title: Macagigantin, a farnesylated flavonol from Macaranga gigantea.
abstract: A new farnesylated flavonol derivative, macagigantin (1), together with two known flavonoids, glyasperin A (2) and apigenin (3), had been isolated from the acetone extract of the leaves of Macaranga gigantea. The structure of the new compound was elucidated as 6-farnesylkaempferol based on its spectroscopic data, including UV, IR, 1D and 2D NMR, and HR-EI-MS spectra. Compounds 1-3 were evaluated for their cytotoxic properties against P-388 cells, their IC(50) values being 11.3, 6.0, and 5.1 microM, respectively.
authors.affiliation: Organic Chemistry Division, Institut Teknologi Bandung, Bandung, Indonesia.
authors.forename: Mulyadi
authors.initials: M
authors.lastname: Tanjung
authors.forename: Euis H
authors.initials: EH
authors.lastname: Hakim
authors.forename: Didin
authors.initials: D
authors.lastname: Mujahidin
authors.forename: Muhammad
authors.initials: M
authors.lastname: Hanafi
authors.forename: Yana M
authors.initials: YM
authors.lastname: Syah
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019665:Euphorbiaceae / Q000737:chemistry*; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007214:Indonesia; D007941:Leukemia P388; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D044948:Flavonols; C547995:macagigantin