Association study of single nucleotide polymorphisms on chromosome 19q13 with abdominal aortic aneurysm.
BACKGROUND
Abdominal aortic aneurysm (AAA) is a complex disorder in which environmental and genetic factors play a role in pathogenesis. Linkage to 2 adjacent loci on 19q13 in familiar AAA was previously demonstrated. We studied whether genetic variation within these regions predisposes to AAA.


METHODS
Common genetic variants in the described regions on 19q13 were analyzed using tag single nucleotide polymorphisms (SNPs) in a Dutch case-control population. Single nucleotide polymorphism genotyping was performed in a 2-stage approach.


RESULTS
In stage 1, 615 SNPs were genotyped in 376 AAA patients and 648 controls. In stage 2, 8 SNPs of stage 1 with a P value < .015 were genotyped in a second independent cohort of 360 cases and 376 controls. No differences in allele frequencies were observed.


CONCLUSIONS
Our findings suggest that there are no common AAA predisposing SNPs within the 19q13 loci. Hence, the genetic basis of familiar and sporadic AAA may differ.
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands. a.f.baas@umcutrecht.nl
Annette F
AF
Baas
Jelena
J
Medic
Ruben
R
van't Slot
Jean-Paul P M
JP
de Vries
Marc R H M
MR
van Sambeek
Bob H
BH
Geelkerken
Bart P
BP
Boll
Diederick E
DE
Grobbee
Cisca
C
Wijmenga
Ynte M
YM
Ruigrok
Jan D
JD
Blankensteijn
D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000235:genetics*; D002888:Chromosomes, Human, Pair 19; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide