title: Use of normal tissue complication probability models in the clinic.
abstract: The Quantitative Analysis of Normal Tissue Effects in the Clinic (QUANTEC) review summarizes the currently available three-dimensional dose/volume/outcome data to update and refine the normal tissue dose/volume tolerance guidelines provided by the classic Emami et al. paper published in 1991. A "clinician's view" on using the QUANTEC information in a responsible manner is presented along with a description of the most commonly used normal tissue complication probability (NTCP) models. A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included.
authors.affiliation: Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27514, USA. marks@med.unc.edu
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Marks
authors.forename: Ellen D
authors.initials: ED
authors.lastname: Yorke
authors.forename: Andrew
authors.initials: A
authors.lastname: Jackson
authors.forename: Randall K
authors.initials: RK
authors.lastname: Ten Haken
authors.forename: Louis S
authors.initials: LS
authors.lastname: Constine
authors.forename: Avraham
authors.initials: A
authors.lastname: Eisbruch
authors.forename: Søren M
authors.initials: SM
authors.lastname: Bentzen
authors.forename: Jiho
authors.initials: J
authors.lastname: Nam
authors.forename: Joseph O
authors.initials: JO
authors.lastname: Deasy
mesh_terms: D000328:Adult; D002648:Child; D019583:Dose Fractionation, Radiation; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008954:Models, Biological; D015233:Models, Statistical; D009928:Organ Specificity; D017410:Practice Guidelines as Topic; D011832:Radiation Injuries / Q000517:prevention & control*; D018787:Radiation Oncology; D011836:Radiation Tolerance