title: An exploratory analysis of the impact of family functioning on treatment for depression in adolescents.
abstract: This article explores aspects of family environment and parent-child conflict that may predict or moderate response to acute treatments among depressed adolescents (N = 439) randomly assigned to fluoxetine, cognitive behavioral therapy, their combination, or placebo. Outcomes were Week 12 scores on measures of depression and global impairment. Of 20 candidate variables, one predictor emerged: Across treatments, adolescents with mothers who reported less parent-child conflict were more likely to benefit than their counterparts. When family functioning moderated outcome, adolescents who endorsed more negative environments were more likely to benefit from fluoxetine. Similarly, when moderating effects were seen on cognitive behavioral therapy conditions, they were in the direction of being less effective among teens reporting poorer family environments.
authors.affiliation: Department of Psychology, Case Western Reserve University, Cleveland, OH 44106, USA. norah.feeny@case.edu
authors.forename: Norah C
authors.initials: NC
authors.lastname: Feeny
authors.forename: Susan G
authors.initials: SG
authors.lastname: Silva
authors.forename: Mark A
authors.initials: MA
authors.lastname: Reinecke
authors.forename: Steven
authors.initials: S
authors.lastname: McNulty
authors.forename: Robert L
authors.initials: RL
authors.lastname: Findling
authors.forename: Paul
authors.initials: P
authors.lastname: Rohde
authors.forename: John F
authors.initials: JF
authors.lastname: Curry
authors.forename: Golda S
authors.initials: GS
authors.lastname: Ginsburg
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Kratochvil
authors.forename: Sanjeev M
authors.initials: SM
authors.lastname: Pathak
authors.forename: Diane E
authors.initials: DE
authors.lastname: May
authors.forename: Betsy D
authors.initials: BD
authors.lastname: Kennard
authors.forename: Anne D
authors.initials: AD
authors.lastname: Simons
authors.forename: Karen C
authors.initials: KC
authors.lastname: Wells
authors.forename: Michele
authors.initials: M
authors.lastname: Robins
authors.forename: David
authors.initials: D
authors.lastname: Rosenberg
authors.forename: John S
authors.initials: JS
authors.lastname: March
mesh_terms: D000293:Adolescent; D002648:Child; D015928:Cognitive Behavioral Therapy / Q000379:methods*; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000523:psychology* / Q000628:therapy*; D004311:Double-Blind Method; D005190:Family / Q000523:psychology*; D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012107:Research Design; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D016037:Single-Blind Method; D012931:Social Environment; D016896:Treatment Outcome
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors