Hyaluronic acid binding and acrosin activity are decreased in sperm from men with spinal cord injury.
In this study, acrosin activity and hyaluronic acid binding were compared in sperm from men with spinal cord injury versus sperm from healthy controls. The results showed statistically significantly lower acrosin activity and statistically significantly lower hyaluronic acid binding in spinal cord injured patients compared with controls, indicating functional impairments that may diminish the capacity of the sperm to fertilize oocytes.
Iremashvili
Viacheslav
V
The Miami Project to Cure Paralysis, Department of Urology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Brackett
Nancy L
NL
Ibrahim
Emad
E
Aballa
Teodoro C
TC
Bruck
Darren
D
Lynne
Charles M
CM
D000176:Acrosin / Q000378:metabolism*; D000328:Adult; D016022:Case-Control Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism*; D007248:Infertility, Male / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D013081:Sperm Motility / Q000502:physiology; D013084:Sperm-Ovum Interactions / Q000502:physiology; D013094:Spermatozoa / Q000378:metabolism*; D013119:Spinal Cord Injuries / Q000378:metabolism*
D006820:Hyaluronic Acid; D000176:Acrosin