title: Colorectal cancer complicating inflammatory bowel disease: a comparative study of Crohn's disease vs ulcerative colitis in 34 patients.
abstract: OBJECTIVE
  Colorectal cancer (CRC) complicating inflammatory bowel disease (IBD) accounts for 10-15% of all IBD deaths. Survival of patients with IBD-related CRC was reviewed to analyse differences between ulcerative colitis (UC) and Crohn's disease (CD).
  
  
  METHODS
  We analysed (24 men and 10 women) patients with CD (n = 14) or UC (n = 20) with CRC, who presented between 1990 and 2007, and were followed to October, 2009.
  
  
  RESULTS
  The mean age of patients was 56 ± 12 years for patients with UC and 49 ± 17 years for patients with CD, and the mean duration of symptoms was 22 ± 11 and 16 ± 8 years, respectively. The median duration of follow up after the diagnosis of CRC was 49 (1-157) months. Recurrence occurred in five patients with UC and in nine with CD (P = 0.02). The overall and disease free five year survivals were significantly higher in patients with UC than CD [70%vs 43% (P = 0.01) and 63%vs 31% (P = 0.01), respectively].
  
  
  CONCLUSIONS
  The results showed a poorer prognosis of CRC in patients with CD than with UC.
authors.affiliation: Department of Colorectal Surgery, PMAD, Beaujon Hospital, AP-HP, Clichy, France.
authors.forename: M
authors.initials: M
authors.lastname: Ouaïssi
authors.forename: L
authors.initials: L
authors.lastname: Maggiori
authors.forename: A
authors.initials: A
authors.lastname: Alves
authors.forename: U
authors.initials: U
authors.lastname: Giger
authors.forename: I
authors.initials: I
authors.lastname: Sielezneff
authors.forename: P
authors.initials: P
authors.lastname: Valleur
authors.forename: B
authors.initials: B
authors.lastname: Sastre
authors.forename: Y
authors.initials: Y
authors.lastname: Panis
mesh_terms: D000328:Adult; D000368:Aged; D017024:Chemotherapy, Adjuvant; D003093:Colitis, Ulcerative / Q000150:complications* / Q000401:mortality / Q000473:pathology; D015179:Colorectal Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology / Q000601:surgery; D003424:Crohn Disease / Q000150:complications* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D015996:Survival Rate