In vivo intravascular ultrasound analysis of the absorption rate of the Angio-Seal vascular closure device in the porcine femoral artery.
OBJECTIVE
Device-based arterial closure is currently used to achieve haemostasis following percutaneous intervention. Little is known about the in vivo patterns of device absorption. We aimed to characterise the absorption dynamics following implantation of the Angio-Seal VIP closure device (AVCD) (St. Jude Medical, St. Paul, MN, USA) by using serial intravascular ultrasound (IVUS) and histology.


RESULTS
Eleven AVCD were implanted following 6 Fr femoral arterial sheath in six pigs. Using carotid access, angiograms and IVUS were performed at baseline, 3, 5, 7, 14, 30 and 42 days following deployment. At termination, arteries were processed for histology at 14 (n=3), 30(n=4) and 42 days (n=4). By IVUS, following implantation the intravascular component (IC) area remained unchanged up to 14 days and decreased by 50% at 30 days and 95% by 42 days. By histology, there was a progressive decline in the IC area at 14 days and decrease by 30% at 30 days and 77% by 42 days. Histology demonstrated almost complete absorption of the IC and no signs of severe chronic granulomatous inflammation.


CONCLUSIONS
IVUS serial imaging demonstrated almost complete absorption of the IC by 42 days in normal porcine femoral arteries. There was no evidence of severe chronic granulomatous vascular inflammation demonstrated by histology.
Tellez
Armando
A
The Cardiovascular Research Foundation and Skirball Center for Cardiovascular Research, Orangeburg, NY 10962, USA.
Cheng
Yanping
Y
Yi
Geng-Hua
GH
Conditt
Gerard B
GB
McGregor
Jennifer C
JC
Flynn
Alyssa M
AM
Ordanes
Diane
D
Mintz
Gary S
GS
Kaluza
Greg L
GL
Granada
Juan F
JF
D020341:Absorbable Implants; D000818:Animals; D004195:Disease Models, Animal; D004867:Equipment Design; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000601:surgery*; D006488:Hemostasis, Surgical / Q000295:instrumentation*; D019919:Prosthesis Implantation / Q000379:methods*; D011677:Punctures; D020127:Recovery of Function; D013552:Swine; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional / Q000379:methods*