Toward a practical and waste-free synthesis of thioureas in water.
An operationally simple and entirely green protocol for the synthesis of thiourea derivatives by the reaction of carbon disulfide with primary amines in pure water is developed. This reaction is a highly atom-economic process for production of highly pure, hindered thioureas without any catalyst and tedious work-up.
Azizi
Najmedin
N
Research and Technology, Chemistry and Chemical Engineering Research Center of Iran, P.O. Box 14335-186, Tehran, Iran. azizi@ccerci.ac.ir
Khajeh-Amiri
Alireza
A
Ghafuri
Hossein
H
Bolourtchian
Mohammad
M
D055808:Drug Discovery; D055772:Green Chemistry Technology / Q000379:methods*; D013890:Thiourea / Q000138:chemical synthesis*; D014867:Water / Q000737:chemistry*
D014867:Water; D013890:Thiourea