A totally implanted intra-arterial chemotherapy system for advanced maxillary sinus carcinoma.
CONCLUSIONS
Both reservoir systems for intra-arterial cisplatin and intravenous sodium thiosulfate infusions are low- invasive, safe and effective procedures for treatment of advanced maxillary sinus carcinoma.


OBJECTIVE
To use our reservoir system for intra-arterial high-dose cisplatin infusion therapy in patients with advanced maxillary sinus carcinoma.


METHODS
Eight patients with advanced maxillary sinus carcinomas underwent treatment utilizing intra-arterial cisplatin (CDDP) infusion and radiation therapy followed by planned surgical resection. For intra-arterial infusion of high-dose cisplatin, both intra-arterial and intravenous reservoir systems were used.


RESULTS
CDDP was infused 4-6 times (mean 5.1) and the total dose of CDDP was between 690 and 910 mg (mean 771 mg). The response rate was 100 with 50% CR and 50% PR and all patients underwent medial maxillectomy. Only 1 T(4) patient had local recurrence and 1 other patient had bilateral neck metastasis.
Nakatani
Hiroaki
H
Department of Otolaryngology, Kochi Medical School, Nankoku, Kochi, Japan. hnakatan@tcc.pref.tochigi.lg.jp
Hirose
Kahori
K
Matsumoto
Noboru
N
Yamakawa
Kazuhiro
K
Kakigi
Akinobu
A
Takeda
Taizo
T
Ito
Satoshi
S
Yamanishi
Tomoaki
T
Nishioka
Akihito
A
Ogawa
Yasuhiro
Y
Nakahira
Mitsuhiko
M
D000368:Aged; D002277:Carcinoma / Q000188:drug therapy* / Q000601:surgery; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000188:drug therapy* / Q000601:surgery; D008875:Middle Aged; D016896:Treatment Outcome
D002945:Cisplatin