Diverted total synthesis leads to the generation of promising cell-migration inhibitors for treatment of tumor metastasis: in vivo and mechanistic studies on the migrastatin core ether analog.
A significantly simpler analog of the natural product migrastatin, termed migrastatin ether (ME), has been prepared and evaluated. Both in vivo and in vitro studies indicate that ME exhibits a concentration-dependent inhibitory effect on migration of breast cancer cells.
Cancer Biology and Genetics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, New York 10065, USA.
Thordur
T
Oskarsson
Pavel
P
Nagorny
Isaac J
IJ
Krauss
Lucy
L
Perez
Mihirbaran
M
Mandal
Guangli
G
Yang
Ouathek
O
Ouerfelli
Danhua
D
Xiao
Malcolm A S
MA
Moore
Joan
J
Massagué
Samuel J
SJ
Danishefsky
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001688:Biological Products / Q000737:chemistry*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002465:Cell Movement / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D004987:Ethers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D008968:Molecular Conformation; D009362:Neoplasm Metastasis / Q000188:drug therapy* / Q000473:pathology; D010881:Piperidones / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D001688:Biological Products; D004987:Ethers; D018942:Macrolides; D010881:Piperidones; C418199:migrastatin