title: [Meta-analysis on the association of G894T polymorphism in endothelial nitric oxide synthase gene and essential hypertension in Chinese population].
abstract: OBJECTIVE
  To evaluate the relationship between G894T (Glu298Asp) polymorphism in the endothelial nitric oxide synthase (eNOS) gene and essential hypertension in Chinese population from different regions.
  
  
  METHODS
  Odds ratios (ORs) of G894T genotype and allele distributions in essential hypertension patients against healthy controls were analyzed. All the relevant studies were screened with poor-qualified studies eliminated. Meta-analysis software MIX (Meta-analysis with interactive explanations-version 1.71), was applied for investigating and analyzing heterogeneity among individual studies and summarizing the effects across studies, and the risk of publication bias was evaluated.
  
  
  RESULTS
  A total of 1900 cases and 1216 controls from 10 studies were included. The heterogeneity between studies was significant (P = 0.013; P = 0.011) and there were substantial sources of publication bias (P = 0.049; P = 0.038). The pooled OR (with 95%CI) of GT + TT vs. GG genotype was 1.79 (1.33 - 2.42) (Z = 3.83, P < 0.001), and the pooled OR (with 95%CI) of T vs. G allele was 1.73 (1.32 - 2.27) (Z = 3.92, P < 0.001).
  
  
  CONCLUSIONS
  In Chinese population, mainly the Hans ethnic group, 894G-->T mutation in the eNOS appeared to be related to essential hypertension.
authors.affiliation: Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin 150081, China.
authors.forename: Cong-Ju
authors.initials: CJ
authors.lastname: Wang
authors.forename: Jing-Bo
authors.initials: JB
authors.lastname: Zhao
authors.forename: Jia-Liang
authors.initials: JL
authors.lastname: Xu
authors.forename: Ze-Lin
authors.initials: ZL
authors.lastname: Xiang
authors.forename: Chang-Wei
authors.initials: CW
authors.lastname: Liang
authors.forename: Jie
authors.initials: J
authors.lastname: Li
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005787:Gene Frequency; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000208:ethnology / Q000235:genetics*; D009154:Mutation; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D017594:Publication Bias
chemical_list: D052250:Nitric Oxide Synthase Type III