title: A study of the biological effects of modulated 6 MV radiation fields.
abstract: The delivery of spatially modulated radiation fields has been shown to impact on in vitro cell survival responses. To study the effect of modulated fields on cell survival, dose response curves were determined for human DU-145 prostate, T98G glioma tumour cells and normal primary AGO-1552 fibroblast cells exposed to modulated and non-modulated field configurations delivered using a 6 MV Linac with multi-leaf collimator. When exposed to uniform fields delivered as a non-modulated or modulated configuration, no significant differences in survival were observed with the exception of DU-145 cells at a dose of 8 Gy (p = 0.024). Survival responses were determined for exposure to non-uniform-modulated beams in DU-145 and T98G and showed no deviation from the survival response observed following uniform non-modulated exposures. The results of these experiments indicate no major deviation in response to modulated fields compared to uniform exposures.
authors.affiliation: Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast, BT9 7BL, Northern Ireland, UK. k.butterworth@qub.ac.uk
authors.forename: Karl T
authors.initials: KT
authors.lastname: Butterworth
authors.forename: Conor K
authors.initials: CK
authors.lastname: McGarry
authors.forename: Joe M
authors.initials: JM
authors.lastname: O'Sullivan
authors.forename: Alan R
authors.initials: AR
authors.lastname: Hounsell
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Prise
mesh_terms: D002470:Cell Survival / Q000528:radiation effects; D002478:Cells, Cultured; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000166:cytology / Q000000981:diagnostic imaging / Q000378:metabolism; D005910:Glioma / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D011877:Radionuclide Imaging; D011879:Radiotherapy Dosage; D050397:Radiotherapy, Intensity-Modulated / Q000379:methods*; D015203:Reproducibility of Results; D013997:Time Factors