title: Cypermethrin and lambda-cyhalothrin induced in vivo alterations in nucleic acids and protein contents in a freshwater catfish, Clarias batrachus (Linnaeus; Family-Clariidae).
abstract: The fresh water fish, Clarias batrachus, were exposed to sub-acute concentrations of cypermethrin and lambda-cyhalothrin for 96 h to assess their impact on the levels of nucleic acids and protein in different organs of fish. DNA content was found almost unchanged with a single exception of liver, which showed significant increment in the levels of DNA in response to the separate treatments of both compounds. Both RNA and protein contents declined in brain, liver, and muscle while sharp increase was observed in gills. However, in kidney, RNA contents depicted significant enhancement only at higher concentrations, with initial decline at lower concentrations. The trends of alterations in RNA/DNA and protein/DNA ratios were quite similar to the corresponding results explained above for RNA and protein. The results clearly indicated that both of these pyrethroids exerted their effects at transcriptional and translational levels while DNA synthesis was found to be unaffected by these compounds with an exception of liver.
authors.affiliation: Biochemistry Laboratory, Department of Zoology, University of Allahabad, Allahabad, India.
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: Bechan
authors.initials: B
authors.lastname: Sharma
authors.forename: Ravi S
authors.initials: RS
authors.lastname: Pandey
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002397:Catfishes / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D005618:Fresh Water; D005880:Gills / Q000378:metabolism; D007306:Insecticides / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D009570:Nitriles / Q000494:pharmacology*; D009696:Nucleic Acids / Q000378:metabolism*; D009928:Organ Specificity; D011506:Proteins / Q000378:metabolism*; D011722:Pyrethrins / Q000494:pharmacology*; D012313:RNA / Q000378:metabolism; D014874:Water Pollutants, Chemical / Q000494:pharmacology*
chemical_list: D007306:Insecticides; D009570:Nitriles; D009696:Nucleic Acids; D011506:Proteins; D011722:Pyrethrins; D014874:Water Pollutants, Chemical; C017160:cypermethrin; D012313:RNA; D004247:DNA; C037304:cyhalothrin