title: Toward a practical and waste-free synthesis of thioureas in water.
abstract: An operationally simple and entirely green protocol for the synthesis of thiourea derivatives by the reaction of carbon disulfide with primary amines in pure water is developed. This reaction is a highly atom-economic process for production of highly pure, hindered thioureas without any catalyst and tedious work-up.
authors.affiliation: Research and Technology, Chemistry and Chemical Engineering Research Center of Iran, P.O. Box 14335-186, Tehran, Iran. azizi@ccerci.ac.ir
authors.forename: Najmedin
authors.initials: N
authors.lastname: Azizi
authors.forename: Alireza
authors.initials: A
authors.lastname: Khajeh-Amiri
authors.forename: Hossein
authors.initials: H
authors.lastname: Ghafuri
authors.forename: Mohammad
authors.initials: M
authors.lastname: Bolourtchian
mesh_terms: D055808:Drug Discovery; D055772:Green Chemistry Technology / Q000379:methods*; D013890:Thiourea / Q000138:chemical synthesis*; D014867:Water / Q000737:chemistry*
chemical_list: D014867:Water; D013890:Thiourea