title: Determination of adrenolytic drugs by SPME-LC-MS.
abstract: Five adrenolytic drugs have been analyzed by liquid chromatography-mass spectrometry (LC-MS). Samples were prepared by solid-phase microextraction (SPME) using polypyrrole fibers coated on stainless steel support as an adsorbent for the drugs. Adsorption efficiencies were 95% and were close for all the drugs investigated. Relative standard deviations (RSD), calculated for samples prepared in standard solutions, were in the range 2.5-13%, however RSD values for the drugs in human plasma were 2.5-4.5%. Using LC-MS the limit of detection (LOD) and the limit of quantification (LOQ) were in the ranges 0.11-0.18 and 0.39-0.54 ng mL(-1), respectively, for the five drugs.
authors.affiliation: Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100, Torun, Poland. bbusz@chem.uni.torun.pl.
authors.forename: Boguslaw
authors.initials: B
authors.lastname: Buszewski
authors.affiliation: Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100, Torun, Poland.
authors.forename: Pawel
authors.initials: P
authors.lastname: Olszowy
authors.affiliation: Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100, Torun, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Ligor
authors.affiliation: Department of Environmental Chemistry and Bioanalytics, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100, Torun, Poland.
authors.forename: Malgorzata
authors.initials: M
authors.lastname: Szultka
authors.affiliation: Department of Physical Chemistry and Physicochemistry of Polymers, Faculty of Chemistry, Nicolaus Copernicus University, Gagarin 7, 87-100, Torun, Poland.
authors.forename: Jacek
authors.initials: J
authors.lastname: Nowaczyk
authors.affiliation: Department of Surgery, Collegium Medicum, Nicolaus Copernicus University, St. Joseph Street 53-59, 85-067, Bydgoszcz, Poland.
authors.forename: Maciej
authors.initials: M
authors.lastname: Jaworski
authors.affiliation: Department of Surgery, Collegium Medicum, Nicolaus Copernicus University, St. Joseph Street 53-59, 85-067, Bydgoszcz, Poland.
authors.forename: Marek
authors.initials: M
authors.lastname: Jackowski
mesh_terms: D018674:Adrenergic Antagonists / Q000097:blood*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D057230:Limit of Detection; D052617:Solid Phase Microextraction / Q000379:methods*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*
chemical_list: D018674:Adrenergic Antagonists