Synthesis and antiviral activity of an imidazo[1,2-a]pyrrolo[2,3-c]pyridine series against the bovine viral diarrhea virus.
A series of imidazo[1,2-a]pyrrolo[2,3-c]pyridines has been prepared and evaluated for their anti-BVDV activities in MDBK cells. From the synthesized analogues bearing modifications of the substituents at positions 2, 3, 7 and 8, compounds 10a, b, 16, 24, 25 and 26 exhibited significant anti-BVDV activities.
Clermont Université, University Clermont 1, EA 4231, Clermont-Ferrand F-63001, France. j-michel.chezal@u-clermont1.fr
Jean-Michel
JM
Chezal
Jan
J
Paeshuyse
Vincent
V
Gaumet
Damien
D
Canitrot
Aurélie
A
Maisonial
Claire
C
Lartigue
Alain
A
Gueiffier
Emmanuel
E
Moreau
Jean-Claude
JC
Teulade
Olivier
O
Chavignon
Johan
J
Neyts
D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001908:Diarrhea Viruses, Bovine Viral / Q000187:drug effects*; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D007093:Imidazoles; D011725:Pyridines; D011758:Pyrroles