Ceramides and cerebrosides from the marine bryozoan Bugula neritina inhabiting South China Sea.
From the marine bryozoan Bugula neritina inhabiting South China Sea, a new ceramide named (2S,3R,4E)-2-(14'-methyl-pentadecanoylamino)-4-octadecene-l,3-diol (1) and a new cerebroside named 1-O-(beta-D-glucopyranosyl)-(2S,3R,4E)-2-(heptadecanoylamino)-4-octadecene-l,3-diol (6), together with one known ceramide (2) and three known cerebrosides (3, 4, and 5), were isolated. Their structures were deduced by extensive spectral analysis and chemical evidences. Compound 1 is branched with a methyl [-CH(CH(3))(2)] in the fatty acid moiety, which is a rare structural feature among ceramides. Compound 6 is a new cerebroside with 17 carbons in the fatty acid moiety, while 5 is a new natural product which was isolated from a natural origin for the first time.
Tian
Xiang-Rong
XR
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Tang
Hai-Feng
HF
Li
Yu-Shan
YS
Lin
Hou-Wen
HW
Ma
Ning
N
Zhang
Wei
W
Yao
Min-Na
MN
D000818:Animals; D002013:Bryozoa / Q000737:chemistry*; D002518:Ceramides / Q000737:chemistry / Q000302:isolation & purification*; D002554:Cerebrosides / Q000737:chemistry / Q000302:isolation & purification*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D013237:Stereoisomerism
C548609:(2S,3R,4E)-2-(14'-methyl-pentadecanoylamino)-4-octadecene-l,3-diol; C548608:1-O-(beta-D-glucopyranosyl)-(2S,3R,4E)-2-(heptadecanoylamino)-4-octadecene-l,3-diol; D002518:Ceramides; D002554:Cerebrosides