No association between the FXYD6 gene and schizophrenia in the Chinese Han population.
Choudhury et al. identified FXYD6 as a susceptible gene for schizophrenia in the London and Aberdeen populations. We genotyped D11S1998 and 8 SNPs (rs869789, rs11216567, rs10790212, rs876797, rs4938445, rs497768, rs11216598, rs11605223) in a Chinese sample consisting of 1514 schizophrenia patients and 1514 healthy controls. We also compared the expression levels of FXYD6 in lymphocytes in 86 schizophrenia patients and 94 controls. No association was detected either in D11S1998 or the 8 SNPs. No difference was found in expression level between patients and controls. Our study suggests that FXYD6 does not play a role in schizophrenia in the Chinese Han population.
Zhang
Jing
J
Bio-X Center, Shanghai Jiao Tong University, 1954 Huashan Road, Shanghai 200030, PR China.
Che
Ronglin
R
Li
Xingwang
X
Tang
Wei
W
Zhao
Qian
Q
Tang
Ruqi
R
Wang
Yang
Y
Zhang
Zhao
Z
Ji
Jue
J
Yang
Fengping
F
Shi
Yongyong
Y
Ji
Weidong
W
Zhou
Guoquan
G
Feng
Guoyin
G
He
Lin
L
He
Guang
G
D000328:Adult; D002681:China / Q000453:epidemiology; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*
C531119:FXYD6 protein, human; D007473:Ion Channels