Isolation of a new glycoside from starfish, Asterias amurensis Lutken, and its stimulation activity on the proliferation of the UMR106 cell.
A new glycoside compound (1) was isolated from the starfish Asteria amurensis Lutken. The structure for compound 1 was identified as 1-O-{beta-D-quinovopyranosyl-(1-2)-beta-D-fucopyranosyl-(1-4)-[beta-D-fucopyranosyl(1-2)] beta-D-quinovopyranosyl}-butanol by extensive NMR experiments as well as chemical evidence. The effects of compound 1 on UMR106 cell proliferation were screened by MTT assay. The results indicate that compound 1 (0.01-100 microM) significantly promotes osteoblastic proliferation.
Liu
Hong-Wei
HW
Key Laboratory of Systematic Mycology and Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, PR China. liuhongwei60@yahoo.com.cn
Li
Jian-Kuan
JK
Zhang
Da-Wei
DW
Zhang
Jing-Chao
JC
Zhang
Xue
X
Song
Xiao-Hong
XH
Xia
Ying
Y
Wang
Nai-Li
NL
Yao
Xin-Sheng
XS
Cai
Guo-Ping
GP
D000818:Animals; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D010006:Osteoblasts / Q000187:drug effects*; D013215:Starfish / Q000737:chemistry*
C549148:1-O-(beta-D-quinovopyranosyl-(1-2)-beta-D-fucopyranosyl-(1-4)-(beta-D-fucopyranosyl(1-2))beta-D-quinovopyranosyl)butanol; D006027:Glycosides