Structure and absolute configuration of a diterpenoid from Castanea mollissima.
From the nuts of Castanea mollissima Blume, a new kauranoid diterpene glycoside, named mollioside (1), was isolated. Its structure was established as (4R, 5S, 6R, 8R, 9S, 10S, 13R, 16R) 17-O-beta-D-glucopyranoside, ent-6,7-epoxy-6alpha-hydroxyl-6,7-secokaur-19-oic acid, 6, 19-lactone-16beta, 17-diol on the basis of HR-FAB-MS, 1D, 2D-NMR and CD spectral analysis. The aglycone (1a, named mollissin), also as a new compound, was obtained after enzymatic hydrolysis of 1. Both compounds exhibited significant growth inhibitory activity on HeLa tumor cells, but no activity on A375-S2.
Gao
Hui-Yuan
HY
School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, No.103, Wenhua Road, Shenhe District, Shenyang City, People's Republic of China, 110016.
Wang
Xiao-Bo
XB
Xi
Rong-Gang
RG
Sun
Bo-Hang
BH
Huang
Jian
J
Wu
Li-Jun
LJ
D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis; D004224:Diterpenes / Q000302:isolation & purification*; D045786:Diterpenes, Kaurane / Q000302:isolation & purification*; D029962:Fagaceae / Q000737:chemistry*; D005960:Glucosides / Q000302:isolation & purification*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D009754:Nuts / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045786:Diterpenes, Kaurane; D005960:Glucosides; C548383:mollioside