title: Incidental Lewy body disease: clinical comparison to a control cohort.
abstract: Limited clinical information has been published on cases pathologically diagnosed with incidental Lewy body disease (ILBD). Standardized, longitudinal movement and cognitive data was collected on a cohort of subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program. Of 277 autopsied subjects who had antemortem clinical evaluations within the previous 3 years, 76 did not have Parkinson's disease, a related disorder, or dementia of which 15 (20%) had ILBD. Minor extrapyramidal signs were common in subjects with and without ILBD. Cognitive testing revealed an abnormality in the ILBD group in the Trails B test only. ILBD cases had olfactory dysfunction; however, sample size was very small. This preliminary report revealed ILBD cases have movement and cognitive findings that for the most part were not out of proportion to similarly assessed and age-similar cases without Lewy bodies. Larger sample size is needed to have the power to better assess group differences.
authors.affiliation: Parkinson's Disease and Movement Disorders Center, Mayo Clinic, Scottsdale, Arizona 85259, USA. cadler@mayo.edu
authors.forename: Charles H
authors.initials: CH
authors.lastname: Adler
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Connor
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Hentz
authors.forename: Marwan N
authors.initials: MN
authors.lastname: Sabbagh
authors.forename: John N
authors.initials: JN
authors.lastname: Caviness
authors.forename: Holly A
authors.initials: HA
authors.lastname: Shill
authors.forename: Brie
authors.initials: B
authors.lastname: Noble
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Beach
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D009483:Neuropsychological Tests; D000857:Olfaction Disorders / Q000175:diagnosis; D010300:Parkinson Disease / Q000175:diagnosis* / Q000503:physiopathology; D012189:Retrospective Studies; D012720:Severity of Illness Index