title: HLA-DR association in papillary thyroid carcinoma.
abstract: OBJECTIVE
  Papillary thyroid carcinoma (PTC) is the most frequent types of thyroid malignancies. Several genes may be involved in susceptibility of thyroid cancer including Human Leukocyte Antigens (HLA). The association of thyroid carcinoma with HLA alleles has been previously studied in other populations and certain HLA alleles were shown to be either predisposing or protective. The aim of this study was to determine the association between HLA-DR and papillary thyroid carcinoma in an Iranian population.
  
  
  METHODS
  HLA-DR antigen frequencies were determined in patients with papillary thyroid carcinoma (N=70) and non-related healthy controls (N=180) using PCR -SSP.
  
  
  RESULTS
  We found that HLA-DRB1*04 frequency was significantly higher in our patients compared to the controls [P=0.02, OR; 1.9, 95% CI (1.04-3.57)].
  
  
  CONCLUSIONS
  Our results revealed HLA-DRB1*04 as predisposing factor in papillary thyroid carcinoma in Iranian population. This confirms the previous findings for associations between HLA-DRB1 and differentiated carcinomas in other populations.
authors.affiliation: Endocrinology and metabolism research centre, Tehran university of medical sciences, Tehran, Iran. mahsa_amoli@hotmail.com
authors.forename: Mahsa M
authors.initials: MM
authors.lastname: Amoli
authors.forename: Nasrin
authors.initials: N
authors.lastname: Yazdani
authors.forename: Parvin
authors.initials: P
authors.lastname: Amiri
authors.forename: Forogh
authors.initials: F
authors.lastname: Sayahzadeh
authors.forename: Vahid
authors.initials: V
authors.lastname: Haghpanah
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Tavangar
authors.forename: Ali
authors.initials: A
authors.lastname: Amirzargar
authors.forename: Hamidollah
authors.initials: H
authors.lastname: Ghaffari
authors.forename: Behrooz
authors.initials: B
authors.lastname: Nikbin
authors.forename: Bagher
authors.initials: B
authors.lastname: Larijani
authors.forename: Leila V
authors.initials: LV
authors.lastname: Mostaan
authors.forename: Javad Tavakkoly
authors.initials: JT
authors.lastname: Bazzaz
mesh_terms: D000328:Adult; D002291:Carcinoma, Papillary / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D015236:HLA-C Antigens; D006684:HLA-DR Antigens