Efficient, direct alpha-methylenation of carbonyls mediated by diisopropylammonium trifluoroacetate.
A very efficient method for the direct alpha-methylenation of carbonyl compounds, with yields up to 99%, utilizing paraformaldehyde, diisopropylammonium trifluoroacetate, and catalytic acid or base, is presented.
Bugarin
Alejandro
A
Department of Chemistry, Texas A&M University, PO Box 30012, College Station, TX 77842-3012, USA.
Jones
Kyle D
KD
Connell
Brian T
BT