Targeted drug delivery of Rifampicin to the lungs: formulation, characterization, and stability studies of preformed aerosolized liposome and in situ formed aerosolized liposome.
OBJECTIVE
This study aimed at the preparation and characterization of preformed and in situ formed liposomes for sustained delivery to the lungs.


METHODS
Two different liposome formulations were prepared and subjected to characterization of physical parameters and drug release profile (% cumulative drug release and % drug retained). Formulations were then subjected to accelerated stability studies as per ICH guidelines.


RESULTS
In situ formed liposome showed better sustained release profile than the preformed liposome as it released sufficient amount of drug while retaining considerable amount of drug. Upon subjection to accelerated conditions for 60 days, preformed liposome lost the objective of being controlled release formulation.
Gaur
Praveen Kumar
PK
Department of Pharmaceutics, I.T.S. Paramedical (Pharmacy) College, Muradnagar, Uttar Pradesh, India. gaurmpharm@rediffmail.com
Mishra
Shikha
S
Gupta
Vipin Bihari
VB
Rathod
Mahendra Singh
MS
Purohit
Suresh
S
Savla
Bhavin A
BA
D000336:Aerosols; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D008081:Liposomes; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D012293:Rifampin / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics
D000336:Aerosols; D008081:Liposomes; D012293:Rifampin