title: Photoinduced DNA cleavage by formation of ROS from oxygen with a neurotransmitter and aromatic amino acids.
abstract: UV-B photoirradiation of a neurotransmitter (serotonin) and aromatic amino acids (tryptophan and tyrosine) with oxygen results in DNA cleavage by generation of reactive oxygen species (ROS) as demonstrated by agarose gel electrophoresis with pBR 322 DNA, ESR and laser flash photolysis measurements.
authors.affiliation: Department of Material and Life Science, Graduate School of Engineering, Osaka University, SORST, Japan Science and Technology Agency (JST), Yamada-oka 2-1, Suita, Osaka 565-0871, Japan.
authors.forename: Tomonori
authors.initials: T
authors.lastname: Kawashima
authors.forename: Kei
authors.initials: K
authors.lastname: Ohkubo
authors.forename: Shunichi
authors.initials: S
authors.lastname: Fukuzumi
mesh_terms: D053837:DNA Cleavage / Q000528:radiation effects*; D010100:Oxygen / Q000378:metabolism*; D055668:Photochemical Processes; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism*; D014466:Ultraviolet Rays
chemical_list: D017382:Reactive Oxygen Species; D012701:Serotonin; D014443:Tyrosine; D014364:Tryptophan; D010100:Oxygen