title: Supramolecular hydrogels exhibiting fast in situ gel forming and adjustable degradation properties.
abstract: Fast in situ forming supramolecular hydrogels consisted of the tyramine-conjugated supramolecular structures and chitosan derivative were prepared via an enzymatic reaction with horseradish peroxidase (HRP) and hydrogen peroxide (H(2)O(2)). The gel formation was varied within a time period of 5 s to 10 min by controlling the concentrations of HRP, H(2)O(2), and polymers. Tyramine conjugation at different sites of the supramolecular structure resulted in significant changes in physical properties and the degradation time of the hydrogels that were confirmed by water uptake, compressive strength and degradation tests. In addition, the hydrogels showed a good cytocompatibility in vitro. These hydrogels could be promising injectable biomaterials with adjustable degradation times to control both the cellular behaviors as a regenerative cell matrix and the drug release behavior as a drug delivery vehicle.
authors.affiliation: Department of Molecular Science and Technology, Ajou University, 5 Wonchon, Yeoungtong, Suwon 443-749, Republic of Korea.
authors.forename: Ngoc Quyen
authors.initials: NQ
authors.lastname: Tran
authors.forename: Yoon Ki
authors.initials: YK
authors.lastname: Joung
authors.forename: Eugene
authors.initials: E
authors.lastname: Lih
authors.forename: Kyung Min
authors.initials: KM
authors.lastname: Park
authors.forename: Ki Dong
authors.initials: KD
authors.lastname: Park
mesh_terms: D000818:Animals; D048271:Chitosan / Q000737:chemistry; D006735:Horseradish Peroxidase / Q000737:chemistry; D020100:Hydrogels; D006861:Hydrogen Peroxide / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D014439:Tyramine / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D020100:Hydrogels; D048271:Chitosan; D006861:Hydrogen Peroxide; D006735:Horseradish Peroxidase; D014439:Tyramine