Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases.
A bioinformatic search was carried for plant homologues of human serine-threonine protein kinases involved in regulation of cell division and microtubule protein phosphorylation (SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK4 and PASK). A number of SLK, MAST2 and AURKA plant homologues were identified. The closest identified homologue of human AURKA kinase was a protein of unknown function, A7PY12/GSVIVT00026259001 from Vitis vinifera (herein named as "STALK", Serine-Threonine Aurora-Like Kinase). Analysis of STALK's three-dimensional structure confirmed its relationship to the subgroup of AURKA-like protein kinases.
Karpov
Pavel A
PA
Institute of Food Biotechnology and Genomics, National Academy of Sciences of Ukraine, Kyiv, Ukraine. karpov.p.a@gmail.com
Nadezhdina
Elena S
ES
Yemets
Alla I
AI
Matusov
Vadym G
VG
Nyporko
Alexey Yu
AY
Shashina
Nadezhda Yu
NY
Blume
Yaroslav B
YB
D000595:Amino Acid Sequence; D001665:Binding Sites; D055162:Biocatalysis; D002453:Cell Cycle; D019295:Computational Biology; D017124:Conserved Sequence; D006801:Humans; D008870:Microtubules / Q000201:enzymology*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010766:Phosphorylation; D010802:Phylogeny; D010944:Plants / Q000201:enzymology* / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment; D040681:Structural Homology, Protein
D017346:Protein Serine-Threonine Kinases