Glycodynamers: dynamic polymers bearing oligosaccharides residues--generation, structure, physicochemical, component exchange, and lectin binding properties.
Dynamic glycopolymers have been generated by polycondensation through acylhydrazone formation between components bearing lateral bioactive oligosaccharide chains. They have been characterized as bottlebrush type by cryo-TEM and SANS studies. They present remarkable fluorescence properties whose emission wavelengths depend on the constitution of the polymer and are tunable by constitutional modification through exchange/incorporation of components, thus also demonstrating their dynamic character. Constitution-dependent binding of these glycodynamers to a lectin, peanut agglutinin, has been demonstrated.
Laboratoire de Chimie Supramoléculaire, ISIS, Université de Strasbourg, 67000 Strasbourg, France.
Yves
Y
Ruff
Eric
E
Buhler
Sauveur-Jean
SJ
Candau
Ellina
E
Kesselman
Yeshayahu
Y
Talmon
Jean-Marie
JM
Lehn