Nucleoside analog ARC targets Mcl-1 to induce apoptosis in leukemia cells.
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D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001713:Biphenyl Compounds / Q000494:pharmacology; D061945:Caspase Inhibitors; D020169:Caspases / Q000378:metabolism; D004357:Drug Synergism; D006801:Humans; D015151:Immunoblotting; D007938:Leukemia / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D009596:Nitrophenols / Q000494:pharmacology; D009705:Nucleosides / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D011743:Pyrimidines / Q000494:pharmacology*; D013449:Sulfonamides / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C509961:4-amino-6-hydrazino-7-beta-D-ribofuranosyl-7H-pyrrolo(2,3-d)-pyrimidine-5-carboxamide; C501332:ABT-737; D000970:Antineoplastic Agents; D001713:Biphenyl Compounds; D061945:Caspase Inhibitors; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D009596:Nitrophenols; D009705:Nucleosides; D010879:Piperazines; D019253:Proto-Oncogene Proteins c-bcl-2; D011743:Pyrimidines; D013449:Sulfonamides; D020169:Caspases