Brain glucose overexposure and lack of acute metabolic flexibility in obesity and type 2 diabetes: a PET-[18F]FDG study in Zucker and ZDF rats.
Brain glucose exposure may complicate diabetes and obesity. We used positron emission tomography with (18)F-fluorodeoxyglucose in Zucker obese, diabetic, and control rats to determine the contributions of blood glucose mass action versus local mechanisms in regulating central glucose disposal in fasted and acutely glucose-stimulated states, and their adaptations in obesity and diabetes. Our study data indicate that brain glucose uptake is dependent on both local and mass action components, and is stimulated by acute glucose intake in healthy rats. In diseased animals, the organ was chronically overexposed to glucose, due to high fasting glucose uptake, almost abolishing the physiologic response to glucose loading.
Liistro
Tiziana
T
Institute of Clinical Physiology, National Research Council (CNR), Pisa, Italy.
Guiducci
Letizia
L
Burchielli
Silvia
S
Panetta
Daniele
D
Belcari
Nicola
N
Pardini
Silvia
S
Del Guerra
Alberto
A
Salvadori
Piero A
PA
Iozzo
Patricia
P
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D005215:Fasting; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D008297:Male; D009765:Obesity / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D049268:Positron-Emission Tomography; D051381:Rats; D011924:Rats, Zucker
D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18