title: Fatal disseminated mucormycosis in a patient with mantle cell non-Hodgkin's lymphoma: an autopsy case.
abstract: A patient with mantle cell non-Hodgkin's lymphoma presented herself with fever, nausea, right upper quadrant pain on the 7th day of R-CHOP chemotherapy. After hospitalization with the suspicion of acute cholecystitis, she received antibiotherapy with G-CSF because of emerging neutropenia at the 10th day of chemotherapy. Abdominal computed tomography revealed small infarcts in the spleen and kidneys. The ecchymotic lesion which developed on her right lateral malleolus, became bullous in the following days and treated as ecthyma gangrenosum. Although the patient was afebrile with a normal neutrophil count on the third day of antibiotherapy, she developed acute renal failure and deteriorated rapidly. The patient underwent hemodialysis but expired on the 10th day of hospitalization. Post mortem autopsy findings showed ischemic infarction and necrosis of parenchyma due to mycotic thrombosis of arteries and veins of many organs (heart, lung, diaphragm, kidneys, spleen, gut mucosa) as well as invasion of vessel walls and parenchyma by mucor. We reviewed mucormycosis in the light of this case.
authors.affiliation: Deparment of Hematology, Faculty of Medicine, Dokuz Eylul University. inci074@yahoo.com
authors.forename: Inci
authors.initials: I
authors.lastname: Alacacioglu
authors.forename: Aydanur
authors.initials: A
authors.lastname: Kargi
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Ozcan
authors.forename: Ozden
authors.initials: O
authors.lastname: Piskin
authors.forename: Cilem
authors.initials: C
authors.lastname: Solak
authors.forename: Mustafa
authors.initials: M
authors.lastname: Secil
authors.forename: Mehtat
authors.initials: M
authors.lastname: Unlu
authors.forename: Fatih
authors.initials: F
authors.lastname: Demirkan
authors.forename: Guner Hayri
authors.initials: GH
authors.lastname: Ozsan
authors.forename: Bulent
authors.initials: B
authors.lastname: Undar
mesh_terms: D001344:Autopsy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D020522:Lymphoma, Mantle-Cell / Q000150:complications / Q000473:pathology*; D008875:Middle Aged; D009091:Mucormycosis / Q000150:complications / Q000473:pathology*