Asymmetric cyanation of activated olefins with ethyl cyanoformate catalyzed by a modular titanium catalyst.
Asymmetric cyanation of a class of easily available olefins with a favorable cyanide source ethyl cyanoformate (CNCOOEt) was realized by an interesting modular catalyst. High yields and ee values were obtained for a range of substrates under solvent-free and mild reaction conditions. The products obtained could be easily transformed to the enantioenriched useful intermediates 5, 6, and pharmaceutically important gamma-aminobutyric acid 7.
Wang
Jun
J
Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, PR China.
Li
Wei
W
Liu
Yanling
Y
Chu
Yangyang
Y
Lin
Lili
L
Liu
Xiaohua
X
Feng
Xiaoming
X
D000097:Acetonitriles / Q000737:chemistry*; D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*; D005680:gamma-Aminobutyric Acid / Q000138:chemical synthesis* / Q000737:chemistry
D000097:Acetonitriles; D000475:Alkenes; D005680:gamma-Aminobutyric Acid; D014025:Titanium