Distribution of HPV types associated with cervical cancers in Scotland and implications for the impact of HPV vaccines.
METHODS
This study evaluated human papillomavirus (HPV) type prevalence in 370 Scottish invasive cervical cancers (ICCs) using HPV genotyping and HPV mRNA detection.


RESULTS
HPV 16 and/or 18 was detected in 72% of cancers overall and in 82% of HPV-positive cancers. HPV 45 and 16 were the most frequently transcribed types.


CONCLUSIONS
A significant reduction in ICC in Scotland should be achieved through the HPV immunisation programme.
Scottish HPV Reference Laboratory, Specialist Virology Centre, Royal Infirmary of Edinburgh, Edinburgh, UK.
K
K
Cuschieri
D H
DH
Brewster
A R W
AR
Williams
D
D
Millan
G
G
Murray
S
S
Nicoll
J
J
Imrie
A
A
Hardie
C
C
Graham
H A
HA
Cubie
D000230:Adenocarcinoma / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000145:classification / Q000235:genetics*; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology; D053918:Papillomavirus Vaccines / Q000627:therapeutic use*; D011379:Prognosis; D012606:Scotland / Q000453:epidemiology; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000517:prevention & control* / Q000821:virology
D053918:Papillomavirus Vaccines