title: Synthesis and fluorescence of the new environment-sensitive fluorophore 6-chloro-2,3-naphthalimide derivative.
abstract: Convenient and efficient synthesis of a new environmentally sensitive chlorine-substituted 2,3-naphthalimide-based fluorophore is reported. Benzotriazole carboxyl group activation of the 6-chloro-fluorophore enabled quick labeling of free and Fmoc-protected amino acids. The photophysical properties of the compounds obtained include high quantum yields in solvents of different polarity: water, methanol, acetonitrile and hexane.
authors.affiliation: Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
authors.forename: Alan R
authors.initials: AR
authors.lastname: Katritzky
authors.forename: Sevil
authors.initials: S
authors.lastname: Ozcan
authors.forename: Ekaterina
authors.initials: E
authors.lastname: Todadze
mesh_terms: D000042:Absorption; D000596:Amino Acids / Q000378:metabolism; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D053644:Naphthalimides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D055668:Photochemical Processes; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013194:Staining and Labeling
chemical_list: C549828:2-(6-chloro-1,3-dioxo-1H-benzo(f)isoindol-2(3H)-yl)acetic acid; D000596:Amino Acids; D005456:Fluorescent Dyes; D053644:Naphthalimides