title: A totally implanted intra-arterial chemotherapy system for advanced maxillary sinus carcinoma.
abstract: CONCLUSIONS
  Both reservoir systems for intra-arterial cisplatin and intravenous sodium thiosulfate infusions are low- invasive, safe and effective procedures for treatment of advanced maxillary sinus carcinoma.
  
  
  OBJECTIVE
  To use our reservoir system for intra-arterial high-dose cisplatin infusion therapy in patients with advanced maxillary sinus carcinoma.
  
  
  METHODS
  Eight patients with advanced maxillary sinus carcinomas underwent treatment utilizing intra-arterial cisplatin (CDDP) infusion and radiation therapy followed by planned surgical resection. For intra-arterial infusion of high-dose cisplatin, both intra-arterial and intravenous reservoir systems were used.
  
  
  RESULTS
  CDDP was infused 4-6 times (mean 5.1) and the total dose of CDDP was between 690 and 910 mg (mean 771 mg). The response rate was 100 with 50% CR and 50% PR and all patients underwent medial maxillectomy. Only 1 T(4) patient had local recurrence and 1 other patient had bilateral neck metastasis.
authors.affiliation: Department of Otolaryngology, Kochi Medical School, Nankoku, Kochi, Japan. hnakatan@tcc.pref.tochigi.lg.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Nakatani
authors.forename: Kahori
authors.initials: K
authors.lastname: Hirose
authors.forename: Noboru
authors.initials: N
authors.lastname: Matsumoto
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Yamakawa
authors.forename: Akinobu
authors.initials: A
authors.lastname: Kakigi
authors.forename: Taizo
authors.initials: T
authors.lastname: Takeda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ito
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Yamanishi
authors.forename: Akihito
authors.initials: A
authors.lastname: Nishioka
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Nakahira
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000188:drug therapy* / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000188:drug therapy* / Q000601:surgery; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D002945:Cisplatin