title: The application of vinylogous iminium salt derivatives to efficient formal syntheses of the marine akaloids lamellarin G trimethyl ether and ningalin B.
abstract: Studies directed at the synthesis of lamellarin G trimethyl ether and ningalin B via vinylogous iminium salt derivatives are described. The successful strategy relies on the formation of a 2,4-disubstituted pyrrole or a 1,2,3,4-tetrasubstituted pyrrole from a vinylogous iminium salt or vinylogous iminium salt derivative. Subsequent transformations of these highly substituted pyrroles lead to efficient and regiocontrolled formal syntheses of the respective pyrrole containing natural products.
authors.affiliation: Department of Chemistry, University of Richmond, Richmond, VA 23173, USA.
authors.forename: John T
authors.initials: JT
authors.lastname: Gupton
authors.forename: Benjamin C
authors.initials: BC
authors.lastname: Giglio
authors.forename: James E
authors.initials: JE
authors.lastname: Eaton
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Rieck
authors.forename: Kristin L
authors.initials: KL
authors.lastname: Smith
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Keough
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Barelli
authors.forename: Lauren T
authors.initials: LT
authors.lastname: Firich
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Hempel
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Smith
authors.forename: Rene P F
authors.initials: RP
authors.lastname: Kanters