The -509 C/T genotype of TGFbeta1 might contribute to the pathogenesis of benign airway stenosis.
Benign airway stenosis (BAS) is one of the most severe complications of endotracheal intubation. The aim of this pilot study was to compare the frequencies of four polymorphisms of the transforming growth factor (TGF) beta1 gene in patients with BAS due to endotracheal intubation (n = 36) and a control group of intensive care patients who had also undergone endotracheal intubation but did not present BAS (n = 30). One of the studied polymorphisms, the -509 C/T, demonstrated a differential genotype distribution between the affected and the control population: the ratio of heterozygous mutants was significantly (P = 0.0116) higher among the control patients. These data suggest a protective function of the frequent heterozygous C/T genotype against BAS; alternatively, the C/C genotype might be a susceptibility factor for BAS (OR 4.5; 95% CI 1.5123-13.3902). Our findings suggest that, besides other iatrogenic factors, a genetic predisposition might contribute to the pathogenesis of BAS.
Rovó
László
L
Department of Oto-Rhino-Laryngology and Head-Neck Surgery, University of Szeged, Szeged, Hungary. rovo@invitel.hu
Széll
Márta
M
Bella
Zsolt
Z
Korsós
Anita
A
Kemény
Lajos
L
Jóri
József
J
D000328:Adult; D000368:Aged; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D008875:Middle Aged; D010865:Pilot Projects; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D014135:Tracheal Stenosis / Q000209:etiology / Q000235:genetics*; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D014945:Wound Healing / Q000502:physiology
D053773:Transforming Growth Factor beta1