title: Lack of association of common allelic variants in the thyroglobulin gene with Hashimoto's thyroiditis in young subjects with type 1 diabetes.
abstract: OBJECTIVE
  Four SNPs (E10SNP24, E10SNP158, E12SNP, E33SNP) in the Tg gene are suspected to be involved in the development of autoimmune thyroid diseases. The aim of the study was to determine whether these variants play a role in the development of Hashimoto's thyroiditis in young subjects with type 1 diabetes, in whom autoimmune thyroid diseases are significantly more common than in the general population.
  
  
  METHODS
  Seventy-six subjects with type 1 diabetes and Hashimoto's thyroiditis and 110 subjects with only type 1 diabetes were studied. Hashimoto's thyroiditis was determined according to the clinical, biochemical and ultrasonographic criteria. SNPs were determined by the TaqMan SNP method.
  
  
  RESULTS
  In young subjects with type 1 diabetes, no association between any of the tested SNPs or their combinations and Hashimoto's thyroiditis was found.
  
  
  CONCLUSIONS
  This is the first study to investigate the association of SNPs located inside the coding region of the Tg gene with the development of Hashimoto's thyroiditis in subjects with type 1 diabetes. The lack of an association is in concordance with a study where marker Tgms2, located inside intron 27, was not associated with joint susceptibility for autoimmune thyroid disease and type 1 diabetes.
authors.affiliation: Department of Pediatric Endocrinology, UMC University Children's Hospital, Ljubljana, Slovenia. primoz.kotnik @ mf.uni-lj.si
authors.forename: Primoz
authors.initials: P
authors.lastname: Kotnik
authors.forename: Marusa
authors.initials: M
authors.lastname: Debeljak
authors.forename: Magdalena
authors.initials: M
authors.lastname: Avbelj
authors.forename: Tinka
authors.initials: T
authors.lastname: Hovnik
authors.forename: Natasa
authors.initials: N
authors.lastname: Ursic Bratina
authors.forename: Ciril
authors.initials: C
authors.lastname: Krzisnik
authors.forename: Tadej
authors.initials: T
authors.lastname: Battelino
mesh_terms: D000483:Alleles; D016009:Chi-Square Distribution; D004247:DNA / Q000737:chemistry / Q000235:genetics; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000235:genetics* / Q000276:immunology; D005260:Female; D014644:Genetic Variation; D050031:Hashimoto Disease / Q000150:complications* / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D013954:Thyroglobulin / Q000235:genetics*; D055815:Young Adult
chemical_list: D004247:DNA; D013954:Thyroglobulin