Procalcitonin as a prognostic marker in patients with acute myocardial infarction.
BACKGROUND
Procalcitonin is involved in the inflammatory response and is associated with adverse prognosis in certain conditions.


OBJECTIVE
To investigate the association between procalcitonin and major adverse cardiac events (MACE), left ventricular (LV) function and remodelling following acute myocardial infarction (AMI).


METHODS
Plasma procalcitonin was measured in 977 patients with AMI. Subjects were followed for MACE (median 671 days). A subgroup underwent echocardiography at discharge and follow-up LV function and volume assessment.


RESULTS
Procalcitonin was associated with MACE on uni- and multivariable analysis. Kaplan-Meier assessment revealed an adverse outcome in subjects with procalcitonin above the median. Procalcitonin was related to markers of LV dysfunction and remodelling.


CONCLUSIONS
Procalcitonin is associated with MACE, LV dysfunction and remodelling post-AMI.
Kelly
Dominic
D
Department of Cardiovascular Sciences, University of Leicester, Leicester Royal Infirmary, Leicester, UK. kelly.dominic@talk21.com
Khan
Sohail Q
SQ
Dhillon
Onkar
O
Quinn
Paulene
P
Struck
Joachim
J
Squire
Iain B
IB
Davies
Joan E
JE
Ng
Leong L
LL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002116:Calcitonin / Q000097:blood*; D015740:Calcitonin Gene-Related Peptide; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D011498:Protein Precursors / Q000097:blood*
D015415:Biomarkers; C000606589:CALCA protein, human; D011498:Protein Precursors; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide