Fulminant infectious mononucleosis and recurrent Epstein-Barr virus reactivation in an adolescent.
We describe a unique case of fulminant infectious mononucleosis and recurrent Epstein-Barr virus reactivation presenting in an adolescent. Detailed assays of Epstein-Barr virus-specific T cell immunity revealed defects in the patient's T cell receptor signalling pathway characterized by a lack of interleukin-2 and CD25 expression, which may have contributed to her clinical course. Allogeneic stem cell transplantation reversed the clinical and laboratory phenotype.
Nourse
Jamie P
JP
Clinical Immunohaematology Laboratory, Queensland Institute of Medical Research, Brisbane, Australia.
Jones
Kimberley
K
Dua
Ujjwal
U
Runnegar
Naomi
N
Looke
David
D
Schmidt
Chris
C
Tey
Siok-Keen
SK
Kennedy
Glen
G
Gandhi
Maher K
MK
D000293:Adolescent; D002648:Child; D004854:Herpesvirus 4, Human / Q000276:immunology* / Q000302:isolation & purification*; D006801:Humans; D007244:Infectious Mononucleosis / Q000175:diagnosis* / Q000276:immunology* / Q000628:therapy; D007376:Interleukin-2 / Q000172:deficiency; D053645:Interleukin-2 Receptor alpha Subunit / Q000172:deficiency; D011948:Receptors, Antigen, T-Cell / Q000172:deficiency; D012008:Recurrence; D033581:Stem Cell Transplantation; D013601:T-Lymphocytes / Q000276:immunology; D014775:Virus Activation; D055815:Young Adult
D007376:Interleukin-2; D053645:Interleukin-2 Receptor alpha Subunit; D011948:Receptors, Antigen, T-Cell