[Intraocular lens and bacterial adhesion: influence of the environmental factors, the characteristics of the bacteria, and the target material surface].
Adhesion of bacteria to intraocular lenses is an important step in the pathogenesis of postoperative endophthalmitis. It can be described as a two-phase process including an initial, instantaneous, and reversible phase followed by a time-dependant and irreversible molecular and cellular phase. The binding of bacteria is affected by many factors including environmental factors such as medium composition, presence of proteins and flow conditions, the bacterial cell surface characteristics, and the material's surface properties. This article reviews all these factors affecting the adhesion of bacteria to intraocular lenses. A better understanding of these mechanisms would make it possible to reduce the bacterial adhesion process and thus could help decrease the incidence of postoperative endophthalmitis.
Baillif
S
S
Département d'Ophtalmologie, Centre hospitalo-universitaire Saint Roch, Nice, France; Laboratoire "Réparation Tissulaire, Interactions Biologiques et Biomatériaux", UPSP 2007.03.135 RTI2B, Lyon, France.
Hartmann
D
D
Freney
J
J
Kodjikian
L
L
D001422:Bacterial Adhesion; D001672:Biocompatible Materials; D018441:Biofilms; D001826:Body Fluids; D055598:Chemical Phenomena; D009877:Endophthalmitis / Q000209:etiology / Q000382:microbiology*; D004866:Equipment Contamination; D005136:Eye Proteins / Q000502:physiology; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular / Q000382:microbiology*; D011183:Postoperative Complications / Q000209:etiology / Q000382:microbiology*; D013212:Staphylococcus epidermidis / Q000502:physiology; D013499:Surface Properties
D001672:Biocompatible Materials; D005136:Eye Proteins