Linear IgA disease: successful application of immunoadsorption and review of the literature.
Linear IgA disease (LAD) is an autoimmune subepidermal blistering disorder characterized by IgA autoantibodies at the dermal-epidermal junction. Conventional first-line treatments include dapsone with or without oral glucocorticosteroids. Various other therapeutic approaches have been used in refractory patients. Immunoadsorption (IA) has been previously successfully applied in severe and/or otherwise treatment-resistant IgG-mediated immunobullous disorders. Here, we report a patient with a severe generalized LAD in whom adjuvant tryptophan IA was associated with rapid healing of skin lesions. Our observation suggests that IA may also be a helpful adjuvant treatment option for severe LAD.
Kasperkiewicz
Michael
M
Department of Dermatology, University of Lübeck, Lübeck, Germany. michael.kasperkiewicz @ uk-sh.de
Meier
Markus
M
Zillikens
Detlef
D
Schmidt
Enno
E
D000328:Adult; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D001768:Blister / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D002990:Clobetasol / Q000627:therapeutic use; D003622:Dapsone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007163:Immunosorbent Techniques; D011239:Prednisolone / Q000627:therapeutic use; D016896:Treatment Outcome; D014364:Tryptophan / Q000737:chemistry
D007070:Immunoglobulin A; D014364:Tryptophan; D003622:Dapsone; D011239:Prednisolone; D002990:Clobetasol