title: The first woman to give birth to two children following transplantation of frozen/thawed ovarian tissue.
abstract: Worldwide eight children have been born as a result of transplanting frozen/thawed ovarian tissue. Two of these children were born in Denmark following transport of the ovarian tissue for a period of 5 h prior to cryopreservation. One of these women, who was originally transplanted with six pieces of ovarian cortex, after having experienced a period of menopause has now conceived again following natural conception. She gave birth to a healthy girl on 23 September 2008 and is therefore the first woman in the world to have had two children, from separate pregnancies, born as a result of transplanting frozen/thawed ovarian tissue. This result encourages further development of cryopreservation of ovarian tissue for fertility preservation as a clinical procedure for girls and young women facing gonadotoxic treatment.
authors.affiliation: Department of Gynecology and Obstetrics, Aarhus University Hospital, Aarhus, Denmark.
authors.forename: Erik
authors.initials: E
authors.lastname: Ernst
authors.forename: Stinne
authors.initials: S
authors.lastname: Bergholdt
authors.forename: Jan Stener
authors.initials: JS
authors.lastname: Jørgensen
authors.forename: Claus Yding
authors.initials: CY
authors.lastname: Andersen
mesh_terms: D000328:Adult; D015925:Cryopreservation / Q000379:methods; D003718:Denmark; D005260:Female; D005298:Fertility; D006801:Humans; D007231:Infant, Newborn; D010053:Ovary / Q000502:physiology / Q000637:transplantation*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000503:physiopathology; D011256:Pregnancy Outcome; D012512:Sarcoma, Ewing / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D013997:Time Factors; D014182:Transplantation, Autologous