title: Synthesis of chiral 3-alkyl-3,4-dihydroisocoumarins by dynamic kinetic resolutions catalyzed by a Baeyer-Villiger monooxygenase.
abstract: Baeyer-Villiger monooxygenases have been tested in the oxidation of racemic benzofused ketones. When employing a single mutant of phenylacetone monooxygenase (M446G PAMO) under the proper reaction conditions, it was possible to achieve 3-substituted 3,4-dihydroisocoumarins with high yields and optical purities through regioselective dynamic kinetic resolution processes.
authors.affiliation: Departamento de Química Orgánica e Inorgánica, Instituto de Biotecnología de Asturias, Universidad de Oviedo, 33006, Oviedo, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Rioz-Martínez
authors.forename: Gonzalo
authors.initials: G
authors.lastname: de Gonzalo
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Torres Pazmiño
authors.forename: Marco W
authors.initials: MW
authors.lastname: Fraaije
authors.forename: Vicente
authors.initials: V
authors.lastname: Gotor
mesh_terms: D002384:Catalysis; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry; D007700:Kinetics; D006899:Mixed Function Oxygenases / Q000737:chemistry* / Q000235:genetics; D008958:Models, Molecular; D015394:Molecular Structure; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics; D013237:Stereoisomerism
chemical_list: D003374:Coumarins; D011994:Recombinant Proteins; D006899:Mixed Function Oxygenases