Effects of marine n-3 fatty acids on circulating levels of soluble adhesion molecules in patients with chronic heart failure.
Inflammatory markers as circulating soluble cellular adhesion molecules (sCAMs) and high sensitive C-reactive protein (hsCRP) are elevated in patients with chronic heart failure (CHF), and may constitute an increased risk of adverse outcome. Marine n-3 polyunsaturated fatty acids ( n-3 PUFA) may have anti-inflammatory effect and reduce levels of sCAMs (soluble intercellular adhesion molecule-1 (sICAM-1), vascular adhesion molecule-1 (sVCAM-1), P-selectin) and hsCRP. In a randomized, controlled trial, 138 patients with NYHA class II-III CHF were allocated to receive a daily supplement of 0.9 g of n-3 PUFA or olive oil for 24 weeks. After supplementation, no significant changes occurred in sCAMs or hsCRP after adjusting for possible confounders. However, a significant reduction was observed in sP-selectin in patients receiving n-3 PUFA, but this result was only of borderline significance in a between-group analysis. In conclusion, a daily supplement with 0.9 g of n-3 PUFA does not significantly affect plasma levels of sCAMs or hs-CRP in patients with CHF. n-3 PUFA may reduce sP-selectin, indicating a possible effect on platelet (and endothelial) activation. The results also indicate that the low dose of n-3 PUFA used in many intervention trials does not have deleterious effects on sCAMs or hsCRP.
Eschen
O
O
Department of Cardiology, Center for Cardiovascular Research, Aalborg Sygehus, Aarhus University Hospital, Aalborg, Denmark. oe@dadlnet.dk
Christensen
J H
JH
LA Rovere
M T
MT
Romano
P
P
Sala
P
P
Schmidt
E B
EB
D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002097:C-Reactive Protein / Q000032:analysis; D002908:Chronic Disease; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology*; D005260:Female; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D000069463:Olive Oil; D019007:P-Selectin / Q000097:blood; D010938:Plant Oils / Q000494:pharmacology; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
D000893:Anti-Inflammatory Agents; D015525:Fatty Acids, Omega-3; D000069463:Olive Oil; D019007:P-Selectin; D010938:Plant Oils; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D002097:C-Reactive Protein