Effect of concord grape juice on chemotherapy-induced nausea and vomiting: results of a pilot study.
OBJECTIVE
To determine the feasibility of administering a flavonoid-rich adjunctive treatment (Concord grape juice) for the management of chemotherapy-induced nausea and vomiting (CINV); to evaluate the usefulness of existing measures for assessing CINV frequency and severity, quality of life, control over life events, and psychological state; to identify any actual or potential adverse events associated with frequent grape juice intake; and to provide preliminary data concerning the effect of Concord grape juice on CINV, quality of life, perceived control over life events, and psychological state.


METHODS
Double-blind, randomized clinical trial.


METHODS
A cancer center in an academic health science center in the northeastern United States.


METHODS
77 adult patients with cancer receiving moderately or highly emetogenic chemotherapy agents.


METHODS
Participants drank 4 oz. of grape juice or placebo prior to meals for one week following each of four chemotherapy treatment cycles. They recorded frequency, duration, and distress of nausea, vomiting, and retching daily, beginning the evening of chemotherapy administration and continuing for seven days. Data were analyzed with generalized estimating equations methodology to model differences between groups over time.


METHODS
Nausea and vomiting frequency, duration, and distress; quality of life; control over decision making; and psychological state.


RESULTS
Nausea and vomiting frequency, duration, and distress were lower for experimental group members, although a high attrition rate (50%) resulted in insufficient power to detect statistically significant differences over time. Greater levels of anxiety, depression, and hostility at baseline were related to nausea and vomiting, quality of life, and perceived control over decision making.


CONCLUSIONS
The effect of grape juice flavonoids on CINV should be investigated further with a larger sample to determine whether preliminary findings are supported. Alterations to the study protocol will be necessary to decrease attrition.


CONCLUSIONS
Flavonoid-rich fruits and vegetables may provide additional protection against CINV. If the compounds work, they would offer a low-cost, readily available adjunctive treatment for the management of CINV.
Ingersoll
Gail L
GL
University of Rochester Medical Center, New York, USA. gail_ingersoll@urmc.rochester.edu
Wasilewski
Amy
A
Haller
Michele
M
Pandya
Kishan
K
Bennett
John
J
He
Hua
H
Hoffmire
Claire
C
Berry
Cynthia
C
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001628:Beverages; D004435:Eating; D005260:Female; D005419:Flavonoids / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000178:diet therapy*; D009369:Neoplasms / Q000188:drug therapy* / Q000451:nursing / Q000523:psychology; D009859:Oncology Nursing / Q000379:methods; D010865:Pilot Projects; D011594:Psychometrics; D011788:Quality of Life; D016896:Treatment Outcome; D027843:Vitis; D014839:Vomiting / Q000139:chemically induced / Q000178:diet therapy*
D000970:Antineoplastic Agents; D005419:Flavonoids