title: Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in Streptomyces coelicolor.
abstract: A tetR family transcriptional regulatory gene (SCO1712) was identified as a global antibiotic regulatory gene from a Streptomyces interspecies DNA microarray analysis. SCO1712 disruption in Streptomyces coelicolor not only upregulated antibiotic biosynthesis through pathway-specific regulators when a previously identified pleiotropic downregulatory wblA was expressed but also further stimulated antibiotic production in a wblA deletion mutant, implying that SCO1712 might encode a novel antibiotic downregulator.
authors.affiliation: Department of Biological Engineering, Inha University, Incheon, South Korea.
authors.forename: Han-Na
authors.initials: HN
authors.lastname: Lee
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Huang
authors.forename: Jong-Hyuk
authors.initials: JH
authors.lastname: Im
authors.forename: Seon-Hye
authors.initials: SH
authors.lastname: Kim
authors.forename: Jun-Hee
authors.initials: JH
authors.lastname: Noh
authors.forename: Stanley N
authors.initials: SN
authors.lastname: Cohen
authors.forename: Eung-Soo
authors.initials: ES
authors.lastname: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001426:Bacterial Proteins / Q000235:genetics*; D005809:Genes, Regulator; D009154:Mutation; D012097:Repressor Proteins / Q000235:genetics*; D013302:Streptomyces / Q000235:genetics; D048372:Streptomyces coelicolor / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D012097:Repressor Proteins