Ki-67 and Bcl-2 antigen expression in adenomatous colorectal polyps from women with breast cancer.
BACKGROUND
The aim of this study was to evaluate Ki-67 and Bcl-2 antigen expression in colorectal polyps from women with breast cancer.


METHODS
A randomized, controlled study was carried out in 35 women, either with or without breast cancer, who had adenomatous colorectal polyps. The patients were divided into two groups: group A (without breast cancer; control group; n = 17) and group B (with breast cancer; study group; n = 18). Immunohistochemistry was performed on the colorectal polyps to evaluate Ki-67 and Bcl-2 antigen expression. Student's t-test and the chi(2) test were used for the statistical analysis of Ki-67 and Bcl-2 expression, respectively. Statistical significance was established as P < 0.05.


RESULTS
The mean percentage of Ki-67-stained nuclei in groups A and B was 36.25 +/- 2.31 and 59.44 +/- 3.34 (+/- SEM), respectively (P < 0.0001), while the percentage of cases with cells expressing Bcl-2 in groups A and B was 23.5 and 77.8%, respectively (P < 0.001).


CONCLUSIONS
In the present study, there was greater proliferative activity and greater expression of the antiapoptotic protein Bcl-2 in the colorectal polyps of women with breast cancer.
de Sousa-Júnior
Edílson Carvalho
EC
Department of General Surgery, Hospital Getulio Vargas, Federal University of Piauí, Teresina, Piauí, Brazil.
Alencar
Airlane Pereira
AP
da Silva
Benedito Borges
BB
D011125:Adenomatous Polyposis Coli / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D016022:Case-Control Studies; D003106:Colon / Q000378:metabolism*; D003113:Colonoscopy; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen / Q000378:metabolism*; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D012007:Rectum / Q000378:metabolism*; D015996:Survival Rate; D016896:Treatment Outcome
D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2