[Prediction of the disease course in inflammatory bowel diseases].
Clinical presentation at diagnosis and disease course of both Crohn's disease (CD) and ulcerative colitis (UC) are heterogeneous and variable over time. During follow up, intestinal strictures or perforation may eventually develop at most patients with CD, and significant number of patients will undergo surgery. Much emphasis was laid in recent years on the determination of important predictive factors. Since early introduction of immunomodulators and/or biologicals might be justified in patients at risk for disease progression, so it is important to identify these patients as soon as possible. This review article summarizes the available literature on important clinical, endoscopic, fecal, serological/routine laboratory and genetic factors and hopefully will assist clinicians in the decision making of daily practice when choosing the treatment strategy for their patients with inflammatory bowel diseases.
Kiss
Lajos Sándor
LS
Semmelweis Egyetem, Altalános Orvostudományi Kar I. Belgyógyászati Klinika Budapest. kislakpet@bel1.sote.hu
Lakatos
Péter László
PL
D015415:Biomarkers / Q000378:metabolism; D003093:Colitis, Ulcerative / Q000175:diagnosis; D003424:Crohn Disease / Q000175:diagnosis; D018450:Disease Progression; D016099:Endoscopy, Gastrointestinal; D020022:Genetic Predisposition to Disease; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis* / Q000378:metabolism; D011237:Predictive Value of Tests; D011379:Prognosis
D015415:Biomarkers