title: Synthesis, chiral resolution, and determination of novel furan lignan derivatives with potent anti-tumor activity.
abstract: A kind of racemic furan lignans were synthesized via a novel route, and two optical isomers were obtained through a selective hydrolization. The absolute configurations were determined by circular dichroism spectroscopy after separated through a preparative column. The different activities of isomers and the racemates were evaluated on QGY-7701 and HeLa cell lines, and compound 2c showed the best activity on QGY-7701 and HeLa cell lines with IC(50) 12 microM and 13 microM, respectively.
authors.affiliation: Department of Medicinal Chemistry, College of Pharmacy, Second Military Medical University, Shanghai, People's Republic of China.
authors.forename: Hai Ling
authors.initials: HL
authors.lastname: Sun
authors.forename: Tian Tian
authors.initials: TT
authors.lastname: Wang
authors.forename: Zhi Liang
authors.initials: ZL
authors.lastname: Lv
authors.forename: Ji Lu
authors.initials: JL
authors.lastname: Feng
authors.forename: Dong Ping
authors.initials: DP
authors.lastname: Geng
authors.forename: Yong Mei
authors.initials: YM
authors.lastname: Li
authors.forename: Ke
authors.initials: K
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D004354:Drug Screening Assays, Antitumor; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D005663:Furans; D017705:Lignans