Tissue factor microparticles and haemophilia.
Treatment choices for haemophilia patients with inhibitors are suboptimal. Tissue factor-bearing microparticles home to thrombi in a cell adhesion molecule-dependent fashion. Their potential utility as a procoagulant is discussed along with the challenges of evaluating this approach in mouse models of haemophilia.
Gross
Peter L
PL
Department of Medicine, McMaster University and the Thrombosis and Atherosclerosis Research Institute, 237 Barton Street East, Hamilton, Ontario, Canada. peter.gross@taari.ca
Vaezzadeh
Nima
N
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000378:metabolism; D006467:Hemophilia A / Q000378:metabolism*; D006487:Hemostasis; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000737:chemistry*; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D013917:Thrombin / Q000378:metabolism; D013925:Thromboplastin / Q000737:chemistry* / Q000378:metabolism
D008562:Membrane Glycoproteins; C084882:P-selectin ligand protein; D013925:Thromboplastin; D013917:Thrombin