Dynamic proteomics in modeling of the living cell. Protein-protein interactions.
This review is devoted to describing, summarizing, and analyzing of dynamic proteomics data obtained over the last few years and concerning the role of protein-protein interactions in modeling of the living cell. Principles of modern high-throughput experimental methods for investigation of protein-protein interactions are described. Systems biology approaches based on integrative view on cellular processes are used to analyze organization of protein interaction networks. It is proposed that finding of some proteins in different protein complexes can be explained by their multi-modular and polyfunctional properties; the different protein modules can be located in the nodes of protein interaction networks. Mathematical and computational approaches to modeling of the living cell with emphasis on molecular dynamics simulation are provided. The role of the network analysis in fundamental medicine is also briefly reviewed.
Terentiev
A A
AA
Russian State Medical University, ul. Ostrovityanova 1, Moscow, Russia. aaterent@mtu-net.ru
Moldogazieva
N T
NT
Shaitan
K V
KV
D000818:Animals; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods; D008962:Models, Theoretical; D056004:Molecular Dynamics Simulation; D046912:Multiprotein Complexes / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D025941:Protein Interaction Mapping / Q000379:methods*; D011506:Proteins / Q000737:chemistry / Q000378:metabolism; D040901:Proteomics / Q000379:methods*; D049490:Systems Biology / Q000379:methods; D020798:Two-Hybrid System Techniques
D046912:Multiprotein Complexes; D011506:Proteins