[In vitro susceptibility of staphylococci to ciprofloxacin].
OBJECTIVE
To evaluate the in vitro activity of ciprofloxacin against communitary and hospital staphylococcal strains isolated during 2006-2008 in Eastern region of Romania.


METHODS
We have tested 1022 staphylococci strains, identified by conventional laboratory methods. Minimum inhibitory concentrations (MICs) were determined by agar dilution method, according to NCCLS.


RESULTS
For both hospital and communitary isolates, MIC 90 was 0.25 mg/L (4 fold less than breakpoint for sensitivity). Resistance was absent or reduced (1.7%) for coagulase- positive staphylococci, both communitary and hospital. For coagulase negative staphylococci, resistance for clinical strains is increased (6%) compared to comunitary strains (0.3%). In conclusion, ciprofloxacin is highly effective against staphylococci representing a therapeutic option for multiresistant strains. Our data shown the necessity of adequate antibiotic use in the hospital and community.
Tuchiluş
Cristina
C
Facultatea de Farmacie, Disciplina de Microbiologie, Universitatea de Medicină si Farmacie "Gr.T. Popa" Iaşi.
Poiată
Antonia
A
Buiuc
D
D
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D017714:Community-Acquired Infections / Q000382:microbiology; D003428:Cross Infection / Q000382:microbiology; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000382:microbiology*; D013210:Staphylococcus / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D002939:Ciprofloxacin