The antidiuretic hormone as an inhibitor of gastric secretion.
Male Heidenhain pouch dogs were used to evaluate the antidiuretic hormone as a physiological inhibitor of gastric acid secretion. The dogs were stimulated to a constant gastric secretion by food and 40-minute ADH infusions of different concentrations took place. The inhibition was expressed as a percentage and plotted against the dose of ADH. The physiological significance of these doses is discussed and evaluated against already published data on normal concentrations. In our experiments we found that 30 muU/kg min markedly influenced the gastric secretion, which means that this inhibition may well occur under physiological conditions.
Karlmark
B
B
Department of Physiology and Medical Biophysics, University of Uppsala, Uppsala, Sweden.
Obrink
K J
KJ
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism*; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D008297:Male; D023421:Models, Animal; D013270:Stomach / Q000187:drug effects* / Q000502:physiology; D014667:Vasopressins / Q000494:pharmacology*
D005765:Gastrointestinal Agents; D014667:Vasopressins