Cytokines across the night in chronic fatigue syndrome with and without fibromyalgia.
The symptoms of chronic fatigue syndrome (CFS) are consistent with cytokine dysregulation. This has led to the hypothesis of immune dysregulation as the cause of this illness. To further test this hypothesis, we did repeated blood sampling for cytokines while patients and matched healthy controls slept in the sleep lab. Because no one method for assaying cytokines is acknowledged to be better than another, we assayed for protein in serum, message in peripheral blood lymphocytes (PBLs), and function in resting and stimulated PBLs. We found no evidence of proinflammatory cytokine upregulation. Instead, in line with some of our earlier studies, we did find some evidence to support a role for an increase in interleukin-10, an anti-inflammatory cytokine. Although the changes were small, they may contribute to the common complaint in CFS patients of disrupted sleep.
Nakamura
Toru
T
Pain & Fatigue Study Center, UMDNJ--New Jersey Medical School, Newark, New Jersey 07103, USA.
Schwander
Stephan K
SK
Donnelly
Robert
R
Ortega
Felix
F
Togo
Fumiharu
F
Broderick
Gordon
G
Yamamoto
Yoshiharu
Y
Cherniack
Neil S
NS
Rapoport
David
D
Natelson
Benjamin H
BH
D000328:Adult; D016207:Cytokines / Q000032:analysis*; D015673:Fatigue Syndrome, Chronic / Q000150:complications* / Q000276:immunology*; D005260:Female; D005356:Fibromyalgia / Q000473:pathology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008875:Middle Aged; D012890:Sleep
D016207:Cytokines