New insights into fatty liver preservation using Institute Georges Lopez preservation solution.
Institute Georges Lopez preservation solution (IGL-1) has been demonstrated to be useful for fatty liver preservation. The mechanisms responsible for this effective graft protection against ischemia-reperfusion injury are pivotal actions on generation of nitric oxide a diffusible molecule with vasodilator properties, that facilitates the up-regulation of other well-known cytoprotective genes, such as hypoxia-inducible factor-1 alpha (HIF-1alpha) and heme-oxygenase 1 (HO-1). During normoxic reperfusion, the presence of nitric oxide permits HIF-1alpha accumulation to inhibit prolyl-hydoxylases, thus promoting an additional overexpression of the HO-1 in steatotic and nonsteatotic graft livers preserved in IGL-1.
Zaoualí
M A
MA
Instituto de Investigaciones Biomédicas de Barcelona, CSIC-IDIBAPS, Barcelona, Spain. mazbam@iibb.csic.es
Mosbah
I Ben
IB
Abdennebi
H Ben
HB
Calvo
M
M
Boncompagni
E
E
Boillot
O
O
Peralta
C
C
Roselló-Catafau
J
J
D000241:Adenosine / Q000009:adverse effects; D000493:Allopurinol / Q000009:adverse effects; D004903:Erythrocyte Aggregation / Q000187:drug effects; D005234:Fatty Liver / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D005978:Glutathione / Q000009:adverse effects; D051547:Heme Oxygenase-1 / Q000235:genetics; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics; D007328:Insulin / Q000009:adverse effects; D016031:Liver Transplantation / Q000473:pathology*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions / Q000009:adverse effects; D018579:Patient Selection; D011887:Raffinose / Q000009:adverse effects; D015854:Up-Regulation
C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; C504757:IGL-1 solution; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D000493:Allopurinol; D019001:Nitric Oxide Synthase; C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose