Evaluation of Chlorofusin, its Seven Chromophore Diastereomers, and Key Analogues.
Chlorofusin, its seven chromophore diastereomers, and key analogues were comparatively examined for inhibition of MDM2-p53 binding revealing that the chromophore, but not simple replacements, contributes significantly to the natural products properties, and that this contribution is independent of its relative and absolute stereochemistry.
Clark
Ryan C
RC
Department of Chemistry and the Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, California 92037, USA.
Lee
Sang Yeul
SY
Hwang
Inkyu
I
Searcey
Mark
M
Boger
Dale L
DL