The role of visfatin in the pathogenesis of gestational diabetes mellitus.
OBJECTIVE
The objective of the present study was to evaluate the role of visfatin in gestational diabetes mellitus.


METHODS
Forty-five pregnant women at 24 to 28 weeks' gestation were assigned to consume an initial screening test using a 1-h 50-g glucose load, and then a 3-h 100-g glucose load. The study group consisted of 23 patients who were diagnosed with gestational diabetes mellitus and the control group consisted of 22 healthy pregnant women. We studied the levels of visfatin and the other parameters of inflammation, glucose and lipid metabolism between the 24th and 28th week of gestation and also between the 6th and 10th week after delivery.


RESULTS
Plasma visfatin and glucose levels at 60 min after a 50-g and a 100-g glucose load between the 24th and 28th week of gestation were significantly higher in the gestational diabetes group than in the control group. There were no statistical differences in visfatin levels between the groups at 6-10 weeks post-partum.


CONCLUSIONS
Visfatin levels were significantly elevated in women with gestational diabetes mellitus and during the course of pregnancy and increased visfatin concentrations were reduced within 6 to 10 weeks after delivery.
Gok
D E
DE
Department of Endocrinology, Gulhane Military Medicine Faculty, Etlik, Kecioren, 0640 Ankara, Turkey. dengingok@yahoo.com
Yazici
M
M
Uckaya
G
G
Bolu
S E
SE
Basaran
Y
Y
Ozgurtas
T
T
Kilic
S
S
Kutlu
M
M
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood / Q000502:physiology*; D036861:Delivery, Obstetric; D016640:Diabetes, Gestational / Q000097:blood / Q000209:etiology*; D005260:Female; D005865:Gestational Age; D005951:Glucose Tolerance Test; D006801:Humans; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood / Q000502:physiology*; D049590:Postpartum Period / Q000097:blood; D011247:Pregnancy
D001786:Blood Glucose; D016207:Cytokines; D054409:Nicotinamide Phosphoribosyltransferase; C085455:nicotinamide phosphoribosyltransferase, human