title: Inhibitory effects of indirubin derivatives on the growth of HL-60 leukemia cells.
abstract: Six indirubin derivatives have been synthesized and their inhibitory effects on the growth of HL-60 human promyelocytic leukemia cells investigated. Cell viability was determined using the trypan blue exclusion method. Indirubin-3'-oxime (I-1) inhibited the growth of HL-60 cells with a GI50 value of 36.6 microM, whereas I-0, I-2, I-3, I-4 and I-6 showed only weak cytotoxic activities against HL-60 cancer cells with GI50 values in the range of 97.3 to over 100 microM. These results indicate that indirubin derivatives might be useful candidate agents for exploring potential antileukemic drugs.
authors.affiliation: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Rd, Caugiay, Hanoi, Vietnam. nmcuong_inpc@yahoo.com.vn
authors.forename: Nguyen Manh
authors.initials: NM
authors.lastname: Cuong
authors.forename: Bui Huu
authors.initials: BH
authors.lastname: Tai
authors.forename: Dang Hoang
authors.initials: DH
authors.lastname: Hoan
authors.forename: Tran Thu
authors.initials: TT
authors.lastname: Huong
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
authors.forename: Jae-Hee
authors.initials: JH
authors.lastname: Hyun
authors.forename: Hee-Kyoung
authors.initials: HK
authors.lastname: Kang
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D007211:Indoles; C027185:indirubin