title: Long-term efficacy of a fractional resurfacing device.
abstract: OBJECTIVE
  Recently, there has been much debate regarding the long-term efficacy of fractional resurfacing devices. While pulsed CO(2) laser resurfacing is considered a highly effective treatment, fractionated resurfacing is a newer modality and its long-term efficacy has yet to be assessed. We report the long-term outcomes of subjects previously treated with fractional CO(2) resurfacing for photodamaged skin and acne scars.
  
  
  METHODS
  Ten subjects from our previous studies who received fractional resurfacing for the treatment of acne scarring and photodamage returned for long-term follow-up visits at 1 and 2 years, respectively. Investigators graded maintenance of improvement on a quartile scale based on clinical photography.
  
  
  RESULTS
  Subjects maintained 74% of their overall improvement at their long-term visits compared to 3-month follow-up visits. While clinical improvement was maintained long-term, the results were not as remarkable as those seen at 3-month visits. The authors speculate that results seen at 3 months may be enhanced by persistent inflammatory changes, as evidenced by heat shock protein 47 activity and ongoing collagen remodeling seen in previous histologic studies. Relaxation of tightening is to be expected with any procedure along with the natural progression of aging. However, patient satisfaction was upheld long-term.
  
  
  CONCLUSIONS
  Fractional CO(2) laser resurfacing does have long-term efficacy and persistence of improvement of acne scarring and photodamage compared to baseline. However, additional treatments may be necessary to enhance long-term results.
authors.affiliation: Department of Dermatology, University of California at Irvine, Irvine, California 92697, USA.
authors.forename: Arisa E
authors.initials: AE
authors.lastname: Ortiz
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Tremaine
authors.forename: Christopher B
authors.initials: CB
authors.lastname: Zachary
mesh_terms: D000152:Acne Vulgaris / Q000150:complications* / Q000175:diagnosis; D000328:Adult; D002921:Cicatrix / Q000209:etiology / Q000601:surgery*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053685:Laser Therapy / Q000295:instrumentation*; D054020:Lasers, Gas / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012060:Rejuvenation; D018570:Risk Assessment; D015595:Skin Aging; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult