Kisspeptin: a novel role in the regulation of reproductive function.
Kisspeptin appears to have a pivotal role in the regulation of reproductive function and may have a therapeutic role in the treatment of disorders of reproduction. In this review we summarise the evidence regarding kisspeptin and its function in the hypothalamic pituitary gonadal axis and also examine future therapeutic applications.
Department of Investigative Medicine, Imperial College London, Hammersmith Hospital, London, UK.
Gurjinder K
GK
Nijher
Waljit S
WS
Dhillo
Stephen R
SR
Bloom
D000818:Animals; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D059648:Kisspeptins; D010913:Pituitary-Adrenal System / Q000378:metabolism; D011627:Puberty / Q000502:physiology; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects / Q000378:metabolism; D000074502:Receptors, Kisspeptin-1; D012098:Reproduction / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000378:metabolism*
C106628:KISS1 protein, human; C118688:KISS1R protein, human; D059648:Kisspeptins; D043562:Receptors, G-Protein-Coupled; D000074502:Receptors, Kisspeptin-1; D025521:Tumor Suppressor Proteins