[Antioxidant activity of cytoflavin in experimental diffuse purulent peritonitis].
One of key factors in the development of endogenous intoxication during widespread purulent peritonitis is a disbalance in the free-radical oxidation. A hyperactivation of lipid peroxidation and a decrease in the antioxidant activity cause impairment of the cell mitochondria function. The new metabolic drug cytoflavin possesses pronounced antioxidant properties, provides an effective and fast restoration of the LPO and antioxidant activity balance, and increases the speed of free radical elimination. This investigation confirmed the expediency of including cytoflavin in the complex treatment of widespread purulent peritonitis with the aim of normalizing biological oxidation processes and eliminating endogenous intoxication factors.
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D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D004338:Drug Combinations; D005486:Flavin Mononucleotide / Q000494:pharmacology* / Q000627:therapeutic use; D005609:Free Radicals / Q000378:metabolism; D007290:Inosine Diphosphate / Q000494:pharmacology* / Q000627:therapeutic use; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism; D009536:Niacinamide / Q000494:pharmacology* / Q000627:therapeutic use; D010538:Peritonitis / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery; D011184:Postoperative Period; D011817:Rabbits; D013386:Succinates / Q000494:pharmacology* / Q000627:therapeutic use; D013492:Suppuration
D000975:Antioxidants; D004338:Drug Combinations; D005609:Free Radicals; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate