Ethnicity-based subgroup meta-analysis of the association of LOXL1 polymorphisms with glaucoma.
OBJECTIVE
To investigate the association and ethnic heterogeneity of lysyl oxidase-like 1 (LOXL1) single nucleotide polymorphisms (SNPs) with exfoliation syndrome (XFS)/exfoliation glaucoma (XFG) and other types of glaucoma.


METHODS
We performed meta-analysis and ethnicity-based subgroup analyses according to published studies. Allele and genotype frequencies of SNPs rs1048661, rs2165241, and rs3825942 were extracted for analysis in Reviewer Manager: (1) comparison of the allelic distributions between XFS and XFG, (2) allelic association of LOXL1 SNPs with XFS/XFG, (3) associations in homozygote, heterozygote, and dominant and recessive models, and (4) allelic association with primary open angle glaucoma (POAG).


RESULTS
In total 24 reported articles were retrieved, including Caucasian, African, Japanese, Indian, and Chinese populations. There was no significant difference in the distributions of rs1048661, rs2165241, and rs3825942 between XFS and XFG. The G allele of rs3825942 was the common at-risk allele for XFS/XFG in all populations with a total odds ratio (OR) of 10.89. The total homozygote OR of rs3825942 was 9.06 for XFS/XFG combined, but the total heterozygote OR was not significant. We also found that in the recessive model, the total OR was 14.70. There was no association of the three SNPs with POAG.


CONCLUSIONS
The association of rs3825942, but not rs2165241 or rs1048661, with XFS/XFG is consistent in different ethnic populations in the recessive model. LOXL1 is not associated with POAG in all study populations.
Joint Shantou International Eye Center, Shantou University & the Chinese University of Hong Kong, Shantou, China. drchenhaoyu@gmail.com
Haoyu
H
Chen
Li Jia
LJ
Chen
Mingzhi
M
Zhang
Weifeng
W
Gong
Pancy Oi Sin
PO
Tam
Dennis Shun Chiu
DS
Lam
Chi Pui
CP
Pang
D000368:Aged; D000594:Amino Acid Oxidoreductases / Q000235:genetics*; D015331:Cohort Studies; D017889:Exfoliation Syndrome / Q000150:complications / Q000201:enzymology / Q000208:ethnology / Q000235:genetics; D005260:Female; D005799:Genes, Dominant / Q000235:genetics; D005808:Genes, Recessive / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005902:Glaucoma, Open-Angle / Q000150:complications / Q000201:enzymology / Q000208:ethnology* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D000594:Amino Acid Oxidoreductases; C445313:LOXL1 protein, human