Obesity, inflammatory signaling, and hepatocellular carcinoma-an enlarging link.
There is growing evidence that obesity increases the risk of hepatocellular carcinoma (HCC). In a recent issue of Cell, Park et al. show that IL-6 and TNF signaling through activation of STAT3 are critical for obesity-promoted HCC development, underscoring the important role of inflammatory pathways in hepatocarcinogenesis.
Toffanin
Sara
S
Mount Sinai Liver Cancer Program, Division of Liver Diseases, Mount Sinai School of Medicine, New York, NY 10029, USA; Department of Experimental Oncology and Gastrointestinal Surgery and Liver Transplantation Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan 20133, Italy.
Friedman
Scott L
SL
Llovet
Josep M
JM