Evaluation of antinociceptive and anti-inflammatory activities of a new triterpene saponin from Bauhinia variegata leaves.
A new triterpene saponin, named as 23-hydroxy-3alpha-[O-alpha-L-1C4-rhamnopyranosyl-(1"-->4')-O-alpha-L-4C1-arabinopyranosyl-oxy]olean-12-en-28-oic acid O-alpha-L-1C4-rhamnopyranosyl-(1""'-->4"")-O-beta-D-4C1-glucopyranosyl-(1""-->6"')-O-beta-D-4C1-glucopyranosyl ester (9), was isolated from the leaves of Bauhinia variegata Linn. In addition, six flavonoid compounds along with two cinnamic acid derivatives were isolated and identified based on their chromatographic properties, and chemical and spectral data (ESI-high resolution-MSn, 1H NMR, 13C NMR, 1H-1H COSY, HSQC, and HMBC). Compound 9 was found to be nontoxic (LD50) and to have significant anti-inflammatory and antinociceptive activities. It also showed a slight antischistosomal activity.
Department of Medicinal Chemistry, Theodor Bilharz Research Institute (TBRI), Giza, Egypt.
Mona A
MA
Mohamed
Madeha R
MR
Mammoud
Heiko
H
Hayen
D000700:Analgesics / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology; D036481:Bauhinia / Q000737:chemistry*; D015232:Dinoprostone / Q000097:blood / Q000378:metabolism; D004534:Egypt; D005260:Female; D006099:Granuloma / Q000188:drug therapy / Q000378:metabolism; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry*; D051381:Rats; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012555:Schistosomiasis mansoni / Q000188:drug therapy; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D012503:Saponins; D014315:Triterpenes; D015232:Dinoprostone