Abnormal P-wave morphology is a predictor of atrial fibrillation development and cardiac death in MADIT II patients.
BACKGROUND
Several ECG-based approaches have been shown to add value when risk-stratifying patients with congestive heart failure, but little attention has been paid to the prognostic value of abnormal atrial depolarization in this context. The aim of this study was to noninvasively analyze the atrial depolarization phase to identify markers associated with increased risk of mortality, deterioration of heart failure, and development of atrial fibrillation (AF) in a high-risk population with advanced congestive heart failure and a history of acute myocardial infarction.


METHODS
Patients included in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT II) with sinus rhythm at baseline were studied (n = 802). Unfiltered and band-pass filtered signal-averaged P waves were analyzed to determine orthogonal P-wave morphology (prespecified types 1, 2, and 3/atypical), P-wave duration, and RMS20. The association between P-wave parameters and data on the clinical course and cardiac events during a mean follow-up of 20 months was analyzed.


RESULTS
P-wave duration was 139 + or - 23 ms and the RMS20 was 1.9 + or - 1.1 microV. None of these parameters was significantly associated with poor cardiac outcome or AF development. After adjustment for clinical covariates, abnormal P-wave morphology was found to be independently predictive of nonsudden cardiac death (HR 2.66; 95% CI 1.41-5.04, P = 0.0027) and AF development (HR 1.75; 95% CI 1.10-2.79, P = 0.019).


CONCLUSIONS
Abnormalities in P-wave morphology recorded from orthogonal leads in surface ECG are independently predictive of increased risk of nonsudden cardiac death and AF development in MADIT II patients.
Department of Cardiology, Lund University Hospital, SE-221 85 Lund, Sweden. fredrik.holmqvist@med.lu.se
Fredrik
F
Holmqvist
Pyotr G
PG
Platonov
Scott
S
McNitt
Slava
S
Polonsky
Jonas
J
Carlson
Wojciech
W
Zareba
Arthur J
AJ
Moss
D001281:Atrial Fibrillation / Q000150:complications / Q000175:diagnosis*; D003643:Death; D017147:Defibrillators, Implantable; D004562:Electrocardiography / Q000379:methods* / Q000706:statistics & numerical data*; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000150:complications* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000628:therapy; D017202:Myocardial Ischemia / Q000150:complications; D011237:Predictive Value of Tests; D012307:Risk Factors