Inhibition of cell proliferation, adhesion, and invasion with an anti-L1-cell adhesion molecule monoclonal antibody in an in vitro endometriosis model.
The use of anti-L1-cell adhesion molecule monoclonal antibodies (anti-L1CAM-mAb) in an endometriosis epithelial cell line Z12 led to a statistically significant decrease in cell proliferation and cell invasion and to an inhibition of the adhesion compared with unspecific IgG-Ab treated and untreated cells. Because it increases the cell invasion and adhesion which consequently aggravates the disease, L1 could possibly promote endometriosis development; thus, further studies should evaluate the possible use of anti-L1-mAb in an animal endometriosis model.
Agic
Admir
A
Department of Obstetrics and Gynecology, University of Schleswig-Holstein, Campus Luebeck, Luebeck, Germany.
von Wussow
Ursula
U
Starzinski-Powitz
Anna
A
Diedrich
Klaus
K
Altevogt
Peter
P
Hornung
Daniela
D
D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D015536:Down-Regulation / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004715:Endometriosis / Q000473:pathology*; D005260:Female; D006801:Humans; D008954:Models, Biological; D039842:Neural Cell Adhesion Molecule L1 / Q000037:antagonists & inhibitors / Q000276:immunology*; D010532:Peritoneal Diseases / Q000473:pathology*
D000911:Antibodies, Monoclonal; D039842:Neural Cell Adhesion Molecule L1