title: Exploring the antiperoxidative potential of morin on cyclophosphamide and flutamide-induced lipid peroxidation and changes in cholesterol profile in rabbit model.
abstract: Considering drug-induced lipid peroxidation as a possible mediator of drug-induced toxicity and exploiting the free radical scavenging action of antioxidants, the present study was designed to evaluate the antiperoxidative potential of morin on cyclophosphamide/flutamide-induced lipid peroxidation and also to evaluate the effect of morin on cyclophosphamide/flutamide-induced changes in cholesterol content in rabbit blood sample. This evaluation was done by measuring the malondialdehyde (MDA), reduced glutathione (GSH), 4-hydroxy-2-nonenal (4-HNE) and nitric oxide (NO) content of blood samples as markers of lipid peroxidation. In the cholesterol profile total cholesterol and high density lipoprotein cholesterol content of rabbit blood was determined. The study reveals the lipid peroxidation induction capacity of cyclophosphamide/flutamide and the antiperoxidative potential of morin on cyclophosphamide/flutamide-induced lipid peroxidation. It was also observed that morin has protective effect on cyclophosphamide/flutamide-induced changes in cholesterol content.
authors.affiliation: Division of Pharmaceutical Chemistry, Dr. B C Roy College of Pharmacy & Allied Health Sciences, Bidhannagar, Durgapur 713 206, India. supratimray_in@yahoo.co.in
authors.forename: Supratim
authors.initials: S
authors.lastname: Ray
authors.forename: Partha
authors.initials: P
authors.lastname: Chowdhury
authors.forename: Bibhas
authors.initials: B
authors.lastname: Pandit
authors.forename: Sarbani Dey
authors.initials: SD
authors.lastname: Ray
authors.forename: Sumit
authors.initials: S
authors.lastname: Das
mesh_terms: D000447:Aldehydes / Q000097:blood; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D003520:Cyclophosphamide / Q000633:toxicity*; D005419:Flavonoids / Q000494:pharmacology*; D005485:Flutamide / Q000633:toxicity*; D005978:Glutathione / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D023421:Models, Animal; D009569:Nitric Oxide / Q000097:blood; D016877:Oxidants / Q000633:toxicity*; D011817:Rabbits; D047309:Flavones
chemical_list: D000447:Aldehydes; D000970:Antineoplastic Agents; D000975:Antioxidants; D015415:Biomarkers; D002784:Cholesterol; D008076:Cholesterol, HDL; D003520:Cyclophosphamide; D005419:Flavonoids; D005485:Flutamide; D005978:Glutathione; D008315:Malondialdehyde; D009569:Nitric Oxide; D016877:Oxidants; C008548:morin; D047309:Flavones; C027576:4-hydroxy-2-nonenal