Chrysoeriol isolated from the leaves of Eurya ciliata stimulates proliferation and differentiation of osteoblastic MC3T3-E1 cells.
Chrysoeriol (1) was isolated as the main constituent from the methanol extract of the dried leaves of Eurya ciliata Merr. To investigate the bioactivities of 1 on bone metabolism, its effects on the function of osteoblastic MC3T3-E1 cells were studied. Compound 1 significantly increased the growth of MC3T3-E1 cells and caused a significant elevation of alkaline phosphatase activity, collagen content, and nodule mineralization in the cells (P < 0.05). Our data indicate that the enhancement of osteoblast function by 1 may be useful in the prevention of osteoporosis.
Tai
Bui Huu
BH
Chungnam National University, Daejeon, South Korea.
Cuong
Nguyen Manh
NM
Huong
Tran Thu
TT
Choi
Eun-Mi
EM
Kim
Jeong-Ah
JA
Kim
Young Ho
YH
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D002454:Cell Differentiation; D029791:Ericaceae / Q000737:chemistry*; D047309:Flavones; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D010006:Osteoblasts / Q000187:drug effects / Q000378:metabolism*; D018515:Plant Leaves / Q000737:chemistry; D014744:Vietnam
D047309:Flavones; D005419:Flavonoids; D000469:Alkaline Phosphatase; C007054:chrysoeriol