Mydriasis induced by sub-Tenon's ropivacaine injection in patients undergoing strabismus surgery.
OBJECTIVE
To investigate the effects of sub-Tenon's capsule ropivacaine injection on pupillary diameter in strabismus surgery.


METHODS
A total of 16 patients were randomly assigned to 2 groups. The ropivacaine group (R) received sub-Tenon's ropivacaine 1% (2.5-3 mL) injections. In the control group (C), general anesthesia was induced and a saline solution (2.5-3 mL) was injected in the sub-Tenon's capsule. Pupillary diameter was measured at baseline and 2 and 5 minutes from the injections. The effects of the injections were expressed as a ratio of final (5 minutes) versus basal diameter.


RESULTS
A significant mydriasis occurred in the ropivacaine group when compared with the control group (Group R vs Group C ratio = 2.32, p < 0.0001) or with unoperated fellow eye (R vs unoperated eye ratio = 2.29, p < 0.0001).


CONCLUSIONS
Ropivacaine in the sub-Tenon's capsule induces a mydriasis probably related to a pharmacological ciliary ganglion block.
Savino
Gustavo
G
Institute of Ophthalmology, Catholic University, Rome, Italy.
Perrotta
Vittoria
V
Colucci
Daniela
D
Balia
Laura
L
Sammartino
Maria
M
Garra
Rossella
R
Petroni
Sergio
S
Mastrocola
Alessandra
A
Balestrazzi
Emilio
E
D000328:Adult; D000577:Amides / Q000008:administration & dosage / Q000009:adverse effects*; D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects*; D003238:Connective Tissue / Q000187:drug effects; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D015878:Mydriasis / Q000139:chemically induced*; D009801:Oculomotor Muscles / Q000601:surgery; D013508:Ophthalmologic Surgical Procedures; D011680:Pupil / Q000187:drug effects*; D000077212:Ropivacaine; D013285:Strabismus / Q000601:surgery*; D055815:Young Adult
D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine