There's NO stopping NsrR, a global regulator of the bacterial NO stress response.
Nitric oxide (NO) is a toxic, free radical gas with diverse biological roles in eukaryotes and bacteria, being involved in signalling, vasodilation, blood clotting and immunity and as an intermediate in microbial denitrification. Several bacterial transcriptional regulators sense this molecule and regulate the expression of genes involved in both NO detoxification and NO damage repair. However, a recently discovered NO sensing repressor, named NsrR, has gained attention because of its suggested role as a global regulator of the bacterial NO stress response. Recent advances in biochemical and transcriptomic studies of NsrR make it timely to review the current evidence for NsrR as a global regulator and to speculate on the recent controversy over its NO sensing mechanism.
Tucker
Nicholas P
NP
Strathclyde Institute of Pharmacy and Biomedical Sciences, Royal College, 204 George Street, University of Strathclyde, Glasgow, Scotland GR1 1XW, UK. nick.tucker@strath.ac.uk
Le Brun
Nick E
NE
Dixon
Ray
R
Hutchings
Matthew I
MI
D000595:Amino Acid Sequence; D001419:Bacteria / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D005809:Genes, Regulator; D008969:Molecular Sequence Data; D009569:Nitric Oxide / Q000378:metabolism*; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment
D001426:Bacterial Proteins; D012097:Repressor Proteins; D009569:Nitric Oxide