title: Reduced glutathione decreases energy expenditure in chicks exposed to separation stress.
abstract: Recently, we reported that intracerebroventricular (i.c.v.) injection of reduced glutathione (GSH) induces hypnotic and sedative effects under an acute stressful condition in chicks. However, no information is available on the effects of GSH on energy expenditure (EE) under stressful conditions. The purpose of the present study was to clarify whether i.c.v. injection of GSH affects EE of neonatal chicks, and whether EE is correlated with behavioral changes after isolation-induced stress. The EE was rapidly decreased by i.c.v. injection of GSH, but was increased 27 min after injection. This change in EE was correlated with behavioral changes in which GSH induced hypnotic and sedative effects shortly after injection, followed by a period in which activity increased. The present study demonstrates that central GSH initially causes lowered EE through hypnotic and sedative effects under an acute stressful condition in chicks.
authors.affiliation: Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Higashi, Fukuoka, Japan.
authors.forename: Haruka
authors.initials: H
authors.lastname: Yamane
authors.forename: Shozo
authors.initials: S
authors.lastname: Tomonaga
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Tsuneyoshi
authors.forename: D Michael
authors.initials: DM
authors.lastname: Denbow
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Furuse
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D002552:Cerebral Ventricles; D002645:Chickens / Q000502:physiology*; D004734:Energy Metabolism / Q000187:drug effects*; D005978:Glutathione / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D010084:Oxidation-Reduction; D013315:Stress, Psychological / Q000378:metabolism*
chemical_list: D005978:Glutathione