title: Bone marrow micrometastases studied by an immunomagnetic isolation procedure in extremity localized non-metastatic osteosarcoma patients.
abstract: Hematogenous spread of tumor cells is an early event in osteosarcoma and present in the majority of patients at primary diagnosis. Eradication of such micrometastases by adjuvant combination chemotherapy is crucial for survival. However, a survival plateau of 60-70% was reached over two decades ago, above which it seems difficult to further advance with the currently available therapies. In this study we have, by an immunomagnetic isolation procedure, examined the presence and prognostic impact of disseminated tumor cells in bone marrow aspirates taken at primary diagnosis in a cohort of 41 non-metastatic patients with extremity localized, high-grade osteosarcoma.
authors.affiliation: Faculty of Medicine, University of Oslo and Department of Oncology, The Norwegian Radium Hospital, N-0310, Oslo, Norway. oyvind.bruland@medisin.uio.no
authors.forename: Øyvind S
authors.initials: ØS
authors.lastname: Bruland
authors.forename: Hanne
authors.initials: H
authors.lastname: Høifødt
authors.forename: Kirsten Sundby
authors.initials: KS
authors.lastname: Hall
authors.forename: Sigbjørn
authors.initials: S
authors.lastname: Smeland
authors.forename: Øystein
authors.initials: Ø
authors.lastname: Fodstad
mesh_terms: D000293:Adolescent; D000328:Adult; D019046:Bone Marrow Neoplasms / Q000556:secondary*; D001859:Bone Neoplasms / Q000401:mortality / Q000473:pathology*; D002648:Child; D005121:Extremities; D005260:Female; D006801:Humans; D018189:Immunomagnetic Separation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012516:Osteosarcoma / Q000401:mortality / Q000556:secondary*