title: [Pathogenesis of posterior capsule opacification in pseudophakia].
abstract: The lens epithelial cells of A and E type are involved in pathogenesis of posterior capsule opacification (PCO). They undergo metaplasia into microfibroblasts, then migrate towards posterior capsule where they proliferate and form opacification. These processes are stimulated by cytokines and interleukines. The extracellular matrix which constitutes a scaffold for migration and attachment of epithelial cells plays an important role in PCO formation. Integrines intercede in this process.
authors.affiliation: Z Kliniki Chorób Oczu Collegium Medicum w Bydgoszczy Uniwersytetu Mikołaja Kopernika w Toruniu.
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Łukaszewska-Smyk
authors.forename: Józef
authors.initials: J
authors.lastname: Kałuzny
mesh_terms: D000818:Animals; D001036:Aphakia, Postcataract / Q000473:pathology*; D002387:Cataract Extraction / Q000009:adverse effects; D002465:Cell Movement; D004847:Epithelial Cells / Q000378:metabolism; D004868:Equipment Failure; D005109:Extracellular Matrix / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D007903:Lens Capsule, Crystalline / Q000378:metabolism* / Q000473:pathology*; D008679:Metaplasia; D011183:Postoperative Complications / Q000473:pathology; D019591:Pseudophakia / Q000473:pathology*
chemical_list: D016023:Integrins