[Effect of a high saturated fatty acids load on serum concentrations of C-reactive protein, alpha1-antitrypsin, fibrinogen and alpha1-acid glycoprotein in obese women].
Obesity is associated with increased inflammation. Creactive protein (CRP) and inflammation-sensitive plasma protein (ISPs) are inflammatory markers. Proinflammatory process may be influenced by high saturated fatty acid intake.


OBJECTIVE
The aim of the present study was to evaluate the role of saturated fatty acids load on postprandial circulating levels of PCR and ISPs (alpha1-antitrypsin, alpha1-acid glucoprotein, and fibrinogen) in obese women.


METHODS
A total of 15 obese women (age = 31,7 +/- 4,5 years, BMI = 37,9 +/- 7,3 kg/m(2)) and 15 lean controls women (age = 30,6 +/- 4,6 years, BMI = 20,6 +/- 2,6 kg/m(2)) were recruited for this study. After and overnight fast subjects ate the fat load consisted of 75 g of fat (100% saturated fatty acid, 0% cholesterol), 5 g of carbohydrates, and 6 g of protein per m2 body surface area. Postprandial serum levels of CRP, alpha1-antitrypsin, alpha1-acid glucoprotein, and fibrinogen were measured. Anthropometry and blood biochemical parameters were measured in both groups.


RESULTS
The obese women had fasting serum PCR levels higher (p = 0,013) and fibrinogen (p = 0,04) than those of control women. Serum CRP and fibrinogen levels was positively related to body mass index (BMI) in obese group. There weren't differences in fasting serum alpha1- antitrypsin levels (p = 0,40), and alpha1-acid glucoprotein (p = 0,28) levels in obese group in comparison to lean control group. Serum CRP, alpha1-antitrypsin, alpha1-acid glucoprotein, and fibrinogen did not change postprandially (p = > 0,05 difference to fasting levels).


CONCLUSIONS
A high-saturated fatty acids load is not associated with serum CRP, alpha1-antitrypsin, alpha1-acid glucoprotein, and fibrinogen levels increase. Serum alpha1-antitripsin and alpha1-acid glucoprotein levels are not increased in obese women. Serum PCR and fibrinogen levels are increased in obese women, and are positively related to BMI.
Ramírez Alvarado
María Matilde
MM
Departamento de Bioquímica, Escuela de Ciencias Biomédicas y Tecnológicas, Facultad de Ciencias de la Salud, Universidad de Carabobo, Valencia, Carabobo, Venezuela. mmramirez@uc.edu.ve
Sánchez Roitz
C
C
Pérez Díaz
A
A
Millán Brito
E
E
D000328:Adult; D015415:Biomarkers / Q000097:blood; D001835:Body Weight / Q000502:physiology; D002097:C-Reactive Protein / Q000378:metabolism*; D005227:Fatty Acids / Q000494:pharmacology*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000097:blood; D009765:Obesity / Q000378:metabolism*; D009961:Orosomucoid / Q000378:metabolism*; D000515:alpha 1-Antitrypsin / Q000097:blood*
D015415:Biomarkers; D005227:Fatty Acids; D009961:Orosomucoid; D000515:alpha 1-Antitrypsin; D005340:Fibrinogen; D002097:C-Reactive Protein