Catechol-grafted poly(ethylene glycol) for PEGylation on versatile substrates.
We report on catechol-grafted poly(ethylene) glycol (PEG-g-catechol) for the preparation of nonfouling surfaces on versatile substrates including adhesion-resistant PTFE. PEG-g-catechol was prepared by the step-growth polymerization of PEO to which dopamine, a mussel-derived adhesive molecule, was conjugated. The immersion of substrates into an aqueous solution of PEG-g-catechol resulted in robust PEGylation on versatile surfaces of noble metals, oxides, and synthetic polymers. Surface PEGylation was unambiguously confirmed by various surface analytical tools such as ellipsometry, goniometry, infrared spectroscopy, and X-ray photoelectron spectroscopy. Contrary to existing PEG derivatives that are difficult-to-modify synthetic polymer surfaces, PEG-g-catechol can be considered to be a new class of PEGs for the facile surface PEGylation of various types of surfaces.
Department of Chemistry, Graduate School of Nanoscience & Nanotechonology, Molecular-level Interface Research Center, KAIST, Republic of Korea.
Hyukjin
H
Lee
Kang Dae
KD
Lee
Kyung Bo
KB
Pyo
Sung Young
SY
Park
Haeshin
H
Lee
D002396:Catechols / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods; D014965:X-Rays
D002396:Catechols; D011092:Polyethylene Glycols; C034221:catechol