title: Tissue Doppler echocardiography reveals distinct patterns of impaired myocardial velocities in different degrees of coronary artery disease.
abstract: Aim To determine how the left ventricular wall motion assessed by echocardiographic Tissue Doppler Imaging (TDI) is affected by increasing severity of coronary artery disease (CAD) among patients with stable angina pectoris and preserved ejection fraction.
  
  
  RESULTS
  This study comprises 82 patients with suspected angina pectoris, no previous cardiac history, and a normal ejection fraction, who were all examined with colour TDI prior to coronary angiography. Patients without significant stenoses (n = 35) constituted the control group and patients with significant stenoses (n = 47) were divided into three groups according to significant one-, two-, or three-vessel disease (n = 18, n = 14, and n = 15, respectively). Regional longitudinal peak systolic (s'), early (e'), and late diastolic (a') myocardial velocities were measured at six mitral annular sites and averaged to provide global estimates. Each patient with significant coronary disease was matched with a control of the same age, sex, body mass index, and status regarding diabetes and hypertension. Global systolic and diastolic performance by TDI (in terms of global s' and E/e') were negatively correlated to the number of vessels with significant stenoses (both P < 0.05). Regional analyses revealed that in one- and two-vessel disease, e' decreased significantly in the segments supplied by a stenotic artery. In patients with one-vessel disease, a' increased compensatorily with a significant reduction of e'/a'-ratio (0.86 +/- 0.24 vs. 1.00 +/- 0.28, P < 0.05). Both regional and global s' was significantly reduced in patients with three-vessels disease.
  
  
  CONCLUSIONS
  Colour TDI performed at rest in patients with stable angina and preserved ejection fraction reveals both diastolic and systolic dysfunction and the nature of the dysfunction depends on the extent of the CAD.
authors.affiliation: Department of Cardiology, Gentofte University Hospital, Post 4210, 65 Niels Andersens Vej, DK-2900 Hellerup, Copenhagen, Denmark. klewser@gmail.com
authors.forename: Soren
authors.initials: S
authors.lastname: Hoffmann
authors.forename: Rasmus
authors.initials: R
authors.lastname: Mogelvang
authors.forename: Niels Thue
authors.initials: NT
authors.lastname: Olsen
authors.forename: Peter
authors.initials: P
authors.lastname: Sogaard
authors.forename: Thomas
authors.initials: T
authors.lastname: Fritz-Hansen
authors.forename: Jan
authors.initials: J
authors.lastname: Bech
authors.forename: Soren
authors.initials: S
authors.lastname: Galatius
authors.forename: Jan Kyst
authors.initials: JK
authors.lastname: Madsen
authors.forename: Jan Skov
authors.initials: JS
authors.lastname: Jensen
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000473:pathology; D001783:Blood Flow Velocity; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging* / Q000473:pathology; D003971:Diastole; D015150:Echocardiography, Doppler / Q000295:instrumentation* / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D012720:Severity of Illness Index; D013318:Stroke Volume; D013599:Systole; D016277:Ventricular Function, Left