Cell type-dependent, infection-induced, aberrant DNA methylation in gastric cancer.
Epigenetic changes correspond to heritable modifications of the chromatin structure, which do not involve any alteration of the DNA sequence but nonetheless affect gene expression. These mechanisms play an important role in cell differentiation, but aberrant occurrences are also associated with a number of diseases, including cancer and neural development disorders. In particular, aberrant DNA methylation induced by H. Pylori has been found to be a significant risk factor in gastric cancer. To investigate the sensitivity of different genes and cell types to this infection, a computational model of methylation in gastric crypts is developed. In this article, we review existing results from physical experiments and outline their limitations, before presenting the computational model and investigating the influence of its parameters.
Perrin
Dimitri
D
Centre for Scientific Computing & Complex Systems Modelling, Dublin City University, Ireland. dperrin@computing.dcu.ie
Ruskin
Heather J
HJ
Niwa
Tohru
T
D003198:Computer Simulation; D019175:DNA Methylation; D005753:Gastric Mucosa / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000502:physiology; D054884:Host-Pathogen Interactions; D008957:Models, Genetic; D014411:Neoplastic Stem Cells / Q000378:metabolism / Q000382:microbiology; D013274:Stomach Neoplasms / Q000150:complications / Q000235:genetics* / Q000473:pathology