title: Radiation-associated liver injury.
abstract: The liver is a critically important organ that has numerous functions including the production of bile, metabolism of ingested nutrients, elimination of many waste products, glycogen storage, and plasma protein synthesis. The liver is often incidentally irradiated during radiation therapy (RT) for tumors in the upper- abdomen, right lower lung, distal esophagus, or during whole abdomen or whole body RT. This article describes the endpoints, time-course, and dose-volume effect of radiation on the liver.
authors.affiliation: Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109-5010, USA. cpan@umich.edu
authors.forename: Charlie C
authors.initials: CC
authors.lastname: Pan
authors.forename: Brian D
authors.initials: BD
authors.lastname: Kavanagh
authors.forename: Laura A
authors.initials: LA
authors.lastname: Dawson
authors.forename: X Allen
authors.initials: XA
authors.lastname: Li
authors.forename: Shiva K
authors.initials: SK
authors.lastname: Das
authors.forename: Moyed
authors.initials: M
authors.lastname: Miften
authors.forename: Randall K
authors.initials: RK
authors.lastname: Ten Haken
mesh_terms: D006801:Humans; D008099:Liver / Q000528:radiation effects*; D008113:Liver Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D008954:Models, Biological; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000150:complications* / Q000628:therapy; D011836:Radiation Tolerance; D012306:Risk