title: Unreported "de novo" rearrangement of chromosomes 4 and 7.
abstract: Unreported "de novo" rearrangement of chromosomes 4 and 7: Unbalanced rearrangements of the chromosomes are extremely rare and associated with an abnormal phenotype and usually result in an abortion in early pregnancy. The current literature includes reports on the conditions related with rearrangements of chromosome 4 and 7. Herein, we describe a rearrangement between these two chromosomes, which is the first presentation ofa specific translocation t(4;7)(q31;p15) and its consequent phenotype following de novo rearrangement of the chromosomes. It brought into light phenotypic similarities with other aberrations following breakage from adjacent band loci. We hope these features will help further genetic investigations on these chromosome regions.
authors.affiliation: Department of Genetics, Meram Medical Faculty, Selnuk University, Konya, Turkey. drmselman@hotmail.com
authors.forename: M S
authors.initials: MS
authors.lastname: Yildirim
authors.forename: T C
authors.initials: TC
authors.lastname: Oğün
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4; D002897:Chromosomes, Human, Pair 7; D019465:Craniofacial Abnormalities / Q000235:genetics; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D017880:Limb Deformities, Congenital / Q000235:genetics; D014178:Translocation, Genetic; D014421:Turkey