Changes of circulating transforming growth factor-beta1 level during radiation therapy are correlated with the prognosis of locally advanced non-small cell lung cancer.
BACKGROUND
We hypothesized that plasma transforming growth factor-beta1 (TGF-beta1) level and its dynamic change are correlated with the prognosis of locally advanced non-small cell lung cancer (NSCLC) treated with radiation therapy (RT).


METHODS
Patients with stage IIIA or IIIB NSCLC treated with RT with or without chemotherapy were eligible for this study. Platelet poor plasma was collected from each patient within 1 week before RT (pre-RT) and at the 4th week during RT (during-RT). TGF-beta1 level was measured with enzyme-linked immunosorbent assay. The primary end point was overall survival (OS) and the secondary end point was progression-free survival (PFS). Kaplan-Meier and Cox regression were used for risk factor evaluation.


RESULTS
A total of 65 patients were eligible for the study. The median OS and PFS were 17.7 and 13.7 months, respectively. In univariate analysis, performance status, weight loss, radiation dose, and TGF-beta1 ratio (during-RT/pre-RT TGF-beta1 level) were all significantly correlated with OS. In the multivariate analysis, performance status, radiation dose, and TGF-beta1 ratio were still significantly correlated with OS. The median OS was 30.7 months for patients with TGF-beta1 ratio <or=1 versus 13.3 months for those with TGF-beta1 ratio more than 1 (p = 0.0029); and the median PFS was 16.8 months versus 7.2 months, respectively (p = 0.010).


CONCLUSIONS
In locally advanced NSCLC, the decrease of TGF-beta1 level during RT is correlated with favorable prognosis.
Department of Radiation Oncology, Cancer Hospital (Institute), Peking Union Medical College, Chinese Academy of Medical Science, Beijing, China.
Lujun
L
Zhao
Wei
W
Ji
Li
L
Zhang
Guangfei
G
Ou
Qinfu
Q
Feng
Zongmei
Z
Zhou
Mingfang
M
Lei
Weizhi
W
Yang
Luhua
L
Wang
D000230:Adenocarcinoma / Q000097:blood / Q000473:pathology / Q000532:radiotherapy; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000473:pathology / Q000532:radiotherapy*; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000473:pathology / Q000532:radiotherapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000473:pathology / Q000532:radiotherapy; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D053773:Transforming Growth Factor beta1 / Q000097:blood*; D016896:Treatment Outcome
C508960:TGFB1 protein, human; D053773:Transforming Growth Factor beta1