Association of chest radiographic abnormalities with tuberculosis disease in asymptomatic HIV-infected adults.
METHODS
Francistown and Gaborone, Botswana.


OBJECTIVE
Chest radiography is used to screen for tuberculosis (TB) in asymptomatic persons living with the human immunodeficiency virus (PLWH) seeking isoniazid preventive therapy (IPT). We describe radiographic features in PLWH in a TB-endemic setting and identify features associated with TB disease.


METHODS
Asymptomatic PLWH seeking IPT under program conditions for a clinical trial between 2004 and 2006 received chest radiographs (CXRs) that were read using the standardized Chest Radiograph Reading and Recording System (CRRS). Clinical characteristics, including TB disease, were compared with the radiographic findings.


RESULTS
From 2732 screening CXRs, 183 had one or more abnormalities and were scored using CRRS, with 42% having infiltrates (36% upper lobes), 35% parenchymal fibrosis and 32% adenopathy. TB disease status was determined in 129 (70%) PLWH, of whom 22 (17%) had TB disease. TB disease was associated with upper lobe infiltrates (relative risk [RR] 3.0, 95%CI 1.5-6.2) and mediastinal adenopathy (RR 3.9, 95%CI 1.8-8.4). The sensitivity and specificity of either upper lobe infiltrates or mediastinal lymphadenopathy for TB disease were respectively 64% and 82%.


CONCLUSIONS
A combination of CXR features was useful for predicting TB disease in asymptomatic PLWH. CRRS should be used more frequently in similar studies.
BOTUSA, Gaborone, Botswana.
T
T
Agizew
M A
MA
Bachhuber
S
S
Nyirenda
V Z S A M
VZ
Makwaruzi
Z
Z
Tedla
R J
RJ
Tallaksen
J E
JE
Parker
J J
JJ
Mboya
T
T
Samandari
D017088:AIDS-Related Opportunistic Infections / Q000000981:diagnostic imaging*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000627:therapeutic use; D001902:Botswana / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008168:Lung / Q000473:pathology; D008206:Lymphatic Diseases / Q000000981:diagnostic imaging / Q000209:etiology; D008297:Male; D008400:Mass Chest X-Ray / Q000379:methods; D008477:Mediastinal Diseases / Q000000981:diagnostic imaging / Q000209:etiology; D008875:Middle Aged; D012680:Sensitivity and Specificity; D014376:Tuberculosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000517:prevention & control; D055815:Young Adult
D000995:Antitubercular Agents; D007538:Isoniazid