title: Thermal model for optimization of vascular laser tissue soldering.
abstract: Laser tissue soldering (LTS) is a promising technique for tissue fusion based on a heat-denaturation process of proteins. Thermal damage of the fused tissue during the laser procedure has always been an important and challenging problem. Particularly in LTS of arterial blood vessels strong heating of the endothelium should be avoided to minimize the risk of thrombosis. A precise knowledge of the temperature distribution within the vessel wall during laser irradiation is inevitable. The authors developed a finite element model (FEM) to simulate the temperature distribution within blood vessels during LTS. Temperature measurements were used to verify and calibrate the model. Different parameters such as laser power, solder absorption coefficient, thickness of the solder layer, cooling of the vessel and continuous vs. pulsed energy deposition were tested to elucidate their impact on the temperature distribution within the soldering joint in order to reduce the amount of further animal experiments. A pulsed irradiation with high laser power and high absorbing solder yields the best results.
authors.affiliation: Institute of Applied Physics, Department of Biomedical Photonics, University of Bern, Bern, Switzerland.
authors.forename: Serge
authors.initials: S
authors.lastname: Bogni
authors.forename: Oliver
authors.initials: O
authors.lastname: Stumpp
authors.forename: Michael
authors.initials: M
authors.lastname: Reinert
authors.forename: Martin
authors.initials: M
authors.lastname: Frenz
mesh_terms: D000042:Absorption; D000465:Algorithms; D000818:Animals; D001011:Aorta / Q000502:physiology; D001808:Blood Vessels / Q000502:physiology*; D002138:Calibration; D003198:Computer Simulation; D020342:Finite Element Analysis; D066298:In Vitro Techniques; D053685:Laser Therapy / Q000379:methods*; D008954:Models, Biological; D011817:Rabbits; D013696:Temperature; D013997:Time Factors; D014867:Water
chemical_list: D014867:Water