[The effect of dental plaque in cyclosporin A-induced gingival overgrowth].
OBJECTIVE
To evaluate the role of dental plaque in cyclosporin A(CsA)-induced gingival overgrowth.


METHODS
After extraction of half of the maxillary molars, twenty male Sprague-Dawley rats were assigned to a CsA-injection group (10mg/k x d) or a control group. Ten rats per group were sacrificed at week 4. The gingival width was measured under a stereomicroscope. Gingival specimens were taken, and the linear measurements were made with the help of software Image Pro-plus 6.0. The data was analyzed with SAS 6.12 software package.


RESULTS
The gingival width of the CsA group was significantly greater than the control group in both macroscopic analysis and histomorphometrical analysis (P<0.05).


CONCLUSIONS
Dental plaque seems not to be a essential but to be a co-factor for the CsA-induced gingival overgrowth.
Department of Periodontic, College of Stomatology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China. trili 2006@163.com
Li-li
LL
Li
Yuan-zheng
YZ
Yin
Zhong-kai
ZK
Wu
Yuan-jie
YJ
Shi
D000818:Animals; D016572:Cyclosporine; D003773:Dental Plaque; D005881:Gingiva; D019214:Gingival Overgrowth; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D016572:Cyclosporine