title: A microfluidic approach for high-throughput droplet interface bilayer (DIB) formation.
abstract: We present a simple, automated method for high-throughput formation of droplet interface bilayers (DIBs) in a microfluidic device. We can form complex DIB networks that are able to fill predefined three dimensional architectures. Moreover, we demonstrate the flexibility of the system by using a variety of lipids including 1,2-diphytanoyl-sn-glycero-3-phosphocholine (DPhPC) and 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC).
authors.affiliation: Department of Chemistry, Imperial College London, Exhibition Road, South Kensington, London, UKSW7 2AZ.
authors.forename: C E
authors.initials: CE
authors.lastname: Stanley
authors.forename: K S
authors.initials: KS
authors.lastname: Elvira
authors.forename: X Z
authors.initials: XZ
authors.lastname: Niu
authors.forename: A D
authors.initials: AD
authors.lastname: Gee
authors.forename: O
authors.initials: O
authors.lastname: Ces
authors.forename: J B
authors.initials: JB
authors.lastname: Edel
authors.forename: A J
authors.initials: AJ
authors.lastname: Demello
mesh_terms: D019793:Fluorescein / Q000737:chemistry; D008051:Lipid Bilayers / Q000737:chemistry*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation* / Q000379:methods*; D009821:Oils / Q000737:chemistry; D010713:Phosphatidylcholines / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D008051:Lipid Bilayers; D009821:Oils; D010713:Phosphatidylcholines; D014867:Water; C021016:1,2-diphytanoylphosphatidylcholine; C017251:1,2-oleoylphosphatidylcholine; D019793:Fluorescein