Signaling by ROS drives inflammasome activation.
Inflammasomes are innate immune signaling pathways that sense pathogens and injury to direct the proteolytic maturation of inflammatory cytokines such as IL-1beta and IL-18. Among inflammasomes, the NLRP3/NALP3 inflammasome is the most studied. However, little is known on the molecular mechanisms that mediate its assembly and activation. Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation.
Martinon
Fabio
F
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115, USA. fmartino@hsph.harvard.edu
D000818:Animals; D002352:Carrier Proteins / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D046912:Multiprotein Complexes / Q000276:immunology*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D018384:Oxidative Stress / Q000276:immunology; D017382:Reactive Oxygen Species / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
D002352:Carrier Proteins; D046912:Multiprotein Complexes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; D017382:Reactive Oxygen Species