[Experimental cutaneous sporotrichosis: in vivo evaluation of itraconazole and terbinafine].
The aim of this study was to evaluate the in vivo activity of itraconazole and terbinafine for treating experimental cutaneous sporotrichosis. Eighty Wistar rats were used, divided into four groups (TERB20, TERB30, ITRA and CONT). They were inoculated in the left plantar pad with 0.2 ml of solution containing 2x10(3) cell/ml of Sporothrix schenckii and treated with terbinafine (20 and 30 mg/kg), itraconazole (10 mg/kg) or placebo for 13 weeks. The lesions at the inoculation site were evaluated and measured weekly, along with their dissemination. Mycological and histopathological analyses were performed subsequently. The results showed that the animals in the ITRA group differed statistically in all parameters evaluated, in relation to CONT. For terbinafine, there were no statistical differences between the treated and control groups. It could be confirmed that itraconazole presented good activity for treating sporotrichosis, while terbinafine was ineffective for this disease at the doses used. However, more studies on the latter antifungal agent are needed.
Antunes
Tatiana de Avila
Tde A
Pós-Graduação em Veterinária, Faculdade de Veterinária, Universidade Federal de Pelotas, Pelotas, RS. tatdavila@bol.com.br
Nobre
Márcia de Oliveira
Mde O
Faria
Renata Osório de
RO
Meinerz
Ana Raquel Mano
AR
Martins
Anelise Afonso
AA
Cleff
Marlete Brum
MB
Fernandes
Cristina Gevehr
CG
Meireles
Mário Carlos Araújo
MC
D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D017964:Itraconazole / Q000627:therapeutic use*; D008297:Male; D009281:Naphthalenes / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013174:Sporotrichosis / Q000188:drug therapy* / Q000473:pathology; D000077291:Terbinafine
D000935:Antifungal Agents; D009281:Naphthalenes; D017964:Itraconazole; D000077291:Terbinafine