Short RNAs: how big is this iceberg?
Recent studies have reported the identification of piwi-associated RNAs (piRNAs) in Drosophila somatic cells. Interestingly, these piRNAs derive from the 3' untranslated regions of a subset of transcribed protein-coding genes and, experimentation suggests, might control the expression of other protein-coding transcripts. Studies of additional organisms support the new pathway's presence across animals.
Rigoutsos
Isidore
I
Bioinformatics and pattern Discovery Group, Computation Biology Center, IBM Thomas J. Watson Research Center, PO BOX 218, Yonktown Heights, NY 10598, USA. rigoutso@us.ibm.com <rigoutso@us.ibm.com>
D020413:3' Untranslated Regions; D000818:Animals; D002460:Cell Line; D004330:Drosophila / Q000235:genetics / Q000378:metabolism; D005260:Female; D008954:Models, Biological; D010053:Ovary / Q000166:cytology / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics* / Q000378:metabolism*
D020413:3' Untranslated Regions; D034741:RNA, Small Interfering