Opportunities and risk factors for premalignant and malignant transformation of endometrial polyps: management strategies.
OBJECTIVE
To estimate the prevalence of benign, premalignant, and malignant endometrial polyps and the associated clinical risk factors for premalignant and malignant endometrial polyps.


METHODS
Retrospective study (Canadian Classification II-3).


METHODS
Teaching hospital.


METHODS
Seven hundred sixty-six patients with endometrial polyps.


METHODS
Hysteroscopic removal of endometrial polyps.


RESULTS
Patient clinical data were identified and analyzed. Frequency of premalignant and malignant histopathologic features in endometrial polyps was calculated. Clinical risk factors for premalignant and malignant endometrial polyps were analyzed. Endometrial polyps were histologically benign in most patients (96.21%). Hyperplasia with atypia in a polyp (premalignant polyp) was found in 3.26% of patients, and endometrial carcinoma in a polyp (malignant polyp) was detected in only 0.52% of patients. Independent variables that were significantly related to premalignant and malignant polyps (all p<.05) in a binary logistic regression analysis included polyp diameter (odds ratio [OR], 2.93; 95% confidence interval [CI], 1.191-7.20), menopause status (OR, 4.85; 95% CI, 2.09-11.27), and abnormal uterine bleeding (OR, 3.97; 95% CI, 1.71-9.18).


CONCLUSIONS
Polyp diameter larger than 1.0cm, menopause status, and abnormal uterine bleeding may increase the risk of premalignant and malignant endometrial polyps.
Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Jian-Hua
JH
Wang
Jin
J
Zhao
Jun
J
Lin
D000328:Adult; D002681:China / Q000453:epidemiology; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D008875:Middle Aged; D011127:Polyps / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D011230:Precancerous Conditions / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D015995:Prevalence; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D014591:Uterine Diseases / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery