title: Hairy-related transcription factor 2 is not potentially related to congenital heart disease in Chinese patients.
abstract: Congenital heart disease (CHD) is the malformation of the heart during embryonic development, contributing to the inadequate function of the heart. A recently suggested gene hairy-related transcription factor 2 (HEY2), is an important determinant of mammalian heart development and functions thereby. We had preformed a direct sequencing within 768 Chinese CHD patients in the HEY2 gene. However, we did not reveal any diagnostic alterations in the coding regions by direct sequencing in HEY2, nevertheless this work expands our knowledge of the causes of CHD in the other way.
authors.affiliation: Graduate school, Peking Union Medical College, Beijing, China.
authors.forename: Binbin
authors.initials: B
authors.lastname: Wang
authors.forename: Shiyi
authors.initials: S
authors.lastname: Zhou
authors.forename: Qiuhong
authors.initials: Q
authors.lastname: Chen
authors.forename: XiaoDong
authors.initials: X
authors.lastname: Xie
authors.forename: Guoying
authors.initials: G
authors.lastname: Huang
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Sirui
authors.initials: S
authors.lastname: Zhoua
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
mesh_terms: D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D002681:China; D006330:Heart Defects, Congenital / Q000235:genetics*; D006331:Heart Diseases / Q000151:congenital* / Q000235:genetics*; D006801:Humans; D012097:Repressor Proteins / Q000235:genetics*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D012097:Repressor Proteins; C405693:HEY2 protein, human