Persistent symptoms in mild to moderate traumatic brain injury associated with executive dysfunction.
In order to improve detection of subtle cognitive dysfunction and to shed light on the etiology of persistent symptoms after mild-to-moderate traumatic brain injury (TBI), we employed an experimental executive reaction time (RT) test, standardized neuropsychological tests, and diffusion tensor imaging (DTI). The Executive RT-Test, an Executive Composite Score from standardized neuropsychological tests, and DTI-indices in the midbrain differentiated between patients with persistent symptoms from those fully recovered after mild-to-moderate TBI. We suggest that persistent symptoms in mild-to-moderate TBI may reflect disrupted fronto-striatal network involved in executive functioning, and the Executive RT-Test provides an objective and novel method to detect it.
Hartikainen
Kaisa M
KM
Department of Neurology, Tampere University Hospital, Tampere, Finland. kaisa.hartikainen@pshp.fi
Waljas
Minna
M
Isoviita
Tuulia
T
Dastidar
Prasun
P
Liimatainen
Suvi
S
Solbakk
Anne-Kristin
AK
Ogawa
Keith H
KH
Soimakallio
Seppo
S
Ylinen
Aarne
A
Ohman
Juha
J
D000328:Adult; D001921:Brain / Q000473:pathology; D001930:Brain Injuries / Q000473:pathology / Q000523:psychology*; D003071:Cognition / Q000502:physiology; D003863:Depression / Q000209:etiology / Q000523:psychology; D038524:Diffusion Magnetic Resonance Imaging; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000209:etiology / Q000523:psychology; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time / Q000502:physiology; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D055815:Young Adult