Interrelationships between paraoxonase-1 and monocyte chemoattractant protein-1 in the regulation of hepatic inflammation.
Oxidative stress and inflammation play a central role in the onset and development of liver diseases irrespective of the agent causing the hepatic impairment. The monocyte chemoattractant protein-1 is intimately involved in the inflammatory reaction and is directly correlated with the degree of hepatic inflammation in patients with chronic liver disease. Recent studies showed that hepatic paraoxonase-1 may counteract the production of the monocyte chemoattractant protein-1, thus playing an anti-inflammatory role. The current review summarises experiments suggesting how paraoxonase-1 activity and expression are altered in liver diseases, and their relationships with the monocyte chemoattractant protein-1 and inflammation.
Camps
Jordi
J
Centre de Recerca Biomèdica, Hospital Universitari de Sant Joan, C. Sant Joan s/n, 43201-Reus, Catalunya, Spain. jcamps@grupsagessa.cat
Marsillach
Judit
J
Rull
Anna
A
Alonso-Villaverde
Carlos
C
Joven
Jorge
J
D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D043303:Aryldialkylphosphatase / Q000378:metabolism*; D018932:Chemokine CCL2 / Q000378:metabolism*; D005355:Fibrosis / Q000473:pathology; D006801:Humans; D007249:Inflammation; D008099:Liver / Q000378:metabolism / Q000473:pathology*; D008954:Models, Biological; D018384:Oxidative Stress; D047495:PPAR gamma / Q000378:metabolism; D011994:Recombinant Proteins / Q000737:chemistry
D000893:Anti-Inflammatory Agents; D018932:Chemokine CCL2; D047495:PPAR gamma; D011994:Recombinant Proteins; D043303:Aryldialkylphosphatase