The role of mucin-type O-glycans in eukaryotic development.
Newly emerging genetic studies have revealed that a subset of the family of glycosyltransferases responsible for the formation of mucin-type O glycans is essential for normal development. As additional genetic, biochemical and physical tools are developed to interrogate the complex structure and surface location of this under-studied class of carbohydrate, no doubt additional roles will be elucidated.
Section on Biological Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA. tabakl@mail.nih.gov
Lawrence A
LA
Tabak
D056890:Eukaryota / Q000502:physiology*; D006031:Glycosylation; D016695:Glycosyltransferases / Q000378:metabolism; D009077:Mucins / Q000737:chemistry / Q000378:metabolism*; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism*
D009077:Mucins; D011134:Polysaccharides; D016695:Glycosyltransferases