[Specific features of cardiac insufficiency in elderly patients with chronic renal disease].
OBJECTIVE
To evaluate clinical features of chronic cardiac insufficiency (CCI) in elderly patients with renal dysfunction.


METHODS
260 patents (143 men and 117 women) aged above 60 (mean 68.7 +/- 6.6) yr with I-IV FC CCI. 25 patients had hypertensive disease (HD), 30 coronary heart disease (CHD), 205 HD+CHD. Glomerular filtration rate (GFR) was estimated using MDRD formula.


RESULTS
Chronic renal disease (CRD) with GFR reduced below 60 ml/min/1.73 m2 was diagnosed in 126 (48.5%) patients. Its severity was not significantly different between patients with and without CCI. (2.3 +/- 0.7 and 2.1 +/- 0.7 respectively, p = 0.13). The entire study group was dominated by men, the CCI group by women. Atrial fibrillation (AF) was diagnosed in 25.8% of the patients with CI + CRD. Multivariate regression analysis revealed independent correlation of AF with CCI FC (p = 0.02) and GFR (p = 0.2). CCI patients with CRD had higher frequency of mitral regurgitation (MR) than without CRD. Occurrence of MR correlated with age (p < 0.001) and GFR (p < 0.001).


CONCLUSIONS
1. Renal dysfunction occurred in 48.55% of elderly patients with CCI. 2. A distinctive clinical feature of CCI + CRD in elderly patients is frequent development of AF and MR. 3. CCI + CRD is more frequent in women and CCI without CRD in men.
V A
VA
Serov
A M
AM
Shutov
S V
SV
Khiteeva
E R
ER
Makeeva
S I
SI
Serova
O V
OV
Troshen'kina
D000368:Aged; D018450:Disease Progression; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D005919:Glomerular Filtration Rate; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013318:Stroke Volume / Q000502:physiology*; D013599:Systole; D016277:Ventricular Function, Left / Q000502:physiology*