HELP for AML: methylation profiling opens new avenues.
There is growing evidence that aberrant gene expression in cancer is linked to epigenetic deregulation like promoter cytosine methylation in CpG-islands. In this issue of Cancer Cell, Figueroa et al. show that genome-wide promoter DNA methylation profiling reveals unique AML subgroups and methylation patterns that are associated with clinical outcome.
Bullinger
Lars
L
Department of Internal Medicine III, University of Ulm, 89081 Ulm, Germany.
Armstrong
Scott A
SA
D019175:DNA Methylation / Q000235:genetics*; D020869:Gene Expression Profiling; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*