title: [Correlation between the change in liver enzymology and the severity of acute graft-versus-host disease.].
abstract: OBJECTIVE
  To investigate the correlation between the change of liver enzymes and the severity of acute graft-versus-host disease (aGVHD).
  
  
  METHODS
  The liver enzyme and severity of aGVHD in 82 patients were analyzed retrospectively.
  
  
  RESULTS
  Among the 82 aGVHD patients, 7 developed grade I (18.3%), 47 grade II (57.3%), 13 grade III (15.9%) and 7 grade IV (8.5%) aGVHD. The elevation of ALT, AST and ALP was found in 49 (59.8%), 36(43.9%) and 8(9.8%)patients respectively. Among these patients, 34 (69.4%) were ALT > 40 U/L, 18 (50%) AST > 40 U/L and 4 (50%) ALP > 132 U/L before the onset of aGVHD. The elevation of ALT and AST was more common and the peak value was significantly higher in patients with grade III-IV aGVHD than with grade I-II aGVHD, but those of ALP showed no difference between the two groups. Compared with the patients without ALT elevation, the proportion of severe aGVHD was higher in patients with ALT elevation.
  
  
  CONCLUSIONS
  The alteration of liver enzymology is common in aGVHD and its level is correlated with the severity of aGVHD. Liver enzymes, especially the ALT, may be used as a predictor of aGVHD.
authors.affiliation: Institute of Hematology and People's Hospital of Peking University, Beijing 100044, China.
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Mo
authors.forename: Lan-Ping
authors.initials: LP
authors.lastname: Xu
authors.forename: Kai-Yan
authors.initials: KY
authors.lastname: Liu
authors.forename: Dai-Hong
authors.initials: DH
authors.lastname: Liu
authors.forename: Huan
authors.initials: H
authors.lastname: Chen
authors.forename: Feng-Rong
authors.initials: FR
authors.lastname: Wang
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Chen
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Huang
mesh_terms: D006086:Graft vs Host Disease; D006801:Humans; D008099:Liver; D012189:Retrospective Studies