title: Total synthesis of caminoside B, a novel antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia.
abstract: The first total synthesis of caminoside B, a novel marine antimicrobial glycolipid isolated from the marine sponge Caminus sphaeroconia, was developed. This marine small molecule inhibitor (IC(50)=20 microM) targeting type III secretory pathway of bacterial pathogenesis was assembled in good yield via a '2+2+1' strategy based on stereocontrolled construction of the four glycosidic linkages.
authors.affiliation: School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.
authors.forename: Zaihong
authors.initials: Z
authors.lastname: Zhang
authors.forename: Chengli
authors.initials: C
authors.lastname: Zong
authors.forename: Gaopeng
authors.initials: G
authors.lastname: Song
authors.forename: Guokai
authors.initials: G
authors.lastname: Lv
authors.forename: Yuexing
authors.initials: Y
authors.lastname: Chun
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Ning
authors.initials: N
authors.lastname: Ding
authors.forename: Yingxia
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D006017:Glycolipids / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D006017:Glycolipids; C508811:caminoside B