title: [Optimum intubating dose of rocuronium for short duration surgery in adult patients].
abstract: BACKGROUND
  The aim of this study was to examine optimum intubating dose of rocuronium in adult patients who had been scheduled for short duration surgery.
  
  
  METHODS
  Thirty patients were randomly assigned to receive rocuronium 0.4 mg x kg(-1), 0.5 mg x kg(-1) or 0.6 mg x kg(-1) during induction with propofol and fentanyl. Immediately after the adduction of thumb to the ulnar nerve stimulation could not be visually observed, the patients were intubated tracheally and the intubating conditions were evaluated. Thereafter, time to recover to train-of-four (TOF) counts of 4 was recorded during sevoflurane and nitrous oxide anesthesia.
  
  
  RESULTS
  Intubating conditions after rocuronium 0.5 and 0.6 mg x kg(-1) were all graded either excellent or good. In contrast, inadequate conditions for safe and easy tracheal intubation were observed in 60% of the patients receiving 0.4 mg x kg(-1). Time to spontaneous recover to the TOF counts of 4 correlated with the intubating doses of rocuronium.
  
  
  CONCLUSIONS
  For short duration surgeries, rocuronium 0.5 mg x kg(-1) was appropriate to perform safe tracheal intubation and minimize duration of action of rocuronium.
authors.affiliation: Department of Anesthesiology, Surugadai Nihon University Hospital, Tokyo 101-8309.
authors.forename: Tomomi
authors.initials: T
authors.lastname: Isaka
authors.forename: Takahira
authors.initials: T
authors.lastname: Suzuki
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Mizutani
authors.forename: Naoko
authors.initials: N
authors.lastname: Fukano
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saeki
authors.forename: Setsuro
authors.initials: S
authors.lastname: Ogawa
mesh_terms: D000328:Adult; D000368:Aged; D000732:Androstanols / Q000008:administration & dosage*; D000768:Anesthesia, General; D005260:Female; D005283:Fentanyl; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods*; D007830:Larynx / Q000601:surgery; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage*; D015742:Propofol; D000077123:Rocuronium; D013997:Time Factors
chemical_list: D000732:Androstanols; D003473:Neuromuscular Nondepolarizing Agents; D005283:Fentanyl; D000077123:Rocuronium; D015742:Propofol