In vitro effect of octyl - methoxycinnamate (OMC) on the release of Gn-RH and amino acid neurotransmitters by hypothalamus of adult rats.
OMC (octyl-methoxycinnamate), an endocrine disruptor having estrogenic activity, is used in sunscreen creams as UV filter. We studied its "in vitro" effects on the hypothalamic release of Gn-RH as well as on the amino acid neurotransmitter system. OMC significantly decreased Gn-RH release in normal male and female rats as well as in castrated rats with substitutive therapy. No effects were observed in castrated rats without substitutive therapy. In males OMC increases the release of GABA, decreasing the production of glutamate (GLU) while in the female decreases the excitatory amino acid aspartate (ASP) and GLU without modifications in the hypothalamic GABA release. These results suggest that OMC acting as endocrine disruptor could alter the sex hormone-neurotransmitter-Gn-RH axis relationships in adult rats.
Carbone
S
S
Departamento de Fisiología, Universidad de Buenos Aires, Argentina.
Szwarcfarb
B
B
Reynoso
R
R
Ponzo
O J
OJ
Cardoso
N
N
Ale
E
E
Moguilevsky
J A
JA
Scacchi
P
P
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D002934:Cinnamates / Q000494:pharmacology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D012727:Sex Characteristics; D013473:Sunscreening Agents / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000596:Amino Acids; D002934:Cinnamates; D013473:Sunscreening Agents; D001224:Aspartic Acid; D007987:Gonadotropin-Releasing Hormone; C118580:octylmethoxycinnamate; D005680:gamma-Aminobutyric Acid