title: Redirecting the immune response: role of adoptive T cell therapy.
abstract: Adoptive T cell therapy is aimed at overcoming constraints of the endogenous immune response. In patients with malignancies, this approach is based on the possibility of administering sufficient numbers of tumor-reactive lymphocytes under conditions in which they will promote a therapeutic response. Although this strategy is potentially applicable to a vast number of malignancies, its efficacy, to date, has been limited. This is likely related to several factors including an insufficient persistence and reactivation of infused cells, insufficient tumor infiltration, and the presence of an immunosuppressive environment. Here, we review the importance of pretransplantation host conditioning and posttransplantation strategies that have been shown to contribute to the therapeutic efficacy of infused T lymphocytes.
authors.affiliation: Division of Immunology, Transplantation, and Infectious Diseases, San Raffaele Scientific Institute, 20132 Milan, Italy. mondino.anna@hsr.it
authors.forename: Anna
authors.initials: A
authors.lastname: Mondino
authors.forename: Valérie
authors.initials: V
authors.lastname: Dardalhon
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Hess Michelini
authors.forename: Severine
authors.initials: S
authors.lastname: Loisel-Meyer
authors.forename: Naomi
authors.initials: N
authors.lastname: Taylor
mesh_terms: D000818:Animals; D064987:Cell- and Tissue-Based Therapy; D006801:Humans; D055633:Immune System Phenomena; D008214:Lymphocytes / Q000276:immunology; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology*