[Importance of the nuclear factor kappaB for the primary open angle glaucoma--a hypothesis].
The primary open-angle glaucoma (POAG) is an optic neuropathy which is influenced by a number of different risk factors. Some of them can induce the transcriptional factor NF-kappaB, a nuclear protein which binds to specific areas of the DNA to stimulate different genes. NF-kappaB can be activated by increased intraocular pressure, increased age, vascular diseases and by oxidative stress. In the case of POAG NF-kappaB might be overstimulated with the induction of uncontrolled biochemical reactions. Treatment strategies for reducing NF-kappaB are to reduce intraocular pressure as well as therapies with statins, omega-3-fatty acids and alpha-lipoic acid. This model is a hypothesis and is intended to provide a basis for further discussions and basic research.
Abteilung für Augenheilkunde, Schlosspark-Klinik. carl.erb@schlosspark-klinik.de
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D000367:Age Factors; D000368:Aged; D019332:Endothelin-1 / Q000502:physiology; D005902:Glaucoma, Open-Angle / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007429:Intraocular Pressure / Q000235:genetics / Q000502:physiology; D016328:NF-kappa B / Q000235:genetics / Q000502:physiology*; D009901:Optic Nerve Diseases / Q000235:genetics / Q000503:physiopathology; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology; D012307:Risk Factors; D014129:Trabecular Meshwork / Q000503:physiopathology; D015533:Transcriptional Activation / Q000235:genetics / Q000502:physiology
D019332:Endothelin-1; D016328:NF-kappa B