Case of livedoid vasculopathy with extensive dermal capillary thrombi.
Livedoid vasculopathy (LV) is thought to be a thrombogenic disorder. Here, we report a case of LV presenting livedo reticularis with leg ulcers clinically and many thrombogenic cutaneous vessels histologically. These features strongly suggested the presence of thrombogenic factors involved with the development of the lesions. After examination of various possible thrombogenic factors including phosphatidylserine-dependent anti-prothrombin antibody, we failed to detect any responsible thrombogenic factors for this case of LV. Recently, diverse thrombogenic factors have been reported to be involved in LV. This case may suggest that unknown thrombogenic factors are additionally related to LV pathogenesis.
Shimizu
Akira
A
Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma 371-8511, Japan. ashimizu@med.gunma-u.ac.jp
Tamura
Atsushi
A
Yamanaka
Masayoshi
M
Amano
Hiroo
H
Nagai
Yayoi
Y
Ishikawa
Osamu
O
D000293:Adolescent; D002196:Capillaries / Q000473:pathology; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D054068:Livedo Reticularis / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D010718:Phosphatidylserines / Q000032:analysis; D011516:Prothrombin / Q000032:analysis; D012867:Skin / Q000098:blood supply*; D013917:Thrombin / Q000032:analysis; D013927:Thrombosis / Q000150:complications / Q000175:diagnosis*
D010718:Phosphatidylserines; D011516:Prothrombin; D013917:Thrombin; C478632:Thrombogen