Programing the formation of DNA and PNA quadruplexes by pi-pi-stacking interactions.
Guanine (G) rich G(4)T(4)G(4) DNA and homologous PNA strands tend to form antiparallel dimeric quadruplexes. In contrast, the same DNA strands carrying planar aromatic 5'-residues preferentially form parallel DNA quadruplex. Conformation and composition of the DNA quadruplexes can be programed by pi-pi-stacking interaction exerted by the 5'-residues.
Saha
Sourav
S
Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107, USA.
Cai
Jianfeng
J
Eiler
Daniel
D
Hamilton
Andrew D
AD
D020029:Base Pairing; D001483:Base Sequence; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D054856:G-Quadruplexes; D020135:Peptide Nucleic Acids / Q000737:chemistry* / Q000235:genetics
D020135:Peptide Nucleic Acids; D004247:DNA