title: [Effect of Chai-ling-tang (Sairei-to) for methotrexate concentration degradation delay by methotrexate high-dose therapy].
abstract: When methotrexate (MTX) salvage chemotherapy is performed for primary brain malignant lymphoma, use of leucovonrin rescue must often be extended due to delays in the degradation of blood concentration. We examined whether delay in MTX blood concentration degradation could be prevented by chai-ling-tang (Sairei-to) which has diuretic action. In the five cases examined were MTX blood concentration 72 hours after MTX administration was more than 1 x 10(-7) M. A single dose of 3 g of chai-ling-tang was administered three times on the day the MTX salvage chemotherapy was subsequently performed. MTX blood concentration at 72 hours post MTX administration and subsequent chai-ling-tang administration was less than 1 x 10(-7) M in all five cases. In addition, urea nitrogen and creatinine levels in serum increased and creatinine clearance decreased following MTX administration, however these changes induced by MTX administration were reduced by chai-ling-tang administration. Chai-ling-tang was effective in preventing an MTX deferent delay in MTX high-dose therapy by improving renal blood flow.
authors.affiliation: Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara-city, Kanagawa 228-8555, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Utsuki
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Oka
authors.forename: Sachio
authors.initials: S
authors.lastname: Suzuki
authors.forename: Sumito
authors.initials: S
authors.lastname: Sato
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Osawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Koizumi
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Miyajima
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fujii
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000097:blood* / Q000493:pharmacokinetics; D001806:Blood Urea Nitrogen; D001932:Brain Neoplasms / Q000188:drug therapy*; D003404:Creatinine / Q000097:blood; D004232:Diuretics / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage* / Q000097:blood* / Q000493:pharmacokinetics; D008875:Middle Aged; D016879:Salvage Therapy
chemical_list: D000964:Antimetabolites, Antineoplastic; D004232:Diuretics; D004365:Drugs, Chinese Herbal; C080903:sairei-to; D003404:Creatinine; D008727:Methotrexate