The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis.
OBJECTIVE
The objective of the study was to determine whether single-nucleotide polymorphisms (SNPs) that influence the maternal innate immune response are associated with puerperal group A streptococcal sepsis.


METHODS
Subjects with confirmed puerperal group A streptococal infection were prospectively identified in 2 tertiary care hospitals over 18 years. Controls were racially matched subjects with term, uncomplicated deliveries. Thirty-eight polymorphisms associated with the innate immune response to bacterial infection were analyzed. Allele and genotype frequencies for subjects and controls were compared.


RESULTS
Forty-eight women with puerperal group A streptococcal infection were identified. DNA was obtained for 28 subjects and 54 controls. Allele frequencies were significantly different between subjects and controls for polymorphisms in Toll-like receptor (TLR) 9-1486 (P = .03) and heat shock protein (HSP) 70-2 1267 (P = .003). Genotype frequencies were significantly different between subjects and controls for TLR9-1486 (P = .025), HSP70-2 1267 (P = .02), and interleukin (IL)-1beta-511 (P = .016).


CONCLUSIONS
Puerperal group A streptococcal sepsis may be associated with innate immune response gene polymorphisms in TLR9, HSP70-2, and IL1beta.
Davis
Sarah M
SM
Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, USA.
Clark
Erin A S
EA
Nelson
Lesa T
LT
Silver
Robert M
RM
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D007113:Immunity, Innate; D053583:Interleukin-1beta / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D011644:Puerperal Disorders / Q000382:microbiology; D018805:Sepsis / Q000235:genetics* / Q000382:microbiology; D013290:Streptococcal Infections / Q000235:genetics; D013297:Streptococcus pyogenes; D051217:Toll-Like Receptor 9 / Q000235:genetics*
D018840:HSP70 Heat-Shock Proteins; D053583:Interleukin-1beta; D051217:Toll-Like Receptor 9