Pd(II)-catalyzed ortho-trifluoromethylation of arenes using TFA as a promoter.
A Pd(II)-catalyzed C-H activation/trifluoromethylation of arenes with an electrophilic trifluoromethylation reagent using diverse heterocycle directing groups is reported. The presence of trifluoroacetic acid is crucial for this catalytic reaction.
Wang
Xisheng
X
Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Truesdale
Larry
L
Yu
Jin-Quan
JQ
D001554:Benzene / Q000737:chemistry*; D002384:Catalysis; D005025:Ethylene Dichlorides / Q000737:chemistry; D008745:Methylation; D010165:Palladium / Q000737:chemistry*; D014269:Trifluoroacetic Acid / Q000737:chemistry*
D005025:Ethylene Dichlorides; D010165:Palladium; D014269:Trifluoroacetic Acid; D001554:Benzene