title: Does the histamine H4 receptor have a pro- or anti-inflammatory role in murine bronchial asthma?
abstract: The histamine H4 receptor is expressed preferentially on immune cells, indicating a possible role of the H4 receptor in inflammation. Studies of inflammation in several animal models point to a pro-inflammatory function of the H4 receptor. However, studies on experimental murine bronchial asthma yielded conflicting results, a fact which is neglected in most H4 receptor publications. Therefore, the present review critically analyzes available data on the role of the H4 receptor in the murine bronchial asthma model.
authors.affiliation: Institute of Pharmacology, Hannover Medical School, Hannover, Germany. neumann.detlef@mh-hannover.de
authors.forename: Detlef
authors.initials: D
authors.lastname: Neumann
authors.forename: Silke
authors.initials: S
authors.lastname: Beermann
authors.forename: Roland
authors.initials: R
authors.lastname: Seifert
mesh_terms: D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D004195:Disease Models, Animal; D006632:Histamine / Q000502:physiology; D006801:Humans; D007211:Indoles / Q000494:pharmacology; D007249:Inflammation / Q000503:physiopathology; D051379:Mice; D010879:Piperazines / Q000494:pharmacology; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects / Q000502:physiology*; D011968:Receptors, Histamine / Q000187:drug effects / Q000502:physiology*; D018100:Receptors, Histamine H3 / Q000502:physiology; D000074040:Receptors, Histamine H4
chemical_list: C498829:Hrh4 protein, mouse; D007211:Indoles; D010879:Piperazines; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D018100:Receptors, Histamine H3; D000074040:Receptors, Histamine H4; C484309:1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine; D006632:Histamine