Electrospun nanofibers in oral drug delivery.
In order to enhance the delivery of drugs with limited absorption due to poor solubility/dissolution, approaches are being developed to improve the dissolution rates and solubility of drug molecules. These approaches include identification of water-soluble salts of parent drugs, preparation of stable amorphous drug formulations, inclusion of solubility-enhancing agents in the dosage form, and particle size reduction. Technologies to reduce drug particle size to sub-micrometer range are being applied to product development more frequently. Electrospinning is being considered as one of the technologies which can produce nanosized drugs incorporated in polymeric nanofibers. In vitro and in vivo studies have demonstrated that the release rates of drugs from these nanofiber formulations are enhanced compared to those from original drug substance. This technology has the potential to be used for enhancing the oral delivery of poorly soluble drugs.
Pharmaceutical Development, GlaxoSmithKline, 1250 S. Collegeville Rd, Collegeville, Pennsylvania 19426, USA. Francis.2.Ignatious@gsk.com
Francis
F
Ignatious
Linghong
L
Sun
Chao-Pin
CP
Lee
John
J
Baldoni
D000284:Administration, Oral; D016503:Drug Delivery Systems / Q000379:methods*; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000295:instrumentation / Q000379:methods; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D013678:Technology, Pharmaceutical / Q000295:instrumentation / Q000379:methods*
D004364:Pharmaceutical Preparations