title: Clinical and virologic efficacy of herpes simplex virus type 2 suppression by acyclovir in a multicontinent clinical trial.
abstract: Acyclovir suppressive therapy (400 mg twice daily) reduces herpes simplex virus (HSV) type 2-associated genital ulcer disease and lesional HSV shedding. In an international trial of acyclovir for suppression of HSV type 2 to prevent human immunodeficiency virus (HIV) acquisition (HIV Prevention Trials Network 039), acyclovir had a smaller effect on the frequency of genital ulcer disease as well as a smaller effect on the frequency and quantity of lesional HSV DNA in African women and Peruvian men, compared with its effects in men in the United States. The observed regional variation in the clinical and virologic efficacy of acyclovir for HSV suppression warrants further evaluation of determinants of responses to acyclovir. (ClinicalTrials.gov identifier: NCT00076232.).
authors.affiliation: HIV Research Section, San Francisco Department of Public Health, San Francisco, CA 94102, USA. jonathan.fuchs@sfdph.org
authors.forename: Jonathan
authors.initials: J
authors.lastname: Fuchs
authors.forename: Connie
authors.initials: C
authors.lastname: Celum
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: James
authors.initials: J
authors.lastname: Hughes
authors.forename: Jorge
authors.initials: J
authors.lastname: Sanchez
authors.forename: Frances
authors.initials: F
authors.lastname: Cowan
authors.forename: Stewart
authors.initials: S
authors.lastname: Reid
authors.forename: Sinead
authors.initials: S
authors.lastname: Delany-Moretlwe
authors.forename: Lawrence
authors.initials: L
authors.lastname: Corey
authors.forename: Anna
authors.initials: A
authors.lastname: Wald
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000517:prevention & control; D006558:Herpes Genitalis / Q000188:drug therapy*; D018258:Herpesvirus 2, Human / Q000187:drug effects*; D006801:Humans; D008297:Male; D010568:Peru; D013019:South Africa; D014481:United States; D017201:Virus Shedding / Q000187:drug effects; D015024:Zambia; D015030:Zimbabwe
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir