New aspects in vascular gene therapy.
Advances in clinical gene therapy have been modest although significant progress has been made during the past few years. New viruses have been introduced and new results have been collected from preclinical and clinical studies. This review will focus on cardiovascular and especially proangiogenic gene therapy. Recent results from preclinical developments and clinical trials will be discussed.
Karvinen
Henna
H
Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Finland.
Ylä-Herttuala
Seppo
S
D000818:Animals; D002318:Cardiovascular Diseases / Q000628:therapy*; D002986:Clinical Trials as Topic; D018014:Gene Transfer Techniques / Q000009:adverse effects; D015316:Genetic Therapy / Q000009:adverse effects / Q000379:methods*; D005822:Genetic Vectors / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D018919:Neovascularization, Physiologic / Q000235:genetics*; D014780:Viruses