Synthesis of substituted acridinyl pyrazoline derivatives and their evaluation for anti-inflammatory activity.
A rapid preparation of compounds (1-24), with the objective of discovering novel and potent anti-inflammatory agent. All the compounds exhibited anti-inflammatory and analgesic activities at the dose 50 mg/kg p.o. The compound 1-(2',4'-Chloroacridine-9'-yl)-3-(5'-pyridine-4-yl)-(1,3,4-oxadiazol-2-yl-thiomethyl)-pyrazole-5-one 24 showed better anti-inflammatory and analgesic activities at the three graded dose of 25, 50 and 100 mg/kg p.o.
Chandra
Trilok
T
Medicinal Chemistry Division, Department of Pharmacology, L.L.R.M. Medical College, Meerut (U.P.)-250004, India.
Garg
Neha
N
Lata
Suman
S
Saxena
K K
KK
Kumar
Ashok
A
D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D015394:Molecular Structure; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013237:Stereoisomerism
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011720:Pyrazoles