Genetics of early-onset obsessive-compulsive disorder.
Obsessive-compulsive disorder (OCD) is characterized by recurrent, intrusive and disturbing thoughts as well as by repetitive stereotypic behaviors. Epidemiological data are similar in children and adults, i.e., between 1 and 3% of the general population suffer from OCD. Children with OCD are often seriously impaired in their development. OCD, especially of early onset, has been shown to be familial. Several candidate genes of predominantly neurotransmitter systems have been analyzed and a total of three genome-wide linkage scans have been performed until now. Analyses of candidate genes in linkage regions have not provided evidence for their involvement in OCD, with the exception of the glutamate transporter gene SLC1A1 on 9p24. Genome-wide association analyses are in progress and the results will promote further independent replication studies. The consideration of subtypes regarding age of onset, symptom dimensions and/or comorbid disorders is needed.
Walitza
Susanne
S
Department of Child and Adolescent Psychiatry, University of Zurich, Zurich, Switzerland. susanne.walitza@kjpdzh.ch
Wendland
Jens R
JR
Gruenblatt
Edna
E
Warnke
Andreas
A
Sontag
Thomas A
TA
Tucha
Oliver
O
Lange
Klaus W
KW
D000293:Adolescent; D002648:Child; D002874:Chromosome Mapping; D004200:Diseases in Twins / Q000175:diagnosis / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study; D006801:Humans; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000235:genetics*; D010641:Phenotype
D005819:Genetic Markers