[Antistroke activity of Actoinvit (substance S-1) in experimental hemorrhagic stroke].
A model of hemorrhagic stroke (HS) (intracerebral posttraumatic hematoma) has been used to show that oral Actoinvit (substance S-1) in a daily dose of 500 mg/kg for 7 days causes a steady-state antistroke effect. At the same time the major neurological parameters became lower and the total indices of orientative-trying behavior improved 24 hours just after administration of the drug. Muscle tone, coordination of movements, and memory impairment recovered on days 7-14 after the simulation of HS. The course use of the agent prevented death from HS in 80% of the animals.
V A
VA
Shestakov
E V
EV
Shestakova
D000284:Administration, Oral; D000818:Animals; D006801:Humans; D020300:Intracranial Hemorrhages / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009025:Morpholines / Q000494:pharmacology*; D051381:Rats; D020521:Stroke / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D013997:Time Factors
D009025:Morpholines; C407910:substance S1