title: A new facile synthesis of 3-amidoindole derivatives and their evaluation as potential GSK-3beta inhibitors.
abstract: 3-Amidoindoles were synthesized from commercially available arylhydrazines and propargylamines over Zn-salt mediated one pot procedure in excellent regioselectivity and up to 94% yield.
authors.affiliation: Leibniz-Institut für Katalyse e.V. an der Universität Rostock, Albert-Einstein-Str. 29a, D-18059, Rostock, Germany.
authors.forename: Anahit
authors.initials: A
authors.lastname: Pews-Davtyan
authors.forename: Annegret
authors.initials: A
authors.lastname: Tillack
authors.forename: Anne-Caroline
authors.initials: AC
authors.lastname: Schmöle
authors.forename: Stefanie
authors.initials: S
authors.lastname: Ortinau
authors.forename: Moritz J
authors.initials: MJ
authors.lastname: Frech
authors.forename: Arndt
authors.initials: A
authors.lastname: Rolfs
authors.forename: Matthias
authors.initials: M
authors.lastname: Beller
mesh_terms: D002460:Cell Line; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology*; D015394:Molecular Structure; D051176:beta Catenin / Q000378:metabolism
chemical_list: D007211:Indoles; D051176:beta Catenin; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3