title: Sex-related differences in the risk factor profile and medications of patients with atrial fibrillation recruited in J-TRACE.
abstract: BACKGROUND
  Clinical characteristics, including risk factors for thromboembolism, and medications differ between men and women with atrial fibrillation (AF) in Western countries. Whether such a difference exists for Japanese patients with AF is unclear, so data from J-TRACE were used to investigate this issue.
  
  
  RESULTS
  A total of 2,892 patients (2,028 men, 864 women; 70.3 years old) with AF were analyzed for the respective prevalences of risk factors and medications. CHADS2 score was calculated to determine thromboembolic risk level. Women were older (P<0.001), and more frequently had heart failure (P<0.001), and hypertension (P=0.051) than men. The proportion of subjects aged 75 years or older was higher among women than among men (P<0.001). CHADS2 score was therefore significantly higher in women than in men (2.05+/-1.29 vs 1.88+/-1.33, P<0.001). Sex-related differences were not observed for the prevalence of diabetes mellitus, myocardial infarction or ischemic stroke, nor did warfarin usage differ between men and women.
  
  
  CONCLUSIONS
  Sex-related differences were observed in the risk factor profile and medications of Japanese patients with AF. CHADS2 score was higher in women than in men.
authors.affiliation: Department of Internal Medicine, University of Toyama, Toyama, Japan. hiroshi@med.u-toyama.ac.jp
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inoue
authors.forename: Takashi
authors.initials: T
authors.lastname: Nozawa
authors.forename: Tadakazu
authors.initials: T
authors.lastname: Hirai
authors.forename: Shinya
authors.initials: S
authors.lastname: Goto
authors.forename: Hideki
authors.initials: H
authors.lastname: Origasa
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Shimada
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Uchiyama
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hirabayashi
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Koretsune
authors.forename: Shiro
authors.initials: S
authors.lastname: Ono
authors.forename: Tooru
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Sasagawa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Kaneko
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ikeda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin; D001281:Atrial Fibrillation / Q000150:complications*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents; D007564:Japan; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors; D055553:Prescription Drugs; D012042:Registries; D012307:Risk Factors; D012727:Sex Characteristics; D013923:Thromboembolism / Q000453:epidemiology* / Q000517:prevention & control; D014859:Warfarin
chemical_list: D007004:Hypoglycemic Agents; D010975:Platelet Aggregation Inhibitors; D055553:Prescription Drugs; D014859:Warfarin; D001241:Aspirin