Manipulation of magnetically labeled and unlabeled cells with mobile magnetic traps.
A platform of discrete microscopic magnetic elements patterned on a surface offers dynamic control over the motion of fluid-borne cells by reprogramming the magnetization within the magnetic bits. T-lymphocyte cells tethered to magnetic microspheres and untethered leukemia cells are remotely manipulated and guided along desired trajectories on a silicon surface by directed forces with average speeds up to 20 microm/s. In addition to navigating cells, the microspheres can be operated from a distance to push biological and inert entities and act as local probes in fluidic environments.
Department of Physics, The Ohio State University, Columbus, Ohio, USA.
T
T
Henighan
A
A
Chen
G
G
Vieira
A J
AJ
Hauser
F Y
FY
Yang
J J
JJ
Chalmers
R
R
Sooryakumar
D018929:Cell Culture Techniques; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D003198:Computer Simulation; D004574:Electromagnetic Fields; D006801:Humans; D007938:Leukemia / Q000473:pathology; D008853:Microscopy / Q000295:instrumentation* / Q000379:methods*; D008863:Microspheres; D008954:Models, Biological; D009038:Motion; D012825:Silicon; D013601:T-Lymphocytes / Q000166:cytology; D014741:Video Recording
D012825:Silicon