A possible role for the striatum in the pathogenesis of the cognitive symptoms of schizophrenia.
The cognitive symptoms of schizophrenia are largely resistant to current treatment and are thus a life-long burden of the illness. Studies of cognitive symptoms have commonly focused on prefrontal cortex because of its demonstrated importance for executive function and working memory--key components of the deficit. The role of striatal-cortical circuitry and therefore the striatum itself has received much less attention. Here we review longstanding evidence that the striatum and its cortical connections are critical for complex cognition and discuss emerging evidence of the striatum's potential involvement in cognitive symptoms. Finally, we suggest how mouse models might test ideas about the contribution of early striatal dysfunction to the cognitive symptoms of schizophrenia.
Simpson
Eleanor H
EH
Department of Psychiatry, Columbia University and New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY 10032, USA. es534@columbia.edu
Kellendonk
Christoph
C
Kandel
Eric
E
D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology*; D003342:Corpus Striatum / Q000503:physiopathology*; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D051379:Mice; D008954:Models, Biological; D009434:Neural Pathways / Q000503:physiopathology; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology
D004298:Dopamine