Administration of intravenous albumin around the time of oocyte retrieval reduces pregnancy rate without preventing ovarian hyperstimulation syndrome: a systematic review and meta-analysis.
OBJECTIVE
The aim of this meta-analysis was to evaluate whether IV albumin infusion around the time of oocyte retrieval prevents ovarian hyperstimulation syndrome (OHSS) and affects the pregnancy rate.


METHODS
A meta-analysis of data from 9 randomized controlled trials including 1,613 women at high risk for developing OHSS in in vitro fertilization cycles was performed.


RESULTS
The combined incidence of severe OHSS was 6.0% in the IV albumin group and 7.9% in saline or no treatment groups. These rates were statistically not different (RR = 0.80, 95% CI = 0.57-1.12). Treatment with IV albumin significantly lowered the pregnancy rates (RR = 0.85, 95% CI = 0.74-0.98).


CONCLUSIONS
The combined data presented in this meta-analysis do not support a benefit for IV albumin around the time of oocyte retrieval in preventing OHSS and even showed a deleterious effect on the pregnancy rate.
Jee
Byung Chul
BC
Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Bundang Seongnam, Gyeonggi, Korea.
Suh
Chang Suk
CS
Kim
Yong Beom
YB
Kim
Seok Hyun
SH
Choi
Young Min
YM
Kim
Jung Gu
JG
Moon
Shin Yong
SY
D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D054315:Oocyte Retrieval / Q000379:methods*; D016471:Ovarian Hyperstimulation Syndrome / Q000188:drug therapy* / Q000517:prevention & control*; D011247:Pregnancy; D018873:Pregnancy Rate; D012709:Serum Albumin / Q000008:administration & dosage*; D017211:Treatment Failure
D012709:Serum Albumin