title: Characteristics of prolactin-releasing response to salsolinol in vivo in cattle.
abstract: The aims of the present study were to clarify the effect of salsolinol (SAL), a dopamine (DA)-derived endogenous compound, on the secretion of prolactin (PRL) in cattle. The experiments were performed from April to June using calves and cows. A single intravenous (i.v.) injection of SAL (5mg/kg body weight [BW]) or sulpiride (a DA receptor antagonist, 0.1mg/kg BW) significantly stimulated the release of PRL in male and female calves (P<0.05), though the response to SAL was smaller than that to sulpiride. The secretory pattern of PRL in response to SAL or sulpiride in female calves resembled that in male calves. A single i.v. injection of SAL or sulpiride significantly stimulated the release of PRL in cows (P<0.05). There was no significant difference in the PRL-releasing response between the SAL- and sulpiride-injected groups in cows. A single intracerebroventricular injection of SAL (10mg/head) also significantly stimulated the release of PRL in castrated calves (P<0.05). These results show that SAL is involved in the regulatory process for the secretion of PRL, not only in male and female calves, but also in cows. The results also suggest that the potency of the PRL-releasing response to SAL differs with the physiological status of cattle.
authors.affiliation: Faculty of Agriculture, Iwate University, Morioka, Japan. hashi@iwate-u.ac.jp <hashi@iwate-u.ac.jp>
authors.forename: T
authors.initials: T
authors.lastname: Hashizume
authors.forename: T
authors.initials: T
authors.lastname: Sawada
authors.forename: T
authors.initials: T
authors.lastname: Yaegashi
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: A Ezzat
authors.initials: AE
authors.lastname: Ahmed
authors.forename: Y
authors.initials: Y
authors.lastname: Goto
authors.forename: Y
authors.initials: Y
authors.lastname: Nakajima
authors.forename: J
authors.initials: J
authors.lastname: Jin
authors.forename: E
authors.initials: E
authors.lastname: Kasuya
authors.forename: G M
authors.initials: GM
authors.lastname: Nagy
mesh_terms: D000818:Animals; D002369:Castration; D002417:Cattle / Q000502:physiology*; D005260:Female; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D007546:Isoquinolines / Q000008:administration & dosage*; D007700:Kinetics; D008297:Male; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D013469:Sulpiride / Q000008:administration & dosage
chemical_list: D007546:Isoquinolines; D013469:Sulpiride; D011388:Prolactin; C036617:salsolinol