title: Contemporary perioperative results of isolated aortic valve replacement for aortic stenosis.
abstract: BACKGROUND
  Transcatheter aortic valve implantation may become a potential treatment for high-risk patients with aortic stenosis (AS). We analyzed our contemporary series of isolated aortic valve replacement (AVR) for AS to determine implications for patients referred for AVR.
  
  
  METHODS
  From April 2004 through December 2008, 190 patients (mean age, 68 years; 68% men) underwent isolated AVR for AS. Mean ejection fraction was 0.58. Sixty-one percent underwent minimally invasive AVR and 18% were reoperations. Twenty-one percent were aged 80 years or older, and 34% were in New York Heart Association functional class III-IV. Estimated operative mortality was 3.6%.
  
  
  RESULTS
  Thirty-day mortality was 0%. One in-hospital death (0.5%) occurred from complications of an esophageal perforation. Reoperation for bleeding occurred in 4.7%. Acute renal failure developed in 2.1%. Actuarial survival was 97% at 1 year and 94% at 3 years. Hospital length of stay was 7.0 days for patients aged 80 and older vs 5.0 days (p < 0.001), and they were less likely to be discharged to home (50% vs 83%, p < 0.001).
  
  
  CONCLUSIONS
  Contemporary results show that AVR for AS can be performed with low operative mortality and morbidity, although patients aged 80 years and older are at increased risk of prolonged recovery. Transcatheter aortic valve implantation may be an alternative for high-risk patients, but AVR is still appropriate for low-risk patients. The low risk of AVR supports the argument that asymptomatic patients who have a high likelihood of progression of AS may be considered for earlier surgical referral.
authors.affiliation: Division of Cardiothoracic Surgery, Northwestern University, Feinberg School of Medicine, Bluhm Cardiovascular Institute at Northwestern Memorial Hospital, Chicago, Illinois, USA. cmalaisr@nmh.org
authors.forename: S Chris
authors.initials: SC
authors.lastname: Malaisrie
authors.forename: Patrick M
authors.initials: PM
authors.lastname: McCarthy
authors.forename: Edwin C
authors.initials: EC
authors.lastname: McGee
authors.forename: Richard
authors.initials: R
authors.lastname: Lee
authors.forename: Vera H
authors.initials: VH
authors.lastname: Rigolin
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Davidson
authors.forename: Nirat
authors.initials: N
authors.lastname: Beohar
authors.forename: Brittany
authors.initials: B
authors.lastname: Lapin
authors.forename: Haris
authors.initials: H
authors.lastname: Subacius
authors.forename: Robert O
authors.initials: RO
authors.lastname: Bonow
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000601:surgery*; D005260:Female; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000401:mortality; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D015996:Survival Rate