title: Brain glucose overexposure and lack of acute metabolic flexibility in obesity and type 2 diabetes: a PET-[18F]FDG study in Zucker and ZDF rats.
abstract: Brain glucose exposure may complicate diabetes and obesity. We used positron emission tomography with (18)F-fluorodeoxyglucose in Zucker obese, diabetic, and control rats to determine the contributions of blood glucose mass action versus local mechanisms in regulating central glucose disposal in fasted and acutely glucose-stimulated states, and their adaptations in obesity and diabetes. Our study data indicate that brain glucose uptake is dependent on both local and mass action components, and is stimulated by acute glucose intake in healthy rats. In diseased animals, the organ was chronically overexposed to glucose, due to high fasting glucose uptake, almost abolishing the physiologic response to glucose loading.
authors.affiliation: Institute of Clinical Physiology, National Research Council (CNR), Pisa, Italy.
authors.forename: Tiziana
authors.initials: T
authors.lastname: Liistro
authors.forename: Letizia
authors.initials: L
authors.lastname: Guiducci
authors.forename: Silvia
authors.initials: S
authors.lastname: Burchielli
authors.forename: Daniele
authors.initials: D
authors.lastname: Panetta
authors.forename: Nicola
authors.initials: N
authors.lastname: Belcari
authors.forename: Silvia
authors.initials: S
authors.lastname: Pardini
authors.forename: Alberto
authors.initials: A
authors.lastname: Del Guerra
authors.forename: Piero A
authors.initials: PA
authors.lastname: Salvadori
authors.forename: Patricia
authors.initials: P
authors.lastname: Iozzo
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D005215:Fasting; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism*; D008297:Male; D009765:Obesity / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D049268:Positron-Emission Tomography; D051381:Rats; D011924:Rats, Zucker
chemical_list: D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18