[Morphological characteristics of HCV cirrhosis of the liver].
Pathomorphological changes were analyzed in the HCV-cirrhotic liver of patients with varying decompensation of the organ 's function. The decompensation of liver function in HCV cirrhosis was shown to be directly related to the infectious process. It is conceivable that it is to a greater degree determined by an autoimmune response, as confirmed by lower blood virus replicative activity, NS3 protein expression in the cells of an inflammatory infiltrate in the portal tract, and reduced detection rates for NS3 protein expression in the hepatocytic cytoplasm as the pathological process progresses.
Chirskiĭ
V S
VS
Zhdanov
K V
KV
Gusev
D A
DA
Alent'ev
G A
GA
D003593:Cytoplasm / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015967:Gene Expression Regulation, Viral; D016174:Hepacivirus; D006526:Hepatitis C / Q000378:metabolism / Q000473:pathology*; D022781:Hepatocytes / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D008103:Liver Cirrhosis / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D008297:Male; D017361:Viral Nonstructural Proteins / Q000096:biosynthesis; D014779:Virus Replication; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases