Differential regulation of IgG-NMO autoantibodies on S100Beta protein and disability in relapsing neuromyelitis optica.
Neuromyelitis optica (NMO), an uncommon central nervous system (CNS) demyelinating disease, produces transverse myelitis and severe optic neuritis. IgG-NMO autoantibody, a specific immunoglobulin binding aquaporin-4 water channel protein, confirms that NMO is a different entity to multiple sclerosis. Parallel to cytokine down-regulations found in serum of relapsing-NMO (rNMO) patients, it has been reported that IgG-NMO may also confer a worse course of the disease in r-NMO Caribbean patients. In this study, we were interested in exploring the influence of IgG-NMO autoantibody on S100beta levels and clinical parameters from serum of r-NMO patients. Serum samples from 24 rNMO patients and 10 controls were evaluated. The reduction of S100beta observed in r-NMO patients was not significant compared to controls; and no differences were present regarding IgG-NMO immunoreactivity. At the same time, a significant correlation was also observed between IgG-NMO autoantibody serum detection and EDSS (Expanded Disability Status Scale) in rNMO. These results corroborate a differential regulation of IgG-NMO autoantibodies on the S100beta glial marker and on the disability present in rNMO patients.
Robinson-Agramonte
Maria A
MA
International Center for Neurological Restoration and Cuban Neuroimmunology Society, Havana, Cuba. maria.robinson@infomed.sld.cu
Gonçalves
Carlos Alberto Saravia
CA
Portela
L Valmor
LV
Portela
Valmor L
VL
Saiz-Hinarejos
A
A
Oses
Jean Pierre
JP
Oses
Pierre J
PJ
Motta
Luis Souza
LS
Motta
Souza L
SL
Muller
A Pastoris
AP
Marquez Gonzalez
M E
ME
Souza
Diogo Onofre
DO
Gomes de Souza
Onofre D
OD
D000328:Adult; D051401:Aquaporin 4 / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D004185:Disability Evaluation; D015536:Down-Regulation / Q000276:immunology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D056747:Immunomodulation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000032:analysis / Q000097:blood*; D009471:Neuromyelitis Optica / Q000097:blood* / Q000276:immunology* / Q000503:physiopathology; D012008:Recurrence; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000032:analysis / Q000097:blood*
C496030:AQP4 protein, human; D051401:Aquaporin 4; D001323:Autoantibodies; D015415:Biomarkers; D007074:Immunoglobulin G; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins