title: Synthesis of a quinolone library from ynones.
abstract: A library of 72 quinolones was synthesized from substituted anthranilic acids, using ynone intermediates. These masked β-dicarbonyl synthons allowed cyclization under milder conditions than previously reported quinolone syntheses.
authors.affiliation: Department of Medicinal Chemistry and Center for Methodology and Library Development, University of Kansas, 1251 Wescoe Hall Drive, Lawrence Kansas 66045, USA; Department of Medicinal Chemistry and the Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55414, USA.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Ward
authors.forename: Brandon J
authors.initials: BJ
authors.lastname: Turunen
authors.forename: Torsten
authors.initials: T
authors.lastname: Haack
authors.forename: Benjamin
authors.initials: B
authors.lastname: Neuenswander
authors.forename: William
authors.initials: W
authors.lastname: Shadrick
authors.forename: Gunda I
authors.initials: GI
authors.lastname: Georg