title: Traffic-related air pollution and cardiovascular mortality in central Taiwan.
abstract: In this study, the relationship between cardiovascular mortality and traffic-related air pollutants (NO(2), CO, PM(10), and six volatile organic compounds (VOCs), propane, iso-butane, propylene, benzene, meta-, para-, and ortho-xylenes) was investigated. The concentrations of NO(2), PM(10) and CO from 1993 to 2006 were measured at a fixed-site air monitoring station, and VOC data from 2003 to 2006 were obtained from a photochemical assessment monitoring site in an urban area in central Taiwan. Outcome variables were data on mortality due to cardiovascular diseases (ICD-9-CM 410-411, 414, 430-437) from 1993 to 2006. Cardiovascular mortality averaged 1.5 cases, ranging between 0 and 9 cases per day. Daily air pollution levels ranged from 0.5 to 80.5ppb for NO(2) and from 0.1 to 3.8ppm for CO. From the subset of data from 2003 to 2006, daily average values ranged from 0.6 to 17.5ppb for propane, 0.3 to 6.7ppb for iso-butane, 0.3 to 6.7ppb for propylene, 0.2 to 3.8ppb for benzene, 0.3 to 26.0ppb for m,p-xylene, and 0.02 to 7.6ppb for o-xylene. Poisson generalized additive model was used to estimate the effects of elevated air pollutant levels on daily mortality, adjusting for meteorological conditions and temporal trends. Single-pollutant model showed that cardiovascular mortality was significantly associated with NO(2) lagged 2 days, and with propane, iso-butane, and benzene lagged 0 day. The relative risk for an interquartile range increase in air pollutant levels was 1.053 for NO(2), 1.064 for propane, 1.055 for iso-butane, and 1.055 for benzene. In conclusion, daily cardiovascular mortality showed association with data on acute exposure to traffic air pollutants in Taichung, which is an important factor to consider in studying cardiovascular mortality in urban environments.
authors.affiliation: Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan.
authors.forename: Dai-Hua
authors.initials: DH
authors.lastname: Tsai
authors.forename: Jia-Lin
authors.initials: JL
authors.lastname: Wang
authors.forename: Kai-Jen
authors.initials: KJ
authors.lastname: Chuang
authors.forename: Chang-Chuan
authors.initials: CC
authors.lastname: Chan
mesh_terms: D000393:Air Pollutants / Q000633:toxicity*; D000397:Air Pollution / Q000009:adverse effects*; D002245:Carbon Dioxide / Q000633:toxicity; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000378:metabolism / Q000401:mortality* / Q000473:pathology; D002947:Cities / Q000453:epidemiology; D004781:Environmental Exposure / Q000009:adverse effects*; D006801:Humans; D009589:Nitrogen Oxides / Q000633:toxicity; D052638:Particulate Matter / Q000633:toxicity; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D013997:Time Factors; D014504:Urban Health / Q000639:trends; D001335:Vehicle Emissions / Q000633:toxicity*; D055549:Volatile Organic Compounds / Q000633:toxicity
chemical_list: D000393:Air Pollutants; D009589:Nitrogen Oxides; D052638:Particulate Matter; D001335:Vehicle Emissions; D055549:Volatile Organic Compounds; D002245:Carbon Dioxide