Multicompartmental micro- and nanocapsules: hierarchy and applications in biosciences.
Multicompartmentalized micro- and nanocapsules allow simultaneous delivery of several vectors or biomolecules; they are the next generation of carriers with increased complexity. Here we overview multicompartment micro- and nanocapsules and present a road-map for future developments in the field. Four basic building block structures are demonstrated, three isotropic: concentric, pericentric, and innercentric, and one anisotropic: acentric. As an elaborate implementation of multicompartmentalization, an enzyme-catalyzed reaction inside the same capsule carrying both an enzyme and a substrate is shown. Applications of multicompartmentalized microcapsules for simultaneous multiple drug delivery in bio-medicine are discussed.
Delcea
Mihaela
M
Max-Planck Institute of Colloids and Interfaces, Research Park Golm, Potsdam 14424, Germany. mihaela.delcea@mpikg.mpg.de
Yashchenok
Alexey
A
Videnova
Kristina
K
Kreft
Oliver
O
Möhwald
Helmuth
H
Skirtach
Andre G
AG
D002119:Calcium Carbonate / Q000737:chemistry; D002214:Capsules / Q000138:chemical synthesis / Q000737:chemistry*; D016503:Drug Delivery Systems; D006801:Humans; D053769:Nanocapsules / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D013678:Technology, Pharmaceutical
D002214:Capsules; D053769:Nanocapsules; D002119:Calcium Carbonate