title: Impaired awareness of deficits and neuropsychiatric symptoms in early Alzheimer's disease: the Danish Alzheimer Intervention Study (DAISY).
abstract: Impaired awareness may be associated with increased neuropsychiatric symptoms in moderate to severe Alzheimer's disease, but relatively little is known about the association in early Alzheimer's disease. The aim of this study was to investigate if impaired awareness was associated with a higher frequency of neuropsychiatric symptoms in early Alzheimer's disease. In a Danish multicenter study, 321 patients with MMSE score > or =20 were evaluated. Patients with poor insight had significantly more neuropsychiatric symptoms than patients with full insight. When patients had increasing neuropsychiatric symptoms, caregivers reported higher levels of distress.
authors.affiliation: Memory Disorders Research Group, Department of Neurology, Neuroscience Centre, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. asmus.vogel@rh.regionh.dk
authors.forename: Asmus
authors.initials: A
authors.lastname: Vogel
authors.forename: Frans Boch
authors.initials: FB
authors.lastname: Waldorff
authors.forename: Gunhild
authors.initials: G
authors.lastname: Waldemar
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000377:Agnosia / Q000175:diagnosis* / Q000209:etiology*; D000544:Alzheimer Disease / Q000175:diagnosis / Q000523:psychology*; D001364:Awareness; D001921:Brain / Q000503:physiopathology*; D003718:Denmark; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D012042:Registries; D012720:Severity of Illness Index; D016037:Single-Blind Method; D011795:Surveys and Questionnaires