Cell responses to oxidative stressors.
Stress is a stimulus or a succession of stimuli tending to disrupt the homeostasis of an organism. An organism is consisting of a multitude of cells that singly undergo the effects of external factors that disturb or upset their homeostatic regulation. Stimuli acting as potential stressors are numerous, and include physical agents (ionizing radiation), non-physiological oxygen levels (hypoxia, hyperoxia) and chemotherapeutics. Lastly, also senescence, a physiological process occurring in all organisms, can be considered as a potential stressor. The cell response to multiple oxidative stresses involves mitochondria, since these organelles represent the major source of Reactive Oxygen Species (ROS) that drive the occurrence of pathological conditions and ageing by activating specific signalling pathways. Nevertheless, under physiological conditions the cells are able to exert an antioxidant response which, controlling ROS/Reactive Nitrogen Species (RNS) homeostasis, is involved in mediating cell differentiation, proliferation and migration. Thus, this review focuses the attention to the role played by mitochondria in the physiological and non-physiological signalling responses of eukaryotic cells to some oxidative stresses, in order to identify potential therapeutic targets to counteract oxidative stress effects and mitochondrial-related pathologies.
Cataldi
Amelia
A
Dipartimento di Biomorfologia, Cattedra di Anatomia Umana, Facoltà di Farmacia, Università G. d'Annunzio, Chieti-Pescara, Via dei Vestini, 6, 66100, Chieti - Italy. cataldi@unich.it
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D016922:Cellular Senescence / Q000187:drug effects / Q000528:radiation effects; D000242:Cyclic AMP / Q000378:metabolism; D005057:Eukaryotic Cells / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism / Q000528:radiation effects; D006706:Homeostasis / Q000187:drug effects* / Q000528:radiation effects*; D006801:Humans; D051793:Hypoxia-Inducible Factor 1 / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects*; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects / Q000528:radiation effects; D010101:Oxygen Consumption / Q000187:drug effects / Q000528:radiation effects; D011493:Protein Kinase C / Q000378:metabolism; D011839:Radiation, Ionizing; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000528:radiation effects; D019098:Telomerase / Q000378:metabolism
D000970:Antineoplastic Agents; D051793:Hypoxia-Inducible Factor 1; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D000242:Cyclic AMP; D011493:Protein Kinase C; D019098:Telomerase