Rapid dissemination of newly introduced Plasmodium vivax genotypes in South Korea.
Reemerged Plasmodium vivax malaria in South Korea has not yet been eradicated despite continuous governmental efforts. It has rather become an endemic disease. Our study aimed to determine the genetic diversity in P. vivax merozoite surface protein-1 (PvMSP-1) and circumsporozoite protein (PvCSP) genes over an extended period after its reemergence to its current status. Sequence analysis of PvMSP-1 gene sequences from the 632 P. vivax isolates during 1996-2007 indicates that most isolates recently obtained were different from isolates obtained in the initial reemergence period. There was initially only one subtype (recombinant) present but its subtypes have varied since 2000; six MSP-1 subtypes were recently found. A similar variation was observed by CSP gene analysis; a new CSP subtype was found. Understanding genetic variation patterns of the parasite may help to analyze trends and assess extent of endemic malaria in South Korea.
Choi
Yien-Kyoung
YK
Center for Immunology and Pathology, National Institute of Health, Korea Centers for Disease Control and Prevention, Seoul, Republic of Korea.
Choi
Kyung-Mi
KM
Park
Mi-Hyun
MH
Lee
Eun-Gyu
EG
Kim
Yeon-Joo
YJ
Lee
Byeong-Chul
BC
Cho
Shin-Hyung
SH
Rhie
Ho-Gun
HG
Lee
Ho-Sa
HS
Yu
Jae-Ran
JR
Lee
Joo-Shil
JS
Kim
Tong-Soo
TS
Kim
Jung-Yeon
JY
D000595:Amino Acid Sequence; D000818:Animals; D005838:Genotype; D006801:Humans; D015994:Incidence; D016780:Malaria, Vivax / Q000453:epidemiology* / Q000469:parasitology*; D020066:Merozoite Surface Protein 1 / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D010966:Plasmodium vivax / Q000235:genetics*; D015995:Prevalence; D015800:Protozoan Proteins / Q000235:genetics; D056910:Republic of Korea / Q000453:epidemiology; D013997:Time Factors
D020066:Merozoite Surface Protein 1; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan