title: Synthesis of pyrrolo[1,3]diazepines by a dipolar cycloaddition - retro-Mannich domino reaction.
abstract: Microwave irradiation facilitated the synthesis of 4-arylthio-3-oxazolin-5-ones from ethyl cyanoformate, thiophenol, and cyclic ketones. Subsequent decarboxylation and in situ [3+2] cycloaddition provided novel 2,3,4,5-tetrahydro-1H-pyrrolo[1,2-c][1,3]diazepine scaffolds after a spontaneous retro-Mannich domino reaction.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
authors.forename: Mary
authors.initials: M
authors.lastname: Liang
authors.forename: Cecilia
authors.initials: C
authors.lastname: Saiz
authors.forename: Chiara
authors.initials: C
authors.lastname: Pizzo
authors.forename: Peter
authors.initials: P
authors.lastname: Wipf