Mitogen activated protein kinase phosphatases and cancer.
Deregulation of cell signaling is a vital part of cancer development. The mitogen activated protein kinase (MAPK) family is involved in regulating both cell growth and cell death. This family of kinases is negatively regulated by mitogen activated protein kinase phosphatases (MKPs). MKPs are dual specificity phosphatases that target threonine and tyrosine residues that appear in a TXY motif. There are eleven members of the MKP family. Expression of MKPs has been shown to be altered in many different types of cancer. Most of what is known centers on MKP-1, MKP-2 and MKP-3. This review will focus on their role in cancer development and progression.
Haagenson
Kelly K
KK
Graduate Program in Cancer Biology, Wayne State University School of Medicine, Detroit, MI, USA.
Wu
Gen Sheng
GS
D016923:Cell Death; D049109:Cell Proliferation; D054638:Dual Specificity Phosphatase 1; D054637:Dual-Specificity Phosphatases; D005260:Female; D006801:Humans; D008297:Male; D054639:Mitogen-Activated Protein Kinase Phosphatases / Q000378:metabolism*; D020928:Mitogen-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology* / Q000209:etiology; D009423:Nervous System Neoplasms; D015398:Signal Transduction / Q000502:physiology
D020928:Mitogen-Activated Protein Kinases; D054639:Mitogen-Activated Protein Kinase Phosphatases; C517019:DUSP1 protein, human; D054638:Dual Specificity Phosphatase 1; D054637:Dual-Specificity Phosphatases