Small Silencing RNAs: Piecing Together a Viral Genome.
Virus-derived small interfering RNAs (siRNAs) are the hallmark of RNAi-based antiviral immunity. Wu and colleagues demonstrate how viral genomes can be assembled from these small RNA sequences. Their results provide an approach for virus discovery as well as important insights into how these siRNAs mediate antiviral defense.
Department of Medical Microbiology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Nijmegen Institute for Infection, Inflammation and Immunity, 6500 HB Nijmegen, The Netherlands.
Joël T
JT
van Mierlo
Koen W R
KW
van Cleef
Ronald P
RP
van Rij