USP10: friend and foe.
The tumor suppressor protein p53, a crucial player in the DNA damage response, is regulated in many ways, most notably through ubiquitination. In this issue, Yuan et al. (2010) identify the deubiquitinating protease USP10 as a new regulator of p53 in the DNA damage response and tumor development.
Jochemsen
Aart G
AG
Department of Molecular Cell Biology, Leiden University Medical Center, 2300RC Leiden, The Netherlands. a.g.jochemsen@lumc.nl
Shiloh
Yosef
Y
D004260:DNA Repair; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D043222:Ubiquitin Thiolesterase / Q000378:metabolism*; D054875:Ubiquitination
C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C431363:USP10 protein, human; D043222:Ubiquitin Thiolesterase