Beneficial dexa-related effects of natural polyphenols on experimentally-induced diabetes mellitus complications.
The benefits of the proanthocyanidins, polyphenols extracted from black grapes seeds, have been shown by using as experimental model, namely streptozotocin-induced diabetes mellitus on Wistar white rats.


METHODS
Streptozotocin was administered in a single intraperitoneal dose of 60 mg/Kg body mass. Vegetal polyphenols were administered as water solution, in a dose of 0.028 mg/Kg body mass, p.o. (through tube feeding), every two days, for a period of 16 weeks. We performed DEXA bone mineral density tests, in order to determine BDM (bone mineral density in g/cm2), BMC (body mass index expressed in g) and fat (%Fat) in control and diabetic animals, before and after polyphenol delivery.


RESULTS
The evolution of bone mineral density depending on the area, in diabetic males, measured from the beginning to the end of the experiment, has shown a significant decrease, especially in the femur area. In diabetic males that received polyphenol treatment, these differences are statistically minimum. Bone mineral density depending on the area showed the highest differences in the spine, followed by the cervical spine. In diabetic males that received polyphenol treatment, we noticed a 4-7% decrease of their body fat as compared to the beginning of the experiment, for all the analyzed samples. As for the spine, the highest BMC difference depending on the area was found in diabetic males with polyphenol intake, and the overall highest difference was noticed in diabetic males. The body fat index we studied in the male groups was the lowest in the diabetic males.


CONCLUSIONS
Osteoporosis regression due to polyphenols proves the benefits of proanthoyianidins used treating the chronic complications of diabetes mellitus.
Pohaci
C
C
School of Medicine, Department of Pathophysiology, "Gr.T. Popa" University of Medicine and Pharmacy Iaşi.
Groza
Marinela
M
Mareş
Laura
L
Ciocoiu
Manuela
M
Bădescu
Magda
M
D015502:Absorptiometry, Photon; D000818:Animals; D015992:Body Mass Index; D015519:Bone Density / Q000187:drug effects*; D048909:Diabetes Complications / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control*; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000188:drug therapy* / Q000378:metabolism; D005269:Femur / Q000187:drug effects; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use*; D008159:Lumbar Vertebrae / Q000187:drug effects; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D010636:Phenols / Q000494:pharmacology* / Q000627:therapeutic use*; D059808:Polyphenols; D051381:Rats; D017208:Rats, Wistar; D013131:Spine / Q000187:drug effects
D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols