title: Effect of PTSD diagnosis and contingency management procedures on cocaine use in dually cocaine- and opioid-dependent individuals maintained on LAAM: a retrospective analysis.
abstract: This randomized clinical trial retrospectively examined the effect of post-traumatic stress disorder (PTSD) and contingency management (CM) on cocaine use in opioid and cocaine dependent individuals maintained on high or low-dose LAAM randomly assigned to CM or a yoked-control condition. Cocaine-positive urines decreased more rapidly over time in those without PTSD versus those with PTSD in the noncontingency condition. In participants with PTSD, CM resulted in fewer cocaine-positive urines compared to the noncontingent condition. This suggests that CM may help improve the potentially worse outcomes in opioid- and cocaine-dependent individuals with PTSD compared to those without PTSD. (Am J Addict 2010;00:1-9).
authors.affiliation: Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. mjmancino@uams.edu
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Mancino
authors.forename: Janette
authors.initials: J
authors.lastname: McGaugh
authors.forename: Zachary
authors.initials: Z
authors.lastname: Feldman
authors.forename: James
authors.initials: J
authors.lastname: Poling
authors.forename: Alison
authors.initials: A
authors.lastname: Oliveto
mesh_terms: D000328:Adult; D001521:Behavior Therapy / Q000379:methods*; D019970:Cocaine-Related Disorders / Q000150:complications / Q000188:drug therapy* / Q000628:therapy* / Q000652:urine; D003131:Combined Modality Therapy / Q000523:psychology; D017831:Diagnosis, Dual (Psychiatry) / Q000706:statistics & numerical data; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008692:Methadyl Acetate / Q000008:administration & dosage*; D009293:Opioid-Related Disorders / Q000150:complications / Q000188:drug therapy* / Q000628:therapy*; D010349:Patient Compliance / Q000706:statistics & numerical data; D012189:Retrospective Studies; D013313:Stress Disorders, Post-Traumatic / Q000150:complications / Q000188:drug therapy* / Q000628:therapy*
chemical_list: D008692:Methadyl Acetate