title: New observations from MR velocity-encoded flow measurements concerning diastolic function in constrictive pericarditis.
abstract: OBJECTIVE
  To assess diastolic function in patients with constrictive pericarditis (CP) by using velocity-encoded flow measurements at the atrioventricular valves and to evaluate whether conclusions regarding increased ventricular pressure can be drawn.
  
  
  METHODS
  Twenty-two patients with CP and 20 healthy subjects were examined on a 1.5-T MR system. In addition to evaluation of pericardial thickness, ventricular volumes and septal movement, velocity-encoded flow measurements were performed at the level of the atrioventricular valves for assessment of diastolic function. Amplitudes of the e- and a-waves were measured and e- to a-wave ratios were calculated. The correlation of transtricuspid e- to a-wave ratios and right ventricular end-diastolic pressures (RVEDP) was calculated.
  
  
  RESULTS
  Right ventricular volumes were significantly smaller in patients with CP (p < 0.001). Abnormal septal movement was detected in all patients except one with CP and in none of the healthy subjects. In patients with CP mean transtricuspid e- to a-wave ratios were significantly smaller compared with healthy subjects. Individual transtricuspid e- to a-wave ratios were highly correlated with RVEDP (r = 0.6, p = 0.01).
  
  
  CONCLUSIONS
  An elaborate MR examination can identify patients with CP. Velocity-encoded flow measurements with calculation of transtricuspid e- to a-wave ratios are a valuable tool for detection of diastolic dysfunction in patients with CP. The value of e- to a-wave ratios may indicate elevated RVEDP.
authors.affiliation: Department of Clinical Radiology, University Hospitals-Campus Grosshadern, Ludwig-Maximilian University, Munich, Germany. Kerstin.Bauner@med.uni-muenchen.de
authors.forename: Kerstin
authors.initials: K
authors.lastname: Bauner
authors.forename: A
authors.initials: A
authors.lastname: Horng
authors.forename: Ch
authors.initials: Ch
authors.lastname: Schmitz
authors.forename: M
authors.initials: M
authors.lastname: Reiser
authors.forename: A
authors.initials: A
authors.lastname: Huber
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D055420:Perfusion Imaging / Q000379:methods*; D010494:Pericarditis, Constrictive / Q000150:complications* / Q000175:diagnosis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis* / Q000209:etiology*