title: Cellular blue nevus (CBN) lymph node metastases of the neck with no primary skin lesion: a case report and review of literature.
abstract: A case of cervical lymph node infiltration by a benign cellular blue nevus (CBN) and a 27-year disease history is presented. Dermal dendritic melanocytes and pigmented spindle cells presented no histological evidence of malignancy (CD34-, desmin-, PanCy-, HMB-45+, anti-S-100+, Bcl-2+, MART-1+, focally expression of melan A, 1% Ki-67+ of the tumour cell nucleoli). The differentiation of the benign blue nevus (BN) from a malignant blue nevus (MBN) and a malignant melanoma (MM) is still a challenge. Because of the malignant transformation potential of 5.2-6.3% a histological examination and a conservative surgical approach with close follow up are mandatory.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Martin-Luther-University Halle-Wittenberg, Germany.
authors.forename: Konstanze
authors.initials: K
authors.lastname: Scheller
authors.forename: Christian
authors.initials: C
authors.lastname: Scheller
authors.forename: Susann
authors.initials: S
authors.lastname: Becker
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Holzhausen
authors.forename: Johannes
authors.initials: J
authors.lastname: Schubert
mesh_terms: D003937:Diagnosis, Differential; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000473:pathology; D008875:Middle Aged; D009333:Neck; D018329:Nevus, Blue / Q000473:pathology* / Q000601:surgery; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome