Estimating GFR in children with 99mTc-DTPA renography: a comparison with single-sample 51Cr-EDTA clearance.
Glomerular filtration rate (GFR) measurement by (51)Cr-ethylenediaminetetraacetic acid (EDTA) and blood sampling in children is usually cumbersome for the patient, parents and laboratory technicians. We have previously developed a method accurately estimating GFR in adults. The aim of the present study was to evaluate the accuracy of this non-invasive method in children. We calculated GFR from (99m)Tc-diethylene triamine pentaacetic acid (DTPA) renography and compared with (51)Cr-EDTA plasma clearance of 29 children between the age of 1 month and 12 years (mean 4.7 years). The correlation between (99m)Tc-DTPA renography and (51)Cr-EDTA plasma clearance was for all children R = 0.96 (n = 29, P<0.0001), for children above 2 years of age R = 0.96 (n = 18, P<0.0001) and for children <2 years R = 0.84 (n = 11, P<0.001). We conclude that assessment of GFR from (99m)Tc-DTPA renography is reliable and comparable to GFR calculated from (51)Cr-EDTA plasma clearance. Because our method is non-invasive and only takes 21 min, it may be preferable in many cases where an assessment of renal function is needed in children especially when renography is performed anyhow.
Gutte
Henrik
H
Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Rigshospitalet, Denmark. henrik.gutte@rh.regionh.dk
Møller
Michael L
ML
Pfeifer
Andreas K
AK
Thorup
Jørgen
J
Borgwardt
Line
L
Borgwardt
Lise
L
Kristoffersen
Ulrik S
US
Kjaer
Andreas
A
D002648:Child; D002675:Child, Preschool; D002860:Chromium Radioisotopes / Q000493:pharmacokinetics; D004492:Edetic Acid / Q000493:pharmacokinetics*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism*; D007674:Kidney Diseases / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D011866:Radioisotope Renography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016284:Technetium Tc 99m Pentetate / Q000493:pharmacokinetics*
D002860:Chromium Radioisotopes; D019275:Radiopharmaceuticals; D004492:Edetic Acid; D016284:Technetium Tc 99m Pentetate