Echocardiographic analysis with a two-dimensional strain of chronic myocardial ischemia induced with ameroid constrictor in the pig.
Despite much progress in the medical management of myocardial ischemia, several problems remain and experimental models help to improve our understanding of the pathophysiology involved in this domain. The ameroid constrictor model is the most widely used to create ischemia but evaluation of patent ischemia is still under debate. In the present study, we describe the potential of a two-dimensional (2D) strain for experimentally evaluating myocardial ischemia in the pig. An ameroid constrictor was placed around the circumflex artery in 30 pigs. Angiography showed 90% stenosis at one and two months. Left ventricular function was moderately altered and associated with mitral valve insufficiency in 30% of cases. Longitudinal and circumference strains were dramatically modified in the ischemic inferior-lateral zone compared to the healthy anterior zone (P<0.01) at one and two months. We correlated these results to myocardial ischemia by using contrast echocardiography, which showed a significant reduction in myocardial perfusion in the ischemic zone compared to the uninjured area, and by using histological analysis. We showed that evaluation of the 2D strain could be an interesting approach for assessing myocardial ischemia after ameroid constrictor implantation. The 2D strain represents a useful tool for the evaluation of experimental models of myocardial ischemia.
Inserm U 828, Avenue du Haut-Lévêque, 33600 Pessac, France.
Dominique
D
Caillaud
Joachim
J
Calderon
Patricia
P
Réant
Stéphane
S
Lafitte
Pierre
P
Dos Santos
Thierry
T
Couffinhal
Xavier
X
Roques
Laurent
L
Barandon
D000704:Analysis of Variance; D000818:Animals; D001707:Biopsy, Needle; D002364:Caseins; D002908:Chronic Disease; D017023:Coronary Angiography / Q000379:methods; D023921:Coronary Stenosis / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D004195:Disease Models, Animal; D004452:Echocardiography / Q000379:methods*; D020100:Hydrogels; D007150:Immunohistochemistry; D008297:Male; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D011897:Random Allocation; D013552:Swine; D016277:Ventricular Function, Left / Q000502:physiology
D002364:Caseins; D020100:Hydrogels; C009719:ameroid