Immobile BCRs: the safety on the signal trigger.
B cell receptor (BCR)-mediated tonic signals are important for B cell survival and development. In this issue of Immunity, Treanor et al. (2010) show that triggering of downstream responses is kept in check with BCR immobilization by actin.
Sasaki
Yoshiteru
Y
Laboratory for Stem Cell Biology, Riken Center for Developmental Biology, Kobe, 650-0047, Japan.
Kurosaki
Tomohiro
T
D000199:Actins / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology; D051925:CD79 Antigens / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D003598:Cytoskeletal Proteins / Q000276:immunology / Q000378:metabolism*; D003599:Cytoskeleton / Q000187:drug effects / Q000235:genetics; D007152:Immunologic Capping; D051379:Mice; D008856:Microscopy, Fluorescence; D011485:Protein Binding; D015202:Protein Engineering; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D053778:Thiazolidines / Q000494:pharmacology; D000099149:Ezrin
D000199:Actins; D019086:Bridged Bicyclo Compounds, Heterocyclic; D051925:CD79 Antigens; D003598:Cytoskeletal Proteins; D053778:Thiazolidines; D000099149:Ezrin; C037067:latrunculin A