title: [Rol of pituitary tumour-transforming gene (PTTG) in the pituitary adenomas].
abstract: The pathogenesis of pituitary tumours is far to be understood. Pituitary transforming tumour gene (PTTG), a gen that induces aneuploidy, genetic instability, cellular proliferation and to stimulate angiogenesis, has been involved in neoplasic transformation and shown overexpressed in many neoplasm as lung, breast, endometrium, thyroid and colon malignant tumours. On the other hand, PTTG has been inconsistently studied in pituitary tumours. The majority of studies have been performed in animals and there is a great variability in the methods used in its determination. The goal of this review is to resume the role of PTTG in tumourogenesis and critically to revise the studies published in humans in order to advance in the knowledge of the pathogenesis of pituitary adenomas and to find clinical useful predictors of the behavior of these tumours.
authors.affiliation: Sección de Endocrinología y Nutrición, Hospital General Universitario de Alicante, Alicante, España.
authors.forename: Ruth
authors.initials: R
authors.lastname: Sánchez-Ortiga
authors.forename: Laura
authors.initials: L
authors.lastname: Sánchez Tejada
authors.forename: Gloria
authors.initials: G
authors.lastname: Peiró Cabrera
authors.forename: Oscar
authors.initials: O
authors.lastname: Moreno-Pérez
authors.forename: Nieves
authors.initials: N
authors.lastname: Arias Mendoza
authors.forename: F Ignacio
authors.initials: FI
authors.lastname: Aranda López
authors.forename: Antonio
authors.initials: A
authors.lastname: Picó Alfonso
mesh_terms: D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics*; D010911:Pituitary Neoplasms / Q000235:genetics*; D064249:Securin
chemical_list: D009363:Neoplasm Proteins; D064249:Securin; C578002:pituitary tumor-transforming protein 1, human