Palladium-catalyzed intermolecular aminofluorination of styrenes.
A novel palladium-catalyzed intermolecular aminofluorination of styrenes, with N-fluorobenzenesulfonimide (NFSI) functioning not only as a fluorinating reagent but also as an aminating reagent, has been developed. The reaction afforded vicinal fluoroamine products with very high regioselectivity. This transformation may involve fluoropalladation of styrene as a key step for C-F bond formation. The bidental nitrogen ligand is crucial to achieving the transformation successfully.
Qiu
Shuifa
S
State Key Laboratory of Organometallics Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai, China, 200032.
Xu
Tao
T
Zhou
Juan
J
Guo
Yinlong
Y
Liu
Guosheng
G
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013343:Styrenes / Q000737:chemistry*
D000588:Amines; D009942:Organometallic Compounds; D013343:Styrenes; D010165:Palladium