title: Feasibility of image-guided robotic radiotherapy using three fractions for uveal melanoma.
abstract: OBJECTIVE
  A retrospective study was performed to demonstrate the feasibility and efficacy of 3-fraction image-guided robotic stereotactic radiotherapy (fSRT) for uveal melanoma.
  
  
  METHODS
  Six patients with medium-sized or large tumors, who declined enucleation, were enrolled. The gross tumor volume (GTV) ranged from 454 to 2185 mm3. The total doses included 36 or 39 Gy in 3 fractions.
  
  
  RESULTS
  Follow-up ranged from 19 to 40 months. In 5 patients, the tumor mass gradually underwent an average 24.5% size reduction. All 3 patients with a GTV <1000 mm3 had a functional eye, while 3 patients with a GTV > or = 1000 mm3 did not have a functional eye. Radiation-induced complications occurred to some degree in all patients. However, complications that required enucleation were not detected.
  
  
  CONCLUSIONS
  We suggest that image-guided robotic radiotherapy using 3 fractions is a feasible and safe treatment option for patients with uveal melanoma. In cases of medium-sized and large tumors, fSRT could be used as an alternative treatment for cases ineligible for brachytherapy, but a longer follow-up and a larger number of patients are required to confirm the suitability of the method.
authors.affiliation: Department of Ophthalmology, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea.
authors.forename: Sang Yul
authors.initials: SY
authors.lastname: Choi
authors.forename: Mi-Sook
authors.initials: MS
authors.lastname: Kim
authors.forename: Sung Yul
authors.initials: SY
authors.lastname: Yoo
authors.forename: Chul Koo
authors.initials: CK
authors.lastname: Cho
authors.forename: Chang Hoon
authors.initials: CH
authors.lastname: Lhee
authors.forename: Dong Han
authors.initials: DH
authors.lastname: Lee
authors.forename: Jin Kyu
authors.initials: JK
authors.lastname: Kang
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Shin
mesh_terms: D000328:Adult; D000368:Aged; D019583:Dose Fractionation, Radiation; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000532:radiotherapy / Q000601:surgery*; D008875:Middle Aged; D016634:Radiosurgery; D011879:Radiotherapy Dosage; D012371:Robotics; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014604:Uveal Neoplasms / Q000532:radiotherapy / Q000601:surgery*