[Development of hair follicle stem cells related signal transduction in proliferation and differentiation].
OBJECTIVE
To introduce the basic research and clinical potential of the hair follicle stem cells related signal transduction in proliferation and differentiation.


METHODS
The recent original articles about the hair follicle stem cells were extensively reviewed.


RESULTS
Many different signal pathways had been involved in the skin development and self-newals.The hair follicle stem cells could play an important role in the skin self-renewal and regeneration which were modulated by several different signal pathways, which included bone morphogenetic protein/transforming growth factor beta, Wnt, Notch and ectodysplasin A genes.


CONCLUSIONS
The hair follicle stem cells may be a future approach to repair cutaneous wounds as a cell therapy.
Xu
Yongan
Y
Key Laboratory of Wound Repair, First Affiliated Hospital, Chinese PLA General Hospital, Beijing, 100048, P.R. China.
Fu
Xiaobing
X
D002454:Cell Differentiation; D049109:Cell Proliferation; D018859:Hair Follicle / Q000166:cytology* / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction; D013234:Stem Cells / Q000166:cytology* / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism; D014945:Wound Healing
D051153:Wnt Proteins