The relationship between antidepressant use and smoking cessation in pregnant women in treatment for substance abuse.
BACKGROUND
Bupropion's efficacy for smoking cessation in pregnant women is unknown.


OBJECTIVE
To determine if substance-dependent women prescribed bupropion smoked fewer cigarettes/day than those prescribed citalopram/escitalopram or no antidepressant medication.


METHODS
Comparison of smoking in bupropion (n = 11), citalopram/escitalopram (n = 17), and no antidepressant (n = 28) groups.


CONCLUSIONS
Trend for greater decrease in smoking for the bupropion vs. citalopram/escitalopram group [-6.4 vs. -.4 cigarettes/day (p = .276)], although the bupropion decrease was similar to that seen in the no antidepressant group [-5.3 cigarettes/day].


CONCLUSIONS
Data support continued study of bupropion in depressed pregnant substance-dependent smokers.
The Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. mchisol1@jhmi.edu
Margaret S
MS
Chisolm
Emily P
EP
Brigham
Michelle
M
Tuten
Eric C
EC
Strain
Hendrée E
HE
Jones
D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D016642:Bupropion / Q000627:therapeutic use*; D015283:Citalopram / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000150:complications / Q000188:drug therapy*; D017831:Diagnosis, Dual (Psychiatry); D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D037841:Pregnant People / Q000523:psychology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use; D012907:Smoking / Q000188:drug therapy*; D016540:Smoking Cessation / Q000523:psychology*; D019966:Substance-Related Disorders / Q000150:complications / Q000188:drug therapy*; D016896:Treatment Outcome
D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion; D015283:Citalopram; D017367:Selective Serotonin Reuptake Inhibitors