[Comparative pharmacokinetics of dihydroquercetin in rats upon peroral administration of a parent compound and liposomal flamen D].
The pharmacokinetics of dihydroquercetin (DHQ) in the forms of parent substance and a new liposomal formulation (Flamena D) have been studied in rats upon single peroral administration in a dose of 50 mg/kg. DHQ concentration after enzymatic hydrolysis in the blood plasma was determined by HPLC with UV detection. The elimination half-life of DHQ introduced in the form of Flamena D was about T(1/2) = 1.3 h. The relative bioavailability of DHQ after the administration of Flamena D amounted to 159% in comparison to that of the parent substance of DHQ.
Zherdev
V P
VP
Kolyvanov
G B
GB
Litvin
A A
AA
Sariev
A K
AK
Viglinskaia
A O
AO
Gekkiev
B I
BI
Grigor'ev
A M
AM
Gorlov
V V
VV
D000818:Animals; D008081:Liposomes; D008297:Male; D011794:Quercetin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D051381:Rats
D008081:Liposomes; D011794:Quercetin; C003377:taxifolin