title: Primary cutaneous CD30 positive anaplastic large cell lymphoma in an adolescent.
abstract: We present a case of a 14-year-old boy with a large ulcerated plaque on the scalp for 6 months, who was found to have primary cutaneous CD30-positive, anaplastic kinase-negative, anaplastic large cell lymphoma with post-auricular lymphadenopathy. MRI, bone marrow biopsy, and laboratory data demonstrated no other systemic involvement. He was treated with radiation and low-dose oral methotrexate, with improvement of the lesion and lymphadenopathy. Very few cases of primary cutaneous CD30-positive anaplastic large cell lymphoma in the pediatric population have been reported, and our case represents one of the first pediatric patients with local lymph node involvement.
authors.affiliation: Pediatrics, Baylor College of Medicine, Houston, Texas 77030, USA. reenamoza@yahoo.com
authors.forename: Reena
authors.initials: R
authors.lastname: Vaid
authors.forename: Bernard
authors.initials: B
authors.lastname: Cohen
mesh_terms: D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D001706:Biopsy; D003131:Combined Modality Therapy; D020405:Dermis / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D017730:Ki-1 Antigen / Q000378:metabolism*; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D012535:Scalp / Q000378:metabolism* / Q000473:pathology*; D012720:Severity of Illness Index; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy
chemical_list: D000964:Antimetabolites, Antineoplastic; D017730:Ki-1 Antigen; D008727:Methotrexate