title: Unusual multiple gastric carcinoids with hypergastrinemia: report of a case.
abstract: We report the case of a patient demonstrating multiple gastric carcinoids with hypergastrinemia. A 50-year-old Japanese woman was admitted to our hospital for the further examination of multiple carcinoids of the stomach with hypergastrinemia, although she was asymptomatic. However, based on our clinical examination, this case seemed to be neither type I nor II carcinoid. We performed a total gastrectomy with D1 lymph node dissection. A pathological examination showed numerous endocrine micronests, hyperplasia of the parietal cells extending to the foveolar neck region, and numerous dilated oxyntic glands filled with eosinophilic secretions. Many parietal cells exhibited vacuolated cytoplasms and apical snouts. Furthermore, the dilated glands at the base of the mucosa had hyperchromatic nuclei and ciliated surfaces. The postoperative serum gastrin level was soon normalized to 47 pg/ml. This is only the third reported case of multiple gastric carcinoids with hypergastrinemia due to an intrinsic abnormality in the acid secretion of the parietal cells.
authors.affiliation: Department of Surgery, Hamanomachi Hospital, Fukuoka, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Nakata
authors.forename: Shinichi
authors.initials: S
authors.lastname: Aishima
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ichimiya
authors.forename: Takashi
authors.initials: T
authors.lastname: Yao
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsuura
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Seo
authors.forename: Eishi
authors.initials: E
authors.lastname: Nagai
authors.forename: Masayuki
authors.initials: M
authors.lastname: Okido
authors.forename: Masato
authors.initials: M
authors.lastname: Kato
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Nakagaki
authors.forename: Masazumi
authors.initials: M
authors.lastname: Tsuneyoshi
authors.forename: Masao
authors.initials: M
authors.lastname: Tanaka
mesh_terms: D002276:Carcinoid Tumor / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D005743:Gastrectomy; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D008197:Lymph Node Excision; D008875:Middle Aged; D010295:Parietal Cells, Gastric / Q000473:pathology; D013274:Stomach Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology
chemical_list: D005755:Gastrins