title: Sepsis and its etiology among hospitalized children less than 1 year of age with intestinal failure on parenteral nutrition.
abstract: Infections accompany intestinal failure (IF) more commonly in children than in adults, with reported incidences of 2% to 29%. Appropriate care of the central venous catheter is the most important factor preventing infections; but in addition, bacteria translocate from the dysmotile gut as a possible source of septicemia. The aim of this retrospective analysis was to investigate the rate and the epidemiologic profile of septicemia in the patient group at greatest risk, namely, children less than 1 year of age with IF on parenteral nutrition (PN). Among 63 children less than 1 year of age who were included over a 2-year period, 55% were boys. The overall median age at the start of PN was 0.3 years, with a mean duration of 80 days. Some 68% of patients had at least one episode of septicemia, experiencing a mean of 1.5 episodes (range, 1-12). Also, 19% of children displayed polymicrobial bloodstream infections. The most common Gram-positive pathogens were Staphylococcus spp and Enterococcus spp; the Gram-negative pathogens were Klebsiella spp followed by Enterobacter spp and E. coli. Infants less than 1 year of age with IF >28 days experienced a high (68%) rate of sepsis. There was no difference in the incidence of catheter-related blood stream infection according to the primary underlying diagnosis. The most common pathogens were Staphylococcus spp and Enterococcus spp, similar to etiologies of sepsis among children in intensive care units.
authors.affiliation: Great Ormond Street Hospital for Children NHS Trust, London, UK.
authors.forename: J
authors.initials: J
authors.lastname: Pichler
authors.forename: V
authors.initials: V
authors.lastname: Horn
authors.forename: S
authors.initials: S
authors.lastname: Macdonald
authors.forename: S
authors.initials: S
authors.lastname: Hill
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002673:Child, Hospitalized; D016983:Enterococcus; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000453:epidemiology; D006801:Humans; D007223:Infant; D007239:Infections / Q000453:epidemiology; D007297:Inpatients; D007410:Intestinal Diseases / Q000628:therapy*; D007902:Length of Stay; D008297:Male; D010288:Parenteral Nutrition / Q000009:adverse effects*; D012189:Retrospective Studies; D018805:Sepsis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology; D013203:Staphylococcal Infections / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents