Reduced beta-catenin expression is associated with good prognosis in Astrocytoma.
The aim of this study was to evaluate the expression of beta-catenin in astrocytoma, and the clinical relevance and prognostic significance of the expression of beta-catenin was also analyzed. Immunohistochemistry was performed on 63 resected astrocytoma tumor specimens to detect the expression of beta-catenin. The correlation between the results of immuoexpression and the clinicopathologic parameters and patient survival was processed statistically. In 63 samples of astrocytoma, 36 cases were immunoreactive for beta-catenin at cytoplasm, ten cases of astrocytoma were immunoreactive at cytomembrane, and four cases of astrocytoma were stained for beta-catenin at nucleus. Spearman analysis showed that the distribution of beta-catenin was not correlated with the grades of astrocytoma. However, the expression profiles were correlated with the patient's 2-year survival, but not correlated with the grades, tumor size, sex, age, or tumor location. Patients with low beta-catenin expression levels tended to be associated with a better prognosis than those who with high levels (p = 0.042). Our results suggest that beta-catenin is useful for the prognosis evaluation of astrocytoma.
Zhang
Li-Ying
LY
State Key Laboratory of Cancer Biology and Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
Jiang
Li-Na
LN
Li
Fan-Fan
FF
Li
Hang
H
Liu
Fang
F
Gu
Yu
Y
Song
Yue
Y
Zhang
Feng
F
Ye
Jing
J
Li
Qing
Q
D000293:Adolescent; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis*; D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology; D002648:Child; D005260:Female; D015870:Gene Expression; D020869:Gene Expression Profiling; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D055815:Young Adult; D051176:beta Catenin / Q000096:biosynthesis* / Q000235:genetics
D014408:Biomarkers, Tumor; D051176:beta Catenin