Impact of the new lung cancer staging system for a predominantly advanced-disease patient population.
BACKGROUND
To investigate the feasibility and clinical impact of the 7th edition of the "Tumor, Node, Metastasis" (TNM) classification scheme in lung cancer as proposed by the International Association for the Study of Lung Cancer (IASLC) for non-small cell lung cancer.


METHODS
We evaluated the feasibility of the new staging system in our routine biweekly multidisciplinary lung cancer staging conference compared with the 6th TNM staging in a prospective manner from April 2008 to June 2009. The impact of IASLC staging versus the 6th TNM staging was observed at three levels: change in substaging, staging, and clinical management (based on the discussion within the staging conference).


RESULTS
From 348 patients discussed during these conferences, 226 eligible non-small cell lung cancer patients newly diagnosed within the study period were reviewed and clinically staged. The majority were elderly (median age, 67 years) and men (58%). Of these, 23 patients had different staging, and four patients had different substaging in the IASLC staging compared with the 6th TNM staging. An impact on clinical management was seen in 2.7% (6 of 226) of these patients because of coding ipsilateral different-lobe metastasis as T4 instead of M1.


CONCLUSIONS
The new staging system was clinically feasible and resulted in some (27 of 226, 12%) differences in staging. An impact on clinical decision making was occasionally seen within our institutional practice. Further studies are needed to investigate the comprehensive and long-term impact of the new staging system.
Chien
Chun-Ru
CR
Department of Radiation Oncology, China Medical University Hospital, Taichung, Taiwan.
Yang
Su-Tso
ST
Chen
Chih-Yi
CY
Fang
Hsin-Yuan
HY
Tu
Chih-Yen
CY
Tseng
Guan-Chin
GC
Yu
Yang-Ho
YH
Chen
Hung-Jen
HJ
Ho
Chih-Te
CT
Hsieh
Ching-Yun
CY
Chen
Hsiang-Ni
HN
Chen
Pin-Ru
PR
Liu
Juhn-Cherng
JC
Wang
Yao-Ching
YC
Wu
Hui-Hua
HH
Hsia
Te-Chun
TC
D000230:Adenocarcinoma / Q000145:classification / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000145:classification / Q000473:pathology* / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000145:classification / Q000473:pathology* / Q000601:surgery; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000145:classification / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D015996:Survival Rate