title: Flow induced dispersion analysis quantifies noncovalent interactions in nanoliter samples.
abstract: Flow Induced Dispersion Analysis (FIDA) is presented as a new approach to characterize noncovalent interactions. The new method only requires nanoliter samples, is easy to implement, and also provides diffusivities of the free analyte and the formed complex. The technique is based on signal analysis of temporal variances obtained for pressure driven flows in micrometer sized fused silica capillaries.
authors.affiliation: Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark. hj@farma.ku.dk
authors.forename: Henrik
authors.initials: H
authors.lastname: Jensen
authors.forename: Jesper
authors.initials: J
authors.lastname: Østergaard
mesh_terms: D002851:Chromatography, High Pressure Liquid; D017022:Flow Injection Analysis / Q000379:methods*; D046210:Microfluidic Analytical Techniques; D009284:Naphthols / Q000737:chemistry; D009288:Naproxen / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D009284:Naphthols; D004364:Pharmaceutical Preparations; D009288:Naproxen