Recombinant human bone morphogenetic protein 2-induced heterotopic ossification of the retroperitoneum, psoas muscle, pelvis and abdominal wall following lumbar spinal fusion.
A 45-year-old man presented with vertebral collapse at L5 as an initial manifestation of multiple myeloma and underwent spinal fusion surgery using recombinant human bone morphogenetic protein-2 (rhBMP-2). Subsequent computed tomography (CT) scans and X-rays revealed heterotopic ossification of the left psoas muscle, pelvis, and anterior abdominal wall. While the occurrence of heterotopic ossification has previously been reported when rhBMP-2 has been used for spinal fusion surgery, this case demonstrates that it can occur to a much greater degree than previously seen.
Shah
Raj K
RK
The George Washington University School of Medicine, 2300 Eye Street NW, Washington, DC 20037, USA. rajshah@gwmail.gwu.edu
Moncayo
Valeria M
VM
Smitson
Robert D
RD
Pierre-Jerome
Claude
C
Terk
Michael R
MR
D034861:Abdominal Wall; D055396:Bone Morphogenetic Protein 2 / Q000009:adverse effects* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D009999:Ossification, Heterotopic / Q000139:chemically induced* / Q000000981:diagnostic imaging; D010388:Pelvis / Q000000981:diagnostic imaging*; D011860:Radiography, Abdominal; D011994:Recombinant Proteins / Q000009:adverse effects*; D013123:Spinal Fusion / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D011994:Recombinant Proteins