title: Efficacy of a 5-day extended therapy program during lactation with cephapirin sodium in dairy cows chronically infected with Staphylococcus aureus.
abstract: This study determined the efficacy of a 5-day extended therapy with cephapirin sodium in dairy cows chronically infected with Staphylococcus aureus. Chronically infected cows selected from 14 dairy herds in the St-Hyacinthe region, Québec were randomly allocated to a group of 31 cows treated for 5 consecutive days with 200 mg of cephapirin per quarter BID or a group of 30 untreated control cows. Bacteriological cure was determined by 3 negative bacterial cultures at 10, 24, and 31 days after treatment. The cow cure rates were 25.8% (8/31) in the treated cows and 3.3% (1/30) in the control group (P = 0.013). The quarter cure rates at first sampling post-treatment were 77.6% (38/49) and 18% (9/50) in the treated and the control groups, respectively (P < 0.0001). A 5-day extended therapy with cephapirin is effective in treating cows chronically infected with S. aureus.
authors.affiliation: Département de sciences cliniques, Faculté de médecine vétérinaire, Université de Montréal, 3200, rue Sicotte, CP 5000, St-Hyacinthe, Québec, Canada. jean-philippe.roy@umontreal.ca
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Roy
authors.forename: Luc
authors.initials: L
authors.lastname: DesCôteaux
authors.forename: Denis
authors.initials: D
authors.lastname: DuTremblay
authors.forename: Francis
authors.initials: F
authors.lastname: Beaudry
authors.forename: Johanne
authors.initials: J
authors.lastname: Elsener
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002417:Cattle; D002514:Cephapirin / Q000627:therapeutic use*; D002908:Chronic Disease; D003612:Dairying; D005260:Female; D008414:Mastitis, Bovine / Q000188:drug therapy*; D011792:Quebec; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000662:veterinary*; D013211:Staphylococcus aureus / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D002514:Cephapirin