Digestion and absorption of Siraitia grosvenori triterpenoids in the rat.
When administered to rats, mogroside V (a pentaglucose-conjugated mogroside), the main sweetening component of Siraitia grosvenori, was mostly degraded by digestive enzymes and intestinal microflora, and was excreted in the feces as mogrol (aglycone) and its mono- and diglucosides. However, trace amounts of mogrol and its monoglucoside were found in the portal blood as sulfates and/or glucuronide conjugates.
Murata
Yuji
Y
Biochemical Laboratory, Saraya Company, Ltd., Kashiwara, Osaka, Japan.
Ogawa
Takahisa
T
Suzuki
Yasushi A
YA
Yoshikawa
Shinichi
S
Inui
Hiroshi
H
Sugiura
Masaki
M
Nakano
Yoshihisa
Y
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D004063:Digestion; D005638:Fruit / Q000737:chemistry*; D020719:Glucuronides / Q000378:metabolism; D007408:Intestinal Absorption; D029775:Momordica / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D013549:Sweetening Agents / Q000008:administration & dosage / Q000378:metabolism*; D014315:Triterpenes / Q000008:administration & dosage / Q000378:metabolism*
D001786:Blood Glucose; D020719:Glucuronides; D013549:Sweetening Agents; D014315:Triterpenes; C041740:mogroside V