Chitosan/sodium tripolyphosphate nanoparticles: preparation, characterization and application as drug carrier.
With the existence of amino groups, chitosan (CS) possesses positive charge, so it can self-assemble with tripolyphotspate (TPP) possessing negative charge via ionic gelation. We here synthesized CS/TPP nanoparticles, and then characterized it with the infrared spectra (IR) and scanning electron microscope (SEM) and transmission electron microscopy (TEM) and used bovine serum albumin (BSA) as a model drug to investigate sustained-release properties of CS/TPP nanoparticles. Infrared spectrum of CS/TPP nanoparticles indicated that CS was cross-linked with TPP. A homogeneous size distribution and good dispersion and micro-porous surface of CS/TPP nanoparticles were observed. The highest encapsulation efficiency (EE) of the BSA in CS/TPP nanoparticles prepared in different concentration of CS reached 79.74%, while BSA continually and smoothly released up to one week.
Yang
Wenjing
W
State Key Laboratory of Bioelectronics, Southeast University, Nanjing 210096, China.
Fu
Jing
J
Wang
Ting
T
He
Nongyue
N
D048271:Chitosan / Q000737:chemistry*; D003460:Crystallization / Q000379:methods*; D004058:Diffusion; D004339:Drug Compounding / Q000379:methods; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D053769:Nanocapsules / Q000737:chemistry*; D050997:Nanomedicine / Q000379:methods*; D010316:Particle Size; D011122:Polyphosphates / Q000737:chemistry*; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013499:Surface Properties
D046911:Macromolecular Substances; D053769:Nanocapsules; D011122:Polyphosphates; D012710:Serum Albumin, Bovine; D048271:Chitosan; C005692:triphosphoric acid