ESI FTICR-MS analysis of larvae from the marine sponge Luffariella variabilis.
The viviparous Great Barrier Reef sponge Luffariella variabilis (Poléjaeff 1884) contains a range of secondary metabolites, including manoalide (1) and manoalide monoacetate (3). ESI (+) FTICR-MS accurate mass determination has, for the first time, been used to detected the presence of 3 only in an organic extract of a single L. variabilis larva showing that the parentally produced 3 is sequestered in the larva. As 3 has previously been shown to have antibacterial and quorum sensing inhibition activity, and readily converts to 1, which also exhibits similar activity, it may provide a chemical defence against predation and microbial attack.
Motti
Cherie A
CA
Australian Institute of Marine Science, Townsville, Queensland, 4810, Australia. c.motti@aims.gov.au
Ettinger-Epstein
Piers
P
Willis
Richard H
RH
Tapiolas
Dianne M
DM
D000085:Acetates / Q000032:analysis* / Q000737:chemistry; D053000:Analytic Sample Preparation Methods; D000818:Animals; D000900:Anti-Bacterial Agents / Q000032:analysis / Q000737:chemistry; D007814:Larva / Q000737:chemistry; D008387:Marine Toxins / Q000032:analysis / Q000737:chemistry; D008832:Microchemistry / Q000379:methods; D015394:Molecular Structure; D010140:Pacific Ocean; D011161:Porifera / Q000737:chemistry*; D011793:Queensland; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods*; D013729:Terpenes / Q000032:analysis* / Q000737:chemistry
D000085:Acetates; D000900:Anti-Bacterial Agents; D008387:Marine Toxins; D013729:Terpenes; C045673:manoalide