Pyroptosis - a cell death modality of its kind?
The term "pyroptosis" was originally introduced to describe a particular form of cell death in macrophages, which is induced by bacterial infection, is accompanied by caspase-1 activation and hence leads to the release of pyrogenic interleukins; however, it is still controversial whether pyroptosis - which can also be triggered by non-bacterial pathological stimuli - truly represents a cell death modality on its own or whether it constitutes a special case of apoptosis or necrosis.
Kepp
Oliver
O
INSERM, U848, Villejuif, France.
Galluzzi
Lorenzo
L
Zitvogel
Laurence
L
Kroemer
Guido
G
D000818:Animals; D016923:Cell Death / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D046912:Multiprotein Complexes / Q000276:immunology*
D046912:Multiprotein Complexes