Pro-oxidant action of pyrroloquinoline quinone: characterization of protein oxidative modifications.
Pyrroloquinoline quinone (PQQ), a putative essential nutrient, is a redox modulator in cell and animal models. Here we characterized PQQ-induced protein oxidative modifications in a model peptide and protein, and we propose that the mechanism of protein modification by PQQ is redox cycling-mediated oxidation. PQQ may contribute to the regulation of intracellular protein functions through its prooxidant action.
Ishii
Takeshi
T
Department of Food and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan. ishii_t@u-shizuoka-ken.ac.jp
Akagawa
Mitsugu
M
Naito
Yuji
Y
Handa
Osamu
O
Takagi
Tomohisa
T
Mori
Taiki
T
Kumazawa
Shigenori
S
Yoshikawa
Toshikazu
T
Nakayama
Tsutomu
T
D000975:Antioxidants / Q000737:chemistry; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D045542:PQQ Cofactor / Q000737:chemistry*; D050050:Protein Carbonylation; D011506:Proteins / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry*
D000975:Antioxidants; D011506:Proteins; D017382:Reactive Oxygen Species; D045542:PQQ Cofactor