title: High loading fragrance encapsulation based on a polymer-blend: preparation and release behavior.
abstract: The six fragrances, camphor, citronellal, eucalyptol, limonene, menthol and 4-tert-butylcyclohexyl acetate, which represent different chemical functionalities, were encapsulated with a polymer-blend of ethylcellulose (EC), hydroxypropyl methylcellulose (HPMC) and poly(vinyl alcohol) (PV(OH)) using solvent displacement (ethanol displaced by water). The process gave >or=40% fragrance loading capacity with >or=80% encapsulation efficiency at the fragrance to polymer weight ratio of 1:1 and at initial polymer concentrations of 2000-16,000 ppm and the obtained fragrance-encapsulated spheres showed hydrodynamic diameters of less than 450 nm. The release profile of the encapsulated fragrances, evaluated by both thermal gravimetric and electronic nose techniques, indicated different release characteristics amongst the six encapsulated fragrances. Limonene showed the fastest release with essentially no retention by the nanoparticles, while eucalyptol and menthol showed the slowest release.
authors.affiliation: Chulalongkorn University, Bangkok 10330, Thailand.
authors.forename: Aurapan
authors.initials: A
authors.lastname: Sansukcharearnpon
authors.forename: Supason
authors.initials: S
authors.lastname: Wanichwecharungruang
authors.forename: Natchanun
authors.initials: N
authors.lastname: Leepipatpaiboon
authors.forename: Teerakiat
authors.initials: T
authors.lastname: Kerdcharoen
authors.forename: Sunatda
authors.initials: S
authors.lastname: Arayachukeat
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D004339:Drug Compounding / Q000379:methods; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D009822:Oils, Volatile / Q000008:administration & dosage* / Q000737:chemistry; D010316:Particle Size; D010476:Perfume / Q000008:administration & dosage* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012997:Solvents; D013499:Surface Properties
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D009822:Oils, Volatile; D010476:Perfume; D011108:Polymers; D012997:Solvents; D065347:Hypromellose Derivatives; C013517:ethyl cellulose; D002482:Cellulose; D008747:Methylcellulose