title: Further evidence for direct pro-resorptive actions of FSH.
abstract: We confirm that FSH stimulates osteoclast formation, function and survival to enhance bone resorption. It does so via the activation of a pertussis toxin-sensitive G(i)-coupled FSH receptor that we and others have identified on murine and human osteoclast precursors and mature osteoclasts. FSH additionally enhances the production of several osteoclastogenic cytokines, importantly TNFalpha, likely within the bone marrow microenvironment, to augment its pro-resorptive action. FSH levels in humans rise before estrogen falls, and this hormonal change coincides with the most rapid rates of bone loss. On the basis of accumulating evidence, we reaffirm that FSH contributes to the rapid peri-menopausal and early post-menopausal bone loss, which might thus be amenable to FSH blockade.
authors.affiliation: Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Zhang
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Zhu
authors.forename: Yuanzhen
authors.initials: Y
authors.lastname: Peng
authors.forename: Xuan
authors.initials: X
authors.lastname: Liu
authors.forename: Jianhua
authors.initials: J
authors.lastname: Li
authors.forename: Manasi
authors.initials: M
authors.lastname: Agrawal
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Robinson
authors.forename: Jameel
authors.initials: J
authors.lastname: Iqbal
authors.forename: Harry C
authors.initials: HC
authors.lastname: Blair
authors.forename: Mone
authors.initials: M
authors.lastname: Zaidi
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D002460:Cell Line; D005640:Follicle Stimulating Hormone / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D051379:Mice; D010010:Osteoclasts / Q000378:metabolism* / Q000473:pathology; D011962:Receptors, FSH / Q000378:metabolism
chemical_list: D011962:Receptors, FSH; D005640:Follicle Stimulating Hormone