title: Bone mineral density in Swedish otters (Lutra lutra) in relation to PCB and DDE concentrations.
abstract: The aim of this study is to elucidate if DDE (dichlorodiphenyldichloroethylene) or PCB (polybrominated diphenyls), are responsible for the pathological alterations observed in Swedish otter bone tissues. Femurs from 86 male otters collected between 1832 and 2004 were measured using peripheral quantitative computed tomography (pQCT). Some otters had very high and others fairly low concentrations of OCs (ranging between 1.4-970 mg SigmaPCB/kg l.w. and 0.0-24 mg DDE/kg l.w. in muscle tissue). Positive relationships were found between three of the four cortical bone variables analysed (area, content and thickness) and SigmaPCB concentration, while no significant relationships with DDE concentration were found. None of the trabecular variables were significantly related to PCB or DDE concentration. Three of the four trabecular bone variables showed decreasing values in the beginning and increasing values at the end of period 1974-2004. No temporal trends were found for cortical bone variables. OC concentrations decreased between 1974 and 2004.
authors.affiliation: Department of Contaminant Research, Swedish Museum of Natural History, PO Box 50007, SE-104 05 Stockholm, Sweden. anna.roos@nrm.se
authors.forename: Anna
authors.initials: A
authors.lastname: Roos
authors.forename: Frank
authors.initials: F
authors.lastname: Rigét
authors.forename: Jan
authors.initials: J
authors.lastname: Orberg
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D003633:Dichlorodiphenyl Dichloroethylene / Q000378:metabolism / Q000633:toxicity*; D004785:Environmental Pollutants / Q000378:metabolism / Q000633:toxicity*; D005269:Femur / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D010041:Otters / Q000378:metabolism / Q000502:physiology*; D011078:Polychlorinated Biphenyls / Q000378:metabolism / Q000633:toxicity*
chemical_list: D004785:Environmental Pollutants; D003633:Dichlorodiphenyl Dichloroethylene; D011078:Polychlorinated Biphenyls