Metabolomic systems biology of trypanosomes.
Metabolomics analysis, which aims at the systematic identification and quantification of all metabolites in biological systems, is emerging as a powerful new tool to identify biomarkers of disease, report on cellular responses to environmental perturbation, and to identify the targets of drugs. Here we discuss recent developments in metabolomic analysis, from the perspective of trypanosome research, highlighting remaining challenges and the most promising areas for future research.
Barrett
Michael P
MP
Faculty of Biomedical and Life Sciences and Wellcome Trust Centre of Molecular Parasitology, University of Glasgow, Glasgow Biomedical Research Centre, Glasgow G12 8TA, United Kingdom. m.barrett@bio.gla.ac.uk
Bakker
Barbara M
BM
Breitling
Rainer
R
D018503:Genome, Protozoan; D055442:Metabolome; D055432:Metabolomics / Q000379:methods; D008957:Models, Genetic; D014352:Trypanosomiasis / Q000235:genetics / Q000378:metabolism*