Protein synthesis and degradation are required for the incorporation of modified information into the pre-existing object-location memory.
Although some reports indicate that protein synthesis dependent process may be induced by updating information, the role of protein synthesis and degradation in changing the content of pre-existing memory is yet unclear. In this study, we utilized an object rearrangement task, in which partial information related to a pre-existing memory is changed, promoting memory modification. Inhibitors of both protein synthesis and protein degradation impaired adequate incorporation of the altered information, each in a distinctive way. These results indicate that protein synthesis and degradation play key roles in memory modification.
Choi
Jun-Hyeok
JH
National Creative Research Initiative Center for Memory, Department of Biological Sciences, College of Natural Sciences, Seoul National University, 151-742 Seoul, Korea.
Kim
Jung-Eun
JE
Kaang
Bong-Kiun
BK
D000818:Animals; D000841:Anisomycin / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D009483:Neuropsychological Tests; D014176:Protein Biosynthesis / Q000187:drug effects / Q000502:physiology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism*
D011500:Protein Synthesis Inhibitors; D011506:Proteins; D000841:Anisomycin