title: Modeling of hemodynamics arising from malaria infection.
abstract: We propose a numerical model of hemodynamics arising from malaria infection. This model is based on a particle method, where all the components of blood are represented by the finite number of particles. A two-dimensional spring network of membrane particles is employed for expressing the deformation of malaria infected red blood cells (IRBCs). Malaria parasite within the IRBC is modeled as a rigid object. This model is applied to the stretching of IRBCs by optical tweezers, the deformation of IRBCs in shear flow, and the occlusion of narrow channels by IRBCs. We also investigate the effects of IRBCs on the rheological property of blood in micro-channels. Our results indicate that apparent viscosity is drastically increased for the period from the ring stage and the trophozoite stage, whereas it is not altered in the early stage of infection.
authors.affiliation: Department of Bioengineering and Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aramaki Aza Aoba, Sendai 980-8579, Japan. yimai@pfsl.mech.tohoku.ac.jp
authors.forename: Yohsuke
authors.initials: Y
authors.lastname: Imai
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Kondo
authors.forename: Takuji
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Chwee
authors.initials: C
authors.lastname: Teck Lim
authors.forename: Takami
authors.initials: T
authors.lastname: Yamaguchi
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D004912:Erythrocytes; D006801:Humans; D016778:Malaria, Falciparum / Q000503:physiopathology*; D008954:Models, Biological; D010963:Plasmodium falciparum