title: Anti-inflammatory and antimicrobial activities of Hippocratea indica root bark and Poga oleosa fruits.
abstract: The methanolic extracts of Hippocratea indica root bark and Poga oleosa fruits were investigated for anti-inflammatory and antimicrobial activities. Both extracts inhibited carrageenan-induced paw oedema significantly in rats in a dose-dependent manner in 4 h. H. indica inhibited oedema significantly at the minimal dose (125 mg/ml, p< 0.05) from 2 h onward, and gave 100% inhibition in 4 h. at 250 mg/kg. It was shown to be a more potent anti-inflammatory agent than P. oleosa. Also, H. indica extract exhibited greater antimicrobial activity against tested bacteria, with Staphylococcus aureus being the most susceptible bacterium (MIC, 16 mg/ml). Both plants were inactive against Candida albicans. These results confirm the anti-inflammatory and antibacterial activities of the two plants.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu campus, Ogun State, Nigeria.
authors.forename: O O
authors.initials: OO
authors.lastname: Ogbole
authors.forename: M N
authors.initials: MN
authors.lastname: Ekor
authors.forename: B B
authors.initials: BB
authors.lastname: Oluremi
authors.forename: E O
authors.initials: EO
authors.lastname: Ajaiyeoba
authors.forename: A A
authors.initials: AA
authors.lastname: Gbolade
authors.forename: M A
authors.initials: MA
authors.lastname: Ayoola
authors.forename: A A
authors.initials: AA
authors.lastname: Adeyemi