The relationship between CAG repeat length polymorphism and infertility in Southern Chinese Han women.
OBJECTIVE
To research the relationship between polymorphism of trinucleotide (CAG)n repeat alleles of the Exon 1 of androgen receptor gene and women with polycystic ovary syndrome (PCOS), or with endometriosis.


METHODS
One hundred and forty-one control women and 74 women with PCOS and with endometriosis were recruited. The (CAG)n repeat alleles were genotyped with 3100 genetic analyser. The repeat number and frequency distributions of (CAG)n alleles were compared and analyzed statistically.


RESULTS
The results showed that mean repeat number of the (CAG)n was significantly lower in women with PCOS than in controls (p<0.001). The mean repeat number of the (CAG)n was significantly different between infertile women with endometriosis (p<0.05). However, the differences between infertile women with PCOS and fertile women with PCOS was not significant (p>0.05).


CONCLUSIONS
These data indicated that (CAG)n repeat polymorphism have some influence, but have not a straight relationship in infertile women with PCOS and with endometriosis in this research population.
Tong
D
D
Department of Forensic Medicine, Zhongshan Medical College, Sun Yat-sen University, 510080, Guangzhou, China.
Deng
J
J
Sun
H
H
Chen
L
L
Wu
X
X
D000328:Adult; D044466:Asian People / Q000235:genetics; D004715:Endometriosis / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000235:genetics*; D011085:Polycystic Ovary Syndrome / Q000235:genetics; D011110:Polymorphism, Genetic; D011944:Receptors, Androgen / Q000235:genetics*; D018911:Trinucleotide Repeats / Q000235:genetics*
D011944:Receptors, Androgen