Ectopic and high CXCL13 chemokine expression in myasthenia gravis with thymic lymphoid hyperplasia.
Myasthenia gravis (MG) is an antibody and complement mediated autoimmune disease. Serum CXC chemokine ligand 13 (CXCL13) was found to be elevated in MG patients and high CXCL13 level was associated with severe clinical stages, especially in females with thymic lymphoid hyperplasia. Both protein and mRNA of CXCL13 and CXC chemokine receptor 5 (CXCR5) in the thymic tissues were significantly higher in MG patients with lymphoid hyperplasia than those with thymoma. Our data indicated that serum CXCL13 can be used as an index of disease severity and ectopic thymic expression of CXCL13 might be associated with aberrant cell trafficking to the thymus of MG.
Shiao
Yu-Ming
YM
Faculty of Life Sciences, National Yang-Ming University, Taipei, Taiwan.
Lee
Chin-Cheng
CC
Hsu
Yung-Hsiang
YH
Huang
Shiu-Feng
SF
Lin
Chung-Yen
CY
Li
Ling-Hui
LH
Fann
Cathy S-J
CS
Tsai
Chang-Youh
CY
Tsai
Shih-Feng
SF
Chiu
Hou-Chang
HC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D054382:Chemokine CXCL13 / Q000235:genetics / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D012333:RNA, Messenger / Q000378:metabolism; D054380:Receptors, CXCR5 / Q000235:genetics / Q000378:metabolism; D012737:Sex Factors; D013950:Thymus Gland / Q000276:immunology / Q000378:metabolism*; D013952:Thymus Hyperplasia / Q000150:complications* / Q000378:metabolism* / Q000473:pathology; D055815:Young Adult
C095085:CXCR5 protein, human; D054382:Chemokine CXCL13; D012333:RNA, Messenger; D054380:Receptors, CXCR5