Language and brain volumes in children with epilepsy.
In this study the relationship between language skill and frontotemporal volumes was compared in 69 medically treated subjects with epilepsy and 34 healthy children, aged 6.1-16.6 years. Also, whether patients with linguistic deficits had abnormal volumes and atypical associations between volumes and language skills in these brain regions was determined. The children underwent language testing and MRI scans at 1.5 T. Brain tissue was segmented and frontotemporal volumes were computed. Higher mean language scores were significantly associated with larger inferior frontal gyrus, temporal lobe, and posterior superior temporal gyrus gray matter volumes in the epilepsy group and in the children with epilepsy with average language scores. Increased total brain and dorsolateral prefrontal gray and white matter volumes, however, were associated with higher language scores in the healthy controls. Within the epilepsy group, linguistic deficits were related to smaller anterior superior temporal gyrus gray matter volumes and there was a negative association between language scores and dorsolateral prefrontal gray matter volumes. These findings demonstrate abnormal development of language-related brain regions, and imply differential reorganization of brain regions subserving language in children with epilepsy with normal linguistic skills and in those with impaired language.
Caplan
Rochelle
R
Department of Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA. rcaplan@ucla.edu
Levitt
Jennifer
J
Siddarth
Prabha
P
Wu
Keng Nei
KN
Gurbani
Suresh
S
Shields
W Donald
WD
Sankar
Raman
R
D000293:Adolescent; D001921:Brain / Q000473:pathology*; D002648:Child; D002658:Developmental Disabilities / Q000209:etiology* / Q000473:pathology; D004827:Epilepsy / Q000150:complications* / Q000473:pathology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D007802:Language; D007805:Language Development Disorders / Q000209:etiology* / Q000473:pathology; D007806:Language Disorders / Q000209:etiology* / Q000473:pathology; D007807:Language Tests; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male