VASCULAR MECHANICS, MECHANOBIOLOGY, AND REMODELING.
Arteries exhibit a remarkable ability to adapt in response to sustained alterations in hemodynamic loading as well as in response to disease, injury, and clinical treatment. A better understanding of such adaptations will be aided greatly by formulating, testing, and refining appropriate theoretical frameworks for modeling the biomechanics and associated mechanobiology. The goal of this brief review is to highlight some recent developments in the use of a constrained mixture theory of arterial growth and remodeling, with particular attention to the requisite constitutive relations, and to highlight future directions of needed research.
Humphrey
J D
JD
Department of Biomedical Engineering, 337 Zachry Engineering Center, Texas A&M University, College Station, TX 77843-3120 USA.