Influence of orally administered bovine lactoferrin on lipid metabolism in lipopolysaccharide-injected preruminant calves.
ABSTRACT The aim of this study was to investigate the influence of oral lactoferrin (LF) administration on lipid metabolism changes in calves given lipopolysaccharide (LPS). Twenty-one 4-day-old Holstein calves were divided into three groups, with each group receiving one of three oral doses of LF (0, 1, 3 g/day) for 10 consecutive days (day -10 to day -1). All calves were intravenously injected with LPS (50 ng/kg BW) on day 0, the day after LF treatment ended. Plasma triglyceride concentrations were lower (P < 0.05) in the LF-treated calves than in the control calves given 0 g/day of LF at 12 and 24 h after LPS injection. Plasma NEFA concentrations were elevated between 6 and 24 h after LPS treatment. At 12 h, the concentration of plasma NEFA was lower (P < 0.05) in the calves given LF 3 g/day than in the control calves. On day 0, plasma total cholesterol and phospholipid concentrations tended to be lower in the LF groups administered 1 and 3 g of LF/day than in the control group, but did not differ significantly among the groups. The plasma very-low-density and low-density lipoprotein concentrations were lower (P < 0.05) at 12, 24, and 72 h in the LF groups than in the control calves. The concentrations of plasma high-density lipoprotein tended to be lower in the LF groups than in the control group between day 0 and 96 h, though there were no significant group differences. The concentration of plasma interleukin-1beta was lower (P < 0.05) in the calves fed LF 3 g/day than in the control calves at 2 and 12-48 h after LPS injection. These data suggest that LF inhibits LPS-induced alterations in lipid metabolism in preruminant calves.
Kushibiki
Shiro
S
Department of Animal Physiology and Nutrition, National Institute of Livestock and Grassland Science, Tsukuba, Japan. mendoza@affrc.go.jp
Shingu
Hiroyuki
H
Komatsu
Tokushi
T
Itoh
Fumiaki
F
Moriya
Naoko
N
Touno
Eiko
E
Oshibe
Akinori
A
Hodate
Koichi
K
D000284:Administration, Oral; D000818:Animals; D002417:Cattle / Q000378:metabolism*; D007781:Lactoferrin / Q000008:administration & dosage*; D050356:Lipid Metabolism / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000378:metabolism*
D008070:Lipopolysaccharides; D007781:Lactoferrin