Drug interactions of clinical importance among the opioids, methadone and buprenorphine, and other frequently prescribed medications: a review.
Drug interactions are a leading cause of morbidity and mortality. Methadone and buprenorphine are frequently prescribed for the treatment of opioid addiction. Patients needing treatment with these medications often have co-occurring medical and mental illnesses that require medication treatment. The abuse of illicit substances is also common in opioid-addicted individuals. These clinical realities place patients being treated with methadone and buprenorphine at risk for potentially toxic drug interactions. A substantial literature has accumulated on drug interactions between either methadone or buprenorphine with other medications when ingested concomitantly by humans. This review summarizes current literature in this area.
Department of Psychiatry, University of California, San Francisco, San Francisco, California, USA. elinore.mccance-katz@ucsf.edu
Elinore F
EF
McCance-Katz
Lynn E
LE
Sullivan
Srikanth
S
Nallani
D002047:Buprenorphine / Q000009:adverse effects* / Q000493:pharmacokinetics; D065690:Cytochrome P-450 CYP2D6 Inhibitors; D004347:Drug Interactions; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects; D008691:Methadone / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000494:pharmacology; D009293:Opioid-Related Disorders / Q000188:drug therapy; D055553:Prescription Drugs / Q000009:adverse effects; D019966:Substance-Related Disorders / Q000150:complications / Q000188:drug therapy
D065690:Cytochrome P-450 CYP2D6 Inhibitors; D013287:Illicit Drugs; D055553:Prescription Drugs; D002047:Buprenorphine; D008691:Methadone