title: A new sinus prosthesis for aortic valve-sparing surgery maintaining the shape of the root at systemic pressure.
abstract: OBJECTIVE
  We describe a new prosthetic graft aiming to restore normal valve configuration in systemic circulation. In vitro evaluation data and first clinical results are presented.
  
  
  METHODS
  The aortic valve consists of three separate leaflets and sinuses of Valsalva interconnected through three straight interleaflet triangles. This shape has important implications on valve function.
  
  
  RESULTS
  In vitro tests showed nearly normal hemodynamics, although root distensibility was decreased and bending deformation of the leaflets was increased due to the nonflexibility of the graft material. However, the anatomical shape of the aortic root was well preserved in vitro and also in vivo without contact of leaflets to the prosthesis wall.
  
  
  CONCLUSIONS
  This new sinus prosthesis maintains normal configuration of the aortic root with three distinct sinuses of Valsalva and straight commissural pillars in systemic circulation. The noncompliant material induces abnormal leaflet bending during systole, but leaflets do not collide with the wall of prosthesis.
authors.affiliation: Department of Cardiac Surgery, University Clinic of Schleswig-Holstein, Lübeck, Germany.
authors.forename: Doreen
authors.initials: D
authors.lastname: Richardt
authors.forename: Antje
authors.initials: A
authors.lastname: Karluss
authors.forename: Claudia
authors.initials: C
authors.lastname: Schmidtke
authors.forename: Hans-Hinrich
authors.initials: HH
authors.lastname: Sievers
authors.forename: Michael
authors.initials: M
authors.lastname: Scharfschwerdt
mesh_terms: D000818:Animals; D001014:Aortic Aneurysm / Q000150:complications / Q000601:surgery*; D001021:Aortic Valve / Q000502:physiology*; D001022:Aortic Valve Insufficiency / Q000150:complications / Q000601:surgery*; D001807:Blood Vessel Prosthesis; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D011474:Prosthesis Design; D012850:Sinus of Valsalva / Q000502:physiology; D013552:Swine; D055815:Young Adult