Control of cell shape and plasticity during development and disease by the actin-binding protein Drebrin.
Drebrin is an actin-binding protein, originally identified in neuronal cells, involved in the regulation of actin filament organisation, especially during the formation of neurites and cell protrusions of motile cells. Drebrin is found in diverse non-neuronal cells, primarily in association with cell processes and intercellular junctions where it again plays a key role in actin remodelling. The downregulation of Drebrin in Alzheimer's Disease and Down Syndrome and conversely its upregulation in various carcinomas indicate that Drebrin is an important component of the pathogenesis of multiple diseases.
Dun
Xin-peng
XP
Institute of Biomedical and Clinical Science, Peninsula Medical School, University of Plymouth, Plymouth PL6 8BU, United Kingdom.
Chilton
John K
JK
D000199:Actins / Q000235:genetics* / Q000378:metabolism; D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D048430:Cell Shape / Q000502:physiology*; D004195:Disease Models, Animal; D004314:Down Syndrome / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D009479:Neuropeptides / Q000502:physiology*; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs / Q000235:genetics
D000199:Actins; D009479:Neuropeptides; C053386:drebrins