Synthesis and applications of diethylstilbestrol-based molecularly imprinted polymer-coated hollow fiber tube.
A novel molecularly imprinted polymer-coated polypropylene hollow fiber tube (MIP-HFT) was photoinitiated for the copolymerization of diethylstilbestrol (DES) as a template molecule, alpha-methacrylic acid as a functional monomer, and ethylene glycol dimethacrylate as a crosslinking agent. The characteristics and applications of the MIP-HFT were investigated. In order to compare its characteristics with those of a non-imprinted polymer-immersed hollow fiber tube, the selectivity of the MIP-HFT was investigated using dienestrol and hexestrol as the structural analogues of a DES template, and phenol and methylbenzene were taken as reference compounds. The MIP-HFT was employed in the HPLC analysis of spiked milk samples. The detection limits of the method were found to be in the range 2.5-3.3microgL(-1) for DES, dienestrol and hexestrol and the RSD% were in the range 6.4-8.9. The limits of quantitation were found to be in the range 8.7-9.4microgL(-1) in milk for DES, dienestrol and hexestrol, and their average recoveries were 83.7-90.6% in the spiked milk samples. The experimental results revealed that the MIP-HFT provides a good carrier for the selective adsorption of DES and its chemical structure analogs, and can be used for the preconcentration of these compounds in complicated samples.
Liu
Meihua
M
Ministry of Education Key Laboratory of Analysis and Detection Technology for Food Safety (Fuzhou University), Department of Chemistry, Fuzhou University, Fuzhou 350002, China.
Li
Meijin
M
Qiu
Bin
B
Chen
Xi
X
Chen
Guonan
G
D002851:Chromatography, High Pressure Liquid; D020099:Coated Materials, Biocompatible / Q000138:chemical synthesis* / Q000737:chemistry; D004054:Diethylstilbestrol / Q000737:chemistry*; D008567:Membranes, Artificial; D054802:Molecular Imprinting; D015394:Molecular Structure; D010316:Particle Size; D011126:Polypropylenes / Q000138:chemical synthesis* / Q000737:chemistry; D013499:Surface Properties
D020099:Coated Materials, Biocompatible; D008567:Membranes, Artificial; D011126:Polypropylenes; D004054:Diethylstilbestrol