title: Emergence of pristinamycin resistance in India.
abstract: Quinupristin and dalfopristin combination has been advocated as a drug of choice for multi-drug resistant (MDR) gram-positive cocci (GPC). We are reporting two cases of neonatal septicemia, caused by the methicillin resistant Staphylococcus aureus (MRSA), showing primary in vitro pristinamycin resistance. The Minimum inhibitory concentrations (MIC) for pristinamycin in these two cases were 30 mug and 25 mug, respectively. Universal advocacy of pristinamycin for the therapy of MDR GPC infections should be re-evaluated.
authors.affiliation: Department of Pharmacology and Microbiology, Moti Lal Nehru Medical College, Allahabad, Uttar Pradesh, India.
authors.forename: Shyam Sunder
authors.initials: SS
authors.lastname: Keshari
authors.forename: Arun Kumar
authors.initials: AK
authors.lastname: Kapoor
authors.forename: Nira
authors.initials: N
authors.lastname: Kastury
authors.forename: Dharmendra Kumar
authors.initials: DK
authors.lastname: Singh
authors.forename: Anudita
authors.initials: A
authors.lastname: Bhargava