[Molecular basis of HIV-1 latency - part I: physiology of HIV-1 latency].
The introduction of the highly active antiretroviral therapy (HAART) in 1996 has greatly extended survival and raised hopes for the eradication of HIV-1. Unfortunately, the optimism declined by revealing the existence of latent HIV-1 reservoirs in cells targeted by the virus. The long-lived HIV-1 reservoirs constitute a major obstacle to the eradication of HIV-1. Understanding the molecular mechanisms of virus latency is essential for efficient therapeutic intervention against the virus.
Schwartz
Christian
C
Inserm Unité 575 Physiopathologie du système nerveux central, Institut de virologie, Strasbourg, France. schwartz.christian@iutlpa-strasbg.fr
Le Douce
Valentin
V
Cherrier
Thomas
T
Redel
Laetitia
L
Marban
Céline
C
Aunis
Dominique
D
Rohr
Olivier
O
D004279:DNA, Viral / Q000235:genetics; D044127:Epigenesis, Genetic; D015967:Gene Expression Regulation, Viral; D015658:HIV Infections / Q000821:virology; D015497:HIV-1 / Q000235:genetics / Q000502:physiology*; D054884:Host-Pathogen Interactions; D006801:Humans; D017628:Microglia / Q000821:virology; D011533:Proviruses / Q000235:genetics / Q000502:physiology; D012367:RNA, Viral / Q000235:genetics; D014158:Transcription, Genetic; D016662:Virus Integration; D017735:Virus Latency / Q000235:genetics / Q000502:physiology*
D004279:DNA, Viral; D012367:RNA, Viral