Investigation of biokinetics of radioiodine with a population kinetics approach.
The dosimetric studies required for planning individually tailored radioiodine therapy of benign thyroid pathologies may be too complex and time-demanding for many ordinary nuclear medicine departments. In this work, a preliminary population kinetics approach was applied to a model structure for iodine biokinetics in order to identify those model features that actually need to be individually investigated, in order to simplify the protocol for data collection in patients. Data from 29 patients undergoing radioiodine therapy for the treatment of the autonomous nodule syndrome were used in the analysis. The greatest inter-individual variations were observed in the parameters describing the transformation of iodide into organic iodine in the thyroid and in the kinetics of the organic form.
Janzen
T
T
Institute of Radiation Protection, Helmholtz Zentrum München, Ingolstädter Landstr 1, 85764 Neuherberg, Germany. tilman.janzen@helmholtz-muenchen.de
Giussani
A
A
Canzi
C
C
Gerundini
P
P
Oeh
U
U
Hoeschen
C
C
D003198:Computer Simulation; D006801:Humans; D006980:Hyperthyroidism / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000532:radiotherapy*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D007700:Kinetics; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics / Q000627:therapeutic use; D014018:Tissue Distribution
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals