title: Sex differences in alpha-adrenergic support of blood pressure.
abstract: We tested whether the inter-individual variability in alpha-adrenergic support of blood pressure plays a critical role in the sex differences in tonic support of blood pressure by the autonomic nervous system. Blockade of the alpha-adrenergic receptors was achieved via phentolamine and showed a smaller (P < 0.05) decrease in blood pressure in women compared to men, implying that alpha-adrenergic support of blood pressure is less in women than in men.
authors.affiliation: Department of Anesthesiology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
authors.forename: Judith A M
authors.initials: JA
authors.lastname: Schmitt
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Joyner
authors.forename: Nisha
authors.initials: N
authors.lastname: Charkoudian
authors.forename: B Gunnar
authors.initials: BG
authors.lastname: Wallin
authors.forename: Emma C
authors.initials: EC
authors.lastname: Hart
mesh_terms: D018663:Adrenergic Agents / Q000494:pharmacology*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D012737:Sex Factors
chemical_list: D018663:Adrenergic Agents; D010646:Phentolamine