Novel epothilone lactones by an unusual diversion of the Grubbs' metathesis reaction.
An unusual reaction with Grubbs' catalyst during the synthesis of bridged epothilones yielded five-membered internal lactones instead of the expected metathesis products. Three of the lactones have activities comparable to epothilone D.
Chen
Qiao-Hong
QH
Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Ganesh
Thota
T
Jiang
Yi
Y
Banerjee
Abhijit
A
Sharma
Shubhada
S
Bane
Susan
S
Snyder
James P
JP
Kingston
David G I
DG
D003500:Cyclization; D034261:Epothilones / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular
D034261:Epothilones; D007783:Lactones