Cellular sources of tissue factor in endotoxemia and sepsis.
Sepsis is a systemic host response to infection by pathogenic microorganisms. Activation of the coagulation cascade during endotoxemia and sepsis leads to disseminated intravascular coagulation. This review focuses on tissue factor expression by hematopoietic and non-hematopoietic cells and its contribution to the activation of coagulation during endotoxemia and sepsis.
Pawlinski
Rafal
R
Hematology and Oncology Division, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27516, USA.
Mackman
Nigel
N
D000818:Animals; D000991:Antithrombins / Q000737:chemistry; D001777:Blood Coagulation; D042783:Endothelial Cells / Q000737:chemistry; D019446:Endotoxemia / Q000378:metabolism*; D006410:Hematopoiesis; D006801:Humans; D008070:Lipopolysaccharides / Q000737:chemistry; D008954:Models, Biological; D018805:Sepsis / Q000378:metabolism*; D013917:Thrombin / Q000737:chemistry; D013925:Thromboplastin / Q000378:metabolism*
D000991:Antithrombins; D008070:Lipopolysaccharides; D013925:Thromboplastin; D013917:Thrombin