Maternal acute lymphoctic leukemia with rearrangement of the mixed lineage leukemia gene occurring during pregnancy.
Acute lymphoblastic leukemia (ALL) is a relatively rare disease during pregnancy, accounting for about 15% of all cases of pregnancy-associated leukemia. Although mixed lineage leukemia gene (MLL) rearrangement is the dominant genetic aberration in infantile acute leukemia, the occurrence of MLL gene rearrangement in maternal ALL occurring during pregnancy has not been reported. Out of 31 cases of maternal leukemia diagnosed during pregnancy at our institution, 5 were ALL cases. Three of the 5 patients had MLL gene rearrangement. The data for these 5 patients are presented in this report. We believe that the association of MLL gene rearrangement with maternal leukemia is biologically plausible and this observation needs to be validated in a larger cohort of pregnancy-associated maternal leukemia cases.
King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Mahmoud
M
Aljurf
Amr
A
Nassar
Abu J
AJ
Saleh
Fahed
F
Almhareb
Hazzaa
H
Alzahrani
Claudia
C
Walter
Mohammad
M
Bakr
Syed Osman
SO
Ahmed
Naeem
N
Chaudhri
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D019070:Cell Lineage; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D003131:Combined Modality Therapy; D005260:Female; D015321:Gene Rearrangement; D005865:Gestational Age; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D051788:Myeloid-Lymphoid Leukemia Protein / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D011379:Prognosis; D033581:Stem Cell Transplantation; D014178:Translocation, Genetic; D055815:Young Adult
C497422:KMT2A protein, human; D051788:Myeloid-Lymphoid Leukemia Protein; D011495:Histone-Lysine N-Methyltransferase