title: Detection of HIV-1 at between 20 and 49 copies per milliliter by the Cobas TaqMan HIV-1 v2.0 assay is associated with higher pretherapy viral load and less time on antiretroviral therapy.
abstract: New commercial techniques for determination of the viral load (VL) in plasma are able to detect as few as 20 copies of HIV-1 RNA/ml. The relevance of this new technical threshold is uncertain. Upon multivariate analysis, factors associated with detection of VLs between 20 and 49 copies/ml by the Cobas TaqMan HIV-1 v2.0 assay in an HIV clinic were the basal VL and time on antiretroviral therapy.
authors.affiliation: Microbiology Department, Hospital Universitario 12 de Octubre, Avenida de Córdoba sn., 28041 Madrid, Spain.
authors.forename: José F
authors.initials: JF
authors.lastname: Pascual-Pareja
authors.forename: Lorena
authors.initials: L
authors.lastname: Martínez-Prats
authors.forename: Joanna
authors.initials: J
authors.lastname: Luczkowiak
authors.forename: Silvana
authors.initials: S
authors.lastname: Fiorante
authors.forename: Rafael
authors.initials: R
authors.lastname: Rubio
authors.forename: Federico
authors.initials: F
authors.lastname: Pulido
authors.forename: Joaquín R
authors.initials: JR
authors.lastname: Otero
authors.forename: Rafael
authors.initials: R
authors.lastname: Delgado
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D025202:Molecular Diagnostic Techniques / Q000379:methods*; D010949:Plasma / Q000821:virology; D012367:RNA, Viral / Q000097:blood; D011933:Reagent Kits, Diagnostic; D013997:Time Factors; D019562:Viral Load
chemical_list: D012367:RNA, Viral; D011933:Reagent Kits, Diagnostic