Synthesis and in vitro Efficacy Studies of Silver Carbene Complexes on Biosafety Level 3 Bacteria.
A series of N-heterocyclic carbene silver complexes have been synthesized and tested against the select group of bio-safety level 3 bacteria Burkholderia pseudomallei, Burkholderia mallei, Bacillus anthracis, methicillin-resistant Staphylococcus aureus and Yersinia pestis. Minimal inhibitory concentrations, minimal bactericidal and killing assays demonstrated the exceptional efficacy of the complexes against these potentially weaponizable pathogens.
Panzner
Matthew J
MJ
Department of Chemistry, University of Akron, Akron, OH 44325-3601, USA.
Deeraksa
Arpaporn
A
Smith
Alyssa
A
Wright
Brian D
BD
Hindi
Khadijah M
KM
Kascatan-Nebioglu
Aysegul
A
Torres
Alfredo G
AG
Judy
Barbara M
BM
Hovis
Christine E
CE
Hilliard
Julia K
JK
Mallett
Rebekah J
RJ
Cope
Emily
E
Estes
D Mark
DM
Cannon
Carolyn L
CL
Leid
Jeff G
JG
Youngs
Wiley J
WJ