[The important role of GLUT2 in intestinal sugar transport and absorption].
The classical model of sugar absorption indicates that Na+ -glucose cotransporter, SGLT1 transports glucose from intestinal lumen to cytosol and GLUT2 transports glucose from cytosol to the blood. Recent evidence indicates that GLUT 2 is rapidly inserted into the apical membrane after a meal. Intestinal glucose absorption by the apical GLUT2 pathway can be 3 to 5-times greater then by SGLT1 et the high concentration of sugar. Apical GLUT2 insertion is regulated by pathway of calcium absorption through L-type channel Ca(v)1.3, activation of sweet taste receptors (T1R2/F1R3) and endocrine and paracrine hormones (especially insulin and GLP-2).
Stelmańska
Ewa
E
Katedra i Zaklad Biochemii, Gdański Uniwersytet Medyczny, Gdańsk, Poland. bori@amg.gda.pl
D000327:Adsorption; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D000067758:Glucagon-Like Peptide-2 Receptor; D005947:Glucose / Q000378:metabolism*; D051273:Glucose Transporter Type 2 / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007408:Intestinal Absorption / Q000502:physiology; D007413:Intestinal Mucosa / Q000378:metabolism*; D018027:Receptors, Glucagon / Q000378:metabolism
D000067758:Glucagon-Like Peptide-2 Receptor; D051273:Glucose Transporter Type 2; D007328:Insulin; D018027:Receptors, Glucagon; D005947:Glucose; D002118:Calcium