title: Backbone chemical shift assignments of the acyl-acyl carrier protein intermediates of the fatty acid biosynthesis pathway of Plasmodium falciparum.
abstract: We report the backbone chemical shift assignments of the acyl-acyl carrier protein (ACP) intermediates of the fatty acid biosynthesis pathway of Plasmodium falciparum. The acyl-ACP intermediates butyryl (C(4)), -octanoyl (C(8)), -decanoyl (C(10)), -dodecanoyl (C(12)) and -tetradecanoyl (C(14))-ACPs display marked changes in backbone HN, C(alpha) and C(beta) chemical shifts as a result of acyl chain insertion into the hydrophobic core. Chemical shift changes cast light on the mechanism of expansion of the acyl carrier protein core.
authors.affiliation: National Institute of Immunology, Aruna Asaf Ali Marg, JNU Campus, New Delhi 110067, India.
authors.forename: Santosh Kumar
authors.initials: SK
authors.lastname: Upadhyay
authors.forename: Ashish
authors.initials: A
authors.lastname: Misra
authors.forename: Namita
authors.initials: N
authors.lastname: Surolia
authors.forename: Avadhesha
authors.initials: A
authors.lastname: Surolia
authors.forename: Monica
authors.initials: M
authors.lastname: Sundd
mesh_terms: D000213:Acyl Carrier Protein / Q000737:chemistry*; D004926:Escherichia coli; D005227:Fatty Acids / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D010963:Plasmodium falciparum / Q000737:chemistry*; D015800:Protozoan Proteins / Q000737:chemistry*
chemical_list: D000213:Acyl Carrier Protein; D005227:Fatty Acids; D015800:Protozoan Proteins