title: Effects of botulinum toxin-a therapy for palmar hyperhidrosis in plantar sweat production.
abstract: BACKGROUND
  Patients with focal hyperhidrosis in multiple areas often report improvement of plantar hyperhidrosis after botulinum toxin A (BTX-A) therapy for palmar hyperhidrosis.
  
  
  OBJECTIVE
  To assess sweat production from the soles in patients receiving BTX-A treatment for their palmar hyperhidrosis.
  
  
  METHODS
  Thirty-six patients with both palmar and plantar hyperhidrosis received 100 U of BTX-A per palm. Sweat production of palms and soles was assessed using a starch iodine test and gravimetry at baseline and 1, 3, and 8 months after treatment. Patients were subjectively assessed using a percentile scale.
  
  
  RESULTS
  All patients had significant improvement in their palmar hyperhidrosis that lasted for 6.2 +/- 1.8 months. Gravimetry revealed marginal improvement of plantar hyperhidrosis in 12 patients (from 39.7 +/- 21.3 to 31.5 +/- 18.0 mg/min; p=.01) and statistically significant worsening in 24 patients (from 71.6 +/- 70.60 to 109.94 +/- 82.93 mg/min, p<.001).
  
  
  CONCLUSIONS
  Treatment of palmar hyperhidrosis with BTX-A increased plantar sweating in many patients affected by both palmar and plantar hyperhidrosis in the population under study. Regardless, patients reported satisfaction with the results and were willing to repeat treatment.
authors.affiliation: Hyperhidrosis Clinic, A Sygros Hospital, Athens, Greece.
authors.forename: Stamatis
authors.initials: S
authors.lastname: Gregoriou
authors.forename: Dimitris
authors.initials: D
authors.lastname: Rigopoulos
authors.forename: Michael
authors.initials: M
authors.lastname: Makris
authors.forename: Anastasia
authors.initials: A
authors.lastname: Liakou
authors.forename: Efi
authors.initials: E
authors.lastname: Agiosofitou
authors.forename: Christina
authors.initials: C
authors.lastname: Stefanaki
authors.forename: George
authors.initials: G
authors.lastname: Kontochristopoulos
mesh_terms: D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D005528:Foot; D006225:Hand; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy*; D009498:Neurotoxins / Q000627:therapeutic use; D017060:Patient Satisfaction; D013542:Sweat / Q000378:metabolism; D016896:Treatment Outcome
chemical_list: D009498:Neurotoxins; D019274:Botulinum Toxins, Type A