BVMO-catalysed dynamic kinetic resolution of racemic benzyl ketones in the presence of anion exchange resins.
4-Hydroxyacetophenone monooxygenase from Pseudomonas fluorescens ACB was employed in the presence of a weak anion exchange resin to perform dynamic kinetic resolutions of racemic benzyl ketones with high conversions and good optical purities. Different parameters that affect to the efficiency of the enzymatic Baeyer-Villiger oxidation and racemisation were analyzed in order to optimize the activity and selectivity of the biocatalytic system.
Rodríguez
Cristina
C
Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, C/Julián Clavería 8, 33006, Oviedo, Spain.
de Gonzalo
Gonzalo
G
Rioz-Martínez
Ana
A
Torres Pazmiño
Daniel E
DE
Fraaije
Marco W
MW
Gotor
Vicente
V
D000837:Anion Exchange Resins / Q000737:chemistry / Q000378:metabolism*; D055162:Biocatalysis; D006841:Hydrocarbons, Aromatic / Q000737:chemistry / Q000378:metabolism; D007659:Ketones / Q000737:chemistry / Q000378:metabolism*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010105:Oxygenases / Q000378:metabolism*; D011551:Pseudomonas fluorescens / Q000201:enzymology*
D000837:Anion Exchange Resins; D006841:Hydrocarbons, Aromatic; D007659:Ketones; D010105:Oxygenases; C427385:4-hydroxyacetophenone monooxygenase