title: Metastatic primary angiosarcoma of the breast in a pediatric patient with a complete response to systemic chemotherapy and definitive radiation therapy: case report and review of the literature.
abstract: We present a case of a rare malignancy, primary breast angiosarcoma, in a 15-year-old girl. She presented with a locally advanced tumor and suspected metastatic disease to the mediastinum and bones on PET imaging. The patient was treated with systemic chemotherapy and definitive radiation therapy to her left breast and achieved a complete response. She has no evidence of disease recurrence 44 months from her initial diagnosis.
authors.affiliation: Department of RadiationOncology, Emory University School of Medicine and EmoryWinship Cancer Institute, 1365 Clifton Road, NE, Atlanta, GA 30322, USA. heather@radonc.emory.org
authors.forename: Heather G
authors.initials: HG
authors.lastname: Gatcombe
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Olson
authors.forename: Natia
authors.initials: N
authors.lastname: Esiashvili
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000556:secondary / Q000628:therapy*; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006394:Hemangiosarcoma / Q000556:secondary / Q000628:therapy*; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008279:Magnetic Resonance Imaging; D008479:Mediastinal Neoplasms / Q000556:secondary / Q000628:therapy*; D011878:Radiotherapy; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D007069:Ifosfamide