title: Fetal genotyping for platelets antigens: a precise tool for alloimmune thrombocytopenia: case report and literature review.
abstract: BACKGROUND
  Maternal-fetal alloimmune thrombocytopenia complicates about 0.1% of all pregnancies and is associated with major fetal and neonatal morbidity and mortality, especially spontaneous central nervous system bleeding leading to death and neurological handicaps. Successful prevention and treatment depend on the identification of at-risk possible carriers of anti-platelet antibodies.
  
  
  METHODS
  We report a case of a mother with a previous child that developed neonatal hemorrhage; HPA-5b anti-platelet antibodies were detected post-natally. During the next pregnancy, fetal genotyping confirmed the presence of HPA-5b antigen; she was treated with weekly intravenous human immunoglobulin and oral prednisone. Pregnancy evolved without remarkable features and a full-term baby was delivered, with normal platelet counts.
  
  
  CONCLUSIONS
  Fetal alloimmune thrombocytopenia is a potentially lethal condition, but early detection and prevention lead to successful outcome in most cases.
authors.affiliation: Hematology and Hemotherapy Center, Centro de Atenção Integral à Saúde da Mulher (CAISM), Universidade Estadual de Campinas (Unicamp), Cidade Universitária, CEP 13084-881 Campinas, SP, Brazil. mlnomura@unicamp.br
authors.forename: Marcelo Luís
authors.initials: ML
authors.lastname: Nomura
authors.forename: Egle
authors.initials: E
authors.lastname: Couto
authors.forename: Beatriz Moraes
authors.initials: BM
authors.lastname: Martinelli
authors.forename: Maria Lourdes
authors.initials: ML
authors.lastname: Barjas-Castro
authors.forename: Ricardo
authors.initials: R
authors.lastname: Barini
authors.forename: Renato
authors.initials: R
authors.lastname: Passini Júnior
authors.forename: Vagner
authors.initials: V
authors.lastname: Castro
mesh_terms: D016824:Antigens, Human Platelet / Q000235:genetics / Q000276:immunology*; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D007231:Infant, Newborn; D007519:Isoantigens / Q000276:immunology*; D008297:Male; D011241:Prednisone / Q000008:administration & dosage; D011247:Pregnancy; D013921:Thrombocytopenia / Q000000981:diagnostic imaging / Q000235:genetics / Q000276:immunology* / Q000517:prevention & control; D016216:Ultrasonography, Prenatal
chemical_list: C451327:5b antigen; D016824:Antigens, Human Platelet; D016756:Immunoglobulins, Intravenous; D007519:Isoantigens; D011241:Prednisone