title: Semi-automatic tumour segmentation by selective navigation in a three-parameter volume, obtained by voxel-wise kinetic modelling of 11C-acetate.
abstract: Positron emission tomography (PET) is increasingly used for delineation of tumour tissue in, for example, radiotherapy treatment planning. The most common method used is to outline volumes with a certain per cent uptake over background in a static image. However, PET data can also be collected dynamically and analysed by kinetic models, which potentially represent the underlying biology better. In the present study, a three-parameter kinetic model was used for voxel-wise evaluation of (11)C-acetate data of head/neck tumours. These parameters which represent the tumour blood volume, the uptake rate and the clearance rate of the tissue were derived for each voxel using a linear regression method and used for segmentation of active tumour tissue. This feasibility study shows that it is possible to segment images based on derived model parameters. There is, however, room for improvements concerning the PET data acquisition, noise reduction and the kinetic modelling. In conclusion, this early study indicates a strong potential of the method even though no 'true' tumour volume was available for validation.
authors.affiliation: Department of Radiation Sciences, Umeå University, Umeå, Sweden. ida.haggstrom@radfys.umu.se
authors.forename: I
authors.initials: I
authors.lastname: Häggström
authors.forename: L
authors.initials: L
authors.lastname: Johansson
authors.forename: A
authors.initials: A
authors.lastname: Larsson
authors.forename: N
authors.initials: N
authors.lastname: Ostlund
authors.forename: J
authors.initials: J
authors.lastname: Sörensen
authors.forename: M
authors.initials: M
authors.lastname: Karlsson
mesh_terms: D000085:Acetates / Q000493:pharmacokinetics*; D000465:Algorithms; D002244:Carbon / Q000493:pharmacokinetics*; D003198:Computer Simulation; D005240:Feasibility Studies; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007700:Kinetics; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D010363:Pattern Recognition, Automated / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D000085:Acetates; D019275:Radiopharmaceuticals; C438206:carbon-11 acetate; D002244:Carbon