Double-blind and placebo-controlled study of the effectiveness and safety of extracorporeal cardiac shock wave therapy for severe angina pectoris.
BACKGROUND
Low-energy shock wave (SW) therapy has improved myocardial ischemia in both a porcine model and in patients with severe angina pectoris.


RESULTS
To further confirm the effectiveness and safety of SW therapy, 8 patients with severe angina pectoris were treated with SW therapy in a double-blind, placebo-controlled and cross-over manner. SW therapy, but not placebo, significantly improved chest pain symptoms and cardiac function without any complications or adverse effects.


CONCLUSIONS
Extracorporeal cardiac SW therapy is an effective, safe and non-invasive therapeutic option for severe angina pectoris.
Kikuchi
Yoku
Y
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Ito
Kenta
K
Ito
Yoshitaka
Y
Shiroto
Takashi
T
Tsuburaya
Ryuji
R
Aizawa
Kentaro
K
Hao
Kiyotaka
K
Fukumoto
Yoshihiro
Y
Takahashi
Jun
J
Takeda
Morihiko
M
Nakayama
Masaharu
M
Yasuda
Satoshi
S
Kuriyama
Shinichi
S
Tsuji
Ichiro
I
Shimokawa
Hiroaki
H
D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000628:therapy*; D002637:Chest Pain / Q000628:therapy*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008096:Lithotripsy / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014464:Ultrasonic Therapy / Q000009:adverse effects / Q000379:methods*
D010919:Placebos