Dipeptidyl peptidase IV and incident diabetes: the Atherosclerosis Risk in Communities (ARIC) study.
OBJECTIVE
Dipeptidyl peptidase IV (DPP-IV) is not only important in beta-cell function but also has proinflammatory actions. We aimed to investigate whether it could act as a link between low-grade chronic inflammation and diabetes.


METHODS
Using a case-cohort design, we followed 546 middle-aged individuals who developed diabetes and 538 who did not over approximately 9 years within the Atherosclerosis Risk in Communities study.


RESULTS
In weighted analyses, the correlation between DPP-IV levels and anthropometric, inflammatory, or metabolic variables was minimal (Spearman correlations <0.11). Those who developed diabetes had mean DPP-IV values similar to those who did not (P = 0.18). Individuals in the highest quartile of DPP-IV were not at greater risk of diabetes (hazard ratio 0.88 [95% CI 0.62-1.24]) in Cox proportional hazards models adjusting for age, sex, race, study center, and multiple additional diabetes risk factors.


CONCLUSIONS
Fasting DPP-IV levels do not appear to predict incident diabetes.
Luft
Vivian C
VC
Graduate Studies Program in Epidemiology, School of Medicine, Federal University of Rio Grandedo Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Schmidt
Maria Inês
MI
Pankow
James S
JS
Hoogeveen
Ron C
RC
Couper
David
D
Heiss
Gerardo
G
Duncan
Bruce B
BB
D050197:Atherosclerosis / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D018819:Dipeptidyl Peptidase 4 / Q000097:blood* / Q000276:immunology; D005215:Fasting; D005260:Female; D006801:Humans; D015994:Incidence; D007249:Inflammation / Q000097:blood / Q000453:epidemiology* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012307:Risk Factors; D012907:Smoking / Q000453:epidemiology
C042807:DPP4 protein, human; D018819:Dipeptidyl Peptidase 4