Stochasticity in staged models of epidemics: quantifying the dynamics of whooping cough.
Although many stochastic models can accurately capture the qualitative epidemic patterns of many childhood diseases, there is still considerable discussion concerning the basic mechanisms generating these patterns; much of this stems from the use of deterministic models to try to understand stochastic simulations. We argue that a systematic method of analysing models of the spread of childhood diseases is required in order to consistently separate out the effects of demographic stochasticity, external forcing and modelling choices. Such a technique is provided by formulating the models as master equations and using the van Kampen system-size expansion to provide analytical expressions for quantities of interest. We apply this method to the susceptible-exposed-infected-recovered (SEIR) model with distributed exposed and infectious periods and calculate the form that stochastic oscillations take on in terms of the model parameters. With the use of a suitable approximation, we apply the formalism to analyse a model of whooping cough which includes seasonal forcing. This allows us to more accurately interpret the results of simulations and to make a more quantitative assessment of the predictions of the model. We show that the observed dynamics are a result of a macroscopic limit cycle induced by the external forcing and resonant stochastic oscillations about this cycle.
Black
Andrew J
AJ
Theoretical Physics Group, School of Physics and Astronomy, University of Manchester, Manchester M13 9PL, UK.
McKane
Alan J
AJ
D002648:Child; D003141:Communicable Diseases / Q000453:epidemiology*; D004196:Disease Outbreaks; D004198:Disease Susceptibility / Q000453:epidemiology; D006801:Humans; D008954:Models, Biological; D014917:Whooping Cough / Q000453:epidemiology*