title: Programing the formation of DNA and PNA quadruplexes by pi-pi-stacking interactions.
abstract: Guanine (G) rich G(4)T(4)G(4) DNA and homologous PNA strands tend to form antiparallel dimeric quadruplexes. In contrast, the same DNA strands carrying planar aromatic 5'-residues preferentially form parallel DNA quadruplex. Conformation and composition of the DNA quadruplexes can be programed by pi-pi-stacking interaction exerted by the 5'-residues.
authors.affiliation: Department of Chemistry, Yale University, 225 Prospect Street, New Haven, CT 06520-8107, USA.
authors.forename: Sourav
authors.initials: S
authors.lastname: Saha
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Cai
authors.forename: Daniel
authors.initials: D
authors.lastname: Eiler
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hamilton
mesh_terms: D020029:Base Pairing; D001483:Base Sequence; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D054856:G-Quadruplexes; D020135:Peptide Nucleic Acids / Q000737:chemistry* / Q000235:genetics
chemical_list: D020135:Peptide Nucleic Acids; D004247:DNA