title: A convenient strategy for the annulation of aryl scaffold to A/B-ring steroids under microwave irradiation.
abstract: A facile strategy for the annulation of 2,6-dicyanoaniline moiety to steroidal A/B-ring is described from base catalyzed and microwave-promoted reaction of steroidal 3-keto-2-hydroxymethylenes with malononitrile in high yields. The generality of the reaction has been extended to non-steroidal cyclic and aliphatic ketohydroxylmethylenes.
authors.affiliation: Medicinal Chemistry Division, North-East Institute of Science and Technology (CSIR), Jorhat, Assam 785006, India.
authors.forename: Madan G
authors.initials: MG
authors.lastname: Barthakur
authors.forename: Abdul
authors.initials: A
authors.lastname: Hasib
authors.forename: Junali
authors.initials: J
authors.lastname: Gogoi
authors.forename: Romesh C
authors.initials: RC
authors.lastname: Boruah
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D013256:Steroids / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D013256:Steroids