Spatiotemporal and Spatial Threshold Models for Relating UV Exposures and Skin Cancer in the Central United States.
The exact mechanisms relating exposure to ultraviolet (UV) radiation and elevated risk of skin cancer remain the subject of debate. For example, there is disagreement on whether the main risk factor is duration of the exposure, its intensity, or some combination of both. There is also uncertainty regarding the form of the dose-response curve, with many authors believing only exposures exceeding a given (but unknown) threshold are important. In this paper we explore methods to estimate such thresholds using hierarchical spatial logistic models based on a sample of a cohort of x-ray technologists for whom we have self-reports of time spent in the sun and numbers of blistering sunburns in childhood. A preliminary goal is to explore the temporal pattern of UV exposure and its gradient. Changes here would imply that identical exposure self-reports from different calendar years may correspond to differing cancer risks.
Hatfield
Laura A
LA
Laura A. Hatfield is graduate assistant and Bradley P. Carlin is Mayo Professor in Public Health in the Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 55455. Richard W. Hoffbeck is Research Associate and Bruce H. Alexander is Associate Professor in the Division of Environmental Health, School of Public Health, University of Minnesota, Minneapolis, MN, 55455.
Hoffbeck
Richard W
RW
Alexander
Bruce H
BH
Carlin
Bradley P
BP