title: [Perioperative management of a patient with deep vein thrombosis caused by estrogen producing granulosa cell tumor of the ovary].
abstract: We experienced perioperative management of a woman with large thrombi in femoral veins caused by estrogen producing ovarian tumor. At presentation, serum estradiol level was extremely high. Time constraint due to rapid expansion of the tumor did not allow us a trial of preoperative anti-coagulation. We placed a temporary IVC filter and proceeded with operation. As catastrophic pulmonary embolism could occur even with the presence of a filter, we prepared for institution of cardiopulmonary bypsss and pulmonary embolectomy via full sternotomy. We monitored arterial pressure based-cardiac output for immediate detection of pulmonary embolism. Postoperatively, serum estradiol level declined to normal range by postoperative day 7, and thrombi dissolved with anticoagulation therapy with warfarin and heparin without recurrence. In this case, surgery without preoperative anticoagulation was considered to pose extreme risk of perioperative pulmonary embolism. However, we considered that the thrombi would disolve by the removal of the tumor because estradiol production was the primary cause of thrombi. With above mentioned perioperative approach, the patient was managed uneventfully.
authors.affiliation: Department of Anesthesia, Kosei Hospital, Tokyo 164-8617.
authors.forename: Naoko
authors.initials: N
authors.lastname: Nakaigawa
authors.forename: Ryu
authors.initials: R
authors.lastname: Komatsu
authors.forename: Keiko
authors.initials: K
authors.lastname: Hamada
authors.forename: Kotoe
authors.initials: K
authors.lastname: Kamata
authors.forename: Makoto
authors.initials: M
authors.lastname: Ozaki
mesh_terms: D000368:Aged; D000758:Anesthesia; D004967:Estrogens / Q000096:biosynthesis*; D005260:Female; D006106:Granulosa Cell Tumor / Q000150:complications / Q000378:metabolism / Q000601:surgery*; D006801:Humans; D010051:Ovarian Neoplasms / Q000150:complications / Q000378:metabolism / Q000601:surgery*; D019990:Perioperative Care; D011183:Postoperative Complications / Q000517:prevention & control; D011655:Pulmonary Embolism / Q000517:prevention & control; D016306:Vena Cava Filters; D020246:Venous Thrombosis / Q000209:etiology*
chemical_list: D004967:Estrogens