Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients.
OBJECTIVE
To investigate the association of nephrolithiasis and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9.


METHODS
A total of 145 participants were recruited in the period April-October 2008 from the Department of Mineral Research of the Medical School Osijek, Osijek, Croatia; 58 (40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic. Four single nucleotide polymorphisms (SNP) from the SLC2A9 gene were genotyped in both groups (rs733175, rs6449213, rs1014290, and rs737267).


RESULTS
There was a weak but significant association of all 4 SNPs and nephrolithiasis (P=0.029 for rs733175; P=0.006 for rs6449213; P=0.020 for rs1014290, and P=0.011 for rs737267). Logistic regression in an age- and sex-adjusted model suggested that genotype C/T for rs6449213 had odds ratio for nephrolithiasis of 2.89 (95% confidence interval 1.13-7.40). This SNP explained a total of 4.4% of nephrolithiasis variance.


CONCLUSIONS
Development of nephrolithiasis may be associated with SLC2A9 gene. Further studies are needed to clarify the role of SLC2A9 gene as a link between uric acid and nephrolithiasis.
Polasek
Ozren
O
Department of Medical Statistics, Epidemiology, and Medical Informatics, Andrija Stampar School of Public Health, Medical School, University of Zagreb, Rockefellerova 4, 10000 Zagreb, Croatia. opolasek@snz.hr
Gunjaca
Grgo
G
Kolcić
Ivana
I
Zgaga
Lina
L
Dzijan
Snjezana
S
Smolić
Robert
R
Smolić
Martina
M
Milas-Ahić
Jasminka
J
Serić
Vatroslav
V
Galić
Josip
J
Tucak-Zorić
Sandra
S
Tucak
Antun
A
Rudan
Igor
I
Lauc
Gordan
G
D000328:Adult; D000368:Aged; D017523:Croatia; D005260:Female; D005820:Genetic Testing; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D053040:Nephrolithiasis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
D051246:Glucose Transport Proteins, Facilitative; C411811:SLC2A9 protein, human