Assessing a dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease) with 7T MR imaging.
Lhermitte-Duclos disease (LDD; dysplastic cerebellar gangliocytoma) is a rare hamartomatous lesion of the cerebellar cortex and this was first described in 1920. LDD is considered to be part of the autosomal-dominant phacomatosis and cancer syndrome Cowden disease (CS). We examined the brain of a 46-year-old man, who displayed the manifestations of CS, with 7 Tesla (T) and 1.5 T MRI and 1.5 T MR spectroscopy (1H-MRS). We discuss the possible benefits of employing ultrahigh-field MRI for making the diagnosis of this rare lesion.
Moenninghoff
Christoph
C
Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany. ch.moenninghoff@uk-essen.de
Kraff
Oliver
O
Schlamann
Marc
M
Ladd
Mark E
ME
Katsarava
Zaza
Z
Gizewski
Elke R
ER
D002525:Cerebellar Cortex / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000150:complications / Q000473:pathology*; D003937:Diagnosis, Differential; D020234:Gait Ataxia / Q000209:etiology; D006223:Hamartoma Syndrome, Multiple / Q000150:complications / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D014717:Vertigo / Q000209:etiology