OroSTIFF: Face-referenced measurement of perioral stiffness in health and disease.
A new device and automated measurement technology known as OroSTIFF is described to characterize non-participatory perioral stiffness in healthy adults for eventual application to patients with orofacial movement disorders associated with neuromotor disease, traumatic injury, or congenital clefts of the upper lip. Previous studies of perioral biomechanics required head stabilization for extended periods of time during measurement, which precluded sampling patients with involuntary body/head movements (dyskinesias), or pediatric subjects. The OroSTIFF device is face-referenced and avoids the complications associated with head-restraint. Supporting data of non-participatory perioral tissue stiffness using OroSTIFF are included from 10 male and 10 female healthy subjects. The OroSTIFF device incorporates a pneumatic glass air cylinder actuator instrumented for pressure, and an integrated subminiature displacement sensor to encode lip aperture. Perioral electromyograms were simultaneously sampled to confirm passive muscle state for the superior and inferior divisions of the orbicularis oris muscles. Perioral stiffness, derived as a quotient from resultant force (DeltaF) and interangle span (DeltaX), was modeled with multilevel regression techniques. Real-time calculation of the perioral stiffness function demonstrated a significant quadratic relation between imposed interangle stretch and resultant force. This stiffness growth function also differed significantly between males and females. This study demonstrates the OroSTIFF 'proof-of-concept' for cost-effective non-invasive stimulus generation and derivation of perioral stiffness in a group of healthy unrestrained adults, and a case study to illustrate the dose-dependent effects of Levodopa on perioral stiffness in an individual with advanced Parkinson's disease who exhibited marked dyskinesia and rigidity.
Chu
Shin-Ying
SY
Department of Speech-Language-Hearing Sciences and Disorders, Communication Neuroscience Laboratories, University of Kansas, 1000 Sunnyside Avenue, Rm 3001, Lawrence, Kansas 66045-7555, USA. shinying@ku.edu
Barlow
Steven M
SM
Kieweg
Douglas
D
Lee
Jaehoon
J
D000328:Adult; D055119:Elastic Modulus / Q000502:physiology; D004576:Electromyography / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005152:Facial Muscles / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009055:Mouth / Q000502:physiology*; D014159:Transducers; D055815:Young Adult