title: Irreversible, direct bonding of nanoporous polymer membranes to PDMS or glass microdevices.
abstract: A method for integrating porous polymer membranes such as polycarbonate, polyethersulfone and polyethylene terephthalate to microfluidic devices is described. The use of 3-aminopropyltriethoxysilane as a chemical crosslinking agent was extended to integrate membranes with PDMS and glass microfluidic channels. A strong, irreversible bond between the membranes and microfluidic structure was achieved. The bonding strength in the APTES treated devices was significantly greater than in devices fabricated using either a PDMS "glue" or two-part epoxy bonding method. Evaluation of a filtering microdevice and the pore structure via SEM indicates the APTES conjugation does not significantly alter the membrane transport function and pore morphology.
authors.affiliation: Department of Biomedical Engineering, Rutgers University, 599 Taylor Road, Piscataway, NJ 08854, USA.
authors.forename: Kiana
authors.initials: K
authors.lastname: Aran
authors.forename: Lawrence A
authors.initials: LA
authors.lastname: Sasso
authors.forename: Neal
authors.initials: N
authors.lastname: Kamdar
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Zahn
mesh_terms: D000268:Adhesiveness; D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D005898:Glass / Q000737:chemistry*; D008422:Materials Testing; D008567:Membranes, Artificial; D055617:Micro-Electrical-Mechanical Systems / Q000295:instrumentation*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure*; D011108:Polymers / Q000737:chemistry; D016062:Porosity; D013718:Tensile Strength
chemical_list: D004129:Dimethylpolysiloxanes; D008567:Membranes, Artificial; D011108:Polymers; C013830:baysilon