title: Spatio-temporal data fusion for 3D+T image reconstruction in cerebral angiography.
abstract: This paper provides a framework for generating high resolution time sequences of 3D images that show the dynamics of cerebral blood flow. These sequences have the potential to allow image feedback during medical procedures that facilitate the detection and observation of pathological abnormalities such as stenoses, aneurysms, and blood clots. The 3D time series is constructed by fusing a single static 3D model with two time sequences of 2D projections of the same imaged region. The fusion process utilizes a variational approach that constrains the volumes to have both smoothly varying regions separated by edges and sparse regions of nonzero support. The variational problem is solved using a modified version of the Gauss-Seidel algorithm that exploits the spatio-temporal structure of the angiography problem. The 3D time series results are visualized using time series of isosurfaces, synthetic X-rays from arbitrary perspectives or poses, and 3D surfaces that show arrival times of the contrasted blood front using color coding. The derived visualizations provide physicians with a previously unavailable wealth of information that can lead to safer procedures, including quicker localization of flow altering abnormalities such as blood clots, and lower procedural X-ray exposure. Quantitative SNR and other performance analysis of the algorithm on computational phantom data are also presented.
authors.affiliation: Draper Laboratory, Cambridge, MA 02139, USA. acopeland@alum.mit.edu
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Copeland
authors.forename: Rami S
authors.initials: RS
authors.lastname: Mangoubi
authors.forename: Mukund N
authors.initials: MN
authors.lastname: Desai
authors.forename: Sanjoy K
authors.initials: SK
authors.lastname: Mitter
authors.forename: Adel M
authors.initials: AM
authors.lastname: Malek
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000502:physiology*; D002533:Cerebral Angiography / Q000379:methods*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique