The origin of pre-eclampsia: from decidual "hyperoxia" to late hypoxia.
Normal gestation implants on a relatively hypoxic deciduas so that trophoblast deeply invades endometrium and angiogenesis seeks for oxygen supply. If implantation occurs before those hypoxic conditions occur, trophoblast invasion is defective, due to the relatively high oxygen tension in the decidual environment, laying the foundations for subsequent pre-eclampsia.
Tranquilli
Andrea L
AL
Department of Clinical Sciences, Section of Women's Health Sciences, Università Politecnica Marche, Ancona, Italy. a.l.tranquilli@univpm.it
Landi
Beatrice
B
D002248:Carbon Monoxide / Q000633:toxicity; D005260:Female; D006801:Humans; D018496:Hyperoxia / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D020738:Leptin / Q000502:physiology; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000209:etiology* / Q000503:physiopathology; D011247:Pregnancy; D012907:Smoking
D020738:Leptin; D002248:Carbon Monoxide