title: Generation and reaction of cyano-substituted aryllithium compounds using microreactors.
abstract: We developed a microflow method for the generation and reactions of aryllithiums bearing a cyano group, including o-lithiobenzonitrile, m-lithiobenzonitrile and p-lithiobenzonitrile. The method was effective at much higher temperatures than are required for conventional macrobatch reactions, by virtue of rapid mixing, short residence time, and efficient temperature control. In addition, reactions of o-lithiobenzonitrile with carbonyl compounds followed by trapping of the resulting lithium alkoxides with electrophiles were achieved in an integrated microflow system.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto 615-8510, Japan.
authors.forename: Aiichiro
authors.initials: A
authors.lastname: Nagaki
authors.forename: Heejin
authors.initials: H
authors.lastname: Kim
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Usutani
authors.forename: Chika
authors.initials: C
authors.lastname: Matsuo
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Yoshida
mesh_terms: D003486:Cyanides / Q000138:chemical synthesis / Q000737:chemistry*; D004867:Equipment Design; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis / Q000737:chemistry*; D018020:Lithium Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D044085:Microfluidics / Q000295:instrumentation* / Q000379:methods
chemical_list: D003486:Cyanides; D006841:Hydrocarbons, Aromatic; D018020:Lithium Compounds