Total synthesis of adicardin.
The first synthesis of adicardin, a compound with anti-chronic renal failure activity isolated from Hydrangea macrophylla, has been described. The structures of the target compound and intermediates have been validated by MS, NMR, and identical with the natural product.
Li
Wei
W
Department of New Drug Research and Development, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Biosynthesis of Natural Products, Ministry of Health of PRC), Beijing, China.
Wu
Xiao-Feng
XF
Tong
Yuan-Feng
YF
Hao
Ling-Hua
LH
Yang
Qing-Yun
QY
Qi
Yan
Y
Wu
Song
S
D005960:Glucosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D031966:Hydrangea / Q000737:chemistry*; D007676:Kidney Failure, Chronic / Q000188:drug therapy*; D015394:Molecular Structure; D013237:Stereoisomerism; D014468:Umbelliferones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D005960:Glucosides; D014468:Umbelliferones; C547626:adicardin