title: Stereoselective hydrogenation on the exocyclic and conjugated double bond of sesquiterpene lactones by Aspergillus versicolor D-1.
abstract: Aspergillus versicolor D-1 was employed to convert dehydrocostuslactone (1) and 3-hydroxy-1(10),3,11(13)-guaiatriene-12,6-olide-2-one (5) stereoselectively. The reactions occurring were specific hydrogenation on the exocyclic alpha,beta-double bond of sesquiterpene lactones with excellent conversion. Products were identified by the analysis of their spectra such as UV, IR, MS, (1)H, (13)C NMR, and NOESY, and the structure of one new compound was elucidated. The characteristic of the stereoselective hydrogenation was also discussed and suggested.
authors.affiliation: School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Hong
authors.initials: H
authors.lastname: Guan
authors.forename: Yi-Nan
authors.initials: YN
authors.lastname: Chen
authors.forename: Wei-Zhuo
authors.initials: WZ
authors.lastname: Xu
authors.forename: Song
authors.initials: S
authors.lastname: You
mesh_terms: D001230:Aspergillus / Q000378:metabolism*; D006865:Hydrogenation; D007783:Lactones / Q000737:chemistry* / Q000378:metabolism; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012717:Sesquiterpenes / Q000737:chemistry* / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: D007783:Lactones; D012717:Sesquiterpenes; C083030:dehydrocostus lactone