title: Synthesis of an enantiopure isoxazolidine monomer for β-aspartic acid in chemoselective β-oligopeptide synthesis.
abstract: The synthesis of an enantiopure isoxazolidine monomer for the incorporation of β(3)-apartic acid residues into β(3)-oligopeptides via chemoselective α-ketoacid-hydroxylamine amide formation. This route involves nitrone cycloaddition of 3-thiophenylpropanal and circumvents limitations of other potential starting materials.
authors.affiliation: Roy and Diana Vagelos Laboratories, Department of Chemistry, Univeristy of Pennsylvania, Philadelphia, PA 19104.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ishida
authors.forename: Nancy
authors.initials: N
authors.lastname: Carrillo
authors.forename: Jeffrey W
authors.initials: JW
authors.lastname: Bode