title: Metabolic syndrome and endometrial carcinoma.
abstract: The authors examined the association between the metabolic syndrome and risk of incident endometrial and fatal uterine corpus cancer within a large prospective cohort study. Approximately 290,000 women from Austria, Norway, and Sweden were enrolled during 1974-2005, with measurements of height, weight, systolic and diastolic blood pressure, and circulating levels of glucose, total cholesterol, and triglycerides. Relative risks were estimated using Cox proportional hazards regression. The metabolic syndrome was assessed as a composite z score, as the standardized sum of z scores for body mass index, blood pressure, glucose, cholesterol, and triglycerides. A total of 917 endometrial carcinomas and 129 fatal cancers were identified. Increased risks of incident endometrial carcinoma and fatal uterine corpus cancer were seen for the metabolic syndrome factors combined, as well as for individual factors (except for cholesterol). The relative risk of endometrial carcinoma for the metabolic syndrome was 1.37 (95% confidence interval: 1.28, 1.46) per 1-unit increment of z score. The positive associations between metabolic syndrome factors (both individually and combined) and endometrial carcinoma were confined to the heaviest women. The association between the metabolic syndrome and endometrial carcinoma risk seems to go beyond the risk conferred by obesity alone, particularly in women with a high body mass index.
authors.affiliation: Department of Public Health and Primary Health Care, University of Bergen, N-5018 Bergen, Norway. tone.bjorge@isf.uib.no
authors.forename: Tone
authors.initials: T
authors.lastname: Bjørge
authors.forename: Tanja
authors.initials: T
authors.lastname: Stocks
authors.forename: Annekatrin
authors.initials: A
authors.lastname: Lukanova
authors.forename: Steinar
authors.initials: S
authors.lastname: Tretli
authors.forename: Randi
authors.initials: R
authors.lastname: Selmer
authors.forename: Jonas
authors.initials: J
authors.lastname: Manjer
authors.forename: Kilian
authors.initials: K
authors.lastname: Rapp
authors.forename: Hanno
authors.initials: H
authors.lastname: Ulmer
authors.forename: Martin
authors.initials: M
authors.lastname: Almquist
authors.forename: Hans
authors.initials: H
authors.lastname: Concin
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Håkan
authors.initials: H
authors.lastname: Jonsson
authors.forename: Pär
authors.initials: P
authors.lastname: Stattin
authors.forename: Anders
authors.initials: A
authors.lastname: Engeland
mesh_terms: D000328:Adult; D000368:Aged; D001317:Austria / Q000453:epidemiology; D015992:Body Mass Index; D002423:Cause of Death; D015331:Cohort Studies; D016889:Endometrial Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D024821:Metabolic Syndrome / Q000150:complications* / Q000175:diagnosis; D008875:Middle Aged; D009664:Norway / Q000453:epidemiology; D011159:Population Surveillance; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012042:Registries; D012044:Regression Analysis; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology