Incidence of polycystic ovaries and androgen serum levels in women with borderline personality disorder.
Obesity, increased visceral fat and disturbed glucose metabolism have been found in borderline personality disorder (BPD) patients. These conditions are often associated with disturbed androgen metabolism. Elevated androgens in women are related to polycystic ovaries (PCO) and might have an impact on psychopathology. Thus, higher prevalence of PCO and elevated androgen levels are suspected in BPD. In the study, we examined 31 BPD patients and 30 healthy controls ultrasonographically for PCO and measured their serum levels of androgens and interacting hormones. Furthermore, influence on psychopathology of free testosterone (FT) serum level was assessed. PCO was significantly more prevalent in BPD patients (30.4%) compared to healthy controls (6.9%). Testosterone, FT, androstenedione (A), and 17alpha-hydroxyprogesterone (17-OHP) were significantly elevated in the BPD group independently of BMI. FT serum level significantly correlated with depressive symptoms. In summary, our data suggest a disturbed androgen metabolism in BPD patients.
Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Department of Psychiatry, Berlin, Germany. stefan.roepke@charite.de
Stefan
S
Roepke
Andreas
A
Ziegenhorn
Julia
J
Kronsbein
Angela
A
Merkl
Scharif
S
Bahri
Julia
J
Lange
Horst
H
Lübbert
Ulrich
U
Schweiger
Isabella
I
Heuser
Claas-H
CH
Lammers
D019326:17-alpha-Hydroxyprogesterone / Q000097:blood*; D000328:Adult; D000728:Androgens / Q000097:blood*; D015992:Body Mass Index; D001883:Borderline Personality Disorder / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D016022:Case-Control Studies; D015897:Comorbidity; D003863:Depression / Q000097:blood / Q000523:psychology; D005260:Female; D006801:Humans; D015994:Incidence; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology; D012307:Risk Factors; D013739:Testosterone / Q000097:blood*
D000728:Androgens; D013739:Testosterone; D019326:17-alpha-Hydroxyprogesterone