title: Mass barium carbonate poisoning with fatal outcome, lessons learned: a case series.
abstract: BACKGROUND
  Barium, a heavy divalent alkaline metal, has long been known to cause human toxicity. The common mode is accidental ingestion and the common compound is Barium carbonate. Here we report an incident of food poisoning in 27 law enforcement personnel with rapidly developing sequelae and a high mortality due to ingestion of Barium carbonate contaminated flour.
  
  
  METHODS
  One midnight, 27 adult males were rushed to emergency department of Chittagong Medical College Hospital with abdominal pain, vomiting, loose motion, cramps and generalized paraesthesia. The ailment started 1-2 hours after Iftar (evening meal to break day long fast during Ramadan) which included fried vegetables coated with a flour paste. On admission, twenty of them were restless, agitated. 22 reported weakness of limbs and were unable to walk. 10 had hypotension. 22 had rapid and shallow respiration. 5 had carpopedal spasm. Different grades of limb weakness were noted with loss of tendon jerks. Ten (N12) patients had hypokalaemia, three had hypoglycaemia, 4 patients had high creatine kinase. ECG showed flat ST with U waves in 4 patients. Potassium containing intravenous fluid and Oxygen was administered. Due to limited availability of mechanical ventilators patients were put on artificial respiration using Ambu bag; manually maintained by doctors, paramedics and attendants. Four patients were transferred to another hospital for mechanical ventilation. A total of 12 patients died over next 16 hours, 4 within 3 hrs. Other patients gradually improved. Chemical analysis of the vomitus, blood and flour used for preparation of meal revealed the presence of Barium. It was assumed that the flour was contaminated with the similar looking Barium carbonate powder which was kept in the kitchen as a rodenticide.
  
  
  CONCLUSIONS
  This event exemplifies the weakness of usual health care facility in resource poor settings to cope with this kind of massive poisoning event. The multiple reported incidences of accidental barium poisoning due to unintentional mixing with food signifies the fact that the use and availability of barium carbonate should be restricted. We hope to draw attention to this relatively uncommon poisoning and to the need for development of poison information centre in resource poor countries.
authors.affiliation: Department of Medicine, Chittagong Medical College, (4000), Chittagong, Bangladesh. anrdghs@yahoo.com
authors.forename: Aniruddha
authors.initials: A
authors.lastname: Ghose
authors.forename: Absullah Abu
authors.initials: AA
authors.lastname: Sayeed
authors.forename: Amir
authors.initials: A
authors.lastname: Hossain
authors.forename: Ridwanur
authors.initials: R
authors.lastname: Rahman
authors.forename: Abul
authors.initials: A
authors.lastname: Faiz
authors.forename: Gofranul
authors.initials: G
authors.lastname: Haque