title: [Non-traumatic rhabdomyolysis in medical practice].
abstract: Rhabdomyolysis, meaning "disintegration of striated muscle", is a potentially life-threatening syndrome resulting from release of muscular cell constituents into the circulation. The aim of this study is to determine frequence and causes of rhabomyolysis in internal medicine practice, as well as diagnostic and therapeutic discussions, based on a retrospective study in patients addressed to a medical clinic of an universitary emergency hospital.
  
  
  RESULTS
  The most common causes of rhabdomyolysis in general practice are represented by muscular trauma, muscle enzyme deficiencies, electrolyte abnormalities, infections, drugs, toxins and endocrine disorders. Frequent encountered clinical manifestations are weakness, myalgia and tea-colored urine, and the most sensitive laboratory finding of muscle injury is an elevated plasma creatine kinase level. The management of patients with rhabdomyolysis includes early vigorous hydration, together with specific measures (urine alkalinization, mannitol, hemodialysis).
authors.affiliation: Facultatea de Medicină, Universitatea de Medicină si Farmacie "Gr.T. Popa" Iaşi.
authors.forename: Cătălina
authors.initials: C
authors.lastname: Lionte
authors.forename: L
authors.initials: L
authors.lastname: Sorodoc
authors.forename: O
authors.initials: O
authors.lastname: Petriş
authors.forename: Victoriţa
authors.initials: V
authors.lastname: Sorodoc
authors.forename: Cristina
authors.initials: C
authors.lastname: Bologa
authors.forename: Gabriela
authors.initials: G
authors.lastname: Anton
mesh_terms: D000137:Acid-Base Imbalance / Q000150:complications; D000328:Adult; D000435:Alcoholic Intoxication / Q000150:complications; D000465:Algorithms; D015415:Biomarkers / Q000097:blood; D003141:Communicable Diseases / Q000150:complications; D003402:Creatine Kinase / Q000097:blood; D003444:Crush Syndrome / Q000150:complications; D064420:Drug-Related Side Effects and Adverse Reactions; D004700:Endocrine System Diseases / Q000150:complications; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008659:Metabolic Diseases / Q000150:complications; D008875:Middle Aged; D018908:Muscle Weakness / Q000209:etiology; D009220:Myositis / Q000209:etiology; D012189:Retrospective Studies; D012206:Rhabdomyolysis / Q000175:diagnosis* / Q000201:enzymology / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D012307:Risk Factors; D012383:Romania / Q000453:epidemiology; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; D003402:Creatine Kinase