IMRT-based optimization approaches for volumetric modulated single arc radiotherapy planning.
This paper reports on an evaluation of 5 RapidArc optimization approaches vs IMRT. This study includes 11 patients with adenocarcinoma of the prostate. Rectal Normal Tissue Complication Probability is used as a constraint in a dose escalation. RapidArc rectal NTCP's are lower than those of IMRT (p = 0.007). This allows a mean dose escalation of 2.1 Gy([0.7 Gy,3.5 Gy]).
Crijns
Wouter
W
Department of Radiotherapy, University Hospital Leuven, Leuven, Belgium. wouter.crijns@uz.kuleuven.be
Budiharto
Tom
T
Defraene
Gilles
G
Verstraete
Jan
J
Depuydt
Tom
T
Haustermans
Karin
K
Van den Heuvel
Frank
F
D000230:Adenocarcinoma / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011829:Radiation Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation* / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*