Dietary and physical activity patterns in children with obstructive sleep apnea.
OBJECTIVE
To assess dietary and physical activity patterns and morning circulating blood levels of the orexigenic hormones ghrelin and visfatin in children with either obesity, obstructive sleep apnea (OSA), or both conditions.


METHODS
In this cross-sectional design, 5- to 9-year-old participants (n = 245) from the community were identified. After overnight polysomnography, caregivers filled out a food and physical activity questionnaire, and the child underwent a fasting blood draw for ghrelin and visfatin plasma levels.


RESULTS
Compared with control subjects, obese children with OSA ate 2.2-times more fast food, ate less healthy food such as fruits and vegetables, and were 4.2-times less frequently involved in organized sports. OSA was positively correlated with plasma ghrelin levels (R(2), 0.73; P < .0001), but not visfatin levels, particularly when obesity was present.


CONCLUSIONS
OSA and obesity in children may adversely impact dietary preferences and may be particularly detrimental to daily physical activity patterns. Furthermore, increased ghrelin levels support the presence of increased appetite and caloric intake in obese patients with OSA, which in turn may further promote the severity of the underlying conditions.
Division of Pediatric Sleep Medicine, Department of Pediatrics, and Kosair Children's Hospital Research Institute, University of Louisville, Louisville, KY, USA.
Karen
K
Spruyt
Oscar
O
Sans Capdevila
Laura D
LD
Serpero
Leila
L
Kheirandish-Gozal
David
D
Gozal
D001066:Appetite; D015992:Body Mass Index; D002648:Child; D004032:Diet; D015444:Exercise; D005260:Female; D054439:Ghrelin / Q000097:blood; D006801:Humans; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood; D009765:Obesity / Q000097:blood / Q000150:complications; D017286:Polysomnography; D020181:Sleep Apnea, Obstructive / Q000097:blood / Q000150:complications / Q000503:physiopathology*
D054439:Ghrelin; D054409:Nicotinamide Phosphoribosyltransferase