Toxicokinetic interaction between quetiapine and antiretroviral therapy following quetiapine overdose.
A 47-year-old woman ingested an overdose of 8000 mg quetiapine. The treatment had been initiated 3 weeks before. The current medications were lamuvidine, ritonavir, atazanavir and tenofovir for an HIV infection. The patient presented a deep coma and sustained hypotension as main complications. The toxicokinetic data revealed a markedly prolonged elimination half-life for quetiapine (62.4 hours) and the relationship with antiretroviral therapy is discussed.
Hantson
P
P
Department of Intensive Care, Cliniques St-Luc, Université catholique de Louvain, Brussels, Belgium. philippe.hantson@uclouvain.be
Di Fazio
V
V
Wallemacq
P
P
D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000493:pharmacokinetics / Q000506:poisoning*; D003128:Coma / Q000139:chemically induced; D003987:Dibenzothiazepines / Q000493:pharmacokinetics / Q000506:poisoning*; D004347:Drug Interactions; D062787:Drug Overdose; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D006207:Half-Life; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D008875:Middle Aged; D000069348:Quetiapine Fumarate
D019380:Anti-HIV Agents; D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D000069348:Quetiapine Fumarate