title: Bioresorbable scaffolds for anterior cruciate ligament reconstruction: do we need an off-the-shelf ACL substitute?
abstract: Currently available anterior cruciate ligament (ACL) graft sources, autograft and allograft, present potential problems that a natural biomaterial ACL graft might be able to solve. Earlier efforts in the development of synthetic ACL grafts were less than optimal, and those devices have largely been abandoned. We can learn from these past failures, and potentially develop a bioresorbable scaffold for ACL reconstruction, which will provide immediate stability, promote and direct tissue in growth, and degrade at an appropriate rate, without harmful wear debris. We have developed a modified silk scaffold, which is currently being evaluated in humans in a pilot study.
authors.affiliation: Department of Orthopedic Surgery, New England Baptist Hospital, Tufts University School of Medicine, Boston Boston Sports and Shoulder Center, Chestnut Hill, MA, USA. jrichmon@nebh.org
authors.forename: John C
authors.initials: JC
authors.lastname: Richmond
authors.forename: Paul P
authors.initials: PP
authors.lastname: Weitzel
mesh_terms: D000818:Animals; D016118:Anterior Cruciate Ligament / Q000601:surgery*; D001182:Arthroscopy; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001696:Biomechanical Phenomena; D005260:Female; D006041:Goats; D006801:Humans; D007593:Joint Instability / Q000601:surgery; D007718:Knee Injuries / Q000601:surgery*; D010865:Pilot Projects; D016059:Range of Motion, Articular; D019651:Plastic Surgery Procedures / Q000379:methods*; D047011:Silk / Q000627:therapeutic use*; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D047011:Silk