title: Chemoselective deprotection of triethylsilyl ethers.
abstract: An efficient and selective method was developed for the deprotection of triethylsilyl (TES) ethers using formic acid in methanol (5-10%) or in methylene chloride 2-5%) with excellent yields. TES ethers are selectively deprotected to the corresponding alcohols in high yields using formic acid in methanol under mild reaction conditions. Other hydroxyl protecting groups like t-butyldimethylsilyl (TBDMS) remain unaffected.
authors.affiliation: Department of Chemistry and Biochemistry Montana State University, Bozeman, MT 59717, USA.
authors.forename: Tilak
authors.initials: T
authors.lastname: Chandra
authors.forename: William E
authors.initials: WE
authors.lastname: Broderick
authors.forename: Joan B
authors.initials: JB
authors.lastname: Broderick
mesh_terms: D004987:Ethers / Q000737:chemistry*; D005561:Formates / Q000737:chemistry; D000432:Methanol / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
chemical_list: D004987:Ethers; D005561:Formates; D014297:Trimethylsilyl Compounds; C030544:formic acid; D000432:Methanol