Restoration of outer segments of foveal photoreceptors after resolution of central serous chorioretinopathy.
OBJECTIVE
To study morphologically and functionally the prognosis of damaged outer segments of the foveal photoreceptor layer in eyes with resolved central serous chorioretinopathy (CSC).


METHODS
We studied retrospectively the medical records of 70 patients (74 eyes) with resolved CSC. Optical coherence tomography was used to detect the junctions between inner and outer segments of the photoreceptors (IS/OS) as a hallmark of the integrity of the outer photoreceptor layer.


RESULTS
In 53 eyes (71.6%), the IS/OS line was clearly detected beneath the fovea immediately after resolution of the retinal detachment, with good visual acuity (VA). In the remaining 21 eyes (28.4%), however, the foveal IS/OS line could not be detected shortly after resolution of CSC, and VA was variable, ranging from 0.1 to 1.5 (median, 0.9). Of these 21 eyes, 15 had a follow-up examination with OCT, and in four the foveal IS/OS line was not detected at the follow-up and vision in these eyes remained poor. However, nine eyes showed recovery of the foveal IS/OS line during follow-up, and these eyes had substantial visual recovery.


CONCLUSIONS
Immediately after resolution of active CSC, although the IS/OS line cannot be detected beneath the fovea, it often shows restoration over time, with visual recovery, though in some eyes no restoration takes place and the prognosis remains poor.
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Yumiko
Y
Ojima
Akitaka
A
Tsujikawa
Kenji
K
Yamashiro
Sotaro
S
Ooto
Hiroshi
H
Tamura
Nagahisa
N
Yoshimura
D000208:Acute Disease; D000328:Adult; D000368:Aged; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D002908:Chronic Disease; D004396:Coloring Agents; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis / Q000503:physiopathology*; D006801:Humans; D007208:Indocyanine Green; D017075:Laser Coagulation; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D012008:Recurrence; D012163:Retinal Detachment / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy; D055214:Retinal Photoreceptor Cell Outer Segment / Q000502:physiology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology
D004396:Coloring Agents; D007208:Indocyanine Green