Chronic restraint stress during early Theiler's virus infection exacerbates the subsequent demyelinating disease in SJL mice: II. CNS disease severity.
Theiler's murine encephalomyelitis virus (TMEV) infection is a well-characterized model of multiple sclerosis (MS). Previous research has shown that chronic restraint stress (RS) during early TMEV infection exacerbates behavioral signs of the disease. The present data suggest that RS-induced increases in CNS inflammation, demyelination, and axonal degeneration may underlie this exacerbation. In addition, we report that males exhibit greater CNS inflammation and higher numbers of demyelinating lesions while females show greater susceptibility to RS-induced exacerbation. These findings indicate that RS during early TMEV infection increases CNS lesion formation during the late phase and suggest that the effects of RS are sex-dependent.
Young
Erin E
EE
Department of Psychology, College of Liberal Arts, Texas A&M University College Station, TX 77843, United States. e-young@tamu.edu
Sieve
Amy N
AN
Vichaya
Elisabeth G
EG
Carcoba
Luis M
LM
Young
Colin R
CR
Ambrus
Andrew
A
Storts
Ralph
R
Welsh
C Jane R
CJ
Meagher
Mary W
MW
D000818:Animals; D001369:Axons / Q000276:immunology / Q000473:pathology / Q000821:virology; D018188:Cardiovirus Infections / Q000276:immunology* / Q000503:physiopathology; D002490:Central Nervous System / Q000276:immunology* / Q000473:pathology / Q000821:virology; D002908:Chronic Disease; D020278:Demyelinating Autoimmune Diseases, CNS / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D004195:Disease Models, Animal; D018450:Disease Progression; D004679:Encephalomyelitis / Q000276:immunology* / Q000503:physiopathology / Q000821:virology; D005260:Female; D008297:Male; D051379:Mice; D009413:Nerve Fibers, Myelinated / Q000276:immunology / Q000473:pathology / Q000821:virology; D012149:Restraint, Physical / Q000009:adverse effects / Q000523:psychology; D012720:Severity of Illness Index; D012727:Sex Characteristics; D013315:Stress, Psychological / Q000276:immunology* / Q000503:physiopathology; D017945:Theilovirus / Q000276:immunology*; D014855:Wallerian Degeneration / Q000276:immunology / Q000473:pathology / Q000821:virology