Racial disparities in awareness and treatment of atrial fibrillation: the REasons for Geographic and Racial Differences in Stroke (REGARDS) study.
OBJECTIVE
Warfarin reduces stroke risk by approximately 60% in patients with atrial fibrillation (AF). Differences in awareness and treatment of AF may contribute to racial and geographic disparities in stroke mortality. The objective was to examine predictors of awareness of the diagnosis of AF and treatment with warfarin.


METHODS
REasons for Geographic and Racial Differences in Stroke (REGARDS) is a national, population-based, longitudinal study of 30,239 blacks and whites > or = 45 years old with oversampling from blacks and the southeastern stroke belt states. Participants were enrolled January 2003 to October 2007. Data were collected using telephone interview, in-home evaluation, and self-administered questionnaires. The main variable of awareness of AF was defined by a positive answer to "Has a doctor or other health professional ever told you that you had atrial fibrillation?" and whether there was evidence of treatment on the basis of an in-home medications inventory.


RESULTS
From baseline electrocardiograms, 432 individuals (88 black and 344 white) had AF. Of these, 88% (360 of 409) had at least 1 additional CHADS2 stroke risk factor and 60% (258 of 432) were aware of their AF. The odds of blacks being aware of their AF were one third that of whites (OR=0.32; 95% CI: 0.20 to 0.52). Among those aware, the odds of blacks being treated with warfarin were only one fourth as great as whites (OR=0.28; 0.13 to 0.60).


CONCLUSIONS
Blacks were less likely than whites to be aware of having AF or to be treated with warfarin. Potential reasons for the racial disparity in warfarin treatment warrant further investigation.
Meschia
James F
JF
Department of Neurology, Mayo Clinic, Jacksonville, FL 32224, USA. Meschia.james@mayo.edu
Merrill
Peter
P
Soliman
Elsayed Z
EZ
Howard
Virginia J
VJ
Barrett
Kevin M
KM
Zakai
Neil A
NA
Kleindorfer
Dawn
D
Safford
Monika
M
Howard
George
G
D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy* / Q000208:ethnology* / Q000523:psychology; D044383:Black People / Q000208:ethnology* / Q000523:psychology / Q000706:statistics & numerical data; D004562:Electrocardiography; D005260:Female; D054624:Health Status Disparities; D006801:Humans; D007407:Interviews as Topic; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D044469:Racial Groups; D012044:Regression Analysis; D012307:Risk Factors; D020521:Stroke / Q000208:ethnology / Q000209:etiology / Q000517:prevention & control* / Q000523:psychology; D011795:Surveys and Questionnaires; D014859:Warfarin / Q000627:therapeutic use*; D044465:White People / Q000208:ethnology* / Q000523:psychology / Q000706:statistics & numerical data
D000925:Anticoagulants; D014859:Warfarin