title: Simulation of bone tissue formation within a porous scaffold under dynamic compression.
abstract: A computational model of mechanoregulation is proposed to predict bone tissue formation stimulated mechanically by overall dynamical compression within a porous polymeric scaffold rendered by micro-CT. Dynamic compressions of 0.5-5% at 0.0025-0.025 s(-1) were simulated. A force-controlled dynamic compression was also performed by imposing a ramp of force from 1 to 70 N. The model predicts homogeneous mature bone tissue formation under strain levels of 0.5-1% at strain rates of 0.0025-0.005 s(-1). Under higher levels of strain and strain rates, the scaffold shows heterogeneous mechanical behaviour which leads to the formation of a heterogeneous tissue with a mixture of mature bone and fibrous tissue. A fibrous tissue layer was also predicted under the force-controlled dynamic compression, although the same force magnitude was found promoting only mature bone during a strain-controlled compression. The model shows that the mechanical stimulation of bone tissue formation within a porous scaffold closely depends on the loading history and on the mechanical behaviour of the scaffold at local and global scales.
authors.affiliation: Institute for Bioengineering of Catalonia, Technical University of Catalonia, Barcelona, Spain. jean-louis.milan@univmed.fr
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Milan
authors.forename: Josep A
authors.initials: JA
authors.lastname: Planell
authors.forename: Damien
authors.initials: D
authors.lastname: Lacroix
mesh_terms: D001846:Bone Development; D020342:Finite Element Analysis; D008962:Models, Theoretical; D023822:Tissue Engineering; D014057:Tomography, X-Ray Computed