A Mathematical Model for the First-Pass Dynamics of Antibiotics Acting on the Cardiovascular System.
We present a preliminary first-pass dynamic model for delivery of drug compounds to the lungs and heart. We use a compartmental mass balance approach to develop a system of nonlinear differential equations for mass accumulated in the heart as a result of intravenous injection. We discuss sensitivity analysis as well as methodology for minimizing mass in the heart while maximizing mass delivered to the lungs on a first circulatory pass.
Banks
H T
HT
Center for Research in Scientific Computation (Box 8212), North Carolina State University, Raleigh, NC 27695.
Holm
Kathleen
K
Wanner
Nathan C
NC
Cintrón-Arias
Ariel
A
Kepler
Grace M
GM
Wetherington
Jeffrey D
JD