Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives.
A number of N-(4,6-substituted diphenylpyrimidin-2-yl) semicarbazones (4a-t) were synthesized and tested for their anticonvulsant activity against the two seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ). All the synthesized compounds possessed the four essential pharmacophoric elements for good anticonvulsant activity. Most of the compounds displayed good anticonvulsant activity with lesser neurotoxicity. To assess the unwanted effects of the compounds on liver, estimation of enzymes and proteins was carried out.
Alam
Ozair
O
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India. dr.ozairalam@gmail.com
Mullick
Pooja
P
Verma
S P
SP
Gilani
Sadaf J
SJ
Khan
Suroor A
SA
Siddiqui
Nadeem
N
Ahsan
Waquar
W
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004357:Drug Synergism; D004827:Epilepsy / Q000188:drug therapy; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D009420:Nervous System / Q000187:drug effects; D011743:Pyrimidines / Q000737:chemistry*; D012664:Semicarbazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*
D000927:Anticonvulsants; D011743:Pyrimidines; D012664:Semicarbazones; C030986:pyrimidine