The limits of agreement and the intraclass correlation coefficient may be inconsistent in the interpretation of agreement.
OBJECTIVE
To compare the interpretation of agreement in the prediction of neonatal outcome variables, using the limits of agreement (LA) and the intraclass correlation coefficient (ICC).


METHODS
Three obstetricians were asked to predict neonatal outcomes independently based on the evaluation of intrapartum cardiotocographic tracings. Interobserver agreement was assessed with the LA and the ICC, and the results obtained were interpreted by six clinicians and six statisticians on a scale that established agreement as very poor, poor, fair, good, or very good.


RESULTS
Interpretation of the LA results was less consensual than the ICC results, with proportions of agreement of 0.36 (95% confidence interval [CI]: 0.28-0.44) vs. 0.63 (95% CI: 0.54-0.73), respectively. LA results suggested a fair to good agreement among obstetricians, whereas interpretation of ICC results suggested a poor to fair agreement. LA results were more plausible with reality, suggesting that obstetricians predicted neonatal outcomes better than randomly generated values, whereas it was not always the case with the ICC.


CONCLUSIONS
LA and ICC can provide inconsistent results in agreement studies. Accordingly, in the absence of better strategies to assess agreement, both should be used for this purpose, but their results need to be interpreted with caution keeping their respective limitations in mind.
Costa-Santos
Cristina
C
Biostatistics and Medical Informatics Department, Faculty of Medicine, University of Porto, Porto, Portugal. csantos@med.up.pt
Bernardes
João
J
Ayres-de-Campos
Diogo
D
Costa
Antónia
A
Amorim-Costa
Célia
C
Costa
Célia
C
D001034:Apgar Score; D015148:Cardiotocography / Q000592:standards*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D015588:Observer Variation; D009774:Obstetrics / Q000592:standards*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology; D014469:Umbilical Arteries