title: [Adult case of severe Henoch-Schönlein purpura associated with steroid-resistant nephrotic syndrome successfully treated with intravenous cyclophosphamide].
abstract: Henoch-Schönlein purpura (HSP) is a systemic disorder characterized by small vessel vasculitis with the deposition of IgA immune complexes. Renal involvement is the major cause of morbidity and mortality in patients with HSP. We report here a 37-year-old female patient with HSP nephritis (HSPN) associated with steroid-resistant nephrotic syndrome and renal dysfunction despite conventional therapy. The patient was successfully treated with intravenous cyclophosphamide following treatment with intravenous pulse methylprednisolone and oral prednisolone. The combination therapy resulted in a significant decrease in proteinuria, together with improvement of renal function. The patient finally reached a stage of clinical remission.
authors.affiliation: Division of Nephrology, Osaka Rosai Hospital, Osaka, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Namba
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Jun
authors.initials: J
authors.lastname: Matsuda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kadoya
authors.forename: Masanobu
authors.initials: M
authors.lastname: Takeji
authors.forename: Atsushi
authors.initials: A
authors.lastname: Yamauchi
mesh_terms: D000328:Adult; D000936:Antigen-Antibody Complex / Q000378:metabolism; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004351:Drug Resistance; D005260:Female; D005920:Glomerular Mesangium / Q000378:metabolism; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications* / Q000188:drug therapy*; D007070:Immunoglobulin A / Q000378:metabolism; D007262:Infusions, Intravenous; D008775:Methylprednisolone / Q000008:administration & dosage; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000209:etiology*; D011239:Prednisolone / Q000008:administration & dosage; D011507:Proteinuria / Q000188:drug therapy / Q000209:etiology; D020551:Pulse Therapy, Drug; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D003520:Cyclophosphamide; D011239:Prednisolone; D008775:Methylprednisolone