Synthesis and redox-enzyme modulation by amino-1,4-dihydro-benzo[d][1,2]dithiine derivatives.
A convenient method to prepare a series of benzodithiine derivatives was developed, via the synthesis of cyclic disulfide building blocks containing an amino-group linker. Some of the novel cyclic disulfide compounds are shown to modulate the activity of the redox-enzyme glutathione reductase.
Espinosa
Sandraliz
S
School of Pharmacy, Medical Sciences Campus, University of Puerto Rico, PO Box 365067, San Juan, PR00936, Puerto Rico.
Solivan
Melissa
M
Vlaar
Cornelis P
CP