Radiotherapy for canine chronic superficial keratitis using soft X-rays (15 kV).
OBJECTIVE
To evaluate the effect of soft X-ray therapy in the treatment of refractory chronic superficial keratitis (CSK).


METHODS
Thirteen dogs with severe CSK, that had been refractory to prior medical and/or surgical therapy were treated with soft X-ray therapy.


METHODS
Both corneas of each dog were irradiated with soft X-rays (15 kV), to a total dose of 30 Gy, administered as two fractions over 48-96 h. Treatment was carried out under deep sedation in all dogs. Three dogs were treated by superficial lamellar keratectomy 48 h prior to radiotherapy. Changes in the extent of corneal pigmentation, pigment density and corneal vascularization were documented using a semi-quantitative grading scheme, schematic drawings and clinical photographs.


RESULTS
Only minor, transient adverse effects of treatment, such as photophobia, epiphora and blepharitis were noted. Overall the effect of soft X-rays on the course of the keratitis was superior when compared to the effect of Sr-90 irradiation that had been determined in a previous study.


CONCLUSIONS
Soft X-ray irradiation combined with keratectomy is a safe and effective new treatment option for severe and advanced CSK with significant visual impairment due to corneal pathology.
Allgoewer
Ingrid
I
Animal Eye Practice, Lindenthaler Allee 9, 14163 Berlin, Germany. ia@tieraugen.com
Hoecht
Stefan
S
D000818:Animals; D001764:Blepharospasm / Q000209:etiology / Q000662:veterinary; D003315:Cornea / Q000528:radiation effects; D004283:Dog Diseases / Q000532:radiotherapy*; D004285:Dogs; D007634:Keratitis / Q000532:radiotherapy / Q000662:veterinary*; D007766:Lacrimal Apparatus Diseases / Q000209:etiology / Q000662:veterinary; D020795:Photophobia / Q000209:etiology / Q000662:veterinary; D011446:Prospective Studies; D011829:Radiation Dosage