title: Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry.
abstract: High resolution localized surface plasmon resonance (HR-LSPR) sensors were combined with matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) for the first time. LSPR sensors provide real-time label-free detection of molecular adsorption. Subsequent MALDI-MS analysis enables identification of the adsorbed molecules. This synergistic LSPR-MS approach was applied to the detection and identification of amyloid beta oligomers which play an important role in the molecular pathogenesis of Alzheimer's Disease.
authors.affiliation: Department of Chemistry, Northwestern University, 214x5 Sheridan Road, Evanston, IL 60208, USA.. ; Tel: 747-491-3516;
authors.forename: Jeffrey N
authors.initials: JN
authors.lastname: Anker
authors.forename: W Paige
authors.initials: WP
authors.lastname: Hall
authors.forename: Mary P
authors.initials: MP
authors.lastname: Lambert
authors.forename: Pauline T
authors.initials: PT
authors.lastname: Velasco
authors.forename: Milan
authors.initials: M
authors.lastname: Mrksich
authors.forename: William L
authors.initials: WL
authors.lastname: Klein
authors.forename: Richard P
authors.initials: RP
authors.lastname: Van Duyne