Phototransduction: keep an eye out for acid-labile TRPs.
Our mechanistic understanding of phototransduction in the Drosophila eye is still rudimentary. Recent work demonstrates that a combination of phosphoinositide depletion and microvillar acidification is sufficient to activate light-sensitive TRPC channels.
Gudermann
Thomas
T
Ludwig-Maximilians-Universitaet Muenchen, Walther-Straub-Institut of Pharmacology and Toxicology, Goethestr. 33, 80336 Munich, Germany. Thomas.Gudermann@lrz.unimuenchen.de
Mederos y Schnitzler
Michael
M
D000818:Animals; D000136:Acid-Base Equilibrium; D004330:Drosophila / Q000502:physiology; D055537:Light Signal Transduction / Q000502:physiology; D008954:Models, Biological; D005810:Multigene Family / Q000235:genetics; D017956:Photoreceptor Cells, Invertebrate / Q000378:metabolism; D050051:Transient Receptor Potential Channels / Q000145:classification / Q000235:genetics / Q000378:metabolism
D050051:Transient Receptor Potential Channels