Assessment of colon motility using simultaneous manometric and functional cine-MRI analysis: preliminary results.
OBJECTIVE
Gastrointestinal functional disorders are common symptoms. The evaluation of underlying colonic motility dysfunction is difficult due to lacking adequate examination techniques. Recently cine-magnetic resonance imaging (MRI) was introduced as imaging technique for visualizing colon motility. However, the correlation of MR-visible colonic-movements and real intraluminal movements was not demonstrated yet. Therefore, this feasibility study's purpose was to stimulate high amplitude propagated pressure waves (HAPPWs) by bisacodyl application under manometric control and to simultaneously identify them with cine-MRI.


METHODS
Colonoscopically, a water-perfused 8-lumen-probe was placed in descending colon. Intraluminal pressure was recorded over time. After 90 min equilibration phase, MR exam at rest (HASTE-sequence, 1.5Tesla-Avanto(®), Siemens-Medical-Solutions) was performed. Consecutively, 10 mg bisacodyl were instilled via colonic probe to induce HAPPWs. Cine-MRI and manometry were performed simultaneously over 24 min. HAPPWs were defined as pressure waves with amplitude >50 mmHg and propagation over min. three side-holes. MRI was analyzed for corresponding luminal changes of the referring colonic segment propagated aborally.


RESULTS
Ten healthy volunteers (age:19-62 years, 4 females, 6 males) were enrolled. Manometry identified 11 HAPPWs, most 9-16 min post-stimulation. All HAPPWs were identified on MRI with corresponding luminal changes (100% sensitivity).


CONCLUSIONS
In accordance with our study group's previous publications, these results show that cine-MRI allows not only for reliable HAPPWs' visualization using pharmalogical stimuli, but visualized colonic movements have 100% correlation to intraluminal pressure changes in manometry (gold-standard). This may be a first step to introduce cine-MRI for non-invasive colon motility assessment in patients with functional gastro-intestinal disorders.
Kirchhoff
Sonja
S
Institute of Clinical Radiology, Klinikum Grosshadern der Ludwig Maximilians Universität München, Germany. sonja.kirchhoff@med.uni-muenchen.de
Nicolaus
Mathias
M
Schirra
Jörg
J
Reiser
Maximilian F
MF
Göke
Burkhard
B
Lienemann
Andreas
A
D000328:Adult; D003106:Colon / Q000502:physiology*; D003113:Colonoscopy / Q000379:methods; D005240:Feasibility Studies; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology*; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008365:Manometry / Q000379:methods*; D008875:Middle Aged; D012016:Reference Values; D055815:Young Adult