title: Health-beneficial effects of probiotics: Its mode of action.
abstract: It is now widely recognized that probiotics have health-beneficial effects on humans and animals. Probiotics should survive in the intestinal tract to exert beneficial effects on the host's health. To keep a sufficient level of probiotic bacteria in the gastrointestinal tract, a shorter interval between doses may be required. Although adherence to the intestinal epithelial cell and mucus is not a universal property of probiotics, high ability to adhere to the intestinal surface might strongly interfere with infection of pathogenic bacteria and regulate the immune system. The administration of probiotic Lactobacillus stimulated indigenous Lactobacilli and the production of short-chain fatty acids. This alteration of the intestinal environment should contribute to maintain the host's health. The immunomodulatory effects of probiotics are related to important parts of their beneficial effects. Probiotics may modulate the intestinal immune response through the stimulation of certain cytokine and IgA secretion in intestinal mucosa. The health-beneficial effects, in particular the immunomodulation effect, of probiotics depend on the strain used. Differences in indigenous intestinal microflora significantly alter the magnitude of the effects of a probiotic. Specific probiotic strains suitable for each animal species and their life stage as well as each individual should be found.
authors.affiliation: Department of Food Science and Technology, Nippon Veterinary and Life Science University, Musashino, Tokyo, Japan. ohashi@nvlu.ac.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ohashi
authors.forename: Kazunari
authors.initials: K
authors.lastname: Ushida
mesh_terms: D000818:Animals; D005769:Gastrointestinal Motility; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D056747:Immunomodulation; D007413:Intestinal Mucosa / Q000276:immunology; D019936:Probiotics / Q000494:pharmacology*; D013552:Swine