South American Heart Transplantation Registry of patients receiving everolimus in their immunosuppressive regimens.
The increasing number of heart transplant recipients receiving immunosuppression with mammalian target of rapamycin inhibitors prompted the implementation of a South American Transplant Physicians Group to register these patients in a database. Everolimus (EVL) is a signal proliferation inhibition that reduces graft vascular disease when used de novo. Recently, its administration has expanded to subjects with resistant rejection or with side effects due to other immunosuppressive drugs (calcineurin inhibitors and/or steroids), allowing for better regulation of the immunosuppressive regimen. Herein we have shown the data collected from patients receiving EVL in ten South American Heart Transplant Centers. We have concluded that the administration of EVL is a useful adjunctive therapy that allows the reduction or suspension of other immunosuppressive drugs that caused unwanted side effects, without a loss of immunosuppressive efficacy, with manageable side effects, and constituting a valuable therapeutic option.
Bortman
G V
GV
Sanatorio Mitre, Buenos Aires, Argentina. gbortman@fibertel.com.ar
Ceruti
B
B
Ahualli
L
L
Colque
R
R
Amuchástegui
M
M
Sgrosso
J L
JL
Muñoz
J
J
Vulcano
N
N
Burgos
C
C
Diez
F
F
Rodriguez
M C
MC
Perrone
S V
SV
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D002648:Child; D016572:Cyclosporine / Q000627:therapeutic use; D000068338:Everolimus; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects / Q000276:immunology* / Q000706:statistics & numerical data*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012042:Registries / Q000706:statistics & numerical data*; D020123:Sirolimus / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013020:South America; D016559:Tacrolimus / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D000068338:Everolimus; D020123:Sirolimus; D016559:Tacrolimus