Regio- and stereoselective synthesis of novel dispiropyrrolidine bisoxindole derivatives via multicomponent reactions.
A convenient and efficient method for the synthesis of novel dispiropyrrolidine bisoxindole derivatives by 1,3-dipolar cycloaddition reaction of azomethine ylides has been developed. The synthesis was achieved by using a one-pot multicomponent procedure. The features of this procedure were characterized by the following: mild reaction conditions, high yields, high regio- and stereoselectivity, one-pot procedure, and operational simplicity.
Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P R China.
Hai
H
Liu
Guolan
G
Dou
Daqing
D
Shi
D007211:Indoles / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D011759:Pyrrolidines / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013237:Stereoisomerism
D007211:Indoles; D011759:Pyrrolidines; C032519:pyrrolidine