title: The genetics of human adaptation: hard sweeps, soft sweeps, and polygenic adaptation.
abstract: There has long been interest in understanding the genetic basis of human adaptation. To what extent are phenotypic differences among human populations driven by natural selection? With the recent arrival of large genome-wide data sets on human variation, there is now unprecedented opportunity for progress on this type of question. Several lines of evidence argue for an important role of positive selection in shaping human variation and differences among populations. These include studies of comparative morphology and physiology, as well as population genetic studies of candidate loci and genome-wide data. However, the data also suggest that it is unusual for strong selection to drive new mutations rapidly to fixation in particular populations (the 'hard sweep' model). We argue, instead, for alternatives to the hard sweep model: in particular, polygenic adaptation could allow rapid adaptation while not producing classical signatures of selective sweeps. We close by discussing some of the likely opportunities for progress in the field.
authors.affiliation: Department of Human Genetics, The University of Chicago, Room 507, 929 E. 58th St, Chicago, IL 60637, USA. pritch@uchicago.edu
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Pritchard
authors.forename: Joseph K
authors.initials: JK
authors.lastname: Pickrell
authors.forename: Graham
authors.initials: G
authors.lastname: Coop
mesh_terms: D000220:Adaptation, Biological / Q000235:genetics*; D005828:Genetics, Population; D006801:Humans; D020412:Multifactorial Inheritance / Q000235:genetics*; D012641:Selection, Genetic