title: IMRT-based optimization approaches for volumetric modulated single arc radiotherapy planning.
abstract: This paper reports on an evaluation of 5 RapidArc optimization approaches vs IMRT. This study includes 11 patients with adenocarcinoma of the prostate. Rectal Normal Tissue Complication Probability is used as a constraint in a dose escalation. RapidArc rectal NTCP's are lower than those of IMRT (p = 0.007). This allows a mean dose escalation of 2.1 Gy([0.7 Gy,3.5 Gy]).
authors.affiliation: Department of Radiotherapy, University Hospital Leuven, Leuven, Belgium. wouter.crijns@uz.kuleuven.be
authors.forename: Wouter
authors.initials: W
authors.lastname: Crijns
authors.forename: Tom
authors.initials: T
authors.lastname: Budiharto
authors.forename: Gilles
authors.initials: G
authors.lastname: Defraene
authors.forename: Jan
authors.initials: J
authors.lastname: Verstraete
authors.forename: Tom
authors.initials: T
authors.lastname: Depuydt
authors.forename: Karin
authors.initials: K
authors.lastname: Haustermans
authors.forename: Frank
authors.initials: F
authors.lastname: Van den Heuvel
mesh_terms: D000230:Adenocarcinoma / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011829:Radiation Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000295:instrumentation* / Q000379:methods*; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*