title: Primary ALK-positive anaplastic large cell lymphoma of the breast: a case report and review of the literature.
abstract: BACKGROUND
  Non-Hodgkin lymphomas of the breast are uncommon, which represent less than 1% of all breast malignancies and predominantly are of B-cell origin.
  
  
  METHODS
  In this report, a rare case of anaplastic lymphoma kinase (ALK)-positive anaplastic large T-cell lymphoma in the breast of a 16-year-old female without breast implant is described. The patient presented with a 3-month history of progressive right breast swelling and erythema. Clinically, inflammatory breast carcinoma was highly suspected. A tru-cut needle biopsy of the right breast demonstrated infiltration of tumoral cells around the breast lobules and soft tissue and also in angiolymphatic spaces. The immunohistochemical profile showed positivity for CD30 and ALK and confirmed the diagnosis of ALK-positive anaplastic large T-cell lymphoma of the breast.
  
  
  CONCLUSIONS
  Anaplastic large T-cell lymphoma of the breast is rare, and can clinically mimic inflammatory breast carcinoma in adolescence.
authors.affiliation: Department of Hematopathology, Dr Daneshbod Pathology Laboratory, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: Yahya
authors.initials: Y
authors.lastname: Daneshbod
authors.forename: Ahmad
authors.initials: A
authors.lastname: Oryan
authors.forename: Habib N
authors.initials: HN
authors.lastname: Khojasteh
authors.forename: Alireza
authors.initials: A
authors.lastname: Rasekhi
authors.forename: Nasrollah
authors.initials: N
authors.lastname: Ahmadi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mohammadianpanah
mesh_terms: D000293:Adolescent; D000077548:Anaplastic Lymphoma Kinase; D001943:Breast Neoplasms / Q000175:diagnosis / Q000201:enzymology / Q000473:pathology*; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis / Q000201:enzymology / Q000473:pathology*; D011505:Protein-Tyrosine Kinases / Q000032:analysis*; D020794:Receptor Protein-Tyrosine Kinases
chemical_list: D017730:Ki-1 Antigen; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases