title: Rate of occurrence, gross appearance, and age relation of hyperostosis frontalis interna in females: a prospective autopsy study.
abstract: The aim of our study was to determine rate of occurrence and appearance of hyperostosis frontalis interna (HFI) in females and correlation of this phenomenon with ageing. The sample included 248 deceased females: 45 of them with different types of HFI, and 203 without HFI, average age 68.3 +/- 15.4 years (range, 19-93), and 58.2 +/- 20.2 years (range, 10-101), respectively. According to our results, the rate of HFI was 18.14%. The older the woman was, the higher the possibility of HFI occurring (Pearson correlation 0.211, N=248, P=0.001), but the type of HFI did not correlate with age (Pearson correlation 0.229, N=45, P=0.131). Frontal and temporal bone were significantly thicker in women with than in women without HFI (t= -10.490, DF=246, P=0.000, and t= -5.658, DF=246, P=0.000, respectively). These bones became thicker with ageing (Pearson correlation 0.178, N=248, P=0.005, and 0.303, N=248, P=0.000, respectively). The best predictors of HFI occurrence were respectively, frontal bone thickness, temporal bone thickness, and age(Wald. coeff.=35.487, P=0.000; Wald. coeff.=3.288, P=0.070, and Wald.coeff. =2.727, P =0.099). Diagnosis of HFI depends not only on frontal bone thickness, but also on waviness of internal plate of the frontal bone, as well as-the involvement of the inner bone surface.
authors.affiliation: Institute of Forensic Medicine, 31a Deligradskastr., Belgrade, Serbia. bobanvladislav@yahoo.com
authors.forename: Slobodan
authors.initials: S
authors.lastname: Nikolić
authors.forename: Danijela
authors.initials: D
authors.lastname: Djonić
authors.forename: Vladimir
authors.initials: V
authors.lastname: Zivković
authors.forename: Dragan
authors.initials: D
authors.lastname: Babić
authors.forename: Fehim
authors.initials: F
authors.lastname: Juković
authors.forename: Marija
authors.initials: M
authors.lastname: Djurić
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D005260:Female; D049429:Forensic Pathology; D005624:Frontal Bone / Q000473:pathology*; D006801:Humans; D006957:Hyperostosis Frontalis Interna / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013701:Temporal Bone / Q000473:pathology*; D055815:Young Adult