Highly diastereoselective Friedel-Crafts reaction of indoles with an N-tert-butanesulfinylimino ester: an efficient and practical approach to enantiomerically enriched alpha-(3-indolyl)glycines.
An efficient, mild and general method for the preparation of highly enantiomerically enriched alpha-(3-indolyl)glycines by the transition-metal-based Lewis acid-catalyzed diastereoselective Friedel-Crafts reaction of indoles with an N-tert-butanesulfinylimino ester has been developed.
Ji
Du-Ming
DM
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, P. R. China.
Xu
Ming-Hua
MH
D000143:Acids / Q000737:chemistry; D002384:Catalysis; D018360:Crystallography, X-Ray; D004952:Esters; D005998:Glycine / Q000031:analogs & derivatives* / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D008968:Molecular Conformation; D013237:Stereoisomerism; D028561:Transition Elements / Q000737:chemistry
D000143:Acids; D004952:Esters; D007211:Indoles; D028561:Transition Elements; D005998:Glycine