Effect of air pollution on blood pressure, blood lipids, and blood sugar: a population-based approach.
OBJECTIVE
To investigate changes in blood pressure, lipids, and sugar associated with changes in exposure to ambient air pollution.


METHODS
We conducted secondary analyses of blood pressure and biochemistry markers from Taiwanese Survey on Prevalence of Hyperglycemia, Hyperlipidemia, and Hypertension and air pollution monitoring data in 2002 by applying generalized additive models.


RESULTS
We observed increased particulate matter with aerodynamic diameters <10 microm was associated with elevated systolic blood pressure (an interquartile range, 34 microg/m, for 0.47 mmHg; 95% CI, -0.09 to 1.02), triglyceride, apolipoprotein B, hemoglobin A1c, and reduced high-density lipoprotein cholesterol. Elevated ozone was associated with increased diastolic blood pressure, apolipoprotein B, and hemoglobin A1c.


CONCLUSIONS
Alterations of atherosclerotic indicators are associated with particulate matter with aerodynamic diameters <10 microm and ozone changes. This might provide a link between air pollution and progression of atherosclerotic cardiovascular diseases.
Chuang
Kai-Jen
KJ
Institute of Occupational Medicine and Industrial Hygiene, College of Public Health, National Taiwan University, Taipei, Taiwan.
Yan
Yuan-Horng
YH
Cheng
Tsun-Jen
TJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000393:Air Pollutants / Q000009:adverse effects*; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects*; D004784:Environmental Monitoring; D005260:Female; D006442:Glycated Hemoglobin / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010126:Ozone / Q000009:adverse effects; D052638:Particulate Matter / Q000009:adverse effects; D012044:Regression Analysis; D013624:Taiwan; D055815:Young Adult
D000393:Air Pollutants; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D008055:Lipids; D010126:Ozone; D052638:Particulate Matter; C025617:glucosylated hemoglobin A