The applied biochemistry of PEDF and implications for tissue homeostasis.
Pigment epithelium-derived factor (PEDF) is an endogenously produced glycoprotein with a spectrum of biological roles across diverse pathologies. Recent research has focused on the biochemical properties of PEDF and its associated receptors. This review discusses the recent developments in PEDF biochemistry and how this new knowledge will help progress our understanding of PEDF as a molecular mediator for anti-angiogenesis and -tumorigenesis. Additionally, pathophysiological roles for PEDF in healing and tissue homeostasis are being revealed and our enhanced understanding of the interactions between PEDF and its receptors may yet prove useful in propelling PEDF towards clinical application.
Broadhead
Matthew L
ML
Department of Orthopaedics, St Vincent's Hospital, University of Melbourne, Melbourne, Vic., Australia.
Becerra
S Patricia
SP
Choong
Peter F M
PF
Dass
Crispin R
CR
D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000502:physiology; D004317:Doxorubicin / Q000627:therapeutic use; D005136:Eye Proteins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D006706:Homeostasis; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D009389:Neovascularization, Pathologic; D009414:Nerve Growth Factors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D018013:Receptors, Neuropeptide / Q000378:metabolism; D055213:Retinal Pigment Epithelium / Q000378:metabolism*; D015842:Serine Proteinase Inhibitors / Q000378:metabolism / Q000494:pharmacology; D015843:Serpins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D014945:Wound Healing / Q000502:physiology; D000099174:Pigment Epithelium-Derived Factor
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D004317:Doxorubicin; D005136:Eye Proteins; D009414:Nerve Growth Factors; D018013:Receptors, Neuropeptide; D015842:Serine Proteinase Inhibitors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor; C400531:pigment epithelium-derived factor receptor