Synthesis and biological evaluation of heteroanalogues of kotalanol and de-O-sulfonated kotalanol.
The synthesis of nitrogen and selenium analogues of kotalanol and de-O-sulfonated kotalanol, naturally occurring sulfonium-ion glucosidase inhibitors isolated from Salacia reticulata, and their evaluation as glucosidase inhibitors against the N-terminal catalytic domain of human maltase glucoamylase (ntMGAM) are described.
Department of Chemistry, Simon Fraser University, Burnaby, British Columbia, Canada V5A 1S6.
Sankar
S
Mohan
Kumarasamy
K
Jayakanthan
Ravindranath
R
Nasi
Douglas A
DA
Kuntz
David R
DR
Rose
B Mario
BM
Pinto
D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D007422:Intestines / Q000201:enzymology; D009005:Monosaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013431:Sulfates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013451:Sulfonic Acids / Q000737:chemistry*
D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; C114502:Kotalanol; D009005:Monosaccharides; D013431:Sulfates; D013451:Sulfonic Acids