Distinguishing the viability of a single yeast cell with an ultra-sensitive radio frequency sensor.
We propose and demonstrate a simple, ultra sensitive radio frequency (RF) sensor to detect a single yeast cell and distinguish its viability in a microfluidic channel. On-chip interference is used to cancel background probing signals to improve sensor sensitivity. Individual viable and nonviable yeast cells (approximately 5.83 +/- 0.85 microm in diameter) are measured with clear sensing and identification of these cells.
Yang
Yang
Y
Department of Electrical and Computer Engineering, Clemson University, Clemson, South Carolina 29634, USA. yang6@clemson.edu
Zhang
Hanqiao
H
Zhu
Junjie
J
Wang
Gaoyan
G
Tzeng
Tzuen-Rong
TR
Xuan
Xiangchun
X
Huang
Kama
K
Wang
Pingshan
P
D015374:Biosensing Techniques / Q000295:instrumentation*; D002470:Cell Survival / Q000502:physiology* / Q000528:radiation effects; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005434:Flow Cytometry / Q000295:instrumentation*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D011846:Radio Waves; D015203:Reproducibility of Results; D012441:Saccharomyces cerevisiae / Q000502:physiology* / Q000528:radiation effects; D012680:Sensitivity and Specificity