[Systemic mycosis: factors associated with death among patients infected with the human immunodeficiency virus, Cuiabá, State of Mato Grosso, Brazil, 2005-2008].
Between 2005 and 2008, the prevalence of systemic mycosis among 1,300 HIV/AIDS patients in Cuiabá, Mato Grosso, was 4.6%. The fungus species isolated were Cryptococcus neoformans in 50%, Cryptococcus gattii in 1.6%, Cryptococcus spp in 6.6%, Histoplasma capsulatum in 38.3% and Paracoccidioides brasiliensis in 3.3%. Death was recorded in the cases of 32 patients (53.3%), and cryptococcosis was the main cause. The CD4+ T lymphocyte count was low and similar among patients who survived or died due to systemic mycosis. The factors independently associated with the deaths of these patients were alcoholism (OR: 8.2; 95% CI: 1.4-62.1; p = 0005) and the mean level of lactate dehydrogenase [758 (182) U/l vs. 416 (268) U/l; p < 0001]. The findings showed that systemic mycosis was highly lethal among the patients with HIV/AIDS in Cuiabá and suggested that clinical-laboratory characteristics such as alcoholism and early elevation of lactate dehydrogenase may be factors relating to worse prognosis under these conditions.
Ribeiro
Luciano Correa
LC
Hospital Universitário Júlio Müller, Universidade Federal do Mato Grosso, Cuiabá, MT.
Hahn
Rosane Christine
RC
Favalessa
Olivia Cometi
OC
Tadano
Tomoko
T
Fontes
Cor Jesus Fernandes
CJ
D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology / Q000401:mortality*; D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D002648:Child; D003430:Cross-Sectional Studies; D003453:Cryptococcosis / Q000401:mortality*; D005260:Female; D006660:Histoplasmosis / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010229:Paracoccidioidomycosis / Q000401:mortality*; D012307:Risk Factors; D019562:Viral Load; D055815:Young Adult