title: Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients.
abstract: OBJECTIVE
  To investigate the association of nephrolithiasis and solute carrier family 2, facilitated glucose transporter, member 9 (SLC2A9), also known as glucose transporter type 9, Glut9.
  
  
  METHODS
  A total of 145 participants were recruited in the period April-October 2008 from the Department of Mineral Research of the Medical School Osijek, Osijek, Croatia; 58 (40%) had confirmed nephrolithiasis and 87 (60%) were asymptomatic. Four single nucleotide polymorphisms (SNP) from the SLC2A9 gene were genotyped in both groups (rs733175, rs6449213, rs1014290, and rs737267).
  
  
  RESULTS
  There was a weak but significant association of all 4 SNPs and nephrolithiasis (P=0.029 for rs733175; P=0.006 for rs6449213; P=0.020 for rs1014290, and P=0.011 for rs737267). Logistic regression in an age- and sex-adjusted model suggested that genotype C/T for rs6449213 had odds ratio for nephrolithiasis of 2.89 (95% confidence interval 1.13-7.40). This SNP explained a total of 4.4% of nephrolithiasis variance.
  
  
  CONCLUSIONS
  Development of nephrolithiasis may be associated with SLC2A9 gene. Further studies are needed to clarify the role of SLC2A9 gene as a link between uric acid and nephrolithiasis.
authors.affiliation: Department of Medical Statistics, Epidemiology, and Medical Informatics, Andrija Stampar School of Public Health, Medical School, University of Zagreb, Rockefellerova 4, 10000 Zagreb, Croatia. opolasek@snz.hr
authors.forename: Ozren
authors.initials: O
authors.lastname: Polasek
authors.forename: Grgo
authors.initials: G
authors.lastname: Gunjaca
authors.forename: Ivana
authors.initials: I
authors.lastname: Kolcić
authors.forename: Lina
authors.initials: L
authors.lastname: Zgaga
authors.forename: Snjezana
authors.initials: S
authors.lastname: Dzijan
authors.forename: Robert
authors.initials: R
authors.lastname: Smolić
authors.forename: Martina
authors.initials: M
authors.lastname: Smolić
authors.forename: Jasminka
authors.initials: J
authors.lastname: Milas-Ahić
authors.forename: Vatroslav
authors.initials: V
authors.lastname: Serić
authors.forename: Josip
authors.initials: J
authors.lastname: Galić
authors.forename: Sandra
authors.initials: S
authors.lastname: Tucak-Zorić
authors.forename: Antun
authors.initials: A
authors.lastname: Tucak
authors.forename: Igor
authors.initials: I
authors.lastname: Rudan
authors.forename: Gordan
authors.initials: G
authors.lastname: Lauc
mesh_terms: D000328:Adult; D000368:Aged; D017523:Croatia; D005260:Female; D005820:Genetic Testing; D051246:Glucose Transport Proteins, Facilitative / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D053040:Nephrolithiasis / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D051246:Glucose Transport Proteins, Facilitative; C411811:SLC2A9 protein, human