title: An amine-derivatized, DOTA-loaded polymeric support for Fmoc Solid Phase Peptide Synthesis.
abstract: An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional Solid Phase Peptide Synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast agent. Therefore, this synthesis methodology can facilitate Fmoc SPPS of molecular imaging contrast agents.
authors.affiliation: Biomedical Engineering Interdisciplinary Program, The University of Arizona, Tucson AZ.
authors.forename: Byunghee
authors.initials: B
authors.lastname: Yoo
authors.forename: Vipul R
authors.initials: VR
authors.lastname: Sheth
authors.forename: Mark D
authors.initials: MD
authors.lastname: Pagel