Borna disease in an adult alpaca stallion (Lama pacos).
Borna disease (BD) was diagnosed in a 2-year-old male alpaca with a history of chronic suppressed sexual desire and acute stretching convulsions. Microscopical examination of the central nervous system revealed non-purulent meningoencephalitis with mononuclear perivascular cuffing. The diagnosis was confirmed by immunohistochemistry, in-situ hybridization, polymerase chain reaction (PCR) and sequencing of PCR products and alignment with known Borna disease virus sequences. Serological screening of the herd was performed. This is the first detailed report of naturally occurring BD in alpacas.
Department of Pathology, University of Veterinary Medicine Hannover, Hannover, Germany. bjoern.jacobsen@tiho-hannover.de
B
B
Jacobsen
D
D
Algermissen
D
D
Schaudien
M
M
Venner
S
S
Herzog
E
E
Wentz
M
M
Hewicker-Trautwein
W
W
Baumgärtner
C
C
Herden
D000818:Animals; D001890:Borna Disease / Q000175:diagnosis* / Q000473:pathology; D001891:Borna disease virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D001921:Brain / Q000473:pathology / Q000821:virology; D002161:Camelids, New World / Q000821:virology*; D017809:Fatal Outcome; D005858:Germany; D008297:Male; D008590:Meningoencephalitis / Q000473:pathology; D012367:RNA, Viral / Q000235:genetics; D017423:Sequence Analysis, RNA
D012367:RNA, Viral