Diverse DNA-cleaving capacities of the jadomycins through precursor-directed biosynthesis.
Gel mobility assays were used to establish that some members of the jadomycin family of natural products act as DNA cleaving agents. Moreover, it was found that subtle structural changes generated through the use of precursor-directed biosynthesis lead to marked effects on the DNA-damaging properties of these glycosylated polyketide-derived natural products.
Cottreau
Krista M
KM
Chemistry Department, Acadia University, Wolfville, NS B4P 2R6, Canada.
Spencer
Colin
C
Wentzell
Jason R
JR
Graham
Cathy L
CL
Borissow
Charles N
CN
Jakeman
David L
DL
McFarland
Sherri A
SA
D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D053837:DNA Cleavage; D004249:DNA Damage; D007546:Isoquinolines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000378:metabolism; D013237:Stereoisomerism; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism; D013329:Structure-Activity Relationship
D007546:Isoquinolines; D009285:Naphthoquinones; C506597:jadomycin A; C081750:jadomycin B; D004247:DNA