title: Optical micro-angiography images structural and functional cerebral blood perfusion in mice with cranium left intact.
abstract: Alteration in regional cerebral blood flow (CBF) is the direct result of changes in neuronal activity. It is crucial to monitor the spatio-temporal characteristics of cerebro-vascular blood perfusion in the studies of cerebral diseases. Optical micro-angiography (OMAG) is a recently developed imaging technique capable of resolving 3D distribution of dynamic blood perfusion at a capillary level resolution within microcirculatory beds in vivo. The authors report the applications of OMAG in mouse ischemic stroke model. The study demonstrates that OMAG is a useful method capable of providing in vivo serial assessment of 3D cerebro-vascular pathophysiology with high sensitivity, and therefore, has the potential for use in the study of brain disorders and repairs.
authors.affiliation: Department of Biomedical Engineering, Oregon Health & Science University, 3303 SW Bond Avenue, Portland, OR 97239, USA.
authors.forename: Yali
authors.initials: Y
authors.lastname: Jia
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
mesh_terms: D000792:Angiography / Q000379:methods*; D000818:Animals; D002545:Brain Ischemia / Q000150:complications; D002560:Cerebrovascular Circulation; D008297:Male; D051379:Mice; D057054:Molecular Imaging; D055620:Optical Phenomena; D012886:Skull / Q000098:blood supply* / Q000000981:diagnostic imaging*; D020521:Stroke / Q000150:complications / Q000503:physiopathology