Synthesis of 2'-N-formamido nucleosides and biological evaluation.
The 2'-N-formamide derivatives of adenosine, cytidine, and 9-beta-d-arabinofuranosyladenine were synthesized and tested (as triphosphate) for their substrate capacities for the HCV NS5B polymerase.
Abramov
Mikhail
M
Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Leuven, Belgium.
Renders
Marleen
M
Herdewijn
Piet
P
D000577:Amides / Q000737:chemistry*; D001483:Base Sequence; D005561:Formates / Q000737:chemistry*; D016174:Hepacivirus / Q000187:drug effects*; D006526:Hepatitis C / Q000188:drug therapy*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000577:Amides; D005561:Formates; D009705:Nucleosides; C030544:formic acid