title: SAPHO syndrome in an adult with ulcerative colitis responsive to intravenous pamidronate.
abstract: Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome is a rare group of sterile, inflammatory osteoarticular disorders classically associated with skin lesions. It is occasionally associated with enteropathic disease such as ulcerative colitis. We present a 39-year-old patient with chronic ulcerative colitis who developed enteropathic SAPHO and responded well to pamidronate. We discuss the clinicopathological features with particular attention to bone pathology, and perform a literature review of this fascinating syndrome.
authors.affiliation: Department of Rheumatology, Musgrove Park Hospital, Taunton, TA1 5DA, UK. keith@siau.org
authors.forename: Keith
authors.initials: K
authors.lastname: Siau
authors.forename: Cathy J
authors.initials: CJ
authors.lastname: Laversuch
mesh_terms: D020083:Acquired Hyperostosis Syndrome / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology; D000328:Adult; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D003093:Colitis, Ulcerative / Q000150:complications*; D004164:Diphosphonates / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008159:Lumbar Vertebrae / Q000473:pathology; D008279:Magnetic Resonance Imaging; D000077268:Pamidronate
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D000077268:Pamidronate