Saline nebulization before gastric lavage in the diagnosis of pulmonary tuberculosis in children and adolescents.
The main objective is to assess whether nebulization before gastric lavage (GL) improves its sensitivity for the diagnosis of childhood tuberculosis (TB). Children and adolescents suspected of pulmonary TB were randomly assigned (1 : 2) to nebulization with hypertonic saline 30 min before GL (Neb group; n = 36) or GL without prior nebulization (controls; n = 68). The proportion of positive GL smears was greater in Neb group than in the control group; however, no statistical significance was observed (36.3% vs. 22.2%; p = 0.4). Inhalation of nebulized hypertonic saline before GL did not improve TB diagnosis in this study. Nevertheless, the validation of our data will require large longitudinal studies.
Maciel
Ethel Leonor
EL
Peres
Renata Lyrio
RL
do Prado
Thiago Nascimento
TN
Macedo
Cristina Ribeiro
CR
Palaci
Moisés
M
Vinhas
Solange Alves
SA
Dietze
Reynaldo
R
Johnson
John L
JL
Struchiner
Claúdio Jose
CJ
D000293:Adolescent; D002648:Child; D005260:Female; D005751:Gastric Lavage; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D009330:Nebulizers and Vaporizers; D012462:Saline Solution, Hypertonic; D012680:Sensitivity and Specificity; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000382:microbiology
D012462:Saline Solution, Hypertonic