title: COX-2 is associated with periodontitis in Europeans.
abstract: COX-2 plays an important role in periodontitis by mediating inflammatory reactions in periodontal tissues, and the COX-2 polymorphisms rs20417 and rs689466 have been reported to be associated with periodontitis in populations of Taiwanese and Chinese ethnicity. To test whether these variants were associated with periodontitis in populations of European ethnicity, we genotyped the single-nucleotide polymorphisms (SNPs) rs689466 and rs6681231, the latter a haplotype tagging SNP (htSNP) for rs20417 (r2>0.95), in our large-analysis population of individuals with aggressive (n = 532) and chronic periodontitis (n = 1052), and 2873 healthy control individuals. The rare G allele of htSNP rs6681231 was associated with aggressive periodontitis prior to and after adjustment for the covariates smoking, diabetes, and gender, with an odds ratio of 1.57 (95% confidence interval 1.18-2.08; p = 0.002). The validation of the association of rs20417 by the htSNP rs6681231 provides evidence for a general genetic risk of COX-2 variants in the pathogenesis of periodontitis.
authors.affiliation: Christian-Albrechts-University, Institute for Clinical Molecular Biology, Schittenhelmstrasse 12, 24105 Kiel, Germany. a.schaefer@ikmb.uni-kiel.de
authors.forename: A S
authors.initials: AS
authors.lastname: Schaefer
authors.forename: G M
authors.initials: GM
authors.lastname: Richter
authors.forename: M
authors.initials: M
authors.lastname: Nothnagel
authors.forename: M L
authors.initials: ML
authors.lastname: Laine
authors.forename: B
authors.initials: B
authors.lastname: Noack
authors.forename: J
authors.initials: J
authors.lastname: Glas
authors.forename: J
authors.initials: J
authors.lastname: Schrezenmeir
authors.forename: B
authors.initials: B
authors.lastname: Groessner-Schreiber
authors.forename: S
authors.initials: S
authors.lastname: Jepsen
authors.forename: B G
authors.initials: BG
authors.lastname: Loos
authors.forename: S
authors.initials: S
authors.lastname: Schreiber
mesh_terms: D000328:Adult; D010520:Aggressive Periodontitis / Q000201:enzymology* / Q000235:genetics; D000483:Alleles; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000201:enzymology* / Q000235:genetics; D051546:Cyclooxygenase 2 / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D005858:Germany; D006801:Humans; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People / Q000235:genetics
chemical_list: D005819:Genetic Markers; D051546:Cyclooxygenase 2