[Evaluation of antihypoxic and antiamnemonic effects of mexicor in animals].
In experiments with mice closed in airtight and altitude chambers mexicor effectiveness against hypoxia was evident only at the dose of 100 mg/kg; effect was nil against acute hemic and histotoxic hypoxia. The reference antihypoxic substance (amtisol succinate, 25-100 mg/kg) excelled mexicor in all models of acute hypoxia. In the model of cerebral infarct in rats, the mexicor neuroprotective effect at the doses from 12.5 to 100 mg/kg was dose-dependent with a nearly linear trend and significantly stronger as compared to amtisol succinate. In amnesia models in mice the antimnemonic effect of the drug at the dose of 50-100 mg/kg was much stronger than of amtisol succinate and comparable to commonly used pyracetam and oxiracetam. Mexicor (5 mM per 53 +/- 4%, 10 mM per 94 +/- 6%) inhibited the orthodromic population response in survival sections of hippocampal CA1 in rats. Stimulation of respiration of isolated mitochondria from rat's cerebral cells showed linear dose dependence in the range from 1 mM to 5 mM. It can be concluded that the antihypoxic, neuroprotective and antiamnemonic action is achievable with high mexicor dosage.
Iasnetsov
V V
VV
Karsanova
S K
SK
Ivanov
Iu V
IuV
D000647:Amnesia / Q000188:drug therapy* / Q000503:physiopathology; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000860:Hypoxia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010100:Oxygen / Q000097:blood; D011048:Polarography / Q000379:methods; D011725:Pyridines / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D016896:Treatment Outcome
D011725:Pyridines; C517040:ethylmethylhydroxypyridine succinate; D002245:Carbon Dioxide; D010100:Oxygen