title: The influence of temporal resolution in determining pharmacokinetic parameters from DCE-MRI data.
abstract: We investigated the influence of the temporal resolution of dynamic contrast-enhanced MRI data on pharmacokinetic parameter estimation. Dynamic Gd-DTPA (Gadolinium-diethylene triamine pentaacetic acid) enhanced MRI data of implanted prostate tumors on rat hind limb were acquired at 4.7 T, with a temporal resolution of approximately 5 sec. The data were subsequently downsampled to temporal resolutions in the range of 15 sec to 85 sec, using a strategy that involves a recombination of k-space data. A basic two-compartment model was fit to the contrast agent uptake curves. The results demonstrated that as temporal resolution decreases, the volume transfer constant (K(trans)) is progressively underestimated (approximately 4% to approximately 25%), and the fractional extravascular extracellular space (v(e)) is progressively overestimated (approximately 1% to approximately 10%). The proposed downsampling strategy simulates the influence of temporal resolution more realistically than simply downsampling by removing samples.
authors.affiliation: Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands. m.heisen@tue.nl
authors.forename: Marieke
authors.initials: M
authors.lastname: Heisen
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Fan
authors.forename: Johannes
authors.initials: J
authors.lastname: Buurman
authors.forename: Natal A W
authors.initials: NA
authors.lastname: van Riel
authors.forename: Gregory S
authors.initials: GS
authors.lastname: Karczmar
authors.forename: Bart M
authors.initials: BM
authors.lastname: ter Haar Romeny
mesh_terms: D000818:Animals; D003198:Computer Simulation; D003287:Contrast Media / Q000493:pharmacokinetics; D019786:Gadolinium DTPA / Q000493:pharmacokinetics*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D016247:Information Storage and Retrieval / Q000379:methods*; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D051381:Rats; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013997:Time Factors
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA