title: Iodine intake as a determinant of thyroid disorders in populations.
abstract: Depending on the availability of iodine, the thyroid gland is able to enhance or limit the use of iodine for thyroid hormone production. When compensation fails, as in severely iodine-deficient populations, hypothyroidism and developmental brain damage will be the dominating disorders. This is, out of all comparison, the most serious association between disease and the level of iodine intake in a population. In less severe iodine deficiency, the normal thyroid gland is able to adapt and keep thyroid hormone production within the normal range. However, the prolonged thyroid hyperactivity associated with such adaptation leads to thyroid growth, and during follicular cell proliferation there is a tendency to mutations leading to multifocal autonomous growth and function. In populations with mild and moderate iodine deficiency, such multifocal autonomous thyroid function is a common cause of hyperthyroidism in elderly people, and the prevalence of thyroid enlargement and nodularity is high. The average serum TSH tends to decrease with age in such populations caused by the high frequency of autonomous thyroid hormone production. On the other hand, epidemiological studies have shown that hypothyroidism is more prevalent in populations with a high iodine intake. Probably, this is also a complication to thyroid adaptation to iodine intake. Many thyroid processes are inhibited when iodine intake becomes high, and the frequency of apoptosis of follicular cells becomes higher. Abnormal inhibition of thyroid function by high levels of iodine is especially common in people affected by thyroid autoimmunity (Hashimoto's thyroiditis). In populations with high iodine intake, the average serum thyroid-stimulating hormone (TSH) tends to increase with age. This phenomenon is especially pronounced in Caucasian populations with a genetically determined high tendency to thyroid autoimmunity. A small tendency to higher serum TSH may be observed already when iodine intake is brought from mildly deficient to adequate, but there is at present no evidence that slightly elevated serum TSH in elderly people leads to an increase in morbidity and mortality.
  
  
  CONCLUSIONS
  Even minor differences in iodine intake between populations are associated with differences in the occurrence of thyroid disorders. Both iodine intake levels below and above the recommended interval are associated with an increase in the risk of disease in the population. Optimally, iodine intake of a population should be kept within a relatively narrow interval where iodine deficiency disorders are prevented, but not higher. Monitoring and adjusting of iodine intake in a population is an important part of preventive medicine.
authors.affiliation: Department of Endocrinology, Aalborg Hospital, Aarhus University Hospital, DK - 9000 Aalborg, Denmark. peter.laurberg@rn.dk
authors.forename: Peter
authors.initials: P
authors.lastname: Laurberg
authors.forename: Charlotte
authors.initials: C
authors.lastname: Cerqueira
authors.forename: Lars
authors.initials: L
authors.lastname: Ovesen
authors.forename: Lone Banke
authors.initials: LB
authors.lastname: Rasmussen
authors.forename: Hans
authors.initials: H
authors.lastname: Perrild
authors.forename: Stig
authors.initials: S
authors.lastname: Andersen
authors.forename: Inge Bülow
authors.initials: IB
authors.lastname: Pedersen
authors.forename: Allan
authors.initials: A
authors.lastname: Carlé
mesh_terms: D001927:Brain Diseases / Q000453:epidemiology / Q000209:etiology; D003718:Denmark / Q000453:epidemiology; D004435:Eating / Q000502:physiology*; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D007455:Iodine / Q000008:administration & dosage* / Q000009:adverse effects / Q000172:deficiency; D011153:Population; D011247:Pregnancy; D037841:Pregnant People; D013959:Thyroid Diseases / Q000453:epidemiology / Q000209:etiology*
chemical_list: D007455:Iodine