Chronic urticaria of neonatal onset: a potential sign of autoinflammation.
We present a 6 year old boy with chronic urticaria of neonatal onset associated in childhood with features of neurological and joint inflammation. Genetic analysis confirmed the diagnosis of neonatal onset multi-inflammatory disorder (NOMID). Daily subcutaneous anti-IL-1 receptor antagonist therapy resulted in a dramatic and sustained amelioration of systemic inflammation. NOMID must be considered in any child with chronic urticaria of neonatal/infantile onset, particularly if associated with joint and/or neurological inflammation.
Mehr
Sam
S
Departments of Allergy and Immunology, The Children's Hospital at Westmead, University of Sydney, Sydney, New South Wales, Australia.
Jones
Kristi J
KJ
Singh-Grewal
Davinder
D
Aksentijevich
Ivona
I
Kakakios
Alyson
A
D001315:Australia; D001327:Autoimmune Diseases / Q000175:diagnosis*; D002675:Child, Preschool; D002908:Chronic Disease; D006801:Humans; D008297:Male; D014581:Urticaria / Q000175:diagnosis / Q000503:physiopathology*