Enantioselective desymmetrizing palladium catalyzed carbonylation reactions: the catalytic asymmetric synthesis of quaternary carbon center containing 1,3-dienes.
A desymmetrization protocol has been used to develop a palladium catalyzed enantioselective carbonylation process. Achiral cyclic bis-alkenyltriflates are converted to their corresponding monoester derivatives with selectivities of up to 96% ee.
Byrne
Simon J
SJ
Department of Chemistry, University of Bath, Bath, UKBA2 7AY.
Fletcher
Anthony J
AJ
Hebeisen
Paul
P
Willis
Michael C
MC
D000498:Allyl Compounds / Q000138:chemical synthesis*; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D008956:Models, Chemical; D010165:Palladium / Q000737:chemistry*; D011090:Polyenes / Q000138:chemical synthesis*; D013237:Stereoisomerism
D000498:Allyl Compounds; D011090:Polyenes; D010165:Palladium; D002244:Carbon