Spatio-temporal epidemiology of Campylobacter jejuni enteritis, in an area of Northwest England, 2000-2002.
A total of 969 isolates of Campylobacter jejuni originating in the Preston, Lancashire postcode district over a 3-year period were characterized using multi-locus sequence typing. Recently developed statistical methods and a genetic model were used to investigate temporal, spatial, spatio-temporal and genetic variation in human C. jejuni infections. The analysis of the data showed statistically significant seasonal variation, spatial clustering, small-scale spatio-temporal clustering and spatio-temporal interaction in the overall pattern of incidence, and spatial segregation in cases classified according to their most likely species-of-origin.
Gabriel
E
E
Lancaster University, Lancaster, UK. edith.gabriel@univ-avignon.fr
Wilson
D J
DJ
Leatherbarrow
A J H
AJ
Cheesbrough
J
J
Gee
S
S
Bolton
E
E
Fox
A
A
Fearnhead
P
P
Hart
C A
CA
Diggle
P J
PJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015373:Bacterial Typing Techniques; D002169:Campylobacter Infections / Q000453:epidemiology* / Q000382:microbiology; D016123:Campylobacter jejuni / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004739:England / Q000453:epidemiology; D004751:Enteritis / Q000453:epidemiology* / Q000382:microbiology; D005260:Female; D005517:Foodborne Diseases / Q000453:epidemiology / Q000382:microbiology; D005838:Genotype; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D012621:Seasons; D017422:Sequence Analysis, DNA; D013997:Time Factors; D055815:Young Adult
D004269:DNA, Bacterial