[A prognostic analysis of N0-1M0 intralobar metastatic non-small cell lung cancer].
OBJECTIVE
To assess whether it is reasonable to downgrade intralobar metastatic non-small cell lung cancer from T4 disease through a prognostic analysis of N0-1M0 disease.


METHODS
A retrospective analysis was conducted to assess the survival of patients with intralobar metastatic non-small cell lung cancer with pathological N0-1M0 disease. The Kaplan-Meier method was used to calculate the patient survival.


RESULTS
Forty-six patients were included. The overall 5-year survival rate was 29.2% with a median survival of 53.0 months. The median survival was 24.0 months for patients with adenosquamous carcinoma; while for patients with other pathologic types, the median survival was 48 months. Adenosquamous carcinoma had a shorter survival time than other pathologic types (P = 0.003). The median survival time was 60.0 months for patients undergoing non-pneumonectomy resection and 24 months for patients undergoing pneumonectomy (P = 0.023).


CONCLUSIONS
It is reasonable to downgrade the T4 classification of non-small cell lung cancer with intralobar metastasis. However, pneumonectomy should be carried out with cautions. Adenosquamous carcinoma has a poor prognosis. Further study of a larger sample size is warranted.
Department of Thoracic Surgery, Sun Yat-sen University Cancer Center, State Key Laboratory for Cancer Research in South China, Guangzhou, China.
Hao-xian
HX
Yang
Xue
X
Hou
Peng
P
Lin
Tie-hua
TH
Rong
Hong
H
Yang
Jian-hua
JH
Fu
D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate