Massive ingestion of cardiac drugs: toxicokinetic aspects of digoxin and sotalol during hemofiltration.
METHODS
We present the case of a 75-year-old patient admitted to the emergency department after ingesting a large amount of several cardiac drugs, among which were digoxin and sotalol. Because of renal insufficiency, cardiogenic shock, and high serum digoxin levels, the patient received continuous venovenous hemofiltration (CVVH) and digoxin-specific Fab fragments. Digoxin and the digoxin-specific Fab fragments are normally cleared by the kidneys.


METHODS
Serum-free and total digoxin and serum sotalol concentrations were monitored for several days.


RESULTS
Less than 10% of the estimated ingested dose of digoxin was cleared by CVVH within 5 days.


CONCLUSIONS
CVVH has little influence on the clearance of Fab-bound digoxin from the body. In contrast, sotalol is efficiently cleared by CVVH.
Mulder
Verena C
VC
Department of Clinical Pharmacy, Onze Lieve Vrouwe Gasthuis, Amsterdam, The Netherlands.
Oudemans-Van Straaten
Heleen M H
HM
Zandstra
Durk F
DF
Franssen
Eric J F
EJ
D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics* / Q000506:poisoning; D004077:Digoxin / Q000493:pharmacokinetics* / Q000506:poisoning; D006440:Hemofiltration / Q000379:methods*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage / Q000378:metabolism; D008297:Male; D051437:Renal Insufficiency / Q000150:complications / Q000628:therapy; D012770:Shock, Cardiogenic / Q000150:complications; D013015:Sotalol / Q000493:pharmacokinetics* / Q000506:poisoning; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D007140:Immunoglobulin Fab Fragments; C050199:digoxin antibodies Fab fragments; D004077:Digoxin; D013015:Sotalol