Nephrotic syndrome from the genetic point of view.
Nephrotic syndrome, an entity described at the beginning of the 20th century, has still an unclear pathophysiology, genetic and immunologic factors being incriminated. Here we report three cases of nephrotic syndrome with genetic involvement. The article presented tremendous progress that have been made over the past few years in enhancing our understanding of the slit-diaphragm and podocyte biology and genetics involvement in nephrotic syndrome.
Cucer
Florentina
F
IVth Pediatric Clinic, School of Medicine,"Gr.T. Popa" University of Medicine and Pharmacy, Iaşi.
Rusu
Cristina
C
Muller
R
R
Munteanu
Mihaela
M
Mihăilă
Doina
D
Miron
Ingrith
I
Brumariu
O
O
D002675:Child, Preschool; D003241:Consanguinity; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D007438:Introns; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D017384:Sequence Deletion / Q000235:genetics
D008565:Membrane Proteins; C113267:nephrin