External auditory canal and middle ear relapse of acute promyelocytic leukemia treated with arsenic trioxide: case report and review of the literature.
Extramedullary involvement occurs infrequently in acute promyelocytic leukemia and is said to be more common after treatment with all-trans retinoic acid. We describe a 9-year-old girl who had an isolated external auditory canal and middle ear relapse after treatment with all-trans retinoic acid and chemotherapy. A patient with cytogenetically and molecularly confirmed acute promyelocytic leukemia developed isolated extramedullary relapse in the auditory canal and middle ear 4 years and 9 months after initial diagnosis, while in hematologic and molecular remission, successfully treated with arsenic trioxide alone.
Lafayette
Thereza Christina Sampaio
TC
Department of Pediatric Hematology-Oncology, Universidade Federal de Santa Maria, Rio Grande do Sul, Brazil. tcslaf@terra.com.br
Coser
Virginia Maria
VM
Brûlé
Alice Odette
AO
Coser
Pedro Luis
PL
Pereira
Waldir Veiga
WV
D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000627:therapeutic use*; D002648:Child; D004424:Ear Canal / Q000187:drug effects / Q000473:pathology*; D004428:Ear Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D004432:Ear, Middle / Q000187:drug effects / Q000473:pathology*; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000175:diagnosis* / Q000188:drug therapy; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D010087:Oxides / Q000627:therapeutic use*; D016896:Treatment Outcome
D001152:Arsenicals; D010087:Oxides; D000077237:Arsenic Trioxide