title: Conservative treatment of a rare case of multifocal adenoid cystic carcinoma of the breast: case report and literature review.
abstract: BACKGROUND
  Adenoid cystic carcinoma of the breast is a rare neoplasm accounting for 0.1% of all malignant breast tumors and presenting most commonly as a painful breast mass. Compared with the more common histological forms of breast cancer, it has a more favorable prognosis and lymph node involvement or distant metastases seldom occur.
  
  
  METHODS
  A unique case of multifocal adenoid cystic carcinoma of the breast presenting as a painful and well-defined lump and treated with conservative surgery with adjuvant radiotherapy is reported.
  
  
  CONCLUSIONS
  There is no consensus on the optimal management of this disease. A breast-conserving approach may be recommended even if mastectomy has been traditionally the treatment of choice. Chemotherapy, radiation, and hormonal therapy have been infrequently used and so far have had no defined role in this kind of neoplasm. The authors found no other reports in the literature focusing on a conservative approach to multifocal adenoid cystic carcinoma.
authors.affiliation: Department of Surgery, Breast Unit, Catholic University, Rome, Italy. gianlucafranceschini@yahoo.it
authors.forename: Gianluca
authors.initials: G
authors.lastname: Franceschini
authors.forename: Daniela
authors.initials: D
authors.lastname: Terribile
authors.forename: Ilaria
authors.initials: I
authors.lastname: Scafetta
authors.forename: Stefano
authors.initials: S
authors.lastname: Magno
authors.forename: Cristina
authors.initials: C
authors.lastname: Fabbri
authors.forename: Federica
authors.initials: F
authors.lastname: Chiesa
authors.forename: Alba
authors.initials: A
authors.lastname: Di Leone
authors.forename: Francesca
authors.initials: F
authors.lastname: Moschella
authors.forename: Assunta
authors.initials: A
authors.lastname: Scaldaferri
authors.forename: Simona
authors.initials: S
authors.lastname: Fragomeni
authors.forename: Valerio
authors.initials: V
authors.lastname: Vellone
authors.forename: Antonio
authors.initials: A
authors.lastname: Mulè
authors.forename: Riccardo
authors.initials: R
authors.lastname: Masetti
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D003528:Carcinoma, Adenoid Cystic / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008327:Mammography; D014463:Ultrasonography