Innate antiviral immunity in Drosophila.
The study of Drosophila, and other genetically tractable insects, has expanded our understanding of innate immunity and more recently antiviral innate mechanisms. The Drosophila antiviral program includes inflammatory signaling cascades as well as antiviral RNA silencing and autophagy. This review will highlight the recent discoveries in antiviral immunity in insects and will reveal some of the lessons learned.
Sabin
Leah R
LR
Department of Microbiology, The University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Hanna
Sheri L
SL
Cherry
Sara
S
D000818:Animals; D001343:Autophagy; D004331:Drosophila melanogaster / Q000235:genetics / Q000276:immunology* / Q000378:metabolism / Q000821:virology*; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D034622:RNA Interference; D015398:Signal Transduction