title: Efficacy of low dose tamsulosin in medical expulsive therapy for ureteral stones in Japanese male patients: a randomized controlled study.
abstract: OBJECTIVE
  To evaluate the efficacy of low dose tamsulosin for facilitating spontaneous passage of ureteral stones in Japanese male patients.
  
  
  METHODS
  A total of 71 patients with symptomatic ureteral stones, 10 mm or smaller in size, were randomly allocated into groups 1 and 2. Group 1 received tamsulosin (0.2 mg/day) for a maximum of 4 weeks and group 2 received no medication. The primary endpoint was the stone expulsion rate and the secondary endpoints were stone expulsion time and analgesic use.
  
  
  RESULTS
  There were no significant differences between the groups in terms of age, stone size and location. The stone expulsion rate was significantly higher in group 1 than in group 2 (77% vs 50%, P = 0.002). No significant differences were noted in the stone expulsion time and analgesic use between the groups.
  
  
  CONCLUSIONS
  Low dose tamsulosin can significantly facilitate spontaneous passage of ureteral stones without significant side-effects in Japanese male patients.
authors.affiliation: Department of Urology, Tokyo Metropolitan Police Hospital, Tokyo, Japan. minerva@muc.biglobe.ne.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Kaneko
authors.forename: Hisashi
authors.initials: H
authors.lastname: Matsushima
authors.forename: Hirohiko
authors.initials: H
authors.lastname: Morimoto
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Tsuzaka
authors.forename: Yukio
authors.initials: Y
authors.lastname: Homma
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D000328:Adult; D044466:Asian People; D004305:Dose-Response Relationship, Drug; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012720:Severity of Illness Index; D013449:Sulfonamides / Q000008:administration & dosage* / Q000009:adverse effects; D000077409:Tamsulosin; D016896:Treatment Outcome; D014514:Ureteral Calculi / Q000188:drug therapy*
chemical_list: D000317:Adrenergic alpha-Antagonists; D013449:Sulfonamides; D000077409:Tamsulosin