title: [Comparative pharmacokinetics of dihydroquercetin in rats upon peroral administration of a parent compound and liposomal flamen D].
abstract: The pharmacokinetics of dihydroquercetin (DHQ) in the forms of parent substance and a new liposomal formulation (Flamena D) have been studied in rats upon single peroral administration in a dose of 50 mg/kg. DHQ concentration after enzymatic hydrolysis in the blood plasma was determined by HPLC with UV detection. The elimination half-life of DHQ introduced in the form of Flamena D was about T(1/2) = 1.3 h. The relative bioavailability of DHQ after the administration of Flamena D amounted to 159% in comparison to that of the parent substance of DHQ.
authors.forename: V P
authors.initials: VP
authors.lastname: Zherdev
authors.forename: G B
authors.initials: GB
authors.lastname: Kolyvanov
authors.forename: A A
authors.initials: AA
authors.lastname: Litvin
authors.forename: A K
authors.initials: AK
authors.lastname: Sariev
authors.forename: A O
authors.initials: AO
authors.lastname: Viglinskaia
authors.forename: B I
authors.initials: BI
authors.lastname: Gekkiev
authors.forename: A M
authors.initials: AM
authors.lastname: Grigor'ev
authors.forename: V V
authors.initials: VV
authors.lastname: Gorlov
mesh_terms: D000818:Animals; D008081:Liposomes; D008297:Male; D011794:Quercetin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D051381:Rats
chemical_list: D008081:Liposomes; D011794:Quercetin; C003377:taxifolin