title: [Clinicopathological analysis of 250 patients with early-stage gastric cancer].
abstract: OBJECTIVE
  To explore the factors associated with early diagnosis of gastric cancer.
  
  
  METHODS
  Clinical data were retrospectively analyzed for 250 patients with early-stage gastric cancer (EGC) from 2005 to 2008, during which the concept of intra-epithelial neoplasia (IN) was adopted in our department.
  
  
  RESULTS
  On preoperative endoscopic biopsy with pathological exam, there were 15 cases suspicious for cancer, 90 with high-grade IN (HGIN), and 15 gastric cancer. Postoperative pathological exam of the surgical specimen showed infiltrating early-stage cancer in 224 patients, of which 5 (2.2%) were type I (all were Tsm), 190 (84.8%) were type II including Tm in 82 and Tsm in 108 patients, 29 were type III (5 Tm and 24 Tsm). Twenty-six patients had non-infiltrating lesions (Tis). There were 184 (73.6%) well-differentiated tumors, including 26 Tis, 58 Tm, and 100 Tsm. Lymphatic metastasis was identified in 21 patients, of which 2 (2.3%) were Tm (all were poorly-differentiated) and 19 (13.9%) were Tsm. Lymphadenopathy was present in 15 (7.9%) cases in type II, and in 6 (20.7%) in type III. Of the 90 cases with a preoperative diagnosis of HGIN, 24 were found to be Tis, 29 were Tm, and 37 were Tsm on postoperative pathological assessment.
  
  
  CONCLUSIONS
  Well-differentiation is the main histological type in EGC. The adoption of the concept of IN is associated with improved detection of EGC, which warrants further investigation.
authors.affiliation: Department of Pathology, Affiliated Jiangyin Hospital, Medical College of Southeast University, Jiangsu, Jiangyin, China.
authors.forename: Jian-zhong
authors.initials: JZ
authors.lastname: Qian
authors.forename: Ke
authors.initials: K
authors.lastname: Zhao
authors.forename: Shi-lan
authors.initials: SL
authors.lastname: Li
authors.forename: Hong-ming
authors.initials: HM
authors.lastname: Xu
mesh_terms: D002278:Carcinoma in Situ / Q000473:pathology*; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology*