title: Synthesis of β-Heteroaryl Propionates via Trapping of Carbocations with π-Nucleophiles.
abstract: A variety of heterocyclic alcohols and acetates were coupled with silyl ketene acetals and other π-nucleophiles in the presence of trimethylsilyl trifluoromethanesulfonate to provide an array of substituted β-heteroaryl propionates, including those with contiguous quaternary centers, as well as vinylogs thereof. This reaction also proceeds with high diastereoselectivity when the π-nucleophile bears a chiral auxiliary.
authors.affiliation: Department of Chemistry and Biochemistry, The University of Texas, Austin, TX USA 78712.
authors.forename: Tsung-Hao
authors.initials: TH
authors.lastname: Fu
authors.forename: Amy
authors.initials: A
authors.lastname: Bonaparte
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Martin