Total synthesis of (+)-chloriolide.
The first total synthesis of (+)-chloriolide, a 12-membered macrolide from Chloridium virescens (var. chlamydosporum), was accomplished in a longest linear sequence of 20 steps from commercial materials in 7% overall yield.
Haug
Timm T
TT
Department Chemie, Technische Universität München, Lichtenbergstr. 4, 85747 Garching, Germany.
Kirsch
Stefan F
SF
D001203:Ascomycota / Q000737:chemistry*; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D018942:Macrolides; C510706:chloriolide