Cortical dopamine D2/D3 receptors and verbal memory in man.
BACKGROUND
It has been previously reported that hippocampal dopamine D2/D3 receptors are involved in the regulation of verbal memory and learning in healthy volunteers. We tested this hypothesis further and studied whether cortical dopamine D2/D3 receptor availability in vivo is associated with verbal memory as assessed with the revised Wechsler Memory Scale (WMS-R).


METHODS
Forty healthy Finnish subjects were evaluated according to the WMS-R and scanned with positron emission tomography (PET) and dopamine D2/D3 receptor radioligand [(11)C]FLB457 for the measurement of cortical D2/D3 receptor binding.


RESULTS
WMS-R verbal memory and learning parameters did not significantly correlate with D2/D3 receptor binding potential (BP(ND)) in the studied cortical regions.


CONCLUSIONS
Our findings do not support a major role for cortical D2/D3 receptors in the regulation of verbal memory in healthy individuals.
Lumme
Ville
V
Turku PET Centre, Turku University Hospital, 20521 Turku, Finland.
Hirvonen
Mika M
MM
Ilonen
Tuula
T
Hirvonen
Jussi
J
Någren
Kjell
K
Hietala
Jarmo
J
D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D049268:Positron-Emission Tomography; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D050637:Receptors, Dopamine D3 / Q000378:metabolism*; D014705:Verbal Behavior / Q000502:physiology*; D055815:Young Adult
D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3