Transcriptional memory: staying in the loop.
Actively transcribed genes are organized into loops in which the 5' and 3' ends of the gene physically associate. Two new papers show that gene looping can persist after genes are repressed, promoting rapid reactivation of transcription, a phenomenon known as transcriptional memory.
Department of Biochemistry, Molecular Biology and Cell Biology, Hogan 2100, 2205 Tech Drive, Northwestern University, Evanston, IL 60201, USA. j-brickner@northwestern.edu
Jason H
JH
Brickner
D005690:Galactose / Q000378:metabolism; D005800:Genes, Fungal; D008957:Models, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D005690:Galactose