Experience of trauma and conversion to psychosis in an ultra-high-risk (prodromal) group.
OBJECTIVE
We aimed to replicate a recent finding of high prevalence of trauma history in patients at 'ultra-high risk' (UHR) of psychotic disorder and to investigate whether trauma predicts conversion to psychosis in this population.


METHODS
A consecutive sample of UHR patients was assessed. History of trauma was accessed with the General Trauma Questionnaire. Cox regression models were used to explore relationship between conversion to psychosis and trauma.


RESULTS
Of 92 UHR patients nearly 70% had experienced a traumatic event and 21.7% developed psychosis during follow-up (mean 615 days). Patients who had experienced a sexual trauma (36%) were significantly more likely to convert to first-episode psychosis (OR 2.96) after controlling for meeting multiple UHR intake groups.


CONCLUSIONS
UHR patients have a high prevalence of history of trauma. Previous sexual trauma may be a predictor of onset of psychotic disorder in this population.
Bechdolf
A
A
Department of Psychiatry, University of Melbourne, Australia. andreas.bechdolf@uk-koeln.de <andreas.bechdolf@uk-koeln.de>
Thompson
A
A
Nelson
B
B
Cotton
S
S
Simmons
M B
MB
Amminger
G P
GP
Leicester
S
S
Francey
S M
SM
McNab
C
C
Krstev
H
H
Sidis
A
A
McGorry
P D
PD
Yung
A R
AR
D000293:Adolescent; D019090:Case Management; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008016:Life Change Events; D008297:Male; D016017:Odds Ratio; D010348:Patient Care Team; D011618:Psychotic Disorders / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology* / Q000628:therapy; D012307:Risk Factors; D012569:Schizotypal Personality Disorder / Q000453:epidemiology* / Q000235:genetics / Q000523:psychology* / Q000628:therapy; D013313:Stress Disorders, Post-Traumatic / Q000453:epidemiology* / Q000523:psychology*; D014739:Victoria; D055815:Young Adult