The heat shock connection of metabolic stress and dietary restriction.
Molecular chaperones and the heat shock response guard and modulate protein conformation, protect proteins from misfolding and aggregation, and maintain signalling and organellar networks. Overnutrition and the metabolic syndrome represent a pro-aging condition, and dietary restriction is the most robust environmental intervention that induces longevity from yeast to mammals. In recent years a considerable effort has been made to elucidate the signaling pathways involved in metabolic signaling. Here we review the current understanding on the connection between metabolic stress, dietary restriction and the heat shock response and highlight results showing chaperone induction as a promising therapeutic strategy to promote healthy aging and to prevent metabolic disorders.
Dancsó
Balázs
B
Department of Medical Chemistry, Semmelweis University, Budapest, Hungary.
Spiró
Zoltán
Z
Arslan
Mehmet Alper
MA
Nguyen
Minh Tú
MT
Papp
Diána
D
Csermely
Péter
P
Soti
Csaba
C
D000818:Animals; D031204:Caloric Restriction; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008136:Longevity / Q000235:genetics / Q000502:physiology; D008659:Metabolic Diseases / Q000378:metabolism* / Q000517:prevention & control; D015398:Signal Transduction; D013312:Stress, Physiological / Q000235:genetics / Q000502:physiology
D006360:Heat-Shock Proteins