[Atypical lipomatous tumors of the stomach. Clinical, morphological and molecular findings].
Two cases of primary gastric atypical lipomatous tumors (ALT) are presented. In case No.1, a 7x4x3 cm submucosal ALT (lipoma-like subtype) of the antrum/pyloric region in a 60-year-old woman was completely resected. Using interphase dual-color-FISH, MDM2- and CDK4 amplifications could be detected in distinguished amplicons. The patient was continuously free of disease after 56 months. In case No. 2, a 3.5 cm (in diameter) submucosal ALT (lipoma-like subtype) of the gastric body in a 56-year-old woman was completely resected. FISH revealed MDM2 amplification while the CDK4 gene remained in diploid copies. This patient was continuously free of disease after 36 months. The morphologic and molecular biological findings of this rare primary gastric mesenchymal tumor are discussed in comparison with the corresponding soft tissue lesions.
Kuhnen
C
C
Institut für Pathologie am Clemenshospital, Medical Center, Düesbergweg 128, 48153 Münster. kuhnen@patho-muenster.de
Mentzel
T
T
Haarmann
W
W
Schwegler
U
U
Sciot
R
R
Debiec-Rychter
M
M
D051358:Cyclin-Dependent Kinase 4 / Q000235:genetics*; D003937:Diagnosis, Differential; D005260:Female; D005773:Gastroscopy; D005784:Gene Amplification; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D008067:Lipoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D018205:Neoplasms, Adipose Tissue / Q000235:genetics / Q000473:pathology; D051736:Proto-Oncogene Proteins c-mdm2 / Q000235:genetics*; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome
C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; D051358:Cyclin-Dependent Kinase 4