title: Roles of pleiotrophin in tumor growth and angiogenesis.
abstract: Pleiotrophin (PTN) is a heparin-binding growth factor with diverse biological activities, the most studied of these being those related to the nervous system, tumor growth and angiogenesis. Although interest in the involvement of PTN in tumor growth is increasing, many questions remain unanswered, particularly concerning the receptors and the signaling pathways involved. In this review, we briefly introduce PTN, and summarize data on its involvement in tumor growth and angiogenesis, and on what is known to date concerning the receptors and pathways involved.
authors.affiliation: Laboratory of Molecular Pharmacology, Department of Pharmacy, University of Patras, Patras, Greece. epapad@upatras.gr
authors.forename: Evangelia
authors.initials: E
authors.lastname: Papadimitriou
authors.forename: Constantinos
authors.initials: C
authors.lastname: Mikelis
authors.forename: Evgenia
authors.initials: E
authors.lastname: Lampropoulou
authors.forename: Marina
authors.initials: M
authors.lastname: Koutsioumpa
authors.forename: Katerina
authors.initials: K
authors.lastname: Theochari
authors.forename: Sotiria
authors.initials: S
authors.lastname: Tsirmoula
authors.forename: Christina
authors.initials: C
authors.lastname: Theodoropoulou
authors.forename: Margarita
authors.initials: M
authors.lastname: Lamprou
authors.forename: Evanthia
authors.initials: E
authors.lastname: Sfaelou
authors.forename: Dionyssios
authors.initials: D
authors.lastname: Vourtsis
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Boudouris
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D049109:Cell Proliferation; D016207:Cytokines / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000098:blood supply* / Q000235:genetics / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism*; D011401:Promoter Regions, Genetic / Q000235:genetics
chemical_list: D002352:Carrier Proteins; D016207:Cytokines; C066845:pleiotrophin