title: Quantitative 19F imaging using inductively coupled reference signal injection.
abstract: This report describes recent efforts on our continuous development of a synthetic signal injection method for quantification of metabolite content in MR spectroscopy and MRI. Previous work showed that conversion of spectral peaks to quantitative units of metabolite content could be achieved with a calibrated synthetic free induction decay generated by an inductively coupled injection coil. This work demonstrates that calibrated synthetic voxels, injected in the same manner, can be used to quantify metabolite content in real (19)F image voxels. Images of vials containing different concentrations of sodium fluoride (NaF) were converted to units of moles by reference to precalibrated synthetically injected voxels. Additional images of vials containing variable sodium chloride (NaCl) demonstrate that the quantification process is robust and immune to changes in coil loading conditions.
authors.affiliation: Department of Radiology, University of Washington, Seattle, Washington 98195, USA. dhoonlee@u.washington.edu
authors.forename: Donghoon
authors.initials: D
authors.lastname: Lee
authors.forename: Kenneth
authors.initials: K
authors.lastname: Marro
authors.forename: Eric
authors.initials: E
authors.lastname: Shankland
authors.forename: Mark
authors.initials: M
authors.lastname: Mathis
mesh_terms: D000465:Algorithms; D005461:Fluorine / Q000032:analysis*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D005461:Fluorine