title: Cushing's syndrome and adrenal insufficiency after intradermal triamcinolone acetonide for keloid scars.
abstract: A 6-year-old girl was admitted to our hospital for excessive weight gain. On presentation, she had a typical Cushingoid appearance and hypertension. Laboratory analysis was indicative for an exogenous glucocorticoid source, showing values that were low for serum cortisol and adrenocorticotropin and for 24-h urinary glucocorticoid (metabolite) excretion. Five and 2 months before presentation, she was treated with intradermal triamcinolone acetonide for keloid scars. Recovery of intrinsic cortisol production occurred 12 months after the last steroid dose. Intradermal triamcinolone acetonide for keloid scars in children should be used with care taking into account the here reported complication.
authors.affiliation: Department of Pediatrics, Leiden University Medical Center, PO Box 9600, 2300 RC Leiden, The Netherlands. m.finken@vumc.nl
authors.forename: Martijn J J
authors.initials: MJ
authors.lastname: Finken
authors.forename: Dick
authors.initials: D
authors.lastname: Mul
mesh_terms: D000309:Adrenal Insufficiency / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D000324:Adrenocorticotropic Hormone / Q000097:blood; D002648:Child; D003480:Cushing Syndrome / Q000097:blood / Q000139:chemically induced* / Q000503:physiopathology; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000139:chemically induced; D007271:Injections, Intradermal; D007627:Keloid / Q000188:drug therapy*; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D005938:Glucocorticoids; D000324:Adrenocorticotropic Hormone; D014222:Triamcinolone Acetonide; D006854:Hydrocortisone