title: Immunohistochemical expression of epidermal growth factor receptor in breast cancer.
abstract: BACKGROUND
  Molecular-targeting drugs able to treat breast cancer expressing epidermal growth factor receptor (EGFR) would be clinically valuable. The aim of the current study was to determine the further significance of immunohistochemical expression of EGFR in breast cancer.
  
  
  METHODS
  The immunohistochemical expression of EGFR was examined in 37 women with breast cancer who had been treated with surgical resection. Relationship of EGFR expression and clinicopathological characteristics was investigated.
  
  
  RESULTS
  EGFR expression proved to be comparatively more frequent among triple-negative (estrogen receptor negative, progesterone receptor negative, and human epidermal growth factor receptor 2 negative) breast cancers (P = 0.067).
  
  
  CONCLUSIONS
  Knowledge of a patient's immunohistochemical EGFR expression, which could be one of the key molecular findings related to molecular-targeting therapy, might be useful information to treat triple-negative breast cancer.
authors.affiliation: Department of Surgery, Fukuoka Higashi Medical Center, 1-1-1 Chidori, Koga, Japan. paper7777@yahoo.co.jp
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Nozoe
authors.forename: Emiko
authors.initials: E
authors.lastname: Mori
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Iguchi
authors.forename: Akinori
authors.initials: A
authors.lastname: Egashira
authors.forename: Eisuke
authors.initials: E
authors.lastname: Adachi
authors.forename: Akito
authors.initials: A
authors.lastname: Matsukuma
authors.forename: Takahiro
authors.initials: T
authors.lastname: Ezaki
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D002293:Adenocarcinoma, Scirrhous / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D002291:Carcinoma, Papillary / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D066246:ErbB Receptors / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008875:Middle Aged; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
chemical_list: D066246:ErbB Receptors; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C512478:EGFR protein, human