Synthesis of temperature-responsive poly(N-isopropyl acrylamide)/poly(methyl methacrylate)/silica hybrid capsules from inverse pickering emulsion polymerization and their application in controlled drug release.
Poly(N-isopropylacrylamide)/poly(methyl methacrylate)/silica hybrid capsules were prepared from inverse Pickering emulsion polymerization. A N-isopropylacrylamide aqueous solution was emulsified into an oil phase containing methyl methacrylate and divinyl benzene by sonication to obtain a W/O Pickering emulsion using modified silica nanoparticles as stabilizers. After the emulsion was polymerized, the hybrid capsules were obtained. The capsule wall contained two layers--a solid particle monolayer and a polymer layer--and the wall thickness could be controlled by adjusting the methyl methacrylate and divinyl benzene concentrations in the continuous oil phase before polymerization. The as-synthesized capsules exhibited temperature-responsive properties. The controlled release experiments showed that the release rate of a model drug from the hybrid capsules could be controlled by adjusting the wall thickness of the capsule or the temperature of the release medium.
Zhang
Kui
K
Key Laboratory for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China.
Wu
Wei
W
Guo
Kai
K
Chen
Jianfeng
J
Zhang
Pengyuan
P
D000178:Acrylamides / Q000737:chemistry*; D000180:Acrylic Resins; D004655:Emulsions; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011108:Polymers / Q000737:chemistry*; D019904:Polymethyl Methacrylate / Q000737:chemistry*; D013696:Temperature
D000178:Acrylamides; D000180:Acrylic Resins; D004655:Emulsions; D004364:Pharmaceutical Preparations; D011108:Polymers; C052970:poly-N-isopropylacrylamide; D019904:Polymethyl Methacrylate