Exceptional oral manifestations of amyloid light chain protein (AL) systemic amyloidosis.
Oral amyloidosis is usually presented in the tongue and is often associated with multiple myeloma. We present three patients with unusual oral manifestations of primary amyloidosis, which to the best of our knowledge have not been previously published. In two cases the oral manifestation was overt at the time of diagnosis and all cases ended in patient mortality. Since these oral manifestations can contribute to the diagnosis of systemic amyloidosis, clinicians should be made aware of them. Future research should assess the significance of oral manifestation as a prognostic indicator.
Elad
Sharon
S
Department of Oral Medicine, Hebrew University-Hadassah School of Dental Medicine, Jerusalem, Israel. sharon.elad@ekmd.huji.ac.il
Czerninski
Rakefet
R
Fischman
Stuart
S
Keshet
Na'ama
N
Drucker
Scott
S
Davidovich
Tzipporah
T
Goldschmidt
Neta
N
D000368:Aged; D000682:Amyloid / Q000378:metabolism*; D000686:Amyloidosis / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D005776:Gaucher Disease / Q000150:complications; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D009101:Multiple Myeloma / Q000150:complications
D000682:Amyloid; D007147:Immunoglobulin Light Chains