Influence of a low dose of amphetamine on vesicular monoamine transporter binding: a PET (+)[11C]DTBZ study in humans.
We previously reported increased binding of (+)[11C]DTBZ (dihydrotetrabenazine), the vesicular monoamine transporter (VMAT2) positron emission tomography (PET) radioligand, in striatum of some methamphetamine users. This finding might be explained by stimulant-induced vesicular DA depletion resulting in decreased DA (+)[11C]DTBZ competition at VMAT2. In a prospective PET study, we now find that administration of an acute oral dose of amphetamine (0.4 mg/kg) to humans does not cause increased striatal (+)[11C]DTBZ binding but a slight 5% decrease. Our data suggest that a low amphetamine dose is unlikely to cause sufficient DA depletion to detect increased (+)[11C]DTBZ binding and that a higher dose might be required.
Boileau
Isabelle
I
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada. isabelle_boileau@camh.net
Houle
Sylvain
S
Rusjan
Pablo M
PM
Furukawa
Yoshiaki
Y
Wilkins
Diana
D
Tong
Junchao
J
Selby
Peter
P
Wilson
Alan A
AA
Kish
Stephen J
SJ
D000284:Administration, Oral; D000328:Adult; D000661:Amphetamine / Q000494:pharmacology*; D019969:Amphetamine-Related Disorders / Q000378:metabolism / Q000503:physiopathology; D001667:Binding, Competitive / Q000187:drug effects / Q000502:physiology; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D049268:Positron-Emission Tomography / Q000379:methods*; D011446:Prospective Studies; D013747:Tetrabenazine / Q000031:analogs & derivatives* / Q000378:metabolism; D050493:Vesicular Monoamine Transport Proteins / Q000187:drug effects* / Q000378:metabolism; D055815:Young Adult
D000697:Central Nervous System Stimulants; C493452:SLC18A2 protein, human; D050493:Vesicular Monoamine Transport Proteins; C032811:dihydrotetrabenazine; D000661:Amphetamine; D004298:Dopamine; D013747:Tetrabenazine