Triplex-stabilizing properties of parallel clamps carrying LNA derivatives at the Hoogsteen strand.
DNA Parallel clamps with a polypurine strand linked to a polypyrimidine Hoogsteen strand containing locked nucleic acids bind their corresponding polypyrimidine targets with high affinity.
Alvira
Margarita
M
Institute for Research in Biomedicine, IQAC-CSIC, CIBER-BBN Networking Centre on Bioengineering, Biomaterials and Nanomedicine, Edifici Helix, Baldiri Reixac 15, ES-08028 Barcelona, Spain.
Eritja
Ramon
R
D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*
D009841:Oligonucleotides; C477371:locked nucleic acid; D012313:RNA