title: Hepatic complications of obesity.
abstract: Obesity is associated with a spectrum of chronic liver disease. Because obesity increases the risk for advanced forms of liver disease (ie, cirrhosis and liver cancer), the obesity epidemic is emerging as a major factor underlying the burden of liver disease in the United States and many other countries. This article reviews mechanisms that mediate the pathogenesis of obesity-related liver disease, summarizes clinical evidence that demonstrates obesity-related liver disease can be life-threatening, and discusses whether or not treatments for obesity or related comorbidities impact liver disease outcomes.
authors.affiliation: Department of Medicine, Division of Gastroenterology, Duke University, Durham, NC 27710, USA. diehl004@mc.duke.edu
authors.forename: Anna Mae
authors.initials: AM
authors.lastname: Diehl
mesh_terms: D050110:Bariatric Surgery; D001707:Biopsy, Needle; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D018450:Disease Progression; D005234:Fatty Liver / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000209:etiology; D008107:Liver Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D008113:Liver Neoplasms / Q000453:epidemiology / Q000209:etiology; D009765:Obesity / Q000150:complications* / Q000453:epidemiology; D009767:Obesity, Morbid / Q000453:epidemiology; D011379:Prognosis; D045162:Thiazolidinediones / Q000627:therapeutic use; D000637:Transaminases / Q000097:blood; D015431:Weight Loss / Q000502:physiology
chemical_list: D045162:Thiazolidinediones; D000637:Transaminases