Pregnancy and delivery outcomes of HIV infected women in Switzerland 2003-2008.
Rates of vertical HIV transmission between mother and child are low, allowing many HIV positive women to have children with near impunity. In this study, data from the Swiss Mother and Child HIV Cohort Study were used to describe maternal characteristics and their association with pregnancy outcomes in HIV positive women.



HIV positive women were followed prospectively during their pregnancies and deliveries by anonymous questionnaires between January 2003 and October 2008. Adverse pregnancy outcomes included preterm delivery, preeclampsia and gestational diabetes mellitus.



This study included 266 HIV positive women, of which 67 (25.2%) were first diagnosed with HIV during pregnancy. Thirty percent (n=80) of the women had pregnancy complications after 24 weeks of gestation. Preterm delivery was noted in 72 (27%) patients. Other complications included preeclampsia (n=7; 2.6%) and gestational diabetes (n=7; 2.6%). Older maternal age was the only risk factor associated with adverse pregnancy outcomes (adjusted odds ratio: 1.06, 95% confidence interval 1.01-1.12, P=0.02).



HIV positive women, especially with advanced maternal age, have high-risk pregnancies and should be monitored as in an interdisciplinary setting. The preponderance of initial HIV diagnosis during pregnancy confirms the importance of HIV screening in pregnant women.
Aebi-Popp
Karoline
K
Division of Obstetrics and Gynaecology, University Hospital Basel, Switzerland. kaebi@uhbs.ch
Lapaire
Olav
O
Glass
Tracy R
TR
Vilén
Louise
L
Rudin
Christoph
C
Elzi
Luigia
L
Battegay
Mannel
M
Keiser
Olivia
O
de Tejada
Begona Martinez
BM
Hoesli
Irene M
IM
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000209:etiology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000635:transmission; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D008423:Maternal Age; D011225:Pre-Eclampsia / Q000209:etiology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000209:etiology; D011446:Prospective Studies; D012307:Risk Factors; D013557:Switzerland