title: Exercise, physiological function, and the selection of participants for aging research.
abstract: BACKGROUND
  Regular and vigorous exercisers appear to be the logical choice for studying the inherent aging process as they are essentially free from the complications of disuse. Cross-sectional studies of aging tend to depict an essentially smooth and progressive decrement of physiological function with increasing chronological age. On closer examination of such data, it is seen that although the young have high functional values and the very old low, between these limits, values are widely scattered.
  
  
  METHODS
  We have reevaluated published data from a meta-analysis of 242 studies on men and from a similar study on women. From both data sets, where VO2max was plotted against chronological age, we stratified the VO2max values into bandwidth intervals of 5 ml/kg/minute and then allocated data points to their respective bandwidth irrespective of chronological age.
  
  
  RESULTS
  When replotted into bandwidths of functional equivalence, these data show that at the extremes of function, the young are separated from the old. Between these values, each functional bandwidth accommodates a wide age range. The decrement in function with chronological age is not smooth or well defined.
  
  
  CONCLUSIONS
  We suggest that participants for research into healthy aging should be initially segregated into bands of functionally equivalent VO2max values irrespective of their chronological age. Subsequently, other physiological measurements should be made on every participant in the band in order to begin to define the physiological profile of the participants. By conducting longitudinal studies on every individual, it will be possible to chart the physiological history of each participant through various ages. Segregating participants into cohorts of functional equivalence with data handling blinded to chronological age may be of great utility in increasing our understanding of the inherent aging process.
authors.affiliation: Division of Applied Biomedical Research, King's College London, Shepherd's House, Guy's Campus, London SE1 1UL, UK.
authors.forename: Norman R
authors.initials: NR
authors.lastname: Lazarus
authors.forename: Stephen D R
authors.initials: SD
authors.lastname: Harridge
mesh_terms: D000375:Aging; D056352:Athletes; D003430:Cross-Sectional Studies; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D010101:Oxygen Consumption