Bioactive bromophycolides R-U from the Fijian red alga Callophycus serratus.
Four new bromophycolides, R-U (1-4), were isolated from the Fijian red alga Callophycus serratus and were identified by 1D and 2D NMR and mass spectroscopic analyses. These compounds expand the known structural variety of diterpene-benzoate macrolides and exhibited modest cytotoxicity toward selected human cancer cell lines. Bromophycolide S (2) also showed submicromolar activity against the human malaria parasite Plasmodium falciparum.
School of Biology and School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA.
An-Shen
AS
Lin
E Paige
EP
Stout
Jacques
J
Prudhomme
Karine
K
Le Roch
Craig R
CR
Fairchild
Scott G
SG
Franzblau
William
W
Aalbersberg
Mark E
ME
Hay
Julia
J
Kubanek
D000666:Amphotericin B / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004351:Drug Resistance / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D016984:Enterococcus faecium / Q000187:drug effects; D005260:Female; D005367:Fiji; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D010963:Plasmodium falciparum / Q000187:drug effects; D000461:Rhodophyta / Q000737:chemistry*; D014640:Vancomycin / Q000494:pharmacology
D000962:Antimalarials; D004224:Diterpenes; D018942:Macrolides; D014640:Vancomycin; D000666:Amphotericin B