title: Polymorphisms in the human apolipoprotein E receptor 2 gene in Japanese sporadic Alzheimer's disease patients.
abstract: Apolipoprotein E (apoE) polymorphism is associated with onset of Alzheimer's disease (AD). We found seven polymorphisms in apoE receptor 2 (ApoER2), an apoE-binding receptor, in Japanese sporadic AD patients, but no association of ApoER2 polymorphisms with AD. We consider that the functions of ApoER2 in the brain may be compensated for by those of other apoE-binding receptors such as VLDL receptor.
authors.affiliation: Graduate School of Human Life Science, Osaka City University, Sumiyoshi, Osaka, Japan.
authors.forename: Akemi
authors.initials: A
authors.lastname: Hosoda
authors.forename: Takashi
authors.initials: T
authors.lastname: Inoue
authors.forename: Chang C
authors.initials: CC
authors.lastname: Mao
authors.forename: Young-Hee
authors.initials: YH
authors.lastname: Jeong
authors.forename: Azumi
authors.initials: A
authors.lastname: Yamagishi
authors.forename: Mingjuan
authors.initials: M
authors.lastname: Ye
authors.forename: Tokuo
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Dong-Ho
authors.initials: DH
authors.lastname: Kim
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saeki
mesh_terms: D017668:Age of Onset; D000544:Alzheimer Disease / Q000235:genetics*; D044466:Asian People; D001921:Brain / Q000378:metabolism; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D005091:Exons; D020022:Genetic Predisposition to Disease; D006801:Humans; D007438:Introns; D026502:LDL-Receptor Related Proteins; D011110:Polymorphism, Genetic; D011973:Receptors, LDL / Q000502:physiology; D018110:Receptors, Lipoprotein / Q000235:genetics*
chemical_list: D026502:LDL-Receptor Related Proteins; D011973:Receptors, LDL; D018110:Receptors, Lipoprotein; C036053:VLDL receptor; C098773:low density lipoprotein receptor-related protein 8