Two new prenylated xanthones and a new prenylated tetrahydroxanthone from the pericarp of Garcinia mangostana.
Two new prenylated xanthones and a new prenylated tetrahydroxanthone, garcimangosxanthone A-C (1-3), along with fourteen known xanthones were isolated from the pericarp of Garcinia mangostana. Their structures were elucidated on the basis of spectroscopic data. Compounds 1 and 2 exhibited in vitro cytotoxicity against A549, LAC and A375 cell lines with IC(50) values of 5.7-24.9 microM, which were comparable to those of doxorubicin.
Zhang
Yaozheng
Y
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, PR China.
Song
Zhijun
Z
Hao
Jing
J
Qiu
Shengxiang
S
Xu
Zhifang
Z
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D029762:Garcinia mangostana / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification*
D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes; D044004:Xanthones