[Relationship between activity of fibrinolysis, parameters of lipid spectrum and carbohydrate metabolism].
In this work analysis of results of a prospective populational cohort study "Stress and health in Russia" is presented. We included in the study inhabitants of Moscow randomly sampled from the population of men and women aged > or =55 years. Aim of the present work consisted in the study of relationship of activity of fibrinolysis and main parameters of the system of lipoproteines providing transport of lipids in blood serum and system controlling utilization of glucose by tissues. In dependence on fibrinolytic activity all examined persons were divided into 3 groups: with hypofibrinolysis (group 1, n=41.5%), with normofybrinolysis (group 2, n=41.9%), and hyperfibrinolysis (group 3, n=16.6%). In persons of group 1 low fibrinolytic activity and high level of fibrinogen were combined with atherogenic spectrum of blood serum lipids and elevated level of insulin at normal level of glucose. In patients of group 3 elevated fibrinolytic activity was combined with more favorable composition of blood lipids, lower levels of insulin and glucose and absence of obesity. At study of relation between fibrinoltic activity and a row of clinical states by the method of logistic regression a tendency to elevation of prevalence of myocardial infarction in persons with hypofibrinolysis was found while in persons with hyperfibrinolysis a significant lowering of prevalence of arterial hypertension, ischemic heart disease, and angina pectoris was observed.
Ratnikova
L A
LA
Metel'skaia
V A
VA
Shal'nova
S A
SA
Perova
N V
NV
Deev
A D
AD
Shkol'nikova
M A
MA
Shkol'nikov
V M
VM
D000368:Aged; D000787:Angina Pectoris / Q000097:blood / Q000453:epidemiology / Q000378:metabolism; D050197:Atherosclerosis; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D050260:Carbohydrate Metabolism; D016009:Chi-Square Distribution; D015331:Cohort Studies; D003627:Data Interpretation, Statistical; D005260:Female; D005340:Fibrinogen; D005342:Fibrinolysis; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000453:epidemiology / Q000378:metabolism; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000453:epidemiology / Q000378:metabolism; D017202:Myocardial Ischemia / Q000097:blood / Q000453:epidemiology / Q000378:metabolism; D056128:Obesity, Abdominal / Q000150:complications; D011446:Prospective Studies; D012737:Sex Factors
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D005340:Fibrinogen