Aquaporins in tumor growth and angiogenesis.
The aquaporins (AQPs) are a family of transmembrane water channel proteins widely distributed and play a major role in transcellular and transepithelial water movement. Moreover, recent evidence indicates that AQPs may be involved in cell migration and angiogenesis. This review article summarizes literature data concerning the involvement of AQPs in tumor growth, angiogenesis and metastatic process and suggest a potential therapeutic approach by antagonizing their biological activity.
Nico
Beatrice
B
Department of Human Anatomy and Histology, University of Bari Medical School, Bari, Italy.
Ribatti
Domenico
D
D000818:Animals; D020346:Aquaporins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D048708:Cell Growth Processes / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism
D020346:Aquaporins