Synthesis, Structure and Biological Activity of Amide-Functionalized Titanocenyls: Improving their Cytotoxic Properties.
Nine amide-functionalized titanocenyls have been synthesized and characterized by spectroscopic and analytical methods and the solid state structure of Cp(CpCO-NH-C(6)H(4)-OCF(3))TiCl(2) was determined by single crystal X-ray diffraction. X-ray analysis of Cp(CpCO-NH-C(6)H(4)-OCF(3))TiCl(2) showed that titanium is in a pseudo tetrahedral geometry and contains a Ti-O(amide) coordination. In principle, Ti-O coordination should provide more hydrolytic stability to the corresponding titanocenyls than titanocene dichloride. The cytotoxic activities of these amide-functionalized titanocenyls on HT-29 colon cancer cell line were determined by MTT assay to elucidate structure-activity relationship. All complexes were more cytotoxic than titanocene dichloride and there is no correlation between the para substituents on the phenyl ring and their cytotoxicities.
Gao
Li Ming
LM
Department of Chemistry, University of Puerto Rico, Mayagüez, PR 00681.
Matta
Jaime
J
Rheingold
Arnold L
AL
Meléndez
Enrique
E