Structural basis for K(V)7.1-KCNE(x) interactions in the I(Ks) channel complex.
The cardiac I(Ks) current is involved in action potential repolarization, where its primary function is to limit action potential prolongation during sympathetic stimulation. The I(Ks) channel is mainly composed of K(V)7.1 ion channels associated with KCNE1 auxiliary subunits. The availability of KCNE1 solution structure by nuclear magnetic resonance spectroscopy in conjunction with biochemical assays addressing K(V)7.1-KCNE1 residue interactions has provided new insights into the structural basis for K(V)7.1 modulation by KCNE1. Recent evidence further suggests that KCNE2 may associate with the K(V)7.1-KCNE1 channel complex and modulate its current amplitude. Here we review recent studies in this area and discuss potential roles for multiple KCNE(x) subunits in I(Ks) generation and modulation as well as the clinical relevance of the new information.
Lundby
Alicia
A
Danish National Research Foundation Centre for Cardiac Arrhythmia, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark. alicia.lundby@cpr.ku.dk
Tseng
Gea-Ny
GN
Schmitt
Nicole
N
D000200:Action Potentials; D006801:Humans; D015640:Ion Channel Gating / Q000235:genetics* / Q000502:physiology; D051657:KCNQ1 Potassium Channel / Q000235:genetics* / Q000502:physiology; D009682:Magnetic Resonance Spectroscopy; D009206:Myocardium; D032383:Myocytes, Cardiac / Q000502:physiology*; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000235:genetics / Q000502:physiology; D024642:Potassium Channels, Voltage-Gated / Q000235:genetics* / Q000502:physiology
C489622:KCNE1 protein, human; D051657:KCNQ1 Potassium Channel; D019269:Phosphatidylinositol 4,5-Diphosphate; D024642:Potassium Channels, Voltage-Gated