The dance of the perivascular and endothelial cells: mechanisms of brain response to immune signaling.
The mechanisms underlying the brain response to systemic inflammation remain unclear. In this issue of Neuron, Serrats and colleagues demonstrate that two cell types that produce prostaglandins that act on the brain, perivascular and endothelial cells, have an unexpectedly complex interaction in regulating the timing and types of brain responses that occur.
Department of Neurology, Program in Neuroscience, and Division of Sleep Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. csaper@bidmc.harvard.edu <csaper@bidmc.harvard.edu>
Clifford B
CB
Saper
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000166:cytology / Q000276:immunology / Q000502:physiology; D051546:Cyclooxygenase 2 / Q000378:metabolism; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007249:Inflammation / Q000378:metabolism; D007375:Interleukin-1 / Q000276:immunology; D011453:Prostaglandins / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*
D007375:Interleukin-1; D011453:Prostaglandins; D051546:Cyclooxygenase 2