title: Toxic epidermal necrolysis-like cutaneous lupus erythematosus: A series of three patients.
abstract: Toxic epidermal necrolysis-like lesions have been described in the setting of lupus erythematosus, and have been considered as a specific hyperacute variant of cutaneous lupus erythematosus, with features different from classical drug-related toxic epidermal necrolysis. We report here a series of three patients with lupus erythematosus who presented with severe worsening of their cutaneous disease in a toxic epidermal necrolysis-like fashion. We compared these cases with cases reported previously. Based on this discussion, we speculate that some of these patients may have classical drug-related toxic epidermal necrolysis rather than lupus erythematosus-related toxic epidermal necrolysis.
authors.affiliation: Department of Dermatology, University of Sao Paulo, Brazil. gercisneros90@yahoo.com
authors.forename: Claudia G C
authors.initials: CG
authors.lastname: Cisneros
authors.forename: Ricardo
authors.initials: R
authors.lastname: Romiti
authors.forename: Cláudia G
authors.initials: CG
authors.lastname: Santi
authors.forename: Valéria
authors.initials: V
authors.lastname: Aoki
authors.forename: Neusa Y S
authors.initials: NY
authors.lastname: Valente
authors.forename: Marcello M S
authors.initials: MM
authors.lastname: Nico
mesh_terms: D000293:Adolescent; D001379:Azathioprine / Q000627:therapeutic use; D002738:Chloroquine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008178:Lupus Erythematosus, Cutaneous / Q000188:drug therapy / Q000473:pathology*; D011239:Prednisolone / Q000627:therapeutic use; D012720:Severity of Illness Index; D012867:Skin / Q000187:drug effects / Q000473:pathology*; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; C023676:chloroquine diphosphate; D002738:Chloroquine; D011239:Prednisolone; D001379:Azathioprine