Mechanism of action of a desensitizing fluoride toothpaste delivering calcium and phosphate ingredients in the treatment of dental hypersensitivity. Part III: Prevention of dye penetration through dentin vs a calcium- and phosphate-free control.
It is generally accepted that the pain of dental hypersensitivity resulting from gum recession is from the movement of fluid within the exposed tubules of dentin, causing changes in pressure on the nerve within the pulpal cavity. One method of treating hypersensitivity is to occlude the tubules, preventing fluid movement. This article discusses the use of a dye penetration technique, which establishes this mechanism of action for a desensitizing fluoride toothpaste containing calcium and phosphate. Two groups of intact teeth were perfectly sealed with enamel paint. Windows 100-micro to 200-micro deep were opened on opposite sides of each tooth at the dentin-enamel junction and briefly etched using 20% polyacrylic acid. One batch of teeth was treated eight times for 30 mins each with a 1:3 slurry of the desensitizing toothpaste and another set with a similar slurry prepared from a calcium- and phosphate-free control. A 0.85% aqueous solution of acid red fuchsin dye was applied to each window and allowed to dry. After a brief rinse, the teeth were sectioned across the windows. Almost no dye penetration was seen in teeth treated with the desensitizing toothpaste; however, extensive penetration through the dentin was visible in the control-treated teeth. The differences in dye penetration for the two sets of teeth were significant by both subjective (P < .001) and objective (P < .01) measures. Tubule occlusion because of calcium and phosphate ions from the desensitizing toothpaste accounts for its tooth desensitizing efficacy.
R&D for Hire, LLC, East Brunswick, New Jersey, USA.
Anthony E
AE
Winston
Andrew J
AJ
Charig
Stephen
S
Thong
D002133:Calcium Sulfate / Q000008:administration & dosage / Q000494:pharmacology; D002327:Cariostatic Agents / Q000008:administration & dosage; D004396:Coloring Agents; D057133:Dentin Desensitizing Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003806:Dentin Permeability / Q000187:drug effects*; D003807:Dentin Sensitivity / Q000209:etiology / Q000517:prevention & control*; D019234:Dentinal Fluid / Q000187:drug effects*; D005459:Fluorides / Q000008:administration & dosage; D005889:Gingival Recession / Q000150:complications; D006801:Humans; D006861:Hydrogen Peroxide; D009566:Nitrates / Q000494:pharmacology; D010710:Phosphates / Q000008:administration & dosage / Q000494:pharmacology; D017680:Potassium Compounds / Q000008:administration & dosage / Q000494:pharmacology; D012394:Rosaniline Dyes; D017693:Sodium Bicarbonate / Q000737:chemistry / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000737:chemistry / Q000627:therapeutic use; D009435:Synaptic Transmission / Q000187:drug effects; D014100:Toothpastes / Q000737:chemistry* / Q000627:therapeutic use
D002327:Cariostatic Agents; D004396:Coloring Agents; D057133:Dentin Desensitizing Agents; D009566:Nitrates; D010710:Phosphates; D017680:Potassium Compounds; D012394:Rosaniline Dyes; D014100:Toothpastes; C546054:sodium bicarbonate-based toothpaste; D017693:Sodium Bicarbonate; D012969:Sodium Fluoride; C013216:potassium phosphate; D006861:Hydrogen Peroxide; D005459:Fluorides; C023844:potassium nitrate; D002133:Calcium Sulfate