Foamy cell angiosarcoma: a rare and deceptively bland variant of cutaneous angiosarcoma.
Cutaneous angiosarcoma can sometimes mimic other benign and malignant lesions, thereby presenting a difficult differential diagnosis. In the two cases of cutaneous angiosarcoma presented herein, extensive foamy cell alteration of tumor cells resembled a reactive xanthogranulomatous process. Foamy cell angiosarcoma is an unusual and deceptively benign morphologic variant of cutaneous angiosarcoma. Critical features for diagnosis include the presence of a deep, permeative, sometimes 'scaffolding' growth pattern and subtle areas of vascular formation.
Tatsas
Amy D
AD
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. armanda.tatsas@vanderbilt.edu
Keedy
Vicki L
VL
Florell
Scott R
SR
Simpson
Jean F
JF
Coffin
Cheryl M
CM
Kelley
Mark C
MC
Cates
Justin M M
JM
D000368:Aged; D003937:Diagnosis, Differential; D005487:Foam Cells / Q000473:pathology*; D005546:Forehead / Q000473:pathology; D006099:Granuloma / Q000473:pathology*; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006394:Hemangiosarcoma / Q000473:pathology*; D006801:Humans; D008297:Male; D012782:Shoulder / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*; D014973:Xanthomatosis / Q000473:pathology*; D055815:Young Adult