title: Invasive adenocarcinoma of the prostate with urethral tumor.
abstract: Metastases of prostate cancer to the penis and urethra are rare and often represent advanced disease. We describe a case of newly diagnosed prostatic adenocarcinoma with metastases to the corpus spongiosum, cavernosum, and the anterior urethra. A male patient, 77 years of age, initially had lower urinary tract obstruction symptoms. His prostate-specific antigen level was 5.02 ng/mL. Digital rectal examination disclosed stony hard tumors at both lobes of the prostate. Transrectal ultrasound-guided biopsy of the prostate revealed adenocarcinoma over both lobes; the Gleason score was 4 + 4 = 8. Cystoscopy showed a penile urethral tumor and biopsy disclosed metastatic adenocarcinoma of the prostate; the Gleason score was 4 + 4 = 8. The patient initially received hormone therapy. Biochemical failure developed after 15 months and rapidly progressed to a hormone-refractory stage. Docetaxel was then prescribed. The patient died in the 25(th) month after the diagnosis.
authors.affiliation: Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
authors.forename: Chi-Feng
authors.initials: CF
authors.lastname: Hung
authors.forename: Chen-Hui
authors.initials: CH
authors.lastname: Lee
authors.forename: Siu-Wan
authors.initials: SW
authors.lastname: Hung
authors.forename: Kun-Yuan
authors.initials: KY
authors.lastname: Chiu
authors.forename: Chen-Li
authors.initials: CL
authors.lastname: Cheng
authors.forename: Chi-Rei
authors.initials: CR
authors.lastname: Yang
authors.forename: Chun-Jung
authors.initials: CJ
authors.lastname: Chen
authors.forename: Jian-Ri
authors.initials: JR
authors.lastname: Li
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000368:Aged; D006801:Humans; D008297:Male; D011379:Prognosis; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000473:pathology*; D014523:Urethral Neoplasms / Q000556:secondary*
chemical_list: D017430:Prostate-Specific Antigen