title: Harnessing human dendritic cell subsets for medicine.
abstract: Immunity results from a complex interplay between the antigen-non-specific innate immune system and the antigen-specific adaptive immune system. The cells and molecules of the innate system employ non-clonal recognition receptors including lectins, Toll-like receptors, NOD-like receptors, and helicases. B and T lymphocytes of the adaptive immune system employ clonal receptors recognizing antigens or their derived peptides in a highly specific manner. An essential link between innate and adaptive immunity is provided by dendritic cells (DCs). DCs can induce such contrasting states as immunity and tolerance. The recent years have brought a wealth of information on the biology of DCs revealing the complexity of this cell system. Indeed, DC plasticity and subsets are prominent determinants of the type and quality of elicited immune responses. In this article, we summarize our recent studies aimed at a better understanding of the DC system to unravel the pathophysiology of human diseases and design novel human vaccines.
authors.affiliation: Baylor Institute for Immunology Research and INSERM U899, Dallas, TX 75204, USA.
authors.forename: Hideki
authors.initials: H
authors.lastname: Ueno
authors.forename: Nathalie
authors.initials: N
authors.lastname: Schmitt
authors.forename: Eynav
authors.initials: E
authors.lastname: Klechevsky
authors.forename: Alexander
authors.initials: A
authors.lastname: Pedroza-Gonzalez
authors.forename: Toshimichi
authors.initials: T
authors.lastname: Matsui
authors.forename: Gerard
authors.initials: G
authors.lastname: Zurawski
authors.forename: SangKon
authors.initials: S
authors.lastname: Oh
authors.forename: Joseph
authors.initials: J
authors.lastname: Fay
authors.forename: Virginia
authors.initials: V
authors.lastname: Pascual
authors.forename: Jacques
authors.initials: J
authors.lastname: Banchereau
authors.forename: Karolina
authors.initials: K
authors.lastname: Palucka
mesh_terms: D056704:Adaptive Immunity; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007167:Immunotherapy / Q000379:methods*; D008214:Lymphocytes / Q000276:immunology; D015398:Signal Transduction; D014612:Vaccines / Q000276:immunology*
chemical_list: D014612:Vaccines