title: Reaction of Fe3(CO)12 with octreotide--chemical, electrochemical and biological investigations.
abstract: In search for peptidic [FeFe] hydrogenase mimics, the cyclic disulfide Sandostatin (octreotide) was allowed to react with Fe(3)(CO)(12). An octreotide-Fe(2)(CO)(6) complex was isolated and characterized spectroscopically as well as by elemental and thermochemical analysis. The complex catalyzes the electrochemical reduction of H(+) to H(2). It is suggested by radioligand binding assays that the complex retains much of the binding affinity for the somatostatin hsst(1-5) receptors of octreotide.
authors.affiliation: Institut für anorganische und analytische Chemie, Friedrich-Schiller Universität, August-Bebel-Strasse 2, 07751, Jena, Germany.
authors.forename: Ulf-Peter
authors.initials: UP
authors.lastname: Apfel
authors.forename: Manfred
authors.initials: M
authors.lastname: Rudolph
authors.forename: Christina
authors.initials: C
authors.lastname: Apfel
authors.forename: Christian
authors.initials: C
authors.lastname: Robl
authors.forename: Daniel
authors.initials: D
authors.lastname: Langenegger
authors.forename: Daniel
authors.initials: D
authors.lastname: Hoyer
authors.forename: Bernhard
authors.initials: B
authors.lastname: Jaun
authors.forename: Marc-Olivier
authors.initials: MO
authors.lastname: Ebert
authors.forename: Theodor
authors.initials: T
authors.lastname: Alpermann
authors.forename: Dieter
authors.initials: D
authors.lastname: Seebach
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Weigand
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry*; D001426:Bacterial Proteins / Q000737:chemistry; D002254:Carbonates / Q000737:chemistry*; D020134:Catalytic Domain; D055664:Electrochemical Techniques; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D006864:Hydrogenase / Q000737:chemistry; D007506:Iron-Sulfur Proteins / Q000737:chemistry; D015394:Molecular Structure; D015282:Octreotide / Q000737:chemistry*; D013004:Somatostatin / Q000737:chemistry
chemical_list: D018931:Antineoplastic Agents, Hormonal; D001426:Bacterial Proteins; D002254:Carbonates; D005290:Ferric Compounds; D007506:Iron-Sulfur Proteins; D013004:Somatostatin; C118830:iron hydrogenase; D006864:Hydrogenase; D015282:Octreotide