title: The 3020insC Allele of NOD2 Predisposes to Cancers of Multiple Organs.
abstract: The NOD2 gene has been associated with susceptibility to Crohn's disease and individuals with Crohn's disease are at increased risk for cancer at a number of organ sites. We studied the association between the 3020insC allele of the NOD2 gene and cancer among 2604 cancer patients and 1910 controls from Poland. Patients were diagnosed with one of twelve types of cancer in the Szczecin region between 1994 and 2004. Significant associations were found for colon cancer (OR = 1.8; 95% CI 1.2 to 2.6), for lung cancer (OR = 1.7; 95% CI = 1.1 to 2.5) and for ovarian cancer (OR = 1.6; 95% CI 1.1 to 2.3). In addition, a significant association was found for early-onset laryngeal cancer (OR = 2.9; 95% CI 1.4 to 6.2) and for breast cancer in the presence of DCIS (OR = 2.1 95% CI = 1.2 to 3.6). The NOD2 3020insC allele is relatively common (in Poland 7.3% of individuals) and may be responsible for an important fraction of cancer cases. We estimate that the lifetime cancer risk among carriers of this allele is 30% higher than that of individuals with two wild-type alleles.
authors.affiliation: Pomeranian Medical University, Szczecin, Poland. lubinski@sci.pam.szczecin.pl.
authors.forename: Jan
authors.initials: J
authors.lastname: Lubiński
authors.forename: Tomasz
authors.initials: T
authors.lastname: Huzarski
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Kurzawski
authors.forename: Janina
authors.initials: J
authors.lastname: Suchy
authors.forename: Bartłomiej
authors.initials: B
authors.lastname: Masojć
authors.forename: Marek
authors.initials: M
authors.lastname: Mierzejewski
authors.forename: Marcin
authors.initials: M
authors.lastname: Lener
authors.forename: Wenancjusz
authors.initials: W
authors.lastname: Domagała
authors.forename: Maria
authors.initials: M
authors.lastname: Chosia
authors.forename: Urszula
authors.initials: U
authors.lastname: Teodorczyk
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Medrek
authors.forename: Tadeusz
authors.initials: T
authors.lastname: Debniak
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Złowocka
authors.forename: Jacek
authors.initials: J
authors.lastname: Gronwald
authors.forename: Tomasz
authors.initials: T
authors.lastname: Byrski
authors.forename: Ewa
authors.initials: E
authors.lastname: Grabowska
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Nej
authors.forename: Anna
authors.initials: A
authors.lastname: Szymańska
authors.forename: Jolanta
authors.initials: J
authors.lastname: Szymańska
authors.forename: Joanna
authors.initials: J
authors.lastname: Matyjasik
authors.forename: Cezary
authors.initials: C
authors.lastname: Cybulski
authors.forename: Anna
authors.initials: A
authors.lastname: Jakubowska
authors.forename: Bohdan
authors.initials: B
authors.lastname: Górski
authors.forename: Steven A
authors.initials: SA
authors.lastname: Narod