title: Evaluation of serum levels of C-reactive protein and lipid profiles in patients with chronic periodontitis and/or coronary heart disease in an ethnic Han population.
abstract: OBJECTIVE
  To investigate the relationship of coronary heart disease (CHD)-associated factors-C-reactive protein (CRP) and lipid profiles-with periodontitis in an ethnic Han population.
  
  
  METHODS
  Forty healthy individuals as control, 40 patients with chronic periodontitis (CP), 28 patients with CHD, and 47 patients with both CP and CHD were included in the study. Serum CRP levels, lipid profile concentrations, and three periodontal clinical parameters (probing depth, clinical attachment level, and bleeding on probing) were measured and analyzed. The chi-square test, Student-Newman-Keuls test, analysis of covariance, and a logistic regression analysis were used in this study.
  
  
  RESULTS
  The mean CRP level of patients with CP alone was 2.4 +/- 1.5 mg/L. There were significant differences in mean serum CRP levels among groups after confounders were adjusted, with CP+CHD patients having the highest level (7.3 +/- 5.7 mg/L) and the controls the lowest (1.0 +/- 0.6 mg/L) (P < .001). Mean HDL cholesterol level of CP patients (1.1 +/- 0.7 mmol/L) was significantly lower than that of controls (1.4 +/- 0.6 mmol/L) (P < .05), although it was significantly higher than that of the other two groups with CHD (0.8 +/- 0.5 mmol/L and 0.7 +/- 0.4 mmol/L) (P < .001). Significant correlations of CRP and HDL cholesterol with the three clinical periodontal parameters were apparent (P < .05). CRP and HDL cholesterol were found to be significantly associated with an increased frequency of CHD in this regression model (OR = 3.7 and OR = 1.9, respectively, P < .05).
  
  
  CONCLUSIONS
  In an ethnic Han population with a low normal range of serum CRP levels, chronic periodontitis is associated with increased CRP levels and decreased HDL cholesterol concentrations, which suggests that there may be some relationship between periodontal inflammation and CHD.
authors.affiliation: Department of Periodontology, Dental Hospital, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.forename: Yafei
authors.initials: Y
authors.lastname: Wu
authors.forename: Yi
authors.initials: Y
authors.lastname: Ding
authors.forename: Sui
authors.initials: S
authors.lastname: Meng
authors.forename: Song
authors.initials: S
authors.lastname: Ge
authors.forename: Hui
authors.initials: H
authors.lastname: Deng
mesh_terms: D044466:Asian People; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D055113:Chronic Periodontitis / Q000097:blood* / Q000150:complications; D003327:Coronary Disease / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010512:Periodontal Index; D012923:Social Class; D018709:Statistics, Nonparametric; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002097:C-Reactive Protein