Association analysis between polymorphism rs2373115 of gene GRB-associated binding protein 2 and Mongolian Alzheimer patients.
GRB-associated binding protein 2 (GAB2) may function as a risk factor of Alzheimer disease (AD) by affecting hyperphosphorylation of tau, causing neurofibrillary tangles. There had been genomewide analysis discovering polymorphism rs2373115 correlated with AD and in this study we performed an association analysis on this polymorphism in 107:100 Mongolian Alzheimer patients and controls in order to discover whether this correlation can be replicated in Chinese minority group. The results showed negative results, indicating GAB2 rs2373115 polymorphism was not a remarkable factor in developing Alzheimer disease among Mongolian.
Zhou
Sirui
S
Graduate School, Peking Union Medical College, Beijing 100730, China.
Huriletemuer
Wang
Jing
J
Wang
Binbin
B
Zhao
Shigang
S
Wang
De Sheng
de S
Zhang
Chunyu
C
Ma
Xu
X
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics*; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D044466:Asian People; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008986:Mongolia; D011110:Polymorphism, Genetic
D048868:Adaptor Proteins, Signal Transducing; C490895:GAB2 protein, human