Asphorodin, a potent lipoxygenase inhibitory triterpene diglycoside from Asphodelus tenuifolius.
Asphorodin (1), a new diglycoside, has been isolated from the ethyl acetate-soluble fraction of Asphodelus tenuifolius. It showed significant inhibitory activity against the enzyme lipoxygenase in a concentration-dependent manner. The Lineweaver-Burk and Dixon plots indicated that the nature of inhibition was non-competitive.
Safder
Muhammad
M
International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, Pakistan.
Imran
Muhammad
M
Mehmood
Rashad
R
Malik
Abdul
A
Afza
Nighat
N
Iqbal
Lubna
L
Latif
Mehreen
M
D004305:Dose-Response Relationship, Drug; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019668:Liliaceae / Q000737:chemistry*; D016859:Lipoxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D010154:Pakistan; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D006027:Glycosides; D016859:Lipoxygenase Inhibitors; D014315:Triterpenes; C547977:asphorodin