title: Efficient Organocatalytic alpha-Sulfenylation of Substituted Piperazine-2,5-diones.
abstract: Organocatalytic alpha-sulfenylation of substituted piperazine-2,5-diones is reported through the use of cinchona alkaloids as Lewis bases and electrophilic sulfur transfer reagents. 1-Phenylsulfanyl[1,2,4]triazole, a novel sulfur transfer reagent, gave excellent product yields with a number of substituted piperazine-2,5-diones under mild conditions. Catalyst loading, stoichiometry of sulfur electrophile, temperature and solvent were optimized to achieve high product yields.
authors.affiliation: Department of Chemistry, The University of Arizona, Tucson, AZ 85721.
authors.forename: Ramin
authors.initials: R
authors.lastname: Dubey
authors.forename: Nathan W
authors.initials: NW
authors.lastname: Polaske
authors.forename: Gary S
authors.initials: GS
authors.lastname: Nichol
authors.forename: Bogdan
authors.initials: B
authors.lastname: Olenyuk