title: [Increased level of prostate-specific antigen: a diagnostic marker of hyperandrogenism women].
abstract: OBJECTIVE
  To determine whether the increased level of serum prostate-specific antigen (PSA) could be used as a diagnostic marker of hyperandrogenism in women.
  
  
  METHODS
  Forty-five female patients with hyperandrogenism and 50 healthy control women were detected for the levels of serum PSA, testosterone (T), sex hormone binding globulin (SHBG) and dehydroepiandrosterone sulfate (DHEA-S). The results were statistically analyzed.
  
  
  RESULTS
  The level of serum PSA was found to be significantly higher in the hyperandrogenism patients than in the healthy controls (9.72 +/- 1.39 pg/ml vs 3.56 +/- 0.44 pg/ml, P < 0.01), and it showed a weak positive correlation with T (r = 0.226, P < 0.05) and DHEA-S (r = 0.255, P < 0.05), and a weak negative correlation with SHBG (r = -0,228, P < 0.05).
  
  
  CONCLUSIONS
  The increased level of PSA could be used as a diagnostic marker of hyperandrogenism in females.
authors.affiliation: PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China. ghw54321@sina.com
authors.forename: Guo-Hong
authors.initials: GH
authors.lastname: Wang
authors.forename: Rui-Ji
authors.initials: RJ
authors.lastname: Xu
authors.forename: Zhong-Shu
authors.initials: ZS
authors.lastname: Zhang
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood* / Q000175:diagnosis*; D017430:Prostate-Specific Antigen / Q000097:blood*; D012738:Sex Hormone-Binding Globulin; D055815:Young Adult
chemical_list: D012738:Sex Hormone-Binding Globulin; D017430:Prostate-Specific Antigen