Drug-induced eosinophilic pneumonia with pulmonary alveolar hemorrhage caused by benzbromarone.
A 51-year-old man was admitted to our hospital with cough, hemosputum, dyspnea and chest pain. Chest high-resolution computed tomography (HRCT) revealed diffuse ground-glass opacities in both lungs with peripheral predominance. Bronchoalveolar lavage fluid was fresh-bloody and analysis indicated an increase in the eosinophil proportion. Benzbromarone-induced lymphocyte stimulation test was positive. Therefore, the patient was diagnosed as having drug-induced eosinophilic pneumonia with pulmonary alveolar hemorrhage caused by benzbromarone. After discontinuation of benzbromarone and administration of corticosteroids, chest HRCT images and respiratory manifestation improved. Here, we report this rare case of benzbromarone-induced eosinophilic pneumonia with pulmonary alveolar hemorrhage.
Hara
Atsuko
A
Second Department of Internal Medicine, Nagasaki University School of Medicine.
Mukae
Hiroshi
H
Hara
Shintaro
S
Amenomori
Misato
M
Ishimoto
Hiroshi
H
Kakugawa
Tomoyuki
T
Fujita
Hanako
H
Sakamoto
Noriho
N
Ishii
Hiroshi
H
Ishimatsu
Yuji
Y
Kohno
Shigeru
S
D001553:Benzbromarone / Q000009:adverse effects* / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid; D006073:Gout / Q000188:drug therapy; D006470:Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008171:Lung Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed; D014528:Uricosuric Agents / Q000009:adverse effects / Q000627:therapeutic use
D014528:Uricosuric Agents; D001553:Benzbromarone