Most efficient routes for the synthesis of alpha,beta-diamino acid-derived compounds.
Alpha,beta-Diamino acids have attracted considerable attention recently due to their growing importance in pharmaceutical and biochemical research. For example, this special class of alpha,beta-diamino acids has become the components of enzyme inhibitors, and has been incorporated into peptides which are used to modulate secondary and tertiary structural conformations. Although their widely occurrence in nature, optically active diamino acids are hard to isolate and purify from available natural resources on large scale. Therefore, their asymmetric synthesis becomes a great interest for organic and medicinal chemists. However, there still exist great challenges for enantioselective synthesis of diamino acids, especially those with two vicinal chiral centers. This review highlights the recent promising methodologies for enantioselective synthesis of alpha,beta-diamino acids, with special emphasis on catalytic asymmetric reactions, as well as methods for natural chiral compound derivatization, and chiral auxiliaries.
Wang
Jiang
J
Center for Drug Discovery and Design, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, PR China.
Zhang
Lei
L
Jiang
Hualiang
H
Liu
Hong
H
D000599:Amino Acids, Diamino / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D013237:Stereoisomerism
D000599:Amino Acids, Diamino