title: [Cyanoacrylate adhesives for the synthesis of soft tissue].
abstract: BACKGROUND
  Tissue adhesives have been used for the synthesis of wound due to their painless application and quick and easy handling.
  
  
  OBJECTIVE
  The purpose of this study was to analyze and compare the compatibility of the adhesives ethylcyanoacrylate (Super Bonder) and butyl-cyanoacrylate (Histoacryl), and to compare the reparation of incisions in the dorsum of rats with suture and the respective adhesives.
  
  
  METHODS
  Fifteen rats were used. Two surgical pockets were created in their dorsum. A polyethylene tube (10mm x 1mm) was implanted in each one. Each tube was filled with the adhesives Super Bonder(left side) and Histoacryl (right side). The incisions on the left side were closed with Super Bonder, and the incisions on the right side, with Histoacryl. A median incision between the two other incisions was made and closed with braided silk suture. The animals were killed after, 7, 35 and 120 days.
  
  
  RESULTS
  The adhesives used in the present study did not promote inflammatory reaction when used for the synthesis of incisions. However, when implanted subcutaneously, they caused an inflammatory reaction within 120 days. Reaction is more severe with Histoacryl.
  
  
  CONCLUSIONS
  Super Bonder and Histoacryl can be used effectively in the healing of incised tissues; they aid in the suture of incisions. However, these adhesives can be used for the synthesis of wounds, lacerations or cutaneous incisions.
authors.affiliation: Instituto de Química de Araraquara, Universidade Estadual Paulista, São Paulo, SP, Brasil. sybele_saska@yahoo.com.br
authors.forename: Sybele
authors.initials: S
authors.lastname: Saska
authors.forename: Ana Maria Minarelli
authors.initials: AM
authors.lastname: Gaspar
authors.forename: Eduardo
authors.initials: E
authors.lastname: Hochuli-Vieira
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D003487:Cyanoacrylates; D004659:Enbucrilate; D008297:Male; D008422:Materials Testing; D051381:Rats; D017207:Rats, Sprague-Dawley; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D003487:Cyanoacrylates; C538957:Super Bonder Instant Adhesive; D004659:Enbucrilate