title: A hybrid multi-distance phase and broadband spatially resolved spectrometer and algorithm for resolving absolute concentrations of chromophores in the near-infrared light spectrum.
abstract: For resolving absolute concentration of tissue chromophores in the human adult brain with near-infrared spectroscopy it is necessary to calculate the light scattering and absorption, at multiple wavelengths with some depth resolution. To achieve this we propose an instrumentation configuration that combines multi-distance frequency and broadband spectrometers to quantify chromophores in turbid media by using a hybrid spatially resolved algorithm. Preliminary results in solid phantoms as well as liquid dynamic homogeneous and inhomogeneous phantoms and in-vivo muscle measurements showed encouraging results.
authors.affiliation: Biomedical Optics Research Laboratory, Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK. iliastac@medphys.ucl.ac.uk
authors.forename: Ilias
authors.initials: I
authors.lastname: Tachtsidis
authors.forename: Lei
authors.initials: L
authors.lastname: Gao
authors.forename: Terence S
authors.initials: TS
authors.lastname: Leung
authors.forename: Matthias
authors.initials: M
authors.lastname: Kohl-Bareis
authors.forename: Chris E
authors.initials: CE
authors.lastname: Cooper
authors.forename: Clare E
authors.initials: CE
authors.lastname: Elwell
mesh_terms: D000042:Absorption; D000465:Algorithms; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D009132:Muscles / Q000502:physiology; D010100:Oxygen / Q000378:metabolism; D019047:Phantoms, Imaging; D010860:Pigments, Biological / Q000032:analysis*; D012146:Rest / Q000502:physiology; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation* / Q000379:methods*; D055815:Young Adult
chemical_list: D006454:Hemoglobins; D010860:Pigments, Biological; D010100:Oxygen