title: Effects of additional administration of low-dose indapamide on patients with hypertension treated with angiotensin II receptor blocker.
abstract: BACKGROUND
  Low-dose thiazide or thiazide-like diuretics have proven useful for the management of blood pressure in patients older than 65 years (elderly group). However, there are few reports about the antihypertensive effects of antihypertensive diuretic agents in patients younger than 65 years (middle-aged group). So, we evaluated the efficacy of low-dose indapamide on blood pressure.
  
  
  METHODS
  Indapamide(1 mg) was given daily for 3 months and was then given every other day for 3 months to patients whose hypertension was poorly controlled with angiotensin II receptor blocker (ARB)-based treatment.
  
  
  RESULTS
  After daily administration of indapamide, blood pressure was significantly decreased in both the middle-aged and elderly groups. Blood pressure was not significantly changed by every-other-day administration compared with that observed after daily administration in either group. The rate of attainment of the target blood pressure was 90.3% and 85.7% in the middle-aged and elderly groups, respectively. The serum uric acid levels were reduced after every-other-day administration compared to daily administration but tended to be higher than the levels at the baseline in both groups.
  
  
  CONCLUSIONS
  The addition of low-dose indapamide is a useful strategy for the management of hypertension, as it reduced blood pressure without marked side effects.
authors.affiliation: Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan. yamadah@clin.med.tokushima-u.ac.jp
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Yamada
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Mishiro
authors.forename: Kenya
authors.initials: K
authors.lastname: Kusunose
authors.forename: Masataka
authors.initials: M
authors.lastname: Sata
mesh_terms: D000367:Age Factors; D000368:Aged; D057912:Angiotensin II Type 2 Receptor Blockers; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure; D004232:Diuretics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007190:Indapamide / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood
chemical_list: D057912:Angiotensin II Type 2 Receptor Blockers; D000959:Antihypertensive Agents; D004232:Diuretics; D014527:Uric Acid; D007190:Indapamide