Dual-acting beta2 agonists/muscarinic antagonists.
Bifunctional aromatic derivatives that act as both beta(2) agonists and muscarinic receptor antagonists are claimed. The compounds use two separate pharmacophoric groups, coupled by a long lipohilic chain, to provide the desired biological activities and with the aim of providing a long duration of action. The compounds are claimed to be useful in the treatment of both asthma and chronic obstructive pulmonary disease and represent the first disclosure of a new concept - muscarinic antagonist-beta(2) agonists.
Norman
Peter
P
Norman Consulting, 18 Pink Lane, Burnham, Buckinghamshire, SL1 8JW, UK.