[Polypronuclear zygotes and clinical pregnancy after IVF].
OBJECTIVE
To study the relationship between the percentage of polypronuclear zygotes and clinical pregnancy following IVF.


METHODS
We collected the data of 954 IVF cycles, and according the percentage of polypronuclear zygotes in the IVF cycles, allocated them to Groups A (without polypronuclear zygotes) , B (with < 30% polypronuclear zygotes) and C (with > or = 30% polypronuclear zygotes). Then we analyzed the relationship between the percentage of polypronuclear zygotes and the rate of clinical pregnancy.


RESULTS
Compared with Group A, Group C showed a significantly lower rate of clinical pregnancy (43.2% vs 28. 1%, P < 0.05), while Group B exhibited a markedly higher rate (43.2% vs 52.36%, P < 0.05) and obviously decreased polypronuclear zygote formation with the increase of age (35.6% vs 24.1%, P < 0.05).


CONCLUSIONS
The percentage of polypronuclear zygotes in IVF cycles may serve as a prognostic indicator of the clinical outcome.
Yin
Hui-Rong
HR
Center of Human Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
Qian
Xiao-Qiao
XQ
Cai
Ling-Bo
LB
Feng
Ting
T
Yan
Zheng-Jie
ZJ
Ma
Long
L
Liu
Jia-Yin
JY
D000328:Adult; D000367:Age Factors; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D015053:Zygote