[Effects of 3-hydroxypyridine and succinic acid derivatives on the dynamics of dorsalgia and affective disorders after surgical treatment of disc herniation].
A prospective, placebo-controlled randomized study of the effects of 3-hydropxypyridine and succinic acid derivatives (emoxipine, reamberin and mexi the early dynamics of dorsalgia and the corresponding affective disorders has been performed in 136 patients after surgical treatment of lumbal disc hen It is established that a two-week administration of all preparations reduced the manifestations of depression during 3.5 months after spinal surgery. The course of emoxipine (150 mg, i.v., daily) produced an antidepressant effect without any changes in the dynamics of dorsalgia, psychological dysada (PD), and quality of life (QL). The 14-day administration of reamberin (400 ml, i.v., daily) significantly reduced in the manifestations of depression and pathic pain, without any effect upon nociceptive pain, PD, and QL dynamics. The two-week course of mexidol (300 mg, i.v., daily) led to the most pron antidepressant effect, which was accompanied by the attenuation of both nociceptive and neuropathic pain, a decrease in PD, and appreciable increase in ter the surgical treatment.
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D000328:Adult; D005260:Female; D006801:Humans; D007405:Intervertebral Disc Displacement / Q000601:surgery*; D017116:Low Back Pain / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D008536:Meglumine / Q000627:therapeutic use*; D019964:Mood Disorders / Q000188:drug therapy* / Q000523:psychology; D010149:Postoperative Pain / Q000188:drug therapy / Q000523:psychology; D010847:Picolines / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy* / Q000523:psychology; D011788:Quality of Life; D016037:Single-Blind Method; D013386:Succinates / Q000627:therapeutic use*
D010847:Picolines; D013386:Succinates; C070020:emoxypine succinate; D008536:Meglumine; C009820:6-methyl-2-ethyl-3-hydroxypyridine