title: Structure elucidation of new oleanane-type glycosides from three species of Acanthophyllum.
abstract: From the roots of three species of Acanthophyllum (Caryophyllaceae), two new gypsogenic acid glycosides, 1 and 2, were isolated, 1 from A. sordidum and A. lilacinum, 2 from A. elatius and A. lilacinum, together with three known saponins, glandulosides B and C, and SAPO50. The structures of 1 and 2 were established mainly by 2D NMR techniques as 23-O-beta-D-galactopyranosylgypsogenic acid-28-O-beta-D-glucopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->6)]-beta-D-galactopyranoside (1) and gypsogenic acid-28-O-beta-D-glucopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->6)]-beta-D-galactopyranoside (2). The cytotoxicity of several of these saponins was evaluated against two human colon cancer cell lines (HT-29 and HCT 116).
authors.affiliation: Laboratoire de Pharmacognosie, UMIB, UPRES EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7 bd. Jeanne D' Arc, BP 87900, 21079 Dijon Cedex, France.
authors.forename: Gaoussou
authors.initials: G
authors.lastname: Timité
authors.forename: Anne-Claire
authors.initials: AC
authors.lastname: Mitaine-Offer
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Miyamoto
authors.forename: Mohammad
authors.initials: M
authors.lastname: Ramezani
authors.forename: Abdolhossein
authors.initials: A
authors.lastname: Rustaiyan
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Mirjolet
authors.forename: Olivier
authors.initials: O
authors.lastname: Duchamp
authors.forename: Marie-Aleth
authors.initials: MA
authors.lastname: Lacaille-Dubois
mesh_terms: D002236:Carbohydrate Conformation; D029748:Caryophyllaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D013045:Species Specificity
chemical_list: C413246:oleanane; D009828:Oleanolic Acid