title: MRI and S-MRCP findings in patients with suspected chronic pancreatitis: correlation with endoscopic pancreatic function testing (ePFT).
abstract: OBJECTIVE
  To review magnetic resonance imaging (MRI) and secretin stimulated magnetic resonance cholangiopancreatography (S-MRCP) findings of patients with suspected chronic pancreatitis and compare them with endoscopic pancreatic function testing (ePFT).
  
  
  METHODS
  MRI and S-MRCP findings of 36 patients with clinically suspected chronic pancreatitis were reviewed. Baseline ductal changes, duodenal filling grades, and pancreatic duct caliber change (PDC) on S-MRCP, mean values of pancreatic anteroposterior (AP) diameter, signal intensity ratio (SIR) between pancreas and the spleen on T1-weighted fat saturated images, and arterial to venous (A/V) enhancement ratios were compared between groups of normal and abnormal pancreatic exocrine function determined by ePFT.
  
  
  RESULTS
  All patients (n = 24) with normal ePFT (HCO(3) >80 mEq/L) had grade 3 normal duodenal filling. Patients with abnormal ePFT (HCO(3) <80 mEq/L) (n = 12) had grade 1 (n = 1) and grade 2 (n = 11) diminished duodenal filling (P < 0.0001). PDC was 1.51 in the normal ePFT group versus 1.27 in the abnormal ePFT group (P = 0.01). No significant differences were found in terms of mean pancreatic AP diameter (21.8 vs. 19.8 cm), SIR (1.59 vs. 1.44), and A/V (1.08 vs. 1.01) between groups of normal/abnormal pancreatic exocrine function.
  
  
  CONCLUSIONS
  Despite discrepancies between pancreatic exocrine function and the findings on standard MRI/MRCP, the S-MRCP findings are comparable to ePFT in the evaluation of chronic pancreatitis.
authors.affiliation: Department of Radiology, St. Louis, Missouri 63110, USA. ncbalci@gmail.com
authors.forename: N Cem
authors.initials: NC
authors.lastname: Balci
authors.forename: Adam
authors.initials: A
authors.lastname: Smith
authors.forename: Amir Javad
authors.initials: AJ
authors.lastname: Momtahen
authors.forename: Samer
authors.initials: S
authors.lastname: Alkaade
authors.forename: Rana
authors.initials: R
authors.lastname: Fattahi
authors.forename: Syed
authors.initials: S
authors.lastname: Tariq
authors.forename: Frank
authors.initials: F
authors.lastname: Burton
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004724:Endoscopy; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000175:diagnosis*; D015203:Reproducibility of Results; D012633:Secretin; D012680:Sensitivity and Specificity; D013223:Statistics as Topic
chemical_list: D012633:Secretin