Metals make proteins stick.
Salgado et al. (2009b) report the rational design of protein interfaces based on metal-mediated association. Initially coordinated via zinc, the adapted interface self-associates, even in the absence of metal. The approach is hypothesized to mimic the early evolution of protein assemblies.
Höcker
Birte
B
Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany. birte.hoecker@tuebingen.mpg.de