title: ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity.
abstract: ApoE mimetic peptide possesses the putative receptor binding domain 141-150 (LRKLRKRLLR) of apoE covalently linked to the class A amphipathic helical peptide 18A. It dramatically reduces plasma cholesterol in dyslipidemic mouse and rabbit models. Recycling of apoE mimetic peptide increases the duration of preβ-HDL formation leading to extended anti-inflammatory and atheroprotective properties.
authors.affiliation: Departments of Medicine, Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA. gdatta@uab.edu
authors.forename: Geeta
authors.initials: G
authors.lastname: Datta
authors.forename: Manjula
authors.initials: M
authors.lastname: Chaddha
authors.forename: Shaila P
authors.initials: SP
authors.lastname: Handattu
authors.forename: Mayakonda N
authors.initials: MN
authors.lastname: Palgunachari
authors.forename: Gaurav
authors.initials: G
authors.lastname: Nayyar
authors.forename: David W
authors.initials: DW
authors.lastname: Garber
authors.forename: Himanshu
authors.initials: H
authors.lastname: Gupta
authors.forename: C Roger
authors.initials: CR
authors.lastname: White
authors.forename: G M
authors.initials: GM
authors.lastname: Anantharamaiah
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001057:Apolipoproteins E / Q000737:chemistry*; D043303:Aryldialkylphosphatase / Q000737:chemistry*; D050197:Atherosclerosis / Q000517:prevention & control; D002460:Cell Line; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D008075:Lipoproteins, HDL / Q000737:chemistry*; D051379:Mice; D010455:Peptides / Q000737:chemistry; D011817:Rabbits; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D001057:Apolipoproteins E; D008055:Lipids; D008075:Lipoproteins, HDL; D010455:Peptides; D006861:Hydrogen Peroxide; D043303:Aryldialkylphosphatase