The velo-cardio-facial syndrome: the spectrum of psychiatric problems and cognitive deterioration at adult age.
The velo-cardio-facial syndrome: the spectrum of psychiatric problems and cognitive deterioration at adult age: Deletion 22q11.2 syndrome, or the velo-cardio-facial syndrome (VCFS), is a syndrome with a known but varied clinical and behavioral phenotype. We report 7 patients with 22q11.2 deletion syndrome and an intellectual disability. Aside from the described behavioral phenotype in literature, a moderate, severe or profound intellectual disability may be present. Special attention should be given to cognitive deterioration.
Evers
L J M
LJ
Koraal Group, MFCG, Multi-Disciplinary Centre for Dual Disabilities, Heel, The Netherlands. revers@stanna.koraalgroep.nl
De Die-Smulders
C E M
CE
Smeets
E E J
EE
Clerkx
M G M
MG
Curfs
L M G
LM
D000328:Adult; D001321:Autistic Disorder / Q000209:etiology; D003704:Dementia / Q000209:etiology; D004062:DiGeorge Syndrome / Q000523:psychology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000209:etiology*; D007360:Intelligence; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D019965:Neurocognitive Disorders / Q000209:etiology*; D011618:Psychotic Disorders / Q000209:etiology*; D012559:Schizophrenia / Q000209:etiology