title: Mitochondrial DNA haplogroup distribution in Chaoshanese with and without myopia.
abstract: OBJECTIVE
  Mitochondrial DNA (mtDNA) haplogroups affect the clinical expression of Leber hereditary optic neuropathy, age-related macular degeneration, and other diseases. The objective of this study is to investigate whether an mtDNA background is associated with myopia.
  
  
  METHODS
  Blood DNA was obtained from 192 college students, including 96 individuals with moderate-to-high myopia and 96 controls without myopia. All the subjects were from a well-known isolated population living in the Chaoshan area of east Guangdong Province and speaking one of the four major dialects in southern China. The mtDNA haplogroups in the 192 subjects were determined by sequencing the mtDNA control region and partial coding regions as well as by analysis of restriction fragment length polymorphisms. Each mtDNA was classified according to the updated version of the Eastern Asian haplogroup system.
  
  
  RESULTS
  Sixteen mtDNA haplogroups were recognized in the 192 subjects. The overall matrilineal structures of the samples with and without myopia were similar and had genetic imprints showing their ethno-origin. There was no statistical difference in frequencies of haplogroup distribution between subjects with and without myopia (chi(2) test, p=0.556).
  
  
  CONCLUSIONS
  We failed to identify clues that suggest an involvement of mtDNA background in the predisposition to myopia.
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
authors.forename: Qin
authors.initials: Q
authors.lastname: Wang
authors.forename: Panfeng
authors.initials: P
authors.lastname: Wang
authors.forename: Shiqiang
authors.initials: S
authors.lastname: Li
authors.forename: Xueshan
authors.initials: X
authors.lastname: Xiao
authors.forename: Xiaoyun
authors.initials: X
authors.lastname: Jia
authors.forename: Xiangming
authors.initials: X
authors.lastname: Guo
authors.forename: Qing-Peng
authors.initials: QP
authors.lastname: Kong
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Yao
authors.forename: Qingjiong
authors.initials: Q
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D004272:DNA, Mitochondrial / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008297:Male; D009216:Myopia / Q000235:genetics*; D025341:Principal Component Analysis; D055815:Young Adult
chemical_list: D004272:DNA, Mitochondrial