[Incidence and risk factors on HIV infection among injection drug users in Dehong prefecture area of Yunnan province].
OBJECTIVE
To determine the incidence and risk factors on HIV infection among injection drug users (IDU) in Dehong prefecture area of Yunnan province.


METHODS
An epidemiological cohort of HIV-negative IDU had been developed and followed since October, 2004. HIV new infections and related behaviors had been investigated every six months.


RESULTS
By the end of 2008, 760 HIV-negative IDU had been recruited and followed for a total of 1153.6 person-years. 47 new HIV infections were identified, with an overall incidence of 4.07/100 person-years during the follow-up period. The HIV incidence was 4.45/100 person-years during 2004 - 2006, 4.50/100 person-years in 2007 and 2.54/100 person-years in 2008. Both the behavior of drug injection and the HIV incidence among the cohort had substantially decreased during the follow-up period. Multiple regression analysis using Cox proportional hazard model indicated that people with Jing-po ethnicity (Hazard ratio, HR = 2.56, 95%CI: 1.06 - 6.19) and other minorities except for Dai (HR = 3.26, 95%CI: 0.89 - 11.96) were at higher risk for HIV infection than the people with Han ethnicity. People injecting drugs with (HR = 2.27, 95%CI: 0.98 - 5.25) or without (HR = 5.27, 95%CI: 2.25 - 12.34) needle sharing were at higher risk for HIV infection than those reporting having no drug injection behavior during the follow-up period.


CONCLUSIONS
Both the behavior of drug injection and the HIV incidence among former IDU in Dehong prefecture area of Yunnan province had been decreasing during the four years. However, needle sharing remained the most important risk factor for HIV new infection among IDUs. IDUs with different ethnicities seemed to have different risks towards HIV infection.
Duan
Song
S
Dehong Prefecture Center for Disease Control and Prevention, Yunnan 678400, China.
Xiang
Li-fen
LF
Yang
Yue-cheng
YC
Ye
Run-hua
RH
Jia
Man-hong
MH
Luo
Hong-bing
HB
Fu
Li-ru
LR
Song
Li-jun
LJ
Zhao
Yu-xian
YX
Yang
Jian-hua
JH
Wang
Bin
B
Liu
Zhi-yuan
ZY
Pu
Yong-cheng
YC
Han
Wen-xiang
WX
Yang
Zhong-jie
ZJ
Li
Wei-mei
WM
Wang
Ji-bao
JB
Zhu
Wei-ming
WM
He
Na
N
D000328:Adult; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008913:Minority Groups; D016485:Needle Sharing; D012307:Risk Factors; D015819:Substance Abuse, Intravenous / Q000453:epidemiology*