Predictive value of baseline serum vascular endothelial growth factor and neutrophil gelatinase-associated lipocalin in advanced kidney cancer patients receiving sunitinib.
To identify factors that might predict response to sunitinib in patients with renal cell carcinoma, we measured serum vascular endothelial growth factor (VEGF) and neutrophil gelatinase-associated lipocalin (NGAL) levels. A total of 85 patients were selected and, using the Motzer classification, 46 were assigned to the good- and 38 to the intermediate-risk groups. With univariate Cox analysis, both baseline serum VEGF and NGAL titers, determined by enzyme-linked immunosorbent assay, significantly predicted progression-free survival. For each biomarker, a threshold value was identified, which proved useful to classify patients into groups having titers above or below the thresholds. We then stratified patients according to the two dichotomous variables into good-, intermediate-, and poor-risk groups, and found significantly different progression-free survival rates ranging from 3.5 to 11.6 months. Both VEGF and NGAL maintained their predictive significance at bivariate analysis. Our study shows that serum levels of VEGF and NGAL are significant predictors of progression-free survival in patients with renal cell carcinoma treated with sunitinib.
Porta
Camillo
C
Medical Oncology, I.R.C.C.S. San Matteo University Hospital Foundation, Pavia I-27100, Italy. c.porta@smatteo.pv.it
Paglino
Chiara
C
De Amici
Mara
M
Quaglini
Silvana
S
Sacchi
Lucia
L
Imarisio
Ilaria
I
Canipari
Cinzia
C
D015415:Biomarkers / Q000097:blood; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D018572:Disease-Free Survival; D004797:Enzyme-Linked Immunosorbent Assay; D018093:Gelatinases / Q000378:metabolism; D006801:Humans; D007211:Indoles; D007668:Kidney / Q000378:metabolism / Q000473:pathology; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D054834:Lipocalins; D009369:Neoplasms / Q000188:drug therapy; D009504:Neutrophils / Q000378:metabolism / Q000473:pathology; D011758:Pyrroles; D000077210:Sunitinib; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism / Q000627:therapeutic use
D015415:Biomarkers; D007211:Indoles; D054834:Lipocalins; D011758:Pyrroles; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D018093:Gelatinases; D000077210:Sunitinib