Integrated gene networks in breast cancer development.
Breast cancer is a complex and heterogenous disease. Classical molecular medical approaches cannot fully understand and comprehend its pathogenesis. In this review, the development of new biological markers for the early detection and creation of guided and specific therapy of breast cancer are discussed in light of the rapid advances in the "omics". Results of cancer research in combination with large-scale methods that examine the expression status of genes and proteins have identified a large number of new biomarkers as well as confirmed the human growth hormone as an important player in the pathogenesis of this disease through its autocrine regulation where it influences the activation of Pax5 and HOXA1 gene networks.
Ratkaj
Ivana
I
Department of Biotechnology, University of Rijeka, Croatia. iratkaj@irb.hr
Stajduhar
Emil
E
Vucinic
Srdan
S
Spaventi
Sime
S
Bosnjak
Hrvojka
H
Pavelic
Kresimir
K
Kraljevic Pavelic
Sandra
S
D035843:Biomedical Research; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D053263:Gene Regulatory Networks / Q000235:genetics*; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D040901:Proteomics
D019382:Human Growth Hormone