title: Placental vascular lesion differences in pregnancy-induced hypertension and normotensive fetal growth restriction.
abstract: OBJECTIVE
  Pregnancy-induced hypertension/preeclampsia (PIH) and fetal growth restriction (FGR) share a common placental origin. The pathologic classification that divides placental lesions to maternal or fetal origin was compared between these disorders.
  
  
  METHODS
  Placentas from pregnancies that were complicated by PIH, normotensive FGR, or by both (combined) were analyzed, and lesions were classified as those consistent with maternal under-perfusion and with fetal thromboocclusive disease.
  
  
  RESULTS
  Maternal vascular lesions were more common in the PIH group and combined group (61% and 59%, respectively), compared with the FGR group (16.2%; P < .001), and villous lesions were more common in the combined group, compared with the FGR and PIH groups (79.5%, 53.5%, and 46.9%, respectively; P = .004). Fetal villous changes were observed in 16.2% in the FGR group, compared with 3.1% in the PIH group (P = .03), and chronic villitis was 15.2% in the FGR group vs 1.6% in the PIH group (P = .004).
  
  
  CONCLUSIONS
  Placental lesions correspond with different clinical presentations.
authors.affiliation: Departments of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel. michalkovo@gmail.com
authors.forename: Michal
authors.initials: M
authors.lastname: Kovo
authors.forename: Letizia
authors.initials: L
authors.lastname: Schreiber
authors.forename: Avi
authors.initials: A
authors.lastname: Ben-Haroush
authors.forename: Suzanna
authors.initials: S
authors.lastname: Wand
authors.forename: Abraham
authors.initials: A
authors.lastname: Golan
authors.forename: Jacob
authors.initials: J
authors.lastname: Bar
mesh_terms: D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000473:pathology* / Q000503:physiopathology; D005865:Gestational Age; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000473:pathology* / Q000503:physiopathology; D008499:Medical Records; D018579:Patient Selection; D010920:Placenta / Q000098:blood supply* / Q000473:pathology* / Q000503:physiopathology; D011247:Pregnancy; D018709:Statistics, Nonparametric