Cytotoxic germacranolide sesquiterpenes from the bark of Magnolia kobus.
A new (3) and three known germacrane-type sesquiterpenoids were isolated from the chloroform-soluble fraction of the methanolic extract of the bark of Magnolia kobus (Magnoliaceae) through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as costunolide (1), parthenolide (2), isobisparthenolidine (3), and bisparthenolidine (4) by spectroscopic analysis. Compounds 1-4 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.
Park
Hee Wook
HW
Department of Oriental Alternative Medicine, Nambu University, Gwangju 506-706, Korea.
Lee
Jae Hyeok
JH
Choi
Sang-Un
SU
Baek
Nam-In
NI
Kim
Sung-Hoon
SH
Yang
Jae Heon
JH
Kim
Dae Keun
DK
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D031566:Magnolia / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; D045788:Sesquiterpenes, Germacrane; C432449:germacranolide