Hunger and negative alliesthesia to aspartame and sucrose in patients treated with antipsychotic drugs and controls.
The present study explores sweet stimuli effects on hunger and negative alliesthesia in patients treated with antipsychotic drugs and controls. Those phenomena were examined in relation to previous weight gain, eating and weight-related cognitions and type of sweet stimuli: aspartame or sucrose. Alliesthesia is delayed in participants who gained weight regardless of cross group differences. A similar reduction of hunger was observed after the intake of two kinds of sweet stimuli (aspartame or sucrose) whereas alliesthesia measures were not affected. Whereas atypical antipsychotic drug-induced weight gain is linked to delayed satiety, the phenomenon is similar in magnitude in non-psychiatric controls who gained weight.
Khazaal
Y
Y
Division of Substance Abuse, University Hospitals of Geneva, Rue Verte 2, CH-1205 Geneva, Switzerland. yasser.khazaal@hcuge.ch
Chatton
A
A
Claeys
F
F
Ribordy
F
F
Khan
R
R
Zullino
D
D
D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D001218:Aspartame / Q000008:administration & dosage / Q000494:pharmacology; D001569:Benzodiazepines / Q000008:administration & dosage / Q000494:pharmacology; D002253:Carbonated Beverages; D003024:Clozapine / Q000008:administration & dosage / Q000494:pharmacology; D003987:Dibenzothiazepines / Q000008:administration & dosage / Q000494:pharmacology; D004311:Double-Blind Method; D005518:Food Preferences / Q000187:drug effects; D006801:Humans; D006815:Hunger / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D057181:Pleasure / Q000187:drug effects; D011618:Psychotic Disorders / Q000188:drug therapy; D000069348:Quetiapine Fumarate; D018967:Risperidone / Q000008:administration & dosage / Q000494:pharmacology; D012559:Schizophrenia / Q000188:drug therapy; D013395:Sucrose / Q000008:administration & dosage / Q000494:pharmacology; D011795:Surveys and Questionnaires; D013549:Sweetening Agents / Q000008:administration & dosage / Q000494:pharmacology; D013649:Taste / Q000187:drug effects*; D013997:Time Factors; D055815:Young Adult
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D013549:Sweetening Agents; D001569:Benzodiazepines; D000069348:Quetiapine Fumarate; D013395:Sucrose; D003024:Clozapine; D018967:Risperidone; D000077152:Olanzapine; D001218:Aspartame