title: Oseltamivir-resistant 2009-2010 pandemic influenza A (H1N1) in an immunocompromised patient.
abstract: Although neuraminidase inhibitors are active against most 2009-2010 pandemic influenza A (H1N1) swine-origin strains, sporadic cases of oseltamivir resistance have been described. Since April 2009, 54 cases of oseltamivir-resistant H1N1 swine-origin have been reported in the USA (http://www.cdc.gov/flu/weekly/; accessed 1 February 2010). Approximately 1.4% of tested isolates are oseltamivir resistant. We report a patient with an underlying hematological malignancy who was hospitalized with influenza A (H1N1) swine-origin and whose strain developed oseltamivir resistance during therapy.
authors.affiliation: Division of Infection Disease, Department of Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA. pchan@lifespan.org
authors.forename: P A
authors.initials: PA
authors.lastname: Chan
authors.forename: N T
authors.initials: NT
authors.lastname: Connell
authors.forename: A M
authors.initials: AM
authors.lastname: Gabonay
authors.forename: B
authors.initials: B
authors.lastname: Westley
authors.forename: J M
authors.initials: JM
authors.lastname: Larkin
authors.forename: S P
authors.initials: SP
authors.lastname: LaRosa
authors.forename: K
authors.initials: K
authors.lastname: Chapin
authors.forename: L
authors.initials: L
authors.lastname: Mermel
mesh_terms: D000328:Adult; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D024882:Drug Resistance, Viral; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D016867:Immunocompromised Host; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000302:isolation & purification; D007251:Influenza, Human / Q000821:virology*; D053139:Oseltamivir / Q000494:pharmacology* / Q000627:therapeutic use; D014481:United States
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir