Premenstrual dysphoric disorder: neuroendocrine interferences.
Premenstrual dysphoric disorder (PMDD) consists in severe cognitive and mood changes, more aggressive as seen in premenstrual syndrome (PMS). These two syndromes are situated at the border between gynecology and psychiatry but the link between the two domains remains the neuroendocrine underlying mechanisms. In present, there are some molecular systems certainly proved as being involved, like estrogens. The hormonal pattern consists not in different levels of the hormones but different response to normal hormonal levels. The cyclical biochemical triggers are related to neurotransmitters as serotonin, endorphin and gamma-amino butyric acid (GABA). The heritability of the syndrome is sustained by genetic polymorphism in ESR1 gene. Thus, the PMDD is the result of multiple disturbances regarding neuroendocrine systems.
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Endocrinology Department, School of Medicine, "C. Davila" University of Medicine and Pharmacy Bucureşti.
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D000374:Aggression / Q000523:psychology; D015415:Biomarkers / Q000378:metabolism; D003071:Cognition; D004723:Endorphins / Q000096:biosynthesis; D047628:Estrogen Receptor alpha / Q000235:genetics; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D019964:Mood Disorders / Q000209:etiology; D010053:Ovary / Q000503:physiopathology; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D011110:Polymorphism, Genetic; D011293:Premenstrual Syndrome / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology* / Q000523:psychology*; D011569:Psychiatric Status Rating Scales; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D012307:Risk Factors; D012701:Serotonin / Q000096:biosynthesis; D018490:Serotonin Agents / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis
D015415:Biomarkers; C506487:ESR1 protein, human; D004723:Endorphins; D047628:Estrogen Receptor alpha; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D018490:Serotonin Agents; D012701:Serotonin; D005680:gamma-Aminobutyric Acid