title: Hyaluronidase inhibitors from Takuran, Lycopus lucidus.
abstract: Takuran is a traditional herbal medicine that is produced from the herbal plant Lycopus lucidas TURCZ. (Lamiaceae). Takuran is used as a treatment for diseases in women. From Takuran, four new phenylpropanoids along with 18 known compounds were isolated, and their structures were elucidated by spectroscopic analyses. Five phenylpropanoids isolated from the plant showed hyaluronidase inhibitory activity comparable to that of rosmarinic acid.
authors.affiliation: Department of Pharmacognosy, Tohoku Pharmaceutical University, Sendai 981-8558,Japan. murata-t@tohoku-pharm.ac.jp
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Murata
authors.forename: Mai
authors.initials: M
authors.lastname: Watahiki
authors.forename: Yu
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Toshio
authors.initials: T
authors.lastname: Miyase
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Yoshizaki
mesh_terms: D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D053630:Depsides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors / Q000378:metabolism; D019686:Lamiaceae / Q000737:chemistry*; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013045:Species Specificity; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D000097123:Rosmarinic Acid
chemical_list: D002934:Cinnamates; D053630:Depsides; D004365:Drugs, Chinese Herbal; D004791:Enzyme Inhibitors; D006821:Hyaluronoglucosaminidase; D010636:Phenols; D000097123:Rosmarinic Acid