Peritoneal adhesions in human and veterinary medicine: from pathogenesis to therapy. A review.
Any peritoneal inflammatory process consequent to infections or surgical injuries may induce abdominal adhesion formation. Peritoneal adhesions are connective laciniae that develop among abdomino-pelvic organs that limit physiologic visceral motion. Consequently, fertility may be impaired, and intestinal obstruction and pelvic pain may develop, mainly in subjects that had undergone gynaecological surgery. This review illustrates the pathogenic steps of adhesiogenesis and the therapeutic scenario that evolved over the years to tackle the threat of peritoneal adhesions, both in domestic animals and in women.
Department of Animal Production, Faculty of Veterinary Medicine, University of Bari, Bari, Italy.
Annalisa
A
Rizzo
Massimo
M
Spedicato
Maddalena
M
Mutinati
Giuseppe
G
Minoia
Stefano
S
Angioni
Felicita
F
Jirillo
Marianna
M
Pantaleo
Raffaele L
RL
Sciorsci
D000818:Animals; D000829:Animals, Domestic / Q000601:surgery; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D016207:Cytokines / Q000032:analysis; D005260:Female; D005298:Fertility; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects; D006801:Humans; D007415:Intestinal Obstruction / Q000188:drug therapy / Q000209:etiology; D007962:Leukocytes / Q000276:immunology; D017699:Pelvic Pain / Q000188:drug therapy / Q000209:etiology; D010538:Peritonitis / Q000473:pathology* / Q000628:therapy* / Q000662:veterinary; D000267:Tissue Adhesions / Q000473:pathology / Q000628:therapy / Q000662:veterinary
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016207:Cytokines