title: Mammalian recombination hot spots: properties, control and evolution.
abstract: Recombination, together with mutation, generates the raw material of evolution, is essential for reproduction and lies at the heart of all genetic analysis. Recent advances in our ability to construct genome-scale, high-resolution recombination maps and new molecular techniques for analysing recombination products have substantially furthered our understanding of this important biological phenomenon in humans and mice: from describing the properties of recombination hot spots in male and female meiosis to the recombination landscape along chromosomes. This progress has been accompanied by the identification of trans-acting systems that regulate the location and relative activity of individual hot spots.
authors.affiliation: The Jackson Laboratory, Bar Harbor, Maine 04609, USA. ken.paigen@jax.org
authors.forename: Kenneth
authors.initials: K
authors.lastname: Paigen
authors.forename: Petko
authors.initials: P
authors.lastname: Petkov
mesh_terms: D000818:Animals; D003434:Crossing Over, Genetic; D019143:Evolution, Molecular; D005260:Female; D005785:Gene Conversion; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008540:Meiosis / Q000235:genetics; D051379:Mice; D008957:Models, Genetic; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D011995:Recombination, Genetic; D012641:Selection, Genetic; D012727:Sex Characteristics; D013094:Spermatozoa / Q000378:metabolism