A deadly migration.
CD95 has long been viewed as a death receptor regulating apoptosis. In this issue of Immunity, Letellier et al. (2010) tell us a different story, about the capability of CD95L to regulate leukocyte recruitment to sites of inflammation.
Constantin
Gabriela
G
Department of Pathology, Division of General Pathology, University of Verona, Strada le Grazie 8, I-37134 Verona, Italy.
Laudanna
Carlo
C
D000818:Animals; D002448:Cell Adhesion / Q000276:immunology; D002465:Cell Movement / Q000276:immunology*; D053222:Fas Ligand Protein / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007249:Inflammation; D016023:Integrins / Q000378:metabolism; D051379:Mice; D022423:Myeloid Cells / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D013116:Spinal Cord / Q000276:immunology / Q000473:pathology; D019061:src-Family Kinases / Q000378:metabolism
D053222:Fas Ligand Protein; D016023:Integrins; D019869:Phosphatidylinositol 3-Kinases; D019061:src-Family Kinases