Biomaterials/tissue interactions: possible solutions to overcome foreign body response.
In recent years, a variety of biomaterial implantable devices has been developed. Of particular significance to pharmaceutical sciences is the progress made on the development of drug/implantable device combination products. However, the clinical application of these devices is still a critical issue due to the host response, which results from both the tissue trauma during implantation and the presence of the device in the body. Accordingly, the in vivo functionality and durability of any implantable device can be compromised by the body response to the foreign material. Numerous strategies to overcome negative body reactions have been reported. The aim of this review is to outline some key issues of biomaterial/tissue interactions such as foreign body response and biocompatibility and biocompatibility assessment. In addition, general approaches used to overcome the in vivo instability of implantable devices are presented, including (a) biocompatible material coatings, (b) steroidal and nonsteroidal anti-inflammatory drugs, and (c) angiogenic drugs. In particular, strategies to overcome host response to glucose biosensors are summarized.
Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, Storrs, Connecticut 06269, USA.
Jacqueline M
JM
Morais
Fotios
F
Papadimitrakopoulos
Diane J
DJ
Burgess
D043925:Angiogenesis Inducing Agents / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001672:Biocompatible Materials / Q000009:adverse effects*; D015374:Biosensing Techniques; D001786:Blood Glucose / Q000032:analysis; D020099:Coated Materials, Biocompatible; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology; D016503:Drug Delivery Systems; D005549:Foreign-Body Reaction / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D020100:Hydrogels; D008422:Materials Testing; D042461:Vascular Endothelial Growth Factor A / Q000008:administration & dosage
D043925:Angiogenesis Inducing Agents; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001672:Biocompatible Materials; D001786:Blood Glucose; D020099:Coated Materials, Biocompatible; D020100:Hydrogels; D042461:Vascular Endothelial Growth Factor A; D003907:Dexamethasone