title: Multicomponent asymmetric reactions mediated by proline lithium salt.
abstract: The multicomponent reaction between proline lithium salt, 2-cyclohexen-1-one and aliphatic aldehydes affords the 4-alkylidene-2-cyclohexen-1-ones, which are interesting fragrances, and bicyclic amino acids that bear four additional stereocenters, obtained as single stereoisomer.
authors.affiliation: Dipartimento di Chimica, Università Sapienza di Roma, and Istituto di Chimica Biomolecolare del CNR, P.le Aldo Moro 5, 00185, Roma, Italy.
authors.forename: Polyssena
authors.initials: P
authors.lastname: Renzi
authors.forename: Jacob
authors.initials: J
authors.lastname: Overgaard
authors.forename: Marco
authors.initials: M
authors.lastname: Bella
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry; D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D002384:Catalysis; D003512:Cyclohexanones / Q000737:chemistry; D018020:Lithium Compounds / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry*; D012492:Salts / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000596:Amino Acids; D001643:Bridged Bicyclo Compounds; D003512:Cyclohexanones; D018020:Lithium Compounds; D012492:Salts; C028215:2-cyclohexen-1-one; D011392:Proline