title: Now you see it, now you don't--closing in on allostasis and developmental basis of psychiatric disorders.
abstract: The mode through which early insults in brain development result in the onset of psychiatric disorders years after impact become a little less mysterious with the report by Niwa et al. that a transient reduction of the schizophrenia risk gene DISC1 can alter prefrontal cortex neurochemistry, architecture, and function.
authors.affiliation: Department of Cell and Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90089, USA.
authors.forename: Barbara L
authors.initials: BL
authors.lastname: Thompson
authors.forename: Pat
authors.initials: P
authors.lastname: Levitt
mesh_terms: D052636:Allostasis; D000818:Animals; D004298:Dopamine / Q000378:metabolism; D018014:Gene Transfer Techniques; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009474:Neurons / Q000378:metabolism; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism
chemical_list: C498794:Disc1 protein, mouse; D009419:Nerve Tissue Proteins; D004298:Dopamine