Mesenchymal stem-cell immunosuppressive capabilities: therapeutic implications in islet transplantation.
Mesenchymal stem cells (MSCs) are known to be capable of suppressing immune responses and offer therapeutic potential for achieving transplantation tolerance. This review will discuss the impacts of MSCs on transplant immunity and focus on the potential role of MSCs in protecting islet grafts from both rejection and autoimmune attack.
Transplantation Research Immunology Group, Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom. yunchuan.ding@nds.ox.ac.uk
Yunchuan
Y
Ding
Andrew
A
Bushell
Kathryn J
KJ
Wood
D016026:Bone Marrow Transplantation / Q000276:immunology; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000276:immunology / Q000601:surgery*; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D007165:Immunosuppression Therapy; D015994:Incidence; D007515:Islets of Langerhans / Q000276:immunology; D016381:Islets of Langerhans Transplantation / Q000276:immunology*; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000276:immunology*; D014184:Transplantation, Homologous / Q000276:immunology