title: Immunotoxicity activity of the major essential oil of Filipendula glaberrima against Aedes aegypti L.
abstract: The aerial parts of Filipendula glaberrima were extracted and the composition and immunotoxicity effects of major essential oils were studied. The analyses conducted by gas chromatography and mass spectroscopy (GC-MS) revealed the essential oils of F. glaberrima. The F. glaberrima essential oil (FGEO) yield was 0.046%, and GC/MS analysis revealed that its major constituents were β-farnesol (2.96%), l-α-terpineol (2.43%), benzenemethanol (2.87%), (Z)-3-hexen-1-ol (5.23%), and 2,6-bis(1,1-dimethylethyl)-4-methylphenol (1.91%). The essential oil had a significant toxic effect against early fourth stage larvae of Aedes aegypti L with an LC(50) value of 28.43 ppm and an LC(90) value of 76.21 ppm. The results could be useful in search for newer, safer, and more effective natural immunotoxicity agents against A. aegypti.
authors.affiliation: Department of Integrative Medicine, College of Medicine, Korea University, Seoul, South Korea.
authors.forename: Sung-Jae
authors.initials: SJ
authors.lastname: Lee
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Moon
mesh_terms: D000330:Aedes / Q000187:drug effects*; D000818:Animals; D019905:Benzyl Alcohol / Q000032:analysis; D002084:Butylated Hydroxytoluene / Q000032:analysis; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes / Q000032:analysis; D005204:Farnesol / Q000032:analysis; D031984:Filipendula / Q000737:chemistry*; D000441:Hexanols / Q000032:analysis; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D039821:Monoterpenes / Q000032:analysis; D009822:Oils, Volatile / Q000032:analysis / Q000494:pharmacology*; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D000441:Hexanols; D039821:Monoterpenes; D009822:Oils, Volatile; D010936:Plant Extracts; D002084:Butylated Hydroxytoluene; C016775:alpha-terpineol; C051918:3-hexen-1-ol; D005204:Farnesol; D019905:Benzyl Alcohol