Control of metabolism and signaling of simple bioactive sphingolipids: Implications in disease.
Simple bioactive sphingolipids include ceramide, sphingosine and their phosphorylated forms sphingosine 1-phosphate and ceramide 1-phosphate. These molecules are crucial regulators of cell functions. In particular, they play important roles in the regulation of angiogenesis, apoptosis, cell proliferation, differentiation, migration, and inflammation. Decoding the mechanisms by which these cellular functions are regulated requires detailed understanding of the signaling pathways that are implicated in these processes. Most importantly, the development of inhibitors of the enzymes involved in their metabolism may be crucial for establishing new therapeutic strategies for treatment of disease.
Gangoiti
Patricia
P
Department of Biochemistry and Molecular Biology, Faculty of Science and Technology, University of the Basque Country (UPV/EHU), Bilbao, Spain.
Camacho
Luz
L
Arana
Lide
L
Ouro
Alberto
A
Granado
Maria H
MH
Brizuela
Leyre
L
Casas
Josefina
J
Fabriás
Gemma
G
Abad
José Luis
JL
Delgado
Antonio
A
Gómez-Muñoz
Antonio
A
D000818:Animals; D055572:Ceramidases / Q000037:antagonists & inhibitors / Q000378:metabolism; D002518:Ceramides / Q000737:chemistry / Q000378:metabolism; D004194:Disease; D006801:Humans; D007249:Inflammation; D007527:Isoenzymes / Q000378:metabolism; D008246:Lysophospholipids / Q000737:chemistry / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D015394:Molecular Structure; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013107:Sphingolipids / Q000737:chemistry / Q000378:metabolism*; D013110:Sphingosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism; D000099157:Sphingosine Kinase
D055572:Ceramidases; D002518:Ceramides; D007527:Isoenzymes; D008246:Lysophospholipids; D017853:Phosphotransferases (Alcohol Group Acceptor); D013107:Sphingolipids; D013110:Sphingosine; D000099157:Sphingosine Kinase; C065576:ceramide 1-phosphate; C060506:sphingosine 1-phosphate