[Mutation of the USP26 gene in spermatogenesis dysfunction].
The ubiquitin specific protease 26 (USP26) gene is located at Xq26.2 and present as a single exon on the X chromosome encoding for a protein of 913 amino acids. It belongs to a large family of deubiquitinating enzymes, and is exclusively expressed in the testis. There are conflicting reports on whether mutations in USP26 are associated with male infertility. This article updates the researches on the USP26 gene, its complicated relationship with male spermatogenesis dysfunction, the role of its mutation in male infertility, its geographical or ethnic distribution, and its evolution.
Wei
Li
L
PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China. weili1016@163.com
Shi
Yi-Chao
YC
Cui
Ying-Xia
YX
Huang
Yu-Feng
YF
D003546:Cysteine Endopeptidases / Q000235:genetics*; D006801:Humans; D007248:Infertility, Male / Q000235:genetics; D008297:Male; D013091:Spermatogenesis / Q000235:genetics*
C501866:USP26 protein, human; D003546:Cysteine Endopeptidases