Effects of botulinum toxin-a therapy for palmar hyperhidrosis in plantar sweat production.
BACKGROUND
Patients with focal hyperhidrosis in multiple areas often report improvement of plantar hyperhidrosis after botulinum toxin A (BTX-A) therapy for palmar hyperhidrosis.


OBJECTIVE
To assess sweat production from the soles in patients receiving BTX-A treatment for their palmar hyperhidrosis.


METHODS
Thirty-six patients with both palmar and plantar hyperhidrosis received 100 U of BTX-A per palm. Sweat production of palms and soles was assessed using a starch iodine test and gravimetry at baseline and 1, 3, and 8 months after treatment. Patients were subjectively assessed using a percentile scale.


RESULTS
All patients had significant improvement in their palmar hyperhidrosis that lasted for 6.2 +/- 1.8 months. Gravimetry revealed marginal improvement of plantar hyperhidrosis in 12 patients (from 39.7 +/- 21.3 to 31.5 +/- 18.0 mg/min; p=.01) and statistically significant worsening in 24 patients (from 71.6 +/- 70.60 to 109.94 +/- 82.93 mg/min, p<.001).


CONCLUSIONS
Treatment of palmar hyperhidrosis with BTX-A increased plantar sweating in many patients affected by both palmar and plantar hyperhidrosis in the population under study. Regardless, patients reported satisfaction with the results and were willing to repeat treatment.
Gregoriou
Stamatis
S
Hyperhidrosis Clinic, A Sygros Hospital, Athens, Greece.
Rigopoulos
Dimitris
D
Makris
Michael
M
Liakou
Anastasia
A
Agiosofitou
Efi
E
Stefanaki
Christina
C
Kontochristopoulos
George
G
D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D005528:Foot; D006225:Hand; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy*; D009498:Neurotoxins / Q000627:therapeutic use; D017060:Patient Satisfaction; D013542:Sweat / Q000378:metabolism; D016896:Treatment Outcome
D009498:Neurotoxins; D019274:Botulinum Toxins, Type A