title: Enantioselective organocatalytic mannich reactions with autocatalysts and their mimics.
abstract: The Mannich reactions previously extensively investigated with organocatalysis of l-proline and other related small molecules were reinvestigated with detailed stereochemical analysis of their autocatalysis pathways, through employment of both the products themselves and their close structural mimics as the catalysts. These organo-autocatalytic processes function as meaningful molecular models toward understanding the origin and maintenance of homochirality under biologically relevant conditions.
authors.affiliation: School of Chemical Biology and Biotechnology, Shenzhen Graduate School of Peking University, Shenzhen University Town, Shenzhen 518055, China.
authors.forename: Xinbo
authors.initials: X
authors.lastname: Wang
authors.forename: Yongbo
authors.initials: Y
authors.lastname: Zhang
authors.forename: Haibo
authors.initials: H
authors.lastname: Tan
authors.forename: Yanchao
authors.initials: Y
authors.lastname: Wang
authors.forename: Peng
authors.initials: P
authors.lastname: Han
authors.forename: David Zhigang
authors.initials: DZ
authors.lastname: Wang
mesh_terms: D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008958:Models, Molecular; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011392:Proline / Q000737:chemistry*; D013237:Stereoisomerism; D015032:Zinc / Q000737:chemistry*
chemical_list: D009942:Organometallic Compounds; D011392:Proline; D015032:Zinc