Cholangiocarcinoma: descriptive epidemiology and risk factors.
In theory, the term of cholangiocarcinoma is reserved for the tumours originating from the intrahepatic bile ducts. The problems of classification of the most frequent hilar tumours and the absence of histopathological confirmation in a large percentage of cases in cancer registries from many countries show the difficulty of establishing the specific epidemiologic behaviour of intrahepatic cholangiocarcinoma (ICC). There are clearly two types of ICC: the first one is the consequence of the recurrent infection of the biliary ducts by the parasites Opisthorchis viverrini and Clonorchis sinensis, and is only seen in the areas of Southeast Asia where liver flukes are endemic. In these areas, incidence and mortality rates of ICC are extremely high. Both parasites have been classified class I carcinogens by the International Agency for Research on Cancer. The other type of ICC is a cancer much rarer but present in the whole world. Some risk factors have been well-established (chronic inflammation of biliary ducts, hepatitis, thorotrast, etc) but many patients do not have any of these factors. An increase in incidence and mortality of this second type of ICC has been seen in recent years, mostly in developed countries. There is an ongoing discussion in the literature about its authenticity and potential causes.
de Martel
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C
International Agency for Research on Cancer (IARC), 150, cours Albert-Thomas, 69372 Lyon cedex 08, France.
Plummer
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Franceschi
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S
D000818:Animals; D001210:Asia, Southeastern / Q000453:epidemiology; D001650:Bile Duct Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000469:parasitology / Q000517:prevention & control; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000175:diagnosis / Q000453:epidemiology* / Q000469:parasitology / Q000517:prevention & control; D003003:Clonorchiasis / Q000150:complications; D003004:Clonorchis sinensis; D004502:Education, Medical, Continuing; D014943:Global Health; D006801:Humans; D015994:Incidence; D009889:Opisthorchiasis / Q000150:complications; D009891:Opisthorchis; D012307:Risk Factors