For T cell receptors, some breakups might not last forever.
Does the affinity or half-life of peptide-MHC-T cell receptor (TCR) interactions determine T cell activation? In this issue of Immunity, Aleksic et al. (2010) propose a role for the on rate through multiple rebindings to the same TCR.
Govern
Christopher C
CC
Department of Chemical Engineering, Massachusetts Institute of Technology, 770 Massachusetts Avenue, Cambridge, MA 02139, USA.
Chakraborty
Arup K
AK
D003602:Cytotoxicity, Immunologic; D006680:HLA Antigens / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008213:Lymphocyte Activation; D018448:Models, Immunological; D010446:Peptide Fragments / Q000276:immunology / Q000378:metabolism; D011485:Protein Binding; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction / Q000276:immunology; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D013997:Time Factors
D006680:HLA Antigens; D010446:Peptide Fragments; D011948:Receptors, Antigen, T-Cell