Crystal structure of HIV-1 reverse transcriptase bound to a non-nucleoside inhibitor with a novel mechanism of action.
Architecture et réactivité de l'ARN, Université de Strasbourg, CNRS, Institut de Biologie Moléculaire et Cellulaire, 15 rue René Descartes, 67084 Strasbourg, France.
Séverine
S
Freisz
Guillaume
G
Bec
Marco
M
Radi
Philippe
P
Wolff
Emmanuele
E
Crespan
Lucilla
L
Angeli
Philippe
P
Dumas
Giovanni
G
Maga
Maurizio
M
Botta
Eric
E
Ennifar
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000627:therapeutic use; D018360:Crystallography, X-Ray; D017320:HIV Protease Inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D054303:HIV Reverse Transcriptase / Q000737:chemistry* / Q000378:metabolism; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry*; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D008954:Models, Biological; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D011728:Pyridones / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D018894:Reverse Transcriptase Inhibitors / Q000737:chemistry* / Q000627:therapeutic use; D014753:Vinyl Compounds / Q000737:chemistry*
C550503:4-dimethylamino-6-vinylpyrimidine; C517167:5-methyl-1-(4-nitrophenyl)-2-oxo-2,5-dihydro-1H-pyrido(3,2-b)indole-3-carbonitrile; D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D006575:Heterocyclic Compounds, 3-Ring; D007211:Indoles; D009570:Nitriles; D011728:Pyridones; D011743:Pyrimidines; D018894:Reverse Transcriptase Inhibitors; C550501:VRX-329747; C550502:VRX-413638; D014753:Vinyl Compounds; C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase