title: LHRH-targeted nanoparticles for cancer therapeutics.
abstract: Synthesis and evaluation of a novel cancer cell's receptor-targeted internally quaternized and surface neutral poly(amidoamine) (PAMAM) generation four dendrimer as well as PAMAM-paclitaxel conjugate are described. The advantages of developed nanocarriers include but are not limited to (1) internal cationic charges for the complexation with small interfering RNA or antisense oligonucleotides and their protection from the degradation in systemic circulation; (2) neutral-modified surface for low cytotoxicity of empty unloaded dendrimers; (3) efficient internalization by cancer cells; and (4) preferential accumulation in the tumor and the prevention of adverse side effects of chemotherapy.
authors.affiliation: Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
authors.forename: Tamara
authors.initials: T
authors.lastname: Minko
authors.forename: Mahesh L
authors.initials: ML
authors.lastname: Patil
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Jayant J
authors.initials: JJ
authors.lastname: Khandare
authors.forename: Maha
authors.initials: M
authors.lastname: Saad
authors.forename: Pooja
authors.initials: P
authors.lastname: Chandna
authors.forename: Oleh
authors.initials: O
authors.lastname: Taratula
mesh_terms: D000107:Acetylation / Q000187:drug effects; D000818:Animals; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000737:chemistry / Q000627:therapeutic use*; D051379:Mice; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D009369:Neoplasms / Q000628:therapy*; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology; D013499:Surface Properties / Q000187:drug effects; D014018:Tissue Distribution / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D050091:Dendrimers; C104700:PAMAM Starburst; D007987:Gonadotropin-Releasing Hormone; D017239:Paclitaxel