Sensors of the innate immune system: their link to rheumatic diseases.
Evidence strongly suggests that excessive or protracted signaling, or both, by cell-surface or intracellular innate immune receptors is central to the pathogenesis of most autoimmune and autoinflammatory rheumatic diseases. The initiation of aberrant innate and adaptive immune responses in autoimmune diseases can be triggered by microbes and, at times, by endogenous molecules--particularly nucleic acids and related immune complexes--under sterile conditions. By contrast, most autoinflammatory syndromes are generally dependent on germline or de novo gene mutations that cause or facilitate inflammasome assembly. The consequent production of proinflammatory cytokines, principally interferon-alpha/beta and tumor necrosis factor in autoimmune diseases, and interleukin-1beta in autoinflammatory diseases, leads to the creation of autoamplification feedback loops and chronicity of these syndromes. These findings have resulted in a critical reappraisal of pathogenetic mechanisms, and provide a basis for the development of novel diagnostic and therapeutic modalities for these diseases.
Theofilopoulos
Argyrios N
AN
Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. argyrio@scripps.edu
Gonzalez-Quintial
Rosana
R
Lawson
Brian R
BR
Koh
Yi T
YT
Stern
Michael E
ME
Kono
Dwight H
DH
Beutler
Bruce
B
Baccala
Roberto
R
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D016207:Cytokines / Q000378:metabolism; D025461:Feedback, Physiological; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D011971:Receptors, Immunologic / Q000502:physiology*; D012216:Rheumatic Diseases / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology*
D016207:Cytokines; D011971:Receptors, Immunologic