[PPARgamma agonists as potential therapeutic drugs for allergic diseases].
The nuclear receptor PPARgamma exerts a potent anti-inflammatory effects on immune cells and connective tissue cells. Accumulating evidences indicate that pathophysiological contribution of PPARgamma in allergic disease including asthma. Most recently, clinical efficacy and tolerability of PPARgamma agonists for asthma or atopic dermatitis have been reported. PPARgamma agonists seem to be new therapeutic drugs for allergic diseases, although further studies are required. Here we discuss the outlook for clinical significance of PPARgamma agonists for allergic diseases.
Ueki
Shigeharu
S
Department of Infection, Allergy, Clinical Immunology and Laboratory Medicine, Akita University Graduate School of Medicine.
Chihara
Junichi
J
D000818:Animals; D001249:Asthma / Q000188:drug therapy; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy*; D047495:PPAR gamma / Q000819:agonists*; D012220:Rhinitis / Q000188:drug therapy
D047495:PPAR gamma