Whither the bone marrow transplant?
Bone marrow transplantation (BMT) has become an accepted and important medical intervention which has become a routine part of medical practice. Its utility has, however, been questioned recently in a number of diseases in which its role has been clearly established on the basis that there are better non-transplant therapeutic options. The suspicion that these moves to eradicate BMT as an option may not stem from purely scientific reasons has prompted the preparation of these personal reflections. I will focus this discussion only on two diseases in which BMT has been shown to be useful: chronic myelogenous leukemia (CML) and multiple myeloma (MM).
Centro de Hematología y Medicina Interna de Puebla, PUE, Mexico. gruiz1@clinicaruiz.com
Guillermo J
GJ
Ruiz-Argüelles
D000970:Antineoplastic Agents / Q000191:economics / Q000627:therapeutic use; D001549:Benzamides; D016026:Bone Marrow Transplantation / Q000191:economics / Q000706:statistics & numerical data / Q000639:trends*; D019049:Developed Countries / Q000191:economics; D003906:Developing Countries / Q000191:economics; D016527:Drug Costs; D004363:Drug Utilization / Q000191:economics; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000601:surgery; D008558:Melphalan / Q000008:administration & dosage / Q000191:economics; D008800:Mexico; D009101:Multiple Myeloma / Q000601:surgery; D010879:Piperazines / Q000191:economics / Q000627:therapeutic use; D047428:Protein Kinase Inhibitors / Q000191:economics / Q000627:therapeutic use; D011743:Pyrimidines / Q000191:economics / Q000627:therapeutic use; D013030:Spain; D019172:Transplantation Conditioning / Q000191:economics; D014182:Transplantation, Autologous / Q000191:economics; D014184:Transplantation, Homologous / Q000191:economics; D016896:Treatment Outcome; D014481:United States
D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D008558:Melphalan