Synthesis of an enantiopure isoxazolidine monomer for β-aspartic acid in chemoselective β-oligopeptide synthesis.
The synthesis of an enantiopure isoxazolidine monomer for the incorporation of β(3)-apartic acid residues into β(3)-oligopeptides via chemoselective α-ketoacid-hydroxylamine amide formation. This route involves nitrone cycloaddition of 3-thiophenylpropanal and circumvents limitations of other potential starting materials.
Ishida
Hiroshi
H
Roy and Diana Vagelos Laboratories, Department of Chemistry, Univeristy of Pennsylvania, Philadelphia, PA 19104.
Carrillo
Nancy
N
Bode
Jeffrey W
JW