title: Evaluating the performance of serum antimullerian hormone concentration in predicting the live birth rate of controlled ovarian stimulation and intrauterine insemination.
abstract: OBJECTIVE
  To evaluate the role of serum antimullerian hormone (AMH) concentration in predicting live birth outcome in controlled ovarian stimulation and intrauterine insemination (IUI).
  
  
  METHODS
  Retrospective analysis.
  
  
  METHODS
  Tertiary assisted reproduction unit.
  
  
  METHODS
  243 patients undergoing IUI treatment.
  
  
  METHODS
  Archived early follicular phase serum samples taken at the start of the first treatment cycle before ovarian stimulation were retrieved from patients undergoing IUI treatment.
  
  
  METHODS
  First-cycle and cumulative live birth rates.
  
  
  RESULTS
  Patients attaining a successful live birth, either in the first cycle or cumulatively after three cycles, had significantly higher serum AMH concentrations than those failing treatment. Serum AMH concentration correlated positively with antral follicle count (AFC) and duration of stimulation and inversely with maternal age, serum FSH concentration, and total dose of gonadotropin used. After controlling for age, body mass index, AFC, and FSH, AMH remained the only significant predictor of cumulative live birth. The area under the receiver operating characteristic curve was 0.668 in predicting cumulative live birth. Serum AMH concentration was significantly higher in overresponders.
  
  
  CONCLUSIONS
  Serum AMH concentration was significantly higher in subjects with a live birth from the first cycle or after three cycles of stimulated IUI treatment compared with those failing treatment. Serum AMH concentration has a modest predictive value on ovarian overresponse.
authors.affiliation: Centre of Assisted Reproduction and Embryology, Department of Obstetrics and Gynaecology, University of Hong Kong, Queen Mary Hospital, Hong Kong. raymondli@hkucc.hku.hk
authors.forename: Hang Wun Raymond
authors.initials: HW
authors.lastname: Li
authors.forename: William Shu Biu
authors.initials: WS
authors.lastname: Yeung
authors.forename: Estella Yee Lan
authors.initials: EY
authors.lastname: Lau
authors.forename: Pak Chung
authors.initials: PC
authors.lastname: Ho
authors.forename: Ernest Hung Yu
authors.initials: EH
authors.lastname: Ng
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000032:analysis / Q000097:blood*; D004526:Efficiency; D005260:Female; D006801:Humans; D007246:Infertility / Q000097:blood / Q000175:diagnosis* / Q000628:therapy; D007315:Insemination, Artificial / Q000379:methods; D050498:Live Birth; D016471:Ovarian Hyperstimulation Syndrome / Q000175:diagnosis; D010062:Ovulation Induction / Q000009:adverse effects / Q000379:methods; D011237:Predictive Value of Tests; D011247:Pregnancy; D018873:Pregnancy Rate; D011379:Prognosis; D012189:Retrospective Studies; D014599:Uterus
chemical_list: D054304:Anti-Mullerian Hormone