The dermal-based borderline melanocytic tumor: a categorical approach.
BACKGROUND
The borderline melanocytic tumor (BMT) is a morphologically and biologically indeterminate melanocytic proliferation manifesting worrisome architectural features and cytologic atypia exceeding that encountered in melanocytic nevi yet insufficient to warrant designation as melanoma. The criteria that define the BMT are not well defined nor is the concept widely recognized.


OBJECTIVE
The purpose of this study is to provide a practical framework for the approach to the dermal BMT.


METHODS
Thirty-two patients with BMTs extending into the reticular dermis and at a depth of 0.75 mm or more underwent local excision and sentinel lymph node biopsy between 2000 and 2006. Four categories of BMT were recognized: (1) nevoid BMT (BNM); (2) the atypical Spitz tumor (AST); (3) pigmented epithelioid melanocytoma (PEM); and (4) BMT arising in a deep penetrating nevus (B-DPN).


RESULTS
Four patients were in the BNM category (male/female ratio [M:F] = 1:3; mean age = 27 years, range = 15-36), 14 in the AST category (M:F = 7:7; mean age = 20.9, range = 3-58), 7 in the PEM category (M:F = 4:3; mean age = 23.5, range = 3-39), and 7 in the B-DPN category (M:F = 5:2; mean age = 22.3, range = 14-36). The percentages of patients with positive sentinel nodes in each category were 25% (1/4), 35% (5/14), 14% (1/7), and 57% (4/7), respectively. The average time of follow-up was approximately 4.2 years. One patient, a 36-year-old man, died of disease, while the others are alive and well. In the one death attributable to widespread metastatic disease, the lesion was initially interpreted as a deep penetrating nevus; however, retrospective review revealed features compatible with a B-DPN; the review was prompted by a recurrence that was morphologically compatible with a Clark level V malignant melanoma, reflecting clinical and morphologic progression.


CONCLUSIONS
The mean follow-up was less than 5 years. Molecular studies to further explore the biologic commonality with melanoma were not performed.


CONCLUSIONS
The dermal variant of BMT is a tumor of younger adults and children that can be associated with lymph node disease and a potential for morphologic and biologic progression when inadequately treated.
Magro
Cynthia M
CM
Department of Pathology, Weill Medical College of Cornell University, 1300 York Ave, F-309, New York, NY 10021, USA. cym2003@med.cornell.edu
Crowson
A Neil
AN
Mihm
Martin C
MC
Gupta
Kapil
K
Walker
Michael J
MJ
Solomon
Garron
G
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008544:Melanocytes / Q000473:pathology; D008545:Melanoma / Q000145:classification / Q000473:pathology*; D008875:Middle Aged; D018332:Nevus, Epithelioid and Spindle Cell / Q000473:pathology; D009508:Nevus, Pigmented / Q000145:classification / Q000473:pathology; D021701:Sentinel Lymph Node Biopsy; D012878:Skin Neoplasms / Q000145:classification / Q000473:pathology*