Stromal compartment as a survival prognostic factor in advanced ovarian carcinoma.
OBJECTIVE
We investigated the prognostic significance of stromal compartment on the overall survival of patients with advanced epithelial ovarian cancer.


METHODS
We evaluated retrospectively the stroma proportion of the tumor surgical specimens of 194 patients with stages III and IV disease, using histochemical staining and fully automatic virtual slide processing. The prognostic significance of stroma proportion and clinical parameters were evaluated using log-rank test and Cox regression.


RESULTS
Stroma proportion was found to be an independent prognostic factor by both univariate (P = 0.016) and multivariate analyses (hazards ratio = 1.45, P = 0.011).


CONCLUSIONS
The present data indicate that a high stroma proportion is related to a poor prognosis of stage III and IV ovarian carcinomas.
Groupe Régional d'Etudes sur le Cancer, Centre Fran0ois Baclesse, 3 Ave Général Harris, Cedex 05, 14076 Caen, France. a.labiche@baclesse.fr
Alexandre
A
Labiche
Natacha
N
Heutte
Paulette
P
Herlin
Jacques
J
Chasle
Pascal
P
Gauduchon
Nicolas
N
Elie
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000175:diagnosis* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D018450:Disease Progression; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D017154:Stromal Cells / Q000473:pathology*; D016019:Survival Analysis; D013997:Time Factors
D014408:Biomarkers, Tumor