Safety, immunogenicity and immediate pain of intramuscular versus subcutaneous administration of a measles-mumps-rubella-varicella vaccine to children aged 11-21 months.
This study compared intramuscular and subcutaneous administration of two doses of measles-mumps-rubella-varicella (MMRV) combination vaccine (Priorix-Tetra, GlaxoSmithKline Biologicals) in children. Healthy children (N = 328) were randomised to receive MMRV either intramuscularly or subcutaneously. Reactogenicity was similar between treatment groups for immediate vaccination pain, vaccination site pain, redness and incidence of fever and rashes. Slightly less vaccination site swelling occurred during days 0-3 of the post-vaccination period after intramuscular administration. Seroconversion rates for all components, 42-56 days post-dose 2, ranged from 99.3% to 100% in the intramuscular group and from 98.6% to 100% in the subcutaneous. Cell-mediated immunity data supported the humoral immunogenicity findings. In summary, the MMRV vaccine is well tolerated and highly immunogenic when administered either subcutaneously or intramuscularly to children in the second year of life.
Knuf
Markus
M
Children's Hospital, Dr. Horst Schmidt Klinik, Ludwig-Erhard-Str. 100, Wiesbaden 65199, Germany. Markus.Knuf@hsk-wiesbaden.de
Zepp
Fred
F
Meyer
Claudius U
CU
Habermehl
Pirmin
P
Maurer
Lothar
L
Burow
Hanns-Michael
HM
Behre
Ulrich
U
Janssens
Michel
M
Willems
Paul
P
Bisanz
Helmtrud
H
Vetter
Volker
V
Schmidt-Ott
Ruprecht
R
D000914:Antibodies, Viral / Q000097:blood*; D000917:Antibody Formation / Q000276:immunology; D019433:Chickenpox Vaccine / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology*; D005076:Exanthema / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D005334:Fever / Q000139:chemically induced* / Q000453:epidemiology; D005455:Fluorescent Antibody Technique; D006801:Humans; D056724:Immunity, Humoral / Q000276:immunology; D007223:Infant; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D008297:Male; D022542:Measles-Mumps-Rubella Vaccine / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology*; D010146:Pain / Q000139:chemically induced* / Q000453:epidemiology; D017778:Vaccines, Combined
D000914:Antibodies, Viral; D019433:Chickenpox Vaccine; D022542:Measles-Mumps-Rubella Vaccine; D017778:Vaccines, Combined; C050102:measles, mumps, rubella, varicella vaccine