Subgenual cingulate theta activity predicts treatment response of repetitive transcranial magnetic stimulation in participants with vascular depression.
Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression. Increased metabolism in the anterior cingulate cortex (ACC) is a known predictor for antidepressant response. The authors assessed whether increased theta power within the ACC predicts rTMS response in participants with vascular depression. Sixty-five participants were randomized to active or sham rTMS. Outcome was assessed using the Hamilton Depression Rating Scale. Electroencephalography was obtained, and comparisons were made among each group with a normative database using low-resolution electromagnetic tomography. Results suggest that vascular depression participants respond well to rTMS and that increased low-theta power in the subgenual ACC predicts response to rTMS.
Narushima
Kenji
K
Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
McCormick
Laurie M
LM
Yamada
Thoru
T
Thatcher
Robert W
RW
Robinson
Robert G
RG
D000368:Aged; D000369:Aged, 80 and over; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D004569:Electroencephalography; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D020521:Stroke / Q000523:psychology*; D013826:Theta Rhythm; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D016896:Treatment Outcome