title: Radiation dose-volume effects in the lung.
abstract: The three-dimensional dose, volume, and outcome data for lung are reviewed in detail. The rate of symptomatic pneumonitis is related to many dosimetric parameters, and there are no evident threshold "tolerance dose-volume" levels. There are strong volume and fractionation effects.
authors.affiliation: Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27514, USA. marks@med.unc.edu
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Marks
authors.forename: Soren M
authors.initials: SM
authors.lastname: Bentzen
authors.forename: Joseph O
authors.initials: JO
authors.lastname: Deasy
authors.forename: Feng-Ming Spring
authors.initials: FM
authors.lastname: Kong
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Bradley
authors.forename: Ivan S
authors.initials: IS
authors.lastname: Vogelius
authors.forename: Issam
authors.initials: I
authors.lastname: El Naqa
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Hubbs
authors.forename: Joos V
authors.initials: JV
authors.lastname: Lebesque
authors.forename: Robert D
authors.initials: RD
authors.lastname: Timmerman
authors.forename: Mary K
authors.initials: MK
authors.lastname: Martel
authors.forename: Andrew
authors.initials: A
authors.lastname: Jackson
mesh_terms: D006801:Humans; D008168:Lung / Q000528:radiation effects*; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy; D008954:Models, Biological; D015233:Models, Statistical; D017564:Radiation Pneumonitis / Q000209:etiology*; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage