title: External auditory canal and middle ear relapse of acute promyelocytic leukemia treated with arsenic trioxide: case report and review of the literature.
abstract: Extramedullary involvement occurs infrequently in acute promyelocytic leukemia and is said to be more common after treatment with all-trans retinoic acid. We describe a 9-year-old girl who had an isolated external auditory canal and middle ear relapse after treatment with all-trans retinoic acid and chemotherapy. A patient with cytogenetically and molecularly confirmed acute promyelocytic leukemia developed isolated extramedullary relapse in the auditory canal and middle ear 4 years and 9 months after initial diagnosis, while in hematologic and molecular remission, successfully treated with arsenic trioxide alone.
authors.affiliation: Department of Pediatric Hematology-Oncology, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil. tcslaf@terra.com.br
authors.forename: Thereza Christina Sampaio
authors.initials: TC
authors.lastname: Lafayette
authors.forename: Virginia Maria
authors.initials: VM
authors.lastname: Coser
authors.forename: Alice Odette
authors.initials: AO
authors.lastname: Brûlé
authors.forename: Pedro Luis
authors.initials: PL
authors.lastname: Coser
authors.forename: Waldir Veiga
authors.initials: WV
authors.lastname: Pereira
mesh_terms: D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000627:therapeutic use*; D002648:Child; D004424:Ear Canal / Q000187:drug effects / Q000473:pathology*; D004428:Ear Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D004432:Ear, Middle / Q000187:drug effects / Q000473:pathology*; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis* / Q000188:drug therapy; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D010087:Oxides / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D001152:Arsenicals; D010087:Oxides; D000077237:Arsenic Trioxide