Synthesis and evaluation of duocarmycin SA analogs incorporating the methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) alkylation subunit.
The design, synthesis and evaluation of methyl 1,2,8,8a-tetrahydrocyclopropa[c]oxazolo[2,3-e]indol-4-one-6-carboxylate (COI) derivatives are detailed representing analogs of duocarmycin SA containing an oxazole replacement for the fused pyrrole found in the alkylation subunit.
Boyle
Kristopher E
KE
Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA.
MacMillan
Karen S
KS
Ellis
David A
DA
Lajiness
James P
JP
Robertson
William M
WM
Boger
Dale L
DL
D000477:Alkylating Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000478:Alkylation; D000080890:Duocarmycins; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010080:Oxazoles / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
D000477:Alkylating Agents; D000080890:Duocarmycins; D007211:Indoles; D010080:Oxazoles; D011758:Pyrroles; C066098:duocarmycin SA