title: Endoscopic therapy of small-bowel polyps by double-balloon enteroscopy in patients with Peutz-Jeghers syndrome.
abstract: BACKGROUND
  Peutz-Jeghers syndrome (PJS) is a hereditary disorder characterized by mucocutaneous pigmentations and hamartomatous polyps mainly in the small bowel. These polyps may cause complications such as intussusception.
  
  
  OBJECTIVE
  To assess therapeutic efficacy and safety of double-balloon enteroscopy (DBE) for detection and treatment of small-bowel polyps in patients with PJS.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  Tertiary-care referral center.
  
  
  METHODS
  This study involved 13 patients with PJS, defined as a proven STK11 gene mutation or according to international diagnostic criteria.
  
  
  METHODS
  DBE with enteroscopic removal of pedunculated polyps of > or =10 mm.
  
  
  METHODS
  Location, number and size of small-bowel polyps, polypectomy data, and complications and long-term complications associated with development of small-intestine polyps.
  
  
  RESULTS
  Thirteen patients with PJS (8 male, mean age 31 years) underwent 29 DBE procedures. Ten patients (77%) had a history of partial small-bowel resection because of small-bowel polyps. Small-bowel polyps were found in all 13 patients. The majority of polyps (94%) were located in the proximal jejunum. A total of 82 polyps of > or =10 mm were detected, and 79 (96%) were endoscopically removed without complications. After the introduction of DBE, no small-intestine-polyp-related complications occurred during a follow-up period of 356 person-months.
  
  
  CONCLUSIONS
  Small number of patients.
  
  
  CONCLUSIONS
  DBE is clinically useful and safe for diagnosis and therapy of small-bowel polyps in patients with PJS, even in patients with a history of extensive abdominal surgery. DBE may decrease the need for laparotomy in patients with PJS.
authors.affiliation: Department of Gastroenterology and Hepatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands.
authors.forename: Hong
authors.initials: H
authors.lastname: Gao
authors.forename: Margot G
authors.initials: MG
authors.lastname: van Lier
authors.forename: Jan Werner
authors.initials: JW
authors.lastname: Poley
authors.forename: Ernst J
authors.initials: EJ
authors.lastname: Kuipers
authors.forename: Monique E
authors.initials: ME
authors.lastname: van Leerdam
authors.forename: Peter B
authors.initials: PB
authors.lastname: Mensink
mesh_terms: D000091162:AMP-Activated Protein Kinase Kinases; D000293:Adolescent; D000328:Adult; D002648:Child; D015331:Cohort Studies; D020776:Endoscopes, Gastrointestinal; D005260:Female; D005838:Genotype; D006801:Humans; D007078:Ileal Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D007580:Jejunal Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D008297:Male; D009154:Mutation; D010580:Peutz-Jeghers Syndrome / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D011446:Prospective Studies; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D017346:Protein Serine-Threonine Kinases; C109790:STK11 protein, human; D000091162:AMP-Activated Protein Kinase Kinases