Changes of serum omentin-1 levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2 diabetes.
OBJECTIVE
To assay the levels of serum omentin-1 in subjects with different levels of glucose regulation and to analyze the relationship between serum omentin-1 levels and body mass index (BMI), glycoslated hemoglobin (HbA1c), plasma glucose, insulin resistance index (HOMA-IR), TNF-alpha and IL-6 levels.


METHODS
Forty-six patients with impaired glucose regulation (IGR), 55 patients with newly diagnosed and untreated type 2 diabetes mellitus (T2DM), and 50 subjects with normal glucose tolerance (NGT) were enrolled in this study. The levels of serum omentin-1 and plasma glucose at fasting and at 2h after glucose load and fasting serum levels of TNF-alpha, IL-6, insulin, and HbA1c were measured. HOMA-IR was calculated.


RESULTS
The levels of serum omentin-1 were lower in the IGR and T2DM groups than in the NGT group. Within groups, omentin-1 levels were no significant difference before and after glucose load. The level of serum omentin-1 was negatively correlated to BMI, HOMA-IR, fasting insulin, TNF-alpha, IL-6, plasma glucose. HOMA-IR and BMI were independent related factors that influenced the levels of serum omentin-1.


CONCLUSIONS
Serum omentin-1 levels were decreased in impaired glucose regulation subjects. Lack of omentin-1 may contribute to the development of insulin resistance and T2DM.
Department of Endocrinology & Metabolism, 2nd Affiliated Hospital of Harbin Medical University, Heilongjiang, China.
Hong-Yan
HY
Pan
Lin
L
Guo
Qiang
Q
Li
D001786:Blood Glucose / Q000378:metabolism*; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy*; D004797:Enzyme-Linked Immunosorbent Assay; D058851:GPI-Linked Proteins; D005947:Glucose; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D015850:Interleukin-6 / Q000097:blood; D037102:Lectins / Q000097:blood*; D011863:Radioimmunoassay; D012044:Regression Analysis; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D001786:Blood Glucose; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D007328:Insulin; D015850:Interleukin-6; D037102:Lectins; D014409:Tumor Necrosis Factor-alpha; D005947:Glucose