Radiation dose-volume effects in the lung.
The three-dimensional dose, volume, and outcome data for lung are reviewed in detail. The rate of symptomatic pneumonitis is related to many dosimetric parameters, and there are no evident threshold "tolerance dose-volume" levels. There are strong volume and fractionation effects.
Marks
Lawrence B
LB
Department of Radiation Oncology, University of North Carolina, Chapel Hill, NC 27514, USA. marks@med.unc.edu
Bentzen
Soren M
SM
Deasy
Joseph O
JO
Kong
Feng-Ming Spring
FM
Bradley
Jeffrey D
JD
Vogelius
Ivan S
IS
El Naqa
Issam
I
Hubbs
Jessica L
JL
Lebesque
Joos V
JV
Timmerman
Robert D
RD
Martel
Mary K
MK
Jackson
Andrew
A
D006801:Humans; D008168:Lung / Q000528:radiation effects*; D008175:Lung Neoplasms / Q000473:pathology / Q000532:radiotherapy; D008954:Models, Biological; D015233:Models, Statistical; D017564:Radiation Pneumonitis / Q000209:etiology*; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage