T lymphocyte apoptosis in asthma.
The paper describes the possible role of apoptosis of T lymphocytes in asthma pathogenesis. The authors focused on resistance against Fas-mediated programed cell death and the role of Bcl-2 protein in impaired programed cell death process. The reports from the literature regarding the imbalance of Th1 and Th2, caused by impaired apoptosis of T cells, in asthma pathogenesis are reviewed.
Department of Laboratory Diagnostics and Clinical Immunology of Developmental Age, Warsaw Medical University, Warsaw, Poland. olga.potapinska@wum.edu.pl
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Potapinska
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Demkow
D017209:Apoptosis; D001249:Asthma / Q000276:immunology*; D006801:Humans; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology*; D051028:bcl-2-Associated X Protein / Q000502:physiology; D019014:fas Receptor / Q000502:physiology
D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; D019014:fas Receptor