An amine-derivatized, DOTA-loaded polymeric support for Fmoc Solid Phase Peptide Synthesis.
An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional Solid Phase Peptide Synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast agent. Therefore, this synthesis methodology can facilitate Fmoc SPPS of molecular imaging contrast agents.
Yoo
Byunghee
B
Biomedical Engineering Interdisciplinary Program, The University of Arizona, Tucson AZ.
Sheth
Vipul R
VR
Pagel
Mark D
MD