title: [MTHFR gene polymorphism and male infertility].
abstract: Unexplained male infertility is mostly due to sperm-related gene mutations in the spermatogenic process. Methylenetetrahydrofolate reductase (MTHFR) plays an important role in the process of DNA, RNA and protein metabolism, and is closely related with spermatogenesis. Researchers have found more than 20 single nucleotide polymorphisms (SNP) of the MTHFR gene. The polymorphisms of MTHFRC677T and A1298C may have a close relationship with male infertility. But the correlation between MTHFRG1793 and male infertility needs to be further studied.
authors.affiliation: Department of Reproduction Regulation, Beijing Obstetrics and Gynecology Hospital Affiliated to Capital Medical University, Beijing 100026, China. lishanshan309@yahoo.com.cn
authors.forename: Shan-Shan
authors.initials: SS
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Li
mesh_terms: D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)