Now you see it, now you don't--closing in on allostasis and developmental basis of psychiatric disorders.
The mode through which early insults in brain development result in the onset of psychiatric disorders years after impact become a little less mysterious with the report by Niwa et al. that a transient reduction of the schizophrenia risk gene DISC1 can alter prefrontal cortex neurochemistry, architecture, and function.
Thompson
Barbara L
BL
Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
Levitt
Pat
P
D052636:Allostasis; D000818:Animals; D004298:Dopamine / Q000378:metabolism; D018014:Gene Transfer Techniques; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009474:Neurons / Q000378:metabolism; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism
C498794:Disc1 protein, mouse; D009419:Nerve Tissue Proteins; D004298:Dopamine