Regulation of metabolism in Caenorhabditis elegans longevity.
The nematode Caenorhabditis elegans is a favorite model for the study of aging. A wealth of genetic and genomic studies show that metabolic regulation is a hallmark of life-span modulation. A recent study in BMC Biology identifying metabolic signatures for longevity suggests that amino-acid pools may be important in longevity.
Gallo
Marco
M
Department of Medical Genetics, Faculty of Medicine, 263-2185 East Mall, The University of British Columbia, Vancouver, BC V6T1Z4, Canada.
Riddle
Donald L
DL
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000375:Aging / Q000235:genetics / Q000378:metabolism; D000818:Animals; D017173:Caenorhabditis elegans / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D017238:Genes, Helminth / Q000502:physiology; D008017:Life Expectancy; D050356:Lipid Metabolism / Q000502:physiology; D008136:Longevity / Q000235:genetics / Q000502:physiology*; D023421:Models, Animal; D009154:Mutation; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology; D011401:Promoter Regions, Genetic / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013696:Temperature
D029742:Caenorhabditis elegans Proteins; D000255:Adenosine Triphosphate