title: Changes in purines concentration in the cerebrospinal fluid of patients experiencing pain: a case-control study.
abstract: This study analyzes the relationship between extracellular purines and pain perception in humans. Cerebrospinal fluid (CSF) levels of purines and their metabolites were compared between patients displaying acute and/or chronic pain syndromes and control subjects. The CSF levels of IMP, inosine, guanosine and uric acid were significantly increased in the chronic pain group and correlated with pain severity (P<0.05). Patients displaying both chronic and acute pain presented similar changes in the CSF purines concentration (P<0.05). However, in the acute pain group, only CSF inosine and uric acid levels were significantly increased (P<0.05). These findings suggest that purines, in special inosine, guanosine and uric acid, are associated with the spinal mechanisms underlying nociception.
authors.affiliation: Department of Biochemistry, ICBS, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
authors.forename: André P
authors.initials: AP
authors.lastname: Schmidt
authors.forename: Ana Elisa
authors.initials: AE
authors.lastname: Böhmer
authors.forename: Félix A
authors.initials: FA
authors.lastname: Soares
authors.forename: Irimar P
authors.initials: IP
authors.lastname: Posso
authors.forename: Sheila B
authors.initials: SB
authors.lastname: Machado
authors.forename: Florentino F
authors.initials: FF
authors.lastname: Mendes
authors.forename: Luis Valmor C
authors.initials: LV
authors.lastname: Portela
authors.forename: Diogo O
authors.initials: DO
authors.lastname: Souza
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001938:Brazil; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000134:cerebrospinal fluid* / Q000523:psychology*; D010147:Pain Measurement / Q000379:methods; D017288:Pain Threshold / Q000502:physiology*; D011446:Prospective Studies; D011687:Purines / Q000134:cerebrospinal fluid*; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D011687:Purines; C030985:purine