Transient hepatitis B surface antigen circulation after Infanrix-Hexa: a case report and review of the literature.
The authors describe the case of a 70-day-old boy who was mistakenly diagnosed as suffering from acute hepatitis B, when he presented with persistent unconjugated hyperbilirubinemia and transaminasemia and was found to be seropositive for the hepatitis B surface antigen. The antigenemia was transient and related to his recent immunization with Infanrix-Hexa. Caution is required during interpretation of a positive HBsAg test that is obtained within 28 days after vaccination against hepatitis B.
Mantadakis
Elpis
E
Department of Pediatrics, University General Hospital of Alexandroupolis, Democritus University of Thrace, Medical School, Alexandroupolis, Greece, emantada@med.duth.gr.
Thomaidis
Stavros
S
Efraimidou
Eugnosia-Nektaria
EN
Ramatani
Anna
A
Chatzimichael
Athanassios
A
D000208:Acute Disease; D003937:Diagnosis, Differential; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage* / Q000009:adverse effects*; D018073:Haemophilus Vaccines / Q000008:administration & dosage* / Q000009:adverse effects*; D006509:Hepatitis B / Q000097:blood / Q000175:diagnosis; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D006932:Hyperbilirubinemia / Q000276:immunology; D007223:Infant; D008297:Male; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage* / Q000009:adverse effects*; D013997:Time Factors; D000637:Transaminases / Q000097:blood; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000009:adverse effects
D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D018073:Haemophilus Vaccines; D006514:Hepatitis B Surface Antigens; D011054:Poliovirus Vaccine, Inactivated; D017778:Vaccines, Combined; D000637:Transaminases