8,15-epoxylabdane and norlabdane diterpenoids from Eragrostis viscosa.
Four labdanes with a 8alpha,15-epoxy ring (8alpha,15-epoxylabdan-16beta-oic acid; 8alpha,15-epoxy-16-norlabdan-13-one; 8alpha,15-epoxy-16-norlabdane; and 16-acetoxy-8alpha,15-epoxylabdane) and the known compound ambreinolide were isolated from the hexane extract of the aerial parts of the grass Eragrostis viscosa. The structures of all compounds were established based on spectroscopic data and the X-ray analysis of 8alpha,15-epoxy-16-norlabdan-13-one. The hexane extract presented moderate activity against the snail Biomphalaria glabrata. 8alpha,15-Epoxylabdan-16beta-oic acid showed no mutagenic activity for doses up to 1000 microg/plate and no significant clastogenic activity for doses up to 100 microg/ml.
Sebastião
N'Soki N
NN
Chemistry Department, Agostinho Neto University, Luanda, Angola.
Cordeiro
Inês J S
IJ
dos Santos
Aldenir F
AF
Gaspar
Jorge F
JF
Martins
Célia
C
Rueff
José
J
Diakanamwa
Carlos
C
Sant'Ana
Antônio E G
AE
de Mendonça
Dina I M D
DI
D000818:Animals; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000032:analysis*; D031750:Eragrostis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D012908:Snails
D004224:Diterpenes