title: Multi-institutional study of risk factors of liver metastasis from colorectal cancer: correlation with CD10 expression.
abstract: BACKGROUND
  The risk factors for liver metastasis from colorectal cancer are still unclear. We therefore evaluated the relationships between various clinicopathological factors, including CD10 expression, liver metastasis, and survival, in patients with colorectal cancer.
  
  
  METHODS
  Clinicopathological data for 1,025 patients with stage II or III colorectal cancer who underwent curative surgery in four participating hospitals were collected and evaluated. Three pathologists examined focal dedifferentiation, venous invasion, and CD10 expression without knowledge of the clinical outcome.
  
  
  RESULTS
  Univariate analysis showed that pathological T (pT), pathological N (pN), venous invasion, focal dedifferentiation, and CD10 expression were significantly associated with liver metastasis. Multivariate analysis selected pT, pN, and CD10 expression as significant risk factors for liver metastasis. pT, pN and CD10 were also shown by univariate and multivariate analyses to be significantly associated with disease-free survival. The incidence of liver metastasis was 3% in pN0 patients with CD10-negative or pT2 or pT3 tumors and 28% in pN2 patients with CD10-positive or pT4 tumors.
  
  
  CONCLUSIONS
  CD10 expression is a significant risk factor for liver metastasis in patients with colorectal cancer and is correlated with prognosis. Patients with a high risk of liver metastasis can be selected on the basis of pT, pN, and CD10 expression.
authors.affiliation: Colorectal Surgery Division, National Cancer Center Hospital, 1-1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan. sfujita@ncc.go.jp
authors.forename: Shin
authors.initials: S
authors.lastname: Fujita
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Yao
authors.forename: Tadakazu
authors.initials: T
authors.lastname: Shimoda
authors.forename: Hideki
authors.initials: H
authors.lastname: Ueno
authors.forename: Takashi
authors.initials: T
authors.lastname: Hirai
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ohue
mesh_terms: D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D018572:Disease-Free Survival; D006801:Humans; D015994:Incidence; D008113:Liver Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000556:secondary*; D015999:Multivariate Analysis; D015260:Neprilysin / Q000378:metabolism*; D011379:Prognosis; D012307:Risk Factors
chemical_list: D015260:Neprilysin