title: Effects of multivitamin/mineral supplementation on trace element levels in serum and follicular fluid of women undergoing in vitro fertilization (IVF).
abstract: We investigated effects of multivitamin/mineral supplementation on element levels in serum and follicular fluid of women undergoing IVF. We used three groups in this study. The first group was used as an age-matched and nonpregnant control (n = 13). Group 2 (n = 30) constituted the IVF group and women in the third group who were undergoing IVF also received a multivitamin/mineral tablet daily for 45 days. Follicular fluid and serum selenium and zinc levels and follicular fluid copper levels were lower in IVF patients than in controls although follicular fluid aluminum and iron levels were higher in IVF patients than in controls. However, follicular fluid and serum aluminum, copper, zinc and selenium levels, and serum magnesium levels were higher in the multivitamin/mineral group than in the IVF group although follicular fluid iron levels were lower in the multivitamin/mineral group than in the IVF group. In conclusion, we observed that copper, zinc, and selenium in serum and follicular fluid decreased in women undergoing IVF. Multivitamin/mineral supplementation in serum and follicular fluid of women undergoing IVF normalized the trace element levels.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Mehmet Okan
authors.initials: MO
authors.lastname: Özkaya
authors.forename: Mustafa
authors.initials: M
authors.lastname: Nazıroğlu
authors.forename: Cihan
authors.initials: C
authors.lastname: Barak
authors.forename: Murat
authors.initials: M
authors.lastname: Berkkanoglu
mesh_terms: D000328:Adult; D000535:Aluminum / Q000097:blood / Q000378:metabolism; D002118:Calcium / Q000097:blood / Q000378:metabolism; D003300:Copper / Q000097:blood / Q000378:metabolism; D019587:Dietary Supplements; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000737:chemistry*; D006801:Humans; D007501:Iron / Q000097:blood / Q000378:metabolism; D008274:Magnesium / Q000097:blood / Q000378:metabolism; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use*; D012643:Selenium / Q000097:blood / Q000378:metabolism; D014131:Trace Elements / Q000627:therapeutic use*; D014815:Vitamins / Q000627:therapeutic use*; D055815:Young Adult; D015032:Zinc / Q000097:blood / Q000378:metabolism
chemical_list: D008903:Minerals; D014131:Trace Elements; D014815:Vitamins; D003300:Copper; D000535:Aluminum; D007501:Iron; D012643:Selenium; D008274:Magnesium; D015032:Zinc; D002118:Calcium