title: Caffeine increases cerebral cortical activity in preterm infants.
abstract: Caffeine improves the rate of survival without neurodevelopmental disability in preterm infants. The mechanisms underlying neuroprotection are incompletely understood. In 51 preterm infants studied by amplitude-integrated electroencephalography from 2 hours before to 2 hours after intravenous caffeine administration, we found that caffeine increases amplitudes and periods of continuity.
authors.affiliation: Department of Neonatology and Pediatric Intensive Care, Vest Children's Hospital, University of Witten-Herdecke, Datteln, Germany.
authors.forename: Sirma
authors.initials: S
authors.lastname: Supcun
authors.forename: Patrizia
authors.initials: P
authors.lastname: Kutz
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Pielemeier
authors.forename: Claudia
authors.initials: C
authors.lastname: Roll
mesh_terms: D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D004569:Electroencephalography / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007262:Infusions, Intravenous; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D018696:Neuroprotective Agents; D002110:Caffeine