Wernicke's encephalopathy during total parenteral nutrition in a child with acute lymphoblastic leukemia and acute pancreatitis.
We herein describe a 16-year-old child with acute lymphoblastic leukemia and acute pancreatitis who developed Wernicke's encephalopathy secondary to prolonged total parenteral nutrition (TPN) that lacked vitamin B1 supplementation. The patient showed a direct and complete response to thiamine therapy. Diagnostic challenges are discussed and recommendations for prophylactic vitamin B1 supplementation in children with leukemia who are placed on TPN are made.
Muwakkit
S
S
Department of Pediatrics, Medical Center, American University of Beirut, Beirut, Lebanon. sm03@aub.edu.lb
Al-Aridi
C
C
Saab
R
R
Hourani
R
R
Yazbeck
N
N
Abboud
M
M
D000293:Adolescent; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000150:complications / Q000628:therapy; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000628:therapy; D013831:Thiamine / Q000627:therapeutic use; D014899:Wernicke Encephalopathy / Q000209:etiology*
D013831:Thiamine