Mutant mouse models: phenotypic relationships to domains of psychopathology and pathobiology in schizophrenia.
The present series of review articles seeks to elaborate how current findings in mutant mice may inform on the relationship between candidate genes and individual psychopathological and pathobiological aspects of schizophrenia. Each of the authors focuses on an overlapping selection of both well-characterized and emergent candidate genes, as identified through association and linkage studies and/or via their involvement in putative pathophysiological mechanisms, particularly those relating to dopaminergic and glutamatergic processes.
O'Tuathaigh
Colm M P
CM
Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, St Stephen's Green, Dublin 2, Ireland. cotuathaigh@rcsi.ie
Waddington
John L
JL
D000818:Animals; D001921:Brain / Q000473:pathology; D003072:Cognition Disorders / Q000235:genetics / Q000473:pathology / Q000523:psychology; D004252:DNA Mutational Analysis; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D056726:Genetic Association Studies; D008040:Genetic Linkage / Q000235:genetics; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains; D010641:Phenotype; D012559:Schizophrenia / Q000235:genetics* / Q000473:pathology*; D012565:Schizophrenic Psychology
D018698:Glutamic Acid; D004298:Dopamine