Outcomes of total pelvic exenteration for colorectal cancer.
OBJECTIVE
Pelvic recurrence occurs in 4-33% of patients who have undergone a curative resection of primary rectal cancer and is thus a serious problem. However, the best treatment for primary rectal cancer remains unclear. In the present study was assessed the outcomes of total pelvic exenteration for colorectal cancer retrospectively.


METHODS
In the present study was investigated the medical charts of 25 patients who underwent total pelvic exenteration for primary colorectal cancer (n = 12) or postoperative local recurrence of colorectal cancer (n = 13) at the Department of Surgery (Division of Digestive Surgery) of the Kyoto Prefectural University of Medicine between the years 1997-2005.


RESULTS
The mean disease-free time interval between the first operation for primary colorectal cancer and total pelvic exenteration for the recurrence was 919 days (range, 203-3460 days). Total pelvic exenteration required a mean operation time of 940 minutes (range, 540-1395 minutes). The mean carcinoembryonic antigen (CEA) value was 25.5 ng/ml (range, 1-171.8 ng/ml). Five-year survival was achieved in 9 patients (36%) and inhospital death occurred in 3 patients (12%). The patients with curative resection survived significantly longer than the patients with non-curative resection.


CONCLUSIONS
When curative resection is achieved, total pelvic exenteration for colorectal cancer can result in long-term survival.
Nishio
Minoru
M
Department of Surgery and Regenerative Medicine, Division of Surgery and Physiology of the Digestive System, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi, Kamigyo-ku, Kyoto, Japan.
Sakakura
Chohei
C
Nagata
Tomoyuki
T
Miyashita
Atsushi
A
Hamada
Takuo
T
Ikoma
Hisashi
H
Kubota
Takeshi
T
Nakanishi
Masayoshi
M
Kimura
Akio
A
Ichikawa
Daisuke
D
Kikuchi
Syoujirou
S
Fujiwara
Hitoshi
H
Okamoto
Kazuma
K
Ochiai
Toshiya
T
Kokuba
Yukihito
Y
Taniguchi
Hiroki
H
Sonoyama
Teruhisa
T
Hagiwara
Akeo
A
Otsuji
Eigo
E
D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000401:mortality / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D010385:Pelvic Exenteration; D015996:Survival Rate; D016896:Treatment Outcome