Imaging the human medial temporal lobe with high-resolution fMRI.
High-resolution functional MRI (hr-fMRI) affords unique leverage on the functional properties of human medial temporal lobe (MTL) substructures. We review initial hr-fMRI efforts to delineate (1) encoding and retrieval processes within the hippocampal circuit, (2) hippocampal subfield contributions to pattern separation and pattern completion, and (3) the representational capabilities of distinct MTL subregions. Extant data reveal functional heterogeneity within human MTL and highlight the promise of hr-fMRI for bridging human, animal, and computational approaches to understanding MTL function.
Department of Psychology, Stanford University, Stanford, CA 94305, USA. valerie.carr@stanford.edu
Valerie A
VA
Carr
Jesse
J
Rissman
Anthony D
AD
Wagner
D000818:Animals; D001931:Brain Mapping; D000077463:Carbamide Peroxide; D004338:Drug Combinations; D006624:Hippocampus / Q000098:blood supply; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D009415:Nerve Net / Q000098:blood supply; D009434:Neural Pathways / Q000098:blood supply; D010545:Peroxides / Q000097:blood*; D013702:Temporal Lobe / Q000098:blood supply*; D014508:Urea / Q000031:analogs & derivatives* / Q000097:blood
D004338:Drug Combinations; D010545:Peroxides; D000077463:Carbamide Peroxide; D014508:Urea