title: [Pharmacokinetics of essentiale N].
abstract: The optimum time of exposure of the Essentiale N hepatoprotector with an erythrocyte-leukocyte suspension has been determined in vitro using the blood of healthy donors. Variation of the drug distribution in the blood depending on the exposure time was studied by the method of UV absorption spectroscopy. It is established that the optimum exposure of Essentiale N with an erythrocyte-leukocyte suspension is about 10 min. This corresponds to a minimum concentration of Essentiale N in the supernatant phase, which is evidence for the maximum saturation of the cell composition by the preparation. At the same time, the degree of hemolysis does not exceed the normal physiological level.
authors.forename: D D
authors.initials: DD
authors.lastname: Morikov
authors.forename: V I
authors.initials: VI
authors.lastname: Gorbachev
authors.forename: V V
authors.initials: VV
authors.lastname: Dvornichenko
authors.forename: V A
authors.initials: VA
authors.lastname: Semibratova
authors.forename: S A
authors.initials: SA
authors.lastname: Mikhaĭlov
mesh_terms: D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000378:metabolism; D010713:Phosphatidylcholines / Q000097:blood / Q000493:pharmacokinetics*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D010713:Phosphatidylcholines; C011246:essential 303 forte