title: [Specific antisepsis and environmental disinfection in preventing "Clostridium difficile associated diarrhea"].
abstract: In the last years, Clostridium difficile acquired great interest for public health because of constant increase of Clostridium difficile associated diarrhea (CDAD), especially in nosocomial field and as a consequences of its pathogenicity and virulence. Oro-faecal transmission and great environmental persistence of Clostridium difficile indicate hand hygiene of health care workers and environmental disinfection practices as key interventions for prevention and control of nosocomial CDAD. The current indications relative to the hand hygiene suggest the use of soap and water for hand washing and, to achieve a better compliance of health care workers to this treatment, the alternative use of sodium dichloroisocyanurate or alcohol-based solution or gel waterless. Regard to environmental disinfection, to avoid high concentrations of sodium hypochlorite (in the magnitude of 5.000-6.000 ppm), necessary to reduce microbic load of dirty environment, the most appropriate treatment should consist of 2 phases: preliminary cleaning with water and detergents or polyphenol, followed by treatment with solution containing 1.000 ppm available chlorine, obtained from sodium hypochlorite or sodium dichloroisocyanurate.
authors.affiliation: Dipartimento di Scienze Biomediche, Farmacologia, Università di Trieste, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Agolini
authors.forename: C
authors.initials: C
authors.lastname: Protano
authors.forename: V
authors.initials: V
authors.lastname: Puro
authors.forename: A
authors.initials: A
authors.lastname: Raitano
authors.forename: F
authors.initials: F
authors.lastname: Ferraro
authors.forename: M
authors.initials: M
authors.lastname: Vitali
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage; D000985:Antisepsis / Q000379:methods; D016360:Clostridioides difficile; D003428:Cross Infection / Q000453:epidemiology / Q000517:prevention & control*; D004202:Disinfectants / Q000008:administration & dosage; D004203:Disinfection / Q000379:methods; D004761:Enterocolitis, Pseudomembranous / Q000453:epidemiology / Q000517:prevention & control*; D006235:Hand Disinfection; D006801:Humans; D007231:Infant, Newborn; D012973:Sodium Hypochlorite / Q000008:administration & dosage
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D004202:Disinfectants; D012973:Sodium Hypochlorite