title: Three novel terpenoids from the rhizomes of Curcuma longa.
abstract: Investigation of the EtOH extract of the rhizomes of Curcuma longa led to the isolation of two new sesquiterpenes, 2-methoxy-5-hydroxybisabola-3,10-diene-9-one (1) and 2,8-epoxy-5-hydroxybisabola-3,10-diene-9-one (2), one new monoterpene, 2-(2,5-dihydroxy-4-methylcyclohex-3-enyl)propanoic acid (3), together with five known sesquiterpenes (4-8). Among the known compounds, bisacurone A (5) and 4-methylene-5-hydroxybisabola-2,10-diene-9-one (6) were isolated from C. longa and genus Curcuma for the first time, respectively. Their structures were established on the basis of various spectroscopic analyses including HR-ESI-MS, 1D and 2D NMR, IR spectra, and by comparison of their spectral data with those of related compounds.
authors.affiliation: Key Lab of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Jia-Tao
authors.initials: JT
authors.lastname: Feng
authors.forename: Yuan-Sheng
authors.initials: YS
authors.lastname: Xiao
authors.forename: Ya-Qin
authors.initials: YQ
authors.lastname: Wang
authors.forename: Xing-Ya
authors.initials: XY
authors.lastname: Xue
authors.forename: Xin-Miao
authors.initials: XM
authors.lastname: Liang
mesh_terms: D030024:Curcuma / Q000737:chemistry*; D003511:Cyclohexanols / Q000737:chemistry / Q000302:isolation & purification; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D039821:Monoterpenes / Q000737:chemistry / Q000302:isolation & purification*; D019906:Nuclear Magnetic Resonance, Biomolecular; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: C547974:2,8-epoxy-5-hydroxybisabola-3,10-diene-9-one; C547975:2-methoxy-5-hydroxybisabola-3,10-diene-9-one; D003511:Cyclohexanols; D004365:Drugs, Chinese Herbal; D039821:Monoterpenes; D012717:Sesquiterpenes; C531975:bisacurone