title: Effects of immunotoxic activity of the major essential oil of Angelica purpuraefolia Chung against Aedes aegypti L.
abstract: The rhizomes parts of Angelica purpuraefolia were extracted and the major essential oils composition and immunotoxic effects were studied. The analyses were conducted by gas chromatography and mass spectroscopy (GC-MS) revealed that the essential oils of A. purpuraefolia. The A. purpuraefolia essential oil (APEO) yield was 0.37%, and GC/MS analysis revealed that its major constituents were β-Phellandrene (32.11%), Nerolidol (10.11%), Pyrimidine derivative (27.33%), Heptadecane (4.33%), and Celorbicol (6.33%). The essential oil had a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with an LC(50) value of 31.21 ppm and an LC(90) value of 87.22 ppm. The results could be useful in search for newer, safer, and more effective natural immunotoxic agents against A. aegypti.
authors.affiliation: Division of Environmental and Resource, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan, South Korea.
authors.forename: Yool-Jin
authors.initials: YJ
authors.lastname: Park
authors.forename: Ill-Min
authors.initials: IM
authors.lastname: Chung
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Moon
mesh_terms: D000330:Aedes / Q000187:drug effects*; D000473:Alkanes / Q000032:analysis; D029969:Angelica / Q000737:chemistry*; D000818:Animals; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D039821:Monoterpenes / Q000032:analysis; D009822:Oils, Volatile / Q000032:analysis / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D011743:Pyrimidines / Q000032:analysis; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000032:analysis
chemical_list: D000473:Alkanes; D000081005:Cyclohexane Monoterpenes; D053138:Cyclohexenes; D039821:Monoterpenes; D009822:Oils, Volatile; D010936:Plant Extracts; D011743:Pyrimidines; D012717:Sesquiterpenes; C058582:beta-phellandrene; C016486:heptadecane; C037055:nerolidol