The FoxO family in cardiac function and dysfunction.
The Forkhead family of transcription factors mediates many aspects of physiology, including stress response, metabolism, commitment to apoptosis, and development. The Forkhead box subfamily O (FoxO) proteins have garnered particular interest due to their involvement in the modulation of cardiovascular biology. In this review, we discuss the mechanisms of FoxO regulation and outcomes of FoxO signaling under normal and pathological cardiovascular contexts.
McAllister Heart Institute, University of North Carolina, Chapel Hill, NC 27599, USA. sarah.ronnebaum@unc.edu
Sarah M
SM
Ronnebaum
Cam
C
Patterson
D000375:Aging / Q000502:physiology; D000818:Animals; D001343:Autophagy / Q000502:physiology; D006332:Cardiomegaly / Q000473:pathology; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D006321:Heart / Q000254:growth & development / Q000502:physiology*; D006331:Heart Diseases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D051058:Oncogene Protein v-akt / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014158:Transcription, Genetic
D051858:Forkhead Transcription Factors; D051058:Oncogene Protein v-akt