Molecular interaction between arsenic hydrate microcrystals and the cell-surface endopeptidase CD10 (neprilysin) - a possible link to the development of renal and cutaneous malignancies upon occupational exposure to arsenic compounds?
Arsenic poisoning has become a worldwide public health concern since arsenic is recognized as a human carcinogen although the detailed mechanisms of carcinogenesis related to arsenic exposure are not completely understood at present. In particular, the skin and the kidneys are prone to neoplastic transformation upon occupational exposure of the human body to inorganic arsenic compounds. The cell-surface endopeptidase CD10 is variably expressed in cutaneous and renal malignancies, and due to this expression profile, might theoretically be implicated in arsenic-induced skin and renal neoplasias. From the functional point of view, CD10 conveys important anti-tumorigenic effects brought about by the inactivation of neuropeptide growth factors implicated in cancer progression. Placing the focus on the structural composition of arsenic hydrate microcrystals encountered in the cellular microenvironment, the present hypothesis suggests so far neglected molecular interactions between arsenic microcrystals and membrane-bound CD10 to be implicated in arsenic-induced carcinogenesis.
Gunia
Sven
S
Institute of Pathology, HELIOS Clinic Bad Saarow, Charité-University Medicine Teaching Hospital, Pieskower Strasse 33, 15526 Bad Saarow, Germany. sven.gunia@helios-kliniken.de
D001149:Arsenates / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D007680:Kidney Neoplasms / Q000139:chemically induced*; D015260:Neprilysin / Q000737:chemistry*; D016273:Occupational Exposure; D012878:Skin Neoplasms / Q000139:chemically induced*
D001149:Arsenates; D015260:Neprilysin; C025657:arsenic acid