title: Clinical outcome of leiomyosarcomas of vascular origin: comparison with leiomyosarcomas of other origin.
abstract: BACKGROUND
  There are no data about the natural history of leiomyosarcoma of vascular origin (vLMS) in comparison with leiomyosarcoma (LMS) of other origin and about the management of advanced disease.
  
  
  METHODS
  Among 1472 patients diagnosed with sarcoma from January 1980 to December 2008 at our institution, 195 patients (13%) had LMS. LMS had a vascular origin in 14 cases (7%).
  
  
  RESULTS
  Patients with vLMS had a significantly worse median metastasis-free survival (MFS) (0.25 versus 9.6 years, P = 0.001) and overall survival (OS; 2.1 versus 7 years, P < 0.0001) than patients with LMS of other origin. On multivariate analysis, grade and vascular origin were the sole independent adverse prognostic factors for OS. Eight metastatic patients with vLMS received a first-line anthracycline chemotherapy regimen. Two patients had partial response, four had stable disease and two had progressive disease. OS of patients with metastatic vLMS was not significantly different from that observed in patients with metastatic LMS of other origin (22.1 versus 16.5 months, P = 0.84).
  
  
  CONCLUSIONS
  Vascular origin is an independent adverse prognostic factor for MFS and OS in patients with LMS. Patients with metastatic vLMS had a similar outcome than patients with metastatic LMS of other origin.
authors.affiliation: Department of Medical Oncology. Electronic address: italiano@bergonie.org.
authors.forename: A
authors.initials: A
authors.lastname: Italiano
authors.affiliation: Department of Medical Oncology.
authors.forename: M
authors.initials: M
authors.lastname: Toulmonde
authors.affiliation: Department of Surgery.
authors.forename: E
authors.initials: E
authors.lastname: Stoeckle
authors.affiliation: Department of Radiology.
authors.forename: M
authors.initials: M
authors.lastname: Kind
authors.affiliation: Department of Radiotherapy.
authors.forename: G
authors.initials: G
authors.lastname: Kantor
authors.affiliation: Department of Pathology, Institut Bergonié, Bordeaux, France.
authors.forename: J-M
authors.initials: JM
authors.lastname: Coindre
authors.affiliation: Department of Medical Oncology.
authors.forename: B
authors.initials: B
authors.lastname: Bui
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D008113:Liver Neoplasms / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D008175:Lung Neoplasms / Q000401:mortality / Q000556:secondary / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D015996:Survival Rate; D016896:Treatment Outcome; D019043:Vascular Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*