title: Malignant peripheral nerve sheath tumor associated with neurofibromatosis type 1, with metastasis to the heart: a case report.
abstract: A rare case is presented of a 61-year-old man with a malignant peripheral nerve sheath tumor associated with neurofibromatosis type 1, with metastasis to the heart. The primary tumor originated in the right thigh in 1982. Since then, the patient has had repeated local recurrences in spite of repeated surgical treatment and adjuvant chemotherapy. He has developed previous metastases of the lung and heart. The patient died of cardiac involvement.
authors.affiliation: Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari, Osaka, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Kitamura
authors.forename: Naoki
authors.initials: N
authors.lastname: Wada
authors.forename: Shigenori
authors.initials: S
authors.lastname: Nagata
authors.forename: Norishige
authors.initials: N
authors.lastname: Iizuka
authors.forename: Yu-Fen
authors.initials: YF
authors.lastname: Jin
authors.forename: Miki
authors.initials: M
authors.lastname: Tomoeda
authors.forename: Michiko
authors.initials: M
authors.lastname: Yuki
authors.forename: Norifumi
authors.initials: N
authors.lastname: Naka
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Araki
authors.forename: Chikao
authors.initials: C
authors.lastname: Yutani
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tomita
mesh_terms: D000671:Amputation, Surgical; D001344:Autopsy; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D017809:Fatal Outcome; D006338:Heart Neoplasms / Q000556:secondary* / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018317:Nerve Sheath Neoplasms / Q000556:secondary* / Q000628:therapy; D009456:Neurofibromatosis 1 / Q000473:pathology* / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000473:pathology* / Q000628:therapy; D013848:Thigh; D016896:Treatment Outcome