title: Solid-phase synthesis of peptide-viologen conjugates.
abstract: This paper presents a robust method for the conjugation of viologens to peptides using an amide coupling strategy that is compatible with standard Fmoc solid-phase peptide synthesis. Methodology is presented for monitoring the milligram scale process quantitatively by UV spectroscopy. This chemistry enables the synthesis of a broad range of asymmetric viologens in high yield at room temperature and is compatible with a wide range of functional groups, including amine, guanidinyl, thiol, carboxylic acid, phenol, and indole.
authors.affiliation: Department of Chemistry, Trinity University, San Antonio, Texas 78212, USA.
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Reczek
authors.forename: Elisa
authors.initials: E
authors.lastname: Rebolini
authors.forename: Adam R
authors.initials: AR
authors.lastname: Urbach
mesh_terms: D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D014755:Viologens / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D010455:Peptides; D014755:Viologens