The hare and the tortoise: one small step for four SNPs, one giant leap for SNP-kind.
A recently published study has used next-gen sequencing technology to resequence two Y chromosomes separated by 13 generations and discovered four single-base differences in approximately 10Mb DNA, suggesting that the Y chromosome euchromatin accumulates around one mutation per generation. Y-SNPs therefore now offer the best resolution of Y haplotypes and promise to distinguish almost every Y chromosome. This work illustrates the promise of current sequencing technology for forensically relevant applications.
The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambs CB10 1SA, UK.
Yali
Y
Xue
Chris
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Tyler-Smith
D000818:Animals; D004247:DNA / Q000235:genetics; D053803:Forensic Genetics / Q000379:methods; D034621:Hares / Q000235:genetics*; D008297:Male; D009154:Mutation; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014426:Turtles / Q000235:genetics*; D014998:Y Chromosome / Q000235:genetics
D004247:DNA