[Advances in genome-wide association study of coronary heart disease].
As a new effective strategy for researching complex diseases, genome-wide association study (GWAS) has being developed rapidly in recent years worldwide. The world genomic study has been taken into a new stage, since a series of disease related genes or variants have been identified by GWAS strategy. Coronary heart disease (CHD) is a complex disease that is caused by both environmental and genetic factors, and has become one of the leading causes of death and disability worldwide. With the application of GWAS strategy, researchers from all over the world have identified many susceptibility loci or regions of CHD that were unable to be identified by candidate gene case-control study. The present paper reviewed the important progresses worldwide attained in GWAS of CHD in recent years. Then it is also expounded the challenges we are facing nowadays in GWAS as well as the future study direction. The information outlined in this paper provides us a valuable guidance upon further exploration into genetic mechanism of CHD.
Yang
Ying
Y
Department of Population Genetics and Prevention, Fu Wai Hospital alt; Cardiovascular Institute, Peking Union Medical College alt; Chinese Academy of Medical Sciences, Beijing 100037, China. yangying0605.student@sina.com
Lu
Xiang-Feng
XF
D003327:Coronary Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005826:Genetics, Medical; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide