Histone acetylation by HBO1 tightens replication licensing.
In this issue of Molecular Cell, Miotto and Struhl (2010) suggest that replication licensing, the loading of Mcm2-7 onto DNA, is promoted by HBO1 acetylating histone H4 at replication origins, providing a molecular view of how chromatin status influences origin usage.
Wellcome Trust Centre for Gene Regulation & Expression, University of Dundee, Dow Street, Dundee DD1 5EH, UK.
Gaganmeet Singh
GS
Chadha
J Julian
JJ
Blow
D000107:Acetylation; D002843:Chromatin / Q000378:metabolism; D004261:DNA Replication; D051548:Histone Acetyltransferases / Q000502:physiology*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008957:Models, Genetic
D002843:Chromatin; D006657:Histones; D051548:Histone Acetyltransferases; C496553:KAT7 protein, human