title: Enantioselective Host-Guest Complexation of Ru(II) trisdiimine complexes using neutral and anionic derivatized cyclodextrins.
abstract: Enantioselective host-guest complexation between five racemic Ru(II) trisdiimine complexes and eight derivatized cyclodextrins (CDs) has been examined by NMR techniques. The appearance of non-equivalent complexation-induced shifts of between the Δ and Λ-enantionomers of the Ru(II) trisdiimine complexes and derivatized CDs is readily observed by NMR. In particular, sulfobutyl ether-β-cyclodextrin sodium salt (SBE-β-CD), R-naphtylethyl carbamate β-cyclodextrin (RN-β-CD), and S-naphtylethyl carbamate β-cyclodextrin (SN-β-CD) showed good enantiodiscrimination for all five Ru complexes examined, which indicates that aromatic and anionic derivatizing groups are beneficial for chiral recognition. The complexation stoichiometry between SBE-β-CD and [Ru(phen)(3)](2+) was found to be 1: 1 and binding constants reveal that Λ-[Ru(phen)(3)](2+) binds more strongly to SBE-β-CD than the Δ-enantiomer. Correlations between this NMR method and separative techniques based on CDs as chiral discriminating agents (i.e., selectors) are discussed in detail.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas at Arlington, TX 76019, USA.
authors.forename: Ping
authors.initials: P
authors.lastname: Sun
authors.forename: Frederick M
authors.initials: FM
authors.lastname: Macdonnell
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Armstrong