Key advances in mechanisms of asthma, allergy, and immunology in 2009.
The year 2009 was marked by rapid progress in understanding cellular and chemical mechanisms in the pathogenesis of asthma and other allergic disorders. Studies published in the Journal of Allergy and Clinical Immunology described advances in our knowledge of signaling molecules and pathways, cytokines, and activation and tolerance in asthma and murine models of this disease; food allergy; anaphylaxis and immediate hypersensitivity; mast cells and their disorders; atopic dermatitis; allergic conjunctivitis; nasal polyposis; and hypereosinophilic syndromes. Additional studies provided novel information about the induction and regulation of allergic inflammation and the genetic determinants of asthma and responsiveness to asthma therapy. Critical features of these studies and their potential effect on human atopic disorders are summarized here.
Finkelman
Fred D
FD
Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio, USA. ffinkelman@pol.net
Boyce
Joshua A
JA
Vercelli
Donata
D
Rothenberg
Marc E
ME
D018926:Anti-Allergic Agents / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D007107:Immune System / Q000503:physiopathology*
D018926:Anti-Allergic Agents