title: Endovascular coiling of intracranial aneurysms in elderly patients: report of 205 treated aneurysms.
abstract: BACKGROUND
  More elderly patients are presenting with intracranial aneurysms. Many are poor surgical candidates and often undergo endovascular treatment.
  
  
  OBJECTIVE
  We present our experience with embolization in elderly patients.
  
  
  METHODS
  We performed a retrospective review of a prospective database of elderly patients treated with coil embolization for intracranial aneurysms.
  
  
  RESULTS
  In a period of 16 years, 205 aneurysms were treated in 196 individuals (age range, 70-96 years; mean age, 77.3 years), including 159 females (average follow-up, 16.2 months). Ninety-seven patients presented with unruptured aneurysms, and 99 patients presented after subarachnoid hemorrhage; the diagnosis was confirmed by computed tomographic scan or lumbar puncture. Complete occlusion was achieved in 53 aneurysms (26%), with a neck remnant in 127 (62%), incomplete occlusion in 13 (6%), and 12 unsuccessful attempts. Postembolization, 89.3% of patients were neurologically intact or unchanged, whereas 8.7% had new deficits. Four patients died. By modified Rankin Scale score, at last clinical evaluation, 128 patients (65%) had a good outcome. Follow-up angiograms were available for 113 aneurysms; they revealed that 62% were unchanged, 21% were further thrombosed, and 17% had recanalized. Three aneurysms ruptured after treatment during follow-up. Rupture was not associated with incomplete occlusion or neck remnant results (P = .6). Twenty-five aneurysms required reembolization. Reembolization was not associated with new deficits or death (odds ratio, 0.56; 95% confidence interval, 0.19-1.58; P = .27).
  
  
  CONCLUSIONS
  Coil embolization of intracranial aneurysms is safe and effective in the elderly. Preembolization clinical condition strongly correlates with clinical outcome. Incomplete embolizations are not associated with a higher rerupture risk. Additional embolization does not affect the clinical results.
authors.affiliation: Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California, USA. ngonzalez@mednet.ucla.edu
authors.forename: Nestor R
authors.initials: NR
authors.lastname: Gonzalez
authors.forename: Joshua R
authors.initials: JR
authors.lastname: Dusick
authors.forename: Gary
authors.initials: G
authors.lastname: Duckwiler
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tateshima
authors.forename: Reza
authors.initials: R
authors.lastname: Jahan
authors.forename: Neil A
authors.initials: NA
authors.lastname: Martin
authors.forename: Fernando
authors.initials: F
authors.lastname: Viñuela
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D017542:Aneurysm, Ruptured / Q000503:physiopathology; D002533:Cerebral Angiography; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005853:Geriatrics; D006801:Humans; D002532:Intracranial Aneurysm / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D020768:Middle Cerebral Artery / Q000473:pathology; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome