Pan-azole-resistant Candida guilliermondii from a leukemia patient's silent funguria.
Isolation of Candida non-albicans yeasts as commensals or pathogens from hospitalised hosts is acquiring increasing importance, due to the frequent drug resistance expressed by such organisms.Particularly, the recover of antifungal resistant C. guilliermondii is of worrisome concern, even if recovered as a saprophyte, since commensal yeasts may behave as reservoirs for resistance elements;furthermore, they may enter the bloodstream after chemotherapy-related mucosal damage has developed,thus causing life-threatening and difficult-to-treat fungemias. This communication deals with the unusual isolation of a pan-azole resistant C. guilliermondii strain from a leukaemic patient with silent candiduria and emphasizes the importance of monitoring less recurring species within the nosocomial setting to better understand fungal epidemiology within the wards and face the spread of resistance determinants. Also, we highlight the controversial significance of silent candiduria, clinical relevance of which should be investigated case by case, to exclude and/or prevent candiduria as well as renal impairment.
Vincenzo
V
Savini
Chiara
C
Catavitello
Ilaria
I
Di Marzio
Gioviana
G
Masciarelli
Daniela
D
Astolfi
Andrea
A
Balbinot
Azaira
A
Bianco
Arianna
A
Pompilio
Giovanni
G
Di Bonaventura
Claudio
C
D'Amario
Domenico
D
D'Antonio
D000208:Acute Disease; D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000150:complications* / Q000382:microbiology; D025141:Drug Resistance, Fungal; D017809:Fatal Outcome; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008826:Microbial Sensitivity Tests; D014556:Urine / Q000382:microbiology*
D000935:Antifungal Agents; D001393:Azoles