Intrathecal sufentanil for intraoperative and postesophagectomy pain relief.
OBJECTIVE
The present study compares the analgesic properties of intrathecal (IT group) and intravenous (IV group) sufentanil in postoperative pain relief.


METHODS
This randomized, single blinded study was performed on patients awaiting transhiatal esophagectomy. The patients were randomly allocated to receive sufentanil intrathecally or intravenously. Sufentanil consumption during the operation, pain score following the operation based on visual analog scale (VAS) and the morphine requirement for postoperative analgesia were assessed during the first 24 hours.


RESULTS
Fifty patients were divided in two groups. During the operation, the opioid requirement was higher in the IV group, whereas the morphine requirement during the first 24 hours after the operation was the same in both groups. The duration of effective postoperative analgesia was longer in patients in the IT group. VAS pain scores were significantly lower during the first 2 hours postoperatively in the IT group. The incidence of side effects such as nausea, vomiting, headache and respiratory depression was infrequent in both groups.


CONCLUSIONS
Preoperative IT sufentanil can be used as a booster to achieve rapid and effective analgesia not only during the operation but also during the immediate postoperative period.
Surgery Department, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
Ali Reza
AR
Bameshki
Mohammad-Reza
MR
Zanjankhah
Mehryar Taghavi
MT
Gilani
Patricia
P
Khashayar
D000368:Aged; D000700:Analgesics / Q000008:administration & dosage*; D016629:Esophagectomy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007278:Injections, Spinal; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D011292:Premedication; D017409:Sufentanil / Q000008:administration & dosage*
D000700:Analgesics; D017409:Sufentanil