Eosinophilic airway inflammation in a cynomolgus monkey.
The present article describes an occurrence of eosinophilic airway inflammation of a 4-year-old female cynomolgus monkey in a vehicle control group of a routine toxicology study. Histologically, the airway lesion was characterized by prominent eosinophilic infiltrates, accompanied by mast cells, lymphocytes, and plasmacytes. The eosinophilic infiltrates were distributed throughout the airway: from trachea through respiratory bronchioles in the lung. The morphological feature of the lesion was indicative of an allergic airway disorder that can occur in humans with asthma. The present case is remarkable in that there is a paucity of reports on naturally occurring allergic airway disorders in nonhuman primates.
Drug Safety Research and Development, Pfizer Global Research and Development, Groton Laboratories, Groton, CT 06340, USA. norimitsu.shirai@pfizer.com
N
N
Shirai
F J
FJ
Geoly
D000818:Animals; D004802:Eosinophilia / Q000276:immunology / Q000662:veterinary*; D005260:Female; D006651:Histocytochemistry / Q000662:veterinary; D007249:Inflammation / Q000276:immunology / Q000662:veterinary*; D008252:Macaca fascicularis; D008992:Monkey Diseases / Q000276:immunology*; D012140:Respiratory Tract Diseases / Q000276:immunology / Q000662:veterinary*