Analytical radiography for planar radiographic images implemented with a multi-modal system.
A radiographic system is optimized for the contrast inherent to small animals and is developed for a multi-modal imaging system devised for in-vivo studies. The range of X-ray energies utilized (generally considered "soft X-rays") enables enhanced spatial resolution and superior contrast for detailed study of the mouse anatomy and smaller specimens. Despite the difficulties presented by the complicated energy spectrum of soft X-rays, relevant system calibrations for bone measures are described in detail and applied to the mouse. Further, long-bone symmetry modeling using a cylindrical projection is applied to the planar density image, providing convenient bone density estimates that are consistent with other methodologies.
Vizard
Douglas L
DL
Carestream Molecular Imaging, Carestream Health, Inc., Woodbridge, CT, USA. douglas.vizard@carestreamhealth.com
Wood
Douglas O
DO
Papineni
Rao V L
RV
Feke
Gilbert D
GD
Orton
Sean P
SP
McLaughlin
William E
WE
D000818:Animals; D015519:Bone Density; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D051379:Mice; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*