[Clinical value of artificial insemination by donor].
OBJECTIVE
To investigate the clinical value of artificial insemination by donor (AID).


METHODS
We retrospectively analyzed 480 cycles of AID among 258 infertile couples, who were divided according to the women's age into a < or = 30 yr group and a > or = 31 yr group.


RESULTS
A total of 120 pregnancies were achieved in 480 AID cycles, with a cycle pregnancy rate of 25.00% and a cumulative pregnancy rate of 46.51%. In the natural cycles, the cycle pregnancy rate was 29.65% and the cumulative pregnancy rate was 51.00% in the < or = 30 yr group, significantly higher than 13.33% and 25.00% in the > or = 31 yr group (P < 0.05). In the ovulation induction cycles, no significant differences were found in the cycle and cumulative pregnancy rates between the two groups (24.02 and 48.86% versus 23.81 and 43.48% , P > 0.05). The cycle and cumulative pregnancy rates decreased with the increase of infertility duration and the women's age, but had no significant differences. In the first four cycles, the cycle pregnancy rates were 24.03, 24.94, 24.69 and 25.00% (P > 0.05), and the cumulative pregnancy rates were 24.03, 39.53, 45.74 and 46.51%, with significant differences between the first cycle and the other three (P < 0.01).


CONCLUSIONS
Ovulation induction is superior to natural cycle in AID for older women. IVF/ICSI can be resorted to only after AID has failed three or four times.
Zhang
Yan
Y
Department of Clinical Reproductive Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China. zhangyan5758@126.com
Chen
Xiao-Qing
XQ
Yang
Xiao-Yu
XY
Dong
Juan
J
Qian
Xiao-Qiao
XQ
Wang
Wei
W
Mao
Yun-Dong
YD
Liu
Jia-Yin
JY
D000328:Adult; D053713:Azoospermia / Q000628:therapy*; D005260:Female; D006801:Humans; D007316:Insemination, Artificial, Heterologous; D008297:Male; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies