Leiomyosarcoma arising in a patient with prior mitotically active leiomyoma.
Mitotically active leiomyomas exhibiting insignificant cytologic atypia (none to mild) with an increased mitotic count of 5-20 mitotic figures per 10 high power fields, and without coagulative tumor cell necrosis or atypical mitoses, tend to have a benign clinical course. We encountered a case of a mitotically active leiomyoma and malignant transformation after a total hysterectomy. The recurrent multiple abdominal masses were removed surgically; most of them were benign leiomyomas, but some were leiomyosarcomas. Although most mitotically active leiomyomas have a benign clinical course, these lesions can recur and have the potential for malignant transformation. Therefore, patients with mitotically active leiomyomas require close follow-up.
Kim
Jin Hwi
JH
Department of Obstetrics and Gynecology, Catholic University, Seoul, Korea. kjh@catholic.ac.kr
Choi
Young Jin
YJ
Kim
Dong Chul
DC
Lee
Sung Jong
SJ
D000008:Abdominal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D000368:Aged; D002471:Cell Transformation, Neoplastic; D003110:Colonic Neoplasms / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000473:pathology* / Q000601:surgery; D007890:Leiomyosarcoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008940:Mitotic Index; D016609:Neoplasms, Second Primary / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D011859:Radiography; D014594:Uterine Neoplasms / Q000473:pathology* / Q000601:surgery