A convergent approach for the synthesis of ara-neplanocin a analogues under subzero microwave assisted conditions.
A convergent strategy for the synthesis of ara-neplanocin A analogues has been developed. Microwave assisted Mitsunobu reaction proved to be an essential tool both for the 2'-beta-hydroxy inversion and for the coupling reaction with the heterocyclic bases. The exploitation of the present approach allowed generating a family of ara-neplanocins which biological potential is still unexplored.
Radi
Marco
M
College of Pharmacy, The University of Georgia, Athens, Georgia, USA.
Rao
Jagadeeshwar R
JR
Jha
Ashok K
AK
Chu
Chung K
CK
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry*; D008872:Microwaves
D000998:Antiviral Agents; C031096:neplanocin A; D000241:Adenosine