title: Intraosseous soft tissue perineurioma: report of a vertebral example.
abstract: OBJECTIVE
  To describe a unique intraosseous perineurioma affecting the L2 vertebral body and pedicle of a 28-year-old female.
  
  
  METHODS
  A lytic, expansive lesion virtually limited to bone was gross totally excised; only minimal epidural extension was noted.
  
  
  METHODS
  Histologic, immunohistochemical and ultrastructural studies were performed.
  
  
  RESULTS
  The tumor was partially encapsulated, moderately cellular, and showed classic features of benign soft tissue perineurioma, being composed of interlacing fascicles of spindle cells with undulating nuclei and long, very narrow, cytoplasmic processes. Immunohistochemistry showed reactivity for EMA, Glut-1, claudin, collagen-4 and CD34; no S-100 or neurofilament protein staining was seen to suggest an origin in nerve.
  
  
  CONCLUSIONS
  Perineurioma, a tumor affecting soft tissue, and presumably nerve-unassociated, may affect bone. No prior entirely osseous examples have been reported. This tumor expands the differential diagnosis of spindle cell tumors of bone.
authors.affiliation: Department of Pathology, Acibadem Medical Center, Istanbul, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Sav
authors.forename: B W
authors.initials: BW
authors.lastname: Scheithauer
authors.forename: W A S
authors.initials: WA
authors.lastname: Taylor
authors.forename: G
authors.initials: G
authors.lastname: Miller
authors.forename: W
authors.initials: W
authors.lastname: Stewart
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008159:Lumbar Vertebrae / Q000473:pathology* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D018317:Nerve Sheath Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor