The many facets of the Tim-Tipin protein families' roles in chromosome biology.
Failures in DNA replication are a potent force for driving genome instability. The proteins which form the replisome, the DNA replication machinery, play a fundamental role in preventing replicative catastrophes. The Tim (TIMELESS/TIMEOUT) and Tipin proteins are two conserved replisome associated proteins which have functions in preventing replication fork collapse and replicative checkpoint signalling in response to factors which slow the progression of the replisome. Intriguingly, TIMELESS family members have been implicated in the regulation of the biological clock, giving a tantalising pointer to a possible link between DNA replication and circadian rhythm control. Here we report on our current understanding of the many facets of these protein families in maintaining genome stability and replication checkpoint control.
North West Cancer Research Fund Institute, College of Natural Sciences, Bangor University, Bangor, Gwynedd, UK. r.macfarlane@bangor.ac.uk
Ramsay J
RJ
McFarlane
Saira
S
Mian
Jacob Z
JZ
Dalgaard
D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000378:metabolism; D004330:Drosophila; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D042822:Genomic Instability; D008954:Models, Biological; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D029701:Saccharomyces cerevisiae Proteins; C119636:TOF1 protein, S cerevisiae; C096445:tim protein, Drosophila