Association between TGFB3 and nonsyndromic cleft lip with or without cleft palate in a Chilean population.
OBJECTIVE
To assess the possible association between TGFB3 allele variants and nonsyndromic cleft lip with or without cleft palate in a Chilean population.


METHODS
In our study we used a case-parents trios design. The sample consisted of 150 unrelated trios ascertained through probands affected with nonsyndromic cleft lip with or without cleft palate. Three TGFB3 polymorphisms were analyzed (rs2268626, rs2268625, and rs3917201). An allele/haplotype transmission disequilibrium test was used to evaluate the possible genotype-phenotype association.


RESULTS
An overtransmission from parents to affected progeny was observed for the A allele of rs3917201 (p = .03) and for the rs2268625-rs3917201 A-A haplotype (p = .022). A defect of transmission of rs2268625-rs3917201 G-G haplotype (p = .022) was observed also.


CONCLUSIONS
Allelic and haplotypic associations implicate a possible role of TGFB3 in nonsyndromic cleft lip with or without cleft palate in the Chilean population. Additional studies are needed in order to elucidate the possible mechanisms that can explain the role of TGFB3 genetic variants in the condition.
Suazo
José
J
Biomedical Sciences Institute, School of Medicine, University of Chile, Santiago, Chile.
Santos
José Luis
JL
Scapoli
Luca
L
Jara
Lilian
L
Blanco
Rafael
R
D000225:Adenine; D000483:Alleles; D016022:Case-Control Studies; D002677:Chile; D002971:Cleft Lip / Q000235:genetics*; D002972:Cleft Palate / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006147:Guanine; D006239:Haplotypes / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D053782:Transforming Growth Factor beta3 / Q000235:genetics*
C509044:TGFB3 protein, human; D053782:Transforming Growth Factor beta3; D006147:Guanine; D000225:Adenine