title: Recalcitrant fungal tunnel infection treated with intrastromal injection of voriconazole.
abstract: We are reporting a case of recalcitrant fungal tunnel infection treated with intrastromal injection of voriconazole. A 50-year-old woman underwent an uneventful phacoemulsification through a temporal corneal tunnel incision for age-related cataract in her right eye. One month post-surgery, she developed tunnel infection. Microbiological investigations revealed Aspergillus flavus as the offending pathogen. Despite intensive medical treatment, the corneal and anterior chamber infiltrate progressively enlarged. At the end of three and a half weeks, 0.1 ml of 0.05% voriconazole was injected intra-stromally surrounding the central end of the corneal infiltrate. On the subsequent follow-ups, a gradual improvement was noted and slowly it resolved completely. Topical therapy along with a judicious use of intrastromal administration of antifungal drugs may be of immense benefit in such cases prior to embarking on the surgical treatment.
authors.affiliation: Department of Cornea and External Diseases, Aditya Jyot Eye Hospital Pvt Ltd, Major Parmeshwaran Road, Wadala, Mumbai, 400031, India. docvandanajain@rediffmail.com
authors.forename: Vandana
authors.initials: V
authors.lastname: Jain
authors.forename: Nishikant
authors.initials: N
authors.lastname: Borse
authors.forename: Debraj
authors.initials: D
authors.lastname: Shome
authors.forename: Sundaram
authors.initials: S
authors.lastname: Natarajan
mesh_terms: D000287:Administration, Topical; D000935:Antifungal Agents / Q000008:administration & dosage*; D001228:Aspergillosis / Q000188:drug therapy / Q000209:etiology*; D001231:Aspergillus flavus; D002387:Cataract Extraction / Q000009:adverse effects / Q000379:methods*; D003319:Corneal Stroma; D015821:Eye Infections, Fungal / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D056965:Injections, Intraocular; D008875:Middle Aged; D018918:Phacoemulsification / Q000009:adverse effects*; D011743:Pyrimidines / Q000008:administration & dosage*; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole