A new facile synthesis of 3-amidoindole derivatives and their evaluation as potential GSK-3beta inhibitors.
3-Amidoindoles were synthesized from commercially available arylhydrazines and propargylamines over Zn-salt mediated one pot procedure in excellent regioselectivity and up to 94% yield.
Pews-Davtyan
Anahit
A
Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, D-18059, Rostock, Germany.
Tillack
Annegret
A
Schmöle
Anne-Caroline
AC
Ortinau
Stefanie
S
Frech
Moritz J
MJ
Rolfs
Arndt
A
Beller
Matthias
M
D002460:Cell Line; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology*; D015394:Molecular Structure; D051176:beta Catenin / Q000378:metabolism
D007211:Indoles; D051176:beta Catenin; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3