title: [Solubility enhancement with extrusion technology].
abstract: The transformation of the stable crystalline form can enhance the bioavailability of poorly water soluble drugs. The molecular dispersion, or solid solution, can be formed by various methods. The thermodynamic and kinetic properties of such compounds are very similar to the amorphous state. Twin-screw melt-extrusion, with controlled pressure, heat and shear stress, is a powerful way for separating the molecules of the active ingredient from each other and distributing them in the matrix homogenously. The extrudate can be processed onward immediately after a required cooling phase. The dependence of the possible effect of extrusion on the process parameters was investigated by Raman-microscopy and X-ray powder diffraction in course of the preparation of solid solution of spironolactone.
authors.affiliation: Budapesti Muszaki es Gazdaságtudományi Egyetem, Szerves Kémia es Technológia Tanszék, Budapest, Budafoki ut 8. - 1111. gpatyi@oct.bme.hu
authors.forename: Gergo
authors.initials: G
authors.lastname: Patyi
authors.forename: György
authors.initials: G
authors.lastname: Marosi
authors.forename: István
authors.initials: I
authors.lastname: Antal
authors.forename: Attila
authors.initials: A
authors.lastname: Bódis
mesh_terms: D004364:Pharmaceutical Preparations / Q000737:chemistry*; D012995:Solubility; D013059:Spectrum Analysis, Raman; D013148:Spironolactone / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D004364:Pharmaceutical Preparations; D013148:Spironolactone