Two new sesquiterpene derivatives from the Tunisian endemic Ferula tunetana Pom.
A new sesquiterpene ester, tunetanin A (1), a new sesquiterpene coumarin, tunetacoumarin A (2), together with eight known compounds, i.e., coladin (3), coladonin (4), isosmarcandin (5), 13-hydroxyfeselol (6), umbelliprenin (7) propiophenone (8), beta-sitosterol (9), and stigmasterol (10), were isolated from the roots of Ferula tunetana. Their structures were elucidated on the basis of extensive spectroscopic methods, including 1D- and 2D-NMR experiments and MS analysis, as well as by comparison with published data. The cytotoxicity of compounds 1-7 towards two human colon cancer cell lines, HT-29 and HCT 116, was evaluated. Compounds 3, 4, and 6 showed weak cytotoxic activities.
Jabrane
Aymen
A
Institut Supérieur de Biotechnologie de Monastir, Université de Monastir, 5000 Monastir, Tunisie.
Ben Jannet
Hichem
H
Mighri
Zine
Z
Mirjolet
Jean-François
JF
Duchamp
Olivier
O
Harzallah-Skhiri
Féthia
F
Lacaille-Dubois
Marie-Aleth
MA
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005309:Ferula / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013045:Species Specificity; D013329:Structure-Activity Relationship
D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins; D012717:Sesquiterpenes; C549412:tunetacoumarin A; C549411:tunetanin A