Effects of apolipoprotein E-epsilon4 and -epsilon2 in amnestic mild cognitive impairment and dementia in Shanghai: SCOBHI-P.
OBJECTIVE
To determine apolipoprotein E (APOE)-epsilon4 and -epsilon2 frequencies and risk of mild cognitive impairment (MCI) and dementia in Shanghai, China.


METHODS
A total of 34 MCI and 34 dementia cases were recruited from an urban Memory Disorders Clinic and 32 controls were recruited from a residential community served by the clinic. Apolipoprotein E was genotyped using standard methods.


RESULTS
Among controls, frequencies were epsilon2, 0.11; epsilon3, 0.84; and epsilon4, 0.05; among MCI, 0.05, 0.77, and 0.18; and for dementia, 0.02, 0.84, and 0.15, respectively. In education-adjusted models, the odds ratio (OR) = 5.6 for dementia (95% CI = 1.09-29.3) and 4.7 for MCI (95% CI = 0.90-25.2) associated with any epsilon4 allele. The epsilon2 allele was inversely associated with dementia (OR = 0.12, 95% CI = 0.013-0.997) and MCI (OR = 0.38, 95% CI = 0.08-1.61).


CONCLUSIONS
APOE-epsilon4 increases and -epsilon2 decreases the risk of dementia vs normal cognition. Similar trends were observed for amnestic mild cognitive impairment (aMCI).
Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612, USA. aborenst@health.usf.edu
Amy R
AR
Borenstein
James A
JA
Mortimer
Ding Ding
Gerard D
GD
Schellenberg
Charles
C
DeCarli
Qianhua Zhao
Cathleen
C
Copenhaver
Qihao Guo
Shugang Chu
Douglas
D
Galasko
David P
DP
Salmon
Qi Dai
Yougui Wu
Ronald
R
Petersen
Zhen Hong
D000368:Aged; D000647:Amnesia / Q000175:diagnosis / Q000235:genetics*; D053329:Apolipoprotein E2 / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics*; D002391:Catchment Area, Health; D002681:China / Q000453:epidemiology; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics*; D003704:Dementia / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012720:Severity of Illness Index
D053329:Apolipoprotein E2; D053327:Apolipoprotein E4