title: High-frequency oscillations in epileptic brain.
abstract: OBJECTIVE
  It has been 10 years since pathological high-frequency oscillations (pHFOs) were described in the brain of epileptic animals and patients. This review summarizes progress in research on mechanisms of their generation and potential clinical applications over that period.
  
  
  RESULTS
  Initially, pHFOs were recorded with microelectrodes in the hippocampus of rodents and patients with mesial temporal lobe epilepsy (MTLE), but recently pHFOs have also been recorded with clinical depth and grid electrodes in multiple brain areas including the hippocampus and neocortex of patients with different types of epilepsy. One hypothesis is that pHFOs reflect fields of hypersynchronized action potentials (bursts of population spikes) within small discrete neuronal clusters responsible for seizure generation. Studies suggest that pHFOs can be used as a reliable biomarker for epileptogenesis, epileptogenicity, and the delineation of the epileptogenic region.
  
  
  CONCLUSIONS
  Recording of pHFOs with clinical electrodes provides a means for further investigation of their functional role in the epileptic brain and as a potential biomarker of epileptogenesis and epileptogenicity and for presurgical mapping.
authors.affiliation: Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
authors.forename: Anatol
authors.initials: A
authors.lastname: Bragin
authors.forename: Jerome
authors.initials: J
authors.lastname: Engel
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Staba
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology*; D004827:Epilepsy / Q000503:physiopathology*; D006801:Humans; D010507:Periodicity; D012640:Seizures / Q000503:physiopathology