title: Cystathionine beta-synthase 844Ins68 polymorphism is not associated with the levels of homocysteine and cysteine in an Indian population.
abstract: Cystathionine beta-synthase (CBS) is a key enzyme that plays a critical role in homocysteine metabolism and intracellular redox balance. We have analysed the association of the CBS 844Ins68 polymorphism alone and in combination with methylenetetrahydrofolate reductase (MTHFR C677T) and choline dehydrogenase (CHDH A119C) polymorphisms (the two polymorphisms recently shown to be associated with levels of homocysteine) with homocysteine, cysteine, folate and vitamin B(12) in 817 individuals (397 patients with coronary artery disease and 420 controls). The CBS 844Ins68 polymorphism alone or in combination with MTHFR C677T and CHDH A119C polymorphisms was not significantly associated with any of the biochemical variables studied.
authors.affiliation: Institute of Genomics and Integrative Biology, Delhi, India.
authors.forename: Jitender
authors.initials: J
authors.lastname: Kumar
authors.forename: Gaurav
authors.initials: G
authors.lastname: Garg
authors.forename: Ganesan
authors.initials: G
authors.lastname: Karthikeyan
authors.forename: Shantanu
authors.initials: S
authors.lastname: Sengupta
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003541:Cystathionine beta-Synthase / Q000097:blood*; D003545:Cysteine / Q000097:blood*; D005260:Female; D005787:Gene Frequency; D006579:Heterozygote; D006710:Homocysteine / Q000097:blood*; D006720:Homozygote; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D011110:Polymorphism, Genetic
chemical_list: D006710:Homocysteine; D003541:Cystathionine beta-Synthase; D003545:Cysteine