Single nucleotide polymorphism of the KIBRA gene in recurrent depressive disorders.
OBJECTIVE
Depression is a disease of multifactor background. Episodic memory dysfunction is one of depression characterising disturbances, which may lead to its onset and development. Memory processes are controlled by a number of extra- and intracellular mechanisms. KIBRA, a newly discovered protein, belonging to signal transduction proteins, participates in the control of episodic memory. The presented study was designed to assess correlation between single nucleotide polymorphism (SNP) T/C (rs17070145) of the KIBRA gene and the risk of recurrent depressive disorder (DD).


METHODS
The study was carried out in a group of 181 patients with recurrent DD and 149 healthy control subjects. Genotyping was conducted by polymerase chain reaction (PCR)/restriction fragment length polymorphism (RLFP) method.


RESULTS
TThe obtained results have revealed no significant correlation between the studied polymorphism and recurrent DD. Obtained value of the disease odds ratio (ORdis) suggests that presence of T/T homozygote decreases risk of development of recurrent DD, but the result was not statistically significant.


CONCLUSIONS
Following the results, it may be concluded that the studied polymorphism does not influence either the onset mechanism or the course of recurrent DD. Even if T/C polymorphism of the KIBRA gene induces memory disturbances, they may be unspecific and unselective for recurrent DD. Further studies on the genes, which control characteristic processes of DD and influence their course, are demanded and mostly justified.
Department of Adult Psychiatry, Medical University of Lodz, Poland.
Piotr
P
Galecki
Janusz
J
Szemraj
Antoni
A
Florkowski
Monika
M
Talarowska
Malgorzata
M
Bienkiewicz
Elzbieta
E
Galecka
Andrzej
A
Lewinski
D017668:Age of Onset; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008569:Memory Disorders / Q000235:genetics; D010750:Phosphoproteins; D020641:Polymorphism, Single Nucleotide; D011506:Proteins / Q000235:genetics*; D012008:Recurrence
D047908:Intracellular Signaling Peptides and Proteins; D010750:Phosphoproteins; D011506:Proteins; C513637:WWC1 protein, human