title: Cervical remodeling during pregnancy and parturition.
abstract: Appropriate and timely cervical remodeling is key for successful birth. Premature cervical opening can result in preterm birth which occurs in 12.5% of pregnancies. Research focused on the mechanisms of term and preterm cervical remodeling is essential to prevent prematurity. This review highlights recent findings that better define molecular processes driving progressive disorganization of the cervical extracellular matrix. This includes studies that redefine the role of immune cells and identify diverse functions of the cervical epithelia and hyaluronan in remodeling. New investigations proposing that infection-induced premature cervical remodeling is distinct from the normal process are presented. Recent advances in our understanding of term and preterm cervical remodeling provide new directions for investigation and compel investigators to reevaluate currently accepted models.
authors.affiliation: Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, TX 75235-9032, USA.
authors.forename: Brenda
authors.initials: B
authors.lastname: Timmons
authors.forename: Meredith
authors.initials: M
authors.lastname: Akins
authors.forename: Mala
authors.initials: M
authors.lastname: Mahendroo
mesh_terms: D000818:Animals; D020070:Cervical Ripening / Q000502:physiology*; D002584:Cervix Uteri / Q000033:anatomy & histology / Q000502:physiology*; D005260:Female; D006801:Humans; D007747:Labor Stage, First / Q000502:physiology*; D036801:Parturition / Q000502:physiology*; D011247:Pregnancy / Q000502:physiology*