Esophagitis caused by Candida guilliermondii in diabetes mellitus: first reported case.
Diabetic patients are at risk of acquiring esophageal infections such as those caused by members of the genus Candida. Here we describe a case in which Candida guilliermondii was isolated from the esophageal mucosa of a patient with uncontrolled diabetes mellitus. Due to inappropriate and inaccurate identification, the emergence of non-C. albicans Candida species as potential pathogens has been underestimated. This should be a cause of concern since C. guilliermondii is a normal component of human microbiota. The identity of the isolate in our case was confirmed by its characteristic morphophysiological features and amplification of rDNA using species-specific primers. Fluconazole therapy produced no improvement of the esophageal symptoms, and resistance of the etiologic agent was confirmed through in vitro susceptibility tests. This is thought to be the first documented case of C. guilliermondii esophagitis in a patient with diabetes mellitus.
Macêdo
Danielle P C
DP
Departamento de Micologia, Centro de Ciências Biológicas, Universidade Federal de Pernambuco, Rua Cardeal Arcoverde 116/203, Gracas, Recife-PE, Brazil. danielle_xande@yahoo.com.br
Oliveira
Neiva T
NT
Farias
Aline M A
AM
Silva
Vanessa K A
VK
Wilheim
Ana B
AB
Couto
Fabíola M
FM
Neves
Rejane P
RP
D000935:Antifungal Agents / Q000627:therapeutic use; D002175:Candida / Q000145:classification / Q000166:cytology / Q000235:genetics / Q000302:isolation & purification*; D002177:Candidiasis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D048909:Diabetes Complications / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D004941:Esophagitis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D008853:Microscopy; D008875:Middle Aged; D009092:Mucous Membrane / Q000382:microbiology; D016533:Mycological Typing Techniques; D017422:Sequence Analysis, DNA
D000935:Antifungal Agents; D004271:DNA, Fungal; D004275:DNA, Ribosomal; D015725:Fluconazole