[Association between genetic polymorphism of UGT1A7 and susceptibility of bladder cancer].
OBJECTIVE
To investigate the association between genetic polymorphism of UGT1A7 and susceptibility of bladder cancer.


METHODS
Based upon a case-control study, UGT1A7 polymorphisms were determined by the semi-nested polymerase chain reaction (SN-PCR) and allele-specific polymerase chain reaction (AS-PCR) in 208 cases with bladder cancer and 205 non-tumor controls. Risks were evaluated by unconditional logistic regression analysis.


RESULTS
The frequency of variant homozygous genotype in cases (20.7%) was higher than that in controls (12.2%) and the difference was statistically significant [P < 0.05, OR = 2.16 (1.18 - 3.96)]. The frequency of variant allele (*)3 in cases was higher than that in controls (27.9%, 20.5% respectively) and the difference was statistically significant [P = 0.009, OR = 1.56 (95%CI: 1.12 - 2.18)]. The smokers with variant homozygous and heterozygous genotypes showed an increased risk of bladder cancer compared with those with wild genotype [2.16 (95%CI: 1.07 - 4.36), 2.64 (95%CI: 1.02 - 6.80) respectively]. There was no association between the UGT1A7 polymorphisms and the pathological grade and clinical stage of bladder cancer (both P > 0.05).


CONCLUSIONS
The genetic polymorphisms of UGT1A7 are associated with the susceptibility of bladder cancer and have interactions with smoking in bladder carcinogenesis.
Liu
Jian
J
Department of Urinary Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Yang
Xiao-ming
XM
Liu
Gang
G
Chang
Lian-sheng
LS
Zhang
Li-rong
LR
Song
Dong-kui
DK
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D016022:Case-Control Studies; D004260:DNA Repair; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D014453:Glucuronosyltransferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012907:Smoking; D001749:Urinary Bladder Neoplasms / Q000453:epidemiology / Q000235:genetics*; D055815:Young Adult
D014453:Glucuronosyltransferase; C107611:UDP-glucuronosyltransferase, UGT1A7