Aeromonas caviae strain induces Th1 cytokine response in mouse intestinal tract.
Aeromonas caviae has been associated with human gastrointestinal disease. Strains of this species typically lack virulence factors (VFs) such as enterotoxins and hemolysins that are produced by other human pathogens of the Aeromonas genus. Microarray profiling of murine small intestinal extracts, 24 h after oral infection with an A. caviae strain, provides evidence of a Th1 type immune response. A large number of gamma-interferon (gamma-IFN) induced genes are up-regulated as well as several tumor necrosis factor-alpha (TNF-alpha) transcripts. Aeromonas caviae has always been considered an opportunistic pathogen because it lacks obvious virulence factors. This current effort suggests that an A. caviae strain can colonize the murine intestinal tract and cause what has been described by others as a dysregulatory cytokine response. This response could explain why a number of diarrheal waterborne disease cases have been attributed to A. caviae even though it lacks obvious enteropathogenic properties.
Hayes
Samuel L
SL
United States Environmental Protection Agency, National Risk Management Research Laboratory, Water Supply/Water Resources Division, 26 W. Martin Luther King Dr, MS-387, Cincinnati, OH 45268, USA. hayes.sam@epa.gov
Lye
Dennis J
DJ
McKinstry
Craig A
CA
Vesper
Stephen J
SJ
D000333:Aeromonas / Q000276:immunology*; D000818:Animals; D016207:Cytokines / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology*; D016905:Gram-Negative Bacterial Infections / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology; D007421:Intestine, Small / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D018417:Th1 Cells / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma