High energy phosphate abnormalities normalize after antipsychotic treatment in schizophrenia: a longitudinal 31P MRS study of basal ganglia.
We reported increased high-energy phosphate metabolism in the basal ganglia of antipsychotic-naïve schizophrenia patients using (31)P Magnetic Resonance Spectroscopy (MRS). These patients were followed up for 1 year and and reassessed using (31)P MRS. Fourteen (8 males) patients with DSM-IV schizophrenia and 14 (11 males) healthy controls underwent (31)P MRS of sub-cortical structures (predominantly basal ganglia) twice (mean+/-S.D. interscan interval 1.15+/-0.17year) on a 1.5T scanner. Total scores on the Positive and Negative Syndrome Scale (PANSS) decreased significantly after treatment in schizophrenia patients. Patients had significantly lower mean PCr/ATP ratios than healthy controls at baseline but not during the follow-up. In patients, there was a significant positive correlation between the magnitude of improvement in PANSS total scores and the extent of change in the PCr/ATP ratio. Findings support the hypothesis that reduction of energy demand or induction of decreased energy-demanding processes might underlie the mechanism of action of antipsychotics in schizophrenia.
Jayakumar
Peruvumba N
PN
Department of Neuroimaging & Interventional Radiology, National Institute of Mental Health and Neurosciences, Bangalore, India.
Gangadhar
Bangalore N
BN
Venkatasubramanian
Ganesan
G
Desai
Sunali
S
Velayudhan
Latha
L
Subbakrishna
Dattathreya
D
Keshavan
Matcheri S
MS
D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001224:Aspartic Acid / Q000378:metabolism; D001479:Basal Ganglia / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism; D010759:Phosphorus Isotopes; D011569:Psychiatric Status Rating Scales; D011877:Radionuclide Imaging; D012559:Schizophrenia / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult
D014150:Antipsychotic Agents; D010759:Phosphorus Isotopes; D010725:Phosphocreatine; D001224:Aspartic Acid; D000255:Adenosine Triphosphate