Determination of antihypertensive drug moexipril hydrochloride based on the enhancement effect of sodium dodecyl sulfate at carbon paste electrode.
Herein, an electrochemical differential pulse voltammetric method was developed for the determination of moexipril hydrochloride based on the enhancement effect of sodium dodecyl sulfate. The oxidation process has been carried out in Britton-Robinson buffer. Moexipril hydrochloride exhibits a well-defined irreversible oxidation peak over the entire pH range (2-11). The peak current varied linearly over the range from 4.0 x 10(-7) to 5.2 x 10(-6) mol L(-1). The limits of detection and quantification were 6.87 x 10(-8) mol L(-1) and 2.29 x 10(-7) mol L(-1), respectively. The recovery was found in the range from 99.65% to 100.76%. The relative standard deviation was found in the range from 0.429% to 0.845%. The proposed method possesses high sensitivity, accuracy and rapid response. Finally, this method was successfully used to determine moexipril hydrochloride in tablets.
Attia
Ali K
AK
National Organization for Drug Control and Research, P.O. Box 29, Cairo, Egypt. alikamal1978@hotmail.com
D000959:Antihypertensive Agents / Q000032:analysis* / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004563:Electrochemistry; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009824:Ointments; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry; D044005:Tetrahydroisoquinolines / Q000032:analysis* / Q000737:chemistry*
D000959:Antihypertensive Agents; D009824:Ointments; D013501:Surface-Active Agents; D044005:Tetrahydroisoquinolines; D012967:Sodium Dodecyl Sulfate; D002244:Carbon; C058302:moexipril