An intra-host mathematical model on interaction between HIV and malaria.
In this paper a mathematical model is proposed for the interaction of the immune system with HIV viruses and malaria parasites in an individual host. It consists of a system of three coupled ordinary differential equations, which represents the rate of change in the concentration of malaria parasites, HIV viruses and immunity effector within a host, respectively. The theoretical model gives insight into the biological balance between pathogen replication and the immune response to the pathogen: persistence versus elimination of the pathogen, which determines the outcome of infection. Dynamical analysis shows that the outcomes of the interactions between the immune system of the host with either malaria parasites or HIV viruses are dramatic such as malaria infection promoting proliferation of HIV virus, HIV infection increasing the risk from malaria and the immune system of the host failing to keep the diseases under control, etc. The results provide a new perspective for understanding of the complexity mechanisms of the co-infection (or dual infection) with malaria and HIV in a host.
Xiao
Dongmei
D
Department of Mathematics, Shanghai Jiao Tong University, Shanghai 200240, China. xiaodm@sjtu.edu.cn
Bossert
William H
WH
D000818:Animals; D003198:Computer Simulation; D006678:HIV / Q000502:physiology*; D015658:HIV Infections / Q000276:immunology / Q000469:parasitology*; D054884:Host-Pathogen Interactions; D006801:Humans; D008288:Malaria / Q000276:immunology / Q000821:virology*; D018448:Models, Immunological; D010961:Plasmodium / Q000502:physiology*