title: [Genetic factors in the development of language].
abstract: OBJECTIVE
  To review selectively the status of the genetic research in the field of speech and language disorders.
  
  
  METHODS
  Major contributions to the field are selected, presented, and discussed. Twin and family studies have demonstrated that most cognitive traits including language are moderately to highly heritable. Rare mutations affecting the FOXP2 transcription factor cause a monogenic speech and language disorder. The results of association studies of FOXP2 with several language disorders are controversial, probably due to the problem of phenotype definition.
  
  
  CONCLUSIONS
  Common forms of disorders of speech and language are mostly likely associated with variability in the function of multiple genes. Longitudinal studies looking at gene environmental interaction might be important in order to understand the mechanism of language development.
authors.affiliation: Universidad de Valencia, España. julio.sanjuan@uv.es
authors.forename: J
authors.initials: J
authors.lastname: Sanjuán
authors.forename: A
authors.initials: A
authors.lastname: Tolosa
authors.forename: J
authors.initials: J
authors.lastname: Colomer-Revuelta
authors.forename: J
authors.initials: J
authors.lastname: Ivorra-Martínez
authors.forename: B
authors.initials: B
authors.lastname: Llacer
authors.forename: M
authors.initials: M
authors.lastname: Jover
mesh_terms: D051858:Forkhead Transcription Factors / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D007802:Language; D007804:Language Development; D007805:Language Development Disorders / Q000235:genetics*; D007806:Language Disorders / Q000235:genetics*; D009154:Mutation; D010641:Phenotype; D018433:Twin Studies as Topic
chemical_list: C465448:FOXP2 protein, human; D051858:Forkhead Transcription Factors