Fluorous mixture synthesis of asymmetric dendrimers.
A divergent fluorous mixture synthesis (FMS) of asymmetric fluorinated dendrimers has been developed. Four generations of fluorinated dendrimers with the same fluorinated moiety were prepared with high efficiency, yield, and purity. Comparison of the physicochemical properties of these dendrimers provided valuable information for their application and future optimization. This strategy has not only provided a practical method for the synthesis and purification of dendrimers, but also established the possibility of utilizing the same fluorinated moiety for FMS.
Jiang
Zhong-Xing
ZX
Fischell Department of Bioengineering, University of Maryland, College Park, Maryland 20742, USA.
Yu
Yihua Bruce
YB
D002851:Chromatography, High Pressure Liquid; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry; D005461:Fluorine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D012995:Solubility; D014867:Water / Q000737:chemistry*
D050091:Dendrimers; D014867:Water; D005461:Fluorine