A novel norditerpenoid alkaloid from Aconitum macrorhynchum.
A novel norditerpenoid alkaloid, macrorhynine C (1), together with three known compounds, was isolated from Aconitum macrorhynchum. The structure of the new alkaloid was elucidated on the basis of spectral analyses as (1alpha,6alpha,16beta)-3-hydroxy-8-acetyloxy-13-hydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-19-ene-aconitan-14-yl 4-methoxybenzoate (1). The novel compound was found to contain the rare C(19) = N azomethine group. Compounds 2-4 were obtained from this species for the first time.
Yang
Li-Juan
LJ
Key Laboratory of Medicinal Chemistry for Natural Resources, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, China.
Luo
Yi-Ping
YP
Chen
Wen
W
Zhao
Jing-Feng
JF
Yang
Xiao-Dong
XD
Li
Liang
L
D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D004224:Diterpenes; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D013237:Stereoisomerism
D000470:Alkaloids; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C547644:macrorhynine C