Double high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation for primary disseminated medulloblastoma: a report of 3 cases.
We performed double high-dose chemotherapy followed by peripheral blood stem cell transplantation (PBSCT) in 3 children with medulloblastoma and primary leptomeningial dissemination, including spinal metastasis. After resection of the main tumor mass, 30.6 Gy whole craniospinal radiation therapy and 4 or 5 courses of conventional chemotherapy with vincristine (1.5 mg/m), carboplatin (560 mg/m), ifosfamide (9000 mg/m), and etoposide (500 mg/m), and 2 courses of high-dose thiotepa (680 mg/m) and melphalan (240 mg/m) therapy with PBSCT were administered. Two patients with low erythroblastic leukemia viral oncogene homolog 2 (ERBB2) gene expression achieved long-term survival (41 mo and 40 mo) but the patient with high ERBB2 expression relapsed 9 months after the second PBSCT.
Aihara
Yasuo
Y
Departments of Neurosurgery, Tokyo Women's Medical University Medical Center East, Tokyo, Japan.
Tsuruta
Toshihisa
T
Kawamata
Takakazu
T
Kanno
Hitoshi
H
Maebayashi
Katsuya
K
Sakauchi
Masako
M
Wada
Emiko
E
Osawa
Makiko
M
Fujii
Hisaichi
H
Kubo
Osami
O
Hori
Tomokatsu
T
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002528:Cerebellar Neoplasms / Q000473:pathology / Q000628:therapy*; D002648:Child; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000473:pathology / Q000628:therapy*; D036102:Peripheral Blood Stem Cell Transplantation / Q000009:adverse effects; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D014182:Transplantation, Autologous
D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human