[Prognostic significance of cell proliferation, microvascular density and androgen receptor level in prostatic adenocarcinoma].
Our study was concerned with prognostic significance of immunophenotypical features of prostate adenocarcinoma such as Ki-67 proliferation, androgen receptors (AR), microvascular density (MVD) in the stroma and tumor glands. Ki-67, AR and MVD expression correlated inversely with PSA level during hormonotherapy (r=0.24-0.39) as well as tumor cell differentiation grade (r=0.23-0.25). High expression of the said markers involved reduced efficiency of hormonotherapy.
Lefterov
S I
SI
Gorelov
S I
SI
Krivolapov
Iu A
IuA
D000230:Adenocarcinoma / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D049109:Cell Proliferation; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D011237:Predictive Value of Tests; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology*; D011944:Receptors, Androgen / Q000378:metabolism*
D019394:Ki-67 Antigen; D011944:Receptors, Androgen