Sesquiterpene lactones from Scorzonera austriaca.
Six new sesquiterpene lactones, scorzoaustriacoside (1), scorzoaustriacin (2), scorzoaustriacin 3-O-beta-d-glucoside (3), 4-epi-dihydroestafiatol (4), 14-isovaleroxyscorzoaustricin (5), and 14-isovaleroxyscorzoaustricin sulfate (6), along with five known guaianolides, were isolated from an acetone extract of the roots of Scorzonera austriaca. The structures of the new compounds were elucidated mainly by interpretation of their 1D and 2D NMR and HRMS data. Several isolates obtained in this investigation were evaluated against a small panel of cancer cell lines.
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, and Radiochemistry Laboratory, Lanzhou University, Lanzhou 730000, People's Republic of China. zhuy@lzu.edu.cn
Ying
Y
Zhu
Pei-Zhuo
PZ
Hu
Zi-Wei
ZW
He
Quan-Xiang
QX
Wu
Juan
J
Li
Wang-Suo
WS
Wu
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020014:K562 Cells; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D031186:Scorzonera / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D007783:Lactones; D012717:Sesquiterpenes