Blood Pressure and Left Ventricular Characteristics in Young Patients with Classical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency.
High steroid doses are often necessary in congenital adrenal hyperplasia (CAH) to suppress androgens and may increase blood pressure (BP). We evaluated 24-hour BP profile (ambBP), BP during exercise (excBP), and echocardiography in 20 young CAH patients. Systolic and diastolic BP during ambBP and excBP was normal in all patients. None presented myocardial hypertrophy. Nocturnal diastolic BP was affected by testosterone (P: .016, 95% CI: 0.002 to 0.021, beta = 0.01). Left ventricular mass (LVM ) was affected by height SDS (P: .007, 95% CI: 2.67 to 14.17, beta = 8.42), age (P: < .0001, 95% CI: 2.12 to 5.82, beta = 3.97), and testosterone (P: .008, 95% CI: 0.01 to 0.09, beta = 0.053). Left ventricular mass index (LVMI) correlated with BMI SDS (P: .044, 95% CI: 0.09 to 6.17, beta = 3.13) and testosterone (P: .031, 95% CI: 0.002 to 0.035, beta = 0.018). Hydrocortisone dose did not influence ambBP, excBP, or myocardial hypertrophy.
Ubertini
Graziamaria
G
Department of Pediatrics, Unit of Endocrinology and Diabetes, Bambino Gesù Children's Hospital, School of Medicine, University of Rome Tor Vergata, P.zza S. Onofrio 4, 00165 Rome, Italy.
Bizzarri
Carla
C
Grossi
Armando
A
Gimigliano
Fabrizio
F
Ravà
Lucilla
L
Fintini
Danilo
D
Cappa
Marco
M