Retinal vasculitis associated with the anti-synthetase syndrome.
A 50-year-old woman with a history of anti-Jo1-positive inflammatory myositis and interstitial lung disease presented with decreased vision in her right eye. Examination revealed white-centered hemorrhages scattered across the posterior pole in addition to several areas of vascular sheathing. Treatment was initiated with intravenous pulse solumedrol, with improvement in vision and resolution of the patient's white-centered hemorrhages. A thorough workup for other causes of vasculitis was unrevealing. Anti-synthetase syndrome is a serologically defined disorder clinically characterized by inflammatory myositis, interstitial lung disease, and other systemic findings. To our knowledge, retinal vasculitis has not been previously reported in patients with anti-synthetase syndrome.
Cole Eye Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA.
Ahmad B
AB
Tarabishy
Mariam
M
Khan
Matthew
M
Bunyard
Careen Y
CY
Lowder
D000974:Antibodies, Antinuclear / Q000097:blood; D005260:Female; D006643:Histidine-tRNA Ligase / Q000276:immunology; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008776:Methylprednisolone Hemisuccinate / Q000627:therapeutic use*; D008875:Middle Aged; D009220:Myositis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D031300:Retinal Vasculitis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D013577:Syndrome; D014792:Visual Acuity
D000974:Antibodies, Antinuclear; C046750:Jo-1 antibody; D008776:Methylprednisolone Hemisuccinate; D006643:Histidine-tRNA Ligase