Analgesic and anti-inflammatory effects of aqueous extract of Zea mays husk in male Wistar rats.
The analgesic and anti-inflammatory activities of Zea mays husk extract (25, 50, 100, and 200 mg/kg of body weight) were investigated in rats. The hot plate and formalin-induced paw licking models were used to assess analgesic effects of the extract, whereas the carrageenan and cotton pellet models were used for the evaluation of anti-inflammatory activity. The extract at 25, 50, 100, and 200 mg/kg body weight significantly (P < .05) reduced pain stimuli and inflammatory activity when compared with the control group. The reductions in paw licking time and granuloma weight in the formalin and cotton pellet models were both dose dependent. Also, the 200 mg/kg doses of the extract produced higher effects compared with indomethacin (5 mg/kg body of weight) in all the tests. These observations suggest that Z. mays husk extract may have analgesic and anti-inflammatory effects that may be due to its tannins and polyphenolic constituents. These results provide scientific validation for the use of Z. mays husk decoction for the treatment of pain and inflammatory conditions in Nigerian folk medicine.
Owoyele
Bamidele V
BV
Department of Physiology, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Nigeria. deleyele@yahoo.com
Negedu
Muhammed N
MN
Olaniran
Samuel O
SO
Onasanwo
Samuel A
SA
Oguntoye
Stephen O
SO
Sanya
Joseph O
JO
Oyeleke
Sabitiu A
SA
Ibidapo
Adekemi J
AJ
Soladoye
Ayodele O
AO
D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use; D006099:Granuloma / Q000188:drug therapy; D007213:Indomethacin / Q000494:pharmacology / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D016488:Medicine, African Traditional; D010146:Pain / Q000188:drug therapy*; D010636:Phenols / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D059808:Polyphenols; D051381:Rats; D017208:Rats, Wistar; D013634:Tannins / Q000494:pharmacology / Q000627:therapeutic use; D003313:Zea mays
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D013634:Tannins; D007213:Indomethacin