title: Overview of formation of G-quadruplex structures.
abstract: There are many structures that can be adopted by nucleic acids other than the Watson-Crick duplex. In particular, a noncanonical four-stranded topology, called a G-quadruplex, is of great interest because of its roles in key biological processes such as the maintenance of telomeres and regulation of gene transcription. This review describes the condition for forming the G-quadruplex structure, G-quadruplex-forming sequences, and methods for studying the structures.
authors.affiliation: Kyoto University, Kyoto, Japan.
authors.forename: Yuta
authors.initials: Y
authors.lastname: Sannohe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sugiyama
mesh_terms: D001483:Base Sequence; D054856:G-Quadruplexes; D009696:Nucleic Acids / Q000737:chemistry* / Q000235:genetics
chemical_list: D009696:Nucleic Acids