An evaluation of "I, Pancreas" algorithm performance in silico.
BACKGROUND
The objective of this study was to investigate the performance of a newly proposed insulin titrating algorithm to achieve tight glycemic control in the critically ill.


METHODS
A simulation environment with 10 critically ill virtual subjects was employed to evaluate the "I, Pancreas" algorithm proposed by Braithwaite et al. and described in an article in this issue of Journal of Diabetes Science and Technology. The algorithm was coded in MATLAB and was "plugged in" to a simulation environment to provide glucose control in a 48-hour-long simulated study.


RESULTS
Mean blood glucose was 6.5 +/- 0.4 mmol/liter (118 +/- 7.8 mg/dl), percentage of time spent in the target glucose range was 38% (32-44%), and the hyperglycemic index was 0.6 (0.4 -1.0) mmol/liter [11.1 (7.7-18.1) mg/dl]. A single episode of mild hypoglycemia at 3.8 mmol/liter (69 mg/dl) was observed during 480 hours of glucose control.


CONCLUSIONS
In this initial in silico evaluation, the "I, Pancreas" algorithm provided a safe control of glucose in the simulated study and achieved tight glycemic control 38% of the time.
Wilinska
Malgorzata E
ME
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, United Kingdom. mew37@medschl.cam.ac.uk
Nodale
Marianna
M
D000465:Algorithms; D001786:Blood Glucose / Q000187:drug effects*; D003198:Computer Simulation; D016638:Critical Illness; D003920:Diabetes Mellitus / Q000188:drug therapy; D006801:Humans; D007328:Insulin / Q000008:administration & dosage* / Q000627:therapeutic use
D001786:Blood Glucose; D007328:Insulin