title: Alterations in the immunoexpression of claudin-1 between different grades of oral epithelial dysplasias.
abstract: Claudins are transmembrane proteins that play a role in cell proliferation and adhesion and tumourigenesis. This study evaluated the immunoexpression of claudin-1 in the oral epithelial dysplasia (OED) (19 mild, 26 moderate, 3 severe). Diffuse staining predominated in mild (89.4%) and moderate (80.8%) OEDs. Immunoexpression in the middle and upper third was observed in all mild cases, whereas in moderate/severe dysplasias staining was observed in the upper third in 41.4% of cases, in the upper and middle third in 41.4%, and in the upper, middle and lower third in 17.2% (P<0.05). All mild OEDs and 73.1% of moderate cases presented only membrane staining, whereas membrane/cytoplasmic staining was observed in severe cases. Staining intensity was weak in 60% of parakeratinized OEDs and moderate/strong in orthokeratinized OEDs (60.8%) (P>0.05). The differences in the immunoexpression of claudin-1 between different grades of OEDs suggest the involvement of this protein in the progression of dysplasias.
authors.affiliation: Post-Graduate Program, Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Marianne de Vasconcelos
authors.initials: Mde V
authors.lastname: Carvalho
authors.forename: Joabe Dos Santos
authors.initials: Jdos S
authors.lastname: Pereira
authors.forename: Antonio de Lisboa Lopes
authors.initials: Ade L
authors.lastname: Costa
authors.forename: Lélia Batista
authors.initials: LB
authors.lastname: de Souza
authors.forename: Roseana de Almeida
authors.initials: Rde A
authors.lastname: Freitas
authors.forename: Márcia Cristina da Costa
authors.initials: MC
authors.lastname: Miguel
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D016009:Chi-Square Distribution; D062445:Claudin-1; D006801:Humans; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000378:metabolism*; D009061:Mouth Mucosa / Q000378:metabolism* / Q000473:pathology*; D011230:Precancerous Conditions / Q000378:metabolism* / Q000473:pathology*; D013194:Staining and Labeling
chemical_list: D014408:Biomarkers, Tumor; C568108:CLDN1 protein, human; D062445:Claudin-1; D008565:Membrane Proteins