title: Correlation between insulin resistance and white matter lesions among non-diabetic patients with ischemic stroke.
abstract: OBJECTIVE
  We investigated whether a correlation exists between insulin resistance and the severity of cerebral white matter lesions among non-diabetic patients with ischemic stroke.
  
  
  METHODS
  The subjects were 105 consecutive patients without diabetes who were hospitalized due to non-cardioembolic stroke. The insulin resistance was evaluated by a homeostasis model assessment of insulin resistance (HOMA-IR). The degrees of periventricular hyperintensity (PVH) and deep and subcortical white matter hyperintensity (DSWMH) were evaluated by the brain MRI. The HOMA-IR values >or=2.5 were indicative of the insulin resistance.
  
  
  RESULTS
  The presence of PVH and DSWMH were 86.7 and 83.8%, respectively. The ratio of insulin resistance increased with higher grades of PVH and DSWMH. The HOMA-IR level in grade 3 PVH was significantly higher than those in grades 0 and 1. The HOMA-IR level in grade 3 DSWMH was significantly higher than those in grades 0-2. Multiple linear regression analysis showed that HOMA-IR was significantly associated with PVH or DSWMH.
  
  
  CONCLUSIONS
  It was found that insulin resistance correlated with white matter lesions among non-diabetic patients with non-cardiogenic ischemic stroke.
authors.affiliation: Department of Internal Medicine, Division of Neurology, Nephrology, and Rheumatology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan. katumata@js3.so-net.ne.jp
authors.forename: Toshiya
authors.initials: T
authors.lastname: Katsumata
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Otori
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: Seiji
authors.initials: S
authors.lastname: Okubo
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nishiyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nagayama
authors.forename: Masayuki
authors.initials: M
authors.lastname: Ueda
authors.forename: Koichi
authors.initials: K
authors.lastname: Utsumi
authors.forename: Mineo
authors.initials: M
authors.lastname: Yamazaki
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Komaba
authors.forename: Ken-Ichiro
authors.initials: K
authors.lastname: Katsura
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Katayama
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000378:metabolism / Q000473:pathology*; D020521:Stroke / Q000378:metabolism / Q000473:pathology*