title: The heat shock connection of metabolic stress and dietary restriction.
abstract: Molecular chaperones and the heat shock response guard and modulate protein conformation, protect proteins from misfolding and aggregation, and maintain signalling and organellar networks. Overnutrition and the metabolic syndrome represent a pro-aging condition, and dietary restriction is the most robust environmental intervention that induces longevity from yeast to mammals. In recent years a considerable effort has been made to elucidate the signaling pathways involved in metabolic signaling. Here we review the current understanding on the connection between metabolic stress, dietary restriction and the heat shock response and highlight results showing chaperone induction as a promising therapeutic strategy to promote healthy aging and to prevent metabolic disorders.
authors.affiliation: Department of Medical Chemistry, Semmelweis University, Budapest, Hungary.
authors.forename: Balázs
authors.initials: B
authors.lastname: Dancsó
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Spiró
authors.forename: Mehmet Alper
authors.initials: MA
authors.lastname: Arslan
authors.forename: Minh Tú
authors.initials: MT
authors.lastname: Nguyen
authors.forename: Diána
authors.initials: D
authors.lastname: Papp
authors.forename: Péter
authors.initials: P
authors.lastname: Csermely
authors.forename: Csaba
authors.initials: C
authors.lastname: Soti
mesh_terms: D000818:Animals; D031204:Caloric Restriction; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008136:Longevity / Q000235:genetics / Q000502:physiology; D008659:Metabolic Diseases / Q000378:metabolism* / Q000517:prevention & control; D015398:Signal Transduction; D013312:Stress, Physiological / Q000235:genetics / Q000502:physiology
chemical_list: D006360:Heat-Shock Proteins