Chromosome 9p and 10q losses predict unfavorable outcome in low-grade gliomas.
The loss of chromosomes 1p-19q is the only prognostic molecular alteration identified in low-grade gliomas (LGGs) to date. Search for loss of heterozygosity (LOH) on chromosomes 1p, 9p, 10q, and 19q was performed in a series of 231 LGGs. Loss of chromosomes 1p-19q was strongly correlated with prolonged progression-free survival (PFS) and overall survival (OS) in univariate and multivariate analyses. LOH on 9p and 10q were associated with shortened PFS (P = .01 and .03, respectively) on univariate analysis. On multivariate analysis, LOH on 9p remained significant for PFS (P = .05), whereas LOH on 10q had a significant effect on OS (P = .02). Search for LOH 9p and 10q appears to be a useful complement to analysis of chromosomes 1p-19q in LGGs.
Service de Neurologie 2 - Mazarin, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France. carolinehouillier@yahoo.fr
Caroline
C
Houillier
Karima
K
Mokhtari
Catherine
C
Carpentier
Emmanuelle
E
Crinière
Yannick
Y
Marie
Audrey
A
Rousseau
Gentian
G
Kaloshi
Caroline
C
Dehais
Julien
J
Laffaire
Florence
F
Laigle-Donadey
Khê
K
Hoang-Xuan
Marc
M
Sanson
Jean-Yves
JY
Delattre
D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000235:genetics* / Q000401:mortality; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D018572:Disease-Free Survival; D005260:Female; D005910:Glioma / Q000235:genetics* / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D019656:Loss of Heterozygosity; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult