title: Guggullipid derivatives: synthesis and applications.
abstract: Two guggullipid derivatives, Z-guggulsulfate [4,17(20)-pregnadiene-3-one-16beta-sulfate] sodium salt and Z-guggullaurate [4,17(20)-pregnadiene-3-one-16beta-laurate], have been synthesized and evaluated for liposomal drug delivery system. Its precursor, Z-guggulsterol [4,17(20)-pregnadiene-3-one-16beta-ol], is also synthesized in gram scale starting from guggulsterone using the novel combination of known reactions in fewer steps and with higher yield than previously reported synthesis. These new synthetic guggullipid derivatives were also used in the preparation of liposomes. This new class of lipid molecules will be a useful tool in the development of nanosomal or liposomal drug delivery system.
authors.affiliation: Jina Pharmaceuticals Inc., 28100 N. Ashley Circle, Libertyville, IL 60048, USA.
authors.forename: Moghis U
authors.initials: MU
authors.lastname: Ahmad
authors.forename: Shoukath M
authors.initials: SM
authors.lastname: Ali
authors.forename: Ateeq
authors.initials: A
authors.lastname: Ahmad
authors.forename: Saifuddin
authors.initials: S
authors.lastname: Sheikh
authors.forename: Imran
authors.initials: I
authors.lastname: Ahmad
mesh_terms: D029744:Commiphora; D004337:Drug Carriers / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D010936:Plant Extracts / Q000032:analysis / Q000138:chemical synthesis*; D053149:Plant Gums / Q000032:analysis / Q000138:chemical synthesis*
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D010936:Plant Extracts; D053149:Plant Gums; C018562:guggulu extract