IDH1 mutations in gliomas: when an enzyme loses its grip.
The growing interest in cancer metabolism is best demonstrated by the rapid progress made in studying isocitrate dehydrogenase (IDH) mutations since their discovery just over a year ago. In a recent study published in Nature, Dang et al. identified 2-hydroxyglutarate as a product of tumor-associated IDH mutants with potential oncogenic activities.
Frezza
Christian
C
Cancer Research UK, The Beatson Institute for Cancer Research, Glasgow G61 1BD, UK.
Tennant
Daniel A
DA
Gottlieb
Eyal
E
D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics*; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism*; D005910:Glioma / Q000235:genetics*; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D009154:Mutation
D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human