[Pregnancy: a high risk factor in influenza infection].
During pregnancy both mother and foetus are at increased risk of being infected with either pandemic or seasonal influenza viruses, and it is thus legitimate to implement enhanced surveillance for infection particularly with the A/H1N1v and discuss priority vaccine administration. We will review the alterations in immunologic parameters which lead to some degree of cellular immunodeficiency, but also in anatomic changes and pulmonary restrictions which contribute to this suceptibility of pregnant women to severe complications of an influenza infection. We also provide an update on the epidemiological data available for the A/H1N1v infection in this population, and discuss the benefit/risk ratio of treatment with the antiviral medications.
Université Paris Descartes, Service de maladies infectieuses et tropicales, Centre d'infectiologie Necker-Pasteur, Hôpital Necker-Enfants malades, Groupe infections de la mère et de l'enfant, Assistance publique-hôpitaux de Paris, 149, rue de Sèvres, 75015 Paris, France. caroline.charlier@nck.aphp.fr
Caroline
C
Charlier
Odile
O
Launay
Hélène
H
Coignard-Biehler
Marc
M
Lecuit
Olivier
O
Lortholary
D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000009:adverse effects / Q000627:therapeutic use; D004196:Disease Outbreaks; D004198:Disease Susceptibility; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005315:Fetal Diseases / Q000209:etiology; D006801:Humans; D007111:Immunity, Cellular; D016867:Immunocompromised Host; D007231:Infant, Newborn; D053118:Influenza A Virus, H1N1 Subtype; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000188:drug therapy / Q000453:epidemiology* / Q000209:etiology / Q000401:mortality / Q000517:prevention & control; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology* / Q000276:immunology / Q000401:mortality / Q000517:prevention & control; D055815:Young Adult
D000998:Antiviral Agents; D007252:Influenza Vaccines