title: Pt-catalyzed hydrative cyclization of 2-enynylbenzaldehydes and its application to faveline synthesis.
abstract: Various 2-[6-en-1-ynyl]benzaldehydes and their analogues were successfully cyclized via Huisgen-type [3+2] cycloaddition to the tetracyclic platinum-carbene complex, which would subsequently undergo hydration to afford the tricyclic products in good yields with excellent stereoselectivities. This hydrative cyclization was also applied to the faveline synthesis.
authors.affiliation: Department of Chemistry, Institute of Natural Science, Hanyang University, Sungdong-Gu, Seoul 133-791, Korea. changho@hanyang.ac.kr
authors.forename: Chang Ho
authors.initials: CH
authors.lastname: Oh
authors.forename: Sung Min
authors.initials: SM
authors.lastname: Lee
authors.forename: Chang Seop
authors.initials: CS
authors.lastname: Hong
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D001547:Benzaldehydes / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D003986:Dibenzocycloheptenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009944:Organoplatinum Compounds / Q000737:chemistry*; D010984:Platinum / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D001547:Benzaldehydes; D003986:Dibenzocycloheptenes; D009944:Organoplatinum Compounds; C549997:faveline methyl ether; D010984:Platinum