The incidence, characteristics, and presentation of dengue virus infections during infancy.
Infants are a vulnerable and unique population at risk for dengue in endemic areas. This report describes the incidence and presenting clinical features of infant dengue virus (DENV) infections from a prospective community-based study performed between January 2007 and May 2009 in the Philippines. DENV3 was the predominant infecting serotype over a wide spectrum of disease severity, ranging from inapparent infection to dengue hemorrhagic fever (DHF). In 2007, the incidence of inapparent DENV infections during infancy was 103 per 1,000 persons person-years and 6-fold higher than symptomatic dengue. The age-specific incidence of infant DHF was 0.5 per 1,000 persons over the age of 3-8 months, and it disappeared by age 9 months. A febrile seizure, macular rash, petechiae, and lower platelet count were presenting clinical features associated with DENV infection among infants with acute undifferentiated febrile illnesses. Community-based studies can help to delineate the incidence rates, disease spectrum, and clinical features of DENV infections during infancy.
Departments of Microbiology and Medicine, Research Institute for Tropical Medicine, Manila, Philippines.
Rosario Z
RZ
Capeding
Job D
JD
Brion
Mercydina M
MM
Caponpon
Robert V
RV
Gibbons
Richard G
RG
Jarman
In-Kyu
IK
Yoon
Daniel H
DH
Libraty
D017677:Age Distribution; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D003715:Dengue / Q000175:diagnosis* / Q000453:epidemiology*; D003716:Dengue Virus / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D015994:Incidence; D007223:Infant; D008297:Male; D010679:Philippines / Q000453:epidemiology
D000914:Antibodies, Viral; D007075:Immunoglobulin M