Biomimetic syntheses of the neurotrophic natural products caryolanemagnolol and clovanemagnolol.
Separate short and modular syntheses of the isomeric natural products caryolanemagnolol and clovanemagnolol have been achieved starting from commercially available (-)-caryophyllene. The postulated biosynthetic pathways guided the syntheses of the neuroregenerative small molecules allowing their assembly in as few as two steps.
Cheng
Xu
X
Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station, Austin Texas 78712, USA.
Harzdorf
Nicole L
NL
Shaw
Travis
T
Siegel
Dionicio
D
D001688:Biological Products / Q000096:biosynthesis / Q000138:chemical synthesis* / Q000737:chemistry; D032701:Biomimetics; D008968:Molecular Conformation; D009414:Nerve Growth Factors / Q000096:biosynthesis / Q000138:chemical synthesis* / Q000737:chemistry; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D001688:Biological Products; D009414:Nerve Growth Factors; D010636:Phenols; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C549995:caryolanemagnolol; C549996:clovanemagnolol; C024714:caryophyllene