Blood-aqueous barrier function in a patient with choroideremia.
The purpose was to determine whether there was a breakdown of the blood-aqueous barrier in a patient with choroideremia. A 27-year-old man with typical choroideremia underwent standardized ophthalmo-logical evaluation, including quantitative measurement of aqueous flare intensity, by a laser flare-cell meter. The results showed areas of atrophy of the choriocapillaries and retinal pigment epithelium in the mid-periphery and posterior pole, although not in the macula. Fluorescein angiography showed areas of loss of the choriocapillaries and retinal pigment epithelium. The fovea was spared with a surrounding zone of hy-perfluorescence. Electroretinography showed a subnormal photopic amplitude and extinguished scotopic response. Electrooculography revealed that the light peak/dark trough ratio was reduced. Goldmann perimetry showed constricted peripheral fields. Laser photometry showed an increase in the aqueous flare intensity in both eyes, as compared with normal subjects. We conclude that the function of the blood-aqueous barrier might be affected in patients with choroideremia.
Chen
Muh-Shy
MS
Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. chenmuhshy@ntu.edu.tw
Chang
Ching-Chung
CC
Ho
Tzyy-Chang
TC
Tsai
Tzu-Hsun
TH
Fan
I-More
IM
Hou
Ping-Kang
PK
D000328:Adult; D001082:Aqueous Humor / Q000378:metabolism; D018916:Blood-Aqueous Barrier / Q000503:physiopathology*; D015794:Choroideremia / Q000378:metabolism*; D004585:Electrooculography; D004596:Electroretinography; D005451:Fluorescein Angiography; D006801:Humans; D008297:Male; D010783:Photometry; D012164:Retinal Diseases / Q000378:metabolism*; D055213:Retinal Pigment Epithelium