title: The velo-cardio-facial syndrome: the spectrum of psychiatric problems and cognitive deterioration at adult age.
abstract: The velo-cardio-facial syndrome: the spectrum of psychiatric problems and cognitive deterioration at adult age: Deletion 22q11.2 syndrome, or the velo-cardio-facial syndrome (VCFS), is a syndrome with a known but varied clinical and behavioral phenotype. We report 7 patients with 22q11.2 deletion syndrome and an intellectual disability. Aside from the described behavioral phenotype in literature, a moderate, severe or profound intellectual disability may be present. Special attention should be given to cognitive deterioration.
authors.affiliation: Koraal Group, MFCG, Multi-Disciplinary Centre for Dual Disabilities, Heel, The Netherlands. revers@stanna.koraalgroep.nl
authors.forename: L J M
authors.initials: LJ
authors.lastname: Evers
authors.forename: C E M
authors.initials: CE
authors.lastname: De Die-Smulders
authors.forename: E E J
authors.initials: EE
authors.lastname: Smeets
authors.forename: M G M
authors.initials: MG
authors.lastname: Clerkx
authors.forename: L M G
authors.initials: LM
authors.lastname: Curfs
mesh_terms: D000328:Adult; D001321:Autistic Disorder / Q000209:etiology; D003704:Dementia / Q000209:etiology; D004062:DiGeorge Syndrome / Q000523:psychology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000209:etiology*; D007360:Intelligence; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D019965:Neurocognitive Disorders / Q000209:etiology*; D011618:Psychotic Disorders / Q000209:etiology*; D012559:Schizophrenia / Q000209:etiology