title: [A case of lung adenocarcinoma exhibiting Garcin syndrome].
abstract: We report a rare case of lung adenocarcinoma exhibiting Garcin syndrome due to skull base metastasis. A diagnosis of lung adenocarcinoma and intraperitoneal lymph node metastases was given to a 50-year-old man after pathological examination of a superclavicular lymph node biopsy. After systemic chemotherapy with cisplatin plus docetaxel, he had left hearing loss and vertigo. Since auditory nerve damage might occur due to cisplatin, the chemotherapy regimen was changed. However, facial paralysis occurred and his auditory nerve disorder progressed to deafness. He was diagnosed with Garcin syndrome due to the skull base and spinal cord metastases by brain and spine MRI, and cytological examination of the spinal fluid. After intrathecal administration of methotrexate and cranial irradiation, the progression of facial paralysis and auditory nerve disorder were halted. It is important to consider Garcin syndrome as a possible complication in lung cancer patients who have central nervous system symptoms.
authors.affiliation: Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine.
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Aida
authors.forename: Akira
authors.initials: A
authors.lastname: Igarashi
authors.forename: Sumito
authors.initials: S
authors.lastname: Inoue
authors.forename: Shuichi
authors.initials: S
authors.lastname: Abe
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shibata
authors.forename: Isao
authors.initials: I
authors.lastname: Kubota
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000473:pathology; D003389:Cranial Nerve Diseases / Q000209:etiology*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019292:Skull Base Neoplasms / Q000556:secondary; D013120:Spinal Cord Neoplasms / Q000556:secondary