Femtomolar detection of 2,4-dichlorophenoxyacetic acid herbicides via competitive immunoassays using microfluidic based carbon nanotube liquid gated transistor.
Monitoring of environmental pollutants has become increasingly important due to concern over potential health and environmental impact inflicted by these chemicals. In this contribution, we focus on the development of an all-plastic biosensor comprising laminated single-walled carbon nanotubes as the active element and its conductance modulation in a liquid-gated field effect transistor, as the principle of transduction, for the detection of 2,4-dicholorophenoxy acetic acid (2,4-D) herbicide. The reported biosensor is capable of performing real-time label-free detection of analytes in liquid environment. This biosensor which relies on immunoassay principle for specificity is able to detect down to 500 fM levels of 2,4-D in soil samples.
Wijaya
I Putu Mahendra
IP
School of Material Science & Engineering, Nanyang Technological University, Singapore, 639798, Singapore.
Nie
Tey Ju
TJ
Gandhi
Sonu
S
Boro
Robin
R
Palaniappan
Alagappan
A
Hau
Goh Wei
GW
Rodriguez
Isabel
I
Suri
C Raman
CR
Mhaisalkar
Subodh G
SG
D015084:2,4-Dichlorophenoxyacetic Acid / Q000032:analysis*; D004784:Environmental Monitoring / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006540:Herbicides / Q000032:analysis*; D007118:Immunoassay / Q000295:instrumentation*; D008832:Microchemistry / Q000295:instrumentation; D044085:Microfluidics / Q000295:instrumentation*; D036103:Nanotechnology / Q000295:instrumentation; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012989:Soil Pollutants / Q000032:analysis*; D012996:Solutions / Q000737:chemistry; D014173:Transistors, Electronic
D006540:Herbicides; D037742:Nanotubes, Carbon; D012989:Soil Pollutants; D012996:Solutions; D015084:2,4-Dichlorophenoxyacetic Acid