[Maturation of the autonomic nervous system: differences in heart rate variability at different gestational weeks].
OBJECTIVE
Heart rate variability (HRV) reveals information on the functional state of the autonomic nervous system (ANS). This study was initiated to assess the physiological and maturational development of the ANS by comparing HRV data of a large number healthy foetus of different gestational ages from the 24(th) to the 42(nd) week.


METHODS
Cardiotocogram (CTG) recordings of HRV of 172 healthy foetus (24-42 weeks' gestation) were performed to establish normative data. Frequency domain HRV parameters were computed in three frequency bands.


RESULTS
The gestational ages of the foetuses correlate with HRV. Lower gestational age in weeks showed lower frequency domain parameters than higher gestational age in weeks. The most significant differences were discerned for HRV parameters reflecting sympathetic activity in LF (low frequency) and VLF (very low frequency), due to the adrenergic system.


CONCLUSIONS
Maturation of the ANS is accompanied by increasing HRV with a pronounced increase of sympathetic activity. These changes are measurable by CTG recordings with a computer algorithm which can calculate short-term variability on the basis of CTG data. Problems of the CTG signal, as shown before, were the parameters of the time domain, which could only be well detected by ECG or foetal magnetocardiography (FMCG).
Universitätskinderklinik Heidelberg, Heidelberg. thorsten-gerstner@web.de
T
T
Gerstner
J
J
Sprenger
T
T
Schaible
C
C
Weiss
S
S
Koenig
D000375:Aging / Q000502:physiology*; D001341:Autonomic Nervous System / Q000196:embryology* / Q000502:physiology*; D005318:Fetal Heart / Q000196:embryology* / Q000294:innervation / Q000502:physiology*; D005865:Gestational Age; D006339:Heart Rate / Q000502:physiology*; D006801:Humans