title: Distinguishing the viability of a single yeast cell with an ultra-sensitive radio frequency sensor.
abstract: We propose and demonstrate a simple, ultra sensitive radio frequency (RF) sensor to detect a single yeast cell and distinguish its viability in a microfluidic channel. On-chip interference is used to cancel background probing signals to improve sensor sensitivity. Individual viable and nonviable yeast cells (approximately 5.83 +/- 0.85 microm in diameter) are measured with clear sensing and identification of these cells.
authors.affiliation: Department of Electrical and Computer Engineering, Clemson University, Clemson, South Carolina 29634, USA. yang6@clemson.edu
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Hanqiao
authors.initials: H
authors.lastname: Zhang
authors.forename: Junjie
authors.initials: J
authors.lastname: Zhu
authors.forename: Gaoyan
authors.initials: G
authors.lastname: Wang
authors.forename: Tzuen-Rong
authors.initials: TR
authors.lastname: Tzeng
authors.forename: Xiangchun
authors.initials: X
authors.lastname: Xuan
authors.forename: Kama
authors.initials: K
authors.lastname: Huang
authors.forename: Pingshan
authors.initials: P
authors.lastname: Wang
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation*; D002470:Cell Survival / Q000502:physiology* / Q000528:radiation effects; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005434:Flow Cytometry / Q000295:instrumentation*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D011846:Radio Waves; D015203:Reproducibility of Results; D012441:Saccharomyces cerevisiae / Q000502:physiology* / Q000528:radiation effects; D012680:Sensitivity and Specificity