Approaching the molecular and physiological function of macroH2A variants.
The transition of a cell from one state to another involves large changes in the organization of its chromatin. Indeed, it has become increasingly clear that modifications of the chromatin are the molecular basis of an epigenetic memory that defines cellular identity. Histone variants are likely candidates to contribute to epigenetic regulations. Genome-wide profiling of the unusual macroH2A histone variants and the identification of interacting proteins provided important clues to their molecular and physiological function.
Buschbeck
Marcus
M
Institut for Predictive and Personalized Medicine of Cancer (IMPPC), Badalona, Spain. mbuschbeck@imppc.org
Di Croce
Luciano
L
D000818:Animals; D006657:Histones / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D009707:Nucleosomes / Q000378:metabolism; D011485:Protein Binding; D020033:Protein Isoforms / Q000378:metabolism
D006657:Histones; D009707:Nucleosomes; D020033:Protein Isoforms; C120756:macroH2A histone