title: Studies on effect of piperine on oral bioavailability of ampicillin and norfloxacin.
abstract: Ampicillin and Norfloxacin are used to treat variety of bacterial infections. These two drugs have low oral bioavailability. Co-administration of Piperine (20 mg/kg), an alkaloid from Piper nigrum L. enhanced oral bioavailability of Ampicillin and Norfloxacin in animal model. This is reflected in various pharmacokinetic measurements like Cmax, Tmax, AUC and t(1/2) of the above antibiotics in animal model.
authors.affiliation: Department of Pharmacy, Annamalai University, Annamalainagar, Tamil Nadu, India. janakiraman_k06@yahoo.co.in
authors.forename: Kunchithapatham
authors.initials: K
authors.lastname: Janakiraman
authors.forename: Rajappan
authors.initials: R
authors.lastname: Manavalan