title: Synthesis of 2'-N-formamido nucleosides and biological evaluation.
abstract: The 2'-N-formamide derivatives of adenosine, cytidine, and 9-beta-d-arabinofuranosyladenine were synthesized and tested (as triphosphate) for their substrate capacities for the HCV NS5B polymerase.
authors.affiliation: Laboratory of Medicinal Chemistry, Rega Institute for Medical Research, Leuven, Belgium.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Abramov
authors.forename: Marleen
authors.initials: M
authors.lastname: Renders
authors.forename: Piet
authors.initials: P
authors.lastname: Herdewijn
mesh_terms: D000577:Amides / Q000737:chemistry*; D001483:Base Sequence; D005561:Formates / Q000737:chemistry*; D016174:Hepacivirus / Q000187:drug effects*; D006526:Hepatitis C / Q000188:drug therapy*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000577:Amides; D005561:Formates; D009705:Nucleosides; C030544:formic acid