Recent advances in pharmacokinetics of polymeric excipients used in nanosized anti-cancer drugs.
The efficacy of drug delivery systems using nanoparticles to enhance the pharmacokinetic properties of drugs has been confirmed in both preclinical trials and clinical settings. A nanosized drug system has improved efficacy, reduced side effects and clearance, increased cellular uptake and prolonged time in circulation. This article will focus recent studies of the pharmacokinetic behavior of such systems as poly(ethylene glycol) and polyamidoamine. Their derivatives are also analyzed. Additionally, some diseases with very good responsiveness are aslo reported.
Cuong
Nguyen-Van
NV
Department of Biomedical Engineering and R&D Center for Biomedical Microdevice Technology, Chung Yuan Christian University, Chung Li, Taiwan, Republic of China.
Hsieh
Ming-Fa
MF
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D050091:Dendrimers / Q000737:chemistry / Q000493:pharmacokinetics; D004304:Dosage Forms; D004337:Drug Carriers / Q000737:chemistry / Q000493:pharmacokinetics; D004354:Drug Screening Assays, Antitumor; D005079:Excipients / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy; D011092:Polyethylene Glycols / Q000737:chemistry / Q000493:pharmacokinetics; D011108:Polymers / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use
D000970:Antineoplastic Agents; D050091:Dendrimers; D004304:Dosage Forms; D004337:Drug Carriers; D005079:Excipients; C104700:PAMAM Starburst; D011108:Polymers; D011092:Polyethylene Glycols