title: [Clinical observation on treatment of functional constipation with compound plantain-senna granules].
abstract: OBJECTIVE
  To investigate the efficacy and safety of compound plantain-senna granule (CPSG) in the treatment of functional constipation.
  
  
  METHODS
  Eighty patients with confirmed diagnosis of functional constipation were assigned to 2 groups. The 40 patients in the treatment group were treated with CPSG 5 g per day, while the 40 patients in the control group were treated with equal volume of starch granule, for 2 weeks totally. The defecating frequency and stool property, the scores of fecal discharge difficulty and accompanied symptoms, the gastrointestinal transmission time, and adverse reaction of treatment in the two groups were observed before and after treatment.
  
  
  RESULTS
  Parameters of defecating frequency, stool property, the scores of fecal discharge difficulty, accompanied symptoms and the gastrointestinal transmission time were unchanged after treatment in the control group (P > 0.05); while in the treatment group, they improved significantly (P < 0.05) and showed significant difference to those in the control group respectively (P < 0. 05). No serious adverse reaction occurred in both groups.
  
  
  CONCLUSIONS
  CPSG can obviously increase the defecating frequency, change the stool property, alleviate the fecal discharging difficult symptom and accompanied symptom, and shorten the gastrointestinal transmission time in patients with functional constipation with good security and tolerability.
authors.affiliation: Department of Digestive Medicine, the First Affiliated Hospital of Xinxiang Medical College, Henan Weihui. nn21882001@yahoo.com.cn
authors.forename: Chao-xian
authors.initials: CX
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002400:Cathartics / Q000627:therapeutic use*; D002908:Chronic Disease; D003248:Constipation / Q000188:drug therapy*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D010943:Plantago / Q000737:chemistry; D012676:Senna Extract / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002400:Cathartics; D004338:Drug Combinations; D012676:Senna Extract