Tocopheryl quinones and mitochondria.
In the past, the role of tocopherols and tocopheryl hydroquinones as antioxidants in mitochondria has been examined. However, structural properties of tocopherols and tocopheryl quinones (arrangement of polar/apolar moieties) have also been recognized as being crucial for the selective transport of RRR-alpha-congeners compared with other tocopherols in the cell, suggesting that these properties might be generally important for the binding of vitamin E-related compounds to proteins and enzymes in mitochondria. Therefore, direct modulation of mitochondrial activities, such as bioenergetics, production of reactive oxygen species and apoptosis, not exclusively related to the redox activity of these compounds is increasingly studied. This overview focuses on the influence of alpha-/gamma-tocopheryl quinones and their parent alpha-/gamma-tocopherols on mitochondrial functions, including formation of tocopheryl quinones, their analytical aspects, their potential as alternative substrates and their inhibitory activity for some mitochondrial functions. It is shown that the understanding of how tocopheryl quinones and tocopherols interfere with mitochondrial functions on the molecular level is still incomplete and that a better comprehension requires further research activities.
Gille
Lars
L
Molecular Pharmacology and Toxicology Unit, Department of Biomedical Sciences, University of Veterinary Medicine Vienna, Vienna, Austria. Lars.Gille@vetmeduni.ac.at
Staniek
Katrin
K
Rosenau
Thomas
T
Duvigneau
J Catharina
JC
Kozlov
Andrey V
AV
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004579:Electron Transport; D004583:Electrons; D005609:Free Radicals / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D017382:Reactive Oxygen Species / Q000378:metabolism; D024505:Tocopherols / Q000378:metabolism / Q000494:pharmacology; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology
D000975:Antioxidants; D005609:Free Radicals; D017382:Reactive Oxygen Species; C066323:tocopheroxy radical; D014810:Vitamin E; C002421:tocopherylquinone; D024505:Tocopherols