title: TAP1 and TAP2 gene polymorphisms in childhood cystic echinococcosis.
abstract: The incidence of cystic echinococcosis (CE) due to Echinococcus granulosus is as high as 2000-2500 patients per year in Turkey. Whether genetic characteristics of the Turkish population cause a tendency to the disease is currently unknown. We aimed at studying the role of TAP gene polymorphisms in Turkish children with cystic echinococcosis. For an overview of allelic distribution of TAP1 and TAP2 genes, genotypes of 85 patients with CE and 100 controls were studied. To determine the genotype-phenotype correlation, 81 of the patients whose clinical data were available were analyzed. For TAP1-637, Asp/Gly heterozygosity was significantly more prevalent in CE patients than in controls (20 vs. 4%, odds ratio 6.0), while Gly/Gly homozygosity was less frequent (5 vs. 14%). For TAP2-379, Ile/Val heterozygosity was significantly more prevalent in CE patients than in controls (14 vs. 1%, odds ratio 16.27), while Ile/Ile homozygosity was less frequent (13 vs. 25%). TAP1-637 and TAP2-379 polymorphisms may have a role in causing genetic tendency for CE in children. The data may reflect the genetic properties of the Turkish population or may reveal the minor role of TAP gene polymorphisms in CE.
authors.affiliation: Hacettepe University, Department of Pediatrics, Chest Diseases Unit, Ankara, Turkey. nkiper@hacettepe.edu.tr
authors.forename: Nural
authors.initials: N
authors.lastname: Kiper
authors.forename: Filiz
authors.initials: F
authors.lastname: Gerçeker
authors.forename: Eda
authors.initials: E
authors.lastname: Utine
authors.forename: Ebru
authors.initials: E
authors.lastname: Yalçin
authors.forename: Sevgi
authors.initials: S
authors.lastname: Pekcan
authors.forename: Nazan
authors.initials: N
authors.lastname: Cobanoğlu
authors.forename: Ayşe
authors.initials: A
authors.lastname: Aslan
authors.forename: Mehmet
authors.initials: M
authors.lastname: Köse
authors.forename: Deniz
authors.initials: D
authors.lastname: Doğru
authors.forename: Uğur
authors.initials: U
authors.lastname: Ozçelik
authors.forename: Meral
authors.initials: M
authors.lastname: Ozgüç
mesh_terms: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D002675:Child, Preschool; D004443:Echinococcosis / Q000453:epidemiology / Q000235:genetics* / Q000469:parasitology; D048209:Echinococcus granulosus; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D015995:Prevalence; D014421:Turkey / Q000453:epidemiology
chemical_list: D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; C073119:TAP1 protein, human; C071692:TAP2 protein, human