title: Expression analysis of suppression of tumorigenicity 13 gene in patients with Parkinson's disease.
abstract: Parkinson's disease (PD) is the second most common progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons. Detecting changes in gene expression in untreated de novo patients with PD is important for understanding disease pathogenesis and for identifying biomarkers for preclinical stage of PD. In this study we investigate ST13 gene expression in the peripheral blood of different groups of patients with neurological diseases using reverse transcription reaction and real-time polymerase chain reaction (PCR). Our results suggest that the expression levels of ST13 cannot serve as a biomarker for early stages of PD.
authors.affiliation: Institute of Molecular Genetics RAS, 2 Kurchatov Sq, Moscow 123182, Russia.
authors.forename: Maria I
authors.initials: MI
authors.lastname: Shadrina
authors.forename: Elena V
authors.initials: EV
authors.lastname: Filatova
authors.forename: Aleksey V
authors.initials: AV
authors.lastname: Karabanov
authors.forename: Peter A
authors.initials: PA
authors.lastname: Slominsky
authors.forename: Sergey N
authors.initials: SN
authors.lastname: Illarioshkin
authors.forename: Irina A
authors.initials: IA
authors.lastname: Ivanova-Smolenskaya
authors.forename: Svetlana A
authors.initials: SA
authors.lastname: Limborska
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D002352:Carrier Proteins / Q000096:biosynthesis* / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood*; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis* / Q000097:blood; D018832:Molecular Chaperones
chemical_list: D015415:Biomarkers; D002352:Carrier Proteins; D025521:Tumor Suppressor Proteins; C101119:ST13 protein, human; D018832:Molecular Chaperones