title: Incidence of residual neuromuscular blockade in a post-anaesthetic care unit.
abstract: We conducted a prospective observational study to assess the incidence of residual neuromuscular blockade (RNMB) in a post-anaesthetic care unit (PACU) of a tertiary hospital. The subjects were 102 patients undergoing general anaesthesia with neuromuscular blockade (NMB). The procedural anaesthetists were unaware of their patients' inclusion in the study, and the choice of muscle relaxant and use of reversal agents were at the anaesthetists' discretion. On arrival to the PACU, the train-of-four ratio was assessed using electromyography, repeated every five minutes until the train-of-four ratio exceeded 0.9. RNMB was defined as a train-of-four ratio < 0.9. The requirement for airway support, incidence of desaturation while in the PACU and time to eligibility for PACU discharge were recorded. The mean interval between the last dose of relaxant and arrival in the PACU for patients with RNMB was 81 minutes. An intermediate-acting muscle relaxant had been used for most patients. Despite this, RNMB was observed in 31% (95% confidence interval 25 to 47%) of patients. Our findings suggest that RNMB in the PACU is common. As RNMB may predispose to postoperative complications, anaesthetists should utilise quantitative monitoring to assess neuromuscular blockade and optimise reversal use. Anaesthetists should be aware that intervals between the last dose of relaxant of well over one hour do not exclude the possibility of RNMB, even when using intermediate-acting neuromuscular blockade agents.
authors.affiliation: Department of Anaesthesia, Auckland City Hospital, New Zealand.
authors.forename: P C
authors.initials: PC
authors.lastname: Yip
authors.forename: J A
authors.initials: JA
authors.lastname: Hannam
authors.forename: A J D
authors.initials: AJ
authors.lastname: Cameron
authors.forename: D
authors.initials: D
authors.lastname: Campbell
mesh_terms: D000761:Anesthesia Department, Hospital; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009125:Muscle Relaxants, Central / Q000009:adverse effects*; D019148:Neuromuscular Blockade / Q000009:adverse effects*; D009520:New Zealand / Q000453:epidemiology; D011182:Postoperative Care; D011183:Postoperative Complications / Q000453:epidemiology* / Q000503:physiopathology; D011997:Recovery Room; D012121:Respiration, Artificial; D016896:Treatment Outcome
chemical_list: D009125:Muscle Relaxants, Central