Studies of insect peptides alloferon, Any-GS and their analogues. Synthesis and antiherpes activity.
The subject of these studies was synthesis and determination of biological properties of a series of insect peptides, such as alloferon, Any-GS and their analogues. The synthesis of 14 peptides was performed by the solid-phase method. Biological effect of these peptides was evaluated by the antiviral test against Human Herpes Virus type 1 (HHV-1) in vitro using a Vero cell line. It was found that the investigated peptides inhibit the replication of HHV-1 in Vero cells.
Kuczer
Mariola
M
Faculty of Chemistry, University of Wroclaw, 14 F. Joliot-Curie Street, Wroclaw, Poland. km@wchuwr.chem.uni.wroc.pl
Dziubasik
Katarzyna
K
Midak-Siewirska
Anna
A
Zahorska
Renata
R
Łuczak
Mirosław
M
Konopińska
Danuta
D
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D002851:Chromatography, High Pressure Liquid; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D019476:Insect Proteins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014709:Vero Cells
C510535:Alloferon; D000998:Antiviral Agents; D019476:Insect Proteins; D010455:Peptides