Design, synthesis and biological evaluation of new ionone derivatives as potential neuroprotective agents in cerebral ischemia.
A new series of ionone derived allylic alcohols have been evaluated for anti-ischemic activity. Out of them, 12f and 13b decreased infarct volume to 23.98+/-4.7 mm3 and 93.98+/-24.8 mm3 as compared to ischemic group.
Srivastava
Ajay Kumar
AK
Medicinal & Process Chemistry Division, Central Drug Research Institute, CSIR, Chattar Manzil Palace, Lucknow 226001, UP, India.
Dohare
Preeti
P
Ray
Madhur
M
Panda
Gautam
G
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001929:Brain Edema / Q000188:drug therapy / Q000503:physiopathology; D002545:Brain Ischemia / Q000517:prevention & control*; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D008297:Male; D015394:Molecular Structure; D009474:Neurons / Q000166:cytology / Q000187:drug effects; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045792:Norisoprenoids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D018696:Neuroprotective Agents; D045792:Norisoprenoids