title: Copper-catalyzed guanidinylation of aryl iodides: the formation of N,N'-disubstituted guanidines.
abstract: A copper-catalyzed cross-coupling reaction of guanidine nitrate with aryl iodides was used for the formation of N,N'-disubstituted guanidines to be used as potential therapeutics for strokes. A relatively inexpensive commercially available guanidine salt and a series of aryl iodides together with copper iodide and N,N-diethylsalicylamide as an efficient catalyst/ligand system provided a simple diarylation procedure.
authors.affiliation: Department of Chemistry, University of South Florida, 4202 East Fowler Avenue CHE 205A, Tampa, Florida 33620, USA.
authors.forename: Michelle
authors.initials: M
authors.lastname: Cortes-Salva
authors.forename: Be-Lan
authors.initials: BL
authors.lastname: Nguyen
authors.forename: Javier
authors.initials: J
authors.lastname: Cuevas
authors.forename: Keith R
authors.initials: KR
authors.lastname: Pennypacker
authors.forename: Jon C
authors.initials: JC
authors.lastname: Antilla
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006146:Guanidines / Q000138:chemical synthesis* / Q000737:chemistry; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D006146:Guanidines; D006847:Hydrocarbons, Iodinated; D003300:Copper