Integrated gene networks in breast cancer development.
Breast cancer is a complex and heterogenous disease. Classical molecular medical approaches cannot fully understand and comprehend its pathogenesis. In this review, the development of new biological markers for the early detection and creation of guided and specific therapy of breast cancer are discussed in light of the rapid advances in the "omics". Results of cancer research in combination with large-scale methods that examine the expression status of genes and proteins have identified a large number of new biomarkers as well as confirmed the human growth hormone as an important player in the pathogenesis of this disease through its autocrine regulation where it influences the activation of Pax5 and HOXA1 gene networks.
Department of Biotechnology, University of Rijeka, Croatia. iratkaj@irb.hr
Ivana
I
Ratkaj
Emil
E
Stajduhar
Srdan
S
Vucinic
Sime
S
Spaventi
Hrvojka
H
Bosnjak
Kresimir
K
Pavelic
Sandra
S
Kraljevic Pavelic
D035843:Biomedical Research; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D053263:Gene Regulatory Networks / Q000235:genetics*; D019382:Human Growth Hormone / Q000378:metabolism; D006801:Humans; D040901:Proteomics
D019382:Human Growth Hormone