title: Monoclonal antibody MG7 as a screening tool for gastric cancer.
abstract: MG7 is a gastric cancer-specific MAb with high specificity and sensitivity. By using MG7 MAb, we found that MG7Ag was increasingly detected in superficial gastritis, atrophic gastritis, intestinal metaplasia, atypical hyperplasia, and gastric cancer, indicating that MG7Ag could be considered an important early warning molecule of gastric cancer and MG7 MAb could be used as a tool for screening gastric cancer. We have developed a new and sensitive system, immuno-realtime PCR, for detection of MG7Ag in the serum. The use of qIPCR assays enabled the detection of MG7Ag in complex biological samples that were poorly accessible by conventional immunoassays.
authors.affiliation: State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi Province, China.
authors.forename: Zheng
authors.initials: Z
authors.lastname: Chen
authors.forename: Liu
authors.initials: L
authors.lastname: Hong
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.forename: Daorong
authors.initials: D
authors.lastname: Peng
authors.forename: Quanjiang
authors.initials: Q
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Jin
authors.forename: Taidong
authors.initials: T
authors.lastname: Qiao
authors.forename: Kaichun
authors.initials: K
authors.lastname: Wu
authors.forename: Daiming
authors.initials: D
authors.lastname: Fan
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000276:immunology / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005756:Gastritis / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D006965:Hyperplasia / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D007124:Immunoenzyme Techniques; D008679:Metaplasia / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D010957:Plasmids; D016133:Polymerase Chain Reaction; D011230:Precancerous Conditions / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D013274:Stomach Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; C508753:MG7 antigen, human; C503210:MG7 monoclonal antibody