Targeting of nanoparticles: folate receptor.
Nanoparticulate medicines offer the advantage of allowing delivery of large quantities of unmodified drug within the same particle. Nanoparticle uptake by cancer cells can, however, be compromised due to the large size and hydrophilicity of the particle. To circumvent cell penetration problems and simultaneously improve tumor specificity, nanoparticulate medicines have been linked to targeting ligands that bind to malignant cell surfaces and enter cells by receptor-mediated endocytosis. In this chapter, we summarize multiple methods for delivering nanoparticles into cancer cells by folate receptor-mediated endocytosis, devoting special emphasis to folate-targeted liposomes. Folate receptor-mediated endocytosis has emerged as an attractive strategy for nanoparticle delivery due to both overexpression of the folate receptor on cancer cells and the rapid internalization of the receptor by receptor-mediated endocytosis.
Kularatne
Sumith A
SA
Department of Chemistry and Purdue Cancer Center, Purdue University, West Lafayette, IN, USA.
Low
Philip S
PS
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D045744:Cell Line, Tumor; D003952:Diagnostic Imaging; D016503:Drug Delivery Systems / Q000379:methods*; D005260:Female; D058973:Folate Receptors, GPI-Anchored; D005492:Folic Acid / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D050997:Nanomedicine / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D009369:Neoplasms / Q000175:diagnosis; D010714:Phosphatidylethanolamines / Q000138:chemical synthesis / Q000737:chemistry; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry; D011622:Pterins / Q000138:chemical synthesis / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000378:metabolism*
C519184:1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000); D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D010714:Phosphatidylethanolamines; D011622:Pterins; D011956:Receptors, Cell Surface; D011092:Polyethylene Glycols; C005584:pteroic acid; D005492:Folic Acid