title: Therapeutic effects on murine oral candidiasis by oral administration of cassia (Cinnamomum cassia) preparation.
abstract: We examined the effects of spices and herbs on Candida albicans growth using in vitro assay and therapeutic activity of some selected herbal preparations against murine oral candidiasis. All tested samples: lemongrass (Cymbopogon citratus), lemon balm (Melissa officinalis), thyme (Thymus vulgaris), rosemary (Rosmarinus officinalis), roselle (Hibiscus sabdariffa), green tea (Camellia sinensis), and cassia (Cinnamomum cassia) inhibited Candida mycelial growth in vitro. The results of this assay showed that the anti-Candida activity of lemongrass, green tea, and cassia is stronger than that of the other tested herbs. Oral administration of lemongrass or green tea did not result in significant improvement in the murine oral candidiasis, while the administration of cassia improved the symptoms and reduced the number of viable Candida cells in the oral cavity. The results of in vitro Candida growth assay including GC/MS analysis suggested that cinnamaldehyde in the cassia preparation was the principal component responsible for the inhibitory activity of Candida mycelial growth. These findings suggest that oral intake of a cassia preparation is a clinical candidate for a prophylactic or therapeutic tool against oral Candida infection.
authors.affiliation: Research and Product Development Division, S & B Foods Inc., Tokyo, Japan.
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Taguchi
authors.forename: Toshio
authors.initials: T
authors.lastname: Takizawa
authors.forename: Hiroko
authors.initials: H
authors.lastname: Ishibashi
authors.forename: Takehito
authors.initials: T
authors.lastname: Sagawa
authors.forename: Ryo
authors.initials: R
authors.lastname: Arai
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Inoue
authors.forename: Hideyo
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Abe
mesh_terms: D000171:Acrolein / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D002176:Candida albicans / Q000187:drug effects; D002180:Candidiasis, Oral / Q000188:drug therapy*; D032904:Cinnamomum aromaticum / Q000737:chemistry*; D031743:Cymbopogon; D004195:Disease Models, Animal; D025141:Drug Resistance, Fungal; D005260:Female; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D028321:Plant Preparations / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D028321:Plant Preparations; D000171:Acrolein; C012843:cinnamaldehyde