Anti-hepatitis B virus activity of new substituted pyrimidine acyclic nucleoside analogues.
A number of N-substituted pyrimidine acyclic nucleosides were synthesized by coupling reaction of 2-(2-chloroethoxy)ethyl acetate or (2,2-dimethyl-1,3-dioxolan-4-yl)methyl 4-methylbenzenesulfonate with the corresponding base followed by deprotection. The synthesized compounds were tested for their antiviral activity against hepatitis B virus (HBV). The plaque reduction infectivity assay was used to determine virus count reduction as a result of treatment with the synthesized compounds which showed moderate to high antiviral activities.
Chemistry Department, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt. adelnassar63@hotmail.com
Adel A-H
AA
Abdel-Rahman
Ibrahim F
IF
Zeid
Hussien A
HA
Barakat
Wael A
WA
El-Sayed
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017931:DNA Primers; D004279:DNA, Viral / Q000235:genetics; D006515:Hepatitis B virus / Q000187:drug effects*; D008958:Models, Molecular; D016133:Polymerase Chain Reaction; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared
D000998:Antiviral Agents; D017931:DNA Primers; D004279:DNA, Viral; D011741:Pyrimidine Nucleosides