[Arteriosclerotic risk factors and benign prostatic hyperplasia].
OBJECTIVE
To evaluate the correlation between arteriosclerotic risk factors and the severity of benign prostatic hyperplasia (BPH).


METHODS
A total of 877 patients with diagnosed BPH were selected according to the inclusion criteria. The weight of the prostate was estimated by transrectal ultrasonography, the degree of bladder outlet obstruction determined by urodynamic examination, and the symptoms quantified by the International Prostate Symptom Score (IPSS). Arteriosclerotic risk factors included age, hypertension, dyslipidemia, type 2 diabetes mellitus, and smoking. Comparative studies were made on the data obtained by univariate and multivariate analyses.


RESULTS
The severity of BPH was increased with the increase in the severity of the risk factors and the incidence of the disease. The logistic regression analysis showed that type 2 diabetes mellitus was a prominent predictor of the prostate volume, IPSS and degree of bladder outlet obstruction (OR = 3.179, 3.862 and 2.847, P < 0.001), while the level of serum triglyceride was not (P > 0.05). Age, hypertension, high LDL, low HDL and smoking were all prominent predictors of the severity of BPH.


CONCLUSIONS
Arteriosclerotic risk factors are obviously correlated with the development and severity of BPH, among which type 2 diabetes mellitus is the most important.
Shen
Wen
W
Department of Urology, Guangzhou General Hospital of Guangzhou Military Region, Guangzhou, Guangdong 510010, China. shenxiwen27@hotmail.com
Yao
Hua-Qiang
HQ
Deng
Zhi-Xiong
ZX
Zhang
Xiao-Ming
XM
Zhang
Li-Chao
LC
Hu
Wei-Lie
WL
D000368:Aged; D000369:Aged, 80 and over; D001161:Arteriosclerosis / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000473:pathology*; D012307:Risk Factors; D001748:Urinary Bladder Neck Obstruction / Q000473:pathology