C1q nephropathy in the pediatric population: pathology and pathogenesis.
C1q nephropathy was originally described nearly 25 years ago by Jennette and Hipp. Since that time there have been a limited number of publications on C1q nephropathy, most of them in the pediatric literature. Despite reported incidences as high as 16% in some pediatric biopsy series, a consensus definition on the diagnosis of C1q nephropathy is lacking and its existence as a distinct clinical disease entity remains controversial. The purpose of this review is to discuss the biology of C1q in the context of mechanisms of C1q deposition, and to provide a detailed analysis of the published pediatric case series with a focus on the pathological criteria used to establish the diagnosis of C1q nephropathy as well as long-term outcomes in children.
Wenderfer
Scott E
SE
Division of Pediatric Nephrology and Hypertension, Department of Pediatrics, University of Texas School of Medicine, Houston, USA.
Swinford
Rita D
RD
Braun
Michael C
MC
D001706:Biopsy; D002648:Child; D002908:Chronic Disease; D005921:Glomerulonephritis / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology*; D044382:Population Groups