[Bioactive constituents from whole herbs of Vernonia cinerea (II)].
OBJECTIVE
To study the constituents of the whole herbs of Vernonia cinerea by bio-activity guided isolation with PC-12 model.


METHODS
The constituents were separated by column chromatography and the structures were elucidated by spectroscopic methods.


RESULTS
Ten compounds were identified to be (-)-clovane-2,9-diol (1), caryolane-1,9beta-diol (2), apigenin (3), chrysoeriol (4), luteolin (5), thermopsoside (6), luteolin-7-O-beta-D-glucoside (7), quercetin(8), apigenin-4'-O-beta-D-glucoside (9), hyperin (10), beta-amyrin aceate (11), lupeol acetate (12).


CONCLUSIONS
Compounds 1, 2, 6 and 10 were isolated from this genus for the first time.
Zhu
Huaxu
H
School of Life Sciences, Nanjing Normal University, Nanjing 210024, China.
Tang
Yuping
Y
Min
Zhida
Z
Gong
Zhunan
Z
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D016716:PC12 Cells; D051381:Rats; D035741:Vernonia / Q000737:chemistry*
D004365:Drugs, Chinese Herbal