title: Dowling-Degos disease.
abstract: Dowling-Degos disease (DDD) is a rare autosomal dominant inherited pigmentary disorder of the flexures with a reticulate aspect and with presence of prominent comedone-like lesions and pitted scars. The diagnosis includes acanthosis nigricans as well as other reticulate pigmentary disorders classified into: dyschromatrosis symmetrica hereditaria (DSH), dyschromatosis universalis hereditaria (DUH) and reticulate acropigmentation of Kitamura (RAPK). We present a 35-year-old woman, which presented with flexural hyperpigmentation considerate as acanthosis nigricans. At a close clinical and histopathological examination, we obtained sure data for Dowling-Degos disease, with a possible familial history of this disease in her son. We review the literature data concerning this disease.
authors.affiliation: Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, and Pediatric Clinic, Filantropia Hospital, Craiova, Romania. efg@usa.net
authors.forename: E F
authors.initials: EF
authors.lastname: Georgescu
authors.forename: Ligia
authors.initials: L
authors.lastname: Stănescu
authors.forename: Carmen Florina
authors.initials: CF
authors.lastname: Popescu
authors.forename: Maria
authors.initials: M
authors.lastname: Comănescu
authors.forename: Iuliana
authors.initials: I
authors.lastname: Georgescu
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D030342:Genetic Diseases, Inborn / Q000175:diagnosis; D006801:Humans; D010859:Pigmentation Disorders / Q000175:diagnosis*