title: Lip cancer: incidence, trends, histology and survival: 1970-2006.
abstract: BACKGROUND
  High levels of lip cancer have been reported among Israelis over the last four decades. Epidemiological descriptions and analyses for this region have not previously been presented.
  
  
  OBJECTIVE
  To establish the incidence, trends and histology of lip cancer and associated demographic variables in Israel over time.
  
  
  METHODS
  Data for 1970-2006 were derived from the Israel National Cancer Registry. Incidence and trends over time and analyses by lip site, sex, age, origin, histology and 5-year survival were studied.
  
  
  RESULTS
  Of 4337 new cases, most were found among men (61.4%), people aged over 53 years (75.5%), and those with lighter skin (62.6%). Lip cancer cases were 40 times more prevalent in the external than in the inner lip. The dominant tumour type was squamous cell carcinoma at the external lower lip and intraoral lip mucosa (predominantly in men) and basal cell carcinoma (originating from skin) at the external upper lip (predominantly in women). Minor salivary gland tumours, melanoma and metastases were also reported. Slight increases in the trend of upper lip cancer and decreases for lower lip cancer were reported.
  
  
  CONCLUSIONS
  Men, fair-skinned individuals and those over 53 years of age were at higher risk for lip cancer. A higher incidence of external lip cancer, compared with internal, may indicate a major role for sun exposure rather than smoking. The effect of public awareness campaigns as well as occupational changes, both related to sun exposure, should be studied carefully as potential factors in the changing incidence of lip tumours.
authors.affiliation: Department of Oral Medicine, Hebrew University Hadassah School of Dental Medicine, PO Box 12272, Jerusalem 91120, Israel. rakefetc@hadassah.org.il
authors.forename: R
authors.initials: R
authors.lastname: Czerninski
authors.forename: A
authors.initials: A
authors.lastname: Zini
authors.forename: H D
authors.initials: HD
authors.lastname: Sgan-Cohen
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002280:Basal Cell Carcinoma / Q000453:epidemiology / Q000401:mortality / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000401:mortality / Q000473:pathology; D005260:Female; D005544:Forecasting; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D008048:Lip Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D017678:Sex Distribution; D016019:Survival Analysis; D055815:Young Adult