Common polymorphisms of Fibulin-5 and the risk of abdominal aortic aneurysm development.
Fibulin-5 is a crucial protein in the connective tissue structure of the aortic wall. The purpose of this study was to determine if genetic variation within the Fibulin-5 gene was associated with abdominal aortic aneurysms (AAA). AAA patients, with disease-free controls, were recruited and a past medical history questionnaire completed. Three single nucleotide polymorphisms (SNPs) in the FBLN5 gene (rs2498834, rs2430366 and rs2254320) were genotyped. The two cohorts were compared and haplotype analysis performed. A total of 230 AAA cases and 278 controls were successfully genotyped. The mean age was 71.9 years (+/- 6.8). No difference between cases and controls was found in the distribution of alleles of FBLN5 SNPs rs2498834 (p = 0.47), rs2430366 (p = 0.45) or rs2254320 (p = 0.46). Haplotype analysis did not reveal any significant difference. In conclusion, genetic variation within FBLN5 is unlikely to play any role in the development of AAA.
Vascular and Endovascular Surgery Department, Belfast City Hospital, Belfast, Northern Ireland. Stephen@Badger.tc
Stephen A
SA
Badger
Chee V
CV
Soong
Mark E
ME
O'Donnell
Mohammed A
MA
Sharif
Ragai R
RR
Makar
Anne E
AE
Hughes
D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000453:epidemiology* / Q000235:genetics*; D002883:Chromosomes, Human, Pair 14; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006239:Haplotypes; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012307:Risk Factors
D016326:Extracellular Matrix Proteins; C492373:FBLN5 protein, human