Nuclear poly(a)-binding proteins and nuclear degradation: take the mRNA and run?
Recent work from Lemay et al. (2010) in this issue of Molecular Cell reveals a role for a nuclear poly(A)-binding protein in promoting degradation of small nucleolar RNAs (snoRNAs) by the nuclear exosome.
Centre de Génétique Moléculaire, CNRS, 91190 Gif sur Yvette, France. libri@cgm.cnrs-gif.fr
Domenico
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Libri
D002467:Cell Nucleus / Q000378:metabolism*; D055354:Exosomes / Q000502:physiology; D017353:Gene Deletion; D008957:Models, Genetic; D039102:Poly(A)-Binding Proteins / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism*; D020537:RNA, Small Nucleolar / Q000378:metabolism; D012568:Schizosaccharomyces / Q000235:genetics*; D029702:Schizosaccharomyces pombe Proteins / Q000235:genetics / Q000502:physiology*
D039102:Poly(A)-Binding Proteins; D012333:RNA, Messenger; D020537:RNA, Small Nucleolar; D029702:Schizosaccharomyces pombe Proteins