Dendritic cell subsets digested: RNA sensing makes the difference!
In this issue of Immunity, Luber et al. (2010) report a comprehensive quantitative proteome of in vivo mouse spleen dendritic cell (DC) subsets: a data set of encyclopedic value already revealing that DC subsets exploit different RNA sensors for virus recognition.
Buschow
Sonja I
SI
Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, the Netherlands.
Figdor
Carl G
CG
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism; D000818:Animals; D002469:Cell Separation; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D005434:Flow Cytometry; D020869:Gene Expression Profiling; D054884:Host-Pathogen Interactions / Q000276:immunology; D051379:Mice; D040901:Proteomics; D012367:RNA, Viral / Q000276:immunology*; D051192:Receptors, Pattern Recognition / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology*; D014780:Viruses / Q000235:genetics / Q000276:immunology*
D048868:Adaptor Proteins, Signal Transducing; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases; D012367:RNA, Viral; D051192:Receptors, Pattern Recognition; C512612:MAVS protein, mouse; C503356:Ddx58 protein, mouse