[Inflammation and insulin resistance: chronic renal disease features].
Chronic renal disease is a state of microinflammation and insulin resistance. They both impact on the patient's outcome with an increased cardiovascular morbi-mortality and malnutrition. Current evidence suggests that there is a link between these two abnormal conditions. Recent data show a multiple organ regulatory pathway with a key role of bone, adipose tissue, immune system and central nervous system in energy balance control and glucose homeostasis. Thus, in searching for effective therapies, we should use an integrated approach aimed at modifying integrated outcomes rather than targeting single molecules.
Guebre-Egziabher
Fitsum
F
INSERM U, Lyon, France. fitsum.guebre-egziabher@chu-lyon.fr
Juillard
Laurent
L
Kalbacher
Emilie
E
Bachetta
Justine
J
Fouque
Denis
D
D000273:Adipose Tissue / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D007333:Insulin Resistance / Q000502:physiology*; D007674:Kidney Diseases / Q000503:physiopathology*; D008928:Mitochondria / Q000502:physiology; D009765:Obesity / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology; D012890:Sleep / Q000502:physiology