Photodynamic therapy in dermatology.
Photodynamic therapy (PDT) is a modern therapy modality, based upon the application of a photosensitizing agent like aminolevulinic acid, a physiological precursor of porphyrins, onto the tissue followed by illumination with light of the visible wavelength spectrum. During this oxygen-dependent reaction, reactive oxygen species (ROS) are generated that have immunomodulatory or cytotoxic effects. PDT shows excellent cosmetic results especially for its key indication in dermatology - the treatment of non-melanoma skin cancer. The associated pain and the low tissue penetration are the most frequent limiting factors of PDT. We review basic principles and recent developments in photosensitizers and light sources. Key oncological and non-oncological indications are presented as well.
Department of Dermatology, University Clinic of Regensburg, Germany. julia.steinbauer@klinik.uni-regensburg.de
Julia M
JM
Steinbauer
Stephan
S
Schreml
Elisabeth A
EA
Kohl
Sigrid
S
Karrer
Michael
M
Landthaler
Rolf-Markus
RM
Szeimies
D003880:Dermatology / Q000639:trends; D005858:Germany; D006801:Humans; D010778:Photochemotherapy / Q000379:methods* / Q000639:trends*; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D012871:Skin Diseases / Q000188:drug therapy*
D017319:Photosensitizing Agents