The neurobiological substrates of behavioral manifestations during temporal lobe seizures: a neuroethological and ictal SPECT correlation study.
Ictal behavior coupled with SPECT findings during 28 seizures in patients with temporal lobe epilepsy (TLE) with unilateral hippocampal sclerosis (13 left; 15 right) was displayed as flowcharts from right-sided (RTLE) plus left-sided (LTLE) seizures. Ictal SPECT was classified blind to neuroethology. Behaviors were categorized as ipsilateral to the epileptogenic zone (IL), contralateral to the epileptogenic zone (CL), or bilateral. SPECT intensity and region were categorized as IL or CL to the epileptogenic zone. All patients developed automatisms and had hyperperfusion in their temporal lobes. Patients' verbal responses to questions had statistical interactions in RTLE but not in LTLE sum. Most CL dystonic posturing was correlated to IL basal ganglia hyperperfusion. Basal ganglia activation occurred in seizures without dystonic posturing and CL manual automatisms, and lack of IL dystonic posturing and the presence of CL cerebellar hemispheric hyperperfusion were also observed. Coupling of neuroethology and SPECT findings reliably evaluates ictal behavior and functionality of associated brain areas.
Laboratory of Neurophysiology and Experimental Neuroethology, Department of Physiology, Ribeirão Preto School of Medicine, University of São Paulo, USP, Ribeirão Preto, Brazil.
Poliana
P
Bertti
Maria Luiza Cleto
ML
Dal-Cól
Lauro
L
Wichert-Ana
Mery
M
Kato
Vera Cristina
VC
Terra
José Antônio Cortes
JA
de Oliveira
Tonicarlo Rodrigues
TR
Velasco
Américo Ceiki
AC
Sakamoto
Norberto
N
Garcia-Cairasco
D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000473:pathology; D001519:Behavior / Q000502:physiology*; D001931:Brain Mapping; D002560:Cerebrovascular Circulation / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009446:Neurobiology / Q000379:methods*; D012189:Retrospective Studies; D012598:Sclerosis / Q000209:etiology / Q000473:pathology; D013223:Statistics as Topic; D015899:Tomography, Emission-Computed, Single-Photon; D014741:Video Recording / Q000379:methods