title: Room temperature cross-coupling of highly functionalized organozinc reagents with thiomethylated N-heterocycles by nickel catalysis.
abstract: A variety of thiomethyl-substituted N-heterocycles such as pyridines, isoquinolines, pyrimidines, pyrazines, pyridazines, quinazolines, triazines, benzothiazoles, or benzoxazoles undergo smooth Ni-catalyzed cross-coupling reactions with functionalized aryl-, heteroaryl-, alkyl-, and benzylic zinc reagents using an inexpensive Ni(acac)(2)/DPE-Phos catalytic system at 25 degrees C.
authors.affiliation: Department Chemie, Ludwig-Maximilians-University, Butenandtstr. 5-13, Munich, Germany.
authors.forename: Laurin
authors.initials: L
authors.lastname: Melzig
authors.forename: Albrecht
authors.initials: A
authors.lastname: Metzger
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel