C-C chemokine receptor 1 expression in human hematolymphoid neoplasia.
Chemokine receptor 1 (CCR1) is a G protein-coupled receptor that binds to members of the C-C chemokine family. Recently, CCL3 (MIP-1alpha), a high-affinity CCR1 ligand, was identified as part of a model that independently predicts survival in patients with diffuse large B-cell lymphoma (DLBCL). However, the role of chemokine signaling in the pathogenesis of human lymphomas is unclear. In normal human hematopoietic tissues, we found CCR1 expression in intraepithelial B cells of human tonsil and granulocytic/monocytic cells in the bone marrow. Immunohistochemical analysis of 944 cases of hematolymphoid neoplasia identified CCR1 expression in a subset of B- and T-cell lymphomas, plasma cell myeloma, acute myeloid leukemia, and classical Hodgkin lymphoma. CCR1 expression correlated with the non-germinal center subtype of DLBCL but did not predict overall survival in follicular lymphoma. These data suggest that CCR1 may be useful for lymphoma classification and support a role for chemokine signaling in the pathogenesis of hematolymphoid neoplasia.
Dept. of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
Matthew W
MW
Anderson
Shuchun
S
Zhao
Weiyun Z
WZ
Ai
Robert
R
Tibshirani
Ronald
R
Levy
Izidore S
IS
Lossos
Yasodha
Y
Natkunam
D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism*; D016009:Chi-Square Distribution; D016000:Cluster Analysis; D006098:Granulocytes / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism*; D008223:Lymphoma / Q000378:metabolism*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism; D014066:Palatine Tonsil / Q000378:metabolism*; D054389:Receptors, CCR1 / Q000378:metabolism*
C515300:CCR1 protein, human; D009363:Neoplasm Proteins; D054389:Receptors, CCR1