title: Current neoadjuvant strategies in rectal cancer.
abstract: Treatment modalities in rectal cancer have undergone a slow, evolutionary transition over the past 30 years. More recently, contemporary descriptions of advanced preoperative chemotherapy and radiation schema have led to a rapid revolution in the management of this disease. In this review we focus on current evidence-based neoadjuvant strategies used in the treatment of locally advanced rectal cancer and metastatic rectal disease. Finally, we provide a foundation for discussion of still unresolved issues.
authors.affiliation: Colon and Rectal Surgery, Inc., Omaha, Nebraska, USA.
authors.forename: Lucas A
authors.initials: LA
authors.lastname: Julien
authors.forename: Alan G
authors.initials: AG
authors.lastname: Thorson
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D006801:Humans; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents