Enantioselective organocatalytic mannich reactions with autocatalysts and their mimics.
The Mannich reactions previously extensively investigated with organocatalysis of l-proline and other related small molecules were reinvestigated with detailed stereochemical analysis of their autocatalysis pathways, through employment of both the products themselves and their close structural mimics as the catalysts. These organo-autocatalytic processes function as meaningful molecular models toward understanding the origin and maintenance of homochirality under biologically relevant conditions.
Wang
Xinbo
X
School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen University Town, Shenzhen 518055, China.
Zhang
Yongbo
Y
Tan
Haibo
H
Wang
Yanchao
Y
Han
Peng
P
Wang
David Zhigang
DZ
D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011392:Proline / Q000737:chemistry*; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
D009942:Organometallic Compounds; D011392:Proline; D015032:Zinc