title: The month of July: an early experience with pandemic influenza A (H1N1) in adults with cystic fibrosis.
abstract: BACKGROUND
  Pandemic Influenza A (H1N1) 2009 is a novel viral infection that emerged in March 2009. This is the first report addressing the clinical course of patients with cystic fibrosis (CF) and H1N1 infection.
  
  
  METHODS
  All patients with an influenza-like illness (ILI) attending our adult centre during July 2009 were identified. Baseline respiratory function, nutritional status, approach to management and short-term clinical course were recorded.
  
  
  RESULTS
  Most patients experienced a mild course and were able to be managed with antiviral agents as an outpatient. Robust infection control policies were implemented to limit transmission of H1N1 infection within our CF centre. Patients with severe lung disease, poor baseline nutritional reserve and presenting with more than 48 hours of ILI experienced a more severe course. Prompt antiviral therapy within the first 48 hours of illness may have been important in improving outcomes.
  
  
  CONCLUSIONS
  This observational study demonstrates that most adults with CF with H1N1 infection had mild clinical courses and recovered rapidly.
authors.affiliation: The Prince Charles Hospital Adult Cystic Fibrosis Centre, Rode Rd, Chermside, Queensland 4032, Australia. megan_france@hotmail.com
authors.forename: Megan W
authors.initials: MW
authors.lastname: France
authors.forename: Szeanna
authors.initials: S
authors.lastname: Tai
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Masel
authors.forename: Vanessa L
authors.initials: VL
authors.lastname: Moore
authors.forename: Tracy L
authors.initials: TL
authors.lastname: McMahon
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Ritchie
authors.forename: Scott C
authors.initials: SC
authors.lastname: Bell
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D003151:Community Health Centers / Q000706:statistics & numerical data; D003550:Cystic Fibrosis / Q000453:epidemiology*; D004196:Disease Outbreaks / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000188:drug therapy / Q000453:epidemiology*; D008297:Male; D011793:Queensland / Q000453:epidemiology; D012621:Seasons; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D000998:Antiviral Agents