Visualizing PKA dynamics in a learning center.
Gervasi et al. report in this issue of Neuron that the mushroom bodies in Drosophila, a critical center for olfactory memory formation, have spatially restricted PKA activity in response to specific neuromodulators. The dunce cAMP-phosphodiesterase and rutabaga adenylyl cyclase genes are necessary for two key properties of PKA dynamics in these neurons.
Zars
Troy
T
Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA. zarst@missouri.edu <zarst@missouri.edu>
D000818:Animals; D001245:Association Learning / Q000502:physiology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D029721:Drosophila Proteins / Q000378:metabolism; D004331:Drosophila melanogaster; D024521:Mushroom Bodies / Q000378:metabolism*; D009833:Olfactory Pathways / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D029721:Drosophila Proteins; D017868:Cyclic AMP-Dependent Protein Kinases