Protease inhibitors: a panacea?
With the increasing evidence of protease involvement in several diseases, novel strategies for drug development involve the use of protease inhibitors (PIs). The local balance between protease inhibitors and proteases is an important determinant of the occurrence and progression of a particular disease. Hence, enzymes and their cognate inhibitors are finding their applications as diagnostic and prognostic markers. PIs are widely implicated for their use in host defense against infection, tissue repair and matrix production, blood coagulation, cancer, and they are, therefore, the current focus as therapeutic alternatives for major diseases such as AIDS and Alzheimer's diseases. This review is a brief summary of the varied role of protein protease inhibitors in controlling the activity of aberrant enzymes in several diseases afflicting mankind today.
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh 202002, India.
Soghra Khatun
SK
Haq
Gulam
G
Rabbani
Ejaz
E
Ahmad
Sheikh Muhammad
SM
Atif
Rizwan Hasan
RH
Khan
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000201:enzymology; D000544:Alzheimer Disease / Q000188:drug therapy / Q000201:enzymology; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000201:enzymology; D001249:Asthma / Q000188:drug therapy / Q000201:enzymology; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000201:enzymology; D004646:Emphysema / Q000188:drug therapy / Q000201:enzymology; D006373:Helminthiasis / Q000188:drug therapy / Q000201:enzymology; D006801:Humans; D007239:Infections / Q000188:drug therapy / Q000201:enzymology; D009181:Mycoses / Q000188:drug therapy / Q000201:enzymology; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology; D010024:Osteoporosis / Q000188:drug therapy / Q000201:enzymology; D011480:Protease Inhibitors / Q000627:therapeutic use*; D011528:Protozoan Infections / Q000188:drug therapy / Q000201:enzymology; D012909:Snake Bites / Q000188:drug therapy / Q000201:enzymology
D011480:Protease Inhibitors