Relationship between growth hormone 1 genetic polymorphism and susceptibility to colorectal cancer.
The aim of this study was to evaluate the relationship between smoking, alcohol drinking and genetic polymorphism of the growth hormone 1 gene (GH1) T1663A with reference to colorectal cancer. We conducted a case-control study with 315 cases of colorectal cancer and 438 population-based controls in the Jiangsu Province, China. GH1 T1663A genotypes were identified using PCR-RFLP (restriction fragment length polymorphism) methods. Information on smoking and drinking was collected using a questionnaire. Odds ratios (ORs) were estimated with an unconditional logistic model. The distribution of T/T and A/A genotypes was significantly different between controls and cases (chi(2)(MH)=3.877, P=0.049). Compared with the GH1 T/T genotype, the A/A genotype was at a decreased risk of developing colorectal cancer (sex-, age-, body mass index-, smoking- and alcohol drinking-adjusted OR=0.56, 95% confidence interval: 0.34-0.90). Smoking was not associated with the risk of colorectal cancer, whereas alcohol drinking was associated with an increased risk of colorectal cancer. Among nonsmokers or nondrinkers, individuals who had the GH1 A/A genotype were at a decreased risk of developing colorectal cancer compared with individuals who had the GH1 T allele. These results show that the GH1 T1663A A/A genotype can decrease the risk for colorectal cancer.
Gao
Chang-Ming
CM
Division of Epidemiology, Jiangsu Provincial Institute of Cancer Research, Nanjing, Jiangsu Province, China. gaocm888@126.com
Gong
Jian-Ping
JP
Wu
Jian-Zhong
JZ
Cao
Hai-Xia
HX
Ding
Jian-Hua
JH
Zhou
Jian-Nong
JN
Liu
Yan-Ting
YT
Li
Su-Ping
SP
Cao
Jia
J
Matsuo
Keitaro
K
Takezaki
Toshiro
T
Tajima
Kazuo
K
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking / Q000235:genetics; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D019382:Human Growth Hormone / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012907:Smoking / Q000235:genetics
D019382:Human Growth Hormone