title: Magnetic resonance imaging of pachymeningeal enhancement in Vogt-Koyanagi-Harada disease.
abstract: Vogt-Koyanagi-Harada (VKH) disease is a systemic disease consisting of bilateral granulomatous panuveitis combined with cutaneous and neurologic manifestations. However, there have been few reports of brain magnetic resonance imaging (MRI) in VKH disease. A 54-year-old Korean woman presented with severe periorbital pain, blurred vision and meningismus. Ophthalmologic examination disclosed bilateral optic disc edema with peripapillary nerve fiber hemorrhages. Lumbar puncture revealed monocytic pleocytosis. After a diagnosis of VKH disease was made, the patient was treated with high-dose corticosteroid. Brain MRI showed diffusely thickened posterior ocular walls with retinal detachment and perineural infiltrative changes along the optic nerves and adjacent pachymeningeal enhancement of the anterior temporal lobes bilaterally. We report a case of VKH disease with panuveitis and meningeal involvement of the anterior temporal lobe detected by brain MRI.
authors.affiliation: Department of Neurology, College of Medicine, Myongji Hospital, Kwandong University, Gyeonggi-do, Korea. neurohan@kd.ac.kr
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Han
authors.forename: Hye Yun
authors.initials: HY
authors.lastname: Kim
authors.forename: Jong-Ho
authors.initials: JH
authors.lastname: Park
authors.forename: Eun Ja
authors.initials: EJ
authors.lastname: Lee
authors.forename: Do Gyun
authors.initials: DG
authors.lastname: Kim
authors.forename: Dong-Ick
authors.initials: DI
authors.lastname: Shin
mesh_terms: D005260:Female; D005451:Fluorescein Angiography / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008578:Meninges / Q000473:pathology; D008875:Middle Aged; D015864:Panuveitis / Q000209:etiology / Q000473:pathology; D010211:Papilledema / Q000209:etiology / Q000473:pathology*; D012163:Retinal Detachment / Q000209:etiology / Q000473:pathology; D013702:Temporal Lobe / Q000473:pathology*; D014607:Uveomeningoencephalitic Syndrome / Q000150:complications / Q000473:pathology*