title: Pd(II)-catalyzed olefination of sp3 C-H bonds.
abstract: The first Pd(II)-catalyzed sp(3) C-H olefination reaction has been developed using N-arylamide directing groups. Following olefination, the resulting intermediates were found to undergo rapid 1,4-addition to give the corresponding gamma-lactams. Notably, this method was effective with substrates containing alpha-hydrogen atoms and could be applied to effect methylene C-H olefination of cyclopropane substrates.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
authors.forename: Masayuki
authors.initials: M
authors.lastname: Wasa
authors.forename: Keary M
authors.initials: KM
authors.lastname: Engle
authors.forename: Jin-Quan
authors.initials: JQ
authors.lastname: Yu
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D006859:Hydrogen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D010165:Palladium; D002244:Carbon; D006859:Hydrogen