Reducing polycystic liver volume in ADPKD: effects of somatostatin analogue octreotide.
OBJECTIVE
No medical treatment is available for polycystic liver disease, a frequent manifestation of autosomal-dominant polycystic kidney disease (ADPKD). In a prospective, randomized, double-blind, crossover study, 6 months of octreotide (40 mg every 28 days) therapy limited kidney volume growth more effectively than placebo in 12 patients with ADPKD.


METHODS
In this secondary, post hoc analysis of the above study, octreotide-induced changes in liver volumes compared with placebo and the relationship between concomitant changes in liver and kidney volumes were evaluated. Those analyzing liver and kidney volumes were blinded to treatment.


RESULTS
Liver volumes significantly decreased from 1595 +/- 478 ml to 1524 +/- 453 ml with octreotide whereas they did not appreciably change with placebo. Changes in liver volumes were significantly different between the two treatment periods (-71 +/- 57 ml versus +14 +/- 85 ml). Octreotide-induced liver volume reduction was fully explained by a reduction in parenchyma volume from 1506 +/- 431 ml to 1432 +/- 403 ml. Changes in liver volumes were significantly correlated with concomitant changes in kidney volumes (r = 0.67) during octreotide but not during placebo treatment. Liver and kidney volume changes significantly differed with both treatments (octreotide: -71 +/- 57 ml versus +71 +/- 107; placebo: +14 +/- 85 ml versus +162 +/- 114), but net reductions in liver (-85 +/- 103 ml) and kidney (-91 +/- 125 ml) volume growth on octreotide versus placebo were similar.


CONCLUSIONS
Octreotide therapy reduces liver volumes in patients with ADPKD and is safe.
Caroli
Anna
A
Biomedical Engineering, Mario Negri Institute for Pharmacological Research, Via Gavazzeni, 11, 24125 Bergamo, Italy.
Antiga
Luca
L
Cafaro
Mariateresa
M
Fasolini
Giorgio
G
Remuzzi
Andrea
A
Remuzzi
Giuseppe
G
Ruggenenti
Piero
P
D000328:Adult; D018592:Cross-Over Studies; D003560:Cysts / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000187:drug effects*; D008099:Liver / Q000000981:diagnostic imaging / Q000187:drug effects*; D008107:Liver Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000009:adverse effects / Q000627:therapeutic use*; D007690:Polycystic Kidney Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D011446:Prospective Studies; D013997:Time Factors; D036542:Tomography, Spiral Computed; D016896:Treatment Outcome
D015282:Octreotide