Pd(II)-catalyzed synthesis of carbolines by iminoannulation of internal alkynes via direct C-H bond cleavage using dioxygen as oxidant.
A palladium-catalyzed iminoannulation of internal alkynes via direct C-H bond cleavage was developed. Dioxygen was employed as a clean oxidant in this kind of catalysis. Carbolines were synthesized from tert-butylimines of N-substituted indole-2-carboxaldehydes or indole-3-carboxaldehydes.
Ding
Shengtao
S
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100191, China.
Shi
Zhuangzhi
Z
Jiao
Ning
N
D000480:Alkynes / Q000737:chemistry*; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
D000480:Alkynes; D002243:Carbolines; D010165:Palladium; D010100:Oxygen