Adult-born SVZ progenitors receive transient synapses during remyelination in corpus callosum.
We found that demyelinated axons formed functional glutamatergic synapses onto adult-born NG2(+) oligodendrocyte progenitor cells (OPCs) migrating from the subventricular zone after focal demyelination of adult mice corpus callosum. This glutamatergic input was substantially reduced compared with endogenous callosal OPCs 1 week after lesion and was lost on differentiation into oligodendrocytes. Therefore, axon-oligodendrocyte progenitor synapse formation is a transient and regulated step that occurs during remyelination of callosal axons.
Etxeberria
Ainhoa
A
Center for Neuroscience Research, Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC 20010-2970, USA.
Mangin
Jean-Marie
JM
Center for Neuroscience Research, Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC 20010-2970, USA.
Aguirre
Adan
A
Center for Neuroscience Research, Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC 20010-2970, USA.
Gallo
Vittorio
V
Center for Neuroscience Research, Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC 20010-2970, USA.
D053687:Adult Stem Cells / Q000502:physiology*; D000818:Animals; D001369:Axons / Q000502:physiology; D002454:Cell Differentiation; D002465:Cell Movement; D003337:Corpus Callosum / Q000293:injuries / Q000503:physiopathology*; D019706:Excitatory Postsynaptic Potentials; D018698:Glutamic Acid / Q000378:metabolism; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009186:Myelin Sheath / Q000502:physiology*; D041681:NIH 3T3 Cells; D009474:Neurons / Q000502:physiology; D009836:Oligodendroglia / Q000502:physiology*; D055153:Stem Cell Niche / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology
D018698:Glutamic Acid