title: Variants in FAM13A are associated with chronic obstructive pulmonary disease.
abstract: We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function. We identified a new susceptibility locus at 4q22.1 in FAM13A and replicated this association in one case-control group (n = 1,006) and two family-based cohorts (n = 3,808) (rs7671167, combined P = 1.2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83).
authors.affiliation: Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Michael H
authors.initials: MH
authors.lastname: Cho
authors.forename: Nadia
authors.initials: N
authors.lastname: Boutaoui
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Klanderman
authors.forename: Jody S
authors.initials: JS
authors.lastname: Sylvia
authors.forename: John P
authors.initials: JP
authors.lastname: Ziniti
authors.forename: Craig P
authors.initials: CP
authors.lastname: Hersh
authors.forename: Dawn L
authors.initials: DL
authors.lastname: DeMeo
authors.forename: Gary M
authors.initials: GM
authors.lastname: Hunninghake
authors.forename: Augusto A
authors.initials: AA
authors.lastname: Litonjua
authors.forename: David
authors.initials: D
authors.lastname: Sparrow
authors.forename: Christoph
authors.initials: C
authors.lastname: Lange
authors.forename: Sungho
authors.initials: S
authors.lastname: Won
authors.forename: James R
authors.initials: JR
authors.lastname: Murphy
authors.forename: Terri H
authors.initials: TH
authors.lastname: Beaty
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Regan
authors.forename: Barry J
authors.initials: BJ
authors.lastname: Make
authors.forename: John E
authors.initials: JE
authors.lastname: Hokanson
authors.forename: James D
authors.initials: JD
authors.lastname: Crapo
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Kong
authors.forename: Wayne H
authors.initials: WH
authors.lastname: Anderson
authors.forename: Ruth
authors.initials: R
authors.lastname: Tal-Singer
authors.forename: David A
authors.initials: DA
authors.lastname: Lomas
authors.forename: Per
authors.initials: P
authors.lastname: Bakke
authors.forename: Amund
authors.initials: A
authors.lastname: Gulsvik
authors.forename: Sreekumar G
authors.initials: SG
authors.lastname: Pillai
authors.forename: Edwin K
authors.initials: EK
authors.lastname: Silverman
mesh_terms: D016022:Case-Control Studies; D002894:Chromosomes, Human, Pair 4; D005190:Family; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D015810:Linkage Disequilibrium; D015337:Multicenter Studies as Topic; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000209:etiology / Q000235:genetics*; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000502:physiology; D012907:Smoking / Q000009:adverse effects / Q000235:genetics
chemical_list: D043562:Receptors, G-Protein-Coupled