The evolution of protease mutation 76V is associated with protease mutation 46I and gag mutation 431V.
Recently, first-line lopinavir failure was observed due to protease mutation 76V. In the present study, we found 76V associated with protease mutation 46I and gag cleavage-site mutation 431V. Longitudinal analysis of patients failing protease inhibitor therapies demonstrated that 76V strictly occurs either together with 46I and/or 431V or in HIV isolates already harbouring one of both mutations. Therefore, all three mutations seem to cooperate in terms of protease inhibitor resistance.
University of Cologne, Institute of Virology, Cologne, Germany.
Elena
E
Knops
Ina
I
Kemper
Eugen
E
Schülter
Herbert
H
Pfister
Rolf
R
Kaiser
Jens
J
Verheyen
D024882:Drug Resistance, Viral / Q000235:genetics*; D019143:Evolution, Molecular; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000235:genetics*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D061466:Lopinavir; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D011744:Pyrimidinones / Q000627:therapeutic use; D017422:Sequence Analysis, DNA; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000235:genetics*; D054302:pol Gene Products, Human Immunodeficiency Virus / Q000235:genetics*
D017320:HIV Protease Inhibitors; D011744:Pyrimidinones; D054301:gag Gene Products, Human Immunodeficiency Virus; D054302:pol Gene Products, Human Immunodeficiency Virus; D061466:Lopinavir