Population pharmacokinetic modelling of repaglinide in healthy volunteers by using Non-Parametric Adaptive Grid Algorithm.
OBJECTIVE
To estimate population pharmacokinetic parameters of repaglinide in 121 healthy Malaysian volunteers.


METHODS
Each subject received 4 mg of oral repaglinide. Six blood samples were taken per individual (0, 30, 60, 120, 180 and 240 min) for repaglinide's serum concentration determination by using high-performance liquid chromatography. The parametric Iterative Two-Stage Bayesian Population Model (it2b) program followed by the Non-Parametric Adaptive Grid (npag) program was used to determine a population pharmacokinetic modelling of repaglinide.


RESULTS
Using the npag program, the mean elimination rate constant (k(el)) of repaglinide was 0.58 +/- 0.27 h and the volume of distribution (V(d)) was 23.09 +/- 9.19 L/h.


CONCLUSIONS
In this first report, specifically on the population pharmacokinetic modelling of repaglinide, the data generated should help us to better understand appropriate dosage-regimens for the drug.
Ruzilawati
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AB
Department of Pharmacology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia. tieimran@yahoo.com
Mohd Suhaimi
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AW
Gan
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SH
D000293:Adolescent; D000328:Adult; D000465:Algorithms; D015992:Body Mass Index; D002219:Carbamates / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D006801:Humans; D007004:Hypoglycemic Agents / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D008954:Models, Biological; D010880:Piperidines / Q000097:blood / Q000493:pharmacokinetics*; D055815:Young Adult
D002219:Carbamates; D007004:Hypoglycemic Agents; D010880:Piperidines; C072379:repaglinide