Design, synthesis, and in vitro antitumor evaluation of novel diaryl ureas derivatives.
Two series of novel diaryl ureas have been designed and synthesized, with their in vitro antitumor effect screened on human non-small cell lung cancer (NSCLC) cell line A549 and human breast cancer cell line MDA-MB-231. Some target compounds demonstrated significant inhibitory activities against both cell lines. Compared to contrast drug Sorafenib, 1b, 1d, 1f, 1i were found to demonstrate more potent antitumor activities. The structures of all the newly synthesized compounds were determined by 1H, 13C NMR, MS, IR and elementary analysis.
Sun
Min
M
Pharmaceutical Engineering Institute, School of Chemistry & Chemical Engineering, Southeast University, Nanjing 210096, PR China.
Wu
Xiaoqing
X
Chen
Junqing
J
Cai
Jin
J
Cao
Meng
M
Ji
Min
M
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015195:Drug Design; D006801:Humans; D020128:Inhibitory Concentration 50; D013057:Spectrum Analysis; D014508:Urea / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D014508:Urea