Synovial sarcoma of the chest wall.
We here report a rare case of synovial sarcoma of the chest wall. A 71-year-old Japanese woman noticed a left anterior chest wall mass after twice having had surgery for lung cancer. An aspiration biopsy diagnosed synovial sarcoma. She then underwent a surgical resection. Pathology examination revealed a biphasic-type synovial sarcoma. When the prepared RNA from the tumor was subjected to a polymerase chain reaction, SYT-SSX1 fusion gene transcripts were demonstrated. Patients with the SYT-SSX1 fusion gene have a worse clinical outcome than patients with SYT-SSX2-positive tumors. After a second surgery, performed in 1 year later, there was no evidence of recurrence for 30 months; however, careful observation may be required.
Kawano
Daigo
D
Department of Surgery and Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan. daigo-k9@surg2.med.kyushu-u.ac.jp
Yoshino
Ichiro
I
Shoji
Fumihiro
F
Morodomi
Yosuke
Y
Yano
Tokujiro
T
Maehara
Yoshihiko
Y
D000368:Aged; D001707:Biopsy, Needle; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D011237:Predictive Value of Tests; D018714:Radiotherapy, Adjuvant; D012086:Reoperation; D013584:Sarcoma, Synovial / Q000235:genetics / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D013899:Thoracic Neoplasms / Q000235:genetics / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D019616:Thoracic Surgical Procedures; D035441:Thoracic Wall / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D015514:Oncogene Proteins, Fusion; C116512:SYT-SSX fusion protein