In vivo wound healing and antibacterial performances of electrospun nanofibre membranes.
In this work, nanofibre membranes have been produced from polyvinyl alcohol (PVA), polycaprolactone (PCL), polyacrylonitrile (PAN), poly (vinylidene fluoride-co-hexafluoropropene) (PVdF-HFP), and polymer blend of PAN and polyurethane (PEU) using an electrospinning technique, and wound healing performance of the as-spun nanofibre membranes was examined in vivo using female Sprague-Dawley rats. To understand the nutrition effect, a wool protein was coated on PVA and PCL nanofibres and incorporated into PVA nanofibres via coelectrospinning of a PVA solution containing the wool protein. Silver nanoparticles were also applied to PVA nanofibres to improve antibacterial activity. It was found that the wound healing performance is mainly influenced by the porosity, air permeability, and surface wettability of the nanofibre membranes. A nanofibre membrane with good hydrophilicity and high porosity considerably facilitates the healing of wound especially at the early healing stage. However, the fiber diameter and antibacterial activity have little effect on the wound healing efficiency. As pores in nanofibre membranes are typically smaller than that of conventional cotton gauze, the nanofibre membrane should be able to decontaminate and prevent exogenous infections via sieve effect. This work provides basic understanding of material structure-property relationship for further design of efficient nanofibre-based wound dressing materials.
Liu
Xin
X
Centre for Material and Fibre Innovation, Deakin University, Geelong, VIC 3217, Australia.
Lin
Tong
T
Fang
Jian
J
Yao
Gang
G
Zhao
Hongqiong
H
Dodson
Michael
M
Wang
Xungai
X
D000180:Acrylic Resins / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001458:Bandages; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology; D055664:Electrochemical Techniques; D005260:Female; D008422:Materials Testing; D053768:Metal Nanoparticles; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D057139:Nanofibers / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry / Q000494:pharmacology; D011140:Polyurethanes / Q000737:chemistry / Q000494:pharmacology; D011142:Polyvinyl Alcohol / Q000737:chemistry / Q000494:pharmacology; D011145:Polyvinyls / Q000737:chemistry / Q000494:pharmacology; D016062:Porosity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012834:Silver / Q000737:chemistry / Q000494:pharmacology; D017155:Wettability; D014935:Wool / Q000737:chemistry; D014945:Wound Healing
D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D011091:Polyesters; D011140:Polyurethanes; D011145:Polyvinyls; C545920:poly(vinylidene fluoride-co-hexafluoro propylene); C016240:polycaprolactone; C010504:polyacrylonitrile; D012834:Silver; D011142:Polyvinyl Alcohol