title: Mechanisms of estrogen-induced venous thromboembolism.
abstract: The use of oral contraceptives (OC) is a well established risk factor for venous thrombosis. It has been known for many years that almost all haemostatic parameters i.e. plasma levels of coagulation factors, anticoagulant proteins and proteins involved in the fibrinolytic pathway change during OC use. The discovery of several risk factors of venous thrombosis in the 1990s shed new light on the association between the effects of OC on the haemostatic system and the increased risk of venous thrombosis. In this review, we summarize the current knowledge on the effects of different kinds of hormonal contraceptives (OC, transdermal contraceptives, vaginal ring and levonorgestrel-releasing intrauterine device) on haemostatic variables and the relationship between the changes of these variables and the risk of venous thrombosis.
authors.affiliation: Department of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
authors.forename: Svetlana N
authors.initials: SN
authors.lastname: Tchaikovski
authors.forename: Jan
authors.initials: J
authors.lastname: Rosing
mesh_terms: D001779:Blood Coagulation Factors / Q000494:pharmacology; D003267:Contraception; D003270:Contraceptive Agents / Q000494:pharmacology; D003276:Contraceptives, Oral / Q000009:adverse effects* / Q000494:pharmacology; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D016912:Levonorgestrel / Q000494:pharmacology; D012306:Risk; D012307:Risk Factors; D054556:Venous Thromboembolism; D020246:Venous Thrombosis / Q000139:chemically induced
chemical_list: D001779:Blood Coagulation Factors; D003270:Contraceptive Agents; D003276:Contraceptives, Oral; D004967:Estrogens; D016912:Levonorgestrel