[Clinical significance of liver function and autoantibodies in patients with acute or chronic drug-induced liver injury].
OBJECTIVE
To investigate the clinical significance of liver function and autoantibodies in patients with acute or chronic drug-induced liver injury.


METHODS
51 patients with drug-induced liver injury were divided into acute drug induced liver injury group and chronic drug induced liver injury group, liver function and autoantibodies were compared between these two groups.


RESULTS
There was no significant difference (P more than 0.05) in alanine aminotransferase [(412.1+/-387.5) U/L and (376.0+/-319.7) U/L], aspartate aminotransferase [(352.5+/-457.9) U/L and (198.8+/-142.7) U/L], total bilirubin [(109.7+/-104.80)micromol/L and(102.4+/-135.7)micromol/L], direct bilirubin [(66.4+/-73.3)micromol/L and (61.2+/-72.1)micromol/L], alkaline phosphatase [(133.4+/-50.1) U/L and (147.4+/-97.3) U/L], gamma-glutamyltransferase [(139.9+/-134.1) U/L and (180.6+/-227.9) U/L], and albumin [(41.3+/-4.9) g/L and (39.8+/-5.3)g/L] between these two groups, however, the level of globulin [(25.1+/-5.3) g/L and (28.6+/-5.1) g/L] was significantly different between these two groups (P less than 0.05). The titers of Anti-nuclear antibody (ANA) and smooth muscle antibody (SMA) were less than or equal to 1:320 in patients with acute drug induced liver injury. The titers of ANA, antimitochondrial antibody (AMA), and SMA were more than or equal to 1:320 in most of the patients with chronic drug induced liver injury.


CONCLUSIONS
Liver function has no value in the diagnosis of acute or chronic drug induced liver injury. High titer autoantibodies are found in patients with chronic drug induced liver injury.
Department of Immunity and Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Yan-Min
YM
Liu
Hui-Ping
HP
Yan
Ying
Y
Han
Li-Jie
LJ
Zhang
Yan
Y
Liu
Hui-Yu
HY
Liao
Yi-Sen
YS
Chen
Yun-Li
YL
Huang
Guo-Qing
GQ
Zhao
Hui-Guo
HG
Ding
D000208:Acute Disease; D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood* / Q000175:diagnosis / Q000276:immunology*; D003937:Diagnosis, Differential; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D008861:Microsomes / Q000276:immunology; D008875:Middle Aged; D009130:Muscle, Smooth / Q000276:immunology
D000974:Antibodies, Antinuclear; D001323:Autoantibodies