title: The management of thyroid carcinoma invading the larynx or trachea.
abstract: OBJECTIVE
  To describe the controversies in the management of thyroid carcinoma invading the airway.
  
  
  METHODS
  Contemporary review of literature; level of evidence: 5.
  
  
  RESULTS
  Invasion of the larynx or trachea by thyroid carcinoma is uncommon and often identified at the time of operation, when the surgeon must decide the extent of resection. Invasion of the airway is associated with loss of tumor differentiation and a reduction in long-term survival compared to tumors limited to the thyroid gland. Whether or not the invaded airway should be resected remains controversial. Tangential shave excision of tumor is commonly performed, despite a marked risk of local recurrence. Circumferential sleeve resection of the larynx and trachea is safe and lowers the risk of local recurrence. In recurrent disease, laryngotracheal resection provides effective palliation of airway obstruction and hemoptysis.
  
  
  CONCLUSIONS
  Long-term (>10-20 years) prospective studies are required to compare the outcome after shave excision with segmental airway resection for thyroid carcinoma. Based on the current literature and on our experience, we advocate circumferential tracheal resection in the setting of airway involvement.
authors.affiliation: Division of Thoracic Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
authors.forename: Jimmie
authors.initials: J
authors.lastname: Honings
authors.forename: Antonia E
authors.initials: AE
authors.lastname: Stephen
authors.forename: Henri A
authors.initials: HA
authors.lastname: Marres
authors.forename: Henning A
authors.initials: HA
authors.lastname: Gaissert
mesh_terms: D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007822:Laryngeal Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D007825:Laryngectomy / Q000379:methods*; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D015996:Survival Rate / Q000639:trends; D013964:Thyroid Neoplasms / Q000401:mortality / Q000601:surgery*; D013965:Thyroidectomy / Q000379:methods*; D013997:Time Factors; D014132:Trachea / Q000601:surgery*; D014134:Tracheal Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome