Stem cell therapies for ocular surface disease.
Transparency of the cornea on the front surface of the eye is essential for vision. A variety of blinding ocular surface diseases involve the cornea. This review focusses on vision loss caused by disruption of the integrity and function of the outermost corneal layer (the epithelium) and the stem-cell-based therapeutic strategies in use and under development to restore sight in affected patients.
Ahmad
Sajjad
S
North East England Stem Cell Institute, Central Parkway, Newcastle upon Tyne NE13BZ, UK.
Kolli
Sai
S
Lako
Majlinda
M
Figueiredo
Francisco
F
Daniels
Julie T
JT
D000818:Animals; D002478:Cells, Cultured; D003315:Cornea / Q000473:pathology; D003316:Corneal Diseases / Q000473:pathology / Q000628:therapy*; D053595:Embryonic Stem Cells; D004847:Epithelial Cells / Q000637:transplantation; D019573:Epithelium, Corneal / Q000473:pathology; D006801:Humans; D039904:Pluripotent Stem Cells; D033581:Stem Cell Transplantation; D016896:Treatment Outcome