title: Machine perfusion preservation for kidney grafts with a high creatinine from uncontrolled donation after cardiac death.
abstract: BACKGROUND
  This study evaluated the usefulness of machine perfusion preservation parameters as selection criteria for donation after cardiac arrest (DCD) with high creatinine level. The aim of this study is to evaluate to whether DCD donor >50 years old and with high creatinine are acceptable.
  
  
  METHODS
  We examined 17 kidneys from uncontrolled DCD who showed creatinine levels >3.0 mg/dL before procurement. The study included the following two groups: group 1 (n = 9), donor age <50 years old versus group 2 (n = 8), donor age >50 years old.
  
  
  RESULTS
  There were no significant differences in donors or preservation conditions among the 2 groups, including age, terminal creatinine, warm ischemic time, cold perfusion time, and total ischemic time. A greater resistance of 47.9 mmHg/mL per min/g was observed among group 2, compared with 42.5 mmHg/mL per min/g in group 1. A shorter ATN period (8.2 days) was noted in group 1, compared with 21.2 days for group 2. The flow rate (mL/g/min) was not significantly different between the two groups. The best-Cr level was 1.22 mg/dL in group 1 and 1.94 mg/dL in group 2.
  
  
  CONCLUSIONS
  Machine perfusion flow was a reliable indicator of graft viability in uncontrolled DCD, particularly kidneys with high creatinine level. Even older donors were acceptable if the machine perfusion preservation parameters such as flow rate and pressure were acceptable; however, they may show severe delayed graft function.
authors.affiliation: The 5th Department of Surgery, Hachioji Medical Center of Tokyo Medical University, Tokyo, Japan. mtn@tokyo-med.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Matsuno
authors.forename: Y N O
authors.initials: YN
authors.lastname: Konno
authors.forename: Y
authors.initials: Y
authors.lastname: Jyojima
authors.forename: I
authors.initials: I
authors.lastname: Akashi
authors.forename: H
authors.initials: H
authors.lastname: Iwamoto
authors.forename: K
authors.initials: K
authors.lastname: Hama
authors.forename: T
authors.initials: T
authors.lastname: Hiirano
authors.forename: T
authors.initials: T
authors.lastname: Nagao
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D003404:Creatinine / Q000097:blood; D003643:Death; D006801:Humans; D007668:Kidney / Q000502:physiology* / Q000503:physiopathology; D016030:Kidney Transplantation / Q000473:pathology / Q000502:physiology*; D008875:Middle Aged; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions; D018579:Patient Selection; D010477:Perfusion; D014019:Tissue Donors / Q000706:statistics & numerical data*; D009927:Tissue and Organ Procurement / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D019188:Organ Preservation Solutions; D003404:Creatinine