Interdependent biological systems, multi-functional molecules: the evolving role of tissue factor pathway inhibitor beyond anti-coagulation.
Coagulation, innate immunity, angiogenesis, and lipid metabolism represent fundamental and interdependent biological systems. While tissue factor pathway inhibitor (TFPI) is the major physiological inhibitor of TF, its unique structure and endothelial expression allow multi-modal interactions with constituent molecules in each of these systems. We review emerging data describing roles for TFPI beyond simply opposing the action of TF, particularly with regard to the highly basic c-terminus of TFPI, and highlight potentially exciting new areas for future research.
Holroyd
Eric W
EW
Division of Cardiovascular Diseases, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.
Simari
Robert D
RD
D000465:Algorithms; D050197:Atherosclerosis; D001777:Blood Coagulation; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation; D008055:Lipids / Q000737:chemistry; D008074:Lipoproteins / Q000737:chemistry; D008954:Models, Biological; D009389:Neovascularization, Pathologic; D017434:Protein Structure, Tertiary; D013925:Thromboplastin / Q000378:metabolism*
D008055:Lipids; D008074:Lipoproteins; C051928:lipoprotein-associated coagulation inhibitor; D013925:Thromboplastin