A hepatitis B virus inhibitory neolignan from Herpetospermum caudigerum.
A new dihydrobenzofuran neolignan, herpepropenal, was isolated from the seeds of Herpetospermum caudigerum. Its chemical structure was established based on spectroscopic analysis. In this work, the inhibitory effects of herpepropenal on hepatitis B virus DNA and on the replication and expression of hepatitis B surface antigen and hepatitis B e antigen were also evaluated. The new compound exhibited inhibitory effects against hepatitis B virus.
Yang
Fan
F
Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P. R. China.
Zhang
Hong-Jun
HJ
Zhang
Yuan-Yuan
YY
Chen
Wan-Sheng
WS
Yuan
Hai-Long
HL
Lin
Hou-Wen
HW
D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D019662:Cucurbitaceae / Q000737:chemistry*; D004279:DNA, Viral / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006514:Hepatitis B Surface Antigens / Q000378:metabolism; D006568:Herpesvirus 1, Cercopithecine / Q000187:drug effects*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D012639:Seeds / Q000737:chemistry*; D014779:Virus Replication / Q000187:drug effects
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D017705:Lignans; C549744:herpepropenal