Anemia in diabetic patients at an internal medicine ward: clinical correlates and prognostic significance.
BACKGROUND
Characteristics and prognostic significance of anemia in hospitalized diabetic patients are unknown.


METHODS
We studied 3145 unselected patients admitted to two Internal Medicine Departments, 872 (27.7%) of whom were diabetic. Forty diabetic patients died during the first hospitalization period. Out of the remaining 832 patients, 334 (40.2%) were anemic and evaluated for survival. In 87 diabetic patients, the cause of anemia was evident on admission, whereas the other 247 had to be further investigated for etiology of anemia.


RESULTS
Compared to non-anemic diabetic patients, the diabetic anemic patients were older (mean age 71.4 vs. 64.4 years, P<.001) and predominantly females (52.4% vs. 44.4%, P<.02). Of the 247 evaluated patients, 38% were deficient in iron, 12% in vitamin B(12) and/or folate, 54% had anemia of chronic disease, 47% suffered from heart failure, 39% had renal dysfunction and 22% were complex nursing care patients and/or had diabetic foot. On median follow-up of 19.2 months, mortality rate was higher in anemic compared to non-anemic diabetic patients (17.3% vs. 4%, P<.001), the main cause of death being infection. Male sex (P=.03), albuminuria (P=.01) and heart failure (P=.06) were associated with shorter survival, male sex being the most significant (OR 2.02, 95% CI 1.04-4.00).


CONCLUSIONS
Frequency of anemia was increased in diabetic patients admitted to the Internal Medicine Departments, compared to the studies performed on ambulatory patient populations. Anemia was multifactorial and associated with higher mortality, predominantly from infections. Males with albuminuria and heart failure were at higher risk of death.
Almoznino-Sarafian
Dorit
D
Department of Internal Medicine F, Assaf Harofeh Medical Center (affiliated to Sackler School of Medicine, Tel-Aviv University), 70300 Zerifin, Israel.
Shteinshnaider
Miriam
M
Tzur
Irma
I
Bar-Chaim
Adina
A
Iskhakov
Elena
E
Berman
Sylvia
S
Efrati
Shai
S
Modai
David
D
Cohen
Natan
N
Gorelik
Oleg
O
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000740:Anemia / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D016009:Chi-Square Distribution; D048909:Diabetes Complications / Q000175:diagnosis / Q000401:mortality; D005260:Female; D006760:Hospitalization; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009748:Nutrition Disorders / Q000150:complications / Q000175:diagnosis; D011379:Prognosis; D016016:Proportional Hazards Models; D018709:Statistics, Nonparametric