title: Guidelines for preclinical animal research in ALS/MND: A consensus meeting.
abstract: The development of therapeutics for ALS/MND is largely based on work in experimental animals carrying human SOD mutations. However, translation of apparent therapeutic successes from in vivo to the human disease has proven difficult and a considerable amount of financial resources has been apparently wasted. Standard operating procedures (SOPs) for preclinical animal research in ALS/MND are urgently required. Such SOPs will help to establish SOPs for translational research for other neurological diseases within the next few years. To identify the challenges and to improve the research methodology, the European ALS/MND group held a meeting in 2006 and published guidelines in 2007 (1). A second international conference to improve the guidelines was held in 2009. These second and improved guidelines are dedicated to the memory of Sean F. Scott.
authors.affiliation: Department of Neurology, University of Ulm, Germany. albert.ludolph@rku.de <albert.ludolph@rku.de>
authors.forename: Albert C
authors.initials: AC
authors.lastname: Ludolph
authors.forename: Caterina
authors.initials: C
authors.lastname: Bendotti
authors.forename: Eran
authors.initials: E
authors.lastname: Blaugrund
authors.forename: Adriano
authors.initials: A
authors.lastname: Chio
authors.forename: Linda
authors.initials: L
authors.lastname: Greensmith
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Loeffler
authors.forename: Richard
authors.initials: R
authors.lastname: Mead
authors.forename: Heiko G
authors.initials: HG
authors.lastname: Niessen
authors.forename: Susanne
authors.initials: S
authors.lastname: Petri
authors.forename: Pierre-Francois
authors.initials: PF
authors.lastname: Pradat
authors.forename: Wim
authors.initials: W
authors.lastname: Robberecht
authors.forename: Markus
authors.initials: M
authors.lastname: Ruegg
authors.forename: Birgit
authors.initials: B
authors.lastname: Schwalenstöcker
authors.forename: Detlev
authors.initials: D
authors.lastname: Stiller
authors.forename: Leonard
authors.initials: L
authors.lastname: van den Berg
authors.forename: Fernando
authors.initials: F
authors.lastname: Vieira
authors.forename: Stephan
authors.initials: S
authors.lastname: von Horsten
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000188:drug therapy*; D000818:Animals; D032921:Consensus; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods* / Q000592:standards*; D017408:Guidelines as Topic