Bioinspired synthesis and characterization of gadolinium-labeled magnetite nanoparticles for dual contrast t1- and T2-weighted magnetic resonance imaging.
Gadolinium-labeled magnetite nanoparticles (GMNPs) were synthesized via a bioinspired manner to use as dual contrast agents for T1- and T2-weighted magnetic resonance imaging. A mussel-derived adhesive moiety, 3,4-dihydroxy-l-phenylalanine (DOPA), was utilized as a robust anchor to form a mixed layer of poly(ethylene glycol) (PEG) chains and dopamine molecules on the surface of iron oxide nanoparticles. Gadolinium ions were subsequently complexed at the distal end of the dopamine molecules that were prefunctionalized with a chelating ligand for gadolinium. The resultant GMNPs exhibited high dispersion stability in aqueous solution. Crystal structure and superparamagnetic properties of magnetite nanocrystals were also maintained after the complexation of gadolinium. The potential of GMNPs as dual contrast agents for T1 and T2-weighted magnetic resonance imaging was demonstrated by conducting in vitro and in vivo imaging and relaxivity measurements.
Bae
Ki Hyun
KH
Department of Biological Sciences and Graduate School of Nanoscience and Technology, and Department of Electrical Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, South Korea.
Kim
Young Beom
YB
Lee
Yuhan
Y
Hwang
Jinyoung
J
Park
Hyunwook
H
Park
Tae Gwan
TG
D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry; D005682:Gadolinium / Q000008:administration & dosage / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D015394:Molecular Structure; D008970:Molecular Weight; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000737:chemistry; D010316:Particle Size; D013499:Surface Properties; D051598:Whole Body Imaging
D003287:Contrast Media; D058185:Magnetite Nanoparticles; D009942:Organometallic Compounds; D005682:Gadolinium