Accumulation of IL-17-positive cells in decidua of inevitable abortion cases.
OBJECTIVE
Th17 cells, a new subset of helper T cells, have been focused on as a producer pro-inflammatory cytokines. It is, however, still unknown how Th17 cells affect pregnancy outcome. We investigated the expression of IL-17-producing cells in human spontaneous abortion.


METHODS
IL-17 expression was analyzed in decidual tissues among normal pregnancy, missed abortion, and inevitable abortion cases by immunohistochemistry and flow cytometry.


RESULTS
IL-17+ cells were accumulated in decidua and were detected in decidual CD4+ T cells and few decidual CD8+ T cells in spontaneous abortion cases. The number of decidual IL-17+ cells in inevitable abortion cases involving active genital bleeding was significantly higher than that in normal pregnancy cases (P < 0.05). On the other hand, there were no significant differences in the numbers of decidual IL-17+ cells between missed abortion cases and normal pregnancy subjects. Furthermore, the number of IL-17+ cells was positively correlated with the number of neutrophils in spontaneous abortion cases.


CONCLUSIONS
IL-17+ cells might be involved in the induction of inflammation in the late stage of abortion, but not in the early stage of abortion.
Nakashima
Akitoshi
A
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, Toyama, Japan.
Ito
Mika
M
Shima
Tomoko
T
Bac
Nguyen Duy
ND
Hidaka
Takao
T
Saito
Shigeru
S
D000022:Abortion, Spontaneous / Q000276:immunology*; D003656:Decidua / Q000276:immunology*; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D020381:Interleukin-17 / Q000096:biosynthesis*; D011247:Pregnancy; D016176:T-Lymphocyte Subsets / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D020381:Interleukin-17