Fertility preservation by ovarian stimulation and oocyte cryopreservation in a 14-year-old adolescent with Turner syndrome mosaicism and impending premature ovarian failure.
OBJECTIVE
To report a novel approach to fertility preservation in adolescents with Turner syndrome mosaicism by repeated controlled ovarian stimulation and oocyte cryopreservation.


METHODS
Case report.


METHODS
Academic reproductive medicine center.


METHODS
Fourteen-year-old adolescent diagnosed with Turner syndrome mosaicism.


METHODS
Two cyles of controlled ovarian stimulation and oocyte cryopreservation within 1 year.


METHODS
Recovery of oocytes after controlled ovarian stimulation and oocyte cryopreservation.


RESULTS
Eleven oocytes were retrieved, of which eight were mature and three were immature during the first cycle. One year later, four mature and three immature oocytes were retrieved after a treatment cycle with even higher gonadotropin doses. All oocytes were cryopreserved by vitrification.


CONCLUSIONS
Controlled ovarian stimulation and oocyte cryopreservation may be an option for fertility preservation in selected adolescents with Turner syndrome mosaicism and impending ovarian failure.
Oktay
Kutluk
K
Institute for Fertility Preservation, Department of Obstetrics and Gynecology, NY Medical College-Westchester Medical Center, Valhalla, New York 10595, USA. koktay@fertilitypreservation.org
Rodriguez-Wallberg
Kenny A
KA
Sahin
Gulnaz
G
D000293:Adolescent; D015925:Cryopreservation; D005260:Female; D005298:Fertility; D006801:Humans; D009030:Mosaicism; D009865:Oocytes / Q000166:cytology; D010062:Ovulation Induction; D016649:Primary Ovarian Insufficiency / Q000209:etiology* / Q000628:therapy*; D014424:Turner Syndrome / Q000150:complications* / Q000235:genetics