title: Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain.
abstract: The in vitro activity of TR-700 (torezolid) was evaluated against a collection of 660 staphylococcal blood isolates. TR-700 showed excellent activity against all the staphylococci tested. The MIC(50) and MIC(90) values of TR-700, linezolid, daptomycin, and vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) isolates were 0.25 and 0.5, 2 and 4, 0.5 and 0.5, and 1 and 2 microg/ml, respectively. TR-700 demonstrated greater in vitro potency than linezolid against staphylococci, including linezolid-resistant and vancomycin-nonsusceptible strains, and was 32-fold more active than linezolid against the seven cfr-positive MRSA strains tested.
authors.affiliation: Servicio de Microbiología Clínica, Hospital Clínico San Carlos, Madrid, Spain. cbetriu.hcsc@salud.madrid.org
authors.forename: Carmen
authors.initials: C
authors.lastname: Betriu
authors.forename: Gracia
authors.initials: G
authors.lastname: Morales
authors.forename: Icíar
authors.initials: I
authors.lastname: Rodríguez-Avial
authors.forename: Esther
authors.initials: E
authors.lastname: Culebras
authors.forename: María
authors.initials: M
authors.lastname: Gómez
authors.forename: Fátima
authors.initials: F
authors.lastname: López-Fabal
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Picazo
mesh_terms: D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017576:Daptomycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D066298:In Vitro Techniques; D000069349:Linezolid; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology*; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology; D013030:Spain; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013777:Tetrazoles / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D013777:Tetrazoles; D014640:Vancomycin; C546016:tedizolid; D000069349:Linezolid; D017576:Daptomycin