Development of monocytes, macrophages, and dendritic cells.
Monocytes and macrophages are critical effectors and regulators of inflammation and the innate immune response, the immediate arm of the immune system. Dendritic cells initiate and regulate the highly pathogen-specific adaptive immune responses and are central to the development of immunologic memory and tolerance. Recent in vivo experimental approaches in the mouse have unveiled new aspects of the developmental and lineage relationships among these cell populations. Despite this, the origin and differentiation cues for many tissue macrophages, monocytes, and dendritic cell subsets in mice, and the corresponding cell populations in humans, remain to be elucidated.
Geissmann
Frederic
F
Centre for Molecular and Cellular Biology of Inflammation, Division of Immunology, Infection, and Inflammatory Diseases, King's College London, Great Maze Pond, London SE1 1UL, UK. frederic.geissmann@kcl.ac.uk
Manz
Markus G
MG
Jung
Steffen
S
Sieweke
Michael H
MH
Merad
Miriam
M
Ley
Klaus
K
D000818:Animals; D019070:Cell Lineage; D049109:Cell Proliferation; D016207:Cytokines / Q000378:metabolism; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008264:Macrophages / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D051379:Mice; D009000:Monocytes / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D023461:Myeloid Progenitor Cells / Q000166:cytology / Q000502:physiology; D038042:Myelopoiesis; D010587:Phagocytosis; D014158:Transcription, Genetic
D016207:Cytokines