title: Intracranial hemorrhage following neuroendovascular procedures with abciximab is associated with high mortality: a multicenter series.
abstract: BACKGROUND
  Abciximab is being used as an adjunct to neuroendovascular procedures both to prevent and treat ischemic sequelae. Experience with abciximab in this setting is limited; major bleeding complications, including fatal intracranial hemorrhage (ICH), are of particular concern. We report our multicenter experience with ICH following the administration of abciximab during neuroendovascular procedures.
  
  
  METHODS
  We identified neuroendovascular procedures (including cerebral angiograms, aneurysm coiling procedures, angioplasty/vascular stenting procedures, and emergent revascularization procedures) that used abciximab at Mayo Clinic Hospitals in Rochester, Jacksonville, and Phoenix between November 2000 and April 2009. Cases of periprocedural ICH were identified and pertinent demographic, historical, procedural, radiographic, and laboratory data were collected. Clinical outcome was measured either at death or discharge by the Glasgow Outcome Scale (GOS).
  
  
  RESULTS
  Abciximab was used in 51 neuroendovascular procedures; 9 cases of ICH were identified. Procedures performed and indications for abciximab use varied. Route of abciximab administration included IV bolus only (n = 4), IA bolus followed by IV infusion (n = 3), IV bolus followed by IV infusion (n = 1), and IV infusion without preceding bolus (n = 1). All but 1 of the patients received concomitant periprocedural antiplatelet, anticoagulant, or thrombolytic agents. Eight of the 9 cases of ICH were detected within 7 h of abciximab administration. ICH pattern varied. Four patients died following ICH.
  
  
  CONCLUSIONS
  Adjunctive use of abciximab to prevent or treat ischemic sequelae during neuroendovascular procedures is associated with a high risk of ICH (18%). We report 9 cases of ICH associated with abciximab administration during neuroendovascular procedures with 44% mortality.
authors.affiliation: Department of Neurology, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA.
authors.forename: Ryan D
authors.initials: RD
authors.lastname: Walsh
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Barrett
authors.forename: Maria I
authors.initials: MI
authors.lastname: Aguilar
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Lanzino
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Hanel
authors.forename: David A
authors.initials: DA
authors.lastname: Miller
authors.forename: Brian W
authors.initials: BW
authors.lastname: Chong
authors.forename: W David
authors.initials: WD
authors.lastname: Freeman
mesh_terms: D000077284:Abciximab; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D057510:Endovascular Procedures / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000627:therapeutic use*; D020300:Intracranial Hemorrhages / Q000209:etiology / Q000401:mortality* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D010975:Platelet Aggregation Inhibitors; D000077284:Abciximab