Role of reactive oxygen species in the progression of type 2 diabetes and atherosclerosis.
Type 2 diabetes is the most prevalent and serious metabolic disease all over the world, and its hallmarks are pancreatic beta-cell dysfunction and insulin resistance. Under diabetic conditions, chronic hyperglycemia and subsequent augmentation of reactive oxygen species (ROS) deteriorate beta-cell function and increase insulin resistance which leads to the aggravation of type 2 diabetes. In addition, chronic hyperglycemia and ROS are also involved in the development of atherosclerosis which is often observed under diabetic conditions. Taken together, it is likely that ROS play an important role in the development of type 2 diabetes and atherosclerosis.
Kaneto
Hideaki
H
Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. kaneto@endmet.med.osaka-u.ac.jp
Katakami
Naoto
N
Matsuhisa
Munehide
M
Matsuoka
Taka-aki
TA
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D050197:Atherosclerosis / Q000378:metabolism / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000473:pathology*; D018450:Disease Progression; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007249:Inflammation; D050417:Insulin-Secreting Cells / Q000166:cytology; D008954:Models, Biological; D018384:Oxidative Stress; D017382:Reactive Oxygen Species
D000975:Antioxidants; D017382:Reactive Oxygen Species; D005947:Glucose