Low level of serum interleukin 27 in patients with systemic lupus erythematosus.
T helper 17 (TH17) cells are beginning to be implicated in the pathogenesis of systemic lupus erythematosus (SLE). Recent studies have shown that interleukin 27 (IL-27) controls the development of TH17. However, whether IL-27 plays a role in the development of SLE is still unclear. In the present work, we investigated the serum IL-27 level in SLE and its relations to disease activity. Fifty-six patients with SLE and 30 healthy volunteers were recruited. Serum IL-27 levels were detected by enzyme-linked immunosorbent assay. The clinical and laboratory parameters were collected from medical records or by questionnaire. The serum IL-27 level in SLE patients was significantly lower than that in healthy controls (P < 0.001). Compared with SLE patients without nephritis, patients with nephritis had a significantly decreased serum IL-27 level (P < 0.05). However, there was no significant difference between less active and more active SLE (P > 0.05). Correlation analysis between serum IL-27 levels and SLE disease activity index showed no association (P > 0.05). In summary, a decrease in serum IL-27 level in patients with SLE suggested that this cytokine might be implicated in the pathomechanism of this disease.
Li
Ting-Ting
TT
Department of Epidemiology and Biostatistics, Anhui Medical University, Hefei, PR China.
Zhang
Tao
T
Chen
Gui-Mei
GM
Zhu
Qing-Qing
QQ
Tao
Jin-Hui
JH
Pan
Hai-Feng
HF
Ye
Dong-Qing
DQ
D000293:Adolescent; D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007378:Interleukins / Q000097:blood* / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000097:blood / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D055815:Young Adult
D007378:Interleukins; C464565:MYDGF protein, human