[Anti-apoptotic mechanisms in small-cell lung carcinoma].
Small-cell lung carcinomas account for about 15-20% of lung cancer and are characterized by an intrinsic resistance to apoptosis. Increasing evidence suggests that alteration in apoptosis/antiapoptosis balance could lead to fundamental resistance of small-cell lung cancer to chemotherapy and radiation. These molecular alterations include alteration of mitochondrial pathways (BCL2 and BCLXL overexpression, activation of stress protein such as HSP 90 and HSP70, activation of PI3K/AKT/mTOR pathway). Others abnormalities could inhibit activation of extrinsic pathway such as caspase-8 and FAS underexpression as well as C-FLIP overexpression. New therapies targeting some of these abnormalities are under clinical evaluation and predictive factors of response are needed to personalize these therapies.
Loriot
Yohann
Y
Département de médecine, institut Gustave-Roussy, 39 rue Camille-Desmoulins, Villejuif, France. yohann.loriot@igr.fr
Calderaro
Julien
J
Soria
Jean-Charles
JC
Deutsch
Eric
E
Vielh
Philippe
P
D017209:Apoptosis / Q000502:physiology*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D055752:Small Cell Lung Carcinoma / Q000473:pathology*