title: Discovery of N-methyl-4-(4-methoxyanilino)quinazolines as potent apoptosis inducers. Structure-activity relationship of the quinazoline ring.
abstract: As a continuation of our efforts to discover and develop apoptosis inducing N-methyl-4-(4-methoxyanilino)quinazolines as novel anticancer agents, we explored substitution at the 5-, 6-, 7-positions of the quinazoline and replacement of the quinazoline by other nitrogen-containing heterocycles. A small group at the 5-position was found to be well tolerated. At the 6-position a small group like an amino was preferred. Substitution at the 7-position was tolerated much less than at the 6-position. Replacing the carbon at the 8-position or both the 5- and 8-positions with nitrogen led to about 10-fold reductions in potency. Replacement of the quinazoline ring with a quinoline, a benzo[d][1,2,3]triazine, or an isoquinoline ring showed that the nitrogen at the 1-position is important for activity, while the carbon at the 2-position can be replaced by a nitrogen and the nitrogen at the 3-position can be replaced by a carbon. Through the SAR study, several 5- or 6-substituted analogs, such as 2a and 2c, were found to have potencies approaching that of lead compound N-(4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine (1g, EP128495, MPC-6827, Azixa).
authors.affiliation: EpiCept Corporation, 6650 Nancy Ridge Drive, San Diego, CA 92121, USA.
authors.forename: Nilantha
authors.initials: N
authors.lastname: Sirisoma
authors.forename: Azra
authors.initials: A
authors.lastname: Pervin
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Songchun
authors.initials: S
authors.lastname: Jiang
authors.forename: J
authors.initials: J
authors.lastname: Adam Willardsen
authors.forename: Mark B
authors.initials: MB
authors.lastname: Anderson
authors.forename: Gary
authors.initials: G
authors.lastname: Mather
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Pleiman
authors.forename: Shailaja
authors.initials: S
authors.lastname: Kasibhatla
authors.forename: Ben
authors.initials: B
authors.lastname: Tseng
authors.forename: John
authors.initials: J
authors.lastname: Drewe
authors.forename: Sui Xiong
authors.initials: SX
authors.lastname: Cai
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D001943:Breast Neoplasms / Q000188:drug therapy; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy; D020169:Caspases / Q000378:metabolism; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D011799:Quinazolines / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines; D020169:Caspases