Critical pneumonia complicating early-stage pregnancy.
We present a case of community-acquired methicillin-resistant Staphylococcus aureus necrotizing pneumonia, Panton-Valentine leukocidin positive, in a woman at 14 weeks of pregnancy. To our knowledge, this is the first case reporting this critical lung infection occurring during an early phase of pregnancy. This case study alerts physicians to the increasing worldwide spread of these uncommon yet virulent and potentially lethal infections. In our patient, antibiotic therapy with linezolid plus rifampin started at 14 weeks of pregnancy had a successful outcome without inducing toxicity or teratogenesis in the fetus.
Mercieri
Marco
M
Università Sapienza di Roma, II Facoltà di Medicina e Chirurgia, Ospedale Sant'Andrea, via di Grottarossa 1035, Rome, Italy. mamerx@gmail.com
Di Rosa
Roberta
R
Pantosti
Annalisa
A
De Blasi
Roberto Alberto
RA
Pinto
Giovanni
G
Arcioni
Roberto
R
D000081:Acetamides / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000378:metabolism; D004359:Drug Therapy, Combination; D005098:Exotoxins / Q000378:metabolism; D005260:Female; D006801:Humans; D007956:Leukocidins / Q000378:metabolism; D000069349:Linezolid; D008168:Lung / Q000000981:diagnostic imaging / Q000187:drug effects / Q000382:microbiology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification* / Q000378:metabolism; D009336:Necrosis; D023303:Oxazolidinones / Q000627:therapeutic use; D011023:Pneumonia, Staphylococcal / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology*; D011261:Pregnancy Trimester, First; D011859:Radiography; D012293:Rifampin / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
D000081:Acetamides; D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; D023303:Oxazolidinones; C078284:Panton-Valentine leukocidin; D000069349:Linezolid; D012293:Rifampin