title: Function after intersphincteric resection for low rectal cancer and its influence on quality of life.
abstract: OBJECTIVE
  The aim of the study was to investigate function and quality of life after different types of intersphincteric resection (ISR).
  
  
  METHODS
  Between January 2006 and February 2008, 45 patients (34 men and 11 women) with distal third rectal cancer underwent curative ISR. Function was evaluated using the Memorial Sloan Kettering Cancer Center bowel function questionnaire and Wexner score, anal manometry and measurements of rectal capacity were also performed. Quality of life was assessed using the Serbian version of the European Organisation for Research and Treatment of Cancer, quality of life questionnaire (EORTC QLQ-C30) and the translated version of the fecal incontinence quality of life scale (FIQL).
  
  
  RESULTS
  There were no postoperative deaths. Partial ISR was performed in 22 (48.9%) patients, subtotal ISR was performed in 19 (42.2%) patients and total ISR was performed in four (8.9%) patients. Anastomotic leakage occurred in nine (20%) patients. Five (11.1%) of 45 patients had major (complete) incontinence and a further six (13.3%) patients had continuing frequent faecal leakage 12 months after ileostomy reversal. There was no significant difference in quality of life between the groups in the EORTC QLQ-C30 scale, but this was significantly altered by internal anal sphincter resection in two of the FIQL scales (coping/behaviour and depression/self-perception).
  
  
  CONCLUSIONS
  Although ISR does not affect quality of life in general, the extent of internal anal sphincter resection has a negative impact on symptom-specific quality of life owing to faecal incontinence.
authors.affiliation: First Surgical Clinic, Clinical Centre of Serbia, Belgrade, Serbia College for Sport and Health, Belgrade, Serbia.
authors.forename: G
authors.initials: G
authors.lastname: Barisic
authors.forename: V
authors.initials: V
authors.lastname: Markovic
authors.forename: M
authors.initials: M
authors.lastname: Popovic
authors.forename: I
authors.initials: I
authors.lastname: Dimitrijevic
authors.forename: P
authors.initials: P
authors.lastname: Gavrilovic
authors.forename: Z
authors.initials: Z
authors.lastname: Krivokapic
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001003:Anal Canal / Q000503:physiopathology* / Q000601:surgery*; D057868:Anastomotic Leak / Q000209:etiology; D003672:Defecation / Q000502:physiology; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D005242:Fecal Incontinence / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011788:Quality of Life / Q000523:psychology*; D020127:Recovery of Function; D012004:Rectal Neoplasms / Q000601:surgery*; D011795:Surveys and Questionnaires