Glucose intolerance and cardiometabolic risk in adolescents exposed to maternal gestational diabetes: a 15-year follow-up study.
OBJECTIVE
Adolescent offspring of women with a history of gestational diabetes (GD) were evaluated for their cardiometabolic risks at a mean age of 15 years.


METHODS
One hundred and twenty-nine adolescents who were assessed for their cardiometabolic risks at 8 years of age were reassessed at 15 years of age.


RESULTS
Adolescent offspring of mothers with GD had similar blood pressure, plasma lipid profile, and a rate of abnormal glucose tolerance as control subjects. In utero hyperinsulinemia was associated with a 17-fold increase in metabolic syndrome and a 10-fold increase in overweight at adolescence, independent of birth weight, Tanner stage, maternal GD status, and mother's BMI.


CONCLUSIONS
In utero environment of hyperinsulinemia, irrespective of the degree of maternal GD, was associated with increased risk of overweight and metabolic syndrome during early adolescence in the offspring.
Tam
Wing Hung
WH
Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong SAR. tamwh@cuhk.edu.hk
Ma
Ronald Ching Wan
RC
Yang
Xilin
X
Li
Albert Martin
AM
Ko
Gary Tin Choi
GT
Kong
Alice Pik Shan
AP
Lao
Terence Tzu Hsi
TT
Chan
Michael Ho Ming
MH
Lam
Christopher Wai Kei
CW
Chan
Juliana Chung Ngor
JC
D000293:Adolescent; D002648:Child; D016640:Diabetes, Gestational / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000097:blood / Q000453:epidemiology*; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications / Q000503:physiopathology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000453:epidemiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000097:blood / Q000453:epidemiology