosis / Q000453:epidemiology; D015331:Cohort Studies; D015897:Comorbidity; D016001:Confidence Intervals; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006329:Heart Conduction System / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012720:Severity of Illness Index; D017678:Sex Distribution; D013167:Spondylitis, Ankylosing / Q000175:diagnosis / Q000453:epidemiology*; D015996:Survival Rate; D055815:Young Adult