Neoadjuvant strategies for the treatment of locally advanced esophageal cancer.
Patients with locally advanced esophageal carcinoma have consistently poor survival following surgery with associated high systemic and local-regional failure rates. Neoadjuvant therapeutic strategies have been employed in an attempt to improve outcome with variable success. Randomized trials of either neoadjuvant chemotherapy or chemoradiotherapy have shown conflicting results regarding survival and local-regional control. Future efforts should focus on identifying novel agents and targets to improve therapeutic efficacy.
Hyngstrom
John R
JR
Section of General Surgery, Department of Surgery, University of Chicago Medical Center, Chicago, Illinois 60637, USA.
Posner
Mitchell C
MC
D000970:Antineoplastic Agents / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy*; D016629:Esophagectomy; D006801:Humans; D020360:Neoadjuvant Therapy; D018714:Radiotherapy, Adjuvant
D000970:Antineoplastic Agents