Synthesis, antibacterial and antifungal activities of some carbazole derivatives.
A series of N-substituted carbazole derivatives were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Bacillus proteus, Candida albicans and Aspergillus fumigatus by two fold serial dilution technique. Some of the synthesized compounds displayed comparable or even better antibacterial and antifungal activities than reference drugs fluconazole, chloramphenicol and norfloxacin against tested strains.
Zhang
Fei-Fei
FF
School of Chemistry and Chemical Engineering, Southwest University, Chongqing, China.
Gan
Lin-Ling
LL
Zhou
Cheng-He
CH
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001232:Aspergillus fumigatus / Q000187:drug effects; D001419:Bacteria / Q000145:classification / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002227:Carbazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002227:Carbazoles