title: Antiplasmodial procyanidins derivatives from Chinese Hawthorn.
abstract: The methanolic extract of the leaves of Chinese Hawthorn was investigated for its activity against chloroquine-sensitive strains of Plasmodium falciparum using the method of parasite lactate dehydrogenase assay. Four oligomeric procyanidins, such as epicatechin-(4β→8)-epicatechin-(4β→8)-epicatechin (1), epicatechin-(4β→8)-epicatechin-(4β→6)-epicatechin (2), epicatechin-(4β→6)-epicatechin-(4β→8)-epicatechin (3), and epicatechin-(4β→8)-epicatechin-(4β→8)-epicatechin-(4β→8)-epicatechin-(4β→8) (4), were isolated and evaluated for in vitro antiplasmodial activity, as well as for their cytotoxic potential on SK-OV-3 cancer cell lines. Three procyanidins showed notable growth inhibitory activity against chloroquine-sensitive strains of P. falciparum with IC(50) values of 2.7 μM (SI values of >55.5). The compounds showed no significant cytotoxicity (IC(50) > 150 μM) toward the SK-OV-3 cancer cell line. This is the first report on the antiplasmodial activity of these oligomeric procyanidins from Chinese Hawthorn.
authors.affiliation: Division of Environmental and Resource, College of Environmental and Bioresource Sciences, Chonbuk National University, Iksan, South Korea.
authors.forename: Yool-Jin
authors.initials: YJ
authors.lastname: Park
authors.forename: Ill-Min
authors.initials: IM
authors.lastname: Chung
authors.forename: Hyung-In
authors.initials: HI
authors.lastname: Moon
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D027825:Crataegus / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D000432:Methanol / Q000737:chemistry; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects*; D044945:Proanthocyanidins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000962:Antimalarials; D004365:Drugs, Chinese Herbal; D044945:Proanthocyanidins; D002392:Catechin; D000432:Methanol