title: Genetic association between CALHM1, 2, and 3 polymorphisms and Alzheimer's disease in a Japanese population.
abstract: A recent paper reported that a variant (rs2986017) of the calcium homeostasis modulator 1 (CALHM1) gene affects risk for late-onset Alzheimer's disease (AD). This study aims to investigate whether single nucleotide polymorphisms (SNPs) of the CALHM1 gene are associated with AD. SNPs in the genes of two other CALHM subtypes, CALHM2 and CALHM3, were also studied. Our study failed to detect any association between the SNPs of the three genes and AD. Although rs729211 showed marginal association in the APOE4 negative group, the linkage disequilibrium analysis results suggest this to be a false positive.
authors.affiliation: Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan. nobuto.shibata@nifty.ne.jp
authors.forename: Nobuto
authors.initials: N
authors.lastname: Shibata
authors.forename: Bolati
authors.initials: B
authors.lastname: Kuerban
authors.forename: Miwa
authors.initials: M
authors.lastname: Komatsu
authors.forename: Tohru
authors.initials: T
authors.lastname: Ohnuma
authors.forename: Hajime
authors.initials: H
authors.lastname: Baba
authors.forename: Heii
authors.initials: H
authors.lastname: Arai
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000208:ethnology* / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D015220:Calcium Channels / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods; D005838:Genotype; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium / Q000502:physiology; D008297:Male; D008562:Membrane Glycoproteins / Q000145:classification / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012044:Regression Analysis
chemical_list: D053327:Apolipoprotein E4; C530077:CALHM1 protein, human; D015220:Calcium Channels; D008562:Membrane Glycoproteins