title: [Determinants of long-term survival after pancreaticoduodenectomy for ampulla of Vater carcinoma].
abstract: OBJECTIVE
  To investigate the determinants of long-term survival for ampulla of Vater carcinoma treated by pancreaticoduodenectomy.
  
  
  METHODS
  A total of 77 patients with ampulla of Vater carcinoma undergoing pancreaticoduodenectomy were reviewed. Kaplan-Meier method was used to analyze the survival rate. Independent t test was used for statistical comparison and COX regression model for multivariate analysis.
  
  
  RESULTS
  No patient died as a result of surgery. The overall 5-year survival was 40.7%. Univariate analysis showed that perioperative serum carcinoembryonic antigen (CEA) level (P = 0.012), tumor invasion depth (P = 0.000), UICC stage (P = 0.000) and tumor size (P = 0.001) were significant prognostic factors of ampulla of Vater carcinoma; in multivariate analysis, only the tumor size (P = 0.000) was an independent prognostic factor of ampulla of Vater carcinoma.
  
  
  CONCLUSIONS
  Pancreaticoduodenectomy is associated with significant survival. Tumor size is the most important influencing factor of outcome after pancreaticoduodenectomy; in addition, perioperative serum CEA level, tumor invasion depth and UICC stage may also influence the survival rate, there exists a need for further follow-up studies.
authors.affiliation: Department of Hepatobiliary Surgery, General Hospital of PLA, Beijing 100853, China.
authors.forename: Ji-ye
authors.initials: JY
authors.lastname: Chen
authors.forename: Shou-wang
authors.initials: SW
authors.lastname: Cai
authors.forename: Wen-zhi
authors.initials: WZ
authors.lastname: Zhang
authors.forename: Xiao-qiang
authors.initials: XQ
authors.lastname: Huang
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Yong-liang
authors.initials: YL
authors.lastname: Chen
authors.forename: Wen-bin
authors.initials: WB
authors.lastname: Ji
authors.forename: Xian-jie
authors.initials: XJ
authors.lastname: Shi
authors.forename: Ming-yi
authors.initials: MY
authors.lastname: Chen
authors.forename: Zhi-wei
authors.initials: ZW
authors.lastname: Liu
authors.forename: Xiang-qian
authors.initials: XQ
authors.lastname: Zhao
authors.forename: Yu-quan
authors.initials: YQ
authors.lastname: Feng
authors.forename: Zhi-qiang
authors.initials: ZQ
authors.lastname: Huang
authors.forename: Jia-hong
authors.initials: JH
authors.lastname: Dong
mesh_terms: D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000601:surgery*; D002277:Carcinoma / Q000401:mortality / Q000601:surgery*; D003138:Common Bile Duct Neoplasms / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016577:Pancreaticoduodenectomy / Q000401:mortality*; D011379:Prognosis; D016016:Proportional Hazards Models; D015996:Survival Rate