Synthesis of AZT-based cationic lipids and in vitro evaluation of siRNA delivery.
New types of cationic lipids based on AZT were evaluated for their biological effects in terms of their cytotoxicity and their cellular delivery of siRNA.
Park
Sun Min
SM
Department of Chemistry, BK School of Molecular Science, Pohang University of Science and Technology, Pohang 790-784, South Korea.
Woo
Jungeun
J
Jeon
Eunmi
E
Kim
Byeang Hyean
BH
D002412:Cations / Q000737:chemistry*; D004337:Drug Carriers; D004797:Enzyme-Linked Immunosorbent Assay; D006367:HeLa Cells; D006801:Humans; D052578:Ionic Liquids / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics; D015215:Zidovudine / Q000737:chemistry*
D002412:Cations; D004337:Drug Carriers; D052578:Ionic Liquids; D034741:RNA, Small Interfering; D042461:Vascular Endothelial Growth Factor A; D015215:Zidovudine