Treatment of heartburn and acid reflux associated with nausea and vomiting during pregnancy.
OBJECTIVE
In addition to suffering from nausea and vomiting of pregnancy, which is being treated with antiemetics, some of my pregnant patients complain of heartburn and acid reflux. Should these symptoms also be treated and, if so, which acid-reducing medications are safe for use during pregnancy?


CONCLUSIONS
Increased severity of nausea and vomiting of pregnancy is associated with the presence of heartburn and acid reflux. Antacids, histamine-2 receptor antagonists, and proton pump inhibitors can be used safely during pregnancy, as large studies have been published with no evidence of adverse fetal effects.
Law
Ruth
R
Leslie DanFaculty of Pharmacy, University of Toronto, Toronto, Canada.
Maltepe
Caroline
C
Bozzo
Pina
P
Einarson
Adrienne
A
D000863:Antacids / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000209:etiology; D006356:Heartburn / Q000188:drug therapy* / Q000209:etiology; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D048968:Morning Sickness / Q000150:complications; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D054328:Proton Pump Inhibitors / Q000627:therapeutic use
D000863:Antacids; D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors