title: Failures of feedback: rush hour along the highway to obesity.
abstract: From hot dogs to Hashimoto's and inheritance to inactivity, many "entrance ramps" converge onto the "Highway to Obesity", each contributing caloric intake that exceeds expenditure. Initially, the hypothalamus regulates appetite and energy based on leptin feedback, until feedback failure increases appetite, and allows deposition of abdominal fat, metabolic dysregulation, and metabolic syndrome. Without feedback controls, progress toward obesity is unimpeded unless diet, exercise, and/or medications provide an exit ramp.
authors.affiliation: Clinical Laboratory Science Department, HSB Rm 314, One University Place, Springfield, IL 62703, USA. wgade1@uis.edu
authors.forename: Wayne
authors.initials: W
authors.lastname: Gade
authors.forename: Jean
authors.initials: J
authors.lastname: Gade
authors.forename: Melissa
authors.initials: M
authors.lastname: Collins
authors.forename: Jessica
authors.initials: J
authors.lastname: Schmit
authors.forename: Nicole
authors.initials: N
authors.lastname: Schupp
mesh_terms: D000328:Adult; D000818:Animals; D025461:Feedback, Physiological; D020022:Genetic Predisposition to Disease; D006801:Humans; D020738:Leptin / Q000502:physiology; D009765:Obesity / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy
chemical_list: D020738:Leptin