Perinatal nutrient restriction reduces nephron endowment increasing renal morbidity in adulthood: a review.
Perinatal malnutrition has been included among the causes of renal disease in adulthood. Here, we consider the relationships between early supply of specific nutrients (such as protein, fat, vitamins and electrolytes) and renal endowment. Prenatal and postnatal nutrition mismatch is also discussed. In addition, this article presents the role of nutrition of both mothers and pre-term infants on nephron endowment, with final practical considerations.
Neonatal Intensive Care Unit, Puericultura Institute and Neonatal Section, University and Azienda Mista of Cagliari, Italy. vafanos@tin.it
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Fanos
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Puddu
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Reali
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Atzei
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Zaffanello
D000328:Adult; D017668:Age of Onset; D031204:Caloric Restriction / Q000009:adverse effects; D005260:Female; D048070:Fetal Nutrition Disorders / Q000453:epidemiology; D006801:Humans; D007231:Infant, Newborn; D007674:Kidney Diseases / Q000453:epidemiology* / Q000209:etiology*; D044342:Malnutrition / Q000150:complications* / Q000151:congenital* / Q000453:epidemiology; D039382:Maternal Nutritional Physiological Phenomena; D009017:Morbidity; D009399:Nephrons / Q000196:embryology / Q000254:growth & development* / Q000502:physiology; D011247:Pregnancy