Blood product replacement for postpartum hemorrhage.
Hemorrhage requiring blood transfusion is a common occurrence in obstetrics. This article reviews each step in the transfusion process, including laboratory preparation of blood, indications for various blood components, complications of blood transfusion, massive transfusion, and alternatives to homologous blood. Current thinking regarding transfusion-related acute lung injury, transfusion-related immunomodulation, early use of plasma for massive transfusion, and the use of adjuvant agents such as activated recombinant factor VII are also discussed.
Department of Anesthesiology, University of Colorado at Denver Health Sciences Center, Aurora, Colorado, USA. Fuller@ucdenver.edu
Andrea J
AJ
Fuller
Brenda A
BA
Bucklin
D001803:Blood Transfusion / Q000379:methods*; D015942:Factor VIIa / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006473:Postpartum Hemorrhage / Q000175:diagnosis / Q000628:therapy*; D011247:Pregnancy; D011994:Recombinant Proteins / Q000627:therapeutic use; D065227:Transfusion Reaction
D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa