title: OncoRx-IQ: a tool for quality assessment of online anticancer drug interactions.
abstract: OBJECTIVE
  The quality of online anticancer drug interaction information varies among online drug databases. We describe the creation of OncoRx-IQ, a tool which assesses the information quality of online drug databases for anticancer drug interactions, and a pilot study done with the tool.
  
  
  METHODS
  OncoRx-IQ was designed in the form of a questionnaire containing 25 questions in three quality domains, separated into two sections (Section A: content accuracy and Section B: ease-of-use and reliability). Each question was scored based on the number of options assigned.
  
  
  METHODS
  A pilot study utilizing this tool was done on four drug databases (Drugs.com, Drug Digest, Medscape and Micromedex). Statistical analyses of the composite and domain scores were done using descriptive statistics, Spearman's correlation coefficient and Friedman and Wilcoxon signed-rank tests.
  
  
  METHODS
  Six pre-registration pharmacists participated in the pilot study.
  
  
  METHODS
  The drug databases were evaluated based on the accuracy of their drug interaction content, usability and reliability, as well as their overall quality.
  
  
  RESULTS
  Micromedex (66.9%) and Drug Digest (35.8%) were the highest and lowest scoring databases, respectively. Micromedex scored the highest in all quality domains (content accuracy 56.3%, ease-of-use 75.0% and reliability 73.6%), whereas Drug Digest scored the lowest in content accuracy (8.0%) and reliability (48.2%).
  
  
  CONCLUSIONS
  We have created and pilot-tested OncoRx-IQ, a quality assessment tool, which helps clinicians systematically evaluate the quality and information accuracy of drug databases for anticancer drug interaction information. We hope this tool can lay the groundwork for future long-term evaluation of online drug interaction information.
authors.affiliation: Department of Pharmacy, National University of Singapore, Singapore.
authors.forename: Kevin Yi-Lwern
authors.initials: KY
authors.lastname: Yap
authors.forename: Sreemanee
authors.initials: S
authors.lastname: Raaj
authors.forename: Alexandre
authors.initials: A
authors.lastname: Chan
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects*; D016208:Databases, Factual; D004347:Drug Interactions; D006801:Humans; D020407:Internet; D010865:Pilot Projects; D011795:Surveys and Questionnaires
chemical_list: D000970:Antineoplastic Agents