title: Endoscopic management of emphysema.
abstract: Lung volume reduction surgery has proven benefits in emphysema. However, high postoperative morbidity and stringent selection criteria for suitable candidates are limitations in clinical practice. Endoscopic approaches to lung volume reduction have used a range of different techniques such as endobronchial blockers, airway bypass, endobronchial valves, biologic sealants, and airway implants to address the limitations of surgery. The underlying physiologic mechanisms of endoscopic modalities vary, and homogeneous and heterogeneous emphysema are targeted. Currently available data on efficacy of bronchoscopic lung volume reduction are not consistently conclusive, and subjective benefit in dyspnea scores is a more frequent finding than improvements on spirometry or exercise tolerance. The safety data are more promising, with rare procedure-related mortality, fewer complications than lung volume reduction surgery, and short hospital length of stay. The field of bronchoscopic lung volume reduction continues to evolve as ongoing prospective randomized trials aim to clarify the efficacy data from earlier feasibility and safety studies.
authors.affiliation: Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA. aernst@bidmc.harvard.edu
authors.forename: Armin
authors.initials: A
authors.lastname: Ernst
authors.forename: Devanand
authors.initials: D
authors.lastname: Anantham
mesh_terms: D015444:Exercise / Q000502:physiology; D006801:Humans; D011013:Pneumonectomy / Q000379:methods* / Q000401:mortality; D019736:Prostheses and Implants; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology / Q000601:surgery; D011656:Pulmonary Emphysema / Q000503:physiopathology / Q000628:therapy*