Component analysis and free radical-scavenging potential of Panax notoginseng and Carthamus tinctorius extracts.
Panax notoginseng and Carthamus tinctorius are known as traditional medicinal plants, and they also have edible values. To better understand their pharmacological mechanism, the present study assessed the in vitro antioxidant activities of extracts of P. notoginseng (EPN) and C. tinctorius (ECT). In addition, the main components of EPN and ECT were determined by HPLC. The results show that EPN mainly contained saponins, which were effective in scavenging (.)OH and O(.)(2-), while showing a low activity in the DPPH(.) assay. Flavonoids were the main components of ECT and were active in scavenging all three radicals in a dose-dependent manner. In brief, the antioxidant properties of EPN and ECT are distinct and might be complementary, their combined use tending to be more effective in scavenging (.)OH (P<0.05 vs. EPN or ECT).
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
Shu-Yan
SY
Han
Hai-Xia
HX
Li
Chang-Cai
CC
Bai
Li
L
Wang
Peng-Fei
PF
Tu
D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D031187:Carthamus tinctorius / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D016166:Free Radical Scavengers / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D017665:Hydroxyl Radical / Q000037:antagonists & inhibitors; D008968:Molecular Conformation; D053723:Panax notoginseng / Q000737:chemistry*; D010936:Plant Extracts / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000037:antagonists & inhibitors; D013045:Species Specificity; D013237:Stereoisomerism
D000975:Antioxidants; D016166:Free Radical Scavengers; D010936:Plant Extracts; D017382:Reactive Oxygen Species; D017665:Hydroxyl Radical