Synthesis of PVP-coated ultra-small Fe3O4 nanoparticles as a MRI contrast agent.
Ultra-small Fe(3)O(4) nanoparticles were prepared by using the coprecipitation method, in which the polyvinylpyrrolidone (PVP) serves as a stabilizer. The nanoparticles were characterized by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), infra spectrum (IR), X-ray photoelectron spectroscopy (XPS) and in vivo magnetic resonance imaging (MRI) test. The results showed that the particles' size was determined by the dripping rate and that PVP molecules played the role of preventing the aggregation and restricting the size of Fe(3)O(4) nanoparticles. The Fe(3)O(4) nanoparticles with diameter from 6.5 to 1.9 nm obviously exhibited negative contrast enhancement and concentrated at the target area guided by a permanent magnet.
Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Sciences, Shenyang, People's sRepublic of China. yzhang7704@imr.ac.cn
Ying
Y
Zhang
Jing-Ying
JY
Liu
Song
S
Ma
Ya-Jing
YJ
Zhang
Xiang
X
Zhao
Xiang-Dong
XD
Zhang
Zhi-Dong
ZD
Zhang
D000818:Animals; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000737:chemistry; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry; D005079:Excipients / Q000737:chemistry / Q000494:pharmacology; D005290:Ferric Compounds / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods; D008280:Magnetics; D008422:Materials Testing; D053768:Metal Nanoparticles / Q000737:chemistry; D051379:Mice; D046529:Microscopy, Electron, Transmission; D010316:Particle Size; D056951:Photoelectron Spectroscopy; D011205:Povidone / Q000737:chemistry* / Q000494:pharmacology; D014961:X-Ray Diffraction
D020099:Coated Materials, Biocompatible; D003287:Contrast Media; D005079:Excipients; D005290:Ferric Compounds; C000499:ferric oxide; D011205:Povidone