L-Histidine and L-arginine promote Knoevenagel reaction in water.
Histidine and arginine were applied to the synthesis of trisubstituted alkenes through a condensation of an aldehyde with an activated CH-acid such as ethyl cyanoacetate, malononitrile, acetyl acetone or ethyl acetoacetate during 5-12 h in water at room temperature.
Rahmati
Abbas
A
Department of Chemistry, University of Isfahan, P. O. Box 81746-73441, Isfahan, Iran. a.rahmati@sci.ui.ac.ir
Vakili
Kobra
K
D000447:Aldehydes / Q000737:chemistry; D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry; D001120:Arginine / Q000737:chemistry*; D055598:Chemical Phenomena; D006639:Histidine / Q000737:chemistry*; D008956:Models, Chemical; D014867:Water / Q000737:chemistry
D000447:Aldehydes; D000475:Alkenes; D014867:Water; D006639:Histidine; D001120:Arginine