Phytochemicals in hepatocellular cancer prevention.
Since the incidence of liver cancer is increasing in the world, it is valuable to develop an effective method for its prevention. Various phytochemicals have been shown to suppress liver carcinogenesis in experimental studies. Using these phytochemicals, a clinical trial was conducted. Combination of carotenoids and myo-inositol was found to prevent hepatocellular carcinoma development in patients with chronic viral hepatitis and cirrhosis.
Nishino
Hoyoku
H
Kyoto Prefectural University of Medicine and Ritsumeikan University, Kamigyo-ku, Kyoto, Japan. cha-nishino@nifty.com
D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000517:prevention & control*; D002338:Carotenoids / Q000627:therapeutic use*; D065366:Cryptoxanthins; D019587:Dietary Supplements; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006801:Humans; D007294:Inositol / Q000627:therapeutic use; D053208:Kaplan-Meier Estimate; D008103:Liver Cirrhosis / Q000150:complications*; D008113:Liver Neoplasms / Q000150:complications / Q000517:prevention & control*; D000077276:Lycopene; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D047368:Tumor Burden; D024341:Xanthophylls / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000008:administration & dosage; D019207:beta Carotene / Q000627:therapeutic use
D016588:Anticarcinogenic Agents; D065366:Cryptoxanthins; D024341:Xanthophylls; D019207:beta Carotene; D002338:Carotenoids; C041635:alpha-carotene; D007294:Inositol; D024502:alpha-Tocopherol; D000077276:Lycopene