title: The design and development of 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides as inhibitors of human cytomegalovirus polymerase.
abstract: Discovery efforts were focused on identifying a non-nucleoside antiviral for treating infections caused by human cytomegalovirus (HCMV) with equal or better potency and diminished toxicity compared to current therapeutics. This Letter describes the HCMV DNA polymerase inhibition and in vitro antiviral activity of various 2-aryl-2-hydroxy ethylamine substituted 1H,7H-pyrido[1,2,3-de]quinoxaline-6-carboxamides.
authors.affiliation: Global Research and Development, Pfizer Inc., San Diego, CA 92121, USA. sptanis@sbcglobal.net
authors.forename: Steven P
authors.initials: SP
authors.lastname: Tanis
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Strohbach
authors.forename: Timothy T
authors.initials: TT
authors.lastname: Parker
authors.forename: Malcom W
authors.initials: MW
authors.lastname: Moon
authors.forename: Suvit
authors.initials: S
authors.lastname: Thaisrivongs
authors.forename: William R
authors.initials: WR
authors.lastname: Perrault
authors.forename: Todd A
authors.initials: TA
authors.lastname: Hopkins
authors.forename: Mary L
authors.initials: ML
authors.lastname: Knechtel
authors.forename: Nancee L
authors.initials: NL
authors.lastname: Oien
authors.forename: Janet L
authors.initials: JL
authors.lastname: Wieber
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Stephanski
authors.forename: Michael W
authors.initials: MW
authors.lastname: Wathen
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D015195:Drug Design; D011480:Protease Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D011810:Quinoxalines / Q000737:chemistry* / Q000494:pharmacology; D012697:Serine Endopeptidases / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D011480:Protease Inhibitors; D011810:Quinoxalines; D012697:Serine Endopeptidases; C071910:assemblin