Markers of oxidative damage are not elevated in otherwise healthy individuals with the metabolic syndrome.
OBJECTIVE
The role of oxidative damage in the pathogenesis of metabolic syndrome is poorly understood.


METHODS
A detailed cross-sectional study was performed to assess the relationship between lipid oxidation products, gamma-glutamyltransferase, high-sensitivity C-reactive protein (hs-CRP), and phospholipase activities with respect to the metabolic status in a cohort of otherwise healthy individuals.


RESULTS
A total of 179 individuals (87 men and 92 women) aged 43 +/- 14 years (mean +/- SD) participated in this study. There were no differences in the levels of plasma F(2)-isoprostanes, hydroxyeicosatetraenoic acids, cholesterol oxidation products, and phospholipase activities in individuals with features of metabolic syndrome. In multivariate analyses, serum hs-CRP was a consistent independent predictor of metabolic syndrome.


CONCLUSIONS
Minimal changes were observed in multiple markers of oxidative damage in a well-characterized cohort of individuals with features of metabolic syndrome.
Seet
Raymond C-S
RC
Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. raymond_seet@nus.edu.sg
Lee
Chung-Yung J
CY
Lim
Erle C H
EC
Quek
Amy M L
AM
Huang
Shan-Hong
SH
Khoo
Chin-Meng
CM
Halliwell
Barry
B
D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis / Q000378:metabolism*; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D054467:Phospholipases A2 / Q000097:blood; D011237:Predictive Value of Tests; D005723:gamma-Glutamyltransferase / Q000097:blood
D015415:Biomarkers; D002097:C-Reactive Protein; D005723:gamma-Glutamyltransferase; D054467:Phospholipases A2