title: Modeling optimal intervention strategies for cholera.
abstract: While cholera has been a recognized disease for two centuries, there is no strategy for its effective control. We formulate a mathematical model to include essential components such as a hyperinfectious, short-lived bacterial state, a separate class for mild human infections, and waning disease immunity. A new result quantifies contributions to the basic reproductive number from multiple infectious classes. Using optimal control theory, parameter sensitivity analysis, and numerical simulations, a cost-effective balance of multiple intervention methods is compared for two endemic populations. Results provide a framework for designing cost-effective strategies for diseases with multiple intervention methods.
authors.affiliation: Department of Mathematics, University of Tennessee, Knoxville, TN 37996, USA. rmill48@lsu.edu
authors.forename: Rachael L
authors.initials: RL
authors.lastname: Miller Neilan
authors.forename: Elsa
authors.initials: E
authors.lastname: Schaefer
authors.forename: Holly
authors.initials: H
authors.lastname: Gaff
authors.forename: K Renee
authors.initials: KR
authors.lastname: Fister
authors.forename: Suzanne
authors.initials: S
authors.lastname: Lenhart
mesh_terms: D050936:Basic Reproduction Number; D002771:Cholera / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control; D003198:Computer Simulation; D004196:Disease Outbreaks / Q000517:prevention & control*; D006801:Humans; D018448:Models, Immunological; D014734:Vibrio cholerae / Q000276:immunology*