Current advancement in radiation therapy for uterine cervical cancer.
Radiation therapy is one of the effective curative treatments for uterine cervical cancer. However poor clinical results for the advanced stages require further improvement of the treatment. Intensive studies on basic and clinical research have been made to improve local control, primarily important for long term survival in radiation therapy. Regarding current advancement in radiation therapy for uterine cervical cancer, the following three major subjects are pointed out; technological development to improve dose distribution by image guided radiation therapy technology, the concomitant anticancer chemotherapy with combination of radiation therapy, and radiation biological assessment of the radiation resistance of tumors. The biological factors overviewed in this article include hypoxia relating factors of HIF-1alpha, SOD, cell cycle parameters of pMI, proliferation factors of Ki67, EGFR, cerbB2, COX-2, cycle regulation proteins p53, p21, apoptosis regulation proteins Bcl2 and Bax and so on. Especially, the variety of these radiation biological factors is important for the selection of an effective treatment method for each patient to maximize the treatment benefit.
Nakano
Takashi
T
Department of Radiation Oncology, Gunma University Graduate school of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, Japan. tnakano@med.gunma-u.ac.jp
Ohno
Tatsuya
T
Ishikawa
Hitoshi
H
Suzuki
Yoshiyuki
Y
Takahashi
Takeo
T
D014408:Biomarkers, Tumor / Q000032:analysis*; D003952:Diagnostic Imaging / Q000639:trends*; D005260:Female; D005544:Forecasting; D006801:Humans; D015336:Molecular Probe Techniques / Q000639:trends*; D011881:Radiotherapy, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000639:trends*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000532:radiotherapy*
D014408:Biomarkers, Tumor