A practical chemo-enzymatic synthesis of homochiral bicyclo[2.2.2]octane-2,5-dione.
A practical synthetic route for the preparation of chiral bicyclo[2.2.2]octane-2,5-dione, the precursor of useful chiral diene ligands, was realized via Diels-Alder reaction and resolution of an enol acetate derivative by immobilized lipases.
Luo
Yunfei
Y
Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, UK.
Carnell
Andrew J
AJ
D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D009795:Octanes / Q000737:chemistry*; D013237:Stereoisomerism
D001643:Bridged Bicyclo Compounds; D009795:Octanes; C521607:bicyclo(2.2.2)octane-2,5-dione; C026728:octane