Synthesis, chiral resolution, and determination of novel furan lignan derivatives with potent anti-tumor activity.
A kind of racemic furan lignans were synthesized via a novel route, and two optical isomers were obtained through a selective hydrolization. The absolute configurations were determined by circular dichroism spectroscopy after separated through a preparative column. The different activities of isomers and the racemates were evaluated on QGY-7701 and HeLa cell lines, and compound 2c showed the best activity on QGY-7701 and HeLa cell lines with IC(50) 12 microM and 13 microM, respectively.
Sun
Hai Ling
HL
Department of Medicinal Chemistry, College of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
Wang
Tian Tian
TT
Lv
Zhi Liang
ZL
Feng
Ji Lu
JL
Geng
Dong Ping
DP
Li
Yong Mei
YM
Li
Ke
K
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D013237:Stereoisomerism
D000970:Antineoplastic Agents; D005663:Furans; D017705:Lignans