FOXP3 and GARP (LRRC32): the master and its minion.
The transcription factor FOXP3 is essential for the development and function of CD4+CD25hiFOXP3+ regulatory T (T(reg)) cells, but also expressed in activated human helper T cells without acquisition of a regulatory phenotype. This comment focuses on glycoprotein-A repetitions predominant (GARP or LRRC32) recently identified as specific marker of activated human T(reg) cells, which may provide the missing link toward a better molecular definition of the regulatory phenotype.
Institute for Microbiology, Immunology and Hygiene, Städtisches Klinikum Braunschweig gGmbH, Braunschweig, Germany. m.probst-kepper@klinikum-braunschweig.de
Michael
M
Probst-Kepper
Jan
J
Buer
D000818:Animals; D051858:Forkhead Transcription Factors / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D039942:Neuropilin-1 / Q000737:chemistry / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism
D051858:Forkhead Transcription Factors; D008565:Membrane Proteins; D016212:Transforming Growth Factor beta; D039942:Neuropilin-1