Modulating tumor vasculature through signaling inhibition to improve cytotoxic therapy.
The tumor microenvironment is a key factor in cancer treatment response. Recent work has shown that changes in the tumor vasculature can be achieved by inhibiting tumor cell signaling, resulting in enhanced tumor oxygenation. These changes could promote responses to both chemo- and radiation therapy.
Maity
Amit
A
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Bernhard
Eric J
EJ
D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000628:therapy; D010100:Oxygen / Q000378:metabolism; D015398:Signal Transduction
D010100:Oxygen