The incidence, characteristics, and presentation of dengue virus infections during infancy.
Infants are a vulnerable and unique population at risk for dengue in endemic areas. This report describes the incidence and presenting clinical features of infant dengue virus (DENV) infections from a prospective community-based study performed between January 2007 and May 2009 in the Philippines. DENV3 was the predominant infecting serotype over a wide spectrum of disease severity, ranging from inapparent infection to dengue hemorrhagic fever (DHF). In 2007, the incidence of inapparent DENV infections during infancy was 103 per 1,000 persons person-years and 6-fold higher than symptomatic dengue. The age-specific incidence of infant DHF was 0.5 per 1,000 persons over the age of 3-8 months, and it disappeared by age 9 months. A febrile seizure, macular rash, petechiae, and lower platelet count were presenting clinical features associated with DENV infection among infants with acute undifferentiated febrile illnesses. Community-based studies can help to delineate the incidence rates, disease spectrum, and clinical features of DENV infections during infancy.
Capeding
Rosario Z
RZ
Departments of Microbiology and Medicine, Research Institute for Tropical Medicine, Manila, Philippines.
Brion
Job D
JD
Caponpon
Mercydina M
MM
Gibbons
Robert V
RV
Jarman
Richard G
RG
Yoon
In-Kyu
IK
Libraty
Daniel H
DH
D017677:Age Distribution; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology; D003715:Dengue / Q000175:diagnosis* / Q000453:epidemiology*; D003716:Dengue Virus / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood / Q000276:immunology; D015994:Incidence; D007223:Infant; D008297:Male; D010679:Philippines / Q000453:epidemiology
D000914:Antibodies, Viral; D007075:Immunoglobulin M