title: Chicken collagen hydrolysate protects rats from hypertension and cardiovascular damage.
abstract: We previously reported that chicken collagen hydrolysate (CCH) has strong angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects on spontaneously hypertensive rats. Here, we investigated the chronic therapy effects of CCH on blood pressure and vascular relaxation in a cardiovascular damage model of Wistar-Kyoto rats induced by N-nitro-l-arginine methyl ester (L-NAME). Following co-treatment with CCH for 4 weeks, the increment of systolic blood pressure was suppressed significantly. At 8 weeks, the vasorelaxation of thoracic aorta increased significantly, and cardiovascular damage was ameliorated. The concentration of soluble intercellular adhesion molecule-1 (ICAM-1) in blood was reduced significantly by long-term administration of CCH, whereas the nitric oxide concentration was increased significantly at 1 hour post-treatment. The results suggest that beneficial effects of CCH result from antihypertensive function, but also from inhibition of cardiovascular damage to the endothelial cells via its ACE inhibitory activity and regulation of nitric oxide and ICAM-1, which suggests that CCH may be useful as a medicinal food for patients with cardiovascular disease.
authors.affiliation: R&D Center, Nippon Meat Packers Inc., Tsukuba, Ibaraki, Japan. y.zhang@nipponham.co.jp
authors.forename: Youzuo
authors.initials: Y
authors.lastname: Zhang
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kouguchi
authors.forename: Muneshige
authors.initials: M
authors.lastname: Shimizu
authors.forename: Takashi
authors.initials: T
authors.lastname: Ohmori
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takahata
authors.forename: Fumiki
authors.initials: F
authors.lastname: Morimatsu
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001011:Aorta / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D002645:Chickens; D003094:Collagen / Q000494:pharmacology / Q000627:therapeutic use*; D042783:Endothelial Cells / Q000187:drug effects; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000503:physiopathology; D006868:Hydrolysis; D006973:Hypertension / Q000503:physiopathology / Q000517:prevention & control*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D051381:Rats; D011921:Rats, Inbred WKY; D014652:Vascular Diseases / Q000517:prevention & control; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D018799:Intercellular Adhesion Molecule-1; D009569:Nitric Oxide; D003094:Collagen