title: [Seizure and non-cardiogenic pulmonary edema after intoxication].
abstract: We report a case of severe intoxication with extended-release verapamil. In addition to cardiovascular toxicities with hypotension, atrioventricular block and bradycardia, the patient suffered from grand-mal seizure and pulmonary edema 13 and 48 hours respectively, after ingestion of 4.8 g of extended-release verapamil. Adverse reactions after intoxications with extended-release tablets appear delayed with prolonged manifestation of symptoms. Early and repetitive administration of activated charcoal and antegrade whole bowel lavage are crucial, even in primary asymptomatic patients.
authors.affiliation: Medizinische Klinik, Universitätsspital Basel, Basel, Schweiz.
authors.forename: M
authors.initials: M
authors.lastname: Sawatzki
authors.forename: O
authors.initials: O
authors.lastname: Kummer
authors.forename: S
authors.initials: S
authors.lastname: Krähenbühl
authors.forename: M
authors.initials: M
authors.lastname: Siegemund
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000150:complications; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000175:diagnosis*; D012640:Seizures / Q000139:chemically induced* / Q000175:diagnosis*; D014700:Verapamil / Q000633:toxicity*
chemical_list: D014700:Verapamil