Copper-mediated N-heteroarylation of primary sulfonamides: synthesis of mono-N-heteroaryl sulfonamides.
We describe the coupling of primary sulfonamides and various halogenated heterocyclic cores, with an emphasis on 2-heteroaryl halides, via copper catalysis. These studies enabled the synthesis of many new mono-N-heteroaryl sulfonamides. The electronic factors that influence the course of the reaction have also been investigated.
Baffoe
Jonathan
J
Novartis Institutes for Biomedical Research, Inc. Oncology, Global Discovery Chemistry, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Hoe
Madelene Y
MY
Touré
B Barry
BB
D003300:Copper / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry*
D007454:Iodides; D013449:Sulfonamides; D003300:Copper; C073870:cuprous iodide