A Robust QTL Mapping Procedure.
In quantitative-trait linkage studies using experimental crosses, the conventional normal location-shift model or other parameterizations may be unnecessarily restrictive. We generalize the mapping problem to a genuine nonparametric setup and provide a robust estimation procedure for the situation where the underlying phenotype distributions are completely unspecified. Classical Wilcoxon-Mann-Whitney statistics are employed for point and interval estimation of QTL positions and effects.
Zou
Fei
F
Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599.
Nie
Lei
L
Wright
Fred A
FA
Sen
Pranab K
PK