title: Acute variceal bleeding in a patient with idiopathic myelofibrosis successfully treated with endoscopic variceal band ligation and chemotherapy: a case report.
abstract: BACKGROUND
  Idiopathic myelofibrosis is a chronic myeloproliferative disorder characterized by leukoerythroblastosis, massive splenomegaly, and increases in the reticular and collagen fibers in the bone marrow. Portal hypertension is observed in some patients with idiopathic myelofibrosis. Gastrointestinal hemorrhages, which are due mostly to the rupture of the esophageal varices, have been sporadically reported to be an infrequent complication of idiopathic myelofibrosis.
  
  
  METHODS
  We report a case of a Japanese 63-year-old woman with myelofibrosis and variceal hemorrhage, with a background of concomitant portal and pulmonary hypertension. She was successfully treated through a combination of endoscopic variceal ligation and chemotherapy.
  
  
  CONCLUSIONS
  This is the first known report on the successful application of endoscopic variceal ligation and chemotherapy as the therapeutic procedure for an esophageal variceal hemorrhage in a patient with myelofibrosis.
authors.affiliation: Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-Ku, Tokyo, 113-8421, Japan. mootaka@juntendo.ac.jp.
authors.forename: Kumiko
authors.initials: K
authors.lastname: Tamaki
authors.forename: Michiro
authors.initials: M
authors.lastname: Otaka
authors.forename: Naoto
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Kenshi
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Shunhei
authors.initials: S
authors.lastname: Yamashina
authors.forename: Sumio
authors.initials: S
authors.lastname: Watanabe