Iatrogenic botulism after botulinum toxin type A injections.
Therapeutic use of botulinum toxin type A (BT/A) is well known, effective, and safe. Iatrogenic botulism that presents with generalized weakness, dysphagia, and respiratory distress is a rare but significant complication in BT/A treatment. In this study, we report 4 patients who developed iatrogenic botulism after receiving therapeutic doses of BT/A for spasticity and blepharospasm. One patient was placed in intensive care unit, but consequently, every patient recovered fully. The cause of BT/A as an adverse effect is most likely hematological spread of the toxin.
Coban
Arzu
A
Department of Neurology, Balikesir University Medical Faculty, Cağiş, Balikesir, Turkey.
Matur
Zeliha
Z
Hanagasi
Hasmet A
HA
Parman
Yesim
Y
D000328:Adult; D000368:Aged; D018726:Anti-Dyskinesia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001764:Blepharospasm / Q000188:drug therapy; D019274:Botulinum Toxins, Type A / Q000009:adverse effects* / Q000627:therapeutic use; D001906:Botulism / Q000209:etiology*; D016903:Drug Monitoring; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease; D009128:Muscle Spasticity / Q000188:drug therapy; D013997:Time Factors; D016896:Treatment Outcome
D018726:Anti-Dyskinesia Agents; D019274:Botulinum Toxins, Type A