CD56brightCD16- natural killer cells accumulate in the ovarian follicular fluid of patients undergoing in vitro fertilization.
CD56(bright)CD16(-) natural killer (NK) cells that express CXCR3 accumulate in the follicular fluid of patients with a good response to ovarian stimulation. It is conceivable that granulosa cells of good responders that express the chemokine CXCL10 recruit these NK cells to support follicular angiogenesis.
Division of Reproductive Sciences, Department of Obstetrics and Gynecology, University of Toronto, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto Centre for Advanced Reproductive Technology, Toronto, Ontario, Canada.
Ofer
O
Fainaru
Hagai
H
Amsalem
Yaakov
Y
Bentov
Navid
N
Esfandiari
Robert F
RF
Casper
D000328:Adult; D019002:CD56 Antigen / Q000378:metabolism*; D002465:Cell Movement; D054357:Chemokine CXCL10 / Q000378:metabolism; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000166:cytology*; D006107:Granulosa Cells / Q000378:metabolism; D006801:Humans; D007247:Infertility, Female / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism / Q000473:pathology*; D054315:Oocyte Retrieval; D054367:Receptors, CXCR3 / Q000378:metabolism; D017452:Receptors, IgG / Q000378:metabolism*
D019002:CD56 Antigen; C114753:CXCL10 protein, human; C515187:CXCR3 protein, human; D054357:Chemokine CXCL10; D054367:Receptors, CXCR3; D017452:Receptors, IgG