title: Hyaluronic acid binding and acrosin activity are decreased in sperm from men with spinal cord injury.
abstract: In this study, acrosin activity and hyaluronic acid binding were compared in sperm from men with spinal cord injury versus sperm from healthy controls. The results showed statistically significantly lower acrosin activity and statistically significantly lower hyaluronic acid binding in spinal cord injured patients compared with controls, indicating functional impairments that may diminish the capacity of the sperm to fertilize oocytes.
authors.affiliation: The Miami Project to Cure Paralysis, Department of Urology, University of Miami Miller School of Medicine, Miami, Florida, USA.
authors.forename: Viacheslav
authors.initials: V
authors.lastname: Iremashvili
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Brackett
authors.forename: Emad
authors.initials: E
authors.lastname: Ibrahim
authors.forename: Teodoro C
authors.initials: TC
authors.lastname: Aballa
authors.forename: Darren
authors.initials: D
authors.lastname: Bruck
authors.forename: Charles M
authors.initials: CM
authors.lastname: Lynne
mesh_terms: D000176:Acrosin / Q000378:metabolism*; D000328:Adult; D016022:Case-Control Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism*; D007248:Infertility, Male / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D013081:Sperm Motility / Q000502:physiology; D013084:Sperm-Ovum Interactions / Q000502:physiology; D013094:Spermatozoa / Q000378:metabolism*; D013119:Spinal Cord Injuries / Q000378:metabolism*
chemical_list: D006820:Hyaluronic Acid; D000176:Acrosin