title: Fluvastatin increases tyrosinase synthesis induced by UVB irradiation of B16F10 melanoma cells.
abstract: Statins are widely used to lower plasma concentrations of lipids, e.g. cholesterol. One of the main effects of statin treatment is inhibition of hydroxymethyl glutaryl-coenzyme A reductase. The role of fluvastatin, a frequently used statin, was examined in potential modulation of tyrosinase (key enzyme of melanogenesis) synthesis. Levels of tyrosinase mRNA induced by UVB irradiation of B16F10 melanoma cell line were measured by real time PCR. Fluvastatin increases tyrosinase mRNA production induced by UVB irradiation in B16F10 melanoma cell line. Fluvastatin treatment may potentially influence melanin synthesis and protection against UV irradiation.
authors.affiliation: Department of Histology and Embryology, Center for Biostructure, Medical University of Warsaw, Warsaw, Poland. rgalus@ib.amwaw.edu.pl
authors.forename: Ryszard
authors.initials: R
authors.lastname: Galus
authors.forename: Emir
authors.initials: E
authors.lastname: Sajjad
authors.forename: Justyna
authors.initials: J
authors.lastname: Niderla
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Borowska
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Włodarski
authors.forename: Paweł
authors.initials: P
authors.lastname: Włodarski
authors.forename: Jarosław
authors.initials: J
authors.lastname: Jóźwiak
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004790:Enzyme Induction / Q000528:radiation effects; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry / Q000494:pharmacology*; D000077340:Fluvastatin; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D008546:Melanoma, Experimental / Q000201:enzymology / Q000235:genetics*; D051379:Mice; D014442:Monophenol Monooxygenase / Q000096:biosynthesis / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014466:Ultraviolet Rays
chemical_list: D005229:Fatty Acids, Monounsaturated; D007211:Indoles; D012333:RNA, Messenger; D000077340:Fluvastatin; D014442:Monophenol Monooxygenase