QuantiFERON-TB Gold In-Tube test (QFT-GIT) for the screening of latent tuberculosis in recent immigrants to Italy.
To evaluate the agreement between QuantiFERON-TB Gold In-Tube test (QFT-GIT) and tuberculin skin test (TST) for the screening of latent tuberculosis infection (LTBI) in recent immigrants to Italy, 279 subjects were submitted to concomitant TST and QFT-GIT. The agreement was analyzed using k statistics. A total of 72/279 (25.8%) individuals were TST positive, while 107/279 (38.3%) were QFT-GIT positive. The overall agreement between QFT-GIT and TST was 70.9%, with k statistic of 0.35. Using different TST and QFT-GIT cut-offs, the best concordance value was obtained for QFT-GIT at > 2.64 IU/ml and TST at > 10mm (k = 0.409). Discordant results were found for 58 subjects (21%) with QFT-GIT positive/TST negative and 23 (8%) with QFT-GIT negative/TST positive. A high amount of discordance QFT-GIT+/TST- was described. QFT-GIT might increase the identification of LTBI cases among recent immigrants.
Saracino
Annalisa
A
Clinic of Infectious Diseases, University of Foggia, Italy. a.saracino@medicina.unifg.it
Scotto
Gaetano
G
Fornabaio
Chiara
C
Martinelli
Domenico
D
Faleo
Giuseppina
G
Cibelli
Donatella
D
Tartaglia
Alessandra
A
Di Tullio
Rocco
R
Fazio
Vincenzina
V
Prato
Rosa
R
Monno
Laura
L
Angarano
Gioacchino
G
D000328:Adult; D054242:Emigrants and Immigrants; D005260:Female; D006801:Humans; D007371:Interferon-gamma / Q000097:blood*; D007558:Italy; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D008403:Mass Screening / Q000379:methods*; D009169:Mycobacterium tuberculosis / Q000276:immunology; D011933:Reagent Kits, Diagnostic; D012882:Skin Tests; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000453:epidemiology; D055815:Young Adult
D011933:Reagent Kits, Diagnostic; D007371:Interferon-gamma