In vitro model of cartilage degradation.
This 14-day model of cartilage breakdown involves stimulation of bovine nasal cartilage with a combination of interleukin-1 and oncostatin M. Media is harvested on days 7 and 14 and the conditioned media and remaining cartilage at day 14 assayed for the levels of proteoglycan and collagen fragments using biochemical assays.
Musculoskeletal Research Group, Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
Wang
W
Hui
Tim E
TE
Cawston
D000818:Animals; D001681:Biological Assay / Q000379:methods*; D002356:Cartilage / Q000378:metabolism*; D002417:Cattle; D003094:Collagen / Q000378:metabolism; D004210:Dissection; D008954:Models, Biological; D011509:Proteoglycans / Q000378:metabolism; D046509:Tissue Culture Techniques
D011509:Proteoglycans; D003094:Collagen