title: Mydriasis induced by sub-Tenon's ropivacaine injection in patients undergoing strabismus surgery.
abstract: OBJECTIVE
  To investigate the effects of sub-Tenon's capsule ropivacaine injection on pupillary diameter in strabismus surgery.
  
  
  METHODS
  A total of 16 patients were randomly assigned to 2 groups. The ropivacaine group (R) received sub-Tenon's ropivacaine 1% (2.5-3 mL) injections. In the control group (C), general anesthesia was induced and a saline solution (2.5-3 mL) was injected in the sub-Tenon's capsule. Pupillary diameter was measured at baseline and 2 and 5 minutes from the injections. The effects of the injections were expressed as a ratio of final (5 minutes) versus basal diameter.
  
  
  RESULTS
  A significant mydriasis occurred in the ropivacaine group when compared with the control group (Group R vs Group C ratio = 2.32, p < 0.0001) or with unoperated fellow eye (R vs unoperated eye ratio = 2.29, p < 0.0001).
  
  
  CONCLUSIONS
  Ropivacaine in the sub-Tenon's capsule induces a mydriasis probably related to a pharmacological ciliary ganglion block.
authors.affiliation: Institute of Ophthalmology, Catholic University, Rome, Italy.
authors.forename: Gustavo
authors.initials: G
authors.lastname: Savino
authors.forename: Vittoria
authors.initials: V
authors.lastname: Perrotta
authors.forename: Daniela
authors.initials: D
authors.lastname: Colucci
authors.forename: Laura
authors.initials: L
authors.lastname: Balia
authors.forename: Maria
authors.initials: M
authors.lastname: Sammartino
authors.forename: Rossella
authors.initials: R
authors.lastname: Garra
authors.forename: Sergio
authors.initials: S
authors.lastname: Petroni
authors.forename: Alessandra
authors.initials: A
authors.lastname: Mastrocola
authors.forename: Emilio
authors.initials: E
authors.lastname: Balestrazzi
mesh_terms: D000328:Adult; D000577:Amides / Q000008:administration & dosage / Q000009:adverse effects*; D000772:Anesthesia, Local; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects*; D003238:Connective Tissue / Q000187:drug effects; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D015878:Mydriasis / Q000139:chemically induced*; D009801:Oculomotor Muscles / Q000601:surgery; D013508:Ophthalmologic Surgical Procedures; D011680:Pupil / Q000187:drug effects*; D000077212:Ropivacaine; D013285:Strabismus / Q000601:surgery*; D055815:Young Adult
chemical_list: D000577:Amides; D000779:Anesthetics, Local; D000077212:Ropivacaine