Metal impurities in food and drugs.
The major metals of potential health concern found in food, drugs (medicines), and dietary supplements are lead, cadmium, mercury, and arsenic. Other metals, such as chromium, copper, manganese, molybdenum, vanadium, nickel, osmium, rhodium, ruthenium, iridium, palladium, and platinum, may be used or introduced during manufacturing and may be controlled in the final article as impurities. Screening for metals in medicines and dietary supplements rarely indicates the presence of toxic metal impurities at levels of concern. The setting of heavy metal limits is appropriate for medicines and is appropriate for supplements when heavy metals are likely or certain to contaminate a given product. Setting reasonable health-based limits for some of these metals is challenging because of their ubiquity in the environment, limitations of current analytical procedures, and other factors. Taken together, compendial tests for metals in food and drugs present an array of issues that challenge compendial scientists.
Abernethy
Darrell R
DR
Documentary Standards Division, US Pharmacopeia, Rockville, Maryland 20852-1790, USA.
Destefano
Anthony J
AJ
Cecil
Todd L
TL
Zaidi
Kahkashan
K
Williams
Roger L
RL
D000818:Animals; D002626:Chemistry, Pharmaceutical; D004340:Drug Contamination; D005504:Food Analysis; D005506:Food Contamination / Q000032:analysis*; D006801:Humans; D008670:Metals / Q000032:analysis* / Q000633:toxicity; D010602:Pharmacopoeias as Topic; D020711:Threshold Limit Values
D008670:Metals