Selective MMP13 inhibitors.
Pharmacology of MMP13 and MMP13 selective inhibitors is reviewed.
Li
Jie Jack
JJ
Discovery Chemistry, Bristol-Myers Squibb Company, Wallingford, Connecticut 06492, USA. jack.li@bms.com
Johnson
Adam R
AR
D000495:Allosteric Site; D000818:Animals; D002356:Cartilage / Q000378:metabolism; D003094:Collagen / Q000737:chemistry; D015195:Drug Design; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D007249:Inflammation; D007700:Kinetics; D061965:Matrix Metalloproteinase Inhibitors; D051379:Mice; D018345:Mice, Knockout; D010003:Osteoarthritis / Q000188:drug therapy*; D011480:Protease Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D003094:Collagen