title: Restoration of peri-implant defects in immediate implant installations by Choukroun platelet-rich fibrin and silk fibroin powder combination graft.
abstract: OBJECTIVE
  The objective of this study was to determine the capability of silk fibroin powder as a biomaterial template for the restoration of peri-implant defects when mixed with Choukroun platelet-rich fibrin (PRF) in vivo.
  
  
  METHODS
  Ten New Zealand white rabbits were used for this study. Using a trephine bur (diameter 7.0 mm), 2 monocortical defects were prepared. Subsequently, 2 dental implants were installed into the tibia (diameter 3.0 mm, length 10.0 mm). In the experimental group, the peri-implant defect was filled with a combination graft of silk fibroin powder and Choukroun PRF. The control was left in an unfilled state. The animals were killed at 8 weeks. Subsequently, a removal torque test and a histomorphometric analysis were done.
  
  
  RESULTS
  The removal torque for the experimental group was 30.34 +/- 5.06 N.cm, whereas it was 21.86 +/- 3.39 N.cm for the control. The difference between the 2 groups was statistically significant (P = .010). Mean new bone formation was 51.93 +/- 27.90% in the experimental group and 11.67 +/- 15.12% in the control (P = .003). Mean bone-to-implant contact was 43.07 +/- 21.96% in the experimental group and 15.37 +/- 23.84% in the control (P = .002).
  
  
  CONCLUSIONS
  A peri-implant defect can be successfully repaired by the application of Choukroun PRF and silk fibroin powder.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Hallym University, Kyoungkido, Korea.
authors.forename: Eun-Sik
authors.initials: ES
authors.lastname: Jang
authors.forename: Jun-Woo
authors.initials: JW
authors.lastname: Park
authors.forename: Haeyong
authors.initials: H
authors.lastname: Kweon
authors.forename: Kwang-Gill
authors.initials: KG
authors.lastname: Lee
authors.forename: Seok-Woo
authors.initials: SW
authors.lastname: Kang
authors.forename: Dong-Heon
authors.initials: DH
authors.lastname: Baek
authors.forename: Je-Yong
authors.initials: JY
authors.lastname: Choi
authors.forename: Seong-Gon
authors.initials: SG
authors.lastname: Kim
mesh_terms: D016301:Alveolar Bone Loss / Q000628:therapy*; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D001684:Biological Dressings; D012831:Bombyx; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes / Q000627:therapeutic use; D003758:Dental Implantation, Endosseous / Q000379:methods*; D015921:Dental Implants; D020878:Device Removal; D004195:Disease Models, Animal; D004338:Drug Combinations; D005337:Fibrin / Q000627:therapeutic use*; D005349:Fibroins / Q000627:therapeutic use*; D019476:Insect Proteins / Q000627:therapeutic use; D016348:Osseointegration / Q000187:drug effects; D053657:Platelet-Rich Plasma; D011817:Rabbits; D047011:Silk; D054457:Tissue Scaffolds; D019415:Torque
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D015921:Dental Implants; D004338:Drug Combinations; D019476:Insect Proteins; D047011:Silk; D005337:Fibrin; D005349:Fibroins