[Association between wnt signal pathway and post-infarction cardiac remodeling/rupture in aged mice].
OBJECTIVE
To observe the association between wnt signal pathway and post infarction left ventricular remodeling/rupture in mice with various ages.


METHODS
Three months-old (young group, n = 116) and 18 months-old (aged group, n = 116) male C57/BL mice were studied. Seventy mice underwent ligation of left coronary artery, 10 sham-operation and echocardiography and hemodynamics were performed 7 d post-infarction, 36 infarcted mice were used for detecting expression of dvl-1, beta-catenin and connexin 43 in left ventricular (LV) myocardium and infarction region at 3 d, 7 d, 14 d post infarction (n = 12 each).


RESULTS
Incidence of cardiac rupture was significantly higher in aged mice than in young mice (36.7% vs. 16.7%, P < 0.05) and degree of LV dilation and contractile dysfunction was significantly severer in aged mice than those in young mice post infarction. Expression of dvl-1, beta-catenin in left ventricle was upregulated in MI group compared with sham group (P < 0.05), expression of dvl-1 and beta-catenin in infarction region in MI 3d group in aged mice was significantly downregulated than in young mice (P < 0.05). Expression of connexin 43 is 2.15 fold higher in young sham mice than in aged sham mice (P < 0.05) and decreased significantly post infarction (P < 0.05). Expression of connexin 43 in infarction region in mice 3 d and 14 d post infarction was significantly lower in aged mice than in respective young mice (all P < 0.05).


CONCLUSIONS
Reductant activation of wnt signal pathway post infarction in aged mice might be responsible for increased incidence of cardiac rupture and aggravated remodeling.
Cardiac Centre in First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Ying
Y
Huang
Yi-Tong
YT
Ma
Yi-Ning
YN
Yang
Fen
F
Liu
Bang-Dang
BD
Chen
Xiao-Mei
XM
Li
D000375:Aging; D000818:Animals; D006341:Heart Rupture / Q000209:etiology*; D006352:Heart Ventricles; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism*; D015398:Signal Transduction; D020257:Ventricular Remodeling; D051153:Wnt Proteins / Q000378:metabolism
D051153:Wnt Proteins