Novel powerful water-soluble lipid immunoadjuvants inducing mouse dendritic cell maturation and B cell proliferation using TLR2 pathway.
Four novel water-soluble lipid immunoadjuvants were designed, synthesized and characterized by MS and NMR. They all induce mouse dendritic cell maturation and B cell proliferation. We demonstrate that in spite of the chemical modification, the four compounds remain TLR2 agonists.
Spanedda
Maria Vittoria
MV
Equipe de Biovectorologie, Laboratoire de Conception et Application des Molécules Bioactives, UMR 7199 CNRS/Université de Strasbourg, Faculté de Pharmacie, Illkirch Cedex, France.
Heurtault
Béatrice
B
Weidner
Steffen
S
Baehr
Corinne
C
Boeglin
Emmanuelle
E
Beyrath
Julien
J
Milosevic
Sara
S
Bourel-Bonnet
Line
L
Fournel
Sylvie
S
Frisch
Benoît
B
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D049109:Cell Proliferation / Q000187:drug effects*; D003713:Dendritic Cells / Q000166:cytology*; D008055:Lipids / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D012995:Solubility; D051195:Toll-Like Receptor 2 / Q000378:metabolism*; D014867:Water
D000276:Adjuvants, Immunologic; D008055:Lipids; C493486:Tlr2 protein, mouse; D051195:Toll-Like Receptor 2; D014867:Water