title: Two new cytotoxic cardenolides from the latex of Antiaris toxicaria.
abstract: Two new cardenolides, toxicarioside F (1) and toxicarioside G (2), were isolated from the latex of Antiaris toxicaria (Pers.) Lesch (Moraceae). Their structures were elucidated on the basis of spectral data and chemical evidence. Compounds 1 and 2 showed significant cytotoxicity against K562, SGC-7901, SMMC-7721, and HeLa cell lines in vitro by the MTT method.
authors.affiliation: Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China.
authors.forename: Hao-Fu
authors.initials: HF
authors.lastname: Dai
authors.forename: Yu-Juan
authors.initials: YJ
authors.lastname: Gan
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Que
authors.forename: Jiao
authors.initials: J
authors.lastname: Wu
authors.forename: Zhen-Chang
authors.initials: ZC
authors.lastname: Wen
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Mei
mesh_terms: D031621:Antiaris / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002301:Cardiac Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D020014:K562 Cells; D007840:Latex / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D002301:Cardiac Glycosides; D004365:Drugs, Chinese Herbal; D007840:Latex; C548599:toxicarioside F; C548600:toxicarioside G