title: Perioperative coagulation profile in living liver donors as assessed by rotational thromboelastometry.
abstract: Transient postoperative coagulation abnormalities frequently occur in living liver donors, particularly after right liver resection. Usually, this coagulopathy is diagnosed by alterations in conventional coagulation tests (CCTs) such as the international normalized ratio (INR) of the prothrombin time. However, recent studies using other methods of coagulation monitoring have suggested that postoperative hypercoagulability may also occur in living donors. The rotational thromboelastometry (ROTEM) system is a coagulation monitor based on the viscoelastic properties of blood. The use of ROTEM for perioperative coagulation monitoring in the setting of living liver donors has not been reported. We evaluated the perioperative coagulation profile as assessed by ROTEM in 16 consecutive donors who underwent either right or left liver resection at our institution. ROTEM analysis and CCTs were performed at the baseline (before skin incision) and on postoperative days 1 and 3. According to the CCTs, hypocoagulability was revealed in all but 1 (left liver) donor. The INR was highest on postoperative day 1 [median = 1.67 (interquartile range = 1.37-1.8)]. In contrast, all donors had a normal coagulation profile as assessed by the ROTEM system throughout the study period. In conclusion, this study showed the disagreement between the CCTs and the ROTEM system, as no significant coagulation abnormalities could be revealed with the latter method during the study period. Further studies are needed to confirm the role of the ROTEM system as a perioperative coagulation monitor in this setting and ultimately its influence on the outcome of living donors.
authors.affiliation: Department of Anesthesiology, Bonsucesso General Hospital, Rio de Janeiro, Brazil. glaubergouvea@ibest.com.br
authors.forename: Glauber
authors.initials: G
authors.lastname: Gouvêa
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Diaz
authors.forename: Lúcio
authors.initials: L
authors.lastname: Auler
authors.forename: Renato
authors.initials: R
authors.lastname: Toledo
authors.forename: André
authors.initials: A
authors.lastname: Soluri
authors.forename: Alfredo G
authors.initials: AG
authors.lastname: Haack
authors.forename: Mariana M
authors.initials: MM
authors.lastname: de Oliveira
authors.forename: Bruno
authors.initials: B
authors.lastname: Vilanova
authors.forename: Virgínia R
authors.initials: VR
authors.lastname: Machado
authors.forename: José Manoel
authors.initials: JM
authors.lastname: Martinho
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000502:physiology; D001778:Blood Coagulation Disorders / Q000097:blood / Q000175:diagnosis*; D001780:Blood Coagulation Tests / Q000295:instrumentation / Q000379:methods; D004548:Elasticity / Q000502:physiology; D005260:Female; D006801:Humans; D008099:Liver / Q000601:surgery; D016031:Liver Transplantation; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation* / Q000379:methods; D019990:Perioperative Care / Q000295:instrumentation* / Q000379:methods; D012189:Retrospective Studies