Quinine-resistant malaria in traveler returning from Senegal, 2007.
We describe clinical and parasitologic features of in vivo and in vitro Plasmodium falciparum resistance to quinine in a nonimmune traveler who returned to France from Senegal in 2007 with severe imported malaria. Clinical quinine failure was associated with a 50% inhibitory concentration of 829 nmol/L. Increased vigilance is required during treatment follow-up.
Pradines
Bruno
B
Institut de Medecine Tropicale du Service de Sante des Armees, Marseille, France.
Pistone
Thierry
T
Ezzedine
Khaled
K
Briolant
Sebastien
S
Bertaux
Lionel
L
Receveur
Marie Catherine
MC
Parzy
Daniel
D
Millet
Pascal
P
Rogier
Christophe
C
Malvy
Denis
D
D000293:Adolescent; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology*; D004351:Drug Resistance; D005602:France; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology; D008297:Male; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D011803:Quinine / Q000008:administration & dosage / Q000494:pharmacology*; D012675:Senegal; D014195:Travel
D000962:Antimalarials; D011803:Quinine