title: Prevalence and distribution of sensitization to foods in the European Community Respiratory Health Survey: a EuroPrevall analysis.
abstract: BACKGROUND
  Reports of adverse reactions to foods are increasing, but there is limited information on the comparative prevalence of sensitization to food allergens using standardized methods.
  
  
  METHODS
  Sera from the 'random sample' of young adults seen during the second phase of the European Community Respiratory Health Survey were analysed for IgE against 24 foods using ImmunoCAP. Sera were tested on five food mixes, and subsequently on individual foods in each positive mix.
  
  
  RESULTS
  Sera from 4522 individuals living in 13 countries were tested for at least one food allergen mix. Prevalence of sensitization to any of the 24 food allergens ranged from 24.6% in Portland (USA) to 7.7% in Reykjavik (Iceland). With few exceptions, the relative prevalence of sensitization to different foods was similar in all countries. Sensitization rates to egg, fish and milk were each less than 1%, and the most common sensitizations are not represented in current commercial mixes. The prevalence of sensitization to foods was not related to that of sensitization to aeroallergens but was related to the geometric mean total IgE for the country.
  
  
  CONCLUSIONS
  Sensitization to foods is common but highly variable. The relative prevalence of sensitization to different foods is more consistent than would be expected by chance, suggesting that quantity of consumption of specific foods does not determine prevalence. The aetiology of food sensitization is only partly similar to that for aeroallergens but is related to local levels of total IgE. This may provide an important clue to the origins of food sensitization.
authors.affiliation: Respiratory Epidemiology and Public Health, Imperial College, London, UK. p.burney@imperial.ac.uk
authors.forename: P
authors.initials: P
authors.lastname: Burney
authors.forename: C
authors.initials: C
authors.lastname: Summers
authors.forename: S
authors.initials: S
authors.lastname: Chinn
authors.forename: R
authors.initials: R
authors.lastname: Hooper
authors.forename: R
authors.initials: R
authors.lastname: van Ree
authors.forename: J
authors.initials: J
authors.lastname: Lidholm
mesh_terms: D000328:Adult; D000485:Allergens / Q000009:adverse effects / Q000276:immunology*; D001315:Australia / Q000453:epidemiology; D005060:Europe / Q000453:epidemiology; D005502:Food / Q000009:adverse effects*; D005512:Food Hypersensitivity / Q000453:epidemiology* / Q000209:etiology / Q000276:immunology; D006306:Health Surveys; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D015995:Prevalence; D014481:United States / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000485:Allergens; D007073:Immunoglobulin E