[Changes of the concentration of serum ischemia modified albumin and high sensitivity C-reactive protein in type 2 diabetic patients with retinopathy].
OBJECTIVE
To explore the changes of the concentration of serum ischemia modified albumin (IMA) and high sensitivity C-reactive protein (hs-CRP) in type 2 diabetic patients with retinopathy (DR).


METHODS
The concentration of serum IMA and hs-CRP in DR patients were determined by ELISA and rate nephelometry and compared with those in 83 no-DR (NDR) patients and 72 controls. The concentration of serum IMA and hs-CRP in 40 proliferative diabetic retinopathy (PDR) patients were compared with those in 39 no-PDR (NPDR) patients. Data was evaluated using analysis of PPMS version 1.5.Results are expressed as means + or - standard deviation of the mean. Statistical comparisons were performed by student's t-test or one-way analysis of variance followed by Dunnett's multiple comparison test and the means compared each other using q test.


RESULTS
The serum IMA and hs-CRP concentration in DR patients were (46.51 + or - 13.29) microg/L, (4.27 + or - 2.24) mg/L. The serum IMA and hs-CRP concentration in NDR patients were (25.47 + or - 9.33) microg/L, (2.96 + or - 1.84) mg/L. The serum IMA and hs-CRP concentration in controls were (15.36 + or - 4.27) microg/L, (1.86 + or - 0.97) mg/L. The serum IMA and hs-CRP concentration in PDR patients were (54.72 + or - 15.61) microg/L, (6.34 + or - 3.53) mg/L. The serum IMA and hs-CRP concentration in NPDR patients were (38.35 + or - 11.27) microg/L, (3.28 + or - 1.77) mg/L. The serum IMA and hs-CRP concentration were significantly higher in DR patients than those in controls and NDR patients, the serum IMA and hs-CRP concentration in NDR patients were significantly higher than those in controls (F = 197.124, 34.561;q = 5.41-27.34; P < 0.01); the serum IMA and hs-CRP concentration were significantly higher in PDR patients than those in NPDR patients (t = 5.46, 4.89; P < 0.01); there was significant positive correlation between serum IMA concentration and hs-CRP concentration in DR patients (r = 0.617, P < 0.01).


CONCLUSIONS
The serum IMA and hs-CRP concentration were significantly high in DR patients, and were positively associated with the seriousness of DR, which may contribute to the development of DR.
Jia
Zhao-tong
ZT
Department of Endocrinology, The Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, China. jiazt@126.com
Liu
Cheng-yu
CY
Li
Hong
H
D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003930:Diabetic Retinopathy / Q000097:blood*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood; D008875:Middle Aged; D012709:Serum Albumin / Q000378:metabolism*
D012709:Serum Albumin; D002097:C-Reactive Protein