The influence of other than prolactin hormones on bone mineral density in women with hyperprolactinaemia of various origins.
OBJECTIVE
Hyperprolactinaemia may lead to bone loss, both due to hypogonadism and other hormonal disturbances. Aim of the case-control study was the analysis of influences of hormonal profiles associated with hyperprolactinaemia on the bone mineral density (BMD) in women with hyperprolactinaemia of various origin.


METHODS
The subjects were 32 patients with prolactinoma, 43 ones with functional hyperprolactinaemia and 29 healthy controls. All of them were studied for BMD (lumbar spine, proximal femur, forearm, total body) by dual-energy X-ray absorptiometry and their correlations with hormones levels (prolactin, oestradiol, luteinising hormone, follicle stimulating hormone, sex hormone binding globulin (SHBG), testosterone, dehydroepiandrosterone sulphate (DHEA-S), insulin-like growth factor-1 and intact parathyroid hormone) using Spearman correlation analysis and multiple regression analysis model.


RESULTS
Correlation analysis revealed the anabolic influence of PTH on lumbar spine in women with prolactinoma, and on ultradistal radius in functional hyperprolactinaemia. In multiple regression analysis, oestradiol had greatest influence on lumbar spine and total body BMD. Moreover, positive influence of testosterone, SHBG on spine BMD, and of oestradiol, testosterone, SHBG and DHEA-S on total body BMD were observed in patients with prolactinoma.


CONCLUSIONS
Hormonal disturbances associated with hyperprolactinaemia influence BMD more in patients with prolactinoma than in ones with functional hyperprolactinaemia.
Bolanowski
Marek
M
Department of Endocrinology, Diabetology and Isotope Therapy, Medical University, Wroclaw, Poland. bolan@endo.am.wroc.pl
Zadrozna-Sliwka
Beata
B
Jawiarczyk
Aleksandra
A
Syrycka
Joanna
J
D000328:Adult; D015519:Bone Density; D016022:Case-Control Studies; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000209:etiology / Q000503:physiopathology*; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D015175:Prolactinoma / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D055815:Young Adult
D006728:Hormones