Detection of HIV-1 at between 20 and 49 copies per milliliter by the Cobas TaqMan HIV-1 v2.0 assay is associated with higher pretherapy viral load and less time on antiretroviral therapy.
New commercial techniques for determination of the viral load (VL) in plasma are able to detect as few as 20 copies of HIV-1 RNA/ml. The relevance of this new technical threshold is uncertain. Upon multivariate analysis, factors associated with detection of VLs between 20 and 49 copies/ml by the Cobas TaqMan HIV-1 v2.0 assay in an HIV clinic were the basal VL and time on antiretroviral therapy.
Pascual-Pareja
José F
JF
Microbiology Department, Hospital Universitario 12 de Octubre, Avenida de Córdoba sn., 28041 Madrid, Spain.
Martínez-Prats
Lorena
L
Luczkowiak
Joanna
J
Fiorante
Silvana
S
Rubio
Rafael
R
Pulido
Federico
F
Otero
Joaquín R
JR
Delgado
Rafael
R
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D010949:Plasma / Q000821:virology; D012367:RNA, Viral / Q000097:blood; D011933:Reagent Kits, Diagnostic; D013997:Time Factors; D019562:Viral Load
D012367:RNA, Viral; D011933:Reagent Kits, Diagnostic