title: Dietary patterns and risk of advanced prostate cancer: a principal component analysis in Uruguay.
abstract: OBJECTIVE
  In order to explore the role of broader eating patterns in the etiology of prostate cancer, we conducted a principal components analysis among Uruguayan men.
  
  
  METHODS
  The study included 345 newly diagnosed cases of advanced prostate cancer and 690 hospitalized controls. The factor analysis was performed using the control population.
  
  
  RESULTS
  Factor analysis allowed the extraction of five patterns, labeled as prudent, traditional, substituter, drinker, and Western. Whereas the traditional and Western patterns were directly associated with risk of prostate cancer (OR for high quartile versus the low quartile of the Western diet was 2.35, 95% CI 1.44-3.85, p-value for trend < 0.0001), the prudent, drinker, and substituter patterns were not associated with risk of the disease. After adjustment of each pattern for the foods with high loadings, these three patterns did not modify substantially their original ORs.
  
  
  CONCLUSIONS
  The Western and traditional patterns could partially explain the high incidence of advanced prostate cancer in Uruguay, a main producer of beef in the World.
authors.affiliation: Grupo de Epidemiología, Departamento de Anatomía Patológica, Facultad de Medicina, Hospital de Clínicas, Avenida Brasil 3080 dep 402, 11300 Montevideo, Uruguay. estefani@adinet.com.uy
authors.forename: Eduardo
authors.initials: E
authors.lastname: De Stefani
authors.forename: Alvaro L
authors.initials: AL
authors.lastname: Ronco
authors.forename: Hugo
authors.initials: H
authors.lastname: Deneo-Pellegrini
authors.forename: Paolo
authors.initials: P
authors.lastname: Boffetta
authors.forename: Dagfinn
authors.initials: D
authors.lastname: Aune
authors.forename: Gisele
authors.initials: G
authors.lastname: Acosta
authors.forename: Paul
authors.initials: P
authors.lastname: Brennan
authors.forename: Gilles
authors.initials: G
authors.lastname: Ferro
authors.forename: María
authors.initials: M
authors.lastname: Mendilaharsu
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D004034:Diet Surveys; D005247:Feeding Behavior / Q000145:classification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D025341:Principal Component Analysis; D011471:Prostatic Neoplasms / Q000453:epidemiology*; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014583:Uruguay / Q000453:epidemiology