title: Ultrasmall particle of iron oxide--RGD peptidomimetic conjugate: synthesis and characterisation.
abstract: Ultrasmall particles of iron oxide (USPIOs) coated with 3,3'-bis(phosphonate)propionic acid were covalently coupled to a home-made Arg-Gly-Asp (RGD) peptidomimetic molecule via a short oligoethylene-glycol (OEG) spacer. The conjugation rate was measured by X-ray photoelectron spectroscopy (XPS). The particle size and magnetic characteristics were kept. Our novel conjugate targeted efficiently Jurkat cells (increase of 229% vs the control).
authors.affiliation: Unité de Chimie Organique et Médicinale, Université Catholique de Louvain, Bâtiment Lavoisier, Louvain-la-Neuve, Belgium.
authors.forename: Vincent
authors.initials: V
authors.lastname: Rerat
authors.forename: Sophie
authors.initials: S
authors.lastname: Laurent
authors.forename: Carmen
authors.initials: C
authors.lastname: Burtéa
authors.forename: Benoît
authors.initials: B
authors.lastname: Driesschaert
authors.forename: Vincent
authors.initials: V
authors.lastname: Pourcelle
authors.forename: Luce
authors.initials: L
authors.lastname: Vander Elst
authors.forename: Robert N
authors.initials: RN
authors.lastname: Muller
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Marchand-Brynaert
mesh_terms: D005290:Ferric Compounds / Q000737:chemistry*; D018716:Molecular Mimicry; D009842:Oligopeptides / Q000737:chemistry*; D010316:Particle Size; D013057:Spectrum Analysis / Q000379:methods; D014965:X-Rays
chemical_list: D005290:Ferric Compounds; D009842:Oligopeptides; C000499:ferric oxide; C047981:arginyl-glycyl-aspartic acid