Chaperone-mediated autophagy.
Continuous renewal of intracellular components is required to preserve cellular functionality. In fact, failure to timely turnover proteins and organelles leads often to cell death and disease. Different pathways contribute to the degradation of intracellular components in lysosomes or autophagy. In this review, we focus on chaperone-mediated autophagy (CMA), a selective form of autophagy that modulates the turnover of a specific pool of soluble cytosolic proteins. Selectivity in CMA is conferred by the presence of a targeting motif in the cytosolic substrates that, upon recognition by a cytosolic chaperone, determines delivery to the lysosomal surface. Substrate proteins undergo unfolding and translocation across the lysosomal membrane before reaching the lumen, where they are rapidly degraded. Better molecular characterization of the different components of this pathway in recent years, along with the development of transgenic models with modified CMA activity and the identification of CMA dysfunction in different severe human pathologies and in aging, are all behind the recent regained interest in this catabolic pathway.
Bejarano
Eloy
E
Department of Developmental and Molecular Biology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Cuervo
Ana Maria
AM
D000375:Aging / Q000502:physiology; D000818:Animals; D017951:Antigen Presentation; D001343:Autophagy / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology; D016464:Lysosomal Storage Diseases / Q000473:pathology; D008247:Lysosomes / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000473:pathology; D018384:Oxidative Stress; D013217:Starvation / Q000473:pathology
D018832:Molecular Chaperones