Secondary heterologous dengue infection risk: Disequilibrium between immune regulation and inflammation?
Increased serum levels of cytokines released by cells of the immune response have been detected in patients suffering from dengue disease. Likewise, secondary infections by a different dengue virus serotype result in a highest risk of development of the severe dengue disease. Both findings suggest that the memory immune response is one of the key players in the pathogenesis of this disease. Here we take advantage of the particular Cuban epidemiological situation in dengue to analyze a broad spectrum of cell-mediated immune response mediators at mRNA and protein level. Evidences for a regulatory immune pattern in homologous (TGF-beta, IL-10) vs. pro-inflammatory pattern (IFN-gamma, TNF-alpha) in heterologous dengue virus re-challenge were found, suggesting a possible association with the higher incidence of severe dengue cases in the latter case.
Sierra
Beatriz
B
Cellular Immunology Lab, Virology Department, PAHO/WHO Collaborating Center for the Study of Dengue and its Vector, Institute of Tropical Medicine, Pedro Kouri Autopista Novia del Mediodia, La Lisa, Ciudad Habana, Cuba. siebet@ipk.sld.cu
Perez
Ana B
AB
Vogt
Katrin
K
Garcia
Gissel
G
Schmolke
Kathrin
K
Aguirre
Eglys
E
Alvarez
Mayling
M
Kern
Florian
F
Kourí
Gustavo
G
Volk
Hans-Dieter
HD
Guzman
Maria G
MG
D000328:Adult; D003462:Cuba / Q000453:epidemiology; D016207:Cytokines / Q000097:blood / Q000276:immunology; D003715:Dengue / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D003716:Dengue Virus / Q000276:immunology; D005260:Female; D006801:Humans; D007107:Immune System / Q000276:immunology; D007156:Immunologic Memory / Q000276:immunology*; D007249:Inflammation / Q000097:blood / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult
D016207:Cytokines