title: Towards genome-scale signalling network reconstructions.
abstract: Biological signalling networks allow living organisms to issue an integrated response to current conditions and make limited predictions about future environmental changes. Small-scale dynamic models of signalling cascades, including mitogen-activated protein kinase cascades, have been developed to generate hypotheses about signal transduction. Owing to technical limitations, these models and the hypotheses they generate have focused on a limited subset of signalling molecules. Now that we can simultaneously measure a substantial portion of the molecular components of a cell, we can begin to develop and test systems-level models of cellular signalling and regulatory processes, therefore gaining insights into the 'thought' processes of a cell.
authors.affiliation: Department of Bioengineering, University of California-San Diego, 9500 Gilman Drive, La Jolla, California 92093-0412, USA. hyduke@ucsd.edu
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Hyduke
authors.forename: Bernhard Ø
authors.initials: BØ
authors.lastname: Palsson
mesh_terms: D000818:Animals; D053263:Gene Regulatory Networks; D023281:Genomics; D006801:Humans; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D008957:Models, Genetic; D015398:Signal Transduction / Q000235:genetics*; D049490:Systems Biology