Overweight and obesity negatively affect the outcomes of ovarian stimulation and in vitro fertilisation: a cohort study of 2628 Chinese women.
OBJECTIVE
To explore the effects of overweight and obesity on the outcomes of in vitro fertilisation (IVF) in Chinese infertile patients.


METHODS
A retrospective cohort study was carried out in 2222 normal weight (18.5 <or= BMI < 25), 379 overweight (25 <or= BMI < 30) and 27 obese (BMI >or= 30) women who underwent their first IVF cycles between 2002 and 2008. Cycle characteristics and IVF outcomes were analysed.


RESULTS
Obese women required significantly higher dose of rFSH (3272 IU vs. 2587 IU, p < 0.001) and days of stimulation (11.89 +/- 4.57 vs. 10.42 +/- 2.03, p < 0.001), but exhibited less oocytes retrieved and significantly lower fertilisation rate (54.1% vs. 61.1%, p < 0.001) than normal weight women. Compared with normal weight women, overweight women displayed significantly less oocytes retrieved (12.98 +/- 6.91 vs. 14.49 +/- 7.96, p < 0.001), lower fertilisation rate (60.8 +/- 23.3 vs. 61.1 +/- 23.0, p < 0.001), less cleavaged embryos (7.55 +/- 4.86 vs. 8.67 +/- 5.90, p < 0.001), less high-grade embryos (4.65 +/- 3.96 vs. 5.59 +/- 4.81, p < 0.001) and cryopreserved embryos (4.44 +/- 4.55 vs. 5.49 +/- 5.55, p < 0.001). All parameters of pregnancy outcomes, including pregnancy rate, miscarriage rate and live birth rate, were comparable among three groups.


CONCLUSIONS
Overweight and obesity are related with impared ovarian response, and negatively affect the outcomes of IVF.
Zhang
Dan
D
Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Zhu
Yimin
Y
Gao
Huijuan
H
Zhou
Biao
B
Zhang
Runju
R
Wang
Tingting
T
Ding
Guolian
G
Qu
Fan
F
Huang
Hefeng
H
Lu
Xiue
X
D000328:Adult; D015992:Body Mass Index; D002681:China; D015331:Cohort Studies; D015925:Cryopreservation; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D006801:Humans; D007246:Infertility / Q000628:therapy*; D009765:Obesity / Q000150:complications*; D009865:Oocytes; D050177:Overweight / Q000150:complications*; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011256:Pregnancy Outcome; D011994:Recombinant Proteins / Q000008:administration & dosage; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D020858:Tissue and Organ Harvesting; D016896:Treatment Outcome; D017329:Triptorelin Pamoate / Q000008:administration & dosage
D011994:Recombinant Proteins; D017329:Triptorelin Pamoate; D005640:Follicle Stimulating Hormone