title: An Efficient, Microwave-Assisted, One-Pot Synthesis of Indoles Under Sonogashira Conditions.
abstract: A microwave-assisted, one-pot, three-component coupling reaction for the synthesis of indoles has been developed. The reaction is carried out in two steps under standard Sonogashira coupling conditions from an N-substituted/N,N-disubstituted 2-iodoaniline and a terminal alkyne, followed by the addition of acetonitrile and an aryl iodide. A variety of polysubstituted indoles have been prepared in moderate to excellent yields using the present method.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, IA 50011.
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Nataliya A
authors.initials: NA
authors.lastname: Markina
authors.forename: Richard C
authors.initials: RC
authors.lastname: Larock