title: Rheumatoid arthritis of the craniovertebral junction.
abstract: BACKGROUND
  Rheumatoid arthritis (RA) is the most common inflammatory disease involving the spine. It has a predilection for involving the craniocervical spine. Despite widespread involvement of the cervical spine with RA, few patients need surgery. The 3 major spinal manifestations of RA in the cervical spine are basilar invagination, atlantoaxial instability, and subaxial subluxations. Surgical management of RA involving the craniovertebral junction remains a challenge despite a decline in severe cases and an improvement in surgical techniques.
  
  
  METHODS
  We conducted an exhaustive review of English-language publications discussing RA involving the craniovertebral junction. We paid special attention to publications detailing modern surgical management of these conditions. In addition, we outline our own surgical experience with such patients.
  
  
  RESULTS
  We discuss alternative surgical methods for treating basilar invagination, atlantoaxial instability, and concurrent subaxial subluxations. We detail our surgical technique for transoral odontoidectomy, occipital cervical fusion, and atlantoaxial fusion. We detail the use of spinal surgical navigation in both of these procedures.
  
  
  CONCLUSIONS
  Surgical management of RA remains a challenging field. There clearly has been a decrease in cases of mutilating RA involving the craniovertebral junction. Surgical techniques for managing these conditions have steadily improved.
authors.affiliation: Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota 55905, USA. krauss.william@mayo.edu
authors.forename: William E
authors.initials: WE
authors.lastname: Krauss
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Bledsoe
authors.forename: Michelle J
authors.initials: MJ
authors.lastname: Clarke
authors.forename: Eric W
authors.initials: EW
authors.lastname: Nottmeier
authors.forename: Mark A
authors.initials: MA
authors.lastname: Pichelmann
mesh_terms: D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D001268:Atlanto-Axial Joint / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D001269:Atlanto-Occipital Joint / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D001368:Axis, Cervical Vertebra / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D001270:Cervical Atlas / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D006801:Humans; D009777:Occipital Bone / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D011859:Radiography; D013123:Spinal Fusion / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D025241:Spondylarthritis / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*