Nups take leave of the nuclear envelope to regulate transcription.
Although components of the nuclear pore complex have been implicated in gene regulation independent of their role at the nuclear envelope, the evidence so far has been indirect. Capelson et al. (2010) and Kalverda et al. (2010) now reveal that certain nucleoporins are actively involved in transcription inside the nucleoplasm of Drosophila cells.
Hou
Chunhui
C
Department of Biology, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA.
Corces
Victor G
VG
D000818:Animals; D004330:Drosophila / Q000378:metabolism*; D005786:Gene Expression Regulation; D009685:Nuclear Envelope / Q000378:metabolism; D028861:Nuclear Pore Complex Proteins / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
D028861:Nuclear Pore Complex Proteins