A comparative clinical study evaluating stain removal efficacy of a new sensitivity whitening dentifrice compared to commercially available whitening dentifrices.
OBJECTIVE
To assess the extrinsic stain removal efficacy of a new sensitivity dentifrice containing sodium tripolyphosphate (STP) to marketed whitening toothpastes after six weeks of product use.


METHODS
This was a single-center, double-blind, stratified, six-week clinical study comparing the reduction in stain area and intensity of Sensodyne Extra Whitening to Crest Maximum Strength Sensitivity Protection Whitening plus Scope and Colgate Tartar Control Plus Whitening Mint dentifrice, as measured by MacPherson's Modification of the Lobene Stain Index (MMLSI) in a forced stain model.


RESULTS
Two-hundred and ninety-five subjects completed the study. Tooth stain MMSLI scores showed significant differences between Sensodyne and Crest dentifrices in favor of Sensodyne for all surface sites (p = 0.014), and individually for facial (p = 0.023), lingual (p = 0.027), and interproximal (p = 0.014) surfaces. No significant statistical differences between Sensodyne and Colgate dentifrices were observed for any of the surfaces.


CONCLUSIONS
Results from this stain removal clinical study demonstrate significant extrinsic stain removal efficacy for all dentifrices relative to baseline. Significant differences between the two marketed sensitivity whitening dentifrices were demonstrated in favor of the new Sensodyne Sensitivity Whitening dentifrice.
GlaxoSmithKline Consumer Healthcare, Weybridge, UK. nathan.l.hughes@gsk.com
Nathan
N
Hughes
Brenda
B
Maggio
Farzana
F
Sufi
Stephen
S
Mason
Carl J
CJ
Kleber
D000328:Adult; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D057133:Dentin Desensitizing Agents / Q000627:therapeutic use; D003807:Dentin Sensitivity / Q000150:complications / Q000188:drug therapy; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011122:Polyphosphates / Q000627:therapeutic use; D012907:Smoking; D014075:Tooth Discoloration / Q000150:complications / Q000188:drug therapy*
D003802:Dentifrices; D057133:Dentin Desensitizing Agents; D011122:Polyphosphates; C005692:triphosphoric acid