title: Mycoplasma genitalium symptoms, concordance and treatment in high-risk sexual dyads.
abstract: The objective of this study was to determine the prevalence and concordance of Mycoplasma genitalium (MG) among Mexican American and African American women and their male sexual partners. Secondary objectives were to determine symptoms of MG infection and persistence of MG after antibiotic therapy. Heterosexual couples were tested for MG and interviewed separately regarding symptoms and behavioural/epidemiologic variables at baseline, six and 12 months. The overall prevalence of MG among women and men was 9.5% and 10.6%, respectively. Subjects were five times more likely to be infected with MG if their sexual partner was MG positive. Among men and women, MG prevalence and mean bacterial loads were similar after receiving single-dose azithromycin, doxycycline or no antibiotics. MG was associated with current urethral discharge in men. No clinical symptoms were specifically diagnostic of MG infection in women.
authors.affiliation: Department of Obstetrics and Gynaecology, Eastern Virginia School of Medicine, CONRAD Clinical Research Center, Norfolk, VA 23507, USA. thurmaar@evms.edu
authors.forename: A R
authors.initials: AR
authors.lastname: Thurman
authors.forename: O
authors.initials: O
authors.lastname: Musatovova
authors.forename: S
authors.initials: S
authors.lastname: Perdue
authors.forename: R N
authors.initials: RN
authors.lastname: Shain
authors.forename: J G
authors.initials: JG
authors.lastname: Baseman
authors.forename: J B
authors.initials: JB
authors.lastname: Baseman
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017963:Azithromycin / Q000627:therapeutic use*; D015897:Comorbidity; D003937:Diagnosis, Differential; D004318:Doxycycline / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D017058:Mexican Americans; D008875:Middle Aged; D009175:Mycoplasma Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology* / Q000208:ethnology; D045704:Mycoplasma genitalium / Q000302:isolation & purification*; D015995:Prevalence; D012747:Sexual Partners; D013781:Texas / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin; D004318:Doxycycline