Alternative splicing of SMADs in differentiation and tissue homeostasis.
Tissue-specific alternate splicing is an important means of regulating gene expression during development. The effector proteins for the transforming growth factor-beta signaling pathway, the SMADs, encode distinct isoforms generated via alternate splicing, which appear to have distinct tissue-specific expression profiles and functions. Here, we discuss the roles of various SMAD isoforms, and the consequences of mis-regulation of SMAD splicing in development and tissue homeostasis.
Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore, Singapore.
Shijie
S
Tao
Karuna
K
Sampath
D017398:Alternative Splicing; D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D020869:Gene Expression Profiling; D006412:Hematopoietic Stem Cells / Q000378:metabolism; D006706:Homeostasis / Q000235:genetics*; D006801:Humans; D020033:Protein Isoforms / Q000235:genetics; D051785:Smad Proteins / Q000235:genetics*; D051902:Smad5 Protein / Q000235:genetics
D020033:Protein Isoforms; D051785:Smad Proteins; D051902:Smad5 Protein