title: The effect of injectable butaphosphan and cyanocobalamin on postpartum serum beta-hydroxybutyrate, calcium, and phosphorus concentrations in dairy cattle.
abstract: The objective of this study was to determine the effect of an injection of 10% butaphosphan and cyanocobalamin (Catosal, Bayer, Shawnee Mission, KS) on the day of calving and 1 d later on the prevalence of subclinical ketosis in dairy cattle in the early postpartum period. Cows from 4 herds (n=1,122) were randomized to receive either 25mL of 10% butaphosphan and cyanocobalamin or 25mL of sterile water subcutaneously on both days. Each milliliter of Catosal contained 0.05mg of cyanocobalamin and 100mg of butaphosphan, which provided 17.3mg of P in the form of [1-(butylamino)-1-methylethyl]-phosphonic acid. Serum was sampled for beta-hydroxybutyrate (BHBA) concentration at calving (pretreatment) and again between 3 and 10 d in milk. A subset of samples from mature cows was also evaluated for serum Ca and P concentrations. When cows from all age groups were included in the analysis, there was no difference between the median serum BHBA concentrations of cows in the 2 treatment groups, and no difference in the proportion of hyperketonemic cows (serum BHBA >or=1,200micromol/L) during the first week postpartum. When the analysis was restricted to mature cows (lactation >or=3), both the median BHBA concentration and the proportion of hyperketonemic cows were significantly lower in the treatment group than in the placebo group. Serum Ca and P concentrations did not differ between treatment groups. Our results suggest that injection of butaphosphan and cyanocobalamin on the day of calving and 1 d later may decrease the prevalence of subclinical ketosis during the week after calving in mature dairy cows, but not in first- and second-lactation animals.
authors.affiliation: Department of Population Health, University of Georgia, Athens 30602, USA.
authors.forename: E
authors.initials: E
authors.lastname: Rollin
authors.forename: R D
authors.initials: RD
authors.lastname: Berghaus
authors.forename: P
authors.initials: P
authors.lastname: Rapnicki
authors.forename: S M
authors.initials: SM
authors.lastname: Godden
authors.forename: M W
authors.initials: MW
authors.lastname: Overton
mesh_terms: D020155:3-Hydroxybutyric Acid / Q000097:blood*; D000818:Animals; D002118:Calcium / Q000097:blood*; D002417:Cattle; D002418:Cattle Diseases / Q000453:epidemiology / Q000517:prevention & control*; D003612:Dairying; D005260:Female; D007662:Ketosis / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary*; D016015:Logistic Models; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000008:administration & dosage*; D010758:Phosphorus / Q000097:blood*; D049590:Postpartum Period; D011247:Pregnancy; D015995:Prevalence; D011897:Random Allocation
chemical_list: D063065:Organophosphonates; D009943:Organophosphorus Compounds; D010758:Phosphorus; C030504:butaphosphone; D002118:Calcium; D020155:3-Hydroxybutyric Acid