[Expressions of Ep-CAM and cyclin D1 and their clinical significance in gallbladder carcinoma].
OBJECTIVE
To investigate the expressions of Ep-CAM and cyclin D1 and their correlation with the clinicopathological factors and prognosis in gallbladder carcinoma.


METHODS
Ep-CAM and cyclin D1 expressions were detected by PV6000 immunohistochemical staining in 60 gallbladder carcinoma and 15 para-cancerous mucosa specimens.


RESULTS
Ep-CAM and cyclin D1 expressions were detected in 56.7% and 48.3% of the cancer tissues, respectively, significantly higher than those in the normal mucosa (P < 0.05). Ep-CAM expression was not correlated with clinicopathological data, however cyclin D1 expression was correlated with pathological differentiation and necrosis (P < 0.05). Survival analysis showed that patients with positive Ep-CAM or cyclin D1 expression had a shorter survival time than that in the patients without (P < 0.05). Moreover, Ep-CAM and cyclin D1 expressions were positively correlated with each other (r = 0.307, P = 0.017).


CONCLUSIONS
Ep-CAM or cyclin D1 expression is a unfavorable prognostic factor in gallbladder carcinoma.
Department of Radiation Oncology, Chinese PLA General Hospital, Beijing 100853, China.
Gang
G
Ren
Guo
G
Yu
Li-wei
LW
Liu
Lin
L
Ma
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000368:Aged; D000951:Antigens, Neoplasm / Q000378:metabolism*; D018196:Carcinoma, Adenosquamous / Q000378:metabolism / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002454:Cell Differentiation; D019938:Cyclin D1 / Q000378:metabolism*; D000071858:Epithelial Cell Adhesion Molecule; D005260:Female; D005706:Gallbladder Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D015996:Survival Rate
D000951:Antigens, Neoplasm; C530104:CCND1 protein, human; D015815:Cell Adhesion Molecules; D000071858:Epithelial Cell Adhesion Molecule; D019938:Cyclin D1