Association of A1C levels with vitamin D status in U.S. adults: data from the National Health and Nutrition Examination Survey.
OBJECTIVE
Data relating vitamin D status with indices of glucose homeostasis as manifested by A1C in the U.S. adult population are few.


METHODS
We examined the association between serum 25 hydroxyvitamin D [25(OH)D] and A1C levels in 9,773 adults (age >or=18 years old) participating in the 2003-2006 National Health and Nutrition Examination Survey. Multivariate linear regression analyzed the association after accounting for potential confounders. RESULTS Serum 25(OH)D levels were inversely associated with A1C levels in subjects age 35-74 years (P = 0.0045) and those who did not report a history of diabetes (P = 0.0282).


CONCLUSIONS
These findings support a mechanistic link between serum vitamin D concentrations, glucose homeostasis, and the evolution of diabetes in a large segment of the U.S. adult population. Screening people with elevated A1C levels for vitamin D insufficiency should be considered.
Kositsawat
Jatupol
J
1Medical Service, GV Sonny Montgomery VA Medical Center, Jackson, Mississippi, USA. Jatupol.Kositsawat@va.gov
Freeman
Vincent L
VL
Gerber
Ben S
BS
Geraci
Stephen
S
D000328:Adult; D000367:Age Factors; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011863:Radioimmunoassay; D014481:United States; D014807:Vitamin D / Q000097:blood*
D006442:Glycated Hemoglobin; D014807:Vitamin D