title: Contributions of matrix metalloproteinases to neural plasticity, habituation, associative learning and drug addiction.
abstract: The premise of this paper is that increased expression of matrix metalloproteinases (MMPs) permits the reconfiguration of synaptic connections (i.e., neural plasticity) by degrading cell adhesion molecules (CAMs) designed to provide stability to those extracellular matrix (ECM) proteins that form scaffolding supporting neurons and glia. It is presumed that while these ECM proteins are weakened, and/or detached, synaptic connections can form resulting in new neural pathways. Tissue inhibitors of metalloproteinases (TIMPs) are designed to deactivate MMPs permitting the reestablishment of CAMs, thus returning the system to a reasonably fixed state. This review considers available findings concerning the roles of MMPs and TIMPs in reorganizing ECM proteins thus facilitating the neural plasticity underlying long-term potentiation (LTP), habituation, and associative learning. We conclude with a consideration of the influence of these phenomena on drug addiction, given that these same processes may be instrumental in the formation of addiction and subsequent relapse. However, our knowledge concerning the precise spatial and temporal relationships among the mechanisms of neural plasticity, habituation, associative learning, and memory consolidation is far from complete and the possibility that these phenomena mediate drug addiction is a new direction of research.
authors.affiliation: Department of Psychology, Washington State University, Pullman, WA 99164-4820, USA. wrightjw@wsu.edu
authors.forename: John W
authors.initials: JW
authors.lastname: Wright
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Harding
mesh_terms: D000818:Animals; D001245:Association Learning / Q000502:physiology*; D006185:Habituation, Psychophysiologic / Q000502:physiology*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000502:physiology*; D019966:Substance-Related Disorders / Q000201:enzymology / Q000378:metabolism*; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism
chemical_list: D019714:Tissue Inhibitor of Metalloproteinases; D020782:Matrix Metalloproteinases