Antihyperglycaemic effect of an unusual amino acid (4-hydroxyisoleucine) in C57BL/KsJ-db/db mice.
The present report confirms the anti-hyperglycaemic and anti-dyslipidemic properties of 4-hydroxyisoleucine, an unusual amino acid isolated from Trigonella foenum-graecum seeds, for the first time in a well-characterised model of type II diabetes, i.e. db/db mice. 4-Hydroxyisoleucine, when given orally to these mice at 50 mg kg(-1) dose level, significantly (p < 0.05) declined their elevated blood glucose, plasma insulin, triglycerides, total cholesterol, low-density lipoprotein-cholesterol levels and raised their declined plasma high-density lipoprotein-cholesterol level. These results indicate that 4-hydroxyisoleucine exhibits significant potential as an anti-diabetic agent by suppressing progression of type II diabetic states that is suggested by enhancement of insulin sensitivity and glucose uptake in peripheral tissue.
Singh
A B
AB
Biochemistry Division, Central Drug Research Institute, Lucknow-226001, Uttar Pradesh, India.
Tamarkar
A K
AK
Narender
T
T
Srivastava
Arvind Kumar
AK
D000818:Animals; D001786:Blood Glucose; D001835:Body Weight; D003920:Diabetes Mellitus / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D007532:Isoleucine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D012639:Seeds / Q000737:chemistry; D029910:Trigonella / Q000737:chemistry
C104672:4-hydroxyisoleucine; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007532:Isoleucine