Do colloids in comparison to crystalloids for fluid resuscitation improve mortality?
Permanent neurological impairment or death arising from hospital-acquired hyponatremia in both children and adults is well documented. The choice of intravenous fluids for fluid resuscitation in critically ill patients is a top priority in evidence-based medicine. The question of whether colloids in comparison to crystalloids can improve mortality in such cases remains to be answered. Well powered, randomized clinical trials addressing the comparative efficacy of different types of intravenous fluids is a high priority as is the ethical justification for such trials. The understanding of the pathophysiological process serves important information on clinical practice.
Naing
Cho-Min
CM
School of Medical Sciences, International Medical University, Kuala Lumpur 57000, Malaysia. cho3699@gmail.com
Win
Daw-Khin
DK
D000328:Adult; D002648:Child; D003102:Colloids / Q000009:adverse effects / Q000627:therapeutic use*; D016638:Critical Illness / Q000401:mortality / Q000628:therapy*; D000077324:Crystalloid Solutions; D005440:Fluid Therapy / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007010:Hyponatremia / Q000209:etiology / Q000401:mortality; D007262:Infusions, Intravenous; D007552:Isotonic Solutions / Q000009:adverse effects / Q000627:therapeutic use*; D010952:Plasma Substitutes / Q000009:adverse effects / Q000627:therapeutic use*; D015532:Rehydration Solutions / Q000009:adverse effects; D012151:Resuscitation / Q000379:methods
D003102:Colloids; D000077324:Crystalloid Solutions; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D015532:Rehydration Solutions