title: Subgenual cingulate theta activity predicts treatment response of repetitive transcranial magnetic stimulation in participants with vascular depression.
abstract: Repetitive transcranial magnetic stimulation (rTMS) is an effective treatment for depression. Increased metabolism in the anterior cingulate cortex (ACC) is a known predictor for antidepressant response. The authors assessed whether increased theta power within the ACC predicts rTMS response in participants with vascular depression. Sixty-five participants were randomized to active or sham rTMS. Outcome was assessed using the Hamilton Depression Rating Scale. Electroencephalography was obtained, and comparisons were made among each group with a normative database using low-resolution electromagnetic tomography. Results suggest that vascular depression participants respond well to rTMS and that increased low-theta power in the subgenual ACC predicts response to rTMS.
authors.affiliation: Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.
authors.forename: Kenji
authors.initials: K
authors.lastname: Narushima
authors.forename: Laurie M
authors.initials: LM
authors.lastname: McCormick
authors.forename: Thoru
authors.initials: T
authors.lastname: Yamada
authors.forename: Robert W
authors.initials: RW
authors.lastname: Thatcher
authors.forename: Robert G
authors.initials: RG
authors.lastname: Robinson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003865:Major Depressive Disorder / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy*; D004569:Electroencephalography; D005260:Female; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D020521:Stroke / Q000523:psychology*; D013826:Theta Rhythm; D050781:Transcranial Magnetic Stimulation / Q000379:methods*; D016896:Treatment Outcome