Oral administration of Lactobacillus plantarum Lq80 and Megasphaera elsdenii iNP-001 induces efficient recovery from mucosal atrophy in the small and the large intestines of weaning piglets.
Weaning causes atrophy of intestinal mucosa and a drop of IgA protection in piglets which increases vulnerability to pathogenic infections. Probiotic lactobacilli may support recovery from such weaning stresses. Butyrate-produce bacteria may support the growth of colonic mucosa. Megasphaera elsdenii, a lactate-utilizing butyrate producer, may help butyrate production particularly when combined with lactobacilli. Weaned piglets (Experiment 1: 20 days old, Experiment 2: 28 days old) were orally dosed once a day with either (L) 10(10) (cell/dose) L. plantarum Lq80, or (LM) 10(10) (cell/dose) Lq80 with 10(9) (cell/dose) M. elsdenii iNP-001. Lq80 was contained in capsules resistant to gastric digestion. M. elsdenii was contained in capsules resistant to gastric and intestinal digestion. An untreated control (C) was also prepared. After 2 weeks of administration, L. plantarum enhanced the recovery from the villous atrophy in both experiments. The rectal and colonic IgA tended to be higher in L and LM than in C in Experiment 1. Colonic butyrate was higher in LM than in the others in Experiment 1. The thickness of the colonic mucosa was greater in LM than in the others in Experiment 1. In early weaned piglets, the effects of L. plantarum and M. elsdenii were clear.
Yoshida
Yoko
Y
Laboratory of Animal Science, Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Shimogamo, Kyoto, Japan.
Tsukahara
Takamitsu
T
Ushida
Kazunari
K
D000284:Administration, Oral; D000818:Animals; D001284:Atrophy; D002087:Butyrates / Q000378:metabolism; D007413:Intestinal Mucosa / Q000473:pathology*; D007420:Intestine, Large / Q000382:microbiology; D007421:Intestine, Small / Q000382:microbiology; D048191:Lactiplantibacillus plantarum; D045851:Megasphaera; D019936:Probiotics / Q000627:therapeutic use; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy*
D002087:Butyrates