Progressive juvenile glomerulonephropathy in 16 related French Mastiff (Bordeaux) dogs.
BACKGROUND
Familial juvenile glomerulonephropathy (JGN) is reported in several breeds of dogs. The mode of inheritance and spectrum of pathological lesions vary among breeds. A progressive JGN was detected in a pedigree of French Mastiff (FM) dogs.


OBJECTIVE
To describe clinical, laboratory, and histopathologic findings in related FM dogs suffering from progressive JGN and to determine the mode of inheritance of this condition.


METHODS
Sixteen affected and 35 healthy related FM dogs


METHODS
FM dogs < 24 months of age and diagnosed with chronic kidney disease with evidence of proteinuria entered the study. Clinical, laboratory, histopathologic findings, and pedigree data were recorded.


RESULTS
Clinical signs were typical of progressive glomerulopathy with resultant renal failure. Increased blood urea nitrogen, creatinine and total cholesterol concentrations, and proteinuria were found in all patients. Affected dogs had abnormal kidney structure on abdominal ultrasound examination. Histopathologic examination revealed extensive cystic glomerular atrophy, glomerular hypercellularity, and capillary wall thickening without immune complex deposition when tested with immunohistochemistry or immunofluorescence. Electron microscopy did not disclose specific primary glomerular lesions. Mean age at death was 20 months and mean length of survival after diagnosis was 6 months. Both males and females from healthy parents were affected. An autosomal recessive mode of transmission is suspected, but a more complex mode of inheritance cannot be excluded.


CONCLUSIONS
Progressive familial JGN occurs in FM dogs. Characterization of the pathogenesis and mode of inheritance of this disease warrants additional study.
Lavoué
R
R
Department of Companion Animal Clinical Sciences , Faculty of Veterinary Medicine, University of Liège, Liège, Belgium. rlavoue@yahoo.fr
van der Lugt
J J
JJ
Day
M J
MJ
Georges
M
M
Busoni
V
V
Merveille
A C
AC
Poujade
A
A
Peeters
D
D
D000818:Animals; D004283:Dog Diseases / Q000235:genetics*; D004285:Dogs; D005260:Female; D020022:Genetic Predisposition to Disease; D005921:Glomerulonephritis / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D007668:Kidney / Q000473:pathology; D008297:Male; D010375:Pedigree