title: IgE, mast cells, basophils, and eosinophils.
abstract: IgE, mast cells, basophils, and eosinophils are essential components of allergic inflammation. Antigen-specific IgE production, with subsequent fixation of IgE to FcepsilonRI receptors on mast cells and basophils, is central to the initiation and propagation of immediate hypersensitivity reactions. Mast cells, basophils, and eosinophils are central effector cells in allergic inflammation, as well as in innate and adaptive immunity. This review highlights what is known about these components and their roles in disease pathogenesis.
authors.affiliation: Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1881, USA.
authors.forename: Kelly D
authors.initials: KD
authors.lastname: Stone
authors.forename: Calman
authors.initials: C
authors.lastname: Prussin
authors.forename: Dean D
authors.initials: DD
authors.lastname: Metcalfe
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D001491:Basophils / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D015415:Biomarkers / Q000378:metabolism; D015550:Cell Degranulation; D002454:Cell Differentiation; D002465:Cell Movement; D016207:Cytokines / Q000378:metabolism; D004804:Eosinophils / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy; D007073:Immunoglobulin E / Q000276:immunology / Q000378:metabolism*; D008407:Mast Cells / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D000069444:Omalizumab; D017455:Receptors, IgE / Q000276:immunology; D053802:Tryptases / Q000097:blood
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D015415:Biomarkers; D016207:Cytokines; D017455:Receptors, IgE; D000069444:Omalizumab; D007073:Immunoglobulin E; D053802:Tryptases