Rapid determination of lithium in serum samples by capillary electrophoresis.
Lithium salts are still one of the most popular therapeutic approaches to the treatment of bipolar disorders, notwithstanding the introduction of more modern, less toxic drugs. Because of a narrow therapeutic range, lithium serum concentrations must be strictly monitored during the treatment to avoid life-threatening neurotoxicity. For this purpose, methods based on flame photometry or ion-selective electrodes are usually applied. The aim of the present work was to develop and validate a simple method for the determination of lithium in serum based on capillary zone electrophoresis with indirect detection. A validation of the method was carried out, including a comparison with an automated routine method based on ion-selective electrodes.
Pascali
Jennifer P
JP
Department of Medicine and Public Health, Unit of Forensic Medicine, University of Verona, P.le L.A. Scuro 10, 37134 Verona, Italy. jennifer.pascali@univr.it
Sorio
Daniela
D
Bortolotti
Federica
F
Tagliaro
Franco
F
D001774:Blood Chemical Analysis / Q000379:methods*; D016903:Drug Monitoring / Q000379:methods*; D019075:Electrophoresis, Capillary / Q000379:methods*; D006801:Humans; D018020:Lithium Compounds / Q000097:blood*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D018020:Lithium Compounds