title: Blood lipids, homocysteine, stress factors, and vitamins in clinically stable multiple sclerosis patients.
abstract: Multiple Sclerosis (MS) patients present a decrease of antioxidants and neuroprotective and immunoregulatory vitamins and an increase of total homocysteine (tHcy), cholesterol (CHL), HDL-cholesterol, and of cellular stress markers, variably associated with the different phases of the disease. We compared the blood levels of uric acid, folic acid, vitamins B12, A, and E, tHcy, CHL, HDL-cholesterol, and triglycerides in forty MS patients during a phase of clinical inactivity with those of eighty healthy controls, matched for age and sex. We found higher levels of tHcy (p = 0.032) and of HDL-cholesterol (p = 0.001) and lower levels of vitamin E (p = 0.001) and the ratio vitamin E/CHL (p = 0.001) in MS patients. In conclusion, modifications of some biochemical markers of cell damage were detected in MS patients during a phase of clinical inactivity.
authors.affiliation: Department of Clinical Neuroscience, University of Palermo, Palermo, Italy. gsalemi@neomedia.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Salemi
authors.forename: Maria Concetta
authors.initials: MC
authors.lastname: Gueli
authors.forename: Francesco
authors.initials: F
authors.lastname: Vitale
authors.forename: Floriana
authors.initials: F
authors.lastname: Battaglieri
authors.forename: Egidio
authors.initials: E
authors.lastname: Guglielmini
authors.forename: Paolo
authors.initials: P
authors.lastname: Ragonese
authors.forename: Angela
authors.initials: A
authors.lastname: Trentacosti
authors.forename: Maria Fatima
authors.initials: MF
authors.lastname: Massenti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Savettieri
authors.forename: Antonino
authors.initials: A
authors.lastname: Bono
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000737:chemistry; D016022:Case-Control Studies; D005260:Female; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood; D014815:Vitamins / Q000097:blood*
chemical_list: D000975:Antioxidants; D008055:Lipids; D014280:Triglycerides; D014815:Vitamins; D006710:Homocysteine; D014527:Uric Acid; D005492:Folic Acid