title: Foamy cell angiosarcoma: a rare and deceptively bland variant of cutaneous angiosarcoma.
abstract: Cutaneous angiosarcoma can sometimes mimic other benign and malignant lesions, thereby presenting a difficult differential diagnosis. In the two cases of cutaneous angiosarcoma presented herein, extensive foamy cell alteration of tumor cells resembled a reactive xanthogranulomatous process. Foamy cell angiosarcoma is an unusual and deceptively benign morphologic variant of cutaneous angiosarcoma. Critical features for diagnosis include the presence of a deep, permeative, sometimes 'scaffolding' growth pattern and subtle areas of vascular formation.
authors.affiliation: Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA. armanda.tatsas@vanderbilt.edu
authors.forename: Amy D
authors.initials: AD
authors.lastname: Tatsas
authors.forename: Vicki L
authors.initials: VL
authors.lastname: Keedy
authors.forename: Scott R
authors.initials: SR
authors.lastname: Florell
authors.forename: Jean F
authors.initials: JF
authors.lastname: Simpson
authors.forename: Cheryl M
authors.initials: CM
authors.lastname: Coffin
authors.forename: Mark C
authors.initials: MC
authors.lastname: Kelley
authors.forename: Justin M M
authors.initials: JM
authors.lastname: Cates
mesh_terms: D000368:Aged; D003937:Diagnosis, Differential; D005487:Foam Cells / Q000473:pathology*; D005546:Forehead / Q000473:pathology; D006099:Granuloma / Q000473:pathology*; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006394:Hemangiosarcoma / Q000473:pathology*; D006801:Humans; D008297:Male; D012782:Shoulder / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*; D014973:Xanthomatosis / Q000473:pathology*; D055815:Young Adult