title: Schinalactone A, a new cytotoxic triterpenoid from Schisandra sphenanthera.
abstract: A new cytotoxic triterpenoid, schinalactone A (1), together with two new biogenetically related compounds, schinalactones B (2) and C (3), has been isolated from the roots and stems of Schisandra sphenanthera.Their structures were elucidated on the basis of extensive spectroscopic analysis. Compounds 1 and 2 showed significant cytotoxicity against PANC-1 cell lines with IC(50) values of 5.9 and 4.1 microM, respectively. A plausible biosynthetic pathway of 1 was also postulated.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PR China.
authors.forename: Fei
authors.initials: F
authors.lastname: He
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Sheng-Xiong
authors.initials: SX
authors.lastname: Huang
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Wang
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Li-Mei
authors.initials: LM
authors.lastname: Li
authors.forename: Jing-Ping
authors.initials: JP
authors.lastname: Liu
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D008968:Molecular Conformation; D018517:Plant Roots / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D032141:Schisandra / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C549988:schinalactone A; C549989:schinalactone B; C549990:schinalactone C