Pediatric reference intervals for immunoglobulin G and its subclasses with Siemens immunonephelometric assays.
OBJECTIVE
To determine the pediatric reference intervals for the Dade Behring IgG subclass reagents.


METHODS
Blood samples of healthy children and adolescents were analyzed to determine the level of immunoglobulin G (IgG) and the IgG subclass using the reagents of Dade Behring Marburg GmbH.


RESULTS
The reference intervals categorized by age were reported from a total of 436 samples. There was an excellent correlation between the total IgG and the sum of the IgG subclasses.


CONCLUSIONS
Our data provide the missing pediatric reference intervals and enable the use of the Dade Behring nephelometric IgG subclass reagents in children and adolescents.
Department of Pathology and Laboratory Medicine, Children's Hospital of Eastern Ontario, Ottawa, Canada.
Nathalie
N
Lepage
Shih-Han S
SH
Huang
Ed
E
Nieuwenhuys
Guido
G
Filler
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007223:Infant; D008297:Male; D009391:Nephelometry and Turbidimetry / Q000379:methods* / Q000592:standards; D012016:Reference Values
D007074:Immunoglobulin G