title: The origin of pre-eclampsia: from decidual "hyperoxia" to late hypoxia.
abstract: Normal gestation implants on a relatively hypoxic deciduas so that trophoblast deeply invades endometrium and angiogenesis seeks for oxygen supply. If implantation occurs before those hypoxic conditions occur, trophoblast invasion is defective, due to the relatively high oxygen tension in the decidual environment, laying the foundations for subsequent pre-eclampsia.
authors.affiliation: Department of Clinical Sciences, Section of Women's Health Sciences, Università Politecnica Marche, Ancona, Italy. a.l.tranquilli@univpm.it
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Tranquilli
authors.forename: Beatrice
authors.initials: B
authors.lastname: Landi
mesh_terms: D002248:Carbon Monoxide / Q000633:toxicity; D005260:Female; D006801:Humans; D018496:Hyperoxia / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D020738:Leptin / Q000502:physiology; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000209:etiology* / Q000503:physiopathology; D011247:Pregnancy; D012907:Smoking
chemical_list: D020738:Leptin; D002248:Carbon Monoxide