Variation of interstitial glucose measurements assessed by continuous glucose monitors in healthy, nondiabetic individuals.
OBJECTIVE
To characterize glucose levels during daily living using continuous glucose monitors (CGMs) in nondiabetic individuals.


METHODS
Seventy-four healthy children, adolescents, and adults aged 9-65 years with normal glucose tolerance used a blinded CGM device for 3 to 7 days.


RESULTS
Sensor glucose concentrations were 71-120 mg/dl for 91% of the day. Sensor values were <or=60 or >140 mg/dl for only 0.2% and 0.4% of the day, respectively. Sensor glucose concentrations were slightly higher in children than adults (P = 0.009) and were slightly lower during the night than day (95 vs. 99 mg/dl, P < 0.001).


CONCLUSIONS
Glucose values <or=60 and >140 mg/dl, measured with CGM, are uncommon in healthy, nondiabetic individuals. CGM may be useful to evaluate glucose tolerance in nondiabetic individuals over time. Furthermore, these data provide a basis for comparison for studies that use CGM to assess glucose control in subjects with diabetes.
Fox
Larry A
LA
Beck
Roy W
RW
Xing
Dongyuan
D
D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D015190:Blood Glucose Self-Monitoring; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory; D055815:Young Adult
D001786:Blood Glucose