Synthesis of 3-substituted indoles via reactive alkylideneindolenine intermediates.
Elimination of suitable leaving groups from 3-substituted indoles under basic or acidic conditions readily provides alkylideneindolenine intermediates that may react with a large variety of nucleophilic reagents. This article highlights some recent developments of this synthetic approach for the preparation of functionalized indole derivatives.
Palmieri
Alessandro
A
Dipartimento di Scienze Chimiche, Università di Camerino, via S.Agostino, 1, I-62032, Camerino, Italy.
Petrini
Marino
M
Shaikh
Rafik R
RR
D000473:Alkanes / Q000737:chemistry*; D055808:Drug Discovery; D007202:Indicators and Reagents / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology
D000473:Alkanes; D007202:Indicators and Reagents; D007211:Indoles