Conjunctivally administered NGF antibody reduces pain sensitivity and anxiety-like behavioral responses in aged female mice.
This study reports that peripheral administration of Nerve Growth Factor antibodies (ANA) affects behavior in aged female CD-1 mice. ANA increased the propensity of mice to stay and perform behaviors in the anxiogenic open arms of the maze, lowered pain sensitivity and reduced behavioral flexibility in a Morris water maze task, also reducing ChAT immunoreactivity in the basal forebrain. These findings support the hypothesis that topical eye application can represent an alternative route for delivering biologically active compounds into the brain allowing studying the role of NGF on brain cell function.
Berry
Alessandra
A
Department of Cell Biology and Neurosciences, Istituto Superiore di Sanità, Rome, Italy.
Aloe
Luigi
L
Rossi
Simona
S
Bonsignore
Luca T
LT
Capone
Francesca
F
Alleva
Enrico
E
Cirulli
Francesca
F
D000375:Aging; D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004195:Disease Models, Animal; D004597:Electroshock / Q000009:adverse effects; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D018782:Maze Learning / Q000187:drug effects; D051379:Mice; D020932:Nerve Growth Factor / Q000276:immunology*; D017288:Pain Threshold / Q000187:drug effects*
D000906:Antibodies; D020932:Nerve Growth Factor; D002795:Choline O-Acetyltransferase