title: [Research advances on regulation of Pseudomonas aeruginosa biofilm formation and its therapeutic strategies].
abstract: Pseudomonas aeruginosa is an important pathogenic bacterium of nosocomial infections. The microbe easily produce biofilm which brings us much difficulties in clinical treatment. The formation processes of biofilm, including the stages of early bacteria planting, mushroom-like structure forming and extracellular matrix producing, are regulated by a series of molecules and genes. And quorum sensing system of the microbe is responsible for regulation of the whole process of biofilm formation. According to the process of biofilm formation and the mimitat associated regulation mechanism, several anti-biofilm therapeutic strategies have been applied in clinical medicine, and some novel drugs and methods are developed.
authors.affiliation: Department of Respiratory Medicine, Institute of Respiratory Diseases, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Wen-min
authors.initials: WM
authors.lastname: Wang
authors.forename: Zhi-hao
authors.initials: ZH
authors.lastname: Xu
mesh_terms: D018441:Biofilms / Q000254:growth & development*; D015964:Gene Expression Regulation, Bacterial; D011135:Polysaccharides, Bacterial / Q000378:metabolism; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000502:physiology*; D053038:Quorum Sensing / Q000235:genetics* / Q000502:physiology
chemical_list: D011135:Polysaccharides, Bacterial