Radiation-associated liver injury.
The liver is a critically important organ that has numerous functions including the production of bile, metabolism of ingested nutrients, elimination of many waste products, glycogen storage, and plasma protein synthesis. The liver is often incidentally irradiated during radiation therapy (RT) for tumors in the upper- abdomen, right lower lung, distal esophagus, or during whole abdomen or whole body RT. This article describes the endpoints, time-course, and dose-volume effect of radiation on the liver.
Pan
Charlie C
CC
Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109-5010, USA. cpan@umich.edu
Kavanagh
Brian D
BD
Dawson
Laura A
LA
Li
X Allen
XA
Das
Shiva K
SK
Miften
Moyed
M
Ten Haken
Randall K
RK
D006801:Humans; D008099:Liver / Q000528:radiation effects*; D008113:Liver Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D008954:Models, Biological; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000150:complications* / Q000628:therapy; D011836:Radiation Tolerance; D012306:Risk