Synthesis of anti-tumor dimeric indole alkaloids in catharanthus roseus was promoted by irradiation with near-ultraviolet light at low temperature.
We have found that coupling between catharanthine and vindoline occurs non-enzymatically in the presence of flavin mononucleotide and manganese ions with near-ultraviolet light irradiation in vitro. The present study found that the concentrations of catharanthine and vindoline in Catharanthus roseus decreased and those of dimeric indole alkaloids increased under near-ultraviolet light at 4 degrees C. It indicates that this coupling reaction at 4 degrees C occurs non-enzymatically.
Department of Applied Environmental Biology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Mamiko
M
Asano
Kazuo
K
Harada
Tomoaki
T
Yoshikawa
Takeshi
T
Bamba
Kazumasa
K
Hirata
D000970:Antineoplastic Agents / Q000378:metabolism*; D030008:Catharanthus / Q000378:metabolism* / Q000528:radiation effects*; D003080:Cold Temperature; D026121:Indole Alkaloids / Q000378:metabolism*; D014466:Ultraviolet Rays
D000970:Antineoplastic Agents; D026121:Indole Alkaloids