title: Evaluation of the memory CD4+ and CD8+ T cells homeostasis during chronic venous disease of lower limbs.
abstract: More and more is known about the role of venous wall abnormalities and valvular incompetence in the development of chronic venous disorders (CVD). Unfortunately detailed mechanisms of CVD pathophysiology are not well understood. Recent studies focus on involvement of the inflammatory process in the structural remodeling of venous valves and venous wall. The aim of this study is to investigate and to document the memory T cells homeostasis in CVD patients. In this study we present lymphocytic changes in blood from varicose veins in terms of total CD4+ and CD8+ T cells and their particular subsets of memory T cells: TN, TCM and TEM. Results suggest that immunological memory may be involved in the CVD development.
authors.affiliation: Department of Microbiological Diagnostics, Medical University of Bialystok, Poland.
authors.forename: Dominika
authors.initials: D
authors.lastname: Ojdana
authors.forename: Kamil
authors.initials: K
authors.lastname: Safiejko
authors.forename: Robert
authors.initials: R
authors.lastname: Milewski
authors.forename: Paweł
authors.initials: P
authors.lastname: Sacha
authors.forename: Piotr
authors.initials: P
authors.lastname: Wieczorek
authors.forename: Alina
authors.initials: A
authors.lastname: Lipska
authors.forename: Piotr
authors.initials: P
authors.lastname: Radziwon
authors.forename: Jacek
authors.initials: J
authors.lastname: Dadan
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Tryniszewska
mesh_terms: D000328:Adult; D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D002908:Chronic Disease; D005260:Female; D005434:Flow Cytometry; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D035002:Lower Extremity / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D014648:Varicose Veins / Q000276:immunology / Q000503:physiopathology; D014652:Vascular Diseases / Q000276:immunology* / Q000503:physiopathology*; D055815:Young Adult