Concordance between HER-2 and steroid hormone receptor expression between primary breast cancer, sentinel node metastases, and isolated tumor cells.
Our aim was to compare the HER-2 and hormone receptor status between primary tumor (PT) and sentinel node (SN) metastases in breast cancer. We analyzed 65 PTs with 42 macrometastases, 18 micrometastases, and 5 ITCs for the HER-2 amplification status and for the hormone receptor status. In HER-2-positive PTs, 26 of 29 metastases were HER-2-positive, including all six analyzed micrometastases and ITCs. Three macrometastases were HER-2-negative. In HER-2-negative PTs, 35 of 36 metastases were HER-2-negative. A low-grade HER-2 amplification was detected in one micrometastasis. A full concordance between the PT and SN metastases in both HER-2 amplification and ER and PR status was observed in 40 of 56 (71%) cases. These 40 fully concordant cases included 27 macrometastatic, 9 micrometastatic, and 4 ITC-cases. The concordance in HER-2, ER, and PR was high between the PT and their SN metastases. However, the concordance may be remarkably lower when analyzed simultaneously for all three predictive factors.
Strien
Leena
L
Department of Pathology, Helsinki University Central Hospital, Helsinki, Finland. leena.strien@hus.fi
Leidenius
Marjut
M
von Smitten
Karl
K
Heikkilä
Päivi
P
D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000473:pathology; D018275:Carcinoma, Lobular / Q000378:metabolism / Q000473:pathology; D047628:Estrogen Receptor alpha / Q000378:metabolism*; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology*; D009367:Neoplasm Staging; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D021701:Sentinel Lymph Node Biopsy
D014408:Biomarkers, Tumor; D047628:Estrogen Receptor alpha; D018719:Erb-b2 Receptor Tyrosine Kinases; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human