title: Synthesis of novel 5'-uridine-head amphiphiles as model for DNA molecular recognition.
abstract: Here we describe uridine functionalization in the 5' position, which provides new classes of cationic and nonionic amphiphiles specifically designed as DNA transfection agents. The synthetic procedures developed to obtain the cationic uridine-head surfactants prevented intramolecular cyclization that occurs when uridine is functionalized in this position without using protecting groups in the uracil.
authors.affiliation: CEMIN-Excellence Centre on Innovative Nanostructured Materials, Department of Chemistry, University of Perugia, Perugia, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Tiecco
authors.forename: Pietro
authors.initials: P
authors.lastname: Di Profio
authors.forename: Raimondo
authors.initials: R
authors.lastname: Germani
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Savelli
mesh_terms: D003500:Cyclization; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D014162:Transfection; D014529:Uridine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D013501:Surface-Active Agents; D004247:DNA; D014529:Uridine