Synthesis of novel 5'-uridine-head amphiphiles as model for DNA molecular recognition.
Here we describe uridine functionalization in the 5' position, which provides new classes of cationic and nonionic amphiphiles specifically designed as DNA transfection agents. The synthetic procedures developed to obtain the cationic uridine-head surfactants prevented intramolecular cyclization that occurs when uridine is functionalized in this position without using protecting groups in the uracil.
Tiecco
Matteo
M
CEMIN-Excellence Centre on Innovative Nanostructured Materials, Department of Chemistry, University of Perugia, Perugia, Italy.
Di Profio
Pietro
P
Germani
Raimondo
R
Savelli
Gianfranco
G
D003500:Cyclization; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D014162:Transfection; D014529:Uridine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry*
D013501:Surface-Active Agents; D004247:DNA; D014529:Uridine