Short RNAs: how big is this iceberg?
Recent studies have reported the identification of piwi-associated RNAs (piRNAs) in Drosophila somatic cells. Interestingly, these piRNAs derive from the 3' untranslated regions of a subset of transcribed protein-coding genes and, experimentation suggests, might control the expression of other protein-coding transcripts. Studies of additional organisms support the new pathway's presence across animals.
Bioinformatics and pattern Discovery Group, Computation Biology Center, IBM Thomas J. Watson Research Center, PO BOX 218, Yonktown Heights, NY 10598, USA. rigoutso@us.ibm.com <rigoutso@us.ibm.com>
Isidore
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Rigoutsos
D020413:3' Untranslated Regions; D000818:Animals; D002460:Cell Line; D004330:Drosophila / Q000235:genetics / Q000378:metabolism; D005260:Female; D008954:Models, Biological; D010053:Ovary / Q000166:cytology / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics* / Q000378:metabolism*
D020413:3' Untranslated Regions; D034741:RNA, Small Interfering