Stomach dysfunction in diabetes mellitus: emerging technology and pharmacology.
Gastroparesis and other types of gastric dysfunction result in substantial morbidity in diabetes patients. The pathophysiology of these disorders is incompletely understood. This article reviews techniques applicable to the assessment of gastric function in diabetes patients, including the measurement of emptying, accommodation, and contractility. Available treatment options are also reviewed, including novel yet unapproved serotonin 5-HT(4) agonist pharmacological treatments, as well as the role of endoscopic, surgical, and device treatments of gastroparesis.
Szarka
Lawrence A
LA
Clinical Enteric Neuroscience Translational and Epidemiological Research (CENTER), College of Medicine, Mayo Clinic, Rochester, Minnesota.
Camilleri
Michael
M
D050110:Bariatric Surgery / Q000379:methods; D048909:Diabetes Complications / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D003929:Diabetic Neuropathies / Q000175:diagnosis / Q000628:therapy; D003938:Diagnostic Techniques, Digestive System / Q000639:trends*; D004358:Drug Therapy / Q000639:trends; D004558:Electric Stimulation / Q000379:methods; D005769:Gastrointestinal Motility / Q000502:physiology; D018589:Gastroparesis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans; D010600:Pharmacology / Q000639:trends*; D013272:Stomach Diseases / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*