title: Randomized controlled trial of an interactive internet smoking cessation program with long-term follow-up.
abstract: BACKGROUND
  Internet programs for smoking cessation are widely available but few controlled studies demonstrate long-term efficacy.
  
  
  OBJECTIVE
  To determine the 13-month effectiveness of an Internet program presenting a set sequence of interactive steps, and the role of depressed affect.
  
  
  METHODS
  In a randomized controlled trial sponsored by the American Cancer Society, a treatment condition (n = 1,106) was compared to a control site (n = 1,047).
  
  
  RESULTS
  More treatment condition participants were abstinent (30-day point prevalence) than control site participants (12.9% vs. 10.1%, p < .05) at 13 months. This effect was greater among participants not reporting depressed affect (15.0% vs. 10.1%, p < .01). Among smokers who reported depressed affect, there was no difference in abstinence between the treatment and control conditions.
  
  
  CONCLUSIONS
  Data support the long-term efficacy of an Internet intervention for cessation modeled on a structured, in-person treatment approach, especially for participants not experiencing daily depressed affect.
authors.affiliation: Columbia University, New York, NY, USA. dfs2@columbia.edu
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Seidman
authors.forename: J Lee
authors.initials: JL
authors.lastname: Westmaas
authors.forename: Steve
authors.initials: S
authors.lastname: Goldband
authors.forename: Vance
authors.initials: V
authors.lastname: Rabius
authors.forename: Edward S
authors.initials: ES
authors.lastname: Katkin
authors.forename: K Joanne
authors.initials: KJ
authors.lastname: Pike
authors.forename: Dawn
authors.initials: D
authors.lastname: Wiatrek
authors.forename: Richard P
authors.initials: RP
authors.lastname: Sloan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000570:American Cancer Society; D003194:Computer-Assisted Instruction / Q000379:methods; D003863:Depression / Q000209:etiology / Q000517:prevention & control; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D020407:Internet; D008297:Male; D008875:Middle Aged; D015397:Program Evaluation; D012907:Smoking / Q000009:adverse effects / Q000453:epidemiology / Q000523:psychology / Q000628:therapy*; D016540:Smoking Cessation / Q000379:methods* / Q000523:psychology / Q000706:statistics & numerical data; D000074606:Smoking Prevention; D013813:Therapy, Computer-Assisted / Q000379:methods; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States; D055815:Young Adult