title: [Predictors of changes in drug regimens for treating AIDS in children].
abstract: To identify the causes of changes in therapeutic regimens for treating AIDS in children infected through vertical transmission. This was a case-control study in which the control group consisted of 49 children who had not had any changes to their antiretroviral regimen and the case group consisted of 62 children who had had changes between January 2000 and December 2005. Data from the patients' medical files and a semistructured interview were used. The data analysis was carried out using the SPSS software, and the chi-square test and logistic regression were applied. The main causes of changes in treatment were: increased viral load (48.4%), poor immunological response (46.6%) and clinical worsening (35.5%) of the patients. The adjustment of the data through logistic regression analysis showed that drug intolerance was the variable that contributed most to the change in medication ((adjusted) OR: 79.94; 95% CI: 6.28 -1034.55). Adherence was not shown to be responsible for changes in the anti-retroviral therapy, and this was attributable to the organization of the service and actions of the interdisciplinary team.
authors.affiliation: Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória, Vitória, ES. cristinarmacedo@gmail.com
authors.forename: Cristina Ribeiro
authors.initials: CR
authors.lastname: Macedo
authors.forename: Diana de Oliveira
authors.initials: Dde O
authors.lastname: Frauches
authors.forename: Laylla Ribeiro
authors.initials: LR
authors.lastname: Macedo
authors.forename: Sandra Fagundes
authors.initials: SF
authors.lastname: Moreira-Silva
authors.forename: Priscila Rocha de Araújo
authors.initials: PR
authors.lastname: Nader
authors.forename: Ana Paula Neves Burian
authors.initials: AP
authors.lastname: Lima
authors.forename: Ethel Leonor Nóia
authors.initials: EL
authors.lastname: Maciel
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000635:transmission; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D012044:Regression Analysis
chemical_list: D019380:Anti-HIV Agents