Thrombocytosis secondary to chronic lead poisoning.
We report a case of total hyperpigmentation of the skin, severe itching, muscle weakness and thrombocytosis. Laboratory investigation showed white blood cell (WBC) 8.2 x 10(6)/L, Hb 125 g/L, platelets 1221 x 10(6)/L and urinary lead after DMSA mobilization test 2684 mcg/g creatinine (normal <5). Chelation therapy with DMSA resulted in complete recovery of the hyperpigmentation, itching and thrombocytosis. Lead poisoning should be considered in the differential diagnosis of obscured thrombocytosis.
Al Momen
Abdulkareem
A
Division of Hematology-Oncology, Department of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia. almomen@ksu.edu.sa
D002614:Chelating Agents / Q000627:therapeutic use; D015913:Chelation Therapy; D002908:Chronic Disease; D004396:Coloring Agents / Q000009:adverse effects; D006801:Humans; D007855:Lead Poisoning / Q000150:complications* / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008875:Middle Aged; D004113:Succimer / Q000627:therapeutic use; D013922:Thrombocytosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
D002614:Chelating Agents; D004396:Coloring Agents; D004113:Succimer