title: Coagulation studies in patients with orthopedic trauma.
abstract: BACKGROUND
  Head injury, severe acidosis, hypothermia, massive transfusion and hypoxia often complicate traumatic coagulopathy. First line investigations such as prothrombin time, activated partial thromboplastin time, thrombin time, fibrinogen level, platelet count and D-dimer levels help in the initial assessment of coagulopathy in a trauma victim.
  
  
  OBJECTIVE
  To study the coagulation profile in patients of orthopedic trauma.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Patients with head injury, severe acidosis, massive transfusion and severe hypoxia were excluded from the study. Coagulation parameters were evaluated at three intervals, at the time of admission, intra operatively and in the postoperative period.
  
  
  METHODS
  Chi-square test was used for analysis of categorical variables. For comparison between groups, two- way ANOVA was used.
  
  
  CONCLUSIONS
  Of the 48 patients studied, 38 (80%) had normal DIC scores upon admission and only 10 (20%) had mild DIC scores at the time of admission. The median Injury Severity Score was 34 and they did not correlate with DIC scores. Fibrinogen levels alone were significantly different, increased progressively (mean pre op, intra op and post op levels 518 +/- 31,582 +/- 35 and 643 +/- 27 respectively; P </= 0.02) since the time of admission in these patients. All the other parameters remained unchanged. Further large scale prospective studies would be required to correlate elevated fibrinogen levels with the type of trauma or surgery.
authors.affiliation: Department of Laboratory Medicine, Jai Prakash Narayan Apex Trauma Centre, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Kanchana
authors.initials: K
authors.lastname: Rangarajan
authors.forename: Arulselvi
authors.initials: A
authors.lastname: Subramanian
authors.forename: Jatin S
authors.initials: JS
authors.lastname: Gandhi
authors.forename: Namit
authors.initials: N
authors.lastname: Saraf
authors.forename: Vijay
authors.initials: V
authors.lastname: Sharma
authors.forename: Kamran
authors.initials: K
authors.lastname: Farooque