title: A convergent approach for the synthesis of ara-neplanocin a analogues under subzero microwave assisted conditions.
abstract: A convergent strategy for the synthesis of ara-neplanocin A analogues has been developed. Microwave assisted Mitsunobu reaction proved to be an essential tool both for the 2'-beta-hydroxy inversion and for the coupling reaction with the heterocyclic bases. The exploitation of the present approach allowed generating a family of ara-neplanocins which biological potential is still unexplored.
authors.affiliation: College of Pharmacy, The University of Georgia, Athens, Georgia, USA.
authors.forename: Marco
authors.initials: M
authors.lastname: Radi
authors.forename: Jagadeeshwar R
authors.initials: JR
authors.lastname: Rao
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Jha
authors.forename: Chung K
authors.initials: CK
authors.lastname: Chu
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry*; D008872:Microwaves
chemical_list: D000998:Antiviral Agents; C031096:neplanocin A; D000241:Adenosine