title: Meta-analysis of BDNF Val66Met polymorphism association with treatment response in patients with major depressive disorder.
abstract: The aim of our meta-analysis was to assess the association between BDNF Val66Met polymorphism and treatment response in patients with MDD. 8 studies that included data from 1115 subjects were identified. We tested two phenotypes: response rate and remission rate. OR was used as a measure of the effect of the association in a fixed/random effect model. Meta-analysis was performed for genotypes Met/Met versus Val/Val, Val/Met versus Val/Val, Met/Met versus Val/Met, Val/Met+Met/Met versus Val/Val, Met/Met versus Val/Val+Val/Met, and Met allele versus Val allele. When all groups were pooled, a significant association of Val/Met genotype and increased response rate was found in comparison to Val/Val in overall population (OR=1.66, 95%CI=1.07-2.57, P=0.02). In the subgroup analysis, similar result was shown in Asian population (OR=1.83, 95%CI=1.03-3.26, P=0.04), but not in Caucasian population. We didn't observe a significant association of BDNF Val66Met polymorphism with remission rate. This meta-analysis demonstrates the association between BDNF Val66Met polymorphism and treatment response in patients with MDD, and Val66Met heterozygous patients have a better response rate in comparison to Val/Val homozygote patients, especially in Asian population.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 230032, Hefei, China.
authors.forename: Yan-Feng
authors.initials: YF
authors.lastname: Zou
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
authors.forename: Xiao-Liang
authors.initials: XL
authors.lastname: Feng
authors.forename: Hong
authors.initials: H
authors.lastname: Su
authors.forename: Fa-Ming
authors.initials: FM
authors.lastname: Pan
authors.forename: Fang-Fang
authors.initials: FF
authors.lastname: Liao
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D044466:Asian People / Q000235:genetics; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002986:Clinical Trials as Topic; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D017594:Publication Bias; D044465:White People / Q000235:genetics
chemical_list: D000928:Antidepressive Agents; D019208:Brain-Derived Neurotrophic Factor