Locomotion analysis of Sprague-Dawley rats before and after injecting 6-OHDA.
The hypothesis that changes in measured ground reaction forces and time parameters during locomotion can noninvasively detect Parkinsonism in unilateral 6-OH dopamine (6-OHDA) lesioned rats is tested. It was found that changes of seven locomotion parameters can be used to construct a logistic regression model with a detection sensitivity and specificity of over 90% as compared to non-lesioned rats. Comparisons between this model and other neurological and neuromuscular disorders are presented.
Tang
Wenlong
W
Department of Mechanical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States.
McDowell
Kim
K
Limsam
Mark
M
Neerchal
Nagaraj K
NK
Yarowsky
Paul
P
Tasch
Uri
U
D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis; D000818:Animals; D001696:Biomechanical Phenomena; D004195:Disease Models, Animal; D008124:Locomotion; D016015:Logistic Models; D018482:Muscle, Skeletal / Q000293:injuries; D016627:Oxidopamine; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000175:diagnosis*; D011336:Probability; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D012680:Sensitivity and Specificity; D013997:Time Factors
D016627:Oxidopamine