Molecular therapeutic approaches to melanoma.
Metastatic melanoma is a highly lethal cancer that has historically been refractory to all tested pharmacological agents. An understanding of the mechanisms responsible for its oncogenesis is critical for developing successful therapies. An enormous amount of data generated over the last few decades have revealed important biological insights into melanoma initiation, progression and maintenance, which bring new directions and approaches to treatment of this devastating skin cancer.
Ji
Zhenyu
Z
Wellman Center for Photomedicine/Dept of Dermatology, 55 Fruit Street, Boston, MA 02114, USA.
Flaherty
Keith T
KT
Tsao
Hensin
H
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008545:Melanoma / Q000188:drug therapy* / Q000378:metabolism; D015398:Signal Transduction
D000970:Antineoplastic Agents