Integrated intravascular optical coherence tomography ultrasound imaging system.
We report on a dual-modality optical coherence tomography (OCT) ultrasound (US) system for intravascular imaging. To the best of our knowledge, we have developed the first integrated OCT-US probe that combines OCT optical components with an US transducer. The OCT optical components mainly consist of a single-mode fiber, a gradient index lens for light-beam focusing, and a right-angled prism for reflecting light into biological tissue. A 40-MHz piezoelectric transducer (PZT-5H) side-viewing US transducer was fabricated to obtain the US image. These components were integrated into a single probe, enabling both OCT and US imaging at the same time. In vitro OCT and ultrasound images of a rabbit aorta were obtained using this dual-modality imaging system. This study demonstrates the feasibility of an OCT-US system for intravascular imaging, which is expected to have a prominent impact on early detection and characterization of atherosclerosis.
Yin
Jiechen
J
Yang
Hao-Chung
HC
Li
Xiang
X
Zhang
Jun
J
Zhou
Qifa
Q
Hu
Changhong
C
Shung
K Kirk
KK
Chen
Zhongping
Z
D000818:Animals; D001011:Aorta / Q000033:anatomy & histology; D004867:Equipment Design; D011817:Rabbits; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000295:instrumentation* / Q000379:methods*