title: Effect of MgO contents on the mechanical properties and biological performances of bioceramics in the MgO-CaO-SiO2 system.
abstract: The aim of this research was to investigate the effect of the chemical composition on the mechanical properties, bioactivity, and cytocompatibility in vitro of bioceramics in the MgO-CaO-SiO(2) system. Three single-phase ceramics (merwinite, akermanite and monticellite ceramics) with different MgO contents were fabricated. The mechanical properties were tested by an electronic universal machine, while the bioactivity in vitro of the ceramics was detected by investigating the bone-like apatite-formation ability in simulated body fluid (SBF), and the cytocompatibility was evaluated through osteoblast proliferation and adhesion assay. The results showed that their mechanical properties were improved from merwinite to akermanite and monticellite ceramics with the increase of MgO contents, whereas the apatite-formation ability in SBF and cell proliferation decreased. Furthermore, osteoblasts could adhere, spread and proliferate on these ceramic wafers. Finally, the elongated appearance and minor filopodia of cells on merwinite ceramic were more obvious than the other two ceramics.
authors.affiliation: College of Materials Science and Engineering, Sichuan University, Chengdu, 610064, Sichuan, People's Republic of China.
authors.forename: Xianchun
authors.initials: X
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Ou
authors.forename: Yan
authors.initials: Y
authors.lastname: Wei
authors.forename: Zhongbing
authors.initials: Z
authors.lastname: Huang
authors.forename: Yunqing
authors.initials: Y
authors.lastname: Kang
authors.forename: Guangfu
authors.initials: G
authors.lastname: Yin
mesh_terms: D000818:Animals; D001031:Apatites / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology; D001826:Body Fluids / Q000737:chemistry; D049109:Cell Proliferation / Q000187:drug effects; D002516:Ceramics / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects; D010012:Osteogenesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012824:Silicic Acid; D012822:Silicon Dioxide / Q000032:analysis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D001031:Apatites; C529763:monticellite; D012824:Silicic Acid; D012822:Silicon Dioxide; C023506:Glass ceramics