title: Molecular detection and genetic diversity of norovirus genogroup IV: a yearlong monitoring of sewage throughout Italy.
abstract: Noroviruses cause acute viral gastroenteritis worldwide. They are classified in five genogroups, of which GI, GII, and GIV infect humans. Little information is available on the prevalence and clinical effects of GIV noroviruses. We conducted a large-scale molecular-epidemiological investigation, a yearlong monitoring of 11 wastewater treatment plants throughout Italy, with the aim of studying the circulation of GIV NoV, as well as its genetic diversity. Eight percent of samples tested positive, and sequence analysis showed a considerable degree of genetic variability. These results imply the need for further studies to elucidate the role of this virus as a gastroenteritis-causing pathogen.
authors.affiliation: Department of Environment and Primary Prevention, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy. giuseppina.larosa@iss.it
authors.forename: Giuseppina
authors.initials: G
authors.lastname: La Rosa
authors.forename: Marcello
authors.initials: M
authors.lastname: Iaconelli
authors.forename: Manoochehr
authors.initials: M
authors.lastname: Pourshaban
authors.forename: Marta
authors.initials: M
authors.lastname: Fratini
authors.forename: Michele
authors.initials: M
authors.lastname: Muscillo
mesh_terms: D016000:Cluster Analysis; D014644:Genetic Variation; D005838:Genotype; D007558:Italy; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D029322:Norovirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D010802:Phylogeny; D015995:Prevalence; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D012722:Sewage / Q000821:virology*
chemical_list: D012722:Sewage