title: Effects of exercise on hepcidin response and iron metabolism during recovery.
abstract: Urinary hepcidin, inflammation, and iron metabolism were examined during the 24 hr after exercise. Eight moderately trained athletes (6 men, 2 women) completed a 60-min running trial (15-min warm-up at 75-80% HR(peak) + 45 min at 85-90% HR(peak)) and a 60-min trial of seated rest in a randomized, crossover design. Venous blood and urine samples were collected pretrial, immediately posttrial, and at 3, 6, and 24 hr posttrial. Samples were analyzed for interleukin-6 (IL-6), C-reactive protein (CRP), serum iron, serum ferritin, and urinary hepcidin. The immediate postrun levels of IL-6 and 24-hr postrun levels of CRP were significantly increased from baseline (6.9 and 2.6 times greater, respectively) and when compared with the rest trial (p < or = .05). Hepcidin levels in the run trial after 3, 6, and 24 hr of recovery were significantly greater (1.7-3.1 times) than the pre- and immediate postrun levels (p < or = .05). This outcome was consistent in all participants, despite marked variation in the magnitude of rise. In addition, the 3-hr postrun levels of hepcidin were significantly greater than at 3 hr in the rest trial (3.0 times greater, p < or = .05). Hepcidin levels continued to increase at 6 hr postrun but failed to significantly differ from the rest trial (p = .071), possibly because of diurnal influence. Finally, serum iron levels were significantly increased immediately postrun (1.3 times, p < or = .05). The authors concluded that high-intensity exercise was responsible for a significant increase in hepcidin levels subsequent to a significant increase in IL-6 and serum iron.
authors.affiliation: School of Sport Science, Exercise and Health, The University of Western Australia, Crawley, Western Australia.
authors.forename: Peter
authors.initials: P
authors.lastname: Peeling
authors.forename: Brian
authors.initials: B
authors.lastname: Dawson
authors.forename: Carmel
authors.initials: C
authors.lastname: Goodman
authors.forename: Grant
authors.initials: G
authors.lastname: Landers
authors.forename: Erwin T
authors.initials: ET
authors.lastname: Wiegerinck
authors.forename: Dorine W
authors.initials: DW
authors.lastname: Swinkels
authors.forename: Debbie
authors.initials: D
authors.lastname: Trinder
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000652:urine*; D023181:Antimicrobial Cationic Peptides / Q000652:urine*; D002097:C-Reactive Protein / Q000378:metabolism; D018592:Cross-Over Studies; D005260:Female; D005293:Ferritins / Q000097:blood; D064451:Hepcidins; D006801:Humans; D007249:Inflammation / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007501:Iron / Q000097:blood*; D000090463:Iron Deficiencies; D008297:Male; D019518:Postprandial Period; D012420:Running / Q000502:physiology*
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D015850:Interleukin-6; D002097:C-Reactive Protein; D005293:Ferritins; D007501:Iron