Glial cell line-derived neurotrophic factor is increased in cerebrospinal fluid but decreased in blood during long-term pain.
Glial cell line-derived neurotrophic factor (GDNF) is involved in inflammation and pain, roles which remain to be delineated clinically. We aimed to evaluate the role of central nervous and peripheral GDNF in long-term pain patients and in controls by analysing intrathecal and blood concentrations of GDNF. Simultaneous measurements of pro-inflammatory cytokines IL-1beta, TNF-alpha and IL-6, anti-inflammatory cytokine IL-10 and chemokine IL-8 served to define inflammatory responses. Generally, blood levels of GDNF were higher than corresponding intrathecal levels. Pain was associated with levels of GDNF that were increased intrathecally, but decreased in blood. IL-8 was uniformly higher in pain patients.
Department of Anaesthesiology and Intensive Care Medicine, Institute of Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, 413 45 Gothenburg, Sweden. christopher.lundborg@vgregion.se
Christopher
C
Lundborg
Mirjana
M
Hahn-Zoric
Björn
B
Biber
Elisabeth
E
Hansson
D000368:Aged; D000369:Aged, 80 and over; D019643:Arthroplasty, Replacement; D015415:Biomarkers / Q000032:analysis / Q000097:blood / Q000134:cerebrospinal fluid; D002490:Central Nervous System / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D018925:Chemokines / Q000032:analysis / Q000097:blood / Q000134:cerebrospinal fluid; D002908:Chronic Disease; D016207:Cytokines / Q000032:analysis / Q000097:blood / Q000134:cerebrospinal fluid; D004185:Disability Evaluation; D015536:Down-Regulation / Q000276:immunology; D005260:Female; D051100:Glial Cell Line-Derived Neurotrophic Factor / Q000032:analysis / Q000097:blood* / Q000134:cerebrospinal fluid*; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis / Q000097:blood* / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood / Q000134:cerebrospinal fluid / Q000503:physiopathology; D010147:Pain Measurement; D010148:Intractable Pain / Q000097:blood* / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D017933:Peripheral Nervous System / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D015854:Up-Regulation / Q000276:immunology
D015415:Biomarkers; D018925:Chemokines; D016207:Cytokines; D051100:Glial Cell Line-Derived Neurotrophic Factor; D018836:Inflammation Mediators