Identification of a common autoantigenic epitope of protein disulfide isomerase, golgin-160 and voltage-gated potassium channel in type 1 diabetes.
A common epitope of proteins golgin-160, voltage-gated potassium channel and disulfide isomerase was identified by screening with autoantibodies of a type 1 diabetic (T1D) patient a lambdaUni-Zap cDNA library from human diabetic islets. The significance of the identified autoantigens to the disease pathogenesis remains to be elucidated.
Fierabracci
Alessandra
A
Autoimmunity and Organ Regeneration Laboratory, Children's Hospital Bambino Gesù, Research Institute (IRCCS), Piazza S. Onofrio 4, 00165 Rome, Italy. fierabracci@opbg.net
Saura
Francesca
F
D001323:Autoantibodies; D001324:Autoantigens / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D000939:Epitopes; D015723:Gene Library; D000077614:Golgi Matrix Proteins; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology*; D024642:Potassium Channels, Voltage-Gated / Q000276:immunology*; D019704:Protein Disulfide-Isomerases / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens; D000939:Epitopes; C108388:GOLGA3 protein, human; D000077614:Golgi Matrix Proteins; D008565:Membrane Proteins; D024642:Potassium Channels, Voltage-Gated; D019704:Protein Disulfide-Isomerases