title: Neutropenia induced by second generation antipsychotics: a prospective investigation.
abstract: BACKGROUND
  Clozapine is known to induce neutropenia as well as agranulocytosis. Some cases of olanzapine- and risperidone-induced neutropenia and agranulocytosis have also been reported. We prospectively investigated schizophrenia patients treated with second generation antipsychotics with respect to alterations of white blood cell counts.
  
  
  METHODS
  In an analysis of our drug monitoring program, we studied white blood cell counts in 104 patients receiving different second generation antipsychotics other than clozapine for at least six months and compared them with those of 28 patients receiving clozapine.
  
  
  RESULTS
  We found neutropenia (neutrophils <2 000/microL) in the mixed group in 17.6% and in 11.8% of patients treated with clozapine during the first 6 months. There was no statistically significant difference between those groups with respect to the risk to develop neutropenia during the investigation period. There was no case of agranulocytosis. Neutropenia was transient in all patients. Eosinophilia occurred in some patients that developed neutropenia later on but had no significant predictive value.
authors.affiliation: Medical University Innsbruck, Department of Psychiatry, Innsbruck, Austria. Maria.Rettenbacher@i-med.ac.at
authors.forename: M A
authors.initials: MA
authors.lastname: Rettenbacher
authors.forename: A
authors.initials: A
authors.lastname: Hofer
authors.forename: G
authors.initials: G
authors.lastname: Kemmler
authors.forename: W W
authors.initials: WW
authors.lastname: Fleischhacker
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003024:Clozapine / Q000009:adverse effects; D016903:Drug Monitoring; D004802:Eosinophilia / Q000097:blood / Q000139:chemically induced / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007958:Leukocyte Count; D008297:Male; D009503:Neutropenia / Q000097:blood / Q000139:chemically induced* / Q000453:epidemiology; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine