Polymorphisms in matrix metalloproteinase-1, -9 and -12 genes and the risk of chronic obstructive pulmonary disease in a Korean population.
BACKGROUND
Although a few studies have been conducted to evaluate the association of polymorphisms in matrix metalloproteinase (MMP) genes with chronic obstructive pulmonary disease (COPD), the results have been inconsistent.


OBJECTIVE
To investigate the association of 3 polymorphisms of MMP genes (MMP-1 -1607G-->GG, MMP-9 -1562C-->T and MMP-12 N357S), which have been reported to be associated with COPD-related phenotypes, with the risk of COPD in a Korean population.


METHODS
The genotypes of the 3 polymorphisms were determined in 301 patients with COPD and 333 healthy controls.


RESULTS
Of the 3 polymorphisms studied, only the distribution of the MMP-9 -1562C-->T genotypes was significantly different between the cases and controls (p = 0.01), with the frequency of the variant T allele being significantly lower in the cases than in the controls (10.4 vs. 15.7%; p = 0.006). Individuals with at least 1 variant T allele were at a significantly decreased risk of COPD when compared with those with homozygous wild-type alleles (adjusted odds ratio = 0.69; 95% CI = 0.45-0.98; p = 0.04).


CONCLUSIONS
These findings suggest that the MMP-9 -1562C-->T polymorphism could be used as a marker for determining the genetic susceptibility to COPD in a Korean population.
Lee
Shin-Yup
SY
Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.
Kim
Min-Jung
MJ
Kang
Hyo-Gyung
HG
Yoo
Seung-Soo
SS
Choi
Yi-Young
YY
Lee
Won-Kee
WK
Cha
Seung-Ick
SI
Kim
Chang-Ho
CH
Jung
Tae-Hoon
TH
Park
Jae-Yong
JY
D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D006801:Humans; D007723:Korea; D008297:Male; D020782:Matrix Metalloproteinases / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D029424:Pulmonary Disease, Chronic Obstructive / Q000201:enzymology / Q000235:genetics*; D012907:Smoking / Q000009:adverse effects
D020782:Matrix Metalloproteinases