title: Two new phenylpropanoid derivatives and other constituents from Illicium simonsii active against oral microbial organisms.
abstract: Bioassay-guided fractionation of the ethanol extract of the leaves and stems of Illicium simonsii led to the isolation of two new compounds, simonin A (1) and 1-hydroxyl-2- O- β- D-6'-acetyl-glucopyranosyl-4-allylbenzene (2), along with eight known compounds. Their structures were elucidated by spectroscopic analysis. The isolates were tested for anti-oral microbial activity using a microdilution method. Compounds 1 and 3- 6 showed significant activities against oral microbial organisms (Actinomyces viscosus, Streptococcus mutans, Streptococcus sanguis, and Actinomyces naeslundii), with minimum inhibitory concentration (MIC) values ranging from 1.95 to 31.25 µg/mL in vitro.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, PR China.
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Liu
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Jiang
authors.forename: Chang-An
authors.initials: CA
authors.lastname: Geng
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Zou
authors.forename: Yao
authors.initials: Y
authors.lastname: Shi
authors.forename: Yun-Bao
authors.initials: YB
authors.lastname: Ma
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Ji-Jun
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D000498:Allyl Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D005960:Glucosides / Q000302:isolation & purification* / Q000494:pharmacology; D029523:Illicium / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009055:Mouth / Q000382:microbiology*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018515:Plant Leaves; D018547:Plant Stems; D020005:Propanols / Q000302:isolation & purification / Q000494:pharmacology; D014966:Xanthenes / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000498:Allyl Compounds; D000900:Anti-Bacterial Agents; D005960:Glucosides; D010936:Plant Extracts; D020005:Propanols; D014966:Xanthenes; C556513:simonin A; C439395:1-phenylpropanol