title: Protective effects of Cinnamomum cassia Blume in the fibrogenesis of activated HSC-T6 cells and dimethylnitrosamine-induced acute liver injury in SD rats.
abstract: Cinnamomum cassia Blume (CC) is one of the world's oldest natural spices, and is commonly used in traditional oriental medicine. We investigated the protective effect of ethanol extract from Cinnamomum cassia Blume (CCE) on the activation of hepatic stellate cells (HSCs). In addition, we examined the effects of CC powder in Sprague-Dawley rats with acute liver injury induced by dimethylnitrosamine (DMN). In vitro, HSC-T6 cells exhibit an activated phenotype, as reflected in their fibroblast-like morphology. CCE significantly reduced the expression of alpha-smooth muscle actin (alpha-SMA), connective tissue growth factor (CTGF), transforming growth factor beta (TGF-beta1), and tissue inhibitor of metalloproteinase-1 (TIMP-1). In vivo, the results were significantly protected by CC powder in the serum total protein, albumin, total-bilirubin, direct-bilirubin, glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and alkaline phosphatase (ALP). We suggest that CC inhibits fibrogenesis, followed by HSC-T6 cell activation and increased restoration of liver function, ultimately resulting in acute liver injury.
authors.affiliation: College of Oriental Medicine and Institute of Oriental Medicine, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Chang-Shin
authors.initials: CS
authors.lastname: Lim
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Kim
authors.forename: Hyun-Sam
authors.initials: HS
authors.lastname: Lee
authors.forename: Yunjo
authors.initials: Y
authors.lastname: Soh
authors.forename: Youngjoo
authors.initials: Y
authors.lastname: Sohn
authors.forename: Sun Yeou
authors.initials: SY
authors.lastname: Kim
authors.forename: Nak-Won
authors.initials: NW
authors.lastname: Sohn
authors.forename: Hyuk-Sang
authors.initials: HS
authors.lastname: Jung
authors.forename: Yoon-Bum
authors.initials: YB
authors.lastname: Kim
mesh_terms: D000199:Actins / Q000037:antagonists & inhibitors; D000818:Animals; D032904:Cinnamomum aromaticum / Q000737:chemistry*; D055513:Connective Tissue Growth Factor / Q000037:antagonists & inhibitors; D019610:Cytoprotection; D004128:Dimethylnitrosamine / Q000633:toxicity*; D055166:Hepatic Stellate Cells / Q000187:drug effects*; D008099:Liver / Q000187:drug effects; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000517:prevention & control*; D008111:Liver Function Tests; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000037:antagonists & inhibitors; D053773:Transforming Growth Factor beta1 / Q000037:antagonists & inhibitors
chemical_list: D000199:Actins; D055513:Connective Tissue Growth Factor; D004128:Dimethylnitrosamine; D010936:Plant Extracts; D019715:Tissue Inhibitor of Metalloproteinase-1; D053773:Transforming Growth Factor beta1; C498862:Acta2 protein, rat