[Correlation between single nucleotide polymorphisms and hematological malignancies].
Single nucleotide polymorphisms (SNPs) are the 3rd generation of molecular genetic markers of human populations.SNPs determine the functional units of genes and the inherent characteristics of genetic variation, and reflect the individual phenotype, disease susceptibility and differences of response to drug and environmental factors. Hematological malignancy is a multi-gene genetic diseases, and involve in the role of multigenic susceptible genes. This review intends to introduce the single nucleotide polymorphisms and their relevant progress of research on hematologic malignancies, including the SNP of carcinogen-metabolizing enzymes genes, the SNP of DNA repair genes, the SNP of oncogenes and anti-oncogene genes, the SNP of drug-metabolizing enzyme genes and so on.
Department of Hematology, Zhongda Hospital, Southeast University Clinical Medical College, Nanjing 210009, Jiangsu Province, China.
Pei-Pei
PP
Xu
Bao-An
BA
Chen
Shu
S
Cheng
D002874:Chromosome Mapping; D020022:Genetic Predisposition to Disease; D019337:Hematologic Neoplasms / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide