title: Association between gefitinib and hemorrhagic cystitis and severely contracted bladder: a case report.
abstract: BACKGROUND
  Gefitinib remains an excellent treatment option for patients with a variety of cancers, including non small cell lung cancer (NSCLC). However, clinicians must be aware of the potential of gefitinib to cause an inflammatory reaction in the skin, lungs and bladder.
  
  
  METHODS
  We present a case on hemorrhagic cystitis and severely contracted bladder in a patient with NSCLC on gefitinib.
  
  
  CONCLUSIONS
  Further studies are needed to substantiate the association of gefitinib therapy with hemorrhagic cystitis and contracted bladder.
authors.affiliation: Department of Urology, Aichi Medical University School of Medicine, Nagakute, Aichi 480-1195, Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Arakawa
authors.forename: Kogenta
authors.initials: K
authors.lastname: Nakamura
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Yamada
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Rosser
authors.forename: Motoi
authors.initials: M
authors.lastname: Tobiume
authors.forename: Hiroko
authors.initials: H
authors.lastname: Saito
authors.forename: Takaaki
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Honda
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy; D003556:Cystitis / Q000139:chemically induced* / Q000175:diagnosis*; D000077156:Gefitinib; D006417:Hematuria / Q000139:chemically induced* / Q000175:diagnosis*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011799:Quinazolines / Q000009:adverse effects* / Q000627:therapeutic use; D001745:Urinary Bladder Diseases / Q000139:chemically induced* / Q000175:diagnosis*
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines; D000077156:Gefitinib