title: Contribution of dopamine D1 and D2 receptors to amygdala activity in human.
abstract: Several animal studies have demonstrated functional roles of dopamine (DA) D1 and D2 receptors in amygdala activity. However, the contribution of DA D1 and D2 receptors to amygdala response induced by affective stimuli in human is unknown. To investigate the contribution of DA receptor subtypes to amygdala reactivity in human, we conducted a multimodal in vivo neuroimaging study in which DA D1 and D2 receptor bindings in the amygdala were measured with positron emission tomography (PET), and amygdala response induced by fearful faces was assessed by functional magnetic resonance imaging (fMRI) in healthy volunteers. We used multimodality voxelwise correlation analysis between fMRI signal and DA receptor binding measured by PET. DA D1 binding in the amygdala was positively correlated with amygdala signal change in response to fearful faces, but DA D2 binding in the amygdala was not related to amygdala signal change. DA D1 receptors might play a major role in enhancing amygdala response when sensory inputs are affective.
authors.affiliation: Department of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan. hidehiko@nirs.go.jp
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Takahashi
authors.forename: Harumasa
authors.initials: H
authors.lastname: Takano
authors.forename: Fumitoshi
authors.initials: F
authors.lastname: Kodaka
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Arakawa
authors.forename: Makiko
authors.initials: M
authors.lastname: Yamada
authors.forename: Tatsui
authors.initials: T
authors.lastname: Otsuka
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Hirano
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Kikyo
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Okubo
authors.forename: Motoichiro
authors.initials: M
authors.lastname: Kato
authors.forename: Takayuki
authors.initials: T
authors.lastname: Obata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Suhara
mesh_terms: D000328:Adult; D000339:Affect / Q000502:physiology*; D000679:Amygdala / Q000033:anatomy & histology / Q000000981:diagnostic imaging / Q000502:physiology*; D001667:Binding, Competitive / Q000502:physiology; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology; D004298:Dopamine / Q000378:metabolism*; D004644:Emotions / Q000502:physiology*; D005239:Fear / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology; D010775:Photic Stimulation; D049268:Positron-Emission Tomography; D017447:Receptors, Dopamine D1 / Q000378:metabolism*; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D021641:Recognition, Psychology / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*; D055815:Young Adult
chemical_list: D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D004298:Dopamine