Urinary catecholamine and metadrenaline to creatinine ratios in dogs with a phaeochromocytoma.
Urinary adrenaline (epinephrine), noradrenaline, dopamine, metadrenaline (metanephrine) and normetadrenaline to creatinine ratios were measured from spot samples of seven client-owned dogs with a histologically confirmed phaeochromocytoma. Urine was collected on day 0 in the hospital in six dogs, and additionally on days 2, 6 and 7 after discharge in two of these dogs. In one dog, urine was sampled on day 7 only. Samples were also collected from 10 healthy control dogs on days 0, 1 and 7. In dogs with phaeochromocytomas, normetadrenaline:creatinine ratios at all time points ranged from 103 to 6430 nmol/mmol. From day 0, ratios of samples taken at the hospital (range 157 to 925 nmol/mmol) were significantly higher (P<0.0012) compared with control samples (range 14 to 91 nmol/mmol). The highest normetadrenaline:creatinine ratios were found in two dogs with bilateral phaeochromocytomas. Adrenaline:creatinine and noradrenaline:creatinine ratios were also significantly increased (P<0.016) in dogs with a phaeochromocytoma at day 0 compared with controls, although the difference was less pronounced than that between controls and dogs with a phaeochromocytoma for the normetadrenaline:creatinine ratio. Urine normetadrenaline:creatinine ratios may be useful in the diagnosis of canine phaeochromocytomas.
Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich, Winterthurerstrasse 260, 8057 Zurich, Switzerland. pkook@vetclinics.uzh.ch
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Kook
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Grest
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Quante
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Boretti
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Reusch
D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000662:veterinary*; D000818:Animals; D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D002395:Catecholamines / Q000652:urine*; D003404:Creatinine / Q000652:urine*; D004283:Dog Diseases / Q000175:diagnosis* / Q000652:urine; D004285:Dogs; D005260:Female; D008297:Male; D008676:Metanephrine / Q000652:urine*; D010673:Pheochromocytoma / Q000175:diagnosis / Q000662:veterinary*
D015415:Biomarkers; D002395:Catecholamines; D008676:Metanephrine; D003404:Creatinine