title: Quantitative trait loci for leg weakness traits in a Landrace purebred population.
abstract: Leg weakness in pigs is a serious problem in the pig industry. We performed a whole genome quantitative trait locus (QTL) analysis to find QTLs affecting leg weakness traits in the Landrace population. Half-sib progeny (n = 522) with five sires were measured for leg weakness traits. Whole genome QTL mapping was performed using a half-sib regression-based method using 190 microsatellite markers. No experiment-wide significant QTLs affecting leg weakness traits were detected. However, at the 5% chromosome-wide level, QTLs affecting leg weakness traits were detected on chromosomes 1, 3, 10 and 11 with QTL effects ranging from 0.07 to 0.11 of the phenotypic variance. At the 1% chromosome-wide level, QTLs affecting rear feet score and total leg score were detected on chromosomes 2 and 3 with QTL effects of 0.11 and 0.13 of the phenotypic variance, respectively. On chromosome 3 and 10, some QTLs found in this study were located at nearby positions. The present study is one of the first reports of QTLs affecting fitness related traits such as leg weakness traits, that segregate within the Landrace population. The study also provides useful information for studying QTLs in purebred populations.
authors.affiliation: National Livestock Breeding Center, Odakura, Nishigo, Fukushima, Japan. y0uemoto@nlbc.go.jp
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Uemoto
authors.forename: Shuji
authors.initials: S
authors.lastname: Sato
authors.forename: Chika
authors.initials: C
authors.lastname: Ohnishi
authors.forename: Kensuke
authors.initials: K
authors.lastname: Hirose
authors.forename: Kenji
authors.initials: K
authors.lastname: Kameyama
authors.forename: Kazuo
authors.initials: K
authors.lastname: Fukawa
authors.forename: Osamu
authors.initials: O
authors.lastname: Kudo
authors.forename: Eiji
authors.initials: E
authors.lastname: Kobayashi
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D001947:Breeding; D002875:Chromosomes; D005552:Forelimb / Q000378:metabolism* / Q000503:physiopathology; D020022:Genetic Predisposition to Disease; D006614:Hindlimb / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D018895:Microsatellite Repeats; D010641:Phenotype; D040641:Quantitative Trait Loci; D034421:Sus scrofa / Q000502:physiology*; D013553:Swine Diseases / Q000235:genetics*