title: Lung volumes, ventricular function and pulmonary arterial flow in children operated on for left-sided congenital diaphragmatic hernia: long-term results.
abstract: OBJECTIVE
  To compare MRI-based functional pulmonary and cardiac measurements in the long-term follow-up of children operated on for left-sided congenital diaphragmatic hernia (CDH) with age- and body size-matched healthy controls.
  
  
  METHODS
  Twelve children who received immediate postnatal surgery for closure of isolated left-sided CDH were included and received basic medical examinations, pulmonary function testing and echocardiography. MRI included measurement of lung volume, ventricular function assessment and velocity-encoded imaging of the pulmonary arteries and was compared with the data for 12 healthy children matched for age and body size.
  
  
  RESULTS
  While patients' clinical test results were not suspicious, comparison between the MRI data for patients and those for healthy controls revealed significant differences. In patients, the volumes of the left lungs were increased and the tidal volume was larger on the right side. While the stroke volumes of both ventricles were reduced, heart rate and ejection fraction were increased. Flow, acceleration time and cross-sectional area of the left pulmonary artery were reduced.
  
  
  CONCLUSIONS
  Functional MRI detected pulmonary and cardiac findings in the late follow-up of CDH children which may be missed by standard clinical methods and might be relevant for decisions regarding late outcome and treatment.
authors.affiliation: OncoRay-Molecular and Biological Imaging, Medical Faculty Carl Gustav Carus, Dresden University of Technology, Dresden, Germany. Nasreddin.Abolmaali@OncoRay.de
authors.forename: Nasreddin
authors.initials: N
authors.lastname: Abolmaali
authors.forename: Arne
authors.initials: A
authors.lastname: Koch
authors.forename: Knut
authors.initials: K
authors.lastname: Götzelt
authors.forename: Gabriele
authors.initials: G
authors.lastname: Hahn
authors.forename: Guido
authors.initials: G
authors.lastname: Fitze
authors.forename: Christian
authors.initials: C
authors.lastname: Vogelberg
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006548:Hernia, Diaphragmatic / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D008168:Lung / Q000473:pathology; D008176:Lung Volume Measurements; D008279:Magnetic Resonance Imaging; D008297:Male; D015588:Observer Variation; D011651:Pulmonary Artery / Q000502:physiology*; D012015:Reference Standards; D016277:Ventricular Function, Left / Q000502:physiology*