title: State of the art, nomenclature, and points of consensus and controversy concerning benign melanocytic lesions: outcome of an international workshop.
abstract: The following communication summarizes the proceedings of a one-day International Workshop focusing on the histology of benign melanocytic nevi. Areas of controversy identified in 6 focus sessions were the nomenclature and relationships among common nevi including nevi with halo reactions, traumatized nevi, "dysplastic" nevi, and nevi from particular anatomic sites; developmental biology and frequency of malignant transformation associated with congenital nevi; the characterization and biologic nature of atypical spitzoid neoplasms; the basic definition of particular melanocytic cellular phenotypes, and the nomenclature and biologic nature of many candidate blue nevi, combined nevi, and other controversial lesions such as deep penetrating nevus and pigmented epithelioid melanocytoma. Concentrated data collection and follow-up, molecular characterization, and future consensus Workshops may facilitate the resolution of some of these problems. The Group recommended the description of ambiguous or "borderline" lesions as tumors with indeterminate or uncertain biologic/malignant potential. The participants also advised that such lesions at a minimum should be managed by complete excision with clear surgical margins.
authors.affiliation: Department of Dermatology, Hopital Saint-Louis, Paris, France. raymond.barnhill@sls.aphp.fr
authors.forename: Raymond L
authors.initials: RL
authors.lastname: Barnhill
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Cerroni
authors.forename: Martin
authors.initials: M
authors.lastname: Cook
authors.forename: David E
authors.initials: DE
authors.lastname: Elder
authors.forename: Helmut
authors.initials: H
authors.lastname: Kerl
authors.forename: Philip E
authors.initials: PE
authors.lastname: LeBoit
authors.forename: Stanley W
authors.initials: SW
authors.lastname: McCarthy
authors.forename: Martin C
authors.initials: MC
authors.lastname: Mihm
authors.forename: Wolter J
authors.initials: WJ
authors.lastname: Mooi
authors.forename: Michael W
authors.initials: MW
authors.lastname: Piepkorn
authors.forename: Victor G
authors.initials: VG
authors.lastname: Prieto
authors.forename: Richard A
authors.initials: RA
authors.lastname: Scolyer
mesh_terms: D002648:Child; D003245:Consensus Statements as Topic; D004416:Dysplastic Nevus Syndrome / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D018329:Nevus, Blue / Q000473:pathology; D018332:Nevus, Epithelioid and Spindle Cell / Q000145:classification / Q000151:congenital / Q000473:pathology; D009508:Nevus, Pigmented / Q000145:classification / Q000151:congenital / Q000473:pathology*; D012878:Skin Neoplasms / Q000145:classification / Q000473:pathology