title: Small bowel malignant melanoma--report of three cases and review of literature.
abstract: Malignant melanomas have a predilection to metastasize to the small bowel. Three patients with malignant melanoma involving the small bowel are reported. Two patients were operated on for small bowel obstruction and the third for gastrointestinal bleeding with anemia. Two patients remained well 6 month and 2 years, respectively, after surgery. One patient died of metastatic cerebral melanoma 6 months postoperatively. One should suspect small bowel metastasis in every patient with malignant melanoma in his past medical history, who presents with recent changes in bowel habits, intestinal obstruction or gastrointestinal bleeding. Preoperative assessment can only raise the suspicion, even with advanced imaging methods: capsule endoscopy, enteroscopy, CT or PET-CT. The only therapeutic procedure is surgical resection, offering both short term survival as well as an improvement in the quality of life. Although prognosis is dismal there are factors associated with prolonged survival: complete surgical resection with no residual primary or metastatic tumor, so-called primary small bowel tumors in patients aged more then 60 years, LDH < 200 U/L, lack of tumor spread in mesenteric lymph nodes.
authors.affiliation: First Surgical Clinic, Department of Surgery, University of Medicine and Pharmacy Gr. T. Popa Iasi, Romania. etarco@iasi.mednet.ro
authors.forename: E
authors.initials: E
authors.lastname: Târcoveanu
authors.forename: G
authors.initials: G
authors.lastname: Dimofte
authors.forename: N
authors.initials: N
authors.lastname: Dănilă
authors.forename: A
authors.initials: A
authors.lastname: Vasilescu
authors.forename: D
authors.initials: D
authors.lastname: Ferariu
authors.forename: F
authors.initials: F
authors.lastname: Crumpei
mesh_terms: D000740:Anemia / Q000209:etiology; D001932:Brain Neoplasms / Q000556:secondary; D017809:Fatal Outcome; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006801:Humans; D007414:Intestinal Neoplasms / Q000150:complications / Q000473:pathology*; D007415:Intestinal Obstruction / Q000209:etiology / Q000601:surgery; D010535:Laparoscopy; D008297:Male; D008545:Melanoma / Q000150:complications / Q000473:pathology*; D008875:Middle Aged; D011379:Prognosis; D011788:Quality of Life; D014057:Tomography, X-Ray Computed