title: Reduced NoGo-anteriorisation during continuous performance test in deletion syndrome 22q11.2.
abstract: Deletion syndrome 22q11.2 (DS22q11.2) is a high-risk factor for psychiatric disorders. Alterations in brain morphology and function including the anterior cingulate cortex (ACC) are suggested to underlie the increased psychiatric disposition. We assessed response-inhibition in patients with DS22q11.2 (n=13) and healthy controls (n=13) matched for age, sex, and handedness by means of a Go-NoGo-Task during recording of a multi-channel electroencephalography (EEG). Analysis of event-related potentials (P300) resulted in an aberrant topographical pattern and NoGo-anteriorisation (NGA) as a parameter of medial prefrontal function was significantly reduced in patients with DS22q11.2 compared to controls. Differences in IQ between groups did not account for the findings. Source localization analysis (LORETA) revealed diminished left temporal brain activation during the Go-condition, but no altered ACC activation in DS22q11 during the NoGo-condition. Despite recent reports of structural alterations of the ACC in DS22q11.2 our findings suggest that response-inhibition mediated by the ACC is not impaired in DS22q11.2.
authors.affiliation: Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Clinic of Wuerzburg, Fuechsleinstrasse 15, 97074 Wuerzburg, Germany. Romanos@kjp.uni-wuerzburg.de
authors.forename: Marcel
authors.initials: M
authors.lastname: Romanos
authors.forename: Ann-Christine
authors.initials: AC
authors.lastname: Ehlis
authors.forename: Christina G
authors.initials: CG
authors.lastname: Baehne
authors.forename: Christian
authors.initials: C
authors.lastname: Jacob
authors.forename: Tobias J
authors.initials: TJ
authors.lastname: Renner
authors.forename: Astrid
authors.initials: A
authors.lastname: Storch
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Briegel
authors.forename: Susanne
authors.initials: S
authors.lastname: Walitza
authors.forename: Klaus-Peter
authors.initials: KP
authors.lastname: Lesch
authors.forename: Andreas J
authors.initials: AJ
authors.lastname: Fallgatter
mesh_terms: D000293:Adolescent; D001931:Brain Mapping; D016022:Case-Control Studies; D002648:Child; D002755:Choice Behavior / Q000502:physiology*; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics; D004062:DiGeorge Syndrome / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D004569:Electroencephalography / Q000379:methods; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology; D055815:Young Adult