DNA repair: how MutM finds the needle in a haystack.
High-resolution crystal structures of DNA complexes with the bacterial MutM protein show how the enzyme feels its way around the double helix in search of an oxidized guanine before flipping it out into its active site and excising it.
Jiricny
Josef
J
Institute of Molecular Cancer Research, University of Zurich and ETH Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland. jiricny@imcr.uzh.ch
D004247:DNA / Q000378:metabolism*; D004260:DNA Repair / Q000502:physiology*; D043382:DNA-Formamidopyrimidine Glycosylase / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000378:metabolism*; D046911:Macromolecular Substances / Q000378:metabolism*; D008957:Models, Genetic; D009690:Nucleic Acid Conformation
D029968:Escherichia coli Proteins; D046911:Macromolecular Substances; D004247:DNA; D043382:DNA-Formamidopyrimidine Glycosylase; C468610:DNA-formamidopyrimidine glycosylase, E coli