Polybioside, a neuroactive compound from the venom of the social wasp Polybia paulista.
Polybioside (1) was isolated from the venom of the social wasp Polybia paulista, and its structure was assigned as 3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl 3-(1H-imidazol-4-yl)propanimidate by NMR and MS protocols. The application of polybioside in rat brain, followed by the detection of c-Fos protein expression in some brain regions, indicated the compound is neuroactive in a number of brain areas. Polybioside causes convulsions in rats, even when peripherally applied.
Laboratory of Structural Biology and Zoochemistry, Department of Biology/CEIS, Institute of Biosciences, São Paulo State University (UNESP), 13506-900, Rio Claro, SP, Brazil.
Daniel M
DM
Saidemberg
Luiz C
LC
da Silva-Filho
Lilian M M Cesar
LM
Tognoli
Claudio F
CF
Tormena
Mario S
MS
Palma
D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects; D001938:Brazil; D002491:Central Nervous System Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007093:Imidazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008297:Male; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects; D019906:Nuclear Magnetic Resonance, Biomolecular; D016760:Proto-Oncogene Proteins c-fos / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced; D014862:Wasp Venoms / Q000737:chemistry*; D014863:Wasps / Q000737:chemistry*
D002491:Central Nervous System Agents; D005960:Glucosides; D007093:Imidazoles; D016760:Proto-Oncogene Proteins c-fos; D014862:Wasp Venoms; C549603:polybioside