Acute ophthalmoparesis associated with human parvovirus B19 infection.
OBJECTIVE
Parvovirus B19 infection (PVB19) has been linked with a broad spectrum of clinical syndromes. In addition to erythema infectiosum and asymptomatic infection, other less common manifestations include transient aplastic crisis in patients with hemoglobinopathies, pure red cell aplasia and pancytopenia in immunocompromised persons, nonimmune hydrops fetalis, chronic arthritis, myocarditis, and hepatitis.


METHODS
Only 19% of patients had peripheral nervous system damage, mainly including brachial plexitis and carpal tunnel syndrome. Two cases of cranial nerves palsies have been described in children in the literature, including one case of peripheral facial nerve palsy and one case of velopalatine hemiparalysis. We report the first case of acute ophthalmoparesis associated with PVB19 infection.


RESULTS
We present a 40-year-old man with PVB19 with acute sixth cranial nerve palsy, diagnosed on the basis of serology and polymerase chain reaction carried out both on serum and cerebrospinal fluid.


CONCLUSIONS
Clinicians should be aware of this possible clinical presentation.
Department of Internal Medicine, Hospices Civils de Lyon, and University Claude Bernard, Lyon 1, France.
Julie
J
Le Scanff
Alain
A
Vighetto
Yahia
Y
Mekki
Anh Minh
AM
Nguyen
Jean-François
JF
Dufour
Christiane
C
Broussolle
Pascal
P
Seve
D000208:Acute Disease; D000328:Adult; D004279:DNA, Viral / Q000032:analysis*; D003937:Diagnosis, Differential; D016731:Erythema Infectiosum / Q000150:complications* / Q000821:virology; D006801:Humans; D008297:Male; D009886:Ophthalmoplegia / Q000175:diagnosis / Q000209:etiology*; D016732:Parvovirus B19, Human / Q000235:genetics*; D016133:Polymerase Chain Reaction; D014057:Tomography, X-Ray Computed
D004279:DNA, Viral