title: Ethacrynic acid analogues lacking the alpha,beta-unsaturated carbonyl unit--potential anti-metastatic drugs.
abstract: A series of ethacrynic acid analogues, lacking the alpha,beta-unsaturated carbonyl unit, was synthesized and subsequently evaluated for their ability to inhibit the migration of human breast cancer cells, MCF-7/AZ. Several of the analogues were already active in the low micromolar range, whereas ethacrynic acid itself shows no potential to inhibit the migration of these cancer cells. Preliminary studies show that the presence of one or more methoxy groups at the phenyl ring of ethacrynic acid is important in order for the ethacrynic acid analogues to demonstrate an inhibitory effect on the migration.
authors.affiliation: Laboratory of Organic Synthesis, Catalysis and Biochemistry (LOSCB), Department of Chemistry, New Mexico Institute of Mining and Technology, Socorro, NM 87801, USA.
authors.forename: Romy F J
authors.initials: RF
authors.lastname: Janser
authors.forename: Ranjith K
authors.initials: RK
authors.lastname: Meka
authors.forename: Zack E
authors.initials: ZE
authors.lastname: Bryant
authors.forename: Enoch A
authors.initials: EA
authors.lastname: Adogla
authors.forename: Elizabeth K
authors.initials: EK
authors.lastname: Vogel
authors.forename: Jaimie L
authors.initials: JL
authors.lastname: Wharton
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Tilley
authors.forename: Catherine N
authors.initials: CN
authors.lastname: Kaminski
authors.forename: Seth L
authors.initials: SL
authors.lastname: Ferrey
authors.forename: Severine
authors.initials: S
authors.lastname: Van Slambrouck
authors.forename: Wim F A
authors.initials: WF
authors.lastname: Steelant
authors.forename: Ingo
authors.initials: I
authors.lastname: Janser
mesh_terms: D045744:Cell Line, Tumor; D004976:Ethacrynic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D009362:Neoplasm Metastasis / Q000517:prevention & control*
chemical_list: D004976:Ethacrynic Acid