Role of transient receptor potential and acid-sensing ion channels in peripheral inflammatory pain.
Pain originating in inflammation is the most common pathologic pain condition encountered by the anesthesiologist whether in the context of surgery, its aftermath, or in the practice of pain medicine. Inflammatory agents, released as components of the body's response to peripheral tissue damage or disease, are now known to be collectively capable of activating transient receptor potential vanilloid type 1, transient receptor potential vanilloid type 4, transient receptor potential ankyrin type 1, and acid-sensing ion channels, whereas individual agents may activate only certain of these ion channels. These ionotropic receptors serve many physiologic functions-as, indeed, do many of the inflammagens released in the inflammatory process. Here, we introduce the reader to the role of these ionotropic receptors in mediating peripheral pain in response to inflammation.
White
John P M
JP
Section of Anaesthetics, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, Chelsea and Westminster Hospital, London, United Kingdom.
Cibelli
Mario
M
Rei Fidalgo
Antonio
A
Paule
Cleoper C
CC
Noormohamed
Faruq
F
Urban
Laszlo
L
Maze
Mervyn
M
Nagy
Istvan
I
D062565:Acid Sensing Ion Channels; D018685:Anesthetics, Inhalation / Q000494:pharmacology; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000150:complications / Q000503:physiopathology*; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000502:physiology*; D010146:Pain / Q000209:etiology / Q000503:physiopathology*; D015222:Sodium Channels / Q000187:drug effects / Q000502:physiology*; D050051:Transient Receptor Potential Channels / Q000187:drug effects / Q000502:physiology*
D062565:Acid Sensing Ion Channels; D018685:Anesthetics, Inhalation; D009419:Nerve Tissue Proteins; D015222:Sodium Channels; D050051:Transient Receptor Potential Channels