3-Substituted pyrazinone nucleosides--a new family of D4T analogues.
The synthesis of a new family of D4T analogues is described to study the influence of pyrazinone base on antiretroviral power. Substitution of 3H by methyl or n-decyl increases the lipophilic character and may facilitate diffusion across cell membranes. The compounds were characterized by (1)H NMR and infrared spectroscopy. Antiviral (HIV-1) properties of these compounds were examined.
Batoux
Nathalie
N
Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques, Universite de Limoges, Limoges, France.
Granet
Robert
R
Zerrouki
Rachida
R
Krausz
Pierre
P
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D011719:Pyrazines / Q000737:chemistry*; D018119:Stavudine / Q000737:chemistry*
D019380:Anti-HIV Agents; D009705:Nucleosides; D011719:Pyrazines; D018119:Stavudine