title: Severe metabolic acidosis secondary to coadministration of creatine and metformin, a case report.
abstract: It is known from studies in young athletes that creatine supplements have beneficial effects on muscular functional capacity, so it is being widely used as a performance-enhancing substance in both professional and amateur sports men and women. They are approved and considered relatively safe, but there have been a few case reports of renal dysfunction associated with their use. We present the case of a patient who developed acute renal failure and lactic acidosis while using creatine and metformin simultaneously.
authors.affiliation: Department of Emergency Medicine, Hazrat Rasool-e-Akram Hospital, Iran University of Medical Sciences and Health Services, Tehran, Iran.
authors.forename: Hossein
authors.initials: H
authors.lastname: Saidi
authors.forename: Mofidi
authors.initials: M
authors.lastname: Mani
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced*; D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D003401:Creatine / Q000008:administration & dosage / Q000009:adverse effects*; D003937:Diagnosis, Differential; D019587:Dietary Supplements / Q000009:adverse effects*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008687:Metformin / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin; D003401:Creatine