title: Vision-related quality of life after transsphenoidal surgery for pituitary adenoma.
abstract: PURPOSE. To use the 25-item National Eye Institute Visual Function Questionnaire (VFQ-25) to evaluate vision-related quality of life (VR-QOL) in patients with pituitary adenoma who undergo transsphenoidal surgery. METHODS. The VFQ-25 was self-administered by 74 patients with pituitary adenoma before and 3 months after surgery. Pre- and postoperative clinical data were collected, including age, sex, tumor type and size, logarithm of minimum angle of resolution best corrected visual acuity (logMAR BCVA), critical flicker fusion frequency, static perimetry scores (mean deviation [MD] and corrected pattern SD [CPSD]), duration of ocular symptoms, and number of systemic comorbidities. RESULTS. Seventy-four patients with a mean age of 48.2 years were studied. Transsphenoidal surgery for pituitary adenoma significantly improved logMAR BCVA and critical fusion flicker frequency in the worse-seeing eye and MD and CPSD scores in both the better- and worse-seeing eyes (P < 0.001). The VFQ-25 composite score and all subscale scores, except those for the general health and color vision subscales, improved significantly (P < 0.05). A multivariate regression analysis revealed that the preoperative VFQ-25 composite score and the preoperative MD and CPSD scores in the better-seeing eye were related to the postoperative VFQ-25 composite score (P < 0.05). CONCLUSIONS. This study quantitatively demonstrated that transsphenoidal surgery can dramatically improve VR-QOL in pituitary adenoma and that the preoperative VFQ-25 composite score and visual field disturbance in the better-seeing eye are particularly important predictors associated with the postoperative VR-QOL. The use of VFQ-25 provides a more comprehensive overview of the effectiveness of transsphenoidal surgery.
authors.affiliation: Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan. okamotoyoshifumi@yahoo.co.jp
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Okamoto
authors.forename: Fumiki
authors.initials: F
authors.lastname: Okamoto
authors.forename: Shozo
authors.initials: S
authors.lastname: Yamada
authors.forename: Maiko
authors.initials: M
authors.lastname: Honda
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hiraoka
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Oshika
mesh_terms: D000236:Adenoma / Q000503:physiopathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D005260:Female; D005425:Flicker Fusion / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D010911:Pituitary Neoplasms / Q000503:physiopathology / Q000601:surgery*; D011788:Quality of Life; D012044:Regression Analysis; D018434:Sickness Impact Profile; D013100:Sphenoid Bone / Q000601:surgery; D014786:Vision Disorders / Q000503:physiopathology; D014785:Vision, Ocular / Q000502:physiology*; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult