title: Nucleic acid detection using MNAzymes.
abstract: Deoxyribozymes are promising biotechnological tools. In a recent JACS article, Mokany et al. reported on the design of multi-component deoxyribozyme (MNAzyme) sensors based on 10-23 and 8-17 DNA enzymes. The sensors can detect down to 5 pM of a specific nucleic acid. The versatility of MNAzyme platform allows the design of catalytic cascades for signal amplification. This work is a step forward to PCR-free molecular diagnostics.
authors.affiliation: University of Central Florida, Orlando, FL, USA.
authors.forename: Yulia V
authors.initials: YV
authors.lastname: Gerasimova
authors.forename: Dmitry M
authors.initials: DM
authors.lastname: Kolpashchikov