Intravenous and inhalational colistin-induced respiratory failure.
The emergence of highly resistant gram-negative pathogens in hospitals around the world has placed emphasis on colistin, a seemingly ancient drug. Respiratory failure from colistin was reported in the years following its release; however, there are no recent reports of colistin-induced respiratory failure. We report a case of intravenous colistin- and, later, inhalational colistin-induced respiratory failure.
Wahby
Krista
K
Pharmacy Department, Harper University Hospital/Hutzel Women's Hospital, Detroit Medical Center, Wayne State University, Detroit, Michigan 48201, USA. kwahby@dmc.org
Chopra
Teena
T
Chandrasekar
Pranatharthi
P
D000151:Acinetobacter Infections / Q000175:diagnosis / Q000188:drug therapy*; D040981:Acinetobacter baumannii / Q000187:drug effects / Q000302:isolation & purification; D000280:Administration, Inhalation; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D003091:Colistin / Q000008:administration & dosage* / Q000009:adverse effects*; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D018410:Pneumonia, Bacterial / Q000175:diagnosis / Q000188:drug therapy*; D012131:Respiratory Insufficiency / Q000139:chemically induced*
D000900:Anti-Bacterial Agents; D003091:Colistin