Lin28: A microRNA regulator with a macro role.
Lin28, a highly conserved RNA-binding protein, has emerged as a modulator of the processing of the let-7 microRNA. This role for Lin28 has important implications for our mechanistic understanding of pluripotency, the timing of development, and oncogenesis.
Viswanathan
Srinivas R
SR
Children's Hospital Boston and Dana Farber Cancer Institute, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, and the Howard Hughes Medical Institute, MA 02115, USA.
Daley
George Q
GQ
D000818:Animals; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics*; D009369:Neoplasms / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D016601:RNA-Binding Proteins / Q000235:genetics*; D013234:Stem Cells / Q000378:metabolism
C000715187:Lin28A protein, human; D035683:MicroRNAs; D016601:RNA-Binding Proteins; C487931:mirnlet7 microRNA, human