Palladium-catalyzed direct benzylation of azoles with benzyl carbonates.
The direct aromatic sp(2) C-H benzylation of azole compounds with benzyl carbonates proceeds efficiently in the presence of a Pd(2)(dba)(3)/dppp catalyst system and NaOAc as a base to afford the corresponding diarylmethanes in good yields. In addition, the same palladium catalyst enables the direct benzylic sp(3) C-H benzylation with the second benzyl carbonates without employing any external base.
Mukai
Tomoya
T
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Hirano
Koji
K
Satoh
Tetsuya
T
Miura
Masahiro
M
D001393:Azoles / Q000737:chemistry*; D002254:Carbonates / Q000737:chemistry*; D002384:Catalysis; D008697:Methane / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D001393:Azoles; D002254:Carbonates; D009942:Organometallic Compounds; D010165:Palladium; D008697:Methane