title: A phantom for investigation of tumour signal and noise in PET reconstruction with various smoothing filters: experiments and comparisons with simulated intensity diffusion.
abstract: An abdomen phantom, containing an idealised fillable liver volume was developed. A fast settling gel was used to produce a row of simulated tumours as well as normal surrounding tissue, each of these components containing different concentrations of (18)F-FDG. The magnitude of the signal above normal tissue intensity as well as the noise was obtained after reconstructions with Ordered Subset expectation-maximization (OSEM) and various Gaussian smoothing filters. Signals derived by 'simulated intensity diffusion' agreed well with experimental results.
authors.affiliation: The Interventional Centre, Oslo University Hospital, Oslo. arne.skretting@radiumhospitalet.no
authors.forename: A
authors.initials: A
authors.lastname: Skretting
authors.forename: O
authors.initials: O
authors.lastname: Glomset
authors.forename: T V
authors.initials: TV
authors.lastname: Bogsrud
mesh_terms: D000465:Algorithms; D004305:Dose-Response Relationship, Drug; D019788:Fluorodeoxyglucose F18 / Q000008:administration & dosage; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods*; D019275:Radiopharmaceuticals / Q000008:administration & dosage; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012815:Signal Processing, Computer-Assisted
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18