Interleukin-1 resets glucose homeostasis at central and peripheral levels: relevance for immunoregulation.
We briefly discuss here evidence showing that the capacity of IL-1beta to mediate adjustments of glucose homeostasis can be added to the already well-known pleiotropic effects of this cytokine. Such adjustments, which are necessary for satisfying the high energetic demands of immune/inflammatory responses, can be mediated by effects of endogenous IL-1 exerted at peripheral and brain levels in a concerted action with other cytokines and neuroendocrine mechanisms.
Department of Immunophysiology, Institute of Physiology and Pathophysiology, Medical Faculty, Marburg, Germany. besedovs@mailer.uni-marburg.de
Hugo O
HO
Besedovsky
Adriana
A
Del Rey
D000818:Animals; D004734:Energy Metabolism / Q000276:immunology*; D005947:Glucose / Q000378:metabolism*; D051275:Glucose Transporter Type 4 / Q000378:metabolism; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000502:physiology; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D053583:Interleukin-1beta / Q000378:metabolism*; D015213:Neuroimmunomodulation / Q000502:physiology*
D051275:Glucose Transporter Type 4; D007328:Insulin; D053583:Interleukin-1beta; D005947:Glucose