title: [Rheopheresis for recurrent sudden hearing loss : therapeutic options for patients refractory to infusion therapy].
abstract: OBJECTIVE
  For patients suffering from recurrent sudden hearing loss (SHL) that is refractory to infusion therapy, new therapeutic options must be established.
  
  
  METHODS
  Patients suffering from recurrent and progressive SHL refractory to infusion therapy according to German guidelines were analysed retrospectively. After unsuccessful infusion therapy following the last onset of SHL, patients were treated with Rheopheresis twice. Hearing gain and recovery of speech discrimination were analysed.
  
  
  RESULTS
  Twenty-five patients with a mean of 2.1+/-0.4 events of SHL within 30.0+/-21.6 months were examined. The patients' mean hearing loss before the first onset of SHL was 34 dB and was reduced by infusion therapy to 20 dB. With the second onset of SHL, hearing loss remained almost unchanged after infusion therapy. Patients showed a mean improvement of 20 dB after two consecutive Rheopheresis treatments. Forty percent showed complete remission of SHL, and a further 28% showed partial remission.
  
  
  CONCLUSIONS
  Rheopheresis can efficiently improve the hearing of patients with recurrent SHL refractory to infusion therapy.
authors.affiliation: HNO-Klinik, Klinikum Lüdenscheid, Lüdenscheid, Deutschland.
authors.forename: S
authors.initials: S
authors.lastname: Uygun-Kiehne
authors.forename: R
authors.initials: R
authors.lastname: Straube
authors.forename: A
authors.initials: A
authors.lastname: Heibges
authors.forename: R
authors.initials: R
authors.lastname: Klingel
authors.forename: H
authors.initials: H
authors.lastname: Davids
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D003639:Hearing Loss, Sudden / Q000628:therapy*; D018718:Home Infusion Therapy; D006801:Humans; D007223:Infant; D008297:Male; D010956:Plasmapheresis / Q000379:methods*; D055502:Secondary Prevention; D017211:Treatment Failure; D016896:Treatment Outcome