title: High-level human herpesvirus-6 viremia associated with onset of Stevens-Johnson syndrome: report of two cases.
abstract: The pathogenesis of Stevens-Johnson syndrome (SJS) remains obscure, but it has been associated with various infectious agents, including members of the herpesvirus family. We present the first report of high-level human herpesvirus-6 viremia at the onset of SJS, suggesting a possible new association. This finding supports the need for further investigation into the possible relationship between human herpesvirus-6 and SJS, which may illuminate the pathogenesis of SJS and bring us closer to achieving enhanced prevention and treatment of this rare disease.
authors.affiliation: Department of Medicine, University of North Carolina, School of Medicine, Chapel Hill, USA.
authors.forename: Amanda F
authors.initials: AF
authors.lastname: Peppercorn
authors.forename: Melissa B
authors.initials: MB
authors.lastname: Miller
authors.forename: David
authors.initials: D
authors.lastname: Fitzgerald
authors.forename: David J
authors.initials: DJ
authors.lastname: Weber
authors.forename: Pamela A
authors.initials: PA
authors.lastname: Groben
authors.forename: Bruce A
authors.initials: BA
authors.lastname: Cairns
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D005260:Female; D015654:Herpesvirus 6, Human; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use; D008875:Middle Aged; D019349:Roseolovirus Infections / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology*; D014766:Viremia / Q000821:virology
chemical_list: D007074:Immunoglobulin G