title: 3-Substituted pyrazinone nucleosides--a new family of D4T analogues.
abstract: The synthesis of a new family of D4T analogues is described to study the influence of pyrazinone base on antiretroviral power. Substitution of 3H by methyl or n-decyl increases the lipophilic character and may facilitate diffusion across cell membranes. The compounds were characterized by (1)H NMR and infrared spectroscopy. Antiviral (HIV-1) properties of these compounds were examined.
authors.affiliation: Laboratoire de Chimie des Substances Naturelles, Faculté des Sciences et Techniques, Universite de Limoges, Limoges, France.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Batoux
authors.forename: Robert
authors.initials: R
authors.lastname: Granet
authors.forename: Rachida
authors.initials: R
authors.lastname: Zerrouki
authors.forename: Pierre
authors.initials: P
authors.lastname: Krausz
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D011719:Pyrazines / Q000737:chemistry*; D018119:Stavudine / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D009705:Nucleosides; D011719:Pyrazines; D018119:Stavudine