title: Successful allogeneic bone marrow transplantation for diamond-blackfan anemia complicated by severe cardiac dysfunction due to transfusion-induced hemochromatosis.
abstract: A 21-year-old man who was diagnosed with Diamond-Blackfan anemia at 2 years of age came to our hospital with the hope of undergoing bone marrow transplantation (BMT). He had been red cell transfusion-dependent for about 8 years; at presentation he had transfusion-induced hemochromatosis, a subsequent low left ventricular ejection fraction (LVEF) of 43%, and diabetes mellitus requiring insulin therapy. He received unrelated BMT with reduced intensity conditioning and sufficient GVHD prophylaxis. Regardless of the cardiac dysfunction, he had an uneventful course during pre- and post-grafting periods, and is currently doing well with an improved LVEF (55%), although he is still insulin dependent.
authors.affiliation: Department of Hematology and Clinical Immunology, Kobe City Medical Center General Hospital.
authors.forename: Sumie
authors.initials: S
authors.lastname: Tabata
authors.forename: Minako
authors.initials: M
authors.lastname: Mori
authors.forename: Yuya
authors.initials: Y
authors.lastname: Nagai
authors.forename: Hisako
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Arima
authors.forename: Seiji
authors.initials: S
authors.lastname: Nagano
authors.forename: Yoko
authors.initials: Y
authors.lastname: Takiuchi
authors.forename: Daichi
authors.initials: D
authors.lastname: Inoue
authors.forename: Takaharu
authors.initials: T
authors.lastname: Kimura
authors.forename: Sonoko
authors.initials: S
authors.lastname: Shimoji
authors.forename: Soshi
authors.initials: S
authors.lastname: Yanagita
authors.forename: Kiminari
authors.initials: K
authors.lastname: Ito
authors.forename: Akiko
authors.initials: A
authors.lastname: Matsushita
authors.forename: Kenichi
authors.initials: K
authors.lastname: Nagai
authors.forename: Takayuki
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D029503:Anemia, Diamond-Blackfan / Q000628:therapy*; D016026:Bone Marrow Transplantation; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000209:etiology; D006432:Hemochromatosis / Q000150:complications* / Q000209:etiology; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D065227:Transfusion Reaction; D014184:Transplantation, Homologous; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology*; D055815:Young Adult
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin