Suzuki-Miyaura cross-coupling reactions in aqueous media: green and sustainable syntheses of biaryls.
Carbon-carbon cross-coupling reactions are among the most important processes in organic chemistry, and Suzuki-Miyaura reactions are among the most widely used protocols for the formation of carbon-carbon bonds. These reactions are generally catalyzed by soluble palladium complexes with various ligands. However, the use of toxic organic solvents remains a scientific challenge and an aspect of economical and ecological relevance. This Review will summarize various recently developed significant methods by which the Suzuki-Miyaura coupling was conducted in aqueous media, and analyzes if they are "real green" protocols.
Polshettiwar
Vivek
V
KAUST Catalysis Center (KCC), King Abdullah University of Science and Technology, Thuwal 23955, Saudi Arabia. vivek.pol@kaust.edu.sa
Decottignies
Audrey
A
Len
Christophe
C
Fihri
Aziz
A
D055772:Green Chemistry Technology / Q000379:methods*; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis* / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D010720:Phosphines / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D014867:Water / Q000737:chemistry*
D006841:Hydrocarbons, Aromatic; D010720:Phosphines; D014867:Water; D010165:Palladium; D012822:Silicon Dioxide