Reactions of oxetan-3-tert-butylsulfinimine for the preparation of substituted 3-aminooxetanes.
The oxetane ring is useful in drug discovery as a bioisostere for both the geminal dimethyl group and the carbonyl group. A convenient, straightforward approach to access structurally diverse 3-aminooxetanes through the reactivity of oxetan-3-tert-butylsulfinimine and the corresponding sulfinylaziridine is described.
Department of Chemistry, Merck and Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.
Philip J
PJ
Hamzik
Jason D
JD
Brubaker
D004988:Ethers, Cyclic / Q000737:chemistry*; D007097:Imines / Q000737:chemistry; D013452:Sulfonium Compounds / Q000737:chemistry
D004988:Ethers, Cyclic; D007097:Imines; D013452:Sulfonium Compounds; C549487:oxetan-3-tert-butylsulfinimine; C522016:sulfinimine; C005287:oxetane