Indoleamine 2,3-dioxygenase in tumor induced tolerance.
OBJECTIVE
To review the recent studies about the role of indoleamine 2,3-dioxygenase (IDO) in tumor induced tolerance.


METHODS
Published articles (1978 - 2009) on IDO and tumor induced tolerance were selected from Medline.


METHODS
Articles selected were relevant to development of IDO in tumor induced tolerance. Of all originally identified articles, 50 specially addressed the stated purpose.


RESULTS
Recent work has revealed IDO at high levels in tumors and in tumor-draining lymph nodes and a close relationship between IDO activity and the regulatory T cells.


CONCLUSIONS
Up-regulation of IDO is proven to be a mechanism of acquired tolerance in tumors, in which the closely coupled positive feedback system between IDO and regulatory T cells may be considered to play an important role.
Liu
Xiao-Qian
XQ
Department of Hematology, Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, China.
Wang
Xin
X
D000818:Animals; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology*; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology* / Q000276:immunology*
D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase