title: Acute kidney injury in sickle patients with painful crisis or acute chest syndrome and its relation to pulmonary hypertension.
abstract: BACKGROUND
  The association between chronic kidney involvement and sickle cell disease (SCD) has been well characterized, but our knowledge on acute kidney injury (AKI) in relation to SCD remains limited.
  
  
  METHODS
  We retrospectively assessed 254 episodes of vaso-occlusive complication in 161 SCD patients who were admitted to our hospital: these included 174 episodes of painful crisis (PC), 58 episodes of moderate acute chest syndrome (ACS) and 22 episodes of severe ACS.
  
  
  RESULTS
  The overall incidence of AKI [defined according to Acute Kidney Injury Network (AKIN) criteria] during vaso-occlusive complications was low (4.3%) but seemed to be related to its severity: 2.3% for PC vs 6.9% for moderate ACS and 13.6% for severe ACS (P = 0.03). This finding led us prospectively to look at specific risk factors for AKI occurrence in SCD patients admitted to our intensive care unit for severe ACS and, in particular, the possible link between AKI and haemodynamic status (transthoracic echocardiography). Among patients with severe ACS, those with AKI displayed significantly greater aminotransferases, bilirubin and lactate dehydrogenase levels than patients without AKI. Echocardiography identified higher systolic pulmonary artery pressure in patients with AKI than in those without, whereas the cardiac index was similar between groups.
  
  
  CONCLUSIONS
  AKI incidence during vaso-occlusive complications of SCD is relatively low (<5%) and appears to be confined to patients with ACS and pulmonary hypertension. These findings suggest a pathophysiological process involving right ventricular dysfunction and venous congestion.
authors.affiliation: Nephrology and Renal Transplantation Department and Institut Francilien de Recherche en Nephrologie et Transplantation (IFRNT), Henri Mondor Hospital, 51 Avenue du Marechal de Lattre de Tassigny Creteil, France. vincent.audard@hmn.aphp.fr
authors.forename: Vincent
authors.initials: V
authors.lastname: Audard
authors.forename: Sébastien
authors.initials: S
authors.lastname: Homs
authors.forename: Anoosha
authors.initials: A
authors.lastname: Habibi
authors.forename: Frederic
authors.initials: F
authors.lastname: Galacteros
authors.forename: Pablo
authors.initials: P
authors.lastname: Bartolucci
authors.forename: Bertrand
authors.initials: B
authors.lastname: Godeau
authors.forename: Bertrand
authors.initials: B
authors.lastname: Renaud
authors.forename: Yves
authors.initials: Y
authors.lastname: Levy
authors.forename: Philippe
authors.initials: P
authors.lastname: Grimbert
authors.forename: Philippe
authors.initials: P
authors.lastname: Lang
authors.forename: Christian
authors.initials: C
authors.lastname: Brun-Buisson
authors.forename: Laurent
authors.initials: L
authors.lastname: Brochard
authors.forename: Frederique
authors.initials: F
authors.lastname: Schortgen
authors.forename: Bernard
authors.initials: B
authors.lastname: Maitre
authors.forename: Armand
authors.initials: A
authors.lastname: Mekontso Dessap
mesh_terms: D056586:Acute Chest Syndrome / Q000150:complications*; D058186:Acute Kidney Injury / Q000453:epidemiology*; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications*; D015994:Incidence; D007362:Intensive Care Units; D008297:Male; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index