Role of the primary somatosensory cortex in motor learning: An rTMS study.
Somatosensation is thought to play an important role in skilled motor learning. The present study investigated how healthy adults learn a continuous implicit motor task when somatosensation is altered by 1 Hz repetitive transcranial magnetic stimulation (rTMS) delivered over the primary somatosensory cortex (S1). Twenty-seven right-handed participants enrolled in a two-part experiment. In Experiment 1, we verified that 20 min of 1 Hz rTMS over S1 disrupted cutaneous somatosensation (indexed by two-point discrimination) in the wrist/hand; the impact of 1 Hz rTMS on wrist proprioception (tested by limb-position matching) was variable. Sham rTMS had no effect on either measure. We exploited these effects in Experiment 2 by pairing either 1 Hz or sham rTMS with practice of a continuous tracking task over two separate sessions on different days. Implicit motor learning was indexed on a third, separate retention test day when no rTMS was delivered. Across practice in Experiment 2, both the 1 Hz and sham rTMS groups showed improved tracking performance; however, 1 Hz rTMS was associated with less accurate tracking and smaller improvements in performance. Importantly, at the no rTMS retention test the effects of altering sensation with stimulation over S1 were still evident in the persistently less accurate tracking behavior of the 1 Hz rTMS group. The current study shows that disruption of somatosensation during task practice impairs the magnitude of change associated with motor learning, perhaps through the development of an inaccurate internal model.
Vidoni
E D
ED
Department of Neurology, University of Kansas Medical Centre, Kansas City, KS, USA.
Acerra
N E
NE
Dao
E
E
Meehan
S K
SK
Boyd
L A
LA
D000328:Adult; D005260:Female; D006225:Hand / Q000502:physiology; D006801:Humans; D007858:Learning / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology*; D009483:Neuropsychological Tests; D011434:Proprioception / Q000502:physiology; D017603:Signal Detection, Psychological / Q000502:physiology; D012879:Skin Physiological Phenomena; D013003:Somatosensory Cortex / Q000502:physiology*; D013997:Time Factors; D055698:Touch Perception / Q000502:physiology; D050781:Transcranial Magnetic Stimulation / Q000379:methods; D014953:Wrist / Q000502:physiology; D055815:Young Adult