New anti-malarial phenylpropanoid conjugated iridoids from Morinda morindoides.
A new phenylpropanoid conjugated iridoid together with four known congeners was isolated from Morinda morindoides, used for the therapy of malaria traditionally in some African countries, as anti-malarial principles through bioassay-guided separation. Furthermore, their absolute stereostructures were unambiguously established by a combination of modified Mosher's method and chemical correlation.
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
Satoru
S
Tamura
Bruno Kilunga
BK
Kubata
Syamsurizal
Sawako
S
Itagaki
Toshihiro
T
Horii
Muzele Kalulu
MK
Taba
Nobutoshi
N
Murakami
D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D039823:Iridoids / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D032066:Morinda / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D020005:Propanols / Q000737:chemistry*; D013237:Stereoisomerism
D000962:Antimalarials; D005960:Glucosides; D039823:Iridoids; D020005:Propanols; C439395:1-phenylpropanol