Cellular functions of menin.
Since its discovery as a novel protein some 10 years ago, many cellular functions of menin have been identified. However, which ones of these relate specifically to menin's role as a tumor suppressor and which ones not remains unclear. Menin is predominantly nuclear and acts as a scaffold protein to regulate gene transcription by coordinating chromatin remodeling. It is implicated in both histone deacetylase and histone methyltransferase activity and, via the latter, regulates the expression of cell cycle kinase inhibitor and homeobox domain genes. TGF-beta family members are key cytostatic molecules and menin is a facilitator of the transcriptional activity of their signaling molecules, the Smads, thereby ensuring appropriate control of cell proliferation and differentiation.
Hendy
Geoffrey N
GN
Calcium Research Laboratory, Rm. H4.67, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, QC H3A 1A1, Canada. geoffrey.hendy@mcgill.ca
Kaji
Hiroshi
H
Canaff
Lucie
L
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins / Q000378:metabolism; D042002:Chromatin Assembly and Disassembly; D050756:Cyclin-Dependent Kinase Inhibitor Proteins / Q000378:metabolism; D004260:DNA Repair; D052236:Fanconi Anemia Complementation Group D2 Protein / Q000378:metabolism; D051858:Forkhead Transcription Factors; D020558:GTP Phosphohydrolases / Q000378:metabolism; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism; D051716:Replication Protein A / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism; D016160:Retinoblastoma Protein / Q000378:metabolism; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000378:metabolism
D018797:Cell Cycle Proteins; D050756:Cyclin-Dependent Kinase Inhibitor Proteins; C485678:DBF4 protein, human; C106158:FOXN3 protein, human; D052236:Fanconi Anemia Complementation Group D2 Protein; D051858:Forkhead Transcription Factors; C105373:MEN1 protein, human; D011518:Proto-Oncogene Proteins; D016755:Proto-Oncogene Proteins c-jun; D051716:Replication Protein A; D012097:Repressor Proteins; D016160:Retinoblastoma Protein; D016212:Transforming Growth Factor beta; C516794:RPA2 protein, human; D020558:GTP Phosphohydrolases