Syntheses of water-soluble [60]fullerene derivatives and their enhancing effect on neurite outgrowth in NGF-treated PC12 cells.
Water-soluble [60]fullerene (C(60)) derivatives were synthesized to examine their bioactivities. PC12 cells were used as a model of nerve cells and the bioactivities of synthesized C(60) derivatives together with some reported ones were tested. Among the compounds tested, C(60)/(gamma-CyD)(2), C(60)-bis(gamma-CyD) (5) containing C(60)-mono(gamma-CyD) (5'), and C(60)/PVP were sufficiently soluble in water and showed an enhancing effect on the neurite outgrowth of NGF-treated PC12 cells.
Tsumoto
Hiroki
H
Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Aichi, Japan.
Kawahara
Syo
S
Fujisawa
Yuki
Y
Suzuki
Takayoshi
T
Nakagawa
Hidehiko
H
Kohda
Kohfuku
K
Miyata
Naoki
N
D000818:Animals; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology*; D020932:Nerve Growth Factor / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects*; D016716:PC12 Cells; D051381:Rats; D012995:Solubility; D014867:Water
D037741:Fullerenes; D014867:Water; D020932:Nerve Growth Factor; C069837:fullerene C60