title: Capnocytophaga canimorsus infections in The Netherlands: a nationwide survey.
abstract: A retrospective nationwide survey on the occurrence of Capnocytophaga canimorsus and Capnocytopaga cynodegmi infections in The Netherlands over 3 years showed 32 cases, of which 31 were caused by C. canimorsus and one by an unspecified oxidase-positive Capnocytophaga strain. Twenty-eight patients had been diagnosed by blood culture, one by culture from both blood and cerebrospinal fluid (CSF), one by culture from a conjunctival swab, and two patients by 16S rRNA gene amplification by PCR directly from a blood or CSF specimen. The incidence rate was 0.67 infections per million population. Bacteraemia was found in 94% of the cases. The age range of patients was 38-80 years; 72% of them were male. Among 26 patients from whom clinical data were available, splenectomy was not reported, but alcoholism was reported in five. Nine patients (35%) had been admitted to the intensive-care unit, and three patients (13%) died. The mortality rate was much lower than observed in previous studies.
authors.affiliation: Department of Medical Microbiology, Leiden University Medical Centre, Leiden, The Netherlands. a.p.vandam@olvg.nl
authors.forename: A P
authors.initials: AP
authors.lastname: van Dam
authors.forename: A
authors.initials: A
authors.lastname: Jansz
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001431:Bacteriological Techniques / Q000379:methods; D001769:Blood / Q000382:microbiology; D002206:Capnocytophaga / Q000145:classification / Q000302:isolation & purification*; D002555:Cerebrospinal Fluid / Q000382:microbiology; D003228:Conjunctiva / Q000382:microbiology; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000453:epidemiology* / Q000382:microbiology* / Q000401:mortality; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D016133:Polymerase Chain Reaction / Q000379:methods; D012329:RNA, Bacterial / Q000235:genetics; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012189:Retrospective Studies; D017678:Sex Distribution
chemical_list: D012329:RNA, Bacterial; D012336:RNA, Ribosomal, 16S