[Analysis of clinical features of community-acquired pneumonia caused by pediatric respiratory syncytial virus and human metapneumovirus].
We retrospectively reviewed the background, clinical features, blood tests, and complications in the 720 children seen for acute respiratory tract infection from July 2004 to December 2005. Of these, 75 (10.5%) were diagnosed with pneumonia due to respiratory syncytial virus (RSV) and 19 (2.6%) with pneumonia due to human metapneumovirus (hMPV) based on multiplex PCR analysis of nasopharyngeal samples. RSV was PCR-positive mostly in winter, -from November to January-, and hMPV mostly in spring, -from March to June. The mean RSV pneumonia group age was 1.3 +/- 1.4 years and in the hMPV pneumonia group 3.0 +/- 3.1 years, showing a statistically significant differences in the age of virus onset. Clinically the RSV group showed more rhinorrhea and wheezing (p < 0.05) and the hMPV group a higher maximum body temperature and a longer wheezing duration (p < 0.05). Fever, cough, vomiting, diarrhea, fever frequency, and C-reactive protein level were similar in both groups (p > 0.05). Complication prevalence was 49.3% in the RSV group and 42.1% in the hMPV group. Acute otitis media was seen more often in the RSV group (32.0%) and febrile convulsion more often in the hMPV group (15.8%) (p > 0.05). These findings may be helpful in clinically diagnosing community-acquired pneumonia due to RSV or hMPV.
Okada
Takafumi
T
Department of Pediatrics, National Hospital Organization Tokyo Medical Center.
Matsubara
Keita
K
Matsushima
Takahiro
T
Komiyama
Osamu
O
Chiba
Nahoko
N
Hamano
Keiko
K
Morozumi
Miyuki
M
Ubukata
Kimiko
K
Sunakawa
Keisuke
K
Iwata
Satoshi
S
D000367:Age Factors; D017714:Community-Acquired Infections / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D029121:Metapneumovirus; D018184:Paramyxoviridae Infections / Q000453:epidemiology; D011024:Pneumonia, Viral / Q000453:epidemiology; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology; D012189:Retrospective Studies; D014041:Tokyo / Q000453:epidemiology