HLA-DR association in papillary thyroid carcinoma.
OBJECTIVE
Papillary thyroid carcinoma (PTC) is the most frequent types of thyroid malignancies. Several genes may be involved in susceptibility of thyroid cancer including Human Leukocyte Antigens (HLA). The association of thyroid carcinoma with HLA alleles has been previously studied in other populations and certain HLA alleles were shown to be either predisposing or protective. The aim of this study was to determine the association between HLA-DR and papillary thyroid carcinoma in an Iranian population.


METHODS
HLA-DR antigen frequencies were determined in patients with papillary thyroid carcinoma (N=70) and non-related healthy controls (N=180) using PCR -SSP.


RESULTS
We found that HLA-DRB1*04 frequency was significantly higher in our patients compared to the controls [P=0.02, OR; 1.9, 95% CI (1.04-3.57)].


CONCLUSIONS
Our results revealed HLA-DRB1*04 as predisposing factor in papillary thyroid carcinoma in Iranian population. This confirms the previous findings for associations between HLA-DRB1 and differentiated carcinomas in other populations.
Amoli
Mahsa M
MM
Endocrinology and metabolism research centre, Tehran university of medical sciences, Tehran, Iran. mahsa_amoli@hotmail.com
Yazdani
Nasrin
N
Amiri
Parvin
P
Sayahzadeh
Forogh
F
Haghpanah
Vahid
V
Tavangar
Seyed Mohammad
SM
Amirzargar
Ali
A
Ghaffari
Hamidollah
H
Nikbin
Behrooz
B
Larijani
Bagher
B
Mostaan
Leila V
LV
Bazzaz
Javad Tavakkoly
JT
D000328:Adult; D002291:Carcinoma, Papillary / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000235:genetics*
D005819:Genetic Markers; D015236:HLA-C Antigens; D006684:HLA-DR Antigens