title: Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N-->S acyl transfer.
abstract: Sugars and simplified oligosaccharide "mimics" can be joined with protein fragments at pre-defined sites using reliable chemical reactions such as thiol alkylation and Cu(I) catalysed azide/acetylene ligation (click chemistry). These fragments have the potential to be assembled into neoglycoprotein therapeutics using native chemical ligation.
authors.affiliation: Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Richardson
authors.forename: Chung-Hei
authors.initials: CH
authors.lastname: Chan
authors.forename: Javier
authors.initials: J
authors.lastname: Blanc
authors.forename: Mona
authors.initials: M
authors.lastname: Saadi
authors.forename: Derek
authors.initials: D
authors.lastname: Macmillan
mesh_terms: D000595:Amino Acid Sequence; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry; D006020:Glycopeptides / Q000737:chemistry*; D006023:Glycoproteins / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009584:Nitrogen / Q000737:chemistry*; D009844:Oligosaccharides / Q000737:chemistry; D011487:Protein Conformation; D013379:Substrate Specificity; D013455:Sulfur / Q000737:chemistry*
chemical_list: D006020:Glycopeptides; D006023:Glycoproteins; D009844:Oligosaccharides; D013455:Sulfur; D009584:Nitrogen