MUM1/IRF4: A Review.
MUM1/IRF4 protein is a member of the interferon regulatory factor (IRF) family of transcriptional factors initially described as downstream regulators of interferon signaling. The quantity of this factor varies within the hematopoietic system in a lineage and stage-specific way. It is considered to be a key regulator of several steps in lymphoid, myeloid, and dendritic cell differentiation and maturation. MUM1/IRF4 expression is observed in many lymphoid and myeloid malignancies, and may be a promising target for the treatment of some of these neoplasms. We reviewed the literature on MUM1/IRF4, with emphasis on the pathologic aspects of this marker in reactive and malignant hematologic and nonhematologic conditions.
Gualco
Gabriela
G
Consultoria em Patologia, Botucatu, Sao Paulo, Brazil.
Weiss
Lawrence M
LM
Bacchi
Carlos E
CE
D014408:Biomarkers, Tumor; D006801:Humans; D007150:Immunohistochemistry; D050835:Interferon Regulatory Factors / Q000235:genetics; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000473:pathology; D009101:Multiple Myeloma / Q000235:genetics / Q000473:pathology; D009857:Oncogenes / Q000235:genetics; D000099218:Interferon Regulatory Factor-4
D014408:Biomarkers, Tumor; D050835:Interferon Regulatory Factors; D000099218:Interferon Regulatory Factor-4