Addictive potential: A=E/T(max)xt(1/2).
This hypothesis named Salerian Addictive Potential (SAP) suggests that the addictive potency of any substance may be calculated with an algebraic equation of A=E/T(max)xt(1/2), where A is the addictive potency, E represents the euphoric potency, T(max) is the time to reach peak plasma concentration, and t(1/2) is the plasma elimination half-life. This review offers medical evidence to suggest there is a negative association between the addictive potency of a substance and T(max) and t(1/2), whereas the euphoric potency of a substance increases its addictive potency. SAP seems incompatible with the current FDA and government sponsored schedule for classification of addictive substances.
Washington Center for Psychiatry, Washington, DC 20015, USA. rcolbert@salerianbrain.com
Alen J
AJ
Salerian
D000818:Animals; D016739:Behavior, Addictive; D006801:Humans; D013287:Illicit Drugs / Q000097:blood / Q000145:classification / Q000493:pharmacokinetics*; D008954:Models, Biological; D011619:Psychotropic Drugs / Q000097:blood / Q000145:classification / Q000493:pharmacokinetics; D013375:Substance Withdrawal Syndrome; D019966:Substance-Related Disorders / Q000097:blood / Q000209:etiology* / Q000523:psychology
D013287:Illicit Drugs; D011619:Psychotropic Drugs