Solid-phase synthesis of peptide-viologen conjugates.
This paper presents a robust method for the conjugation of viologens to peptides using an amide coupling strategy that is compatible with standard Fmoc solid-phase peptide synthesis. Methodology is presented for monitoring the milligram scale process quantitatively by UV spectroscopy. This chemistry enables the synthesis of a broad range of asymmetric viologens in high yield at room temperature and is compatible with a wide range of functional groups, including amine, guanidinyl, thiol, carboxylic acid, phenol, and indole.
Reczek
Joseph J
JJ
Department of Chemistry, Trinity University, San Antonio, Texas 78212, USA.
Rebolini
Elisa
E
Urbach
Adam R
AR
D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D014755:Viologens / Q000138:chemical synthesis* / Q000737:chemistry
D010455:Peptides; D014755:Viologens