title: Critical pneumonia complicating early-stage pregnancy.
abstract: We present a case of community-acquired methicillin-resistant Staphylococcus aureus necrotizing pneumonia, Panton-Valentine leukocidin positive, in a woman at 14 weeks of pregnancy. To our knowledge, this is the first case reporting this critical lung infection occurring during an early phase of pregnancy. This case study alerts physicians to the increasing worldwide spread of these uncommon yet virulent and potentially lethal infections. In our patient, antibiotic therapy with linezolid plus rifampin started at 14 weeks of pregnancy had a successful outcome without inducing toxicity or teratogenesis in the fetus.
authors.affiliation: Università Sapienza di Roma, II Facoltà di Medicina e Chirurgia, Ospedale Sant'Andrea, via di Grottarossa 1035, Rome, Italy. mamerx@gmail.com
authors.forename: Marco
authors.initials: M
authors.lastname: Mercieri
authors.forename: Roberta
authors.initials: R
authors.lastname: Di Rosa
authors.forename: Annalisa
authors.initials: A
authors.lastname: Pantosti
authors.forename: Roberto Alberto
authors.initials: RA
authors.lastname: De Blasi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pinto
authors.forename: Roberto
authors.initials: R
authors.lastname: Arcioni
mesh_terms: D000081:Acetamides / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001427:Bacterial Toxins / Q000378:metabolism; D004359:Drug Therapy, Combination; D005098:Exotoxins / Q000378:metabolism; D005260:Female; D006801:Humans; D007956:Leukocidins / Q000378:metabolism; D000069349:Linezolid; D008168:Lung / Q000000981:diagnostic imaging / Q000187:drug effects / Q000382:microbiology*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification* / Q000378:metabolism; D009336:Necrosis; D023303:Oxazolidinones / Q000627:therapeutic use; D011023:Pneumonia, Staphylococcal / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology*; D011261:Pregnancy Trimester, First; D011859:Radiography; D012293:Rifampin / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; D023303:Oxazolidinones; C078284:Panton-Valentine leukocidin; D000069349:Linezolid; D012293:Rifampin