Phenolic constituents of the aerial parts of Cimicifuga simplex and Cimicifuga japonica.
Chemical investigation of the aerial parts of Cimicifuga simplex afforded four new fukinolic acid analogues, cimicifugic acids K-N (1-4), and 10 known compounds, and C. japonica afforded three new fukinolic acid analogues, cimicifugic acids K-M (1-3), a new phenolic glycoside, shomaside F (5), and 10 known compounds. Cimicifugic acids K-N showed more potent hyaluronidase inhibitory activities than rosmarinic acid.
Iwanaga
Atsufumi
A
School of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Suruga-ku, Shizuoka 422-8526, Japan.
Kusano
Genjiro
G
Warashina
Tsutomu
T
Miyase
Toshio
T
D002109:Caffeic Acids / Q000737:chemistry / Q000302:isolation & purification*; D031885:Cimicifuga / Q000737:chemistry*; D002934:Cinnamates / Q000494:pharmacology; D053630:Depsides / Q000494:pharmacology; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors*; D007564:Japan; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification*; D010648:Phenylacetates / Q000737:chemistry / Q000302:isolation & purification*; D010946:Plants, Medicinal / Q000737:chemistry*; D000097123:Rosmarinic Acid
D002109:Caffeic Acids; D002934:Cinnamates; D053630:Depsides; D006821:Hyaluronoglucosaminidase; D010636:Phenols; D010648:Phenylacetates; D000097123:Rosmarinic Acid; C116092:cimicifugic acid; C116090:fukinolic acid