Protective effect of Labisia pumila on stress-induced behavioral, biochemical, and immunological alterations.
The aim of the present study was to investigate the antistress potential of LABISIA PUMILA aqueous extract (LPPM/A003) using a battery of tests widely employed in different stressful situations. Pretreatment of experimental animals with LPPM/A003 caused an increase in the swimming endurance and hypoxia time and also showed the recovery of physical stress-induced depletion of neuromuscular coordination and scopolamine induced memory deficit. LPPM/A003 at graded doses reversed the chronic restraint stress (RST), induced depletion of CD4 (+) and CD8 (+) T lymphocytes, NK cell population, and corresponding cytokines expression besides downregulating the stress-induced increase in plasma corticosterone, a major stress hormone. In addition, LPPM/A003 reversed the chronic stress-induced increase in adrenal gland weight, serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), and hepatic lipid peroxidation (LP) levels and augmented the RST induced decrease in hepatic glutathione (GSH), thymus and spleen weight. Thus, we conclude that LPPM/A003 has the ability to reverse the alterations produced by various stressful stimuli and therefore restores homeostasis.
Kour
Kiranjeet
K
Department of Pharmacology, Indian Institute of Integrative Medicine, Jammu Tawi, India.
Sharma
Neelam
N
Chandan
Bal Krishan
BK
Koul
Surrinder
S
Sangwan
Payare Lal
PL
Bani
Sarang
S
D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D015687:Cell Hypoxia / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010807:Physical Endurance / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D029623:Primulaceae / Q000737:chemistry*; D020011:Protective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000187:drug effects; D013312:Stress, Physiological; D013550:Swimming; D013950:Thymus Gland / Q000187:drug effects
D010936:Plant Extracts; D020011:Protective Agents; D003345:Corticosterone