title: Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease.
abstract: Simple bioactive sphingolipids include ceramide, sphingosine and their phosphorylated forms sphingosine 1-phosphate and ceramide 1-phosphate. These molecules are crucial regulators of cell functions. In particular, they play important roles in the regulation of angiogenesis, apoptosis, cell proliferation, differentiation, migration, and inflammation. Decoding the mechanisms by which these cellular functions are regulated requires detailed understanding of the signaling pathways that are implicated in these processes. Most importantly, the development of inhibitors of the enzymes involved in their metabolism may be crucial for establishing new therapeutic strategies for treatment of disease.
authors.affiliation: Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Bilbao, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Gangoiti
authors.forename: Luz
authors.initials: L
authors.lastname: Camacho
authors.forename: Lide
authors.initials: L
authors.lastname: Arana
authors.forename: Alberto
authors.initials: A
authors.lastname: Ouro
authors.forename: Maria H
authors.initials: MH
authors.lastname: Granado
authors.forename: Leyre
authors.initials: L
authors.lastname: Brizuela
authors.forename: Josefina
authors.initials: J
authors.lastname: Casas
authors.forename: Gemma
authors.initials: G
authors.lastname: Fabriás
authors.forename: José Luis
authors.initials: JL
authors.lastname: Abad
authors.forename: Antonio
authors.initials: A
authors.lastname: Delgado
authors.forename: Antonio
authors.initials: A
authors.lastname: Gómez-Muñoz
mesh_terms: D000818:Animals; D055572:Ceramidases / Q000037:antagonists & inhibitors / Q000378:metabolism; D002518:Ceramides / Q000737:chemistry / Q000378:metabolism; D004194:Disease; D006801:Humans; D007249:Inflammation; D007527:Isoenzymes / Q000378:metabolism; D008246:Lysophospholipids / Q000737:chemistry / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D015394:Molecular Structure; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013107:Sphingolipids / Q000737:chemistry / Q000378:metabolism*; D013110:Sphingosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D000099157:Sphingosine Kinase
chemical_list: D055572:Ceramidases; D002518:Ceramides; D007527:Isoenzymes; D008246:Lysophospholipids; D017853:Phosphotransferases (Alcohol Group Acceptor); D013107:Sphingolipids; D013110:Sphingosine; D000099157:Sphingosine Kinase; C065576:ceramide 1-phosphate; C060506:sphingosine 1-phosphate