title: Dual contrast magnetic resonance imaging tracking of iron-labeled cells in vivo.
abstract: Negative-contrast magnetic resonance imaging (MRI) methods utilizing magnetic susceptibility contrast agents have become one of the most widely used approaches in cellular imaging research. However, visualizing and tracking super-paramagnetic iron oxide nanoparticle (SPIO)-labeled cells on the basis of negative-contrast can limit specificity and sensitivity. Therefore, there has been a strong motivation to explore MRI methods for cellular imaging with either positive or dual contrast (both positive and negative) for identifying labeled cells; these methods offer the potential to improve significantly the sensitivity and specificity of MRI-based cell-tracking approaches. In this review, current state-of-the-art positive- and dual-contrast MRI techniques and contrast agents are described specifically for applications involving in vivo cellular tracking and imaging.
authors.affiliation: Medical Imaging Institute of Tianjin, Tianjin, China.
authors.forename: Shengyong
authors.initials: S
authors.lastname: Wu
authors.forename: Longjiang
authors.initials: L
authors.lastname: Zhang
authors.forename: Jianhui
authors.initials: J
authors.lastname: Zhong
authors.forename: Zhuoli
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000818:Animals; D058948:Cell Tracking; D003287:Contrast Media / Q000737:chemistry; D005290:Ferric Compounds / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000639:trends; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D051379:Mice; D009369:Neoplasms / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; C000499:ferric oxide