title: Prevalence of low bone mineral density in children and adolescents with celiac disease under treatment.
abstract: OBJECTIVE
  Low bone mineral density may be a finding among children and adolescents with celiac disease, including those undergoing treatment with a gluten-free diet, but the data are contradictory. The aim of this study was to determine the frequency of bone mineral density abnormalities in patients on a gluten-free diet, considering age at diagnosis and duration of dietary treatment.
  
  
  METHODS
  Cross-sectional prevalence study at the Pediatric Gastroenterology Outpatient Clinic of Instituto Materno Infantil Professor Fernando Figueira.
  
  
  METHODS
  Thirty-one patients over five years of age with celiac disease and on a gluten-free diet were enrolled. Bone mineral density (in g/cm(2)) was measured in the lumbar spine and whole body using bone densitometry and categorized using the criteria of the International Society for Clinical Densitometry, i.e. low bone mineral density for chronological age < -2.0 Z-scores. Age at diagnosis and duration of dietary treatment were confirmed according to the date of starting the gluten-free diet.
  
  
  RESULTS
  Low bone density for chronological age was present in 3/31 patients in the lumbar spine and 1/31 in the whole body (also with lumbar spine abnormality). At diagnosis, three patients with low bone mineral density for the chronological age were more than 7.6 years old. These patients had been on a gluten-free diet for six and seven months and 3.4 years.
  
  
  CONCLUSIONS
  Pediatric patients with celiac disease on long-term treatment are at risk of low bone mineral density. Early diagnosis and long periods of gluten-free diet are directly implicated in bone density normalization.
authors.affiliation: Division of Pediatric Gastroenterology, Universidade Federal de Pernambuco, Recife, Pernambuco, Brazil. eugenia.motta@gmail.com
authors.forename: Maria Eugênia Farias Almeida
authors.initials: ME
authors.lastname: Motta
authors.forename: Maria Eduarda Nóbrega de
authors.initials: ME
authors.lastname: Faria
authors.forename: Gisélia Alves Pontes da
authors.initials: GA
authors.lastname: Silva
mesh_terms: D000293:Adolescent; D015519:Bone Density / Q000502:physiology; D001851:Bone Diseases, Metabolic / Q000453:epidemiology* / Q000209:etiology; D002446:Celiac Disease / Q000178:diet therapy* / Q000503:physiopathology; D002648:Child; D003430:Cross-Sectional Studies; D055050:Diet, Gluten-Free / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D013997:Time Factors