Nanostructured lipid carriers (NLC) on the basis of Siberian pine (Pinus sibirica) seed oil.
Nanostructured lipid carriers (NLC) are new drug systems composed of physiological lipid materials. The possibility of including different types of lipids into the NLC structure revealed the wide prospects for using biologically active natural oils for the development of the cutaneous preparations. In this study the formulation parameters of NLC on the basis of Siberian pine seed oil were evaluated including concentration of lipids, types of surfactants and storage conditions (4 degrees C, 20 degrees C, 40 degrees C). Size distribution and storage stability of formulations produced by hot high pressure homogenisation were investigated by laser diffractometry and photon correlation spectroscopy. The NLC were characterised by their melting behaviour using differential scanning calorimetry. The obtained data indicated the high physical stability of the developed NLC formulations.
Averina
E S
ES
Baikal Institute of Nature Management, Siberian Branch of Russian Academy of Science, Ulan-Ude, Russia. lrad@binm.bscnet.ru
Seewald
G
G
Müller
R H
RH
Radnaeva
L D
LD
Popov
D V
DV
D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D004356:Drug Storage; D005227:Fatty Acids / Q000737:chemistry; D008055:Lipids / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D028223:Pinus / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry*; D020442:Poloxamer; D013501:Surface-Active Agents
D004337:Drug Carriers; D005227:Fatty Acids; D008055:Lipids; D010938:Plant Oils; D013501:Surface-Active Agents; D020442:Poloxamer