Physiology and pathology of proteostasis in the early secretory compartment.
The endoplasmic reticulum (ER), the port of entry for proteins into the secretory pathway, is a multifunctional organelle emerging as a central integrator of numerous signalling pathways. The mechanisms that control proteostasis are integral part of this signalling network, providing cues for morphological and functional cell remodelling, proliferation, inflammation and cell death. The complexity of ER responses is exploited during physiological and pathological tissue development, cell differentiation and lifespan control. This essay outlines some of the mechanisms that link proteostasis within the early secretory compartment to signalling in development and disease.
Anelli
Tiziana
T
Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Università Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy. anelli.tiziana@hsr.it <anelli.tiziana@hsr.it>
Sitia
Roberto
R
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000378:metabolism* / Q000502:physiology*; D011506:Proteins / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D011506:Proteins