title: Two new compounds from the broth of the marine fungus Penicillium griseofulvum Y19-07.
abstract: Two new compounds, 4-hydroxyphenethyl methyl succinate (1) and 4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate (2), were isolated from the EtOAc extract of the broth of the marine fungus Penicillium griseofulvum Y19-07. Five known compounds were also obtained in this study. The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and mass spectrometry. All of the isolates were evaluated for their scavenging properties toward the 2,2-diphenyl-1-picrylhydrazyl free radical by spectroscopic assays. Also, in the cytotoxicity assay of the two new compounds against HL-60 and PC-3 prostate cancer cell lines, compound 2 showed potential activity with an IC(50) value of 64.5 microM against human HL-60 cancer cells.
authors.affiliation: School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Wang
authors.forename: Li
authors.initials: L
authors.lastname: Tian
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Hua
authors.forename: Xuan
authors.initials: X
authors.lastname: Lu
authors.forename: Sha
authors.initials: S
authors.lastname: Sun
authors.forename: Hong-Hua
authors.initials: HH
authors.lastname: Wu
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Pei
mesh_terms: D000085:Acetates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D008297:Male; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000737:chemistry*; D010648:Phenylacetates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010851:Picrates / Q000494:pharmacology; D043982:Rhizophoraceae / Q000382:microbiology; D013386:Succinates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C547994:4-hydroxyphenethyl 2-(4-hydroxyphenyl)acetate; C547993:4-hydroxyphenethyl methyl succinate; D000085:Acetates; D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010648:Phenylacetates; D010851:Picrates; D013386:Succinates; C004931:1,1-diphenyl-2-picrylhydrazyl