Cu-catalyzed arylation of phenols: synthesis of sterically hindered and heteroaryl diaryl ethers.
Cu-catalyzed O-arylation of phenols with aryl iodides and bromides can be performed under mild condition in DMSO/K(3)PO(4) with use of picolinic acid as the ligand for copper. This method tolerates a variety of functional groups and is effective in the synthesis of hindered diaryl ethers and heteroaryl ethers.
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Debabrata
D
Maiti
Stephen L
SL
Buchwald
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D004987:Ethers / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D013237:Stereoisomerism
D004987:Ethers; D008024:Ligands; D010636:Phenols; D003300:Copper