Cell cycle: the art of multi-tasking.
Separase is the protease that cleaves the cohesive link between sister chromatids to trigger chromosome segregation in mitosis and meiosis. This enzyme is known to orchestrate additional mitotic events and we now gain new insight into how it promotes cytokinesis in the nematode Caenorhabditis elegans.
Chromosome Segregation Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London WC2A 3PX, UK.
Sandra
S
López-Avilés
Frank
F
Uhlmann
D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000201:enzymology; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D002453:Cell Cycle / Q000502:physiology*; D018797:Cell Cycle Proteins / Q000502:physiology*; D020090:Chromosome Segregation / Q000502:physiology; D048749:Cytokinesis / Q000502:physiology; D010450:Endopeptidases / Q000502:physiology*; D008954:Models, Biological; D064247:Separase
D029742:Caenorhabditis elegans Proteins; D018797:Cell Cycle Proteins; D010450:Endopeptidases; C577988:SEP-1 protein, C elegans; D064247:Separase