[Dose-dependent effects of neuroimmunomodulator interferon alpha on behavior of humans and animals].
The review analyses the literature on polyfunctional activity of the cytokine interferon-alpha (IA) which has neuroimmunomodulatory properties and is used for treatment of viral and oncologic diseases. The major intention is devoted to action of small and high doses of IA on different forms of animals and human behavior. We suggest that chronic treatment with small IA doses is more effective than high dose therapy.
E V
EV
Loseva
N A
NA
Loginova
I G
IG
Akmaev
D000818:Animals; D000998:Antiviral Agents / Q000276:immunology / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D016898:Interferon-alpha / Q000276:immunology / Q000627:therapeutic use*; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology; D015213:Neuroimmunomodulation / Q000187:drug effects* / Q000276:immunology; D014777:Virus Diseases / Q000188:drug therapy / Q000276:immunology
D000998:Antiviral Agents; D016898:Interferon-alpha