[Determinants of long-term survival after pancreaticoduodenectomy for ampulla of Vater carcinoma].
OBJECTIVE
To investigate the determinants of long-term survival for ampulla of Vater carcinoma treated by pancreaticoduodenectomy.


METHODS
A total of 77 patients with ampulla of Vater carcinoma undergoing pancreaticoduodenectomy were reviewed. Kaplan-Meier method was used to analyze the survival rate. Independent t test was used for statistical comparison and COX regression model for multivariate analysis.


RESULTS
No patient died as a result of surgery. The overall 5-year survival was 40.7%. Univariate analysis showed that perioperative serum carcinoembryonic antigen (CEA) level (P = 0.012), tumor invasion depth (P = 0.000), UICC stage (P = 0.000) and tumor size (P = 0.001) were significant prognostic factors of ampulla of Vater carcinoma; in multivariate analysis, only the tumor size (P = 0.000) was an independent prognostic factor of ampulla of Vater carcinoma.


CONCLUSIONS
Pancreaticoduodenectomy is associated with significant survival. Tumor size is the most important influencing factor of outcome after pancreaticoduodenectomy; in addition, perioperative serum CEA level, tumor invasion depth and UICC stage may also influence the survival rate, there exists a need for further follow-up studies.
Chen
Ji-ye
JY
Department of Hepatobiliary Surgery, General Hospital of PLA, Beijing 100853, China.
Cai
Shou-wang
SW
Zhang
Wen-zhi
WZ
Huang
Xiao-qiang
XQ
Liu
Rong
R
Wang
Jing
J
Chen
Yong-liang
YL
Ji
Wen-bin
WB
Shi
Xian-jie
XJ
Chen
Ming-yi
MY
Liu
Zhi-wei
ZW
Zhao
Xiang-qian
XQ
Feng
Yu-quan
YQ
Huang
Zhi-qiang
ZQ
Dong
Jia-hong
JH
D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000601:surgery*; D002277:Carcinoma / Q000401:mortality / Q000601:surgery*; D003138:Common Bile Duct Neoplasms / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016577:Pancreaticoduodenectomy / Q000401:mortality*; D011379:Prognosis; D016016:Proportional Hazards Models; D015996:Survival Rate