Age-related change of serum angiogenic factor levels in patients with coronary artery disease.
OBJECTIVE
Vascular endothelial growth factor (VEGF), angiopoietin (Ang)-1 and -2 regulate angiogenesis and might be important in myocardial collateral development. Elevated levels of angiogenic growth factors in patients with coronary artery disease (CAD) have been reported. However, the age-related change of angiogenic growth factors in patients with CAD remains unclear.


RESULTS
Serum VEGF, Ang-1 and -2 levels were measured by enzyme-linked immunosorbent assay kits. Serum VEGF, Ang-1 and -2 levels in patients with CAD were significantly higher than those in healthy control subjects. In patients aged <61 years and 61 to 70 years, serum Ang-1 and -2 levels were significantly higher than in patients aged >70 years, serum Ang-2 levels in patients aged <61 years were significantly higher than in patients aged from 61 to 70 years. Serum VEGF levels were not significantly different in the three age groups. Serum VEGF, Ang-1 and -2 levels were not significantly different across the age groups in healthy subjects. Regression analysis showed that there was a negative correlation between age and Ang-1 and -2 in patients with CAD.


CONCLUSIONS
Serum Ang-1 and -2 levels, but notVEGF levels in patients with CAD, are decreased along with advancing age.
Dept. of Cardiology, The First Affiliated Hospital of Sun Yat-sen University, PR China.
Rongsen
R
Meng
Zhaohui
Z
Pei
Bo
B
Chen
Rui
R
Ma
Chengxi
C
Zhang
Baolin
B
Chen
Aixia
A
Zhang
Tongguo
T
Wu
Dan
D
Liu
Yugang
Y
Dong
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D042683:Angiopoietin-1 / Q000097:blood*; D042702:Angiopoietin-2 / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006801:Humans; D016014:Linear Models; D008875:Middle Aged; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
D042683:Angiopoietin-1; D042702:Angiopoietin-2; D042461:Vascular Endothelial Growth Factor A