title: GMOtrack: generator of cost-effective GMO testing strategies.
abstract: Commercialization of numerous genetically modified organisms (GMOs) has already been approved worldwide, and several additional GMOs are in the approval process. Many countries have adopted legislation to deal with GMO-related issues such as food safety, environmental concerns, and consumers' right of choice, making GMO traceability a necessity. The growing extent of GMO testing makes it important to study optimal GMO detection and identification strategies. This paper formally defines the problem of routine laboratory-level GMO tracking as a cost optimization problem, thus proposing a shift from "the same strategy for all samples" to "sample-centered GMO testing strategies." An algorithm (GMOtrack) for finding optimal two-phase (screening-identification) testing strategies is proposed. The advantages of cost optimization with increasing GMO presence on the market are demonstrated, showing that optimization approaches to analytic GMO traceability can result in major cost reductions. The optimal testing strategies are laboratory-dependent, as the costs depend on prior probabilities of local GMO presence, which are exemplified on food and feed samples. The proposed GMOtrack approach, publicly available under the terms of the General Public License, can be extended to other domains where complex testing is involved, such as safety and quality assurance in the food supply chain.
authors.affiliation: Jozef Stefan Institute, Department of Knowledge Technologies, Jamova 39, 1000 Ljubljana, Slovenia. petra.kralj.novak@ijs.si
authors.forename: Petra Krau
authors.initials: PK
authors.lastname: Novak
authors.forename: Kristina
authors.initials: K
authors.lastname: Gruden
authors.forename: Dany
authors.initials: D
authors.lastname: Morisset
authors.forename: Nada
authors.initials: N
authors.lastname: Lavrac
authors.forename: Dejan
authors.initials: D
authors.lastname: Stebih
authors.forename: Ana
authors.initials: A
authors.lastname: Rotter
authors.forename: Jana
authors.initials: J
authors.lastname: Zel
mesh_terms: D000465:Algorithms; D003362:Cost-Benefit Analysis; D003365:Costs and Cost Analysis; D016208:Databases, Factual; D005504:Food Analysis / Q000191:economics* / Q000592:standards; D030841:Food, Genetically Modified / Q000009:adverse effects / Q000191:economics* / Q000592:standards; D030781:Organisms, Genetically Modified; D015203:Reproducibility of Results