Identification and assessment of permeability enhancing vehicles for transdermal delivery of glucosamine hydrochloride.
As an initial step to develop the transdermal delivery system of glucosamine hydrochloride (GL-HCl), the permeation study across the rat skin in vitro was performed to identify the most efficient vehicle with regard to the ability to deliver GL-HCl transdermally. The GL-HCl formulations such as o/w cream, liposome suspension, liposomal gel, and liquid crystalline vehicles were prepared and compared for transdermal flux of GL-HCl. The liquid crystalline vehicles were more effective in increasing the skin permeation of GL-HCl than o/w cream and liposomal vehicles. Of the liquid crystalline vehicles tested, the permeation enhancing ability of the cubic phase was greater than that of the hexagonal phase when the nanoparticle dispersion was used. The skin permeation enhancing ability of the cubic nanoparticles for GL-HCl was further increased by employing both oleic acid and polyethylene glycol 200. Therefore, the cubic liquid crystalline nanodispersion containing oleic acid and PEG 200 can provide a possibility of clinical application of transdermal GL-HCl.
Han
In Hee
IH
Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
Choi
Sung-Up
SU
Nam
Dae Young
DY
Park
Young Mi
YM
Kang
Myung Joo
MJ
Kang
Kyoung Hoon
KH
Kim
Yong Min
YM
Bae
Gunho
G
Oh
Il Young
IY
Park
Jong Hyeok
JH
Ye
Jin Soo
JS
Choi
Yoon Bae
YB
Kim
Duk Ki
DK
Lee
Jaehwi
J
Choi
Young Wook
YW
D000279:Administration, Cutaneous; D000818:Animals; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D016503:Drug Delivery Systems / Q000379:methods*; D005944:Glucosamine / Q000008:administration & dosage*; D019301:Oleic Acid / Q000008:administration & dosage*; D010539:Permeability / Q000187:drug effects*; D014677:Pharmaceutical Vehicles / Q000008:administration & dosage* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000008:administration & dosage; D051381:Rats; D017207:Rats, Sprague-Dawley; D012869:Skin Absorption / Q000187:drug effects
D014677:Pharmaceutical Vehicles; D019301:Oleic Acid; D011092:Polyethylene Glycols; D005944:Glucosamine