Effects of oxidized cooking oil and α-lipoic acid on liver antioxidants: enzyme activities and lipid peroxidation in rats fed a high fat diet.
The effects of administration of oxidized rapeseed oil and α-lipoic acid on activities of hepatic antioxidant enzymes and lipid peroxidation were studied in laboratory rats. There was an increase of the activities of superoxide dismutase, glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase in rats fed a high fat diet to which 10% oxidized oil was added. Administration of α-lipoic acid resulted in a decrease of the activities of these enzymes. Addition of oxidized oil also resulted in increased production of oxygen radicals, evidenced by elevated malondialdehyde production. Such effect was counteracted by administration of α-lipoic acid.
Zalejska-Fiolka
Jolanta
J
Department of Biochemistry, Silesian University of Medicine, Zabrze, Poland. jolafiolka@wp.pl
Wielkoszyński
Tomasz
T
Kasperczyk
Sławomir
S
Kasperczyk
Aleksandra
A
Birkner
Ewa
E
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D005227:Fatty Acids / Q000494:pharmacology*; D005980:Glutathione Reductase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D008063:Thioctic Acid / Q000494:pharmacology*
D000975:Antioxidants; D004041:Dietary Fats; D005227:Fatty Acids; D008315:Malondialdehyde; D008063:Thioctic Acid; D013482:Superoxide Dismutase; D005980:Glutathione Reductase