Inhibitory effects of indirubin derivatives on the growth of HL-60 leukemia cells.
Six indirubin derivatives have been synthesized and their inhibitory effects on the growth of HL-60 human promyelocytic leukemia cells investigated. Cell viability was determined using the trypan blue exclusion method. Indirubin-3'-oxime (I-1) inhibited the growth of HL-60 cells with a GI50 value of 36.6 microM, whereas I-0, I-2, I-3, I-4 and I-6 showed only weak cytotoxic activities against HL-60 cancer cells with GI50 values in the range of 97.3 to over 100 microM. These results indicate that indirubin derivatives might be useful candidate agents for exploring potential antileukemic drugs.
Cuong
Nguyen Manh
NM
Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Rd, Caugiay, Hanoi, Vietnam. nmcuong_inpc@yahoo.com.vn
Tai
Bui Huu
BH
Hoan
Dang Hoang
DH
Huong
Tran Thu
TT
Kim
Young Ho
YH
Hyun
Jae-Hee
JH
Kang
Hee-Kyoung
HK
D000903:Antibiotics, Antineoplastic / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry
D000903:Antibiotics, Antineoplastic; D007211:Indoles; C027185:indirubin