[Concentration of selected microelements in blood serum of rats exposed to the action of psilocin and phenylethylamine].
Natural hallucinogens (including Psilocybe mushrooms) became popular in Europe since the nineties. They have been in the focus of clinicians interest for years because of their biological effects. Mechanism of action of these hallucinogens, both Psilocin and Psilocibin, is based on the physiological structure similarity to human neurotransmitters as serotonin and catecholamines. One of the previous works indicated the possibility of the cardiotoxic action of the Psilocibin mushroom, effecting in anoxemic heart laesure. To verify the hypothesis of the Psilocibin-like myocardial damage wide experimental programme was designed. In the present work we introduce some results concerning magnesium, calcium, natrium, kalium and chloride plasma concentration in rats subjected subchronicly to psilocin and phenylethylamine. Basing on the obtained results, it can be stated that subchronic intoxication with natural hallucinogens may disturb magnesium balance without significantly effecting other microelements.
Zakład Medycyny Sadowej Pomorskiej Akademii Medycznej w Szczecinie, al. Powstańców Wlkp. 72, 70-111 Szczecin.
Sławomir
S
Majdanik
Krzysztof
K
Borowiak
Maria
M
Brzezńska
Anna
A
Machoy-Mokrzyńska
D000818:Animals; D002118:Calcium / Q000097:blood; D002712:Chlorides / Q000097:blood; D006213:Hallucinogens / Q000633:toxicity*; D008274:Magnesium / Q000097:blood*; D008297:Male; D010627:Phenethylamines / Q000633:toxicity*; D011562:Psilocybin / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000097:blood; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D002712:Chlorides; D006213:Hallucinogens; D010627:Phenethylamines; D011562:Psilocybin; D012964:Sodium; C009105:psilocin; D008274:Magnesium; D002118:Calcium