title: MicroRNAs--targeting and target prediction.
abstract: MicroRNAs (miRNAs) are a class of small noncoding RNAs that can regulate many genes by base pairing to sites in mRNAs. The functionality of miRNAs overlaps that of short interfering RNAs (siRNAs), and many features of miRNA targeting have been revealed experimentally by studying miRNA-mimicking siRNAs. This review outlines the features associated with animal miRNA targeting and describes currently available prediction tools.
authors.affiliation: Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO-7489 Trondheim, Norway.
authors.forename: Takaya
authors.initials: T
authors.lastname: Saito
authors.forename: Pal
authors.initials: P
authors.lastname: Saetrom
mesh_terms: D020413:3' Untranslated Regions; D000818:Animals; D001483:Base Sequence; D018390:Gene Targeting; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism
chemical_list: D020413:3' Untranslated Regions; D035683:MicroRNAs; D034741:RNA, Small Interfering