Two new chalcones from leaves of Morus alba L.
Two new chalcone derivatives named morachalcones B and C (1 and 2) were isolated from the leaves of Morus alba L. Their structures were elucidated by spectroscopic analysis. Morachalcones B (1) and C (2) represent two examples of chalcones having unusual furan rings which are formed by cyclization between C-alpha-OH and C-2-OH. Compounds 1 and 2 displayed only moderate cytotoxic activity against HCT-8 and BGC823 human cancer cell lines.
Yang
Yan
Y
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Zhang
Ting
T
Xiao
Lei
L
Yang
Lixin
L
Chen
Ruoyun
R
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D031625:Morus / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D047188:Chalcones; C553697:morachalcone B; C553698:morachalcone C