Tellimagrandin I, HCV invasion inhibitor from Rosae Rugosae Flos.
By use of the model virus, expressing the HCV envelope proteins E1 and E2, bioassay guided separation of the MeOH extract from Rosa rugosa Thunb. disclosed tellimagrandin I (1) together with eugeniin (2) and casuarictin (3) as the potent HCV invasion inhibitors. Furthermore, structure-activity relationship analysis of some relative tannins including the synthesized analogs elucidated the partial structures crucial for potent activity of 1.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka Suita, Osaka 565-0871, Japan.
Satoru
S
Tamura
Gang-Ming
GM
Yang
Natsuko
N
Yasueda
Yoshiharu
Y
Matsuura
Yasumasa
Y
Komoda
Nobutoshi
N
Murakami
D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D027824:Rosaceae / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014759:Viral Envelope Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D016662:Virus Integration / Q000187:drug effects*
D000998:Antiviral Agents; D001713:Biphenyl Compounds; C087035:E1 protein, Hepatitis C virus; D005960:Glucosides; D014759:Viral Envelope Proteins; C091015:glycoprotein E2, Hepatitis C virus; C110634:eugeniin; D005707:Gallic Acid; C073064:casuarictin; C087926:tellimagrandin I