Regioselective reactions of highly substituted arynes.
The fully regioselective reactivity of four new highly substituted silyl aryl triflate aryne precursors in aryne acyl-alkylation, acyl-alkylation/condensation, and heteroannulation reactions is reported. The application of these more complex arynes provides access to diverse natural product scaffolds and obviates late-stage functionalization of aromatic rings.
Tadross
Pamela M
PM
The Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.
Gilmore
Christopher D
CD
Bugga
Pradeep
P
Virgil
Scott C
SC
Stoltz
Brian M
BM
D000478:Alkylation; D000480:Alkynes / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D000480:Alkynes