title: Relationship between serum concentrations of organochlorine pesticides and metabolic syndrome among non-diabetic adults.
abstract: OBJECTIVE
  This study was performed to investigate if organochlorine pesticides (OCPs) were associated with metabolic syndrome and insulin resistance among non-diabetes.
  
  
  METHODS
  Among subjects who participated in a community-based health survey, 50 non-diabetic subjects with metabolic syndrome and 50 normal controls were selected. Insulin resistance was measured by the homeostasis model assessment (HOMA-IR). Eight OCPs were selected.
  
  
  RESULTS
  After adjusting for confounders except for body mass index (BMI), beta-hexachlorocyclohexane (beta-HCH) and heptachlor epoxide were positively associated with metabolic syndrome. Odds ratios across tertiles of beta-HCH and heptachlor epoxide were 1.0, 3.2 and 4.4, and 1.0, 4.0 and 6.0, respectively (p for trend = 0.01 and <0.01). After additional adjustment for body mass index (BMI), heptachlor epoxide still showed an increasing trend with adjusted odds ratios of 1.0, 4.1, and 4.6 (p for trend = 0.10). When the five components of metabolic syndrome (with the definition of high fasting glucose (> or =100 mg/dL)) were separately analyzed, all components were positively, but not significantly, associated with heptachlor epoxide. As the serum concentration of heptachlor epoxide increased, HOMA-IR increased significantly in subjects with metabolic syndrome even after adjusting for BMI (p value <0.05 and <0.01).
  
  
  CONCLUSIONS
  Despite the small sample size, this study suggests that the background exposure to some OCPs may be associated with metabolic syndrome.
authors.affiliation: Department of Preventive Medicine, School of Medicine, Kyungpook National University, Korea.
authors.forename: Sun Kyun
authors.initials: SK
authors.lastname: Park
authors.forename: Hyo Kyung
authors.initials: HK
authors.lastname: Son
authors.forename: Sung Kook
authors.initials: SK
authors.lastname: Lee
authors.forename: Jung Ho
authors.initials: JH
authors.lastname: Kang
authors.forename: Yoon Seok
authors.initials: YS
authors.lastname: Chang
authors.forename: David R
authors.initials: DR
authors.lastname: Jacobs
authors.forename: Duk Hee
authors.initials: DH
authors.lastname: Lee
mesh_terms: D001786:Blood Glucose; D001794:Blood Pressure; D015992:Body Mass Index; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006306:Health Surveys; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced*; D008875:Middle Aged; D010575:Pesticides / Q000633:toxicity*
chemical_list: D001786:Blood Glucose; D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D008055:Lipids; D010575:Pesticides