Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc.
The bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the 3-amino-8-azabicyclo[3.2.1]octane found in the CCR5 antagonist maraviroc.
Department of Medicinal Chemistry, Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, CA 94304, USA. remy.lemoine@roche.com
Rémy C
RC
Lemoine
Ann C
AC
Petersen
Lina
L
Setti
Thomas
T
Baldinger
Jutta
J
Wanner
Andreas
A
Jekle
Gabrielle
G
Heilek
André
A
deRosier
Changhua
C
Ji
David M
DM
Rotstein
D019380:Anti-HIV Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D053961:Azabicyclo Compounds / Q000737:chemistry*; D065100:CCR5 Receptor Antagonists; D045744:Cell Line, Tumor; D003510:Cyclohexanes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D023581:HIV Fusion Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D000077592:Maraviroc; D008956:Models, Chemical; D019713:Receptors, CCR5 / Q000378:metabolism; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
D019380:Anti-HIV Agents; D053961:Azabicyclo Compounds; D065100:CCR5 Receptor Antagonists; D003510:Cyclohexanes; D023581:HIV Fusion Inhibitors; D019713:Receptors, CCR5; D014230:Triazoles; D000077592:Maraviroc