title: Point-of-care Arkansas method for measuring adherence to treatment with isoniazid.
abstract: We evaluated the accuracy of a point-of-care test designed to measure adherence to isoniazid (INH) preventive therapy in a hospital setting in Rio de Janeiro, Brazil. Patients on treatment with daily INH and patients not receiving INH were included. Sensitivity and specificity of the test were 84%/98% at the first minute, and 95%/98% at the fifth minute, respectively. Among smokers, sensitivity and specificity was reduced (80%/89% at the fifth minute, respectively), but only 17% smoked. This test accurately detected INH metabolites 24h following directly observed INH intake, though sensitivity and specificity may be compromised by tobacco smoke exposure.
authors.affiliation: Tuberculosis Clinical Research Laboratory, Institute of Thoracic Diseases, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. leborato@hucff.ufrj.br
authors.forename: Renata L
authors.initials: RL
authors.lastname: Guerra
authors.forename: Marcus B
authors.initials: MB
authors.lastname: Conde
authors.forename: Anne
authors.initials: A
authors.lastname: Efron
authors.forename: Carla
authors.initials: C
authors.lastname: Loredo
authors.forename: Gisele
authors.initials: G
authors.lastname: Bastos
authors.forename: Richard E
authors.initials: RE
authors.lastname: Chaisson
authors.forename: Jonathan E
authors.initials: JE
authors.lastname: Golub
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000652:urine*; D001938:Brazil; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage / Q000652:urine*; D008297:Male; D055118:Medication Adherence; D012680:Sensitivity and Specificity; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000652:urine*
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid