title: Multiple myeloma of the central nervous system: a clinicopathological review.
abstract: Multiple myeloma (MM) is a systemic malignancy of pathologic plasma cells that is treatable with chemotherapeutic agents and irradiation, but rarely curable. The spectrum of neurological complications of MM is diverse; however, involvement of MM in the cerebrospinal fluid and leptomeningeal infiltration is considered rare. There have been many reviews of central nervous system complications in MM but there are none on intracranial and leptomeningeal infiltration of MM. We review this here along with our clinicopathological experience and a summary of our present knowledge of this condition.
authors.affiliation: Department of Haematology, King Khalid National Guard Hospital, Jeddah, Saudi Arabia. ensobhi@hotmail.com
authors.forename: E
authors.initials: E
authors.lastname: Al-Sobhi
authors.forename: A O
authors.initials: AO
authors.lastname: Osoba
authors.forename: A
authors.initials: A
authors.lastname: Karar
authors.forename: A M
authors.initials: AM
authors.lastname: Zuraiki
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001706:Biopsy; D001932:Brain Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D002555:Cerebrospinal Fluid / Q000166:cytology; D003582:Cytogenetics; D003937:Diagnosis, Differential; D006801:Humans; D016130:Immunophenotyping; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D009101:Multiple Myeloma / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D009367:Neoplasm Staging; D015995:Prevalence; D011379:Prognosis; D035583:Rare Diseases; D015996:Survival Rate; D001613:beta 2-Microglobulin / Q000134:cerebrospinal fluid
chemical_list: D001613:beta 2-Microglobulin