Chromatin modifiers, cognitive disorders, and imprinted genes.
In this issue of Developmental Cell, Kernohan et al. link the chromatin regulatory proteins ATRX, MeCP2, CTCF, and cohesin with silencing of H19 and other imprinted genes during critical stages of postnatal brain development, perhaps suggesting a common etiology for several human diseases that exhibit defects in brain development and function.
Cunningham
Melissa D
MD
Program in Genomics of Differentiation, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA.
Kassis
Judith A
JA
Pfeifer
Karl
K
D000818:Animals; D001921:Brain / Q000254:growth & development / Q000378:metabolism; D000076246:CCCTC-Binding Factor; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism; D003072:Cognition Disorders / Q000235:genetics*; D004265:DNA Helicases / Q000235:genetics / Q000378:metabolism; D005260:Female; D020868:Gene Silencing; D018392:Genomic Imprinting; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics / Q000378:metabolism; D008297:Male; D051783:Methyl-CpG-Binding Protein 2 / Q000235:genetics / Q000378:metabolism; D051379:Mice; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000235:genetics; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D000075924:X-linked Nuclear Protein; D000097722:Cohesins
D000076246:CCCTC-Binding Factor; D018797:Cell Cycle Proteins; D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D004265:DNA Helicases; D007335:Insulin-Like Growth Factor II; D051783:Methyl-CpG-Binding Protein 2; D009687:Nuclear Proteins; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated; D012097:Repressor Proteins; D000075924:X-linked Nuclear Protein; D000097722:Cohesins; C000619697:CTCF protein, human; C000619698:Ctcf protein, mouse; C094335:H19 long non-coding RNA; C513121:IGF2 protein, mouse; C497393:Mecp2 protein, mouse; C490462:Atrx protein, mouse