title: Multiphysical modelling of fluid transport through osteo-articular media.
abstract: In this study, a multiphysical description of fluid transport through osteo-articular porous media is presented. Adapted from the model of Moyne and Murad, which is intended to describe clayey materials behaviour, this multiscale modelling allows for the derivation of the macroscopic response of the tissue from microscopical information. First the model is described. At the pore scale, electrohydrodynamics equations governing the electrolyte movement are coupled with local electrostatics (Gauss-Poisson equation), and ionic transport equations. Using a change of variables and an asymptotic expansion method, the macroscopic description is carried out. Results of this model are used to show the importance of couplings effects on the mechanotransduction of compact bone remodelling.
authors.affiliation: Laboratoire de Modélisation et Simulation Multi-Echelle, Biomécanique, Université Paris Est, 61 Avenue du Général de Gaulle, Créteil, France. lemaire@univ-paris12.fr
authors.forename: Thibault
authors.initials: T
authors.lastname: Lemaire
authors.forename: Salah
authors.initials: S
authors.lastname: Naili
authors.forename: Vittorio
authors.initials: V
authors.lastname: Sansalone
mesh_terms: D001692:Biological Transport; D001696:Biomechanical Phenomena; D001826:Body Fluids / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D002358:Cartilage, Articular / Q000378:metabolism*; D008954:Models, Biological; D016062:Porosity; D055672:Static Electricity