Widespread pulmonary granulomatosis following long time intravenous drug abuse--a case report.
Foreign body granulomas in the lungs following acute singular or long time intravenous drug abuse are frequent findings during microscopic investigation of the lungs. Most cases present single granulomas. Cases with multiple foreign body granulomas, already palpable during autopsy and leading to pulmonary granulomatosis with multiple granulomas are less frequent. We report the case of a 32-year old man, dying suddenly and unexpectedly after a well-known history of drug abuse for more than a decade. The granulomas are caused by foreign particle embolization immediately after intravenous injection of not only the drug itself but also of adulterants, e.g. cotton fibers, potato starch or microcrystalline cellulose. At the end, a reduction in the size of the pulmonary bed had occurred followed by pulmonary hypertension. For the first time, lung dust in such a case was characterised by energy dispersive X-ray (EDX).
Institute of Forensic Medicine, Justus-Liebig-University of Giessen, Giessen, Germany. reinhard.dettmeyer@forens.med.uni-giessen.de
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Dettmeyer
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MA
Verhoff
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B
Brückel
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D
Walter
D000328:Adult; D049429:Forensic Pathology; D053593:Forensic Toxicology; D015743:Giant Cells, Foreign-Body / Q000473:pathology; D015745:Granuloma, Foreign-Body / Q000139:chemically induced / Q000473:pathology*; D015769:Granuloma, Respiratory Tract / Q000139:chemically induced / Q000473:pathology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000209:etiology; D013287:Illicit Drugs / Q000009:adverse effects / Q000138:chemical synthesis; D008168:Lung / Q000473:pathology; D008297:Male; D046529:Microscopy, Electron, Transmission; D013052:Spectrometry, X-Ray Emission; D015819:Substance Abuse, Intravenous / Q000150:complications*; D013627:Talc
D013287:Illicit Drugs; D013627:Talc