title: Platinum(II) Enyne Cycloisomerization Catalysis: Intermediates and Resting States.
abstract: In situ generated [(PPP)Pt][BF(4)](2) (PPP = triphos) catalyzes the cycloisomerization of 1,6-enyne-ols by initiative pi-activation of the alkyne. This generates an isolable cationic Pt-alkenyl species which subsequently participates in turnover limiting protonolysis with in situ generated acid. This latter reactivity contrasts cationic Pt-alkyls which are more difficult to protonolyze. Mechanistic studies on isolated Pt-alkenyls, and deuterium labeling helped to elucidate the mechanistic details.
authors.affiliation: Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290.
authors.forename: D Luke
authors.initials: DL
authors.lastname: Nelsen
authors.forename: Michel R
authors.initials: MR
authors.lastname: Gagné