title: A novel polymethylmethacrylate hydrophilic adhesive matrix intended for transdermal patch formulations.
abstract: A novel poly(sodium methacrylate, methylmethacrylate) hydrophilic pressure sensitive adhesive (PSA) containing a large amount of water was designed. The effects of PEG400, glycerin, sorbitol, and/or NaCl on the in vitro and in vivo adhesive properties were investigated by means of a 2(4) full factorial design. The optimized formulation, containing all independent variables at the highest value, was loaded with lidocaine hydrochloride (LH). This formulation permitted to obtain a 4-fold higher LH flux through human skin with respect to the marketed products.
authors.affiliation: Department of Pharmaceutical Sciences 'Pietro Pratesi', Università degli Studi di Milano, via G. Colombo, 71-20133 Milan, Italy. francesco.cilurzo@unimi.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Cilurzo
authors.forename: Paola
authors.initials: P
authors.lastname: Minghetti
authors.forename: Chiara G M
authors.initials: CG
authors.lastname: Gennari
authors.forename: Antonella
authors.initials: A
authors.lastname: Casiraghi
authors.forename: Luisa
authors.initials: L
authors.lastname: Montanari
mesh_terms: D000268:Adhesiveness; D000269:Adhesives; D000279:Administration, Cutaneous; D000328:Adult; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000737:chemistry; D001702:Biopharmaceutics; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D016503:Drug Delivery Systems; D004890:Erythema / Q000139:chemically induced; D005079:Excipients; D005990:Glycerol / Q000737:chemistry; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000737:chemistry; D010968:Plasticizers; D019904:Polymethyl Methacrylate / Q000009:adverse effects / Q000737:chemistry*; D012869:Skin Absorption; D012965:Sodium Chloride / Q000737:chemistry; D013012:Sorbitol / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000269:Adhesives; D000779:Anesthetics, Local; D005079:Excipients; D010968:Plasticizers; D012965:Sodium Chloride; D013012:Sorbitol; D019904:Polymethyl Methacrylate; D008012:Lidocaine; D005990:Glycerol