[Progress of studies on acu-moxibustion stimulation-induced cellular transmembrane signal transduction of the target-organs].
Abundant research results have shown that multiple levels and links of cellular transmembrane signal transduction pathways in the target organs were involved in the efficacy of acupuncture. For instance, 1) various extra-cellular growth factors for initiating signal transduction by activating tyrosine protein kinase and non-receptor tyrosine kinase, 2) G protein-coupled protein kinase-second signal messengers, 3) ligands acting on intra-nuclear receptors to activate transduction pathway of nuclear transcription factors of the target genes, have been demonstrated in the favorable regulating process of acupuncture and moxibustion in different pathological animal models. In the present paper, the authors review the progress of studies on the abovementioned mechanism of acu-moxibustion underlying improving some disorders as 1) pain, cerebral ischemia, and senile dementia, 2) inflammation and tumor, and 3) myocardial ischemia. Moreover, the authors also analyze the extant problems and make a prospect on the future studies about the cellular transmembrane signal transduction pathways involving the effects of acupuncture and moxibustion.
Yi
Shou-Xiang
SX
Institute of Acu-moxibustion and Massage, Hunan University of Chinese Medicine, Key Laboratory for Researching the Correlation between Acupoints and Zangfu-organs, Changsha 410007, China. yishouxiang@yahoo.com
Peng
Yan
Y
D015670:Acupuncture Therapy; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D009071:Moxibustion; D015398:Signal Transduction