CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis.
Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immunological adjuvants, alum and monophosphoryl lipid A.
Bhagawati-Prasad
Vijay Ns
VN
Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
De Leenheer
Evy
E
Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
Keefe
Nadine P
NP
Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
Ryan
Lorna A
LA
Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
Carlring
Jennifer
J
Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
Heath
Andrew W
AW
Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.|Adjuvantix Ltd, c/o Fusion plc, Sheffield Bioincubator, Leavygreave Rd, Sheffield, UK.