[KIR/HLA ligand matching and acute rejection after kidney transplantation].
OBJECTIVE
To explore the effect of KIR/HLA ligand matching which mediates activated or inhibitory signal pathways on acute rejection (AR) after kidney transplantation.


METHODS
HLA and KIR genotype assortments were analyzed in 53 donor/recipient pairs of kidney transplantation. The recipients were divided into AR group (GI, n=19) and stable renal function group (GII, n=34) based on the early graft function. The impact of donor HLA, recipient KIR and distinct KIR/HLA class I ligand combinations on acute rejection after kidney transplantation was studied.


RESULTS
No significant differences were found in donor HLA-C1/2, HLA-A3, HLA-A11, or HLA-Bw4 between GI and GII groups. The frequency for KIR2DL2/2DS2 and KIR genotype assortment (AA) of the recipients in GI group were significantly lower than that in GII group (26.3% vs 55.9%, P=0.038; 31.6% vs 67.6%, P=0.011). The incidence of AR was significantly lower in donor HLA-C1/1 than in non-C1/1 (31.6% vs 46.7%, P>0.05), and lower in recipient KIR genotype assortment (AA) than in non-AA (20.7% vs 52.2%, P=0.011). A significant higher number of matches for the KIR2DL2/ HLA-C1 and KIR2DL3/HLA-C1 were observed in GII group (P=0.030, P=0.028).


CONCLUSIONS
Distinct KIR/HLA class I ligand combinations between the donor and recipient (such as KIR2DL2/ HLA-C1 and KIR2DL3/HLA-C1) may reduce the incidence of AR. A good KIR/HLA class I ligand matching will benefit the survival of the renal allograft.
Yu
Li-xin
LX
Department of Organ Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. yulixin1@medmail.com.cn
Xiao
Fei
F
Xiao
Lu-lu
LL
Luo
Min
M
Fu
Shao-jie
SJ
Wang
Yi-bin
YB
Miao
Yun
Y
D000293:Adolescent; D000328:Adult; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006085:Graft Survival / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology; D008024:Ligands; D008297:Male; D008875:Middle Aged; D054340:Receptors, KIR / Q000276:immunology*; D012189:Retrospective Studies; D015398:Signal Transduction; D055815:Young Adult
D006680:HLA Antigens; D008024:Ligands; D054340:Receptors, KIR