[Pharmacokinetics of fangchinoline and tetrandrine in rats].
OBJECTIVE
To investigate the pharmacokinetics profile of fangchinoline and tetrandrine in rats after administration of single compound and mixture with other intergradient in traditional prescription.


METHODS
A method for determination of fangchinoline and tetrandrine in rat plasma by using HPLC-MS has been developed and validated. The pharmacokinetics of two compounds and two compounds in the effective component group (ECG) of Xiaoxuming decoction were compared.


RESULTS
Compared with the single dose of compound experiment results, the t(max) of fangchinoline and tetrandrine were longer than those in the single dose of ECG experiment. At the meanwhile the rest parameter showed no significant difference.


CONCLUSIONS
Other components in the ECG of Xiaoxuming decoction delayed the absorption rate of fangchinoline and tetrandrine, the bioavailability of two compounds were the same as that of the single dose of compound experiment.
Li
Zhonghong
Z
Jiangsu Institute for Food and Drug Control, Nanjing 210008, China. lizhh402@sohu.com
Fan
Xialei
X
Cai
Meiming
M
Yang
Zhihong
Z
Ying
Jian
J
Qiang
Guifen
G
Du
Guanhua
G
D000818:Animals; D044182:Benzylisoquinolines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar
D044182:Benzylisoquinolines; D004365:Drugs, Chinese Herbal; C009438:tetrandrine; C060802:fangchinoline