Controlled release from directly compressible theophylline buccal tablets.
The aim of the current study was the development of theophylline buccal adhesive tablets using direct compression. Buccal adhesive formulations were developed using a water soluble resin with various combinations of mucoadhesive polymers. The prepared theophylline tablets were evaluated for tensile strength, swelling capacity and ex vivo mucoadhesion performance. Ex vivo mucoadhesion was assessed using porcine gingival tissue and the peak detachment forces were found to be suitable for a buccal adhesive tablet with a maximum of 1.5 N approximately. The effect of formulation composition on the release pattern was also investigated. Most formulations showed theophylline controlled release profiles depended on the grade and polymer ratio. The release mechanisms were found to fit Peppas' kinetic model over a period of 5h. In general the majority of the developed formulations presented suitable adhesion and controlled drug release.
Boyapally
Harikrishna
H
Greenwich University, School of Science, Medway Campus, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK.
Nukala
Ravi Kumar
RK
Bhujbal
Pranav
P
Douroumis
Dennis
D
D000268:Adhesiveness; D000278:Administration, Buccal; D000818:Animals; D002610:Cheek; D003692:Delayed-Action Preparations / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D005881:Gingiva / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008422:Materials Testing; D011108:Polymers / Q000737:chemistry; D013552:Swine; D013607:Tablets; D013718:Tensile Strength; D013806:Theophylline / Q000737:chemistry*
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D011108:Polymers; D013607:Tablets; D013806:Theophylline