title: Evaluation of penicillin G potassium troches in the treatment of minor recurrent aphthous ulceration in a Chinese cohort: a randomized, double-blinded, placebo and no-treatment-controlled, multicenter clinical trial.
abstract: OBJECTIVE
  The aim of this study was to explore the effectiveness and safety of topical application of 50 mg penicillin G potassium troches in the treatment of minor recurrent aphthous ulcerations (MiRAU) in a Chinese cohort.
  
  
  METHODS
  A randomized, double-blinded, placebo and no-treatment-controlled, multicenter clinical trial was performed. Troches were consecutively applied 4 times per day for 4 days. The size and pain level of ulcers were measured and recorded on days 0, 3, 4, 5, and 6.
  
  
  RESULTS
  A total of 258 subjects with minor recurrent aphthous ulcerations (86 subjects in penicillin G potassium group, 88 subjects in placebo control group, and 84 subjects in no-treatment control group) fulfilled the study. Penicillin G potassium significantly reduced ulcer size (P < .00001 for days 3, 4, 5, and 6) and alleviated ulcer pain (P < .00001 for days 3, 4, 5, and 6). No severe adverse reactions were observed. Only 4 subjects experienced mild adverse reaction.
  
  
  CONCLUSIONS
  Penicillin G potassium troches are effective in reducing ulcer size and alleviating ulcer pain of the patients in the treatment of a single episode of MiRAU in this Chinese cohort. Few adverse effects were observed with this therapeutic approach.
authors.affiliation: State Key Laboratory of Oral Disease, West China College of Stomatology, Sichuan University, Sichuan, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhou
authors.forename: Qiaming
authors.initials: Q
authors.lastname: Chen
authors.forename: Wenxia
authors.initials: W
authors.lastname: Meng
authors.forename: Lu
authors.initials: L
authors.lastname: Jiang
authors.forename: Zhi
authors.initials: Z
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Liu
authors.forename: Mei
authors.initials: M
authors.lastname: Lin
authors.forename: Hongmei
authors.initials: H
authors.lastname: Zhou
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Chen
authors.forename: Man
authors.initials: M
authors.lastname: Zhao
authors.forename: Xin
authors.initials: X
authors.lastname: Zeng
mesh_terms: D000278:Administration, Buccal; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D002681:China; D015331:Cohort Studies; D004311:Double-Blind Method; D004890:Erythema / Q000139:chemically induced; D005260:Female; D005500:Follow-Up Studies; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008297:Male; D010147:Pain Measurement; D010400:Penicillin G / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D010919:Placebos; D012008:Recurrence; D013281:Stomatitis, Aphthous / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D010919:Placebos; D010400:Penicillin G