Brief spatial experiences increase granule cell survival in the dentate gyrus of adult rats.
Rats of two experimental groups were placed in an open-field apparatus for 3-5 spatial exploration, each placement lasting 5min (total duration of 15-25min), and had a significantly greater newborn-neuron survival rate of the granule cells than the control group by evaluating the density of 5-bromo-2'deoxyuridine positive cells in the dentate gyrus. This study suggests that brief spatial experiences are sufficient to enhance the survival rate of newborn neurons.
Feng
Kuan-Lin
KL
Department of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
Wang
Su-Ping
SP
Wu
Yi-Sian
YS
Lin
Pei-Yi
PY
Tai
Mei-Yun
MY
Tsai
Yuan-Feen
YF
D000375:Aging; D000704:Analysis of Variance; D000818:Animals; D001973:Bromodeoxyuridine; D002452:Cell Count; D002470:Cell Survival / Q000502:physiology; D018891:Dentate Gyrus / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology; D008297:Male; D055495:Neurogenesis; D009474:Neurons / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D020318:Rats, Long-Evans; D013028:Space Perception / Q000502:physiology*; D013997:Time Factors
D001973:Bromodeoxyuridine