Aging of the inceptive cellular population: the relationship between stem cells and aging.
The average life expectancy worldwide has about doubled and the global population has increased six fold over the past century. With improving health care in the developed world there is a proportional augmentation in the treatment necessary for elderly patients occasioning the call for increased research in the area of aging and age-related diseases. The manifestation of this research has been focalized on the causative cellular processes and molecular mechanisms involved. Here we will discuss the efforts of this research in the area of stem cells, delving into the regulatory mechanisms and how their de-regulation could be attributed to aging and age-related diseases.
Symonds
Catherine E
CE
Sbarro Institute for Cancer Research and Molecular Medicine, Center of Biotechnology, Temple University, Philadelphia, PA 19122, USA.
Galderisi
Umberto
U
Giordano
Antonio
A
D000375:Aging / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology*