Two new triterpene glycosides from Centella asiatica.
Phytochemical investigation of the leaves of Centella asiatica resulted in the isolation and characterization of eight triterpenes and/or saponins [which were characterized as 23- O-acetylmadecassoside (1), asiatic acid (2), madecassic acid (3), asiaticoside C (4), asiaticoside F (5), asiaticoside (6), madecassoside (7), and 23- O-acetylasiaticoside B (8)] together with sitosterol 3-O-beta-glucoside ( 9), stigmasterol 3- O- beta-glucoside (10), and querectin-3- O-beta-D-glucuronide (11). A new ursane-derived saponin (23- O-acetylmadecassoside) and a new oleanane-derived saponin (23- O-acetylasiaticoside B) were found as well. Structure elucidation was done by using spectroscopic techniques (HR-ESI-MS, 1D and 2D NMR), chemical methods, and comparative literature studies.
National Center for Natural Products Research, University of Mississippi, University, MS 38677, USA.
Chidananda Swamy
CS
Rumalla
Zulfiqar
Z
Ali
Aruna D
AD
Weerasooriya
Troy J
TJ
Smillie
Ikhlas A
IA
Khan
D028041:Centella / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D018515:Plant Leaves; D012503:Saponins / Q000302:isolation & purification; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
C555598:23-O-acetylasiaticoside B; C555597:23-O-acetylmadecassoside; D006027:Glycosides; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes