[Effects of Rhizoma zingiberis and Pericarpium citri reticulatae extracts on myocardial ischemia in rats].
OBJECTIVE
To observe the effects of Rhizoma Zingiberis and Pericarpium Citri Reticulatae extracts on acute myocardial ischemia rats and explore the mechanism.


METHODS
The model of myocardial ischemia in rats was established by ligating the front descending anterior branch of the coronary artery. With Fufang Danshen Pill as positive control drug,the effects of Rhizoma Zingiberis and Pericarpium Citri Reticulatae extracts on the electrocardiogram (ECG), the extension of myocardial infarction, the hemorheology indexes, lactic dehydrogenase (LDH), creatine kinase (CK), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) in rats were evaluated.


RESULTS
Rhizoma Zingiberis and Pericarpium Citri Reticulatae extracts decreased the ST-segment of ECG (P < 0.01), reduced the extension of myocardial infarction (P < 0.05), decreased the contents of CK and LDH in serum (P < 0.01 or P < 0.05), improved hemorheology (P < 0.05), increased SOD and GSH-Px activity and decreased MDA content (P < 0.05).


CONCLUSIONS
Rhizoma Zingiberis and Pericarpium Citri Reticulatae extracts have protective effect on myocardial ischemia in rats, and its mechanism may be related to inhibiting lipid peroxidation.
Ou
Li-juan
LJ
College of Traditional Chinese Medicine, Guangzhou University of TCM, Guangzhou 510405, China. olj001@163.com
Sun
Xiao-ping
XP
Liu
Qi-de
QD
Mi
Sui-qing
SQ
Wang
Ning-sheng
NS
D000208:Acute Disease; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D002957:Citrus / Q000737:chemistry; D003402:Creatine Kinase / Q000097:blood; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D004562:Electrocardiography; D018056:Hemorheology / Q000187:drug effects; D045022:Lactate Dehydrogenases / Q000097:blood; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009203:Myocardial Infarction / Q000188:drug therapy / Q000473:pathology; D017202:Myocardial Ischemia / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000201:enzymology / Q000473:pathology; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D030521:Zingiberaceae / Q000737:chemistry
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; C517866:fufang danshen; D008315:Malondialdehyde; D045022:Lactate Dehydrogenases; D013482:Superoxide Dismutase; D003402:Creatine Kinase