[Assessment of effectiveness and immunogenicity of hepatitis A vaccination in servicemen of Internal Forces of Ministry of Internal Affairs of Russia].
OBJECTIVE
Comarative assessment of immunological and epidemiological effectiveness of hepatitis A vaccination and duration of immunity after immunization in servicemen.


METHODS
During 1996-2003, immunogenicity and epidemiologic effectiveness of 3 vaccines against hepatitis A--Havrix 1440 (GlaxoSmithKline, Belgium), Hep-A-in-Vac (Chumakov Institute of Poliomyelitis and Viral Encephalitides, Russia), and Avaxim (Sanofi Pasteur, France)--were evaluated. More than 15,000 servicemen were immunized during that time. In all cases one-dose vaccination without booster was performed.


RESULTS
Several cases of acute hepatitis A were registered 12 months and 6-8 months after vaccination in military communities immunized with Havrix 1440 and Hep-A-in-Vac vaccines respectively. Usage of Avaxim vaccine as a single dose in field trials allowed to exclude new cases of acute hepatitis A during time of military service. It was shown that 5 years after single vaccination with Avaxim protective anti-HAV antibody level (20 IU/l) persisted in 90% of Internal Forces servicemen.


CONCLUSIONS
On the basis of performed complex of studies, system of antiepidemic measures was developed, which leads to decrease of hepatitis A incidence. Selective immunization is proposed.
Sabanin
Iu V
IuV
Rikhter
V V
VV
Kuzin
S N
SN
D006506:Hepatitis A / Q000276:immunology* / Q000517:prevention & control*; D035922:Hepatitis A Antibodies / Q000097:blood*; D022362:Hepatitis A Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D008889:Military Personnel; D012426:Russia
D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines