title: Anti-diabetes constituents in leaves of Smallanthus sonchifolius.
abstract: The inhibitory effect of smallanthaditerpenic acids A, B, C and D previously isolated from leaves of Smallanthus sonchifolius (yacon) on alpha-glucosidase were examined and their IC50 were determined to be 0.48 mg/mL, 0.59 mg/mL, 1.00 mg/mL, and 1.17 mg/mL respectively. In addition, a rapid, reliable RP-HPLC method for the analysis of chlorogenic acid, caffeic acid, and smallanthaditerpenic acids A and C in yacon leaves was established, and the variation in their contents in leaves from plants cultivated in different places and collected at different times of the year were compared. The established analytical method for determining smallanthaditerpenic acids A and C, chlorogenic acid and caffeic acid presented good results and could be used as a method for the quality control of S. sonchifolius leaves.
authors.affiliation: College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Xiang
authors.forename: Fan
authors.initials: F
authors.lastname: He
authors.forename: Ting-Guo
authors.initials: TG
authors.lastname: Kang
authors.forename: De-Qiang
authors.initials: DQ
authors.lastname: Dou
authors.forename: Kuo
authors.initials: K
authors.lastname: Gai
authors.forename: Yu-Yuan
authors.initials: YY
authors.lastname: Shi
authors.forename: Young-Ho
authors.initials: YH
authors.lastname: Kim
authors.forename: Feng
authors.initials: F
authors.lastname: Dong
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents / Q000032:analysis; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D010936:Plant Extracts