Asymmetric binary-acid catalysis with chiral phosphoric acid and MgF(2): catalytic enantioselective Friedel-Crafts reactions of beta,gamma-unsaturated alpha-ketoesters.
A unique binary chiral phosphoric acid 1a/MgF(2) catalyst that enables effective catalysis of asymmetric Friedel-Crafts reactions of phenols with up to 82% yield and >99% ee is presented. A dramatic synergistic effect has been observed in the combinations of two types of acids, wherein a highly active binary-acid catalyst can be generated from two individually inert acids.
Lv
Jian
J
Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Li
Xin
X
Zhong
Long
L
Luo
Sanzhong
S
Cheng
Jin-Pei
JP