Primary cutaneous carcinosarcoma: dermoscopic and immunohistochemical features.
A 73-year-old man presented a 9-month history of an enlarging nodule on his right temple. Dermoscopy revealed a non-pigmented lesion with ulceration, fibrosis and pale globules. An excisional biopsy was carried out and histology showed a biphasic tumour with a basal cell carcinoma like epithelial component and a dermal undifferentiated sarcoma, with pleomorphic spindle cells and numerous osteoclast-like giant cells. Based on immunohistochemistry findings, a diagnosis of primary cutaneous carcinosarcoma was made and the patient underwent wide local excision.
UT Southwestern Medical Center, Skin Surgery and Oncology Clinic, 5323 Harry Hines Blvd., Dallas, TX 75390, USA. eupjohn@connexus.net.au
Edward
E
Upjohn
Anna
A
Braue
Andrew
A
Ryan
D000368:Aged; D001315:Australia; D002280:Basal Cell Carcinoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D002296:Carcinosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D046169:Dermoscopy; D015726:Giant Cells / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D010010:Osteoclasts / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery