Modulation of CD86 expression in skin dendritic cells does not always correlate with changes in DC motility, migration and allostimulatory functions.
CD86 expression is a well-known activation marker of dendritic cells (DC). In this study, we compared the level of CD86 expression in monocyte-derived skin DC with their motility, migratory abilities and allostimulatory capabilities. We show that motility and migration could be uncoupled from activation and that the immune response-modulating effects of certain compounds may correlate with down-regulation of CD86 expression rather than with effects on motility and migration.
Bechetoille
Nicolas
N
BASF Beauty Care Solutions, 32 rue Saint Jean de Dieu, 69007 Lyon, France. nicolas.bechetoille@basf.com
Boher
Aurélie
A
Gaydon
Amandine
A
Andre-Frei
Valérie
V
D051940:B7-2 Antigen / Q000187:drug effects*; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D032301:Cestrum; D003907:Dexamethasone / Q000494:pharmacology; D005434:Flow Cytometry; D005938:Glucocorticoids / Q000494:pharmacology; D006801:Humans; D007801:Langerhans Cells / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects*
D051940:B7-2 Antigen; D005938:Glucocorticoids; D010936:Plant Extracts; D003907:Dexamethasone