Failures of feedback: rush hour along the highway to obesity.
From hot dogs to Hashimoto's and inheritance to inactivity, many "entrance ramps" converge onto the "Highway to Obesity", each contributing caloric intake that exceeds expenditure. Initially, the hypothalamus regulates appetite and energy based on leptin feedback, until feedback failure increases appetite, and allows deposition of abdominal fat, metabolic dysregulation, and metabolic syndrome. Without feedback controls, progress toward obesity is unimpeded unless diet, exercise, and/or medications provide an exit ramp.
Gade
Wayne
W
Clinical Laboratory Science Department, HSB Rm 314, One University Place, Springfield, IL 62703, USA. wgade1@uis.edu
Gade
Jean
J
Collins
Melissa
M
Schmit
Jessica
J
Schupp
Nicole
N
D000328:Adult; D000818:Animals; D025461:Feedback, Physiological; D020022:Genetic Predisposition to Disease; D006801:Humans; D020738:Leptin / Q000502:physiology; D009765:Obesity / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy
D020738:Leptin