Chemical and biological investigation of Araucaria heterophylla Salisb. resin.
Three labdane diterpenes, namely lambda-8(17),14-diene, 13-epicupressic acid, and 13-Oacetyl-13-epicupressic acid, were isolated from the resin collected from stem exudates of Araucaria heterophylla Salisb. (Araucariaceae). The isolated compounds were identified using different spectroscopic methods (1H NMR, 13C NMR, HMQC, HMBC and COSY). The resin extract showed antiulcerogenic activity against ethanol-induced stomach ulcers in Sprauge Dawely rats using ranitidine as standard. In addition, the resin and the isolated compounds showed variable cytotoxic activities against breast (MCF7) and colon (HCT116) cancer cell lines.
Department of Natural Products, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Kingdom of Saudi Arabia. abdelsattar@yahoo.com
Essam
E
Abdel-Sattar
Azza R Abdel
AR
Monem
Shahira M
SM
Ezzat
Ali M
AM
El-Halawany
Samar M
SM
Mouneir
D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000473:pathology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D018547:Plant Stems / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley; D012116:Resins, Plant / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D064028:Tracheophyta / Q000737:chemistry*; D014197:Trees / Q000737:chemistry
D004224:Diterpenes; D012116:Resins, Plant