[PSA and spironolactone].
The spironolactone is a diuretic of potassium savings. It is also used in the treatment of the hirsutism for its antiandrogenic action. Its use and its effects on the patients affected by a prostate cancer are less known. We report the case of a 72-year-old man having a cancer of prostate which normalized its PSA after institution of a treatment by spironolactone for ascites. This patient had a biological recurrence of a prostate cancer, arisen 7 years later after a treatment by hormonal radiotherapy. Nine months after the implementation of the treatment by spironolactone, there were no clinical and biological signs of disease progress.
Rybikowski
S
S
Service d'urologie, hôpital de la Conception, 147, boulevard Baille, 13005 Marseille, France. stanryb@free.fr
Maurin
C
C
Deturmeny
J
J
Delaporte
V
V
Lechevallier
E
E
Coulange
C
C
D000368:Aged; D000726:Androgen Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology / Q000532:radiotherapy*; D013148:Spironolactone / Q000627:therapeutic use*
D000726:Androgen Antagonists; D013148:Spironolactone; D017430:Prostate-Specific Antigen