Long-term efficacy of biofeedback therapy for dyssynergic defecation: randomized controlled trial.
OBJECTIVE
Although biofeedback therapy is effective in the short-term management of dyssynergic defecation, its long-term efficacy is unknown. Our aim was to compare the 1-year outcome of biofeedback (manometric-assisted pelvic relaxation and simulated defecation training) with standard therapy (diet, exercise, laxatives) in patients who completed 3 months of either therapy.


METHODS
Stool diaries, visual analog scales (VASs), colonic transit, anorectal manometry, and balloon expulsion time were assessed at baseline, and at 1 year after each treatment. All subjects were seen at 3-month intervals and received reinforcement. Primary outcome measure (intention-to-treat analysis) was a change in the number of complete spontaneous bowel movements (CSBMs) per week. Secondary outcome measures included bowel symptoms, changes in dyssynergia, and anorectal function.


RESULTS
Of 44 eligible patients with dyssynergic defecation, 26 agreed to participate in the long-term study. All 13 subjects who received biofeedback, and 7 of 13 who received standard therapy, completed 1 year; 6 failed standard therapy. The number of CSBMs per week increased significantly (P<0.001) in the biofeedback group but not in the standard group. Dyssynergia pattern normalized (P<0.001), balloon expulsion time improved (P=0.0009), defecation index increased (P<0.001), and colonic transit time normalized (P=0.01) only in the biofeedback group.


CONCLUSIONS
Biofeedback therapy provided sustained improvement of bowel symptoms and anorectal function in constipated subjects with dyssynergic defecation, whereas standard therapy was largely ineffective.
Rao
Satish S C
SS
Department of Gastroenterology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242-1009, USA. satish-rao@uiowa.edu
Valestin
Jessica
J
Brown
C Kice
CK
Zimmerman
Bridget
B
Schulze
Konrad
K
D001676:Biofeedback, Psychology; D003248:Constipation / Q000503:physiopathology / Q000628:therapy*; D004035:Diet Therapy; D005081:Exercise Therapy; D005260:Female; D005772:Gastrointestinal Transit; D006801:Humans; D054368:Laxatives / Q000627:therapeutic use; D008297:Male; D008365:Manometry; D008875:Middle Aged; D012044:Regression Analysis; D016896:Treatment Outcome
D054368:Laxatives