Inflammatory twins from PI3K gang brought to justice?
PI3 kinase inhibitors are hot property. In this issue of Chemistry & Biology, Williams et al. add a dual PI3Kdelta/gamma inhibitor to the collection and show that its anti-inflammatory profile in vitro is quite different from pan-PI3K inhibitors, but bears an uncanny resemblance to that of the glucocorticoid drugs.
Thompson
Philip E
PE
Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville 3052, Australia. philip.thompson@pharm.monash.edu.ac
Jennings
Ian G
IG
Pinson
Jo-Anne
JA