Overview of developmental and reproductive toxicity research in China: history, funding mechanisms, and frontiers of the research.
Reproductive and developmental toxicology (DART) is the discipline that deals with adverse effects on male and female resulting from exposures to harmful chemical and physical agents. DART research in China boasted a long history, but presently has fallen behind the western world in education and research. The funding mechanisms for DART research in China were similar to that for other toxicological disciplines, and the funding has come from research grants and fellowships provided by national, ministerial, and provincial institutions. Finally, the frontiers of DART research in China could be summarized as follows: (1) use of model animals such as the zebrafish and roundworm, and use of cutting-edge techniques such as stem cell culture, as well as transgenic, metabonomic, and virtual screening to study the mechanisms of developmental toxicity for some important toxicants in China; (2) use of model animals and other lower-level sentinel organisms to evaluate and monitor the developmental toxicogical risk of environmental chemicals or pollutants; (3) epidemiological studies of some important reproductive hazards; (4) in-depth studying of the reproductive and developmental toxicity of some important environmental chemicals; and (5) evaluation and study of the reproductive and developmental toxicity of traditional Chinese medicines.
Wu
Chunqi
C
National Beijing Center for Drug Safety Evaluation and Research, Beijing Institute of Toxicology and Pharmacology, PR China. wuchunqi64@sohu.com
D000014:Abnormalities, Drug-Induced / Q000175:diagnosis*; D000818:Animals; D002681:China; D002986:Clinical Trials as Topic; D000013:Congenital Abnormalities / Q000175:diagnosis / Q000209:etiology; D004195:Disease Models, Animal; D005260:Female; D005333:Fetus / Q000187:drug effects; D006801:Humans; D008297:Male; D018811:Maternal Exposure; D018812:Paternal Exposure; D012098:Reproduction / Q000187:drug effects; D012106:Research / Q000639:trends; D012107:Research Design; D012109:Research Support as Topic