Diversity of protein structures and difficulties in fold recognition: the curious case of protein G.
We examine the ability of current state-of-the-art methods in protein structure prediction to discriminate topologically distant folds encoded by highly similar (>90% sequence identity) designed proteins in blind protein structure prediction experiments. We detail the corresponding prognosis for the protein fold recognition field and highlight the features of the methodologies that successfully deciphered this folding riddle.
Horst
Jeremy
J
Samudrala
Ram
R