title: Case of localized scleroderma associated with osteomyelitis.
abstract: We report a 4-year-old girl presenting with progressive linear scleroderma affecting the right leg. Biopsy specimen disclosed typical histopathological findings of localized scleroderma. Right leg magnetic resonance imaging (MRI) showed high signal areas on T(2)-weighted images on the subcutaneous fatty tissue, muscles and bone marrow, suggesting that skin inflammation extended to the bone marrow. Oral corticosteroid therapy was instituted with improvement of both skin sclerosis and MRI findings. Our observations suggest that MRI examination should be considered in patients with localized scleroderma to evaluate the extension of the inflammation.
authors.affiliation: Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Muroi
authors.forename: Fumihide
authors.initials: F
authors.lastname: Ogawa
authors.forename: Toshifumi
authors.initials: T
authors.lastname: Yamaoka
authors.forename: Fumiko
authors.initials: F
authors.lastname: Sueyoshi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Sato
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000974:Antibodies, Antinuclear / Q000097:blood; D001853:Bone Marrow / Q000473:pathology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007866:Leg; D008279:Magnetic Resonance Imaging; D010019:Osteomyelitis / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D012594:Scleroderma, Localized / Q000150:complications* / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000305:Adrenal Cortex Hormones; D000974:Antibodies, Antinuclear