[Effect of dicarbamin on postradiation leukocyte composition dynamics in peripheral blood of mice].
Effects of dicarbamin on the post-irradiation dynamics of leukocyte composition in the peripheral blood of mice have been studied upon oral administration of the drug in a single dose of 0.5, 5.0, 15.0, and 50.0 mg/kg. It is established that the drug doses of 5.0, 15.0, and 50.0 mg/kg produce statistically significant radioprotective effects. The leukocyte fall decreases due to segmented neutrophils and lymphocytes. In addition, the drug accelerates the process of restoration of the leukocyte cell numbers on the initial level.
Moiseeva
I Ia
IIa
Zinov'ev
A I
AI
Mozerova
I V
IV
Filimonov
S A
SA
D000818:Animals; D002208:Caproates; D004307:Dose-Response Relationship, Radiation; D007093:Imidazoles / Q000494:pharmacology*; D007958:Leukocyte Count; D007962:Leukocytes / Q000166:cytology / Q000528:radiation effects*; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D002208:Caproates; D007093:Imidazoles; D011837:Radiation-Protective Agents; C539419:pentanedioic acid imidazolyl ethanamide