Caffeine increases cerebral cortical activity in preterm infants.
Caffeine improves the rate of survival without neurodevelopmental disability in preterm infants. The mechanisms underlying neuroprotection are incompletely understood. In 51 preterm infants studied by amplitude-integrated electroencephalography from 2 hours before to 2 hours after intravenous caffeine administration, we found that caffeine increases amplitudes and periods of continuity.
Supcun
Sirma
S
Department of Neonatology and Pediatric Intensive Care, Vest Children's Hospital, University of Witten-Herdecke, Datteln, Germany.
Kutz
Patrizia
P
Pielemeier
Wolfgang
W
Roll
Claudia
C
D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D004569:Electroencephalography / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007262:Infusions, Intravenous; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000494:pharmacology*
D018696:Neuroprotective Agents; D002110:Caffeine