title: Radiation dose-volume effects in the heart.
abstract: The literature is reviewed to identify the main clinical and dose-volume predictors for acute and late radiation-induced heart disease. A clear quantitative dose and/or volume dependence for most cardiac toxicity has not yet been shown, primarily because of the scarcity of the data. Several clinical factors, such as age, comorbidities and doxorubicin use, appear to increase the risk of injury. The existing dose-volume data is presented, as well as suggestions for future investigations to better define radiation-induced cardiac injury.
authors.affiliation: Department of Medical Physics, Karolinska University Hospital and Karolinska Institute, Stockholm, Sweden. giovanna.gagliardi@karolinska.se
authors.forename: Giovanna
authors.initials: G
authors.lastname: Gagliardi
authors.forename: Louis S
authors.initials: LS
authors.lastname: Constine
authors.forename: Vitali
authors.initials: V
authors.lastname: Moiseenko
authors.forename: Candace
authors.initials: C
authors.lastname: Correa
authors.forename: Lori J
authors.initials: LJ
authors.lastname: Pierce
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Allen
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Marks
mesh_terms: D001943:Breast Neoplasms / Q000532:radiotherapy; D005260:Female; D006321:Heart / Q000528:radiation effects*; D006331:Heart Diseases / Q000209:etiology*; D006689:Hodgkin Disease / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008954:Models, Biological; D011832:Radiation Injuries / Q000150:complications*; D011879:Radiotherapy Dosage; D012307:Risk Factors