title: Castleman's disease: a study of a rare lymphoproliferative disorder in a university hospital.
abstract: Castleman's disease (CD) is a group of rare lymphoproliferative disorders sharing characteristic clinical and histological features, and usually accompanied by a marked systemic inflammatory response. Two histological patterns of lymph nodes were described: the hyaline-vascular and plasma-cell types. The former is more common (80-90%) and tends to be localized. The plasma cell type is more aggressive and usually multicentric. It is interesting that the inflammatory manifestations seem to be related to a lymph node lesion, because the systemic symptoms and inflammatory activity can return to normal after surgical excision or successful medical treatment of the disease. We report here our 15-year experience with this rare disease in King Fahd Hospital of the University, Al-Khobar, Saudi Arabia, focusing on the clinical features, therapy, and patients'outcome.
authors.affiliation: King Fahd University Hospital, Al-Khobar, Saudi Arabia.
authors.forename: A M
authors.initials: AM
authors.lastname: Al-Amri
authors.forename: I S
authors.initials: IS
authors.lastname: Abdul-Rahman
authors.forename: K Q
authors.initials: KQ
authors.lastname: Ghallab
mesh_terms: D000293:Adolescent; D000328:Adult; D005871:Castleman Disease / Q000473:pathology* / Q000601:surgery; D005260:Female; D006785:Hospitals, University; D006801:Humans; D006818:Hyalin / Q000378:metabolism; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010950:Plasma Cells / Q000473:pathology*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D055815:Young Adult