Microwave-Assisted Direct Biaryl Coupling: First Application to the Synthesis of Aporphines.
We have investigated the use of microwaves in a direct biaryl coupling reaction for the synthesis of analogs of the aporphine alkaloid nantenine. Our study shows that the aporphine core may be rapidly accessed from benzyl-tetrahydroisoquinoline substrates with this method. This is the first report of a microwave-assisted direct biaryl coupling reaction in the synthesis of aporphine molecules.
Chaudhary
Sandeep
S
Dept. of Chemistry, Hunter College, and the Graduate Center of the City University of New York, 695 Park Avenue, New York, NY 10065, USA.
Pecic
Stevan
S
Legendre
Onica
O
Harding
Wayne W
WW