Failure of the GnRH antagonist ganirelix to block the positive feedback effect of exogenous estrogen in normal women.
This study investigated whether the GnRH antagonist ganirelix is able to block the positive-feedback effect of E2 in normal women. Ganirelix was unable to block the positive-feedback effect, suggesting that the clinical efficacy of GnRH antagonists in IVF cycles is determined by the hyperstimulation process.
Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece. Electronic address: messinis@med.uth.gr.
Ioannis E
IE
Messinis
Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece.
Polyxeni
P
Vanakara
Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece.
Apostolos
A
Zavos
Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece.
Christina
C
Verikouki
Department of Nuclear Medicine, Medical School, University of Thessalia, Larissa, Greece.
Panagiotis
P
Georgoulias
Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece.
Konstantinos
K
Dafopoulos
D000279:Administration, Cutaneous; D000328:Adult; D004958:Estradiol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D025461:Feedback, Physiological / Q000187:drug effects*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology / Q000627:therapeutic use; D006262:Health; D006727:Hormone Antagonists / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood / Q000187:drug effects; D010062:Ovulation Induction; D011374:Progesterone / Q000097:blood; D017211:Treatment Failure
D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol; C061018:ganirelix