Effect of preoperative rectal indomethacin on postoperative pain reduction after open cholecystectomy.
The preoperative administration of nonsteroidal anti-inflammatory drugs (NSAIDs) has been shown to have a positive impact on postoperative pain, but there is little research regarding the use of rectal NSAIDs given before surgery. The purpose of this study was to evaluate the effects of rectally administered indomethacin on postoperative pain in patients undergoing open cholecystectomy. A randomized controlled design was used to compare rectally administered indomethacin with placebo. Pain intensity, total opioid dose, and postoperative time to first request for analgesic were evaluated. The indomethacin group experienced significantly less postoperative pain and required less total opioid dose compared with the placebo group. Preoperative rectal administration of indomethacin reduces postoperative pain in open cholecystectomy when compared with placebo.
Department of General Surgery, ImamRezaUniversityHospital, Surgical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Mostafa Mehrabi
MM
Bahar
Ali
A
Jangjoo
Ehsan
E
Soltani
Masoomeh
M
Armand
Samira
S
Mozaffari
D000285:Administration, Rectal; D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D016009:Chi-Square Distribution; D002763:Cholecystectomy / Q000009:adverse effects*; D015400:Clinical Nursing Research; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage*; D007492:Iran; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D011182:Postoperative Care; D011300:Preoperative Care / Q000379:methods* / Q000451:nursing; D016037:Single-Blind Method; D018709:Statistics, Nonparametric; D013997:Time Factors; D016896:Treatment Outcome
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007213:Indomethacin