Amplification of epidermal growth factor receptor gene in renal cell carcinoma.
Expression of epidermal growth factor receptor (EGFR) may be of prognostic value in renal cell cancer (RCC). Gene amplification of EGFR was investigated in a cohort of 315 patients with advanced RCC from a previously reported randomised study. Using fluorescent in situ hybridisation, only 2 patients (0.6%) had gene amplification; therefore gene amplification is of no prognostic value in RCC.
El-Hariry
Iman
I
Oncology Business Unit, GlaxoSmithKline, London UB11 1BT, United Kingdom.
Powles
Thomas
T
Lau
Mike R
MR
Sternberg
Cora N
CN
Ravaud
Alain
A
von der Maase
Hans
H
Zantl
Niko
N
Harper
Peter
P
Rolland
Frédéric
F
Audhuy
Bruno
B
Barthel
Friederike
F
Machiels
Jean-Pascal
JP
Patel
Pina
P
Kreuser
Ernst-Dietrick
ED
Hawkins
Robert E
RE
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002292:Carcinoma, Renal Cell / Q000235:genetics* / Q000378:metabolism; D066246:ErbB Receptors / Q000096:biosynthesis* / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007680:Kidney Neoplasms / Q000235:genetics* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis
D066246:ErbB Receptors