[Rol of pituitary tumour-transforming gene (PTTG) in the pituitary adenomas].
The pathogenesis of pituitary tumours is far to be understood. Pituitary transforming tumour gene (PTTG), a gen that induces aneuploidy, genetic instability, cellular proliferation and to stimulate angiogenesis, has been involved in neoplasic transformation and shown overexpressed in many neoplasm as lung, breast, endometrium, thyroid and colon malignant tumours. On the other hand, PTTG has been inconsistently studied in pituitary tumours. The majority of studies have been performed in animals and there is a great variability in the methods used in its determination. The goal of this review is to resume the role of PTTG in tumourogenesis and critically to revise the studies published in humans in order to advance in the knowledge of the pathogenesis of pituitary adenomas and to find clinical useful predictors of the behavior of these tumours.
Sánchez-Ortiga
Ruth
R
Sección de Endocrinología y Nutrición, Hospital General Universitario de Alicante, Alicante, España.
Sánchez Tejada
Laura
L
Peiró Cabrera
Gloria
G
Moreno-Pérez
Oscar
O
Arias Mendoza
Nieves
N
Aranda López
F Ignacio
FI
Picó Alfonso
Antonio
A
D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics*; D010911:Pituitary Neoplasms / Q000235:genetics*; D064249:Securin
D009363:Neoplasm Proteins; D064249:Securin; C578002:pituitary tumor-transforming protein 1, human