Antiulcerogenic activity of ethanolic leaf extract of Lasianthera africana.
The effect of ethanolic leaf extract of Lasianthera africana on experimentally induced ulcer was studied in rats. The extract (1000 - 3000mg/kg) inhibited ethanol-induced, indomethacin - induced and reserpine -induced ulcer models in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.01). The effect of the extract was comparable to that of the standard drugs used. Thus, Lasianthera africana extract demonstrated a good antiulcer activity which supports the antiulcer effect of this plant in traditional medicine.
Okokon
Jude E
JE
Department of Pharmacology and Toxicology, University of Uyo, Uyo, Nigeria. judeefiom@yahoo.com
Antia
Bassey S
BS
Umoh
Emem E
EE
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007213:Indomethacin; D019684:Magnoliopsida; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves; D051381:Rats; D012110:Reserpine; D013270:Stomach / Q000187:drug effects* / Q000473:pathology; D013276:Stomach Ulcer / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D012110:Reserpine; D007213:Indomethacin