The unabated synthesis of new nucleoside analogues with antiviral potential: a tribute to Morris J. Robins.
The furo[2,3-d]pyrimidin-2(3H)-one is the key structural determinant in the exquisitely potent activity of its derivatives (R = 2-deoxyribosyl; R' = p-pentylphenyl) against VZV (varicella-zoster virus) replication. [structure: see text].
De Clercq
Erik
E
Rega Institute for Medical Research, K.U. Leuven, Leuven, Belgium. erik.declercq@rega.kuleuven.be
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014777:Virus Diseases / Q000188:drug therapy; D014780:Viruses / Q000187:drug effects
D000998:Antiviral Agents; D011741:Pyrimidine Nucleosides