A means to an end: ubiquitination of Mpl.
In this issue of Blood, Saur and colleagues report that ubiquitin-mediated degradation of the Mpl receptor constrains Tpo-mediated cell proliferation, highlighting the importance of the E3 ubiquitin ligase c-Cbl in rapid down-regulation of Tpo/Mpl signaling.
Tong
Wei
W
Children's Hospital of Philadelphia, PA, USA.