Evaluation of the cytoprotective effects of bovine lactoferrin against intestinal toxins using cellular model systems.
Lactoferrin is an iron-binding glycoprotein that exhibits a range of health benefits including immune regulation and disease prevention derived from its structural properties. The present study employed immune cell models and a colon epithelial cell model to investigate the protective effects of bovine lactoferrin (BLf) on both immune cells and colon epithelium cells. BLf caused significant reduction of faecal genotoxin-induced DNA damage in HT29 cells, and down-regulation of lipopolysaccharide (LPS)-induced macrophage cell stress and endotoxic response, in an infection status.
Tian
Hong
H
School of Engineering and Advanced Technology, College of Sciences, Massey University, Auckland, New Zealand. sabrinatian@hotmail.com
Maddox
Ian S
IS
Ferguson
Lynnette R
LR
Shu
Quan
Q
D000818:Animals; D002417:Cattle; D002460:Cell Line; D003106:Colon / Q000737:chemistry* / Q000166:cytology / Q000473:pathology; D019610:Cytoprotection / Q000187:drug effects*; D004249:DNA Damage; D004847:Epithelial Cells / Q000187:drug effects* / Q000473:pathology; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D007781:Lactoferrin / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D008264:Macrophages / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D008954:Models, Biological; D009153:Mutagens / Q000494:pharmacology*; D013312:Stress, Physiological / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D008070:Lipopolysaccharides; D009153:Mutagens; D014409:Tumor Necrosis Factor-alpha; D007781:Lactoferrin