Analysis of association between bleomycin hydrolase and apolipoprotein E polymorphism in Alzheimer's disease.
Alzheimer's disease (AD) is the leading cause of dementia. Several studies indicate a possible relationship between different genes and Alzheimer's disease. To further investigate, we have analyzed the association between the bleomycin hydrolase (BLMH) and apolipoprotein E (ApoE) polymorphisms in 93 AD patients and age- and sex-matched 113 controls from the Tunisian population. The frequency of ApoE epsilon 4 allele was found to differ significantly in AD patients compared to the control [29.5% vs. 8.8 (χ (2) = 26, df = 1, p < 0.001)] leading to an increased risk of AD in subjects with this allele (OR = 3.29, 95% CI = 1.7-6.5; p = 0.001]. This risk was found to decrease from OR = 8.4, CI = 3.3-23; p < 0.001 in subjects less than 75 years old to OR = 1.2, CI = 1.031-14; p = 0.0297 in subjects 75 years and older. No association was observed between carrying the BLMH-G genotype and AD in ε4 negative or positive subjects.
Smach
Mohamed Ali
MA
Department of Biochemistry, Faculty of Medicine of Sousse, Sousse, Tunisia. dalifms@yahoo.fr
Charfeddine
Bassem
B
Lammouchi
Turkia
T
Othman
Leila Ben
LB
Letaief
Afef
A
Nafati
Souhir
S
Dridi
Hedi
H
Bennamou
Soufien
S
Limem
Khalifa
K
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000201:enzymology* / Q000235:genetics*; D053327:Apolipoprotein E4 / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics*; D003546:Cysteine Endopeptidases / Q000235:genetics*; D005260:Female; D006580:Genetic Carrier Screening; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D014416:Tunisia
D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D003546:Cysteine Endopeptidases; C031262:bleomycin hydrolase