Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain.
The in vitro activity of TR-700 (torezolid) was evaluated against a collection of 660 staphylococcal blood isolates. TR-700 showed excellent activity against all the staphylococci tested. The MIC(50) and MIC(90) values of TR-700, linezolid, daptomycin, and vancomycin against methicillin-resistant Staphylococcus aureus (MRSA) isolates were 0.25 and 0.5, 2 and 4, 0.5 and 0.5, and 1 and 2 microg/ml, respectively. TR-700 demonstrated greater in vitro potency than linezolid against staphylococci, including linezolid-resistant and vancomycin-nonsusceptible strains, and was 32-fold more active than linezolid against the seven cfr-positive MRSA strains tested.
Betriu
Carmen
C
Servicio de Microbiología Clínica, Hospital Clínico San Carlos, Madrid, Spain. cbetriu.hcsc@salud.madrid.org
Morales
Gracia
G
Rodríguez-Avial
Icíar
I
Culebras
Esther
E
Gómez
María
M
López-Fabal
Fátima
F
Picazo
Juan J
JJ
D000081:Acetamides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017576:Daptomycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial / Q000187:drug effects; D066298:In Vitro Techniques; D000069349:Linezolid; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D023303:Oxazolidinones / Q000494:pharmacology*; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology; D013030:Spain; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D013777:Tetrazoles / Q000494:pharmacology*; D014640:Vancomycin / Q000494:pharmacology
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D013777:Tetrazoles; D014640:Vancomycin; C546016:tedizolid; D000069349:Linezolid; D017576:Daptomycin