title: Auditory-evoked response analysis in Brazilian patients with sickle cell disease.
abstract: The objective of the present study was to evaluate the integrity of the peripheral and central auditory systems of sickle cell disease (SCD) patients, through electrophysiological evaluation utilizing auditory evoked potentials, and comparing the results obtained in SCD patients with individuals without SCD. A total of 80 individuals were evaluated: 40 SCD patients; and 40 healthy age- and sex-matched controls. Brainstem auditory evoked response (BAER) was used to check neural integrity and electrophysiological thresholds, and cognitive potential (P300) to analyse the auditory selective attention. Despite the exclusion of individuals with comorbidities typical of SCD, the predominance of hearing loss among the patients was detected in 16 ears (20%). The absolute latencies of the BAER were within the expected range but the SCD group showed a small but statistically significant reduction of the interpeaks I-V, indicative of cochlear alteration. P300 latency and amplitude were adequate for both groups suggesting the absence of central auditory system abnormalities. The present findings suggest that SCD causes variable degree of cochlear abnormalities without evidence of neural problems.
authors.affiliation: Centro Universitário Planalto do Distrito Federal-UNIPLAN-Audiology Unit, Brasilia, DF, Brazil. isabella.monts@gmail.com
authors.forename: Isabella Monteiro
authors.initials: IM
authors.lastname: de Castro Silva
authors.forename: Isis Quezado
authors.initials: IQ
authors.lastname: Magalhães
authors.forename: Raquel Alves
authors.initials: RA
authors.lastname: Toscano
authors.forename: Lenora
authors.initials: L
authors.lastname: Gandolfi
authors.forename: Riccardo
authors.initials: R
authors.lastname: Pratesi
mesh_terms: D000158:Acoustic Impedance Tests; D000161:Acoustic Stimulation; D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications / Q000503:physiopathology*; D001306:Auditory Pathways / Q000503:physiopathology*; D001938:Brazil; D016022:Case-Control Studies; D002648:Child; D003051:Cochlea / Q000503:physiopathology; D003071:Cognition; D018913:Event-Related Potentials, P300; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D034381:Hearing Loss / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D008297:Male; D011930:Reaction Time; D012022:Reflex, Acoustic; D012720:Severity of Illness Index; D009435:Synaptic Transmission; D013997:Time Factors; D055815:Young Adult