A MRI and polarized gases compatible respirator and gas administrator for the study of the small animal lung: volume measurement and control.
We have developed over the past years an experimental magnetic resonance imaging (MRI) and polarized gases compatible mechanical respirator for the study of the small experimental animal. The respirator has been successfully used for experiments both in the MRI setting for polarized (3)He, (19)F, and proton imaging as well as for functional measurements of the lungs. The new main pneumatic valve with the two integrated sensors for simultaneous lung pressure and volume measurements and the proportional valve to set the tidal volume of the respiration are described. It is shown how the device measures and controls the tidal volume of the lungs.
Kyriazis
Angelos
A
Instituto de Estudios Biofuncionales, Universidad Complutense de Madrid, Madrid 28040, Spain. angelos@ieb.ucm.es
Perez de Alejo
Rigoberto
R
Rodriguez
Ignacio
I
Olsson
Lars E
LE
Ruiz-Cabello
Jesus
J
D000818:Animals; D035843:Biomedical Research / Q000295:instrumentation*; D005740:Gases; D008170:Lung Compliance; D008176:Lung Volume Measurements; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D012122:Ventilators, Mechanical
D005740:Gases