[A case successfully treated with total pelvic exenteration after preoperative chemotherapy FOLFOX4 plus bevacizumab for unresectable sigmoid colon cancer with extramural progression].
The patient was a 73-year-old woman. Her chief complaints were abdominal pain and lower abdominal distension. After some examinations, we diagnosed pelvic tumor, bladder cancer (adenocarcinoma) and sigmoid colon cancer. We performed a first operation, but the pelvic tumor was firmly fixed anterior to the sacrum and right common pelvic artery. We judged it unresectable and performed tumor biopsy and ileostomy. The pathological findings were very similar to sigmoid colon cancer, so we diagnosed that the pelvic tumor was sigmoid colon cancer with extramural progression. Later, the patient was treated with three courses of FOLFOX4 and three courses of bevacizumab+FOLFOX4. After this chemotherapy, the pelvic tumor was reduced significantly, we considered resection possible and performed pelvic exenteration. She has had no recurrence for 6 months after second operation. This treatment appeared to be effective for unresectable primary colon cancer.
Dept. of Surgery, Machida Municipal Hospital.
Hideharu
H
Yasue
Nobuyoshi
N
Hanyu
Teruyuki
T
Usuba
Mitsubumi
M
Abe
D000368:Aged; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000276:immunology / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D000068258:Bevacizumab; D001706:Biopsy; D003131:Combined Modality Therapy; D018450:Disease Progression; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000627:therapeutic use; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000627:therapeutic use; D010385:Pelvic Exenteration; D012074:Remission Induction; D012811:Sigmoid Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed
D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D009944:Organoplatinum Compounds; D000068258:Bevacizumab; D002955:Leucovorin; D005472:Fluorouracil