Diagnostic utility of DTI in prostate cancer.
OBJECTIVE
The aim of this study was to compare the diffusion tensor parameters of prostate cancer, prostatitis and normal prostate tissue.


METHODS
A total of 25 patients with the suspicion of prostate cancer were included in the study. MRI was performed with 3 T system (Intera Achieva, Philips Medical Systems, The Netherlands). T2 TSE and DTI with ss-EPI were obtained in each subject. TRUS-guided prostate biopsy was performed after the MRI examination. Images were analyzed by two radiologists using a special software system. ROI's were drawn according to biopsy zones which are apex, midgland, base and central zone on each sides of the gland. FA and ADC values in areas of cancer, chronic prostatitis and normal prostate tissue were compared using Student's t-test.


RESULTS
Histopathological analysis revealed carcinoma in 68, chronic prostatitis in 67 and was reported as normal in 65 zones. The mean FA of cancerous tissue was significantly higher (p<0.01) than the FA of chronic prostatitis and normal gland. The mean ADC of cancerous tissue was found to be significantly lower (p<0.01), compared with non-cancerous tissue.


CONCLUSIONS
Decreased ADC and increased FA are compatible with the hypercellular nature of prostate tumors. These differences may increase the accuracy of MRI in the detection of carcinoma and to differentiate between cancer and prostatitis.
Yeditepe University Medical Faculty, Department of Radiology, İstanbul, Turkey. bengur0@yahoo.com
Bengi
B
Gürses
Neslihan
N
Tasdelen
Faruk
F
Yencilek
N Ozgür
NO
Kılıckesmez
Turgut
T
Alp
Zeynep
Z
Fırat
M Selami
MS
Albayrak
Aziz M
AM
Uluğ
A Nevzat
AN
Gürmen
D000368:Aged; D000369:Aged, 80 and over; D016880:Anisotropy; D001706:Biopsy; D003937:Diagnosis, Differential; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D011472:Prostatitis / Q000175:diagnosis* / Q000473:pathology; D012984:Software; D018084:Ultrasonography, Interventional