Altered function of the serotonin 1A autoreceptor and the antidepressant response.
In this issue of Neuron, Richardson-Jones et al. report on a novel genetic approach to conditionally and specifically dampen the function of the 5-HT(1A) autoreceptor in mice to study its role on the 5-HT system and on the antidepressant-like effect of the selective serotonin reuptake inhibitor (SSRI) fluoxetine.
University of Ottawa Institute of Mental Health Research, Ottawa, ON K1Z 7K4, Canada. pierre.blier@rohcg.on.ca <pierre.blier@rohcg.on.ca>
Pierre
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Blier
D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000378:metabolism* / Q000627:therapeutic use; D003865:Major Depressive Disorder / Q000188:drug therapy; D005473:Fluoxetine / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D009474:Neurons / Q000166:cytology / Q000378:metabolism; D044282:Receptor, Serotonin, 5-HT1A / Q000235:genetics / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*
D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine; D044282:Receptor, Serotonin, 5-HT1A; D012701:Serotonin