Incrementally applied multifaceted therapeutic bundles in neuroprotection clinical trials...time for change.
Kofke
W Andrew
WA
Department of Anesthesiology and Critical Care, University of Pennsylvania, 7 Dulles Building, 3400 Spruce St., Philadelphia, PA 19104-4283, USA. kofkea@uphs.upenn.edu
D000465:Algorithms; D001921:Brain / Q000503:physiopathology; D001925:Brain Damage, Chronic / Q000503:physiopathology / Q000517:prevention & control*; D001930:Brain Injuries / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003422:Critical Care / Q000379:methods*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D018696:Neuroprotective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D010348:Patient Care Team; D011787:Quality of Health Care; D012189:Retrospective Studies; D020521:Stroke / Q000188:drug therapy* / Q000503:physiopathology; D017211:Treatment Failure
D018696:Neuroprotective Agents