title: Structural asymmetries in motor and language networks in a population of healthy preterm neonates at term equivalent age: a diffusion tensor imaging and probabilistic tractography study.
abstract: In this MRI study, we aimed to provide new in vivo structural markers of asymmetry in motor and language networks in a population of healthy preterm neonates scanned at term equivalent age. Using diffusion tensor imaging and probabilistic tractography, we showed that, besides volume and microstructural asymmetries in the parieto-temporal part of the superior longitudinal fasciculus (SLF) and a trend towards microstructural asymmetry in the corticospinal tract (CST), volume asymmetry in the motor part of the superior thalamic radiations (STR) and a trend towards volume asymmetry in the CST are already present in the neonatal period. No asymmetry was found in the sensory part of the STR, the anterior thalamic radiations (ATR), and posterior thalamic radiations (PTR) neither in the fronto-parietal part of the SLF. These results suggest that structural asymmetries in the motor and language networks are present in healthy preterm neonates at term equivalent age, well before the development of speech and hand preference.
authors.affiliation: Department of Radiology, ULB-Hôpital Erasme, Brussels, Belgium. yanliu@ulb.ac.be
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Danielle
authors.initials: D
authors.lastname: Balériaux
authors.forename: Martin
authors.initials: M
authors.lastname: Kavec
authors.forename: Thierry
authors.initials: T
authors.lastname: Metens
authors.forename: Julie
authors.initials: J
authors.lastname: Absil
authors.forename: Vincent
authors.initials: V
authors.lastname: Denolin
authors.forename: Anne
authors.initials: A
authors.lastname: Pardou
authors.forename: Freddy
authors.initials: F
authors.lastname: Avni
authors.forename: Patrick
authors.initials: P
authors.lastname: Van Bogaert
authors.forename: Alec
authors.initials: A
authors.lastname: Aeby
mesh_terms: D001921:Brain / Q000002:abnormalities*; D001931:Brain Mapping / Q000379:methods*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male