title: Genetic diversity of growth hormone receptor gene in cattle.
abstract: Growth hormone receptor (GHR) belongs to a member of the cytokine receptor superfamily. Polymorphism of presence or absence of an approximately 1.2 kbp LINE-1 element is observed in bovine GHR gene. The present study was carried out for estimating the genetic diversity and the origin of the LINE-1 element in 10 European, Southeastern Asian and East Asian cattle breeds or populations. Genotyping of the LINE-1 revealed predominant LINE-1 presence in European breeds (0.917-0.991), absence in the Bos taurus indicus populations (0.000-0.017), and intermediate presence in Northeast Asian cattle (0.417-0.522). From genetic features of LINE families, LINE-1 of GHR could be attributed to the same origin in both European and Asian cattle, and Asian LINE-1 may not be derived from recent introgression. This result suggested that LINE-1 in bovine GHR gene could have arisen in an ancestral population of Bos taurus taurus.
authors.affiliation: Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Nada, Kobe, Japan.
authors.forename: Bang Zhong
authors.initials: BZ
authors.lastname: Lin
authors.forename: Shinji
authors.initials: S
authors.lastname: Sasazaki
authors.forename: June Heon
authors.initials: JH
authors.lastname: Lee
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Mannen
mesh_terms: D000818:Animals; D001947:Breeding; D002417:Cattle / Q000235:genetics*; D014644:Genetic Variation; D005828:Genetics, Population; D020084:Long Interspersed Nucleotide Elements / Q000235:genetics*; D011986:Receptors, Somatotropin / Q000235:genetics*
chemical_list: D011986:Receptors, Somatotropin