Electrochemical concentration of no-carrier-added [(18)F]fluoride from [(18)O]water in a disposable microfluidic cell for radiosynthesis of (18)F-labeled radiopharmaceuticals.
The realization of the electrochemical method for microfluidic radiosynthesis is described for concentrating aqueous no-carrier-added [(18)F]fluoride into an aprotic solvent in a disposable microfluidic cell. Flowing aqueous [(18)F]fluoride was introduced into a disposable microfluidic cell (16microL) under an electric potential (10V), followed by anhydrous MeCN. The trapped [(18)F]fluoride was released in MeCN containing Kryptofix 222-KHCO(3) (ca. 60microL) under heat and a reversed potential (-2.5V). An automated module provided the [(18)F]fluoride ready for subsequent microfluidic radiosynthesis in overall radiochemical yields of 60% within 6min.
Saiki
Hidekazu
H
Technology Research Laboratory, Shimadzu Corporation, Kyoto, Japan.
Iwata
Ren
R
Nakanishi
Hiroaki
H
Wong
Rebecca
R
Ishikawa
Yoichi
Y
Furumoto
Shozo
S
Yamahara
Ryo
R
Sakamoto
Katsumasa
K
Ozeki
Eiichi
E
D004209:Disposable Equipment; D004563:Electrochemistry / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D007553:Isotope Labeling / Q000295:instrumentation*; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D010103:Oxygen Isotopes / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000302:isolation & purification*
D005462:Fluorine Radioisotopes; D010103:Oxygen Isotopes; D019275:Radiopharmaceuticals