title: Inflammation and Parkinson's disease pathogenesis.
abstract: Inflammation is a neuropathological feature of parkinsonian brains and also in experimental models of the disease. It is believed that activated glial cells, which compose the majority of this inflammatory response contribute to the neurodegenerative process through the production of toxic molecules. Therapeutic strategies geared toward reducing inflammation and inhibiting the production of these glial-derived toxic molecules may be a promising neuroprotective strategy for the treatment of Parkinson's disease and related conditions.
authors.affiliation: Department of Neurology, Pathology and Cell Biology, Columbia University, New York, New York, USA. SP30@Columbia.edu
authors.forename: Serge
authors.initials: S
authors.lastname: Przedborski
mesh_terms: D000818:Animals; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D009457:Neuroglia / Q000502:physiology*; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology
chemical_list: D051546:Cyclooxygenase 2; D004298:Dopamine