Right ventricular stiffness constant as a predictor of postoperative hemodynamics in patients with hypoplastic right ventricle: a theoretical analysis.
One and a half ventricle repair (1.5VR) is a surgical option for hypoplastic right ventricle (RV). The benefits of this procedure compared to biventricular repair (2VR) or Fontan operation remain unsettled. To compare postoperative hemodynamics, we performed a theoretical analysis using a computational model based on lumped-parameter state-variable equations. We varied the RV stiffness constant (B (RV)) to simulate the various RV hypoplasia, and estimated hemodynamics for a given B (RV). With B (RV) < 150% of normal, cardiac output was the largest in 2VR. With B (RV) > 150%, cardiac output became larger in 1.5VR than in 2VR. With B (RV) > 250%, RV end-diastolic volume was almost the same between 1.5VR and 2VR, and a rapid increase in atrial pressure precluded the use of 1.5VR. These results indicate that the beneficial effect of 1.5VR depends on the RV stiffness constant. Determination of management strategy should not only be based on the morphologic parameters but also on the physiological properties of RV.
Department of Cardiovascular Dynamics, Advanced Medical Engineering Center, National Cardiovascular Center Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka, Japan. shujismz@ri.ncvc.go.jp
Shuji
S
Shimizu
Toshiaki
T
Shishido
Dai
D
Une
Atsunori
A
Kamiya
Toru
T
Kawada
Shunji
S
Sano
Masaru
M
Sugimachi
D006328:Cardiac Catheterization; D002302:Cardiac Output; D009202:Cardiomyopathies / Q000503:physiopathology / Q000601:surgery; D018729:Fontan Procedure; D006321:Heart / Q000503:physiopathology*; D006330:Heart Defects, Congenital / Q000503:physiopathology / Q000601:surgery*; D006352:Heart Ventricles / Q000002:abnormalities* / Q000503:physiopathology / Q000601:surgery*; D006439:Hemodynamics; D006801:Humans; D009139:Musculoskeletal Abnormalities / Q000503:physiopathology / Q000601:surgery; D011184:Postoperative Period; D012106:Research