title: Rare influenza A (H3N2) variants with reduced sensitivity to antiviral drugs.
abstract: In 2007 and 2008 in Myanmar, we detected influenza viruses A (H3N2) that exhibited reduced sensitivity to both zanamivir and amantadine. These rare and naturally occurring viruses harbored a novel Q136K mutation in neuraminidase and S31N mutation in M2.
authors.affiliation: Department of Public Health, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan. clyde@med.niigata-u.ac.jp
authors.forename: Clyde
authors.initials: C
authors.lastname: Dapat
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Reiko
authors.initials: R
authors.lastname: Saito
authors.forename: Yadanar
authors.initials: Y
authors.lastname: Kyaw
authors.forename: Yi Yi
authors.initials: YY
authors.lastname: Myint
authors.forename: Nay
authors.initials: N
authors.lastname: Lin
authors.forename: Htun Naing
authors.initials: HN
authors.lastname: Oo
authors.forename: Khin Yi
authors.initials: KY
authors.lastname: Oo
authors.forename: Ne
authors.initials: N
authors.lastname: Win
authors.forename: Makoto
authors.initials: M
authors.lastname: Naito
authors.forename: Go
authors.initials: G
authors.lastname: Hasegawa
authors.forename: Isolde C
authors.initials: IC
authors.lastname: Dapat
authors.forename: Hassan
authors.initials: H
authors.lastname: Zaraket
authors.forename: Tatiana
authors.initials: T
authors.lastname: Baranovich
authors.forename: Makoto
authors.initials: M
authors.lastname: Nishikawa
authors.forename: Takehiko
authors.initials: T
authors.lastname: Saito
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Suzuki
mesh_terms: D000547:Amantadine / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral / Q000235:genetics; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects* / Q000235:genetics; D007251:Influenza, Human / Q000821:virology; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D002052:Myanmar; D009439:Neuraminidase / Q000235:genetics; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D014763:Viral Matrix Proteins / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics; D053243:Zanamivir / Q000494:pharmacology*; D000086082:Viroporin Proteins
chemical_list: D000547:Amantadine; D000998:Antiviral Agents; D009439:Neuraminidase; D014763:Viral Matrix Proteins; D014764:Viral Proteins; D053243:Zanamivir; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins; C487630:NA protein, influenza A virus