title: Promoting implantation by local injury to the endometrium.
abstract: OBJECTIVE
  To evaluate the association between endometrial injury, implantation and pregnancy rate.
  
  
  METHODS
  We performed a literature search using the keywords endometrial injury, local endometrial injury, endometrial biopsy, endometrial receptivity, implantation, in vitro fertilization, and implantation failure and conducted the search in Medline, EMBASE, and Cochrane Database of systematic reviews.
  
  
  METHODS
  None.
  
  
  METHODS
  None.
  
  
  METHODS
  None.
  
  
  METHODS
  None.
  
  
  RESULTS
  Clinical and basic science data regarding the association between endometrial injury and improved implantation rate are limited. However, current evidence suggests that endometrial injury before IVF among women with previous repeated IVF failure is associated with increased rates of implantation, clinical pregnancy, and live birth.
  
  
  CONCLUSIONS
  Endometrial injury may have a beneficial role in implantation and improve the pregnancy rate. However, there are still many unanswered question including patients selection, timing, technique and number of endometrial biopsies needed.
authors.affiliation: Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Almog
authors.forename: Einat
authors.initials: E
authors.lastname: Shalom-Paz
authors.forename: Daniel
authors.initials: D
authors.lastname: Dufort
authors.forename: Togas
authors.initials: T
authors.lastname: Tulandi
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000209:etiology; D000818:Animals; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D010064:Embryo Implantation / Q000502:physiology*; D004717:Endometrium / Q000293:injuries* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D011247:Pregnancy; D011256:Pregnancy Outcome