Total regioselective transformation of aromatic aziridine 2-carboxamides into 2-aminoamides promoted by active manganese.
A novel, totally regioselective transformation of aromatic N-4-methoxyphenylaziridine 2-carboxamides into 2-aminoamides promoted by active manganese (Mn*) is reported. alpha-Amino ketones can be readily obtained by reaction of morpholine-derived 2-aminoamides with organolithium compounds.
Concellón
José M
JM
Departamento de Química Orgánica e Inorgánica, Facultad de Química, Universidad de Oviedo, Spain. jmcg@uniovi.es
Rodríguez-Solla
Humberto
H
Del Amo
Vicente
V
Díaz
Pamela
P
D001388:Aziridines / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007659:Ketones / Q000737:chemistry*; D018020:Lithium Compounds / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008345:Manganese / Q000737:chemistry*; D015394:Molecular Structure; D009025:Morpholines / Q000737:chemistry; D013237:Stereoisomerism
D001388:Aziridines; D007659:Ketones; D018020:Lithium Compounds; D009025:Morpholines; C518574:aziridine-2-carboxamide; D008345:Manganese; C037574:morpholine