title: Acute lung injury with alveolar hemorrhage due to a novel swine-origin influenza A (H1N1) virus.
abstract: A 40-year-old woman with no major medical illness except for morbid obesity (BMI 40.7) was admitted to our hospital because of bilateral pneumonia due to a novel swine-origin influenza A (H1N1) virus (S-OIV). Non-invasive ventilation was introduced because of the hypoxemia. The description of bronchoalveolar lavage fluid findings showed an alveolar hemorrhage and neutrophilic inflammation. No evidence of bacterial infection was found. She was treated with oseltamivir and sivelestat sodium, neutrophil elastase inhibitor and thereafter was successfully discharged from the hospital. This case is the first report of a patient with acute lung injury with an alveolar hemorrhage caused by the S-OIV.
authors.affiliation: The First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto.
authors.forename: Toshiki
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Kenji
authors.initials: K
authors.lastname: Tsushima
authors.forename: Atsuhito
authors.initials: A
authors.lastname: Ushiki
authors.forename: Nobumitsu
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Urushihata
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Koizumi
authors.forename: Keishi
authors.initials: K
authors.lastname: Kubo
mesh_terms: D055371:Acute Lung Injury / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology*; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives / Q000627:therapeutic use; D006470:Hemorrhage / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000472:pathogenicity*; D007251:Influenza, Human / Q000150:complications / Q000188:drug therapy; D008171:Lung Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology*; D053139:Oseltamivir / Q000627:therapeutic use; D013449:Sulfonamides / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D013449:Sulfonamides; D053139:Oseltamivir; C069195:sivelestat; D005998:Glycine