Exploring the antiperoxidative potential of morin on cyclophosphamide and flutamide-induced lipid peroxidation and changes in cholesterol profile in rabbit model.
Considering drug-induced lipid peroxidation as a possible mediator of drug-induced toxicity and exploiting the free radical scavenging action of antioxidants, the present study was designed to evaluate the antiperoxidative potential of morin on cyclophosphamide/flutamide-induced lipid peroxidation and also to evaluate the effect of morin on cyclophosphamide/flutamide-induced changes in cholesterol content in rabbit blood sample. This evaluation was done by measuring the malondialdehyde (MDA), reduced glutathione (GSH), 4-hydroxy-2-nonenal (4-HNE) and nitric oxide (NO) content of blood samples as markers of lipid peroxidation. In the cholesterol profile total cholesterol and high density lipoprotein cholesterol content of rabbit blood was determined. The study reveals the lipid peroxidation induction capacity of cyclophosphamide/flutamide and the antiperoxidative potential of morin on cyclophosphamide/flutamide-induced lipid peroxidation. It was also observed that morin has protective effect on cyclophosphamide/flutamide-induced changes in cholesterol content.
Ray
Supratim
S
Division of Pharmaceutical Chemistry, Dr. B C Roy College of Pharmacy & Allied Health Sciences, Bidhannagar, Durgapur 713 206, India. supratimray_in@yahoo.co.in
Chowdhury
Partha
P
Pandit
Bibhas
B
Ray
Sarbani Dey
SD
Das
Sumit
S
D000447:Aldehydes / Q000097:blood; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D003520:Cyclophosphamide / Q000633:toxicity*; D005419:Flavonoids / Q000494:pharmacology*; D005485:Flutamide / Q000633:toxicity*; D005978:Glutathione / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D023421:Models, Animal; D009569:Nitric Oxide / Q000097:blood; D016877:Oxidants / Q000633:toxicity*; D011817:Rabbits; D047309:Flavones
D000447:Aldehydes; D000970:Antineoplastic Agents; D000975:Antioxidants; D015415:Biomarkers; D002784:Cholesterol; D008076:Cholesterol, HDL; D003520:Cyclophosphamide; D005419:Flavonoids; D005485:Flutamide; D005978:Glutathione; D008315:Malondialdehyde; D009569:Nitric Oxide; D016877:Oxidants; C008548:morin; D047309:Flavones; C027576:4-hydroxy-2-nonenal