title: Influence of donor age on renal graft function in first seven post transplant days.
abstract: Increasing gap between demand and availability of human kidneys for transplantation has forced a re-evaluation of the limits on donor age acceptability. The present study included 74 patients who underwent kidney transplantation in University Clinical Centre Tuzla. In an observational cohort study we assessed impact of donor age on post transplant renal function by analyzing following parameters: 24 hour urine output, creatinine clearance (Cr Cl) and glomerular filtration rate (GFR). Depending on donor age recipients were allocated in to two groups. Group I included patients who received renal graft from donors age up to 55 years, and Group II encountered recipients who received renal graft from donors older than 55 years. Our goal was to determine whether donor age over 55 years significantly diminishes renal graft function in first seven post transplant days. No statistically significant difference was found between Group I and II regarding 24 hour urine output. From second to fifth postoperative day creatinine clearance values were higher in the group of patients who received kidney from donors older than 55 years (47+/-19, 1 vs. 44, 4+/-20, 8). On the fifth, sixth and seventh post operative day GFR was significantly higher in patients who received renal graft from donors age up to 55 years (p<0, 0161). Our data showed no significant difference in observed variables between the two groups, thus indicating that utilization of renal grafts from donors' age > 55 years is acceptable and may considerably expand the donor pool.
authors.affiliation: Clinic for of Anaesthesiology and Reanimatology, University Clinical Centre Tuzla, Trnovac bb, 75 000 Tuzla, Bosnia and Herzegovina.
authors.forename: Semir
authors.initials: S
authors.lastname: Imamovic
authors.forename: Farid
authors.initials: F
authors.lastname: Ljuca
authors.forename: Goran
authors.initials: G
authors.lastname: Imamovic
authors.forename: Fatima
authors.initials: F
authors.lastname: Iljazagic Halilovic
authors.forename: Alisa
authors.initials: A
authors.lastname: Krdzalic
authors.forename: Sefik
authors.initials: S
authors.lastname: Hasukic
authors.forename: Deso
authors.initials: D
authors.lastname: Mesic
authors.forename: Enver
authors.initials: E
authors.lastname: Zerem
mesh_terms: D000328:Adult; D000367:Age Factors; D015331:Cohort Studies; D003404:Creatinine / Q000378:metabolism; D051799:Delayed Graft Function / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D051437:Renal Insufficiency / Q000175:diagnosis / Q000209:etiology*; D012307:Risk Factors; D014019:Tissue Donors; D014554:Urination
chemical_list: D003404:Creatinine