title: Epidemiologic features and virus isolation of enteroviruses in Northern Taiwan during 2000-2008.
abstract: The susceptibility of five cell lines, RD, MRC-5, MK-2, Hep-2 and A549, for various serotypes of human enteroviruses was evaluated. RD cells were susceptible to most serotypes of enteroviruses, especially for human enterovirus A. Consequently, a high prevalence of human enterovirus A in Taiwan may reflect the relative importance of RD cells in the clinical virology laboratory. However, susceptibilities of RD cells to coxsackievirus A9 and A24, and echovirus 9 and 11 were exceptionally low. Alternatively, MRC-5 or MK-2 cells can improve the isolation of these four enteroviruses.
authors.affiliation: Research Center for Emerging Viral Infections, Chang Gung University, Kwei-Shan, Tao-Yuan, Taiwan.
authors.forename: Kuo-Chien
authors.initials: KC
authors.lastname: Tsao
authors.forename: Chung-Guei
authors.initials: CG
authors.lastname: Huang
authors.forename: Ya-Ling
authors.initials: YL
authors.lastname: Huang
authors.forename: Feng-Chu
authors.initials: FC
authors.lastname: Chen
authors.forename: Peng-Nien
authors.initials: PN
authors.lastname: Huang
authors.forename: Yuh-Chering
authors.initials: YC
authors.lastname: Huang
authors.forename: Tzou-Yen
authors.initials: TY
authors.lastname: Lin
authors.forename: Shin-Ru
authors.initials: SR
authors.lastname: Shih
authors.forename: Shih-Cheng
authors.initials: SC
authors.lastname: Chang
mesh_terms: D000818:Animals; D002460:Cell Line; D003384:Coxsackievirus Infections / Q000175:diagnosis* / Q000453:epidemiology* / Q000821:virology; D004770:Enterovirus / Q000254:growth & development / Q000302:isolation & purification*; D006801:Humans; D013624:Taiwan / Q000453:epidemiology; D014776:Virus Cultivation / Q000379:methods*