Impaired awareness of deficits and neuropsychiatric symptoms in early Alzheimer's disease: the Danish Alzheimer Intervention Study (DAISY).
Impaired awareness may be associated with increased neuropsychiatric symptoms in moderate to severe Alzheimer's disease, but relatively little is known about the association in early Alzheimer's disease. The aim of this study was to investigate if impaired awareness was associated with a higher frequency of neuropsychiatric symptoms in early Alzheimer's disease. In a Danish multicenter study, 321 patients with MMSE score > or =20 were evaluated. Patients with poor insight had significantly more neuropsychiatric symptoms than patients with full insight. When patients had increasing neuropsychiatric symptoms, caregivers reported higher levels of distress.
Vogel
Asmus
A
Memory Disorders Research Group, Department of Neurology, Neuroscience Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. asmus.vogel@rh.regionh.dk
Waldorff
Frans Boch
FB
Waldemar
Gunhild
G
D000368:Aged; D000369:Aged, 80 and over; D000377:Agnosia / Q000175:diagnosis* / Q000209:etiology*; D000544:Alzheimer Disease / Q000175:diagnosis / Q000523:psychology*; D001364:Awareness; D001921:Brain / Q000503:physiopathology*; D003718:Denmark; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D012042:Registries; D012720:Severity of Illness Index; D016037:Single-Blind Method; D011795:Surveys and Questionnaires