title: Double selective synthetic approach to the N-functionalized 1,4,7-triazacyclononane derivatives: chelating compounds for controllable protein orientation.
abstract: The double selective synthetic approach is proposed for easy preparation of asymmetrically N-substituted derivatives of 1,4,7-triazacyclononane (tacn, [9]aneN(3)) with the same or different pendant arms. The synthetic routes simplify the synthesis of "tacn" ligands for functionalization of other carboxy terminated molecules/supports and also facilitate access to azamacrocycle functionalized self-assembled monolayer (SAMs) or nanopatterns for specific and stable Histidine-tagged protein immobilization.
authors.affiliation: Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw 02-106, Poland. tomasz_s@ibb.waw.pl
authors.forename: Tomasz D
authors.initials: TD
authors.lastname: Sobieściak
authors.forename: Piotr
authors.initials: P
authors.lastname: Zielenkiewicz
mesh_terms: D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D004800:Enzymes, Immobilized; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008024:Ligands; D015394:Molecular Structure; D011485:Protein Binding; D011506:Proteins / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D002614:Chelating Agents; D004800:Enzymes, Immobilized; D006571:Heterocyclic Compounds; D008024:Ligands; D011506:Proteins; C075712:1,4,7-triazacyclononane