[Effects of SERMs on bone health. Efficacy of SERM for incidence of fractures in osteoporotic patients with lifestyle-related diseases].
Osteoporosis is closely associated with lifestyle-related diseases, such as diabetes mellitus, hypertension, and hyperlipidemia. The meta-analysis data reveals that risk of hip fracture is higher in the patients with diabetes mellitus or hypertension compared with those without it. Bone quality more markedly contributes to bone strength in osteoporosis associated with diabetes mellitus than without it. The reduction rate of vertebral fractures by raloxifene in the osteoporotic women with diabetes mellitus is higher than or equal to those without it. Raloxifene more markedly reduces vertebral fractures in the osteoporotic women with high value of serum triglyceride. Raloxifene improves hyperlipidemia in the postmenopausal osteoporotic women and increases the value of serum adiponection in the postmenopausal osteoporotic women without diabetes mellitus.
Sakai
Akinori
A
Department of Orthopaedic Surgery, University of Occupational and Environmental Health.
Nakamura
Toshitaka
T
D052242:Adiponectin / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000188:drug therapy; D006973:Hypertension / Q000150:complications; D008019:Life Style; D015201:Meta-Analysis as Topic; D015663:Osteoporosis, Postmenopausal / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D020849:Raloxifene Hydrochloride / Q000627:therapeutic use*; D012306:Risk; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use*; D015398:Signal Transduction / Q000502:physiology; D016103:Spinal Fractures / Q000209:etiology* / Q000517:prevention & control*; D051153:Wnt Proteins / Q000502:physiology; D051176:beta Catenin / Q000502:physiology
D052242:Adiponectin; D020845:Selective Estrogen Receptor Modulators; D051153:Wnt Proteins; D051176:beta Catenin; D020849:Raloxifene Hydrochloride