Application of mixture experimental design in the formulation and optimization of matrix tablets containing carbomer and hydroxy-propylmethylcellulose.
Using mixture experimental design, the effect of carbomer (Carbopol((R)) 971P NF) and hydroxypropylmethylcellulose (Methocel((R)) K100M or Methocel((R)) K4M) combination on the release profile and on the mechanism of drug liberation from matrix tablet was investigated. The numerical optimization procedure was also applied to establish and obtain formulation with desired drug release. The amount of TP released, release rate and mechanism varied with carbomer ratio in total matrix and HPMC viscosity. Increasing carbomer fractions led to a decrease in drug release. Anomalous diffusion was found in all matrices containing carbomer, while Case - II transport was predominant for tablet based on HPMC only. The predicted and obtained profiles for optimized formulations showed similarity. Those results indicate that Simplex Lattice Mixture experimental design and numerical optimization procedure can be applied during development to obtain sustained release matrix formulation with desired release profile.
Petrovic
Aleksandra
A
Galenika a.d., Institute for Research and Development, Batajnicki drum b.b, Belgrade, Serbia.
Cvetkovic
Nebojsa
N
Ibric
Svetlana
S
Trajkovic
Svetlana
S
Djuric
Zorica
Z
Popadic
Dragica
D
Popovic
Radmila
R
D000179:Acrylates / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations; D015195:Drug Design; D005079:Excipients / Q000737:chemistry*; D065347:Hypromellose Derivatives; D007700:Kinetics; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets / Q000737:chemistry*; D013806:Theophylline / Q000737:chemistry / Q000302:isolation & purification
D000179:Acrylates; D003692:Delayed-Action Preparations; D005079:Excipients; D013607:Tablets; C492577:carbopol 971P; D065347:Hypromellose Derivatives; D008747:Methylcellulose; D013806:Theophylline