title: SJLB mice develop tauopathy-induced parkinsonism.
abstract: Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) is an inherited dementia caused by tauopathy. Recently, we established the N279K mutant human tau transgenic mice SJLB. Although SJLB mice show cognitive dysfunction with insoluble tau in the brain, it has remained unclear whether they show signs of parkinsonism. To clarify this issue, we studied whether SJLB mice in fact develop parkinsonism. Behavioral analysis showed shorter stride length than that of non-transgenic control mice in the footprint test and movement disorder in the pole test, thus mimicking some features of human parkinsonism. We also found that these symptoms were not affected by dopamine treatment. These results indicate that SJLB mice show signs of parkinsonism and they could be of usefulness not only for studies of dementing disease but also of parkinsonism induced by tauopathy.
authors.affiliation: Department of Pharmaceutical Health Care, Faculty of Pharmaceutical Sciences, Himeji Dokkyo University, 7-2-1 Kamiohno, Himeji, Hyogo 670-8524, Japan.
authors.forename: Mariko
authors.initials: M
authors.lastname: Takenokuchi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kadoyama
authors.forename: Shunmei
authors.initials: S
authors.lastname: Chiba
authors.forename: Miho
authors.initials: M
authors.lastname: Sumida
authors.forename: Shogo
authors.initials: S
authors.lastname: Matsuyama
authors.forename: Katsuyasu
authors.initials: K
authors.lastname: Saigo
authors.forename: Taizo
authors.initials: T
authors.lastname: Taniguchi
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation; D020734:Parkinsonian Disorders / Q000235:genetics* / Q000523:psychology; D024801:Tauopathies / Q000235:genetics* / Q000523:psychology; D016875:tau Proteins / Q000235:genetics*
chemical_list: C054369:MAPT protein, human; D016875:tau Proteins