title: MARCH-I: a new regulator of dendritic cell function.
abstract: We and other groups have demonstrated that the expression level of MHC class II (MHC II) is regulated through ubiquitination of the MHC II beta chain. We also reported that MARCH-I, an E3 ubiquitin ligase, is critical for this process. At present, however, the importance of MARCH-I-mediated MHC II regulation in vivo is still unknown. In this review, we will summarize recent advances in our understanding of MARCH-I-mediated MHC II ubiquitination, and discuss how we can overcome the difficulties inherent in these studies.
authors.affiliation: Laboratory for Infectious Immunity, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, 230-0045, Japan. ishido@rcai.riken.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishido
authors.forename: Yohei
authors.initials: Y
authors.lastname: Matsuki
authors.forename: Eiji
authors.initials: E
authors.lastname: Goto
authors.forename: Mizuho
authors.initials: M
authors.lastname: Kajikawa
authors.forename: Mari
authors.initials: M
authors.lastname: Ohmura-Hoshino
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000502:physiology*; D003713:Dendritic Cells / Q000201:enzymology / Q000502:physiology*; D055879:Gene Knock-In Techniques; D005802:Genes, MHC Class II; D000949:Histocompatibility Antigens Class II / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008221:Lymphoid Tissue / Q000201:enzymology / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D011499:Protein Processing, Post-Translational / Q000502:physiology; D044767:Ubiquitin-Protein Ligases / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D054875:Ubiquitination
chemical_list: D000949:Histocompatibility Antigens Class II; C545340:MARCH1 protein, mouse; D044767:Ubiquitin-Protein Ligases