Primary metastatic leiomyosarcoma of the fallopian tube: a rare case report.
BACKGROUND
Leiomyosarcoma of the fallopian tube is an extremely unusual gynecologic neoplasm. Since 1886, only 19 of about 35 sarcomas of the fallopian tube have been identified as leiomyosarcomas. As such, clinical diagnosis and therapy management are difficult.


METHODS
We report on the case of a 59-year-old woman with leiomyosarcoma of the fallopian tube and liver metastases at the time of diagnosis. After initial tumor debulking, she received palliative chemotherapy with gemcitabine 900 mg/m(2) (d1+8) and docetaxel 100 mg/m(2) (d8) (q21). For additional bone metastases, she started local radiation plus bisphosphonates (q28). After 2 cycles of chemotherapy, the disease progressed, and the patient died within 8 months of diagnosis. A review of the literature is given.


CONCLUSIONS
Primary metastatic leiomyosarcoma of the fallopian tube is a progressive disease with limited therapy options. For better prognostic evaluation and disease management in such rare cases, it is important to report and compare more cases regarding course of disease and outcome.
Jacobs
Volker R
VR
Department of Obstetrics and Gynecology, Technical University Munich, Germany. volkerjacobs@hotmail.com
Zemzoum
Iris
I
Kremer
Marcus
M
Gottschalk
Nina
N
Baumgärtner
Anne K
AK
Krol
Janna
J
Kiechle
Marion
M
D003131:Combined Modality Therapy; D003952:Diagnostic Imaging; D018450:Disease Progression; D005185:Fallopian Tube Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D005187:Fallopian Tubes / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D010166:Palliative Care; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D011379:Prognosis