title: Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.
abstract: Drug rash with eosinophilia and systemic symptoms (DRESS), also known as drug-induced hypersensitivity syndrome (DIHS), is a severe adverse drug reaction affecting multiple organs caused by drug treatment. The current report describes a man who was prescribed zonisamide for epilepsy and subsequently developed widespread skin rash, acute kidney injury, high-grade fever, eosinophilia, liver dysfunction, lymphadenopathy and an increase in antihuman herpesvirus-6 immunoglobulin G titer. Hypersensitivity to zonisamide was confirmed by the skin patch test. Based on these findings, the patient was diagnosed with DRESS/DIHS caused by zonisamide. This is the first report of acute kidney injury due to zonisamide-induced DRESS/DIHS.
authors.affiliation: Department of Nephrology and Rheumatology, Toyota Memorial Hospital. hujita@ff.iij4u.or.jp
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Fujita
authors.forename: Midori
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Kuihiro
authors.initials: K
authors.lastname: Nabeshima
authors.forename: Makoto
authors.initials: M
authors.lastname: Tomita
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Murakami
authors.forename: Shigeru
authors.initials: S
authors.lastname: Nakai
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamakita
authors.forename: Kayoko
authors.initials: K
authors.lastname: Matsunaga
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology*; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D004827:Epilepsy / Q000188:drug therapy; D005076:Exanthema / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007555:Isoxazoles / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D010328:Patch Tests; D016896:Treatment Outcome; D000078305:Zonisamide
chemical_list: D000305:Adrenal Cortex Hormones; D000927:Anticonvulsants; D007555:Isoxazoles; D000078305:Zonisamide