Liver disease in pregnancy.
Severe liver disease in pregnancy is rare. Pregnancy-related liver disease is the most frequent cause of liver dysfunction in pregnancy and provides a real threat to fetal and maternal survival. A rapid diagnosis differentiating between liver disease related and unrelated to pregnancy is required in women who present with liver dysfunction during pregnancy. Research has improved our understanding of the pathogenesis of pregnancy-related liver disease, which has translated into improved maternal and fetal outcomes. Here, we provide an overview of liver diseases that occur in pregnancy, an update on the key mechanisms involved in their pathogenesis, and assessment of available treatment options.
Institute of Liver Studies, King's College Hospital, London, UK.
Deepak
D
Joshi
Andra
A
James
Alberto
A
Quaglia
Rachel H
RH
Westbrook
Michael A
MA
Heneghan
D002780:Cholestasis, Intrahepatic / Q000175:diagnosis; D004461:Eclampsia / Q000175:diagnosis; D005234:Fatty Liver / Q000175:diagnosis; D005260:Female; D017359:HELLP Syndrome / Q000175:diagnosis; D006801:Humans; D006939:Hyperemesis Gravidarum / Q000175:diagnosis; D008107:Liver Diseases / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D016031:Liver Transplantation; D011225:Pre-Eclampsia / Q000175:diagnosis; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000628:therapy; D011256:Pregnancy Outcome; D011379:Prognosis; D012307:Risk Factors