title: Novel powerful water-soluble lipid immunoadjuvants inducing mouse dendritic cell maturation and B cell proliferation using TLR2 pathway.
abstract: Four novel water-soluble lipid immunoadjuvants were designed, synthesized and characterized by MS and NMR. They all induce mouse dendritic cell maturation and B cell proliferation. We demonstrate that in spite of the chemical modification, the four compounds remain TLR2 agonists.
authors.affiliation: Equipe de Biovectorologie, Laboratoire de Conception et Application des Molécules Bioactives, UMR 7199 CNRS/Université de Strasbourg, Faculté de Pharmacie, Illkirch Cedex, France.
authors.forename: Maria Vittoria
authors.initials: MV
authors.lastname: Spanedda
authors.forename: Béatrice
authors.initials: B
authors.lastname: Heurtault
authors.forename: Steffen
authors.initials: S
authors.lastname: Weidner
authors.forename: Corinne
authors.initials: C
authors.lastname: Baehr
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Boeglin
authors.forename: Julien
authors.initials: J
authors.lastname: Beyrath
authors.forename: Sara
authors.initials: S
authors.lastname: Milosevic
authors.forename: Line
authors.initials: L
authors.lastname: Bourel-Bonnet
authors.forename: Sylvie
authors.initials: S
authors.lastname: Fournel
authors.forename: Benoît
authors.initials: B
authors.lastname: Frisch
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D049109:Cell Proliferation / Q000187:drug effects*; D003713:Dendritic Cells / Q000166:cytology*; D008055:Lipids / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D012995:Solubility; D051195:Toll-Like Receptor 2 / Q000378:metabolism*; D014867:Water
chemical_list: D000276:Adjuvants, Immunologic; D008055:Lipids; C493486:Tlr2 protein, mouse; D051195:Toll-Like Receptor 2; D014867:Water