title: Decreased susceptibility to teicoplanin and vancomycin in coagulase-negative Staphylococci isolated from orthopedic-device-associated infections.
abstract: We studied 315 coagulase-negative Staphylococcus strains recovered prospectively during 240 surgical procedures (206 subjects) from proven or suspected device-associated bone and joint infections. Sixteen strains (5.1%) had decreased susceptibility to glycopeptides: 15 (12 S. epidermidis strains, 2 S. capitis strains, and 1 S. haemolyticus strain) to teicoplanin alone (MIC of 16 mg/liter, n = 9; MIC of 32 mg/liter, n = 6) and one (S. epidermidis) to both teicoplanin and vancomycin (MIC, 16 and 8 mg/liter, respectively). Decreased susceptibility to teicoplanin was more prevalent in "infecting" strains (i.e., strains recovered from >/=2 distinct intraoperative samples) than in "contaminants" (i.e., strains not fulfilling this criterion) (8.1% [12/149] versus 2.4% [4/166], respectively [P = 0.022]). One hundred percent (13/13) of S. epidermidis strains with decreased susceptibility to teicoplanin were resistant to methicillin (versus 112/173 [64.7%] for S. epidermidis strains susceptible to teicoplanin; P = 0.021).
authors.affiliation: EA3647, Université de Versailles Saint-Quentin-en-Yvelines, Garches.
authors.forename: Julie
authors.initials: J
authors.lastname: Cremniter
authors.forename: Asma
authors.initials: A
authors.lastname: Slassi
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Quincampoix
authors.forename: Valérie
authors.initials: V
authors.lastname: Sivadon-Tardy
authors.forename: Thomas
authors.initials: T
authors.lastname: Bauer
authors.forename: Raphaël
authors.initials: R
authors.lastname: Porcher
authors.forename: Alain
authors.initials: A
authors.lastname: Lortat-Jacob
authors.forename: Philippe
authors.initials: P
authors.lastname: Piriou
authors.forename: Thierry
authors.initials: T
authors.lastname: Judet
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Herrmann
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Gaillard
authors.forename: Martin
authors.initials: M
authors.lastname: Rottman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003030:Coagulase / Q000096:biosynthesis; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000382:microbiology*; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology; D017334:Teicoplanin / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D003030:Coagulase; D017334:Teicoplanin; D014640:Vancomycin