title: Prediction of myocardial infarction using coronary risk scores among Japanese male workers: 3M Study.
abstract: BACKGROUND
  It remains unclear how much coronary risk factors contribute to the prediction of myocardial infarction among Japanese populations.
  
  
  RESULTS
  A nested case-control study of Japanese male workers aged 35 to 65 years was conducted between 1997 and 2000 in the Morbidity of Myocardial Infarction Multicenter Study in Japan (3M Study). Two hundred four myocardial infarctions were identified and two controls per case were selected by matching for age. We calculated odds ratios using a conditional logistic regression model, and constructed risk predictive models for the risk of myocardial infarction using coronary risk factors. The multivariable odds ratios (95 percent confidence intervals) of myocardial infarction were 2.02 (1.29-3.16) for high blood pressure, 2.33 (1.51-3.59) for high LDL-cholesterol, 4.16 (2.36-7.33) for low HDL-cholesterol, 1.49 (0.94-2.35) for high triglycerides, 1.46 (0.89-2.39) for high glucose, and 2.95 (1.90-4.59) for current smoking. A large reduction of the predictive value for myocardial infarction was shown after exclusion of high LDL-cholesterol (reduction of predictive value was -3.4%), further exclusion of low HDL-cholesterol (-7.1%), and further exclusion of current smoking (-16.4%).
  
  
  CONCLUSIONS
  High LDL-cholesterol and low HDL-cholesterol as well as current smoking had high predictive values for myocardial infarction among Japanese middle-aged male workers.
authors.affiliation: Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Noda
authors.forename: Koutatsu
authors.initials: K
authors.lastname: Maruyama
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
authors.forename: Seitaro
authors.initials: S
authors.lastname: Dohi
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Terai
authors.forename: Shigenori
authors.initials: S
authors.lastname: Fujioka
authors.forename: Koichi
authors.initials: K
authors.lastname: Goto
authors.forename: Seichi
authors.initials: S
authors.lastname: Horie
authors.forename: Shuji
authors.initials: S
authors.lastname: Nakano
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Hirobe
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology*; D012307:Risk Factors