A new optical label-free biosensing platform based on a metal-insulator-metal structure.
A new label-free biosensing platform is proposed based on a metal-insulator-metal (MIM) structure. This platform allows us to perform biosensing by a simple reflectivity measurement at normal incidence illumination without using any bulky optical setup. Theoretical calculation was made to find optimized MIM structural parameters, and experimental results on the label-free biosensing using the MIM platform are presented. This platform has greater sensitivity and mass resolution with respect to the anomalous reflection method, which is a label-free biosensing platform previously proposed by us. Hence, it is suitable for high throughput analysis of biomolecular detection in a microarray format.
Syahir
Amir
A
Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226-8501, Japan.
Mihara
Hisakazu
H
Kajikawa
Kotaro
K
D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D006046:Gold / Q000737:chemistry; D008567:Membranes, Artificial; D008670:Metals
D008567:Membranes, Artificial; D008670:Metals; D006046:Gold