title: Frontotemporal dementia and pharmacologic interventions.
abstract: Frontotemporal lobar degeneration is comprised of three syndromes: frontotemporal dementia (FTD), semantic dementia, and progressive nonfluent aphasia, with FTD being the most prevalent. FTD is characterized predominantly by character change and disordered social conduct. A variety of pathologies may underlie these syndromes, yet it is the location of the pathology rather than the type that dictates the clinical features of the disease. Several medications have been investigated to measure efficacy of treatment in FTD, often with mixed results. The authors review these findings and comment on future directions.
authors.affiliation: Baycrest, Kunin-Lunenfeld Applied Research Unit, Toronto, Ontario, Canada. tkaye@klaru-baycrest.on.ca
authors.forename: Edward D
authors.initials: ED
authors.lastname: Kaye
authors.forename: Ana
authors.initials: A
authors.lastname: Petrovic-Poljak
authors.forename: Nicolaas P L G
authors.initials: NP
authors.lastname: Verhoeff
authors.forename: Morris
authors.initials: M
authors.lastname: Freedman
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D001921:Brain / Q000201:enzymology; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use*; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D057180:Frontotemporal Dementia / Q000188:drug therapy* / Q000201:enzymology; D005702:Galantamine / Q000627:therapeutic use*; D006801:Humans; D001523:Mental Disorders / Q000188:drug therapy / Q000453:epidemiology / Q000523:psychology; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D048448:Phenylcarbamates / Q000627:therapeutic use*; D011985:Receptors, Serotonin / Q000378:metabolism; D000068836:Rivastigmine; D012642:Selegiline / Q000627:therapeutic use*
chemical_list: D000928:Antidepressive Agents; D002800:Cholinesterase Inhibitors; D018696:Neuroprotective Agents; D048448:Phenylcarbamates; D011985:Receptors, Serotonin; D005702:Galantamine; D012642:Selegiline; D002795:Choline O-Acetyltransferase; D000068836:Rivastigmine; D004298:Dopamine