title: A novel technique combining platelet gel, skin graft, and fibrin glue for healing recalcitrant lower extremity ulcers.
abstract: BACKGROUND
  There is no ideal procedure for the treatment of chronic skin ulcers. The use of platelet gel (PG) in this indication is raising interest.
  
  
  OBJECTIVE
  To evaluate the safety and efficacy of a new procedure combining allogeneic single-donor PG and fibrin glue (FG) to enhance skin graft take for treating recalcitrant ulcers.
  
  
  METHODS
  Fifteen patients with 17 ulcers of various etiologies were enrolled. Skin ulcers were débrided, and the wounds covered with moist saline dressing. Three to 14 days later, the wound bed was sprayed with PG, a thin split-thickness skin graft with multiple slits was put on the wound bed, and FG was sprayed on the skin graft. A short leg polypropylene splint was used to immobilize the skin graft.
  
  
  RESULTS
  Most skin grafts took well. The interval between skin graft and complete wound healing ranged from 3 weeks to 2 months. No recurrence of ulcers was noted during the 3- to 18-month follow-up period. No adverse reactions were observed.
  
  
  CONCLUSIONS
  The procedure provides advantages in skin grafting for recalcitrant ulcers because PG functions as a delivery system of powerful mitogenic and chemostatic factors and FG as a hemostatic tissue sealant that avoids the use of staples or sutures.
authors.affiliation: Division of Plastic Surgery, Department of Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Tim Mo
authors.initials: TM
authors.lastname: Chen
authors.forename: Jui-Che
authors.initials: JC
authors.lastname: Tsai
authors.forename: Thierry
authors.initials: T
authors.lastname: Burnouf
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D062109:Dermatologic Surgical Procedures; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage; D005782:Gels; D006085:Graft Survival; D006801:Humans; D007871:Leg Ulcer / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D017713:Platelet Transfusion / Q000379:methods*; D053657:Platelet-Rich Plasma; D011446:Prospective Studies; D019651:Plastic Surgery Procedures / Q000379:methods*; D016038:Skin Transplantation / Q000379:methods*; D014945:Wound Healing
chemical_list: D015718:Fibrin Tissue Adhesive; D005782:Gels