Relationship between insulin resistance and inflamation markers in hemodialysis patients.
OBJECTIVE
The prevalence and risk factors of cardiovascular disease (CVD) are increasing in end stage renal disease (ESRD) patients. In this study, we sought to research the relationship between the insulin resistance, which is one of the risk factors for CVD, and the inflammation markers, especially C-reactive protein, fibrinogen, uric acid, and homocysteine levels in our patients who were recently diagnosed with ESRD and started hemodialysis.


METHODS
64 HOMA-IR-positive and 114 HOMA-IR-negative patients were enrolled in this study. Blood samples were obtained from the patients for fasting plasma glucose, insulin, CRP, fibrinogen, uric acid, total homocysteine, urea, total cholesterol, HDL-cholesterol, LDL-cholesterol, triglyceride, total protein, and albumin analysis after physical examinations and anamnesis were completed.


RESULTS
Fibrinogen and CRP levels of HOMA-IR-positive HD patients were significantly increased compared to non-insulin resistants. Furthermore, there is significant positive relationship between insulin resistance and serum CRP and fibrinogen levels in these HOMA-IR-positive HD patients (r = 0.258, p < 0.001).


CONCLUSIONS
We found out that the fibrinogen and CRP levels are significantly high in HOMA-IR positive HD patients, according to determine the risk ratio for coronary artery disease in HD patients, and think that an assessment of insulin resistance is necessary.
Borazan
Ali
A
Mustafa Kemal University, Department of Nephrology, Hatay, Turkey. borazanali@hotmail.com
Binici
Dogan Nasir
DN
D000418:Albumins / Q000378:metabolism; D000704:Analysis of Variance; D015415:Biomarkers / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006710:Homocysteine / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism* / Q000628:therapy*; D050356:Lipid Metabolism; D008297:Male; D006435:Renal Dialysis; D012307:Risk Factors; D014508:Urea / Q000378:metabolism; D014527:Uric Acid / Q000378:metabolism
D000418:Albumins; D015415:Biomarkers; D001786:Blood Glucose; D006710:Homocysteine; D014527:Uric Acid; D014508:Urea; D005340:Fibrinogen; D002097:C-Reactive Protein