Design and synthesis of 3'-fluoropenciclovir analogues as antiviral agents.
Based on fluorine switch approach, a series of 3'-fluoropenciclovir analogues with different purine and pyrimidine bases were designed and synthesized. Direct reduction of beta-fluoroester to the corresponding 3-fluoroalcohol provided an easy and new entry pathway towards the synthesis of 3'-fluoropenciclovir analogues. The synthesized 3'-fluoropenciclovir analogues were evaluated for their antiviral activities against the poliovirus, HSV-1, HSV-2 and HIV.
Choi
Myung-Hee
MH
College of Pharmacy, Sookmyung Women's University, Seoul 140-742, Korea.
Lee
Chong-Kyo
CK
Kim
Hee-Doo
HD
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D015497:HIV-1 / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D018258:Herpesvirus 2, Human / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D017955:Poliovirus / Q000187:drug effects
D000998:Antiviral Agents; D000212:Acyclovir