title: Treephyler: fast taxonomic profiling of metagenomes.
abstract: CONCLUSIONS
  Assessment of phylogenetic diversity is a key element to the analysis of microbial communities. Tools are needed to handle next-generation sequencing data and to cope with the computational complexity of large-scale studies. Here, we present Treephyler, a tool for fast taxonomic profiling of metagenomes. Treephyler was evaluated on real metagenome to assess its performance in comparison to previous approaches for taxonomic profiling. Results indicate that Treephyler is in terms of speed and accuracy prepared for next-generation sequencing techniques and large-scale analysis.
  
  
  BACKGROUND
  Treephyler is implemented in Perl; it is portable to all platforms and applicable to both nucleotide and protein input data. Treephyler is freely available for download at http://www.gobics.de/fabian/treephyler.php.
authors.affiliation: Abteilung Bioinformatik, Institut für Mikrobiologie und Genetik, Georg-August-Universität Göttingen, Goldschmidtstrasse 1, 37077 Göttingen, Germany. fschrei@gwdg.de
authors.forename: Fabian
authors.initials: F
authors.lastname: Schreiber
authors.forename: Peter
authors.initials: P
authors.lastname: Gumrich
authors.forename: Rolf
authors.initials: R
authors.lastname: Daniel
authors.forename: Peter
authors.initials: P
authors.lastname: Meinicke
mesh_terms: D016208:Databases, Factual; D023281:Genomics / Q000379:methods*; D054892:Metagenome; D010802:Phylogeny; D012984:Software