Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry.
High resolution localized surface plasmon resonance (HR-LSPR) sensors were combined with matrix assisted laser desorption ionization mass spectrometry (MALDI-MS) for the first time. LSPR sensors provide real-time label-free detection of molecular adsorption. Subsequent MALDI-MS analysis enables identification of the adsorbed molecules. This synergistic LSPR-MS approach was applied to the detection and identification of amyloid beta oligomers which play an important role in the molecular pathogenesis of Alzheimer's Disease.
Anker
Jeffrey N
JN
Department of Chemistry, Northwestern University, 214x5 Sheridan Road, Evanston, IL 60208, USA.. ; Tel: 747-491-3516;
Hall
W Paige
WP
Lambert
Mary P
MP
Velasco
Pauline T
PT
Mrksich
Milan
M
Klein
William L
WL
Van Duyne
Richard P
RP