[Association of glucocorticoid receptor gene polymorphism with myasthenia gravis].
OBJECTIVE
To investigate the association of two glucocorticoid receptor (GR) polymorphisms (BclI, ER22/23EK) with Myasthenia Gravis (MG).


METHODS
The genotypes of GR in 61 MG patients (MGG) and 57 age and gender-matched healthy controls (HCG) were determined by polymerase chain reaction and nucleotide sequence determination.


RESULTS
The frequencies of three genotypes (GG, CG, CC) in BclIwere 3.3%, 34.4%, 62.3% in MGG and 3.5%, 38.6%, 57.9%in HCG respectively. The difference in the distribution of genotypes between MGG and HCG was statistically insignificant (P = 0.887). The frequencies of G and C allele were 20.5% vs 79.5 %in MGG, and 22.8% vs 77.2% in HCG. The difference in the distribution of alleles between MGG and HCG was statistically insignificant (P = 0.968). The genotype frequencies in two groups were both in Hardy-Weinberg equilibrium (P > 0.05). The genotypes of ER22/23EK in MGG and HCG were all GG and no mutation was detected.


CONCLUSIONS
BclI and ER22/23EK polymorphisms of GR have no definite relationship with the risk of MG.
Department of Neurology, Beijing Hospital, Ministry of Health, China.
Li-li
LL
Wang
Yan-chen
YC
Xie
Shi-fang
SF
Hou
Kai
K
Feng
Jian
J
Yin
Xian-hao
XH
Xu
Zun-bo
ZB
Li
Ying-peng
YP
Wang
Ting
T
Xiong
Jian-jun
JJ
Liu
Ding-guo
DG
Shen
D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011965:Receptors, Glucocorticoid / Q000235:genetics*
C497713:NR3C1 protein, human; D011965:Receptors, Glucocorticoid