title: Extensively drug resistant tuberculosis (XDR-TB) in Chest Disease Institute, 1997-2005.
abstract: OBJECTIVE
  To determine prevalence of extensively drug resistant tuberculosis (XDR-TB) in Chest Disease Institute. World Health Organization has given the definition of XDR-TB as multi-drug resistant tuberculosis which also resists fluoroquinolone and aminoglycoside.
  
  
  METHODS
  The present study was a retrospective review and conducted at Microbiology Unit, Chest Disease Institute. Drug susceptibility testing against fluoroquinolone and aminoglycoside have been done routinely since 1997. Laboratory results were studied to find XDR-TB patients and medical record information were reviewed. Laboratory results in 2006-2007 were not completed so were not included in the review.
  
  
  RESULTS
  The result of the present study showed that from 1997 to 2005. 10,289 patients were tested for drug susceptibility. XDR-TB was found in 39 patients. Prevalence of XDR-TB was 6, 6, 9, 4, 3, 3, 2, 4 and 2 patients from 1997-2005 respectively. Most of XDR-TB patients were also resistant to Streptomycin and 39% resistant to Ethambutol. No data of resistance to second line drugs of XDR-TB was done in the present study.
  
  
  CONCLUSIONS
  The present study confirmed the existing of XDR-TB in Thai patient for a long time but not in increasing rate. The authorized TB Control organization should take XDR-TB as an important problem and developed capacity of tuberculosis laboratory in order to be able to diagnose XDR-TB.
authors.affiliation: Division of Respiratory Medicine, Chest Disease Institute, Ministry of Public Health, Nonthaburi, Thailand.
authors.forename: Charoen
authors.initials: C
authors.lastname: Chuchottaworn
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D054908:Extensively Drug-Resistant Tuberculosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D012189:Retrospective Studies; D013785:Thailand / Q000453:epidemiology
chemical_list: D000995:Antitubercular Agents