title: [Heparin-induced thrombocytopenia and disseminated intravascular coagulation in a patient with drug-induced pneumonia].
abstract: An 82-year-old woman was admitted to the hospital with dyspnea and fatigue. She had been given amlodipine, furosemide, candesartan, pravastatin and roxatidine acetate for two months in an other hospital. Chest CT showed patchy consolidations throughout the entire lungs. We suspected drug-induced pneumonia, and treated her with prednisolone under mechanical ventilation. The pulmonary consolidations eventually improved, but on the 15th hospital day the patient developed thrombocytopenia and disseminated intravascular coagulation (DIC). Heparin flushes had been performed since the first hospital day. After these were stopped, her platelet count became normal and the patient recovered from DIC. The clinical course, and the fact that testing for heparin-induced thrombocytopenia (HIT) antibodies was positive, supported the diagnosis of HIT and DIC. We report a rare case of HIT and DIC during treatment for drug-induced pneumonia.
authors.affiliation: Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University.
authors.forename: Kyoko
authors.initials: K
authors.lastname: Okamura
authors.forename: Keiko
authors.initials: K
authors.lastname: Kitajima
authors.forename: Takashige
authors.initials: T
authors.lastname: Maeyama
authors.forename: Satoru
authors.initials: S
authors.lastname: Fukuyama
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Inoue
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Nakanishi
mesh_terms: D000369:Aged, 80 and over; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced*; D005260:Female; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D011014:Pneumonia / Q000139:chemically induced* / Q000150:complications*; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D006493:Heparin