title: The fate of Hancock II porcine valve recipients 25 years after implant.
abstract: OBJECTIVE
  The Hancock II (HII) is a second-generation porcine bioprosthesis introduced into clinical use in 1982. This study aimed to evaluate very long-term outcomes for the HII valve in a large patient population.
  
  
  METHODS
  Between May 1983 and November 1993, 517 consecutive patients (pts) (309 male, mean age: 64+/-9 years) underwent valve replacement (VR) surgery with HII, with 302 (58.4%) in the aortic VR (AVR) and 215 (41.6%) in the mitral VR (MVR) position, respectively. At implant, 106 pts (20.5%) were <60 years of age (G1), while 411 (79.5%) were > or =60 years of age (G2). The 25-year follow-up was complete for all pts at a median of 12 years (range: 0-25).
  
  
  RESULTS
  Long-term death occurred in 208 AVR and in 165 MVR pts. Survival at 15 and 20 years was 39.5% and 23.3% in AVR pts and 39.0% and 15.8% in MVR pts. At 25 years the survival of MVR pts was 13.7% (four pts at risk). Late freedom from re-operation was 85.5% and 79.3% at 15 and 20 years in the AVR pts and 73.3% and 52.8% in the MVR pts, respectively. In the AVR population, 20-year freedom from re-operation was 52.2% in G1 pts and 86.8% in G2 pts (p<0.0001), while in the MVR population it was 41.4% in G1 pts and 61.9% in G2 pts (p=0.201), respectively.
  
  
  CONCLUSIONS
  These results confirm the excellent long-term performance of the HII bioprosthesis.
authors.affiliation: Cardiovascular Surgery Department, Cà Foncello Hospital, Treviso, Italy. carlo.valfre@gmail.com
authors.forename: Carlo
authors.initials: C
authors.lastname: Valfrè
authors.forename: Paolo
authors.initials: P
authors.lastname: Ius
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Minniti
authors.forename: Loris
authors.initials: L
authors.lastname: Salvador
authors.forename: Tomaso
authors.initials: T
authors.lastname: Bottio
authors.forename: Francesco
authors.initials: F
authors.lastname: Cesari
authors.forename: Giulio
authors.initials: G
authors.lastname: Rizzoli
authors.forename: Gino
authors.initials: G
authors.lastname: Gerosa
mesh_terms: D000328:Adult; D000368:Aged; D001021:Aortic Valve / Q000601:surgery*; D001705:Bioprosthesis; D004812:Epidemiologic Methods; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery*; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D012086:Reoperation / Q000706:statistics & numerical data; D016896:Treatment Outcome; D055815:Young Adult