title: Theta EEG source localization using LORETA in partial epilepsy patients with and without medication.
abstract: OBJECTIVE
  To investigate and localize the sources of spontaneous, scalp-recorded theta activity in patients with partial epilepsy (PE).
  
  
  METHODS
  Nine patients with beginning, untreated PE (Group 1), 31 patients with already treated PE (Group 2), and 14 healthy persons were investigated by means of spectral analysis and LORETA, low resolution electromagnetic tomography (1 Hz very narrow band analysis, age-adjusted, Z-scored values). The frequency of main interest was 4-8 Hz.
  
  
  RESULTS
  Group analysis: Group 1 displayed bilateral theta maxima in the temporal theta area (TTA), parietal theta area (PTA), and frontal theta area (FTA). In Group 2, theta activity increased all over the scalp as compared to the normative mean (Z=0) and also to Group 1. Maximum activity was found in the TTA, PTA, and FTA. However, in the PTA and FTA the centers of the abnormality shifted towards the medial cortex. Individual analysis: all the patients showed preferential activation (maximum Z-values) within one of the three theta areas.
  
  
  CONCLUSIONS
  EEG activity in the theta band is increased in anatomically meaningful patterns in PE patients, which differs from the anatomical distribution of theta in healthy persons.
  
  
  CONCLUSIONS
  The findings contribute to our understanding of the sources of theta rhythms and the pathophysiology of PE.
authors.affiliation: Kenézy Hospital Ltd., Department of Neurology, Debrecen, Hungary. bela.clemens@yahoo.com
authors.forename: B
authors.initials: B
authors.lastname: Clemens
authors.forename: M
authors.initials: M
authors.lastname: Bessenyei
authors.forename: I
authors.initials: I
authors.lastname: Fekete
authors.forename: S
authors.initials: S
authors.lastname: Puskás
authors.forename: I
authors.initials: I
authors.lastname: Kondákor
authors.forename: M
authors.initials: M
authors.lastname: Tóth
authors.forename: K
authors.initials: K
authors.lastname: Hollódy
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D001931:Brain Mapping / Q000379:methods*; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D012815:Signal Processing, Computer-Assisted; D013826:Theta Rhythm; D014054:Tomography / Q000379:methods
chemical_list: D000927:Anticonvulsants