title: Recombinant human bone morphogenetic protein 2-induced heterotopic ossification of the retroperitoneum, psoas muscle, pelvis and abdominal wall following lumbar spinal fusion.
abstract: A 45-year-old man presented with vertebral collapse at L5 as an initial manifestation of multiple myeloma and underwent spinal fusion surgery using recombinant human bone morphogenetic protein-2 (rhBMP-2). Subsequent computed tomography (CT) scans and X-rays revealed heterotopic ossification of the left psoas muscle, pelvis, and anterior abdominal wall. While the occurrence of heterotopic ossification has previously been reported when rhBMP-2 has been used for spinal fusion surgery, this case demonstrates that it can occur to a much greater degree than previously seen.
authors.affiliation: The George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037, USA. rajshah@gwmail.gwu.edu
authors.forename: Raj K
authors.initials: RK
authors.lastname: Shah
authors.forename: Valeria M
authors.initials: VM
authors.lastname: Moncayo
authors.forename: Robert D
authors.initials: RD
authors.lastname: Smitson
authors.forename: Claude
authors.initials: C
authors.lastname: Pierre-Jerome
authors.forename: Michael R
authors.initials: MR
authors.lastname: Terk
mesh_terms: D034861:Abdominal Wall; D055396:Bone Morphogenetic Protein 2 / Q000009:adverse effects* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D009999:Ossification, Heterotopic / Q000139:chemically induced* / Q000000981:diagnostic imaging; D010388:Pelvis / Q000000981:diagnostic imaging*; D011860:Radiography, Abdominal; D011994:Recombinant Proteins / Q000009:adverse effects*; D013123:Spinal Fusion / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D011994:Recombinant Proteins