CLC-3 chloride channels in the pulmonary vasculature.
Volume-sensitive outwardly rectifying anion channels (VSOACs) are expressed in pulmonary artery smooth muscle cells (PASMCs) and have been implicated in cell proliferation, growth, apoptosis and protection against oxidative stress. In this chapter, we review the properties of native VSOACs in PASMCs, and consider the evidence that ClC-3, a member of the ClC superfamily of voltage dependent Cl- channels, may be responsible for native VSOACs in PASMCs. Finally, we examine whether or not native VSOACs and heterologously expressed ClC-3 channels function as bona fide chloride channels or as chloride/proton antiporters.
Hume
Joseph R
JR
Department of Pharmacology, Center of Biomedical Research Excellence, University of Nevada School of Medicine, Reno, NV, 89557, USA. jhume@medicine.nevada.edu
Wang
Ge-Xin
GX
Yamazaki
Jun
J
Ng
Lih Chyuan
LC
Duan
Dayue
D
D000818:Animals; D000838:Anions / Q000378:metabolism; D002460:Cell Line; D018118:Chloride Channels / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000098:blood supply* / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000166:cytology*; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000378:metabolism*; D011522:Protons; D011652:Pulmonary Circulation / Q000502:physiology
D000838:Anions; D018118:Chloride Channels; D002712:Chlorides; C115376:ClC-3 channel; D011522:Protons