Membrane curvature in synaptic vesicle fusion and beyond.
Recent evidence suggests that the Ca(2+)-sensors synaptotagmin-1 and Doc2b deform synaptic membranes during synaptic vesicle exocytosis. We discuss how local curvature generated by these and other proteins may stimulate membrane fusion and discuss the potential implications of these findings for other cellular fusion events.
McMahon
Harvey T
HT
MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB0 2QH, UK. hmm@mrc-lmb.cam.ac.uk
Kozlov
Michael M
MM
Martens
Sascha
S
D000818:Animals; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007425:Intracellular Membranes / Q000737:chemistry / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D059828:Plant Cells; D050600:SNARE Proteins / Q000378:metabolism; D013569:Synapses / Q000378:metabolism; D013572:Synaptic Vesicles / Q000737:chemistry / Q000378:metabolism*
D008565:Membrane Proteins; D050600:SNARE Proteins