Study of Pt/TiO2 nanocomposite for cancer-cell treatment.
The increasing incidence of cancer all over the world demands new, effective and secure materials for treatment. In this paper, we propose Pt/TiO(2) nanocomposite for cancer-cell treatment because noble metal nanoparticles are supposed to enhance the photocatalytic activity of TiO(2) nanoparticles. To evaluate the cancer-cell killing effect of our Pt/TiO(2) nanocomposite, TiO(2) and Au/TiO(2) nanoparticles are also introduced. The prepared Pt/TiO(2) nanocomposite are characterized with transmission electron microscopy (TEM) and UV-vis adsorption spectra. Results of cell treatment indicate that Pt/TiO(2) nanocomposite, as extremely stable metal-semiconductor nanomaterial, can exhibit a very high photodynamic efficiency under a mild ultraviolet radiation. And our Pt/TiO(2) nanocomposite shows to be more effective in cancer-cell treatment than TiO(2) and Au/TiO(2) nanoparticles. As a result, Pt/TiO(2) nanocomposite may be supposed to have a promising application for cancer-cell treatment.
Department of Biochemistry and National Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.
Lei
L
Liu
Peng
P
Miao
Yuanyuan
Y
Xu
Zhipeng
Z
Tian
Zhigang
Z
Zou
Genxi
G
Li
D002470:Cell Survival / Q000187:drug effects* / Q000528:radiation effects; D006367:HeLa Cells; D006801:Humans; D049329:Nanostructures / Q000627:therapeutic use* / Q000648:ultrastructure; D010316:Particle Size; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D010984:Platinum / Q000627:therapeutic use*; D014025:Titanium / Q000627:therapeutic use*; D016896:Treatment Outcome; D014467:Ultraviolet Therapy / Q000379:methods*
D017319:Photosensitizing Agents; C009495:titanium dioxide; D010984:Platinum; D014025:Titanium