Exophytic renal masses: angular interface with renal parenchyma for distinguishing benign from malignant lesions at MR imaging.
OBJECTIVE
To retrospectively determine whether benign exophytic renal masses can be distinguished from renal cell carcinoma (RCC) on the basis of angular interface at single-shot fast spin-echo (SE) T2-weighted magnetic resonance (MR) imaging.


METHODS
This retrospective study was compliant with HIPAA and was approved by the institutional review board. Patient informed consent was waived. A total of 162 exophytic (2 cm or greater) renal masses in 152 patients (103 men, 49 women; mean age, 58 years; age range, 23-85 years) were included. Two radiologists independently recorded the mass size and angular interface on single-shot fast SE T2-weighted MR images. Surgical pathologic report and MR follow-up were used as reference standards. Logistic regression analysis was used to examine the usefulness of these variables for differentiating benign masses from RCCs. Diagnostic performance was analyzed by comparing values for area under receiver operating characteristic curve (A(z)). Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of angular interface for diagnosing benign masses were calculated. Reader agreement was assessed with kappa-weighted statistics and intraclass correlation coefficients (ICCs).


RESULTS
Of 162 masses, 65 were benign, and 97 were RCCs. The sensitivity, specificity, PPV, NPV, and A(z) of angular interface for diagnosing benign masses were 78%, 100%, 100%, 87%, and 0.813, respectively. Angular interface (P < .001) was a significant predictor of benign renal mass but mass size (P = .66) was not. There was almost perfect interobserver agreement for mass size (ICC = 0.96) and angular interface (kappa = 0.91).


CONCLUSIONS
The presence of an angular interface with the renal parenchyma at single-shot fast SE T2-weighted MR imaging is a strong predictor of benignity in an exophytic renal mass 2 cm or greater in diameter with high specificity and diagnostic accuracy.
Verma
Sachit K
SK
Department of Radiology, Thomas Jefferson University Hospital, 132 S 10th St, Philadelphia, PA 19107, USA. medskv@yahoo.com
Mitchell
Donald G
DG
Yang
Roberta
R
Roth
Christopher G
CG
O'Kane
Patrick
P
Verma
Manisha
M
Parker
Laurence
L
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000473:pathology; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000473:pathology; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000473:pathology; D016015:Logistic Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
D003287:Contrast Media; D019786:Gadolinium DTPA