Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris.
BACKGROUND
Low-energy shock wave (SW) therapy has improved myocardial ischemia in both a porcine model and in patients with severe angina pectoris.


RESULTS
To further confirm the effectiveness and safety of SW therapy, 8 patients with severe angina pectoris were treated with SW therapy in a double-blind, placebo-controlled and cross-over manner. SW therapy, but not placebo, significantly improved chest pain symptoms and cardiac function without any complications or adverse effects.


CONCLUSIONS
Extracorporeal cardiac SW therapy is an effective, safe and non-invasive therapeutic option for severe angina pectoris.
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Yoku
Y
Kikuchi
Kenta
K
Ito
Yoshitaka
Y
Ito
Takashi
T
Shiroto
Ryuji
R
Tsuburaya
Kentaro
K
Aizawa
Kiyotaka
K
Hao
Yoshihiro
Y
Fukumoto
Jun
J
Takahashi
Morihiko
M
Takeda
Masaharu
M
Nakayama
Satoshi
S
Yasuda
Shinichi
S
Kuriyama
Ichiro
I
Tsuji
Hiroaki
H
Shimokawa
D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000628:therapy*; D002637:Chest Pain / Q000628:therapy*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008096:Lithotripsy / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000009:adverse effects / Q000379:methods*
D010919:Placebos