Regulation of ionotropic glutamate receptors by their auxiliary subunits.
Glutamate receptors are major excitatory receptors in the brain. Recent findings have established auxiliary subunits of glutamate receptors as critical modulators of synaptic transmission, synaptic plasticity, and neurological disorder. The elucidation of the molecular rules governing glutamate receptors and subunits will improve our understanding of synapses and of neural-circuit regulation in the brain.
Program in Cellular Neuroscience, Neurodegeneration and Repair, Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut, USA. Susumu.Tomita@yale.edu
Susumu
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Tomita
D000818:Animals; D006801:Humans; D015640:Ion Channel Gating; D009422:Nervous System Diseases / Q000378:metabolism / Q000503:physiopathology; D009473:Neuronal Plasticity; D009474:Neurons / Q000378:metabolism*; D011487:Protein Conformation; D021122:Protein Subunits; D021381:Protein Transport; D018091:Receptors, AMPA / Q000378:metabolism; D017470:Receptors, Glutamate / Q000737:chemistry / Q000378:metabolism*; D013329:Structure-Activity Relationship; D009435:Synaptic Transmission
D021122:Protein Subunits; D018091:Receptors, AMPA; D017470:Receptors, Glutamate; C492973:alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid subtype glutamate receptor, human