Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent.
Aminomethylated Beaucage's reagent 1 was found to be more potent than 3H-1,2-benzodithiol-3-one 1,1-dioxide (Beaucage's reagent) in causing DNA cleavage. The current study demonstrated the importance of the amino functionality in enhancing DNA-cleaving activities, and such findings may facilitate development of novel sulfur-containing DNA-cleaving molecules in cancer therapy.
Zheng
Jiahui
J
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Republic of Singapore.
Liu
Xiaoqian
X
Yuan
Qing
Q
Shin
Yoon-Joo
YJ
Sun
Daekyu
D
Lu
Yixin
Y
D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006863:Hydrogen-Ion Concentration; D008745:Methylation; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
C414667:1,2-benzodithiol-3-one-1,1-dioxide; D013438:Sulfhydryl Compounds; D004247:DNA