Fatty acid-derived lipid mediators and blood platelet aggregation.
Polyunsaturated fatty acids of nutritional value may affect cell functions after their release from cell lipid storage sites, especially phospholipids, and specific oxygenation by cyclooxygenases, lipoxygenases and cytochrome P(450). The end-products, namely prostanoids, leukotrienes, and mono-, di- and tri-hydroxy derivatives exhibit a variety of biological effects, especially on vascular cells, leukocytes and platelets. This paper reviews some results obtained with blood platelets as target cells, showing that various lipoxygenase end-products, mainly mono- and di-hydroxy derivatives, are inhibitors (IC(50) in microM range) of arachidonic acid-induced aggregation either at the cycloxygenase or thromboxane receptor site level.
Lagarde
M
M
Université de Lyon, UMR 870 Inserm/Insa-Lyon, Villeurbanne, France. Michel.Lagarde@insa-lyon.fr
Chen
P
P
Véricel
E
E
Guichardant
M
M
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D015289:Leukotrienes / Q000378:metabolism / Q000494:pharmacology; D008084:Lipoxygenase / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D010974:Platelet Aggregation / Q000187:drug effects*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism / Q000494:pharmacology
D005231:Fatty Acids, Unsaturated; D015289:Leukotrienes; D010743:Phospholipids; D011453:Prostaglandins; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases