How activity of inflammatory bowel disease influences bone loss.
Bone loss is a common problem for individuals with inflammatory bowel disease (IBD). The aim of our study was to assess bone mineral density (BMD) in patients with IBD and to investigate the role of corticosteroid (CS) use and duration and activity of disease on BMD. Ninety-two patients (56 men and 36 women) with IBD, of whom 32 had ulcerative colitis (UC) and 60 had Crohn's disease (CD), underwent clinical assessment. Lumbar and femoral neck BMDs were measured by dual-energy X-ray absorptiometry. Osteopenia was observed in 14 patients (43%) with UC and in 24 patients (40%) with CD (p=0.187). Four patients (12%) with UC and 7 patients (11%) with CD had osteoporosis (p=0.308). Femoral BMD decreased in patients with long duration of CS use and correlated inversely with disease activity. Multiple regression analysis of BMD showed that statistically significant risk factors were duration of active disease and body mass index as well. Based on our results, it is necessary to take into account the risk of decreased BMD in patients with IBD. It is most important to achieve disease remission as soon as possible in addition to nutritional support.
Orlic
Zeljka Crncevic
ZC
Department of Endocrinology, Diabetes and Metabolic Diseases, Clinical Hospital Centre Rijeka, Rijeka, Croatia. Electronic address: zeljka.crncevic@ri.t-com.hr.
Turk
Tamara
T
Department of Endocrinology, Diabetes and Metabolic Diseases, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
Sincic
Brankica Mijandrusic
BM
Department of Gastroenterology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
Stimac
Davor
D
Department of Gastroenterology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
Cvijanovic
Olga
O
Department of Anatomy, Medical School, University of Rijeka, Rijeka, Croatia.
Maric
Ivana
I
Department of Anatomy, Medical School, University of Rijeka, Rijeka, Croatia.
Tomas
Maja Ilic
MI
Department of Physiology and Immunology, University of Rijeka, Rijeka, Croatia.
Jurisic-Erzen
Dubravka
D
Department of Endocrinology, Diabetes and Metabolic Diseases, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
Licul
Vanja
V
Department of Gastroenterology, Clinical Hospital Centre Rijeka, Rijeka, Croatia.
Bobinac
Dragica
D
Department of Anatomy, Medical School, University of Rijeka, Rijeka, Croatia.
D015502:Absorptiometry, Photon / Q000379:methods*; D000328:Adult; D000368:Aged; D015519:Bone Density; D001862:Bone Resorption / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism; D018450:Disease Progression; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000378:metabolism; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000378:metabolism; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors; D055815:Young Adult