title: Efficacy of tin-containing solutions on erosive mineral loss in enamel and dentine in situ.
abstract: The addition of tin to mouth rinses is, at least in vitro, a promising strategy for symptomatic therapy of dental erosion. The aim of this study was to evaluate the in situ efficacy of an experimental tin-containing fluoride solution on erosive tissue loss in human enamel and dentine. The study was a three-cell (7 days each) crossover design involving eight healthy participants. Samples were mounted on buccal shields of mandibular mouth appliances, which were worn for 24 h except during meals and drinks. Specimens were demineralised extraorally with 0.05 M citric acid (pH 2.3) for 6 × 5 min daily and were treated with test solutions intraorally once per day for 30 s after the first demineralisation. Three solutions were used: placebo (negative control), a commercially available tin- and fluoride-containing (SnF(2)) mouth rinse (positive control, 409 ppm Sn(2+), 250 ppm F(-), pH 4.2) and an experimental solution (pH 4.5) containing 1,900 ppm Sn(2+) (SnCl(2)) and 1,000 ppm F(-) (AmF/NaF). Tissue loss (micrometre) was determined profilometrically. In enamel, tissue loss was 54.8 ± 8.6 in the placebo, 24.5 ± 14.4 in the positive control and 9.7 ± 4.1 in the experimental solution group. The respective values for dentine were 48.5 ± 13.0 in the placebo, 32.8 ± 9.6 in the positive control and 26.2 ± 6.7 in the experimental solution group. The experimental solution was notably effective for enamel but was less effective for dentine. The positive control solution was less effective than the experimental solution; its effects for enamel and dentine were similar.
authors.affiliation: Department of Conservative and Preventive Dentistry, Dental Clinic of the Justus Liebig University, Schlangenzahl 14, 35392 Giessen, Germany. nadine.schlueter@dentist.med.uni-giessen.de
authors.forename: Nadine
authors.initials: N
authors.lastname: Schlueter
authors.forename: Joachim
authors.initials: J
authors.lastname: Klimek
authors.forename: Carolina
authors.initials: C
authors.lastname: Ganss
mesh_terms: D000588:Amines / Q000494:pharmacology / Q000627:therapeutic use; D018592:Cross-Over Studies; D003743:Dental Enamel / Q000187:drug effects; D003804:Dentin / Q000187:drug effects; D003959:Diamines / Q000494:pharmacology / Q000627:therapeutic use; D004311:Double-Blind Method; D004338:Drug Combinations; D005459:Fluorides / Q000494:pharmacology / Q000627:therapeutic use; D005460:Fluorides, Topical / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009067:Mouthwashes / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D011446:Prospective Studies; D012969:Sodium Fluoride / Q000494:pharmacology / Q000627:therapeutic use; D018709:Statistics, Nonparametric; D017971:Tin Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D014002:Tin Fluorides / Q000494:pharmacology / Q000627:therapeutic use*; D014077:Tooth Erosion / Q000188:drug therapy*; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: D000588:Amines; D003959:Diamines; D004338:Drug Combinations; D005460:Fluorides, Topical; D009067:Mouthwashes; D017971:Tin Compounds; D014002:Tin Fluorides; C094808:amine fluoride solution; C059813:Meridol; C023599:stannous chloride; C495399:Olaflur; D012969:Sodium Fluoride; D005459:Fluorides