One new guaiane-type sesquiterpene glycoside from the fruits of Daucus carota L.
A new guaiane-type sesquiterpene glycoside, torilolone 8-O-beta-D-glucopyranoside (1), together with a known analogue compound, torilolone 11-O-beta-D-glucopyranoside (2), was isolated from the fruits of Daucus carota L. Their chemical structures were elucidated on the basis of MS, NMR spectroscopic analyses coupled with chemical degradation. The cytotoxic activities of two isolated compounds were evaluated against two human gastric cancer cell lines BGC-823 and AGS using MTT assay.
Fu
Hong-Wei
HW
College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, P. R. China.
Zhang
Lin
L
Yi
Tao
T
Feng
Yu-Lin
YL
Tian
Jing-Kui
JK
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D002236:Carbohydrate Conformation; D045744:Cell Line, Tumor; D004396:Coloring Agents; D018552:Daucus carota / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry*; D005960:Glucosides / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry* / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000188:drug therapy; D013778:Tetrazolium Salts; D013844:Thiazoles
D000972:Antineoplastic Agents, Phytogenic; D004396:Coloring Agents; D005960:Glucosides; D006027:Glycosides; D045789:Sesquiterpenes, Guaiane; D013778:Tetrazolium Salts; D013844:Thiazoles; C547965:torilolone 8-O-beta-D-glucopyranoside; C022616:thiazolyl blue