title: Dietary fat modifications and blood pressure in subjects with the metabolic syndrome in the LIPGENE dietary intervention study.
abstract: Hypertension is a key feature of the metabolic syndrome. Lifestyle and dietary changes may affect blood pressure (BP), but the knowledge of the effects of dietary fat modification in subjects with the metabolic syndrome is limited. The objective of the present study was to investigate the effect of an isoenergetic change in the quantity and quality of dietary fat on BP in subjects with the metabolic syndrome. In a 12-week European multi-centre, parallel, randomised controlled dietary intervention trial (LIPGENE), 486 subjects were assigned to one of the four diets distinct in fat quantity and quality: two high-fat diets rich in saturated fat or monounsaturated fat and two low-fat, high-complex carbohydrate diets with or without 1.2 g/d of very long-chain n-3 PUFA supplementation. There were no overall differences in systolic BP (SBP), diastolic BP or pulse pressure (PP) between the dietary groups after the intervention. The high-fat diet rich in saturated fat had minor unfavourable effects on SBP and PP in males.
authors.affiliation: Hormone Laboratory, Department of Clinical Endocrinology, Faculty of Medicine, Oslo University Hospital Aker, University of Oslo, Trondheimsveien 235, N-0514 Oslo, Norway. h.l.gulseth@medisin.uio.no
authors.forename: Hanne L
authors.initials: HL
authors.lastname: Gulseth
authors.forename: Ingrid M F
authors.initials: IM
authors.lastname: Gjelstad
authors.forename: Audrey C
authors.initials: AC
authors.lastname: Tierney
authors.forename: Danielle I
authors.initials: DI
authors.lastname: Shaw
authors.forename: Olfa
authors.initials: O
authors.lastname: Helal
authors.forename: Anneke M J V
authors.initials: AM
authors.lastname: Hees
authors.forename: Javier
authors.initials: J
authors.lastname: Delgado-Lista
authors.forename: Iwona
authors.initials: I
authors.lastname: Leszczynska-Golabek
authors.forename: Brita
authors.initials: B
authors.lastname: Karlström
authors.forename: Julie
authors.initials: J
authors.lastname: Lovegrove
authors.forename: Catherine
authors.initials: C
authors.lastname: Defoort
authors.forename: Ellen E
authors.initials: EE
authors.lastname: Blaak
authors.forename: Jose
authors.initials: J
authors.lastname: Lopez-Miranda
authors.forename: Aldona
authors.initials: A
authors.lastname: Dembinska-Kiec
authors.forename: Ulf
authors.initials: U
authors.lastname: Risérus
authors.forename: Helen M
authors.initials: HM
authors.lastname: Roche
authors.forename: Kåre I
authors.initials: KI
authors.lastname: Birkeland
authors.forename: Christian A
authors.initials: CA
authors.lastname: Drevon
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000494:pharmacology; D004041:Dietary Fats / Q000008:administration & dosage* / Q000145:classification / Q000494:pharmacology; D005227:Fatty Acids / Q000008:administration & dosage / Q000494:pharmacology; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage / Q000494:pharmacology; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism*; D008875:Middle Aged
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005227:Fatty Acids; D005229:Fatty Acids, Monounsaturated; D015525:Fatty Acids, Omega-3