Unconventional secretion by autophagosome exocytosis.
In this issue, Duran et al. (2010. J. Cell Biol. doi: 10.1083/jcb.200911154) and Manjithaya et al. (2010. J. Cell Biol. doi: 10.1083/jcb.200911149) use yeast genetics to reveal a role for autophagosome intermediates in the unconventional secretion of an acyl coenzyme A (CoA)-binding protein that lacks an endoplasmic reticulum signal sequence. Medium-chain acyl CoAs are also required and may be important for substrate routing to this pathway.
Department of Biochemistry, School of Medicine, Stanford University, Stanford, CA 94305, USA. pfeffer@stanford.edu
Suzanne R
SR
Pfeffer
D000818:Animals; D001343:Autophagy / Q000235:genetics / Q000502:physiology*; D004023:Dictyostelium / Q000378:metabolism; D005089:Exocytosis; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D010588:Phagosomes / Q000378:metabolism*; D010843:Pichia / Q000166:cytology / Q000235:genetics / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000235:genetics / Q000378:metabolism
D005656:Fungal Proteins