title: Protracted disseminated skeletal metastases from angiosarcoma of the spleen.
abstract: Angiosarcomas are high-grade vascular tumors associated with poor prognosis due to their aggressive nature. Occasional skeletal manifestations present commonly as osteolytic destruction. The 55-years-old patient presented in this case report had a disease-free 4 years interval between splenectomy after primary angiosarcoma of the spleen and an unusual skeletal metastatic pattern mimicking benign angiomatosis. Despite lacking radiographic evidence for a highly aggressive osseous process, the histopathological resemblance of the bone biopsy with the primary tumor manifestation and the fulminant course of disease after onset of disseminated osseous spread confirmed the malignant character of the vascular tumor. The case demonstrates the highly variable radiographic pattern and particular pathobiological behavior of vascular malignancies.
authors.affiliation: Department of Radiology, Klinikum Bremen-Mitte, Bremen, Germany. bjoern.jobke@helios-kliniken.de
authors.forename: B
authors.initials: B
authors.lastname: Jobke
authors.forename: M
authors.initials: M
authors.lastname: Werner
authors.forename: G
authors.initials: G
authors.lastname: Jundt
authors.forename: H
authors.initials: H
authors.lastname: Ostertag
authors.forename: J
authors.initials: J
authors.lastname: Freyschmidt
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D005260:Female; D006394:Hemangiosarcoma / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D013160:Splenic Neoplasms / Q000473:pathology*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome