Targeting tumor proteasome with traditional Chinese medicine.
The proteasome is a multicatalytic protease complex whose activity is required for the growth of normal or tumor cells. It has been shown that human cancer cells are more sensitive to proteasome inhibition than normal cells, indicating that the proteasome could be a target of chemotherapy. Studies suggest that traditional Chinese medicine (TCM) is an effective approach for cancer treatment. Here we reviewed several TCMs for their potential in treatment of cancer. This short review focuses mainly on the TCMs that potentially target the tumor cellular proteasome and NF-kappaB pathway whose activation is dependent on the proteasome activity.
The Prevention Program, Barbara Ann Karmanos Cancer Institute, and Department of Pathology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.
Huanjie
H
Yang
Jinbao
J
Liu
Q Ping
QP
Dou
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000494:pharmacology; D001593:Benzyl Compounds / Q000008:administration & dosage / Q000494:pharmacology; D003474:Curcumin / Q000008:administration & dosage / Q000494:pharmacology; D004224:Diterpenes / Q000008:administration & dosage / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D004852:Epoxy Compounds / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods*; D015394:Molecular Structure; D009285:Naphthoquinones / Q000008:administration & dosage / Q000494:pharmacology; D009369:Neoplasms / Q000188:drug therapy*; D053978:Pentacyclic Triterpenes; D010616:Phenanthrenes / Q000008:administration & dosage / Q000494:pharmacology; D010636:Phenols / Q000008:administration & dosage / Q000494:pharmacology; D046988:Proteasome Endopeptidase Complex / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects; D014315:Triterpenes / Q000008:administration & dosage / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D001593:Benzyl Compounds; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D004852:Epoxy Compounds; D009285:Naphthoquinones; D053978:Pentacyclic Triterpenes; D010616:Phenanthrenes; D010636:Phenols; D014315:Triterpenes; C071845:dendrophenol; C001899:triptolide; C016101:shikonin; D046988:Proteasome Endopeptidase Complex; D003474:Curcumin; C050414:celastrol; C012765:bakuchiol