[Obesity and liver disease].
Obesity is associated with a higher risk of developing non-alcoholic fatty liver disease (NAFLD) and contributes to the progression of liver diseases of distinct etiologies such as chronic hepatitis C virus (HCV) infection. The discovery that adipose tissue is submitted to a state of chronic inflammation able to secrete adipokines has allowed a connection to be established between the metabolic alterations that lead to triglyceride accumulation and liver inflammation, reinforcing the role of hepatocellular lipotoxicity in the pathogenesis of NAFLD. In addition, although HCV genotype 3 induces steatosis, it is currently believed that obesity and its associated alterations, such as insulin resistance, are involved in progression of HCV-mediated liver disease, as well as that of other chronic liver diseases of diverse etiologies.
Miquilena Colina
María Eugenia
ME
Unidad de Investigación, Hospital Universitario Santa Cristina, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Madrid, España.
García Monzón
Carmelo
C
D000263:Adenylate Kinase / Q000502:physiology; D054392:Adipokines / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D018450:Disease Progression; D005227:Fatty Acids / Q000378:metabolism; D005234:Fatty Liver / Q000209:etiology / Q000503:physiopathology; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D007249:Inflammation; D007333:Insulin Resistance; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008107:Liver Diseases / Q000209:etiology* / Q000503:physiopathology; D000071518:Liver X Receptors; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009765:Obesity / Q000145:classification / Q000150:complications* / Q000453:epidemiology / Q000503:physiopathology; D057093:Orphan Nuclear Receptors / Q000502:physiology; D047493:PPAR alpha / Q000502:physiology; D014280:Triglycerides / Q000378:metabolism
D054392:Adipokines; D005227:Fatty Acids; D000071518:Liver X Receptors; D057093:Orphan Nuclear Receptors; D047493:PPAR alpha; D014280:Triglycerides; D000263:Adenylate Kinase