A UVB wavelength dependency for local suppression of recall immunity in humans demonstrates a peak at 300 nm.
UVB radiation is a potent environmental carcinogen that not only causes mutations in the skin but also profoundly suppresses skin immune responses. Although this UVB-induced suppression of antitumor immunity has a key role in skin cancer development, the wavelengths within UVB causing greatest in vivo immunosuppression in humans are as yet unknown. We have identified a wavelength dependency for immunosuppression in humans across the UVB spectrum. We established linear dose-response curves for UV-induced local suppression of recall contact hypersensitivity responses at four wavelengths between 289 and 322 nm and found peak immune suppressive effectiveness at 300 nm and no detectable suppression at 322 nm within a physiologically relevant dose range.
Matthews
Yasmin J
YJ
Discipline of Dermatology, Bosch Institute, The University of Sydney at Royal Prince Alfred Hospital, Missenden Road, Sydney, Camperdown, NSW 2050, Australia.
Halliday
Gary M
GM
Phan
Tai A
TA
Damian
Diona L
DL
D000328:Adult; D016022:Case-Control Studies; D003877:Dermatitis, Contact / Q000276:immunology; D004307:Dose-Response Relationship, Radiation; D004890:Erythema / Q000139:chemically induced / Q000276:immunology*; D005260:Female; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000528:radiation effects*; D007108:Immune Tolerance / Q000276:immunology / Q000528:radiation effects*; D016014:Linear Models; D009532:Nickel / Q000009:adverse effects; D010328:Patch Tests; D011855:Radiodermatitis / Q000276:immunology*; D012867:Skin / Q000276:immunology / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*
D009532:Nickel