[Differential therapy of arterial hypertension based on the analysis of cardiac rhythm variability].
The study was designed for spectral analysis of cardiac rhythm variability (CRV) in practically healthy subjects and patients with AH. Classification of oscillatory cardiac rhythm activity is proposed based on CRV characteristics in four frequency ranges, viz. ultralow frequency (ULF), very low frequency (VLF), low frequency (LF), and high frequency (HF). Three types of CRV are distinguished (low, medium, and high-amplitude). Differential hypotensive therapy is recommended depending on the initial CRV level. Patients with AH and markedly narrowed CRV spectrum should be treated with beta-adrenoblockers, those with moderate and elevated CRV with ACE inhibitors and calcium antagonists respectively. Modern computer technologies for the analysis of slow-wave events in blood circulation may be used to evaluate regulatory process and thereby to facilitate the choice of adequate therapy.
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Naumova
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology*; D015716:Electrocardiography, Ambulatory; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D002121:Calcium Channel Blockers