title: Effectiveness of image-guided radiotherapy for laryngeal sparing in head and neck cancer.
abstract: We would like to compare the effectiveness of image-guided (IGRT) and intensity-modulated (IMRT) radiotherapy to spare the larynx in head and neck cancer patients. A retrospective review of 48 patients undergoing radiation for non-laryngeal and non-hypopharyngeal head and neck cancers. Mean laryngeal and hypopharyngeal dose was compared between 11 patients treated with IMRT and 37 patients treated with IGRT. Mean laryngeal dose was, respectively, 41.2 Gy and 22.8 Gy for the IMRT and IGRT technique (p<0.001). The radiation dose to the middle and inferior pharyngeal muscles was also significantly reduced with the IGRT technique. Mean pharyngeal dose was, respectively, 52 Gy and 26 Gy for the IMRT and IGRT technique (p=0.0001). Laryngeal sparing IGRT technique for head and neck cancer minimizes radiotherapy dose to the larynx and pharynx without sacrificing target coverage, even in the presence of neck lymph nodes.
authors.affiliation: Department of Radiation Oncology, University of Arizona, Tucson, AZ 85724-5081, USA. NamPhong.Nguyen@yahoo.com
authors.forename: Nam P
authors.initials: NP
authors.lastname: Nguyen
authors.forename: Misty
authors.initials: M
authors.lastname: Ceizyk
authors.forename: Paul
authors.initials: P
authors.lastname: Vos
authors.forename: Vincent
authors.initials: V
authors.lastname: Vinh-Hung
authors.forename: Rick
authors.initials: R
authors.lastname: Davis
authors.forename: Anand
authors.initials: A
authors.lastname: Desai
authors.forename: Dave
authors.initials: D
authors.lastname: Abraham
authors.forename: Shane P
authors.initials: SP
authors.lastname: Krafft
authors.forename: Siyoung
authors.initials: S
authors.lastname: Jang
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Watchman
authors.forename: Lars
authors.initials: L
authors.lastname: Ewell
authors.forename: Russ
authors.initials: R
authors.lastname: Hamilton
authors.forename: Lexie
authors.initials: L
authors.lastname: Smith-Raymond
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001130:Arizona / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology / Q000532:radiotherapy*; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D007830:Larynx / Q000528:radiation effects*; D008198:Lymph Nodes / Q000473:pathology / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D010609:Pharyngeal Muscles / Q000528:radiation effects; D010614:Pharynx / Q000528:radiation effects*; D011832:Radiation Injuries / Q000517:prevention & control*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D012189:Retrospective Studies