The BCL-2 family reunion.
B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions.
Chipuk
Jerry E
JE
Department of Immunology, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Moldoveanu
Tudor
T
Llambi
Fabien
F
Parsons
Melissa J
MJ
Green
Douglas R
DR
D000595:Amino Acid Sequence; D017209:Apoptosis; D001343:Autophagy; D004721:Endoplasmic Reticulum / Q000378:metabolism; D051336:Mitochondrial Membranes / Q000378:metabolism / Q000648:ultrastructure; D008954:Models, Biological; D008969:Molecular Sequence Data; D005810:Multigene Family; D010539:Permeability; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D016415:Sequence Alignment; D015398:Signal Transduction
D019253:Proto-Oncogene Proteins c-bcl-2