title: Tau kinase I overexpression induces dentate gyrus degeneration.
abstract: Familial Alzheimer gene mutations result in a signaling mechanism that converges, downstream, in the activation of GSK3 activity. We have generated a GSK3 transgenic mouse model to study the consequences of GSK3 activation. In this model, dentate gyrus is degenerated in a process in which phosphorylated tau can be involved.
authors.affiliation: Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Universidad Autónoma de Madrid, Madrid, Spain. javila@cbm.uam.es
authors.forename: Jesús
authors.initials: J
authors.lastname: Avila
authors.forename: Elena
authors.initials: E
authors.lastname: Gómez de Barreda
authors.forename: Tobias
authors.initials: T
authors.lastname: Engel
authors.forename: Mar
authors.initials: M
authors.lastname: Pérez
authors.forename: Patricia
authors.initials: P
authors.lastname: Martín-Maestro
authors.forename: Almudena
authors.initials: A
authors.lastname: Fuster-Matanzo
authors.forename: Paloma
authors.initials: P
authors.lastname: Goñi-Oliver
authors.forename: José J
authors.initials: JJ
authors.lastname: Lucas
authors.forename: Félix
authors.initials: F
authors.lastname: Hernández
mesh_terms: D000818:Animals; D018891:Dentate Gyrus / Q000201:enzymology* / Q000473:pathology; D004195:Disease Models, Animal; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics*; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D019636:Neurodegenerative Diseases / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: C054369:MAPT protein, human; D016875:tau Proteins; D038362:Glycogen Synthase Kinase 3