title: Decreased plasma levels of darunavir/ritonavir in a vertically infected pregnant woman carrying multiclass-resistant HIV type-1.
abstract: We report a case of a vertically infected woman treated with darunavir/ritonavir plus a standard backbone before pregnancy. The analysis of darunavir/ritonavir concentrations in peripheral maternal plasma throughout pregnancy, as well as in umbilical cord blood at delivery, showed low levels of darunavir in the mother and limited transfer across the placenta.
authors.affiliation: Department of Infectious Diseases, Catholic University, Rome, Italy. carmenpinnetti@yahoo.it
authors.forename: Carmela
authors.initials: C
authors.lastname: Pinnetti
authors.forename: Enrica
authors.initials: E
authors.lastname: Tamburrini
authors.forename: Enzo
authors.initials: E
authors.lastname: Ragazzoni
authors.forename: Andrea
authors.initials: A
authors.lastname: De Luca
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Navarra
mesh_terms: D000069454:Darunavir; D024921:Drug Resistance, Multiple, Viral; D004359:Drug Therapy, Combination; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy* / Q000635:transmission; D017320:HIV Protease Inhibitors / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000188:drug therapy* / Q000821:virology; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D019438:Ritonavir / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D013449:Sulfonamides / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D017320:HIV Protease Inhibitors; D012367:RNA, Viral; D013449:Sulfonamides; D019438:Ritonavir; D000069454:Darunavir