The PI3K/Akt pathway may play a key role in social isolation-caused schizophrenia comment re: Increased dopamine D2(High) receptors in rats reared in social isolation.
Chen
Jiezhong
J
Huang
Xu-Feng
XF
D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000503:physiopathology; D002454:Cell Differentiation / Q000502:physiology; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D004789:Enzyme Activation / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D051381:Rats; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D012559:Schizophrenia / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology; D012934:Social Isolation / Q000523:psychology*
D017448:Receptors, Dopamine D2; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D004298:Dopamine