title: CD8 T cell cross-reactivity networks mediate heterologous immunity in human EBV and murine vaccinia virus infections.
abstract: In this study, we demonstrate complex networks of CD8 T cell cross-reactivities between influenza A virus and EBV in humans and between lymphocytic choriomeningitis virus and vaccinia virus in mice. We also show directly that cross-reactive T cells mediate protective heterologous immunity in mice. Subsets of T cell populations reactive with one epitope cross-reacted with either of several other epitopes encoded by the same or the heterologous virus. Human T cells specific to EBV-encoded BMLF1(280-288) could be cross-reactive with two influenza A virus or two other EBV epitopes. Mouse T cells specific to the vaccinia virus-encoded a11r(198-205) could be cross-reactive with three different lymphocytic choriomeningitis virus, one Pichinde virus, or one other vaccinia virus epitope. Patterns of cross-reactivity differed among individuals, reflecting the private specificities of the host's immune repertoire and divergence in the abilities of T cell populations to mediate protective immunity. Defining such cross-reactive networks between commonly encountered human pathogens may facilitate the design of vaccines.
authors.affiliation: Department of Pathology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
authors.forename: Markus
authors.initials: M
authors.lastname: Cornberg
authors.forename: Shalyn C
authors.initials: SC
authors.lastname: Clute
authors.forename: Levi B
authors.initials: LB
authors.lastname: Watkin
authors.forename: Frances M
authors.initials: FM
authors.lastname: Saccoccio
authors.forename: Sung-Kwon
authors.initials: SK
authors.lastname: Kim
authors.forename: Yuri N
authors.initials: YN
authors.lastname: Naumov
authors.forename: Michael A
authors.initials: MA
authors.lastname: Brehm
authors.forename: Nuray
authors.initials: N
authors.lastname: Aslan
authors.forename: Raymond M
authors.initials: RM
authors.lastname: Welsh
authors.forename: Liisa K
authors.initials: LK
authors.lastname: Selin
mesh_terms: D000293:Adolescent; D019264:Adoptive Transfer; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism* / Q000637:transplantation / Q000821:virology; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D018920:Coculture Techniques; D018984:Epitopes, T-Lymphocyte / Q000276:immunology / Q000378:metabolism; D020031:Epstein-Barr Virus Infections / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007111:Immunity, Cellular; D007156:Immunologic Memory; D007251:Influenza, Human / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008216:Lymphocytic Choriomeningitis / Q000276:immunology; D008297:Male; D051379:Mice; D020297:Mice, Congenic; D008810:Mice, Inbred C57BL; D014615:Vaccinia / Q000276:immunology* / Q000378:metabolism; D055815:Young Adult
chemical_list: D018984:Epitopes, T-Lymphocyte