NF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS.
In this study, the role of NF-kappaB1 was examined during toxoplasmosis. While wildtype BALB/c mice generated protective responses, NF-kappaB1(-/-) mice developed Toxoplasmic encephalitis, characterized by increased parasite burden and necrosis in the brain. Susceptibility was primarily associated with a local decrease in the number of CD8(+) T cells and IFN-gamma production, while accessory cell function appeared intact in NF-kappaB1(-/-) mice. Consistent with these findings, T cell transfer studies revealed that NF-kappaB1(-/-) T cells provided SCID mice less protection than wildtype T cells. These results demonstrate an intrinsic role for NF-kappaB1 in T cell-mediated immunity to Toxoplasmagondii.
Harris
Tajie H
TH
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, 380 S University Ave, Philadelphia, PA 19104, United States.
Wilson
Emma H
EH
Tait
Elia D
ED
Buckley
Marie
M
Shapira
Sagi
S
Caamano
Jorge
J
Artis
David
D
Hunter
Christopher A
CA
D000818:Animals; D001921:Brain / Q000276:immunology / Q000469:parasitology / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology*; D007371:Interferon-gamma / Q000378:metabolism; D018655:Lymphocyte Count; D051379:Mice; D018345:Mice, Knockout; D016513:Mice, SCID; D052002:NF-kappa B p50 Subunit / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*; D014122:Toxoplasma / Q000276:immunology*; D016781:Toxoplasmosis, Cerebral / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology
D052002:NF-kappa B p50 Subunit; D012333:RNA, Messenger; C073701:Nfkb1 protein, mouse; D007371:Interferon-gamma