The integrity of corpus callosum and cluster B personality disorders: a quantitative MRI study in juvenile myoclonic epilepsy.
Evidence suggests increased prevalence of cluster B personality disorders (PD) among patients with juvenile myoclonic epilepsy (JME), which has been associated with worse seizure control and more psychosocial dysfunctions. A preliminary voxel-based morphometry study demonstrated corpus callosum (CC) volume reduction in patients with JME and cluster B PD, particularly in the posterior midbody and isthmus. In this study we aimed to follow up these results with region of interest analysis. Sixteen JME patients with cluster B PD, 38 JME patients without any psychiatric disorder, and 30 demographically matched healthy controls submitted to a psychiatric evaluation and a magnetic resonance imaging scan. The total and regional callosal areas were obtained from the midsagittal slice using a semi-automated program. Psychiatric evaluation was performed through SCID-I and -II. Significant reductions in the posterior region of the CC were observed in the JME with PD group relative to the other groups. These data support previous findings of callosal reductions in cluster B PD, as well as a possible involvement of CC in patients with JME and such personality characteristics.
Department of Neurology, Universidade Federal de São Paulo/UNIFESP, São Paulo, Brazil. filho.gerardo@gmail.com
Gerardo Maria de Araújo
GM
Filho
Andrea Parolin
AP
Jackowski
Katia
K
Lin
Ivaldo
I
Silva
Mirian
M
S B Guaranha
Laura M F F
LM
Guilhoto
Henrique Carrete
HC
Júnior
Elza Márcia T
EM
Yacubian
Rodrigo Affonseca
RA
Bressan
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001931:Brain Mapping; D016022:Case-Control Studies; D003337:Corpus Callosum / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D020190:Myoclonic Epilepsy, Juvenile / Q000150:complications / Q000473:pathology*; D010554:Personality Disorders / Q000150:complications / Q000473:pathology*; D010555:Personality Inventory; D011569:Psychiatric Status Rating Scales; D012189:Retrospective Studies; D055815:Young Adult