A comparison of the antibody responses between specific pathogen-free and commercial layers immunized with an influenza vaccine prepared from inactivated non-pathogenic H5N1 virus by single shot.
It is known that antibody responses in chickens against invading organisms or antigens are considerably different among different lines. Thus, an avian influenza vaccine was prepared from inactivated whole particles of the virus of non-pathogenic strain A/duck/Hokkaido/Vac-1/04 (H5N1) using an oil adjuvant containing anhydromannitol-octadecenoate-ether and injected intramuscularly into each ten 10-week-old specific pathogen-free (SPF) white leghorn chickens and commercial layers of Julia and Boris-Brown to obtain comparative data for antibody responses until 6 weeks after vaccination. Despite significant partial differences of antibody titer between the chicken lines, this study clearly showed that the vaccine induced good and sufficient antibody response in both SPF chickens and commercial layers.
Avian Biologics Department, Kyoto Biken Laboratories, Inc., Japan.
Takashi
T
Sasaki
Norihide
N
Kokumai
Toshiaki
T
Ohgitani
Takashi
T
Imamura
Akira
A
Sawata
Zhifeng
Z
Lin
Yoshihiro
Y
Sakoda
Hiroshi
H
Kida
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000917:Antibody Formation; D002645:Chickens / Q000097:blood / Q000145:classification / Q000276:immunology* / Q000821:virology*; D004196:Disease Outbreaks / Q000517:prevention & control; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D005585:Influenza in Birds / Q000276:immunology*; D013047:Specific Pathogen-Free Organisms / Q000276:immunology*; D015164:Vaccines, Inactivated / Q000627:therapeutic use*; D014765:Viral Vaccines / Q000627:therapeutic use*
D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines