Combined mechanical and pharmacological approach to a thrombus-containing lesion.
Distal embolization during primary percutaneous coronary intervention for acute myocardial infarction is associated with impaired myocardial perfusion and poor outcome. Numerous pharmacological and mechanical strategies have been proposed to prevent and treat distal embolization. A successful combined mechanical and pharmacological approach to a large thrombus-containing lesion in patients with acute coronary syndrome is described. A review of the current literature regarding the drugs and devices available for the prevention and treatment of large thrombus burden has also been performed.
Division of Cardiology, Washington Hospital Center, Washington, D.C. 20010, USA.
Itsik
I
Ben-Dor
Augusto D
AD
Pichard
Ron
R
Waksman
D015906:Angioplasty, Balloon, Coronary; D000077144:Clopidogrel; D003131:Combined Modality Therapy; D017023:Coronary Angiography; D003326:Coronary Circulation; D003328:Coronary Thrombosis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D003331:Coronary Vessels / Q000473:pathology; D004108:Dilatation, Pathologic; D000077542:Eptifibatide; D005374:Filtration / Q000295:instrumentation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000628:therapy*; D010455:Peptides / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D017131:Thrombectomy / Q000379:methods*; D015912:Thrombolytic Therapy / Q000379:methods*; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives; D018084:Ultrasonography, Interventional
D010455:Peptides; D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D000077542:Eptifibatide; D013988:Ticlopidine