Homocysteine and pro-inflammatory cytokine concentrations in acute heart disease.
Inflammation is involved in development and progression of atherosclerosis. Interleukin-2 (IL-2) and interleukin-6 (IL-6) have been correlated with various cardiovascular diseases. Hyperhomocysteinemia is an important risk factor for atherosclerosis and thrombotic disease. Recent studies have demonstrated that homocysteine (Hcy) enhances productions of several pro-inflammatory cytokines. In the light of these findings, we decided to determine if any relationship exists between IL-2 and IL-6, the pro-inflammatory cytokines, and total homocysteine (tHcy) in acute coronary syndrome (ACS). A total of 102 patients with ACS and 90 healthy subjects were included in the study. The levels of tHcy, IL-2 and IL-6 were higher and folic acid was lower in patients as compared with those of controls. Furthermore, data of the area under ROC plot for IL-2 demonstrated that IL-2 had higher sensitivity. These data suggest that enhanced inflammation may be associated with tHcy-related cardiovascular disease.
Department of Biochemistry, Istanbul University, Turkey. cahgok@istanbul.edu.tr
Cahide
C
Gokkusu
Feti
F
Tulubas
Yesim
Y
Unlucerci
Elif
E
Ozkok
Berrin
B
Umman
Makbule
M
Aydin
D002318:Cardiovascular Diseases / Q000097:blood* / Q000150:complications*; D016022:Case-Control Studies; D003710:Demography; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000150:complications*; D007376:Interleukin-2 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged; D012372:ROC Curve; D014805:Vitamin B 12 / Q000097:blood
D007376:Interleukin-2; D015850:Interleukin-6; D006710:Homocysteine; D005492:Folic Acid; D014805:Vitamin B 12