Magnetic deposition of aerosols composed of aggregated superparamagnetic nanoparticles.
OBJECTIVE
The deposition of magnetic particles was examined for the possibility of further enhancing the selectivity of inhalation drug administration for the treatment of lung cancer.


METHODS
Superparamagnetic magnetite nanoparticles were prepared and ultrasonically atomized, dried, and passed through glass tubes in the presence and absence of a wedge-shaped permanent magnet. The change in the outlet aerosol size distribution due to magnetic deposition under various well-defined aerodynamic conditions and a measured magnetic field was determined by an aerodynamic particle sizer. In addition, computational fluid dynamics (CFD) simulations of magnetic aerosol transport and deposition were conducted.


RESULTS
The deposition fraction increased nearly linearly with particle diameter and was greater with lower air flow rates. The effect of tube diameter was complicated but well described by CFD simulations, as was the effect of particle size and air flow rate.


CONCLUSIONS
The descriptive power of CFD simulations was demonstrated in the in vitro deposition of magnetic aerosol particles. This suggests that CFD simulations can potentially be used in future studies to design systems for selective drug delivery in vivo as a function of magnetic properties, aerosol characteristics, and respiratory physiology.
Xie
Yuanyuan
Y
Department of Pharmaceutics, University Of Minnesota, Minneapolis, Minnesota, USA.
Zeng
Pengyun
P
Siegel
Ronald A
RA
Wiedmann
Timothy Scott
TS
Hammer
Bruce E
BE
Longest
P Worth
PW
D000280:Administration, Inhalation; D000336:Aerosols; D000465:Algorithms; D003198:Computer Simulation; D016503:Drug Delivery Systems; D004574:Electromagnetic Fields; D052203:Ferrosoferric Oxide / Q000008:administration & dosage* / Q000737:chemistry*; D008280:Magnetics; D015233:Models, Statistical; D053758:Nanoparticles / Q000008:administration & dosage*; D010316:Particle Size
D000336:Aerosols; D052203:Ferrosoferric Oxide