title: Hepatic steatosis associated with increased central body fat by dual-energy X-ray absorptiometry and uncontrolled HIV in HIV/hepatitis C co-infected persons.
abstract: OBJECTIVE
  To evaluate the relationship between regional body composition and liver disease (fibrosis or steatosis) in HIV/HCV co-infected individuals.
  
  
  METHODS
  Whole body dual-energy X-ray absorptiometry (DXA) was performed in 173 HIV/HCV co-infected persons within 12 months of a liver biopsy. Significant fibrosis was defined as a METAVIR stage greater than 1. Steatosis was graded as: 0, none; 1, steatosis involving less than 5% of hepatocytes; 2, 5-29%; 3, 30-60%; 4 greater than 60%, and was defined as more than 0. Poisson regression with robust variance was used to estimate prevalence ratios of the outcome measures.
  
  
  RESULTS
  The population was 62% male and 84% black with a median body mass index of 25.2 kg/m (interquartile range 22.5, 29.3 kg/m). No differences in regional body fat or fat distribution were observed in 42 patients with significant fibrosis compared to others with less fibrosis. However, the 77 individuals (45%) with steatosis had greater central fat than those without steatosis [prevalence ratio 1.04 per kg trunk fat; 95% confidence interval (CI) 1.04, 1.11], after adjusting for hepatic fibrosis (prevalence ratio 1.77; 95% CI 1.29, 2.42), uncontrolled HIV replication (viral load >400 copies/ml) (prevalence ratio 1.57; 95% CI 1.12, 2.22), age, sex, race and diabetes mellitus.
  
  
  CONCLUSIONS
  In HIV/HCV co-infected individuals, measures of regional body fat or fat distribution were not associated with hepatic fibrosis. In contrast, increased central adiposity by DXA, as well as concomitant fibrosis and uncontrolled HIV, were associated with hepatic steatosis. The extent to which weight loss and effective antiretroviral therapy can reduce the risk of steatosis deserves further investigation.
authors.affiliation: Johns Hopkins School of Medicine, USA. tbrown27@jhmi.edu
authors.forename: Todd T
authors.initials: TT
authors.lastname: Brown
authors.forename: Shruti H
authors.initials: SH
authors.lastname: Mehta
authors.forename: Catherine
authors.initials: C
authors.lastname: Sutcliffe
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Higgins
authors.forename: Michael S
authors.initials: MS
authors.lastname: Torbenson
authors.forename: Richard D
authors.initials: RD
authors.lastname: Moore
authors.forename: David L
authors.initials: DL
authors.lastname: Thomas
authors.forename: Mark S
authors.initials: MS
authors.lastname: Sulkowski
mesh_terms: D015502:Absorptiometry, Photon; D000273:Adipose Tissue / Q000473:pathology*; D000328:Adult; D005234:Fatty Liver / Q000209:etiology / Q000473:pathology* / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000473:pathology* / Q000821:virology; D006526:Hepatitis C / Q000150:complications / Q000473:pathology* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D019562:Viral Load