Synthesis and antiviral activity of an imidazo[1,2-a]pyrrolo[2,3-c]pyridine series against the bovine viral diarrhea virus.
A series of imidazo[1,2-a]pyrrolo[2,3-c]pyridines has been prepared and evaluated for their anti-BVDV activities in MDBK cells. From the synthesized analogues bearing modifications of the substituents at positions 2, 3, 7 and 8, compounds 10a, b, 16, 24, 25 and 26 exhibited significant anti-BVDV activities.
Chezal
Jean-Michel
JM
Clermont Université, University Clermont 1, EA 4231, Clermont-Ferrand F-63001, France. j-michel.chezal@u-clermont1.fr
Paeshuyse
Jan
J
Gaumet
Vincent
V
Canitrot
Damien
D
Maisonial
Aurélie
A
Lartigue
Claire
C
Gueiffier
Alain
A
Moreau
Emmanuel
E
Teulade
Jean-Claude
JC
Chavignon
Olivier
O
Neyts
Johan
J
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001908:Diarrhea Viruses, Bovine Viral / Q000187:drug effects*; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D007093:Imidazoles; D011725:Pyridines; D011758:Pyrroles