title: Local hypothermia in the treatment of idiopathic sudden sensorineural hearing loss.
abstract: OBJECTIVE
  The additive effects of local hypothermia and restricted activity in the treatment of idiopathic sudden sensorineural hearing loss (ISSHL) were investigated by case-matched study as a multicenter (13 hospitals) pilot trial.
  
  
  METHODS
  In a preliminary experiment, we evaluated the effects of cooled water pillow (15 degrees C). Cooling the neck and mastoid with the pillow decreased the tympanic membrane temperature for 1.4 degrees C in 2h without causing uncomfortable sensation or frostbite. In this study, 86 patients with ISSHL were enrolled in the hypothermic group, which received hypothermic treatment with restricted activity in addition to medication, and 86 ISSHL patients constituted the control group, which received the same medication but without cooling and rest. Control patients were selected retrospectively from case records by matching the experimental patients with respect to age, gender, days until the start of treatment, hearing loss, shape of the audiogram, and accompanying vertigo. The patients in the hypothermic group were admitted and treated with a cooled water pillow for 48h, in addition to conventional drug treatment (e.g., 60 mg of prednisone) for 7 days. The water pillow was cooled to 15 degrees C and was changed 4-5 times per day. The patients used the water pillow for the first 48 h after admission, with restricted activity. The control patients received only the medications.
  
  
  RESULTS
  Hearing results were evaluated using criteria proposed by the Sudden Sensorineural Hearing Loss Research Group of the Japanese Ministry of Health and Welfare. The recovery rates were judged 6 months after onset. The recovery rate in the hypothermic group was significantly (p<0.05) better than that in the control group. When the comparison was limited to younger patients, the use of the cooled water pillow was effective in facilitating the recovery of hearing.
  
  
  CONCLUSIONS
  Hearing restoration in ISSHL may be improved by adding mild hypothermia and restricted activity to the conventional treatment.
authors.affiliation: Department of Otolaryngology, Ehime University School of Medicine, Shitsukawa Toon City, Ehime 791-0295, Japan. nhato@m.ehime-u.ac.jp
authors.forename: Naohito
authors.initials: N
authors.lastname: Hato
authors.forename: Jun
authors.initials: J
authors.lastname: Hyodo
authors.forename: Shoichiro
authors.initials: S
authors.lastname: Takeda
authors.forename: Daiki
authors.initials: D
authors.lastname: Takagi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okada
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Hakuba
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Gyo
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold; D016022:Case-Control Studies; D003131:Combined Modality Therapy; D017679:Cryotherapy / Q000379:methods*; D005260:Female; D003639:Hearing Loss, Sudden / Q000209:etiology / Q000628:therapy*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D012146:Rest; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000893:Anti-Inflammatory Agents; D011241:Prednisone