[Expression of GLUT 3 in different brain regions of aged rats].
To examine the distribution of glucose transport 3 (GLUT 3) in different brain regions of aged rats and to investigate its role in ageing process of the nervous system.



The GLUT 3 expression in different brain regions was examined with immunohistochemical method in rats aged 3, 18 and 30 months, respectively.



The number of GLUT 3-positive cells varied in the different brain regions in rats of all age groups (P<0.01); the CA1 region contained the greatest number of positive cells,and fewer in the motor cortex and cerebellum. The number of GLUT 3-positive cells was reduced in the brain of aged rats (P<0.01); and the neural cells in 4 different brain regions presented with large cell body and loose alignment.



The expression of GLUT 3 decreased in aged rats, which suggests that GLUT 3 may be involved in the ageing process of nervous system.
Wu
Hai-qin
HQ
Department of Neurology, The Second Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, China. whq60@sohu.com
Sha
Juan-juan
JJ
Wang
Hu-qing
HQ
Ren
Bei
B
Zhang
Gui-lian
GL
Li
Ming
M
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D051274:Glucose Transporter Type 3 / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D051274:Glucose Transporter Type 3; C495690:Slc2a3 protein, rat