title: Doppler variance imaging for three-dimensional retina and choroid angiography.
abstract: We demonstrate the use of Doppler variance (standard deviation) imaging for 3-D in vivo angiography in the human eye. In addition to the regular optical Doppler tomography velocity and structural images, we use the variance of blood flow velocity to map the retina and choroid vessels. Variance imaging is subject to bulk motion artifacts as in phase-resolved Doppler imaging, and a histogram-based method is proposed for bulk-motion correction in variance imaging. Experiments were performed to demonstrate the effectiveness of the proposed method for 3-D vasculature imaging of human retina and choroid.
authors.affiliation: University of California, Irvine, Irvine Beckman Laser Institute, Department of Biomedical Engineering, Irvine, California 92612, USA. yulingfeng@gmail.com
authors.forename: Lingfeng
authors.initials: L
authors.lastname: Yu
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
mesh_terms: D002829:Choroid / Q000033:anatomy & histology / Q000098:blood supply*; D004301:Doppler Effect; D005654:Fundus Oculi; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D012171:Retinal Vessels / Q000033:anatomy & histology*; D041623:Tomography, Optical Coherence / Q000379:methods*