[Thermal stability evaluation of some W/O/W double emulsions containing 1% piroxicam by rheological measurements].
The aim of this work was to evaluate thermal stability of some W/O/W concentrated double emulsions (with 80% dispersed phase) containing 1% piroxicam following their theological behaviour at various temperatures. W/O/W double emulsions containing 1% piroxicam were prepared using the two-step procedure.


RESULTS
The variable parameter of formulations was the hydrophilic macromolecule compound dispersed in the internal and external aqueous phases (hydroxyethylcellulose and Carbopol 940). Rheological behaviour and viscosity of the obtained W/O/W double emulsions was measured at 15 degrees C, 20 degrees C, 25 degrees C, 30 degrees C and 35 degrees C respectively, after preparation. The obtained results demonstrated that the studied W1/O/W2 double emulsions containing 1% piroxicam were stable under applied thermal stress, although they exhibited some differences in rheological properties caused by formulation variable.
Vlaia
Lavinia
L
Facultatea de Farmacie, Disciplina de Tehnologie Farmaceutică, Universitatea de Medicină si Farmacie "Victor Babeă" Timişoara.
Vlaia
V
V
Olariu
Ioana
I
Hegheş
Alina
A
Miclea
Lenuţa-Maria
LM
Coneac
Georgeta
G
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D004655:Emulsions / Q000737:chemistry; D006801:Humans; D010894:Piroxicam / Q000737:chemistry*; D012212:Rheology / Q000379:methods*; D013696:Temperature; D014783:Viscosity; D014867:Water / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004655:Emulsions; D014867:Water; D010894:Piroxicam