New adjuvants to enhance anticoagulant activity of warfarin.
New adjuvants of warfarin anticoagulant activity have been developed. These compounds, which are 1,4-methano-1,2,3,4-tetrahydroanthracene-9,10-diol derivatives, act synergistically with warfarin to potentiate its anticoagulant effect. None of the compounds tested is an effective oral anticoagulant in the absence of warfarin.
Stromich
Jeremiah J
JJ
Department of Chemistry, University of Wisconsin-Eau Claire, Eau Claire, WI 54702, USA.
Weber
Ashley K
AK
Mirzaei
Yousef R
YR
Caldwell
Michael D
MD
Lewis
David E
DE
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014859:Warfarin / Q000494:pharmacology*
D000925:Anticoagulants; D014859:Warfarin