Synthetic polyacrylate polymers as particulate intranasal vaccine delivery systems for the induction of mucosal immune response.
The nasal route as a site of vaccine delivery for both local and systemic effect is currently of considerable interest. The administration of vaccines to mucosal surfaces such as the nasopharynx associated lymphoid tissues confers many advantages since the nasal mucosa is a primary site through which most inhaled antigens are encountered. However, the success of intranasally delivered mucosal vaccines is limited by lack of effective vaccine formulations or delivery systems suitable for use in humans. This review provides a brief overview of the mucosal immune system at the nasal surface, enhancement techniques for induction of mucosal immune response after intranasal administration of particulate systems and an explanation of the inherent properties of polyacrylate polymer-based particulate systems that may facilitate mucosal immune responses.
School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia. i.toth@uq.edu.au.
Mehfuz
M
Zaman
Pavla
P
Simerska
Istvan
I
Toth
D000180:Acrylic Resins / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D000281:Administration, Intranasal; D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D018928:Immunity, Mucosal / Q000187:drug effects*; D018448:Models, Immunological; D009297:Nasal Mucosa / Q000187:drug effects / Q000276:immunology*; D052638:Particulate Matter / Q000008:administration & dosage* / Q000493:pharmacokinetics; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D014014:Tissue Adhesives / Q000008:administration & dosage / Q000737:chemistry; D014612:Vaccines / Q000008:administration & dosage*
D000180:Acrylic Resins; D000941:Antigens; D052638:Particulate Matter; D011108:Polymers; D014014:Tissue Adhesives; D014612:Vaccines; C006903:carbopol 940