[Recovery of the cardiovascular system and the state of its autonomic regulation after prior long hemorrhagic shock during vaccination with tetanus and diphtheria anatoxins].
Tetanus anatoxin was shown to have a stimulant effect on the cardiovascular system and its autonomic regulation, which produced a longer posthemorrhagic survival in the controls with the least pronounced dystrophic changes in the myocardium. Prior vaccination with diphtheria anatoxins was found to promote animals' survival, by reducing reperfusion injury in the presence of long-term systemic hypoperfusion, early exhaustion of sympathetic autonomic cardiac rhythm regulation, and myocardial dystrophic and necrobiotic changes resulting in the development of cardiosclerosis.
A V
AV
Chizhikov
D A
DA
Enikeev
D000818:Animals; D022422:Diphtheria-Tetanus Vaccine / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D006321:Heart / Q000294:innervation / Q000503:physiopathology*; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000503:physiopathology*; D009206:Myocardium / Q000473:pathology; D020127:Recovery of Function / Q000187:drug effects*; D012771:Shock, Hemorrhagic / Q000150:complications / Q000503:physiopathology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D013997:Time Factors; D014611:Vaccination
D022422:Diphtheria-Tetanus Vaccine