Fixed dilated pupils and tacrolimus toxicity in paediatric liver transplant patients.
We report a case series of four children who developed fixed dilated pupils associated with high tacrolimus levels (>30 nanograms/millilitre [ng/mL]) in the immediate post-operative period following isolated liver or liver and small bowel transplantation.
Westrope
Claire
C
Paediatric Intensive Care Unit, Birmingham Children's Hospital NHS Foundation Trust, Birmingham, UK. claire@westropes.co.uk
Rowlands
Helen
H
Morris
Kevin
K
Gupte
Girish L
GL
D002648:Child; D003550:Cystic Fibrosis / Q000150:complications / Q000628:therapy; D004569:Electroencephalography / Q000379:methods; D005260:Female; D005403:Fixation, Ocular / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D007223:Infant; D017114:Liver Failure, Acute / Q000628:therapy; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D011680:Pupil / Q000187:drug effects*; D012778:Short Bowel Syndrome / Q000628:therapy; D016559:Tacrolimus / Q000009:adverse effects / Q000627:therapeutic use*
D007166:Immunosuppressive Agents; D016559:Tacrolimus