Human nucleoside transporters: biomarkers for response to nucleoside drugs.
This review describes recent advances in developing human nucleoside transporters (hNTs) as biomarkers to predict response to nucleoside analog drugs with clinical activity. Understanding processes that contribute to drug response or lack thereof will provide strategies to potentiate efficacy or avoid toxicities of nucleoside analog drugs. hNT abundance, evaluated by immunohistochemical methods, has shown promise as a predictive marker to assess clinical drug response that could be used to identify patients who would most likely benefit from nucleoside analog drug treatment.
Damaraju
Vijaya L
VL
Department of Oncology, University of Alberta, Edmonton, Alberta, Canada.
Sawyer
Michael B
MB
Mackey
John R
JR
Young
James D
JD
Cass
Carol E
CE
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015415:Biomarkers / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D033703:Nucleoside Transport Proteins / Q000378:metabolism*; D009705:Nucleosides / Q000494:pharmacology / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D015415:Biomarkers; D033703:Nucleoside Transport Proteins; D009705:Nucleosides