The control of inhibited fourth-stage larvae of Haemonchus contortus and Teladorsagia spp. in sheep in Australia with monepantel.
Monepantel is the first molecule from the amino-acetonitrile derivatives to be developed for controlling gastro-intestinal nematodes in sheep. Two studies were undertaken to examine the drug's efficacy against inhibited fourth-stage larvae of Haemonchus contortus and Teladorsagia spp. in sheep when administered as an oral solution at 2.5mg/kg bodyweight. In study 1, efficacy was 99.7% against H. contortus (p<0.0001) and in study 2, 99.8% against Teladorsagia spp. (p<0.0001). This population consisted of 93% T. circumcincta and 7% T. trifurcata. In conclusion, monepantel is a highly effective treatment against inhibited fourth-stage larvae of H. contortus and Teladorsagia spp. and the studies reported here provide the first published evidence of efficacy of this new anthelmintic against these parasites.
Novartis Animal Health Australasia Pty Limited, Clinical Development, Yarrandoo R&D Centre, 245 Western Road, Kemps Creek, NSW 2178, Australia. philip.stein@novartis.com
P A
PA
Stein
P F
PF
Rolfe
B C
BC
Hosking
D000607:Aminoacetonitrile / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D001315:Australia; D005260:Female; D006188:Haemonchiasis / Q000188:drug therapy / Q000662:veterinary*; D006189:Haemonchus / Q000187:drug effects* / Q000254:growth & development; D007814:Larva / Q000187:drug effects / Q000254:growth & development; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology; D016896:Treatment Outcome; D014251:Trichostrongyloidea / Q000187:drug effects* / Q000254:growth & development; D014252:Trichostrongyloidiasis / Q000188:drug therapy / Q000662:veterinary*
D000871:Anthelmintics; D000607:Aminoacetonitrile; C533978:monepantel