title: Evaluation of a 4-aminopiperidine replacement in several series of CCR5 antagonists.
abstract: The bicyclic 5-amino-3-azabicyclo[3.3.0]octanes were shown to be effective replacements for the conformationally restricted 4-aminopiperidine ring found in several series of CCR5 antagonists.
authors.affiliation: Department of Medicinal Chemistry, Roche Palo Alto, Palo Alto, CA 94304, USA. remy.lemoine@roche.com
authors.forename: Rémy C
authors.initials: RC
authors.lastname: Lemoine
authors.forename: Ann C
authors.initials: AC
authors.lastname: Petersen
authors.forename: Lina
authors.initials: L
authors.lastname: Setti
authors.forename: Lijing
authors.initials: L
authors.lastname: Chen
authors.forename: Jutta
authors.initials: J
authors.lastname: Wanner
authors.forename: Andreas
authors.initials: A
authors.lastname: Jekle
authors.forename: Gabrielle
authors.initials: G
authors.lastname: Heilek
authors.forename: André
authors.initials: A
authors.lastname: deRosier
authors.forename: Changhua
authors.initials: C
authors.lastname: Ji
authors.forename: David M
authors.initials: DM
authors.lastname: Rotstein
mesh_terms: D065100:CCR5 Receptor Antagonists; D004353:Drug Evaluation, Preclinical; D008958:Models, Molecular; D010880:Piperidines / Q000737:chemistry*
chemical_list: C481395:4-aminopiperidine; D065100:CCR5 Receptor Antagonists; D010880:Piperidines