Spanish experience in autologous chondrocyte implantation.
BACKGROUND
The Spanish Ministry of Health commissioned the Galician Agency for Health Technology Assessment to monitor and follow-up Autologous Chondrocyte Implantation (ACI) used to treat chondral lesions of the knee in Spain. The objective of this monitoring was to assess efficacy and safety of the technique.


METHODS
One-hundred and eleven consecutive patients with knee chondral lesions were included in a multi-center study between January 2001 and January 2005. ACI was used in these patients as a second-line treatment option (or a first-line treatment option if the cause was Osteocondritis dissecans). The Cincinnati score and the Short Form 36 (SF-36) questionnaire were used to assess the patients' self-reported satisfaction with the outcomes of ACI. A descriptive analysis was performed and non-parametric tests were used to establish correlations and compare results among subgroups. A multivariate analysis was also performed to measure the effect of different variables on changes in the condition of the knee.


RESULTS
Eighty men (72%) and 31 women (21%) with an age range from 16 to 49 years, underwent ACI surgery. Among these subjects, the most common previous first-line treatment was debridement (64 individuals, 74.4%). The mean size of the lesion treated with ACI was 3.82 cm(2), and the most frequent location of the lesion was the inner femoral condyle (53.6%). The patient satisfaction was high or very high in 36 subjects (66.7%). Overall knee joint assessment improved from 4.32 points to 6.78. All SF-36 questionnaire categories improved, notably those related to physical condition.


CONCLUSIONS
The results of this study indicate that ACI is safe; however, further studies are mandated to assess the efficacy of ACI compared to alternative treatment options.
Galician Agency for Health Technology Assessment, Santiago de Compostela, Spain.
Santiago
S
Pérez-Cachafeiro
Alberto
A
Ruano-Raviña
José
J
Couceiro-Follente
Jose Antonio
JA
Benedí-Alcaine
Ignacio
I
Nebot-Sanchis
Ciriaco
C
Casquete-Román
Santiago
S
Bello-Prats
Gonzalo
G
Couceiro-Sánchez
Francisco J
FJ
Blanco