[Iodine deficiency in the prenatal period may form learning ability deficiency in the postnatal period].
The present study analysis the changes in learning ability of the progeny of rats suffered from iodine deficiency. Reduction of serum thyroxin in the mothers' blood during three months before mating and whole period of gestation to an average level of 4,7+/-0,6 ng/ml, significantly worsened the learning ability in progeny, and the reduction to 1,1+/-0,4 ng/ml - completely deprived progeny's learning ability. Passage of the maze for these animals was purely probabilistic in nature without any signs of learning We can conclude that the diet with very low iodine content results in a low level of thyroxin in maternal serum and neurological deficiency in progeny manifested by learning disability during maze testing. Addition of the iodine to the diet prevents development of mentioned neurological deficiency.
Tbilisi Medical Academy, Tbilisi State Medical University, I. Beritashvili Institute of Physiology.
N M
NM
Rustamov
I D
ID
Kvachadze
G L
GL
Bekaia
Z A
ZA
Sakvarelidze
N P
NP
Mitagvaria
D000818:Animals; D004032:Diet; D005260:Female; D007455:Iodine / Q000008:administration & dosage / Q000172:deficiency*; D007859:Learning Disabilities / Q000209:etiology*; D011247:Pregnancy; D039401:Prenatal Nutritional Physiological Phenomena; D051381:Rats; D013974:Thyroxine / Q000097:blood
D007455:Iodine; D013974:Thyroxine