Hyaluronidase inhibitors from Takuran, Lycopus lucidus.
Takuran is a traditional herbal medicine that is produced from the herbal plant Lycopus lucidas TURCZ. (Lamiaceae). Takuran is used as a treatment for diseases in women. From Takuran, four new phenylpropanoids along with 18 known compounds were isolated, and their structures were elucidated by spectroscopic analyses. Five phenylpropanoids isolated from the plant showed hyaluronidase inhibitory activity comparable to that of rosmarinic acid.
Murata
Toshihiro
T
Department of Pharmacognosy, Tohoku Pharmaceutical University, Sendai 981-8558,Japan. murata-t@tohoku-pharm.ac.jp
Watahiki
Mai
M
Tanaka
Yu
Y
Miyase
Toshio
T
Yoshizaki
Fumihiko
F
D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D053630:Depsides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D019686:Lamiaceae / Q000737:chemistry*; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013045:Species Specificity; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D000097123:Rosmarinic Acid
D002934:Cinnamates; D053630:Depsides; D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors; D006821:Hyaluronoglucosaminidase; D010636:Phenols; D000097123:Rosmarinic Acid