title: Production of immune-modulatory nonclassical molecules HLA-G and HLA-E by tumor infiltrating ameboid microglia/macrophages in glioblastomas: a role in innate immunity?
abstract: The possible role of immune-modulatory nonclassical molecules HLA-G and HLA-E in an anti-tumoral response and development of glioblastoma is not well characterized. In this study, we evaluated an expression of HLA-G and HLA-E by activated tumor infiltrating microglia/macrophages. We found production of HLA-G and HLA-E by tumor infiltrating activated microglia/macrophages in a majority of glioblastomas. We speculate that the expression of these molecules by activated microglia/CNS macrophages plays a role in the anti-tumoral immunity in the development of glioblastoma. Mechanisms of microglia-glioblastoma cell interactions with respect to the expression of these molecules deserves further study.
authors.affiliation: Department of Pathology, University Hospital, Jihlavska 20, Brno 625 00, Czech Republic. lkren@fnbrno.cz
authors.forename: Leos
authors.initials: L
authors.lastname: Kren
authors.forename: Katarina
authors.initials: K
authors.lastname: Muckova
authors.forename: Eva
authors.initials: E
authors.lastname: Lzicarova
authors.forename: Marek
authors.initials: M
authors.lastname: Sova
authors.forename: Vaclav
authors.initials: V
authors.lastname: Vybihal
authors.forename: Tomas
authors.initials: T
authors.lastname: Svoboda
authors.forename: Pavel
authors.initials: P
authors.lastname: Fadrus
authors.forename: Martin
authors.initials: M
authors.lastname: Smrcka
authors.forename: Ondrej
authors.initials: O
authors.lastname: Slaby
authors.forename: Radek
authors.initials: R
authors.lastname: Lakomy
authors.forename: Petr
authors.initials: P
authors.lastname: Vanhara
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Krenova
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Michalek
mesh_terms: D001921:Brain / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D001932:Brain Neoplasms / Q000276:immunology* / Q000503:physiopathology; D002450:Cell Communication / Q000276:immunology; D002465:Cell Movement / Q000276:immunology; D005909:Glioblastoma / Q000276:immunology* / Q000503:physiopathology; D005911:Gliosis / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D006680:HLA Antigens / Q000378:metabolism*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology / Q000502:physiology*; D056747:Immunomodulation / Q000502:physiology; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D017628:Microglia / Q000276:immunology* / Q000378:metabolism; D000097625:HLA-E Antigens
chemical_list: D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D000097625:HLA-E Antigens