title: The role of Fcgamma receptors in murine autoimmune thrombocytopenia.
abstract: Immune thrombocytopenia (ITP) can become a life-threatening condition that requires immediate medical attention. The loss in platelet numbers during ITP can be induced by a variety of triggers. Anti-platelet antibodies of several isotypes and subclasses are a major cause for ITP and are a hallmark of many complex autoimmune diseases such as systemic lupus erythematosus. Mouse models have been important to understand the effector pathways involved in antibody-mediated platelet depletion. Therapeutic interventions based on these results have been proven successful in treating human ITP, thus validating the use of these model systems. One major problem that remains to be answered is which cell populations are crucial for platelet removal. Targeting these cells directly might be a novel therapeutic strategy and will also be important to understand the underlying biological mechanisms.
authors.affiliation: Laboratory for Experimental Immunology and Immunotherapy, Nikolaus-Fiebiger-Centre for Molecular Medicine, Medical Department III, University of Erlangen-Nuremberg, Glückstr. 6, 91054, Erlangen, Germany.
authors.forename: Markus
authors.initials: M
authors.lastname: Biburger
authors.forename: Susanne
authors.initials: S
authors.lastname: Aschermann
authors.forename: Anja
authors.initials: A
authors.lastname: Lux
authors.forename: Falk
authors.initials: F
authors.lastname: Nimmerjahn
mesh_terms: D000818:Animals; D015551:Autoimmunity; D001792:Blood Platelets / Q000276:immunology* / Q000473:pathology; D004195:Disease Models, Animal; D007141:Immunoglobulin Fc Fragments / Q000276:immunology*; D051379:Mice; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000276:immunology*; D017452:Receptors, IgG / Q000276:immunology*; D013921:Thrombocytopenia / Q000276:immunology
chemical_list: D007141:Immunoglobulin Fc Fragments; D017452:Receptors, IgG