Synthesis of labeled meropenem for the analysis of M. tuberculosis transpeptidases.
A concise synthesis of (14)C labeled meropenem prepared from (14)C dimethylamine hydrochloride is described. Using a similar reaction sequence, the meropenem nucleus was also attached to biotin providing a probe for protein interaction studies.
Kastrinsky
David B
DB
The National Institutes of Health, National Institute of Allergy and Infectous Diseases, Tuberculosis Research Section, Bethesda MD 20892.
Barry
Clifton E
CE