Biomimetic syntheses of the neurotrophic natural products caryolanemagnolol and clovanemagnolol.
Separate short and modular syntheses of the isomeric natural products caryolanemagnolol and clovanemagnolol have been achieved starting from commercially available (-)-caryophyllene. The postulated biosynthetic pathways guided the syntheses of the neuroregenerative small molecules allowing their assembly in as few as two steps.
Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station, Austin Texas 78712, USA.
Xu
X
Cheng
Nicole L
NL
Harzdorf
Travis
T
Shaw
Dionicio
D
Siegel
D001688:Biological Products / Q000096:biosynthesis / Q000138:chemical synthesis* / Q000737:chemistry; D032701:Biomimetics; D008968:Molecular Conformation; D009414:Nerve Growth Factors / Q000096:biosynthesis / Q000138:chemical synthesis* / Q000737:chemistry; D010636:Phenols / Q000138:chemical synthesis* / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
D001688:Biological Products; D009414:Nerve Growth Factors; D010636:Phenols; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C549995:caryolanemagnolol; C549996:clovanemagnolol; C024714:caryophyllene