Melatonin as a potential tool against oxidative damage and apoptosis in ejaculated human spermatozoa.
It is assumed somatic cells can die in the apoptotic, the autophagic, or the necrotic way; however, the mechanisms of sperm death are not clear. Here, ejaculated human spermatozoa were evaluated for apoptosis and reactive oxygen species production in the absence or presence of melatonin, and we concluded that melatonin reverses sperm apoptosis due to its free radical scavenging actions.
Department of Physiology, Faculty of Science, University of Extremadura, Badajoz, Spain.
Javier
J
Espino
Ignacio
I
Bejarano
Agueda
A
Ortiz
Graciela M
GM
Lozano
Juan F
JF
García
José A
JA
Pariente
Ana B
AB
Rodríguez
D017209:Apoptosis / Q000187:drug effects*; D053148:Caspase 3 / Q000378:metabolism; D053453:Caspase 9 / Q000378:metabolism; D004542:Ejaculation; D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism; D013094:Spermatozoa / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology
D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide; D053148:Caspase 3; D053453:Caspase 9; D008550:Melatonin