title: Comparison of a 3-D multi-group SN particle transport code with Monte Carlo for intracavitary brachytherapy of the cervix uteri.
abstract: A patient dose distribution was calculated by a 3D multi-group S N particle transport code for intracavitary brachytherapy of the cervix uteri and compared to previously published Monte Carlo results. A Cs-137 LDR intracavitary brachytherapy CT data set was chosen from our clinical database. MCNPX version 2.5.c, was used to calculate the dose distribution. A 3D multi-group S N particle transport code, Attila version 6.1.1 was used to simulate the same patient. Each patient applicator was built in SolidWorks, a mechanical design package, and then assembled with a coordinate transformation and rotation for the patient. The SolidWorks exported applicator geometry was imported into Attila for calculation. Dose matrices were overlaid on the patient CT data set. Dose volume histograms and point doses were compared. The MCNPX calculation required 14.8 hours, whereas the Attila calculation required 22.2 minutes on a 1.8 GHz AMD Opteron CPU. Agreement between Attila and MCNPX dose calculations at the ICRU 38 points was within +/- 3%. Calculated doses to the 2 cc and 5 cc volumes of highest dose differed by not more than +/- 1.1% between the two codes. Dose and DVH overlays agreed well qualitatively. Attila can calculate dose accurately and efficiently for this Cs-137 CT-based patient geometry. Our data showed that a three-group cross-section set is adequate for Cs-137 computations. Future work is aimed at implementing an optimized version of Attila for radiotherapy calculations.
authors.affiliation: Division of Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. kagifford@mdanderson.org
authors.forename: Kent A
authors.initials: KA
authors.lastname: Gifford
authors.forename: Todd A
authors.initials: TA
authors.lastname: Wareing
authors.forename: Gregory
authors.initials: G
authors.lastname: Failla
authors.forename: John L
authors.initials: JL
authors.lastname: Horton
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Eifel
authors.forename: Firas
authors.initials: F
authors.lastname: Mourtada
mesh_terms: D000465:Algorithms; D001918:Brachytherapy; D002588:Cesium Radioisotopes / Q000627:therapeutic use; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D009010:Monte Carlo Method; D053758:Nanoparticles; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D002588:Cesium Radioisotopes