[Antidiabetogenic action of Pro-Gly-Arg and Pro-Gly-Pro-Arg peptides after their intranasal chronic administration to animals].
It was shown that chronic (over 7 days) intranasal injection of the Pro-Gly-Arg tripeptide to rats in the dose 1 mg/kg before the injection of a diabetogenic dose of alloxan, promotes effective defense against development of insulin dependent diabetes mellitus. At the same time, the tetra-peptide Pro-Gly-Pro-Arg did not show a hypoglycemic affect during diabetes mellitus provocation. Administration of Pro-Gly-Arg and Pro-Gly-Pro-Arg peptides also activates anticoagulation potential.
Ul'ianov
A M
AM
Liapina
L A
LA
Obergan
T Iu
TIu
Shubina
T A
TA
Pastorova
V E
VE
Andreeva
L A
LA
Miasoedov
N F
NF
Ashmarin
I P
IP
D000281:Administration, Intranasal; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D007004:Hypoglycemic Agents; D009842:Oligopeptides