title: Status of bi- and multi-nuclear platinum anticancer drug development.
abstract: Cisplatin has become one of the most commonly used compounds for the treatment of a wide spectrum of human malignancies. Unfortunately, cisplatin has several major drawbacks. Driven by the impressive impact of cisplatin on cancer chemotherapy, great efforts have been made to develop new derivatives with improved pharmacological properties. Among the over 30 platinum agents which have entered clinical trials after the onset of clinical studies with cisplatin in the early 1970s, only carboplatin and oxaliplatin have received worldwide approval so far, nedaplatin, lobaplatin and heptaplatin have gained regionally limited approval. It has become quite evident that mere analogues of cisplatin or carboplatin will not probably offer any substantial clinical advantages over the existing drugs. Therefore, people turned to synthesize non-classical platinum anticancer drugs which were capable of forming a different range of DNA adducts which could display a different spectrum of anticancer activity compared to cisplatin. This review will summarize the structural types and structure-activity rules of non-classical bi- and multi-nuclear platinum anticancer drugs, and discuss their future potential as anticancer agents.
authors.affiliation: College of Chemistry & Environmental Science, Chemical Biology Laboratory, Hebei University, Baoding 071002, China. jczhang6970@yahoo.com.cn
authors.forename: Jinchao
authors.initials: J
authors.lastname: Zhang
authors.forename: Liwei
authors.initials: L
authors.lastname: Wang
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Xing
authors.forename: Dandan
authors.initials: D
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.forename: Xiaoliu
authors.initials: X
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use*; D001952:Bridged-Ring Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D018736:DNA Adducts / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009944:Organoplatinum Compounds / Q000737:chemistry / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001952:Bridged-Ring Compounds; D018736:DNA Adducts; D009944:Organoplatinum Compounds