Rationale for treatment and therapeutic options in Cushing's disease.
Cushing's disease results from prolonged overexposure of tissues to endogenous glucocorticoids, secondary to adrenocorticotrophin excess from the pituitary. Common clinical signs and symptoms include weight gain, hypertension, and osteoporosis. Effective treatment of Cushing's disease can normalize biochemical levels, reverse comorbidities, and improve overall survival and quality of life. Treatment options include pituitary or adrenal surgery, radiotherapy, and various medical therapies, but each has important limitations. Medical therapies that effectively target the pituitary tumour are urgently needed.
Stewart
Paul M
PM
Centre for Endocrinology, Diabetes and Metabolism, Clinical & Experimental Medicine, College of Medical & Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK. p.m.stewart@bham.ac.uk
Petersenn
Stephan
S
D049913:ACTH-Secreting Pituitary Adenoma / Q000188:drug therapy / Q000601:surgery; D000236:Adenoma / Q000188:drug therapy / Q000601:surgery; D000315:Adrenalectomy; D002755:Choice Behavior; D003131:Combined Modality Therapy; D000075202:Contraindications; D013507:Endocrine Surgical Procedures / Q000379:methods; D006727:Hormone Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008797:Metyrapone / Q000627:therapeutic use; D008875:Middle Aged; D047748:Pituitary ACTH Hypersecretion / Q000628:therapy*; D011908:Rationalization
D006727:Hormone Antagonists; D008797:Metyrapone