title: Elevation of homocysteine levels is only partially reversed after therapy in females with eating disorders.
abstract: Recent studies have shown elevated homocysteine levels in patients with eating disorders. In a prospective, longitudinal study, we investigated differences of homocysteine plasma levels in patients with anorexia nervosa (N = 12) and bulimia nervosa (N = 17) compared to healthy controls (N = 20) and alteration of homocysteine levels in patients during specific in-patient treatment. We found significantly elevated homocysteine levels in both patient groups (anorexia nervosa and bulimia nervosa) and a non-significant decrease of homocysteine during the 12-week treatment period. Furthermore, we found a significant association between low homocysteine levels and cognitive deficits, pointing toward a beneficial effect of elevated homocysteine levels on cognition in this patient group. We suppose that during effective treatment with significant increase of the body mass index, the observed hyperhomocysteinemia in patients with eating disorders is partially reversible. These findings add further evidence to the hypothesis that homocysteine might be involved in the pathophysiology of anorexia and bulimia nervosa.
authors.affiliation: Department of Psychiatry and Psychotherapy, University Hospital Erlangen, Erlangen, Germany.
authors.forename: Julia
authors.initials: J
authors.lastname: Wilhelm
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Müller
authors.forename: Martina
authors.initials: M
authors.lastname: de Zwaan
authors.forename: Julia
authors.initials: J
authors.lastname: Fischer
authors.forename: Thomas
authors.initials: T
authors.lastname: Hillemacher
authors.forename: Johannes
authors.initials: J
authors.lastname: Kornhuber
authors.forename: Stefan
authors.initials: S
authors.lastname: Bleich
authors.forename: Helge
authors.initials: H
authors.lastname: Frieling
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000097:blood* / Q000628:therapy*; D015992:Body Mass Index; D052018:Bulimia Nervosa / Q000097:blood* / Q000628:therapy*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000097:blood; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D007297:Inpatients; D009483:Neuropsychological Tests; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D006710:Homocysteine