Locomotion analysis of Sprague-Dawley rats before and after injecting 6-OHDA.
The hypothesis that changes in measured ground reaction forces and time parameters during locomotion can noninvasively detect Parkinsonism in unilateral 6-OH dopamine (6-OHDA) lesioned rats is tested. It was found that changes of seven locomotion parameters can be used to construct a logistic regression model with a detection sensitivity and specificity of over 90% as compared to non-lesioned rats. Comparisons between this model and other neurological and neuromuscular disorders are presented.
Department of Mechanical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250, United States.
Wenlong
W
Tang
Kim
K
McDowell
Mark
M
Limsam
Nagaraj K
NK
Neerchal
Paul
P
Yarowsky
Uri
U
Tasch
D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis; D000818:Animals; D001696:Biomechanical Phenomena; D004195:Disease Models, Animal; D008124:Locomotion; D016015:Logistic Models; D018482:Muscle, Skeletal / Q000293:injuries; D016627:Oxidopamine; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000175:diagnosis*; D011336:Probability; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D012680:Sensitivity and Specificity; D013997:Time Factors
D016627:Oxidopamine