title: Disease burden of post-infectious irritable bowel syndrome in The Netherlands.
abstract: Post-infectious irritable bowel syndrome (PI-IBS) has been established as a sequel of infectious intestinal disease (IID). The aim of this study was to estimate the burden of PI-IBS caused by the pathogens Campylobacter, Salmonella and Shigella, and to compare this with other outcomes associated with these pathogens. The attributable risk of PI-IBS due to bacterial pathogens was calculated and linked to national data on gastroenteritis incidence and measures for severity and duration of illness in order to estimate the burden of PI-IBS. One year post-infection, IBS developed in 9% of patients with bacterial IID. The burden of PI-IBS adds over 2300 disability adjusted life years to the total annual disease burden for the selected pathogens. PI-IBS is a frequent sequel of IID, resulting in a considerable disease burden compared to other outcomes. If this relationship is not considered, this will result in an underestimation of the disease burden of IID.
authors.affiliation: Laboratory for Zoonoses and Environmental Microbiology, Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, The Netherlands. j.haagsma@erasmusmc.nl
authors.forename: J A
authors.initials: JA
authors.lastname: Haagsma
authors.forename: P D
authors.initials: PD
authors.lastname: Siersema
authors.forename: N J
authors.initials: NJ
authors.lastname: De Wit
authors.forename: A H
authors.initials: AH
authors.lastname: Havelaar
mesh_terms: D001424:Bacterial Infections / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D005759:Gastroenteritis / Q000150:complications* / Q000453:epidemiology / Q000382:microbiology; D006801:Humans; D015994:Incidence; D043183:Irritable Bowel Syndrome / Q000453:epidemiology* / Q000209:etiology*; D009426:Netherlands / Q000453:epidemiology; D011788:Quality of Life; D019057:Quality-Adjusted Life Years; D012307:Risk Factors