title: Flavonoids, anti-inflammatory activity and cytotoxicity of Macfadyena unguis-cati L.
abstract: Ethyl acetate and ethanol extracts of unflowering aerial part of Macfadyena unguis-cati L. (Fam. Bignoniaceae) were found to be rich in phenolic compounds. From ethyl acetate extract, six flavonoids were identified, 8, methoxy, acacetin, 7-O glucoside; 6, methoxy apigenin 7-O glucoside; 4'-O methyl scutellarin, 6-O apiosyl galactoside; acacetin, 7-O glucosyl, 8-C rhamnosyl, 3-O-alpha arabinofuranoside; 4'-methyl, 6- methoxy kaempferol, 7-O, 8-C diglucoside and vicenin II were isolated, while 6, methoxy, acacetin 7-O glucoside; and quercitrin were isolated from ethanol extract. These compounds were characterized and identified by their physicochemical and spectral data. The crude ethanol extract exhibited significant anti-inflammatory activity (80.47%) and moderate cytotoxic activity against lung cell line.
authors.affiliation: Pharmacognosy Department., Faculty of Pharmacy, Cairo University, Egypt.
authors.forename: E A
authors.initials: EA
authors.lastname: Aboutabl
authors.forename: F A
authors.initials: FA
authors.lastname: Hashem
authors.forename: A A
authors.initials: AA
authors.lastname: Sleem
authors.forename: A A
authors.initials: AA
authors.lastname: Maamoon