[Mechanism of sex differences and the clinical significance of PPARgamma targeted drugs].
Peroxisome proliferator-activated receptor (PPAR) gamma is the nuclear receptor which mainly distributes in adipose tissues. It plays a key role in the differentiation of adipocytes. In Japan, pioglitazone hydrochloride (Actos) is the only drug which targets PPARgamma among antidiabetic drugs. It had been reported that there are sex differences in pharmacological and side effects of pioglitazone hydrochloride. This is a brief overview on the mechanism of sex differences of this drug, especially focusing on the role of sex hormones on PPARgamma expression. Moreover, we also considered about the effects of such differences on clinical applications from our research of prescribing data in 20 hospitals and also the result of PRospective ACTos practICAL experience (PRACTICAL).
Ueno
Koichi
K
Department of Geriatric Pharmacology and Therapeutics, Graduate School of Pharmaceutical Sciences, Chiba University.
Sugai
Hana
H
Sato
Hiromi
H
D005260:Female; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D047495:PPAR gamma / Q000502:physiology*; D000077205:Pioglitazone; D012737:Sex Factors; D045162:Thiazolidinediones / Q000494:pharmacology*
D012739:Gonadal Steroid Hormones; D007004:Hypoglycemic Agents; D047495:PPAR gamma; D045162:Thiazolidinediones; D000077205:Pioglitazone