Blood lipids, homocysteine, stress factors, and vitamins in clinically stable multiple sclerosis patients.
Multiple Sclerosis (MS) patients present a decrease of antioxidants and neuroprotective and immunoregulatory vitamins and an increase of total homocysteine (tHcy), cholesterol (CHL), HDL-cholesterol, and of cellular stress markers, variably associated with the different phases of the disease. We compared the blood levels of uric acid, folic acid, vitamins B12, A, and E, tHcy, CHL, HDL-cholesterol, and triglycerides in forty MS patients during a phase of clinical inactivity with those of eighty healthy controls, matched for age and sex. We found higher levels of tHcy (p = 0.032) and of HDL-cholesterol (p = 0.001) and lower levels of vitamin E (p = 0.001) and the ratio vitamin E/CHL (p = 0.001) in MS patients. In conclusion, modifications of some biochemical markers of cell damage were detected in MS patients during a phase of clinical inactivity.
Salemi
Giuseppe
G
Department of Clinical Neuroscience, University of Palermo, Palermo, Italy. gsalemi@neomedia.it
Gueli
Maria Concetta
MC
Vitale
Francesco
F
Battaglieri
Floriana
F
Guglielmini
Egidio
E
Ragonese
Paolo
P
Trentacosti
Angela
A
Massenti
Maria Fatima
MF
Savettieri
Giovanni
G
Bono
Antonino
A
D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000737:chemistry; D016022:Case-Control Studies; D005260:Female; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood; D014815:Vitamins / Q000097:blood*
D000975:Antioxidants; D008055:Lipids; D014280:Triglycerides; D014815:Vitamins; D006710:Homocysteine; D014527:Uric Acid; D005492:Folic Acid