FcepsilonRIalpha gene (FCER1A) promoter polymorphisms and total serum IgE levels in Japanese atopic dermatitis patients.
Two promoter polymorphisms of the high-affinity IgE receptor alpha-subunit (FcepsilonRIalpha) gene (FCER1A), -66T>C (rs2251746) and -315C>T (rs2427827), were analysed in Japanese atopic dermatitis subjects. Patients with the -315CT/TT genotype tended to have higher total serum IgE levels, while the proportion of -315CT/TT genotype or the -315T allele was significantly higher in those with highly elevated total serum IgE concentrations.
Niwa
Y
Y
Atopy (Allergy) Research Center, Department of Dermatology, Juntendo University School of Medicine, Tokyo, Japan.
Potaczek
D P
DP
Kanada
S
S
Takagi
A
A
Shimokawa
N
N
Ito
T
T
Mitsuishi
K
K
Okubo
Y
Y
Tajima
M
M
Hobo
A
A
Ng
W
W
Tsuboi
R
R
Ikeda
S
S
Ogawa
H
H
Okumura
K
K
Nishiyama
C
C
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D003876:Dermatitis, Atopic / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007564:Japan; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D017455:Receptors, IgE / Q000235:genetics*; D055815:Young Adult
C475664:FCER1A protein, human; D017455:Receptors, IgE; D007073:Immunoglobulin E