Hypoxia-inducible factor-1-dependent mechanisms of vascularization and vascular remodelling.
The vascular system delivers oxygen and nutrients to every cell in the vertebrate organism. Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic/ischaemic vascular responses, driving transcriptional activation of hundreds of genes involved in vascular reactivity, angiogenesis, arteriogenesis, and the mobilization and homing of bone marrow-derived angiogenic cells. This review will focus on the pivotal role of HIF-1 in vascular homeostasis, the involvement of HIF-1 in vascular diseases, and recent advances in targeting HIF-1 for therapy in preclinical models.
Rey
Sergio
S
Vascular Program, Institute for Cell Engineering, The Johns Hopkins University School of Medicine, Broadway Research Building, Suite 671, 733 N. Broadway, Baltimore, MD 21205, USA.
Semenza
Gregg L
GL
D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use; D000818:Animals; D001808:Blood Vessels / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D003097:Collateral Circulation; D003326:Coronary Circulation; D004195:Disease Models, Animal; D015316:Genetic Therapy; D006801:Humans; D000860:Hypoxia / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D051793:Hypoxia-Inducible Factor 1 / Q000235:genetics / Q000378:metabolism*; D007511:Ischemia / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D018919:Neovascularization, Physiologic / Q000187:drug effects / Q000235:genetics; D010100:Oxygen / Q000378:metabolism; D011652:Pulmonary Circulation; D015861:Retinal Neovascularization / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics; D015533:Transcriptional Activation
D043925:Angiogenesis Inducing Agents; D051793:Hypoxia-Inducible Factor 1; D010100:Oxygen