Role of radiotherapy in the treatment of nasoethmoidal adenocarcinoma.
OBJECTIVE
To assess the efficacy of radiotherapy in the treatment of nasoethmoidal adenocarcinoma.


METHODS
Multicenter, retrospective study.


METHODS
Eleven French hospitals.


METHODS
The medical records of 418 patients who presented with nasoethmoidal adenocarcinoma from January 1, 1976, through December 31, 2001, were evaluated. A total of 324 patients were treated with a combination of surgery and radiotherapy, and 55 were treated with surgery only.


METHODS
Survival rates, disease recurrence, and postoperative complications.


RESULTS
The 5-year Kaplan-Meier survey revealed survival rates of 64.5% for the surgery-only group and 70.8% for the combined-treatment group. In the surgery-only group, 28 patients (51%) had disease recurrence (24 local, 2 regional, and 2 distant). Of the 55 patients in the combined-treatment group, 31 patients (56%) had disease recurrence (29 local, 1 regional, and 1 distant). Immediate postoperative complications in the combined-treatment group were hemorrhages in 2 patients, meningitis in 3 patients, and cerebrospinal fluid leakage in 4 patients, but no deaths occurred. In the surgery-only group, 1 patient had meningitis, 2 had cerebrospinal fluid leaking but no hemorrhage, and 5 died postoperatively.


CONCLUSIONS
The results of this retrospective study suggest that radiotherapy can be used to treat nasoethmoidal adenocarcinoma, but its usefulness should be confirmed with further prospective studies.
Choussy
Olivier
O
Otorhinolaryngology Department, Rouen University Hospital, France. olivier.choussy@chu-rouen.fr
Ferron
Christophe
C
Védrine
Pierre-Olivier
PO
Toussaint
Bruno
B
Liétin
Bénédicte
B
Marandas
Patrick
P
Babin
Emmanuel
E
De Raucourt
Dominique
D
Reyt
Emile
E
Cosmidis
Alain
A
Makeieff
Marc
M
Dehesdin
Danièle
D
D000230:Adenocarcinoma / Q000532:radiotherapy* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D005004:Ethmoid Bone; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010255:Paranasal Sinus Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D012189:Retrospective Studies; D012307:Risk Factors; D012888:Skull Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D016019:Survival Analysis