title: Advances in identifying beryllium sensitization and disease.
abstract: Beryllium is a lightweight metal with unique qualities related to stiffness, corrosion resistance, and conductivity. While there are many useful applications, researchers in the 1930s and 1940s linked beryllium exposure to a progressive occupational lung disease. Acute beryllium disease is a pulmonary irritant response to high exposure levels, whereas chronic beryllium disease (CBD) typically results from a hypersensitivity response to lower exposure levels. A blood test, the beryllium lymphocyte proliferation test (BeLPT), was an important advance in identifying individuals who are sensitized to beryllium (BeS) and thus at risk for developing CBD. While there is no true "gold standard" for BeS, basic epidemiologic concepts have been used to advance our understanding of the different screening algorithms.
authors.affiliation: Division of Health Studies, Agency for Toxic Substances and Disease Registry, Atlanta, GA 30341, USA. dcm2@cdc.gov
authors.forename: Dan
authors.initials: D
authors.lastname: Middleton
authors.forename: Peter
authors.initials: P
authors.lastname: Kowalski
mesh_terms: D001607:Berylliosis / Q000175:diagnosis*; D001608:Beryllium / Q000276:immunology / Q000633:toxicity*; D006801:Humans; D008962:Models, Theoretical; D011338:Probability Theory
chemical_list: D001608:Beryllium