title: [Polypronuclear zygotes and clinical pregnancy after IVF].
abstract: OBJECTIVE
  To study the relationship between the percentage of polypronuclear zygotes and clinical pregnancy following IVF.
  
  
  METHODS
  We collected the data of 954 IVF cycles, and according the percentage of polypronuclear zygotes in the IVF cycles, allocated them to Groups A (without polypronuclear zygotes) , B (with < 30% polypronuclear zygotes) and C (with > or = 30% polypronuclear zygotes). Then we analyzed the relationship between the percentage of polypronuclear zygotes and the rate of clinical pregnancy.
  
  
  RESULTS
  Compared with Group A, Group C showed a significantly lower rate of clinical pregnancy (43.2% vs 28. 1%, P < 0.05), while Group B exhibited a markedly higher rate (43.2% vs 52.36%, P < 0.05) and obviously decreased polypronuclear zygote formation with the increase of age (35.6% vs 24.1%, P < 0.05).
  
  
  CONCLUSIONS
  The percentage of polypronuclear zygotes in IVF cycles may serve as a prognostic indicator of the clinical outcome.
authors.affiliation: Center of Human Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China.
authors.forename: Hui-Rong
authors.initials: HR
authors.lastname: Yin
authors.forename: Xiao-Qiao
authors.initials: XQ
authors.lastname: Qian
authors.forename: Ling-Bo
authors.initials: LB
authors.lastname: Cai
authors.forename: Ting
authors.initials: T
authors.lastname: Feng
authors.forename: Zheng-Jie
authors.initials: ZJ
authors.lastname: Yan
authors.forename: Long
authors.initials: L
authors.lastname: Ma
authors.forename: Jia-Yin
authors.initials: JY
authors.lastname: Liu
mesh_terms: D000328:Adult; D000367:Age Factors; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D015053:Zygote