title: Effect of transient forebrain ischemia on flavoprotein autofluorescence and the somatosensory evoked potential in the rat.
abstract: In order to evaluate the effect of cerebral ischemia on the flavoprotein fluorescence (FPF), we compared the changes in the FPF and somatosensory evoked potential (SEP) during transient cerebral ischemia in the rat. We measured the FPF and SEP simultaneously via a cranial window made over the right sensorimotor cortex during the left median nerve stimulation in F344 rats. We compared change in FPF and SEP during cerebral ischemia for 60 min. The rCBF were rapidly recovered after reperfusion. However, the recovery rates of the FPF were significantly faster than those of the SEP after reperfusion. These findings indicate that activity-dependent changes of the FPF do not necessarily correlate with the electrical activity after transient cerebral ischemia.
authors.affiliation: Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, Tokyo 173-8610, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Igarashi
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sakatani
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Hoshino
authors.forename: Norio
authors.initials: N
authors.lastname: Fujiwara
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Murata
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Kano
authors.forename: Jun
authors.initials: J
authors.lastname: Kojima
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Katayama
mesh_terms: D000818:Animals; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005420:Flavoproteins / Q000378:metabolism*; D005453:Fluorescence; D002546:Ischemic Attack, Transient / Q000150:complications / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D015427:Reperfusion Injury / Q000150:complications / Q000503:physiopathology
chemical_list: D005420:Flavoproteins