title: Monoclonal antibodies used as prophylactic, therapeutic and diagnostic agents.
abstract: Monoclonal antibodies can be of mouse, part mouse part human (chimeric, humanized), or of human origin. Their preparation involves hybridoma, gene cloning, gene recombination, phage display, and gene transfection techniques. The preparation, mechanism of action, uses, and possible adverse effects of most of the available monoclonal antibodies used as prophylactic, therapeutic, and diagnostic agents are reviewed.
authors.affiliation: Department of Microbiology and Immunology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
authors.forename: Marita
authors.initials: M
authors.lastname: Chakhtoura
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Abdelnoor
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000096:biosynthesis / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D000922:Immunotoxins / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D000922:Immunotoxins