title: Brief spatial experiences increase granule cell survival in the dentate gyrus of adult rats.
abstract: Rats of two experimental groups were placed in an open-field apparatus for 3-5 spatial exploration, each placement lasting 5min (total duration of 15-25min), and had a significantly greater newborn-neuron survival rate of the granule cells than the control group by evaluating the density of 5-bromo-2'deoxyuridine positive cells in the dentate gyrus. This study suggests that brief spatial experiences are sufficient to enhance the survival rate of newborn neurons.
authors.affiliation: Department of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC.
authors.forename: Kuan-Lin
authors.initials: KL
authors.lastname: Feng
authors.forename: Su-Ping
authors.initials: SP
authors.lastname: Wang
authors.forename: Yi-Sian
authors.initials: YS
authors.lastname: Wu
authors.forename: Pei-Yi
authors.initials: PY
authors.lastname: Lin
authors.forename: Mei-Yun
authors.initials: MY
authors.lastname: Tai
authors.forename: Yuan-Feen
authors.initials: YF
authors.lastname: Tsai
mesh_terms: D000375:Aging; D000704:Analysis of Variance; D000818:Animals; D001973:Bromodeoxyuridine; D002452:Cell Count; D002470:Cell Survival / Q000502:physiology; D018891:Dentate Gyrus / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology; D008297:Male; D055495:Neurogenesis; D009474:Neurons / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D020318:Rats, Long-Evans; D013028:Space Perception / Q000502:physiology*; D013997:Time Factors
chemical_list: D001973:Bromodeoxyuridine