title: African Americans exhibit a predominant allele in the midst of extensive KIR2DL1 allelic diversity.
abstract: KIR2DL1 alleles were identified by DNA sequencing of the coding region from amplified genomic DNA from 100 random African Americans. The majority of individuals (97%) carried a KIR2DL1 locus. Allele KIR2DL1*00302 was found in 68% of individuals but KIR2DL1*00401, *002, *00303, *006, and *007 were also frequent. Eleven new alleles were described: KIR2DL1*00403, *01101, *01102, *012, *013N, *014, *015, *016, *017, *018, and *019. Nine of the novel alleles encoded amino acid substitutions located throughout the receptor; one allele carried a stop codon in the exon encoding the first extracellular domain.
authors.affiliation: Departments of Pediatrics and Oncology, CW Bill Young Marrow Donor Recruitment and Research Program, Georgetown University Medical Center, Washington, D.C. 20057, USA.
authors.forename: L
authors.initials: L
authors.lastname: Hou
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: B
authors.initials: B
authors.lastname: Jiang
authors.forename: J
authors.initials: J
authors.lastname: Ng
authors.forename: C K
authors.initials: CK
authors.lastname: Hurley
mesh_terms: D001741:Black or African American / Q000235:genetics*; D000483:Alleles; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D054342:Receptors, KIR2DL1 / Q000235:genetics* / Q000276:immunology
chemical_list: C093100:KIR2DL1 protein, human; D054342:Receptors, KIR2DL1