Swimming into the future of drug discovery: in vivo chemical screens in zebrafish.
In recent years in vivo chemical screening in zebrafish has emerged as a rapid and efficient method to identify lead compounds that modulate specific biological processes. By performing primary screening in vivo, the bioactivity, toxicity, and off-target side effects are determined from the onset of drug development. A recent study demonstrates that in vivo screening can be used successfully to perform structure-activity relationship (SAR) studies. This work validates the zebrafish as an effective model for not only drug discovery but also drug optimization.
Bowman
Teresa V
TV
Stem Cell Program and Division of Hematology and Oncology, Children's Hospital Boston and Howard Hughes Medical Institute, 300 Longwood Avenue, Boston, Massachusetts 02115, USA.
Zon
Leonard I
LI
D000818:Animals; D055808:Drug Discovery / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D054852:Small Molecule Libraries; D015027:Zebrafish / Q000378:metabolism*
D054852:Small Molecule Libraries