title: Acute eosinophilic myocarditis: diagnosis and treatment.
abstract: Hypereosinophilic syndrome (HES) is a rare disorder of unregulated eosinophilia, which if untreated, may lead to systemic tissue infiltration and inflammation. Cardiac involvement is a common and serious associated complication. We describe a case of HES associated myocarditis mimicking a non-ST elevation MI (NSTEMI). Unlike myocarditis in general, our patient responded well to high dose methylprednisone, the standard of care in HES. We review the clinical presentation, pathophysiology, pathology and treatment of eosinophilic myocarditis related to HES.
authors.affiliation: New Jersey Medical School, Newark, NJ 07101, USA.
authors.forename: Houman
authors.initials: H
authors.lastname: Rezaizadeh
authors.forename: Monica
authors.initials: M
authors.lastname: Sanchez-Ross
authors.forename: Edo
authors.initials: E
authors.lastname: Kaluski
authors.forename: Marc
authors.initials: M
authors.lastname: Klapholz
authors.forename: Bunyad
authors.initials: B
authors.lastname: Haider
authors.forename: Christine
authors.initials: C
authors.lastname: Gerula
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018771:Arthralgia / Q000209:etiology; D001706:Biopsy; D002637:Chest Pain / Q000209:etiology; D003402:Creatine Kinase / Q000097:blood; D003937:Diagnosis, Differential; D004030:Dientamoebiasis / Q000150:complications / Q000188:drug therapy; D004562:Electrocardiography; D004804:Eosinophils; D005260:Female; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy* / Q000378:metabolism; D007958:Leukocyte Count; D008775:Methylprednisolone / Q000627:therapeutic use; D009205:Myocarditis / Q000175:diagnosis* / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D016896:Treatment Outcome; D019210:Troponin I / Q000097:blood
chemical_list: D000893:Anti-Inflammatory Agents; D019210:Troponin I; D003402:Creatine Kinase; D008775:Methylprednisolone