Plasma adiponectin concentration is strongly associated with VLDL-TG catabolism in postmenopausal women.
OBJECTIVE
To investigate associations between plasma adiponectin concentration and very-low density lipoprotein-triglyceride (VLDL-TG) secretion and catabolism in postmenopausal women.


RESULTS
This cross-sectional study included 30 postmenopausal women. Plasma adiponectin concentration was measured by ELISA. Insulin sensitivity was assessed by a 2-h euglycemic-hyperinsulinemic clamp. Fasting plasma glucose (FPG) and 2-hour plasma glucose (2hPG) were measured during an oral glucose tolerance test. The calculation of VLDL-TG fractional catabolic rate (FCR) and VLDL-TG total secretion rate (TSR) were based on the monoexponential decrease of TG-[²H₅] glycerol values obtained following the administration of a ²H₅-glycerol bolus. Plasma adiponectin concentration was negatively associated with VLDL-TG TSR (r=-0.50; p=0.005) and positively associated with VLDL-TG FCR (r=0.54; p<0.002). This latter association remained significant after further adjustments for insulin sensitivity, visceral adipose tissue, HDL-C, FPG and 2hPG concentrations. In a multivariate model including adiponectin, insulin sensitivity and 2hPG, plasma adiponectin level was the strongest correlate of VLDL-TG FCR.


CONCLUSIONS
Elevated plasma adiponectin concentration is associated with a favourable VLDL-TG metabolism.
Institute of Nutraceuticals and Functional Foods, Laval University, 2440 Hochelaga Blvd, Québec G1V 0A6, Canada.
A
A
Lapointe
A
A
Tchernof
B
B
Lamarche
M E
ME
Piché
J
J
Weisnagel
J
J
Bergeron
S
S
Lemieux
D052242:Adiponectin / Q000097:blood; D050154:Adiposity; D000368:Aged; D001786:Blood Glucose; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat; D007700:Kinetics; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008875:Middle Aged; D017698:Postmenopause; D014280:Triglycerides / Q000378:metabolism*
C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose; D008079:Lipoproteins, VLDL; D014280:Triglycerides