Elevated serum IL-8 levels in ataxia telangiectasia.
Serum interleukin (IL)-8 levels were measured in 50 patients with ataxia telangiectasia (A-T) and 22 without A-T. In a cross-sectional study, the geometric mean of IL-8 level was significantly higher in the patients with A-T (P <.0001). Elevated serum IL-8 levels in patients with A-T suggest that systemic inflammation may contribute to the disease phenotype.
McGrath-Morrow
Sharon A
SA
Division of Pediatric Pulmonology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA. smorrow@jhmi.edu
Collaco
J Michael
JM
Crawford
Thomas O
TO
Carson
Kathryn A
KA
Lefton-Greif
Maureen A
MA
Zeitlin
Pamela
P
Lederman
Howard M
HM
D000293:Adolescent; D000328:Adult; D001260:Ataxia Telangiectasia / Q000097:blood* / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D016516:CD4-CD8 Ratio; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007118:Immunoassay; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult; D000509:alpha-Fetoproteins / Q000378:metabolism
D015415:Biomarkers; D016209:Interleukin-8; D000509:alpha-Fetoproteins; D002097:C-Reactive Protein