title: New adjuvants to enhance anticoagulant activity of warfarin.
abstract: New adjuvants of warfarin anticoagulant activity have been developed. These compounds, which are 1,4-methano-1,2,3,4-tetrahydroanthracene-9,10-diol derivatives, act synergistically with warfarin to potentiate its anticoagulant effect. None of the compounds tested is an effective oral anticoagulant in the absence of warfarin.
authors.affiliation: Department of Chemistry, University of Wisconsin-Eau Claire, Eau Claire, WI 54702, USA.
authors.forename: Jeremiah J
authors.initials: JJ
authors.lastname: Stromich
authors.forename: Ashley K
authors.initials: AK
authors.lastname: Weber
authors.forename: Yousef R
authors.initials: YR
authors.lastname: Mirzaei
authors.forename: Michael D
authors.initials: MD
authors.lastname: Caldwell
authors.forename: David E
authors.initials: DE
authors.lastname: Lewis
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014859:Warfarin / Q000494:pharmacology*
chemical_list: D000925:Anticoagulants; D014859:Warfarin