title: Total synthesis of adicardin.
abstract: The first synthesis of adicardin, a compound with anti-chronic renal failure activity isolated from Hydrangea macrophylla, has been described. The structures of the target compound and intermediates have been validated by MS, NMR, and identical with the natural product.
authors.affiliation: Department of New Drug Research and Development, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Biosynthesis of Natural Products, Ministry of Health of PRC), Beijing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Wu
authors.forename: Yuan-Feng
authors.initials: YF
authors.lastname: Tong
authors.forename: Ling-Hua
authors.initials: LH
authors.lastname: Hao
authors.forename: Qing-Yun
authors.initials: QY
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Qi
authors.forename: Song
authors.initials: S
authors.lastname: Wu
mesh_terms: D005960:Glucosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D031966:Hydrangea / Q000737:chemistry*; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D015394:Molecular Structure; D013237:Stereoisomerism; D014468:Umbelliferones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D005960:Glucosides; D014468:Umbelliferones; C547626:adicardin