title: The effect of experimental inhibition of gastric acid secretion on curd formation in abomasum and weight gain of calves.
abstract: Eight Holstein bull calves were divided into two groups; a non-treated control group and a famotidine treated group. Fresh milk was fed twice a day. The experiment was conducted between 7 and 14 days of age. During the experimental period the control group was injected with physiological saline, and the famotidine group was injected with famotidine, a histamine-H2-receptor blocker, into the jugular vein 30 minutes prior to each feeding. The control group showed maximum curd formation 2 h after feeding at both 7 and 14 days of age. Curd scores of 7-day-old and 14-day-old calves were significantly lower in the famotidine than in the control group at 2 and 4 h after feeding. Most fecal samples from the famotidine group exhibited an acidic smell. The famotidine group showed significantly lower values for both average weight gain and the rate of weight gain from 7 to 14 days of age. The inhibition of gastric acid secretion decreased curd formation in the abomasum as well as daily weight gain compared to non-treated control calves. This suggested that curd formation in the abomasum is important for the weight gain of newborn calves.
authors.affiliation: Department of Clinical Veterinary Medicine, Faculty of Agriculture, Iwate University, Morioka, Japan. keiji@iwate-u.ac.jp
authors.forename: Keiji
authors.initials: K
authors.lastname: Okada
authors.forename: Kazue
authors.initials: K
authors.lastname: Yajima
authors.forename: Takamichi
authors.initials: T
authors.lastname: Ohba
authors.forename: Tamako
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Takenori
authors.initials: T
authors.lastname: Orihashi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Sato
authors.forename: Jun
authors.initials: J
authors.lastname: Yasuda
mesh_terms: D000018:Abomasum / Q000187:drug effects* / Q000502:physiology; D000822:Animal Husbandry; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000833:Animals, Suckling; D002417:Cattle; D015738:Famotidine / Q000494:pharmacology*; D005243:Feces; D005744:Gastric Acid / Q000378:metabolism; D005766:Gastrointestinal Contents; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D007275:Injections, Intravenous; D008297:Male; D008892:Milk / Q000187:drug effects* / Q000378:metabolism; D015430:Weight Gain / Q000502:physiology*
chemical_list: D006635:Histamine H2 Antagonists; D015738:Famotidine