Association of diabetes susceptibility gene calpain-10 with pancreatic cancer among smokers.
OBJECTIVE
The objective of this study was to test the association between calpain-10 (CAPN10), a diabetes susceptibility gene, with risk of pancreatic cancer (PC).


METHODS
DNA samples from 83 incident exocrine PC cases and 166 controls, all of whom were smokers, were genotyped for four markers of CAPN10 in a nested case-control study based on the Beta-Carotene and Retinol Efficacy Trial (CARET), a randomized chemoprevention trial of subjects at high risk of lung cancer. Controls were matched on sex, race, age, CARET intervention arm, duration of exposure to asbestos, and smoking history. Conditional logistic regression was used for statistical analyses.


RESULTS
The minor allele of SNP-43 (rs3792267) in intron 3 was associated with increased risk of PC with an odds ratio of 1.57 (95%CI 1.03-2.38, p = 0.035) per allele. The three markers of the highest risk haplotype had an odds ratio of 1.98 (95%CI 1.12-3.49, p = 0.019) for risk of PC compared to the most common haplotype. There was no evidence of interaction between either of these associations by diabetes status.


CONCLUSIONS
These results suggest that variation in CAPN10 may be associated with increased risk of PC among smokers. Thus, studies of genes associated with diabetes risk in PC are warranted in a larger population.
Fong
Pui-yee
PY
Institute for Public Health Genetics, University of Washington, Box 357236, Seattle, WA 98195, USA.
Fesinmeyer
Megan D
MD
White
Emily
E
Farin
Federico M
FM
Srinouanprachanh
Sengkeo
S
Afsharinejad
Zahra
Z
Mandelson
Margaret T
MT
Brentnall
Teresa A
TA
Barnett
Matt J
MJ
Goodman
Gary E
GE
Austin
Melissa A
MA
D000368:Aged; D002154:Calpain / Q000235:genetics*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012907:Smoking / Q000009:adverse effects* / Q000235:genetics*
D002154:Calpain; C415197:calpain 10