title: Recent advances in understanding the molecular mechanisms regulating C. elegans transcription.
abstract: We review recent studies that have advanced our understanding of the molecular mechanisms regulating transcription in the nematode C. elegans. Topics covered include: (i) general properties of C. elegans promoters; (ii) transcription factors and transcription factor combinations involved in cell fate specification and cell differentiation; (iii) new roles for general transcription factors; (iv) nucleosome positioning in C. elegans "chromatin"; and (v) some characteristics of histone variants and histone modifications and their possible roles in controlling C. elegans transcription.
authors.affiliation: Department of Biochemistry and Molecular Biology, Alberta Children's Hospital Research Institute for Child and Maternal Health, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Jeb
authors.initials: J
authors.lastname: Gaudet
authors.forename: James D
authors.initials: JD
authors.lastname: McGhee
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D019070:Cell Lineage / Q000235:genetics; D005786:Gene Expression Regulation; D011401:Promoter Regions, Genetic; D014157:Transcription Factors; D014158:Transcription, Genetic
chemical_list: D014157:Transcription Factors