title: Thyroid papillary carcinoma in a 3-year-old American boy with a family history of thyroid cancer: a case report and literature review.
abstract: Differentiated thyroid carcinoma is a rare malignancy in children. It represents 0.4% to 3.0% of all childhood malignancies, with greater than 70% of cases presenting between the ages of 11 to 17 years and is exceptionally rare in children under 5 years of age. The most common type of differentiated thyroid carcinoma in children is papillary thyroid carcinoma, most of which are believed to be related to radiation exposure and only approximately 5% of cases have a family history of papillary thyroid cancer. In this report, we present a papillary thyroid carcinoma in a 3-year-old American boy with a family history of thyroid cancer and no known history of radiation exposure. A literature review with discussion on the management and treatment of pediatric papillary thyroid carcinoma follows.
authors.affiliation: Department of Surgery, Newark Beth Israel Medical Center, Saint Barnabas Health Care System, Newark, NJ 07112, USA.
authors.forename: Lovedeep
authors.initials: L
authors.lastname: Khara
authors.forename: Adam
authors.initials: A
authors.lastname: Silverman
authors.forename: Colin
authors.initials: C
authors.lastname: Bethel
authors.forename: Cyril
authors.initials: C
authors.lastname: D'Cruz
authors.forename: Xinlai
authors.initials: X
authors.lastname: Sun
mesh_terms: D002291:Carcinoma, Papillary / Q000473:pathology* / Q000601:surgery; D002648:Child; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000473:pathology* / Q000601:surgery; D013965:Thyroidectomy