title: Interaction and dynamics of the Plasmodium falciparum MTIP-MyoA complex, a key component of the invasion motor in the malaria parasite.
abstract: The myosin tail domain interacting protein-myosin A (MTIP-MyoA) protein complex is an essential element of the motor driving invasion of red blood cells by the Plasmodium species that cause malaria. Here we report the key determinants of binding at the MTIP/MyoA interface, and the first structural study on the complex in solution using protein NMR.
authors.affiliation: Department of Chemistry, Imperial College London, Exhibition Rd., London, UK SW7 2AZ
authors.forename: Jemima C
authors.initials: JC
authors.lastname: Thomas
authors.forename: Judith L
authors.initials: JL
authors.lastname: Green
authors.forename: Ronald I
authors.initials: RI
authors.lastname: Howson
authors.forename: Peter
authors.initials: P
authors.lastname: Simpson
authors.forename: David K
authors.initials: DK
authors.lastname: Moss
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Martin
authors.forename: Anthony A
authors.initials: AA
authors.lastname: Holder
authors.forename: Ernesto
authors.initials: E
authors.lastname: Cota
authors.forename: Edward W
authors.initials: EW
authors.lastname: Tate
mesh_terms: D000595:Amino Acid Sequence; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000378:metabolism*; D006790:Host-Parasite Interactions / Q000502:physiology; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D046912:Multiprotein Complexes / Q000737:chemistry / Q000378:metabolism; D009218:Myosins / Q000737:chemistry / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010963:Plasmodium falciparum / Q000502:physiology*; D015800:Protozoan Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D046912:Multiprotein Complexes; D015800:Protozoan Proteins; D009218:Myosins