Clinical stain removal efficacy of two dentifrices after one and two weeks of use.
OBJECTIVE
This investigation evaluated extrinsic stain removal efficacy after brushing for one and two weeks with a commercially available fluoride dentifrice relative to Colgate Total Advanced Clean, a new dentifrice formulated with dual-phase silica.


METHODS
At the baseline visit, one-hundred and forty-four adult subjects were stratified by Lobene Stain Index scores and randomized to two treatment groups using either Total Advanced Clean dentifrice (0.3% triclosan, 2% copolymer, dual phase silica) or a commercially available fluoride dentifrice, and instructed to brush twice daily. Tooth stain evaluations were conducted on stain area, stain intensity, and a composite score of both, after one and two weeks of dentifrice use.


RESULTS
Baseline scores demonstrated no significant differences between the two treatment groups for all evaluated stain parameters (p > 0.05). At both the one- and two-week post-use evaluations, subjects brushing with Total Advanced Clean demonstrated significant reductions for all stain parameters versus the control (p < 0.05). The Total Advanced Clean group demonstrated mean reductions in stain intensity of 0.37 and 0.74 at the one- and two-week evaluations, respectively, versus the control group. Corresponding mean reductions in stain area for the Total Advanced Clean group versus the control were 0.12 and 0.24 at the one- and two-week evaluations, respectively. The two post-use evaluations also demonstrated significant reductions in stain composite scores for the subjects assigned Total Advanced Clean (p < 0.0001).


CONCLUSIONS
In comparison to the control dentifrice, the results demonstrated significantly more stain removal following the use of Total Advanced Clean at each recall visit. Subjects assigned Total Advanced Clean demonstrated continued reductions in stains from baseline to one week, and from one week to two weeks.
Colgate-Palmolive Technology Center, Piscataway, NJ, USA. Prem_Sreenivasan@colpal.com
P
P
Sreenivasan
W
W
DeVizio
K V V
KV
Prasad
G
G
Rajesh
R
R
Kalyanpur
C
C
Bhasker Rao
D000293:Adolescent; D000328:Adult; D000368:Aged; D002327:Cariostatic Agents; D045424:Complex Mixtures / Q000737:chemistry / Q000627:therapeutic use; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D005459:Fluorides / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D012824:Silicic Acid; D012822:Silicon Dioxide / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000627:therapeutic use; D014075:Tooth Discoloration / Q000188:drug therapy*; D014100:Toothpastes; D014260:Triclosan / Q000737:chemistry / Q000627:therapeutic use; D055815:Young Adult
D002327:Cariostatic Agents; D045424:Complex Mixtures; D003802:Dentifrices; D014100:Toothpastes; C546060:hydrated silica gel-based toothpaste; D012824:Silicic Acid; D014260:Triclosan; D012822:Silicon Dioxide; D012969:Sodium Fluoride; D005459:Fluorides