title: Bis(thiosemicarbazonato) Cu-64 complexes for positron emission tomography imaging of Alzheimer's disease.
abstract: A bis (thiosemicarbazonato) complex radiolabeled with positron emitting Cu-64 can be used for a new and alternative method for the non-invasive diagnosis of Alzheimer's disease using positron emission tomography (PET). Most imaging agents being investigated for the diagnosis of Alzheimer's disease target amyloid-beta plaque burden but our new approach highlights altered copper homeostasis. This approach has the potential to offer complementary information to other diagnostic procedures that elucidate plaque burden.
authors.affiliation: Department of Pathology, University of Melbourne, Melbourne, Victoria, Australia.
authors.forename: Michelle T
authors.initials: MT
authors.lastname: Fodero-Tavoletti
authors.forename: Victor L
authors.initials: VL
authors.lastname: Villemagne
authors.forename: Brett M
authors.initials: BM
authors.lastname: Paterson
authors.forename: Anthony R
authors.initials: AR
authors.lastname: White
authors.forename: Qiao-Xin
authors.initials: QX
authors.lastname: Li
authors.forename: James
authors.initials: J
authors.lastname: Camakaris
authors.forename: Graeme
authors.initials: G
authors.lastname: O'Keefe
authors.forename: Roberto
authors.initials: R
authors.lastname: Cappai
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Barnham
authors.forename: Paul S
authors.initials: PS
authors.lastname: Donnelly
mesh_terms: D000544:Alzheimer Disease / Q000000981:diagnostic imaging*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging; D001931:Brain Mapping; D003301:Copper Radioisotopes / Q000737:chemistry; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D049268:Positron-Emission Tomography / Q000379:methods*; D053764:Presenilin-1 / Q000235:genetics; D019275:Radiopharmaceuticals / Q000737:chemistry; D014018:Tissue Distribution; D051844:alpha-Synuclein / Q000378:metabolism
chemical_list: D016564:Amyloid beta-Protein Precursor; D003301:Copper Radioisotopes; C508853:PSEN1 protein, human; D053764:Presenilin-1; D019275:Radiopharmaceuticals; D051844:alpha-Synuclein