Glycinergic interneurons in the respiratory network of the rhythmic slice preparation.
The neuronal network in the pre-Bötzinger Complex is the key element of respiratory rhythm generation. Isolated in a slice preparation, the pre-Bötzinger Complex network is still able to generate its inspiratory activity. Although the mechanism of rhythm generation in principle relies on glutamatergic neurons, interestingly we found that glycinergic neurons represent a major portion of all inspiratory neurons in the slice preparation.
Winter
Stefan M
SM
Abt. Neuro- und Sinnesphysiologie und DFG Forschungszentrum für Molekularphysiologie des Gehirns, Zentrum Physiologie und Pathophysiologie, Georg-August-Universität, 37073 Göttingen, Germany. shuelsm2@uni-goettingen.de
Fresemann
Jens
J
Schnell
Christian
C
Oku
Yoshitaka
Y
Hirrlinger
Johannes
J
Hülsmann
Swen
S
D000818:Animals; D055724:Electrophysiological Phenomena; D005998:Glycine / Q000378:metabolism*; D051379:Mice; D009415:Nerve Net / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D010507:Periodicity; D018040:Receptors, Neurokinin-1 / Q000378:metabolism; D015656:Respiratory Mechanics / Q000502:physiology*
D018040:Receptors, Neurokinin-1; D005998:Glycine