Ki67 in breast cancer: prognostic and predictive potential.
The leading parameters that define treatment recommendations in early breast cancer are oestrogen-receptor, progesterone-receptor, and human epidermal growth-factor status. Although some pathologists report Ki67 in addition to other biological markers, the existing guidelines of the American Society of Clinical Oncology do not include Ki67 in the list of required routine biological markers. The advent of new genetic tests has emphasised the role of proliferative genes, including Ki67, as prognostic and predictive markers. Additionally, randomised studies have retrospectively reviewed data and reported on the role of Ki67 in breast cancer. In light of new data, we have re-assessed evidence that could change guidelines to include Ki67 in the standard pathological assessment of early breast cancers. This review provides an update on the current knowledge on Ki67 and of the evidence in the published work about the prognostic and predictive role of this marker, and provides information on the laboratory techniques used to determine Ki67.
Division of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada. ryerushalmi@bccancer.bc.ca
Rinat
R
Yerushalmi
Ryan
R
Woods
Peter M
PM
Ravdin
Malcolm M
MM
Hayes
Karen A
KA
Gelmon
D015415:Biomarkers / Q000032:analysis; D001943:Breast Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000235:genetics*; D011237:Predictive Value of Tests; D011379:Prognosis
D015415:Biomarkers; D019394:Ki-67 Antigen