title: Beneficial effect of xylo-oligosaccharides and fructo-oligosaccharides in streptozotocin-induced diabetic rats.
abstract: The beneficial influences of xylo-oligosaccharides (XOS) obtained from alkali-pretreated corncob and fructo-oligosaccharides (FOS) obtained from cane sugar were evaluated in experimental diabetes. These oligosaccharides were supplemented at 10 % (w/w) in the basal diet of streptozotocin-induced diabetic Wistar rats, while the control rats were fed with a basal diet for a period of 6 weeks. Both the oligosaccharides exerted favourable influences in diabetic rats by significantly improving body weight and reducing hyperglycaemia and cholesterol. The characteristic diabetic complications such as severe glucosuria, proteinuria and advanced glycation end products in renal tissue, diabetic nephropathy, and blood creatinine and urea concentrations were notably reduced. Besides, these oligosaccharide supplementations significantly increased the activity of antioxidant enzymes - catalase and glutathione reductase - in the blood of diabetic rats. Supplementation of XOS and FOS resulted in a significant increase in the bifidobacteria and lactobacilli population in the caecum. The present study indicates that XOS and FOS have an ameliorating influence on metabolic abnormalities associated with diabetes, besides conferring an optimal milieu of lactobacilli and bifidobacteria, thus suggesting their potential health benefit in diabetics.
authors.affiliation: Department of Fermentation Technology & Bioengineering, Central Food Technological Research Institute, CSIR, Mysore 570 020, India.
authors.forename: Duraiswamy
authors.initials: D
authors.lastname: Gobinath
authors.forename: Arenahalli N
authors.initials: AN
authors.lastname: Madhu
authors.forename: Giribhattanavar
authors.initials: G
authors.lastname: Prashant
authors.forename: Krishnapura
authors.initials: K
authors.lastname: Srinivasan
authors.forename: Siddalingaiya G
authors.initials: SG
authors.lastname: Prapulla
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D001644:Bifidobacterium; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects*; D002432:Cecum / Q000382:microbiology; D048909:Diabetes Complications / Q000188:drug therapy* / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D019587:Dietary Supplements; D006943:Hyperglycemia / Q000188:drug therapy / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D007778:Lactobacillus; D008297:Male; D009844:Oligosaccharides / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D031786:Saccharum / Q000737:chemistry; D003313:Zea mays / Q000737:chemistry
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007004:Hypoglycemic Agents; D009844:Oligosaccharides; D028321:Plant Preparations