Multicentric Castleman disease: report of rare disease in Kuwait.
We report a rare case of multicentric Castleman disease diagnosed in Kuwait. A 56-year-old man presented with fever of unknown origin and generalized lymphadenopathy. Laboratory investigations revealed mild anemia and polyclonal gammopathy. Bone marrow biopsy demonstrated 15% increase in plasma cells. Viral screenings including HIV were negative. Lymph node biopsy showed follicular hyperplasia with inter-follicular plasma cells infiltrate with a typical morphology of plasma cell variant of Castleman disease. The patient was treated with methyl-prednisone pulse therapy and showed good response.


CONCLUSIONS
Multicentric Castleman is a rare disease and clinicians and pathologists should be aware of it and should be considered in the differential diagnosis of fever of unknown origin and generalized lymphadenopathy.
Mohammad
B A
BA
Department of Medicine, Al-Farwaniya Hospital, Kuwait.
Al-Brahim
N
N
Kunjhibava
S
S
Ahmad
M
M
Ahmad
M
M
D005871:Castleman Disease / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged