title: [Chilblain lupus in an adolescent].
abstract: Chilblain lupus or lupus pernio is a particular clinical type of cutaneous chronic lupus erythematosus, more frequently met in adults and difficult do diagnose without specific lesions at the level of the face and/or the scalp. The patient B.A., female, aged 16 is hospitalized in the Dermatological Clinic Iasi for some red-to-violaceous plaques, infiltrated, slightly scaling located around the nails and on the hands and legs finger sides. The lesions come up at the age of 13 become even more serious and painful in cold weather, getting better in the warm season when they become slightly pruriginous and are accompanied by a discrete facial erythema in "vespertilio", completely neglected by the patient. The general status was very good during this time, without general manifestations or visceral touches. The clinical diagnosis that was initially suggested, pernio, was afterwards denied by a detailed anamnesis, by laboratory testes (positive antinuclear antibodies, positive anti-double-stranded DNA antibodies) and by the histopathological examination of the biopsy from cutaneous lesions. The introduction of the antimalarial drugs (Plaquenil 200 mg/ day) associated with photoprotective creams, led to cure of cutaneous lesions.
authors.affiliation: Facultatea de Medicină, Clinica Dermatologie, Universitatea de Medicină si Farmacie "Gr.T. Popa" Iaşi.
authors.forename: Daciana Elena
authors.initials: DE
authors.lastname: Brănişteanu
authors.forename: Andreea Dana
authors.initials: AD
authors.lastname: Molodoi
authors.forename: Laura
authors.initials: L
authors.lastname: Stătescu
authors.forename: Zenaida
authors.initials: Z
authors.lastname: Petrescu
authors.forename: Daniela
authors.initials: D
authors.lastname: Vasiluţ
authors.forename: Ecaterina
authors.initials: E
authors.lastname: Anisiei
authors.forename: D
authors.initials: D
authors.lastname: Ferariu
authors.forename: D
authors.initials: D
authors.lastname: Brănişteanu
mesh_terms: D000293:Adolescent; D000974:Antibodies, Antinuclear / Q000097:blood; D018501:Antirheumatic Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D002647:Chilblains / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D003879:Dermatologic Agents / Q000627:therapeutic use*; D003937:Diagnosis, Differential; D004890:Erythema / Q000473:pathology; D005145:Face / Q000473:pathology; D005260:Female; D005385:Fingers / Q000473:pathology; D006225:Hand / Q000473:pathology; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use*; D008178:Lupus Erythematosus, Cutaneous / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D009262:Nails / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000974:Antibodies, Antinuclear; D018501:Antirheumatic Agents; D015415:Biomarkers; D003879:Dermatologic Agents; D006886:Hydroxychloroquine