[Selection of HIV escape mutants by CTL and adaptation of HIV to HLA class I].
HIV-1-specific CTLs, which can kill HIV-1-infected cells, play an important role in control HIV-1 replication. There are growing evidences that they select HIV-1 escape mutations so that escape HIV-1 mutants become dominant in the donors. A recent study analyzing approximately 2800 HIV-1 infected individuals in 9 different cohorts demonstrated that HIV escape mutants accumulated in the cohorts, demonstrating strong evidence of HIV adaptation to HLA at a population level. This process of viral adaptation may dismantle the well-established HLA associations with control of HIV infection that are linked to the availability of key epitopes, and highlights the challenge for a vaccine to keep pace with the changing immunological landscape presented by HIV.
Takiguchi
Masafumi
M
Division of Viral Immunology, Center for AIDS Research, Kumamoto University, 2-2-1 Honjo, Kumamoto. masafumi@kumamoto-u.ac.jp
D016915:AIDS Vaccines; D019143:Evolution, Molecular; D005805:Genes, MHC Class I; D015497:HIV-1 / Q000235:genetics* / Q000276:immunology* / Q000502:physiology; D006801:Humans; D009154:Mutation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014779:Virus Replication
D016915:AIDS Vaccines