The influence of fluid flow on modeling quorum sensing in bacterial biofilms.
In this paper, we study quorum sensing in Pseudomonas aeruginosa biofilms. Quorum sensing is a process where bacteria monitor their population density through the release of extra-cellular signalling molecules. The presence of these molecules affects gene modulation leading to changes in behaviour such as the release of virulence factors. Here, we use numerical methods to approximate a 2-D model of quorum sensing. It is observed that the shape of the biofilm can have a profound effect on the onset of quorum sensing. This has serious repercussions for experimental observations since biofilms of the same biomass but different shapes can produce quite different results.
Centre for Mathematical Biology, University of Oxford, UK. vaughan@maths.ox.ac.uk
Benjamin L
BL
Vaughan
Bryan G
BG
Smith
David L
DL
Chopp
D054742:Acyl-Butyrolactones / Q000378:metabolism; D000465:Algorithms; D018407:Bacterial Physiological Phenomena; D018441:Biofilms; D018533:Biomass; D003198:Computer Simulation; D004058:Diffusion; D008954:Models, Biological; D011156:Population Density; D011550:Pseudomonas aeruginosa / Q000502:physiology; D053038:Quorum Sensing / Q000502:physiology*; D012212:Rheology
D054742:Acyl-Butyrolactones