New and simple synthesis of acid azides, ureas and carbamates from carboxylic acids: application of peptide coupling agents EDC and HBTU.
Conversion of carboxylic acids into acid azides using peptide coupling agents, EDC and HBTU is described. The procedure is efficient, practical and applicable to a diverse range of carboxylic acids including N-protected amino acids. Using the same reagents, one-pot synthesis of ureas, dipeptidyl urea esters and carbamates from acids has also been achieved.
Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr. B. R. Ambedkar Veedhi, Bangalore - 560 001, India. sureshbabuvommina@rediffmail.com
Vommina V
VV
Sureshbabu
H S
HS
Lalithamba
N
N
Narendra
H P
HP
Hemantha
D001386:Azides / Q000138:chemical synthesis* / Q000737:chemistry; D002219:Carbamates / Q000138:chemical synthesis / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D014508:Urea / Q000138:chemical synthesis* / Q000737:chemistry
D001386:Azides; D002219:Carbamates; D002264:Carboxylic Acids; D010455:Peptides; D014508:Urea