Molecular and biological aspects of the bovine immunodeficiency virus.
The bovine immunodeficiency virus (BIV) was isolated in 1969 from a cow, R-29, with a wasting syndrome suggesting bovine leucosis. The virus, first designated bovine visna-like virus, remained unstudied until HIV was discovered in 1983. Then, it was demonstrated in 1987 that the bovine R-29 isolate was a lentivirus with striking similarity to the human immunodeficiency virus (HIV). Moreover, BIV has the most complex genomic structure among all identified lentiviruses shown by several regulatory/accessory genes encoding proteins, some of which are involved in the regulation of virus gene expression. This manuscript aims to review biological and molecular aspects of BIV, with emphasis on regulatory/accessory viral genes/proteins which are involved in virus expression.
Corredor
Andrea G
AG
Department of Biological Sciences, University of Québec at Montréal, P.O. Box 8888, Succursale Centre-Ville, Montréal, Québec, H3C 3P8, Canada.
St-Louis
Marie-Claude
MC
Archambault
Denis
D
D000818:Animals; D001483:Base Sequence; D002417:Cattle; D015696:Gene Products, tat / Q000235:genetics*; D016087:Immunodeficiency Virus, Bovine / Q000235:genetics* / Q000378:metabolism; D016180:Lentivirus Infections / Q000821:virology*; D008969:Molecular Sequence Data; D012191:Retroviridae Proteins / Q000235:genetics*; D020079:Terminal Repeat Sequences / Q000235:genetics
D015696:Gene Products, tat; D012191:Retroviridae Proteins