[Differential diagnostic importance of immunochistochemistry applied at metastases of adenocarcinomas of the peritoneum].
Patients with metastatic carcinomas with unclear primary tumor site are often clinical and pathological problem. They are diagnosed in about 3-65 of the cases with solid tumors. In 60% of cases the reason is adenocarcinomas. The most frequent reason for peritoneal carcinomas at women is the ovarian cancer. In such cases we must exclude the probability of colorectal cancer. In fact there are not international standards for prove the origin of adenocarcinomas; different research groups use different criteria. We present the use of four antibodies--Cytokeratin 7 and 20, Beta cathenin and CDX2 and define their positiveness at metastases from different groups of adenocarcinomas in the peritoneum.
Porjazova
E
E
Zaprjanov
Z
Z
Batashki
I
I
Milchev
N
N
Markova
D
D
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000276:immunology / Q000556:secondary*; D000071616:CDX2 Transcription Factor; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D053554:Keratin-20 / Q000235:genetics / Q000378:metabolism; D053552:Keratin-7 / Q000235:genetics / Q000378:metabolism; D008297:Male; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology*; D010537:Peritoneum / Q000473:pathology; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism
D000071616:CDX2 Transcription Factor; C491270:CDX2 protein, human; D018398:Homeodomain Proteins; D053554:Keratin-20; D053552:Keratin-7; D051176:beta Catenin