title: The uptake by blood-borne phagocytes of monosodium urate is dependent on heat-labile serum factor(s) and divalent cations.
abstract: Accumulation in tissues of post-apoptotic cells is a feature frequently observed in patients with systemic lupus erythematosus and in murine models of systemic autoimmune diseases. One of the endogenous danger molecules released by secondarily necrotic cells is monosodium urate (MSU), which is already established to be the causative agent of gout. Here, we show that MSU is taken up by eosinophils, neutrophils and monocytes in a process involving (a) heat-labile serum factor(s) and divalent cations. The uptake induces the release of the pro-inflammatory cytokines IL-1beta/IL-18/TNFalpha and IL-6/IL-8 by monocytes and PMN, respectively.
authors.affiliation: Deparment for Internal Medicine 3, Friedrich-Alexander University of Erlangen-Nürnberg, Erlangen, Germany.
authors.forename: Christine
authors.initials: C
authors.lastname: Schorn
authors.forename: Moritz
authors.initials: M
authors.lastname: Strysio
authors.forename: Christina
authors.initials: C
authors.lastname: Janko
authors.forename: Luis E
authors.initials: LE
authors.lastname: Munoz
authors.forename: Georg
authors.initials: G
authors.lastname: Schett
authors.forename: Martin
authors.initials: M
authors.lastname: Herrmann
mesh_terms: D002413:Cations, Divalent / Q000097:blood / Q000276:immunology; D016207:Cytokines / Q000276:immunology*; D006073:Gout / Q000097:blood / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology*; D010586:Phagocytes / Q000276:immunology* / Q000378:metabolism; D014527:Uric Acid / Q000097:blood* / Q000276:immunology
chemical_list: D002413:Cations, Divalent; D016207:Cytokines; D014527:Uric Acid