Transition metal complexes of 3-aryl-2-substituted 1,2-dihydroquinazolin-4(3H)-one derivatives: new class of analgesic and anti-inflammatory agents.
Five-coordinate, neutral transition metal complexes of newly designed pyridine-2-ethyl-(3-carboxylideneamino)-3-(2-phenyl)-1,2-dihydroquinazolin-4(3H)-one (L) were synthesized and characterized. The structure of ligand is confirmed by single crystal X-ray diffraction studies. The compounds were evaluated for the anti-inflammatory activity by carrageenan-induced rat paw edema model while their analgesic activity was determined by acetic acid-induced writhing test in mice wherein the transition metal complexes were found to be more active than the free ligand.
Hoonur
Rekha S
RS
Department of Chemistry, Karnatak University, Pavate Nagar, Dharwad, Karnataka 580003, India.
Patil
Basavaraj R
BR
Badiger
Dayananda S
DS
Vadavi
Ramesh S
RS
Gudasi
Kalagouda B
KB
Dandawate
Prasad R
PR
Ghaisas
Mahesh M
MM
Padhye
Subhash B
SB
Nethaji
Munirathinam
M
D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018360:Crystallography, X-Ray; D015195:Drug Design; D004487:Edema / Q000188:drug therapy; D051379:Mice; D009942:Organometallic Compounds / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D011799:Quinazolines / Q000737:chemistry*; D051381:Rats; D013057:Spectrum Analysis; D028561:Transition Elements / Q000737:chemistry*
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D009942:Organometallic Compounds; D011799:Quinazolines; D028561:Transition Elements