13C-urea breath test for the diagnosis of Helicobacter pylori infection in bleeding duodenal ulcer.
Helicobacter pylori (H. pylori) is the main etiologic factor for duodenal ulcer (DU). Bleeding is still a frequent and sometimes severe complication, with unacceptable mortality despite modern therapeutic modalities. The importance of diagnosing and treating H. pylori infection in bleeding DU is underlined by the fact that eradication therapy is effective in preventing recurrent bleeding. The aim of this study was to evaluate the prevalence of H. pylori infection by means of 13C urea breath test (13C-UBT) in patients with bleeding DU.


METHODS
Thirty-nine patients (25 men, 14 women) hospitalized with bleeding DU underwent emergency endoscopy and treated with intravenous proton pump inhibitors (PPIs), and a 13C-UBT was performed the day after the resuming oral feeding.


RESULTS
Twenty-seven patients (19 men, 8 women) (69.3%) had a positive 13C-UBT. All patients received intravenous PPIs (22 pantoprazole, 17 esomeprazole) after emergency endoscopy (80 mg bolus + 8 mg/hour infusion/day) for 3-4 days. The time elapsed between admission and performance of 13C-UBT did not differ significantly between patients having a positive or negative 3C-UBT (5.6 vs 6.1 days). Eight of the twelve patients (66.6%) with a negative 13C-UBT had a repeated test two month later, and five of them became positive; therefore, H. pylori infection was finally detected in 32 (82%) out of 39 patients with bleeding DU.


CONCLUSIONS
Most patients with bleeding DU have a positive 13C-UBT although they were taking PPIs.
Sfarti
C
C
"Gr.T. Popa" University of Medicine and Pharmacy Iaşi, School of Medicine, Gastroenterology and Hepatology Institute Iaşi.
Stanciu
C
C
Cojocariu
Camelia
C
Trifan
Anca
A
D000328:Adult; D000368:Aged; D001944:Breath Tests / Q000379:methods; D002247:Carbon Isotopes; D004381:Duodenal Ulcer / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D016481:Helicobacter Infections / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010438:Peptic Ulcer Hemorrhage / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D015995:Prevalence; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012189:Retrospective Studies; D012383:Romania / Q000453:epidemiology; D012680:Sensitivity and Specificity; D014508:Urea
D002247:Carbon Isotopes; D054328:Proton Pump Inhibitors; D014508:Urea