Bunched and Madm: a novel growth-regulatory complex?
By combining Drosophila genetics and proteomics Gluderer et al. report in this issue of Journal of Biology the isolation of a novel growth-regulatory complex consisting of Bunched and Madm. Future study of this complex will address the precise mechanism of growth control, regulation of complex activity, the interface with other growth pathways and a potential role in human cancer.
Harvey
Kieran F
KF
Cell Growth and Proliferation Laboratory, Peter MacCallum Cancer Centre, 7 St Andrews Place, East Melbourne, Victoria 3002, Australia. kieran.harvey@petermac.org
D000818:Animals; D049109:Cell Proliferation; D054360:Chemokine CXCL1 / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000502:physiology*; D004331:Drosophila melanogaster / Q000502:physiology*; D017344:Genes, Insect / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D040901:Proteomics / Q000379:methods; D015398:Signal Transduction / Q000502:physiology*
C475829:CXCL1 protein, human; D054360:Chemokine CXCL1; D029721:Drosophila Proteins