title: Differential effects of Co(III), Ni(II), and Ru(III) amine complexes on Sindbis virus.
abstract: Transition metal complexes [Co(cyclen)(NH(3))(2)](ClO(4))(3)H(2)O (cyclen=1,4,7,10-tetraazacyclododecane) (2), [Co(NH(3))(5)(OH(2))](CF(3)SO(3))(3) (3) [Ni(NH(3))(6)]Br(2) (4) and [Ru(NH(3))(6)]Cl(3) (5) were tested against Sindbis infected baby hamster kidney (BHK) cells and show differential effects from the previously reported anti-viral complex [Co(NH(3))(6)]Cl(3) (1). The macrocyclic complex 2 and labile aqua complex 3 show either no or little effect on the survival on Sindbis virus-infected cells as compared to that for 1, which show a monotonic increase in % BHK cell survival. Nickel and ruthenium ammine complexes 4 and 5 had a moderate influence of cell survival. While the results showed some anti-viral activity for some of the structural variations, it appears that 1, with its potential to be a broad-spectrum anti-viral compound, occupies a unique position in its ability to both significantly enhance cell survival and to decrease viral expression of infected cells. We also show that 1 also shows anti-viral activity against Adenovirus lending support to the broad-spectrum potential of this complex.
authors.affiliation: Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC 20375, USA.
authors.forename: D
authors.initials: D
authors.lastname: Andrew Knight
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Hickey
authors.forename: Jason E
authors.initials: JE
authors.lastname: Bongard
authors.forename: Dzung C
authors.initials: DC
authors.lastname: Thach
authors.forename: R
authors.initials: R
authors.lastname: Yngard
authors.forename: Eddie L
authors.initials: EL
authors.lastname: Chang
mesh_terms: D000588:Amines / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D002460:Cell Line / Q000187:drug effects / Q000821:virology; D003035:Cobalt / Q000737:chemistry / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology; D006224:Cricetinae; D003412:Cricetulus; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology; D010084:Oxidation-Reduction; D012428:Ruthenium / Q000737:chemistry / Q000494:pharmacology; D012845:Sindbis Virus / Q000187:drug effects*; D028561:Transition Elements / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000588:Amines; D056831:Coordination Complexes; D028561:Transition Elements; D003035:Cobalt; D009532:Nickel; D012428:Ruthenium