Relationship of high-molecular-weight adiponectin levels to visceral fat accumulation in hemodialysis patients.
OBJECTIVE
High molecular weight adiponectin (HMW ADPN) plays an important role in the regulation of insulin resistance and atherogenic processes. However, the role of HMW ADPN remains to be determined in hemodialysis (HD) patients.


METHODS
We measured serum HMW ADPN in 49 HD patients (age: 62.4+/-12.0 years, time on HD: 8.4+/-6.4 years, male/female=30/19), and examined the association between HMW ADPN and visceral fat area (VFA) estimated by abdominal CT scans.


RESULTS
Serum HMW ADPN concentrations were weakly and inversely correlated with serum TG (r=-0.271, p=0.0598), but significantly and positively correlated with HDL cholesterol (r=0.392, p=0.0050). Serum HMW ADPN levels were positively correlated with BMI (r=0.472, p=0.0084) in male patients, and the HMW ADPN levels were positively correlated with serum levels of HDL cholesterol (r=0.514, p=0.0243) and TG (r=0.605, p=0.0061).The regression coefficient between VFA and HMW ADPN was -0.491 (p<0.003). Multiple stepwise regression analyses showed that VFA was the most significant and independent determinant of serum HMW ADPN concentration.


CONCLUSIONS
These findings suggest that HMW ADPN may be inversely associated with visceral fat accumulation in HD patients.
Department of Medicine, Kidney Center, Tokyo Women's Medical University, Tokyo.
Noriko
N
Tamei
Tetsuya
T
Ogawa
Hideki
H
Ishida
Yoshitaka
Y
Ando
Kosaku
K
Nitta
D052242:Adiponectin / Q000097:blood / Q000737:chemistry; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000209:etiology / Q000473:pathology; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D003920:Diabetes Mellitus / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000473:pathology*; D007676:Kidney Failure, Chronic / Q000473:pathology / Q000628:therapy; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000473:pathology; D008875:Middle Aged; D008970:Molecular Weight; D006435:Renal Dialysis; D012727:Sex Characteristics; D014057:Tomography, X-Ray Computed
C499918:ADIPOQ protein, human; D052242:Adiponectin; D008076:Cholesterol, HDL