title: Oxidative stress in the liver of mice caused by intraperitoneal injection with lanthanoides.
abstract: In order to study the mechanisms underlying the effects of lanthanoid (Ln) on the liver, ICR mice were injected with LaCl₃, CeCl₃, and NdCl₃ at a dose of 20 mg/kg BW into the abdominal cavity daily for 14 days. We then examined oxidative stress-mediated responses in the liver. The increase of lipid peroxide in the liver produced by Ln suggested an oxidative attack that was activated by a reduction of antioxidative defense mechanisms as measured by analyzing the activities of superoxide dismutase, catalase, and ascorbate peroxidase, as well as antioxidant levels such as glutathione and ascorbic acid, which were greatest in Ce(3+) treatment, medium in Nd(3+), and least in La(3+). Our results also implied that the oxidative stress in the liver caused by Ln likely is Ce(3+) > Nd(3+) >La(3+), but the mechanisms need to be further studied in future.
authors.affiliation: Medical College of Soochow University, Suzhou 215123, People's Republic of China.
authors.forename: Min
authors.initials: M
authors.lastname: Fei
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Yuguan
authors.initials: Y
authors.lastname: Ze
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Gong
authors.forename: Yanmei
authors.initials: Y
authors.lastname: Duan
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Zhao
authors.forename: Han
authors.initials: H
authors.lastname: Wang
authors.forename: Fashui
authors.initials: F
authors.lastname: Hong
mesh_terms: D000818:Animals; D007274:Injections, Intraperitoneal; D028581:Lanthanoid Series Elements / Q000008:administration & dosage / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D028581:Lanthanoid Series Elements; D017382:Reactive Oxygen Species