title: Dermabrasion for acne scars during treatment with oral isotretinoin.
abstract: BACKGROUND
  Oral isotretinoin is the criterion standard treatment for severe inflammatory acne associated with scar development. Atypical or exaggerated cicatrization related to oral isotretinoin was reported throughout the 1980s and 1990s. Dermabrasion for atrophic acne scar revision is not recommended 6 to 12 months from the end of oral isotretinoin treatment.
  
  
  OBJECTIVE
  To evaluate wound healing after localized dermabrasion in patients receiving oral isotretinoin.
  
  
  METHODS
  Interventional, prospective study involving seven patients taking oral isotretinoin to treat acne and with atrophic acne scars on the face. Manual dermabrasion was performed on all patients in an area of approximately 1 cm(2), and a 6-month reepithelization follow-up by clinical evaluation was conducted.
  
  
  RESULTS
  All patients presented normal cicatrization evolution; hypertrophic scarring or keloid as a result of localized abrasion was not observed, and atrophic acne scar revision result was excellent.
  
  
  CONCLUSIONS
  The current recommendation to wait 6 to 12 months after treatment with oral isotretinoin for acne scar revision using dermabrasion should be re-evaluated. Abrasion of a small test area may be a useful predictor of wound healing, enabling earlier acne scar treatment using this procedure.
authors.affiliation: Department of Dermatology, Hospital São Paulo, Brazil. edileia_bagatin@yahoo.com.br
authors.forename: Ediléia
authors.initials: E
authors.lastname: Bagatin
authors.forename: Lilia Ramos
authors.initials: LR
authors.lastname: dos Santos Guadanhim
authors.forename: Samira
authors.initials: S
authors.lastname: Yarak
authors.forename: Cristhine Souza Leão
authors.initials: CS
authors.lastname: Kamamoto
authors.forename: Fernando Augusto
authors.initials: FA
authors.lastname: de Almeida
mesh_terms: D000153:Acne Keloid / Q000209:etiology / Q000601:surgery; D000152:Acne Vulgaris / Q000150:complications* / Q000188:drug therapy*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D017439:Cicatrix, Hypertrophic / Q000209:etiology / Q000601:surgery*; D003131:Combined Modality Therapy; D003869:Dermabrasion / Q000379:methods*; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005145:Face; D005260:Female; D006801:Humans; D015474:Isotretinoin / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D017060:Patient Satisfaction; D011446:Prospective Studies; D016896:Treatment Outcome; D014945:Wound Healing; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; D015474:Isotretinoin