title: Evaluation of Chlorofusin, its Seven Chromophore Diastereomers, and Key Analogues.
abstract: Chlorofusin, its seven chromophore diastereomers, and key analogues were comparatively examined for inhibition of MDM2-p53 binding revealing that the chromophore, but not simple replacements, contributes significantly to the natural products properties, and that this contribution is independent of its relative and absolute stereochemistry.
authors.affiliation: Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Ryan C
authors.initials: RC
authors.lastname: Clark
authors.forename: Sang Yeul
authors.initials: SY
authors.lastname: Lee
authors.forename: Inkyu
authors.initials: I
authors.lastname: Hwang
authors.forename: Mark
authors.initials: M
authors.lastname: Searcey
authors.forename: Dale L
authors.initials: DL
authors.lastname: Boger