The antiplasmodial agents of the stem bark of Entandrophragma angolense (Meliaceae).
In the search of active principles from the stem bark of Entandrophragma angolense, we submitted the compounds isolated from the dichloromethane-methanol (1:1) extract of the stem bark to antimalarial test against chloroquine resistant strain W2 of Plasmodium falciparum malaria parasite. Only 7alpha-obacunyl acetate and a cycloartane derivative exhibited a good activity, with IC(50)s of 2 and 5.4 microg/ml respectively. Other compounds were moderately active.
Bickii
Jean
J
Institut de Recherches Médicales et d'Etudes des Plantes Médicinales, Laboratoire de Recherche sur le Paludisme, Yaoundé, Cameroon. jbickii@yahoo.fr
Tchouya
Guy Raymond Feuya
GR
Tchouankeu
Jean Claude
JC
Tsamo
Etienne
E