title: Pathogenesis of contact lens-associated microbial keratitis.
abstract: Sight-threatening microbial keratitis associated with contact lens wear remains a serious concern for patients, eye-care practitioners, and the contact lens industry. Several decades of research and some major advances in lens and solution technology have not resulted in a decline in disease incidence. Here, we offer a perspective on the complex pathogenesis of microbial keratitis, the factors that have prevented a better understanding of this disease, and new approaches being used to tackle this important clinical problem.
authors.affiliation: School of Optometry and Graduate Programs in Vision Science, Microbiology, Infectious Disease and Immunity, and Health and Medical Sciences, University of California-Berkeley, Berkeley, CA, USA. fleiszig@berkeley.edu
authors.forename: Suzanne M J
authors.initials: SM
authors.lastname: Fleiszig
authors.forename: David J
authors.initials: DJ
authors.lastname: Evans
mesh_terms: D000818:Animals; D001419:Bacteria / Q000302:isolation & purification*; D003261:Contact Lenses / Q000009:adverse effects* / Q000382:microbiology; D003315:Cornea / Q000382:microbiology* / Q000473:pathology; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D006801:Humans; D007634:Keratitis / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D012307:Risk Factors