title: Femtomolar detection of 2,4-dichlorophenoxyacetic acid herbicides via competitive immunoassays using microfluidic based carbon nanotube liquid gated transistor.
abstract: Monitoring of environmental pollutants has become increasingly important due to concern over potential health and environmental impact inflicted by these chemicals. In this contribution, we focus on the development of an all-plastic biosensor comprising laminated single-walled carbon nanotubes as the active element and its conductance modulation in a liquid-gated field effect transistor, as the principle of transduction, for the detection of 2,4-dicholorophenoxy acetic acid (2,4-D) herbicide. The reported biosensor is capable of performing real-time label-free detection of analytes in liquid environment. This biosensor which relies on immunoassay principle for specificity is able to detect down to 500 fM levels of 2,4-D in soil samples.
authors.affiliation: School of Material Science & Engineering, Nanyang Technological University, Singapore, 639798, Singapore.
authors.forename: I Putu Mahendra
authors.initials: IP
authors.lastname: Wijaya
authors.forename: Tey Ju
authors.initials: TJ
authors.lastname: Nie
authors.forename: Sonu
authors.initials: S
authors.lastname: Gandhi
authors.forename: Robin
authors.initials: R
authors.lastname: Boro
authors.forename: Alagappan
authors.initials: A
authors.lastname: Palaniappan
authors.forename: Goh Wei
authors.initials: GW
authors.lastname: Hau
authors.forename: Isabel
authors.initials: I
authors.lastname: Rodriguez
authors.forename: C Raman
authors.initials: CR
authors.lastname: Suri
authors.forename: Subodh G
authors.initials: SG
authors.lastname: Mhaisalkar
mesh_terms: D015084:2,4-Dichlorophenoxyacetic Acid / Q000032:analysis*; D004784:Environmental Monitoring / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006540:Herbicides / Q000032:analysis*; D007118:Immunoassay / Q000295:instrumentation*; D008832:Microchemistry / Q000295:instrumentation; D044085:Microfluidics / Q000295:instrumentation*; D036103:Nanotechnology / Q000295:instrumentation; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012989:Soil Pollutants / Q000032:analysis*; D012996:Solutions / Q000737:chemistry; D014173:Transistors, Electronic
chemical_list: D006540:Herbicides; D037742:Nanotubes, Carbon; D012989:Soil Pollutants; D012996:Solutions; D015084:2,4-Dichlorophenoxyacetic Acid