title: Acute exacerbation impairs endothelial function in patients with chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  The effect of acute exacerbation of chronic obstructive pulmonary disease (COPD) on brachial artery flow-mediated dilation (FMD) has not been examined. The aim of this study was to assess the endothelial function of COPD patients during acute exacerbations.
  
  
  METHODS
  The study included 30 consecutive patients (8 women, 22 men; mean age 64.2+/-10.9 years) who experienced acute exacerbation of COPD, defined according to the Anthonisen criteria (increased dyspnea, sputum, and sputum purulence). All patients received the same antibiotic and bronchodilator treatment. Endothelial function was assessed by brachial artery ultrasonography within the first 48 hours and after complete resolution of exacerbation symptoms. Flow-mediated dilation was defined as both the maximum absolute and maximum percentage changes in the vessel diameter during reactive hyperemia. The results were compared with those of 20 age-and sex-matched controls without COPD.
  
  
  RESULTS
  The patient and control groups were similar in terms of age, gender, hypertension, diabetes, hyperlipidemia, coronary artery disease, heart rate, and blood pressure. Parameters of FMD during acute exacerbation were significantly lower than those obtained after recovery (absolute change: 0.23+/-0.12 mm vs. 0.38+/-0.17 mm, p<0.001; percentage change: 6.44+/-3.99% vs. 10.42+/-4.86%, p<0.001) and than those of the control group (absolute change: 0.36+/-0.13 mm, p=0.001; percentage change: 9.77+/-3.83%, p=0.003). Flow-mediated dilation increased significantly after recovery, yielding similar values to those of the controls. Improvements in FMD were significant in both sexes.
  
  
  CONCLUSIONS
  Acute COPD exacerbation is associated with worsening endothelial function, increasing the risk for cardiovascular morbidity.
authors.affiliation: Department of Cardiology, Medicine Faculty of Marmara University, Istanbul, Turkey. besteozben@yahoo.com
authors.forename: Beste
authors.initials: B
authors.lastname: Ozben
authors.forename: Emel
authors.initials: E
authors.lastname: Eryüksel
authors.forename: Azra Meryem
authors.initials: AM
authors.lastname: Tanrikulu
authors.forename: Nurdan
authors.initials: N
authors.lastname: Papila-Topal
authors.forename: Turgay
authors.initials: T
authors.lastname: Celikel
authors.forename: Yelda
authors.initials: Y
authors.lastname: Başaran
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000503:physiopathology*; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012016:Reference Values; D014463:Ultrasonography; D014664:Vasodilation; D014797:Vital Capacity