Precursor-directed biosynthesis of curcumin analogs in Escherichia coli.
Curcuminoids, natural products in the rhizome of turmeric, show various biological activities, including antioxidant and antitumor activities. For this reason, curcuminoids have been focused on as potential pharmaceuticals. Exogenous supplementation with various carboxylate precursors in genetically engineered Escherichia coli cells carrying an artificially assembled pathway for curcuminoid biosynthesis led to the production of 17 unnatural curcuminoids.
Katsuyama
Yohei
Y
Department of Biotechnology, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Tokyo, Japan.
Hirose
Yutaka
Y
Funa
Nobutaka
N
Ohnishi
Yasuo
Y
Horinouchi
Sueharu
S
D002264:Carboxylic Acids / Q000378:metabolism; D003373:Coumaric Acids / Q000378:metabolism; D003474:Curcumin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism*; D005818:Genetic Engineering; D007218:Industrial Microbiology / Q000379:methods*; D030781:Organisms, Genetically Modified / Q000235:genetics / Q000378:metabolism; D048630:Polyketide Synthases / Q000378:metabolism; D011422:Propionates
D002264:Carboxylic Acids; D003373:Coumaric Acids; D011422:Propionates; D048630:Polyketide Synthases; C495469:p-coumaric acid; D003474:Curcumin