Syntheses of protoporphyrin-IX derivatives bearing extended propionate side-chains.
In order to investigate the relationship between depth within membranes of singlet oxygen generation and effectiveness of photodynamic therapy of tumors, analogs of protoporphyrin-IX 1 bearing five 4 and seven 5 carbon atoms (in place of the 3-carbon atom chain in 1) were synthesized from monopyrrole precursors.
Holmes
Robert T
RT
Lu
Jianming
J
Mwakwari
Celinah
C
Smith
Kevin M
KM