Asymmetric Synthesis of the Core of AMPTD, the Key Amino Acid of Microsclerodermins F-I.
We report a stereoselective synthesis of the five consecutive stereocenters of AMPTD in seven steps. Highlights include an Evans glycolate aldol reaction, the use of a Weinreb amide as an aldehyde masking group, and a Mannich reaction with an Ellman-type chiral sulfimine.
Burnett
Cameron M
CM
Department of Chemistry, Colorado State University, Fort Collins, CO 80523, USA.
Williams
Robert M
RM