title: [Comparison of urinary output during general anesthesia, between patients administered with remifentanil and those without remifentanil administration].
abstract: BACKGROUND
  Transient renal failure during surgery is caused by increasing secretion of stress hormone such as ADH and renin. We suspected that urinary output varies according to administration of remifentanil with potent analgesic effects. Consequently, we studied intraoperative urinary output of two groups, patients administered with remifentanil and those without remifentanil administration.
  
  
  METHODS
  We compared urinary output during general anesthesia, of 327 patients administered with remifentanil (Group R) and 314 patients without remifentanil administration (Group NR) retrospectively. Patients were excluded if they were under the age of eighteen, receiving epidural anesthesia, or having medicine with diuretic effect.
  
  
  RESULTS
  There were no significant difference in background of the patients in each group, in particular, age, sex, body weight, and ASA grade. We found no significant difference in intraoperative factors; operation time, total blood loss, volume of infusion, anesthesia time, and given dose of fentanyl. Urinary output of Group R was estimated as 512 +/- 435 ml, and that of Group NR was 409 +/- 405 ml (P value was 0.02).
  
  
  CONCLUSIONS
  We found a significance difference in urinary output during anesthesia, between patients administered with remifentanil and those without remifentanil administration. We suspect that remifentanil decreases urinary output in the perioperative period.
authors.affiliation: Department of Anesthesiology, Toyohashi Municipal Hospital, Toyohashi 441-8570.
authors.forename: Miku
authors.initials: M
authors.lastname: Kawai
authors.forename: Jun
authors.initials: J
authors.lastname: Nakata
authors.forename: Michiko
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: Tetsuyuki
authors.initials: T
authors.lastname: Takahashi
authors.forename: Masato
authors.initials: M
authors.lastname: Hara
authors.forename: Shinya
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Megumi
authors.initials: M
authors.lastname: Maseki
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Teramoto
mesh_terms: D000328:Adult; D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology*; D000768:Anesthesia, General; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage / Q000494:pharmacology*; D000077208:Remifentanil; D012189:Retrospective Studies; D014554:Urination / Q000187:drug effects*
chemical_list: D000701:Analgesics, Opioid; D010880:Piperidines; D000077208:Remifentanil