Transient abnormal myelopoiesis associated with Down syndrome presenting as severe hydrops fetalis: a case report.
We present a case of transient abnormal myelopoiesis (TAM) presenting as non-immune fetal hydrops (NIHF). Hydrops fetalis (HF) is a condition associated with very high perinatal mortality, especially when no treatable cause, such as fetal anaemia, exists. In fetuses prior to 24 weeks with NIHF, a chromosomal anomaly is a common association. TAM is a leukaemic condition, almost entirely limited to children with Down syndrome. The presentation of TAM prenatally is unusual but cases may present ultrasonographically with NIHF and associated fetal hepatosplenomegaly. We report a case presenting in this manner with NIHF detected at 29 weeks' gestation and discuss the subsequent diagnosis and management of in utero TAM.
Malin
G L
GL
School of Clinical and Experimental Medicine, University of Birmingham, Birmingham Women's Foundation Trust, Edgbaston, Birmingham, UK.
Kilby
Mark D
MD
Velangi
M
M
D000328:Adult; D004314:Down Syndrome / Q000175:diagnosis* / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015160:Hydrops Fetalis / Q000175:diagnosis* / Q000628:therapy; D007231:Infant, Newborn; D038042:Myelopoiesis; D011247:Pregnancy; D011263:Pregnancy Trimester, Third