Antimicrobial activity of the extracts of Craniotome furcata (Lamiaceae).
BACKGROUND
Craniotome furcata (Link.) O. Kuntze (Lamiaceae) is used in the traditional medicine for the treatment of cuts and wounds indicating antimicrobial activity.


OBJECTIVE
To validate the traditional medicinal claim, in vitro antimicrobial activity of the extracts was screened against eleven human pathogenic bacteria and fungi.


METHODS
The ethyl acetate (CE) and n-butanol (CB) extracts of the aerial parts of Craniotome furcata were tested against four Gram-positive bacteria, four Gram-negative bacteria and three fungi species. Antimicrobial activity was determined by the tube-dilution method.


RESULTS
The CE and CB extracts showed antimicrobial activity against all of the tested microorganisms, with minimum inhibitory concentration (MIC) values in the range of 0.41-4.58mg/ml.


CONCLUSIONS
The tested microbes Micrococcus flavus and Escherichia coli were highly susceptible to extract CE and antimicrobial activity of CB is comparable to that of extract CE against Escherichia coli and Staphylococcus faecalis while it is better than that of extract CE, against Klebsiella pneumoniae. Both the extracts were found less susceptible against tested fungi.
Joshi
R K
RK
Regional Medical Research Center, Indian Council of Medical Research, Belgaum, Karnataka 590010, India. joshirk_natprod@yahoo.com
Mujawar
M H K
MH
Kholkute
S D
SD
D020001:1-Butanol; D000890:Anti-Infective Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004304:Dosage Forms; D004926:Escherichia coli / Q000187:drug effects; D020834:Ethnopharmacology; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D019686:Lamiaceae; D008519:Medicine, Traditional; D008826:Microbial Sensitivity Tests
D000890:Anti-Infective Agents; D004304:Dosage Forms; D020001:1-Butanol