The next generation of burns treatment: intelligent films and matrix, controlled enzymatic debridement, and adult stem cells.
We describe a novel technology based on nanoengineered multifunctional acellular biologic scaffolds combined with wound dressings and films of the same kind. This method allows selective delivery and release of shielded biomaterials and bioactive substances to a desired wound or damaged tissue while stimulating the selective anchoring and adhesion of endogenous circulating repairing cells, such as mesenchymal stem cells, to obtain a faster and more physiologic healing process. We also present a new controlled enzymatic debridement process for more effective burned tissue scarolysis. In light of our preliminary in vitro and in vivo data, we are convinced that these approaches can include the use of other kinds of adult stem cells, such as endometrial regenerative cells, to improve the vascularization of the constructs, with great potential in the entire tissue and organ regeneration field but especially for the treatment of severely burned patients, changing the way these lesions may be treated in the future.
Drago
H
H
Banco de Tejidos, Hospital de Quemados, CABA, Argentina.
Marín
G H
GH
Sturla
F
F
Roque
G
G
Mártire
K
K
Díaz Aquino
V
V
Lamonega
R
R
Gardiner
C
C
Ichim
T
T
Riordan
N
N
Raimondi
J C
JC
Bossi
S
S
Samadikuchaksaraei
A
A
van Leeuwen
M
M
Tau
J M
JM
Núñez
L
L
Larsen
G
G
Spretz
R
R
Mansilla
E
E
D000328:Adult; D000818:Animals; D001458:Bandages; D001773:Blood Cells / Q000166:cytology; D001808:Blood Vessels / Q000502:physiology; D002056:Burns / Q000473:pathology / Q000601:surgery*; D002102:Cadaver; D029441:Carica; D002921:Cicatrix / Q000517:prevention & control; D003646:Debridement / Q000379:methods*; D020405:Dermis / Q000473:pathology; D004847:Epithelial Cells / Q000637:transplantation; D006801:Humans; D019520:Living Donors; D008598:Menstruation / Q000502:physiology; D012038:Regeneration; D033581:Stem Cell Transplantation / Q000379:methods*; D013552:Swine; D014019:Tissue Donors; D014182:Transplantation, Autologous; D014183:Transplantation, Heterologous / Q000379:methods