title: Brønsted acid-catalyzed efficient Strecker reaction of ketones, amines and trimethylsilyl cyanide.
abstract: A general method for the one-pot, three-component Strecker reaction of ketones was developed using Brønsted acids as organocatalysts. A series of alpha-aminonitriles were obtained in good to excellent yields (79-99%). A preliminary extension to a catalytic enantioselective three-component Strecker reaction of ketones (up to 40% ee) is also described.
authors.affiliation: Department of Chemistry, Tianjin University, Tianjin 300072, China.
authors.forename: Guang-Wu
authors.initials: GW
authors.lastname: Zhang
authors.forename: Dong-Hua
authors.initials: DH
authors.lastname: Zheng
authors.forename: Jing
authors.initials: J
authors.lastname: Nie
authors.forename: Teng
authors.initials: T
authors.lastname: Wang
authors.forename: Jun-An
authors.initials: JA
authors.lastname: Ma
mesh_terms: D000143:Acids / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
chemical_list: D000143:Acids; D000588:Amines; D003486:Cyanides; D007659:Ketones; D014297:Trimethylsilyl Compounds; C058010:trimethylsilyl cyanide