Fungal secretome database: integrated platform for annotation of fungal secretomes.
BACKGROUND
Fungi secrete various proteins that have diverse functions. Prediction of secretory proteins using only one program is unsatisfactory. To enhance prediction accuracy, we constructed Fungal Secretome Database (FSD).


METHODS
A three-layer hierarchical identification rule based on nine prediction programs was used to identify putative secretory proteins in 158 fungal/oomycete genomes (208,883 proteins, 15.21% of the total proteome). The presence of putative effectors containing known host targeting signals such as RXLX [EDQ] and RXLR was investigated, presenting the degree of bias along with the species. The FSD's user-friendly interface provides summaries of prediction results and diverse web-based analysis functions through Favorite, a personalized repository.


CONCLUSIONS
The FSD can serve as an integrated platform supporting researches on secretory proteins in the fungal kingdom. All data and functions described in this study can be accessed on the FSD web site at http://fsd.snu.ac.kr/.
Choi
Jaeyoung
J
Fungal Bioinformatics Laboratory, Seoul National University, Seoul 151-921, Korea.
Park
Jongsun
J
Kim
Donghan
D
Jung
Kyongyong
K
Kang
Seogchan
S
Lee
Yong-Hwan
YH
D019295:Computational Biology; D030562:Databases, Protein; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D005658:Fungi / Q000235:genetics*; D016681:Genome, Fungal; D023281:Genomics / Q000379:methods; D020543:Proteome / Q000235:genetics*; D014584:User-Computer Interface
D005656:Fungal Proteins; D020543:Proteome