Substitution of corticosteroid with everolimus after lung transplantation: a pediatric case report.
We report the case of a 12 year-old lung transplant recipient, in whom compressive epidural lipomatosis secondary to corticosteroid prompted us to replace prednisone with everolimus. Discontinuing corticosteroid treatment after lung transplantation is associated with a risk of graft rejection despite concomitant immunosuppressive therapy with tacrolimus and mycophenolate mofetil. During a follow-up of 18 months with everolimus instead of prednisone, we did not observe graft rejection. In parallel, all symptoms related to epidural compression disappeared within a month.
Caruba
Thibaut
T
Pharmacy Department, Hopital Européen Georges Pompidou, Assistance Publique Hôpitaux de Paris, Paris, France. thibaut.caruba@egp.aphp.fr
Brunie
Vanida
V
Bousseau
Véronique
V
Guillemain
Romain
R
Prognon
Patrice
P
Bégué
Dominique
D
Sabatier
Brigitte
B
D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D002648:Child; D004824:Epidural Space / Q000473:pathology; D000068338:Everolimus; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D008068:Lipomatosis / Q000139:chemically induced / Q000175:diagnosis; D016040:Lung Transplantation; D020123:Sirolimus / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000305:Adrenal Cortex Hormones; D000068338:Everolimus; D020123:Sirolimus