Calpinactam, a new anti-mycobacterial agent, produced by Mortierella alpina FKI-4905.
Calpinactam, a new anti-mycobacterial agent, was isolated from the culture broth of a fungal strain Mortierella alpina FKI-4905 by solvent extraction, octadecyl silane column chromatography and preparative HPLC. Calpinactam was active only against Mycobacteria among various microorganisms, including Gram-positive and Gram-negative bacteria, fungi and yeasts. Calpinactam inhibited the growth of Mycobacterium smegmatis and Mycobacterium tuberculosis with MIC values of 0.78 and 12.5 microg ml(-1), respectively.
Koyama
Nobuhiro
N
Graduate School of Pharmaceutical Sciences, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo, Japan.
Kojima
Shigenobu
S
Nonaka
Kenichi
K
Masuma
Rokuro
R
Matsumoto
Makoto
M
Omura
Satoshi
S
Tomoda
Hiroshi
H
D000995:Antitubercular Agents / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D002209:Caprolactam / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D006801:Humans; D008826:Microbial Sensitivity Tests; D020094:Mortierella / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D020102:Mycobacterium smegmatis / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009842:Oligopeptides / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology*; D012335:RNA, Ribosomal / Q000737:chemistry / Q000235:genetics
D000995:Antitubercular Agents; D004269:DNA, Bacterial; D021903:DNA, Ribosomal Spacer; D009842:Oligopeptides; D012335:RNA, Ribosomal; C547263:calpinactam; D002209:Caprolactam