Colostrinin alleviates amyloid-beta induced toxicity in rat primary hippocampal cultures.
Colostrinin (CLN), a complex mixture of proline-rich polypeptides derived from colostrums, can alleviate cognitive decline in early Alzheimer's disease patients. The molecular basis of the action of CLN has been studied in vitro using human neuroblastoma cell lines. The aim of the present study was to use quantitative immunocytochemistry and immunoblotting to investigate the ability of CLN to relieve amyloid-beta (Abeta)-induced cytotoxicity in rat primary hippocampal neuronal cells. Our data confirm that CLN alleviates the effect of Abeta-induced cytotoxicity and causes a significant reduction in the elevated levels of the antioxidant enzyme SOD1.
Froud
Kristina E
KE
Department of Life Sciences, Open University, Walton Hall, Milton Keynes, UK.
Wardhaugh
Tina
T
Banks
Duncan
D
Saffrey
M Jill
MJ
Stewart
Michael G
MG
D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D002452:Cell Count / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004622:Embryo, Mammalian; D005260:Female; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009924:Organ Culture Techniques; D010446:Peptide Fragments / Q000633:toxicity*; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D016229:Amyloid beta-Peptides; D036341:Intercellular Signaling Peptides and Proteins; D009419:Nerve Tissue Proteins; D010446:Peptide Fragments; D010455:Peptides; C075222:amyloid beta-protein (1-42); C105874:colostrinine