title: Mineral trioxide aggregate: a comprehensive literature review--Part III: Clinical applications, drawbacks, and mechanism of action.
abstract: BACKGROUND
  Mineral trioxide aggregate (MTA) has been recommended for various uses in endodontics. Two previous publications provided a comprehensive list of articles from November 1993-September 2009 regarding the chemical and physical properties, sealing ability, antibacterial activity, leakage, and biocompatibility of MTA. The purpose of Part III of this literature review is to present a comprehensive list of articles regarding animal studies, clinical applications, drawbacks, and mechanism of action of MTA.
  
  
  METHODS
  A review of the literature was performed by using electronic and hand-searching methods for the clinical applications of MTA in experimental animals and humans as well as its drawbacks and mechanism of action from November 1993-September 2009.
  
  
  RESULTS
  MTA is a promising material for root-end filling, perforation repair, vital pulp therapy, and apical barrier formation for teeth with necrotic pulps and open apexes. Despite the presence of numerous case reports and case series regarding these applications, there are few designed research studies regarding clinical applications of this material. MTA has some known drawbacks such as a long setting time, high cost, and potential of discoloration. Hydroxyapatite crystals form over MTA when it comes in contact with tissue synthetic fluid. This can act as a nidus for the formation of calcified structures after the use of this material in endodontic treatments.
  
  
  CONCLUSIONS
  On the basis of available information, it appears that MTA is the material of choice for some clinical applications. More clinical studies are needed to confirm its efficacy compared with other materials.
authors.affiliation: Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
authors.forename: Masoud
authors.initials: M
authors.lastname: Parirokh
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Torabinejad
mesh_terms: D017607:Aluminum Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D000818:Animals; D017610:Calcium Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D003785:Dental Pulp Capping / Q000379:methods*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D006801:Humans; D023421:Models, Animal; D010087:Oxides / Q000009:adverse effects / Q000627:therapeutic use*; D012387:Root Canal Filling Materials / Q000009:adverse effects / Q000627:therapeutic use*; D017640:Silicates / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate