Antimicrobial activity of long-chain (E)-3-alken-2-ones.
(E)-3-tridecen-2-one, a compound identified from the interdigital glands of black-tailed deer (Odocoileus hemionus columbianus), has been shown to inhibit the growth of bacteria and fungi. Homologues of (E)-3-tridecen-2-one were prepared and screened for antimicrobial activity. For the fungus, Trichophyton mentagrophytes, the minimum inhibitory concentration (MIC) of (E)-3-Tetradecen-2-one was 12.5 microg/mL, and for the bacteria, Propionibacterium acnes, the MIC of (E)-3-heptadecen-2-one was 3.13 microg/mL.
Wood
William F
WF
Department of Chemistry, Humboldt State University, Arcata, CA 95521, USA. wfw2@humboldt.edu
Kubo
Aya
A
Shaffer
Tony B
TB
D000475:Alkenes / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011425:Propionibacterium acnes / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects
C093289:3-tridecen-2-one; D000475:Alkenes; D000890:Anti-Infective Agents