A lipid-soluble red ginseng extract inhibits the growth of human lung tumor xenografts in nude mice.
Lipid-soluble ginseng extract was prepared by n-hexane extraction of red ginseng. BALB/c-nu mice were inoculated with human lung cancer (NCI-H460) cells to establish a human tumor xenograft model in nude mice, and the lipid-soluble ginseng extract was orally administered. The tumor inhibitory rates of the lipid-soluble ginseng extract at doses of 0.1, 0.3, and 1.0 g/kg/day were 18.9% (P < .05), 60.0% (P < .001), and 67.5% (P < .001), respectively. The oral administration of the lipid-soluble extract of red ginseng showed a potent anticancer effect in nude mice bearing human lung cancer cells in a dose-dependent manner without any apparent toxicity. This lipid-soluble ginseng extract is a potential nontoxic anticancer supplement for the prevention and intervention of lung tumor growth through an oral administration route.
Lee
Sung Dong
SD
Department of Food and Nutrition, College of Health Science, Korea University, Seoul, Republic of Korea.
Park
Song-Kyu
SK
Lee
Eun Sil
ES
Kim
Hwan Mook
HM
Lee
Chang Woo
CW
Lee
Kiho
K
Lee
Ki Hoon
KH
Kang
Moo Rim
MR
Lee
Kwang Seung
KS
Lee
Junsoo
J
Hwang
Woo Ik
WI
Kim
Dong Chung
DC
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008055:Lipids; D008175:Lung Neoplasms / Q000188:drug therapy*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D005894:Panax; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D012995:Solubility; D023041:Xenograft Model Antitumor Assays
D000972:Antineoplastic Agents, Phytogenic; D008055:Lipids; D010936:Plant Extracts