[The diagnostics of subarachnoid hemorrhage and warning leaks by spectrophotometric analysis of the cerebrospinal fluid].
Subarachnoid hemorrhage typically starts abruptly with an intense ("thunderclap") headache but sometimes the symptoms are atypical. The mortality is approximately 50%. Correct immediate diagnosis is important because the hemorrhage is usually caused by a treatable aneurysm. Computer tomography (CT) is the principal diagnostic method on arrival to the emergency room. If the CT is negative and the situation remains unclear, examination of the cerebrospinal fluid is essential and should entail analysis of heme pigments, especially in warning leaks and after delayed admission. Only spectrophotometry of the sample is sensitive enough and should replace visual inspection.
Lindsberg
Perttu J
PJ
HUS:n neurologian klinikka ja Helsingin yliopisto, molekyylineurologian tutkimusohjelma, Biomedicum Helsinki.
Uotila
Lasse
L
D006261:Headache / Q000134:cerebrospinal fluid / Q000000981:diagnostic imaging; D006801:Humans; D013053:Spectrophotometry / Q000379:methods*; D013345:Subarachnoid Hemorrhage / Q000134:cerebrospinal fluid* / Q000000981:diagnostic imaging / Q000401:mortality; D014057:Tomography, X-Ray Computed