title: Epstein-Barr virus-associated primary central nervous system lymphoma in the Japanese population.
abstract: The incidence of Epstein-Barr virus (EBV)-associated primary central nervous system (CNS) lymphoma in Japan was assessed using in situ hybridization of EBV-encoded small ribonucleic acid-1 (EBER-1) to identify the presence of EBV in 22 cases of formalin-fixed and paraffin-embedded primary CNS lymphoma. All cases were B-cell lymphoma. EBER-1 expression was observed in the nuclei of 3 of 22 primary CNS lymphoma cases (13.6%). The incidence of EBV-positive lymphoma in Japanese cases is higher than previously reported from Western countries. Patients with EBV-positive primary CNS lymphoma showed shorter survival than those with negative tumors (median 4 months vs. 26 months). EBER-1 in situ hybridization for the detection of EBV infection is rapid and reliable. Infrequent association suggests a different pathogenetic mechanism in the evolution of these tumors. Geographical differences in the incidence of EBV-associated primary CNS lymphoma may reflect epidemiological factors.
authors.affiliation: Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Fukui. kitai@u-fukui.ac.jp
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Kitai
authors.forename: Ken
authors.initials: K
authors.lastname: Matsuda
authors.forename: Erika
authors.initials: E
authors.lastname: Adachi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Saito
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Nakajima
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Sato
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Imamura
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kubota
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics; D001921:Brain / Q000473:pathology / Q000821:virology; D016543:Central Nervous System Neoplasms / Q000401:mortality* / Q000473:pathology / Q000821:virology*; D015897:Comorbidity; D020031:Epstein-Barr Virus Infections / Q000453:epidemiology*; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000378:metabolism; D006801:Humans; D016867:Immunocompromised Host / Q000502:physiology; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008223:Lymphoma / Q000401:mortality* / Q000473:pathology / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D015996:Survival Rate / Q000639:trends
chemical_list: D014408:Biomarkers, Tumor; C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral