Reining in H(2)O(2) for safe signaling.
Mammalian cells use hydrogen peroxide (H(2)O(2)) not only to kill invading pathogens, but also as a signaling modulator. Woo et al. (2010) now show that the local inactivation of a H(2)O(2)-degrading enzyme ensures that the production of this oxidant is restricted to the signaling site.
Toledano
Michel B
MB
DSV, IBITECS, Laboratoire Stress Oxydants et Cancer, CEA-Saclay, Gif-sur-Yvette, France. michel.toledano@cea.fr
Planson
Anne-Gaëlle
AG
Delaunay-Moisan
Agnès
A
D000818:Animals; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D051379:Mice; D054464:Peroxiredoxins / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction
D006861:Hydrogen Peroxide; D054464:Peroxiredoxins; D020794:Receptor Protein-Tyrosine Kinases