title: SprB is the molecular link between Salmonella pathogenicity island 1 (SPI1) and SPI4.
abstract: Salmonella pathogenicity island 1 (SPI1) and SPI4 have previously been shown to be jointly regulated. We report that SPI1 and SPI4 gene expression is linked through a transcriptional activator, SprB, encoded within SPI1 and regulated by HilA. SprB directly activates SPI4 gene expression and weakly represses SPI1 gene expression through HilD.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, IL 61801, USA.
authors.forename: Supreet
authors.initials: S
authors.lastname: Saini
authors.forename: Christopher V
authors.initials: CV
authors.lastname: Rao
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D015964:Gene Expression Regulation, Bacterial / Q000235:genetics / Q000502:physiology; D044404:Genomic Islands / Q000235:genetics / Q000502:physiology*; D016133:Polymerase Chain Reaction; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D012486:Salmonella typhimurium / Q000235:genetics* / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; C102236:HilA protein, Salmonella; C119660:HilD protein, Salmonella typhimurium; D012097:Repressor Proteins; C120885:SprB protein, Salmonella typhimurium; D015534:Trans-Activators; D014157:Transcription Factors