title: Ceramides and cerebrosides from the marine bryozoan Bugula neritina inhabiting South China Sea.
abstract: From the marine bryozoan Bugula neritina inhabiting South China Sea, a new ceramide named (2S,3R,4E)-2-(14'-methyl-pentadecanoylamino)-4-octadecene-l,3-diol (1) and a new cerebroside named 1-O-(beta-D-glucopyranosyl)-(2S,3R,4E)-2-(heptadecanoylamino)-4-octadecene-l,3-diol (6), together with one known ceramide (2) and three known cerebrosides (3, 4, and 5), were isolated. Their structures were deduced by extensive spectral analysis and chemical evidences. Compound 1 is branched with a methyl [-CH(CH(3))(2)] in the fatty acid moiety, which is a rare structural feature among ceramides. Compound 6 is a new cerebroside with 17 carbons in the fatty acid moiety, while 5 is a new natural product which was isolated from a natural origin for the first time.
authors.affiliation: Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
authors.forename: Xiang-Rong
authors.initials: XR
authors.lastname: Tian
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Tang
authors.forename: Yu-Shan
authors.initials: YS
authors.lastname: Li
authors.forename: Hou-Wen
authors.initials: HW
authors.lastname: Lin
authors.forename: Ning
authors.initials: N
authors.lastname: Ma
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Min-Na
authors.initials: MN
authors.lastname: Yao
mesh_terms: D000818:Animals; D002013:Bryozoa / Q000737:chemistry*; D002518:Ceramides / Q000737:chemistry / Q000302:isolation & purification*; D002554:Cerebrosides / Q000737:chemistry / Q000302:isolation & purification*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D009792:Oceans and Seas; D013237:Stereoisomerism
chemical_list: C548609:(2S,3R,4E)-2-(14'-methyl-pentadecanoylamino)-4-octadecene-l,3-diol; C548608:1-O-(beta-D-glucopyranosyl)-(2S,3R,4E)-2-(heptadecanoylamino)-4-octadecene-l,3-diol; D002518:Ceramides; D002554:Cerebrosides