title: Eosinophilic esophagitis: an Italian experience.
abstract: BACKGROUND
  Eosinophilic esophagitis is an esophageal disorder characterized by esophageal and/or upper gastrointestinal tract symptoms, and by dense esophageal eosinophilia associated with a normal gastric and duodenal mucosa. Prevalently reported in children, eosinophilic esophagitis has recently been reported with increased frequency also in adults.
  
  
  OBJECTIVE
  The purpose of this study was to report our experience with eosinophilic esophagitis in Italy, since there are only very few series of such patients in our country.
  
  
  METHODS
  We retrospectively reviewed the histological data of consecutive patients with a diagnosis of esophagitis or reflux disease in the period September 2004-September 2008. Eosinophils were counted where they appeared most numerous in the biopsy, with a cutoff > 15 eosinophils in more than one high-power field as diagnostic of eosinophilic esophagitis. Patients were excluded if gastric or duodenal biopsies showed a prominent eosinophilic infiltrate.
  
  
  RESULTS
  Twenty two patients (14 adults, 8 children, age range 2-59 years) were identified according to the above criteria. The average eosinophil count was 86/ high-power field (range 31-150), associated with other pathologic features (eosinophilic microabscesses eosinophil degranulation, basal zone hyperplasia, papillary elongation). The main clinical complaints were dysphagia, food impaction, and heartburn, and endoscopic findings consisted of mucosal thickening and inelasticity, longitudinal shearing, rings, and white specks, without difference between adults and children for both clinical and endoscopic variables.
  
  
  CONCLUSIONS
  Eosinophilic esophagitis is not rare in Italy, and displays clinical, endoscopic, and pathologic features similar to those described in other countries.
authors.affiliation: Division of Pathological Anatomy, AOUS, Siena, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Vindigni
authors.forename: V
authors.initials: V
authors.lastname: Villanacci
authors.forename: M
authors.initials: M
authors.lastname: Marini
authors.forename: B J
authors.initials: BJ
authors.lastname: Rocca
authors.forename: G
authors.initials: G
authors.lastname: Frosini
authors.forename: E
authors.initials: E
authors.lastname: Pedruzzi
authors.forename: N
authors.initials: N
authors.lastname: Corazzi
authors.forename: Gabrio
authors.initials: G
authors.lastname: Bassotti
authors.forename: P
authors.initials: P
authors.lastname: Tosi
mesh_terms: D000038:Abscess / Q000209:etiology / Q000473:pathology; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D015550:Cell Degranulation; D002648:Child; D002675:Child, Preschool; D004548:Elasticity; D004802:Eosinophilia / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology; D004941:Esophagitis / Q000453:epidemiology* / Q000276:immunology / Q000473:pathology; D004945:Esophagoscopy; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult