title: Synthesis of ansa1-cytidines.
abstract: The synthesis of new ansa(1)-N(4)5-ethylene cytidines such as 3-ss-D-ribofuranosyl-3,5,6,7-tetrahydro-2H-pyrrolo[2,3-d]pyrimidin-2-one is described and the problems connected with the ring closure to the desired tetrahydro-2H-pyrrolo[2,3-d]pyrimidine base discussed. The lack of biological activities of the new ansa(1-) cytidines is furthermore commented on.
authors.affiliation: Medicinal Chemistry, The former Schering AG, now Bayer Schering Pharma AG, Berlin, Germany.
authors.forename: Konrad
authors.initials: K
authors.lastname: Krolikiewicz
authors.forename: Martina
authors.initials: M
authors.lastname: Schäfer
authors.forename: Helmut
authors.initials: H
authors.lastname: Vorbrüggen
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D003562:Cytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008958:Models, Molecular
chemical_list: D000970:Antineoplastic Agents; D003562:Cytidine