title: Thalamic activation and cortical deactivation during typical absence status monitored using [18F]FDG-PET: a case report.
abstract: We describe the ictal [(18)F]FDG-PET study of a case of absence status showing bilateral thalamic hypermetabolism and frontal cortex hypometabolism. This is the first ictal assessment of absence status by [(18)F]FDG-PET reporting this particular cortical and subcortical involvement. Our findings support the theory of corticothalamic circuitry involvement in the pathophysiology of absence seizures and stress the similarities of the clinical and metabolic pattern observed during absences with the pattern of task-induced interruption of the default state of brain function.
authors.affiliation: Epilepsy Center, Department of Neurological Sciences, Federico II University, Naples, Italy. ledabilo@fastwebnet.it
authors.forename: Leonilda
authors.initials: L
authors.lastname: Bilo
authors.forename: Roberta
authors.initials: R
authors.lastname: Meo
authors.forename: Maria Fulvia
authors.initials: MF
authors.lastname: de Leva
authors.forename: Caterina
authors.initials: C
authors.lastname: Vicidomini
authors.forename: Marco
authors.initials: M
authors.lastname: Salvatore
authors.forename: Sabina
authors.initials: S
authors.lastname: Pappatà
mesh_terms: D002540:Cerebral Cortex; D004832:Epilepsy, Absence / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D013788:Thalamus
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18