[Aneugenic effect of ionizing radiation in mammalian and human somatic cells].
Aneuploidy is among the most serious impairments of hereditary material in somatic and germline cells of living organisms. Chromosome loss or the appearance of an extra homolog in the chromosome set can result in either cell death or the development of various neoplasms with high probability of malignancy. It was traditionally believed that ionizing radiation produces primarily a clastogenic effect. However, there is apparently an aneugenic component of radiation, with mechanism different from that of structural chromosome damage. The present review focuses on the evidence for the existence of the aneugenic effect of ionizing radiation in mammalian and human somatic cells.
Vasil'ev
S A
SA
Timoshevskiĭ
V A
VA
Lebedev
I N
IN
D000782:Aneuploidy; D000818:Animals; D016923:Cell Death / Q000528:radiation effects; D019457:Chromosome Breakage / Q000528:radiation effects*; D002877:Chromosomes, Human / Q000235:genetics / Q000378:metabolism*; D005854:Germ Cells / Q000378:metabolism*; D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000235:genetics / Q000378:metabolism*; D011839:Radiation, Ionizing