title: Pharmacokinetics of garenoxacin in elderly patients with respiratory tract infections.
abstract: The pharmacokinetics of the new oral des-fluoroquinolone antimicrobial garenoxacin (GRNX) was investigated in elderly patients with respiratory tract infections. Patients were treated with GRNX (200 mg or 400 mg) once daily for 7 days. Plasma GRNX concentrations were determined and pharmacokinetic parameters were estimated by Bayesian predictions using reported population pharmacokinetic parameters. At each dose, the maximum plasma concentration (C(max)) and the area under the concentration-time curve (AUC) were comparable with those reported in young subjects, except that the estimated C(max) and AUC values in one patient receiving the 200 mg dose whose body weight and creatinine clearance rate (CL(Cr)) were 38 kg and 17 mL/min, respectively, were higher than those of the other patients given 200 mg GRNX and were comparable with those of patients who received the 400mg dose. These results suggest that the recommended dose of GRNX should be 400 mg for most elderly and young patients, but only 200 mg in patients whose body weight and CL(Cr) are < 40 kg and < 30 mL/min, respectively.
authors.affiliation: Respiratory Center, Asahikawa Medical College, 2-1-1-1 Midorigaoka Higashi, Asahikawa, Hokkaido 078-8510, Japan. yohsaki@asahikawa-med.ac.jp
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Ohsaki
authors.forename: Kazutoyo
authors.initials: K
authors.lastname: Morita
authors.forename: Hiroki
authors.initials: H
authors.lastname: Takeda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kishino
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Okumura
authors.forename: Satoru
authors.initials: S
authors.lastname: Fujiuchi
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010949:Plasma / Q000737:chemistry; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; C419689:garenoxacin