Clinical efficacy of acupuncture on the morphine-related side effects in patients undergoing spinal-epidural anesthesia and analgesia.
OBJECTIVE
To investigate the effects of acupuncture on the morphine-related side effects (nausea, vomiting, itchiness and gastrointestinal disorders) in patients undergoing anesthesia and analgesia and try to find the clinical mechanism of acupuncture.


METHODS
Patients scheduled to have transurethral prostatic resection: enrolled in the study (69 patients), characterized as Grade II or III by the American Society of Anesthesiologists physical status classification, were randomly assigned to three groups, 23 patients in each group: the placebo group (control group), non-anesthesia area (NAA) group, and the anesthesia area (AA) group. After spinal anesthesia, all patients received Patients Controlled Epidural Analgesia. The vital signs, bowel sounds, visual analogue scales, itchiness, nausea and vomiting, and time for first exhaust post operation were observed.


RESULTS
Altogether, nine cases were eliminated, three in each group. Finally, sixty cases completed this study,: twenty in each group. There was a significant decrease of bowel sounds after morphine spinal anesthesia in the three groups. Compared with the control or AA group, the bowel sound recovered after acupuncture, the incidences of nausea and vomiting, itchiness, and time for first exhaust after operation decreased in the NAA group (P<0.05). There was a significant decrease of the incidence for itchiness in the NAA group compared with <the control group (P<0.05).


CONCLUSIONS
On the basis of this study, it is obviously seen that acupuncture could: decrease the incidence of morphine-related side effects (nausea and vomiting, itchiness and gastrointestinal disorders) when the spinal cord conduct is normal. However, it decreases only the incidence of itchiness but not for gastrointestinal dysfunction when the spinal cord is blocked.
Jiang
Yi-Hong
YH
Department of Anesthesiology, Hospital Affiliated to Guilin Medical College, Guangxi Zhuang Autonomous Region 541001, China. jiangyihong@163.com
Jiang
Wei
W
Jiang
Lei-Ming
LM
Lin
Gao-Xiang
GX
Yang
Hua
H
Tan
Yi
Y
Xiong
Wei-Wei
WW
D015670:Acupuncture Therapy; D000368:Aged; D000369:Aged, 80 and over; D000698:Analgesia / Q000009:adverse effects*; D015360:Analgesia, Epidural / Q000009:adverse effects; D000767:Anesthesia, Epidural / Q000009:adverse effects* / Q000379:methods; D000775:Anesthesia, Spinal / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D007422:Intestines / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects*; D011183:Postoperative Complications / Q000517:prevention & control; D020250:Postoperative Nausea and Vomiting / Q000517:prevention & control / Q000628:therapy; D011470:Prostatic Hyperplasia / Q000503:physiopathology / Q000601:surgery; D011537:Pruritus / Q000628:therapy; D020728:Transurethral Resection of Prostate / Q000534:rehabilitation; D016896:Treatment Outcome
D009020:Morphine