title: Effects of neurotensin in amygdaloid spatial learning mechanisms.
abstract: Neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reward related processes. The central nucleus of amygdala (CeA) participates in the regulation of memory and learning mechanisms. In Morris water maze test, rats were microinjected with NT or neurotensin receptor-1 (NTS1) antagonist SR 48692 (ANT). NT significantly reduced the escape latency. Effect of NT was blocked by ANT pretreatment. Our results show that in the rat CeA NT facilitates spatial learning. We clarified that NTS1s are involved in this action.
authors.affiliation: Institute of Physiology, Pécs University Medical School, Pécs, Hungary.
authors.forename: Kristóf
authors.initials: K
authors.lastname: László
authors.forename: Krisztián
authors.initials: K
authors.lastname: Tóth
authors.forename: Erika
authors.initials: E
authors.lastname: Kertes
authors.forename: László
authors.initials: L
authors.lastname: Péczely
authors.forename: Tamás
authors.initials: T
authors.lastname: Ollmann
authors.forename: László
authors.initials: L
authors.lastname: Lénárd
mesh_terms: D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D004347:Drug Interactions; D008297:Male; D009496:Neurotensin / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D018028:Receptors, Neurotensin / Q000037:antagonists & inhibitors; D013028:Space Perception / Q000187:drug effects*; D018709:Statistics, Nonparametric
chemical_list: D011720:Pyrazoles; D011804:Quinolines; D018028:Receptors, Neurotensin; C079087:SR 48692; D009496:Neurotensin