title: [Randomized clinical trial with a inulin enriched cookie on risk cardiovascular factor in obese patients].
abstract: BACKGROUND
  Inulin is a prebiotic with potential benefit in cardiovascular risk factors. The aim of our work is to evaluate in obese patients the effect of a inulin enriched cookie on cardiovascular risk factors.
  
  
  METHODS
  34 patients were randomized in both branches: group I (inulin enriched cookie) Gullon SL(R) and group II (control cookie). Previous and after 1 month of the treatment, a nutritional and biochemical study was realized.
  
  
  RESULTS
  15 patients finished the procotol in each group. In group I, an increase in soluble fiber intake (inulin) was detected. In this group a significant decrease of total cholesterol (223.1 +/- 45.3 mg/dl vs 208.8 +/- 33.1 mg/dl; p < 0.05) and LDL cholesterol (142.9 +/- 39.2 mg/dl vs 131.4 +/- 28.6 mg/dl; p < 0.05) was reached. A non significant improvement in insulin levels and HOMA was detected in inulin-enriched cookie group, too. Anthropometric parameters did not change in both groups. The increase in soluble fiber intake did not produce any gastrointestinal adverse effect.
  
  
  CONCLUSIONS
  The increase of fiber intake (3 g of inulin) from an enriched cookie reduced LDL cholesterol levels in obese patients.
authors.affiliation: Instituto de Endocrinología y Nutrición, Facultad de Medicina, Universidad de Valladolid, Simancas, Valladolid, España. dadluis@yahoo.es
authors.forename: D A
authors.initials: DA
authors.lastname: de Luis
authors.forename: B
authors.initials: B
authors.lastname: de la Fuente
authors.forename: O
authors.initials: O
authors.lastname: Izaola
authors.forename: R
authors.initials: R
authors.lastname: Conde
authors.forename: S
authors.initials: S
authors.lastname: Gutiérrez
authors.forename: M
authors.initials: M
authors.lastname: Morillo
authors.forename: C
authors.initials: C
authors.lastname: Teba Torres
mesh_terms: D000328:Adult; D000368:Aged; D001835:Body Weight / Q000502:physiology; D002318:Cardiovascular Diseases / Q000178:diet therapy / Q000209:etiology* / Q000517:prevention & control*; D004043:Dietary Fiber / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007444:Inulin / Q000008:administration & dosage / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications* / Q000178:diet therapy / Q000453:epidemiology; D012307:Risk Factors
chemical_list: D004043:Dietary Fiber; D008055:Lipids; D007444:Inulin