title: Concomitant administration of recombinant PsaA and PCV7 reduces Streptococcus pneumoniae serotype 19A colonization in a murine model.
abstract: A murine colonization model was used to determine the effect of co-administering 7-valent polysaccharide-protein conjugate vaccine and pneumococcal surface adhesin A. Mice were challenged intranasally with either PCV7 serotypes, 4 or 14, or a non-PCV7 serotype, 19A. Post-challenge samples were evaluated for IgG antibody levels, opsonophagocytic activity, and nasopharyngeal colonization. No interference was observed between immune responses from the concomitant and individual immunizations. Concomitant immunizations reduced carriage for tested serotypes; largest reduction was observed for 19A. From these mouse studies, co-administering pneumococcal antigens appear to expand coverage and reduce colonization against a non-PCV7 serotype without inhibiting immunogenicity to other serotypes.
authors.affiliation: Division of Bacterial Diseases, Center of Disease Control and Prevention, 1600 Clifton Rd NE, MS G-05, Atlanta, GA 30333, USA. mwhaley@cdc.gov
authors.forename: Melissa J
authors.initials: MJ
authors.lastname: Whaley
authors.forename: Jacquelyn S
authors.initials: JS
authors.lastname: Sampson
authors.forename: Scott E
authors.initials: SE
authors.lastname: Johnson
authors.forename: Gowrisankar
authors.initials: G
authors.lastname: Rajam
authors.forename: Annie
authors.initials: A
authors.lastname: Stinson-Parks
authors.forename: Patricia
authors.initials: P
authors.lastname: Holder
authors.forename: Erica
authors.initials: E
authors.lastname: Mauro
authors.forename: Sandra
authors.initials: S
authors.lastname: Romero-Steiner
authors.forename: George M
authors.initials: GM
authors.lastname: Carlone
authors.forename: Edwin W
authors.initials: EW
authors.lastname: Ades
mesh_terms: D018829:Adhesins, Bacterial / Q000008:administration & dosage / Q000276:immunology*; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D002353:Carrier State / Q000517:prevention & control*; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D008074:Lipoproteins / Q000008:administration & dosage / Q000276:immunology*; D051379:Mice; D009895:Opsonin Proteins / Q000097:blood; D010587:Phagocytosis; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D013290:Streptococcal Infections / Q000517:prevention & control*; D013296:Streptococcus pneumoniae / Q000276:immunology*; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology
chemical_list: D018829:Adhesins, Bacterial; D000907:Antibodies, Bacterial; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D008074:Lipoproteins; D009895:Opsonin Proteins; D022242:Pneumococcal Vaccines; C085000:PsaA protein, Streptococcus; D017778:Vaccines, Combined