Effect of different components of triple-H therapy on cerebral perfusion in patients with aneurysmal subarachnoid haemorrhage: a systematic review.
BACKGROUND
Triple-H therapy and its separate components (hypervolemia, hemodilution, and hypertension) aim to increase cerebral perfusion in subarachnoid haemorrhage (SAH) patients with delayed cerebral ischemia. We systematically reviewed the literature on the effect of triple-H components on cerebral perfusion in SAH patients.


METHODS
We searched medical databases to identify all articles until October 2009 (except case reports) on treatment with triple-H components in SAH patients with evaluation of the treatment using cerebral blood flow (CBF in ml/100 g/min) measurement. We summarized study design, patient and intervention characteristics, and calculated differences in mean CBF before and after intervention.


RESULTS
Eleven studies (4 to 51 patients per study) were included (one randomized trial). Hemodilution did not change CBF. One of seven studies on hypervolemia showed statistically significant CBF increase compared to baseline; there was no comparable control group. Two of four studies applying hypertension and one of two applying triple-H showed significant CBF increase, none used a control group. The large heterogeneity in interventions and study populations prohibited meta-analyses.


CONCLUSIONS
There is no good evidence from controlled studies for a positive effect of triple-H or its separate components on CBF in SAH patients. In uncontrolled studies, hypertension seems to be more effective in increasing CBF than hemodilution or hypervolemia.
Dankbaar
Jan W
JW
Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, 3584CX, Netherlands. j.w.dankbaar@umcutrecht.nl
Slooter
Arjen Jc
AJ
Rinkel
Gabriel Je
GJ
Schaaf
Irene C van der
IC
D000328:Adult; D002560:Cerebrovascular Circulation; D005440:Fluid Therapy; D006438:Hemodilution; D006801:Humans; D006973:Hypertension; D008875:Middle Aged; D013345:Subarachnoid Hemorrhage / Q000503:physiopathology / Q000628:therapy*