Primary T-cell lymphoma of the thyroid associated with Hashimoto's thyroiditis, histologically mimicking MALT-lymphoma.
Most of thyroid lymphomas are B-lineage, and T-cell lymphomas are rare. Here, we report a case of primary thyroid T-cell lymphoma associated with Hashimoto's thyroiditis. A 48-yr-old woman presented with incidentally found neck mass. Histologically, the resected right lobe of the thyroid was replaced by monomorphic small atypical lymphoid cells with lymphoepithelial lesion-like change, most of which were immunoreactive for CD3, CD8, betaF-1, and TIA-1. Peripheral T-cell lymphoma, unspecified, was finally diagnosed after molecular study for TCR-gamma gene rearrangement. This is the second case of cytotoxic T-cell lymphoma reported in the thyroid gland so far. Unique association between thyroid follicles and neoplastic lymphocytes may be characteristic feature of this type of T-cell lymphoma.
Kim
Na Rae
NR
Department of Pathology, Gachon University of Medicine and Science, Gil Medical Center, Incheon, Korea.
Ko
Young-Hyeh
YH
Lee
Young-Don
YD
D005260:Female; D050031:Hashimoto Disease / Q000473:pathology*; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000473:pathology*; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000473:pathology; D013961:Thyroid Gland / Q000473:pathology*