Synthesis of a quinolone library from ynones.
A library of 72 quinolones was synthesized from substituted anthranilic acids, using ynone intermediates. These masked β-dicarbonyl synthons allowed cyclization under milder conditions than previously reported quinolone syntheses.
Ward
Timothy R
TR
Department of Medicinal Chemistry and Center for Methodology and Library Development, University of Kansas, 1251 Wescoe Hall Drive, Lawrence Kansas 66045, USA; Department of Medicinal Chemistry and the Institute for Therapeutics Discovery and Development, University of Minnesota, 717 Delaware Street SE, Minneapolis, Minnesota 55414, USA.
Turunen
Brandon J
BJ
Haack
Torsten
T
Neuenswander
Benjamin
B
Shadrick
William
W
Georg
Gunda I
GI