Comparative rheumatology: what can be learnt from naturally occurring musculoskeletal disorders in domestic animals?
Examples of naturally occurring musculoskeletal disorders are extremely common in veterinary species and provide a valuable comparative research resource, which can provide compelling comparative data on the aetiopathogenesis and treatment of many common human musculoskeletal diseases. In particular, orthopaedic diseases are a common morbidity in both dogs and horses. In this review, we give an overview of the common musculoskeletal diseases encountered in these species: for instance, tendon and ligament injuries, arthropathies and stress fractures, as well as an insight into the basic biology of these conditions. In doing so, we aim to demonstrate the similarities and differences between these disorders and similar conditions in man.
Innes
John F
JF
Musculoskeletal Research Group, Department of Comparative Molecular Medicine, School of Veterinary Science, University of Liverpool, Leahurst Campus, Neston, Cheshire CH64 7TE, UK. j.f.innes@liv.ac.uk
Clegg
Peter
P
D000818:Animals; D000829:Animals, Domestic; D001168:Arthritis / Q000235:genetics / Q000503:physiopathology* / Q000662:veterinary; D001947:Breeding; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000235:genetics / Q000503:physiopathology; D004285:Dogs; D005260:Female; D020022:Genetic Predisposition to Disease; D006734:Horse Diseases / Q000235:genetics / Q000503:physiopathology; D006736:Horses; D006801:Humans; D008022:Ligaments / Q000293:injuries*; D008297:Male; D009140:Musculoskeletal Diseases / Q000235:genetics / Q000503:physiopathology* / Q000662:veterinary; D010375:Pedigree; D012307:Risk Factors; D013708:Tendon Injuries / Q000503:physiopathology*