[Value of dynamic study of cytokines in serum and leukocytes in patients with acute leukemia].
A number of interleukins and iron metabolic parameters were studied in acute leukemia over time. Regulation of hemopoiesis and the cytokine network has been found to be impaired, which appears as the increased synthesis of ferritin and hepsidin by macrophages that are activated by imbalance in the cytokine network. A severe impairment of the parameters responsible for a regulatory process is shown to occur in leukemia. There is no complete normalization of these parameters during hematological remission, which is likely to lead to a further relapse of leukemic process.
Makeshova
A B
AB
Levina
A A
AA
Mamukova
Iu I
IuI
Melik-Nubarov
N S
NS
Tsibul'skaia
M M
MM
Savchenko
V G
VG
D000208:Acute Disease; D000380:Agranulocytosis / Q000097:blood / Q000139:chemically induced; D023181:Antimicrobial Cationic Peptides / Q000097:blood; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D002352:Carrier Proteins / Q000097:blood; D016207:Cytokines / Q000097:blood*; D005293:Ferritins / Q000097:blood; D058973:Folate Receptors, GPI-Anchored; D064451:Hepcidins; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000097:blood; D007378:Interleukins / Q000097:blood; D007938:Leukemia / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D007962:Leukocytes / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000097:blood; D044967:Serum; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D023181:Antimicrobial Cationic Peptides; D000970:Antineoplastic Agents; D002352:Carrier Proteins; D016207:Cytokines; D058973:Folate Receptors, GPI-Anchored; C497442:HIF1A protein, human; D064451:Hepcidins; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D007378:Interleukins; D011956:Receptors, Cell Surface; D014409:Tumor Necrosis Factor-alpha; D005293:Ferritins