Advances in the preparation of porous polymer monoliths in capillaries and microfluidic chips with focus on morphological aspects.
Porous polymer monoliths have emerged as unique materials for many applications, including liquid-chromatographic analyses at an unrivaled speed, solid-phase extraction, and enzyme immobilization in capillary and microfluidic chip format. This article reviews the state of the art in the preparation of monoliths in narrow-bore capillaries and microfluidic chips and their miniaturization under conditions of spatial confinement. New developments in their preparation mainly using free radical polymerization techniques with a focus on morphological aspects in view of homogeneous porous materials are described. The suitability of monoliths for analysis of both large and small molecules is also discussed.
Nischang
Ivo
I
Institute of Polymer Chemistry, Johannes Kepler University Linz, Welser Strasse 42, 4060 Leonding, Austria. ivo.nischang@jku.at
Brueggemann
Oliver
O
Svec
Frantisek
F