Intramolecular anodic olefin coupling reactions and the synthesis of cyclic amines.
Anodic olefin coupling reactions using a tosylamine trapping group have been studied. The cyclizations are favored by the use of a less-polar radical cation and more basic reaction conditions. The most significant factor for obtaining good yields of cyclic product is the use of the more basic reaction conditions. However, a number of factors including the nature of both the solvent and the electrolyte used can influence the yield of the cyclizations. The cyclizations allow for the rapid synthesis of both substituted proline and pipecolic acid type derivatives.
Department of Chemistry, Washington University, St. Louis, Missouri 63130, USA.
Hai-Chao
HC
Xu
Kevin D
KD
Moeller
D000475:Alkenes / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D003500:Cyclization; D004566:Electrodes; D004572:Electrolysis; D010875:Pipecolic Acids / Q000138:chemical synthesis; D011392:Proline / Q000138:chemical synthesis
D000475:Alkenes; D000588:Amines; D010875:Pipecolic Acids; D011392:Proline; C031345:pipecolic acid