title: Management of acute exacerbations in multiple sclerosis.
abstract: A key component of multiple sclerosis is the occurrence of episodes of clinical worsening with either new symptoms or an increase in older symptoms over a few days or weeks. These are known as exacerbations of multiple sclerosis. In this review, we summarize the pathophysiology and treatment of exacerbations and describe how they are related to the overall management of this disease.
authors.affiliation: Neurological Institute, Cleveland Clinic, Cleveland, Ohio, 44195 USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Ontaneda
authors.forename: Alex D
authors.initials: AD
authors.lastname: Rae-Grant