The peroxisomal protein importomer: a bunch of transients with expanding waistlines.
Peroxisomes can import large multimeric protein complexes and even 9-nm gold particles decorated with peroxisome-targeting signals. They achieve these feats of protein passage using a distinctive translocon whose highly dynamic aqueous pore can expand to accommodate the increasing girths of different peroxisome receptor-cargo complexes.
Mast
Fred D
FD
Department of Cell Biology, University of Alberta, Edmonton, Alberta T6G 2H7, Canada.
Fagarasanu
Andrei
A
Rachubinski
Richard
R
D042962:Acyl-CoA Oxidase / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000502:physiology; D008565:Membrane Proteins / Q000032:analysis / Q000502:physiology; D026901:Membrane Transport Proteins / Q000032:analysis / Q000502:physiology*; D008567:Membranes, Artificial; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000737:chemistry / Q000302:isolation & purification / Q000502:physiology*; D000074401:Peroxins; D000074435:Peroxisome-Targeting Signal 1 Receptor; D020675:Peroxisomes / Q000502:physiology*; D018272:Porins / Q000032:analysis / Q000502:physiology*; D021381:Protein Transport / Q000502:physiology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000032:analysis / Q000502:physiology; D012097:Repressor Proteins / Q000032:analysis / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000737:chemistry / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D044767:Ubiquitin-Protein Ligases / Q000032:analysis / Q000502:physiology
D002352:Carrier Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D008567:Membranes, Artificial; D046912:Multiprotein Complexes; C492057:PEX10 protein, S cerevisiae; C491335:PEX12 protein, S cerevisiae; C491105:PEX13 protein, S cerevisiae; C499195:PEX14 protein, S cerevisiae; C491361:PEX17 protein, S cerevisiae; C116845:PEX18 protein, S cerevisiae; C116846:PEX21 protein, S cerevisiae; C499509:PEX5 protein, S cerevisiae; D000074401:Peroxins; D000074435:Peroxisome-Targeting Signal 1 Receptor; C404515:Pex8 protein, S cerevisiae; D018272:Porins; D018160:Receptors, Cytoplasmic and Nuclear; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D042962:Acyl-CoA Oxidase; C467991:POX1 protein, S cerevisiae; D044767:Ubiquitin-Protein Ligases