Surface modification of biomedical and dental implants and the processes of inflammation, wound healing and bone formation.
Bone adaptation or integration of an implant is characterized by a series of biological reactions that start with bone turnover at the interface (a process of localized necrosis), followed by rapid repair. The wound healing response is guided by a complex activation of macrophages leading to tissue turnover and new osteoblast differentiation on the implant surface. The complex role of implant surface topography and impact on healing response plays a role in biological criteria that can guide the design and development of future tissue-implant surface interfaces.
Stanford
Clark M
CM
Dows Institute for Dental Research, University of Iowa, 52242, USA. Clark-Stanford@uiowa.edu
D015921:Dental Implants / Q000009:adverse effects; D006801:Humans; D007249:Inflammation; D010012:Osteogenesis; D019736:Prostheses and Implants / Q000009:adverse effects; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry; D014945:Wound Healing
D015921:Dental Implants; D014025:Titanium