title: Is the risk of allergic hypersensitivity to fungi increased by indoor exposure to moulds?
abstract: OBJECTIVE
  Moulds are frequently found in the indoor environment of residential houses. An association between domestic mould contamination and respiratory symptoms has been reported, but mould exposure as a risk factor for allergy to moulds is not well documented. The aim of the study was to evaluate the prevalence and associated factors of allergic hypersensitivity to moulds.
  
  
  METHODS
  A group of 243 participants was examined. Of these 118 lived in dwellings with evident signs of fungal contamination (study group) and 125 in non-contaminated sites (controls). An interview, skin prick tests to common and fungal allergens, evaluation of total serum IgE and specific IgE to moulds, resting spirometry as well as mycological analysis in building were performed for each participant.
  
  
  RESULTS
  19.8% subjects were sensitized to at least one mould allergen. Logistic regression analysis revealed that the history of respiratory and skin symptoms, smoking cigarettes in the past and positive skin prick tests (SPT) to common allergens (dust mite and grass pollens) or the presence of a cat as a pet animal were the significant associated factors of hypersensitivity to moulds.
  
  
  CONCLUSIONS
  The association between indoor fungal exposure and the development of fungal allergy was not confirmed in our study.
authors.affiliation: Department of Occupational Diseases and Toxicology, Nofer Institute of Occupational Medicine, Łódź, Poland. martaz@imp.lodz.pl
authors.forename: Marta
authors.initials: M
authors.lastname: Wiszniewska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Walusiak-Skorupa
authors.forename: Beata
authors.initials: B
authors.lastname: Gutarowska
authors.forename: Anna
authors.initials: A
authors.lastname: Krakowiak
authors.forename: Cezary
authors.initials: C
authors.lastname: Pałczyński
mesh_terms: D000328:Adult; D016902:Air Pollution, Indoor / Q000009:adverse effects*; D000818:Animals; D016022:Case-Control Studies; D005260:Female; D005658:Fungi / Q000276:immunology*; D006798:Housing; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology* / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood; D016015:Logistic Models; D008297:Male; D011044:Poland / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D012882:Skin Tests; D013147:Spirometry; D011795:Surveys and Questionnaires
chemical_list: D007073:Immunoglobulin E