Synthesis and antimicrobial activities of novel biologically active heterocycles: 10h-phenothiazines, their ribofuranosides, and sulfone derivatives.
This article deals with the synthesis and antimicrobial activity of a series of novel substituted 10H-phenothiazines, their ribofuranosides, and sulfone derivatives. 10H-Phenothiazines were prepared by Smiles rearrangement. These prepared phenothiazines were used as the base to prepare ribofuranosides by treatment with sugar (1-O-acetyl-2,3,5-tri-O-benzoylribofuranose). Sulfone derivatives were prepared by the oxidation of 10H-phenothiazines. The structure of the synthesized compounds was established by elemental analysis and spectroscopic data.
Dixit
Yogesh
Y
Department of Chemistry, University of Rajasthan, Jaipur, India. yogeshdixit15@yahoo.co.in
Dixit
Rahul
R
Gautam
Naveen
N
Gautam
D C
DC
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001231:Aspergillus flavus / Q000187:drug effects; D001234:Aspergillus niger / Q000187:drug effects; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010640:Phenothiazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011549:Pseudomonas / Q000187:drug effects; D012266:Ribose / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects; D013450:Sulfones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005663:Furans; D006571:Heterocyclic Compounds; D009705:Nucleosides; D010640:Phenothiazines; D013450:Sulfones; D012266:Ribose