Synthesis of ansa1-cytidines.
The synthesis of new ansa(1)-N(4)5-ethylene cytidines such as 3-ss-D-ribofuranosyl-3,5,6,7-tetrahydro-2H-pyrrolo[2,3-d]pyrimidin-2-one is described and the problems connected with the ring closure to the desired tetrahydro-2H-pyrrolo[2,3-d]pyrimidine base discussed. The lack of biological activities of the new ansa(1-) cytidines is furthermore commented on.
Krolikiewicz
Konrad
K
Medicinal Chemistry, The former Schering AG, now Bayer Schering Pharma AG, Berlin, Germany.
Schäfer
Martina
M
Vorbrüggen
Helmut
H
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D003562:Cytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008958:Models, Molecular
D000970:Antineoplastic Agents; D003562:Cytidine