Failure of the GnRH antagonist ganirelix to block the positive feedback effect of exogenous estrogen in normal women.
This study investigated whether the GnRH antagonist ganirelix is able to block the positive-feedback effect of E2 in normal women. Ganirelix was unable to block the positive-feedback effect, suggesting that the clinical efficacy of GnRH antagonists in IVF cycles is determined by the hyperstimulation process.
Messinis
Ioannis E
IE
Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece. Electronic address: messinis@med.uth.gr.
Vanakara
Polyxeni
P
Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece.
Zavos
Apostolos
A
Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece.
Verikouki
Christina
C
Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece.
Georgoulias
Panagiotis
P
Department of Nuclear Medicine, Medical School, University of Thessalia, Larissa, Greece.
Dafopoulos
Konstantinos
K
Department of Obstetrics and Gynecology, Medical School, University of Thessalia, Larissa, Greece.
D000279:Administration, Cutaneous; D000328:Adult; D004958:Estradiol / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D025461:Feedback, Physiological / Q000187:drug effects*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors* / Q000494:pharmacology / Q000627:therapeutic use; D006262:Health; D006727:Hormone Antagonists / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood / Q000187:drug effects; D010062:Ovulation Induction; D011374:Progesterone / Q000097:blood; D017211:Treatment Failure
D006727:Hormone Antagonists; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol; C061018:ganirelix