Tetrapeptides possessing a unique skeleton, JBIR-34 and JBIR-35, isolated from a sponge-derived actinomycete, Streptomyces sp. Sp080513GE-23.
Two new modified indole-containing peptides, JBIR-34 (1) and JBIR-35 (2), were isolated from the fermentation broth of a sponge-derived actinomycete identified by phylogenetic methods as a Streptomyces sp. (strain Sp080513GE-23). The planar structures of 1 and 2 were assigned on the basis of 1D and 2D NMR spectroscopy and MS analyses. Further, the absolute configurations of the amino acid residues were determined using Marfey's method.
Biomedicinal Information Research Center, Japan Biological Informatics Consortium, 2-4-7 Aomi, Koto-ku, Tokyo 135-0064, Japan.
Keiichiro
K
Motohashi
Motoki
M
Takagi
Kazuo
K
Shin-Ya
D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000032:analysis; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010851:Picrates / Q000494:pharmacology; D011161:Porifera / Q000382:microbiology; D013302:Streptomyces / Q000737:chemistry*
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D007211:Indoles; C548191:JBIR-34; C548192:JBIR-35; D009842:Oligopeptides; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl