Cardioprotection by omega-3 fatty acids: involvement of PKCs?
It has been known since the 1970s that an increased consumption of n-3 long chain polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid has cardioprotective effects. Epidemiological studies have reported that this effect is due to the prevention of the arrhythmias responsible for sudden cardiac death. Mechanistically, different hypotheses have been put forward to give an explanation. Among them, there are a direct effect of the polyunsaturated fatty acids on ion channels and/or a modification of the regulation of ion channels by protein kinase C's.
Le Guennec
J-Y
JY
Inserm U637, Université Montpellier-2, Montpellier, France. Jean-Yves.Le-Guennec@Univ-Montp2.Fr
Jude
S
S
Besson
P
P
Martel
E
E
Champeroux
P
P
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000378:metabolism / Q000627:therapeutic use; D002316:Cardiotonic Agents / Q000378:metabolism / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D016757:Death, Sudden, Cardiac / Q000517:prevention & control; D015525:Fatty Acids, Omega-3 / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects; D011493:Protein Kinase C / Q000378:metabolism
D000889:Anti-Arrhythmia Agents; D002316:Cardiotonic Agents; D015525:Fatty Acids, Omega-3; D011493:Protein Kinase C