Recent advances on platensimycin: a potential antimicrobial agent.
Platensimycin, an active metabolite of Streptomyces platensis, was initially discovered by a combination of RNA interferin induced gene-silencing and library screening to microbial extracts. Platensimycin selectively inhibits beta - ketoacyl-acyl carrier protein (ACP) synthase II (FabF) that is recognized as an effective broad-spectrum antibiotic against drug-resistant microorganism strains. Its novel scaffold and extraordinary antibacterial activity have drawn great attentions in recent years. So far, a number of synthetic strategies have been explored for the total synthesis of platensimycin. Moreover, many analogues have been investigated in terms of structure-activity relationships (SAR). This review provides a detailed overview of updated studies on platensimycin, focusing on various total and formal synthetic strategies, development of analogues, and the structure-activity relationships.
Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, China.
Xiaoyun
X
Lu
Qidong
Q
You
D000218:Adamantane / Q000737:chemistry / Q000494:pharmacology*; D062365:Aminobenzoates / Q000737:chemistry / Q000494:pharmacology*; D000813:Anilides / Q000737:chemistry / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D062365:Aminobenzoates; D000813:Anilides; D000900:Anti-Bacterial Agents; D000218:Adamantane; C510909:platensimycin