Synthesis and anti-tuberculosis activity of new hetero(Mn, Co, Ni)trinuclear iron(III) furoates.
New hetero(micro(3)-oxo)trinuclear iron(III) furoates with the general formulas [Fe(2)MO(alpha-Fur)(6)(L)(H(2)O)(2)], where L = THF (1-3), DMF (4-5), M = Mn(2+) (1, 4), Co(2+) (2, 5), Ni(2+) (3, 6) and [Fe(2)MO(alpha-Fur)(6)(3Cl-Py)(3)], where M = Mn(2+) (7), Co(2+) (8), Ni(2+) (9); have been synthesised and investigated by Mössbauer and IR spectroscopies. The X-ray crystal structure has been determined for the 4 and 8 complexes, indicating that they are related to the monoclinic crystal system (P2(1)/n) and have a structure typical of mu(3)-O-bridged trinuclear iron (III) compounds. The (57)Fe Mössbauer spectra of microcrystalline samples of the compounds indicate the presence of high-spin iron (III) (S = 5/2) with a near symmetrical environments. The iron(III)-cobalt(II) containing compounds 2, 5 and 8 displayed MIC values between 0.83 / 4.00 microg/mL.
Melnic
Silvia
S
Institute of Chemistry of ASM, Academiei str. 3, Chisinau 2028, Republic of Moldova.
Prodius
Denis
D
Stoeckli-Evans
Helene
H
Shova
Sergiu
S
Turta
Constantin
C
D000818:Animals; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D003035:Cobalt / Q000737:chemistry; D018360:Crystallography, X-Ray; D005290:Ferric Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008345:Manganese / Q000737:chemistry; D008958:Models, Molecular; D009532:Nickel / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D015204:Spectroscopy, Mossbauer; D014709:Vero Cells
D000995:Antitubercular Agents; D005290:Ferric Compounds; D003035:Cobalt; D008345:Manganese; D009532:Nickel