title: Evaluating the Brighton Collaboration case definitions, aseptic meningitis, encephalitis, myelitis, and acute disseminated encephalomyelitis, by systematic analysis of 255 clinical cases.
abstract: OBJECTIVE
  Brighton Collaboration (BC) case definitions are independent from presumed causes or triggers, hence should be applicable in routine clinical settings.
  
  
  METHODS
  255 cases with discharge diagnoses of aseptic meningitis (ASM; n=164), encephalitis (ENC; n=48), myelitis (MYE; n=8), ADEM (n=10), or bacterial meningitis (BM; n=59; control group) were tested against the BC case definitions ASM, ENC, MYE, and ADEM. Overall rates of agreement between BC criteria and discharge diagnoses were 70%, 78%, 97%, and 97% for ASM, ENC, MYE and ADEM, respectively.
  
  
  CONCLUSIONS
  BC case definitions are easily applicable in retrospective chart reviews allowing causality assessments with minimal selection bias.
authors.affiliation: Charité University Medicine, Department of Pediatrics, 13553 Berlin, Germany. Barbara.Rath@gmail.com
authors.forename: Barbara
authors.initials: B
authors.lastname: Rath
authors.forename: Manya
authors.initials: M
authors.lastname: Magnus
authors.forename: Ulrich
authors.initials: U
authors.lastname: Heininger
mesh_terms: D000465:Algorithms; D004660:Encephalitis / Q000175:diagnosis*; D004673:Encephalomyelitis, Acute Disseminated / Q000175:diagnosis*; D006801:Humans; D008582:Meningitis, Aseptic / Q000175:diagnosis*; D016920:Meningitis, Bacterial / Q000175:diagnosis*; D009187:Myelitis / Q000175:diagnosis*; D012680:Sensitivity and Specificity