title: Pulmonary carcinosarcoma initially presenting as invasive aspergillosis: a case report of previously unreported combination.
abstract: Carcinosarcoma of the lung is a malignant tumor composed of a mixture of carcinoma and sarcoma elements. The carcinomatous component is most commonly squamous followed by adenocarcinoma. The sarcomatous component commonly comprises the bulk of the tumor and shows poorly differentiated spindle cell features. Foci of differentiated sarcomatous elements such as chondrosarcoma and osteosarcoma may be seen. Aspergillus pneumonia is the most common form of invasive aspergillosis and occurs mainly in patients with malignancy, immunocompromising or debilitating diseases. Patients with Aspergillus pneumonia present with fever, cough, chest pain and occasionally hemoptysis. Tissue examination is the most reliable method for diagnosis, and mortality rate is high.We describe a case of primary carcinosarcoma of the lung concurrently occurring with invasive pulmonary aspergillosis in a 66-year old patient.
authors.affiliation: Department of Medicine, Sinai Grace Hospital/Detroit Medical Center, Detroit, Michigan, USA. olobatoke@yahoo.com
authors.forename: Ariyo O
authors.initials: AO
authors.lastname: Olobatoke
authors.forename: Doina
authors.initials: D
authors.lastname: David
authors.forename: Wasif
authors.initials: W
authors.lastname: Hafeez
authors.forename: Thien
authors.initials: T
authors.lastname: Van
authors.forename: Husain A
authors.initials: HA
authors.lastname: Saleh
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001230:Aspergillus / Q000302:isolation & purification; D044963:Biopsy, Fine-Needle; D002296:Carcinosarcoma / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D055744:Invasive Pulmonary Aspergillosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D011013:Pneumonectomy; D011014:Pneumonia / Q000382:microbiology; D013908:Thoracotomy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents