T cells use rafts for survival.
T cell homeostasis must be tightly controlled. In this issue of Immunity, Cho et al. (2010) describe results that begin to define the roles of the T cell receptor, self-peptide-MHC ligands, cytokines, and membrane rafts in this dynamic process.
Stone
Jennifer D
JD
Department of Biochemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Kranz
David M
DM
D000818:Animals; D015703:Antigens, CD / Q000378:metabolism; D001324:Autoantigens / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D002470:Cell Survival / Q000276:immunology; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006649:Histocompatibility Antigens / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D008213:Lymphocyte Activation; D021962:Membrane Microdomains / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
D015703:Antigens, CD; D001324:Autoantigens; D016207:Cytokines; D006649:Histocompatibility Antigens; D010446:Peptide Fragments; D011948:Receptors, Antigen, T-Cell