Role of FGF19 induced FGFR4 activation in the regulation of glucose homeostasis.
FGF19, FGF21, and FGF23 form a unique subfamily of fibroblast growth factors. Because they contain intra-molecular disulfide bonds and show reduced affinity toward heparan sulfate located in the extracellular space, it is thought that, in contrast to other FGFs, they function as endocrine hormones. FGF23 and its co-receptor alphaKlotho are involved in the control of aging, but it is not known if the same holds true for FGF19, which can also signal through alphaKlotho. However, considerable evidence supports a role for FGF19 in controlling various aspects of metabolism. We have recently fully characterized FGF19/FGFR/co-factor interactions and signaling, and in the current manuscript discuss the contribution of the FGF19/FGFR4 axis to bile acid and glucose regulation.
Wu
Xinle
X
Amgen Inc., South San Francisco, CA 94080, USA. xinlew@amgen.com
Li
Yang
Y
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D051379:Mice; D051499:Receptor, Fibroblast Growth Factor, Type 4 / Q000378:metabolism*
D001647:Bile Acids and Salts; D001786:Blood Glucose; C117476:FGF19 protein, human; C000717427:FGF23 protein, human; C000717428:Fgf23 protein, mouse; C414620:fibroblast growth factor 21; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D051499:Receptor, Fibroblast Growth Factor, Type 4