Protein kinase C: novel isozyme-selective peptide inhibitors.
Members of the protein kinase C (PKC) family play central roles in a number of important signal transduction pathways and are attractive targets in drug development for various diseases. Because of the high level of homology among its members, designing isozyme-specific PKC inhibitors has been extremely challenging. A recent patent application from the Albert Einstein College of Medicine describes a novel method by combinatorial modification of the substrate consensus sequences of an individual PKC isozyme. This approach has led to the identification of potent and isozyme-selective peptide inhibitors of PKCalpha, PKCdelta and PKCzeta.
Li
Hui
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Pfizer Global Research & Development, 10770 Science Center Dr, San Diego, CA 92121, USA.