title: Abdominal undifferentiated small round cell tumor with unique translocation (X;19)(q13;q13.3).
abstract: We describe a male with a large abdominal mass, most likely originating from the liver, with capsule rupture and tumor dissemination into the abdominal cavity. Adherence of the tumor to the diaphragm and lower right colon also were noted. A comprehensive evaluation of the mass revealed no tumor-defining histopathologic, immunocytochemical, ultrastructural, cytogenetic, or translocation features. The malignant tumor was found to have a novel translocation (X;19)(q13;13.3), which has not been reported in small round cell tumors of childhood or adults. The final diagnosis rendered was an undifferentiated small round cell tumor of uncertain cell of origin.
authors.affiliation: Department of Pediatrics, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas, USA. yustein@bcm.edu
authors.forename: Jason T
authors.initials: JT
authors.lastname: Yustein
authors.forename: Surya
authors.initials: S
authors.lastname: Rednam
authors.forename: Alison A
authors.initials: AA
authors.lastname: Bertuch
authors.forename: John A
authors.initials: JA
authors.lastname: Goss
authors.forename: Mary L
authors.initials: ML
authors.lastname: Brandt
authors.forename: Karen
authors.initials: K
authors.lastname: Eldin
authors.forename: Xinyan
authors.initials: X
authors.lastname: Lu
authors.forename: John
authors.initials: J
authors.lastname: Hicks
mesh_terms: D000008:Abdominal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D018288:Carcinoma, Small Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D002648:Child; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics*; D041321:Chromosomes, Human, X / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014178:Translocation, Genetic