[The free radical oxidation and antioxidant defense systems as indicators of the activity of keratinocytic proliferation in psoriasis].
The free radical oxidation and antioxidant defense (AOD) systems in the keratinocyte cultures were studied in patients with psoriasis before and after the use of combinations of liposomal preparations. Hyperproliferation of keratinocytes was found to be attended by suppressed lipid peroxidation and high cell antioxidant activity. On the contrary, the liposomal combinations-induced suppression of cell proliferation was characterized by a drastic increase in prooxidant activity in reference to the AOD of epidermal keratinocyte cultures.
Grashin
R A
RA
Antonov
V G
VG
Karpishchenko
A I
AI
Khaĭrutdinov
V R
VR
D000975:Antioxidants / Q000378:metabolism*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004146:Dioxanes / Q000494:pharmacology; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D008081:Liposomes; D010084:Oxidation-Reduction; D010431:Pentoxifylline / Q000494:pharmacology; D011565:Psoriasis / Q000378:metabolism / Q000473:pathology*; D018038:Sodium Selenite / Q000494:pharmacology
D000975:Antioxidants; D004146:Dioxanes; D005609:Free Radicals; D008081:Liposomes; D018038:Sodium Selenite; D010431:Pentoxifylline; C009143:proroxan