title: A novel method for blood vessel detection from retinal images.
abstract: BACKGROUND
  The morphological changes of the retinal blood vessels in retinal images are important indicators for diseases like diabetes, hypertension and glaucoma. Thus the accurate segmentation of blood vessel is of diagnostic value.
  
  
  METHODS
  In this paper, we present a novel method to segment retinal blood vessels to overcome the variations in contrast of large and thin vessels. This method uses adaptive local thresholding to produce a binary image then extract large connected components as large vessels. The residual fragments in the binary image including some thin vessel segments (or pixels), are classified by Support Vector Machine (SVM). The tracking growth is applied to the thin vessel segments to form the whole vascular network.
  
  
  RESULTS
  The proposed algorithm is tested on DRIVE database, and the average sensitivity is over 77% while the average accuracy reaches 93.2%.
  
  
  CONCLUSIONS
  In this paper, we distinguish large vessels by adaptive local thresholding for their good contrast. Then identify some thin vessel segments with bad contrast by SVM, which can be lengthened by tracking. This proposed method can avoid heavy computation and manual intervention.
authors.affiliation: School of Biomedical Engineering, Capital Medical University, Beijing, China.
authors.forename: Lili
authors.initials: L
authors.lastname: Xu
authors.forename: Shuqian
authors.initials: S
authors.lastname: Luo
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012171:Retinal Vessels / Q000033:anatomy & histology*; D042262:Retinoscopy / Q000379:methods*; D012680:Sensitivity and Specificity