title: Diagnostic usefulness of endobronchial ultrasound-guided transbronchial needle aspiration in a case with malignant pleural mesothelioma.
abstract: A 74-year old man was admitted to our hospital with right diffuse pleural thickening and effusion and with subcarinal lymph node swelling. The effusion obtained by thoracentesis showed no malignant cells, although positron emission tomography showed abnormal uptake in the right pleural thickening and subcarinal lymph node. Histopathological examination of the lymph node specimens obtained by endobronchial ultrasound-guided transbronchial needle aspiration showed a sheet of epithelioid-like large atypical cells. The tumor cells were immunohistochemically positive for calretinin and cytokeratin 5/6, and negative for CEA and TTF-1. Therefore, malignant pleural mesothelioma of epithelioid type was diagnosed.
authors.affiliation: Department of Respiratory Medicine, Kumamoto University Hospital, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University. hamamoto-jun@umin.ac.jp
authors.forename: Junji
authors.initials: J
authors.lastname: Hamamoto
authors.forename: Daisuke
authors.initials: D
authors.lastname: Notsute
authors.forename: Kentaro
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Jiichiro
authors.initials: J
authors.lastname: Sasaki
authors.forename: Keisuke
authors.initials: K
authors.lastname: Kojima
authors.forename: Sho
authors.initials: S
authors.lastname: Saeki
authors.forename: Reina
authors.initials: R
authors.lastname: Tanaka
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Kohrogi
mesh_terms: D000368:Aged; D044963:Biopsy, Fine-Needle / Q000379:methods*; D064032:Calbindin 2; D006801:Humans; D053555:Keratin-5 / Q000378:metabolism; D053553:Keratin-6 / Q000378:metabolism; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008297:Male; D008654:Mesothelioma / Q000378:metabolism / Q000473:pathology*; D010997:Pleural Neoplasms / Q000378:metabolism / Q000473:pathology*; D049268:Positron-Emission Tomography; D064030:S100 Calcium Binding Protein G / Q000378:metabolism; D014463:Ultrasonography
chemical_list: C576764:CALB2 protein, human; D064032:Calbindin 2; D053555:Keratin-5; D053553:Keratin-6; D064030:S100 Calcium Binding Protein G