title: [Systemic mycosis: factors associated with death among patients infected with the human immunodeficiency virus, Cuiabá, State of Mato Grosso, Brazil, 2005-2008].
abstract: Between 2005 and 2008, the prevalence of systemic mycosis among 1,300 HIV/AIDS patients in Cuiabá, Mato Grosso, was 4.6%. The fungus species isolated were Cryptococcus neoformans in 50%, Cryptococcus gattii in 1.6%, Cryptococcus spp in 6.6%, Histoplasma capsulatum in 38.3% and Paracoccidioides brasiliensis in 3.3%. Death was recorded in the cases of 32 patients (53.3%), and cryptococcosis was the main cause. The CD4+ T lymphocyte count was low and similar among patients who survived or died due to systemic mycosis. The factors independently associated with the deaths of these patients were alcoholism (OR: 8.2; 95% CI: 1.4-62.1; p = 0005) and the mean level of lactate dehydrogenase [758 (182) U/l vs. 416 (268) U/l; p < 0001]. The findings showed that systemic mycosis was highly lethal among the patients with HIV/AIDS in Cuiabá and suggested that clinical-laboratory characteristics such as alcoholism and early elevation of lactate dehydrogenase may be factors relating to worse prognosis under these conditions.
authors.affiliation: Hospital Universitário Júlio Müller, Universidade Federal do Mato Grosso, Cuiabá, MT.
authors.forename: Luciano Correa
authors.initials: LC
authors.lastname: Ribeiro
authors.forename: Rosane Christine
authors.initials: RC
authors.lastname: Hahn
authors.forename: Olivia Cometi
authors.initials: OC
authors.lastname: Favalessa
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tadano
authors.forename: Cor Jesus Fernandes
authors.initials: CJ
authors.lastname: Fontes
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology / Q000401:mortality*; D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D018791:CD4 Lymphocyte Count; D002648:Child; D003430:Cross-Sectional Studies; D003453:Cryptococcosis / Q000401:mortality*; D005260:Female; D006660:Histoplasmosis / Q000401:mortality*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010229:Paracoccidioidomycosis / Q000401:mortality*; D012307:Risk Factors; D019562:Viral Load; D055815:Young Adult