Latest advances in innate antiviral defence.
Recent identification of key components in the pattern recognition receptor pathway of retinoic acid-inducible gene-1-like receptors, coupled with characterisation of a new cytoplasmic DNA-sensing molecule, have led to a greater understanding of the role viral nucleic acids play in activating innate immunity. This activation of type I interferon is essential for both limiting viral infection and stimulating activation of the adaptive immune response.
Irving
Aaron
A
Monash Institute of Medical Research, Monash University, P.O. Box 5418, Clayton, Victoria 3168, Australia.
Williams
Bryan Rg
BR