A comparative study on the outcomes of in vitro fertilization between women with polycystic ovary syndrome and those with sonographic polycystic ovary-only in GnRH antagonist cycles.
OBJECTIVE
This study was performed to compare the outcomes of controlled ovarian stimulation (COH) and IVF between women with PCOS and those with sonographic PCO-only in GnRH antagonist cycles.


METHODS
This was a retrospective study of women with PCOS (n = 42) and those with sonographic PCO-only (n = 54) undergoing IVF. Responses to COH, adverse events such as severe ovarian hyperstimulation syndrome (OHSS), embryological and pregnancy outcomes were compared between the two groups using GnRH antagonist cycles and between GnRH agonist and antagonist protocols in the two groups, respectively.


RESULTS
There were no differences in the duration of stimulation, dose of gonadotropins used, E(2) level on hCG day, numbers of retrieved oocytes, and incidence of sever OHSS between PCOS and sonographic PCO-only groups, which was also observed both in GnRH agonist and antagonist subgroups. Pregnancy rates between PCOS and sonographic PCO-only groups in GnRH agonist (21.7 vs. 34.4%, P = 0.238) and antagonist (26.3 vs 22.7%, P = 0.537) subgroups did not differ. In regard to COH regimen, GnRH agonist long protocols showed higher responses than antagonist protocols both in PCOS group [number of retrieved oocytes (13.2 +/- 5.8 vs. 8.2 +/- 3.2, P < 0.001)] and sonographic PCO-only group [number of retrieved oocytes (13.7 +/- 5.2 vs. 9.2 +/- 6.7, P = 0.008); E(2) level on hCG day (3,005.1 +/- 1,317.1 vs. 1,525.9 +/- 738.6 pg/mL, P < 0.001)].


CONCLUSIONS
Women with PCOS and sonographic PCO-only may have similar outcome during COH cycle for IVF.
Kim
Yong Jin
YJ
Department of Obstetrics and Gynecology, College of Medicine, Seoul National University, 28 Yonkeun-dong, Chongno-gu, Seoul 110-744, South Korea.
Ku
Seung-Yup
SY
Jee
Byung Chul
BC
Suh
Chang Suk
CS
Kim
Seok Hyun
SH
Choi
Young Min
YM
Kim
Jung Gu
JG
Moon
Shin Yong
SY
D000328:Adult; D015232:Dinoprostone / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists / Q000037:antagonists & inhibitors*; D006062:Gonadotropins / Q000008:administration & dosage*; D006801:Humans; D054315:Oocyte Retrieval; D016471:Ovarian Hyperstimulation Syndrome / Q000139:chemically induced; D010053:Ovary / Q000000981:diagnostic imaging; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D014463:Ultrasonography
D006062:Gonadotropins; D007987:Gonadotropin-Releasing Hormone; D015232:Dinoprostone