New structures, chemical functions, and inhibitors for glycosyltransferases.
Glycosyltransferases are key enzymes in a range of biological processes. The last two years have seen a new appreciation for the range of structural folds that can be adopted by this class of enzymes in addition to continued work in solving the structures of more varieties of these proteins, delineating their chemical function, and designing inhibitors of their catalytic function.
Roychoudhury
Rajarshi
R
Department of Chemistry and the Plant Sciences Institutes, Iowa State University, 2756 Gilman, Ames, IA 50011, USA.
Pohl
Nicola L B
NL
D000818:Animals; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D016695:Glycosyltransferases / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D010940:Plant Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation
D001426:Bacterial Proteins; D010940:Plant Proteins; D016695:Glycosyltransferases