title: Intracerebroventricular injection of L-aspartic acid and L-asparagine induces sedative effects under an acute stressful condition in neonatal chicks.
abstract: The present study was conducted to clarify the central functions of L-aspartic acid (Asp) and L-asparagine (Asn) during an acute stressful condition in chicks. Intracerebroventricular (i.c.v.) injection of Asp and Asn (0.84 micromol) attenuated the vocalization that normally occurs during social separation stress. Asp decreased the time spent in active wakefulness and induced sedation. Asn had a similar effect to Asp, although somewhat weaker. However, i.c.v. injection of Asp and Asn further enhanced plasma corticosterone release under social separation stress. Taken together, the i.c.v. injection of Asp and Asn has sedative effects under an acute stressful condition, which does not involve the hypothalamic-pituitary-adrenal axis.
authors.affiliation: Laboratory of Advanced Animal and Marine Bioresources, Graduate School of Bioresources and Bioenvironmental Sciences, Kyushu University, Higashi, Fukuoka, Japan.
authors.forename: Haruka
authors.initials: H
authors.lastname: Yamane
authors.forename: Mari
authors.initials: M
authors.lastname: Asechi
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Tsuneyoshi
authors.forename: Isao
authors.initials: I
authors.lastname: Kurauchi
authors.forename: D Michael
authors.initials: DM
authors.lastname: Denbow
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Furuse
mesh_terms: D000818:Animals; D001216:Asparagine / Q000008:administration & dosage*; D001224:Aspartic Acid / Q000008:administration & dosage*; D001522:Behavior, Animal / Q000187:drug effects*; D002552:Cerebral Ventricles; D002645:Chickens / Q000502:physiology*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007267:Injections; D013315:Stress, Psychological / Q000188:drug therapy; D014828:Vocalization, Animal / Q000187:drug effects
chemical_list: D006993:Hypnotics and Sedatives; D001224:Aspartic Acid; D001216:Asparagine