title: Therapeutic impact of [(18)F]fluoride positron-emission tomography/computed tomography on patients with unclear foot pain.
abstract: OBJECTIVE
  To evaluate the therapeutic impact of [(18)F]fluoride positron-emission tomography/computed tomography ([(18)F]fluoride PET/CT) imaging on patients with unclear foot pain.
  
  
  METHODS
  Twenty-eight patients were prospectively included in this study. Therapeutic management was defined by two experienced dedicated foot surgeons before and after [(18)F]fluoride PET/CT imaging. Twenty-six patients underwent cross-sectional imaging [CT, magnetic resonance (MR)] prior to PET/CT. A retrospective analysis of the magnetic resonance imaging (MRI) diagnoses was performed when a therapy change occurred after PET/CT imaging.
  
  
  RESULTS
  In 13/28 (46%) patients therapeutic management was changed due to PET/CT results. Management changes occurred in patients with the following diagnoses: os trigonum syndrome; sinus tarsi syndrome; os tibiale externum syndrome; osteoarthritis of several joints; non-consolidated fragments; calcaneo-navicular coalition; plantar fasciitis; insertional tendinopathy; suggestion of periostitis; neoarticulations between metatarsal bones. Os trigonum, os tibiale externum, subtalar osteoarthritis and plantar fasciitis were only seen to be active on PET/CT images but not on MR images.
  
  
  CONCLUSIONS
  [(18)F]fluoride PET/CT has a substantial therapeutic impact on management in patients with unclear foot pain.
authors.affiliation: Department of Nuclear Medicine, University Hospital of Zurich, Rämistrasse 100, 8091, Zurich, Switzerland. dorothee.fischer@usz.ch
authors.forename: Dorothee Rita
authors.initials: DR
authors.lastname: Fischer
authors.forename: Gerardo J
authors.initials: GJ
authors.lastname: Maquieira
authors.forename: Norman
authors.initials: N
authors.lastname: Espinosa
authors.forename: Marco
authors.initials: M
authors.lastname: Zanetti
authors.forename: Rolf
authors.initials: R
authors.lastname: Hesselmann
authors.forename: Anass
authors.initials: A
authors.lastname: Johayem
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Hany
authors.forename: Gustav K
authors.initials: GK
authors.lastname: von Schulthess
authors.forename: Klaus
authors.initials: K
authors.lastname: Strobel
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D005528:Foot / Q000000981:diagnostic imaging; D005534:Foot Diseases / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D010146:Pain / Q000209:etiology; D059408:Pain Management; D049268:Positron-Emission Tomography / Q000379:methods; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18