SUMO boosts the DNA damage response barrier against cancer.
Cells exposed to genotoxic insults such as ionizing radiation activate a signaling cascade to repair the damaged DNA. Two recent articles published in Nature show that such genome maintenance requires modifications of tumor suppressor proteins BRCA1 and 53BP1 by the small ubiquitin-like modifier SUMO.
Institute of Cancer Biology and Centre for Genotoxic Stress Research, Danish Cancer Society, Strandboulevarden 49, DK-2100 Copenhagen, Denmark. jb@cancer.dk
Jiri
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Bartek
Zdenek
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Hodny
D000818:Animals; D019313:BRCA1 Protein / Q000378:metabolism; D004249:DNA Damage / Q000502:physiology*; D004260:DNA Repair / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism*; D025842:SUMO-1 Protein / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D000071857:Tumor Suppressor p53-Binding Protein 1
D019313:BRCA1 Protein; D047908:Intracellular Signaling Peptides and Proteins; D025842:SUMO-1 Protein; C498301:TP53BP1 protein, human; D000071857:Tumor Suppressor p53-Binding Protein 1