title: Radioguided occult lesion localization (ROLL) for non-palpable breast cancer: a comparison between day-before and same-day protocols.
abstract: BACKGROUND
  Although radioguided occult lesion localization (ROLL) has become a widely accepted technique, the optimal time interval between the radioisotope injection and surgery has not yet been determined.
  
  
  OBJECTIVE
  To delineate the effects of time from the injection of the radionuclide until surgery on the ROLL success rate in a patient population diagnosed as having non-palpable breast cancer.
  
  
  METHODS
  Between December 2004 and May 2009, 75 patients underwent ROLL procedure. The day-before protocol and same-day protocols included 50 and 25 breast cancer patients respectively.
  
  
  RESULTS
  The two study groups were comparable in terms of age, localization technique, radiological findings and the type of surgical procedures (P > 0.05). No statistically significant difference was noticed in the pathological diagnosis, cancer size and the surgical margin clearance between the two groups (P > 0.05).
  
  
  CONCLUSIONS
  Same-day injection of the radiotracer was not superior to the day-before injection in ROLL. The day-before protocol can be scheduled for the convenience of both patients and hospital staff.
authors.affiliation: Istanbul University, Cerrahpasa Medical School, Department of General Surgery, Istanbul, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Aydogan
authors.forename: Volkan
authors.initials: V
authors.lastname: Ozben
authors.forename: Varol
authors.initials: V
authors.lastname: Celik
authors.forename: Cihan
authors.initials: C
authors.lastname: Uras
authors.forename: Gülgün
authors.initials: G
authors.lastname: Tahan
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Gazioglu
authors.forename: Ali
authors.initials: A
authors.lastname: Cengiz
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ferahman
authors.forename: Ali
authors.initials: A
authors.lastname: Cercel
authors.forename: Mehmet Halit
authors.initials: MH
authors.lastname: Yilmaz
authors.forename: Metin
authors.initials: M
authors.lastname: Halac
authors.forename: Hilal
authors.initials: H
authors.lastname: Unal
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D015331:Cohort Studies; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D012189:Retrospective Studies; D025321:Surgery, Computer-Assisted; D013668:Technetium Tc 99m Aggregated Albumin / Q000008:administration & dosage
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin