title: Molecular cytogenetic analysis of Korean patients with Waldenström macroglobulinemia.
abstract: To compare the molecular cytogenetic characteristics between Waldenström macroglobulinemia (WM) and multiple myeloma (MM), we performed interphase fluorescent in situ hybridization (FISH) in Korean patients with WM and MM. Forty patients with WM and 132 patients with MM were enrolled onto the study. FISH was performed with seven different probes: 6q21, 6q23, CEP4, CEP9, immunoglobulin (IgH) breakapart, RB1 gene, and 1q25. Out of 22 WM patients, 4 (18%) had abnormal karyotypes, mainly structural changes on conventional karyotyping. After performing FISH for the available 29 cases, deletions of 6q23 and 6q21 were newly detected in 3 cases (10%). There was no other anomaly, including trisomy 4 in WM. No 6q deletion was observed in MM patients, but RB1 deletion was the most common change (45%), followed by IgH translocation (42%) and gain of 1q (38%). In conclusion, Korean WM patients had a low rate of 6q deletion (10%) and no trisomy 4.
authors.affiliation: Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam-si, Gyeongi-do, 463-707, Korea.
authors.forename: Soo-Mee
authors.initials: SM
authors.lastname: Bang
authors.forename: Ji-Weon
authors.initials: JW
authors.lastname: Seo
authors.forename: Kyung Un
authors.initials: KU
authors.lastname: Park
authors.forename: Seok Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Kihyun
authors.initials: K
authors.lastname: Kim
authors.forename: Sun-Hee
authors.initials: SH
authors.lastname: Kim
authors.forename: Sung Ran
authors.initials: SR
authors.lastname: Cho
authors.forename: Hugh C
authors.initials: HC
authors.lastname: Kim
authors.forename: Jaewoo
authors.initials: J
authors.lastname: Song
authors.forename: Jin Seok
authors.initials: JS
authors.lastname: Kim
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Kim
authors.forename: Jae Hoon
authors.initials: JH
authors.lastname: Lee
authors.forename: Je-Jung
authors.initials: JJ
authors.lastname: Lee
authors.forename: Myung Geun
authors.initials: MG
authors.lastname: Shin
authors.forename: Cheolwon
authors.initials: C
authors.lastname: Suh
authors.forename: Hyun Sook
authors.initials: HS
authors.lastname: Chi
authors.forename: Do-Yeun
authors.initials: DY
authors.lastname: Oh
authors.forename: Jong-Ho
authors.initials: JH
authors.lastname: Won
authors.forename: Hyo Jung
authors.initials: HJ
authors.lastname: Kim
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Yoon
authors.forename: Dong Soon
authors.initials: DS
authors.lastname: Lee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001854:Bone Marrow Cells / Q000473:pathology; D002869:Chromosome Aberrations; D002896:Chromosomes, Human, Pair 6; D015331:Cohort Studies; D005260:Female; D017353:Gene Deletion; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D007621:Karyotyping; D007723:Korea; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics; D008258:Waldenstrom Macroglobulinemia / Q000235:genetics* / Q000473:pathology
chemical_list: D007143:Immunoglobulin Heavy Chains