title: Liposomes incorporating sodium deoxycholate for hexamethylmelamine (HMM) oral delivery: development, characterization, and in vivo evaluation.
abstract: Liposomes incorporating sodium deoxycholate (NaDC) were prepared by the method of reverse phase evaporation and used for drug delivery by the oral route. Hexamethylmelamine (HMM), an anti-tumor agent, was chosen as a model drug and encapsulated into liposomes incorporating NaDC (NaDC-Lip). Several properties of NaDC-Lip containing HMM (HMM NaDC-Lip), such as particle size, entrapment efficiency, pinacyanol chloride (PIN) spectral characteristics with various molar ratio of NaDC/PC, as well as the vesicle stability measurements with calcein were evaluated. In vivo, the area under the plasma concentration-time curve obtained from the pharmacokinetics study of HMM NaDC-Lip was found to be approximately 9.76- and 1.21-fold higher than that of HMM solution and HMM Lip, respectively, indicating that NaDC-Lip can be used as a potential carrier for oral drug administration.
authors.affiliation: Department of Pharmaceutics, Shenyang Pharmaceutical University, Shenyang, PR China.
authors.forename: Jukui
authors.initials: J
authors.lastname: Sun
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Deng
authors.forename: Siling
authors.initials: S
authors.lastname: Wang
authors.forename: Jinna
authors.initials: J
authors.lastname: Cao
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Gao
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Dong
mesh_terms: D000284:Administration, Oral; D006585:Altretamine / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002232:Carbocyanines / Q000737:chemistry; D002784:Cholesterol / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D003840:Deoxycholic Acid / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D004355:Drug Stability; D005260:Female; D005452:Fluoresceins / Q000737:chemistry; D008055:Lipids / Q000737:chemistry; D008081:Liposomes / Q000737:chemistry*; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar; D013056:Spectrophotometry, Ultraviolet
chemical_list: D018906:Antineoplastic Agents, Alkylating; D002232:Carbocyanines; D004337:Drug Carriers; D005452:Fluoresceins; D008055:Lipids; D008081:Liposomes; D003840:Deoxycholic Acid; C019071:quinaldine blue; D002784:Cholesterol; D006585:Altretamine; C007740:fluorexon