title: [Follow-up study of patients with chronic motor axonal neuropathy].
abstract: OBJECTIVE
  To study the characteristic of chronic motor axonal neuropathy and the prognosis of it.
  
  
  METHODS
  16 chronic motor axonal neuropathy (CMAN) patients were diagnosed by clinical manifestation and neurophysiologic manifestation. Follow-up study was done including living state, medicine they taken, change of physical sign and motor unit number estimation. 60 patients with amyotrophic lateral sclerosis were studies at the same time. The prognosis of these patients was compared.
  
  
  RESULTS
  After being treated with intravenous immunoglobulin therapy, the patients with CMAN showed a good clinical recovery except 6 patients who had the characteristic of ALS in the 18 months follow-up study, and the MUNE changed from 68 +/- 17 to 154 +/- 25. On the contrary, the patients with ALS had worse clinical manifestation, and the MUNE changed from 64 +/- 6 to 55 +/- 9.
  
  
  CONCLUSIONS
  Immunological factor may be involved in the mechanism of chronic motor axonal neuropathy which has a better prognosis and is difficult to differentiate from amyotrophic lateral sclerosis in the earlier stage.
authors.affiliation: Department of Neurology, Peking University Third Hospital, Beijing 100191, China.
authors.forename: Ying-sheng
authors.initials: YS
authors.lastname: Xu
authors.forename: Min
authors.initials: M
authors.lastname: Deng
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Ju-yang
authors.initials: JY
authors.lastname: Zheng
authors.forename: Shuo
authors.initials: S
authors.lastname: Zhang
authors.forename: De-xuan
authors.initials: DX
authors.lastname: Kang
authors.forename: Dong-sheng
authors.initials: DS
authors.lastname: Fan
mesh_terms: D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis; D002452:Cell Count; D004576:Electromyography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D009046:Motor Neurons / Q000166:cytology*; D005719:gamma-Globulins / Q000627:therapeutic use
chemical_list: D005719:gamma-Globulins