Strawberry consumption is associated with increased antioxidant capacity in serum.
Strawberries are known to contain antioxidants, but the significance of ingesting antioxidant-rich fruits remains to be established. In order to determine whether the consumption of strawberries impacted measures of in vivo antioxidant capacity, frozen strawberries (250 g) were administered daily for 3 weeks to 21 healthy female volunteers. Compliance was confirmed by quantitating pelargonidin-glucuronide, urolithin A-glucuronide, and 2,5-dimethyl-4-hydroxy-3-[(2)H]furanone-glucuronide in plasma and urine by liquid chromatography-mass spectrometry and antioxidant capacity in serum measured by the increase in lag phase of low-density lipoprotein after copper sulfate exposure, DNA strand breaks in lymphocytes, and activity of phase II enzymes. Among these measures lipid peroxidation lag time increased by 20% (P < .01), whereas other measures did not change significantly. The potent antioxidant defenses in humans make determination of changes due to dietary ingestion in healthy individuals difficult. In summary, daily consumption of strawberries resulted in a modest but significant increase in antioxidant capacity in a healthy population.
Henning
Susanne M
SM
Center for Human Nutrition, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA. shenning@mednet.ucla.edu
Seeram
Navindra P
NP
Zhang
Yanjun
Y
Li
Luyi
L
Gao
Kun
K
Lee
Ru-Po
RP
Wang
David C
DC
Zerlin
Alona
A
Karp
Hannah
H
Thames
Gail
G
Kotlerman
Jenny
J
Li
Zhaoping
Z
Heber
David
D
D000328:Adult; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology*; D008078:Cholesterol, LDL / Q000378:metabolism; D004032:Diet; D005260:Female; D031985:Fragaria; D005638:Fruit; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D010349:Patient Compliance; D028321:Plant Preparations / Q000494:pharmacology*; D013997:Time Factors; D055815:Young Adult
D000975:Antioxidants; D008078:Cholesterol, LDL; D028321:Plant Preparations