T cell Ig and mucin domain proteins and immunity.
Proteins of the transmembrane (or T cell) Ig and mucin domain (TIM) family are expressed by multiple cell types within the immune systems of rodents and humans. Studies over the last several years have suggested that these proteins may be promising targets for therapeutic manipulation of immune responses. This review discusses the progress that has been made in understanding TIM protein function in the immune system, as well as some of the unresolved issues that remain on the road to eventually targeting TIM proteins for enhancing or inhibiting immunity.
Kane
Lawrence P
LP
Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. lkane@pitt.edu
D000818:Animals; D018797:Cell Cycle Proteins / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D008565:Membrane Proteins / Q000145:classification / Q000276:immunology / Q000378:metabolism; D051379:Mice; D009077:Mucins / Q000502:physiology*; D017434:Protein Structure, Tertiary; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism
D018797:Cell Cycle Proteins; D007136:Immunoglobulins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009077:Mucins; C509769:TIMELESS protein, human; C509770:Timeless protein, mouse