title: Serial angiography and intravascular ultrasound: results of the SISC Registry (Stents In Small Coronaries).
abstract: OBJECTIVE
  The aim of this study was to evaluate the novel CardioMind Sparrow (CMS) stent (CardioMind, Inc., Sunnyvale, California) against the Multi-Link Pixel (MLP) stent (Guidant Corp., Santa Clara, California) for small vessel percutaneous coronary intervention (PCI).
  
  
  BACKGROUND
  The CMS consists of a guidewire-based, self-expandable, ultra-thin nitinol stent with smaller profile and improved flexibility and deliverability. The performance of this novel device against a standard balloon-expandable stent for small vessel PCI has not been determined.
  
  
  METHODS
  Twenty-one patients were treated with the CMS and compared with 30 patients treated with MLP. Only single de novo lesions <14 mm in length, in native vessels of 2.0 to 2.5 mm were included. The primary goal was the comparison of quantitative coronary angiography lumen loss and intravascular ultrasound intimal hyperplasia (IH) formation between groups at 6 months.
  
  
  RESULTS
  Clinical characteristics were similar between groups. The CMS cohort had smaller vessels (2.20 +/- 0.20 mm vs. 2.43 +/- 0.16 mm, p < 0.0001) and shorter lesions (10.86 +/- 3.19 mm vs. 13.12 +/- 2.79 mm, p = 0.0091). Six-month late loss was significantly lower among CMS cohort (0.73 +/- 0.57 mm vs. 1.11 +/- 0.72 mm, p = 0.038). By intravascular ultrasound, 6-month IH volume was similar between groups (1.45 +/- 0.46 mm(3)/mm vs. 1.65 +/- 1.02 mm(3)/mm, p = 0.50). However, CMS presented a mean 13.39% expansion of its volumes, resulting in a significantly lower percentage of IH volumetric obstruction (31.94 +/- 8.19% vs. 39.90 +/- 4.72%, p = 0.0005).
  
  
  CONCLUSIONS
  Despite producing similar amounts of IH volume, the self-expanding CMS stent presented chronic expansion of its volumes, better accommodating the neoformed tissue and resulting in significantly lower late loss and percent of IH volumetric obstruction in comparison with the MLP stent.
authors.affiliation: Instituto Dante Pazzanese de Cardiologia, São Paulo, Brazil.
authors.forename: Daniel
authors.initials: D
authors.lastname: Chamié
authors.forename: J Ribamar
authors.initials: JR
authors.lastname: Costa
authors.forename: Alexandre
authors.initials: A
authors.lastname: Abizaid
authors.forename: Fausto
authors.initials: F
authors.lastname: Feres
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Staico
authors.forename: Fernando
authors.initials: F
authors.lastname: Devito
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Costa
authors.forename: Andréa
authors.initials: A
authors.lastname: Abizaid
authors.forename: Luiz Fernando
authors.initials: LF
authors.lastname: Tanajura
authors.forename: Amanda G M R
authors.initials: AG
authors.lastname: Sousa
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Fitzgerald
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Whitbourn
authors.forename: J Eduardo
authors.initials: JE
authors.lastname: Sousa
mesh_terms: D000497:Alloys / Q000008:administration & dosage / Q000627:therapeutic use*; D000800:Angioplasty, Balloon; D015906:Angioplasty, Balloon, Coronary; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D012042:Registries; D015607:Stents; D018084:Ultrasonography, Interventional
chemical_list: D000497:Alloys; C013616:nitinol