title: Synthesis, characterization and antihypertensive activity of pyridazinone derivatives.
abstract: Some 6-(substituted-phenyl)-2-(substitutedmethyl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by reacting 6-substituted-phenyl-4,5-dihydropyridazin-3(2H)-one with cyclic secondary amine under Mannich reaction conditions. The final compounds (15-70) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 16, 19, 24, 30, 39, 42 and 45 showed good antihypertensive activity.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi-110062, India. anees_56@yahoo.co.in
authors.forename: Anees A
authors.initials: AA
authors.lastname: Siddiqui
authors.forename: Ravinesh
authors.initials: R
authors.lastname: Mishra
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shaharyar
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D011724:Pyridazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
chemical_list: D000959:Antihypertensive Agents; D011724:Pyridazines; C062482:pyridazine