Multiple paraneoplastic diseases occurring in the same patient after thymomectomy.
Thymoma-associated paraneoplastic diseases include myasthenia gravis (MG), neuromyotonia (NMT), Morvan's syndrome, and several non-neurological paraneoplastic manifestations, including glomerulonephritis. Paraneoplastic syndromes often precede the occurrence of thymoma, but cases occurring after thymomectomy, which sometimes herald the recurrence of thymoma, have also been described. We report on a patient who developed MG after thymomectomy for a malignant thymoma. After MG remission, NMT and Morvan's syndrome occurred, which heralded a mediastinic recurrence, as demonstrated only by autopsy findings.
Departments of Neurosciences, University of Padova, Via Giustiniani 5, 35128 Padova, Italy. chiara.briani@unipd.it
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Briani
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Cagnin
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Blandamura
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Altavilla
D000328:Adult; D017809:Fatal Outcome; D006801:Humans; D020386:Isaacs Syndrome / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D009157:Myasthenia Gravis / Q000188:drug therapy / Q000209:etiology*; D010257:Paraneoplastic Syndromes / Q000188:drug therapy / Q000209:etiology*; D011379:Prognosis; D013595:Syringomyelia / Q000188:drug therapy / Q000209:etiology*; D013934:Thymectomy / Q000009:adverse effects*; D013945:Thymoma / Q000601:surgery*; D013953:Thymus Neoplasms / Q000601:surgery*