title: Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit.
abstract: The design, synthesis and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) derivatives are detailed representing analogs of duocarmycin SA containing an oxazole replacement for the fused pyrrole found in the alkylation subunit.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: Kristopher E
authors.initials: KE
authors.lastname: Boyle
authors.forename: Karen S
authors.initials: KS
authors.lastname: MacMillan
authors.forename: David A
authors.initials: DA
authors.lastname: Ellis
authors.forename: James P
authors.initials: JP
authors.lastname: Lajiness
authors.forename: William M
authors.initials: WM
authors.lastname: Robertson
authors.forename: Dale L
authors.initials: DL
authors.lastname: Boger
mesh_terms: D000477:Alkylating Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000478:Alkylation; D000080890:Duocarmycins; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010080:Oxazoles / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000477:Alkylating Agents; D000080890:Duocarmycins; D007211:Indoles; D010080:Oxazoles; D011758:Pyrroles; C066098:duocarmycin SA