[Chemotherapy with linezolid for chronic synthetic graft infection].
Infection of thoracic synthetic grafts is a serious problem, potentially leading to septicemia. Total removal of infected grafts might be too invasive for patients in poor general condition or who have long synthetic grafts. Effective and safe chemotherapy regimens are needed to control infection. A 75-year-old man with infected synthetic grafts of the ascending aorta, aortic arch, descending aorta, and thoracoabdominal aorta caused by methicillin-resistant Staphylococcus aureus was admitted to our hospital because of septicemia. He had previously received vancomycin for about 1 year at an outpatient clinic. The blood culture after admission was positive for vancomycin-intermediate Staphylococcus aureus. Linezolid was effective against septicemia, but caused side effects, such as blurred vision, severe diarrhea, and thrombocytopenia. Intermittent oral treatment with linezolid (1,200 mg/day) was then given for 7 days every 2 weeks. This treatment decreased the incidence of the side effects and had a beneficial effect on the infection.
Department of Cardiovascular Surgery, Fujisawa City Hospital, Fujisawa, Japan.
Motohiko
M
Goda
Ichiya
I
Yamazaki
Yoshimi
Y
Yano
Munetake
M
Masuda
D000081:Acetamides / Q000627:therapeutic use*; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001011:Aorta / Q000601:surgery; D001807:Blood Vessel Prosthesis; D002908:Chronic Disease; D006801:Humans; D000069349:Linezolid; D008297:Male; D023303:Oxazolidinones / Q000627:therapeutic use*; D016459:Prosthesis-Related Infections / Q000188:drug therapy*; D013203:Staphylococcal Infections
D000081:Acetamides; D000890:Anti-Infective Agents; D023303:Oxazolidinones; D000069349:Linezolid