title: Global regulation by the seven-component Pi signaling system.
abstract: This review concerns how Escherichia coli detects environmental inorganic orthophosphate (P(i)) to regulate genes of the phosphate (Pho) regulon by the PhoR/PhoB two-component system (TCS). P(i) control by the PhoR/PhoB TCS is a paradigm of a bacterial signal transduction pathway in which occupancy of a cell surface receptor(s) controls gene expression in the cytoplasm. The P(i) signaling pathway requires seven proteins, all of which probably interact in a membrane-associated signaling complex. Our latest studies show that P(i) signaling involves three distinct processes, which appear to correspond to different states of the sensory histidine kinase PhoR: an inhibition state, an activation state, and a deactivation state. We describe a revised model for P(i) signal transduction of the E. coli Pho regulon.
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA. yhsieh@purdue.edu
authors.forename: Yi-Ju
authors.initials: YJ
authors.lastname: Hsieh
authors.forename: Barry L
authors.initials: BL
authors.lastname: Wanner
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial; D010710:Phosphates / Q000378:metabolism*; D018085:Regulon; D015398:Signal Transduction
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D010710:Phosphates; C061278:PhoB protein, Bacteria; C061279:PhoR protein, Bacteria