Thio-mediated synthesis of derivatized N-linked glycopeptides using isonitrile chemistry.
The reaction of oligosaccharide isonitriles with peptide thioacids in the presence of bulky thiophenol as activator to provide N-linked glycopeptides at room temperature is described.
Wu
Xiangyang
X
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA.
Yuan
Yu
Y
Li
Xuechen
X
Danishefsky
Samuel J
SJ