title: Mitomycin C-associated radiofrequency microelectrocautery used in myringotomy in an animal model.
abstract: This study aimed at describing an alternative surgical technique to the insertion of a ventilation tube in the tympanic membrane: myringotomy by radiofrequency alone and associated with mitomycin C.
  
  
  OBJECTIVE
  to show a surgical approach that can be simple to execute, not subject to complications arising from the ventilation tube.
  
  
  METHODS
  we compared myringotomy by microknife and by radiofrequency microcautery (0.3 mm and 0.7 mm tips) alone and associated with mitomycin C, considering the time of tympanic closure in Wistar rats. Experimental study.
  
  
  RESULTS
  there was a statistically significant difference between radiofrequency myringotomy and knife myringotomy. As we analyze the radiofrequency approach with the 0.7 mm tip associated with mitomycin C (Wilcoxon test), the p value found was lower than 0.001, showing a statistical significance. The maximum tympanic membrane closure time was 44 days and the median found was 14 days.
  
  
  CONCLUSIONS
  the radiofrequency myringotomy (with the larger diameter tip) associated with mitomycin C enhances the tympanic membrane healing time.
authors.affiliation: Medical School, Federal University of Rio Grande do Sul.
authors.forename: Vanessa Chisté Guimarães
authors.initials: VC
authors.lastname: Faccini
authors.forename: Luiz
authors.initials: L
authors.lastname: Lavinsky
mesh_terms: D000477:Alkylating Agents / Q000008:administration & dosage*; D000818:Animals; D017115:Catheter Ablation / Q000379:methods*; D008876:Middle Ear Ventilation / Q000379:methods*; D016685:Mitomycin / Q000008:administration & dosage*; D023421:Models, Animal; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014432:Tympanic Membrane / Q000601:surgery*; D014945:Wound Healing
chemical_list: D000477:Alkylating Agents; D016685:Mitomycin