Human intestinal microbiota gene risk factors for antibiotic-associated diarrhea: perspectives for prevention. Risk factors for antibiotic-associated diarrhea.
Antibiotic-associated diarrhea (AAD) is associated with altered intestinal microflora and other symptoms that may lead to possibly death. In critically ill patients, diarrhea increases rates of morbimortality. Assessing diarrhea risks is thus important for clinicians. For this reason, we conducted a hypothesis-generating study focused on AAD to provide insight into methods of prevention. We evaluated the hypothesis of predisposing factors within the resident intestinal microbiota in a cohort of outpatients receiving antibiotherapy. Among the pool of tested variables, only those related to bacterial 16S rRNA genes were found to be relevant. Complex statistical analyses provided further information: amid the bacteria 16S rRNA genes, eight were determined to be essential for diarrhea predisposition and characterized from the most important to the least. Using these markers, AAD risk could be estimated with an error of 2%. This molecular analysis offers new perspectives for clinical applications at the level of prevention.
de La Cochetière
Marie-France
MF
Thérapeutiques Cliniques et Expérimentales des Infections, EA3826, Université de Nantes - INSERM, UFR Médecine, 1 rue Gaston Veil, Nantes, 44000, France. marie-france.de-la-cochetiere@inserm.fr
Montassier
Emmanuel
E
Hardouin
Jean-Benoit
JB
Carton
Thomas
T
Le Vacon
Françoise
F
Durand
Tony
T
Lalande
Valerie
V
Petit
Jean Claude
JC
Potel
Gilles
G
Beaugerie
Laurent
L
D000328:Adult; D000704:Analysis of Variance; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001419:Bacteria / Q000235:genetics*; D003967:Diarrhea / Q000139:chemically induced / Q000517:prevention & control*; D004198:Disease Susceptibility / Q000382:microbiology*; D005798:Genes, Bacterial; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D054892:Metagenome; D008875:Middle Aged; D015999:Multivariate Analysis; D012329:RNA, Bacterial / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012307:Risk Factors; D055815:Young Adult
D000900:Anti-Bacterial Agents; D012329:RNA, Bacterial; D012336:RNA, Ribosomal, 16S