title: Optimization of prednisolone acetate-loaded chitosan microspheres using a 2(3) factorial design for preventing restenosis.
abstract: Prednisolone acetate (PA)-loaded microspheres were prepared by the spray-drying technique using different polymer (1% and 2%) and drug concentrations (10% and 20%). To obtain the optimum formulation, a three-factor two-level (2(3)) design was employed. The independent variables were polymer molecular weight, polymer concentration, and theoretical drug loading. Responses were the particle size, percentage of encapsulation efficiency, and the t(50%) release. The best formulation was prepared with 20% of PA and 1% of chitosan with medium molecular weight showing relative good yield of production (48.0 + or - 6.7%) and encapsulation efficiency (45.7 + or - 0.3%), and released the drug at a constant rate in 11 days.
authors.affiliation: Hacettepe University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06100 Sihhiye-Ankara, Turkey. scalis@hacettepe.edu.tr
authors.forename: Can
authors.initials: C
authors.lastname: Sarisözen
authors.forename: Betül
authors.initials: B
authors.lastname: Arica
authors.forename: Mehmet N
authors.initials: MN
authors.lastname: Orman
authors.forename: A Atilla
authors.initials: AA
authors.lastname: Hincal
authors.forename: Sema
authors.initials: S
authors.lastname: Caliş
mesh_terms: D001158:Arteries / Q000502:physiology; D002152:Calorimetry, Differential Scanning; D048271:Chitosan / Q000737:chemistry*; D003890:Desiccation; D004339:Drug Compounding; D006083:Graft Occlusion, Vascular / Q000517:prevention & control*; D006965:Hyperplasia / Q000517:prevention & control; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011355:Prodrugs / Q000008:administration & dosage* / Q000627:therapeutic use*; D012995:Solubility; D015607:Stents
chemical_list: D011355:Prodrugs; C009935:prednisolone acetate; D048271:Chitosan; D011239:Prednisolone