Corpus callosum segment circumference is associated with response control in children with attention-deficit hyperactivity disorder (ADHD).
Response control is impaired in attention-deficit hyperactivity disorder (ADHD). Given the corpus callosum's role in response control, we compared callosal morphology in 64 children with ADHD and 64 typically developing children, aged 7 to 13 years, and investigated the relationships between callosal morphology and response control. Area and circumference of 5 callosal segments (genu, rostral body, midbody, isthmus, and splenium) were normalized for cerebral volume and examined for correlation with mean reaction time, intrasubject variability, and/or commission error rate from a go/no-go task. There were no between-group differences in segment areas or circumferences. Reaction time correlated with midbody circumference for boys with ADHD and isthmus circumference for girls with ADHD. For the entire cohort, rostral body circumference correlated with intrasubject variability. Impaired response control in ADHD is associated with anomalies in frontal interhemispheric connections. Future studies examining callosal shape will illuminate the anatomic basis of correlations between callosal segment circumference and response control.
Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Melanie A
MA
McNally
Deana
D
Crocetti
E Mark
EM
Mahone
Martha B
MB
Denckla
Stacy J
SJ
Suskauer
Stewart H
SH
Mostofsky
D061085:Agenesis of Corpus Callosum; D016880:Anisotropy; D001289:Attention Deficit Disorder with Hyperactivity / Q000473:pathology* / Q000503:physiopathology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000503:physiopathology*; D002648:Child; D003337:Corpus Callosum / Q000503:physiopathology*; D056324:Diffusion Tensor Imaging; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009434:Neural Pathways / Q000002:abnormalities / Q000503:physiopathology; D009483:Neuropsychological Tests; D015588:Observer Variation; D011930:Reaction Time / Q000502:physiology; D012727:Sex Characteristics