[Effect of lipid metabolism disturbances on electrophysiologic heart remodeling in patients with hypertensive disease].
The aim of the study was to evaluate effect of disturbed lipid metabolism on dispersion of QT interval, signal-averaged ECG characteristics, and cardiac rhythm variability as indicators of electrophysiological remodeling of myocardium in patients with HD. The study included 111 patients aged 30-73 (mean 51.4 +/- 10.7) years with stage I-II HD. All of them were examined by 12-lead ECG and high-resolution ECG with the analysis of late atrial (LAP) and ventricular (LVP) potentials. Cardiac rhythm variability (CRV) was evaluated. Analysis of standard ECG parameters depending on lipid metabolism revealed significantly higher dispersion of corrected QT interval in patients with hypercholesterolemia. High-resolution ECG showed LAP in 16 (25%) patients with hypercholesterolemia compared with 11% among patients with normal serum cholesterol (chi2 = 2.8; p = 0.042). LVPs were documented in 41, 34, 31, and 26% of the patients with high, moderately elevated, low, and normal serum cholesterol respectively. The difference was confirmed by respective changes of certain parameters of high-resolution ECG in the same patients.
Gimaev
R Kh
RKh
Ruzov
V I
VI
Razin
V A
VA
Boluchevskiĭ
D N
DN
Verushkina
A S
AS
Siapukova
A A
AA
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000502:physiology; D050171:Dyslipidemias / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D020257:Ventricular Remodeling / Q000502:physiology*
D008055:Lipids