Coupling reactions of hindered isonitriles and hindered alkyl thioacids: Mechanistic studies.
The coupling reaction between hindered thioacids and isonitriles is developed and described. The mechanism for the formation of the thiopyruvamide products is explored, and the method is applied to a selection of substrates.
Stockdill
Jennifer L
JL
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, NY 10065, USA.
Wu
Xiangyang
X
Danishefsky
Samuel J
SJ