title: Plasma asymmetric dimethylarginine concentrations in sickle cell disease are related to the hemolytic phenotype.
abstract: Asymmetric dimethylarginine (ADMA) is associated with pulmonary hypertension (PHT) in sickle cell disease (SCD). We studied the relationship of ADMA to other SCD-related complications. Plasma ADMA and associated parameters were determined in 52 HbSS/HbSbeta(0)-thalassemia and 24 HbSC/HbSbeta(+)-thalassemia patients. As expected ADMA levels were higher in HbSS/HbSbeta(0)-thalassemia patients with PHT (p=0.018), but also in those with other hemolysis-associated complications such as leg ulcers (p=0.012), cholelithiasis (p=0.008) and priapism (p=0.02) compared with counterparts without these complications. ADMA levels did not differ between patients with and without other disease related complications such as retinopathy and avascular osteonecrosis. Higher ADMA concentrations therefore seem to be associated to the hemolytic phenotype of SCD.
authors.affiliation: Immunology Laboratory Department, Red Cross Blood Bank Foundation Curaçao, Curaçao, Netherlands Antilles.
authors.forename: P P
authors.initials: PP
authors.lastname: Landburg
authors.forename: T
authors.initials: T
authors.lastname: Teerlink
authors.forename: B J
authors.initials: BJ
authors.lastname: Biemond
authors.forename: D P M
authors.initials: DP
authors.lastname: Brandjes
authors.forename: F A J
authors.initials: FA
authors.lastname: Muskiet
authors.forename: A J
authors.initials: AJ
authors.lastname: Duits
authors.forename: J B
authors.initials: JB
authors.lastname: Schnog
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000097:blood / Q000209:etiology; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications / Q000235:genetics; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D002769:Cholelithiasis / Q000097:blood / Q000209:etiology; D005260:Female; D006461:Hemolysis; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood / Q000209:etiology; D007871:Leg Ulcer / Q000097:blood / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood / Q000172:deficiency; D010020:Osteonecrosis / Q000097:blood / Q000209:etiology; D010641:Phenotype; D011317:Priapism / Q000097:blood / Q000209:etiology; D012164:Retinal Diseases / Q000097:blood / Q000209:etiology; D012805:Sickle Cell Trait / Q000097:blood / Q000150:complications / Q000235:genetics; D055815:Young Adult; D017086:beta-Thalassemia / Q000097:blood / Q000145:classification / Q000235:genetics
chemical_list: D009569:Nitric Oxide; C024917:symmetric dimethylarginine; C018524:N,N-dimethylarginine; D001120:Arginine