Synthesis and biological evaluations of novel bendazac lysine analogues as potent anticataract agents.
Novel bendazac analogues and their salts have been designed and prepared. The resulting compounds (13c-d, 15c, 17c) showed very good aqueous solubility (>100 mg/mL). An in vitro assay showed that most of the resulting compounds had potent protective activity against the oxidative damage. Particularly, compound 13d was also able to enhance the WSP and T-AOC level in the H(2)O(2)/FeCl(3)-induced oxidative damage model, indicating the resulting compound may protect the lens through an antioxidant pathway.
Shen
Hong
H
School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China.
Gou
Shaohua
S
Shen
Jianping
J
Zhu
Yanqin
Y
Zhang
Yindi
Y
Chen
Xuetai
X
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002386:Cataract / Q000188:drug therapy / Q000517:prevention & control*; D007191:Indazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007908:Lens, Crystalline / Q000187:drug effects / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D012995:Solubility
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D007191:Indazoles; C036067:bendazac lysine