title: Diverse DNA-cleaving capacities of the jadomycins through precursor-directed biosynthesis.
abstract: Gel mobility assays were used to establish that some members of the jadomycin family of natural products act as DNA cleaving agents. Moreover, it was found that subtle structural changes generated through the use of precursor-directed biosynthesis lead to marked effects on the DNA-damaging properties of these glycosylated polyketide-derived natural products.
authors.affiliation: Chemistry Department, Acadia University, Wolfville, NS B4P 2R6, Canada.
authors.forename: Krista M
authors.initials: KM
authors.lastname: Cottreau
authors.forename: Colin
authors.initials: C
authors.lastname: Spencer
authors.forename: Jason R
authors.initials: JR
authors.lastname: Wentzell
authors.forename: Cathy L
authors.initials: CL
authors.lastname: Graham
authors.forename: Charles N
authors.initials: CN
authors.lastname: Borissow
authors.forename: David L
authors.initials: DL
authors.lastname: Jakeman
authors.forename: Sherri A
authors.initials: SA
authors.lastname: McFarland
mesh_terms: D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D053837:DNA Cleavage; D004249:DNA Damage; D007546:Isoquinolines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000378:metabolism; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D007546:Isoquinolines; D009285:Naphthoquinones; C506597:jadomycin A; C081750:jadomycin B; D004247:DNA