title: Health-related quality of life and long-term mortality in patients treated with percutaneous coronary intervention.
abstract: BACKGROUND
  Health status has become increasingly important as an outcome measure in patients with cardiovascular disease. Poor patient-rated health status has been shown to predict mortality in patients with coronary artery disease and heart failure. In patients treated with percutaneous coronary intervention (PCI), we examined whether poor health status predicts 6-year mortality and whether a decline in health status is associated with adverse clinical outcome.
  
  
  METHODS
  Consecutive patients (N = 872) treated with PCI as part of the RESEARCH registry, completed the 36-item Short-Form Health Survey (SF-36) at 1 and 12 months post-PCI.
  
  
  RESULTS
  The SF-36 domains physical functioning (hazard ratio [HR] 2.59, 95% CI 1.61-4.16), social functioning (HR 2.76, 95% CI 1.74-4.37), role limitations due to physical functioning (HR 2.45, CI 1.52-3.92), mental health (HR 2.12, 95% CI 1.35-3.31), vitality (HR 1.73, 95% CI 1.09-2.74), bodily pain (HR 2.25, 95% CI 1.43-3.54), and general health (HR 2.46, 95% CI 1.57-3.87) were associated with 6-year mortality. A decline in health status was not related with higher 6-year mortality.
  
  
  CONCLUSIONS
  Health status domains as measured with the SF-36 predicted death at 6-year follow-up in PCI patients treated with drug-eluting stenting, independent of demographic and clinical characteristics. In contrast, a decline in health status between 1 and 12 months post index procedure, as measured with the SF-36, was not associated with 6-year mortality in PCI patients treated with drug-eluting stenting.
authors.affiliation: Department of Cardiology, Thoraxcenter, Erasmus Medical Center Rotterdam, The Netherlands.
authors.forename: Lisanne
authors.initials: L
authors.lastname: Schenkeveld
authors.forename: Susanne S
authors.initials: SS
authors.lastname: Pedersen
authors.forename: Josephine W I
authors.initials: JW
authors.lastname: van Nierop
authors.forename: Mattie J
authors.initials: MJ
authors.lastname: Lenzen
authors.forename: Peter P T
authors.initials: PP
authors.lastname: de Jaegere
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
authors.forename: Ron T
authors.initials: RT
authors.lastname: van Domburg
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000401:mortality*; D005260:Female; D006304:Health Status; D006801:Humans; D007398:Interpersonal Relations; D053208:Kaplan-Meier Estimate; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D010146:Pain / Q000503:physiopathology; D010809:Physical Fitness; D011237:Predictive Value of Tests; D011788:Quality of Life; D013997:Time Factors