title: Microbe-dendritic cell dialog controls regulatory T-cell fate.
abstract: Each microenvironment is controlled by a specific set of regulatory elements that have to be finely and constantly tuned to maintain local homeostasis. These environments could be site specific, such as the gut environment, or induced by chronic exposure to microbes. Various populations of dendritic cells are central to the orchestration of this control. In this review, we discuss some new findings associating dendritic cells from defined compartments with the induction and control of regulatory T cells in the context of exposure to both commensal and pathogenic microbes.
authors.affiliation: Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20894, USA.
authors.forename: John R
authors.initials: JR
authors.lastname: Grainger
authors.forename: Jason A
authors.initials: JA
authors.lastname: Hall
authors.forename: Nicolas
authors.initials: N
authors.lastname: Bouladoux
authors.forename: Guillaume
authors.initials: G
authors.lastname: Oldenhove
authors.forename: Yasmine
authors.initials: Y
authors.lastname: Belkaid
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D019070:Cell Lineage / Q000276:immunology; D003141:Communicable Diseases / Q000276:immunology / Q000382:microbiology / Q000469:parasitology; D003713:Dendritic Cells / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology; D051858:Forkhead Transcription Factors / Q000276:immunology; D006706:Homeostasis; D006790:Host-Parasite Interactions; D054884:Host-Pathogen Interactions; D006801:Humans; D007410:Intestinal Diseases / Q000276:immunology / Q000382:microbiology / Q000469:parasitology; D007422:Intestines / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology; D010271:Parasites / Q000276:immunology*; D010581:Peyer's Patches / Q000276:immunology / Q000382:microbiology / Q000469:parasitology; D015398:Signal Transduction; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology
chemical_list: C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors