A new dress code for MMPs: cleavage optional.
Matrix metalloproteinases are well known for their key roles in the processing of extracellular matrix and nonmatrix molecules. Recently, a new theme of proteolysis-independent roles for metalloproteinases has emerged, with a paper from Gonzalo et al. in this issue of Developmental Cell providing an illustration.
Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA.
Barbara
B
Fingleton
Conor C
CC
Lynch
D000818:Animals; D016723:Bone Remodeling / Q000502:physiology; D020134:Catalytic Domain / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D002459:Cell Fusion; D002465:Cell Movement / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism*; D022423:Myeloid Cells / Q000201:enzymology*; D010010:Osteoclasts / Q000201:enzymology*; D010447:Peptide Hydrolases / Q000235:genetics / Q000378:metabolism; D013234:Stem Cells / Q000201:enzymology*
D010447:Peptide Hydrolases; D020782:Matrix Metalloproteinases