A bird's-eye view of MeCP2 binding.
In this issue of Molecular Cell, work from Skene, Bird, and colleagues reexamines MeCP2 function in the brain by characterizing the abundance and distribution of MeCP2 protein in mouse neurons and its role in regulating chromatin structure (Skene et al., 2010).
Cohen
Sonia
S
Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
Greenberg
Michael E
ME
D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D051783:Methyl-CpG-Binding Protein 2 / Q000172:deficiency / Q000378:metabolism*; D051379:Mice; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D011485:Protein Binding; D055503:Protein Multimerization
D002843:Chromatin; D006657:Histones; C497393:Mecp2 protein, mouse; D051783:Methyl-CpG-Binding Protein 2