Hypophosphataemic osteomalacia in neurofibromatosis.
Oncogenic Osteomalacia syndrome is associated with mesenchymal tumours, caused by a protein secreted from tumours which inhibits tubular renal phosphate absorption and reduces 1,25 dihydroxy vitamin-D renal conversion. It manifests as osteomalacia with hypophosphataemia and hyperphosphaturia. Association of neurofibromatosis with oncogenic osteomalacia is unusual. We report a rare case of oncogenic osteomalacia with generalized neurofibromatosis which presented to us as pathological fracture.
Chadha
Manish
M
Department of Orthopaedics, University College of Medical Sciences & Guru Teg Bahadur Hospital, Delhi, India.
Singh
Ajay Pal
AP
Singh
Arun Pal
AP
D005260:Female; D005264:Femoral Fractures / Q000209:etiology; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D017674:Hypophosphatemia / Q000150:complications*; D008875:Middle Aged; D017253:Neurofibromatoses / Q000150:complications*; D010018:Osteomalacia / Q000150:complications*