Secondary metabolites of Volvariella bombycina and their inhibitory effects on melanogenesis.
Four compounds were isolated from the broth culture of Volvariella bombycina and they were identified as ergosta-4,6,8(14),22-tetraene-3-one (1), ergosterol peroxide (2), indole-3-carboxaldehyde (3) and indazole (4) by interpretation of spectroscopic data. Among them, compound 2 exhibited melanogenesis inhibitory effect in cultured B16 mouse melanoma cells.
Chemical Biology Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Korea.
Guang-Hua
GH
Xu
Soo-Jin
SJ
Choo
Young-Hee
YH
Kim
In-Ja
IJ
Ryoo
Soon-Ja
SJ
Seok
Jong-Seog
JS
Ahn
Ick-Dong
ID
Yoo
D000818:Animals; D001685:Biological Factors / Q000378:metabolism* / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004875:Ergosterol / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology; D007191:Indazoles / Q000378:metabolism / Q000494:pharmacology*; D008543:Melanins / Q000096:biosynthesis; D008546:Melanoma, Experimental / Q000378:metabolism*; D008660:Metabolism / Q000187:drug effects*; D051379:Mice; D055367:Volvariella / Q000737:chemistry / Q000378:metabolism*
D001685:Biological Factors; D007191:Indazoles; D008543:Melanins; C036071:ergosterol-5,8-peroxide; D004875:Ergosterol