title: Anticancer mechanism of peptide P18 in human leukemia K562 cells.
abstract: Studies on the anticancer mechanism of peptide P18 in human leukemia K562 cells revealed that P18 causes the death of most K562 cells by depolarizing plasma membrane potential and enhancing membrane permeability, rather than activating the classical apoptosis pathway. The mechanistic studies indicate that disrupting plasma membrane is an effective approach to kill cancer cells and help design more effective peptide analogues in future cancer therapies.
authors.affiliation: Institute for Nanobiomedical Technology and Membrane Biology, West China Hospital, Sichuan University, Chengdu, 610041, China.
authors.forename: Chengkang
authors.initials: C
authors.lastname: Tang
authors.forename: Ximing
authors.initials: X
authors.lastname: Shao
authors.forename: Binbin
authors.initials: B
authors.lastname: Sun
authors.forename: Wenli
authors.initials: W
authors.lastname: Huang
authors.forename: Feng
authors.initials: F
authors.lastname: Qiu
authors.forename: Yongzhu
authors.initials: Y
authors.lastname: Chen
authors.forename: Ying-kang
authors.initials: YK
authors.lastname: Shi
authors.forename: Er-yong
authors.initials: EY
authors.lastname: Zhang
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhao
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016923:Cell Death / Q000187:drug effects; D002463:Cell Membrane Permeability / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020014:K562 Cells; D007938:Leukemia / Q000188:drug therapy*; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D008969:Molecular Sequence Data; D041681:NIH 3T3 Cells
chemical_list: D000903:Antibiotics, Antineoplastic; D023181:Antimicrobial Cationic Peptides; C447608:P18 antimicrobial peptide