Apoptosis inducing activity of steroidal constituents from Solanum xanthocarpum and Asparagus racemosus.
A series of Sarsapogenin and Diosgenin derived steroidal constituents (1-12), isolated from Solanum xanthocarpum and Asparagus racemosus were screened for their ability to induce cell death and apoptosis of colon carcinoma cells. The carbohydrate moieties linked to the steroid backbones were found to strongly influence cytotoxic activity and cell death mode (apoptosis or necrosis). Compound 10, from A. racemosus was found to be a potent inducer of apoptosis.
Bhutani
K K
KK
Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Mohali-160062, Punjab, India. kkbhutani@niper.ac.in
Paul
A T
AT
Fayad
W
W
Linder
S
S
D017209:Apoptosis; D027761:Asparagus Plant / Q000737:chemistry*; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D032322:Solanum / Q000737:chemistry*; D013256:Steroids / Q000302:isolation & purification / Q000494:pharmacology*
D013256:Steroids