Latest insights into the anticancer activity of gold(III)-dithiocarbamato complexes.
In this review paper we aim at giving a detailed overview on our research work devoted to the design of gold-based anticancer agents. In particular, during the last decade, we have been developing some gold(III)-dithiocarbamato derivates showing outstanding in vitro and in vivo antitumor properties and reduced, or even no, systemic and renal toxicity, compared to the reference clinically-established anticancer drug cisplatin. Starting from the rationale behind our investigations, we here summarize the results achieved so far, focusing on the latest in-depth mechanistic studies that have recently provided insights into their mechanism of action, thus opening up new prospects for further pharmacological testing and, hopefully, to enter clinical trials.
Ronconi
Luca
L
Department of Chemical Sciences, University of Padova, Padova, Italy.
Aldinucci
Donatella
D
Dou
Q Ping
QP
Fregona
Dolores
D
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002945:Cisplatin / Q000009:adverse effects; D004247:DNA / Q000378:metabolism; D015195:Drug Design; D019008:Drug Resistance, Neoplasm; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007668:Kidney / Q000187:drug effects; D050607:Organogold Compounds / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D061988:Proteasome Inhibitors; D017382:Reactive Oxygen Species / Q000378:metabolism; D012995:Solubility; D013859:Thiocarbamates / Q000737:chemistry / Q000494:pharmacology*; D013880:Thioredoxin-Disulfide Reductase / Q000037:antagonists & inhibitors; D025801:Ubiquitin / Q000037:antagonists & inhibitors
D000970:Antineoplastic Agents; D050607:Organogold Compounds; D061988:Proteasome Inhibitors; D017382:Reactive Oxygen Species; D013859:Thiocarbamates; D025801:Ubiquitin; D004247:DNA; D013880:Thioredoxin-Disulfide Reductase; D002945:Cisplatin