title: Exercise plays a preventive role against Alzheimer's disease.
abstract: Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting the elderly population. It is predicted that the incidence of AD will be increased in the future making this disease one of the greatest medical, social, and economic challenges for individuals, families, and the health care system worldwide. The etiology of AD is multifactorial. It features increased oxidative state and deposition of amyloid plaques and neurofibrillary tangles of protein tau in the central cortex and limbic system of the brain. Here we provide an overview of the positive impacts of exercise on this challenging disease. Regular physical activity increases the endurance of cells and tissues to oxidative stress, vascularization, energy metabolism, and neurotrophin synthesis, all important in neurogenesis, memory improvement, and brain plasticity. Although extensive studies are required to understand the mechanism, it is clear that physical exercise is beneficial in the prevention of AD and other age-associated neurodegenerative disorders.
authors.affiliation: Research Institute of Sport Science, Faculty of Physical Education and Sport Science, Semmelweis University, Budapest, Hungary. radak@mail.hupe.hu
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Radak
authors.forename: Nikoletta
authors.initials: N
authors.lastname: Hart
authors.forename: Linda
authors.initials: L
authors.lastname: Sarga
authors.forename: Erika
authors.initials: E
authors.lastname: Koltai
authors.forename: Mustafa
authors.initials: M
authors.lastname: Atalay
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohno
authors.forename: Istvan
authors.initials: I
authors.lastname: Boldogh
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology; D015444:Exercise / Q000502:physiology*; D006801:Humans; D009414:Nerve Growth Factors / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D009414:Nerve Growth Factors