Anticlastogenic effect of apigenin in human lymphocytes treated with ethinylestradiol.
In the present study the antigenotoxic effect of apigenin was studied against a genotoxic dose of ethinylestradiol using the damage parameters of chromosomal aberrations (CAs), sister chromatid exchanges (SCEs) and cell cycle kinetics (CCK). Human peripheral blood lymphocytes were cultured and treated with 10 microM of ethinylestradiol along with doses of 5, 10, 15 and 20 microM of apigenin. A clear decrease in the genotoxic damage induced by ethinylestradiol was observed with increasing doses of apigenin, suggesting a protective role for apigenin during ethinylestradiol therapy.
Siddique
Yasir Hasan
YH
Human Genetics and Toxicology Lab, Section of Genetics, Department of Zoology, Faculty of Life Sciences, Aligarh Muslim University, Aligarh, UP 202002, India. yasir_hasansiddique@rediffmail.com
Ara
Gulshan
G
Beg
Tanveer
T
Afzal
Mohammad
M
D000328:Adult; D047310:Apigenin / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D002869:Chromosome Aberrations / Q000139:chemically induced / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004997:Ethinyl Estradiol / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D009153:Mutagens / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects; D055815:Young Adult
D009153:Mutagens; D004997:Ethinyl Estradiol; D047310:Apigenin