Manipulating the chemokine system: therapeutic perspectives for atherosclerosis.
Atherosclerosis is a chronic inflammatory disease characterized by the presence of lesions in the walls of major arteries. The progression of these plaques is driven by the infiltration of leukocytes, a process that is regulated by chemokines. Therefore, the chemokine system presents an attractive therapeutic target for the prevention and treatment of atherosclerosis. This review discusses recent advances in the field, highlights novel opportunities for therapeutic intervention, and considers both the advantages and disadvantages of intervening in the chemokine system.
Koenen
Rory R
RR
University Hospital Aachen, Institute for Molecular Cardiovascular Research Medical Faculty, Rheinisch-Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
Weber
Christian
C
D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy* / Q000378:metabolism*; D002465:Cell Movement / Q000187:drug effects; D018925:Chemokines / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000166:cytology / Q000187:drug effects
D018925:Chemokines