In vivo screening of antimalarial activity of Acacia mellifera (Benth) (Leguminosae) on Plasmodium berghei in mice.
The activities of total extracts and lupane triterpenes, isolated from the stem bark of Acacia mellifera, were evaluated against Plasmodium berghei strain ANKA in a female Swiss mouse model. Five isolated compounds and the crude extracts were evaluated for antimalarial activity and Quinine hydrochloride was used as a positive control. Only betulin and the methanolic extract produced considerable antimalarial activity in mice infected with P. berghei parasites. This study demonstrated the presence of bioactive agents in Acacia mellifera.
Mutai
Charles
C
Kenya Medical Research Institute, P.O Box 548540-00200, Nairobi, Kenya. cmutai@kemri.org
Rukunga
Geoffrey
G
Vagias
Constatinos
C
Roussis
Vassilios
V