Molecular characterizations of an inhibitor of apoptosis from Schistosoma japonicum.
Apoptosis is a normal process for regulating cellular death of many organisms. Here, we molecularly characterized an inhibitor of apoptosis from Schistosoma japonicum (SjIAP). The transcription of the SjIAP predominantly occurred at the developmental stages in a final host. Functional assay indicated that the SjIAP could inhibit caspase activity either in 293T cell or in schistosome lysates. Additionally, there were differently expressed profiles of the SjIAP in S. japonicum living in different hosts. Our preliminary results suggest that the SjIAP may play important roles in parasitic living and development as well as in the host-parasite interactions, and drug target of SjIAP might be a potential for controlling schistosomiasis.
Peng
Jinbiao
J
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Key Laboratory of Animal Parasitology, Ministry of Agriculture, Shanghai, China.
Yang
Yanping
Y
Feng
Xingang
X
Cheng
Guofeng
G
Lin
Jiaojiao
J
D000595:Amino Acid Sequence; D000818:Animals; D061945:Caspase Inhibitors; D002460:Cell Line; D020869:Gene Expression Profiling; D015801:Helminth Proteins / Q000235:genetics / Q000502:physiology*; D006790:Host-Parasite Interactions; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D012549:Schistosoma japonicum / Q000235:genetics / Q000472:pathogenicity*; D016415:Sequence Alignment
D061945:Caspase Inhibitors; D015801:Helminth Proteins; D051034:Inhibitor of Apoptosis Proteins