title: Attenuation of experimental murine colitis by acanthoic acid from Acanthopanax koreanum.
abstract: Acanthoic acid (AA) is a pimaradiene diterpene isolated from Acanthopanax koreanum. We examined the effect of AA in dextran sulfate sodium (DSS)-induced colitis. AA (100 mg/kg or 300 mg/kg) was administered p.o. daily for 7 days. AA significantly inhibited Disease Activity Index, histological score, and myeloperoxidase activity. Furthermore, AA markedly suppressed the protein expression of TNF-alpha, COX-2, NF-kappaB and chymase as well as the mRNA expression of TNF-alpha and COX-2. These results suggest that AA exerts beneficial effects in experimental colitis, and therefore we propose that this compound may have therapeutic implications for ulcerative colitis.
authors.affiliation: Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University and Wonkwang-Oriental Medicines Research Institute, Iksan 570-749, Korea.
authors.forename: Ok-Hwa
authors.initials: OH
authors.lastname: Kang
authors.forename: Dae-Ki
authors.initials: DK
authors.lastname: Kim
authors.forename: Xing-Fu
authors.initials: XF
authors.lastname: Cai
authors.forename: Young-Ho
authors.initials: YH
authors.lastname: Kim
authors.forename: Young-Mi
authors.initials: YM
authors.lastname: Lee
mesh_terms: D000818:Animals; D015153:Blotting, Western; D001835:Body Weight / Q000187:drug effects; D053818:Chymases / Q000096:biosynthesis; D003093:Colitis, Ulcerative / Q000188:drug therapy* / Q000473:pathology; D003106:Colon / Q000473:pathology; D051546:Cyclooxygenase 2 / Q000096:biosynthesis; D003967:Diarrhea / Q000188:drug therapy / Q000209:etiology; D004224:Diterpenes / Q000737:chemistry* / Q000627:therapeutic use*; D028001:Eleutherococcus / Q000737:chemistry*; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy / Q000209:etiology; D051379:Mice; D008807:Mice, Inbred BALB C; D016328:NF-kappa B / Q000096:biosynthesis; D009195:Peroxidase / Q000378:metabolism; D018517:Plant Roots / Q000737:chemistry; D012333:RNA, Messenger / Q000096:biosynthesis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: D004224:Diterpenes; D016328:NF-kappa B; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; C099958:acanthoic acid; D009195:Peroxidase; D051546:Cyclooxygenase 2; D053818:Chymases