title: SAPHO syndrome with adrenal deficiency: a case report.
abstract: BACKGROUND
  The SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, osteomyelitis) is a rare painful disorder, usually with a good long-term prognosis. Its etiology remains unclear, and various treatment regimens frequently fail to control the disease.
  
  
  METHODS
  A 46-year-old Caucasian female was referred for anterior chest wall and back pain. Physical examination was unremarkable except for skin lesions noted on soles of both feet, extremities and the face. A thoracic magnetic resonance imaging study demonstrated a lesion characterized with bone marrow edema and proliferation of soft tissue in the sternum. A brain MRI was requested secondary to the elevated prolactin level which was compatible with empty sella syndrome.
  
  
  CONCLUSIONS
  The case presented here has the unique feature of adrenal deficiency presenting alongside the SAPHO syndrome and is presented as the first case reported. This syndrome could become complicated with different organ system involvement other than bone and skin. There is a need further studies that will explore the weak relationship between SAPHO syndrome and adrenal deficiency.
authors.affiliation: Physical Therapy and Rehabilitation Department, Ege University Faculty of Medicine, 35100 Bornova, Izmir, Turkey. eyigor@hotmail.com
authors.forename: Sibel
authors.initials: S
authors.lastname: Eyigör
authors.forename: Hale
authors.initials: H
authors.lastname: Karapolat
authors.forename: Hilal
authors.initials: H
authors.lastname: Adanur
authors.forename: Yeşim
authors.initials: Y
authors.lastname: Kirazli