Thalamic activation and cortical deactivation during typical absence status monitored using [18F]FDG-PET: a case report.
We describe the ictal [(18)F]FDG-PET study of a case of absence status showing bilateral thalamic hypermetabolism and frontal cortex hypometabolism. This is the first ictal assessment of absence status by [(18)F]FDG-PET reporting this particular cortical and subcortical involvement. Our findings support the theory of corticothalamic circuitry involvement in the pathophysiology of absence seizures and stress the similarities of the clinical and metabolic pattern observed during absences with the pattern of task-induced interruption of the default state of brain function.
Bilo
Leonilda
L
Epilepsy Center, Department of Neurological Sciences, Federico II University, Naples, Italy. ledabilo@fastwebnet.it
Meo
Roberta
R
de Leva
Maria Fulvia
MF
Vicidomini
Caterina
C
Salvatore
Marco
M
Pappatà
Sabina
S
D002540:Cerebral Cortex; D004832:Epilepsy, Absence / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D013788:Thalamus
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18