mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis.
Laplante
Mathieu
M
Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.
Sabatini
David M
DM
D000818:Animals; D005786:Gene Expression Regulation; D005943:Gluconeogenesis / Q000235:genetics*; D007328:Insulin / Q000378:metabolism / Q000494:pharmacology; D007333:Insulin Resistance; D050155:Lipogenesis / Q000235:genetics*; D008099:Liver / Q000378:metabolism; D000076222:Mechanistic Target of Rapamycin Complex 1; D051379:Mice; D023421:Models, Animal; D046912:Multiprotein Complexes; D011506:Proteins; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics*; D058570:TOR Serine-Threonine Kinases; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism*
D007328:Insulin; D046912:Multiprotein Complexes; D011506:Proteins; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases