title: Exploring feature-based approaches in PET images for predicting cancer treatment outcomes.
abstract: Accumulating evidence suggests that characteristics of pre-treatment FDG-PET could be used as prognostic factors to predict outcomes in different cancer sites. Current risk analyses are limited to visual assessment or direct uptake value measurements. We are investigating intensity-volume histogram metrics and shape and texture features extracted from PET images to predict patient's response to treatment. These approaches were demonstrated using datasets from cervix and head and neck cancers, where AUC of 0.76 and 1.0 were achieved, respectively. The preliminary results suggest that the proposed approaches could potentially provide better tools and discriminant power for utilizing functional imaging in clinical prognosis.
authors.affiliation: Department of Radiation Oncology, Washington University School of Medicine St. Louis, MO, USA.
authors.forename: I
authors.initials: I
authors.lastname: El Naqa
authors.forename: P
authors.initials: P
authors.lastname: Grigsby
authors.forename: A
authors.initials: A
authors.lastname: Apte
authors.forename: E
authors.initials: E
authors.lastname: Kidd
authors.forename: E
authors.initials: E
authors.lastname: Donnelly
authors.forename: D
authors.initials: D
authors.lastname: Khullar
authors.forename: S
authors.initials: S
authors.lastname: Chaudhari
authors.forename: D
authors.initials: D
authors.lastname: Yang
authors.forename: M
authors.initials: M
authors.lastname: Schmitt
authors.forename: Richard
authors.initials: R
authors.lastname: Laforest
authors.forename: W
authors.initials: W
authors.lastname: Thorstad
authors.forename: J O
authors.initials: JO
authors.lastname: Deasy