Hairy-related transcription factor 2 is not potentially related to congenital heart disease in Chinese patients.
Congenital heart disease (CHD) is the malformation of the heart during embryonic development, contributing to the inadequate function of the heart. A recently suggested gene hairy-related transcription factor 2 (HEY2), is an important determinant of mammalian heart development and functions thereby. We had preformed a direct sequencing within 768 Chinese CHD patients in the HEY2 gene. However, we did not reveal any diagnostic alterations in the coding regions by direct sequencing in HEY2, nevertheless this work expands our knowledge of the causes of CHD in the other way.
Wang
Binbin
B
Graduate school, Peking Union Medical College, Beijing, China.
Zhou
Shiyi
S
Chen
Qiuhong
Q
Xie
XiaoDong
X
Huang
Guoying
G
Wang
Jing
J
Zhoua
Sirui
S
Ma
Xu
X
D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D002681:China; D006330:Heart Defects, Congenital / Q000235:genetics*; D006331:Heart Diseases / Q000151:congenital* / Q000235:genetics*; D006801:Humans; D012097:Repressor Proteins / Q000235:genetics*
D051792:Basic Helix-Loop-Helix Proteins; D012097:Repressor Proteins; C405693:HEY2 protein, human