Molecular mechanisms of membrane transport of vitamin E.
Vitamin E is an essential fat-soluble micronutrient for higher mammals and functions as an antioxidant for lipids and also as a regulator of gene expression and a modulator of cell signaling and proliferation. To exert its physiological functions, vitamin E must achieve an appropriate disposition throughout the body via several processes, such as intestinal absorption, uptake and efflux in peripheral tissues and biliary secretion. In this review, we mainly discuss membrane proteins involved in these transport processes (ATP-binding cassette transporter A1, scavenger receptor class B type I, Niemann-Pick C1-like 1 and multidrug resistance 3) and vitamin E-mediated regulation of their expression.
Takada
Tappei
T
Department of Pharmacy, The University of Tokyo Hospital, Faculty of Medicine, The University of Tokyo, Tokyo, Japan. tappei-tky@umin.ac.jp
Suzuki
Hiroshi
H
D064286:ATP Binding Cassette Transporter 1; D018435:ATP Binding Cassette Transporter, Subfamily B / Q000235:genetics / Q000378:metabolism; D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism; D001646:Bile / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D047908:Intracellular Signaling Peptides and Proteins; D008099:Liver / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D026901:Membrane Transport Proteins / Q000235:genetics / Q000378:metabolism*; D000077296:Niemann-Pick C1 Protein; D051122:Scavenger Receptors, Class B / Q000235:genetics / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism*
D064286:ATP Binding Cassette Transporter 1; D018435:ATP Binding Cassette Transporter, Subfamily B; D018528:ATP-Binding Cassette Transporters; D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; C106881:NPC1 protein, human; D000077296:Niemann-Pick C1 Protein; C495124:SCARB1 protein, human; D051122:Scavenger Receptors, Class B; D014810:Vitamin E; C095122:multidrug resistance protein 3