Adverse drug reactions in an Iranian department of adult infectious diseases.
This study aimed to assess the frequency and severity of adverse drug reactions (ADRs) (WHO definition) in hospitalized adult patients in an infectious diseases referral ward in Tehran. Of 281 patients evaluated over 6 months, a total of 170 suspected ADRs were reported among 101 patients (35.9%). The most commonly affected organ system was gastrointestinal (47.5%), and the most common class of drugs responsible was anti-infectives (93.1%). ADRs were high among HIV-positive patients (82.9%), mainly due to anti-tuberculosis drugs. Attention to appropriate prescription of drugs is required with more careful clinical and laboratory monitoring of patients.
Kourorian
Z
Z
Immunology, Asthma and Allergy Research Institute, Children's Medical Centre, Tehran, Islamic Republic of Iran.
Fattahi
F
F
Pourpak
Z
Z
Rasoolinejad
M
M
Gholami
K
K
D000328:Adult; D000704:Analysis of Variance; D000890:Anti-Infective Agents / Q000009:adverse effects; D016009:Chi-Square Distribution; D003141:Communicable Diseases / Q000150:complications / Q000188:drug therapy*; D003430:Cross-Sectional Studies; D016903:Drug Monitoring; D011307:Drug Prescriptions; D064420:Drug-Related Side Effects and Adverse Reactions / Q000139:chemically induced* / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000453:epidemiology; D015658:HIV Infections / Q000150:complications; D006779:Hospitals, Public; D006784:Hospitals, Teaching; D006801:Humans; D007297:Inpatients / Q000706:statistics & numerical data*; D007492:Iran / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012307:Risk Factors
D000890:Anti-Infective Agents