title: A detailed investigation of the aza-Prins reaction.
abstract: The development of a Lewis acid-promoted aza-Prins reaction to form piperidines and pyrrolidines is described. Indium trichloride has been found to be a highly successful and mild Lewis acid for promoting this reaction. A thorough mechanistic investigation is described, including the factors that influence the formation of the 5- or 6-membered ring product(s).
authors.affiliation: School of Biological and Chemical Sciences, Joseph Priestley Building, Queen Mary University of London, Mile End Road, London, United Kingdom E1 4NS. A.Dobbs@qmul.ac.uk
authors.forename: Adrian P
authors.initials: AP
authors.lastname: Dobbs
authors.forename: Sebastien J J
authors.initials: SJ
authors.lastname: Guesné
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Parker
authors.forename: John
authors.initials: J
authors.lastname: Skidmore
authors.forename: Richard A
authors.initials: RA
authors.lastname: Stephenson
authors.forename: Mike B
authors.initials: MB
authors.lastname: Hursthouse
mesh_terms: D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D010880:Piperidines; D011759:Pyrrolidines