title: SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis.
abstract: Sir2 (silent information regulator-2), an NAD(+)-dependent histone deacetylase, is highly conserved in organisms ranging from archaea to humans. Yeast Sir2 is responsible for silencing at repeated DNA sequences in mating-type loci, telomeres and rDNA, and plays critical roles in DNA repair, stress resistance and longevity.The phenomenon of human aging is known to be a critical cardiovascular risk factor. Senescence of endothelial cells has been proposed to be involved in vascular dysfunction and atherogenesis. Recent studies have demonstrated that mammalian Sirt1 NAD(+)-dependent protein deacetylase, the closest homologue of Sir2, regulates vascular angiogenesis, homeostasis and senescence. This review focuses on SIRT1 as a potential therapeutic target against atherosclerosis.
authors.affiliation: Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Ota
authors.forename: Masato
authors.initials: M
authors.lastname: Eto
authors.forename: Sumito
authors.initials: S
authors.lastname: Ogawa
authors.forename: Katsuya
authors.initials: K
authors.lastname: Iijima
authors.forename: Masahiro
authors.initials: M
authors.lastname: Akishita
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Ouchi
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D050197:Atherosclerosis / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D000077407:Cilostazol; D006706:Homeostasis; D006801:Humans; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism*; D018384:Oxidative Stress; D056564:Sirtuin 1 / Q000378:metabolism*; D013777:Tetrazoles / Q000494:pharmacology*; D015854:Up-Regulation
chemical_list: D013777:Tetrazoles; D052250:Nitric Oxide Synthase Type III; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D000077407:Cilostazol