Stanozolol treatment for successful prevention of attacks of severe primary cryofibrinogenemia.
Severe essential cryofibrinogenemia is rare in childhood, and both the diagnosis and the management are challenging for pediatricians. An 11-year-old male, who had already lost two digits following cold exposure, was referred after multiple visits to various hospitals and subsequently diagnosed as primary cryofibrinogenemia. His history revealed unresponsiveness to calcium channel blockers, acetyl salicylic acid, pentoxifylline, dextran, and steroids. Stanozolol (2 mg/day, orally) prophylaxis was initiated and no new skin lesions developed following starting this treatment. Some of the newly formed lesions at the onset of stanozolol healed.
Unal
Sule
S
Faculty of Medicine, Department of Pediatrics, Division of Pediatric Hematology, Hacettepe University, Ankara, Turkey. suleunal@hacettepe.edu.tr
Kara
Fehime
F
Ozen
Seza
S
Orhan
Diclehan
D
Tuncer
Murat
M
Gumruk
Fatma
F
D000284:Administration, Oral; D002648:Child; D003449:Cryoglobulinemia / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control*; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D013197:Stanozolol / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome
D013197:Stanozolol