title: Transcranial Doppler for brain death in infants: the role of the fontanelles.
abstract: OBJECTIVE
  Transcranial Doppler (TCD) is a sensitive technique for circulatory arrest diagnosis in brain death when patterns such as reverberant flow and short systolic spikes are observed. In infants, the nonossified fontanelles compensate for intracranial hypertension. We describe TCD patterns in infants with brain death, different from adults, with the hemodynamic modifications induced by anterior fontanelle compression.
  
  
  METHODS
  TCD was performed in 2 infants with diagnosed brain death admitted to the neonatal intensive care unit.
  
  
  RESULTS
  TCD showed a large peak 'reverberant' flow, with a high peak systolic velocity and a consistent retrograde component, away from the brain. Compression of the anterior fontanelle induced, at first, a reduction in systolic flow with the subsequent appearance of the characteristic short systolic spikes. Upon compression removal, a brief increase in the systolic flow was observed before the prompt reappearance of the reverberant flow.
  
  
  CONCLUSIONS
  TCD for brain death diagnosis should be done cautiously in infants. In these cases, reverberating flow may be indicative of circulatory arrest even if with a large peak and with a high peak systolic velocity. Heavy fontanelle compression may reproduce the classical adult TCD patterns of brain death, thus supporting the diagnosis of cerebral circulatory arrest.
authors.affiliation: Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy. edoardo.vicenzini@uniromal.it
authors.forename: E
authors.initials: E
authors.lastname: Vicenzini
authors.forename: P
authors.initials: P
authors.lastname: Pulitano
authors.forename: R
authors.initials: R
authors.lastname: Cicchetti
authors.forename: F
authors.initials: F
authors.lastname: Randi
authors.forename: P
authors.initials: P
authors.lastname: Papov
authors.forename: G
authors.initials: G
authors.lastname: Spadetta
authors.forename: G
authors.initials: G
authors.lastname: Sirimarco
authors.forename: M C
authors.initials: MC
authors.lastname: Ricciardi
authors.forename: V
authors.initials: V
authors.lastname: Di Piero
authors.forename: G L
authors.initials: GL
authors.lastname: Lenzi
authors.forename: O
authors.initials: O
authors.lastname: Mecarelli
mesh_terms: D001926:Brain Death / Q000175:diagnosis* / Q000503:physiopathology; D001932:Brain Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D055762:Cranial Fontanelles / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D005910:Glioma / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008297:Male; D038642:Shaken Baby Syndrome / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology; D017585:Ultrasonography, Doppler, Transcranial