title: An atlas of combinatorial transcriptional regulation in mouse and man.
abstract: Combinatorial interactions among transcription factors are critical to directing tissue-specific gene expression. To build a global atlas of these combinations, we have screened for physical interactions among the majority of human and mouse DNA-binding transcription factors (TFs). The complete networks contain 762 human and 877 mouse interactions. Analysis of the networks reveals that highly connected TFs are broadly expressed across tissues, and that roughly half of the measured interactions are conserved between mouse and human. The data highlight the importance of TF combinations for determining cell fate, and they lead to the identification of a SMAD3/FLI1 complex expressed during development of immunity. The availability of large TF combinatorial networks in both human and mouse will provide many opportunities to study gene regulation, tissue differentiation, and mammalian evolution.
authors.affiliation: The FANTOM Consortium, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
authors.forename: Timothy
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authors.lastname: Ravasi
authors.forename: Harukazu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Carlo Vittorio
authors.initials: CV
authors.lastname: Cannistraci
authors.forename: Shintaro
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authors.lastname: Katayama
authors.forename: Vladimir B
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authors.lastname: Bajic
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authors.forename: Altuna
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authors.lastname: Akalin
authors.forename: Sebastian
authors.initials: S
authors.lastname: Schmeier
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Kanamori-Katayama
authors.forename: Nicolas
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authors.lastname: Bertin
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authors.forename: Alistair R R
authors.initials: AR
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authors.forename: Julian
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authors.lastname: Gough
authors.forename: Sean
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authors.lastname: Grimmond
authors.forename: Jung-Hoon
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authors.lastname: Han
authors.forename: Takehiro
authors.initials: T
authors.lastname: Hashimoto
authors.forename: Winston
authors.initials: W
authors.lastname: Hide
authors.forename: Oliver
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authors.lastname: Hofmann
authors.forename: Atanas
authors.initials: A
authors.lastname: Kamburov
authors.forename: Mandeep
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authors.lastname: Kaur
authors.forename: Hideya
authors.initials: H
authors.lastname: Kawaji
authors.forename: Atsutaka
authors.initials: A
authors.lastname: Kubosaki
authors.forename: Timo
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authors.lastname: Lassmann
authors.forename: Erik
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authors.lastname: van Nimwegen
authors.forename: Cameron Ross
authors.initials: CR
authors.lastname: MacPherson
authors.forename: Chihiro
authors.initials: C
authors.lastname: Ogawa
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Radovanovic
authors.forename: Ariel
authors.initials: A
authors.lastname: Schwartz
authors.forename: Rohan D
authors.initials: RD
authors.lastname: Teasdale
authors.forename: Jesper
authors.initials: J
authors.lastname: Tegnér
authors.forename: Boris
authors.initials: B
authors.lastname: Lenhard
authors.forename: Sarah A
authors.initials: SA
authors.lastname: Teichmann
authors.forename: Takahiro
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authors.lastname: Arakawa
authors.forename: Noriko
authors.initials: N
authors.lastname: Ninomiya
authors.forename: Kayoko
authors.initials: K
authors.lastname: Murakami
authors.forename: Michihira
authors.initials: M
authors.lastname: Tagami
authors.forename: Shiro
authors.initials: S
authors.lastname: Fukuda
authors.forename: Kengo
authors.initials: K
authors.lastname: Imamura
authors.forename: Chikatoshi
authors.initials: C
authors.lastname: Kai
authors.forename: Ryoko
authors.initials: R
authors.lastname: Ishihara
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Kitazume
authors.forename: Jun
authors.initials: J
authors.lastname: Kawai
authors.forename: David A
authors.initials: DA
authors.lastname: Hume
authors.forename: Trey
authors.initials: T
authors.lastname: Ideker
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Hayashizaki
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019143:Evolution, Molecular; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006801:Humans; D051379:Mice; D009000:Monocytes / Q000166:cytology; D009928:Organ Specificity; D051900:Smad3 Protein / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D051900:Smad3 Protein; D015534:Trans-Activators; D014157:Transcription Factors