Different fetal-neonatal outcomes in siblings born to a mother with Graves-Basedow disease after total thyroidectomy: a case series.
BACKGROUND
We describe three different fetal or neonatal outcomes in the offspring of a mother who had persistent circulating thyrotropin receptor antibodies despite having undergone a total thyroidectomy several years before.


METHODS
The three different outcomes were an intrauterine death, a mild and transient fetal and neonatal hyperthyroidism and a severe fetal and neonatal hyperthyroidism that required specific therapy.


CONCLUSIONS
The three cases are interesting because of the different outcomes, the absence of a direct correlation between thyrotropin receptor antibody levels and clinical signs, and the persistence of thyrotropin receptor antibodies several years after a total thyroidectomy.
Zuppa
Antonio Alberto
AA
Department of Pediatrics, Division of Neonatology, Catholic University of the Sacred Heart, Largo Agostino Gemelli 8, 00168 Rome, Italy. zuppaaa@rm.unicatt.it.
Sindico
Paola
P
Perrone
Sabrina
S
Carducci
Chiara
C
Antichi
Eleonora
E
Alighieri
Giovanni
G
Cota
Francesco
F
Papacci
Patrizia
P
De Carolis
Maria Pia
MP
Romagnoli
Costantino
C
Cardiello
Valentina
V