Genetics of obsessive-compulsive disorder.
Obsessive-compulsive disorder is a common debilitating condition affecting individuals from childhood through adult life. There is good evidence of genetic contribution to its etiology, but environmental risk factors also are likely to be involved. The condition probably has a complex pattern of inheritance. Molecular studies have identified several potentially relevant genes, but much additional research is needed to establish definitive causes of the condition.
Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Johns Hopkins Hospital, Meyer 113, 600 North Wolfe Street, Baltimore, MD 21287, USA. gnestadt@jhmi.edu
Gerald
G
Nestadt
Marco
M
Grados
Jack F
JF
Samuels
D004777:Environment; D056726:Genetic Association Studies; D008040:Genetic Linkage; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000453:epidemiology / Q000235:genetics*; D010641:Phenotype