title: How activity of inflammatory bowel disease influences bone loss.
abstract: Bone loss is a common problem for individuals with inflammatory bowel disease (IBD). The aim of our study was to assess bone mineral density (BMD) in patients with IBD and to investigate the role of corticosteroid (CS) use and duration and activity of disease on BMD. Ninety-two patients (56 men and 36 women) with IBD, of whom 32 had ulcerative colitis (UC) and 60 had Crohn's disease (CD), underwent clinical assessment. Lumbar and femoral neck BMDs were measured by dual-energy X-ray absorptiometry. Osteopenia was observed in 14 patients (43%) with UC and in 24 patients (40%) with CD (p=0.187). Four patients (12%) with UC and 7 patients (11%) with CD had osteoporosis (p=0.308). Femoral BMD decreased in patients with long duration of CS use and correlated inversely with disease activity. Multiple regression analysis of BMD showed that statistically significant risk factors were duration of active disease and body mass index as well. Based on our results, it is necessary to take into account the risk of decreased BMD in patients with IBD. It is most important to achieve disease remission as soon as possible in addition to nutritional support.
authors.affiliation: Department of Endocrinology, Diabetes and Metabolic Diseases, Clinical Hospital Centre Rijeka, Rijeka, Croatia. Electronic address: zeljka.crncevic@ri.t-com.hr.
authors.forename: Zeljka Crncevic
authors.initials: ZC
authors.lastname: Orlic
authors.affiliation: Department of Endocrinology, Diabetes and Metabolic Diseases, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
authors.forename: Tamara
authors.initials: T
authors.lastname: Turk
authors.affiliation: Department of Gastroenterology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
authors.forename: Brankica Mijandrusic
authors.initials: BM
authors.lastname: Sincic
authors.affiliation: Department of Gastroenterology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
authors.forename: Davor
authors.initials: D
authors.lastname: Stimac
authors.affiliation: Department of Anatomy, Medical School, University of Rijeka, Rijeka, Croatia.
authors.forename: Olga
authors.initials: O
authors.lastname: Cvijanovic
authors.affiliation: Department of Anatomy, Medical School, University of Rijeka, Rijeka, Croatia.
authors.forename: Ivana
authors.initials: I
authors.lastname: Maric
authors.affiliation: Department of Physiology and Immunology, University of Rijeka, Rijeka, Croatia.
authors.forename: Maja Ilic
authors.initials: MI
authors.lastname: Tomas
authors.affiliation: Department of Endocrinology, Diabetes and Metabolic Diseases, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
authors.forename: Dubravka
authors.initials: D
authors.lastname: Jurisic-Erzen
authors.affiliation: Department of Gastroenterology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
authors.forename: Vanja
authors.initials: V
authors.lastname: Licul
authors.affiliation: Department of Anatomy, Medical School, University of Rijeka, Rijeka, Croatia.
authors.forename: Dragica
authors.initials: D
authors.lastname: Bobinac
mesh_terms: D015502:Absorptiometry, Photon / Q000379:methods*; D000328:Adult; D000368:Aged; D015519:Bone Density; D001862:Bone Resorption / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000378:metabolism; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors; D055815:Young Adult