title: Anti-nociceptive and anti-inflammatory activities of ethanol extract of syzygium aromaticum flower bud in Wistar rats and mice.
abstract: The ethanol extracts of Syzygium aromaticum flower bud were tested for anti-nociceptive and anti-inflammatory effects in mice and Wistar rats which were carried out using acetic acid-induced abdominal contractions in mice and formalin-induced hind paw edema in Wistar rats. Three doses of the ethanol extract (50, 100, and 200 mg/kg body weight i.p.) were used for both studies. The extract had an LD(50) of 565.7 mg/kg body weight intraperitoneally in mice. The extracts produced significant effect (P<0.05) at all the three doses. Similarly, the anti-nociceptive activity produced significant effects (P<0.05) at all the three doses of the extract. The result supports the local use of the plant in painful and inflammatory conditions.
authors.affiliation: Department of Human Physiology, ABU, Zaria. yusuftanko @ yahoo.com
authors.forename: Y
authors.initials: Y
authors.lastname: Tanko
authors.forename: A
authors.initials: A
authors.lastname: Mohammed
authors.forename: M A
authors.initials: MA
authors.lastname: Okasha
authors.forename: A H
authors.initials: AH
authors.lastname: Umar
authors.forename: R A
authors.initials: RA
authors.lastname: Magaji