MicroRNAs in mouse development and disease.
MicroRNAs, small non-coding RNAs which act as repressors of target genes, were discovered in 1993, and since then have been shown to play important roles in the development of numerous systems. Consistent with this role, they are also implicated in the pathogenesis of multiple diseases. Here we review the involvement of microRNAs in mouse development and disease, with particular reference to deafness as an example.
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Morag A
MA
Lewis
Karen P
KP
Steel
D000818:Animals; D003051:Cochlea / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D003638:Deafness / Q000235:genetics*; D004194:Disease / Q000235:genetics; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D016296:Mutagenesis
D035683:MicroRNAs; C541554:Mirn96 microRNA, mouse