Celecoxib in a 12-year-old boy with familial adenomatous polyposis.
Familial Adenomatous Polyposis (FAP) is an autosomal dominant disorder characterized by colonic polyps in early adult life. Children with this disease are at risk for colonic cancer, so prophylactic colectomy is the standard treatment to prevent this complication. Chemoprevention experience with NSAIDs in children is exceptional. This case report describes our experience with Celecoxib, a COX-2 inhibitor, in a 12-year-old boy.
Pérez-Segura
P
P
Department of Oncology, Hospital Clínico San Carlos, Madrid, Spain.
Bodas
A
A
Sereno
M
M
Martínez-Amores
B
B
Olivera
H
H
Díaz
S
S
López-Asenjo
J A
JA
Puente
J
J
Maluenda
C
C
Díaz-Rubio
E
E
D011125:Adenomatous Polyposis Coli / Q000188:drug therapy*; D000068579:Celecoxib; D002648:Child; D052246:Cyclooxygenase 2 Inhibitors / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011720:Pyrazoles / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*; D016896:Treatment Outcome
D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib