Age-related changes in niche cells influence hematopoietic stem cell function.
In a recent issue of Nature, Mayack et al. (2010) use young and old parabiotic mice to show that systemic signals from the young parabiont rejuvenate hematopoietic stem cell function via the microenvironmental niche.
Department of Internal Medicine and Markey Cancer Center, University of Kentucky, 800 Rose Street, Lexington, KY 40536, USA.
Erin J
EJ
Oakley
Gary
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Van Zant