title: Pro-oxidant action of pyrroloquinoline quinone: characterization of protein oxidative modifications.
abstract: Pyrroloquinoline quinone (PQQ), a putative essential nutrient, is a redox modulator in cell and animal models. Here we characterized PQQ-induced protein oxidative modifications in a model peptide and protein, and we propose that the mechanism of protein modification by PQQ is redox cycling-mediated oxidation. PQQ may contribute to the regulation of intracellular protein functions through its prooxidant action.
authors.affiliation: Department of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan. ishii_t@u-shizuoka-ken.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ishii
authors.forename: Mitsugu
authors.initials: M
authors.lastname: Akagawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Naito
authors.forename: Osamu
authors.initials: O
authors.lastname: Handa
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Takagi
authors.forename: Taiki
authors.initials: T
authors.lastname: Mori
authors.forename: Shigenori
authors.initials: S
authors.lastname: Kumazawa
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakayama
mesh_terms: D000975:Antioxidants / Q000737:chemistry; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D045542:PQQ Cofactor / Q000737:chemistry*; D050050:Protein Carbonylation; D011506:Proteins / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D011506:Proteins; D017382:Reactive Oxygen Species; D045542:PQQ Cofactor