title: Gneyulins A and B, stilbene trimers, and noidesols A and B, dihydroflavonol-C-glucosides, from the bark of Gnetum gnemonoides.
abstract: Gneyulins A (1) and B (2), two new stilbene trimers consisting of oxyresveratrol constituent units, and noidesols A (3) and B (4), two new dihydroflavonol-C-glucosides, were isolated from the bark of Gnetum gnemonoides. The structures and configurations of 1-4 were elucidated on the basis of 2D NMR correlations and X-ray analysis. Gneyulins A (1) and B (2) showed inhibition of Na(+)-glucose transporters (SGLT-1 and SGLT-2).
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Ebara 2-4-41 Shinagawa-ku, Tokyo 142-8501, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shimokawa
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Akao
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hirasawa
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: Seizo
authors.initials: S
authors.lastname: Sato
authors.forename: Chihiro
authors.initials: C
authors.lastname: Aoyama
authors.forename: Jiro
authors.initials: J
authors.lastname: Takeo
authors.forename: Motoo
authors.initials: M
authors.lastname: Shiro
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D018360:Crystallography, X-Ray; D044948:Flavonols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D035684:Gnetum / Q000737:chemistry*; D008296:Malaysia; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D051269:Sodium-Glucose Transporter 1 / Q000037:antagonists & inhibitors; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D044948:Flavonols; D005960:Glucosides; D051269:Sodium-Glucose Transporter 1; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D013267:Stilbenes; C549731:gneyulin A; C549732:gneyulin B; C549733:noidesol A; C549734:noidesol B