Copper-catalyzed guanidinylation of aryl iodides: the formation of N,N'-disubstituted guanidines.
A copper-catalyzed cross-coupling reaction of guanidine nitrate with aryl iodides was used for the formation of N,N'-disubstituted guanidines to be used as potential therapeutics for strokes. A relatively inexpensive commercially available guanidine salt and a series of aryl iodides together with copper iodide and N,N-diethylsalicylamide as an efficient catalyst/ligand system provided a simple diarylation procedure.
Cortes-Salva
Michelle
M
Department of Chemistry, University of South Florida, 4202 East Fowler Avenue CHE 205A, Tampa, Florida 33620, USA.
Nguyen
Be-Lan
BL
Cuevas
Javier
J
Pennypacker
Keith R
KR
Antilla
Jon C
JC
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D006146:Guanidines; D006847:Hydrocarbons, Iodinated; D003300:Copper