Drug interactions of clinical importance among the opioids, methadone and buprenorphine, and other frequently prescribed medications: a review.
Drug interactions are a leading cause of morbidity and mortality. Methadone and buprenorphine are frequently prescribed for the treatment of opioid addiction. Patients needing treatment with these medications often have co-occurring medical and mental illnesses that require medication treatment. The abuse of illicit substances is also common in opioid-addicted individuals. These clinical realities place patients being treated with methadone and buprenorphine at risk for potentially toxic drug interactions. A substantial literature has accumulated on drug interactions between either methadone or buprenorphine with other medications when ingested concomitantly by humans. This review summarizes current literature in this area.
McCance-Katz
Elinore F
EF
Department of Psychiatry, University of California, San Francisco, San Francisco, California, USA. elinore.mccance-katz@ucsf.edu
Sullivan
Lynn E
LE
Nallani
Srikanth
S
D002047:Buprenorphine / Q000009:adverse effects* / Q000493:pharmacokinetics; D065690:Cytochrome P-450 CYP2D6 Inhibitors; D004347:Drug Interactions; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects; D008691:Methadone / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000494:pharmacology; D009293:Opioid-Related Disorders / Q000188:drug therapy; D055553:Prescription Drugs / Q000009:adverse effects; D019966:Substance-Related Disorders / Q000150:complications / Q000188:drug therapy
D065690:Cytochrome P-450 CYP2D6 Inhibitors; D013287:Illicit Drugs; D055553:Prescription Drugs; D002047:Buprenorphine; D008691:Methadone