title: Combined intravenous recombinant-tissular plasminogen activator and endovascular treatment of spontaneous occlusive internal carotid dissection with tandem intracranial artery occlusion.
abstract: Internal carotid artery (ICA) dissection with tandem internal carotid and middle cerebral artery occlusion may carry a poor prognosis even if intravenous recombinant-tissular plasminogen activator is administered. A better outcome may be expected with the combination of intravenous thrombolysis and endovascular methods (stenting and thromboaspiration). This procedure was performed in 3 patients who had concurrent ICA dissection and intracerebral occlusion. Endovascular treatment was feasible and safe. All our patients had a good clinical outcome. This potential effective approach may need further validation.
authors.affiliation: Hôpital Neurologique et Neurochirurgical P. Wertheimer, Lyon, France.
authors.forename: Alain
authors.initials: A
authors.lastname: Lekoubou
authors.forename: Tae-Hee
authors.initials: TH
authors.lastname: Cho
authors.forename: Norbert
authors.initials: N
authors.lastname: Nighoghossian
authors.forename: Vincent
authors.initials: V
authors.lastname: Kumako
authors.forename: Laurent
authors.initials: L
authors.lastname: Derex
authors.forename: Paul
authors.initials: P
authors.lastname: Trouillas
authors.forename: Francis
authors.initials: F
authors.lastname: Turjman
mesh_terms: D000328:Adult; D020215:Carotid Artery, Internal, Dissection / Q000150:complications / Q000628:therapy*; D002533:Cerebral Angiography; D002548:Cerebral Revascularization / Q000379:methods*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D004333:Drug Administration Routes; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000150:complications / Q000628:therapy*; D007275:Injections, Intravenous / Q000379:methods; D008297:Male; D015607:Stents; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator