title: [Effect of gastric bypass on the metabolic syndrome and on cardiovascular risk].
abstract: BACKGROUND
  Obesity is associated with increased morbimortality cardiovascular. Individual with metabolic syndrome (MS) are a high risk of developing cardiovascular disease (CVD). The aim of this study was to determine the prevalence of the MS in morbidly obese patients enrolling in a bariatric surgery program and to evaluate the impact of weigh loss induced by gastric bypass on the MS and on the predicted 10-year cardiovascular risk.
  
  
  METHODS
  We studied 46 morbidly obese patients who underwent laparoscopic gastric bypass and were followed for 2 years. MS was defined following the IDF 2005 criteria and the insulin resistance (IR) was calculated by using HOMA index. Risk assessment for estimating 10-year ECV risk was carried out according to Framingham score.
  
  
  RESULTS
  Before surgery, 67.2% of patients had IR and 60,9% met the definition of the MS. 17.3% of patients had an elevated cardiovascular risk category. 2 years after gastric bypass, the percentage of excess body weight lost was 72%. All patients restored their HOMA index and only 1 patient (3.6%) had MS. Resolution of hypertension, disglucemia and dislipemia has been observed in 85%, 93.8% and 95.6% of patients. Estimated cardiovascular risk decreased from 4.5% at baseline to 1% at 2 years after surgery.
  
  
  CONCLUSIONS
  SM is common in morbidly obese patients. Bypass gastric is associated with an improvement or resolution in cardiovascular risk factors and IR and result in a significant reduction in MS prevalence and of predicted 10-year cardiovascular risk.
authors.affiliation: Unidad de Nutrición, Servicio de Endocrinología y Nutrición, Hospital Clínico Universitario Lozano Blesa, Zaragoza, España. mjocon@salud.aragon.es
authors.forename: Julia
authors.initials: J
authors.lastname: Ocón Bretón
authors.forename: B
authors.initials: B
authors.lastname: García
authors.forename: P
authors.initials: P
authors.lastname: Benito
authors.forename: S
authors.initials: S
authors.lastname: Gimeno
authors.forename: R
authors.initials: R
authors.lastname: García
authors.forename: P
authors.initials: P
authors.lastname: López
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000517:prevention & control; D005260:Female; D015390:Gastric Bypass; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology* / Q000628:therapy*; D008875:Middle Aged; D009767:Obesity, Morbid / Q000628:therapy; D012307:Risk Factors; D015431:Weight Loss