title: Cortical dopamine D2/D3 receptors and verbal memory in man.
abstract: BACKGROUND
  It has been previously reported that hippocampal dopamine D2/D3 receptors are involved in the regulation of verbal memory and learning in healthy volunteers. We tested this hypothesis further and studied whether cortical dopamine D2/D3 receptor availability in vivo is associated with verbal memory as assessed with the revised Wechsler Memory Scale (WMS-R).
  
  
  METHODS
  Forty healthy Finnish subjects were evaluated according to the WMS-R and scanned with positron emission tomography (PET) and dopamine D2/D3 receptor radioligand [(11)C]FLB457 for the measurement of cortical D2/D3 receptor binding.
  
  
  RESULTS
  WMS-R verbal memory and learning parameters did not significantly correlate with D2/D3 receptor binding potential (BP(ND)) in the studied cortical regions.
  
  
  CONCLUSIONS
  Our findings do not support a major role for cortical D2/D3 receptors in the regulation of verbal memory in healthy individuals.
authors.affiliation: Turku PET Centre, Turku University Hospital, 20521 Turku, Finland.
authors.forename: Ville
authors.initials: V
authors.lastname: Lumme
authors.forename: Mika M
authors.initials: MM
authors.lastname: Hirvonen
authors.forename: Tuula
authors.initials: T
authors.lastname: Ilonen
authors.forename: Jussi
authors.initials: J
authors.lastname: Hirvonen
authors.forename: Kjell
authors.initials: K
authors.lastname: Någren
authors.forename: Jarmo
authors.initials: J
authors.lastname: Hietala
mesh_terms: D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology*; D008875:Middle Aged; D049268:Positron-Emission Tomography; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D050637:Receptors, Dopamine D3 / Q000378:metabolism*; D014705:Verbal Behavior / Q000502:physiology*; D055815:Young Adult
chemical_list: D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3