Telomeric TuRF1 wars.
The TRF1 subunit of the shelterin complex controls telomere length by regulating telomerase access to chromosome ends. Work from Zeng et al. (2010) now reveals in atomic detail how a battle between the SCF(FBX4) ubiquitin ligase and the shelterin component TIN2 controls TRF1 abundance and telomere length homeostasis.
Sarraf
Shireen A
SA
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Harper
J Wade
JW
D006801:Humans; D008954:Models, Biological; D044843:SKP Cullin F-Box Protein Ligases / Q000378:metabolism; D000089804:Shelterin Complex; D016615:Telomere / Q000235:genetics* / Q000378:metabolism*; D034501:Telomere-Binding Proteins / Q000378:metabolism; D035321:Telomeric Repeat Binding Protein 1 / Q000378:metabolism*
D000089804:Shelterin Complex; C440868:TINF2 protein, human; D034501:Telomere-Binding Proteins; D035321:Telomeric Repeat Binding Protein 1; D044843:SKP Cullin F-Box Protein Ligases