Potential atrial arrhythmogenicity of adipocytes: implications for the genesis of atrial fibrillation.
Atrial fibrillation is the most common sustained cardiac arrhythmia. Obesity and metabolic syndrome are independent risk factors for atrial fibrillation, and epicardial adipose tissues are highly associated with the genesis of atrial fibrillation, compared to visceral fat. Adipocytes can produce inflammatory cytokines and adipocytokines, which may enhance inflammation and oxidative stress in patients with obesity or metabolic syndrome. Moreover, it is possible that local interactions between epicardial adipose tissue and the adjacent myocardium can directly produce electrical or structural remodelings in the atrium. Taken together, we hypothesized that epicardial adipocytes contain distinctive arrhythmogenicity through increases in inflammatory cytokines, adipocytokines, and adipocyte-cardiomyocyte interactions to induce atrial fibrillation.
Cardiovascular Center, Far Eastern Memorial Hospital, Taipei, Taiwan.
Yung-Kuo
YK
Lin
Yi-Jen
YJ
Chen
Shih-Ann
SA
Chen
D017667:Adipocytes / Q000502:physiology*; D054392:Adipokines / Q000502:physiology; D001281:Atrial Fibrillation / Q000209:etiology* / Q000503:physiopathology; D055724:Electrophysiological Phenomena; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology; D024821:Metabolic Syndrome / Q000150:complications; D008955:Models, Cardiovascular; D032383:Myocytes, Cardiac / Q000502:physiology; D009765:Obesity / Q000150:complications; D010496:Pericardium / Q000503:physiopathology; D012307:Risk Factors
D054392:Adipokines; D018836:Inflammation Mediators