[Regulation of allergic immune response of PPARgamma agonists--emerging roles in allergic response].
PPARgamma is expressed in a variety of immunocompetent cells and has immunoregulatory activities. In line with the in vitro observations that PPARgamma agonists down-regulate inflammatory cytokines production and cellular responses, PPARgamma agonists have protective effects in a variety of mouse model of inflammatory disorders. In this review, we summarize the functional roles of PPARgamma in immunocompetent cells from the perspective of the pathophysiology of allergic diseases. The anti-allergic effects of PPARgamma agonist in vitro and in vivo indicate the possibility that PPARgamma agonists could be new therapeutic modality for allergic disease.
Chihara
Junichi
J
Department of Infection, Allergy, Clinical Immunology and Laboratory Medicine, Akita University Graduate School of Medicine.
Takeda
Masahide
M
Ueki
Shigeharu
S
D000818:Animals; D006967:Hypersensitivity / Q000188:drug therapy*; D007121:Immunocompetence / Q000187:drug effects; D051379:Mice; D047495:PPAR gamma / Q000819:agonists*
D047495:PPAR gamma