Levocabastine nasal spray significantly improves perennial allergic rhinitis: a single-blind placebo-controlled study.
OBJECTIVE
The efficacy of levocabastine nasal spray for relieving the symptoms of perennial allergic rhinitis was compared with placebo in a single-blind study.


METHODS
Three hundred and thirty-five patients with moderate to severe perennial allergic rhinitis were randomized to three groups that were administered a high or low dose of levocabastine nasal spray or a placebo. Patients were not informed of their treatment. Efficacy was evaluated based on the changes of symptoms and rhinoscopy findings.


RESULTS
Significant improvement of symptoms was observed in both the high-dose and low-dose levocabastine groups compared with the placebo group. There were no significant differences of efficacy between the high-dose and low-dose levocabastine groups. There was also no significant difference in the occurrence of adverse effects among the three groups.


CONCLUSIONS
Levocabastine nasal spray is a safe and effective treatment for perennial allergic rhinitis.
Department of Otolaryngology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. ent-kimi@nms.ac.jp
Kimihiro
K
Okubo
Eiji
E
Uchida
Shoji
S
Nogami
D000281:Administration, Intranasal; D000328:Adult; D005260:Female; D039563:Histamine H1 Antagonists, Non-Sedating / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D015508:Nasal Obstruction / Q000188:drug therapy; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D016037:Single-Blind Method; D016896:Treatment Outcome
D039563:Histamine H1 Antagonists, Non-Sedating