title: Molecular therapeutic approaches to melanoma.
abstract: Metastatic melanoma is a highly lethal cancer that has historically been refractory to all tested pharmacological agents. An understanding of the mechanisms responsible for its oncogenesis is critical for developing successful therapies. An enormous amount of data generated over the last few decades have revealed important biological insights into melanoma initiation, progression and maintenance, which bring new directions and approaches to treatment of this devastating skin cancer.
authors.affiliation: Wellman Center for Photomedicine/Dept of Dermatology, 55 Fruit Street, Boston, MA 02114, USA.
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Ji
authors.forename: Keith T
authors.initials: KT
authors.lastname: Flaherty
authors.forename: Hensin
authors.initials: H
authors.lastname: Tsao
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000970:Antineoplastic Agents