title: Parent initiated prednisolone for acute asthma in children of school age: randomised controlled crossover trial.
abstract: OBJECTIVE
  To evaluate the efficacy of a short course of parent initiated oral prednisolone for acute asthma in children of school age.
  
  
  METHODS
  Double blind, randomised, placebo controlled, crossover trial in which episodes of asthma, rather than participants, were randomised to treatment.
  
  
  METHODS
  The Barwon region of Victoria, Australia.
  
  
  METHODS
  Children aged 5-12 years with a history of recurrent episodes of acute asthma.
  
  
  METHODS
  A short course of parent initiated treatment with prednisolone (1 mg/kg a day) or placebo.
  
  
  METHODS
  The primary outcome measure was the mean daytime symptom score over seven days. Secondary outcome measures were mean night time symptom score over seven days, use of health resources, and school absenteeism.
  
  
  RESULTS
  230 children were enrolled in the study. Over a three year period, 131 (57%) of the participants contributed a total of 308 episodes of asthma that required parent initiated treatment: 155 episodes were treated with parent initiated prednisolone and 153 with placebo. The mean daytime symptom score was 15% lower in episodes treated with prednisolone than in those treated with placebo (geometric mean ratio 0.85, 95% CI 0.74 to 0.98; P=0.023). Treatment with prednisolone was also associated with a 16% reduction in the night time symptom score (geometric mean ratio 0.84, 95% CI 0.70 to 1.00; P=0.050), a reduced risk of health resource use (odds ratio 0.54, 95% CI 0.34 to 0.86; P=0.010), and reduced school absenteeism (mean difference -0.4 days, 95% CI -0.8 to 0.0 days; P=0.045).
  
  
  CONCLUSIONS
  A short course of oral prednisolone initiated by parents when their child experiences an episode of acute asthma may reduce asthma symptoms, health resource use, and school absenteeism. However, the modest benefits of this strategy must be balanced against potential side effects of repeated short courses of an oral corticosteroid.
  
  
  BACKGROUND
  ISRCTN 26232583.
authors.affiliation: Geelong Hospital, Barwon Health, Geelong 3220, Australia. peterv@barwonhealth.org.au
authors.forename: P J
authors.initials: PJ
authors.lastname: Vuillermin
authors.forename: C F
authors.initials: CF
authors.lastname: Robertson
authors.forename: J B
authors.initials: JB
authors.lastname: Carlin
authors.forename: S L
authors.initials: SL
authors.lastname: Brennan
authors.forename: M I
authors.initials: MI
authors.lastname: Biscan
authors.forename: M
authors.initials: M
authors.lastname: South
mesh_terms: D000208:Acute Disease; D000284:Administration, Oral; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010290:Parents; D011239:Prednisolone / Q000008:administration & dosage*; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D018927:Anti-Asthmatic Agents; D011239:Prednisolone