[Empirical study on nano-fluorouracil-coated intraocular lens inhibiting posterior capsule opacification].
OBJECTIVE
To prepare nano-fluorouracil-coated intraocular lens (IOL) and to investigate its effect and feasibility of inhibiting posterior capsule opacification (PCO) of rabbit.


METHODS
Nano-fluorouracil is cross linked with IOL with the technology of energy-loaded particle beam. Forty New Zealand white rabbits were medially divided into 2 groups named group A and B randomly. All the crystalline lens of the left eyes were emulsified and evacuated of by the same operator, and then different treatment in different groups. In group A, the control group, the Polymethylmethacrylate (PMMA) IOLs were implanted. In group B, the nano-fluorouracil-coated IOLs were implanted. Slit-lamp-micrographscopy, histopathologyscopy and electron-microscopy were performed when 4 weeks after the operations.


RESULTS
The incidence rate and severity degree of PCO in control group is higher than the other group. The inflammatory reaction of anterior segment of the left eyes were remarkably occurred in group A. While almost no inflammatory reaction of anterior segment of the left eyes occurred in group B.


CONCLUSIONS
With implanting nano-fluorouracil-coated IOLs after phacoemulsification and evacuation of the crystalline lens can inhibit PCO actively and have slight toxic reaction and damage in the eyes.
Department of Ophthalmoloty, Changzheng Hospital, Shanghai 200003, China.
Yuan-Yuan
YY
Liu
Xiao
X
Huang
Rui-Li
RL
Wei
You
Y
Li
Jin-Wei
JW
Cheng
D000818:Animals; D002386:Cataract / Q000628:therapy*; D005472:Fluorouracil / Q000008:administration & dosage; D019654:Lens Implantation, Intraocular / Q000295:instrumentation* / Q000379:methods*; D007910:Lenses, Intraocular; D049329:Nanostructures; D011817:Rabbits
D005472:Fluorouracil