title: Reduced beta-catenin expression is associated with good prognosis in Astrocytoma.
abstract: The aim of this study was to evaluate the expression of beta-catenin in astrocytoma, and the clinical relevance and prognostic significance of the expression of beta-catenin was also analyzed. Immunohistochemistry was performed on 63 resected astrocytoma tumor specimens to detect the expression of beta-catenin. The correlation between the results of immuoexpression and the clinicopathologic parameters and patient survival was processed statistically. In 63 samples of astrocytoma, 36 cases were immunoreactive for beta-catenin at cytoplasm, ten cases of astrocytoma were immunoreactive at cytomembrane, and four cases of astrocytoma were stained for beta-catenin at nucleus. Spearman analysis showed that the distribution of beta-catenin was not correlated with the grades of astrocytoma. However, the expression profiles were correlated with the patient's 2-year survival, but not correlated with the grades, tumor size, sex, age, or tumor location. Patients with low beta-catenin expression levels tended to be associated with a better prognosis than those who with high levels (p = 0.042). Our results suggest that beta-catenin is useful for the prognosis evaluation of astrocytoma.
authors.affiliation: State Key Laboratory of Cancer Biology and Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Li-Ying
authors.initials: LY
authors.lastname: Zhang
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Jiang
authors.forename: Fan-Fan
authors.initials: FF
authors.lastname: Li
authors.forename: Hang
authors.initials: H
authors.lastname: Li
authors.forename: Fang
authors.initials: F
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Gu
authors.forename: Yue
authors.initials: Y
authors.lastname: Song
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Ye
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis*; D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D002648:Child; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult; D051176:beta Catenin / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D051176:beta Catenin