Stem cell therapies for ocular surface disease.
Transparency of the cornea on the front surface of the eye is essential for vision. A variety of blinding ocular surface diseases involve the cornea. This review focusses on vision loss caused by disruption of the integrity and function of the outermost corneal layer (the epithelium) and the stem-cell-based therapeutic strategies in use and under development to restore sight in affected patients.
North East England Stem Cell Institute, Central Parkway, Newcastle upon Tyne NE13BZ, UK.
Sajjad
S
Ahmad
Sai
S
Kolli
Majlinda
M
Lako
Francisco
F
Figueiredo
Julie T
JT
Daniels
D000818:Animals; D002478:Cells, Cultured; D003315:Cornea / Q000473:pathology; D003316:Corneal Diseases / Q000473:pathology / Q000628:therapy*; D053595:Embryonic Stem Cells; D004847:Epithelial Cells / Q000637:transplantation; D019573:Epithelium, Corneal / Q000473:pathology; D006801:Humans; D039904:Pluripotent Stem Cells; D033581:Stem Cell Transplantation; D016896:Treatment Outcome