Maternal serum anti-Mullerian hormone level is not superior to chronological age in predicting Down syndrome pregnancies.
OBJECTIVE
To compare the difference in maternal serum anti-Mullerian hormone (AMH) level between Down syndrome pregnancies and unaffected pregnancies, and to evaluate its performance as a screening marker for Down syndrome pregnancy.


METHODS
A total of 145 pregnancies affected by foetal Down syndrome and 290 unaffected controls matched with maternal age and gestational age were selected, and their archived first or second trimester serum retrieved for AMH assay.


RESULTS
There was no significant difference in maternal serum AMH level between pregnancies affected and unaffected by foetal Down syndrome. Our first trimester serum samples had higher AMH concentration compared to second trimester samples.


CONCLUSIONS
Maternal serum AMH level, as a marker of ovarian age, is not superior to chronological age in predicting Down syndrome pregnancies. Despite the cross-sectional nature of our study, the variation of maternal serum AMH concentration with gestational age warrants further investigation.
Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital and Tsan Yuk Hospital, 102 Pokfulam Road, Hong Kong, China. raymondli@hkucc.hku.hk
Hang Wun Raymond
HW
Li
Pui Wah
PW
Hui
Mary Hoi Yin
MH
Tang
Elizabeth Tak Kwong
ET
Lau
William Shu Biu
WS
Yeung
Pak Chung
PC
Ho
Ernest Hung Yu
EH
Ng
D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D004314:Down Syndrome / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D008403:Mass Screening; D008423:Maternal Age; D008875:Middle Aged; D011247:Pregnancy / Q000097:blood*; D055815:Young Adult
D015415:Biomarkers; D054304:Anti-Mullerian Hormone