title: Molecular mechanisms involved in the adaptation to amino acid limitation in mammals.
abstract: In mammals, metabolic adaptations are required to cope with episodes of protein deprivation and malnutrition. Consequently, mammals have to adjust physiological functions involved in the adaptation to amino acid availability. Part of this regulation involves the modulation of the expression of numerous genes. In particular, it has been shown that amino acids by themselves can modify the expression of target genes. This review describes the regulation of amino acids homeostasis and the their role as signal molecules. The recent advances in the understanding of the molecular mechanisms involved in the control of mammalian gene expression in response to amino acid limitation will be described.
authors.affiliation: Unité de Nutrition Humaine, UMR 1019, INRA de Theix, 63122 Saint Genès Champanelle, France.
authors.forename: Cédric
authors.initials: C
authors.lastname: Chaveroux
authors.forename: Sarah
authors.initials: S
authors.lastname: Lambert-Langlais
authors.forename: Yoan
authors.initials: Y
authors.lastname: Cherasse
authors.forename: Julien
authors.initials: J
authors.lastname: Averous
authors.forename: Laurent
authors.initials: L
authors.lastname: Parry
authors.forename: Valérie
authors.initials: V
authors.lastname: Carraro
authors.forename: Céline
authors.initials: C
authors.lastname: Jousse
authors.forename: Anne-Catherine
authors.initials: AC
authors.lastname: Maurin
authors.forename: Alain
authors.initials: A
authors.lastname: Bruhat
authors.forename: Pierre
authors.initials: P
authors.lastname: Fafournoux
mesh_terms: D051701:Activating Transcription Factor 4 / Q000378:metabolism; D000222:Adaptation, Physiological / Q000235:genetics; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001483:Base Sequence; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism
chemical_list: D000596:Amino Acids; D051701:Activating Transcription Factor 4; D017346:Protein Serine-Threonine Kinases