title: Reproduction after breast cancer.
abstract: Breast cancer is the most frequently occurring cancer in women of developed countries, and as a result of new developments in breast cancer treatment, more women are cured after being diagnosed with this disease. It is important that fertility preservation strategies are addressed before chemotherapy, because chemotherapy may induce premature ovarian failure (depending on the woman's age, the drugs used, the dosage and duration of treatment). Among possible solutions are embryos or oocytes cryopreservation, ovarian tissue cryopreservation-freezing with a subsequent orthotopic and heterotopic autotransplantation, whole ovary cryopreservation, ovarian suppression with gonadotropin-releasing hormone (GnRH) analogues, which inhibit ovarian follicular depletion induced by chemotherapeutic agents and in vitro fertilisation (IVF) after ovulation induction with aromatase inhibitors or tamoxifen.
authors.affiliation: University of Medicine and Pharmacy, C. Davila, Bucharest, Romania.
authors.forename: Stefanos
authors.initials: S
authors.lastname: Zervoudis
authors.forename: George
authors.initials: G
authors.lastname: Iatrakis
authors.forename: Iordanis
authors.initials: I
authors.lastname: Navrozoglou
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001943:Breast Neoplasms / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy*; D015925:Cryopreservation / Q000379:methods; D004359:Drug Therapy, Combination; D004624:Embryo Transfer; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D005307:Fertilization in Vitro; D014943:Global Health; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000139:chemically induced / Q000188:drug therapy; D010053:Ovary / Q000637:transplantation; D010062:Ovulation Induction; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D012098:Reproduction / Q000187:drug effects*; D012383:Romania / Q000453:epidemiology; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use; D013629:Tamoxifen / Q000627:therapeutic use
chemical_list: D005300:Fertility Agents, Female; D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen; D007987:Gonadotropin-Releasing Hormone