[Analysis of the clinical outcomes of 160 patients undergoing repeated IVF/ICSI-ET treatment].
OBJECTIVE
To study the clinical factors affecting the outcomes of repeated assisted reproductive technology (ART) cycles.


METHODS
A retrospective analysis of the clinical data and outcomes was conducted among 160 patients undergoing repeated IVF/ICSI-ET treatment between January 2006 and April 2009.


RESULTS
The patients with successful clinical pregnancy after two ART cycles (group A) had a younger age and shorter duration of infertility, and had more antral follicles (AFC), more eggs and good-quality embryos with more transferred embryos available and higher good-quality embryo rate (P<0.05) than those who failed to have pregnancy after the cycles (group B). In the second cycle, the patients in group A had higher doses of short-acting GnRHa, r-HCG and HMG and at the same time more good eggs and embryos than in the first cycle.


CONCLUSIONS
Female age is one of the most important factors affecting the pregnancy rate after repeated ART cycles. The clinical pregnancy rate can be enhanced by administering short-acting GnRHa, HMG, oral contraceptives and adjusting the dose of Gn as well as changing the culture medium of embryos.
Li
Qiu-hua
QH
Center of Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. liqiuhua1320@yahoo.com.cn
Quan
Song
S
Chen
Lei-ning
LN
Li
Hong
H
Gao
Rui-hua
RH
Ni
Hao
H
Yu
Min
M
Chen
Si-mei
SM
Luo
Chen
C
D000328:Adult; D000367:Age Factors; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D012189:Retrospective Studies
D007987:Gonadotropin-Releasing Hormone