Selective detection of dopamine in the presence of ascorbic acid using carbon nanotube modified screen-printed electrodes.
This work reports on the performance of carbon nanotube modified screen-printed electrodes (SPE-MWCNT) for the selective determination of dopamine (DA) in the presence of ascorbic acid (AA) by adsorptive stripping voltammetry (AdSV). Several operating conditions and parameters were examined including the electrochemical pre-treatment and the previous AA interaction and DA accumulation in the presence AA at physiological conditions. Under the chosen conditions, DA peak current of differential pulse voltammograms increases linearly with DA concentration in the range of 5.0 x 10(-8) to 1.0 x 10(-6) mol L(-1) with a limit of detection of 1.5 x 10(-8) mol L(-1) in connection with 600s accumulation time. The sensitivity obtained for DA was independent from the presence or absence of AA; therefore, the proposed method can be readily applied to detect DA in real samples. The proposed methodology was successfully used for the quantification of DA in urine samples.
Moreno
Mónica
M
Dpto. Química Analítica y Análisis Instrumental, Universidad Autónoma de Madrid, 28049 Madrid, Spain. monica.moreno@uam.es
Arribas
Alberto Sánchez
AS
Bermejo
Esperanza
E
Chicharro
Manuel
M
Zapardiel
Antonio
A
Rodríguez
Marcela C
MC
Jalit
Yamile
Y
Rivas
Gustavo A
GA
D001205:Ascorbic Acid / Q000032:analysis / Q000652:urine*; D004298:Dopamine / Q000032:analysis / Q000652:urine*; D004563:Electrochemistry / Q000295:instrumentation* / Q000379:methods; D004566:Electrodes; D006801:Humans; D057230:Limit of Detection; D037742:Nanotubes, Carbon / Q000737:chemistry*
D037742:Nanotubes, Carbon; D001205:Ascorbic Acid; D004298:Dopamine