Perilipin gene 1237 T > C polymorphism is not associated with obesity risk in northern Chinese Han adults.
OBJECTIVE
To identify the association between PLIN 1237 polymorphism and obesity in Chinese Han adults.


METHODS
A total of 994 adults (157 obese subjects, 322 overweight subjects, and 515 normal controls) were recruited from two rural communities. PLIN 1237 polymorphism was genotyped by polymerase chain reaction-restriction-fragment-length-polymorphism (PCR-RFLP). Association between PLIN polymorphisms and obesity status was estimated by ordinal logistic regression.


RESULTS
The three genotypes of PLIN 1237 were detected with a percentage of 54.3%, 37.1%, and 8.6% in TT, TC, and CC genotypes, respectively. For the PLIN 1237 polymorphism locus, the frequency of alleles T and C was 0.73 and 0.27, respectively. The PLIN 1237 polymorphisms were in Hardy-Weinberg equilibrium. PLIN 1237 polymorphism was not associated with obesity. The odds ratio for overweight or obesity for the CC+TC genotype was 0.8 (0.4, 1.4) in women (P = 0.4) and 0.6 (0.3, 1.3) in men (P = 0.2) after adjustment for age, education, household income and alcohol consumption, smoking, and physical activity.


CONCLUSIONS
Chinese Han adults have a lower frequency of variant-allele C in PLIN 1237. PLIN 1237 T > C polymorphism is not significantly associated with obesity in northern Chinese adults.
Hu
Dong-Sheng
DS
Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China. dongsheng_hu@hotmail.com
Xie
Jing
J
Yu
Da-Hai
DH
Xu
Guo-Heng
GH
Lu
Jie
J
Yang
Jin-Xiu
JX
Li
Chun-Yang
CY
Li
Yan-Yan
YY
D000328:Adult; D044466:Asian People / Q000235:genetics*; D002352:Carrier Proteins; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009765:Obesity / Q000235:genetics*; D000070778:Perilipin-1; D010750:Phosphoproteins / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D002352:Carrier Proteins; D000070778:Perilipin-1; D010750:Phosphoproteins