The NLRP3 inflammasome, a target for therapy in diverse disease states.
A role for NLRP3 inflammasome in recurrent and chronic inflammation was initially described in a group of rare autoinflammatory conditions, termed cryopyrin-associated periodic syndrome. Subsequently, inflammasomes have been implicated in the pathology of many common diseases, including cancer, gout and diabetes. Despite diverse pathologies, the central role of the inflammasome in innate defences and tumour elimination suggests common therapeutic approaches to reduce inflammation where appropriate.
Cook
Graham P
GP
Section of Oncology and Clinical Research, Leeds Institute of Molecular Medicine, Leeds, UK.
Savic
Sinisa
S
Wittmann
Miriam
M
McDermott
Michael F
MF
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology*; D003877:Dermatitis, Contact / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology*; D046912:Multiprotein Complexes / Q000276:immunology*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D009369:Neoplasms / Q000276:immunology
D002352:Carrier Proteins; D046912:Multiprotein Complexes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human