title: [Recurrence in operated patients with laryngeal squamous cell carcinoma].
abstract: OBJECTIVE
  The aim of the present study was to investigate the recurrence prevalence in patients with laryngeal squamous cell carcinoma (LSCC) underwent surgery as primary treatment.
  
  
  METHODS
  The assessed group consisted of 148 patients with operable LSCC underwent surgery as primary treatment between 1999-2002. Surgery was performed in all cases. Total laryngectomy was performed in 107 (72.3%) patients and laser endoscopic tumor resection was performed in 41 (27.7%) patients.
  
  
  RESULTS
  Local recurrence occurred in 18 (12.2%) patients, nodal recurrence in 12 (8.1%) and both and/or remote metastases in 6 (4%) patients. Altogether, recurrence was present in 36 (24.3%) patients and 111 (75.7%) patients had no symptoms of recurrence. Recurrence prevalence in 3-year follow-up--prevalence of recurrence significantly increased with tumor's T feature (p=0.04), N feature (p=0.03), progression of clinical stage (p=0.008) and histological malignancy G stage (p=0.01). Recurrence prevalence in 5-year follow-up--prevalence of recurrence significantly increased with tumor's T feature (p=0.02), N feature (p=0.01), progression of clinical stage (p=0.003) and histological malignancy G stage (p=0.002). Tumors localized in glottic area had less recurrences than those localized in supraglottic area (p=0.05). There were no significant dependence between recurrence type (local or nodal) and tumor's clinicopathological features. Multiple factor analysis with logistic regression model did not revealed simultaneous influence of many variables on recurrence's presence and type. Using multiple factor analysis with Cox's regression model it was proved that recurrence presence (p<0.00001) is a significant independent prognostic factor in the analyzed group of patients with laryngeal carcinoma in 3-year follow-up.
  
  
  CONCLUSIONS
  Recurrence prevalence depends on localization, systemic progression stage, clinical progression stage, cervical lymph nodes state and histological malignancy stage of tumor. Patients with local recurrence have statistically significantly worse prognosis than patients with no recurrence. Recurrence presence is significant independent prognostic factor in 3-year follow-up.
authors.affiliation: Klinika Otolaryngologii i Onkologii, Laryngologicznej Uniwersytetu Medycznego w Lublinie. kamal1@op.pl
authors.forename: Kamal
authors.initials: K
authors.lastname: Morshed
authors.forename: Marcin
authors.initials: M
authors.lastname: Szymański
authors.forename: Marek
authors.initials: M
authors.lastname: Zadrozniak
authors.forename: Henryk
authors.initials: H
authors.lastname: Siwiec
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Wawrzecka
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Tarasiuk
authors.forename: Rashad
authors.initials: R
authors.lastname: Abushammalah
authors.forename: Agata
authors.initials: A
authors.lastname: Smoleń
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000601:surgery*; D018450:Disease Progression; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000453:epidemiology* / Q000601:surgery*; D007825:Laryngectomy / Q000706:statistics & numerical data; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology* / Q000601:surgery*; D009367:Neoplasm Staging; D011044:Poland / Q000453:epidemiology; D015995:Prevalence; D011379:Prognosis; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors