Triterpenoids from Calophyllum inophyllum and their growth inhibitory effects on human leukemia HL-60 cells.
A new friedelane-type triterpene (1), along with seven known triterpenoids, was isolated from the stems and leaves of Calophyllum inophyllum Linn. Their structures were established as 3beta, 23-epoxy-friedelan-28-oic acid (1), friedelin (2), epifriedelanol (3), canophyllal (4), canophyllol (5), canophyllic acid (6), 3-oxo-friedelan-28-oic acid (7), and oleanolic acid (8) by spectroscopic methods (NMR, EI-MS). The growth inhibitory effects of these triterpenoids on human leukemia HL-60 cells were determined.
Li
Yan-Zhi
YZ
Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
Li
Zhan-Lin
ZL
Yin
Shi-Liang
SL
Shi
Guang
G
Liu
Ming-Sheng
MS
Jing
Yong-Kui
YK
Hua
Hui-Ming
HM
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D029759:Calophyllum / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
C553624:3beta,23-epoxy-friedelan-28-oic acid; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes