Immune response modeling of interferon beta-pretreated influenza virus-infected human dendritic cells.
The pretreatment of human dendritic cells with interferon-beta enhances their immune response to influenza virus infection. We measured the expression levels of several key players in that response over a period of 13 h both during pretreatment and after viral infection. Their activation profiles reflect the presence of both negative and positive feedback loops in interferon induction and interferon signaling pathway. Based on these measurements, we have developed a comprehensive computational model of cellular immune response that elucidates its mechanism and its dynamics in interferon-pretreated dendritic cells, and provides insights into the effects of duration and strength of pretreatment.
Department of Neurology, Mount Sinai School of Medicine, New York, New York, USA.
Liang
L
Qiao
Hannah
H
Phipps-Yonas
Boris
B
Hartmann
Thomas M
TM
Moran
Stuart C
SC
Sealfon
Fernand
F
Hayot
D000818:Animals; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000821:virology*; D005110:Extracellular Space / Q000378:metabolism; D006801:Humans; D016899:Interferon-beta / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D018448:Models, Immunological; D009975:Orthomyxoviridae / Q000276:immunology* / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology; D013997:Time Factors
D016899:Interferon-beta