Heat treatment of electrospun silicate fiber substrates enhances cellular adhesion and proliferation.
Synthetic scaffolds support cell attachment in vitro. We prepared ultra-fine silicate fibers using the sol-gel process and electrospinning, heated the fibers to 500 degrees C and investigated their effects on the behavior of human hepatocellular carcinoma (HepG2) cells. Alterations in surface composition following heat treatment improved cell adhesion and influenced cell migration.
Biotechnology and Food Research Institute, Fukuoka Industrial Technology Center, 1465-5 Aikawa, Kurume, Fukuoka 839-0861, Japan. tetsu@fitc.pref.fukuoka.jp
Tetsu
T
Yamaguchi
Shinji
S
Sakai
Rie
R
Watanabe
Takashi
T
Tarao
Koei
K
Kawakami
D002448:Cell Adhesion / Q000502:physiology*; D049109:Cell Proliferation; D004563:Electrochemistry / Q000379:methods*; D056945:Hep G2 Cells; D006358:Hot Temperature; D006801:Humans; D008422:Materials Testing; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D012399:Rotation; D017640:Silicates / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
D017640:Silicates