Pancreatoduodenectomy for ductal adenocarcinoma: implications of positive margin on survival.
OBJECTIVE
To assess the effect of R0 resection margin status and R0 en bloc resection in pancreatoduodenectomy outcomes.


METHODS
Retrospective medical record review.


METHODS
Mayo Clinic, Rochester, Minnesota.


METHODS
Patients who underwent pancreatoduodenectomy for pancreatic adenocarcinoma at our institution between January 1, 1981, and December 31, 2007, were identified and their medical records were reviewed.


METHODS
Median survival times.


RESULTS
A total of 617 patients underwent pancreatoduodenectomy. Median survival times after R0 en bloc resection (n = 411), R0 non-en bloc resection (n = 57), R1 resection (n = 127), and R2 resection (n = 22) were 19, 18, 15, and 10 months, respectively (P < .001). A positive resection margin was associated with death (P = .01). No difference in survival time was found between patients undergoing R0 en bloc and R0 resections after reexcision of an initial positive margin (hazard ratio, 1.19; 95% confidence interval, 0.87-1.64; P = .28).


CONCLUSIONS
R0 resection remains an important prognostic factor. Achieving R0 status by initial en bloc resection or reexcision results in similar long-term survival.
Department of Surgery, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA.
Javairiah
J
Fatima
Thomas
T
Schnelldorfer
Joshua
J
Barton
Christina M
CM
Wood
Heather J
HJ
Wiste
Thomas C
TC
Smyrk
Lizhi
L
Zhang
Michael G
MG
Sarr
David M
DM
Nagorney
Michael B
MB
Farnell
D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual; D010190:Pancreatic Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D016577:Pancreaticoduodenectomy; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome