Comparison of genotypic resistance mutations in treatment-naive HIV type 1-infected patients in Korea and China.
Seventy-six treatment-naive human immunodeficiency virus (HIV)-1-infected patients were recruited from Korea and China to evaluate transmitted drug resistance (TDR). Although no major TDR was observed within the study population, some resistance-associated mutations in the reverse transcriptase region were observed (V118I 9.2%, V179D 7.9%). The frequencies of resistance-associated mutations in NNRTI (V179D) and PI minor mutations were higher in Korean patients compared with Chinese patients (13.6% vs. 0%, 45.5% vs. 12.5%, p < 0.05). Although unique clustering was observed in phylogenetic analyses according to geographic sources, cautious monitoring is recommended due to increasing TDR reports in this area where the population shares close geographic and cultural aspects.
Department of Internal Medicine, Yonsei University College of Medicine , Seoul, Korea.
Bum Sik
BS
Chin
Jun Yong
JY
Choi
Yang
Y
Han
Jiqiu
J
Kuang
Yanling
Y
Li
Sang Hoon
SH
Han
Heekyoung
H
Choi
Yun Tae
YT
Chae
Sung Joon
SJ
Jin
Ji-Hyeon
JH
Baek
Young-Soun
YS
Lim
Chang Oh
CO
Kim
Young Goo
YG
Song
Dongeun
D
Yong
Taisheng
T
Li
June Myung
JM
Kim
D000328:Adult; D002681:China; D016000:Cluster Analysis; D024882:Drug Resistance, Viral; D005260:Female; D005843:Geography; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D007723:Korea; D008297:Male; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D010802:Phylogeny; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D014764:Viral Proteins / Q000235:genetics*; D055815:Young Adult
D014764:Viral Proteins