title: Simultaneous bedside assessment of global cerebral blood flow and effective cerebral perfusion pressure in patients with intracranial hypertension.
abstract: BACKGROUND
  We examined a bedside technique transcerebral double-indicator dilution (TCID) for global cerebral blood flow (CBF) as well as the concept of effective cerebral perfusion pressure (CPP(eff)) during different treatment options for intracranial hypertension, and compared global CBF and CPP(eff) with simultaneously obtained conventional parameters.
  
  
  METHODS
  Twenty-six patients developing intracranial hypertension in the course of traumatic brain injury or subarachnoid hemorrhage were prospectively analyzed using a combined assessment during elevated ventilation (n = 15) or osmotherapy (hypertonic saline or mannitol). For calculation of global CBF, injections of ice-cold indocyanine green boluses were performed and temperature and dye concentration changes were monitored in the thoracic aorta and the jugular bulb. CBF was then calculated according to the mean transit time principle. Estimation of CCP, the arterial pressure at which cerebral blood flow becomes zero, was performed by synchronized registration of corresponding values of blood flow velocity in the middle cerebral artery and arterial pressure and extrapolation to zero-flow velocity. CPP(eff) was calculated as mean arterial pressure minus critical closing pressure (CPP(eff) = MAP(c) - CCP).
  
  
  RESULTS
  Elevated ventilation causes a decrease in both ICP (P < 0.001) and CBF (P < 0.001). While CPP(conv) increased (P < 0.001), CPP(eff) decreased during this observation (P = 0.002). Administration of osmotherapeutic agents resulted in a decrease of ICP (P < 0.001) and a temporary increase of CBF (P = 0.052). CPP(conv) and CPP(eff) showed no striking difference under osmotherapy.
  
  
  CONCLUSIONS
  TCID allows repeated measurements of global CBF at the bedside. Elevated ventilation lowered and osmotherapy temporarily raised global CBF. In situations of increased vasotonus, CPP(eff) is a better indicator of blood flow changes than conventional CPP.
authors.affiliation: Department of Neurosurgery, University of Geneva Medical Center, Geneva, Switzerland. max.jaegersberg@bluewin.ch
authors.forename: M
authors.initials: M
authors.lastname: Jägersberg
authors.forename: C
authors.initials: C
authors.lastname: Schaller
authors.forename: J
authors.initials: J
authors.lastname: Boström
authors.forename: B
authors.initials: B
authors.lastname: Schatlo
authors.forename: M
authors.initials: M
authors.lastname: Kotowski
authors.forename: C
authors.initials: C
authors.lastname: Thees
mesh_terms: D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation / Q000502:physiology; D004234:Diuretics, Osmotic / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D006985:Hyperventilation / Q000175:diagnosis; D008297:Male; D008353:Mannitol / Q000627:therapeutic use; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D004234:Diuretics, Osmotic; D008353:Mannitol