Depressive symptoms and C-reactive protein are not associated in a population-based sample of adolescents.
BACKGROUND
One potential mechanism to explain the association of depression and cardiovascular mortality is through increased inflammation. Adolescents typically have high levels of depressive symptoms, but the association of depression and levels of inflammation has not been examined within this age group.


OBJECTIVE
The objective was to study the association between high-sensitivity C-reactive protein (hs-CRP) concentrations and depressive symptoms in youth.


METHODS
Data were available for 1,535 adolescents aged 13 and 16 years obtained in a province-wide survey of a representative sample of youth in Quebec, Canada in 1999. Data on depressive symptoms were collected in self-report questionnaires. Participants provided a fasting blood sample, and anthropometric measures were undertaken by trained technicians.


RESULTS
For each unit increase in the depression score, the odds ratio for elevated hs-CRP (i.e., > or =90th percentile value of the age- and sex-specific CRP distribution) was 1.06 (95% confidence interval 0.79, 1.42) after adjustment for age, sex, ever smoked, language, body mass index, physical inactivity, use of medication, total cholesterol concentration, triglycerides concentration, and systolic blood pressure.


CONCLUSIONS
These data do not support an association between depressive symptoms and elevated CRP in adolescents.
Chaiton
Michael
M
Department of Public Health Sciences, University of Toronto, T509 33 Russell St., Toronto, ON, Canada, M5S 2S1. michael.chaiton@utoronto.ca
O'Loughlin
Jennifer
J
Karp
Igor
I
Lambert
Marie
M
D000293:Adolescent; D000367:Age Factors; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D002784:Cholesterol / Q000097:blood; D016001:Confidence Intervals; D003863:Depression / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D009043:Motor Activity; D016017:Odds Ratio; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
D014280:Triglycerides; D002097:C-Reactive Protein; D002784:Cholesterol