[CD5-positive B-cell prolymphocytic leukemia].
CD5 is a T-cell marker that is expressed in mature B cell malignancies and other B cell chronic lymphoproliferative disorders, but the biologic function of CD5 is unknown. We report a 68-year-old woman with B-cell prolymphocytic leukemia (B-PLL) expressing CD5 antigen. On admission, jaundice and hepatosplenomegaly were noted. Hematological examination demonstrated a platelet count of 2.8 x 10(4)/microl and a white blood cell count of 19,900/microl with 69% PLL cells. Surface marker analysis of the PLL cells was positive for CD5, CD19, CD20, sIgM, and was negative for CD23, and cyclin D1 was negative in immunostaining.
Department of Hematology, Social Insurance Shiga Hospital.
Tetsuya
T
Inoue
Masaaki
M
Yoshida
Kazuyoshi
K
Oowashi
Tadao
T
Yoshida
D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D018956:CD5 Antigens / Q000097:blood*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D054403:Leukemia, Prolymphocytic, B-Cell / Q000097:blood* / Q000175:diagnosis*; D007958:Leukocyte Count; D010976:Platelet Count
D014408:Biomarkers, Tumor; D018956:CD5 Antigens