Ionic liquid-assisted transdermal delivery of sparingly soluble drugs.
We report the first successful application of a novel IL-assisted non-aqueous microemulsion stabilized by a blend of two nontoxic surfactants, polyoxyethylene sorbitan monooleate (Tween-80), and sorbitan laurate (Span-20) for transdermal delivery of acyclovir, which is insoluble or sparingly soluble in water and most common organic liquids.
Moniruzzaman
Muhammad
M
Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Moto-oka, Fukuoka 819-0395, Japan.
Tahara
Yoshiro
Y
Tamura
Miki
M
Kamiya
Noriho
N
Goto
Masahiro
M
D000212:Acyclovir / Q000008:administration & dosage*; D000279:Administration, Cutaneous; D000818:Animals; D016503:Drug Delivery Systems; D006601:Hexoses / Q000737:chemistry; D052578:Ionic Liquids / Q000737:chemistry*; D011136:Polysorbates / Q000737:chemistry; D014867:Water / Q000737:chemistry
D006601:Hexoses; D052578:Ionic Liquids; D011136:Polysorbates; D014867:Water; C014822:sorbitan monolaurate; D000212:Acyclovir