[Efficiency of immunohistochemical study of high-molecular-weight cytokeratins (CKR-HMW) and p63 in prostate trepan biopsy specimens for establishing the diagnosis of adenocarcinoma].
Early diagnosis of prostate cancer is one of the most important problems of modern oncology. Trepan biopsy and further histological investigation are the standards for examination of patients with prostate neoplasms. Our investigations of 56 cases have indicated that in 27% of the cases, histological investigation is insufficient to make a valid diagnosis. In such cases, immunohistochemical evaluation of the expression of high-molecular-weight cytokeratins and p63 allows differentiation of carcinoma from benign masses of the prostate, which may be used to enhance the efficiency of early diagnosis of prostate cancer.
Raskin
G A
GA
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007633:Keratins / Q000096:biosynthesis*; D008297:Male; D011467:Prostate / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D012680:Sensitivity and Specificity; D015534:Trans-Activators / Q000096:biosynthesis*; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis*
C115051:TP63 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins; D007633:Keratins