Discovery and SAR exploration of N-aryl-N-(3-aryl-1,2,4-oxadiazol-5-yl)amines as potential therapeutic agents for prostate cancer.
A new chemical series of antiproliferative compounds was identified via high-throughput screening on DU-145 human prostate carcinoma cell line (hit compound potency - 5.7 microM). Exploration of the two peripheral diversity vectors of the hit molecule in a hit-targeted library and testing of the resulting compounds led to SAR generalizations and identification of the 'best' pharmacophoric moieties. The latter were merged in a single compound that exhibited a 200-fold better potency than the original hit compound. Specific cancer cell cytotoxicity was confirmed for the most potent compounds.
Krasavin
Mikhail
M
Department of Medicinal Chemistry, Chemical Diversity Research Institute, Khimki, Moscow Region, Russian Federation.
Rufanov
Konstantin A
KA
Sosnov
Andrey V
AV
Karapetian
Ruben
R
Godovykh
Elena
E
Soldatkina
Olga
O
Lavrovsky
Yan
Y
Gakh
Andrei A
AA