Tau kinase I overexpression induces dentate gyrus degeneration.
Familial Alzheimer gene mutations result in a signaling mechanism that converges, downstream, in the activation of GSK3 activity. We have generated a GSK3 transgenic mouse model to study the consequences of GSK3 activation. In this model, dentate gyrus is degenerated in a process in which phosphorylated tau can be involved.
Avila
Jesús
J
Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Madrid, Spain. javila@cbm.uam.es
Gómez de Barreda
Elena
E
Engel
Tobias
T
Pérez
Mar
M
Martín-Maestro
Patricia
P
Fuster-Matanzo
Almudena
A
Goñi-Oliver
Paloma
P
Lucas
José J
JJ
Hernández
Félix
F
D000818:Animals; D018891:Dentate Gyrus / Q000201:enzymology* / Q000473:pathology; D004195:Disease Models, Animal; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics*; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D019636:Neurodegenerative Diseases / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism
C054369:MAPT protein, human; D016875:tau Proteins; D038362:Glycogen Synthase Kinase 3