What is the best method for measuring renal function in adults and children with cystic fibrosis?
To measure the glomerular filtration rate (GFR) in adults and children with cystic fibrosis (CF) using a radio-isotope technique as the gold standard and to compare this to serum creatinine based equations, serum cystatin C levels and tobramycin clearance, and to determine which method correlates most closely with measured GFR in this population.
Soulsby
Natalie
N
Sansom Institute, University of South Australia, Frome Road, Adelaide, SA 5001, Australia. Natalie.soulsby@unisa.edu.au
Greville
Hugh
H
Coulthard
Kingsley
K
Doecke
Chris
C
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000097:blood; D003550:Cystic Fibrosis / Q000150:complications / Q000503:physiopathology*; D003627:Data Interpretation, Statistical; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007239:Infections / Q000150:complications / Q000188:drug therapy; D007275:Injections, Intravenous; D007677:Kidney Function Tests / Q000592:standards*; D008171:Lung Diseases / Q000150:complications / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D012680:Sensitivity and Specificity; D016284:Technetium Tc 99m Pentetate / Q000493:pharmacokinetics; D014031:Tobramycin / Q000008:administration & dosage / Q000493:pharmacokinetics; D055815:Young Adult
D000900:Anti-Bacterial Agents; D055316:Cystatin C; D019275:Radiopharmaceuticals; D003404:Creatinine; D016284:Technetium Tc 99m Pentetate; D014031:Tobramycin