Immunoglobulin preparations affect hyponatremia in Kawasaki disease.
Hyponatremia frequently occurs in Kawasaki disease (KD). The aim of this study was to investigate the effect of Na content of the intravenous immunoglobulin (IVIG) preparation on serum Na levels in KD. Seventy-eight subjects, of whom 27 had hyponatremia, were split up into two groups: group A receiving IVIG preparations containing high Na (0.9%) and group B receiving IVIG preparations containing trace Na. While the data before IVIG therapy revealed no significant differences in the median serum Na between the groups, an administration of IVIG preparations increased the serum levels of Na in group A (P < 0.01) but not in group B (P > 0.05). Furthermore, the median serum Na level was significantly higher in group A than that in group B (139.0 vs 137.0 mEq/L, respectively, P < 0.01). No significant difference was found in the prevalence of coronary artery lesions between the groups. In conclusion, we should keep it in mind that the IVIG products without Na have an adverse affect on hyponatremia in KD though their efficacy seems to be equivalent to those containing high Na.
Kaneko
Kazunari
K
Department of Pediatrics, Kansai Medical University, 2-3-l Shin-machi, Hirakata-shi, Osaka 573 1191, Japan. kanekok@hirakata.kmu.ac.jp
Hirabayashi
Masato
M
Tateiwa
Ai
A
Shimo
Tomohiko
T
Teranishi
Kenji
K
Tanaka
Sachiyo
S
Yoshimura
Ken
K
Kino
Minoru
M
Okazaki
Hitoshi
H
Harada
Yoshiaki
Y
D002626:Chemistry, Pharmaceutical / Q000379:methods; D002648:Child; D002675:Child, Preschool; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000737:chemistry* / Q000627:therapeutic use*; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy*; D015995:Prevalence; D012964:Sodium / Q000008:administration & dosage* / Q000097:blood*; D016896:Treatment Outcome; D014463:Ultrasonography
D016756:Immunoglobulins, Intravenous; D012964:Sodium