title: Catalytic enantioselective conjugate additions with α,β-unsaturated sulfones.
abstract: We describe the development of a highly efficient catalytic asymmetric conjugate addition to α,β-unsaturated sulfones. Utilizing practical bifunctional organic catalysts and involving air- and moisture-tolerant conditions, conjugate additions of a wide range of Michael donors to α,β-unsaturated sulfones proceeded in excellent enantioselectivity/diastereoselectivity and high yield. This efficient and operationally simple new catalytic asymmetric reaction should provide a versatile approach for the asymmetric synthesis of chiral sulfones bearing all-carbon quaternary stereocenters.
authors.affiliation: Department of Chemistry, Brandeis University, Waltham, Massachuesttes, 02454-9110, USA.
authors.forename: Hongming
authors.initials: H
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Song
authors.forename: Li
authors.initials: L
authors.lastname: Deng