Menthalactone, a new analgesic from Mentha cordifolia Opiz. Leaves.
* Author for correspondence and reprint requests Z. Naturforsch. 64c, 809-812 (2009); received May 7/July 23, 2009 Menthalactone, a new long-chain alkene with a bicyclic lactone moiety, was isolated as an analgesic constituent from the leaves of Mentha cordifolia Opiz. At a dosage of 100 mg/ kg mouse, it decreased the number of squirms induced by acetic acid by 67.3%. Statistical analysis using Kruskall Wallis one-way analysis of variance by ranks showed that menthalac-tone is different from the solvent control at alpha = 0.01 and approximates the analgesic activity of mefenamic acid at 0.001 level of significance.
Institute of Chemistry, Uiversity of the Philippines, Diliman, Quezon City 11010. Philippines. irene.villasenor@up.edu.ph
Irene M
IM
Villaseñor
Arlyn C
AC
Sanchez
D019342:Acetic Acid; D000475:Alkenes / Q000302:isolation & purification / Q000494:pharmacology; D000700:Analgesics / Q000302:isolation & purification* / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D008528:Mefenamic Acid / Q000494:pharmacology; D027541:Mentha / Q000737:chemistry*; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D018515:Plant Leaves / Q000737:chemistry*; D012997:Solvents
D000475:Alkenes; D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007783:Lactones; D012997:Solvents; D008528:Mefenamic Acid; D019342:Acetic Acid