Targeting effectors: the molecular recognition of Type III secreted proteins.
The Type III secretion system (TTSS) facilitates the export of effector proteins from pathogenic and symbiotic Gram-negative bacteria into the cytosol of eukaryotic host cells. The current functional and evolutionary knowledge on the molecular recognition of TTSS substrates and computational models of the secretion signal are discussed in this review.
Arnold
Roland
R
Department of Genome Oriented Bioinformatics, Technische Universität München, Wissenschaftszentrum Weihenstephan, 85350 Freising, Germany.
Jehl
Andre
A
Rattei
Thomas
T
D001426:Bacterial Proteins / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000378:metabolism* / Q000472:pathogenicity; D026901:Membrane Transport Proteins / Q000378:metabolism*; D008954:Models, Biological; D021381:Protein Transport; D037521:Virulence Factors / Q000378:metabolism*
D001426:Bacterial Proteins; D026901:Membrane Transport Proteins; D037521:Virulence Factors