title: [Correlation between HLA-DRB1*0901 and 1501, HLA-DQB1*0301 and 0602 alleles and esophageal squamous cell carcinoma of Kazakh in Xinjiang, China].
abstract: OBJECTIVE
  To investigate the polymorphism of HLA-DRB1 and DQB1 allele in esophageal squamous cell carcinomas of Kazakh in Xinjiang, and to characterize susceptible genes for the family of Kazakh esophageal squamous cell carcinoma.
  
  
  METHODS
  HLA-DRB1*0901, DRB1*1501, DQB1*0301, DQB1*0602 alleles were genotyped by sequence specific primers using polymerase chain reaction (PCR-SSP) in 200 Kazakh esophageal squamous cell carcinoma and 177 normal esophageal mucosa.
  
  
  RESULTS
  The frequency of HLA-DRB1*1501, HLA-DQB1*0301, HLA-DQB1*0602 alleles in 200 Kazakh esophageal squamous cell carcinoma (0.455, 0.760 and 0.690) were significantly higher than that of 177 normal esophageal mucosa (0.232, 0.520, 0.554; OR = 2.78, 2.93, 1.80; P < 0.05). The frequency of HLA-DRB1*0901 between the carcinoma (0.105) and control groups (0.102) had no association (OR = 1.036, P > 0.05); The frequency of HLA-DQB1*0602 was higher in poor-differentiated squamous cell carcinomas (0.742) than that of well-differentiated tumors (0.597, P < 0.05).
  
  
  CONCLUSIONS
  HLA-DRB1*1501, HLA-DQB1*0301, HLA-DQB1* 0602 may be susceptible to Kazakh esophageal squamous cell carcinoma. HLA-DQB1*0602 correlates with well-differentiated esophageal squamous cell carcinoma.
authors.affiliation: Department of Pathology, College of Medicine, Shihezi University, Shihezi 832002, China.
authors.forename: Yun-zhao
authors.initials: YZ
authors.lastname: Chen
authors.forename: Jian-ming
authors.initials: JM
authors.lastname: Hu
authors.forename: Chun-xia
authors.initials: CX
authors.lastname: Liu
authors.forename: Lan
authors.initials: L
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Qi
authors.forename: Wen-ting
authors.initials: WT
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Yin
authors.forename: Hong-an
authors.initials: HA
authors.lastname: Li
authors.forename: Jin-fang
authors.initials: JF
authors.lastname: Jiang
authors.forename: Wei-hua
authors.initials: WH
authors.lastname: Liang
authors.forename: Feng
authors.initials: F
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D002681:China / Q000208:ethnology; D004198:Disease Susceptibility; D004938:Esophageal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D005787:Gene Frequency; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged
chemical_list: D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C487381:HLA-DRB1*09:01 antigen; C489631:HLA-DRB1*15:01 antigen; D008562:Membrane Glycoproteins