Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease.
A bis (thiosemicarbazonato) complex radiolabeled with positron emitting Cu-64 can be used for a new and alternative method for the non-invasive diagnosis of Alzheimer's disease using positron emission tomography (PET). Most imaging agents being investigated for the diagnosis of Alzheimer's disease target amyloid-beta plaque burden but our new approach highlights altered copper homeostasis. This approach has the potential to offer complementary information to other diagnostic procedures that elucidate plaque burden.
Fodero-Tavoletti
Michelle T
MT
Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia.
Villemagne
Victor L
VL
Paterson
Brett M
BM
White
Anthony R
AR
Li
Qiao-Xin
QX
Camakaris
James
J
O'Keefe
Graeme
G
Cappai
Roberto
R
Barnham
Kevin J
KJ
Donnelly
Paul S
PS
D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging; D001931:Brain Mapping; D003301:Copper Radioisotopes / Q000737:chemistry; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D049268:Positron-Emission Tomography / Q000379:methods*; D053764:Presenilin-1 / Q000235:genetics; D019275:Radiopharmaceuticals / Q000737:chemistry; D014018:Tissue Distribution; D051844:alpha-Synuclein / Q000378:metabolism
D016564:Amyloid beta-Protein Precursor; D003301:Copper Radioisotopes; C508853:PSEN1 protein, human; D053764:Presenilin-1; D019275:Radiopharmaceuticals; D051844:alpha-Synuclein