Hyaluronidase inhibitors from "Cimicifugae Rhizoma" (a mixture of the rhizomes of Cimicifuga dahurica and C. heracleifolia).
From the 80% acetone extract of "Cimicifugae Rhizoma" (a mixture of Cimicifuga dahurica and C. heracleifolia used medicinally), seven new fukiic acid derivatives (1-7) and a new phenylethanoid derivative (8) were isolated along with eight known compounds (9-16). Fukinolic acid (9) and cimicifugic acids A-J (10-16, 5-7) showed stronger hyaluronidase inhibitory activities than the positive control, rosmarinic acid.
Iwanaga
Atsufumi
A
School of Pharmaceutical Sciences, University of Shizuoka, Yada 52-1, Suruga-ku, Shizuoka 422-8526, Japan.
Kusano
Genjiro
G
Warashina
Tsutomu
T
Miyase
Toshio
T
D002109:Caffeic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031885:Cimicifuga / Q000737:chemistry*; D002934:Cinnamates / Q000737:chemistry; D053630:Depsides / Q000737:chemistry; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors*; D007564:Japan; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010648:Phenylacetates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010666:Phenylpropionates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D027343:Rhizome / Q000737:chemistry; D013386:Succinates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000097123:Rosmarinic Acid
D002109:Caffeic Acids; D002934:Cinnamates; D053630:Depsides; D006821:Hyaluronoglucosaminidase; D010648:Phenylacetates; D010666:Phenylpropionates; D013386:Succinates; D000097123:Rosmarinic Acid; C116092:cimicifugic acid; C116091:fukiic acid; C116090:fukinolic acid