A case of subcorneal pustular dermatosis in association with monoclonal IgA gammopathy successfully treated with acitretin.
Subcorneal pustular dermatosis (SPD), or Sneddon-Wilkinson disease, is a rare, chronic, recurrent, pustular eruption. Association with several diseases is well known, mainly IgA and IgG gammopathies or myelomas. Although dapsone is often considered to be the first-line treatment, some patients fail to respond or cannot tolerate the side effects. For cases that do not respond well to this treatment, acitretin, an excellent second-line treatment, may be used. Herein, a 55-year-old woman with SPD associated with monoclonal IgA gammopathy refractory to dapsone is presented, who was successfully treated with acitretin in a short period.
Department of Dermatology, Ministry of Health Diskapi Yildirim Beyazit Education and Research Hospital, Ankara, Turkey. filizcanpolat@hotmail.com
Filiz
F
Canpolat
Hatice
H
Akpinar
Bengü Cevirgen
BC
Cemil
Fatma
F
Eskioğlu
Evrim
E
Oztürk
D017255:Acitretin / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007070:Immunoglobulin A; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D012872:Skin Diseases, Vesiculobullous / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*
D007070:Immunoglobulin A; D007641:Keratolytic Agents; D017255:Acitretin