[Current development of basic research and clinical use of small intestinal submucosa].
OBJECTIVE
To summarize the basic research and the clinical use of small intestinal submucosa (SIS), which is used as a degradable material for tissue repair.


METHODS
Recent literature concerning SIS at home and abroad was extensively reviewed, and current developments of the basic research and the clinical use of SIS were investigated.


RESULTS
SIS had many biological advantages in tissue repair, and was used to repair various tissue defects in animal trials. It had successful outcomes in many clinical trials to repair hernia, anal fistula and Peyronie diseases. And it also had good results at the early stage to treat dilation of the anastomosis, urethroplasty, hypospadias, and other diseases, however, the long-term follow-up was needed.


CONCLUSIONS
SIS is one kind of good material for tissue repair, and has promising future in the clinical use.
Department of Orthopaedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiaotong University, PR China.
Hao
H
Ding
Changqing
C
Zhang
D000818:Animals; D001672:Biocompatible Materials; D006801:Humans; D007413:Intestinal Mucosa; D007421:Intestine, Small; D012038:Regeneration
D001672:Biocompatible Materials