title: Radiation dose-volume effects of optic nerves and chiasm.
abstract: Publications relating radiation toxicity of the optic nerves and chiasm to quantitative dose and dose-volume measures were reviewed. Few studies have adequate data for dose-volume outcome modeling. The risk of toxicity increased markedly at doses >60 Gy at approximately 1.8 Gy/fraction and at >12 Gy for single-fraction radiosurgery. The evidence is strong that radiation tolerance is increased with a reduction in the dose per fraction. Models of threshold tolerance were examined.
authors.affiliation: Department of Radiation Oncology, University of Massachusetts School of Medicine, Worcester, MA 01655, USA. charles.mayo@umassmemorial.org
authors.forename: Charles
authors.initials: C
authors.lastname: Mayo
authors.forename: Mary K
authors.initials: MK
authors.lastname: Martel
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Marks
authors.forename: John
authors.initials: J
authors.lastname: Flickinger
authors.forename: Jiho
authors.initials: J
authors.lastname: Nam
authors.forename: John
authors.initials: J
authors.lastname: Kirkpatrick
mesh_terms: D000367:Age Factors; D006801:Humans; D020714:Maximum Tolerated Dose; D008954:Models, Biological; D009897:Optic Chiasm / Q000033:anatomy & histology / Q000528:radiation effects; D009900:Optic Nerve / Q000033:anatomy & histology / Q000528:radiation effects*; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000150:complications*; D011836:Radiation Tolerance; D016634:Radiosurgery / Q000009:adverse effects; D011878:Radiotherapy / Q000009:adverse effects; D014786:Vision Disorders / Q000209:etiology*