title: A new C29-sterol with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge lanthella sp.
abstract: One new C(29) sterol with a cyclopropane ring at C-25 and C-26, aragusteroketal B (1), and aragusterol B (2) were isolated from the Vietnamese marine sponge Ianthella sp. Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic activity against MCF-7, SK-Hep-1, and HeLa cell lines with IC(50) in the range of 12.8-27.8 microM.
authors.affiliation: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Vietnam.
authors.forename: Nguyen Huu
authors.initials: NH
authors.lastname: Tung
authors.forename: Chau
authors.initials: C
authors.lastname: Van Minh
authors.forename: Phan
authors.initials: P
authors.lastname: Van Kiem
authors.forename: Hoang Thanh
authors.initials: HT
authors.lastname: Huong
authors.forename: Tran Thu
authors.initials: TT
authors.lastname: Ha
authors.forename: Nguyen Tien
authors.initials: NT
authors.lastname: Dat
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Nhiem
authors.forename: Nguyen Xuan
authors.initials: NX
authors.lastname: Cuong
authors.forename: Jae-Hee
authors.initials: JH
authors.lastname: Hyun
authors.forename: Hee-Kyoung
authors.initials: HK
authors.lastname: Kang
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002852:Chromatography, Ion Exchange; D002855:Chromatography, Thin Layer; D004396:Coloring Agents; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013778:Tetrazolium Salts; D013844:Thiazoles; D014744:Vietnam
chemical_list: D000970:Antineoplastic Agents; D004396:Coloring Agents; D007202:Indicators and Reagents; D013261:Sterols; D013778:Tetrazolium Salts; D013844:Thiazoles; C549416:aragusteroketal B; C022616:thiazolyl blue