title: Interpenetrating network hydrogel beads of carboxymethylcellulose and egg albumin for controlled release of lipid lowering drug.
abstract: Novel interpenetrating network hydrogel beads of sodium carboxymethylcellulose and egg albumin loaded with a lipid lowering drug, simvastatin, were prepared by ionotropic gelation and covalent cross-linking method. The IPN beads were characterized by differential scanning colorimetric analysis, X-ray diffractometry to understand the crystalline nature of the drug after entrapment into IPN matrix. Fourier transform infrared spectroscopy was used to find the chemical stability of drug in the polymer matrix and scanning electron microscopy was performed to study the surface morphology. The ionically cross-linked beads were capable of releasing drug up to 7 h, whereas the drug release was extended up to 12 h in case of dual cross-linked beads. The beads which were prepared with higher concentration of glutaraldehyde released the drug more slowly. The release data were fitted to an empirical equation to determine the transport mechanism, which indicated the non-Fickian trend for drug transport.
authors.affiliation: Department of Pharmaceutics, BLDEA's College of Pharmacy, Bijapur, India.
authors.forename: Rashmi
authors.initials: R
authors.lastname: Boppana
authors.forename: Raghavendra V
authors.initials: RV
authors.lastname: Kulkarni
authors.forename: Srinivas S
authors.initials: SS
authors.lastname: Mutalik
authors.forename: C Mallikarjun
authors.initials: CM
authors.lastname: Setty
authors.forename: Biswanath
authors.initials: B
authors.lastname: Sa
mesh_terms: D000418:Albumins / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D003692:Delayed-Action Preparations; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D000960:Hypolipidemic Agents / Q000008:administration & dosage; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D015394:Molecular Structure; D019821:Simvastatin / Q000008:administration & dosage; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000418:Albumins; D003692:Delayed-Action Preparations; D000960:Hypolipidemic Agents; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D019821:Simvastatin; D002266:Carboxymethylcellulose Sodium