Voltage-gated proton channels find their dream job managing the respiratory burst in phagocytes.
The voltage-gated proton channel bears surprising resemblance to the voltage-sensing domain (S1-S4) of other voltage-gated ion channels but is a dimer with two conduction pathways. The proton channel seems designed for efficient proton extrusion from cells. In phagocytes, it facilitates the production of reactive oxygen species by NADPH oxidase.
Department of Molecular Biophysics and Physiology, Rush University Medical Center, Chicago, Illinois, USA. tdecours@rush.edu
Thomas E
TE
DeCoursey
D000595:Amino Acid Sequence; D000818:Animals; D002463:Cell Membrane Permeability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015640:Ion Channel Gating; D007473:Ion Channels / Q000737:chemistry / Q000378:metabolism*; D008564:Membrane Potentials; D008954:Models, Biological; D008969:Molecular Sequence Data; D019255:NADPH Oxidases / Q000378:metabolism; D010586:Phagocytes / Q000201:enzymology / Q000378:metabolism*; D011487:Protein Conformation; D055503:Protein Multimerization; D011522:Protons; D017382:Reactive Oxygen Species / Q000378:metabolism; D016897:Respiratory Burst; D015398:Signal Transduction
D007473:Ion Channels; D011522:Protons; D017382:Reactive Oxygen Species; D019255:NADPH Oxidases