title: MRI demonstrates restricted diffusion in distal optic nerve in atypical optic neuritis.
abstract: A 4-year-old healthy girl with acute visual loss in the right eye had ophthalmoscopic evidence of a swollen optic disc combined with central retinal artery and vein occlusion in the affected eye. MRI showed that the intraorbital optic nerve on the affected side was thickened and enhancing. Diffusion-weighted imaging showed restricted diffusion in the distal intraorbital segment of the optic nerve, consistent with infarction attributed to compression or inflammation of the vessels serving the optic nerve and retina. Although such clinical phenomena have been described previously, this is the first patient to demonstrate restricted diffusion in an inflammatory optic neuropathy. The presence of restricted diffusion is helpful in excluding a neoplastic cause of a thickened optic nerve.
authors.affiliation: Ophthalmology Department, Tel Aviv Sourasky Medical Center, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Oriel
authors.initials: O
authors.lastname: Spierer
authors.forename: Liat
authors.initials: L
authors.lastname: Ben Sira
authors.forename: Igal
authors.initials: I
authors.lastname: Leibovitch
authors.forename: Anat
authors.initials: A
authors.lastname: Kesler
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D008775:Methylprednisolone / Q000627:therapeutic use; D009898:Optic Disk / Q000473:pathology; D009900:Optic Nerve / Q000473:pathology*; D009902:Optic Neuritis / Q000175:diagnosis* / Q000503:physiopathology; D014794:Visual Fields / Q000502:physiology
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone