"Click" labeling strategy for M(CO)(3) (M = Re, (99m)Tc) prostate cancer targeted flutamide agents.
Two distinct "click" chemistry labeling approaches were investigated with dipyridylamine alkyne derivatives and M(CO)(3)(+) (M = Re, (99m)Tc). The triazole ring was found uncoordinated and was incorporated into the preparation of a crossover androgen receptor targeting inhibitor for prostate cancer.
Moore
Adam L
AL
Department of Chemistry, Washington State University, PO Box 644630, Pullman, WA 99164, USA. bennyp@wsu.edu.
Bucar
Dejan-Kresimir
DK
Macgillivray
Leonard R
LR
Benny
Paul D
PD
D018360:Crystallography, X-Ray; D005485:Flutamide / Q000737:chemistry*; D006801:Humans; D007553:Isotope Labeling; D008297:Male; D008968:Molecular Conformation; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000737:chemistry*; D011944:Receptors, Androgen / Q000032:analysis* / Q000737:chemistry; D012211:Rhenium / Q000737:chemistry*; D013667:Technetium / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry
D019275:Radiopharmaceuticals; D011944:Receptors, Androgen; D014230:Triazoles; D012211:Rhenium; D013667:Technetium; D005485:Flutamide