The evolution of protease mutation 76V is associated with protease mutation 46I and gag mutation 431V.
Recently, first-line lopinavir failure was observed due to protease mutation 76V. In the present study, we found 76V associated with protease mutation 46I and gag cleavage-site mutation 431V. Longitudinal analysis of patients failing protease inhibitor therapies demonstrated that 76V strictly occurs either together with 46I and/or 431V or in HIV isolates already harbouring one of both mutations. Therefore, all three mutations seem to cooperate in terms of protease inhibitor resistance.
Knops
Elena
E
University of Cologne, Institute of Virology, Cologne, Germany.
Kemper
Ina
I
Schülter
Eugen
E
Pfister
Herbert
H
Kaiser
Rolf
R
Verheyen
Jens
J
D024882:Drug Resistance, Viral / Q000235:genetics*; D019143:Evolution, Molecular; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D061466:Lopinavir; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D011744:Pyrimidinones / Q000627:therapeutic use; D017422:Sequence Analysis, DNA; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000235:genetics*; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics*
D017320:HIV Protease Inhibitors; D011744:Pyrimidinones; D054301:gag Gene Products, Human Immunodeficiency Virus; D054302:pol Gene Products, Human Immunodeficiency Virus; D061466:Lopinavir