title: CD24 and galectin-1 expressions in gastric adenocarcinoma and clinicopathologic significance.
abstract: CD24 and galectin-1 expression in gastric adenocarcinoma and their clinicopathologic significance remained largely unknown. We aimed to evaluate expressions and staining intensities of CD24 and galectin-1 in gastric adenocarcinoma and to investigate the interrelation with clinicopathologic parameters including survival. 93 cases with gastric adenocarcinoma were reevaluated histopathologically and immunohistochemistry was performed with antibodies against CD24 and galectin-1. Staining intensities of both markers in tumor cells and staining intensity of galectin-1 in tumor-associated stromal cells were scored semiquantitatively. The relationship between expression and staining intensity of CD24 and galectin-1 and clinicopathologic variables were assessed. CD24 staining intensity was associated with lymphovascular invasion (p = 0.007), serosal invasion (p = 0.001), stage (p = 0.001) and lymph node metastasis (p = 0.005). Galectin-1 staining intensity in tumor-associated stromal cells was associated with tumor location (p = 0.031), lymphovascular invasion (p = 0.001), perineural invasion (p = 0.001), serosal invasion (p = 0.001), differentiation (p = 0.003), stage (p = 0.001) and lymph node metastasis (p = 0.001). Staining intensity of CD24 (p = 0.019) and gal-1 (p = 0.018) were associated with patient survival. Staining intensity of CD24 in tumor cells and galectin-1 in tumor-associated stromal cells were related with certain clinicopathologic variables. Our findings suggest that these markers are independent prognostic indicators of poor survival and may serve as useful targets for novel therapies.
authors.affiliation: Department of Pathology, School of Medicine, Zonguldak Karaelmas University, 67600 Kozlu, Zonguldak, Turkey. sibel_bektas@yahoo.com
authors.forename: Sibel
authors.initials: S
authors.lastname: Bektas
authors.forename: Burak
authors.initials: B
authors.lastname: Bahadir
authors.forename: Bulent Hamdi
authors.initials: BH
authors.lastname: Ucan
authors.forename: Sukru Oguz
authors.initials: SO
authors.lastname: Ozdamar
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D051927:CD24 Antigen / Q000096:biosynthesis*; D016009:Chi-Square Distribution; D015331:Cohort Studies; D005260:Female; D037483:Galectin 1 / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: D051927:CD24 Antigen; C497889:CD24 protein, human; D037483:Galectin 1