title: Xylan from corn cobs, a promising polymer for drug delivery: production and characterization.
abstract: Although many authors have reported several beneficial effects ascribed to xylan, such as inhibitory action on mutagenicity activity, antiphlogistic effects, and mitogenic and comitogenic activities, few papers have investigated a systematic study on the technological properties of this polymer. The aim of the present work was to evaluate xylan as a promise raw material for the pharmaceutical industry. The water-insoluble xylan samples were extracted from corn cobs following several steps. The obtained powered sample was analyzed by infrared and RMN spectroscopy, and characterized regarding their particle size, bulk and tap densities, compressibility index, compactability, Hausner ratio, and angle of repose. According to the results, infrared and RMN spectroscopy were shown to be able to evaluate the xylan structural conformation and composition, respectively. In addition, rheological data demonstrated that xylan powder obtained from corn cobs may be characterized as a material with low density and very cohesive flow properties.
authors.affiliation: Universidade Federal do Rio Grande do Norte, Natal, R, Brazil.
authors.forename: Elquio Eleamen
authors.initials: EE
authors.lastname: Oliveira
authors.forename: Acarília Eduardo
authors.initials: AE
authors.lastname: Silva
authors.forename: Toshiyuki Nagashima
authors.initials: TN
authors.lastname: Júnior
authors.forename: Monique Christine Salgado
authors.initials: MC
authors.lastname: Gomes
authors.forename: Larissa Muratori
authors.initials: LM
authors.lastname: Aguiar
authors.forename: Henrique Rodrigues
authors.initials: HR
authors.lastname: Marcelino
authors.forename: Ivonete Batista
authors.initials: IB
authors.lastname: Araújo
authors.forename: Marc P
authors.initials: MP
authors.lastname: Bayer
authors.forename: Nágila M P S
authors.initials: NM
authors.lastname: Ricardo
authors.forename: Anselmo Gomes
authors.initials: AG
authors.lastname: Oliveira
authors.forename: Eryvaldo Sócrates Tabosa
authors.initials: ES
authors.lastname: Egito
mesh_terms: D001709:Biotechnology / Q000379:methods; D004337:Drug Carriers; D016503:Drug Delivery Systems; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008855:Microscopy, Electron, Scanning / Q000379:methods; D009153:Mutagens; D010316:Particle Size; D011108:Polymers; D011208:Powders; D012212:Rheology / Q000379:methods; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods; D014990:Xylans / Q000737:chemistry; D003313:Zea mays / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D009153:Mutagens; D011108:Polymers; D011208:Powders; D014990:Xylans