Cutaneous presentation of plasmablastic post-transplant lymphoproliferative disorder in a 14-month-old.
We present a 14-month-old female child who developed multiple erythematous nodules on her abdomen 5 months after liver and small bowel transplantation. Skin biopsy revealed a dense infiltrate of large cells in the dermal and subcutaneous layers with frequent mitotic figures. The cells were noted to have abundant cytoplasm, prominent nucleoli, and open chromatin. Immunohistochemical stains were positive for CD138, CD56, Ki67 (>90%), and lambda chain restriction. Rare mature B cells (CD20) and rare T cells (CD3) were noted. She was diagnosed with high-grade post-transplant lymphoproliferative disorder most consistent with plasmablastic lymphoma.
Hernandez
Claudia
C
Department of Dermatology (MC 624), University of Illinois at Chicago, Chicago, Illinois 60612, USA. claudiah@uic.edu
Cetner
Aaron S
AS
Wiley
Elizabeth L
EL
D001402:B-Lymphocytes / Q000473:pathology; D001706:Biopsy; D017809:Fatal Outcome; D005260:Female; D020139:Gastroschisis / Q000601:surgery*; D006801:Humans; D007223:Infant; D007421:Intestine, Small / Q000637:transplantation*; D016031:Liver Transplantation / Q000009:adverse effects*; D008223:Lymphoma / Q000473:pathology*; D010950:Plasma Cells / Q000473:pathology*; D011183:Postoperative Complications / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*; D013277:Stomach Volvulus / Q000601:surgery; D013601:T-Lymphocytes / Q000473:pathology