title: In vivo anthelmintic activity of crude extracts of Radix angelicae pubescentis, Fructus bruceae, Caulis spatholobi, Semen aesculi, and Semen pharbitidis against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus).
abstract: In search of a natural antiparasitic, in vivo anthelmintic activity of petroleum ether, chloroform, ethyl acetate, methanol, and aqueous extracts of Angelica pubescens roots (Radix angelicae pubescentis), Brucea javanica fruits (Fructus bruceae), Spatholobus suberectus stems (Caulis spatholobi), Aesculus chinensis Bge. seeds (Semen aesculi), and Pharbitis purpurea (L.) Voigt seeds (Semen pharbitidis) were tested against Dactylogyrus intermedius (Monogenea) in goldfish (Carassius auratus). Among the extracts tested, the methanolic and aqueous extracts of S. aesculi were observed to be more efficient than the other plant extracts with EC(50) and EC(90) values of 5.23 and 7.33 mg/L and 6.48 and 12.29 mg/L after 48 h, respectively, followed by methanolic extracts of Fructus bruceae, Radix angelicae pubescentis, Caulis spatholobi, and Semen pharbitidis with EC(50) 49.96, 57.45, 64.92, and 309.47 mg/L. The methanolic and aqueous extracts of S. aesculi exhibited potential results and can be exploited as a preferred natural antiparasitic for the control of D. intermedius.
authors.affiliation: Northwest A&F University, Xinong Road 22nd, Yangling, Shaanxi, 712100, China.
authors.forename: You-Tao
authors.initials: YT
authors.lastname: Liu
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
authors.forename: Gao-Xue
authors.initials: GX
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Han
authors.forename: Yong
authors.initials: Y
authors.lastname: Wang
authors.forename: Yong-Hua
authors.initials: YH
authors.lastname: Wang
mesh_terms: D000818:Animals; D000980:Antiplatyhelmintic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D045424:Complex Mixtures / Q000302:isolation & purification / Q000627:therapeutic use*; D029624:Ferns / Q000737:chemistry*; D005393:Fish Diseases / Q000188:drug therapy* / Q000469:parasitology; D005638:Fruit / Q000737:chemistry; D006054:Goldfish / Q000469:parasitology*; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010986:Platyhelminths / Q000187:drug effects; D012639:Seeds / Q000737:chemistry; D014201:Trematode Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*
chemical_list: D000980:Antiplatyhelmintic Agents; D045424:Complex Mixtures