Ultrasmall particle of iron oxide--RGD peptidomimetic conjugate: synthesis and characterisation.
Ultrasmall particles of iron oxide (USPIOs) coated with 3,3'-bis(phosphonate)propionic acid were covalently coupled to a home-made Arg-Gly-Asp (RGD) peptidomimetic molecule via a short oligoethylene-glycol (OEG) spacer. The conjugation rate was measured by X-ray photoelectron spectroscopy (XPS). The particle size and magnetic characteristics were kept. Our novel conjugate targeted efficiently Jurkat cells (increase of 229% vs the control).
Rerat
Vincent
V
Unité de Chimie Organique et Médicinale, Université Catholique de Louvain, Bâtiment Lavoisier, Louvain-la-Neuve, Belgium.
Laurent
Sophie
S
Burtéa
Carmen
C
Driesschaert
Benoît
B
Pourcelle
Vincent
V
Vander Elst
Luce
L
Muller
Robert N
RN
Marchand-Brynaert
Jacqueline
J
D005290:Ferric Compounds / Q000737:chemistry*; D018716:Molecular Mimicry; D009842:Oligopeptides / Q000737:chemistry*; D010316:Particle Size; D013057:Spectrum Analysis / Q000379:methods; D014965:X-Rays
D005290:Ferric Compounds; D009842:Oligopeptides; C000499:ferric oxide; C047981:arginyl-glycyl-aspartic acid