title: Guillain-Barré syndrome as a paraneoplastic manifestation of small-cell carcinoma of lung.
abstract: Guillain-Barré syndrome (GBS) encompasses the variants of acute immune-mediated polyneuropathies usually preceded by an infection. A few case reports have associated GBS to neoplastic diseases. It remains unclear whether these are merely coincidental or represent paraneoplastic phenomena. The clinical features of GBS associated with oncological cases do not appear to differ from post-infectious GBS. We report a 74-year-old man in whom small cell carcinoma of lung (SCLC) was diagnosed during a presentation with GBS. Treatment with chemotherapy for SCLC and intravenous immunoglobulins led to complete neurological recovery and tumor regression.
authors.affiliation: Department of Internal Medicine, UPMC, McKeesport, PA, USA.
authors.forename: Sajid
authors.initials: S
authors.lastname: Naveed
authors.forename: Kelechi
authors.initials: K
authors.lastname: Okoli
authors.forename: Jocelyn
authors.initials: J
authors.lastname: Hollingsworth
authors.forename: Rahil
authors.initials: R
authors.lastname: Kasmani
mesh_terms: D000368:Aged; D018288:Carcinoma, Small Cell / Q000150:complications* / Q000175:diagnosis; D020275:Guillain-Barre Syndrome / Q000209:etiology*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000175:diagnosis; D008297:Male; D010257:Paraneoplastic Syndromes / Q000150:complications*; D014057:Tomography, X-Ray Computed