title: Relation of anti- to pro-inflammatory cytokine ratios with acute myocardial infarction.
abstract: OBJECTIVE
  Acute myocardial infarction (AMI) is a leading cause of death. Inflammatory processes play an important role in atherosclerosis, which is intimately related to AMI. The aim of this study was to investigate the association between anti-inflammatory and pro-inflammatory cytokines ratios and AMI.
  
  
  METHODS
  A total of 90 AMI patients and 90 age-and sex-matched controls were recruited in this study. Plasma cytokines and conventional risk factors were determined by standard methods.
  
  
  RESULTS
  Patients with AMI showed increased interleukin (IL)-6 and tumor necrosis factor-alpha levels and lower anti- to pro-inflammatory cytokine ratios as compared with controls. A multivariate logistic regression analysis revealed that IL-10 to IL-6 ratio was independently associated with the occurrence of AMI (odds ratio [OR], 5.39; 95% confidence interval [CI], 2.39 to 12.17; p < 0.0001). In contrast, IL-6 levels were no longer significant in the multivariate model (OR, 1.02; 95% CI, 0.932 to 1.12; p = 0.603). A receiver operating characteristic (ROC) curve analysis indicated that IL-6 levels and IL-10 to IL-6 ratios were a significant predictor of AMI (area under ROC curve, 0.892 and 0.851, respectively).
  
  
  CONCLUSIONS
  Our results suggest that the ratio of IL-10 to IL-6 is independently associated with AMI, and reduced levels of this ratio may favor the development of AMI.
authors.affiliation: Division of Molecular Medicine, Bose Institute, p-1/12 CIT Scheme VIIM, Kolkata-700054, India.
authors.forename: Santanu
authors.initials: S
authors.lastname: Biswas
authors.forename: Pradip K
authors.initials: PK
authors.lastname: Ghoshal
authors.forename: Sankar C
authors.initials: SC
authors.lastname: Mandal
authors.forename: Nripendranath
authors.initials: N
authors.lastname: Mandal
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000453:epidemiology / Q000276:immunology; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood / Q000453:epidemiology / Q000276:immunology; D011237:Predictive Value of Tests; D012372:ROC Curve; D012307:Risk Factors
chemical_list: C508609:IL10 protein, human; C508600:IL6 protein, human; D015850:Interleukin-6; D016753:Interleukin-10