Scandium triflate-catalyzed one-pot domino approach towards general and efficient syntheses of unsymmetrical 9-substituted xanthene derivatives.
A general and efficient one-pot cascade/tandem approach to synthesize unsymmetrical 9-aryl/heteroaryl xanthenes has been developed under extremely mild reaction conditions using 10 mol% Sc(OTf)(3) as a catalyst. This strategy has been further extended to synthesize 9-(thioaryl) xanthenes through tandem carbon-sulfur (C-S) and carbon-carbon (C-C) bond formation. Novel C-C and C-S bond cleavage promoted by Sc(OTf)(3) is also discussed during mechanistic investigation.
Singh
Ritesh
R
Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Chattar Manzil Palace, Lucknow, 226001, UP, India.
Panda
Gautam
G
D002384:Catalysis; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D012538:Scandium / Q000737:chemistry*; D014966:Xanthenes / Q000138:chemical synthesis* / Q000737:chemistry
D008698:Mesylates; D014966:Xanthenes; C436603:scandium triflate; D012538:Scandium