title: Discovery of a new series of 5-HT1A receptor agonists.
abstract: Starting from compounds previously identified as alpha(1)-adrenoceptor antagonists that were also found to bind to the 5-HT(1A) receptor, in an attempt to separate the two activities, a new series of 5-HT(1A) receptor agonists was identified and shown to have high potency and/or high selectivity. Of these, compound 13, which combines high selectivity (5-HT(1A)/alpha(1)=151) and good agonist potency (pD(2)=7.82; E(max)=76), was found to be the most interesting.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università degli Studi di Modena e Reggio Emilia, Modena, Italy.
authors.forename: Silvia
authors.initials: S
authors.lastname: Franchini
authors.forename: Adolfo
authors.initials: A
authors.lastname: Prandi
authors.forename: Claudia
authors.initials: C
authors.lastname: Sorbi
authors.forename: Annalisa
authors.initials: A
authors.lastname: Tait
authors.forename: Annamaria
authors.initials: A
authors.lastname: Baraldi
authors.forename: Piero
authors.initials: P
authors.lastname: Angeli
authors.forename: Michela
authors.initials: M
authors.lastname: Buccioni
authors.forename: Antonio
authors.initials: A
authors.lastname: Cilia
authors.forename: Elena
authors.initials: E
authors.lastname: Poggesi
authors.forename: Paola
authors.initials: P
authors.lastname: Fossa
authors.forename: Livio
authors.initials: L
authors.lastname: Brasili
mesh_terms: D055808:Drug Discovery; D058825:Serotonin 5-HT1 Receptor Agonists
chemical_list: D058825:Serotonin 5-HT1 Receptor Agonists