title: The Gewald multicomponent reaction.
abstract: The Gewald reaction of sulfur, cyanoacetic acid derivatives, and oxo-component (G-3CR) yielding highly substituted 2-aminothiophene derivatives has seen diverse applications in combinatorial and medicinal chemistry. Its products are of great use in pharmaceutical industry mainly as small molecular weight inhibitors. We herein review synthetic scope and variations, usage, and structural biology of Gewald products.
authors.affiliation: Department of Pharmaceutical Sciences and Chemistry, University of Pittsburgh, Pittsburgh, PA 15261, USA.
authors.forename: Yijun
authors.initials: Y
authors.lastname: Huang
authors.forename: Alexander
authors.initials: A
authors.lastname: Dömling
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000595:Amino Acid Sequence; D000818:Animals; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D013455:Sulfur / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000085:Acetates; D004791:Enzyme Inhibitors; D013876:Thiophenes; D013455:Sulfur; C007170:cyanoacetic acid