Zwittermicin A: synthesis of analogs and structure-activity studies.
Analogs and diastereomers of the natural product zwittermicin A were prepared. SAR studies of these compounds reveal the antifungal activity to be dependent singularly upon the natural constitution and configuration.
Rogers
Evan W
EW
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, United States.
Dalisay
Doralyn S
DS
Molinski
Tadeusz F
TF
D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology*; D001409:Bacillus cereus / Q000737:chemistry; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D010455:Peptides; C088290:zwittermicin A