[Effects of transcatheter closure of patent ductus arteriosus in 139 adult patients].
OBJECTIVE
To analyze the clinical feature and the effects of transcatheter closure of adult patients with patent ductus arteriosus (PDA).


METHODS
Between January 2000 and April 2009, 139 patients [22 male, aged from 40 to 74: (49.8 +/- 6.8) years] with PDA were hospitalized in our hospital. Clinical data and effects of transcatheter closure of PDA were analyzed.


RESULTS
There were 64 patients with NYHA classI, 53 with class II, 16 with class III and 6 with class IV before procedure. In 139 patients, pulmonary arterial hypertension (PAH) was found in 107 out of 139 patients (77.0%). Transcatheter PDA closure was not performed in 3 patients due to severe PAH and successfully performed in the remaining 136 patients (97.8%) without major complications. Post procedure aortic angiography evidenced minor residual shunt in 14 cases, small residual shunt in 2 cases and moderate shunt in 1 case. The NYHA class was significantly improved and the PAH significantly reduced [sPAP: (47.3 +/- 23.9) mm Hg (1 mm Hg = 0.133 kPa) vs. (28.1 +/- 12.3) mm Hg, P < 0.01] post procedure.


CONCLUSIONS
PAH and heart failure were commonly associated with PDA in adult patients. Transcatheter PDA closure is safe and effective in these patients except those with severe PAH.
Zhu
Xian-Yang
XY
Department of Congenital Heart Disease, General Hospital of Shenyang Military Region, Shenyang 110016, China.
Chen
Huo-Yuan
HY
Zhang
Duan-Zhen
DZ
Han
Xiu-Min
XM
Sheng
Xiao-Tang
XT
Cui
Chun-Sheng
CS
Zhang
Po
P
Wang
Qi-Guang
QG
D000328:Adult; D000368:Aged; D006328:Cardiac Catheterization / Q000009:adverse effects; D004374:Ductus Arteriosus, Patent / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D016896:Treatment Outcome