title: [Experience with application of trospium chloride in patients with neurogenic detrusor overactivity].
abstract: Overactive bladder (OAB) is observed in such brain diseases as stroke, hypoxic ischemic encephalopathy, Parkinson's disease (PD), multiple sclerosis (MS). Trospium chloride (spasmex) was used in OAB patients with MS (n = 87), stroke (n = 83), encephalopathy (n = 47) and PD (n = 36) in doses from 15 to 45 mg/day in 2 to 36 month courses. The response with minimal side effects was achieved in 94% patients. In addition to basic effects, trospium chloride relieved spastic constipation in patients with stroke, hypersalivation in PD and anal incontinence in MS.
authors.forename: P G
authors.initials: PG
authors.lastname: Shvarts
authors.forename: A S
authors.initials: AS
authors.lastname: Kadykov
authors.forename: V V
authors.initials: VV
authors.lastname: Shvedkov
authors.forename: S L
authors.initials: SL
authors.lastname: Timerbaeva
authors.forename: E V
authors.initials: EV
authors.lastname: Polevaia
authors.forename: A N
authors.initials: AN
authors.lastname: Mulach
mesh_terms: D000328:Adult; D000368:Aged; D001561:Benzilates; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009662:Nortropanes / Q000008:administration & dosage* / Q000009:adverse effects; D010276:Parasympatholytics / Q000008:administration & dosage* / Q000009:adverse effects; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy* / Q000209:etiology; D053201:Urinary Bladder, Overactive / Q000188:drug therapy* / Q000209:etiology
chemical_list: D001561:Benzilates; D009662:Nortropanes; D010276:Parasympatholytics; C003330:trospium chloride