title: GH/IGF-I regulation in obesity--mechanisms and practical consequences in children and adults.
abstract: Growth hormone (GH) secretion in children and adults is profoundly, but reversibly, suppressed in obesity. Since GH deficiency leads to increased fat mass, differentiation of both conditions remains challenging. Here we review the known and still speculative mechanisms underlying the inhibitory effects of obesity on GH secretion including peripheral factors like IGF-I and insulin, as well as central hypothalamic/pituitary modulators. We further discuss the basis of current testing for GH deficiency in obesity and the validity of the various provocative tests in overweight subjects.
authors.affiliation: Department of Endocrinology, Christie Hospital, Manchester, UK.
authors.forename: Ilonka
authors.initials: I
authors.lastname: Kreitschmann-Andermahr
authors.forename: Pablo
authors.initials: P
authors.lastname: Suarez
authors.forename: Rachel
authors.initials: R
authors.lastname: Jennings
authors.forename: Nina
authors.initials: N
authors.lastname: Evers
authors.forename: Georg
authors.initials: G
authors.lastname: Brabant
mesh_terms: D000293:Adolescent; D000328:Adult; D001120:Arginine; D002648:Child; D005230:Fatty Acids, Nonesterified / Q000502:physiology; D005260:Female; D054439:Ghrelin / Q000502:physiology; D019382:Human Growth Hormone / Q000172:deficiency / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000502:physiology*; D008297:Male; D009765:Obesity / Q000175:diagnosis / Q000503:physiopathology*; D015203:Reproducibility of Results
chemical_list: D005230:Fatty Acids, Nonesterified; D054439:Ghrelin; D007328:Insulin; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I; D001120:Arginine