Synthesis and chain-dependent antifungal activity of long-chain 2H-azirine-carboxylate esters related to dysidazirine.
Analogues of the antifungal marine natural product (E)-dysidazirine were prepared and evaluated in broth ro-dilution assays against a panel of fungal pathogens. A simple structure-activity relationship was developed which provides insight into the mechanism of action of long-chain 2H-azirine carboxylates.
Skepper
Colin K
CK
Department of Chemistry and Biochemistry, San Diego, La Jolla, CA 92093, USA.
Dalisay
Doralyn S
DS
Molinski
Tadeusz F
TF
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001389:Azirines / Q000737:chemistry*; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D004952:Esters; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D001389:Azirines; D002264:Carboxylic Acids; D004952:Esters; C096952:dysidazirine