title: Towards a Brucella vaccine for humans.
abstract: There is currently no licensed vaccine for brucellosis in humans. Available animal vaccines may cause disease and are considered unsuitable for use in humans. However, the causative pathogen, Brucella, is among the most common causes of laboratory-acquired infections and is a Center for Disease Control category B select agent. Thus, human vaccines for brucellosis are required. This review highlights the considerations that are needed in the journey to develop a human vaccine, including animal models, and includes an assessment of the current status of novel vaccine candidates.
authors.affiliation: Department of Biomedical Sciences, Defence Science and Technology Laboratory, Porton Down, Salisbury, Wiltshire, UK.
authors.forename: Stuart D
authors.initials: SD
authors.lastname: Perkins
authors.forename: Sophie J
authors.initials: SJ
authors.lastname: Smither
authors.forename: Helen S
authors.initials: HS
authors.lastname: Atkins
mesh_terms: D000818:Animals; D002002:Brucella / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D002004:Brucella Vaccine / Q000008:administration & dosage / Q000276:immunology*; D002006:Brucellosis / Q000276:immunology / Q000517:prevention & control*; D004195:Disease Models, Animal; D006801:Humans
chemical_list: D002004:Brucella Vaccine