title: [Effects of dehydration and infusion of blood substitutes on the hemostasis system in an experiment with 21-hour bed rest].
abstract: Eight volunteered male test-subjects (20-40 y.o.) took part in an experiment with 21-hr bed rest aimed to investigate trends in the hemostasis parameters (activated partial thromboplastin time, prothrombin time, thrombin time, fibrinogen, plasminogen, D-dimers, soluble fibrin-monomer complexes (SFMC), as well as antithrombin III (ATIII) and protein C (antiplasmin) activities) after diuretics-induced dehydration followed by intravenous infusion of colloid and crystalloid solutions. It was shown that noncompensible dehydration during bed rest does not lead to noteworthy alterations in the procoagulating component of hemostasis. Intravenous infusion of blood substituting sterofundin (crystalloid) and venofundin (colloid) to the bedrested human subjects accelerated coagulation within the physiological norm. In all series of the experiment ATIII was suppressed and plasminogen content went down causing growth in SFMC. Fibrinogen concentration remained essentially unchanged pointing to the absence of acute reaction of organism to the experimental conditions.
authors.forename: D S
authors.initials: DS
authors.lastname: Kuzichkin
authors.forename: M V
authors.initials: MV
authors.lastname: Baranov
authors.forename: A S
authors.initials: AS
authors.lastname: Kovalev
authors.forename: L G
authors.initials: LG
authors.lastname: Repenkova
authors.forename: B V
authors.initials: BV
authors.lastname: Morukov
authors.forename: A A
authors.initials: AA
authors.lastname: Markin
mesh_terms: D000328:Adult; D001510:Bed Rest; D001802:Blood Substitutes / Q000008:administration & dosage*; D003102:Colloids / Q000008:administration & dosage; D000077324:Crystalloid Solutions; D003681:Dehydration / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy; D004232:Diuretics / Q000008:administration & dosage; D005500:Follow-Up Studies; D006487:Hemostasis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000008:administration & dosage; D008297:Male; D015532:Rehydration Solutions; D013997:Time Factors; D055815:Young Adult
chemical_list: D001802:Blood Substitutes; D003102:Colloids; D000077324:Crystalloid Solutions; D004232:Diuretics; D007552:Isotonic Solutions; D015532:Rehydration Solutions