Catalytic enantioselective conjugate additions with α,β-unsaturated sulfones.
We describe the development of a highly efficient catalytic asymmetric conjugate addition to α,β-unsaturated sulfones. Utilizing practical bifunctional organic catalysts and involving air- and moisture-tolerant conditions, conjugate additions of a wide range of Michael donors to α,β-unsaturated sulfones proceeded in excellent enantioselectivity/diastereoselectivity and high yield. This efficient and operationally simple new catalytic asymmetric reaction should provide a versatile approach for the asymmetric synthesis of chiral sulfones bearing all-carbon quaternary stereocenters.
Li
Hongming
H
Department of Chemistry, Brandeis University, Waltham, Massachuesttes, 02454-9110, USA.
Song
Jun
J
Deng
Li
L