B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer.
The ability of B cells to negatively regulate cellular immune responses and inflammation has only recently been described. Hallmark papers from a number of distinguished laboratories have identified phenotypically diverse B-cell subsets with regulatory functions during distinct autoimmune diseases, including IL-10-producing B cells, CD5+ B-1a cells, CD1d+ marginal zone B cells, and transitional-2-marginal zone precursor B cells. Most recently, a numerically rare and phenotypically unique CD1dhiCD5+CD19hi subset of regulatory B cells has been identified in the spleens of both normal and autoimmune mice. CD1dhiCD5+ B cells with the capacity to produce IL-10 have been named B10 cells as they produce IL-10 exclusively and are the predominant B-cell source of IL-10. Remarkably, B10 cells are potent negative regulators of inflammation and autoimmunity in mouse models of disease in vivo. Herein, our current understanding of B10-cell development and function is reviewed in the context of previous studies that have identified and characterized regulatory B cells, emerging evidence for B10-cell regulation of tumor immunity, and the likelihood that B10 cells exist in humans.
DiLillo
David J
DJ
Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA.
Matsushita
Takashi
T
Tedder
Thomas F
TF
D000818:Animals; D015551:Autoimmunity / Q000276:immunology*; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism / Q000502:physiology*; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D007109:Immunity / Q000502:physiology*; D007249:Inflammation / Q000276:immunology*; D016753:Interleukin-10 / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D009369:Neoplasms / Q000276:immunology*
D016753:Interleukin-10