The construction of a Chinese MRI brain atlas: a morphometric comparison study between Chinese and Caucasian cohorts.
We developed a novel brain atlas template to facilitate computational brain studies of Chinese subjects and populations using high quality magnetic resonance imaging (MRI) and well-validated image analysis techniques. To explore the ethnicity-based structural brain differences, we used the MRI scans of 35 Chinese male subjects (24.03+/-2.06 years) and compared them to an age-matched cohort of 35 Caucasian males (24.03+/-2.06 years). Global volumetric measures were used to identify significant group differences in the brain length, width, height and AC-PC line distance. Using the LONI BrainParser, 56 brain structures were automatically labeled and analyzed for all subjects. We identified significant ethnicity differences in brain structure volumes, suggesting that a population-specific brain atlas may be more appropriate for studies involving Chinese populations. To address this, we constructed a 3D Chinese brain atlas based on high resolution 3.0T MRI scans of 56 right-handed male Chinese volunteers (24.46+/-1.81 years). All Chinese brains were spatially normalized by using linear and nonlinear transformation via the "AIR Make Atlas" pipeline workflow within the LONI pipeline environment. This high-resolution Chinese brain atlas was compared to the ICBM152 template, which was constructed using Caucasian brains.
Tang
Yuchun
Y
Research Center for Sectional and Imaging Anatomy, Shandong University School of Medicine, Jinan, Shandong 250012, China.
Hojatkashani
Cornelius
C
Dinov
Ivo D
ID
Sun
Bo
B
Fan
Lingzhong
L
Lin
Xiangtao
X
Qi
Hengtao
H
Hua
Xue
X
Liu
Shuwei
S
Toga
Arthur W
AW
D000328:Adult; D044466:Asian People; D001271:Atlases as Topic; D001331:Automation; D001921:Brain / Q000033:anatomy & histology*; D002681:China; D016208:Databases, Factual; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D017711:Nonlinear Dynamics; D009929:Organ Size; D044465:White People; D055815:Young Adult