Synthesis of the Naturally Occurring (-)-1,3,5-Tri-O-Caffeoylquinic Acid.
Ribonuclease H (RNase H) is an essential component to the replication of human immunodeficiency virus (HIV), and only a few inhibitors of this enzyme are known. Millenia Hope Pharmaceuticals Inc. found that (-)-1,3,5-tri-O-caffeoylquinic acid is a potent RNase H inhibitor and antiviral agent. A facile route leading to this inhibitor from commercially available (-)-quinic acid is reported within.
Brummond
Kay M
KM
Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA Fax +1(412)6248611; kbrummon@pitt.edu.
Deforrest
Jolie E
JE