A convenient strategy for the annulation of aryl scaffold to A/B-ring steroids under microwave irradiation.
A facile strategy for the annulation of 2,6-dicyanoaniline moiety to steroidal A/B-ring is described from base catalyzed and microwave-promoted reaction of steroidal 3-keto-2-hydroxymethylenes with malononitrile in high yields. The generality of the reaction has been extended to non-steroidal cyclic and aliphatic ketohydroxylmethylenes.
Barthakur
Madan G
MG
Medicinal Chemistry Division, North-East Institute of Science and Technology (CSIR), Jorhat, Assam 785006, India.
Hasib
Abdul
A
Gogoi
Junali
J
Boruah
Romesh C
RC
D000814:Aniline Compounds / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D013256:Steroids / Q000138:chemical synthesis / Q000737:chemistry*
D000814:Aniline Compounds; D013256:Steroids