Dcr1 tracked down.
RNAi is essential for pericentromeric heterochromatic formation in S. pombe, and although Dcr1, the initiator protein of this process, has been biochemically well described, its subcellular localization has remained elusive. In this issue of Developmental Cell, Emmerth et al. now show that Dcr1 is dynamically shuttling between nucleus and cytoplasm, adding new insight into the subcellular mechanics of RNAi.
Hubrecht Institute-KNAW & University Medical Centre Utrecht, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.
Lucas J T
LJ
Kaaij
René F
RF
Ketting
D021581:Active Transport, Cell Nucleus / Q000235:genetics; D000818:Animals; D002467:Cell Nucleus / Q000235:genetics* / Q000378:metabolism; D003593:Cytoplasm / Q000235:genetics / Q000378:metabolism; D006570:Heterochromatin / Q000235:genetics; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics; D022022:Nuclear Pore / Q000235:genetics / Q000378:metabolism; D021381:Protein Transport; D034622:RNA Interference / Q000502:physiology*; D043244:Ribonuclease III / Q000235:genetics* / Q000378:metabolism; D012568:Schizosaccharomyces / Q000235:genetics* / Q000378:metabolism
C501513:Gid8 protein, S cerevisiae; D006570:Heterochromatin; D047908:Intracellular Signaling Peptides and Proteins; D043244:Ribonuclease III