title: Wernicke's encephalopathy during total parenteral nutrition in a child with acute lymphoblastic leukemia and acute pancreatitis.
abstract: We herein describe a 16-year-old child with acute lymphoblastic leukemia and acute pancreatitis who developed Wernicke's encephalopathy secondary to prolonged total parenteral nutrition (TPN) that lacked vitamin B1 supplementation. The patient showed a direct and complete response to thiamine therapy. Diagnostic challenges are discussed and recommendations for prophylactic vitamin B1 supplementation in children with leukemia who are placed on TPN are made.
authors.affiliation: Department of Pediatrics, Medical Center, American University of Beirut, Beirut, Lebanon. sm03@aub.edu.lb
authors.forename: S
authors.initials: S
authors.lastname: Muwakkit
authors.forename: C
authors.initials: C
authors.lastname: Al-Aridi
authors.forename: R
authors.initials: R
authors.lastname: Saab
authors.forename: R
authors.initials: R
authors.lastname: Hourani
authors.forename: N
authors.initials: N
authors.lastname: Yazbeck
authors.forename: M
authors.initials: M
authors.lastname: Abboud
mesh_terms: D000293:Adolescent; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000150:complications / Q000628:therapy; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000628:therapy; D013831:Thiamine / Q000627:therapeutic use; D014899:Wernicke Encephalopathy / Q000209:etiology*
chemical_list: D013831:Thiamine