Case of localized scleroderma successfully treated with bath psoralen and ultraviolet A therapy.
The patient was a 12-year-old girl with linear scleroderma distributed on the right abdomen, dorsal aspect of the right thigh, lower leg and foot. The initial regimen of oral prednisolone and methotrexate, or i.v. methylprednisolone failed in the treatment of the scleroderma. Then bath psoralen and ultraviolet A therapy (bath-PUVA) therapy of 0.2 J-4.0 J/cm(2) daily to total doses 62.8 J/cm(2) combined with oral prednisolone was started. After bath-PUVA therapy, regression of the skin sclerosis was observed, the possible mobile range of the right ankle was increased and histological examination confirmed improvement of the sclerosis. The successful results of bath-PUVA therapy in this case suggest its utility for localized scleroderma.
Uchiyama
Masaki
M
Department of Dermatology, Tokyo Medical University, Tokyo, Japan.
Okubo
Yukari
Y
Kawashima
Hisashi
H
Yamamoto
Kengo
K
Mitsuhashi
Yoshihiko
Y
Tsuboi
Ryoji
R
D000279:Administration, Cutaneous; D000843:Ankle Joint / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D001494:Baths; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D005355:Fibrosis; D005363:Ficusin / Q000008:administration & dosage*; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D011701:PUVA Therapy; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D012594:Scleroderma, Localized / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome
D011239:Prednisolone; D005363:Ficusin; D008775:Methylprednisolone; D008727:Methotrexate