Real-time photoacoustic tomography of cortical hemodynamics in small animals.
For the first time, the hemodynamics within the entire cerebral cortex of a mouse were studied by using photoacoustic tomography (PAT) in real time. The PAT system, based on a 512-element full-ring ultrasound array, received photoacoustic signals primarily from a slice of 2-mm thickness. This system can provide high-resolution brain vasculature images. We also monitored the fast wash-in process of a photoacoustic contrast agent in the mouse brain. Our results demonstrated that PAT is a powerful imaging modality that can be potentially used to study small animal neurofunctional activities.
Li
Changhui
C
Aguirre
Andres
A
Gamelin
John
J
Maurudis
Anastasios
A
Zhu
Quing
Q
Wang
Lihong V
LV
D000818:Animals; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000098:blood supply*; D003287:Contrast Media / Q000737:chemistry; D004867:Equipment Design; D005070:Evans Blue / Q000737:chemistry; D006439:Hemodynamics; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D051379:Mice; D014054:Tomography / Q000295:instrumentation / Q000379:methods*; D014463:Ultrasonography / Q000379:methods
D003287:Contrast Media; D005070:Evans Blue