[Genoprotective effect of sodium humate in conditions of induced oxidative stress].
It was shown that sodium humate in a range of concentration of 50-1000 mg/l reduces a level of clastogenic effects induced with dioxidin (20 mg/l), a prooxidant mutagene. The greatest effect was observed at concentration of 300 mg/l. Direct doze-effect dependence under the influence of sodium humate was not revealed. Possible antioxydative and desmutagenic mechanisms of sodium humate protective action are discussed.
Shkarupa
V M
VM
Baryliak
I R
IR
Neumerzhyts'ka
L V
LV
Humeniuk
I D
ID
D016587:Antimutagenic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006812:Humic Substances; D018519:Meristem / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D009153:Mutagens / Q000633:toxicity; D019697:Onions / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development; D018384:Oxidative Stress / Q000187:drug effects* / Q000235:genetics; D011810:Quinoxalines / Q000633:toxicity
D016587:Antimutagenic Agents; D006812:Humic Substances; D009153:Mutagens; D011810:Quinoxalines; C001077:dioxidine