Antihepatotoxic activity of debelalactone, a new oxirano-furanocoumarin from Phyllanthus debilis.
The whole plant of Phyllanthus debilis (Euphorbiacae) afforded a new oxirano-furanocoumarin, characterized as 5-hydroxy-7-methoxy-furanocoumarin-9(14)-cyclohex-12(13)-oxirano-11-one (1), named as debelalactone. Debelalactone exhibited a significant antihepatotoxic activity by reducing the elevated levels of serum enzymes such as serum glutamate oxaloacetate transaminase (SGOT) by 59.14%, serum glutamate pyruvate oxaloacetate transaminase (SGPT) by 61.84%, and alkaline phosphatase (ALP) by 85.93%; while the total protein (TP) levels were increased by 110.35%, when compared with standard drug silymarin that have decreased SGOT by 77.03%, SGPT by 69.67%, ALP by 93.18%, and increased TP levels by 100.48%, respectively, against CCl(4)-induced toxicity in Wistar rats. These biochemical observations were also supplemented by histopathological examinations of the liver sections.
Ahmed
Bahar
B
Antihepatotoxic Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi, India.
Khan
Shamshir
S
Verma
Amita
A
Habibullah
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood*; D002251:Carbon Tetrachloride / Q000494:pharmacology; D011564:Furocoumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007194:India; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008297:Male; D015394:Molecular Structure; D029803:Phyllanthus / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D011564:Furocoumarins; C547614:debelalactone; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000469:Alkaline Phosphatase