[Peptic ulcer in patients with neurotic and affective disorders: comorbidity, clinicoendoscopic and psychopathological features, approaches to therapy].
OBJECTIVE
to study clinicoendoscopic and psychopathological relationships and the course of peptic ulcer (PU) in patients with neurotic and affective disorders and to evaluate the efficiency of psychopharmacotherapy, by applying a comprehensive approach to the treatment of comorbidies.


METHODS
The study covered 245 patients aged 43.3 +/- 8.8 years from the Department of Borderline Conditions who had been diagnosed as having duodenal PU and gastric PU with a prevalence of stress-associated neurotic disorders, as well as affective and other ones. Clinical psychopathological and experimental psychological tests and rating psychometric scales were used to evaluate the patients' mental status. Somatic diseases were verified by endoscopic, morphological, and ultrasound diagnostic techniques.


RESULTS
Multivariate analysis has revealed a relationship of the phase of an ulcerative process and age to the first manifestations of psychopathology, its duration, and gender. Assessment of psychopharmacotherapy in patients with PU has shown the high efficacy of the antidepressant of coaxil in the treatment of the comorbidity.


CONCLUSIONS
The polymorphism of psychopathological disorders and their trend are determined by the clinical changes in the course of an ulcerative or erosive process. The inclusion of coaxil into the combined treatment regimen for PU in patients with neurotic and affective disorders is expedient and pathogenetically founded at all stages of a follow-up.
Garganeeva
N P
NP
Kartashova
I G
IG
Semke
V Ia
VIa
D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D015897:Comorbidity; D004724:Endoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000150:complications / Q000188:drug therapy*; D009497:Neurotic Disorders / Q000150:complications / Q000188:drug therapy*; D010437:Peptic Ulcer / Q000188:drug therapy* / Q000473:pathology / Q000523:psychology*; D013841:Thiazepines / Q000627:therapeutic use*; D014463:Ultrasonography
D000928:Antidepressive Agents; D013841:Thiazepines; C050504:tianeptine