Changes of lidocaine levels in rat serum and tissue under stress and hyperlipidaemic diets.
Hyperlipidaemic diets induce increase in serum lipid profile (total cholesterol, triglycerides, LDL etc). It has also been proven that stress interferes in lipid metabolism. Many drugs modify their pharmacokinetic properties in presence of lipoproteins, as a result of alterations in their plasma protein and tissue binding. Lidocaine, a synthetic amide, used as a local anesthetic and secondary as antiarrhythmic agent is also protein bound and therefore conditions, which favor lidocaine dissociation from plasma proteins, modify its pharmacokinetic profile. The purpose of this study was: To investigate and compare the effects of stress( cold water 4 degrees C swimming of 20 days duration) and various high lipid diets (olive oil, butter, sunflower oil) on the serum and tissue (liver and tongue) levels of 14C lidocaine.
Karakitsos
Dimitrios
D
Department of Intensive Care Unit, General State Hospital of Athens, Athens, Hellas.
Karabinis
Andreas
A
Kotsiou
Antonia
A
D000779:Anesthetics, Local / Q000493:pharmacokinetics*; D000818:Animals; D002079:Butter; D004041:Dietary Fats; D008012:Lidocaine / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism; D008297:Male; D000069463:Olive Oil; D010938:Plant Oils / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological; D000074242:Sunflower Oil; D014018:Tissue Distribution; D014059:Tongue / Q000378:metabolism
D000779:Anesthetics, Local; D004041:Dietary Fats; D000069463:Olive Oil; D010938:Plant Oils; D000074242:Sunflower Oil; D002079:Butter; D008012:Lidocaine