Cold agglutinin induced hemolysis in a newly diagnosed systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is a well-known autoimmune chronic inflammatory disease, which can virtually affect any organ system in the body. Although hemolytic anemia has been known to occur in <10% of SLE patients, they are usually mediated through warm antibodies. It is extremely rare to see cold antibody-mediated hemolytic anemia in SLE, and only few cases have been reported in literature to our knowledge. This is a unique case report of SLE associated with cold agglutinin hemolytic anemia in a patient presented with generalized tender lymphadenopathy and typical B-symptoms including fever, night sweats, and significant weight loss.
Srinivasan
Nandakumar
N
Oklahoma University of Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
Oswal
Alok
A
Garg
Sindhu
S
Nahar
Julie
J
Gosmonova
Albina
A
Nahar
Roopesh
R
D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis / Q000209:etiology*; D003450:Cryoglobulins / Q000009:adverse effects; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000628:therapy*
D003450:Cryoglobulins; C029443:cold agglutinins