Chemoselective deprotection of triethylsilyl ethers.
An efficient and selective method was developed for the deprotection of triethylsilyl (TES) ethers using formic acid in methanol (5-10%) or in methylene chloride 2-5%) with excellent yields. TES ethers are selectively deprotected to the corresponding alcohols in high yields using formic acid in methanol under mild reaction conditions. Other hydroxyl protecting groups like t-butyldimethylsilyl (TBDMS) remain unaffected.
Chandra
Tilak
T
Department of Chemistry and Biochemistry Montana State University, Bozeman, MT 59717, USA.
Broderick
William E
WE
Broderick
Joan B
JB
D004987:Ethers / Q000737:chemistry*; D005561:Formates / Q000737:chemistry; D000432:Methanol / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
D004987:Ethers; D005561:Formates; D014297:Trimethylsilyl Compounds; C030544:formic acid; D000432:Methanol