title: Synthesis and characterization of novel multiphase bioactive glass-ceramics in the CaO-MgO-SiO(2) system.
abstract: Three new chemical compositions based on the CaO-MgO-SiO(2) system were designed first, and then three novel glass-ceramics (M1, M2, and M3) were prepared by sol-gel method. X-ray diffraction analysis confirmed that they were predominantly composed of akermanite, wollastonite, and dicalcium silicate crystalline phases. The coefficient of thermal expansion (CTE) of M2 was 10.79 x 10(-6) degrees C(-1), closest to that of Ti-6Al-4V alloy, and the Young's modulus of M2 was 29.73 GPa, similar to that of the cortical bone. The bioactivity in vitro of M2 was evaluated by investigating its bonelike hydroxyapatite (HA)-formation ability in simulated body fluid (SBF), and the biocompatibility in vitro was detected by osteoblast proliferation, differentiation, and adhesion assay. The results revealed that M2 possessed bonelike carbonated hydroxyapatite (CHA)-formation ability in SBF and could significantly stimulate cell proliferation and differentiation. Furthermore, osteoblasts adhered and spread well on M2, indicating good bioactivity and biocompatibility in vitro.
authors.affiliation: College of Materials Science and Engineering, Sichuan University, Chengdu 610064, People's Republic of China.
authors.forename: Xianchun
authors.initials: X
authors.lastname: Chen
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Liao
authors.forename: Zhongbing
authors.initials: Z
authors.lastname: Huang
authors.forename: Panli
authors.initials: P
authors.lastname: You
authors.forename: Chun
authors.initials: C
authors.lastname: Chen
authors.forename: Yunqing
authors.initials: Y
authors.lastname: Kang
authors.forename: Guangfu
authors.initials: G
authors.lastname: Yin
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000497:Alloys; D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry*; D001696:Biomechanical Phenomena; D018786:Bone Substitutes / Q000138:chemical synthesis / Q000737:chemistry; D017610:Calcium Compounds / Q000737:chemistry; D002448:Cell Adhesion; D002454:Cell Differentiation; D049109:Cell Proliferation; D048430:Cell Shape; D002516:Ceramics / Q000138:chemical synthesis* / Q000737:chemistry*; D066298:In Vitro Techniques; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D010006:Osteoblasts / Q000166:cytology / Q000502:physiology; D010070:Oxalates / Q000737:chemistry; D010087:Oxides / Q000737:chemistry; D044367:Phase Transition; D051381:Rats; D012822:Silicon Dioxide / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D014025:Titanium; D014961:X-Ray Diffraction
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D018786:Bone Substitutes; D017610:Calcium Compounds; D010070:Oxalates; D010087:Oxides; C031462:titanium alloy (TiAl6V4); D012822:Silicon Dioxide; C023506:Glass ceramics; C016538:lime; D014025:Titanium; D000469:Alkaline Phosphatase