Plasma B-type natriuretic peptide level and cardiovascular events in chronic kidney disease in a community-based population.
BACKGROUND
Plasma B-type natriuretic peptide (BNP) levels are confounded by renal dysfunction, so this study examined whether plasma BNP might be a reliable biomarker of the onset of cardiovascular (CV) events in a population-based cohort with impaired renal function.


RESULTS
Baseline data, including plasma BNP, serum creatinine, and urinary protein levels, were determined in participants from a community-based population. Estimated glomerular filtration rate (eGFR) was calculated, and chronic kidney disease (CKD) was defined as either: eGFR <60 mlxmin(-1)x1.73 m(-2) and/or proteinuria (CKD definition-1) or GFR <60 mlxmin(-1)x1.73 m(-2) (CKD definition-2). The CV endpoint was surveyed prospectively. The cohorts were followed for 5,275 person-years for CKD definition-1, and for 4,350 person-years for CKD definition-2. The CV event-free survival rate in the highest BNP quartile in either CKD definition was the lowest among the quartile groups (P<0.001). In multivariate Cox regression models adjusted by traditional CV risk factors and atrial fibrillation, relative risk (RR) for CV events was significantly higher in the highest BNP quartile compared with the lowest BNP quartile (CKD definition-1, RR 3.51, P<0.01: CKD definition-2, RR 4.67, both P<0.01).


CONCLUSIONS
Plasma BNP level provides strong predictive information about the future onset of CV events in CKD subjects selected from the general population.
Sakuma
Masafumi
M
Department of Internal Medicine, Cardiology Division, Iwate Medical University, Morioka, Japan.
Nakamura
Motoyuki
M
Tanaka
Fumitaka
F
Onoda
Toshiyuki
T
Itai
Kazuyoshi
K
Tanno
Kozo
K
Ohsawa
Masaki
M
Sakata
Kiyomi
K
Yoshida
Yuki
Y
Kawamura
Kazuko
K
Makita
Shinji
S
Okayama
Akira
A
D000368:Aged; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000453:epidemiology*; D002908:Chronic Disease; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011446:Prospective Studies; D012307:Risk Factors
D015415:Biomarkers; D020097:Natriuretic Peptide, Brain; D003404:Creatinine