Facile syntheses of enantiopure 3-hydroxypiperidine derivatives and 3-hydroxypipecolic acids.
Facile syntheses of enantiopure trans- and cis-3-hydroxypiperidine derivatives and 3-hydroxypipecolic acids are reported, featuring Rh-catalyzed cyclohydrocarbonylation through common intermediates. A diaxial conformation in a 2,3-disubstituted N-Boc-piperidinyl structure is revealed by an X-ray crystallographic analysis.
Chiou
Wen-Hua
WH
Department of Chemistry, National Chung Hsing University, Taichung, Taiwan, R.O.C. wchiou@dragon.nchu.edu.tw
Lin
Gau-Hong
GH
Liang
Chih-Wei
CW
D002384:Catalysis; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010848:Picolinic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D010848:Picolinic Acids; D010880:Piperidines; C049246:3-hydroxypicolinic acid