HIV-1 elite controllers: beware of super-infections.
Super- and co-infection with HIV-1 are generally associated with accelerated disease progression. We report on the outcome of super-infection in two HIV-1 infected individuals previously known as elite controllers. Both presented an acute retroviral syndrome following super-infection and showed an immuno-virological progression thereafter. Host genotyping failed to reveal any of the currently recognized protective factors associated with slow disease progression. This report indicates that elite controllers should be informed of the risk of super-infection, and illustrates the complexity of mounting broad anti-HIV immunity.
Clerc
Olivier
O
Infectious Diseases Service, Centre Hospitalier Universitaire Vaudois and University of Lausanne, Lausanne 1011, Switzerland. olivier.clerc@chuv.ch
Colombo
Sara
S
Yerly
Sabine
S
Telenti
Amalio
A
Cavassini
Matthias
M
D000328:Adult; D005260:Female; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D020276:HIV Long-Term Survivors; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D015163:Superinfection