Validation of the MOS-HIV as a measure of health-related quality of life in persons living with HIV and liver disease.
BACKGROUND
Management of human immunodeficiency virus (HIV) infection with potent antiretroviral medication has transformed HIV into a chronic condition and has shifted much of the burden of disease to co-morbid conditions such as liver disease (LD). LD alone has been shown to have a significant effect on one's health-related quality of life (HRQOL). Clinical evidence suggests that the growing number of persons living with HIV+LD may have a poorer HRQOL than persons with HIV without LD. To date, the widely accepted instrument to assess HRQOL, Medical Outcomes Study-HIV Health Survey (MOS-HIV), has not been evaluated for reliability and validity in a population of HIV-infected persons with LD.


METHODS
HRQOL was prospectively assessed using the MOS-HIV in a sample of 532 HIV-infected adults on antiretroviral therapy (n=305 HIV and n=227 HIV+LD). In addition, participants completed standardized questionnaires of sociodemographics and co-morbid conditions.


RESULTS
The psychometric properties of the MOS-HIV were supported by testing reliability and construct, convergent, discriminative, and predictive validity. The MOS-HIV discriminated between those persons living with HIV with and without LD on the basis of the physical function subscale scores (p=0.018).


CONCLUSIONS
This study found the MOS-HIV valid and reliable instrument in persons with HIV+LD.
Biobehavioral Unit, Symptom Management Branch, National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA. hendersw@mail.nih.gov
Wendy A
WA
Henderson
Elizabeth A
EA
Schlenk
Kevin H
KH
Kim
Colleen M
CM
Hadigan
Angela C
AC
Martino
Susan M
SM
Sereika
Judith A
JA
Erlen
D000328:Adult; D003430:Cross-Sectional Studies; D005163:Factor Analysis, Statistical; D005260:Female; D015658:HIV Infections / Q000150:complications; D006304:Health Status; D006801:Humans; D008107:Liver Diseases / Q000150:complications; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011446:Prospective Studies; D011788:Quality of Life; D015203:Reproducibility of Results