[Association between wnt signal pathway and post-infarction cardiac remodeling/rupture in aged mice].
OBJECTIVE
To observe the association between wnt signal pathway and post infarction left ventricular remodeling/rupture in mice with various ages.


METHODS
Three months-old (young group, n = 116) and 18 months-old (aged group, n = 116) male C57/BL mice were studied. Seventy mice underwent ligation of left coronary artery, 10 sham-operation and echocardiography and hemodynamics were performed 7 d post-infarction, 36 infarcted mice were used for detecting expression of dvl-1, beta-catenin and connexin 43 in left ventricular (LV) myocardium and infarction region at 3 d, 7 d, 14 d post infarction (n = 12 each).


RESULTS
Incidence of cardiac rupture was significantly higher in aged mice than in young mice (36.7% vs. 16.7%, P < 0.05) and degree of LV dilation and contractile dysfunction was significantly severer in aged mice than those in young mice post infarction. Expression of dvl-1, beta-catenin in left ventricle was upregulated in MI group compared with sham group (P < 0.05), expression of dvl-1 and beta-catenin in infarction region in MI 3d group in aged mice was significantly downregulated than in young mice (P < 0.05). Expression of connexin 43 is 2.15 fold higher in young sham mice than in aged sham mice (P < 0.05) and decreased significantly post infarction (P < 0.05). Expression of connexin 43 in infarction region in mice 3 d and 14 d post infarction was significantly lower in aged mice than in respective young mice (all P < 0.05).


CONCLUSIONS
Reductant activation of wnt signal pathway post infarction in aged mice might be responsible for increased incidence of cardiac rupture and aggravated remodeling.
Huang
Ying
Y
Cardiac Centre in First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Ma
Yi-Tong
YT
Yang
Yi-Ning
YN
Liu
Fen
F
Chen
Bang-Dang
BD
Li
Xiao-Mei
XM
D000375:Aging; D000818:Animals; D006341:Heart Rupture / Q000209:etiology*; D006352:Heart Ventricles; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology*; D009206:Myocardium / Q000378:metabolism*; D015398:Signal Transduction; D020257:Ventricular Remodeling; D051153:Wnt Proteins / Q000378:metabolism
D051153:Wnt Proteins