title: A hepatitis B virus inhibitory neolignan from Herpetospermum caudigerum.
abstract: A new dihydrobenzofuran neolignan, herpepropenal, was isolated from the seeds of Herpetospermum caudigerum. Its chemical structure was established based on spectroscopic analysis. In this work, the inhibitory effects of herpepropenal on hepatitis B virus DNA and on the replication and expression of hepatitis B surface antigen and hepatitis B e antigen were also evaluated. The new compound exhibited inhibitory effects against hepatitis B virus.
authors.affiliation: Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, P. R. China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Hong-Jun
authors.initials: HJ
authors.lastname: Zhang
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Zhang
authors.forename: Wan-Sheng
authors.initials: WS
authors.lastname: Chen
authors.forename: Hai-Long
authors.initials: HL
authors.lastname: Yuan
authors.forename: Hou-Wen
authors.initials: HW
authors.lastname: Lin
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D019662:Cucurbitaceae / Q000737:chemistry*; D004279:DNA, Viral / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006514:Hepatitis B Surface Antigens / Q000378:metabolism; D006568:Herpesvirus 1, Cercopithecine / Q000187:drug effects*; D006801:Humans; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D012639:Seeds / Q000737:chemistry*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D017705:Lignans; C549744:herpepropenal