Changes in purines concentration in the cerebrospinal fluid of patients experiencing pain: a case-control study.
This study analyzes the relationship between extracellular purines and pain perception in humans. Cerebrospinal fluid (CSF) levels of purines and their metabolites were compared between patients displaying acute and/or chronic pain syndromes and control subjects. The CSF levels of IMP, inosine, guanosine and uric acid were significantly increased in the chronic pain group and correlated with pain severity (P<0.05). Patients displaying both chronic and acute pain presented similar changes in the CSF purines concentration (P<0.05). However, in the acute pain group, only CSF inosine and uric acid levels were significantly increased (P<0.05). These findings suggest that purines, in special inosine, guanosine and uric acid, are associated with the spinal mechanisms underlying nociception.
Schmidt
André P
AP
Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Böhmer
Ana Elisa
AE
Soares
Félix A
FA
Posso
Irimar P
IP
Machado
Sheila B
SB
Mendes
Florentino F
FF
Portela
Luis Valmor C
LV
Souza
Diogo O
DO
D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001938:Brazil; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000134:cerebrospinal fluid* / Q000523:psychology*; D010147:Pain Measurement / Q000379:methods; D017288:Pain Threshold / Q000502:physiology*; D011446:Prospective Studies; D011687:Purines / Q000134:cerebrospinal fluid*; D013223:Statistics as Topic; D055815:Young Adult
D011687:Purines; C030985:purine