Effect of baseline glomerular filtration rate on renal function following stenting for atherosclerotic renal artery stenosis.
OBJECTIVE
Percutaneous transluminal renal artery angioplasty and stenting (PTRAS) is one treatment option for atherosclerotic renal artery stenosis (ARAS). However, factors predicting the outcome remain controversial. This study investigated the effect of the baseline glomerular filtration rate (GFR) on renal function after PTRAS in patients with ARAS.


METHODS
Patients who underwent PTRAS due to significant ARAS (luminal narrowing > or = 60%) were enrolled. The patients were divided into control (n = 57; estimated GFR (eGFR) > or = 60 ml/min/1.73 m(2)) and chronic renal failure (CRF) groups (n = 53; eGFR < 60 ml/min/1.73 m(2)), according to the baseline eGFR.


RESULTS
The mean age at the time of PTRAS was 62 +/- 9 years, and the mean duration of follow-up was 50 +/- 26 months. There was a significant decrease in eGFR after PTRAS in the control group, whereas the CRF group showed no significant change in eGFR. The percentage change in eGFR was negatively correlated with the baseline eGFR (r = -0.274, p = 0.004). Multivariate linear regression revealed that only baseline eGFR predicted the change in eGFR (p = 0.032).


CONCLUSIONS
PTRAS was more effective at preserving renal function in patients with moderately impaired renal function. Thus, baseline GFR may indicate the expected renal function outcome after PTRAS.
Chang
Jae Hyun
JH
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Kim
Beom Seok
BS
Oh
Hyung Jung
HJ
Yoo
Tae-Hyun
TH
Kang
Shin-Wook
SW
Lee
Ho Yung
HY
Choi
Donghoon
D
Shim
Won-Heum
WH
Choi
Kyu Hun
KH
D050197:Atherosclerosis / Q000150:complications / Q000503:physiopathology* / Q000601:surgery*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D012078:Renal Artery Obstruction / Q000209:etiology / Q000503:physiopathology* / Q000601:surgery*; D012189:Retrospective Studies; D015607:Stents