[Herpes simplex virus bronchopneumonitis in patient with acute respiratory failure after surgery].
Herpes simplex virus bronchopneumonitis is a clinical entity described in critically ill patients and classically associated to immunosuppression. Recent reports have shown a higher frequency of virus detection from samples obtained by bronchoalveolar lavage of immunocompetent critically ill patients undergoing mechanical ventilation. This fact suggests its role as an independent pathogenic substrate. We report the case of a female patient who was admitted after an elective surgery of rectal tumor with suspected bronchoaspiration during anesthetic induction. The patient presented persistent fever despite broad spectrum antibiotic treatment. All cultures were negative for bacterial growth. The chest X-ray did not show opacifities. Prolonged mechanical ventilation with repeated failures to wean made it mandatory to perform percutaneous tracheostomy. A fibrobronchoscopy with bronchoalveolar lavage, performed previously, showed positive result for herpes simplex virus (PCR and specific nuclear inclusions in cells). Thus, treatment was initiated with acyclovir, with clinical improvement and weaning from mechanical ventilation.
Servicio de Medicina Intensiva, Hospital Virgen del Camino, Pamplona, Navarra, España. manolillou@yahoo.es
M
M
García-Montesinos-De la Peña
L
L
Oteiza-López
S
S
Aldunate-Calvo
M J
MJ
Gómez-Sánchez
J J
JJ
Sáenz-Bañuelos
J A
JA
Tihista-Jiménez
D000208:Acute Disease; D000212:Acyclovir / Q000627:therapeutic use; D000230:Adenocarcinoma / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid / Q000821:virology; D001996:Bronchopneumonia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use; D006561:Herpes Simplex / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D016867:Immunocompromised Host; D011015:Pneumonia, Aspiration / Q000175:diagnosis; D011024:Pneumonia, Viral / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology* / Q000628:therapy / Q000821:virology; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000601:surgery; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000628:therapy
D000964:Antimetabolites, Antineoplastic; D000998:Antiviral Agents; D005472:Fluorouracil; D000212:Acyclovir