title: Drug-induced eosinophilic pneumonia with pulmonary alveolar hemorrhage caused by benzbromarone.
abstract: A 51-year-old man was admitted to our hospital with cough, hemosputum, dyspnea and chest pain. Chest high-resolution computed tomography (HRCT) revealed diffuse ground-glass opacities in both lungs with peripheral predominance. Bronchoalveolar lavage fluid was fresh-bloody and analysis indicated an increase in the eosinophil proportion. Benzbromarone-induced lymphocyte stimulation test was positive. Therefore, the patient was diagnosed as having drug-induced eosinophilic pneumonia with pulmonary alveolar hemorrhage caused by benzbromarone. After discontinuation of benzbromarone and administration of corticosteroids, chest HRCT images and respiratory manifestation improved. Here, we report this rare case of benzbromarone-induced eosinophilic pneumonia with pulmonary alveolar hemorrhage.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University School of Medicine.
authors.forename: Atsuko
authors.initials: A
authors.lastname: Hara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mukae
authors.forename: Shintaro
authors.initials: S
authors.lastname: Hara
authors.forename: Misato
authors.initials: M
authors.lastname: Amenomori
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishimoto
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kakugawa
authors.forename: Hanako
authors.initials: H
authors.lastname: Fujita
authors.forename: Noriho
authors.initials: N
authors.lastname: Sakamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ishimatsu
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno
mesh_terms: D001553:Benzbromarone / Q000009:adverse effects* / Q000627:therapeutic use; D001992:Bronchoalveolar Lavage Fluid; D006073:Gout / Q000188:drug therapy; D006470:Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008171:Lung Diseases / Q000139:chemically induced* / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011657:Pulmonary Eosinophilia / Q000139:chemically induced* / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed; D014528:Uricosuric Agents / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D014528:Uricosuric Agents; D001553:Benzbromarone