[Analysis of survival rates in patients and prognostic models in non-metastatic clear-cell renal cell carcinoma].
The Cox multivariate regression analysis of survival rates in patients with non-metastatic clear-cell renal cell carcinoma, by taking into account both various clinical, anatomic, morphometric, and biomolecular factors and kariometric parameters, has revealed that Ki-67 and p53 expression rates along with histologic grade, a tumor portion made up of clear-cell components, and the presence/absence of tumor invasion into paranephral fat tissue are independent prognostic predictors of the disease. By applying the proposed three prognostic models (algorithms) using Ki-67 and p53 expression rates for predicting the corrected survival rates for patients with non-metastatic clear-cell renal cell carcinoma, the authors suggest that a combined biomolecular-morphometric model is of the greatest prognostic value.
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Koval'skiĭ
D002292:Carcinoma, Renal Cell / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D007680:Kidney Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D008297:Male; D009362:Neoplasm Metastasis; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D019394:Ki-67 Antigen; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53