title: Efficient Synthesis of the 2-amino-6-chloro-4-cyclopropyl-7-fluoro-5-methoxy-pyrido[1,2-c]pyrimidine-1,3-dione core ring system.
abstract: An optimized total synthesis of the 2-amino-6-chloro-4-cyclopropyl-7-fluoro-5-methoxy-pyrido[1,2-c]pyrimidine-1,3-dione core structure of a new fluoroquinolone-like class of antibacterial agents is described. This synthesis is highlighted by a nearly quantitative ring-closing reaction to form the pyrido[1,2-c]pyrimidine core. This bicyclic ring system serves as a scaffold for a family of biologically active compounds.
authors.affiliation: Division of Medicinal & Natural Products Chemistry, University of Iowa, Iowa City, Iowa 52242, USA.
authors.forename: Jonathan D
authors.initials: JD
authors.lastname: Rosen
authors.forename: Nadezhda
authors.initials: N
authors.lastname: German
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Kerns