Multiple genes and locus interactions in susceptibility to vitiligo.
Refining the position of loci on chromosomes 7 and 9 previously linked with generalized vitiligo or vitiligo-associated autoimmune diseases presenting in families has been performed by high-density single-nucleotide polymorphism (SNP) genotyping. Investigation of the genetic interaction among these loci (and with a previously identified susceptibility gene, NLRP1, on chromosome 17) as risk factors for vitiligo demonstrates the complex nature of this disease.
Smith
Aaron G
AG
Melanogenix Group, Division of Molecular Genetics and Development, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Sturm
Richard A
RA
D002877:Chromosomes, Human; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D014820:Vitiligo / Q000453:epidemiology* / Q000235:genetics*