Demineralized bone matrix for fracture healing: fact or fiction?
Demineralized bone matrix (DBM) has been touted as an excellent grafting material; however, there are no Level I studies that use DBM alone in humans to back up this claim. DBM functions best in a healthy tissue bed but should be expected to have little impact in an anoxic or avascular tissue bed, a situation often encountered in traumatic orthopaedic pathologies. Moreover, there is some evidence of differential potencies of DBM preparations based on donor variability and the manufacturing process. DBM efficacy may also be related to its formulation and the various carriers used. The fact that DBM is an allogeneic material opens up the potential for disease transmission. In addition, DBM activity may be altered by the hormonal status or nicotine use of a patient. In summary, although DBM has proven effective for bone induction in lower form animals, the translation to human clinical use for fracture healing, and the burden of proof, remains.
Kinney
Ramsey C
RC
Department of Orthopaedics, Atlanta Medical Center, Atlanta, GA, USA.
Ziran
Bruce H
BH
Hirshorn
Kurt
K
Schlatterer
Daniel
D
Ganey
Timothy
T
D018775:Bone Demineralization Technique / Q000379:methods*; D001857:Bone Matrix / Q000637:transplantation*; D001842:Bone and Bones / Q000503:physiopathology* / Q000601:surgery*; D017102:Fracture Healing / Q000502:physiology*; D050723:Fractures, Bone / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans