title: Gender differences in the correlation between symptom and radiographic severity in patients with knee osteoarthritis.
abstract: BACKGROUND
  The effects of gender on the relationship between symptom manifestations and radiographic grades of knee osteoarthritis are not well understood.
  
  
  OBJECTIVE
  We therefore determined the increments of symptom progression with regard to radiographic grades of knee osteoarthritis and asked if those increments differed by gender and whether symptom severity was differentially manifested by gender within the same grade.
  
  
  METHODS
  We recruited 660 community residents; 368 (56%) women and 292 (44%) men. The mean subject age was 71.5 years (range, 65-91 years). Severity of symptoms was measured using the WOMAC and SF-36 scales, and the radiographic severity using Kellgren-Lawrence grades. Incremental changes in WOMAC and SF-36 scores were compared between adjacent Kellgren-Lawrence grades separately in men and women, and in the overall population. We compared symptom severity between men and women with the same radiographic grade.
  
  
  RESULTS
  For the entire cohort, the mean incremental change in symptom severity was not gradual between the adjacent radiographic grades but was greater between Kellgren-Lawrence Grades 1 and 2 and Grades 2 and 3 than between Grades 0 and 1 or Grades 3 and 4. The patterns of incremental changes in symptom severity differed between men and women: women had more severe symptom progression between Kellgren-Lawrence Grades 2 and 3 and Grades 3 and 4 than men. Furthermore, women had worse mean WOMAC and SF-36 scores than men with the same radiographic grade of knee osteoarthritis.
  
  
  CONCLUSIONS
  These data suggest symptom progression is not gradual between adjacent radiographic grades, and for the same radiographic grade, symptoms are worse in women.
  
  
  METHODS
  Level III, diagnostic study. See Guidelines for Authors for a complete description of levels of evidence.
authors.affiliation: Joint Reconstruction Center, Seoul National University Bundang Hospital, 300 Gumidong, Bundangu, Seongnamsi, Gyunggido, 463-707, Korea.
authors.forename: Hyung Joon
authors.initials: HJ
authors.lastname: Cho
authors.forename: Chong Bum
authors.initials: CB
authors.lastname: Chang
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Yoo
authors.forename: Sung Ju
authors.initials: SJ
authors.lastname: Kim
authors.forename: Tae Kyun
authors.initials: TK
authors.lastname: Kim
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008297:Male; D020370:Osteoarthritis, Knee / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D010146:Pain; D011859:Radiography; D016059:Range of Motion, Articular; D012720:Severity of Illness Index; D012737:Sex Factors