title: Cytotoxic germacranolide sesquiterpenes from the bark of Magnolia kobus.
abstract: A new (3) and three known germacrane-type sesquiterpenoids were isolated from the chloroform-soluble fraction of the methanolic extract of the bark of Magnolia kobus (Magnoliaceae) through repeated silica gel and Sephadex LH-20 column chromatography. Their chemical structures were elucidated as costunolide (1), parthenolide (2), isobisparthenolidine (3), and bisparthenolidine (4) by spectroscopic analysis. Compounds 1-4 exhibited cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells.
authors.affiliation: Department of Oriental Alternative Medicine, Nambu University, Gwangju 506-706, Korea.
authors.forename: Hee Wook
authors.initials: HW
authors.lastname: Park
authors.forename: Jae Hyeok
authors.initials: JH
authors.lastname: Lee
authors.forename: Sang-Un
authors.initials: SU
authors.lastname: Choi
authors.forename: Nam-In
authors.initials: NI
authors.lastname: Baek
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Kim
authors.forename: Jae Heon
authors.initials: JH
authors.lastname: Yang
authors.forename: Dae Keun
authors.initials: DK
authors.lastname: Kim
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D031566:Magnolia / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; D045788:Sesquiterpenes, Germacrane; C432449:germacranolide