title: [Associations of the genetic polymorphisms in CYP11B2 gene with nonfamilial structural atrial fibrillation].
abstract: OBJECTIVE
  To investigate whether polymorphisms in CYP11B2 gene are associated with nonfamilial structural atrial fibrillation (AF) in Chinese Han population.
  
  
  METHODS
  A fine-designed pair-matched hospital based case-control study was performed in 297 cases and 297 controls. We investigated two tagging single nucleotide polymorphisms (tSNPs)-rs4545, rs3802228 in CYP11B2 gene by using GenomeLab SNPstream technique.
  
  
  RESULTS
  Two tSNPs were consistent with Hardy-Weinberg expectations in case and control groups. Compared with controls, the left atrial diameter of cases was significantly higher (P < 0.0001). No significant difference in genotype or allele frequencies of tSNPs in CYP11B2 gene was observed. However, at the site of rs3802228 in 3'UTR of the case group, the left atrial diameter in AF patients with GG genotype was significantly higher than others. After adjusted for covariates age, smoking, Body mass index and hypertension, we did not observe the association of rs4545, rs3802228 with AF.
  
  
  CONCLUSIONS
  Our result suggested that polymorphisms of rs4545 in CYP11B2 gene might not be associated with atrial fibrillation but polymorphism of 3'UTR rs3802228 locus in CYP11B2 gene might be associated with atrial structural remodeling.
authors.affiliation: Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan 250012, China.
authors.forename: Fei-fei
authors.initials: FF
authors.lastname: Cao
authors.forename: Xing-dong
authors.initials: XD
authors.lastname: Chen
authors.forename: Qun-shan
authors.initials: QS
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Lu
authors.forename: Li
authors.initials: L
authors.lastname: Jin
mesh_terms: D044466:Asian People / Q000235:genetics*; D001281:Atrial Fibrillation / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006325:Heart Atria / Q000473:pathology; D006801:Humans; D020641:Polymorphism, Single Nucleotide
chemical_list: D019405:Cytochrome P-450 CYP11B2