Incidental Lewy body disease: clinical comparison to a control cohort.
Limited clinical information has been published on cases pathologically diagnosed with incidental Lewy body disease (ILBD). Standardized, longitudinal movement and cognitive data was collected on a cohort of subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program. Of 277 autopsied subjects who had antemortem clinical evaluations within the previous 3 years, 76 did not have Parkinson's disease, a related disorder, or dementia of which 15 (20%) had ILBD. Minor extrapyramidal signs were common in subjects with and without ILBD. Cognitive testing revealed an abnormality in the ILBD group in the Trails B test only. ILBD cases had olfactory dysfunction; however, sample size was very small. This preliminary report revealed ILBD cases have movement and cognitive findings that for the most part were not out of proportion to similarly assessed and age-similar cases without Lewy bodies. Larger sample size is needed to have the power to better assess group differences.
Adler
Charles H
CH
Parkinson's Disease and Movement Disorders Center, Mayo Clinic, Scottsdale, Arizona 85259, USA. cadler@mayo.edu
Connor
Donald J
DJ
Hentz
Joseph G
JG
Sabbagh
Marwan N
MN
Caviness
John N
JN
Shill
Holly A
HA
Noble
Brie
B
Beach
Thomas G
TG
D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D009483:Neuropsychological Tests; D000857:Olfaction Disorders / Q000175:diagnosis; D010300:Parkinson Disease / Q000175:diagnosis* / Q000503:physiopathology; D012189:Retrospective Studies; D012720:Severity of Illness Index