CD20cy and CD45RO immunoexpression in early rheumatoid arthritis synovium.
In this paper, we studied 15 cases of early rheumatoid arthritis presenting with inflammatory lesions in different degrees of evolution. We want to highlight B- and T-lymphocytes in synovial tissue collected from patients diagnosed with early rheumatoid arthritis, to establish the pattern of their distribution, possibly in relation to local neovascularisation to determine the role played by these types of cells. The pathological samples were represented by synovial membrane biopsy fragments, which were examined by histopathological and immunohistochemical methods. We noticed a perivascular distribution of lymphocyte infiltrate, up to formation of lymphoid follicles with germinal centers. There is a close interdependence between B- and T-lymphocytes in these lesions, and their presence in the synovial membrane in relation to newly formed blood vessels facilitates their action and their chemical mediators. Studying the interdependence of different types of lymphocytes and their connection with blood vessels may generate new therapeutic targets.
Căpitănescu
B
B
Department of Human Anatomy, University of Medicine and Pharmacy of Craiova, and Laboratory of Pathological Anatomy, Emergency County Hospital, Craiova, Romania. bogdanc26@yahoo.com
Simionescu
Cristiana
C
Stepan
A
A
Mărgăritescu
Cl
C
Georgescu
Claudia Valentina
CV
Roşu
Anca
A
D000906:Antibodies / Q000378:metabolism / Q000494:pharmacology; D018951:Antigens, CD20 / Q000276:immunology / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000378:metabolism* / Q000473:pathology; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology; D001706:Biopsy; D018450:Disease Progression; D006801:Humans; D007150:Immunohistochemistry; D017493:Leukocyte Common Antigens / Q000276:immunology / Q000378:metabolism*; D013583:Synovial Membrane / Q000378:metabolism* / Q000473:pathology; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D013997:Time Factors
D000906:Antibodies; D018951:Antigens, CD20; D017493:Leukocyte Common Antigens