No Ljungan virus RNA in stool samples from the Norwegian environmental triggers of type 1 diabetes (MIDIA) cohort study.
OBJECTIVE
Ljungan virus (LjV) has been proposed as a potential environmental factor for type 1 diabetes. The objective was to test for any association of LjV with type 1 diabetes.


METHODS
A nested case-control design was used to test for any association between the development of pre-diabetic autoimmunity and presence of LjV in stool samples (n = 3,803) in the Norwegian Environmental Triggers of Type 1 Diabetes (MIDIA) study. The children followed were 27 infants who developed pre-diabetic autoimmunity during or shortly after the sampling period, 54 matched control subjects, and 94 other children.


RESULTS
No LjV RNA was detected.


CONCLUSIONS
The results indicate that LjV is rare in young children. LjV does not seem to be involved in the development of human type 1 diabetes.
Tapia
German
G
Norwegian Institute of Public Health, Oslo, Norway. german.tapia@fhi.no
Cinek
Ondrej
O
Rasmussen
Trond
T
Grinde
Bjørn
B
Rønningen
Kjersti S
KS
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000276:immunology* / Q000821:virology*; D004777:Environment; D005243:Feces / Q000821:virology; D005260:Female; D006801:Humans; D008297:Male; D009664:Norway / Q000453:epidemiology; D030061:Parechovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D010850:Picornaviridae Infections / Q000150:complications* / Q000453:epidemiology / Q000276:immunology*; D011236:Prediabetic State / Q000453:epidemiology / Q000276:immunology / Q000821:virology; D012367:RNA, Viral / Q000235:genetics; D012307:Risk Factors; D055815:Young Adult
D012367:RNA, Viral