[Inflammation and vascular calcifications].
Vascular calcifications are feature of late stages of atherosclerosis and are associated with cardiovascular disease. Numerous pathologies like diabetes or chronic renal insufficiency were also associated with the development of vascular calcification, particularly in the artery media. In the past, vascular calcifications were considered like a passive and degenerative event. Several studies have allowed demonstrating that they are the results of an active and inflammatory regulated process. A new idea emerges related to the role of calcifications as a cause of inflammation resulting in a vicious circle between inflammation and vascular calcification. This revue proposes to present an update on these different phenomenons.
Six
Isabelle
I
Inserm, Facultés de Médecine et de Pharmacie, Amiens, France.
Massy
Ziad A
ZA
D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology; D002114:Calcinosis / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology*