[Effects of behind legs vibrations on erectile function in male rabbits].
OBJECTIVE
To study the effects of behind legs vibrations on erectile function in male rabbits through the concentration of plasma reproductive hormone and the expression of nitric oxide synthase (eNOS), endothelin-1 (ET-1) mRNA in vibrated male rabbits.


METHODS
30 male adult rabbits were assigned randomly to A group (vibration power: 3.02 m/s(2)), B group (vibration power: 6.13 m/s(2)), C group (vibration power: 12.26 m/s(2)) and control group. The concentration of expression of eNOS, ET-1 mRNA were measured with RT-PCR after rated for 30 days.


RESULTS
(1) Compared with 0 days vibration, after exposure to vibration for 10, 20, 30 days, the A, B, C group concentration of plasma T, LH are much lower (P < 0.05), the concentration of plasma E2 is much higher. (2) Compared with control group after exposed for 30 days, the expression of ET-1 mRNA [B group:(17.39 +/- 4.59) x 104; C group: (36.21 +/- 13.13) x 104 ] were much higher and expression of eNOS mRNA [A group: (19.11 +/- 6.83) x 104; B group: (11.86 +/- 3.15) x 104; C group: (4.68 +/- 3.26) x 104] was much lower, there were significant differences (P < 0.01).


CONCLUSIONS
The vibration of behind legs in rabbits resulted the concentration of plasma T, LH are much lower, the concentration of plasma E2 is much higher, increased the expression of eNOS mRNA, decreased the expression of eNOS mRNA, then vary the erectile function.
Zhu
Hai-Zhou
HZ
Jining Medical College, 272113 Jining, Shandong Province, China.
Liang
Lu-Nan
LN
Zhang
Zhao-Qiang
ZQ
Mao
Qing-Bo
QB
Lin
Li
L
D000818:Animals; D019332:Endothelin-1 / Q000235:genetics / Q000378:metabolism; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000235:genetics / Q000378:metabolism; D010410:Penile Erection; D010413:Penis / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D011817:Rabbits; D014732:Vibration / Q000009:adverse effects*
D019332:Endothelin-1; D012333:RNA, Messenger; D052250:Nitric Oxide Synthase Type III