title: PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel.
abstract: This study presents PKSolver, a freely available menu-driven add-in program for Microsoft Excel written in Visual Basic for Applications (VBA), for solving basic problems in pharmacokinetic (PK) and pharmacodynamic (PD) data analysis. The program provides a range of modules for PK and PD analysis including noncompartmental analysis (NCA), compartmental analysis (CA), and pharmacodynamic modeling. Two special built-in modules, multiple absorption sites (MAS) and enterohepatic circulation (EHC), were developed for fitting the double-peak concentration-time profile based on the classical one-compartment model. In addition, twenty frequently used pharmacokinetic functions were encoded as a macro and can be directly accessed in an Excel spreadsheet. To evaluate the program, a detailed comparison of modeling PK data using PKSolver and professional PK/PD software package WinNonlin and Scientist was performed. The results showed that the parameters estimated with PKSolver were satisfactory. In conclusion, the PKSolver simplified the PK and PD data analysis process and its output could be generated in Microsoft Word in the form of an integrated report. The program provides pharmacokinetic researchers with a fast and easy-to-use tool for routine and basic PK and PD data analysis with a more user-friendly interface.
authors.affiliation: Department of Pharmaceutics, China Pharmaceutical University, No.24, Tongjiaxiang, 210009, Nanjing, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Meirong
authors.initials: M
authors.lastname: Huo
authors.forename: Jianping
authors.initials: J
authors.lastname: Zhou
authors.forename: Shaofei
authors.initials: S
authors.lastname: Xie
mesh_terms: D000465:Algorithms; D019540:Area Under Curve; D003628:Database Management Systems / Q000295:instrumentation*; D004764:Enterohepatic Circulation / Q000187:drug effects*; D006801:Humans; D015233:Models, Statistical; D008962:Models, Theoretical; D017711:Nonlinear Dynamics; D010599:Pharmacokinetics; D010600:Pharmacology; D025341:Principal Component Analysis; D011340:Problem Solving; D012984:Software; D013223:Statistics as Topic