title: Chiral spiroaminoborate ester as a highly enantioselective and efficient catalyst for the borane reduction of furyl, thiophene, chroman and thiochroman containing ketones.
abstract: Prochiral heteroaryl ketones containing furan, thiophene, chroman and thiochroman moieties were successfully reduced in the presence of 1 - 10 mol % of spiroaminoborate ester 1 with different borane sources to afford non-racemic alcohols in up to 99% ee. In addition, modest enantioselectivity, around 80% ee, was achieved in the reduction of linear α,β-unsaturated heteroaryl ketones.
authors.affiliation: Department of Chemistry, University of Puerto Rico-Humacao, CUH Station Humacao, Puerto Rico 00791, USA.
authors.forename: Viatcheslav
authors.initials: V
authors.lastname: Stepanenko
authors.forename: Melvin
authors.initials: M
authors.lastname: De Jesús
authors.forename: Wildeliz
authors.initials: W
authors.lastname: Correa
authors.forename: Lorianne
authors.initials: L
authors.lastname: Bermúdez
authors.forename: Cindybeth
authors.initials: C
authors.lastname: Vázquez
authors.forename: Irisbel
authors.initials: I
authors.lastname: Guzmán
authors.forename: Margarita
authors.initials: M
authors.lastname: Ortiz-Marciales