The effect of platelet-rich plasma on early and late bone healing using a mixture of particulate autogenous cancellous bone and Bio-Oss: an experimental study in goats.
Platelet-rich plasma (PRP), containing various growth factors, may speed up wound and bone healing. Using osteoconductive alloplastic materials in reconstructive surgery, the amount of autogenous bone needed can be reduced. The purpose of this experiment was to study the effect of PRP on a mixture of autogenous bone and deproteinized bovine bone mineral (Bio-Oss) particles in goats. Four, round, critical size defects were made in the foreheads of 20 goats. In all goats the defects were filled with a mixture of autogenous particulate cancellous bone and (Bio-Oss) particles, in which 1 ml of PRP was added in two of the four defects. The goats were allocated to four subgroups each containing five goats, which were killed after 1, 2, 6 and 12 weeks. The results of the histological and histomorphometric examination showed that early and late bone healing were not enhanced when PRP was used.
Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. r.mooren@chello.nl
R E C M
RE
Mooren
A C A
AC
Dankers
M A W
MA
Merkx
E M
EM
Bronkhorst
J A
JA
Jansen
P J W
PJ
Stoelinga
D000818:Animals; D001847:Bone Diseases / Q000473:pathology / Q000601:surgery; D001857:Bone Matrix / Q000637:transplantation*; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000473:pathology / Q000502:physiology*; D002417:Cattle; D005260:Female; D005546:Forehead / Q000601:surgery; D005624:Frontal Bone / Q000473:pathology / Q000601:surgery; D015726:Giant Cells / Q000473:pathology; D006041:Goats; D007091:Image Processing, Computer-Assisted; D008903:Minerals / Q000627:therapeutic use*; D010012:Osteogenesis / Q000502:physiology; D053657:Platelet-Rich Plasma / Q000502:physiology*; D013997:Time Factors; D014945:Wound Healing / Q000502:physiology
C077540:Bio-Oss; D018786:Bone Substitutes; D008903:Minerals