Chiral bifunctional thiourea-catalyzed enantioselective Michael addition of ketones to nitrodienes.
Simple bifunctional thioureas, derived from the commercially available saccharides and chiral diamines, have been shown tunably to promote Michael-type addition of ketones to alpha,beta-gamma,delta-nitrodienes. The Michael adducts were obtained in good yields albeit with high enantioselectivites (84-99% ee). Furthermore, these products can be readily transformed into more useful molecules.
Ma
Hai
H
Department of Chemistry, Tianjin University, Tianjin 300072, China.
Liu
Kun
K
Zhang
Fa-Guang
FG
Zhu
Chuan-Le
CL
Nie
Jing
J
Ma
Jun-An
JA