Use of normal tissue complication probability models in the clinic.
The Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) review summarizes the currently available three-dimensional dose/volume/outcome data to update and refine the normal tissue dose/volume tolerance guidelines provided by the classic Emami et al. paper published in 1991. A "clinician's view" on using the QUANTEC information in a responsible manner is presented along with a description of the most commonly used normal tissue complication probability (NTCP) models. A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included.
Marks
Lawrence B
LB
Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27514, USA. marks@med.unc.edu
Yorke
Ellen D
ED
Jackson
Andrew
A
Ten Haken
Randall K
RK
Constine
Louis S
LS
Eisbruch
Avraham
A
Bentzen
Søren M
SM
Nam
Jiho
J
Deasy
Joseph O
JO
D000328:Adult; D002648:Child; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D009928:Organ Specificity; D017410:Practice Guidelines as Topic; D011832:Radiation Injuries / Q000517:prevention & control*; D018787:Radiation Oncology; D011836:Radiation Tolerance