Variants of the CD36 gene and metabolic syndrome in Boston Puerto Rican adults.
OBJECTIVE
Puerto Ricans experience a high prevalence of several chronic conditions, including metabolic syndrome. Genetic variants of the CD36 gene have been associated with metabolic syndrome. We aimed to determine the association between 6 single nucleotide polymorphisms (SNPs) for CD36 and metabolic syndrome and its components in Puerto Ricans (45-75 year) living in the Greater Boston area.


METHODS
Associations between each SNP, metabolic syndrome and its components were examined using multivariate logistic regression models. Haplotype trend regression analysis was used to determine associations between haplotypes and metabolic syndrome.


RESULTS
For two SNPs of CD36 (rs1049673 and rs3211931), homozygous subjects of the minor allele (G and T, respectively) were associated with a higher likelihood of metabolic syndrome (odds ratio (OR) (95% confidence interval (CI)): 1.89 (1.0, 3.5) and 1.77 (1.0, 3.1), respectively) relative to carriers of the major allele. Although CD36 haplotypes were not significantly associated with metabolic syndrome overall (global significance, P=0.23), one haplotype (G-C-C vs. C-C-C (reference haplotype)) was marginally associated (P=0.049).


CONCLUSIONS
SNPs of CD36 were associated with metabolic syndrome in Puerto Ricans. Prospective studies should further explore the role of CD36 variants in the development of this condition.
Noel
Sabrina E
SE
Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA), Tufts University, Boston, MA 02111, United States.
Lai
Chao-Qiang
CQ
Mattei
Josiemer
J
Parnell
Laurence D
LD
Ordovas
Jose M
JM
Tucker
Katherine L
KL
D000328:Adult; D001900:Boston / Q000453:epidemiology; D018955:CD36 Antigens / Q000235:genetics*; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011647:Puerto Rico / Q000208:ethnology
D018955:CD36 Antigens