Two new cytotoxic cardenolides from the latex of Antiaris toxicaria.
Two new cardenolides, toxicarioside F (1) and toxicarioside G (2), were isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Their structures were elucidated on the basis of spectral data and chemical evidence. Compounds 1 and 2 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by the MTT method.
Dai
Hao-Fu
HF
Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China.
Gan
Yu-Juan
YJ
Que
Dong-Mei
DM
Wu
Jiao
J
Wen
Zhen-Chang
ZC
Mei
Wen-Li
WL
D031621:Antiaris / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002301:Cardiac Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells; D007840:Latex / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D002301:Cardiac Glycosides; D004365:Drugs, Chinese Herbal; D007840:Latex; C548599:toxicarioside F; C548600:toxicarioside G