title: [Epidemiologic study on patients with invasive fungal infections].
abstract: OBJECTIVE
  To investigate the epidemiological features of patients with nosocomial invasive fungal infection.
  
  
  METHODS
  Fungi in blood were identified by BacT ALERT 3D, other clinical samples were cultured by Sabouraud's dextrose agar (SDA) medium. Candidas were isolated and identified by CHRO Magar candida color medium. Fungus-cultured positive cases from Jan. 2004 to Nov. 2007 were analyzed on items as patients' age, underlying disease, sample, strain, and species distribution. All statistical analyses were carried out by SPSS 13.0.
  
  
  RESULTS
  The overall incidence rate of invasive fungal infections was 4.12%. The average age of patients was 7 - 96 with most patients were male, with geriatric problems and different kinds of underlying diseases. Lower respiratory tract infection was the most frequent infection site, followed by urinary tract, gastrointestinal tract. The main pathogens of invasive fungal infections were Candidas (93.80%). Strains of Candida albicans were the most frequent organisms which accounted for 67.29% of all the isolates. Mould fungus infections accounted for only 6.20%. During the 4 years of observation, the detection rate of fungi, specimen sources and the distribution of species and compartment were different with significant differences (P < 0.0083).
  
  
  CONCLUSIONS
  The epidemiological properties such as the source of specimen, the distribution of species and composition sections of invasive fungal infections were changing. Candida spp. were still the main pathogens of invasive fungal infections but the sections of fungi changed. The incidence of Aspergillus infections had been increasing recently.
authors.affiliation: Department of Dermatovenereology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Wen-li
authors.initials: WL
authors.lastname: Feng
authors.forename: Jing
authors.initials: J
authors.lastname: Yang
authors.forename: Zhi-qin
authors.initials: ZQ
authors.lastname: Xi
authors.forename: Yan-qing
authors.initials: YQ
authors.lastname: Wang
authors.forename: Run-mei
authors.initials: RM
authors.lastname: Zhang
authors.forename: Ying
authors.initials: Y
authors.lastname: Ji
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wu
authors.forename: Xiao-qiang
authors.initials: XQ
authors.lastname: Jia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002175:Candida / Q000302:isolation & purification; D002648:Child; D002681:China / Q000453:epidemiology; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D041981:Gastrointestinal Tract / Q000382:microbiology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000453:epidemiology* / Q000382:microbiology; D012141:Respiratory Tract Infections / Q000382:microbiology; D012737:Sex Factors; D014552:Urinary Tract Infections / Q000382:microbiology; D055815:Young Adult