Agelastatin E, agelastatin F, and benzosceptrin C from the marine sponge Agelas dendromorpha.
The study of the n-butanol extract of the New Caledonian sponge Agelas dendromorpha led to the isolation and identification of three new pyrrole-2-aminoimidazole (P-2-AI) alkaloids, named agelastatins E (3) and F (4) and benzosceptrin C (5), together with 10 known metabolites, agelastatin A (1), agelastatin D (2), sceptrin (6), manzacidin A, tauroacidin A, taurodispacamide A, nortopsentin D, thymine, longamide, and 4,5-dibromopyrrole-2-carboxamide. Their structures were assigned by spectroscopic data interpretation. All the compounds were tested for cytotoxic activity.
Tilvi
Supriya
S
Centre de Recherche de Gif-sur-Yvette, Institut de Chimie des Substances Naturelles, UPR 2301, CNRS, Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
Moriou
Céline
C
Martin
Marie-Thérèse
MT
Gallard
Jean-François
JF
Sorres
Jonathan
J
Patel
Kirti
K
Petek
Sylvain
S
Debitus
Cécile
C
Ermolenko
Ludmila
L
Al-Mourabit
Ali
A
D047230:Agelas / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007093:Imidazoles; D007624:KB Cells; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D023303:Oxazolidinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011758:Pyrroles
D000470:Alkaloids; D007093:Imidazoles; D023303:Oxazolidinones; D011758:Pyrroles; C549719:agelastatin E; C549720:agelastatin F; C549721:benzosceptrin C