[CIinical study on treatment of Leber hereditary optic neuropathy].
OBJECTIVE
To investigate the effect of Wuzi Yanzong Decoction (WYD) in treating Leber hereditary optic neuropathy (LHON).


METHODS
Thirty patients of LHON up to the requirement were assigned to two groups, the treated group administered with WYD plus coenzyme Q10, and the control group with coenzyme Q10 alone, all for 3 months. Patients' visual acuity, visual field, vision evoked potential (VEP) and their Chinese medicine syndrome were observed before and after treatment.


RESULTS
After treatment, all the above-mentioned indexes were improved to some extents in the treated group, but showed no evident change in the control group excepting visual acuity, comparison between groups showed the differences were significant in all items.


CONCLUSIONS
WYD shows certain clinical therapeutic effect for treatment of LHON.
Li
Cheng-wu
CW
Wangling Hospital, China Academy of Chinese Medical Sciences, Beijing.
Zhuang
Zeng-yuan
ZY
Zhang
Shou-kang
SK
D000293:Adolescent; D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008297:Male; D029242:Optic Atrophy, Hereditary, Leber / Q000188:drug therapy* / Q000235:genetics; D008517:Phytotherapy; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000627:therapeutic use; D014792:Visual Acuity; D055815:Young Adult
D004365:Drugs, Chinese Herbal; C528421:wuzi yanzong; D014451:Ubiquinone; C024989:coenzyme Q10