title: A comprehensive assessment of outcomes in pregnancies conceived by in vitro fertilization/intracytoplasmic sperm injection.
abstract: OBJECTIVE
  To assess the association between in vitro fertilization (IVF) with or without intracytoplasmic sperm injection (ICSI) and adverse birth outcomes.
  
  
  METHODS
  Retrospective cohort study involved IVF/ICSI patients who were treated in the Ottawa Fertility Centre from 1996 to 2005 with a viable pregnancy (>20 weeks of gestation) and mothers who conceived naturally.
  
  
  RESULTS
  Eleven of the 1044 infants conceived with IVF/ICSI (1.1%) and 7 of the 1910 naturally conceived infants (0.4%) had congenital heart defects (P<0.01). Five of the 138 infants (3.6%) born to mothers with a body mass index>30 and conceived by IVF/ICSI had congenital heart defects, compared with none in the 240 infants born to mothers with a body mass index>30 and conceived naturally (P<0.01).
  
  
  CONCLUSIONS
  Infants conceived with use of IVF/ICSI have three times as high a risk of a congenital heart defect as naturally conceived infants.
authors.affiliation: Department of Obstetrics and Gynecology, University of Ottawa Faculty of Medicine, Ottawa, Ontario, Canada. swwen@ohri.ca
authors.forename: Shi Wu
authors.initials: SW
authors.lastname: Wen
authors.forename: Arthur
authors.initials: A
authors.lastname: Leader
authors.forename: Ruth Rennicks
authors.initials: RR
authors.lastname: White
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Léveillé
authors.forename: Valerie
authors.initials: V
authors.lastname: Wilkie
authors.forename: Jia
authors.initials: J
authors.lastname: Zhou
authors.forename: Mark C
authors.initials: MC
authors.lastname: Walker
mesh_terms: D000328:Adult; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro / Q000009:adverse effects*; D006330:Heart Defects, Congenital / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D008499:Medical Records; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D016896:Treatment Outcome