title: Childhood obesity and survival after in-hospital pediatric cardiopulmonary resuscitation.
abstract: OBJECTIVE
  We hypothesized that childhood obesity would be associated with decreased likelihood of survival to hospital discharge after in-hospital, pediatric cardiopulmonary resuscitation (CPR).
  
  
  METHODS
  We reviewed 1477 consecutive, pediatric, CPR index events (defined as the first CPR event during a hospitalization in that facility for a patient <18 years of age) reported to the American Heart Association National Registry of Cardiopulmonary Resuscitation between January 2000 and July 2004. The primary outcome was survival to hospital discharge. A total of 1268 index subjects (86%) with complete registry data were included for analysis. Children were classified as obese (> or =95th weight-for-length percentile if <2 years of age or > or =95th BMI-for-age percentile if > or =2 years of age) or underweight (<5th weight-for-length percentile if <2 years of age or <5th BMI-for-age percentile if > or =2 years of age), with adjustment for gender.
  
  
  RESULTS
  Obesity was noted for 213 (17%) of 1268 subjects and underweight for 571 (45%) of 1268 subjects. Obesity was more likely to be associated with male gender, noncardiac medical illness, and cancer and inversely associated with heart failure. Underweight was more likely to be associated with male gender, cardiac surgery, and prematurity and inversely associated with age and cancer. Self-reported, process-of-care, CPR quality was generally worse for obese children. With adjustment for important potential confounding factors, obesity was independently associated with worse odds of event survival (adjusted odds ratio: 0.58 [95% confidence interval: 0.35-0.76]) and survival to hospital discharge (adjusted odds ratio: 0.62 [95% confidence interval: 0.38-0.93]) after in-hospital, pediatric CPR. Underweight was not associated with worse outcomes.
  
  
  CONCLUSIONS
  Childhood obesity is associated with a lower rate of survival to hospital discharge after in-hospital, pediatric CPR.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA. srinivasan@email.chop.edu
authors.forename: Vijay
authors.initials: V
authors.lastname: Srinivasan
authors.forename: Vinay M
authors.initials: VM
authors.lastname: Nadkarni
authors.forename: Mark A
authors.initials: MA
authors.lastname: Helfaer
authors.forename: Scott M
authors.initials: SM
authors.lastname: Carey
authors.forename: Robert A
authors.initials: RA
authors.lastname: Berg
mesh_terms: D016887:Cardiopulmonary Resuscitation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006323:Heart Arrest / Q000150:complications / Q000401:mortality* / Q000628:therapy*; D006801:Humans; D007223:Infant; D008297:Male; D009765:Obesity / Q000150:complications*; D010351:Patient Discharge; D011446:Prospective Studies; D012307:Risk Factors; D015996:Survival Rate