[Photosensitivity induced by metformin: a report of 3 cases].
BACKGROUND
Metformin is an oral antihypoglycemic drug. Its cutaneous side effects are rare and photosensitivity had not been reported.


OBJECTIVE
Case report.


METHODS
We report 3 cases (a man and two women) of photosensitivity induced by metformin, notified to the Tunisian National Centre of Pharmacovigilance. Onset of the reaction was respectively 22 days, 4 months and 4 years. Daily dose of metformin varied from 1 to 2 tablets. Cutaneous lesions were located in sun-exposed sites in all cases with extension to the back in one case. Lesions were eczematous in two cases and erythematous in one case. Lesions healed after stopping metformin in all cases with positive rechallenge in the 1st case.


CONCLUSIONS
In patient treated by metformin, occurrence of photosensitivity can be related to this drug.
Kastalli
Sarrah
S
Centre National de Pharmacovigilance, Tunis.
El Aïdli
Sihem
S
Chaabane
Amel
A
Amrani
Radhia
R
Daghfous
Riadh
R
Belkahia
Chalbi
C
D000368:Aged; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008297:Male; D008687:Metformin / Q000009:adverse effects*; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000139:chemically induced*
D007004:Hypoglycemic Agents; D008687:Metformin