Drug release from coronary eluting stents: A multidomain approach.
In this paper, starting from a consistent mathematical model, a novel computational approach is proposed for assessing some biomechanical effects on drug release from coronary drug-eluting stents (DESs), related to tissue properties, local hemodynamics and stent design. A multiscale and multidomain advection-diffusion model is formulated for describing drug dynamics in the polymeric substrate covering the stent, into the arterial wall, and in the vessel lumen. The model accounts for tissue microstructure (anisotropic drug diffusion, porosity, drug retention induced by resident proteins), macrostructure (plaque between stent and tissue), and local hemodynamics. In the case of hydrophobic taxus-based compounds, several numerical analyses have been carried out on simplified geometries by using finite element simulations, performing significant comparisons with other recent studies and highlighting general conclusions for assessing effectiveness of some modelling features as well as useful hints for optimizing drug delivery design and technology.
Vairo
Giuseppe
G
Dipartimento di Ingegneria Civile and Lagrange Laboratory, Università di Roma Tor Vergata, via del Politecnico 1, 00133 Roma, Italy. vairo@ing.uniroma2.it
Cioffi
Margherita
M
Cottone
Riccardo
R
Dubini
Gabriele
G
Migliavacca
Francesco
F
D000925:Anticoagulants / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003198:Computer Simulation; D023903:Coronary Restenosis / Q000503:physiopathology* / Q000517:prevention & control; D003331:Coronary Vessels / Q000503:physiopathology* / Q000601:surgery; D004058:Diffusion; D054855:Drug-Eluting Stents; D019544:Equipment Failure Analysis; D006083:Graft Occlusion, Vascular / Q000503:physiopathology* / Q000517:prevention & control; D006801:Humans; D008955:Models, Cardiovascular; D011474:Prosthesis Design
D000925:Anticoagulants