High cerebrospinal fluid antioxidants and interleukin 8 are protective of hypoxic brain damage in newborns.
The objective was to explain the discrepancy in the development of hypoxic ischemic brain injury (HIE) in some asphyxiated newborns rather than others. Forty newborns were classified according to their cerebrospinal neuron-specific-enolase (CSF-NSE) levels on their 5th-day of life; group 1 with low-NSE (n = 25). The remaining 15 newborns had high-NSE and were further divided into a group with no HIE (n = 10, group 2) and another with HIE (n = 5, group 3). CSF-NSE, total-hydroperoxide (TH), biological-antioxidant-potentials (BAPs), 12 cytokines and erythropoietin (EPO) were measured. The TH/BAP gave the oxidative-stress-index (OSI). The BAPs of serial dilutions of three types of EPO were tested. CSF-NSE and TH and mean OSIs were higher in group 3. IL-8 and mean BAPs were higher in group 2 than in group 1. EPO was less detected in group 3. Serial EPO dilutions correlated with their BAPs. Compensatory antioxidants and IL-8 elevation could be protective of perinatal asphyxic brain injury. Antioxidative effect of EPO could be neuroprotective.
Hussein
Mohamed Hamed
MH
Department of Pediatric Surgery and Liver Transplantation, Fujita Health University School of Medicine, Aichi, Japan. hamed@fujita-hu.ac.jp
Daoud
Ghada A
GA
Kakita
Hiroki
H
Kato
Shin
S
Goto
Tatenobu
T
Kamei
Michi
M
Goto
Kenji
K
Nobata
Masanori
M
Ozaki
Yasuhiko
Y
Ito
Tetsuya
T
Fukuda
Sumio
S
Kato
Ineko
I
Suzuki
Satoshi
S
Sobajima
Hisanori
H
Hara
Fujio
F
Hashimoto
Takashi
T
Togari
Hajime
H
D000975:Antioxidants / Q000378:metabolism*; D001212:Asialoglycoproteins / Q000378:metabolism; D001238:Asphyxia Neonatorum / Q000134:cerebrospinal fluid / Q000150:complications* / Q000276:immunology; D004921:Erythropoietin / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid / Q000378:metabolism; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000134:cerebrospinal fluid; D002534:Hypoxia, Brain / Q000134:cerebrospinal fluid / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D007231:Infant, Newborn; D016209:Interleukin-8 / Q000134:cerebrospinal fluid*; D008297:Male; D018384:Oxidative Stress; D010751:Phosphopyruvate Hydratase / Q000134:cerebrospinal fluid; D011994:Recombinant Proteins; D015854:Up-Regulation
D000975:Antioxidants; D001212:Asialoglycoproteins; C508606:CXCL8 protein, human; D016209:Interleukin-8; D011994:Recombinant Proteins; C500605:asialoerythropoietin; D004921:Erythropoietin; D006861:Hydrogen Peroxide; D010751:Phosphopyruvate Hydratase