Layers upon layers: MHC class I acts in the retina to influence thalamic segregation.
Recent research has introduced the major histocompatibility complex class I (MHCI) genes as unexpected players in structural and synaptic plasticity in the central nervous system. In this issue of Neuron, Xu et al. redirect current theory by providing strong evidence for the inner retina as a site of action of MHCI proteins in retinogeniculate refinement.
Higenell
Valerie
V
Montreal Neurological Institute, McGill University, Montréal, Québec H3A 2B4, Canada.
Ruthazer
Edward S
ES
D000818:Animals; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D051379:Mice; D009474:Neurons / Q000378:metabolism; D012160:Retina / Q000378:metabolism*; D013788:Thalamus / Q000502:physiology*; D014795:Visual Pathways / Q000378:metabolism
D015395:Histocompatibility Antigens Class I