Total and antigen-specific IGE levels in umbilical cord blood.
The present study was conducted to learn whether the perinatal and environmental factors could influence the total and antigen-specific IgE levels in umbilical cord blood. Retrospective data were obtained from 173 mother-infant pairs. Total and specific (for children's food, wheat/grass and house dust mite-HDM) cord blood IgE levels were determined using the immunoassay test. The total cord blood IgE was between 0.0-23.08 IU/ml (mean 0.55 +/-2.07 IU/ml; median 0.16 IU/ml). Total IgE levels were significantly higher in boys compared with girls (OR=2.2; P=0.007), and in newborns with complicated pregnancy (OR=2.7; P=0.003). A greater number of siblings correlated with increases in the total cord blood IgE (P<0.02). We detected specific IgE in 34 newborns (40 positive tests). A long-standing contact with a cat during pregnancy decreased the specific IgE level for wheat/grass (OR=3.2; P<0.07) and for children's food (OR=5.0; P<0.04), and the contact with a dog decreased the specific-IgE for wheat/grass (OR=0.3; P<0.05). Exposure to tobacco smoke correlated with the positive specific IgE toward house dust mite (OR=4.7; P=0.005).
Department of Prevention of Envirnomental Hazards and Allergoloy, Warsaw Medical University, Warsaw, Poland. Adam.sybilski@cskmswia.pl
A J
AJ
Sybilski
A
A
Doboszynska
B
B
Samolinski
D000818:Animals; D002415:Cats; D004285:Dogs; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D012907:Smoking / Q000276:immunology
D007073:Immunoglobulin E