Reaction of Fe3(CO)12 with octreotide--chemical, electrochemical and biological investigations.
In search for peptidic [FeFe] hydrogenase mimics, the cyclic disulfide Sandostatin (octreotide) was allowed to react with Fe(3)(CO)(12). An octreotide-Fe(2)(CO)(6) complex was isolated and characterized spectroscopically as well as by elemental and thermochemical analysis. The complex catalyzes the electrochemical reduction of H(+) to H(2). It is suggested by radioligand binding assays that the complex retains much of the binding affinity for the somatostatin hsst(1-5) receptors of octreotide.
Apfel
Ulf-Peter
UP
Institut für anorganische und analytische Chemie, Friedrich-Schiller Universität, August-Bebel-Strasse 2, 07751, Jena, Germany.
Rudolph
Manfred
M
Apfel
Christina
C
Robl
Christian
C
Langenegger
Daniel
D
Hoyer
Daniel
D
Jaun
Bernhard
B
Ebert
Marc-Olivier
MO
Alpermann
Theodor
T
Seebach
Dieter
D
Weigand
Wolfgang
W
D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry*; D001426:Bacterial Proteins / Q000737:chemistry; D002254:Carbonates / Q000737:chemistry*; D020134:Catalytic Domain; D055664:Electrochemical Techniques; D005290:Ferric Compounds / Q000737:chemistry*; D006801:Humans; D006864:Hydrogenase / Q000737:chemistry; D007506:Iron-Sulfur Proteins / Q000737:chemistry; D015394:Molecular Structure; D015282:Octreotide / Q000737:chemistry*; D013004:Somatostatin / Q000737:chemistry
D018931:Antineoplastic Agents, Hormonal; D001426:Bacterial Proteins; D002254:Carbonates; D005290:Ferric Compounds; D007506:Iron-Sulfur Proteins; D013004:Somatostatin; C118830:iron hydrogenase; D006864:Hydrogenase; D015282:Octreotide