Exploring neoglycoprotein assembly through native chemical ligation using neoglycopeptide thioesters prepared via N-->S acyl transfer.
Sugars and simplified oligosaccharide "mimics" can be joined with protein fragments at pre-defined sites using reliable chemical reactions such as thiol alkylation and Cu(I) catalysed azide/acetylene ligation (click chemistry). These fragments have the potential to be assembled into neoglycoprotein therapeutics using native chemical ligation.
Richardson
Jonathan P
JP
Department of Chemistry, University College London, 20 Gordon Street, London, WC1H 0AJ, UK.
Chan
Chung-Hei
CH
Blanc
Javier
J
Saadi
Mona
M
Macmillan
Derek
D
D000595:Amino Acid Sequence; D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry; D006020:Glycopeptides / Q000737:chemistry*; D006023:Glycoproteins / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009584:Nitrogen / Q000737:chemistry*; D009844:Oligosaccharides / Q000737:chemistry; D011487:Protein Conformation; D013379:Substrate Specificity; D013455:Sulfur / Q000737:chemistry*
D006020:Glycopeptides; D006023:Glycoproteins; D009844:Oligosaccharides; D013455:Sulfur; D009584:Nitrogen