title: Novel one-pot facile technique for preparing nanoparticles modified with hydrophilic polymers on the surface via block polymer-assisted emulsification/evaporation process.
abstract: In this paper, we describe the novel facile technique for preparing surface-modified nanoparticles via newly developed amphiphilic block polymer-assisted emulsification/evaporation process. The effects of both organic solvents (the dispersed phase) and stabilizer in the external continuous phase on the stability of o/w emulsion was firstly investigated to clarify the optimal conditions for stable emulsification/evaporation processes. We found that the organic solvent mixture having a density adjusted to be 1.00 g/cm(3) gave the highly stable o/w emulsion. Under the optimal conditions, the relatively monodisperse poly(ethylene glycol) (PEG)-modified poly(lactide-co-glycolide) (PLGA) nanoparticle was obtained and characterized. The introduction of PEG to the particle surface was suggested by the fact that the diameter and zeta potential of the particle increased as the amount of added block polymer increased. The facile method presented in this paper can be a universal tool for modifying the surface of nanoparticles, even though reactive groups are not present on the surface.
authors.affiliation: Department of Organic and Polymer Materials Chemistry, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: Yurie
authors.initials: Y
authors.lastname: Kanakubo
authors.forename: Fuminori
authors.initials: F
authors.lastname: Ito
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Murakami
mesh_terms: D004655:Emulsions; D019344:Lactic Acid / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D009821:Oils / Q000737:chemistry; D009930:Organic Chemicals / Q000737:chemistry; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011142:Polyvinyl Alcohol / Q000737:chemistry; D012997:Solvents / Q000737:chemistry; D013499:Surface Properties; D014835:Volatilization; D014867:Water / Q000737:chemistry
chemical_list: D004655:Emulsions; D009821:Oils; D009930:Organic Chemicals; D012997:Solvents; D014867:Water; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011142:Polyvinyl Alcohol