Use of central venous catheter and peripheral venous catheter as risk factors for nosocomial bloodstream infection in very-low-birth-weight infants.
OBJECTIVE
To describe the relationship between the use of central and peripheral venous catheters and the risk of nosocomial, primary, laboratory-confirmed bloodstream infection (BSI) for neonates with a birth weight less than 1,500 g (very-low-birth-weight [VLBW] infants).


METHODS
Cox proportional hazard regression analysis with time-dependent variable was used to determine the risk factors for the occurrence of BSI in a cohort of VLBW infants. We analyzed previously collected surveillance data from the German national nosocomial surveillance system for VLBW infants. All VLBW infants in 22 participating neonatal departments who had a complete daily record of patient information were included.


RESULTS
Of 2,126 VLBW infants, 261 (12.3%) developed a BSI. The incidence density for BSI was 3.3 per 1,000 patient-days. The multivariate analysis identified the following significant independent risk factors for BSI: lower birth weight (hazard ratio [HR], 1.1-2.2), vaginal delivery (HR, 1.5), central venous catheter use (HR, 6.2) or peripheral venous catheter use (HR, 6.0) within 2 days before developing BSI, and the individual departments (HR, 0.0-4.6).


CONCLUSIONS
After adjusting for other risk factors, use of peripheral venous catheter and use of central venous catheter were significantly related to occurrence of BSI in VLBW infants.
Geffers
Christine
C
National Reference Center for the Surveillance of Nosocomial Infections, Institute for Hygiene and Environmental Medicine, Charité-University Medicine Berlin, Berlin, Germany. christine.geffers@charite.de
Gastmeier
Anne
A
Schwab
Frank
F
Groneberg
Katrin
K
Rüden
Henning
H
Gastmeier
Petra
P
D016470:Bacteremia / Q000175:diagnosis / Q000382:microbiology; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000706:statistics & numerical data; D002406:Catheterization, Peripheral / Q000009:adverse effects* / Q000706:statistics & numerical data; D002408:Catheters, Indwelling / Q000009:adverse effects; D003428:Cross Infection / Q000175:diagnosis* / Q000382:microbiology / Q000821:virology; D005260:Female; D016469:Fungemia / Q000175:diagnosis / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008297:Male; D016016:Proportional Hazards Models; D012307:Risk Factors; D014766:Viremia / Q000175:diagnosis / Q000821:virology