The challenge of Chagas' disease: has the human pathogen, Trypanosoma cruzi, learned how to modulate signaling events to subvert host cells?
Chagas' disease, caused by Trypanosoma cruzi, is an urgent and highly prevalent danger that is endemic to Latin America, and which the research community continues to ignore. Each year, Chagas' disease kills more people in Latin America compared to any other parasite-borne disease, including malaria. In addition, between 15 and 18 million people worldwide are afflicted with this potentially lethal disease. Despite these devastating numbers, less than 0.5% of worldwide research and development for neglected diseases was aimed at Chagas' disease. The aim of this review is to draw the attention of biotechnologists to the intriguing parasite that causes Chagas' disease, which is T. cruzi. Additionally, we would also like to convince the community that basic science research can have a profound impact on the diagnosis and treatment of Chagas' disease. In this review, we introduce distinct features of T. cruzi such as its complex life cycle (e.g. the potentially infective extracellular amastigote form), its genome and genomics, as well as proteomic analysis of this parasite. Notably, the PIK pathway has been widely acknowledged as an excellent target for drug discovery to combat this pathogen. Furthermore we also describe how the identification and characterization of PIK genes can aid in neutralizing Trypanosoma infections.
Lima
F M
FM
Departamento de Microbiologia, Imunologia e Parasitologia, Escola Paulista de Medicina, UNIFESP, São Paulo, SP, Brazil.
Oliveira
P
P
Mortara
R A
RA
Silveira
J F
JF
Bahia
D
D
D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy / Q000469:parasitology*; D055808:Drug Discovery; D006801:Humans; D007303:Insect Vectors / Q000469:parasitology / Q000502:physiology; D008018:Life Cycle Stages / Q000502:physiology; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism; D015800:Protozoan Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014349:Trypanosoma cruzi / Q000235:genetics / Q000472:pathogenicity* / Q000502:physiology*
D015800:Protozoan Proteins; D017853:Phosphotransferases (Alcohol Group Acceptor)