title: Assessing a dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease) with 7T MR imaging.
abstract: Lhermitte-Duclos disease (LDD; dysplastic cerebellar gangliocytoma) is a rare hamartomatous lesion of the cerebellar cortex and this was first described in 1920. LDD is considered to be part of the autosomal-dominant phacomatosis and cancer syndrome Cowden disease (CS). We examined the brain of a 46-year-old man, who displayed the manifestations of CS, with 7 Tesla (T) and 1.5 T MRI and 1.5 T MR spectroscopy (1H-MRS). We discuss the possible benefits of employing ultrahigh-field MRI for making the diagnosis of this rare lesion.
authors.affiliation: Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Germany. ch.moenninghoff@uk-essen.de
authors.forename: Christoph
authors.initials: C
authors.lastname: Moenninghoff
authors.forename: Oliver
authors.initials: O
authors.lastname: Kraff
authors.forename: Marc
authors.initials: M
authors.lastname: Schlamann
authors.forename: Mark E
authors.initials: ME
authors.lastname: Ladd
authors.forename: Zaza
authors.initials: Z
authors.lastname: Katsarava
authors.forename: Elke R
authors.initials: ER
authors.lastname: Gizewski
mesh_terms: D002525:Cerebellar Cortex / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000150:complications / Q000473:pathology*; D003937:Diagnosis, Differential; D020234:Gait Ataxia / Q000209:etiology; D006223:Hamartoma Syndrome, Multiple / Q000150:complications / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D014717:Vertigo / Q000209:etiology