title: [Analysis of clinical features of community-acquired pneumonia caused by pediatric respiratory syncytial virus and human metapneumovirus].
abstract: We retrospectively reviewed the background, clinical features, blood tests, and complications in the 720 children seen for acute respiratory tract infection from July 2004 to December 2005. Of these, 75 (10.5%) were diagnosed with pneumonia due to respiratory syncytial virus (RSV) and 19 (2.6%) with pneumonia due to human metapneumovirus (hMPV) based on multiplex PCR analysis of nasopharyngeal samples. RSV was PCR-positive mostly in winter, -from November to January-, and hMPV mostly in spring, -from March to June. The mean RSV pneumonia group age was 1.3 +/- 1.4 years and in the hMPV pneumonia group 3.0 +/- 3.1 years, showing a statistically significant differences in the age of virus onset. Clinically the RSV group showed more rhinorrhea and wheezing (p < 0.05) and the hMPV group a higher maximum body temperature and a longer wheezing duration (p < 0.05). Fever, cough, vomiting, diarrhea, fever frequency, and C-reactive protein level were similar in both groups (p > 0.05). Complication prevalence was 49.3% in the RSV group and 42.1% in the hMPV group. Acute otitis media was seen more often in the RSV group (32.0%) and febrile convulsion more often in the hMPV group (15.8%) (p > 0.05). These findings may be helpful in clinically diagnosing community-acquired pneumonia due to RSV or hMPV.
authors.affiliation: Department of Pediatrics, National Hospital Organization Tokyo Medical Center.
authors.forename: Takafumi
authors.initials: T
authors.lastname: Okada
authors.forename: Keita
authors.initials: K
authors.lastname: Matsubara
authors.forename: Takahiro
authors.initials: T
authors.lastname: Matsushima
authors.forename: Osamu
authors.initials: O
authors.lastname: Komiyama
authors.forename: Nahoko
authors.initials: N
authors.lastname: Chiba
authors.forename: Keiko
authors.initials: K
authors.lastname: Hamano
authors.forename: Miyuki
authors.initials: M
authors.lastname: Morozumi
authors.forename: Kimiko
authors.initials: K
authors.lastname: Ubukata
authors.forename: Keisuke
authors.initials: K
authors.lastname: Sunakawa
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iwata
mesh_terms: D000367:Age Factors; D017714:Community-Acquired Infections / Q000453:epidemiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D029121:Metapneumovirus; D018184:Paramyxoviridae Infections / Q000453:epidemiology; D011024:Pneumonia, Viral / Q000453:epidemiology; D018357:Respiratory Syncytial Virus Infections / Q000453:epidemiology; D012189:Retrospective Studies; D014041:Tokyo / Q000453:epidemiology