title: Triterpenoids from Calophyllum inophyllum and their growth inhibitory effects on human leukemia HL-60 cells.
abstract: A new friedelane-type triterpene (1), along with seven known triterpenoids, was isolated from the stems and leaves of Calophyllum inophyllum Linn. Their structures were established as 3beta, 23-epoxy-friedelan-28-oic acid (1), friedelin (2), epifriedelanol (3), canophyllal (4), canophyllol (5), canophyllic acid (6), 3-oxo-friedelan-28-oic acid (7), and oleanolic acid (8) by spectroscopic methods (NMR, EI-MS). The growth inhibitory effects of these triterpenoids on human leukemia HL-60 cells were determined.
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Yan-Zhi
authors.initials: YZ
authors.lastname: Li
authors.forename: Zhan-Lin
authors.initials: ZL
authors.lastname: Li
authors.forename: Shi-Liang
authors.initials: SL
authors.lastname: Yin
authors.forename: Guang
authors.initials: G
authors.lastname: Shi
authors.forename: Ming-Sheng
authors.initials: MS
authors.lastname: Liu
authors.forename: Yong-Kui
authors.initials: YK
authors.lastname: Jing
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Hua
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D029759:Calophyllum / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: C553624:3beta,23-epoxy-friedelan-28-oic acid; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes