Nuclear receptors, inflammation, and liver disease: insights for cholestatic and fatty liver diseases.
Members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors are players of substantial relevance in the regulation of hepatic gene expression. NRs direct normal physiology and metabolism, adaptations to liver disease, and responses to inflammation and toxins.They also contribute to the regenerative response. In this review, we summarize currently available experimental and clinical data, focusing on the role of NRs in cholestasis and nonalcoholic fatty liver disease (NAFLD). We also highlight the potential of NRs as targets for safe and effective therapeutic interventions.
Arrese
M
M
Department of Gastroenterology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Karpen
S J
SJ
D000818:Animals; D002779:Cholestasis / Q000188:drug therapy / Q000503:physiopathology*; D016503:Drug Delivery Systems; D005234:Fatty Liver / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D018160:Receptors, Cytoplasmic and Nuclear / Q000187:drug effects / Q000378:metabolism*
D018160:Receptors, Cytoplasmic and Nuclear