Biodistribution of (137)Cs in a mouse model of chronic contamination by ingestion and effects on the hematopoietic system.
The aim of this work was to define the possible occurrence of hematological changes during the course of a chronic ingestion of (137)Cs. A mouse model was used, with ingestion through drinking water with a cesium concentration of 20 kBq l(-1). Ingestion started in parent animals before mating, and (137)Cs intake and its effect on the hematopoietic system was studied in offspring at various ages between birth and 20 weeks. (137)Cs content was measured in various organs, indicating that (137)Cs was distributed throughout the organism including lympho-hematopoietic organs, i.e., femurs, spleen and thymus. However, we did not observe any effect on the hematopoietic system, whatever the parameter used. In fact, blood cell counts, mononuclear cell counts and progenitor frequency in bone marrow and spleen, and Flt3-ligand, Erythropoietin, G-CSF and SDF-1 concentration in plasma remained unchanged when compared to control animals. Moreover, phenotypic analysis did not show any change in the proportions of bone marrow cell populations. These results indicate that, although (137)Cs was found in all organs implicated in the hematopoietic system, this did not induce any changes in bone marrow function.
Bertho
Jean-Marc
JM
Laboratoire de radiotoxicologie expérimentale DRPH/SRBE, LRTOX, IRSN, BP no. 17, 92262, Fontenay aux roses Cedex, France. jean-marc.bertho@irsn.fr
Louiba
Sonia
S
Faure
Marie-Cécile
MC
Tourlonias
Elie
E
Stefani
Johanna
J
Siffert
Baptiste
B
Paquet
François
F
Dublineau
Isabelle
I
D000367:Age Factors; D000818:Animals; D001772:Blood Cell Count; D002588:Cesium Radioisotopes / Q000009:adverse effects* / Q000493:pharmacokinetics*; D016207:Cytokines / Q000097:blood; D004326:Drinking; D004435:Eating; D005260:Female; D005333:Fetus; D006413:Hematopoietic System / Q000166:cytology / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D023421:Models, Animal; D010641:Phenotype; D012098:Reproduction / Q000528:radiation effects; D013997:Time Factors
D002588:Cesium Radioisotopes; D016207:Cytokines