Effect of transient forebrain ischemia on flavoprotein autofluorescence and the somatosensory evoked potential in the rat.
In order to evaluate the effect of cerebral ischemia on the flavoprotein fluorescence (FPF), we compared the changes in the FPF and somatosensory evoked potential (SEP) during transient cerebral ischemia in the rat. We measured the FPF and SEP simultaneously via a cranial window made over the right sensorimotor cortex during the left median nerve stimulation in F344 rats. We compared change in FPF and SEP during cerebral ischemia for 60 min. The rCBF were rapidly recovered after reperfusion. However, the recovery rates of the FPF were significantly faster than those of the SEP after reperfusion. These findings indicate that activity-dependent changes of the FPF do not necessarily correlate with the electrical activity after transient cerebral ischemia.
Igarashi
Takahiro
T
Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, Tokyo 173-8610, Japan.
Sakatani
Kaoru
K
Hoshino
Tatsuya
T
Fujiwara
Norio
N
Murata
Yoshihiro
Y
Kano
Tsuneo
T
Kojima
Jun
J
Yamamoto
Takamitsu
T
Katayama
Yoichi
Y
D000818:Animals; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005420:Flavoproteins / Q000378:metabolism*; D005453:Fluorescence; D002546:Ischemic Attack, Transient / Q000150:complications / Q000503:physiopathology*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D015427:Reperfusion Injury / Q000150:complications / Q000503:physiopathology
D005420:Flavoproteins