title: Effect of preoperative ibuprofen on the success of the inferior alveolar nerve block in patients with irreversible pulpitis.
abstract: BACKGROUND
  The purpose of this prospective, randomized, double-blind, placebo-controlled study was to determine the effect of the administration of preoperative ibuprofen on the success of the inferior alveolar nerve block (IAN) in patients with irreversible pulpitis.
  
  
  METHODS
  One hundred endodontic emergency patients diagnosed with irreversible pulpitis of a mandibular posterior tooth randomly received, in a double-blind manner, identical capsules of either 800 mg ibuprofen or placebo 45 minutes before the administration of a conventional IAN block. Access was begun 15 minutes after completion of the IAN block, and all patients had profound lip numbness. Success was defined as no or mild pain (visual analogue scale recordings) on access or initial instrumentation.
  
  
  CONCLUSIONS
  The success rate for the IAN block was 41% with ibuprofen and 35% with placebo, with no significant difference (P=.57) between the 2 groups. For mandibular posterior teeth, a dose of 800 mg of ibuprofen given 45 minutes before the administration of the IAN block did not result in a statistically significant increase in anesthetic success in patients with irreversible pulpitis.
authors.forename: Mark
authors.initials: M
authors.lastname: Oleson
authors.forename: Melissa
authors.initials: M
authors.lastname: Drum
authors.forename: Al
authors.initials: A
authors.lastname: Reader
authors.forename: John
authors.initials: J
authors.lastname: Nusstein
authors.forename: Mike
authors.initials: M
authors.lastname: Beck
mesh_terms: D000328:Adult; D000766:Anesthesia, Dental / Q000379:methods*; D000779:Anesthetics, Local / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001641:Bicuspid; D016009:Chi-Square Distribution; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D008334:Mandible; D008340:Mandibular Nerve / Q000187:drug effects; D008963:Molar; D009407:Nerve Block / Q000379:methods*; D011229:Preanesthetic Medication / Q000379:methods; D011292:Premedication / Q000379:methods*; D011446:Prospective Studies; D011671:Pulpitis / Q000601:surgery*; D012390:Root Canal Therapy / Q000379:methods; D018709:Statistics, Nonparametric
chemical_list: D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D008012:Lidocaine; D007052:Ibuprofen