The effect of hydrocortisone on neurodevelopmental outcome in premature infants less than 29 weeks' gestation.
The use of postnatal dexamethasone in premature newborns can be associated with a deleterious neurodevelopmental outcome. The effect of hydrocortisone on developmental outcome in these patients is less clear. We therefore sought to examine the effect of hydrocortisone on early developmental outcome in premature newborns. We retrospectively examined the effect of hydrocortisone on developmental outcome during the first 2 years of life in premature infants <29 weeks' gestation at birth. Even though hydrocortisone was used in infants with a greater risk for poor outcome, its use, unless prolonged >7 days, was generally not associated with a worse developmental outcome or higher rate of referral for early intervention. A short course of hydrocortisone in sick premature newborns does not appear to have a deleterious effect on developmental outcome.
Department of Pediatrics, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA. hneedelm@unmc.edu
Howard
H
Needelman
Arvind
A
Hoskoppal
Arvind
A
Hoskappal
Holly
H
Roberts
Martha
M
Evans
J B
JB
Bodensteiner
D000367:Age Factors; D000893:Anti-Inflammatory Agents / Q000009:adverse effects; D001921:Brain / Q000187:drug effects / Q000254:growth & development / Q000503:physiopathology; D003072:Cognition Disorders / Q000139:chemically induced / Q000503:physiopathology; D002658:Developmental Disabilities / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects*; D007022:Hypotension / Q000188:drug therapy; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data*; D008171:Lung Diseases / Q000188:drug therapy; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D006854:Hydrocortisone