title: Markers of oxidative damage are not elevated in otherwise healthy individuals with the metabolic syndrome.
abstract: OBJECTIVE
  The role of oxidative damage in the pathogenesis of metabolic syndrome is poorly understood.
  
  
  METHODS
  A detailed cross-sectional study was performed to assess the relationship between lipid oxidation products, gamma-glutamyltransferase, high-sensitivity C-reactive protein (hs-CRP), and phospholipase activities with respect to the metabolic status in a cohort of otherwise healthy individuals.
  
  
  RESULTS
  A total of 179 individuals (87 men and 92 women) aged 43 +/- 14 years (mean +/- SD) participated in this study. There were no differences in the levels of plasma F(2)-isoprostanes, hydroxyeicosatetraenoic acids, cholesterol oxidation products, and phospholipase activities in individuals with features of metabolic syndrome. In multivariate analyses, serum hs-CRP was a consistent independent predictor of metabolic syndrome.
  
  
  CONCLUSIONS
  Minimal changes were observed in multiple markers of oxidative damage in a well-characterized cohort of individuals with features of metabolic syndrome.
authors.affiliation: Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. raymond_seet@nus.edu.sg
authors.forename: Raymond C-S
authors.initials: RC
authors.lastname: Seet
authors.forename: Chung-Yung J
authors.initials: CY
authors.lastname: Lee
authors.forename: Erle C H
authors.initials: EC
authors.lastname: Lim
authors.forename: Amy M L
authors.initials: AM
authors.lastname: Quek
authors.forename: Shan-Hong
authors.initials: SH
authors.lastname: Huang
authors.forename: Chin-Meng
authors.initials: CM
authors.lastname: Khoo
authors.forename: Barry
authors.initials: B
authors.lastname: Halliwell
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000378:metabolism*; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D054467:Phospholipases A2 / Q000097:blood; D011237:Predictive Value of Tests; D005723:gamma-Glutamyltransferase / Q000097:blood
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein; D005723:gamma-Glutamyltransferase; D054467:Phospholipases A2