title: The antiplasmodial agents of the stem bark of Entandrophragma angolense (Meliaceae).
abstract: In the search of active principles from the stem bark of Entandrophragma angolense, we submitted the compounds isolated from the dichloromethane-methanol (1:1) extract of the stem bark to antimalarial test against chloroquine resistant strain W2 of Plasmodium falciparum malaria parasite. Only 7alpha-obacunyl acetate and a cycloartane derivative exhibited a good activity, with IC(50)s of 2 and 5.4 microg/ml respectively. Other compounds were moderately active.
authors.affiliation: Institut de Recherches Médicales et d'Etudes des Plantes Médicinales, Laboratoire de Recherche sur le Paludisme, Yaoundé, Cameroon. jbickii@yahoo.fr
authors.forename: Jean
authors.initials: J
authors.lastname: Bickii
authors.forename: Guy Raymond Feuya
authors.initials: GR
authors.lastname: Tchouya
authors.forename: Jean Claude
authors.initials: JC
authors.lastname: Tchouankeu
authors.forename: Etienne
authors.initials: E
authors.lastname: Tsamo