title: The histopathologic type of the periampullary tumors. Is it important for survival?
abstract: BACKGROUND
  The ampulla of Vater is a junction with four histologic epithelial types: ampullary, duodenal, pancreatic and biliary. The tumors of this region are named periampullary adenocarcinomas, but the histologic type of these malignancies seems to have an important significance for survival.
  
  
  OBJECTIVE
  Our purpose is to determine whether the histologic type of the resectable vaterian adenocarcinomas is a prognostic factor.
  
  
  METHODS
  We reviewed the medical records of 38 patients who underwent RO-R1 pancreatoduodenectomy for periampullary adenocarcinomas between 1998 and 2007 in one single surgical center. The histopathologic reports and the microscopic samples were reevaluated independently by two senior pathologists. Using our database we assessed the overall survival based on histologic type, tumor stage, lymph nodes involvement, tumor size and the level of differentiation.
  
  
  RESULTS
  The histologic type of the adenocarcinomas was intestinal in 23 cases (60.5%) and pancreatobiliary in 15 cases (39.5%). The median overall survival was significantly higher in patients with well differentiate intestinal-type in T1-T2 stage without nodes involvement. In a multivariable Cox regression analysis the regional lymph nodes involvement and the differentiation degree remained significant prognostic factors.
  
  
  CONCLUSIONS
  The intestinal type of periampullary adenocarcinomas has a long survival, but the lymph nodes involvement and the lower degree of differentiation are associated with a high risk of death in these malignancies.
authors.affiliation: 1st Surgical Clinic, Sf. Spiridon Hospital, Gr. T. Popa University of Medicine and Pharmacy Iaşi, Romania. stefanogeorgescu@gmail.com
authors.forename: St O
authors.initials: SO
authors.lastname: Georgescu
authors.forename: C N
authors.initials: CN
authors.lastname: Neacşu
authors.forename: D
authors.initials: D
authors.lastname: Vintilă
authors.forename: P
authors.initials: P
authors.lastname: Popa
authors.forename: N
authors.initials: N
authors.lastname: Florea
authors.forename: M S
authors.initials: MS
authors.lastname: Mihailovici
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000473:pathology / Q000601:surgery; D004379:Duodenal Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008499:Medical Records; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D016577:Pancreaticoduodenectomy / Q000401:mortality; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012383:Romania / Q000453:epidemiology; D016019:Survival Analysis; D016896:Treatment Outcome