Solventless visible light-curable coating: I. Critical formulation and processing parameters.
Film coating is generally accomplished by spraying polymers dissolved in solvents onto a cascading bed of tablets. The limitations associated with the use of solvents (both aqueous and organic) can be overcome by the use of solventless coating technologies. In this proposed solventless photocurable film coating system, each layer of coating onto the pellets (non-pareil beads) was formed using liquid photocurable monomer, powdered pore-forming agents, photosensitizers and photoinitiators in a mini-coating pan and later cured by visible light. Yield, coating efficiency, variation in color, diameter and roundness were determined for each batch to evaluate process efficiency and coating quality. It was found that the ratio (S/L ratio) of the amount of solid (S) pore-forming agent to volume of liquid (L) monomer, particle size and type of the pore-forming agent, concentration of initiator, and total exposure (light intensity x exposure time) of light were critical formulation and processing parameters for the process. Using lactose as a pore-forming agent, an optimum ratio of pore-forming agent to photocurable polymer was 1.8-3.0 to achieve good process efficiency and uniformity. The ratio was sensitive to particle size and type of pore-forming agent.
Department of Pharmaceutical Sciences, School of Pharmacy, University of Connecticut, 69 North Eagleville Road, Storrs, Connecticut 06269, United States. bosesagarika@gmail.com
Sagarika
S
Bose
Robin H
RH
Bogner
D017438:Bisphenol A-Glycidyl Methacrylate / Q000737:chemistry / Q000528:radiation effects*; D002626:Chemistry, Pharmaceutical; D003116:Color; D004304:Dosage Forms; D004339:Drug Compounding; D006244:Hardness; D007785:Lactose / Q000737:chemistry; D008027:Light; D008689:Methacrylates / Q000737:chemistry; D008956:Models, Chemical; D010316:Particle Size; D055668:Photochemical Processes; D017319:Photosensitizing Agents / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry / Q000528:radiation effects*; D011109:Polymethacrylic Acids / Q000737:chemistry / Q000528:radiation effects*; D016062:Porosity; D013213:Starch / Q000031:analogs & derivatives / Q000737:chemistry; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods*; D013729:Terpenes / Q000737:chemistry; D013997:Time Factors; D014783:Viscosity
D004304:Dosage Forms; D008689:Methacrylates; D017319:Photosensitizing Agents; D011109:Polymethacrylic Acids; D013729:Terpenes; C020946:triethylene glycol dimethacrylate; D011092:Polyethylene Glycols; D017438:Bisphenol A-Glycidyl Methacrylate; C048339:camphoroquinone; D013213:Starch; C048390:sodium starch glycolate; D007785:Lactose; C049840:2-(dimethylamino)ethyl methacrylate