title: Synthesis of the anti-virus compound shuangkangsu's analogs.
abstract: Four novel cyclic peroxide glucosides 15a, 15b, 16a, and 16b, optically pure analogs of shuangkangsu (1), which is an anti-virus natural product with an unusual skeleton isolated from the buds of Lonicera japonica Thunb, were first synthesized totally in six steps including cycloaddition of furan with diethyl acetylenedicarboxylate and glycosylation.
authors.affiliation: The Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Peking Union Medical College, Ministry of Education, Beijing, China.
authors.forename: Di-Zao
authors.initials: DZ
authors.lastname: Li
authors.forename: Yan-Bo
authors.initials: YB
authors.lastname: Tang
authors.forename: Zhi-Yun
authors.initials: ZY
authors.lastname: Kang
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Chen
authors.forename: De-Quan
authors.initials: DQ
authors.lastname: Yu
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004146:Dioxanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006031:Glycosylation; D031239:Lonicera / Q000737:chemistry*; D015394:Molecular Structure; D009005:Monosaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D009975:Orthomyxoviridae / Q000187:drug effects; D010084:Oxidation-Reduction; D012136:Respiratory Syncytial Viruses / Q000187:drug effects
chemical_list: C539038:5,8-divinyl-1,4-dihydro-1,4-di-O-beta-D-glucopyranosyl-2,3-dioxane; D000998:Antiviral Agents; D004146:Dioxanes; D009005:Monosaccharides