Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in Streptomyces coelicolor.
A tetR family transcriptional regulatory gene (SCO1712) was identified as a global antibiotic regulatory gene from a Streptomyces interspecies DNA microarray analysis. SCO1712 disruption in Streptomyces coelicolor not only upregulated antibiotic biosynthesis through pathway-specific regulators when a previously identified pleiotropic downregulatory wblA was expressed but also further stimulated antibiotic production in a wblA deletion mutant, implying that SCO1712 might encode a novel antibiotic downregulator.
Lee
Han-Na
HN
Department of Biological Engineering, Inha University, Incheon, South Korea.
Huang
Jianqiang
J
Im
Jong-Hyuk
JH
Kim
Seon-Hye
SH
Noh
Jun-Hee
JH
Cohen
Stanley N
SN
Kim
Eung-Soo
ES
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001426:Bacterial Proteins / Q000235:genetics*; D005809:Genes, Regulator; D009154:Mutation; D012097:Repressor Proteins / Q000235:genetics*; D013302:Streptomyces / Q000235:genetics; D048372:Streptomyces coelicolor / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D012097:Repressor Proteins