title: Exercise-induced hormesis may help healthy aging.
abstract: Hormesis plays a critical role in producing some major benefits derived from physical exercise. However whether these known cellular mechanisms are applicable to ameliorate age-related deterioration of muscle function is not entirely clear. The present communication proposes that antioxidant adaptation, the peroxisome proliferator-activated receptor gamma coactivator (PGC)-1alpha activated mitochondrial biogenesis, and eccentric contraction-induced, cytokine-propelled muscle inflammation could be important redox-sensitive pathways by which exercise-induced disturbance in oxidant-antioxidant hemeostasis may serve as a heretic stimulus to promote adaptations that help healthy aging and improve the quality of life.
authors.affiliation: The Biodynamics Laboratory, Department of Kinesiology, University of Wisconsin-Madison, 2000 Observatory Drive, Madison, WI 53706, USA. ji@education.wisc.edu
authors.forename: Li Li
authors.initials: LL
authors.lastname: Ji
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Dickman
authors.forename: Chounghun
authors.initials: C
authors.lastname: Kang
authors.forename: Ryan
authors.initials: R
authors.lastname: Koenig