title: Fatal congenital tuberculosis due to a Beijing strain in a premature neonate.
abstract: Congenital tuberculosis (TB) remains a rare disease but is fatal if untreated. Early detection is difficult because of the non-specific nature of the symptoms in TB during pregnancy and infancy. This report summarizes a case of congenital TB in a very premature infant, born at 25 weeks gestation. Miliary TB was diagnosed in the mother when the neonate was 20 days old. Antituberculous therapy allowed a rapid improvement in the mother. The infant died at 27 days old. A Beijing genotype strain of Mycobacterium tuberculosis was isolated both in the mother, from pulmonary and urine specimens, and in the infant, from peritoneal fluid.
authors.affiliation: Faculté de Médecine et des Sciences de la Santé, Université de Brest, EA 3882, 29200 Brest, France.|Laboratoire de Microbiologie, Centre Hospitalier Universitaire La Cavale Blanche, Boulevard Tanguy Prigent, 29609 Brest cedex, France.
authors.forename: M L
authors.initials: ML
authors.lastname: Abalain
authors.affiliation: Laboratoire de Microbiologie, Centre Hospitalier Universitaire La Cavale Blanche, Boulevard Tanguy Prigent, 29609 Brest cedex, France.
authors.forename: O
authors.initials: O
authors.lastname: Petsaris
authors.affiliation: Faculté de Médecine et des Sciences de la Santé, Université de Brest, EA 3882, 29200 Brest, France.|Laboratoire de Microbiologie, Centre Hospitalier Universitaire La Cavale Blanche, Boulevard Tanguy Prigent, 29609 Brest cedex, France.
authors.forename: G
authors.initials: G
authors.lastname: Héry-Arnaud
authors.affiliation: Service d'Anatomo-Pathologie, Centre Hospitalier Universitaire Morvan, 2 Avenue Foch, 29609 Brest cedex, France.
authors.forename: P
authors.initials: P
authors.lastname: Marcorelles
authors.affiliation: Service de Pneumologie, Centre Hospitalier Universitaire La Cavale Blanche, 29609 Brest cedex, France.
authors.forename: F
authors.initials: F
authors.lastname: Couturaud
authors.affiliation: Service de Réanimation Pédiatrique, Centre Hospitalier Universitaire Morvan, 2 Avenue Foch, 29609 Brest cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Dobrzynski
authors.affiliation: Faculté de Médecine et des Sciences de la Santé, Université de Brest, EA 3882, 29200 Brest, France.|Laboratoire de Microbiologie, Centre Hospitalier Universitaire La Cavale Blanche, Boulevard Tanguy Prigent, 29609 Brest cedex, France.
authors.forename: C
authors.initials: C
authors.lastname: Payan
authors.affiliation: Laboratoire de Référence des Mycobactéries, Institut Pasteur, 75015 Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Gutierrez
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D001202:Ascitic Fluid / Q000382:microbiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D009169:Mycobacterium tuberculosis / Q000145:classification* / Q000302:isolation & purification*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis / Q000188:drug therapy; D047928:Premature Birth; D013183:Sputum / Q000382:microbiology; D014376:Tuberculosis / Q000175:diagnosis* / Q000382:microbiology* / Q000635:transmission; D014556:Urine / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents