[Preparation and in vitro release characteristics of curcumin loaded biodegradable microspheres].
OBJECTIVE
To prepare curcumin-loaded poly-(D,L-lactide-co-glycolide) microspheres and study its release characteristics in vitro.


METHODS
Curcumin-loaded poly-(D,L-lactide-co-glycolide) microspheres were prepared by W/O/W emulsification solvent-evaporation process. The microspheres were characterized in terms of morphology, size, encapsulation efficiency, the rate of drug loading and in vitro drug release.


RESULTS
The formed microspheres were spherical with smooth surfaces. The distribution of particle size was uniform and average size was 1 151 nm. The rate of drug loading was (1.98 +/- 0.14)% and the encapsulation efficiency was (59.44 +/- 4.05)%. In vitro release study revealed that the 71-hour accumulative release percentage reached 77%.


CONCLUSIONS
Curcumin loaded poly-(D,L-lactide-co-glycolide) microspheres are prepared successfully and show good sustained-release characteristics.
Wang
Haiou
H
Chongqing Key Laboratory of Biochemistry & Molecular Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Li
Pan
P
Zhang
Liangke
L
Zhang
Jingqing
J
Ling
Xu
X
Ran
Haitao
H
D001672:Biocompatible Materials / Q000737:chemistry*; D003474:Curcumin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size; D011098:Polyglactin 910 / Q000737:chemistry
D001672:Biocompatible Materials; D004337:Drug Carriers; D011098:Polyglactin 910; D003474:Curcumin