title: Maternal plasma P-selectin at 11 to 13 weeks of gestation in hypertensive disorders of pregnancy.
abstract: OBJECTIVE
  To determine if development of preeclampsia is preceded by altered maternal plasma P-selectin and if the levels are related with uterine artery pulsatility index.
  
  
  METHODS
  Plasma P-selectin and uterine artery pulsatility index were measured at 11-13 weeks in 121 cases that subsequently developed preeclampsia, 87 cases that developed gestational hypertension and 208 unaffected controls.
  
  
  RESULTS
  In the preeclampsia group the median multiple of the median in controls (MoM) P-selectin and uterine artery PI were significantly increased (1.2 MoM and 1.3 MoM). There was no significant association between P-selectin and uterine artery pulsatility index in either the preeclampsia or control group.
  
  
  CONCLUSIONS
  In pregnancies that develop preeclampsia there is evidence of platelet activation from the first trimester. However, there is no direct link between the degree of impaired placentation and platelet activation.
authors.affiliation: Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
authors.forename: Ranjit
authors.initials: R
authors.lastname: Akolekar
authors.forename: Alina
authors.initials: A
authors.lastname: Veduta
authors.forename: Ryoko
authors.initials: R
authors.lastname: Minekawa
authors.forename: Teodora
authors.initials: T
authors.lastname: Chelemen
authors.forename: Kypros H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D019007:P-Selectin / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D011446:Prospective Studies; D011673:Pulsatile Flow / Q000502:physiology; D014463:Ultrasonography; D055988:Uterine Artery / Q000000981:diagnostic imaging / Q000503:physiopathology
chemical_list: D019007:P-Selectin