title: Maternal and cord blood levels of aldrin and dieldrin in Delhi population.
abstract: Aldrin and dieldrin, structurally similar organochlorine pesticides belong to cyclodiene family and were widely used for agriculture and public health program in India. Although the manufacturing, use and import of aldrin and dieldrin have been banned in India since 2003, these pesticides are still persistent in environment and may be associated with adverse neurological and reproductive effects. The aim of this study is to assess the recent exposure level of aldrin and dieldrin and their placental transfer to fetus in normal healthy full-term pregnant women belonging to north Indian population undergoing normal delivery at Obstetrics and Gynecology department of UCMS and GTB hospital, Delhi. Quantitative analysis of aldrin and dieldrin residues in maternal and cord blood samples were carried out by gas chromatography system equipped with electron capture detector. The results of our study clearly revealed that maternal and cord blood levels of aldrin and dieldrin of pregnant women are age and dietary habit dependent. The aldrin level in maternal blood and dieldrin level in cord blood are higher in women in the age group 25-30 years than in women in age group of 19-24 years. Similarly, aldrin level in maternal blood is significantly higher in women with non-vegetarian dietary habit than in women with vegetarian dietary habit. No significant association is found for maternal and cord blood level. The results of the present study clearly demonstrate prenatal uptake of aldrin and dieldrin and provide recent information on the subsequent transplacental transfer.
authors.affiliation: Environmental Biochemistry and Immunology Laboratory, Department of Biochemistry, University College of Medical Sciences & G.T.B. Hospital, University of Delhi, Dilshad Garden, Delhi, 110 095, India.
authors.forename: Md
authors.initials: M
authors.lastname: Mustafa
authors.forename: Rahul
authors.initials: R
authors.lastname: Pathak
authors.forename: A K
authors.initials: AK
authors.lastname: Tripathi
authors.forename: Rafat S
authors.initials: RS
authors.lastname: Ahmed
authors.forename: Kiran
authors.initials: K
authors.lastname: Guleria
authors.forename: B D
authors.initials: BD
authors.lastname: Banerjee
mesh_terms: D000328:Adult; D000452:Aldrin / Q000097:blood*; D004026:Dieldrin / Q000097:blood*; D004032:Diet; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007194:India; D007306:Insecticides / Q000097:blood*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D007306:Insecticides; D004026:Dieldrin; D000452:Aldrin