title: Administration of intravenous albumin around the time of oocyte retrieval reduces pregnancy rate without preventing ovarian hyperstimulation syndrome: a systematic review and meta-analysis.
abstract: OBJECTIVE
  The aim of this meta-analysis was to evaluate whether IV albumin infusion around the time of oocyte retrieval prevents ovarian hyperstimulation syndrome (OHSS) and affects the pregnancy rate.
  
  
  METHODS
  A meta-analysis of data from 9 randomized controlled trials including 1,613 women at high risk for developing OHSS in in vitro fertilization cycles was performed.
  
  
  RESULTS
  The combined incidence of severe OHSS was 6.0% in the IV albumin group and 7.9% in saline or no treatment groups. These rates were statistically not different (RR = 0.80, 95% CI = 0.57-1.12). Treatment with IV albumin significantly lowered the pregnancy rates (RR = 0.85, 95% CI = 0.74-0.98).
  
  
  CONCLUSIONS
  The combined data presented in this meta-analysis do not support a benefit for IV albumin around the time of oocyte retrieval in preventing OHSS and even showed a deleterious effect on the pregnancy rate.
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Bundang Seongnam, Gyeonggi, Korea.
authors.forename: Byung Chul
authors.initials: BC
authors.lastname: Jee
authors.forename: Chang Suk
authors.initials: CS
authors.lastname: Suh
authors.forename: Yong Beom
authors.initials: YB
authors.lastname: Kim
authors.forename: Seok Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Young Min
authors.initials: YM
authors.lastname: Choi
authors.forename: Jung Gu
authors.initials: JG
authors.lastname: Kim
authors.forename: Shin Yong
authors.initials: SY
authors.lastname: Moon
mesh_terms: D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D054315:Oocyte Retrieval / Q000379:methods*; D016471:Ovarian Hyperstimulation Syndrome / Q000188:drug therapy* / Q000517:prevention & control*; D011247:Pregnancy; D018873:Pregnancy Rate; D012709:Serum Albumin / Q000008:administration & dosage*; D017211:Treatment Failure
chemical_list: D012709:Serum Albumin