Primary ALK-positive anaplastic large cell lymphoma of the breast: a case report and review of the literature.
BACKGROUND
Non-Hodgkin lymphomas of the breast are uncommon, which represent less than 1% of all breast malignancies and predominantly are of B-cell origin.


METHODS
In this report, a rare case of anaplastic lymphoma kinase (ALK)-positive anaplastic large T-cell lymphoma in the breast of a 16-year-old female without breast implant is described. The patient presented with a 3-month history of progressive right breast swelling and erythema. Clinically, inflammatory breast carcinoma was highly suspected. A tru-cut needle biopsy of the right breast demonstrated infiltration of tumoral cells around the breast lobules and soft tissue and also in angiolymphatic spaces. The immunohistochemical profile showed positivity for CD30 and ALK and confirmed the diagnosis of ALK-positive anaplastic large T-cell lymphoma of the breast.


CONCLUSIONS
Anaplastic large T-cell lymphoma of the breast is rare, and can clinically mimic inflammatory breast carcinoma in adolescence.
Daneshbod
Yahya
Y
Department of Hematopathology, Dr Daneshbod Pathology Laboratory, Shiraz University of Medical Sciences, Shiraz, Iran.
Oryan
Ahmad
A
Khojasteh
Habib N
HN
Rasekhi
Alireza
A
Ahmadi
Nasrollah
N
Mohammadianpanah
Mohammad
M
D000293:Adolescent; D000077548:Anaplastic Lymphoma Kinase; D001943:Breast Neoplasms / Q000175:diagnosis / Q000201:enzymology / Q000473:pathology*; D005260:Female; D006801:Humans; D017730:Ki-1 Antigen / Q000032:analysis; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis / Q000201:enzymology / Q000473:pathology*; D011505:Protein-Tyrosine Kinases / Q000032:analysis*; D020794:Receptor Protein-Tyrosine Kinases
D017730:Ki-1 Antigen; C000626173:ALK protein, human; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases