Genetic diversity of growth hormone receptor gene in cattle.
Growth hormone receptor (GHR) belongs to a member of the cytokine receptor superfamily. Polymorphism of presence or absence of an approximately 1.2 kbp LINE-1 element is observed in bovine GHR gene. The present study was carried out for estimating the genetic diversity and the origin of the LINE-1 element in 10 European, Southeastern Asian and East Asian cattle breeds or populations. Genotyping of the LINE-1 revealed predominant LINE-1 presence in European breeds (0.917-0.991), absence in the Bos taurus indicus populations (0.000-0.017), and intermediate presence in Northeast Asian cattle (0.417-0.522). From genetic features of LINE families, LINE-1 of GHR could be attributed to the same origin in both European and Asian cattle, and Asian LINE-1 may not be derived from recent introgression. This result suggested that LINE-1 in bovine GHR gene could have arisen in an ancestral population of Bos taurus taurus.
Lin
Bang Zhong
BZ
Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Nada, Kobe, Japan.
Sasazaki
Shinji
S
Lee
June Heon
JH
Mannen
Hideyuki
H
D000818:Animals; D001947:Breeding; D002417:Cattle / Q000235:genetics*; D014644:Genetic Variation; D005828:Genetics, Population; D020084:Long Interspersed Nucleotide Elements / Q000235:genetics*; D011986:Receptors, Somatotropin / Q000235:genetics*
D011986:Receptors, Somatotropin