Molecular regulation of Nogo-A in neural cells: Novel insights into structure and function.
Nogo-A is part of the reticulon family of proteins localized to the myelin and oligodendroglial plasma membranes. Nogo-A specifically initiates signal transduction cascades limiting axonal regrowth following injury and disease in the adult mammalian central nervous system (CNS). Recent novel data support the contention that neuronal Nogo-A plays an important role in regulating cytoskeletal re-organization without the requirement of signaling through its cognate receptor (Nogo receptor). These data, along with the recent findings that the N-terminus of Nogo-A can interact with integrins and that NgR1 interacts with the amyloid precursor protein extracellularly, as well as novel findings showing ubiquitin ligases binding with Nogo-A intracellularly add a layer of complexity to its functional role in the CNS.
Bongiorno
Daria
D
Health Innovations Research Institute, Royal Melbourne Institute of Technology University, Bundoora, Victoria 3083, Australia.
Petratos
Steven
S
D000818:Animals; D006801:Humans; D009185:Myelin Proteins / Q000737:chemistry* / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D000070798:Nogo Proteins
D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603199:RTN4 protein, human