Methods of recruiting adolescents with psychiatric and substance use disorders for a clinical trial.
BACKGROUND
The present article reports on recruiting strategies in a 16-week, multi-site trial of osmotic-release methylphenidate combined with cognitive-behavioral therapy in adolescents with co-occurring attention deficit hyperactivity disorder and substance use disorder.


METHODS
A multifaceted recruiting strategy was employed that targeted multiple referral sources, used incentives, involved numerous staff members, emphasized the therapeutic alliance during prescreening, and utilized data to modify strategies based on results. Overall, 303 adolescents were randomized from 1,333 total referrals across 11 participating sites.


RESULTS
Overall, existing treatment program sources, including treatment program staff, social services, the juvenile justice system, and mental health clinics provided a majority of referrals for pre-screening and randomization.


CONCLUSIONS
These results support the feasibility of recruiting dually-diagnosed adolescents utilizing a multifaceted approach involving the entire study team.
Jaffee
William B
WB
Mclean Hospital, Harvard Medical School, Massachusetts, USA.
Bailey
Genie L
GL
Lohman
Michelle
M
Riggs
Paula
P
McDonald
Leah
L
Weiss
Roger D
RD
D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis* / Q000628:therapy; D002986:Clinical Trials as Topic; D015928:Cognitive Behavioral Therapy; D003155:Community Mental Health Centers; D017831:Diagnosis, Dual (Psychiatry); D006801:Humans; D008774:Methylphenidate / Q000627:therapeutic use; D015337:Multicenter Studies as Topic; D018579:Patient Selection; D016032:Randomized Controlled Trials as Topic; D012017:Referral and Consultation; D012947:Social Work; D016320:Substance Abuse Treatment Centers; D019966:Substance-Related Disorders / Q000175:diagnosis*
D008774:Methylphenidate