Guidelines for safety management of granulocyte transfusion in Japan.
Granulocyte transfusion (GTX) has recently been revived by the ability to stimulate granulocyte donors with granulocyte colony-stimulating factor (G-CSF), resulting in a greatly increased number of cells that can be collected. However, there is a paucity of guidelines for assessing the appropriateness and safety management of GTX. The objective of this study was to establish guidelines for the safety management of GTX appropriate for the clinical situation in Japan. The Japan Society of Transfusion Medicine and Cell Therapy, Granulocyte Transfusion Task Force issued the first version of guidelines for GTX considering the safety management of both granulocyte donors and patients who receive GTX therapy. The current guidelines cover issues concerning: (1) the appropriateness of medical institutions, (2) management of granulocyte donors, (3) quality assurance of granulocyte concentrates, (4) administration of granulocyte concentrates, (5) evaluation of the effectiveness of GTX therapy, and (6) complications of GTX therapy. The simple 'bag separation method' without apheresis may be recommended for granulocyte collection in pediatric patients. The first version of guidelines for GTX therapy has been established, which may be appropriate for the clinical situation in Japan. Care should be taken to perform the safety management of both granulocyte donors and patients who receive GTX therapy.
Department of Transfusion Medicine and Stem Cell Regulation, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan. ohsaka@juntendo.ac.jp
Akimichi
A
Ohsaka
Atsushi
A
Kikuta
Hitoshi
H
Ohto
Akira
A
Ohara
Akaru
A
Ishida
Koji
K
Osada
Tetsunori
T
Tasaki
Akira
A
Kamitamari
Asayuki
A
Iwai
Shunro
S
Kai
Taira
T
Maekawa
Yasutaka
Y
Hoshi
D006098:Granulocytes / Q000637:transplantation*; D006402:Hematologic Diseases / Q000628:therapy*; D006801:Humans; D007564:Japan; D017708:Leukocyte Transfusion / Q000592:standards*; D009503:Neutropenia / Q000628:therapy*