title: No excess risk of follicular lymphoma in kidney transplant and HIV-related immunodeficiency.
abstract: Subtype-specific incidence patterns in populations at high risk of lymphoma offer insight into lymphomagenesis. The incidence profiles for the 2 most common non-Hodgkin lymphoma subtypes were compared for 2 immunodeficient populations, adults receiving a kidney transplant 1982-2003 (n = 7,730) or diagnosed with human immunodeficiency virus (HIV) infection 1982-2004 (n = 17,175). National, population-based registries were linked and standardized incidence ratios (SIRs) were computed for each cohort and lymphoma subtype. Risk of diffuse large B-cell lymphoma was significantly increased after transplantation (SIR 17.83, 95% CI: 13.61-22.95) and after HIV infection (SIR 58.81, 95% CI: 52.59-65.56). Rates of follicular lymphoma (FL) were neither significantly increased nor decreased in transplant recipients (SIR 0.82, 95% CI: 0.10-2.96) and in people with HIV (SIR 1.25, 95% CI: 0.41-2.91). The findings argue against an infectious or other immunodeficiency-related etiology for FL and clearly differentiate it from diffuse large B-cell lymphoma.
authors.affiliation: UNSW Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia. claire.vajdic@unsw.edu.au
authors.forename: Claire M
authors.initials: CM
authors.lastname: Vajdic
authors.forename: Marina T
authors.initials: MT
authors.lastname: van Leeuwen
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Turner
authors.forename: Ann M
authors.initials: AM
authors.lastname: McDonald
authors.forename: Angela C
authors.initials: AC
authors.lastname: Webster
authors.forename: Stephen P
authors.initials: SP
authors.lastname: McDonald
authors.forename: Jeremy R
authors.initials: JR
authors.lastname: Chapman
authors.forename: John M
authors.initials: JM
authors.lastname: Kaldor
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Grulich
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001315:Australia / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000276:immunology; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation / Q000276:immunology / Q000706:statistics & numerical data*; D016483:Lymphoma, AIDS-Related / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D008224:Lymphoma, Follicular / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D008297:Male; D008875:Middle Aged; D009520:New Zealand / Q000453:epidemiology; D055815:Young Adult