title: High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns.
abstract: The objective was to explain the discrepancy in the development of hypoxic ischemic brain injury (HIE) in some asphyxiated newborns rather than others. Forty newborns were classified according to their cerebrospinal neuron-specific-enolase (CSF-NSE) levels on their 5th-day of life; group 1 with low-NSE (n = 25). The remaining 15 newborns had high-NSE and were further divided into a group with no HIE (n = 10, group 2) and another with HIE (n = 5, group 3). CSF-NSE, total-hydroperoxide (TH), biological-antioxidant-potentials (BAPs), 12 cytokines and erythropoietin (EPO) were measured. The TH/BAP gave the oxidative-stress-index (OSI). The BAPs of serial dilutions of three types of EPO were tested. CSF-NSE and TH and mean OSIs were higher in group 3. IL-8 and mean BAPs were higher in group 2 than in group 1. EPO was less detected in group 3. Serial EPO dilutions correlated with their BAPs. Compensatory antioxidants and IL-8 elevation could be protective of perinatal asphyxic brain injury. Antioxidative effect of EPO could be neuroprotective.
authors.affiliation: Department of Pediatric Surgery and Liver Transplantation, Fujita Health University School of Medicine, Aichi, Japan. hamed@fujita-hu.ac.jp
authors.forename: Mohamed Hamed
authors.initials: MH
authors.lastname: Hussein
authors.forename: Ghada A
authors.initials: GA
authors.lastname: Daoud
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kakita
authors.forename: Shin
authors.initials: S
authors.lastname: Kato
authors.forename: Tatenobu
authors.initials: T
authors.lastname: Goto
authors.forename: Michi
authors.initials: M
authors.lastname: Kamei
authors.forename: Kenji
authors.initials: K
authors.lastname: Goto
authors.forename: Masanori
authors.initials: M
authors.lastname: Nobata
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Ozaki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ito
authors.forename: Sumio
authors.initials: S
authors.lastname: Fukuda
authors.forename: Ineko
authors.initials: I
authors.lastname: Kato
authors.forename: Satoshi
authors.initials: S
authors.lastname: Suzuki
authors.forename: Hisanori
authors.initials: H
authors.lastname: Sobajima
authors.forename: Fujio
authors.initials: F
authors.lastname: Hara
authors.forename: Takashi
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Hajime
authors.initials: H
authors.lastname: Togari
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D001212:Asialoglycoproteins / Q000378:metabolism; D001238:Asphyxia Neonatorum / Q000134:cerebrospinal fluid / Q000150:complications* / Q000276:immunology; D004921:Erythropoietin / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid / Q000378:metabolism; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000134:cerebrospinal fluid; D002534:Hypoxia, Brain / Q000134:cerebrospinal fluid / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D007231:Infant, Newborn; D016209:Interleukin-8 / Q000134:cerebrospinal fluid*; D008297:Male; D018384:Oxidative Stress; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid; D011994:Recombinant Proteins; D015854:Up-Regulation
chemical_list: D000975:Antioxidants; D001212:Asialoglycoproteins; C508606:CXCL8 protein, human; D016209:Interleukin-8; D011994:Recombinant Proteins; C500605:asialoerythropoietin; D004921:Erythropoietin; D006861:Hydrogen Peroxide; D010751:Phosphopyruvate Hydratase