Exercise increases the angiotensin II effects in isolated portal vein of trained rats.
Training in rats adapts the portal vein to respond vigorously to sympathetic stimuli even when the animal is re-exposed to exercise. Moreover, changes in the exercise-induced effects of angiotensin II, a potent venoconstrictor agonist, in venous beds remain to be investigated. Therefore, the present study aimed to assess the effects of angiotensin II in the portal vein and vena cava from sedentary and trained rats at rest or submitted to an exercise session immediately before organ bath experiments. We found that training or exposure of sedentary animals to a single bout of running exercise does not significantly change the responses of the rat portal vein to angiotensin II. However, the exposure of trained animals to a single bout of running exercise enhanced the response of the rat portal vein to angiotensin II. This enhancement appeared to be territory-specific because it was not observed in the vena cava. Moreover, it was not observed in endothelium-disrupted preparations and in preparations treated with N(omega)-nitro-l-arginine methyl ester hydrochloride, indomethacin, BQ-123 or BQ-788. These data indicate that training causes adaptations in the rat portal vein that respond vigorously to angiotensin II even upon re-exposure to exercise. This increased response to angiotensin II requires an enhancement of the vasocontractile influence of endothelin beyond the influence of nitric oxide and vasodilator prostanoids.
Chies
Agnaldo Bruno
AB
Laboratory of Pharmacology, Faculty of Medicine of Marília, Av. Monte Carmelo, 800, Fragata, 17 519-030, Marília, SP, Brazil. agnaldochies@hotmail.com
de Souza Rossignoli
Patrícia
P
Daniel
Elias Fernando
EF
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011169:Portal Vein / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D000804:Angiotensin II