title: Association analysis between polymorphism rs2373115 of gene GRB-associated binding protein 2 and Mongolian Alzheimer patients.
abstract: GRB-associated binding protein 2 (GAB2) may function as a risk factor of Alzheimer disease (AD) by affecting hyperphosphorylation of tau, causing neurofibrillary tangles. There had been genomewide analysis discovering polymorphism rs2373115 correlated with AD and in this study we performed an association analysis on this polymorphism in 107:100 Mongolian Alzheimer patients and controls in order to discover whether this correlation can be replicated in Chinese minority group. The results showed negative results, indicating GAB2 rs2373115 polymorphism was not a remarkable factor in developing Alzheimer disease among Mongolian.
authors.affiliation: Graduate School, Peking Union Medical College, Beijing 100730, China.
authors.forename: Sirui
authors.initials: S
authors.lastname: Zhou
authors.lastname: Huriletemuer
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Binbin
authors.initials: B
authors.lastname: Wang
authors.forename: Shigang
authors.initials: S
authors.lastname: Zhao
authors.forename: De Sheng
authors.initials: de S
authors.lastname: Wang
authors.forename: Chunyu
authors.initials: C
authors.lastname: Zhang
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D044466:Asian People; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008986:Mongolia; D011110:Polymorphism, Genetic
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C490895:GAB2 protein, human