Infant CD4 C868T polymorphism is associated with increased human immunodeficiency virus (HIV-1) acquisition.
The C868T single nucleotide polymorphism (SNP) in the CD4 receptor encodes an amino acid change that could alter its structure and influence human immunodeficiency virus (HIV-1) infection risk. HIV-1-infected pregnant women in Nairobi were followed with their infants for 1 year postpartum. Among 131 infants, those with the 868T allele were more likely than wild-type infants to acquire HIV-1 overall [hazard ratio (HR) = 1.92, 95% confidence interval (CI) 1.05, 3.50, P = 0.03; adjusted HR = 2.03, 95% CI 1.03, 3.98, P = 0.04], after adjusting for maternal viral load. This SNP (an allele frequency of approximately 15% in our cohort) was associated with increased susceptibility to mother-to-child HIV-1 transmission, consistent with a previous study on this polymorphism among Nairobi sex workers.
Department of Medicine, University of Washington, Seattle, WA 98104, USA. ryc@u.washington.edu
R Y
RY
Choi
C
C
Farquhar
J
J
Juno
D
D
Mbori-Ngacha
B
B
Lohman-Payne
F
F
Vouriot
S
S
Wayne
J
J
Tuff
R
R
Bosire
G
G
John-Stewart
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K
Fowke
D000328:Adult; D000483:Alleles; D015704:CD4 Antigens / Q000235:genetics* / Q000276:immunology; D015331:Cohort Studies; D005260:Female; D005787:Gene Frequency; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology / Q000635:transmission*; D015497:HIV-1; D006801:Humans; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000235:genetics / Q000276:immunology / Q000821:virology
D015704:CD4 Antigens