Subcellular localization of a fluorescent artemisinin derivative to endoplasmic reticulum.
A cytotoxic artemisinin derivative conjugated with a fluorescent dansyl moiety was synthesized and its subcellular localization in Hep3B cells was examined. Comparison of the localization signals of the fluorescent artemisinin derivative with organelle specific dyes revealed that endoplasmic reticulum (ER) is the main site of its accumulation.
Liu
Yungen
Y
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
Lok
Chun-Nam
CN
Ko
Ben Chi-Bun
BC
Shum
Tina Yuen-Ting
TY
Wong
Man-Kin
MK
Che
Chi-Ming
CM
D000970:Antineoplastic Agents / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D037621:Artemisinins / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005453:Fluorescence; D006801:Humans; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
D000970:Antineoplastic Agents; D037621:Artemisinins; C031327:artemisinin