title: Will knowledge of gene-based colorectal cancer disease risk influence quality of life and screening behavior? Findings from a population-based study.
abstract: BACKGROUND
  Several gene variants conveying a modestly increased risk for disease have been described for colorectal cancer. Patient acceptance of gene variant testing in clinical practice is not known. We evaluated the potential impact of hypothetical colorectal-cancer-associated gene variant testing on quality of life, health habits and cancer screening behavior.
  
  
  METHODS
  First-degree relatives of colorectal cancer patients and controls from the Seattle Colorectal Cancer Familial Registry were invited to participate in a web-based survey regarding testing for gene variants associated with colorectal cancer risk.
  
  
  RESULTS
  310 relatives and 170 controls completed the questionnaire. Quality of life for the hypothetical carrier state was modestly and nonsignificantly lower than current health after adjustment for sociodemographic and health factors. In the positive test scenario, 30% of respondents expressed willingness to change their diet, 25% to increase exercise, and 43% to start colorectal cancer screening. The proportions willing to modify these habits did not differ between groups.
  
  
  CONCLUSIONS
  Testing for gene variants associated with colorectal cancer risk may not influence quality of life, but may impact health habits and screening adherence. Changing behaviors as a result of testing may help to reduce cancer incidence and mortality, particularly among those at higher risk for colorectal cancer.
authors.affiliation: Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Wash. 98109, USA. sramsey@fhcrc.org
authors.forename: Scott
authors.initials: S
authors.lastname: Ramsey
authors.forename: David
authors.initials: D
authors.lastname: Blough
authors.forename: Cara
authors.initials: C
authors.lastname: McDermott
authors.forename: Lauren
authors.initials: L
authors.lastname: Clarke
authors.forename: Robin
authors.initials: R
authors.lastname: Bennett
authors.forename: Wylie
authors.initials: W
authors.lastname: Burke
authors.forename: Polly
authors.initials: P
authors.lastname: Newcomb
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D055088:Early Detection of Cancer; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D015438:Health Behavior; D006801:Humans; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D009154:Mutation / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics*; D011788:Quality of Life; D012042:Registries; D018570:Risk Assessment; D011795:Surveys and Questionnaires; D014861:Washington / Q000453:epidemiology; D055815:Young Adult
chemical_list: D009363:Neoplasm Proteins