[UPA/PAI-1: a tool for breast cancer treatment individualization. Biology, clinical implications and quantification assays].
The several options for therapy in breast cancer underline the difficulties to determine the reliable population which can be treated by a specific adjuvant therapy, and the population in which that therapy could generate morbidity, mortality, "medical surcharge" without prognosis improvement. This problem is particularly accurate in node-negative breast cancer patients. Adjuvant therapy has been proved to be more efficient, so a better definition of the prognosis and the response to adjuvant treatments could allow the selection of a sub-group of patients who can be spared chemotherapy. The quantification of the uPA/PAI-1 tumor content is one of the most relevant prognostic factors in this clinical setting. The integration of the uPA/PAI-1 prognostic information gathered in the multidisciplinary medical consensus meetings could be used to select the node-negative good/prognosis population in which chemotherapy could be avoided. This review will focus on the uPA/PAI-1 system, its biological role and its clinical implications in breast oncology. The different ways to analyse the uPA and PAI-1 content in tumor cells will be also presented and commented.
CRLC Val-d'Aurelle-Paul-Lamarque, laboratoire de biologie spécialisée, 34298 Montpellier cedex 05, France.
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PJ
Lamy
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Romieu
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Jacot
D014408:Biomarkers, Tumor / Q000502:physiology; D001943:Breast Neoplasms / Q000378:metabolism* / Q000628:therapy*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D009363:Neoplasm Proteins / Q000502:physiology*; D009364:Neoplasm Recurrence, Local; D017395:Plasminogen Activator Inhibitor 1 / Q000502:physiology*; D057285:Precision Medicine / Q000379:methods; D011379:Prognosis; D055293:Receptors, Urokinase Plasminogen Activator / Q000502:physiology; D014568:Urokinase-Type Plasminogen Activator / Q000502:physiology*
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D017395:Plasminogen Activator Inhibitor 1; D055293:Receptors, Urokinase Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator