The association between follicular size on human chorionic gonadotropin day and pregnancy rate in clomiphene citrate treated polycystic ovary syndrome patients.
OBJECTIVE
To examine leading follicle size on human chorionic gonadotropin (hCG) day and pregnancy rate in anovulatory polycystic ovary syndrome (PCOS) patients treated with clomiphene citrate (CC).


METHODS
Retrospective cohort study.


METHODS
Fertility clinics in women's health centers.


METHODS
Data on 291 infertile women with PCOS and irregular cycles who underwent 685 CC treatment cycles were used. Only cycles with one or two follicles >14 mm were included. hCG was administered once the leading follicle reached the size of 17-24 mm.


METHODS
Pregnancy rates in relation to leading follicle size.


RESULTS
Mono/bi-follicular response was observed in 418 cycles. Pregnancy rates were highest (13.6-18.6%) when hCG was administered in the presence of an 18-22 mm follicle, lowest with 17 mm, 23 mm and 24 mm (8.8%, 8.8% and 5.7%, respectively). No differences were observed in pregnancy rates between mono and bi-follicular cycles.


CONCLUSIONS
In CC treatment, hCG should be administered when follicular size is at the range of 18-22 mm.
Farhi
Jacob
J
Fertility Clinics, Ashdod and Holon Women's Health Centers, Clalit Medical Services, Rabin Medical Center, Petach Tikva, Israel. j_farhi@yahoo.com
Orvieto
Raoul
R
Gavish
Oz
O
Homburg
Roy
R
D000328:Adult; D016009:Chi-Square Distribution; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D002996:Clomiphene / Q000627:therapeutic use*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D006801:Humans; D006080:Ovarian Follicle / Q000502:physiology*; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies
D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D002996:Clomiphene