Synthesis and cytotoxicity assessment of superparamagnetic iron-gold core-shell nanoparticles coated with polyglycerol.
Core-shell iron-gold (Fe@Au) nanoparticles were synthesized by a facile reverse micelle procedure and the effect of water to surfactant molar ratio (w) on the size, size distribution and magnetic properties of the nanoparticles was studied. MTT assay was utilized to evaluate the cell toxicity of the nanoparticles. To functionalize the particles for MRI imaging and targeted drug delivery, the particles were coated by polyglycerol through capping with thiol followed by polymerization of glycidol. The characteristics of the particles were examined by X-ray diffraction (XRD), transmission electron microscopy (TEM), vibrating sample magnetometer (VSM), UV-visible spectroscopy, and Fourier transform infrared spectroscopy (FT-IR). It was found that the size and size distribution of the nanoparticles increase by increasing the water to surfactant molar ratio (w). The particles were spherical in shape with a thin layer of gold. Complementary growth of the gold shell on the iron core was noticed. Meanwhile, two types of agglomeration including magnetic beads and magnetic colloidal nanocrystals clusters were observed dependent on the w-value. The magnetic measurement studies revealed the superparamagnetic behavior of the nanoparticles. MTT assay result indicated the synthesized nanoparticles are nontoxic that will be useful for biomedical applications.
Department of Materials Science and Engineering, Sharif University of Technology, P.O. Box 11365-9466, Tehran, Iran.
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Jafari
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Simchi
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Khakpash
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D020099:Coated Materials, Biocompatible; D003102:Colloids; D016503:Drug Delivery Systems; D005990:Glycerol; D006046:Gold; D006801:Humans; D007501:Iron; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D008422:Materials Testing; D051379:Mice; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D057145:Nanoshells / Q000737:chemistry* / Q000633:toxicity* / Q000648:ultrastructure; D036103:Nanotechnology; D010316:Particle Size; D011108:Polymers; D013053:Spectrophotometry; D017550:Spectroscopy, Fourier Transform Infrared; D013501:Surface-Active Agents; D014867:Water; D014961:X-Ray Diffraction
D020099:Coated Materials, Biocompatible; D003102:Colloids; D008823:Micelles; D011108:Polymers; D013501:Surface-Active Agents; D014867:Water; C043941:polyglycerol; D006046:Gold; D007501:Iron; D005990:Glycerol