Glutamate transporter gene (SLC1A1) single nucleotide polymorphism (rs301430) and repetitive behaviors and anxiety in children with autism spectrum disorder.
Investigated association of single nucleotide polymorphism (SNP) rs301430 in glutamate transporter gene (SLC1A1) with severity of repetitive behaviors (obsessive-compulsive behaviors, tics) and anxiety in children with autism spectrum disorder (ASD). Mothers and/or teachers completed a validated DSM-IV-referenced rating scale for 67 children with autism spectrum disorder. Although analyses were not significant for repetitive behaviors, youths homozygous for the high expressing C allele had more severe anxiety than carriers of the T allele. Allelic variation in SLC1A1 may be a biomarker for or modifier of anxiety symptom severity in children with ASD, but study findings are best conceptualized as tentative pending replication with larger independent samples.
Department of Psychiatry, Stony Brook University, New York, NY, USA. kenneth.gadow@stonybrook.edu
Kenneth D
KD
Gadow
Jasmin
J
Roohi
Carla J
CJ
DeVincent
Sarah
S
Kirsch
Eli
E
Hatchwell
D000293:Adolescent; D000483:Alleles; D001007:Anxiety / Q000150:complications / Q000235:genetics* / Q000523:psychology; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000150:complications / Q000235:genetics* / Q000523:psychology; D002675:Child, Preschool; D050580:Excitatory Amino Acid Transporter 3 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000235:genetics / Q000523:psychology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D019956:Stereotypic Movement Disorder / Q000150:complications / Q000235:genetics* / Q000523:psychology
D050580:Excitatory Amino Acid Transporter 3; C493400:SLC1A1 protein, human