Differences in the salivary effects of wild-caught versus colonized Phlebotomus papatasi (Diptera: Psychodidae) on the development of zoonotic cutaneous leishmaniasis in BALB/c mice.
Preimmunization of mice with salivary gland homogenate (SGH) of long-term colonized (F29) female Phlebotomus papatasi Scopoli (Diptera: Psychodidae) induced protection against Leishmania major Yakimoff & Schokhor (Kinetoplastida: Trypanosomatidae) co-inoculated with the same type of SGH. In contrast, preimmunization of mice with SGH of wild-caught female P. papatasi did not confer protection against L. major co-inoculated with the same type of SGH. Similarly, SGH from recently colonized (F1) female P. papatasi did not protect mice against L. major. These results suggest that when developing a sand fly saliva-based vaccine, the natural vector populations should be considered.
Ben Hadj Ahmed
S
S
Laboratory of Vector Ecology, Institut Pasteur de Tunis, 13 Place Pasteur, BP 74, 1002 Tunis, Tunisia.
Chelbi
I
I
Kaabi
B
B
Cherni
S
S
Derbali
M
M
Zhioua
E
E
D000818:Animals; D005260:Female; D016773:Leishmaniasis, Cutaneous / Q000503:physiopathology* / Q000635:transmission; D051379:Mice; D008807:Mice, Inbred BALB C; D010691:Phlebotomus / Q000472:pathogenicity*; D010217:Phlebotomus Fever / Q000635:transmission*; D012469:Salivary Glands / Q000469:parasitology; D015047:Zoonoses / Q000469:parasitology