title: Two new compounds from the dried tender stems of Cinnamomum cassia.
abstract: Two new compounds, cinnamic aldehyde cyclic d-galactitol 3'R,4'S-acetal (1) and cinnamomumolide (2), along with six known compounds, syringaresinol (3), lyoniresinol (4), 5,7,3'-trimethoxyl-( - )-epicatechin (5), 5,7-dimethoxyl-3',4'-di-O-methylene-( +/- )-epicatechin (6), 2-methoxyl-4-hydroxy cinnamyl aldehyde (7), and glucosyringic acid (8), have been isolated from the dried tender stems of Cinnamomum cassia. Their structures were elucidated based on spectroscopic data. Compound 2 was elucidated as 8-methoxyl-9-hydroxy-3',4'-methylenedioxy-3S,4R-diphenyl butyrolactone, named cinnamomumolide, which exhibited activity in protecting against the injury caused by hydrogen peroxide oxidation on human umbilical vein endothelial cells, with an EC(50) value of 10.7 microM. Compounds 3-8 were isolated from the title plant for the first time.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Liu
authors.forename: Shao-Min
authors.initials: SM
authors.lastname: Zhong
authors.forename: Ruo-Yun
authors.initials: RY
authors.lastname: Chen
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Zhu
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000840:Anisoles / Q000302:isolation & purification; D002934:Cinnamates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032904:Cinnamomum aromaticum / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D042783:Endothelial Cells / Q000187:drug effects; D005663:Furans / Q000302:isolation & purification; D004376:Galactitol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D017705:Lignans / Q000302:isolation & purification; D015394:Molecular Structure; D009281:Naphthalenes / Q000302:isolation & purification; D010084:Oxidation-Reduction; D018547:Plant Stems / Q000737:chemistry; D014470:Umbilical Cord / Q000166:cytology / Q000187:drug effects; D014947:Wounds and Injuries / Q000139:chemically induced
chemical_list: D000840:Anisoles; D002934:Cinnamates; D004365:Drugs, Chinese Herbal; D005663:Furans; D017705:Lignans; D009281:Naphthalenes; C548605:cinnamic aldehyde cyclic D-galactitol 3'R,4'S-acetal; C548606:cinnamomumolide; C502379:lyoniresinol; D004376:Galactitol; C042192:syringaresinol; D006861:Hydrogen Peroxide; D015107:4-Butyrolactone