Chemical constituents from the leaves and stems of Schisandra rubriflora.
Six new nortriterpenoids, schirubridilactones A-F (1-6), as well as 14 known compounds, were isolated from the leaves and stems of Schisandra rubriflora. The structures of 1-6 were elucidated on the basis of spectroscopic methods including HSQC, HMBC, (1)H-(1)H COSY, and ROESY NMR experiments. The relative stereochemistry of 1 was confirmed through single-crystal X-ray analysis. In addition, compounds 1-6 showed anti-HIV-1 activity with EC(50) values in the range 14.3-80.8 microg/mL and selectivity indices in the range 2.2-9.0.
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
Wei-Lie
WL
Xiao
Shi-Ying
SY
Yang
Liu-Meng
LM
Yang
Guang-Yu
GY
Yang
Rui-Rui
RR
Wang
Hai-Bo
HB
Zhang
Wei
W
Zhao
Jian-Xin
JX
Pu
Yang
Y
Lu
Yong-Tang
YT
Zheng
Han-Dong
HD
Sun
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D014315:Triterpenes