title: Chrysoeriol isolated from the leaves of Eurya ciliata stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells.
abstract: Chrysoeriol (1) was isolated as the main constituent from the methanol extract of the dried leaves of Eurya ciliata Merr. To investigate the bioactivities of 1 on bone metabolism, its effects on the function of osteoblastic MC3T3-E1 cells were studied. Compound 1 significantly increased the growth of MC3T3-E1 cells and caused a significant elevation of alkaline phosphatase activity, collagen content, and nodule mineralization in the cells (P < 0.05). Our data indicate that the enhancement of osteoblast function by 1 may be useful in the prevention of osteoporosis.
authors.affiliation: Chungnam National University, Daejeon, South Korea.
authors.forename: Bui Huu
authors.initials: BH
authors.lastname: Tai
authors.forename: Nguyen Manh
authors.initials: NM
authors.lastname: Cuong
authors.forename: Tran Thu
authors.initials: TT
authors.lastname: Huong
authors.forename: Eun-Mi
authors.initials: EM
authors.lastname: Choi
authors.forename: Jeong-Ah
authors.initials: JA
authors.lastname: Kim
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation; D029791:Ericaceae / Q000737:chemistry*; D047309:Flavones; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D010006:Osteoblasts / Q000187:drug effects / Q000378:metabolism*; D018515:Plant Leaves / Q000737:chemistry; D014744:Vietnam
chemical_list: D047309:Flavones; D005419:Flavonoids; D000469:Alkaline Phosphatase; C007054:chrysoeriol