Effects of human T-cell leukemia virus type 1 (HTLV-1) p13 on mitochondrial K+ permeability: A new member of the viroporin family?
Human T-cell leukemia virus type-1 (HTLV-1) encodes a mitochondrial protein named p13. p13 mediates an inward K(+) current in isolated mitochondria that leads to mitochondrial swelling, depolarization, increased respiratory chain activity and reactive oxygen species (ROS) production. These effects trigger the opening of the permeability transition pore and are dependent on the presence of K(+) and on the amphipathic alpha helical domain of p13. In the context of cells, p13 acts as a sensitizer to selected apoptotic stimuli. Although it is not known whether p13 influences the activity of endogenous K(+) channels or forms a channel itself, it shares some structural and functional analogies with viroporins, a class of small integral membrane proteins that form pores and alter membrane permeability.
Silic-Benussi
Micol
M
Department of Oncology and Surgical Sciences, University of Padova, I-35128 Padova, Italy.
Marin
Oriano
O
Biasiotto
Roberta
R
D'Agostino
Donna M
DM
Ciminale
Vincenzo
V
D000595:Amino Acid Sequence; D000818:Animals; D002472:Cell Transformation, Viral / Q000187:drug effects; D015368:Human T-lymphotropic virus 1; D006801:Humans; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism*; D008969:Molecular Sequence Data; D010539:Permeability / Q000187:drug effects; D011188:Potassium / Q000378:metabolism*; D012191:Retroviridae Proteins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*
D012191:Retroviridae Proteins; C072813:rof protein, Human T-lymphotropic virus 1; D011188:Potassium