Purunusides A-C, alpha-glucosidase inhibitory homoisoflavone glucosides from Prunus domestica.
Purunusides A-C (1-3), new homoisoflavone glucosides together with the known compounds beta-sitosterol (4) and 6,7-methylenedioxy-8-methoxycoumarin (5) have been isolated from n-butanol and ethyl acetate soluble fractions of Prunus domestica. Their structures were assigned on the basis of spectral studies. The compounds 1-3 showed potent inhibitory activity against the enzyme alpha-glucosidase.
Kosar
Shaheen
S
Department of Chemistry, University of Karachi, Karachi, 75270, Pakistan.
Fatima
Itrat
I
Mahmood
Azhar
A
Ahmed
Rehana
R
Malik
Abdul
A
Talib
Sumaira
S
Chouhdary
Muhammad Iqbal
MI
D002855:Chromatography, Thin Layer; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry* / Q000494:pharmacology*; D065089:Glycoside Hydrolase Inhibitors; D007529:Isoflavones / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018520:Plant Shoots / Q000737:chemistry; D027861:Prunus / Q000737:chemistry*; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D004791:Enzyme Inhibitors; D005960:Glucosides; D065089:Glycoside Hydrolase Inhibitors; D007529:Isoflavones; D012997:Solvents; C549418:purunuside A; C549419:purunuside B; C549420:purunuside C