title: Peyer's Patches in the Terminal Ileum in Ulcerative Colitis: Magnifying Endoscopic Findings.
abstract: Peyer's patches (PPs), a major component of the gut-associated lymphoid tissue, serve as important antigen entry sites in mucosal immunity. PPs may play a role in the extension of ulcerative colitis (UC) into the terminal ileum. We sought to clarify the magnified endoscopic findings of the PPs in the terminal ileum of UC patients. Eighteen UC patients underwent magnifying chromoendoscopy before initial treatment to evaluate the follicle-associated epithelium (FAE) on the PPs domes and the surrounding villi. In 8 UC patients, as in healthy controls, the PPs' domes were slightly elevated, covered with the regular FAE lining, and surrounded by dense and bulky villi; however, in 10 UC patients, the PPs' domes were irregular, and the surrounding villi were sparse and atrophic. These abnormal findings within the PPs were associated with minimal mucosal lesions but not with backwash ileitis; both electron microscopy and magnifying endoscopy confirmed that these lesions were reversible following remission with prednisolone-mesalazine therapy. Similar to Crohn's disease patients, UC patients commonly had abnormalities in the FAE on PPs' domes and the surrounding villi on magnifying endoscopy.
authors.affiliation: Second Department of Internal Medicine, Nagasaki University Hospital, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Ishii
authors.forename: Hajime
authors.initials: H
authors.lastname: Isomoto
authors.forename: Saburo
authors.initials: S
authors.lastname: Shikuwa
authors.forename: Tomayoshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Naoki
authors.initials: N
authors.lastname: Inoue
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Yamaguchi
authors.forename: Ken
authors.initials: K
authors.lastname: Ohnita
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nanashima
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ito
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakao
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohno