title: Estimating GFR in children with 99mTc-DTPA renography: a comparison with single-sample 51Cr-EDTA clearance.
abstract: Glomerular filtration rate (GFR) measurement by (51)Cr-ethylenediaminetetraacetic acid (EDTA) and blood sampling in children is usually cumbersome for the patient, parents and laboratory technicians. We have previously developed a method accurately estimating GFR in adults. The aim of the present study was to evaluate the accuracy of this non-invasive method in children. We calculated GFR from (99m)Tc-diethylene triamine pentaacetic acid (DTPA) renography and compared with (51)Cr-EDTA plasma clearance of 29 children between the age of 1 month and 12 years (mean 4.7 years). The correlation between (99m)Tc-DTPA renography and (51)Cr-EDTA plasma clearance was for all children R = 0.96 (n = 29, P<0.0001), for children above 2 years of age R = 0.96 (n = 18, P<0.0001) and for children <2 years R = 0.84 (n = 11, P<0.001). We conclude that assessment of GFR from (99m)Tc-DTPA renography is reliable and comparable to GFR calculated from (51)Cr-EDTA plasma clearance. Because our method is non-invasive and only takes 21 min, it may be preferable in many cases where an assessment of renal function is needed in children especially when renography is performed anyhow.
authors.affiliation: Department of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital, Rigshospitalet, Denmark. henrik.gutte@rh.regionh.dk
authors.forename: Henrik
authors.initials: H
authors.lastname: Gutte
authors.forename: Michael L
authors.initials: ML
authors.lastname: Møller
authors.forename: Andreas K
authors.initials: AK
authors.lastname: Pfeifer
authors.forename: Jørgen
authors.initials: J
authors.lastname: Thorup
authors.forename: Line
authors.initials: L
authors.lastname: Borgwardt
authors.forename: Lise
authors.initials: L
authors.lastname: Borgwardt
authors.forename: Ulrik S
authors.initials: US
authors.lastname: Kristoffersen
authors.forename: Andreas
authors.initials: A
authors.lastname: Kjaer
mesh_terms: D002648:Child; D002675:Child, Preschool; D002860:Chromium Radioisotopes / Q000493:pharmacokinetics; D004492:Edetic Acid / Q000493:pharmacokinetics*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000000981:diagnostic imaging / Q000378:metabolism*; D007674:Kidney Diseases / Q000000981:diagnostic imaging* / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D011866:Radioisotope Renography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D016284:Technetium Tc 99m Pentetate / Q000493:pharmacokinetics*
chemical_list: D002860:Chromium Radioisotopes; D019275:Radiopharmaceuticals; D004492:Edetic Acid; D016284:Technetium Tc 99m Pentetate