title: Dipeptidyl peptidase IV and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) study.
abstract: OBJECTIVE
  Dipeptidyl peptidase IV (DPP-IV) is not only important in beta-cell function but also has proinflammatory actions. We aimed to investigate whether it could act as a link between low-grade chronic inflammation and diabetes.
  
  
  METHODS
  Using a case-cohort design, we followed 546 middle-aged individuals who developed diabetes and 538 who did not over approximately 9 years within the Atherosclerosis Risk in Communities study.
  
  
  RESULTS
  In weighted analyses, the correlation between DPP-IV levels and anthropometric, inflammatory, or metabolic variables was minimal (Spearman correlations <0.11). Those who developed diabetes had mean DPP-IV values similar to those who did not (P = 0.18). Individuals in the highest quartile of DPP-IV were not at greater risk of diabetes (hazard ratio 0.88 [95% CI 0.62-1.24]) in Cox proportional hazards models adjusting for age, sex, race, study center, and multiple additional diabetes risk factors.
  
  
  CONCLUSIONS
  Fasting DPP-IV levels do not appear to predict incident diabetes.
authors.affiliation: Graduate Studies Program in Epidemiology, School of Medicine, Federal University of Rio Grandedo Sul, Porto Alegre, Rio Grande do Sul, Brazil.
authors.forename: Vivian C
authors.initials: VC
authors.lastname: Luft
authors.forename: Maria Inês
authors.initials: MI
authors.lastname: Schmidt
authors.forename: James S
authors.initials: JS
authors.lastname: Pankow
authors.forename: Ron C
authors.initials: RC
authors.lastname: Hoogeveen
authors.forename: David
authors.initials: D
authors.lastname: Couper
authors.forename: Gerardo
authors.initials: G
authors.lastname: Heiss
authors.forename: Bruce B
authors.initials: BB
authors.lastname: Duncan
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D018819:Dipeptidyl Peptidase 4 / Q000097:blood* / Q000276:immunology; D005215:Fasting; D005260:Female; D006801:Humans; D015994:Incidence; D007249:Inflammation / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology
chemical_list: C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4