Analysis of tissue factor positive microparticles.
There has recently been intense interest in the clinical measurement of tissue factor (TF)-positive microparticles (MPs) in clinical disease states. This interest has been driven by the demonstration of an putative role for circulating TF-positive MPs in animal models of thrombus propagation. Both immunological and functional assays for MP-TF have been described. While each approach has its own advantages and drawbacks, neither has yet been truly established as the 'gold standard'. Heterogeneity of TF-bearing MPs, such as the variable co-expression of surface phosphatidylserine, may determine not only their procoagulant potential, but also additional properties including rate of clearance from the circulation.
Key
Nigel S
NS
Department of Medicine, Division of Hematology/Oncology, University of North Carolina at Chapel Hill, NC 27599, USA. Nigel_key@med.unc.edu
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001777:Blood Coagulation; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D004195:Disease Models, Animal; D006801:Humans; D007107:Immune System; D008954:Models, Biological; D010316:Particle Size; D010718:Phosphatidylserines / Q000737:chemistry; D013917:Thrombin / Q000378:metabolism; D013925:Thromboplastin / Q000378:metabolism*; D013927:Thrombosis / Q000378:metabolism
D015415:Biomarkers; D010718:Phosphatidylserines; D013925:Thromboplastin; D013917:Thrombin