title: Multifocal conduction blocks in sarcoid peripheral neuropathy.
abstract: Peripheral neuropathy is a rare manifestation of sarcoidosis, and previous studies have shown axonal degeneration as the main pathology. We herein report three patients with sarcoidosis who presented with multiple mononeuropathy as the initial manifestation. Nerve conduction studies showed prominent multifocal conduction blocks in the intermediate nerve trunk. In all three patients, corticosteroid treatment resulted in a dramatic clinical improvement associated with rapid resolution of conduction blocks. The sequential electrodiagnostic findings suggest that demyelinative or ischemic-functional conduction block is responsible for their neuropathy. To date, only three cases of acute conduction block neuropathy associated with sarcoidosis have been reported, but it may occur more frequently than expected.
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University.
authors.forename: Setsu
authors.initials: S
authors.lastname: Sawai
authors.forename: Sonoko
authors.initials: S
authors.lastname: Misawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Kanai
authors.forename: Sagiri
authors.initials: S
authors.lastname: Isose
authors.forename: Kazumoto
authors.initials: K
authors.lastname: Shibuya
authors.forename: Yukari
authors.initials: Y
authors.lastname: Sekiguchi
authors.forename: Saiko
authors.initials: S
authors.lastname: Nasu
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Noto
authors.forename: Yumi
authors.initials: Y
authors.lastname: Fujimaki
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Koga
authors.forename: Ryohei
authors.initials: R
authors.lastname: Ohtani
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwabara
mesh_terms: D000368:Aged; D004568:Electrodiagnosis; D005260:Female; D006801:Humans; D008875:Middle Aged; D009410:Nerve Degeneration / Q000175:diagnosis / Q000503:physiopathology; D009431:Neural Conduction / Q000502:physiology*; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D012507:Sarcoidosis / Q000150:complications*