title: Syntheses of water-soluble [60]fullerene derivatives and their enhancing effect on neurite outgrowth in NGF-treated PC12 cells.
abstract: Water-soluble [60]fullerene (C(60)) derivatives were synthesized to examine their bioactivities. PC12 cells were used as a model of nerve cells and the bioactivities of synthesized C(60) derivatives together with some reported ones were tested. Among the compounds tested, C(60)/(gamma-CyD)(2), C(60)-bis(gamma-CyD) (5) containing C(60)-mono(gamma-CyD) (5'), and C(60)/PVP were sufficiently soluble in water and showed an enhancing effect on the neurite outgrowth of NGF-treated PC12 cells.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho-ku, Nagoya, Aichi, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Tsumoto
authors.forename: Syo
authors.initials: S
authors.lastname: Kawahara
authors.forename: Yuki
authors.initials: Y
authors.lastname: Fujisawa
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Suzuki
authors.forename: Hidehiko
authors.initials: H
authors.lastname: Nakagawa
authors.forename: Kohfuku
authors.initials: K
authors.lastname: Kohda
authors.forename: Naoki
authors.initials: N
authors.lastname: Miyata
mesh_terms: D000818:Animals; D037741:Fullerenes / Q000737:chemistry* / Q000494:pharmacology*; D020932:Nerve Growth Factor / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects*; D016716:PC12 Cells; D051381:Rats; D012995:Solubility; D014867:Water
chemical_list: D037741:Fullerenes; D014867:Water; D020932:Nerve Growth Factor; C069837:fullerene C60