Neurotoxic manifestations of an overdose intrathecal injection of gadopentetate dimeglumine.
The intravenous administration of gadopentetate dimeglumine (GD) is relatively safe and rarely causes systemic toxicity in the course of routine imaging studies. However, the general safety of intrathecal GD has not been established. We report a very rare case of an overdose intrathecal GD injection presenting with neurotoxic manifestations, including a decreased level of consciousness, global aphasia, rigidity, and visual disturbance.
Park
Kwan-Woong
KW
Department of Neurosurgery, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
Im
Soo-Bin
SB
Kim
Bum-Tae
BT
Hwang
Sun-Chul
SC
Park
Jong-Sun
JS
Shin
Won-Han
WH
D000328:Adult; D001037:Aphasia / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000187:drug effects / Q000473:pathology; D003287:Contrast Media / Q000008:administration & dosage / Q000633:toxicity; D019786:Gadolinium DTPA / Q000008:administration & dosage / Q000633:toxicity; D006801:Humans; D007278:Injections, Spinal; D008297:Male; D009127:Muscle Rigidity / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D020258:Neurotoxicity Syndromes / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D014057:Tomography, X-Ray Computed; D014786:Vision Disorders / Q000209:etiology / Q000473:pathology
D003287:Contrast Media; D019786:Gadolinium DTPA