Adrenaline-induced lipolysis in isolated rat mesenteric adipocytes is higher in the large intestine than in the small intestine.
We determined adrenaline-induced lipolysis in mesenteric adipocytes separated from the small and large intestinal parts, because there are large differences in absorbed nutrients and substances between these two intestinal segments. The adrenaline sensitivity was much higher in the mesenteric adipocytes associated with the large intestine without any significant difference in lipolytic capacity. Intestinal bacteria or their metabolites possibly contributed to this phenomenon.
Shinoki
Aki
A
Laboratory of Nutritional Biochemistry, Division of Applied Bioscience, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan.
Hara
Hiroshi
H
D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D004837:Epinephrine / Q000378:metabolism* / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007408:Intestinal Absorption / Q000187:drug effects; D007420:Intestine, Large / Q000187:drug effects / Q000378:metabolism* / Q000382:microbiology; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism* / Q000382:microbiology; D008066:Lipolysis; D008297:Male; D008643:Mesentery / Q000187:drug effects / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; D004837:Epinephrine