Effects of apolipoprotein E-epsilon4 and -epsilon2 in amnestic mild cognitive impairment and dementia in Shanghai: SCOBHI-P.
OBJECTIVE
To determine apolipoprotein E (APOE)-epsilon4 and -epsilon2 frequencies and risk of mild cognitive impairment (MCI) and dementia in Shanghai, China.


METHODS
A total of 34 MCI and 34 dementia cases were recruited from an urban Memory Disorders Clinic and 32 controls were recruited from a residential community served by the clinic. Apolipoprotein E was genotyped using standard methods.


RESULTS
Among controls, frequencies were epsilon2, 0.11; epsilon3, 0.84; and epsilon4, 0.05; among MCI, 0.05, 0.77, and 0.18; and for dementia, 0.02, 0.84, and 0.15, respectively. In education-adjusted models, the odds ratio (OR) = 5.6 for dementia (95% CI = 1.09-29.3) and 4.7 for MCI (95% CI = 0.90-25.2) associated with any epsilon4 allele. The epsilon2 allele was inversely associated with dementia (OR = 0.12, 95% CI = 0.013-0.997) and MCI (OR = 0.38, 95% CI = 0.08-1.61).


CONCLUSIONS
APOE-epsilon4 increases and -epsilon2 decreases the risk of dementia vs normal cognition. Similar trends were observed for amnestic mild cognitive impairment (aMCI).
Borenstein
Amy R
AR
Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL 33612, USA. aborenst@health.usf.edu
Mortimer
James A
JA
Ding Ding
Schellenberg
Gerard D
GD
DeCarli
Charles
C
Qianhua Zhao
Copenhaver
Cathleen
C
Qihao Guo
Shugang Chu
Galasko
Douglas
D
Salmon
David P
DP
Qi Dai
Yougui Wu
Petersen
Ronald
R
Zhen Hong
D000368:Aged; D000647:Amnesia / Q000175:diagnosis / Q000235:genetics*; D053329:Apolipoprotein E2 / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics*; D002391:Catchment Area, Health; D002681:China / Q000453:epidemiology; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics*; D003704:Dementia / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D012720:Severity of Illness Index
D053329:Apolipoprotein E2; D053327:Apolipoprotein E4