title: Fronto-cingulate effective connectivity in obsessive compulsive disorder: a study with fMRI and dynamic causal modeling.
abstract: Evidence suggests that obsessive compulsive disorder (OCD) is associated with an overactive error control system. A key role in error detection and control has been ascribed to the fronto-cingulate system. However, the exact functional interplay between the single components of this network in OCD is largely unknown. Therefore, the present study combined a univariate data analysis and effective connectivity analysis using dynamic causal modeling (DCM) to examine error control in 21 patients with OCD and 21 matched healthy controls. All subjects performed an adapted version of the Stroop color-word task while undergoing fMRI scans. Enhanced activation in the fronto-cingulate system could be detected in OCD patients during the incongruent task condition. Additionally, task-related modulation of effective connectivity from the dorsal ACC to left DLPFC was significantly stronger in OCD patients. These findings are consistent with an overactive error control system in OCD subserving suppression of prepotent responses during decision-making.
authors.affiliation: Department of Psychiatry, University of Jena, Germany. Ralf.Schloesser@uni-jena.de
authors.forename: Ralf G M
authors.initials: RG
authors.lastname: Schlösser
authors.forename: Gerd
authors.initials: G
authors.lastname: Wagner
authors.forename: Claudia
authors.initials: C
authors.lastname: Schachtzabel
authors.forename: Gregor
authors.initials: G
authors.lastname: Peikert
authors.forename: Kathrin
authors.initials: K
authors.lastname: Koch
authors.forename: Juergen R
authors.initials: JR
authors.lastname: Reichenbach
authors.forename: Heinrich
authors.initials: H
authors.lastname: Sauer
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods; D003072:Cognition Disorders / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006179:Gyrus Cinguli / Q000033:anatomy & histology / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008959:Models, Neurological; D009771:Obsessive-Compulsive Disorder / Q000378:metabolism / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000033:anatomy & histology / Q000378:metabolism / Q000503:physiopathology*