title: Synthesis and biological evaluation of 3-aminopyrrolidine derivatives as CC chemokine receptor 2 antagonists.
abstract: Novel 3-aminopyrrolidine derivatives were synthesized and evaluated for their antagonistic activity against human chemokine receptor 2. Structure-activity studies on 3-aminopyrrolidine incorporating heteroatomic carbocycle moieties led to piperidine compound 19, and piperazine compounds 42, 47 and 49 as highly potent hCCR2 antagonists.
authors.affiliation: Yangji Chemicals, Gyeonggi Bio-Center, Suwon 443-766, Republic of Korea. srhnys@hwpharm.com
authors.forename: Jee Woong
authors.initials: JW
authors.lastname: Lim
authors.forename: Youna
authors.initials: Y
authors.lastname: Oh
authors.forename: Jong-Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Oak
authors.forename: Yongho
authors.initials: Y
authors.lastname: Na
authors.forename: Jung-Ok
authors.initials: JO
authors.lastname: Lee
authors.forename: Seung-Woo
authors.initials: SW
authors.lastname: Lee
authors.forename: Heeyeong
authors.initials: H
authors.lastname: Cho
authors.forename: Woo-Kyu
authors.initials: WK
authors.lastname: Park
authors.forename: Gildon
authors.initials: G
authors.lastname: Choi
authors.forename: Jongmin
authors.initials: J
authors.lastname: Kang
mesh_terms: D002460:Cell Line; D002633:Chemotaxis / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D011485:Protein Binding / Q000187:drug effects; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D054390:Receptors, CCR2 / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D011759:Pyrrolidines; D054390:Receptors, CCR2