[Study of nosocomial bacillary meningitis admitted in the Clinic of Infectious Diseases Iaşi on a 20 years period].
OBJECTIVE
To analyze the clinical features, etiology and evolution of nosocomial bacillary meningitis admitted to the Clinic of Infectious Diseases Iaşi between 1988 and 2007.


METHODS
The data were gathered from the archive of the Clinic of Infectious Diseases Iaşi. We studied the clinical and laboratory features of 28 cases of nosocomial bacillary meningitis admitted in the study period.


RESULTS
The development of nosocomial meningitis was subsequent to interventions on the central nervous system for hematoma, ventriculo-peritoneal shunts, tumors, rah anesthesia. The symptoms were fever, headache, stiff neck and vomiting. The etiological agents were: Acinetobacter spp--35.71%, Pseudomonas spp.--25%, Klebsiella pneumoniae--17.85%, Escherichia coli--14.28%, and mixed etiology, in 3.57% of the cases each. The treatment was according to their susceptibility, using systemic quinolones and ceftazidime or colymicin. The evolution was favorable in 13 patients and unfavorable in another 15.


CONCLUSIONS
Nosocomial meningitis caused by Gram negative bacilli is a severe infection, with diverse etiology, which raises therapeutical problems due to antibiotic resistance and a high mortality rate.
Logigan
Cătalina
C
Facultatea de Medicină, Clinica de Boli Infecţioase, Universitatea de Medicină si Farmacie "Gr. T. Popa" Iaşi.
Mihalache
Doina
D
Dorneanu
Olivia
O
Turcu
Tatiana
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002442:Ceftazidime / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003091:Colistin / Q000627:therapeutic use; D003428:Cross Infection / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004359:Drug Therapy, Combination; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D055819:Hospitals, Isolation; D006785:Hospitals, University; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008499:Medical Records; D016920:Meningitis, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D008875:Middle Aged; D009422:Nervous System Diseases / Q000601:surgery; D015363:Quinolones / Q000627:therapeutic use; D012189:Retrospective Studies; D012383:Romania; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D015363:Quinolones; D002442:Ceftazidime; D003091:Colistin