Acute myeloid leukemia after infliximab: a case report.
Concern has arisen regarding a possible increase in the risk of malignant diseases such as lymphoproliferative disorders in a patient taking TNF-alpha antagonists for the treatment of chronic inflammatory diseases. The evidence of a causal link remains unclear. We report a case of 60-year-old male patient who developed acute myeloid leukemia during infliximab therapy for ankylo-sing spondylitis.
Rheumatology Department, Henri Mondor Hospital, Paris XII University, Créteil, France.
F
F
Kemta Lekpa
K
K
Zahra
C
C
Pautas
S
S
Maury
X
X
Chevalier
P
P
Claudepierre
D000911:Antibodies, Monoclonal / Q000009:adverse effects*; D018501:Antirheumatic Agents / Q000009:adverse effects; D006801:Humans; D000069285:Infliximab; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D013167:Spondylitis, Ankylosing / Q000628:therapy*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
D000911:Antibodies, Monoclonal; D018501:Antirheumatic Agents; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab