title: Identification of and human serum reactogenicity to neutralizing epitopes within the central unglycosylated region of the respiratory syncytial virus attachment protein.
abstract: We identified two overlapping neutralizing epitopes within residues 151 to 172 of the central unglycosylated region of the respiratory syncytial virus (RSV) attachment protein. In approximately 40% of hospitalized and outpatient adults infected with RSV subtype A, these contiguous residues are the target of > or =4-fold increases in IgG response between acute- and convalescent-phase sera.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 689, Rochester, NY 14642, USA. Yoshihiko_Murata@urmc.rochester.edu
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Murata
authors.forename: Paula M
authors.initials: PM
authors.lastname: Lightfoote
authors.forename: Ann R
authors.initials: AR
authors.lastname: Falsey
authors.forename: Edward E
authors.initials: EE
authors.lastname: Walsh
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D057134:Antibodies, Neutralizing / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D018604:Epitope Mapping; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008969:Molecular Sequence Data; D018113:Respiratory Syncytial Virus, Human / Q000276:immunology*; D014759:Viral Envelope Proteins / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D000939:Epitopes; D007074:Immunoglobulin G; D014759:Viral Envelope Proteins; C116204:attachment protein G