The effect of rowing on endothelial function and insulin action in healthy controls and in patients with type 2 diabetes.
Patients with type 2 diabetes (T2DM) have an increased risk for cardiovascular disease. We examined the effects of 8 weeks of home-based rowing training (heart rate corresponding to 65-70% of VO(2 peak) ) on endothelial function and glucose clearance (local and systemic effects) in male subjects with T2DM (n=9) and matched controls (n=8). Before and after training (30 min every other day), all subjects underwent sequential graded brachial artery infusions of non-insulin vasodilators (acetylcholine; sodium nitroprusside; adenosine). Forearm blood flow was improved by training in controls (without and with insulin: P=0.003 and 0.05, respectively) but not in subjects with T2DM. Likewise, whole body glucose clearance increased in response to training in controls (P=0.05) but not in T2DM. However, in both groups, the capacity for local forearm glucose extraction (controls: P=0.001; T2DM: P=0.002) and clearance (controls: P<0.001; T2DM: P=0.01) were positively affected by exercise. While the subjects with T2DM did not respond to the same degree as controls to 8 weeks of home-based exercise, there are clear benefits as illustrated by improvements in local glucose disposal. Training of higher intensity or duration may be required in order to elicit a response similar to controls.
Department of Biomedical Sciences, Center for Healthy Aging, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.
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DB
Olsen
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Scheede-Bergdahl
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Reving
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R
Boushel
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Dela
D001786:Blood Glucose / Q000502:physiology*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology* / Q000628:therapy; D042783:Endothelial Cells / Q000502:physiology*; D015444:Exercise / Q000502:physiology*; D005081:Exercise Therapy / Q000379:methods; D006801:Humans; D007328:Insulin / Q000502:physiology*; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D007328:Insulin