HIV-tuberculosis coinfection in Southern California: evaluating disparities in disease burden.
OBJECTIVE
We sought to understand tuberculosis (TB) and HIV coinfection trends in San Diego County, California, and to identify associations between sociodemographic risk factors and TB and HIV coinfection.


METHODS
We analyzed TB surveillance data from 1993 through 2007. TB cases were grouped by HIV status: positive, negative, or unknown. We used Poisson regression to estimate trends and tested associations between TB and HIV coinfection and sociodemographic risk factors with polychotomous logistic regression.


RESULTS
Of 5172 TB cases, 8.8% were also infected with HIV. Incidence of coinfected cases did not change significantly over the period studied, but the proportion of cases among Hispanics increased significantly, whereas cases among non-Hispanic Whites and Blacks decreased. TB cases with HIV coinfection were significantly more likely to be Hispanic, male, injection drugs users, and aged 30 to 49 years, relative to cases with TB disease only.


CONCLUSIONS
The burden of TB and HIV in San Diego has shifted to Hispanics in the last decade. To address this health disparity, binational TB and HIV prevention efforts are needed.
Department of Medicine, Division of Global Public Health, University of California San Diego School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093-0507, USA. trodwell@ucsd.edu
Timothy C
TC
Rodwell
Richard F W
RF
Barnes
Marisa
M
Moore
Steffanie A
SA
Strathdee
Annie
A
Raich
Kathleen S
KS
Moser
Richard S
RS
Garfein
D000328:Adult; D000368:Aged; D002140:California / Q000453:epidemiology; D015897:Comorbidity / Q000639:trends*; D017281:Cost of Illness; D015658:HIV Infections / Q000453:epidemiology*; D054624:Health Status Disparities; D006801:Humans; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance; D012189:Retrospective Studies; D012307:Risk Factors; D012923:Social Class; D014376:Tuberculosis / Q000453:epidemiology*