Steroid hormones controlling the life cycle of the nematode Caenorhabditis elegans: stereoselective synthesis and biology.
Cholesterol-derived hormones, the dafachronic acids, play a major role in controlling the life cycle and initiating dauer larva formation of the nematode Caenorhabditis elegans. This Perspective describes recent progress in the synthesis of these steroid hormones and their biological function.
Martin
René
R
Department Chemie, Technische Universität Dresden, Bergstrasse 66, 01069 Dresden, Germany.
Entchev
Eugeni V
EV
Kurzchalia
Teymuras V
TV
Knölker
Hans-Joachim
HJ
D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000096:biosynthesis / Q000502:physiology*; D002784:Cholesterol / Q000494:pharmacology; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects / Q000502:physiology; D017238:Genes, Helminth; D006728:Hormones / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects / Q000502:physiology; D008018:Life Cycle Stages / Q000187:drug effects* / Q000502:physiology; D008136:Longevity / Q000187:drug effects; D015398:Signal Transduction / Q000502:physiology; D013237:Stereoisomerism; D013256:Steroids / Q000494:pharmacology*
D029742:Caenorhabditis elegans Proteins; D006728:Hormones; D013256:Steroids; D002784:Cholesterol