A palmitoyl conjugate of insect pentapeptide Yamamarin arrests cell proliferation and respiration.
A palmitoyl conjugate of an insect pentapeptide that occurs in diapausing insects causes a reversible cell-cycle arrest and suppresses mitochondrial respiration. This peptide compound also causes growth arrest in murine leukemic cell line expressing human gene Bcr/Abl and a farnesoyl peptide induces embryonic diapause in Bombyx mori. These results demonstrate that the insect peptide compounds can lead to the understanding of a common pathway in developmental arrest in animals and may provide a new peptidominetic analog in the development of biopharmaceuticals and pest management.
Sato
Yosinori
Y
Department of Agro-Bioscience, Faculty of Agriculture, Iwate University, Morioka 020-8550, Japan.
Yang
Ping
P
An
Ying
Y
Matsukawa
Kazushige
K
Ito
Kikukatsu
K
Imanishi
Shigeo
S
Matsuda
Hirokazu
H
Uchiyama
Yusuke
Y
Imai
Kunio
K
Ito
Shigeki
S
Ishida
Yoji
Y
Suzuki
Koichi
K
D000818:Animals; D012831:Bombyx; D002453:Cell Cycle / Q000187:drug effects; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D019069:Cell Respiration / Q000187:drug effects*; D002478:Cells, Cultured; D004330:Drosophila; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics / Q000378:metabolism; D019476:Insect Proteins / Q000737:chemistry*; D051379:Mice; D008858:Microscopy, Phase-Contrast; D015394:Molecular Structure; D009036:Moths; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
D019476:Insect Proteins; D009842:Oligopeptides; D016044:Fusion Proteins, bcr-abl