title: Production and stability evaluation of modified-release microparticles for the delivery of drug combinations.
abstract: Production and evaluation of novel formulations of tizanidine and tramadol microparticles was the chief purpose of this project. Microparticles of both drugs were prepared separately via temperature change method. To extend the release of formulations, ethyl cellulose was employed. Higuchi, zero-order, first-order, and Korsmeyer-Peppas kinetic models were applied to appraise the mechanism and mode of drugs release. Higuichi model was found to be best for all release profiles. Stability of microparticles at 40 degrees C/75% RH over a 3-month duration was determined by Fourier transform infrared (FTIR), X-ray diffractometry (XRD), and drugs assay. Microparticles were compatible and stable as no significant differences were observed when subjected to drug assay, FTIR, and XRD during accelerated stability studies.
authors.affiliation: Faculty of Pharmacy & Alternative Medicine, The Islamia University of Bahawalpur, Punjab, Pakistan. mna19bwp@yahoo.com
authors.forename: Muhammad Naeem
authors.initials: MN
authors.lastname: Aamir
authors.forename: Mahmood
authors.initials: M
authors.lastname: Ahmad
mesh_terms: D002482:Cellulose / Q000031:analogs & derivatives; D002626:Chemistry, Pharmaceutical; D004338:Drug Combinations; D007700:Kinetics; D013696:Temperature; D014965:X-Rays
chemical_list: D004338:Drug Combinations; C013517:ethyl cellulose; D002482:Cellulose