A novel strategy to selectively detect Fe(III) in aqueous media driven by hydrolysis of a rhodamine 6G Schiff base.
A rhodamine-based probe (FS1) was synthesized and its fluorescence properties and application to an iron-overloaded cell line demonstrated. FS1 underwent fluorogenic changes by the Fe(3+)-catalyzed reaction, even in the presence of other metal cations in vitro. Chemodosimeter FS1 demonstrated selective and sensitive detection of intracellular Fe(3+) in hepatocytes.
Lee
Min Hee
MH
Department of Chemistry, Korea University, Seoul 136-701, Korea.
Giap
Thang Van
TV
Kim
Sang Hoon
SH
Lee
Young Hoon
YH
Kang
Chulhun
C
Kim
Jong Seung
JS
D005456:Fluorescent Dyes / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007501:Iron / Q000378:metabolism*; D012235:Rhodamines / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014867:Water / Q000737:chemistry*
D005456:Fluorescent Dyes; D012235:Rhodamines; D012545:Schiff Bases; C026188:rhodamine 6G; D014867:Water; D007501:Iron