title: Application of mixture experimental design in the formulation and optimization of matrix tablets containing carbomer and hydroxy-propylmethylcellulose.
abstract: Using mixture experimental design, the effect of carbomer (Carbopol((R)) 971P NF) and hydroxypropylmethylcellulose (Methocel((R)) K100M or Methocel((R)) K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case - II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile.
authors.affiliation: Galenika a.d., Institute for Research and Development, Batajnicki drum b.b, Belgrade, Serbia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Petrovic
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Cvetkovic
authors.forename: Svetlana
authors.initials: S
authors.lastname: Ibric
authors.forename: Svetlana
authors.initials: S
authors.lastname: Trajkovic
authors.forename: Zorica
authors.initials: Z
authors.lastname: Djuric
authors.forename: Dragica
authors.initials: D
authors.lastname: Popadic
authors.forename: Radmila
authors.initials: R
authors.lastname: Popovic
mesh_terms: D000179:Acrylates / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations; D015195:Drug Design; D005079:Excipients / Q000737:chemistry*; D065347:Hypromellose Derivatives; D007700:Kinetics; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets / Q000737:chemistry*; D013806:Theophylline / Q000737:chemistry / Q000302:isolation & purification
chemical_list: D000179:Acrylates; D003692:Delayed-Action Preparations; D005079:Excipients; D013607:Tablets; C492577:carbopol 971P; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D013806:Theophylline