title: Synthesis and in vitro Efficacy Studies of Silver Carbene Complexes on Biosafety Level 3 Bacteria.
abstract: A series of N-heterocyclic carbene silver complexes have been synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burkholderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assays demonstrated the exceptional efficacy of the complexes against these potentially weaponizable pathogens.
authors.affiliation: Department of Chemistry, University of Akron, Akron, OH 44325-3601, USA.
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Panzner
authors.forename: Arpaporn
authors.initials: A
authors.lastname: Deeraksa
authors.forename: Alyssa
authors.initials: A
authors.lastname: Smith
authors.forename: Brian D
authors.initials: BD
authors.lastname: Wright
authors.forename: Khadijah M
authors.initials: KM
authors.lastname: Hindi
authors.forename: Aysegul
authors.initials: A
authors.lastname: Kascatan-Nebioglu
authors.forename: Alfredo G
authors.initials: AG
authors.lastname: Torres
authors.forename: Barbara M
authors.initials: BM
authors.lastname: Judy
authors.forename: Christine E
authors.initials: CE
authors.lastname: Hovis
authors.forename: Julia K
authors.initials: JK
authors.lastname: Hilliard
authors.forename: Rebekah J
authors.initials: RJ
authors.lastname: Mallett
authors.forename: Emily
authors.initials: E
authors.lastname: Cope
authors.forename: D Mark
authors.initials: DM
authors.lastname: Estes
authors.forename: Carolyn L
authors.initials: CL
authors.lastname: Cannon
authors.forename: Jeff G
authors.initials: JG
authors.lastname: Leid
authors.forename: Wiley J
authors.initials: WJ
authors.lastname: Youngs