title: Multikinase inhibitors in thyroid cancer.
abstract: Biological agents are rapidly developing for the treatment of metastatic RAI resistant thyroid cancer. The most promising results were shown by agents that target BRAF and VEGFR rather than RET. BRAF V600E mutation seems to be positively associated with tumour response by using BRAF targeting agents. With these agents impressive clinical responses and prolonged disease stabilisation were observed. This activity compares favourably with that of chemotherapy with less prominent toxicity, although typically associated drug side-effects should be promptly recognised and managed. To date no drug has proved to prolong survival, as such none of these agents has been approved.
authors.affiliation: Head and Neck Cancer Medical Oncology Unit, Fondazione IRCCS 'Istituto Nazionale dei Tumori', Via Venezian 1, Milan, Italy. lisa.licitra@istitutotumori.mi.it
authors.forename: Lisa
authors.initials: L
authors.lastname: Licitra
authors.forename: Laura D
authors.initials: LD
authors.lastname: Locati
authors.forename: Angela
authors.initials: A
authors.lastname: Greco
authors.forename: Roberta
authors.initials: R
authors.lastname: Granata
authors.forename: P
authors.initials: P
authors.lastname: Bossi
mesh_terms: D001691:Biological Therapy / Q000379:methods; D045744:Cell Line, Tumor; D018572:Disease-Free Survival; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D017354:Point Mutation / Q000235:genetics*; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors / Q000235:genetics*; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality
chemical_list: D066246:ErbB Receptors; D040262:Receptors, Vascular Endothelial Growth Factor; C482119:BRAF protein, human; D048493:Proto-Oncogene Proteins B-raf