Low level of systemic autoimmunity in Western Australian multiple sclerosis patients.
Previous autoantibody (AAb) studies in multiple sclerosis MS have produced conflicting results. The objective of this study was to determine AAb frequency and association with the HLA-DRB1 genotype. Antinuclear antibody, antithyroid peroxidase and anti-aquaporin-4 assays and HLA-DRB1 genotyping were performed in 198 MS patients and 188 controls. There were no significant differences in AAb frequency or titres between MS and control subjects. AQP4-IgG was not found in any MS patients. There was no correlation between AAbs and HLA-DRB1 alleles. In conclusion, this study failed to confirm previous reports of increased AAbs in MS or to show an association between HLA-DRB1 genotype and the presence of AAbs.
Wei Qiu
Centre for Neuromuscular and Neurological disorders, University of Western Australia, Department of Neurology, Sir Charles Gairdner Hospital, Queen Elizabeth Medical Centre, Perth, Australia.
Bundell
Christine
C
Wu
Jing-Shan
JS
Castley
Alison
A
James
Ian
I
Hollingsworth
Peter
P
Christiansen
Frank
F
Carroll
William M
WM
Mastaglia
Frank L
FL
Kermode
Allan G
AG
D000974:Antibodies, Antinuclear / Q000097:blood; D051401:Aquaporin 4 / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D015551:Autoimmunity; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics / Q000276:immunology; D059811:HLA-DRB1 Chains; D006801:Humans; D016015:Logistic Models; D008297:Male; D009103:Multiple Sclerosis / Q000208:ethnology / Q000235:genetics / Q000276:immunology*; D010641:Phenotype; D018570:Risk Assessment; D012307:Risk Factors; D014904:Western Australia / Q000453:epidemiology; D044465:White People / Q000235:genetics
C496030:AQP4 protein, human; D000974:Antibodies, Antinuclear; D051401:Aquaporin 4; D001323:Autoantibodies; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C056626:thyroid microsomal antibodies