Protective effects of kaempferol (3,4',5,7-tetrahydroxyflavone) against amyloid beta peptide (Abeta)-induced neurotoxicity in ICR mice.
To determine the effects of kaempferol, rat pheochromocytoma cells (PC12) and Institute of Cancer Research (ICR) mice were utilized as neuronal models. Using in vitro assays, kaempferol was shown to have protective effects against oxidative stress-induced cytotoxicity in PC12 cells. Administration of kaempferol also significantly reversed amyloid beta peptide (Abeta)-induced impaired performance in a Y-maze test. Taken altogether, the results reported here suggest that further investigation is warranted of the influence of kaempferol on pathways related to Alzheimer's disease.
Kim
Jae Kyeom
JK
Department of Food and Biotechnology, Korea University, Seoul, Republic of Korea.
Choi
Soo Jung
SJ
Cho
Hong Yon
HY
Hwang
Han-Joon
HJ
Kim
Young Jun
YJ
Lim
Seung Taik
ST
Kim
Chang-Ju
CJ
Kim
Hye Kyung
HK
Peterson
Sabrina
S
Shin
Dong-Hoon
DH
D000544:Alzheimer Disease / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism* / Q000494:pharmacology*; D000818:Animals; D044949:Kaempferols / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018696:Neuroprotective Agents / Q000494:pharmacology*; D020258:Neurotoxicity Syndromes / Q000378:metabolism*
D016229:Amyloid beta-Peptides; D044949:Kaempferols; D018696:Neuroprotective Agents; C006552:kaempferol