Isolation of an antileishmanial and antitrypanosomal flavanone from the leaves of Baccharis retusa DC. (Asteraceae).
In the course of selection of new bioactive compounds from Brazilian flora, the crude MeOH extract from the leaves of Baccharis retusa DC. (Asteraceae) showed potential against Leishmania sp. and Trypanosoma cruzi. Chromatographic fractionation of the dichloromethane phase from MeOH extract yielded great amounts of the bioactive derivative, which was characterized as 5,6,7-trihydroxy-4'-methoxyflavanone. The structure of this compound was established on the basis of spectroscopic data analysis, mainly nuclear magnetic resonance and mass spectrometry.
Grecco
Simone S
SS
Departamento de Ciências Exatas e da Terra, Universidade Federal de São Paulo-Campus Diadema, 09972-270, Diadema, São Paulo, Brazil.
Reimão
Juliana Q
JQ
Tempone
Andre G
AG
Sartorelli
Patricia
P
Romoff
Paulete
P
Ferreira
Marcelo J P
MJ
Fávero
Oriana A
OA
Lago
Joao H G
JH
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D031175:Baccharis / Q000737:chemistry*; D001938:Brazil; D002478:Cells, Cultured; D005591:Chemical Fractionation; D002853:Chromatography, Liquid; D044950:Flavanones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007891:Leishmania / Q000187:drug effects*; D008253:Macaca mulatta; D008264:Macrophages / Q000469:parasitology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008807:Mice, Inbred BALB C; D009000:Monocytes / Q000469:parasitology; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D014349:Trypanosoma cruzi / Q000187:drug effects*
D000981:Antiprotozoal Agents; D044950:Flavanones; D010936:Plant Extracts; C028610:flavanone