title: Nephrotic syndrome from the genetic point of view.
abstract: Nephrotic syndrome, an entity described at the beginning of the 20th century, has still an unclear pathophysiology, genetic and immunologic factors being incriminated. Here we report three cases of nephrotic syndrome with genetic involvement. The article presented tremendous progress that have been made over the past few years in enhancing our understanding of the slit-diaphragm and podocyte biology and genetics involvement in nephrotic syndrome.
authors.affiliation: IVth Pediatric Clinic, School of Medicine,"Gr.T. Popa" University of Medicine and Pharmacy, Iaşi.
authors.forename: Florentina
authors.initials: F
authors.lastname: Cucer
authors.forename: Cristina
authors.initials: C
authors.lastname: Rusu
authors.forename: R
authors.initials: R
authors.lastname: Muller
authors.forename: Mihaela
authors.initials: M
authors.lastname: Munteanu
authors.forename: Doina
authors.initials: D
authors.lastname: Mihăilă
authors.forename: Ingrith
authors.initials: I
authors.lastname: Miron
authors.forename: O
authors.initials: O
authors.lastname: Brumariu
mesh_terms: D002675:Child, Preschool; D003241:Consanguinity; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D007438:Introns; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D009404:Nephrotic Syndrome / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D017384:Sequence Deletion / Q000235:genetics
chemical_list: D008565:Membrane Proteins; C113267:nephrin