[Relationship of tetramethylpyrazine on expression of vascular endothelial growth factor and development of adjuvant-induced arthritis in rats].
OBJECTIVE
To explore the effect of tetramethylpyrazine (TMP) on the expression of vascular endothelial growth factor (VEGF) in the synovium of adjuvant-induced arthritis (AIA) in rats.


METHODS
AIA rats were treated with different doses of TMP. The effects of treatment were monitored by footpad thickness, contents of tumor necrosis factor-alpha (TNF-alpha) in serum, microvessel density (MVD) and the expression of VEGF protein in the synovium.


RESULTS
Compared with arthritis model, 100 mg x kg(-1) TMP could remarkably reduce the footpad thickness, contents of TNF-alpha in serum and the expression of VEGF in the synovium.


CONCLUSIONS
TMP can attenuate the degree of chronic inflammation in AIA rats, and its mechanism might be associated with inhibiting the expression of VEGF.
Ma
Qiang
Q
College of Pharmaceutical Sciences, Southwest University, Chongqing 400715, China. maqiang860107@126.com
Chen
Gang
G
Zhang
Jifen
J
Feng
Binbin
B
Xu
Xiaoyu
X
D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D008297:Male; D011719:Pyrazines / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics* / Q000378:metabolism
D011719:Pyrazines; D042461:Vascular Endothelial Growth Factor A; C017953:tetramethylpyrazine