Enantioselective construction of lactone[2,3-b]piperidine skeletons via organocatalytic tandem reactions.
A highly enantioselective construction of delta- and gamma-lactone[2,3-b]piperidine skeletons was accomplished by tandem aza-Diels-Alder reaction-hemiacetal formation-oxidation from N-Tos-1-aza-1,3-butadienes and aliphatic dialdehydes.
State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Zhao-Quan
ZQ
He
Bo
B
Han
Rui
R
Li
Li
L
Wu
Ying-Chun
YC
Chen
D002070:Butadienes / Q000138:chemical synthesis*; D002384:Catalysis; D003500:Cyclization; D007783:Lactones / Q000737:chemistry*; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry; D010880:Piperidines / Q000737:chemistry*; D013237:Stereoisomerism; D015018:Ytterbium / Q000737:chemistry
D002070:Butadienes; D007783:Lactones; D010880:Piperidines; C032727:piperidine; C031763:1,3-butadiene; D015018:Ytterbium; D010100:Oxygen