title: Evaluation of pathologists (histopathology) and radiologists (cone beam computed tomography) differentiating radicular cysts from granulomas.
abstract: BACKGROUND
  This study investigated the differentiation of radicular cysts from granulomas. Cone beam computed tomography (CBCT) imaging was compared with the existing standard, biopsy and histopathology.
  
  
  METHODS
  Forty-five patients scheduled for an apicoectomy received a CBCT scan of the involved arch. Two oral and maxillofacial radiologists, working independently and using the same criteria, categorized the CBCT images as one of the following: cyst, likely cyst, likely granuloma, granuloma, or other. After apicoectomies, two oral pathologists, working independently and using the same criteria, diagnosed the surgical specimens as one of the following: radicular cyst, granuloma, or other. We examined the following: (1) interrater agreement between pathologists as to the biopsy diagnosis, (2) interrater agreement between radiologists as to the CBCT diagnosis, and (3) accuracy of radiologists' diagnostic assessments using histopathology as the standard.
  
  
  RESULTS
  Findings showed strong interrater reliability between pathologists (kappa=0.79, z=5.46, p<0.0001) and weak interrater reliability between radiologists (kappa=0.14, p=not significant). Accuracy (true-positives plus true-negatives) for the two radiologists was 51% and 63%.
  
  
  CONCLUSIONS
  Under the conditions of this study, based on the inconsistency of the radiologists' reports as evidenced by statistical analyses, it was concluded that CBCT imaging is not a reliable diagnostic method for differentiating radicular cysts from granulomas. Surgical biopsy and histopathological evaluation remain the standard procedure for differentiating radicular cysts from granulomas.
authors.affiliation: Department of Endodontics, New York University College of Dentistry, New York, NY 10010-4086, USA. par1@nyu.edu
authors.forename: Paul A
authors.initials: PA
authors.lastname: Rosenberg
authors.forename: Jared
authors.initials: J
authors.lastname: Frisbie
authors.forename: Jaehoon
authors.initials: J
authors.lastname: Lee
authors.forename: Kyung
authors.initials: K
authors.lastname: Lee
authors.forename: Herbert
authors.initials: H
authors.lastname: Frommer
authors.forename: Shailesh
authors.initials: S
authors.lastname: Kottal
authors.forename: Joan
authors.initials: J
authors.lastname: Phelan
authors.forename: Louis
authors.initials: L
authors.lastname: Lin
authors.forename: Gene
authors.initials: G
authors.lastname: Fisch
mesh_terms: D001047:Apicoectomy; D001706:Biopsy; D002983:Clinical Competence / Q000706:statistics & numerical data; D054893:Cone-Beam Computed Tomography / Q000379:methods*; D003937:Diagnosis, Differential; D006099:Granuloma / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D015588:Observer Variation; D010336:Pathology / Q000706:statistics & numerical data; D011842:Radicular Cyst / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D019252:Radiography, Dental, Digital / Q000295:instrumentation; D011871:Radiology / Q000379:methods / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity