title: Fluorescence diffuse optical tomography for free-space and multifluorophore studies.
abstract: We present two major advances in preclinical fluorescence-enhanced diffuse optical tomography (fDOT) system and assess its performance. It is now possible to perform experiments without adaptation liquid or a glass plate over the animal, and our system is equipped with a filter wheel in order to discriminate two injected fluorophores. Evaluation carried out on characterization phantoms and in vivo on mice demonstrates enriched use of the system for biological studies on small animals.
authors.affiliation: CEA-LETI, Minatec, Grenoble, France. anne.koenig@cea.fr
authors.forename: Anne
authors.initials: A
authors.lastname: Koenig
authors.forename: Lionel
authors.initials: L
authors.lastname: Hervé
authors.forename: Georges
authors.initials: G
authors.lastname: Gonon
authors.forename: Véronique
authors.initials: V
authors.lastname: Josserand
authors.forename: Michel
authors.initials: M
authors.lastname: Berger
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Dinten
authors.forename: Jérome
authors.initials: J
authors.lastname: Boutet
authors.forename: Philippe
authors.initials: P
authors.lastname: Peltié
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Coll
authors.forename: Philippe
authors.initials: P
authors.lastname: Rizo
mesh_terms: D000818:Animals; D005260:Female; D005456:Fluorescent Dyes / Q000737:chemistry*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D007834:Lasers; D008325:Mammary Neoplasms, Experimental / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D041622:Tomography, Optical / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods
chemical_list: D005456:Fluorescent Dyes