Transient hepatitis B surface antigen circulation after Infanrix-Hexa: a case report and review of the literature.
The authors describe the case of a 70-day-old boy who was mistakenly diagnosed as suffering from acute hepatitis B, when he presented with persistent unconjugated hyperbilirubinemia and transaminasemia and was found to be seropositive for the hepatitis B surface antigen. The antigenemia was transient and related to his recent immunization with Infanrix-Hexa. Caution is required during interpretation of a positive HBsAg test that is obtained within 28 days after vaccination against hepatitis B.
Department of Pediatrics, University General Hospital of Alexandroupolis, Democritus University of Thrace, Medical School, Alexandroupolis, Greece, emantada@med.duth.gr.
Elpis
E
Mantadakis
Stavros
S
Thomaidis
Eugnosia-Nektaria
EN
Efraimidou
Anna
A
Ramatani
Athanassios
A
Chatzimichael
D000208:Acute Disease; D003937:Diagnosis, Differential; D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines / Q000008:administration & dosage* / Q000009:adverse effects*; D018073:Haemophilus Vaccines / Q000008:administration & dosage* / Q000009:adverse effects*; D006509:Hepatitis B / Q000097:blood / Q000175:diagnosis; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006801:Humans; D006932:Hyperbilirubinemia / Q000276:immunology; D007223:Infant; D008297:Male; D011054:Poliovirus Vaccine, Inactivated / Q000008:administration & dosage* / Q000009:adverse effects*; D013997:Time Factors; D000637:Transaminases / Q000097:blood; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000009:adverse effects
D022681:Diphtheria-Tetanus-acellular Pertussis Vaccines; D018073:Haemophilus Vaccines; D006514:Hepatitis B Surface Antigens; D011054:Poliovirus Vaccine, Inactivated; D017778:Vaccines, Combined; D000637:Transaminases