[Experimental model in rats for the development of pseudoarthrosis].
OBJECTIVE
We sought to describe a new model of pseudoarthrosis in rats free of pathogenic species (Rattus norvegicus albinus - SPF).


METHODS
The animals were randomly distributed into two groups were used: Group 1 - Control (n =6); Group 2 - Experimental (n =6). In the Control group an access to the femur followed by the synthesis of the muscular and skin layers was done. The Experimental group was submitted to osteotomy of the femur and a pedicle flap of the fascia lata was interposed between the segments resulting from the surgically induced fracture. The procedure was carried on with both alignment and approximation of the fractured bone through the use of mononylon thread introduced into holes created in the proximal and distal.


RESULTS
Radiological and anatomopathological studies showed the absence of bone consolidation with persistence of fibro-osteoid tissue up to 120 days of follow-up.


CONCLUSIONS
The experimental model is suitable for the development of a pseudoarthrosis in rats.
Ferreira
Manoel Luiz
ML
Departamento de Cirurgia, Faculdade de Medicina, UFRJ, Rio de Janeiro, RJ, BR.
Silva
Paulo Cesar
PC
Pereira
Lara de Paula Miranda
Lde P
Franco
Renata Schueler
RS
Mello
Natalia Bernades
NB
Amaral
Alessandra Cintra
AC
Schanaider
Alberto
A
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005599:Fractures, Ununited / Q000150:complications*; D008297:Male; D010027:Osteotomy / Q000379:methods*; D011542:Pseudarthrosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D011859:Radiography; D011897:Random Allocation; D051381:Rats