title: Intraperitoneal paclitaxel as consolidation treatment in ovarian cancer patients: a case control study.
abstract: OBJECTIVE
  It was the aim of this study to assess the role, feasibility and safety of consolidation intraperitoneal (IP) paclitaxel in patients affected by advanced ovarian cancer.
  
  
  METHODS
  Patients affected by advanced ovarian cancer with complete pathological response after standard treatment were enrolled in this study. The consolidation chemotherapy schedule consisted of 12-16 cycles of IP paclitaxel, 60 mg/mq weekly (group A). Chemotherapy was delivered with a direct puncture under ultrasonographic guidance at each cycle. Survival data of this group of patients were compared with those from a control group with analogous characteristics submitted to observation only (group B).
  
  
  RESULTS
  Seventy patients were included in the study, 28 in group A and 42 in group B. Treatment-related toxicity was mild. In 3/28 patients (11%), technical difficulties in accessing the peritoneum were observed. Median time to recurrence was 25 months (range 4-64) in group A and 17.5 months (range 2-60) in group B. Estimated 3-year disease-free survival was 56 and 33% (p < 0.05) in group A and B, respectively; no significant difference in 3-year overall survival was observed (87 vs. 83%; p value not significant).
  
  
  CONCLUSIONS
  Weekly IP consolidation chemotherapy with paclitaxel 60 mg/mq is well tolerated and, in this experience, a prolongation of progression-free survival was observed.
authors.affiliation: Department of Obstetrics and Gynecology, La Sapienza University of Rome, Viale del Policlinico 155, IT-00155 Rome, Italy. pierluigi.benedettipanici@uniroma1.it
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Benedetti Panici
authors.forename: Innocenza
authors.initials: I
authors.lastname: Palaia
authors.forename: Marialida
authors.initials: M
authors.lastname: Graziano
authors.forename: Filippo
authors.initials: F
authors.lastname: Bellati
authors.forename: Natalina
authors.initials: N
authors.lastname: Manci
authors.forename: Roberto
authors.initials: R
authors.lastname: Angioli
mesh_terms: D000328:Adult; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage* / Q000627:therapeutic use; D016022:Case-Control Studies; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D017239:Paclitaxel / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D017239:Paclitaxel