title: Successful pregnancy by insemination of spermatozoa in a woman with a human seminal plasma allergy: should in vitro fertilization be considered first?
abstract: OBJECTIVE
  To raise the possibility that pregnancy can be obtained by assisted reproductive techniques in patients with human seminal plasma allergy.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  A woman consulted for a 3-year primary infertility. She reported lack of intercourse because of a seminal plasma allergy.
  
  
  METHODS
  One intrauterine insemination associated with antihistamine treatment was performed with carefully washed spermatozoa.
  
  
  RESULTS
  Immediately after the insemination, the patient had an allergic reaction treated by steroids. Fortunately, this single attempt led to a successful pregnancy, and the patient gave birth to a healthy girl.
  
  
  CONCLUSIONS
  Pregnancies can be obtained in patients with seminal plasma hypersensitivity by means of intrauterine insemination. However, serious complications may occur after performing intrauterine insemination, which is not a totally reliable method to prevent an allergic reaction. Thus a multidisciplinary team should follow such patients carefully and watch for the potential risks and side effects. In vitro fertilization may represent the more cautious option.
authors.affiliation: Department of Histology and Biology of Reproduction, Tenon Hospital (Assistance Publique Hôpitaux de Paris), Paris, France. c_frapsauce@yahoo.fr
authors.forename: Cynthia
authors.initials: C
authors.lastname: Frapsauce
authors.forename: Isabelle
authors.initials: I
authors.lastname: Berthaut
authors.forename: Vanina
authors.initials: V
authors.lastname: de Larouziere
authors.forename: Emmanuelle Mathieu
authors.initials: EM
authors.lastname: d'Argent
authors.forename: Jean-Eric
authors.initials: JE
authors.lastname: Autegarden
authors.forename: Hanene
authors.initials: H
authors.lastname: Elloumi
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Antoine
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Mandelbaum
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D007247:Infertility, Female / Q000209:etiology / Q000276:immunology* / Q000628:therapy*; D007315:Insemination, Artificial; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D012661:Semen / Q000276:immunology; D013094:Spermatozoa / Q000276:immunology*
chemical_list: D006633:Histamine Antagonists