title: Platelet monoamine oxidase activity predicts alcohol sensitivity and voluntary alcohol intake in rhesus monkeys.
abstract: Platelet monoamine oxidase B (MAO-B) has been proposed to be a biological marker for the properties of monoamine systems, with low activity being associated with vulnerability for high scores on personality traits such as sensation seeking, monotony avoidance, and impulsiveness, as well as for vulnerability for alcoholism. In the present study, platelet MAO-B activity was analysed in 78 rhesus macaques, and its relation to voluntary alcohol intake and behaviours after intravenous alcohol administration was observed. Monkeys with low platelet MAO-B activity had low levels of 5-hydroxyindole acetic acid in cerebrospinal fluid and showed excessive aggression after alcohol administration. A novel finding was that animals with low platelet MAO-B activity showed less intoxication following alcohol administration. As we have shown previously, they also voluntarily consumed more alcohol. We here replicate results from studies on both humans and non-human primates, showing the utility of platelet MAO as a marker for risk behaviours and alcohol abuse. Furthermore, we link platelet MAO activity to alcohol sensitivity.
authors.affiliation: Department of Neuroscience, Uppsala University, Uppsala, Sweden. hanna-linn.wargelius@neuro.uu.se
authors.forename: Hanna-Linn
authors.initials: HL
authors.lastname: Wargelius
authors.forename: Claudia
authors.initials: C
authors.lastname: Fahlke
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Suomi
authors.forename: Lars
authors.initials: L
authors.lastname: Oreland
authors.forename: James Dee
authors.initials: JD
authors.lastname: Higley
mesh_terms: D000374:Aggression; D000428:Alcohol Drinking; D000437:Alcoholism / Q000097:blood*; D000818:Animals; D001522:Behavior, Animal; D000431:Ethanol / Q000008:administration & dosage; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008253:Macaca mulatta; D008297:Male; D015233:Models, Statistical; D008995:Monoamine Oxidase / Q000097:blood*; D012307:Risk Factors
chemical_list: D000431:Ethanol; D006897:Hydroxyindoleacetic Acid; D008995:Monoamine Oxidase