New inhibitors for expression of IgE receptor on human mast cell.
Exploration for inhibitors against expression of IgE receptor (Fc epsilonRI) on human mast cell, a significant trigger to acute and chronic allergic symptoms, disclosed epigallocatechin gallate (EGCG), epicatechin gallate, and gallocatechin gallate as active principles. Additionally, the anthocyanidin, delphinidin, and the flavone, tricetinidin, possessing a pyrogallol function were also revealed to suppress expression of Fc epsilonRI. Structure-activity relationship analysis among catechins, anthocyanidins, and flavones revealed the pyrogallol moiety to be crucial for biological potency. Furthermore, EGCG was clarified to reduce generation of gamma-chain subunit to suppress expression of Fc epsilonRI on human mast cells.
Tamura
Satoru
S
Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamada-oka, Suita, Osaka 565-0871, Japan.
Yoshihira
Kunichika
K
Fujiwara
Katsuaki
K
Murakami
Nobutoshi
N
D000872:Anthocyanins / Q000737:chemistry / Q000494:pharmacology*; D018926:Anti-Allergic Agents / Q000737:chemistry / Q000494:pharmacology*; D002392:Catechin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D047309:Flavones; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D017455:Receptors, IgE / Q000235:genetics* / Q000378:metabolism
D000872:Anthocyanins; D018926:Anti-Allergic Agents; D047309:Flavones; D005419:Flavonoids; D017455:Receptors, IgE; D002392:Catechin; C045651:epigallocatechin gallate; C017185:delphinidin; C043562:flavone