Spatial memory deficits and thalamic serotonergic metabolite change in thiamine deficient rats.
The purposes of the present study were to verify the effects of a severe thiamine deficiency episode on spatial cognitive aspects and thalamic serotonergic parameters. The animals were submitted to a severe thiamine deficiency treatment that was interrupted after the onset of the last neurological signs. The results obtained confirm previous findings about TD deficiency effects on cognitive function and, further show that this vitamin increases the thalamic serotonine metabolite, 5-hidroxyindolacetic acid (5-HIAA), level. In addition, the present data shed light on the importance of this metabolite in spatial cognitive function.
Vigil
Fabio Antônio Borges
FA
Departamento de Bioquímica e Imunologia, Laboratório de Neurociência Comportamental e Molecular, LaNeC, Universidade Federal de Minas Gerais, Belo Horizonte 31270-010, Brazil.
Oliveira-Silva
Ieda de Fátima
Ide F
Ferreira
Lívia Freire
LF
Pereira
Silvia Rejane Castanheira
SR
Ribeiro
Angela Maria
AM
D000704:Analysis of Variance; D000818:Animals; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008569:Memory Disorders / Q000209:etiology / Q000378:metabolism*; D009483:Neuropsychological Tests; D011745:Pyrithiamine; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D013028:Space Perception / Q000502:physiology*; D013788:Thalamus / Q000378:metabolism*; D013832:Thiamine Deficiency / Q000139:chemically induced / Q000150:complications / Q000378:metabolism*; D013997:Time Factors
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D011745:Pyrithiamine