Biomedical research of novel biodegradable copoly(amino acid)s based on 6-aminocaproic acid and L-proline.
The biomedical properties of novel biodegradable copoly(amino acid)s based on 6-aminocaproic acid and L-proline were analyzed in this article. The cytotoxicity of the copolymer films was tested in vitro using human embryonic kidney (HEK) 293 cells. The cell proliferation, cell cycle, cell apoptosis, and hemolysis of the polymers were also investigated. No significant cytotoxic response was detected statistically by cytotoxicity assay, and the results of cell apoptosis and cell cycle showed that there were no statistically significant differences in them. Generally, the cells spread and grew well on polymer film. Meanwhile, the extent of hemolysis on the polymers was acceptable. Evaluation of cytotoxicity by cell cycle and apoptosis as a supplementary assay is correspondingly discussed in this article.
Zhang
Weipeng
W
School of Materials Science and Engineering, State Key Laboratory for Mechanical Behavior of Materials, Xi'an Jiaotong University, West Xianning Road, Xi'an 710049, People's Republic of China. zwpchina@hotmail.com
Shao
Jianmin
J
D015119:Aminocaproic Acid / Q000737:chemistry*; D000818:Animals; D000933:Antifibrinolytic Agents / Q000737:chemistry; D017209:Apoptosis; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D002453:Cell Cycle; D002460:Cell Line; D049109:Cell Proliferation; D006801:Humans; D008422:Materials Testing; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry / Q000378:metabolism; D011392:Proline / Q000737:chemistry*; D011817:Rabbits
D000933:Antifibrinolytic Agents; D001672:Biocompatible Materials; D011108:Polymers; D011392:Proline; D015119:Aminocaproic Acid