A proposed structure of modified nucleosides expected to have high antiviral activity and low toxicity.
This article describes modified nucleosides with deactivated 3'-OH and modified at two or more positions. These are expected to have high antiviral activity as well as have low toxicity.
Ohrui
Hiroshi
H
Yokohama College of Pharmacy, Totsuka, Yokohama, Japan. h.ohrui@hamayaku.ac.jp
D019380:Anti-HIV Agents / Q000737:chemistry* / Q000627:therapeutic use; D000998:Antiviral Agents / Q000737:chemistry / Q000627:therapeutic use*; D015195:Drug Design; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D056004:Molecular Dynamics Simulation; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry* / Q000627:therapeutic use; D014372:Tubercidin / Q000031:analogs & derivatives* / Q000737:chemistry
C549391:7-deaza-2'-C-methyl-7-fluoroadenosine; D019380:Anti-HIV Agents; D000998:Antiviral Agents; D009705:Nucleosides; D014372:Tubercidin