title: Transcriptome of normal lung distinguishes mouse lines with different susceptibility to inflammation and to lung tumorigenesis.
abstract: AIRmax and AIRmin mouse lines show a differential lung inflammatory response and differential lung tumor susceptibility after urethane treatment. The transcript profile of approximately 24,000 known genes was analyzed in normal lung tissue of untreated and urethane-treated AIRmax and AIRmin mice. In lungs of untreated mice, inflammation-associated genes involved in pathways such as "leukocyte transendothelial migration", "cell adhesion" and "tight junctions" were differentially expressed. Moreover, gene expression levels differed significantly in urethane-treated mice; in AIRmin mice, modulation of expression of genes involved in pathways associated with inflammatory response paralleled the previously observed persistent infiltration of inflammatory cells in the lung of these mice.
authors.affiliation: Laboratory of Imunogenetics, Instituto Butantan, Avenida Dr. Vital Brazil, 1500, 05503-900, São Paulo, Brazil.
authors.forename: Marcelo De
authors.initials: MD
authors.lastname: Franco
authors.forename: Francesca
authors.initials: F
authors.lastname: Colombo
authors.forename: Antonella
authors.initials: A
authors.lastname: Galvan
authors.forename: Loris De
authors.initials: LD
authors.lastname: Cecco
authors.forename: Elena
authors.initials: E
authors.lastname: Spada
authors.forename: Silvano
authors.initials: S
authors.lastname: Milani
authors.forename: Olga M
authors.initials: OM
authors.lastname: Ibanez
authors.forename: Tommaso A
authors.initials: TA
authors.lastname: Dragani
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D006801:Humans; D008168:Lung / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology; D008297:Male; D051379:Mice; D011014:Pneumonia / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology; D014520:Urethane
chemical_list: D014520:Urethane