Why CD8+ T cells need diversity when growing up.
A thymus-specific subunit of the proteasome, beta5t, was previously described and shown to be essential for positive selection of CD8+ T cells. In this issue of Immunity, Nitta et al. (2010) suggest that beta5t is essential because it alters the specific peptide-MHC complexes displayed by cortical epithelial cells.
Center for Immunology, University of Minnesota, Minneapolis, MN 55414, USA. hogqu001@umn.edu
Kristin A
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Hogquist
Yan
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D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology*; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology; D046988:Proteasome Endopeptidase Complex / Q000276:immunology*; D013234:Stem Cells / Q000166:cytology / Q000276:immunology*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology*
D046988:Proteasome Endopeptidase Complex