Microwave-assisted synthesis of substituted 2-(benzylthio)imidazo[1,2a]pyrimidin-5-ones.
A microwave-assisted solid-phase synthesis of 2-(benzylthio)imidazo[1,2a]pyrimidin-5-ones has been developed. Using microwave irradiation, the reaction time was significantly reduced from a few days to 80 min. A representative set of 10 2-(benzylthio)-6,7-substituted-imidazo[1,2a]pyrimidin-5-ones was prepared. These compounds were subsequently N-alkylated and formylated in good yields.
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Chai Hoon
CH
Soh
Yulin
Y
Lam
D000478:Alkylation; D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D008872:Microwaves; D011744:Pyrimidinones / Q000138:chemical synthesis*; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared
D011744:Pyrimidinones