T-cell cytokine production and endothelial dysfunction in type 2 diabetic patients with nephropathy.
This study assessed changes in serum levels of cytokines IFNgamma and IL-10 (biomarkers of inflammatory changes) and soluble biomarkers sICAM-1 and sE-selectin (biomarkers of endothelial dysfunction) in diabetic patients with and without nephropathy. IFNgamma and IL-10 were significantly elevated in patients with diabetic nephropathy (DN) and end-stage renal disease (ESRD) compared with controls and diabetic patients without DN. IFNgamma and IL-10 levels were significantly increased after haemodialysis. sICAM-1 and sE-selectin were significantly higher in diabetic, DN and ESRD groups compared with controls, and sICAM-1 but not sE-selectin was increased after haemodialysis.
Kamel
L
L
Department of Clinical Chemistry, Theodor Bilharz Research Institute, Cairo, Egypt. kmlaila@yahoo.com
Morsy
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A
El Shamaa
A
A
D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001772:Blood Cell Count; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000276:immunology*; D003928:Diabetic Nephropathies / Q000097:blood / Q000150:complications / Q000276:immunology*; D019040:E-Selectin / Q000097:blood*; D004534:Egypt; D006801:Humans; D007249:Inflammation; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000276:immunology* / Q000628:therapy; D007677:Kidney Function Tests; D008111:Liver Function Tests; D008875:Middle Aged; D006435:Renal Dialysis; D018709:Statistics, Nonparametric; D013601:T-Lymphocytes / Q000276:immunology*
D015415:Biomarkers; D019040:E-Selectin; D018799:Intercellular Adhesion Molecule-1; D016753:Interleukin-10; D007371:Interferon-gamma