Molecular mechanisms involved in the adaptation to amino acid limitation in mammals.
In mammals, metabolic adaptations are required to cope with episodes of protein deprivation and malnutrition. Consequently, mammals have to adjust physiological functions involved in the adaptation to amino acid availability. Part of this regulation involves the modulation of the expression of numerous genes. In particular, it has been shown that amino acids by themselves can modify the expression of target genes. This review describes the regulation of amino acids homeostasis and the their role as signal molecules. The recent advances in the understanding of the molecular mechanisms involved in the control of mammalian gene expression in response to amino acid limitation will be described.
Chaveroux
Cédric
C
Unité de Nutrition Humaine, UMR 1019, INRA de Theix, 63122 Saint Genès Champanelle, France.
Lambert-Langlais
Sarah
S
Cherasse
Yoan
Y
Averous
Julien
J
Parry
Laurent
L
Carraro
Valérie
V
Jousse
Céline
C
Maurin
Anne-Catherine
AC
Bruhat
Alain
A
Fafournoux
Pierre
P
D051701:Activating Transcription Factor 4 / Q000378:metabolism; D000222:Adaptation, Physiological / Q000235:genetics; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001483:Base Sequence; D005786:Gene Expression Regulation; D006706:Homeostasis; D006801:Humans; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism
D000596:Amino Acids; D051701:Activating Transcription Factor 4; D017346:Protein Serine-Threonine Kinases