title: Risk factors for periventricular-intraventricular hemorrhage in premature infants.
abstract: Periventricular-intraventricular hemorrhage (PV-IVH) is a major cause of neurological disabilities in preterm newborns. This study aimed to determine the perinatal factors associated with PV-IVH. We conducted a retrospective case-control study from preterm infants born at < or =34 weeks of gestation and admitted to Neonatal Intensive Care Units of Seoul National University Children's Hospital and Seoul National University Bundang Hospital between June 2003 and December 2007. Neonates with no cranial sonographic data or infants transferred from other centers after three days of age were excluded. Of 1,044 eligible subjects, 59 infants with PV-IVH grade 2, 3, and 4 were allocated to the case group. The control group consisted of 118 infants without PV-IVH who were matched for gestational age and birth weight to each case of PV-IVH. At the multivariate logistic regression model, metabolic acidosis (odds ratio [OR]: 6.94; 95% confidence interval [CI]: 1.12-43.23) and use of inotropes (OR: 3.70; 95% CI: 1.16-11.84) were associated with an increased risk of PV-IVH. Maternal use of antenatal corticosteroids decreases the risk of PV-IVH (OR: 0.36; 95% CI: 0.14-0.92).
authors.affiliation: Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Ju Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Han Suk
authors.initials: HS
authors.lastname: Kim
authors.forename: Euiseok
authors.initials: E
authors.lastname: Jung
authors.forename: Eun Sun
authors.initials: ES
authors.lastname: Kim
authors.forename: Gyu Hong
authors.initials: GH
authors.lastname: Shim
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Lee
authors.forename: Jin A
authors.initials: JA
authors.lastname: Lee
authors.forename: Chang Won
authors.initials: CW
authors.lastname: Choi
authors.forename: Ee-Kyung
authors.initials: EK
authors.lastname: Kim
authors.forename: Beyong Il
authors.initials: BI
authors.lastname: Kim
authors.forename: Jung-Hwan
authors.initials: JH
authors.lastname: Choi
mesh_terms: D000138:Acidosis / Q000150:complications; D000328:Adult; D001724:Birth Weight; D002316:Cardiotonic Agents / Q000009:adverse effects; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000473:pathology; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000209:etiology* / Q000473:pathology; D008297:Male; D016017:Odds Ratio; D011247:Pregnancy; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D002316:Cardiotonic Agents