title: CD8CD11a(high) cells decreased in multiple sclerosis but not in neuromyelitis Optica.
abstract: In order to clarify the immunological characteristics of multiple sclerosis (MS) and neuromyelitis optica (NMO), we analyzed CD3, CD4, CD8, CD20, CD4(+)CD25(+), CD4(+)CD29(+), and CD8(+)CD11a(high) cells in peripheral blood from patients with MS (16 stable, 6 active) and NMO (15 stable, 7 active), as well as 9 with NMO spectrum, 6 with clinically isolated syndrome (CIS), and 13 with other neurological diseases using flow cytometry. Significant decreases in the numbers of CD8(+) CD11a(high) cells were observed in stable and active MS and CIS. Our findings indicate that CD8(+)CD11a(high) cells play different roles in MS and NMO, and their presence may be related to the pathogenesis of MS from the early stage.
authors.affiliation: Department of Neurology, Utano National Hospital, Kyoto, Japan. masarum@unh.hosp.jp
authors.forename: Masaru
authors.initials: M
authors.lastname: Matsui
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tahara
authors.forename: Masami
authors.initials: M
authors.lastname: Tanaka
authors.forename: Keiko
authors.initials: K
authors.lastname: Tanaka
authors.forename: Makoto
authors.initials: M
authors.lastname: Matsui
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Konishi
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000276:immunology; D040881:CD11a Antigen / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D002469:Cell Separation; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*; D009471:Neuromyelitis Optica / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D055815:Young Adult
chemical_list: D015703:Antigens, CD; D040881:CD11a Antigen