Relevance of DNA alkylation damage repair systems in Salmonella enterica virulence.
Systematic inactivation of pathways involved in DNA alkylation damage repair demonstrated that inactivation of the ada, ogt, tag, uvrA, and mfd genes is required to detect a Salmonella enterica virulence decrease. Furthermore, the fitness of S. enterica, defective in these genes, is lowered only when the bacterium is orally, but not intraperitoneally, inoculated.
Departament de Genètica i de Microbiologia, Facultat de Biociències, Universitat Autònoma de Barcelona, Bellaterra, Spain.
Gerard
G
Alvarez
Susana
S
Campoy
Denis A
DA
Spricigo
Laura
L
Teixidó
Pilar
P
Cortés
Jordi
J
Barbé
D000478:Alkylation; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D004260:DNA Repair; D045643:DNA Repair Enzymes / Q000235:genetics* / Q000378:metabolism; D055786:Gene Knockout Techniques; D019779:Salmonella enterica / Q000378:metabolism / Q000472:pathogenicity / Q000502:physiology*; D014774:Virulence
D001426:Bacterial Proteins; D004247:DNA; D045643:DNA Repair Enzymes