A new C29-sterol with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge lanthella sp.
One new C(29) sterol with a cyclopropane ring at C-25 and C-26, aragusteroketal B (1), and aragusterol B (2) were isolated from the Vietnamese marine sponge Ianthella sp. Their structures were elucidated by extensive spectroscopic analyses. Both 1 and 2 showed moderate cytotoxic activity against MCF-7, SK-Hep-1, and HeLa cell lines with IC(50) in the range of 12.8-27.8 microM.
Tung
Nguyen Huu
NH
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Vietnam.
Van Minh
Chau
C
Van Kiem
Phan
P
Huong
Hoang Thanh
HT
Ha
Tran Thu
TT
Dat
Nguyen Tien
NT
Nhiem
Nguyen Xuan
NX
Cuong
Nguyen Xuan
NX
Hyun
Jae-Hee
JH
Kang
Hee-Kyoung
HK
Kim
Young Ho
YH
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002852:Chromatography, Ion Exchange; D002855:Chromatography, Thin Layer; D004396:Coloring Agents; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D011161:Porifera / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013261:Sterols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013778:Tetrazolium Salts; D013844:Thiazoles; D014744:Vietnam
D000970:Antineoplastic Agents; D004396:Coloring Agents; D007202:Indicators and Reagents; D013261:Sterols; D013778:Tetrazolium Salts; D013844:Thiazoles; C549416:aragusteroketal B; C022616:thiazolyl blue