title: Dissecting cancer through mathematics: from the cell to the animal model.
abstract: This Timeline article charts progress in mathematical modelling of cancer over the past 50 years, highlighting the different theoretical approaches that have been used to dissect the disease and the insights that have arisen. Although most of this research was conducted with little involvement from experimentalists or clinicians, there are signs that the tide is turning and that increasing numbers of those involved in cancer research and mathematical modellers are recognizing that by working together they might more rapidly advance our understanding of cancer and improve its treatment.
authors.affiliation: School of Mathematical Sciences, University of Nottingham, Nottingham NG7 2RD, UK. Helen.byrne@nottingham.ac.uk
authors.forename: Helen M
authors.initials: HM
authors.lastname: Byrne
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000266:history; D004195:Disease Models, Animal; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology* / Q000503:physiopathology