title: Photothermal optical coherence tomography in ex vivo human breast tissues using gold nanoshells.
abstract: We demonstrate photothermal optical coherence tomography (OCT) imaging in highly scattering human breast tissue ex vivo. A 120 kHz axial scan rate, swept-source phase-sensitive OCT system at 1300 nm was used to detect phase changes induced by 830 nm photothermal excitation of gold nanoshells. Localized phase modulation was observed 300-600 microm deep in scattering tissue using an excitation power of only 22 mW at modulation frequencies up to 20 kHz. This technique enables integrated structural and molecular-targeted imaging for cancer markers using nanoshells.
authors.affiliation: Department of Electrical Engineering and Computer Science and Research Laboratory of Electronics, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Chao
authors.initials: C
authors.lastname: Zhou
authors.forename: Tsung-Han
authors.initials: TH
authors.lastname: Tsai
authors.forename: Desmond C
authors.initials: DC
authors.lastname: Adler
authors.forename: Hsiang-Chieh
authors.initials: HC
authors.lastname: Lee
authors.forename: David W
authors.initials: DW
authors.lastname: Cohen
authors.forename: Amy
authors.initials: A
authors.lastname: Mondelblatt
authors.forename: Yihong
authors.initials: Y
authors.lastname: Wang
authors.forename: James L
authors.initials: JL
authors.lastname: Connolly
authors.forename: James G
authors.initials: JG
authors.lastname: Fujimoto
mesh_terms: D001940:Breast / Q000166:cytology*; D003287:Contrast Media / Q000737:chemistry*; D005260:Female; D006046:Gold / Q000737:chemistry; D006358:Hot Temperature; D006801:Humans; D066298:In Vitro Techniques; D015336:Molecular Probe Techniques; D053758:Nanoparticles / Q000737:chemistry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D003287:Contrast Media; D006046:Gold