title: Can treatment delay be utilized as a key variable for monitoring the pool of infectious tuberculosis in a population?
abstract: BACKGROUND
  A major goal of tuberculosis control programs is to stop community transmission of Mycobacterium tuberculosis. However, this can not be rapidly accomplished because, in endemic areas, most of the population is already infected, serving as a reservoir that continuously contributes to the pool of infectious cases. Tuberculin surveys are the main tools used to monitor the infectious pool, but there are serious methodological constraints, and they require resources and expertise that are often unavailable. There is an urgent need for alternative means to monitor the epidemic at the local level.
  
  
  METHODS
  We investigated whether a systematic registration of treatment delay in the tuberculosis program records of the Amhara Region of Ethiopia could be utilized to estimate the infectious pool of tuberculosis.
  
  
  RESULTS
  The study showed that the total number of infectious days and hence an estimate of the infectious pool could be calculated by recording the treatment delay for new TB cases, retreatment cases and failures, and by estimating the number of undiagnosed cases. Of these categories, treatment delay among new smear-positive tuberculosis cases contributes the greatest number of infectious days.
  
  
  CONCLUSIONS
  A local tuberculosis program can use a systematic recording of treatment delay as a quantifiable variable to monitor the infectious pool, and can also serve as a key indicator of program performance.
authors.affiliation: Department of International Health, Institute of General Practice and Community Medicine, University of Oslo, Norway. dgstorla@online.no
authors.forename: Dag G
authors.initials: DG
authors.lastname: Storla
authors.forename: Solomon
authors.initials: S
authors.lastname: Yimer
authors.forename: Gunnar A
authors.initials: GA
authors.lastname: Bjune
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D005002:Ethiopia / Q000453:epidemiology; D006801:Humans; D011159:Population Surveillance / Q000379:methods*; D019233:Retreatment; D013997:Time Factors; D017211:Treatment Failure; D014376:Tuberculosis / Q000188:drug therapy* / Q000453:epidemiology*
chemical_list: D000995:Antitubercular Agents