Tuning the pH sensitivities of orthoester based compounds for drug delivery applications by simple chemical modification.
Orthoesters are acid-sensitive moieties that allow substantial structural diversity for biological applications including drug delivery. Here, the pH-sensitivity of a range of novel orthoester based compounds was compared in the range 7.5-4.5 that is characteristic of the increased acidification during endocytosis. We find that simple modifications close to the orthoester had major effects on both the rate and extent of hydrolysis, suggesting this could be exploited for activating drug delivery systems on endocytic pathways.
Bruyère
Hélène
H
Welsh School of Pharmacy, Cardiff University, Redwood Building, Cardiff CF10 3NB, Wales, UK.
Westwell
Andrew D
AD
Jones
Arwyn T
AT
D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism*; D004952:Esters / Q000737:chemistry / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis
D004337:Drug Carriers; D004952:Esters