Acute interstitial nephritis during rifampicin therapy can be a paradoxical response: a case report.
An 18-year-old Ethiopian woman presented with debilitating back pain and high fever. X-ray examinations showed diffuse pulmonary tuberculosis and a psoas abscess. After starting rifampicin, isoniazid, ethambutol and pyrazinamide, acute interstitial nephritis developed that spontaneously recovered. According to Harrison's Online rifampicin should have been causative, but the spontaneous recovery excluded that possibility. The clinical course fit the diagnosis of a paradoxical response, for which recently risk factors have been described. Thus, a paradoxical response should be added to the list of causes of interstitial nephritis in tuberculosis patients and in such cases rifampicin could be continued.
van der Meulen
Jan
J
DIANET, Utrecht, The Netherlands. debeteredokter@gmail.com
de Jong
Gijs M T
GM
Westenend
Pieter J
PJ