Biocatalysed concurrent production of enantioenriched compounds through parallel interconnected kinetic asymmetric transformations.
Parallel interconnected kinetic asymmetric transformations were performed in order to obtain enantioenriched derivatives starting from a set of racemic or prochiral compounds. Thus, in a one-pot reaction using two redox biocatalysts (a BVMO and an ADH) and a catalytic amount of cofactor that acts as a mediator, enantioenriched ketones, sulfoxides, and sec-alcohols were concurrently obtained in a strict parallel way, minimising the quantity of reagents employed. By selecting the appropriate biocatalysts, this methodology represents a potential tool for performing stereodivergent transformations.
Rioz-Martínez
Ana
A
Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, C/Julián Clavería 8, 33006, Oviedo, Spain.
Bisogno
Fabricio R
FR
Rodríguez
Cristina
C
de Gonzalo
Gonzalo
G
Lavandera
Iván
I
Torres Pazmiño
Daniel E
DE
Fraaije
Marco W
MW
Gotor
Vicente
V
D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D055162:Biocatalysis; D001711:Biotransformation; D003067:Coenzymes / Q000378:metabolism; D007202:Indicators and Reagents; D007700:Kinetics; D052196:Levilactobacillus brevis / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D046968:Thermoanaerobacter / Q000201:enzymology
D003067:Coenzymes; D007202:Indicators and Reagents; D006899:Mixed Function Oxygenases; D000426:Alcohol Dehydrogenase