A New UK 2006 National Kidney Allocation Scheme for deceased heart-beating donor kidneys.
In 2004, it was agreed that a new allocation scheme for kidneys from deceased heart-beating donors was required in the United Kingdom to address observed inequities in access to transplant. The 2006 National Kidney Allocation Scheme (2006 NKAS) was developed to meet agreed objectives and preparatory work included a review of the criteria for human leukocyte antigen (HLA) matching and simulation evidence about the effectiveness of alternative schemes. ALGORITHM FOR 2006 NKAS: The 2006 NKAS gives absolute priority to all 000 HLA-A, -B, -DR-mismatched patients and well-matched pediatric patients (<18 years), and then a points score defines priorities for allocation with waiting time being most influential. Points for age and HLA mismatch are linked in a novel approach to ensure well-matched transplants for younger patients while recognizing that HLA matching is less important for older patients as retransplantation is less likely to be required. To improve equity for difficult to match patients, rare HLA specificities were defaulted to more common, related specificities. IMPACT OF 2006 NKAS: After 3 years, the scheme is already making good progress in achieving its objectives, with overall results similar to those observed in the simulations. There has been a significant benefit for patients waiting more than 5 years for transplant. A number of other advantages of the scheme are also apparent with equity of access improving in many respects, including the achievement of equity of access to transplant for HLA-DR homozygous patients, but geographical inequity of access will take a number of years to address fully.
Johnson
Rachel J
RJ
Organ Donation and Transplantation, NHS Blood and Transplant, Fox Den Road, Stoke Gifford, Bristol BS34 8RR, United Kingdom. rachel.johnson@nhsbt.nhs.uk
Fuggle
Susan V
SV
Mumford
Lisa
L
Bradley
J Andrew
JA
Forsythe
John L R
JL
Rudge
Chris J
CJ
D000328:Adult; D002102:Cadaver; D002648:Child; D003695:Delivery of Health Care / Q000592:standards; D006085:Graft Survival; D006680:HLA Antigens / Q000276:immunology; D006339:Heart Rate; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology / Q000401:mortality / Q000706:statistics & numerical data*; D018579:Patient Selection; D040841:Resource Allocation / Q000379:methods* / Q000592:standards; D015996:Survival Rate; D014019:Tissue Donors / Q000706:statistics & numerical data*; D016896:Treatment Outcome; D006113:United Kingdom; D014850:Waiting Lists
D006680:HLA Antigens