Adult neurogenesis is unaffected by a functional knock-out of MHC class I in mice.
The major histocompatibility complex (MHC) class I has a role in the regulation of immune responses and has been implicated recently in neural plasticity and neurogenesis. We therefore sought to investigate in functional MHC class I knockout mice, transporter associated with antigen processing 1 (TAP1) KO, whether there are alterations in adult neurogenesis. We found no significant differences in cell proliferation or neurogenesis in either the dentate gyrus or subventricular zone, in TAP1 KO versus wild-type mice at several different time points. Our results do not support a role for MHC class I in adult neurogenesis, although it may still have a role in the maturation and integration of newborn neurons.
Cambridge Centre for Brain Repair, Forvie Site, Cambridge, UK. rl342@cam.ac.uk
Rocio
R
Laguna Goya
Pam
P
Tyers
Roger A
RA
Barker
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics* / Q000378:metabolism*; D053687:Adult Stem Cells / Q000502:physiology; D000375:Aging; D000818:Animals; D001007:Anxiety / Q000235:genetics / Q000378:metabolism; D001921:Brain / Q000254:growth & development / Q000502:physiology; D049109:Cell Proliferation; D018891:Dentate Gyrus / Q000254:growth & development / Q000502:physiology; D005805:Genes, MHC Class I; D018782:Maze Learning / Q000502:physiology; D008568:Memory / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D055495:Neurogenesis / Q000235:genetics* / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D013028:Space Perception / Q000502:physiology; D055153:Stem Cell Niche / Q000254:growth & development / Q000502:physiology
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters; C486171:Tap1 protein, mouse