title: Relevance of the site of assisted hatching in thawed human blastocysts: a preliminary report.
abstract: Preliminary data from a prospective randomized study of assisted hatching (AH) of thawed human blastocysts demonstrated that the rate of complete hatching was significantly higher for AH performed near the inner cell mass (ICM) than for AH at the side opposite to the ICM. This suggests the existence of polarity in the hatching process in human blastocysts, which requires further evaluation.
authors.affiliation: Osaka New ART Clinic and New ART Research Center, Osaka, Japan.
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Miyata
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Matsubayashi
authors.forename: Noriko
authors.initials: N
authors.lastname: Fukutomi
authors.forename: Junko
authors.initials: J
authors.lastname: Matsuba
authors.forename: Azusa
authors.initials: A
authors.lastname: Koizumi
authors.forename: Tatsuhiro
authors.initials: T
authors.lastname: Tomiyama
mesh_terms: D000328:Adult; D001755:Blastocyst / Q000166:cytology* / Q000502:physiology / Q000648:ultrastructure; D015925:Cryopreservation; D046149:Embryo Culture Techniques / Q000379:methods*; D004624:Embryo Transfer; D005260:Female; D005615:Freezing; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D008297:Male; D010865:Pilot Projects; D011247:Pregnancy; D018873:Pregnancy Rate; D027724:Reproductive Techniques, Assisted; D015044:Zona Pellucida / Q000502:physiology