Influence of cellular and plasma procoagulant activity on the fibrin network.
At the nexus of cellular and plasma procoagulant activities lies fibrin, which is necessary to provide a clot's structural support. Abnormalities in fibrin network formation or function can result in either bleeding or thrombotic complications. Understanding relationships between procoagulant activity and normal fibrin formation, as well as pathophysiologic mechanisms leading to abnormal fibrin deposition, is essential for the continued development of hemostatic and antithrombotic therapies.
Wolberg
Alisa S
AS
Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, NC 27599-7525, USA. alisa_wolberg@med.unc.edu
Aleman
Maria M
MM
D000818:Animals; D001777:Blood Coagulation / Q000502:physiology; D003029:Coagulants / Q000737:chemistry / Q000378:metabolism*; D005337:Fibrin / Q000378:metabolism*; D005340:Fibrinogen / Q000737:chemistry; D006487:Hemostasis; D006801:Humans; D008954:Models, Biological; D010949:Plasma / Q000378:metabolism*; D013917:Thrombin / Q000378:metabolism*; D013925:Thromboplastin / Q000378:metabolism*; D013927:Thrombosis / Q000378:metabolism*
D003029:Coagulants; D005337:Fibrin; D005340:Fibrinogen; D013925:Thromboplastin; D013917:Thrombin