title: Impact of chronic fluorosis on left ventricular diastolic and global functions.
abstract: Sixty three patients with endemic fluorosis (36 males/27 females; mean age 33.9+/-8.6years) and 45 age, sex and body mass index (BMI) matched healthy controls (30 males/15 females; mean age 32.7+/-8.8years) were included in this study. Basic echocardiographic measurements, left ventricular diastolic parameters and left ventricular myocardial performance index (MPI) were measured. The left ventricular MPI was calculated as (isovolumic contraction time+isovolumic relaxation time)/aortic ejection time by Doppler. The urine fluoride levels of fluorosis patients were significantly higher than control subjects as expected (1.9+/-0.1mg/l vs 0.4+/-0.1mg/l respectively; P<0.001). Isovolumic relaxation time (IVRT) and deceleration time (DT) were significantly higher in fluorosis patients than in controls (for IVRT 106.9+/-15.6ms vs 96.7+/-12.2ms; P<0.001 and for DT 211.7+/-30.7ms vs 188.0+/-30.0ms; P<0.001, respectively). MPI was significantly higher in fluorosis patients than in controls (0.62+/-0.15ms vs 0.49+/-0.10ms; P<0.001, respectively). We have shown that chronic fluorosis patients had left ventricular diastolic and global dysfunctions.
authors.affiliation: Department of Cardiology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey. drercanvarol@yahoo.com
authors.forename: Ercan
authors.initials: E
authors.lastname: Varol
authors.forename: Selahattin
authors.initials: S
authors.lastname: Akcay
authors.forename: I Hakki
authors.initials: IH
authors.lastname: Ersoy
authors.forename: Banu Kale
authors.initials: BK
authors.lastname: Koroglu
authors.forename: Simge
authors.initials: S
authors.lastname: Varol
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003971:Diastole; D015150:Echocardiography, Doppler; D005260:Female; D005459:Fluorides / Q000009:adverse effects*; D009050:Fluorosis, Dental / Q000503:physiopathology*; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006439:Hemodynamics; D006801:Humans; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced* / Q000503:physiopathology; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D005459:Fluorides