Leech-derived thrombin inhibitors: from structures to mechanisms to clinical applications.
Corral-Rodríguez
María Angeles
MA
Institut de Recerca, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Macedo-Ribeiro
Sandra
S
Pereira
Pedro José Barbosa
PJ
Fuentes-Prior
Pablo
P
D000595:Amino Acid Sequence; D000818:Animals; D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006629:Hirudins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007447:Invertebrate Hormones / Q000737:chemistry / Q000494:pharmacology; D007865:Leeches / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011506:Proteins / Q000737:chemistry / Q000494:pharmacology; D013917:Thrombin / Q000037:antagonists & inhibitors*
D065427:Factor Xa Inhibitors; D005343:Fibrinolytic Agents; D006629:Hirudins; D007447:Invertebrate Hormones; D011506:Proteins; C080680:haemadin; C415823:therostasin protein, Theromyzon tessulatum; C053155:antistasin; D013917:Thrombin