The two pathways for effective orthogonal protection of L-ornithine, for amino acylation of 5'-O-pivaloyl nucleosides, describe the general and important role for the successful imitation, during the model substrates for the ribosomal mimic reaction.
Bz(NO(2))-Orn(Boc)-OCH(2)CN was synthesized as an amino acid component with effective and successful orthogonal protection for amino acylation of 5'-O-Pivaloyl nucleosides and preparation of substrates for model ribosome reactions. The synthesis was carried out using suitable combinations of the methods of peptide synthesis and modification of amino acids.
Bayryamov
Stanislav G
SG
Laboratory of Biocatalysis, Institute of Organic Chemistry, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria. stanislav_bayryamov@abv.bg
Vassilev
Nikolay G
NG
Petkov
Dimiter D
DD
D000215:Acylation; D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D009952:Ornithine / Q000737:chemistry*; D012270:Ribosomes
D009952:Ornithine; D000241:Adenosine