title: A Rhodium(I)-Xylyl-BINAP Catalyzed Asymmetric Ynamide-[2 + 2 + 2] Cycloaddition in the Synthesis of Optically Enriched N,O-Biaryls.
abstract: A rhodium(I)-xylyl-BINAP catalyzed asymmetric [2 + 2 + 2] cycloaddition of achiral conjugated aryl ynamides with various diynes is described here. This asymmetric cycloaddition provides a series of structurally interesting chiral N,O-biaryls with excellent enantioselectivity along with a modest diastereoselectivity with respect to both C-C and C-N axial chirality.
authors.affiliation: Division of Pharmaceutical Sciences and Department of Chemistry, University of Wisconsin, Madison, WI 53705 USA.
authors.forename: Jossian
authors.initials: J
authors.lastname: Oppenheimer
authors.forename: Whitney L
authors.initials: WL
authors.lastname: Johnson
authors.forename: Ruth
authors.initials: R
authors.lastname: Figueroa
authors.forename: Ryuji
authors.initials: R
authors.lastname: Hayashi
authors.forename: Richard P
authors.initials: RP
authors.lastname: Hsung