title: Asphorodin, a potent lipoxygenase inhibitory triterpene diglycoside from Asphodelus tenuifolius.
abstract: Asphorodin (1), a new diglycoside, has been isolated from the ethyl acetate-soluble fraction of Asphodelus tenuifolius. It showed significant inhibitory activity against the enzyme lipoxygenase in a concentration-dependent manner. The Lineweaver-Burk and Dixon plots indicated that the nature of inhibition was non-competitive.
authors.affiliation: International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.
authors.forename: Muhammad
authors.initials: M
authors.lastname: Safder
authors.forename: Muhammad
authors.initials: M
authors.lastname: Imran
authors.forename: Rashad
authors.initials: R
authors.lastname: Mehmood
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Nighat
authors.initials: N
authors.lastname: Afza
authors.forename: Lubna
authors.initials: L
authors.lastname: Iqbal
authors.forename: Mehreen
authors.initials: M
authors.lastname: Latif
mesh_terms: D004305:Dose-Response Relationship, Drug; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019668:Liliaceae / Q000737:chemistry*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D010154:Pakistan; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D006027:Glycosides; D016859:Lipoxygenase Inhibitors; D014315:Triterpenes; C547977:asphorodin