title: Synthesis of nanobioglass and formation of apatite rods to occlude exposed dentine tubules and eliminate hypersensitivity.
abstract: The occlusion of patent dentine tubules may reduce or eliminate hypersensitivity by restricting dentinal fluid movement. The efficacy of a novel sol-gel nanobioglass and a melt-derived bioglass to occlude tubules and promote apatite formation was tested by mechanically brushing a slurry of bioglass powder and human saliva onto dentine possessing exposed tubules. Scanning electron microscopy, focused ion beam and energy-dispersive X-ray spectroscopy were used to characterize the powders and assess tubule occlusion. Melt-derived bioglass possessed an irregular particle morphology and had a mean size of 3.30 +/- 0.42 microm. The sol-gel bioglass particles were spherical, with a mean size of 0.65 +/- 0.19 microm. Dentine treated with melt-derived bioglass exhibited a tightly adherent continuous apatite layer. Treatment with nanobioglass resulted in particle deposition within tubules and formation of apatite rods which were tightly adherent to tubule walls and continuous to a measured depth of 270 microm.
authors.affiliation: Biomaterials Engineering Group (BioMEG), Department of Oral and Dental Science, Bristol University, Bristol BS12LY, UK. a.curtis@bristol.ac.uk
authors.forename: A R
authors.initials: AR
authors.lastname: Curtis
authors.forename: N X
authors.initials: NX
authors.lastname: West
authors.forename: B
authors.initials: B
authors.lastname: Su
mesh_terms: D001031:Apatites / Q000737:chemistry*; D002516:Ceramics / Q000138:chemical synthesis* / Q000627:therapeutic use*; D003766:Dental Occlusion; D003804:Dentin / Q000378:metabolism* / Q000648:ultrastructure; D003807:Dentin Sensitivity / Q000628:therapy*; D006801:Humans; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011208:Powders
chemical_list: D001031:Apatites; C022107:Bioglass; D011208:Powders