Light-sensitive intelligent drug delivery systems of coumarin-modified mesoporous bioactive glass.
Functionalized mesoporous bioactive glasses (MBG) with photoactive coumarin demonstrates photo-responsive dimerization resulting in reversible gate operation. Coumarin-modified MBG was used as a drug delivery carrier to investigate drug storage/release characteristics using phenanthrene as a model drug. Irradiation with UV light (>310 nm) induced photo-dimerization of the coumarin-modified MBG, which led to the pores' closing with cyclobutane dimers and trapping of the guest phenanthrene in the mesopores. However, irradiating the dimerized-coumarin-modified MBG with shorter wavelength UV light (approximately 250 nm) regenerates the coumarin monomer derivative by the photo-cleavage of cyclobutane dimers, such that trapped guest molecules are released from the mesopores. The structural, morphological, textural and optical properties are well characterized by X-ray diffraction, transmission electron microscopy, N(2) adsorption/desorption, and UV-visible spectroscopy. The results reveal that the MBG exhibits the typical ordered characteristics of the hexagonal mesostructure. The system demonstrates great potential in light-sensitive intelligent drug delivery systems and disease therapy fields.
Lin
H-M
HM
Institute of Bioscience and Biotechnology, National Taiwan Ocean University, Keelung, Taiwan 20224, Republic of China. hmlin@mail.ntou.edu.tw
Wang
W-K
WK
Hsiung
P-A
PA
Shyu
S-G
SG
D000327:Adsorption / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D003692:Delayed-Action Preparations / Q000494:pharmacology; D019281:Dimerization; D016503:Drug Delivery Systems / Q000379:methods*; D005898:Glass / Q000737:chemistry*; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D046529:Microscopy, Electron, Transmission; D009584:Nitrogen / Q000737:chemistry; D016062:Porosity / Q000187:drug effects; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D014961:X-Ray Diffraction
D003374:Coumarins; D003692:Delayed-Action Preparations; C030123:coumarin; D009584:Nitrogen