Brine shrimp toxicity evaluation of some Tanzanian plants used traditionally for the treatment of fungal infections.
Plants which are used by traditional healers in Tanzania have been evaluated to obtain preliminary data of their toxicity using the brine shrimps test. The results indicate that 9 out of 44 plant species whose extracts were tested exhibited high toxicity with LC(50) values below 20 microg/ml. These include Aloe lateritia Engl. (Aloaceae) [19.1 microg/ml], Cassia abbreviata Oliv. (Caesalpiniaceae) [12.7 microg/ml], Croton scheffleri Pax (Euphorbiaceae) [13.7 microg/ml], Hymenodactyon parvifolium Brig (Rubiaceae) [13.4 microg/ml], Kigelia Africana L. (Bignoniaceae) [7.2 microg/ml], and Ocimum suave Oliv. (Labiatae) [16.7 microg/ml]. Twelve plants gave LC(50) values between 21 and 50 microg/ml, 11 plants gave LC(50) values between 50 and 100 microg/ml, and 18 plants gave LC(50) values greater than 100 microg/ml.
Moshi
Mainen J
MJ
Institute of Traditional Medicine, Muhimbili University College of Health Sciences, Dar es Salaam, Tanzania. mmoshi@muchs.ac.tz
van den Beukel
Carolien J P
CJ
Hamza
Omar J M
OJ
Mbwambo
Zakaria H
ZH
Nondo
Ramadhani O S
RO
Masimba
Pax J
PJ
Matee
Mecky I N
MI
Kapingu
Modest C
MC
Mikx
Frans
F
Verweij
Paul E
PE
van der Ven
André J A M
AJ