Effects of chronic nicotine on food intake and anxiety-like behaviour in CB(1) knockout mice.
We have evaluated the effects of chronic nicotine administration and withdrawal in food intake and preference, metabolic parameters and anxiety-like behaviour in CB(1) knockout mice and wild-type littermates. Mutant mice showed lower levels of glucose, insulin and cholesterol after two weeks of high fat diet and reduced preference for saccharin solution when compared with wild-type mice. Nicotine reduced body weight and induced anxiogenic-like effects in wild-type, but not in CB(1) knockout mice. Our results suggest a modulatory role of the endocannabinoid system on the effects induced by nicotine on metabolic parameters and anxiety-like responses.
Bura
S Andreea
SA
Laboratori de Neurofarmacologia, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, PRBB Barcelona, Spain.
Burokas
Aurelijus
A
Martín-García
Elena
E
Maldonado
Rafael
R
D000818:Animals; D001007:Anxiety / Q000523:psychology*; D001522:Behavior, Animal / Q000187:drug effects*; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects; D005518:Food Preferences / Q000187:drug effects; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000187:drug effects; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics / Q000502:physiology*; D012439:Saccharin
D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D018722:Nicotinic Agonists; D043884:Receptor, Cannabinoid, CB1; D009538:Nicotine; D002784:Cholesterol; D012439:Saccharin