Vitamin E and cancer.
Protection by vitamin E against free radical-induced DNA mutations appears not to be an effective occurrence. On the other hand, in vitro evidence that different tocopherols slow down cell proliferation is an accepted observation. However, such an event may not be sufficient to result in beneficial clinical outcomes. Tocopheryl phosphate, a more active, natural derivative of tocopherol, endowed with prevention and therapeutic potential, represents a possible key to the understanding of the present conflict between laboratory and clinical results.
Tufts University, Boston, Massachusetts 02111, USA.
Yesim
Y
Negis
Jean Marc
JM
Zingg
Roksan
R
Libinaki
Mohsen
M
Meydani
Angelo
A
Azzi
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects; D018450:Disease Progression; D016166:Free Radical Scavengers / Q000494:pharmacology / Q000627:therapeutic use; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D016296:Mutagenesis / Q000187:drug effects; D009369:Neoplasms / Q000188:drug therapy / Q000517:prevention & control*; D009928:Organ Specificity; D051381:Rats; D014810:Vitamin E / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use
D016588:Anticarcinogenic Agents; D000972:Antineoplastic Agents, Phytogenic; D016166:Free Radical Scavengers; D014810:Vitamin E; C012552:alpha-tocopherol phosphate; D024502:alpha-Tocopherol