title: Trends in antimicrobial resistance of Acinetobacter baumannii isolates from a metropolitan Detroit health system.
abstract: A phenotypic and genotypic analysis of Acinetobacter baumannii was conducted from 2003 to 2008 in Detroit, MI. The incidence of A. baumannii increased from 1.7 to 3.7/1,000 patient days during the study period. Susceptibility to ampicillin-sulbactam and imipenem decreased from approximately 90% to approximately 40%. Genotyping revealed polyclonality, suggesting either emergence of multiple resistant strains or spread of a common genetic element. The sharp rise mandates major multidisciplinary interventions to optimize management of this multidrug-resistant pathogen.
authors.affiliation: Division of Infectious Diseases, Detroit Medical Center, Wayne State University, Detroit, Michigan 48201, USA.
authors.forename: Tara
authors.initials: T
authors.lastname: Reddy
authors.forename: Teena
authors.initials: T
authors.lastname: Chopra
authors.forename: Dror
authors.initials: D
authors.lastname: Marchaim
authors.forename: Jason M
authors.initials: JM
authors.lastname: Pogue
authors.forename: George
authors.initials: G
authors.lastname: Alangaden
authors.forename: Hossein
authors.initials: H
authors.lastname: Salimnia
authors.forename: Dina
authors.initials: D
authors.lastname: Boikov
authors.forename: Shiri
authors.initials: S
authors.lastname: Navon-Venezia
authors.forename: Robert
authors.initials: R
authors.lastname: Akins
authors.forename: Philip
authors.initials: P
authors.lastname: Selman
authors.forename: Sorabh
authors.initials: S
authors.lastname: Dhar
authors.forename: Keith S
authors.initials: KS
authors.lastname: Kaye
mesh_terms: D000046:Academic Medical Centers / Q000706:statistics & numerical data; D000151:Acinetobacter Infections / Q000188:drug therapy* / Q000453:epidemiology* / Q000382:microbiology; D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000235:genetics; D000667:Ampicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use; D008824:Michigan / Q000453:epidemiology; D010802:Phylogeny; D015995:Prevalence; D012189:Retrospective Studies; D013407:Sulbactam / Q000627:therapeutic use; D014505:Urban Population / Q000706:statistics & numerical data
chemical_list: D000900:Anti-Bacterial Agents; C035444:sultamicillin; D015378:Imipenem; D000667:Ampicillin; D013407:Sulbactam