[CD5-positive B-cell prolymphocytic leukemia].
CD5 is a T-cell marker that is expressed in mature B cell malignancies and other B cell chronic lymphoproliferative disorders, but the biologic function of CD5 is unknown. We report a 68-year-old woman with B-cell prolymphocytic leukemia (B-PLL) expressing CD5 antigen. On admission, jaundice and hepatosplenomegaly were noted. Hematological examination demonstrated a platelet count of 2.8 x 10(4)/microl and a white blood cell count of 19,900/microl with 69% PLL cells. Surface marker analysis of the PLL cells was positive for CD5, CD19, CD20, sIgM, and was negative for CD23, and cyclin D1 was negative in immunostaining.
Inoue
Tetsuya
T
Department of Hematology, Social Insurance Shiga Hospital.
Yoshida
Masaaki
M
Oowashi
Kazuyoshi
K
Yoshida
Tadao
T
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D018956:CD5 Antigens / Q000097:blood*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D054403:Leukemia, Prolymphocytic, B-Cell / Q000097:blood* / Q000175:diagnosis*; D007958:Leukocyte Count; D010976:Platelet Count
D014408:Biomarkers, Tumor; D018956:CD5 Antigens