Primal RNAs: The end of the beginning?
The amplification of small RNAs and the assembly of heterochromatin are mutually dependent processes in fission yeast. But which comes first? Halic and Moazed (2010) propose that primal small RNAs initiate the amplification of small interfering RNAs that drive heterochromatin formation and chromatin silencing.
Conte
Darryl
D
University of Massachusetts Medical School, Worcester, 01605, USA.
Mello
Craig C
CC
D006570:Heterochromatin / Q000378:metabolism*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism; D022661:RNA, Untranslated / Q000378:metabolism*; D012568:Schizosaccharomyces / Q000235:genetics* / Q000378:metabolism*
D006570:Heterochromatin; D034741:RNA, Small Interfering; D022661:RNA, Untranslated