Non-alpha-hydroxylated aldehydes with evolved transketolase enzymes.
Transketolase mutants previously identified for use with the non-phosphorylated aldehyde propanal have been explored with a series of linear and cyclic aliphatic aldehydes, and excellent stereoselectivities observed.
Cázares
Armando
A
Department of Chemistry, University College London, 20 Gordon Street, London, UK WC1H 0AJ.
Galman
James L
JL
Crago
Lydia G
LG
Smith
Mark E B
ME
Strafford
John
J
Ríos-Solís
Leonardo
L
Lye
Gary J
GJ
Dalby
Paul A
PA
Hailes
Helen C
HC
D000447:Aldehydes / Q000737:chemistry* / Q000378:metabolism*; D020134:Catalytic Domain; D004926:Escherichia coli / Q000201:enzymology; D006900:Hydroxylation; D008958:Models, Molecular; D017354:Point Mutation; D013237:Stereoisomerism; D013379:Substrate Specificity; D014174:Transketolase / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*
D000447:Aldehydes; D014174:Transketolase