[P53 abnormality and clinical prognosis of leukemia patients with complex chromosomal abnormalities].
OBJECTIVE
To investigate the p53 deletion in leukemia patients with complex chromosomal abnormalities (CCA) and the clinical significance.


METHODS
The p53 deletion status of 38 leukemia cases with CCA and 24 cases without CCA were analyzed by interphase fluorescence in situ hybridization (I-FISH).


RESULTS
The frequency of p53 deletion in the 38 patients with CCA (44.74%) was significantly higher than that in the 24 cases without CCA (4.16%) (P<0.01). The rate of complete remission in 13 cases of acute leukemia with CCA was 15.4%, with median survival time (MST) of 105 days.


CONCLUSIONS
I-FISH is a rapid, accurate and sensitive technique for detection of p53 deletion, patients with CCA have a higher p53 deletion and a lower complete remission rate and MST.
Zou
Zhaoling
Z
Department of Hematology, the Third Affiliated Hospital of Soochou University, the First People's Hospital of Changzhou, Changzhou, Jiangsu, 213003 P.R. China.
Cao
Xiangshan
X
Wang
Zhilin
Z
D000293:Adolescent; D000328:Adult; D000368:Aged; D001854:Bone Marrow Cells / Q000166:cytology; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005260:Female; D017353:Gene Deletion; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007938:Leukemia / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism; D055815:Young Adult
D016159:Tumor Suppressor Protein p53