title: One new guaiane-type sesquiterpene glycoside from the fruits of Daucus carota L.
abstract: A new guaiane-type sesquiterpene glycoside, torilolone 8-O-beta-D-glucopyranoside (1), together with a known analogue compound, torilolone 11-O-beta-D-glucopyranoside (2), was isolated from the fruits of Daucus carota L. Their chemical structures were elucidated on the basis of MS, NMR spectroscopic analyses coupled with chemical degradation. The cytotoxic activities of two isolated compounds were evaluated against two human gastric cancer cell lines BGC-823 and AGS using MTT assay.
authors.affiliation: College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou, P. R. China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Fu
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Tao
authors.initials: T
authors.lastname: Yi
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Feng
authors.forename: Jing-Kui
authors.initials: JK
authors.lastname: Tian
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D002236:Carbohydrate Conformation; D045744:Cell Line, Tumor; D004396:Coloring Agents; D018552:Daucus carota / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry*; D005960:Glucosides / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D045789:Sesquiterpenes, Guaiane / Q000737:chemistry* / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000188:drug therapy; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004396:Coloring Agents; D005960:Glucosides; D006027:Glycosides; D045789:Sesquiterpenes, Guaiane; D013778:Tetrazolium Salts; D013844:Thiazoles; C547965:torilolone 8-O-beta-D-glucopyranoside; C022616:thiazolyl blue