Lipid kinases: charging PtdIns(4,5)P2 synthesis.
Phosphatidylinositol (4,5) bisphosphate is a lipid second messenger that controls diverse cellular processes. Phosphatidylinositolphosphate-5-kinases synthesise this lipid at the plasma membrane, although it is not clear how the localisation of these kinases is controlled. A recent study suggests that the intrinsic surface charge of the plasma membrane may be an important factor.
Divecha
Nullin
N
Inositide Laboratory, The Paterson Institute for Cancer Research, Manchester University, Manchester M20 4BX, UK. ndivecha@picr.man.ac.uk
D002462:Cell Membrane / Q000378:metabolism*; D010587:Phagocytosis / Q000502:physiology*; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates / Q000096:biosynthesis*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D015290:Second Messenger Systems / Q000502:physiology*; D055672:Static Electricity
D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D017853:Phosphotransferases (Alcohol Group Acceptor); C020077:1-phosphatidylinositol-4-phosphate 5-kinase