The eye imaginal disc as a model to study the coordination of neuronal and glial development.
A complex nervous system comprises two distinct cell types, neurons and glial cells, whose development, differentiation and function is mutually interdependent. Many studies contributed to uncovering the basic mechanisms determining neuronal and glial fate and we are progressing enormously towards an understanding of how neurons interconnect to form intricate neuronal networks. However, the mechanisms used to couple neuronal and glial development remain largely obscure. Here we advocate the usefulness of the developing Drosophila compound eye as a new model to study the complex relationship between glial and neuronal cells.
Silies
Marion
M
Institut für Neurobiologie, Westfälische Wilhelms Universität, Münster, Germany.
Yuva-Aydemir
Yeliz
Y
Franzdóttir
Sigrídur Rut
SR
Klämbt
Christian
C
D000818:Animals; D002465:Cell Movement; D054910:Compound Eye, Arthropod / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D004330:Drosophila / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D055495:Neurogenesis; D009457:Neuroglia / Q000166:cytology / Q000502:physiology; D017468:Receptors, Fibroblast Growth Factor / Q000378:metabolism; D015398:Signal Transduction
D017468:Receptors, Fibroblast Growth Factor