Metabolites from endophytic fungus S20 of Cephalotaxus hainanensis.
Three new C-methylated acetogenins, (2E,6Z)-9,10-dihydroxy-4-hydroxymethyl-2,6-decadiene (1), (2E,6Z)-8,9,10-trihydroxy-4-hydroxymethyl-2,6-decadiene (2), and (2E,6Z)-9-hydroxy-4-hydroxymethyl-2,6-nonadiene (3), together with two known compounds, p-hydroxybenzyl alcohol (4) and indolyl-3-carboxylic acid (5), were isolated from endophytic fungus S20 of Cephalotaxus hainanensis Li. Their structures were determined based on HR-ESI-MS and spectroscopic techniques (IR, UV, 1D, and 2D NMR). Compound 5 showed inhibitory effects on Staphylococcus aureus and methicillin-resistant S. aureus by the filter paper disc agar diffusion method.
Dai
Wen-Jun
WJ
Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China.
Wu
Jiao
J
Han
Zhuang
Z
Mei
Wen-Li
WL
Dai
Hao-Fu
HF
D054378:Acetogenins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032483:Cephalotaxus / Q000382:microbiology*; D002681:China; D005658:Fungi / Q000737:chemistry; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects
C547619:(2E,6Z)-8,9,10-trihydroxy-4-hydroxymethyl-2,6-decadiene; C547620:(2E,6Z)-9,10-dihydroxy-4-hydroxymethyl-2,6-decadiene; C547621:(2E,6Z)-9-hydroxy-4-hydroxymethyl-2,6-nonadiene; D054378:Acetogenins; D000900:Anti-Bacterial Agents