Gastroenteritis with severe consequences: a case of sotalol-induced torsades de pointes.
We present a case of sotalol-induced prolongation of the QT-interval with torsades de pointes in an octogenarian who was hospitalized because of gastroenteritis causing prerenal acute renal failure. Subsequent accumulation of sotalol caused a severe prolongation of the QT-interval on the surface ECG and ultimately torsades de pointes with loss of consciousness. The patient was successfully treated with temporary cardiac pacing, intravenous magnesium sulfate and definitive withdrawal of sotalol. The electrophysiological basis of the pro-arrhythmic properties of sotalol is reviewed in brief, additional risk factors are identified and treatment is outlined.
Dept. of Cardiology, Antwerp University Hospital, Antwerp, Belgium. vincent.michiels@uza.be
Vincent
V
Michiels
Hielko
H
Miljoen
Christiaan
C
Vrints
D058186:Acute Kidney Injury / Q000209:etiology*; D000369:Aged, 80 and over; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001022:Aortic Valve Insufficiency / Q000188:drug therapy; D002034:Bumetanide / Q000009:adverse effects; D002304:Cardiac Pacing, Artificial; D003681:Dehydration / Q000209:etiology; D004232:Diuretics / Q000009:adverse effects; D004562:Electrocardiography; D005759:Gastroenteritis / Q000150:complications*; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008297:Male; D012121:Respiration, Artificial; D013015:Sotalol / Q000009:adverse effects* / Q000627:therapeutic use; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000628:therapy
D000889:Anti-Arrhythmia Agents; D004232:Diuretics; D002034:Bumetanide; D013015:Sotalol