title: Psoriasis vulgaris and digestive system disorders: is there a linkage?
abstract: Psoriasis is well-known immune-mediated skin disease often associated with co-morbidities, including dyslipidaemia and obesity. Few reports imply that the disease might be also related to pathology of mucosal surfaces, especially that of the digestive system. The authors present a case of psoriasis and concurrent digestive system abnormalities, and review the literature regarding the topic. A 40-year-old man suffered from an exacerbation of exudative psoriasis for about 6 months. Topical antipsoriatics proved ineffective and the disease gradually progressed to a severe disseminated form. Subsequent detailed examinations revealed persistent gastroduodenitis due to H. pylori infection, pancreatic dysfunction and fatty change of the liver, although the patient denied any gastrointestinal symptoms. As a result appropriate treatment of the diagnosed digestive system disorders was added to topical antipsoriatic therapy. Within 2 weeks of treatment clinical symptoms and laboratory signs showed a marked trend to normalisation. The presented medical history seems to suggest that there may be some kind of interplay between psoriasis and digestive system disorders.
authors.affiliation: Department of Dermatology, Medical University of Lublin, Lublin, Poland.
authors.forename: Aldona
authors.initials: A
authors.lastname: Pietrzak
authors.forename: Iwona
authors.initials: I
authors.lastname: Jastrzebska
authors.forename: Grazyna
authors.initials: G
authors.lastname: Chodorowska
authors.forename: Ryszard
authors.initials: R
authors.lastname: Maciejewski
authors.forename: Ewa
authors.initials: E
authors.lastname: Dybiec
authors.forename: Maria
authors.initials: M
authors.lastname: Juszkiewicz-Borowiec
authors.forename: Dorota
authors.initials: D
authors.lastname: Krasowska
authors.forename: Robert A
authors.initials: RA
authors.lastname: Schwartz
mesh_terms: D000328:Adult; D002974:Clemastine / Q000627:therapeutic use; D004066:Digestive System Diseases / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D018450:Disease Progression; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D016593:Terfenadine / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D016593:Terfenadine; D002974:Clemastine; C093230:fexofenadine