title: Amplification of epidermal growth factor receptor gene in renal cell carcinoma.
abstract: Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC.
authors.affiliation: Oncology Business Unit, GlaxoSmithKline, London UB11 1BT, United Kingdom.
authors.forename: Iman
authors.initials: I
authors.lastname: El-Hariry
authors.forename: Thomas
authors.initials: T
authors.lastname: Powles
authors.forename: Mike R
authors.initials: MR
authors.lastname: Lau
authors.forename: Cora N
authors.initials: CN
authors.lastname: Sternberg
authors.forename: Alain
authors.initials: A
authors.lastname: Ravaud
authors.forename: Hans
authors.initials: H
authors.lastname: von der Maase
authors.forename: Niko
authors.initials: N
authors.lastname: Zantl
authors.forename: Peter
authors.initials: P
authors.lastname: Harper
authors.forename: Frédéric
authors.initials: F
authors.lastname: Rolland
authors.forename: Bruno
authors.initials: B
authors.lastname: Audhuy
authors.forename: Friederike
authors.initials: F
authors.lastname: Barthel
authors.forename: Jean-Pascal
authors.initials: JP
authors.lastname: Machiels
authors.forename: Pina
authors.initials: P
authors.lastname: Patel
authors.forename: Ernst-Dietrick
authors.initials: ED
authors.lastname: Kreuser
authors.forename: Robert E
authors.initials: RE
authors.lastname: Hawkins
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000378:metabolism; D066246:ErbB Receptors / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007680:Kidney Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis
chemical_list: D066246:ErbB Receptors