Decreased endothelin-1 levels after acute consumption of red wine and de-alcoholized red wine.
BACKGROUND
Red wine consumption may influence on vasoconstrictive peptide endothelin-1 levels, and this may be one mechanism leading to improved vasodilation after red wine consumption. Endothelin-1 levels and their association with coronary epicardial diameter and flow rate, however, have not been studied in vivo after consumption of red wine and de-alcoholized red wine. The purpose of this randomized trial was to determine the acute effects of these beverages on endothelin-1 levels and compare them to coronary artery epicardial diameter and flow rate.


METHODS
Twenty-two healthy men consumed a high dose (8.1+/-0.9 dL) of alcohol-containing red wine and de-alcoholized red wine in a cross-over design at one sitting with a two-week washout period. Endothelin-1 levels were determined and coronary artery diameter and flow rate assessed using transthoracic echocardiography before and acutely after intervention.


RESULTS
Red wine and de-alcoholized red wine significantly decreased endothelin-1 levels (0.75+/-0.26 pg/mL to 0.61+/-0.20 pg/mL, p=0.002; 0.74+/-0.32 pg/mL to 0.63+/-0.24 pg/mL, p=0.04, respectively), but did not have a significant effect on epicardial diameter (1.1+/-0.3 mm vs. 1.1+/-0.3 mm, p=0.58; and 1.1+/-0.3 mm vs. 1.1+/-0.2 mm, p=0.10, respectively) or flow rate (7.8+/-4.0 mL/min to 6.4+/-3.6 mL/min, p=0.07; and 7.8+/-4.0 mL/min to 7.4+/-3.2 mL/min, p=0.53, respectively).


CONCLUSIONS
Red wine and de-alcoholized red wine decreased plasma endothelin-1 levels after acute consumption, but this change was not reflected in coronary epicardial diameters or flow rate.
Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. tuoski@utu.fi
Tuomas O
TO
Kiviniemi
Antti
A
Saraste
Terho
T
Lehtimäki
Jyri O
JO
Toikka
Markku
M
Saraste
Olli T
OT
Raitakari
Jaakko J
JJ
Hartiala
Jorma
J
Viikari
Juha W
JW
Koskenvuo
D003331:Coronary Vessels / Q000187:drug effects; D004311:Double-Blind Method; D004452:Echocardiography; D019332:Endothelin-1 / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects; D014920:Wine; D055815:Young Adult
D019332:Endothelin-1; D000431:Ethanol