StIKKing together: do multiple IKK pathways cooperate in the DNA-damage response?
Although IKK-related kinases are known to augment immune pathways, their importance to DNA-damage response has not been previously elucidated; in this issue of Molecular Cell, Renner et al. (2010) show that genotoxic stress requires SUMOylated IKKvarepsilon to regulate NF-kappaB transcription and cell survival.
Allison
David F
DF
Department of Biochemistry and Molecular Genetics, Box 800733, University of Virginia, Charlottesville, VA 22908, USA.
Mayo
Marty W
MW
D017209:Apoptosis; D004249:DNA Damage; D051550:I-kappa B Kinase / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D025842:SUMO-1 Protein / Q000378:metabolism; D015398:Signal Transduction
D025842:SUMO-1 Protein; D051550:I-kappa B Kinase