title: [Vogt-Koyanagi-Harada disease associated with interferon-alpha and ribavirin therapy for chronic hepatitis C infection].
abstract: The complex immunological effects of interferon and ribavirin therapy in hepatitis C virus may also exacerbate or trigger the development of autoimmunity. A rare case of Vogt-Koyanagi-Harada disease associated with ribavirin and interferon-alpha treatment for chronic hepatitis C infection is presented. The potential role of interferon and/or ribavirin therapy is discussed. Physicians should be aware of the association between interferon-alpha 2a and ribavirin use for hepatitis C infection and the development of Harada disease. This severe ophthalmological complication requires close follow-up of hepatitis C virus-infected patients on interferon-alpha treatment.
authors.affiliation: Service B, Institut Hédi Rais d'ophtalmologie, Tunis, Tunisie. chebilahmed@yahoo.fr <chebilahmed@yahoo.fr>
authors.forename: A
authors.initials: A
authors.lastname: Chebil
authors.forename: F
authors.initials: F
authors.lastname: Kort
authors.forename: R
authors.initials: R
authors.lastname: Bouraoui
authors.forename: N Ben
authors.initials: NB
authors.lastname: Youssef
authors.forename: L
authors.initials: L
authors.lastname: El Matri
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D019698:Hepatitis C, Chronic / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D011994:Recombinant Proteins; D012254:Ribavirin / Q000008:administration & dosage / Q000009:adverse effects*; D014331:Tropicamide / Q000008:administration & dosage / Q000627:therapeutic use; D014607:Uveomeningoencephalitic Syndrome / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D000305:Adrenal Cortex Hormones; D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D012254:Ribavirin; D014331:Tropicamide; D008775:Methylprednisolone