Seroprevalence of Entamoeba histolytica in the context of HIV and AIDS: the case of Vhembe district, in South Africa's Limpopo province.
In a recent study in northern South Africa, the seroprevalence of Entamoeba histolytica infection among 257 HIV-positive and 117 HIV-negative individuals was determined, using an ELISA for the detection of antibodies reacting with the parasite's galactose/-acetyl-D-galactosamine(Gal/GalNAc)-inhibitable adherence lectin. Overall, 34.0% of the 374 participants (36.1% of the females and 28.1% of the males) were found seropositive for E. histolytica. Although all age-groups were affected by the amoebic pathogen, the subjects aged 50-59 years had the highest seroprevalence (69.2%). The seroprevalence of E. histolytica was also significantly higher among the HIV-positive subjects than among the HIV-negative (42.8% v. 14.5%; chi(2)=28.65; P<0.0001). Among the HIV-positive subjects, those with fewer than 200 CD4+ cells/microl were relatively more likely to be seropositive for E. histolytica (60.3% v. 43.8%; chi(2)=4.016; P=0.045). This is the first report indicating a positive association between E. histolytica infection and HIV in South Africa. Further studies, for example to determine the occurrence of diarrhoea or liver abscess in the study area, in relation to seropositivity for E. histolytica and/or HIV, are now needed.
AIDS Virus Research Laboratory, Department of Microbiology, University of Venda Private Bag X5050, Thohoyandou 0950, Limpopo Province, South Africa. samie.amidou@univen.ac.za
A
A
Samie
L J
LJ
Barrett
P O
PO
Bessong
J N
JN
Ramalivhana
L G
LG
Mavhandu
M
M
Njayou
R L
RL
Guerrant
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology; D018791:CD4 Lymphocyte Count; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D004748:Entamoeba histolytica / Q000276:immunology* / Q000302:isolation & purification; D004749:Entamoebiasis / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000469:parasitology; D005260:Female; D006678:HIV / Q000276:immunology; D015483:HIV Antibodies / Q000276:immunology; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000175:diagnosis / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D007223:Infant; D037102:Lectins / Q000276:immunology; D008101:Liver Abscess, Amebic / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction / Q000379:methods; D011247:Pregnancy; D016036:Seroepidemiologic Studies; D013019:South Africa / Q000453:epidemiology; D055815:Young Adult
D000913:Antibodies, Protozoan; D015483:HIV Antibodies; D037102:Lectins