Cortical gamma-oscillations modulated by auditory-motor tasks-intracranial recording in patients with epilepsy.
Human activities often involve hand-motor responses following external auditory-verbal commands. It has been believed that hand movements are predominantly driven by the contralateral primary sensorimotor cortex, whereas auditory-verbal information is processed in both superior temporal gyri. It remains unknown whether cortical activation in the superior temporal gyrus during an auditory-motor task is affected by laterality of hand-motor responses. Here, event-related γ-oscillations were intracranially recorded as quantitative measures of cortical activation; we determined how cortical structures were activated by auditory-cued movement using each hand in 15 patients with focal epilepsy. Auditory-verbal stimuli elicited augmentation of γ-oscillations in a posterior portion of the superior temporal gyrus, whereas hand-motor responses elicited γ-augmentation in the pre- and postcentral gyri. The magnitudes of such γ-augmentation in the superior temporal, precentral, and postcentral gyri were significantly larger when the hand contralateral to the recorded hemisphere was required to be used for motor responses, compared with when the ipsilateral hand was. The superior temporal gyrus in each hemisphere might play a greater pivotal role when the contralateral hand needs to be used for motor responses, compared with when the ipsilateral hand does.
Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit Medical Center, Detroit, Michigan 48201, USA.
Tetsuro
T
Nagasawa
Robert
R
Rothermel
Csaba
C
Juhász
Miho
M
Fukuda
Masaaki
M
Nishida
Tomoyuki
T
Akiyama
Sandeep
S
Sood
Eishi
E
Asano
D000161:Acoustic Stimulation; D000293:Adolescent; D001931:Brain Mapping; D058256:Brain Waves / Q000502:physiology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D002648:Child; D003463:Cues; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009068:Movement / Q000502:physiology