title: The usefulness of toluidine staining as a diagnostic tool for precancerous and cancerous oropharyngeal and oral cavity lesions.
abstract: Toluidine blue stain is used as a marker to differentiate lesions at high risk of progression in order to improve early diagnosis of oropharyngeal carcinomas. This study focused on 45 oral mucosal lesions in 32 patients (13 female, 19 male). In 9 cases, multiple biopsies were collected. Of the 45 lesions examined, 26 (57.0%) were defined clinically benign, while 19 (42.3%) were defined as suspected lesions (premalignant or malignant). According to the clinical examination, the sensitivity was 53% (16/30) and for toluidine blue staining 96.2% (26/27) (p = 0.0007). The specificity was 80% (12/15) for clinical examination and 77.7% (14/15) for toluidine blue staining (p = 0.79). In conclusion toluidine blue stain has been shown to be a reliable aid when clinical examination is unable to differentiate lesions at high risk of progression and then it improves early diagnosis for oral cavity and oropharyngeal cancer.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Magna Graecia University of Catanzaro, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Allegra
authors.forename: N
authors.initials: N
authors.lastname: Lombardo
authors.forename: L
authors.initials: L
authors.lastname: Puzzo
authors.forename: A
authors.initials: A
authors.lastname: Garozzo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000473:pathology*; D009959:Oropharyngeal Neoplasms / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology*; D011237:Predictive Value of Tests; D015995:Prevalence; D014048:Tolonium Chloride
chemical_list: D014048:Tolonium Chloride