title: Psychological effects of false-positive results in cystic fibrosis newborn screening: a two-year follow-up.
abstract: OBJECTIVE
  To evaluate parental stress after a false-positive result at the time of the cystic fibrosis (CF) newborn screening (NBS), attributable to heterozygotism or persistent hypertrypsinemia.
  
  
  METHODS
  A prospective study was conducted in 86 French families at 3, 12, and 24 months after NBS. A psychologist conducted interviews with a questionnaire, the Perceived Stress Scale, and the Vulnerable Child Scale.
  
  
  RESULTS
  Overall, 96.5% of parents said they had been anxious at the time of the sweat test. However, 86% felt entirely reassured 3 months after the test. The mean Perceived Stress Scale score did not differ from that observed in the French population. Mean Vulnerable Child Scale scores were high, associated with a low Parental Perception of Child Vulnerability. These results did not differ significantly at 1 and 2 years. In total, 86% to 100% of families no longer worried about CF. All parents stated that they would have the test performed again for another child.
  
  
  CONCLUSIONS
  CF NBS can lead to false-positive results, causing parental anxiety, which quickly decreases after a sweat test performed soon after the phone call.
authors.affiliation: CF Center University Hospital, Rennes, France.
authors.forename: Julie
authors.initials: J
authors.lastname: Beucher
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Leray
authors.forename: Eric
authors.initials: E
authors.lastname: Deneuville
authors.forename: Monique
authors.initials: M
authors.lastname: Roblin
authors.forename: Isabelle
authors.initials: I
authors.lastname: Pin
authors.forename: François
authors.initials: F
authors.lastname: Bremont
authors.forename: Dominique
authors.initials: D
authors.lastname: Turck
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Giniès
authors.forename: Pascal
authors.initials: P
authors.lastname: Foucaud
authors.forename: Gilles
authors.initials: G
authors.lastname: Rault
authors.forename: Jocelyne
authors.initials: J
authors.lastname: Derelle
authors.forename: Valérie
authors.initials: V
authors.lastname: David
authors.forename: Hubert
authors.initials: H
authors.lastname: Journel
authors.forename: Sophie
authors.initials: S
authors.lastname: Marchand
authors.forename: David
authors.initials: D
authors.lastname: Veillard
authors.forename: Michel
authors.initials: M
authors.lastname: Roussey
mesh_terms: D001007:Anxiety / Q000209:etiology; D003550:Cystic Fibrosis / Q000175:diagnosis* / Q000523:psychology; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics; D005189:False Positive Reactions; D005260:Female; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009154:Mutation; D015997:Neonatal Screening / Q000523:psychology*; D010290:Parents / Q000523:psychology*; D013542:Sweat / Q000737:chemistry; D014357:Trypsin / Q000097:blood
chemical_list: D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D014357:Trypsin