title: [Surgical treatment and pathological findings of hematological malignancies patients complicated with lung diseases.].
abstract: OBJECTIVE
  To determine the pulmonary pathological changes in hematological malignancy patients with pulmonary complications.
  
  
  METHODS
  17 hematological malignancy patients underwent surgical treatment were evaluated retrospectively. The pathological changes of all the surgical specimens were examined postoperatively by standard hematoxylin and eosin (HE) staining.
  
  
  RESULTS
  Pathological examination confirmed: aspergillus infection in 9 patients, sub-acute inflammation (fibrosis and hematoma formation) in 3, and each in 1 of pulmonary infarction with granulomatous tissue in the periphery; granulomatous inflammation with calcified tubercle; alveolar dilation and hemorrhage, interstitial fibrosis and focal vasculitis; intercostal neurilemmoma; and moderate-differentiated adenocarcinoma accompanied by intrapulmonary metastasis. And several operative complications (1 case of fungal implantation, 3 pleural effusion and adhesions and 2 pulmonary hematoma) were occurred. The coincidence rate of pre- and post-operative diagnosis was 9/14 (64.3%). After surgery, 8 patients were received hematopoietic stem cell transplantation (HSCT, allo-gene or autologous), with 7 succeeded. On effective secondary antifungal prophylaxis, 4 of 5 patients of aspergillosis succeeded in transplantation with free from mycotic relapse, one patient died from fungal relapse.
  
  
  CONCLUSIONS
  Hematological malignancies with persistent and/or resistant pulmonary infection, hemoptysis, or unexplained lung diseases, should be treated in time by surgery operation to effectively eliminate residual disease and obtain a definitive diagnosis, so as to create a prerequisite condition for the following treatments. Moreover, the secondary antifungal prophylaxis can provide active roles for patients scheduled for chemotherapy and/or HSCT.
authors.affiliation: Department of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital of Soochow University and Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, suzhou 215006, China.
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Tang
authors.forename: Hao-Yue
authors.initials: HY
authors.lastname: Huang
authors.forename: Sheng-Hua
authors.initials: SH
authors.lastname: Zhan
authors.forename: Xing-Wei
authors.initials: XW
authors.lastname: Sun
authors.forename: Xiao-Lan
authors.initials: XL
authors.lastname: Shi
authors.forename: Ai-Ning
authors.initials: AN
authors.lastname: Sun
authors.forename: Zhen-Ya
authors.initials: ZY
authors.lastname: Shen
authors.forename: Su-Ya
authors.initials: SY
authors.lastname: Kang
authors.forename: Zheng-Ming
authors.initials: ZM
authors.lastname: Jin
authors.forename: Hui-Ying
authors.initials: HY
authors.lastname: Qiu
authors.forename: Miao
authors.initials: M
authors.lastname: Miao
authors.forename: Zheng-Zheng
authors.initials: ZZ
authors.lastname: Fu
authors.forename: Yue
authors.initials: Y
authors.lastname: Han
authors.forename: Su-Ning
authors.initials: SN
authors.lastname: Chen
authors.forename: Sheng-Li
authors.initials: SL
authors.lastname: Xue
authors.forename: Xiao
authors.initials: X
authors.lastname: Ma
authors.forename: Yue-Jun
authors.initials: YJ
authors.lastname: Liu
authors.forename: Xiao-Hui
authors.initials: XH
authors.lastname: Hu
authors.forename: Hui-Fen
authors.initials: HF
authors.lastname: Zhou
authors.forename: De-Pei
authors.initials: DP
authors.lastname: Wu
mesh_terms: D001228:Aspergillosis / Q000175:diagnosis; D019337:Hematologic Neoplasms; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008171:Lung Diseases; D009364:Neoplasm Recurrence, Local