title: [Polyketide antibiotics produced by polyketide synthase in streptomyces--a review].
abstract: Polyketides have played an important role in antibiotic drug discovery with most antibacterial drugs being derived from a natural product or natural product lead. Furthermore, the biosynthetic gene clusters for numerous bioactive polyketides have been intensively studied over the past 15 years. This paper focuses on the polyketide drugs approved by US-FDA and takes a general view in the antibiotics produced by polyketide synthase in streptomyces.
authors.affiliation: South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China. cmj-v@163.com
authors.forename: Minjie
authors.initials: M
authors.lastname: Chen
authors.forename: Guanghua
authors.initials: G
authors.lastname: Wang
authors.forename: Shikun
authors.initials: S
authors.lastname: Dai
authors.forename: Lianwu
authors.initials: L
authors.lastname: Xie
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D008969:Molecular Sequence Data; D048630:Polyketide Synthases / Q000235:genetics / Q000378:metabolism*; D013302:Streptomyces / Q000737:chemistry / Q000201:enzymology / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D018942:Macrolides; D048630:Polyketide Synthases