Promoting implantation by local injury to the endometrium.
OBJECTIVE
To evaluate the association between endometrial injury, implantation and pregnancy rate.


METHODS
We performed a literature search using the keywords endometrial injury, local endometrial injury, endometrial biopsy, endometrial receptivity, implantation, in vitro fertilization, and implantation failure and conducted the search in Medline, EMBASE, and Cochrane Database of systematic reviews.


METHODS
None.


METHODS
None.


METHODS
None.


METHODS
None.


RESULTS
Clinical and basic science data regarding the association between endometrial injury and improved implantation rate are limited. However, current evidence suggests that endometrial injury before IVF among women with previous repeated IVF failure is associated with increased rates of implantation, clinical pregnancy, and live birth.


CONCLUSIONS
Endometrial injury may have a beneficial role in implantation and improve the pregnancy rate. However, there are still many unanswered question including patients selection, timing, technique and number of endometrial biopsies needed.
Almog
Benjamin
B
Department of Obstetrics and Gynecology, McGill University, Montreal, Quebec, Canada.
Shalom-Paz
Einat
E
Dufort
Daniel
D
Tulandi
Togas
T
D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000209:etiology; D000818:Animals; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D010064:Embryo Implantation / Q000502:physiology*; D004717:Endometrium / Q000293:injuries* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D011247:Pregnancy; D011256:Pregnancy Outcome