[Presence of early risk markers of metabolic syndrome in prepubertal children with a history of intrauterine growth restriction].
BACKGROUND
Studies on people with low birth weight found metabolic syndrome associated with intrauterine growth restriction (IUGR).


OBJECTIVE
To study the presence of early risk markers of metabolic syndrome in a prepubertal population with IUGR.


METHODS
We studied 45 prepubertal children with a history of IUGR, without apparent disease, and 47 children in a control group. BMI, weight, height, and BMI Z score, and body fat mass were calculated. Basal glycemia, insulin, proinsulin, cortisol, serum lipids and uric acid levels were analyzed. Insulin sensitivity was calculated by QUICKI and insulin resistance by HOMA-IR.


RESULTS
Basal insulin levels were higher in the IUGR group compared with the controls (6.6 microU/ml vs. 4.4 microU/ml; p= 0.008). Similar results were found for the basal cortisol levels (18.8 ug/dl vs. 13.1 ug/dl; p= 0.006) and uric acid (4.2 mg/dl vs. 2.7 mg/dl; p= 0.0008). QUICKI index was lower in the IUGR group (2.06 vs. 2.86, p= 0.001). The IUGR children who developed obesity presented higher levels of proinsulin (26.04 ug/dl vs. 13.3 ug/dl; p= 0.05), insulin (11 microU/ml vs. 5.5 microU/ml, p= 0.005), and HOMA-IR (2.06 vs. 0.9, p= 0.004), and lower QUICKI (1.71 vs. 2.16, p= 0.01) than in the case of the IUGR children with appropriate weight; these differences weren't observed among the control group.


CONCLUSIONS
Children with IUGR, without apparent disease, showed metabolic changes that were expressed through risk markers of metabolic syndrome in childhood.
Krochik
Andrea G
AG
Servicio de Nutrición, Hospital Nacional de Pediatría Prof. Dr. Juan P. Garrahan. gabkro66@hotmail.com
Chaler
Eduardo A
EA
Maceiras
Mercedes
M
Aspres
Norma
N
Mazza
Carmen S
CS
D015415:Biomarkers / Q000097:blood; D002648:Child; D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D005260:Female; D005317:Fetal Growth Retardation; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D012307:Risk Factors
D015415:Biomarkers