Persistence of long-term memory storage: new insights into its molecular signatures in the hippocampus and related structures.
Although much is known about long-term memory (LTM) consolidation, what puts the "long" in LTM is the exclusive feature of persisting over time. However, until recently the molecular mechanisms underneath memory persistence had never been properly studied. In rats, the protein translation inhibitor anisomycin impaired memory persistence when injected into the dorsal hippocampus 12 h after inhibitory avoidance (IA) training without affecting memory formation. Here, we also show learning-induced changes in hippocampal c-Fos, Homer 1a, Akt, CamKIIα, and ERK2 levels around 18-24 h after IA training. Thus, memory persistence is associated with a late phase of plasticity-related protein synthesis in the hippocampus.
Instituto de Biología Celular y Neurociencias, Facultad de Medicina, UBA, Paraguay 2155 3rd floor, 1121, Buenos Aires, Argentina.
Pedro
P
Bekinschtein
Cynthia
C
Katche
Leandro
L
Slipczuk
Carolina
C
Gonzalez
Guido
G
Dorman
Martín
M
Cammarota
Iván
I
Izquierdo
Jorge H
JH
Medina
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology; D001923:Brain Chemistry / Q000502:physiology*; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000737:chemistry / Q000502:physiology; D006624:Hippocampus / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D057567:Memory, Long-Term / Q000502:physiology*; D019950:Mitogen-Activated Protein Kinase 1 / Q000737:chemistry / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D014176:Protein Biosynthesis / Q000502:physiology*; D013997:Time Factors
D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; C535150:MAPK1 protein, human; D019950:Mitogen-Activated Protein Kinase 1