Effects of 5'-uridylic acid feeding on postprandial plasma concentrations of metabolites and metabolic hormones in pre-weaning goats.
5'-Uridylic acid (UMP), which is present at high concentrations in cow's colostrum, has been shown to cause a reduction in increased plasma levels of insulin and glucose after ingestion of milk replacer in pre-weaning calves. However, the precise mechanisms of UMP action have not been investigated, and its action has not been investigated in other pre-weaning ruminants. In order to demonstrate whether UMP causes changes in postprandial metabolic and hormonal parameters in pre-weaning goats, 11 Saanen kids were given milk replacer (twice a day) without (n = 5) or with (n = 6) UMP (1 g for each meal, 2 g/day for each head) for 14 days. Analysis of blood samples taken in the morning of day 14 demonstrated that the feeding of milk replacer with UMP abolished the significant changes in postprandial plasma glucose, NEFA, GH and insulin concentrations induced by feeding of milk replacer alone, and demonstrated a tendency to increase IGF-I levels. However, there was no significant difference between the two groups at any sampling time. We conclude that UMP feeding with milk replacer showed a tendency to blunt the postprandial changes in levels of some plasma metabolites and hormones that are induced by replacer alone in pre-weaning goats.
Ohtani
Yoshihisa
Y
Department of Animal Physiology, Graduate School of Agricultural Science, Tohoku University, Aoba-ku, Sendai 981-8555, Japan.
Kobayashi
Yosuke
Y
Takahashi
Tatsuyuki
T
Haga
Satoshi
S
Takagi
Mutsuo
M
Mashiko
Takanori
T
Katoh
Kazuo
K
Obara
Yoshiaki
Y
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000833:Animals, Suckling / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism*; D003126:Colostrum / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006041:Goats; D013006:Growth Hormone / Q000097:blood*; D007328:Insulin / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008892:Milk / Q000378:metabolism; D041941:Milk Substitutes / Q000378:metabolism*; D019518:Postprandial Period / Q000502:physiology; D014542:Uridine Monophosphate / Q000008:administration & dosage*; D014886:Weaning
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D014542:Uridine Monophosphate