Rapid synthesis of the indole-indolone scaffold via [3+2] annulation of arynes by methyl indole-2-carboxylates.
The reaction of methyl indole-2-carboxylates and arynes affords a very efficient, high yielding synthesis of a novel indole-indolone ring system, which tolerates considerable functionality, is broad in scope and proceeds under mild reaction conditions.
Rogness
Donald C
DC
Department of Chemistry, Iowa State University, Ames, IA, 50011, U.S.A.
Larock
Richard C
RC