A case of granulocyte-colony stimulating factor-producing hepatocellular carcinoma confirmed by immunohistochemistry.
Granulocyte-colony stimulating factor (G-CSF) is a naturally occurring glycoprotein that stimulates the proliferation and maturation of precursor cells in the bone marrow into fully differentiated neutrophils. Several reports of G-CSF-producing malignant tumors have been published, but scarcely any in the hepatobiliary system, such as in hepatocellular carcinoma (HCC). Here, we encountered a 69-yr-old man with a hepatic tumor who had received right hepatic resection. He showed leukocytosis of 25,450/microL along with elevated serum G-CSF. Histological examination of surgical samples demonstrated immunohistochemical staining for G-CSF, but not for G-CSF receptor. The patient survived without recurrence for four years, but ultimately passed away with multiple bone metastases. In light of the above, clinicians may consider G-CSF-producing HCC when encountering patients with leukocytosis and a hepatic tumor. More cases are needed to clarify the clinical picture of G-CSF-producing HCC.
Joshita
Satoru
S
Department of Internal Medicine, Matsumoto Medical Center, Matsumoto, Japan. joshita@shinshu-u.ac.jp
Nakazawa
Koh
K
Koike
Shoichiro
S
Kamijo
Atsushi
A
Matsubayashi
Kiyoshi
K
Miyabayashi
Hideharu
H
Furuta
Kiyoshi
K
Kitano
Kiyoshi
K
Yoshizawa
Kaname
K
Tanaka
Eiji
E
D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D017809:Fatal Outcome; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D016188:Receptors, Granulocyte Colony-Stimulating Factor / Q000378:metabolism
D016188:Receptors, Granulocyte Colony-Stimulating Factor; D016179:Granulocyte Colony-Stimulating Factor