title: Parameterization of the duration of infection stages of serotype O foot-and-mouth disease virus: an analytical review and meta-analysis with application to simulation models.
abstract: Foot-and-mouth disease (FMD) is considered one of the most important infectious diseases of livestock because of the devastating economic consequences that it inflicts in affected regions. The value of critical parameters, such as the duration of the latency or the duration of the infectious periods, which affect the transmission rate of the FMD virus (FMDV), are believed to be influenced by characteristics of the host and the virus. Disease control and surveillance strategies, as well as FMD simulation models, will benefit from improved parameter estimation. The objective of this study was to quantify the distributions of variables associated with the duration of the latency, subclinical, incubation, and infectiousness periods of FMDV transmission. A double independent, systematic review of 19 retrieved publications reporting results from experimental trials, using 295 animals in four reference laboratories, was performed to extract individual values related to FMDV transmission. Probability density functions were fitted to data and a set of regression models were used to identify factors associated with the assessed parameters. Latent, subclinical, incubation, and infectious periods ranged from 3.1 to 4.8, 2 to 2.3, 5.5 to 6.6, and 3.3 to 5.7 days, respectively. Durations were significantly (p < 0.05) associated independently with route of exposure, type of donor, animal species, strains, characteristics of sampling, and clinical signs. These results will contribute to the improvement of disease control and surveillance strategies and stochastic models used to simulate FMD spread and, ultimately, development of cost-effective plans to prevent and control the potential spread of the disease in FMD-free regions of the world.
authors.affiliation: Center for Animal Disease Modeling and Surveillance (CADMS), School of Veterinary Medicine, University of California, Davis, CA 95616, USA. formardones@ucdavis.edu
authors.forename: Fernando
authors.initials: F
authors.lastname: Mardones
authors.forename: Andrés
authors.initials: A
authors.lastname: Perez
authors.forename: Javier
authors.initials: J
authors.lastname: Sanchez
authors.forename: Mohammad
authors.initials: M
authors.lastname: Alkhamis
authors.forename: Tim
authors.initials: T
authors.lastname: Carpenter
mesh_terms: D000818:Animals; D003198:Computer Simulation; D005536:Foot-and-Mouth Disease / Q000821:virology*; D029544:Foot-and-Mouth Disease Virus / Q000145:classification*; D008954:Models, Biological; D012703:Serotyping