Adoptive T cell therapy of cancer.
Adoptive transfer of T cells specific for antigens expressed on tumor cells is an attractive strategy for producing targeted and long-lived anti-tumor activity. T cell therapies have shown activity in selected clinical applications but broader application is limited by inadequate persistence of transferred T cells and by tumor-evasion strategies. Current research focuses on defining the optimum type of cell for transfer, genetically modifying infused T cells to augment function and overcome tumor evasion strategies and modulating the host environment.
Brenner
Malcolm K
MK
Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston, TX, USA.
Heslop
Helen E
HE
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D018014:Gene Transfer Techniques; D006801:Humans; D016219:Immunotherapy, Adoptive; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D019076:Transgenes / Q000235:genetics / Q000276:immunology*; D019139:Tumor Escape
D000951:Antigens, Neoplasm; D011948:Receptors, Antigen, T-Cell