title: Detrusor overactivity: an overview.
abstract: Detrusor overactivity (DO) is a common clinical problem having profound effects on the quality of life (QOL) of women. With the use of meshes in the antiincontinence surgery, a new onset of DO, de novo DO has become an important issue in postoperative QOL of women. A systematic review of English language literature was conducted from Pubmed and publications of the last 7 years were analyzed and presented in this review. Multiple pathological events in the urothelium, sub-urothelium and possibly in the detrusor muscle seem to underlie the pathophysiology of DO. A variety of approaches, from life style modification to minimal-invasive surgery are available to treat DO and it is the responsibility of the physician to properly select and apply these modalities with the ultimate aim in improving the QOL of the patients. It is imperative to know the various pathophysiological processes that underlie the causation of DO to select proper management approach.
authors.affiliation: Department of Urogynecology, Chang-Gung Memorial Hospital, Linkou, Taiwan. drkirana@gmail.com
authors.forename: Kiran
authors.initials: K
authors.lastname: Ashok
authors.forename: Alex
authors.initials: A
authors.lastname: Wang
mesh_terms: D001905:Botulinum Toxins / Q000627:therapeutic use; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D005260:Female; D006801:Humans; D009130:Muscle, Smooth / Q000503:physiopathology; D011788:Quality of Life; D001750:Urinary Bladder, Neurogenic / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy; D053201:Urinary Bladder, Overactive / Q000503:physiopathology* / Q000523:psychology / Q000628:therapy; D014563:Urodynamics / Q000502:physiology*
chemical_list: D018680:Cholinergic Antagonists; D001905:Botulinum Toxins