Photoinduced DNA cleavage by formation of ROS from oxygen with a neurotransmitter and aromatic amino acids.
UV-B photoirradiation of a neurotransmitter (serotonin) and aromatic amino acids (tryptophan and tyrosine) with oxygen results in DNA cleavage by generation of reactive oxygen species (ROS) as demonstrated by agarose gel electrophoresis with pBR 322 DNA, ESR and laser flash photolysis measurements.
Kawashima
Tomonori
T
Department of Material and Life Science, Graduate School of Engineering, Osaka University, SORST, Japan Science and Technology Agency (JST), Yamada-oka 2-1, Suita, Osaka 565-0871, Japan.
Ohkubo
Kei
K
Fukuzumi
Shunichi
S
D053837:DNA Cleavage / Q000528:radiation effects*; D010100:Oxygen / Q000378:metabolism*; D055668:Photochemical Processes; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism*; D014466:Ultraviolet Rays
D017382:Reactive Oxygen Species; D012701:Serotonin; D014443:Tyrosine; D014364:Tryptophan; D010100:Oxygen