title: [Effects of danhong injection on experimental atherosclerosis rabbit model and its mechanism].
abstract: OBJECTIVE
  To observe the effects of Danhong injection on experimental atherosclerosis rabbits and explore its possible mechanism.
  
  
  METHODS
  Forty New-Zealand male rabbits were randomly divided into four groups: normal control group, high-cholesterol group, danhong injection group and aspirin group, all rabbits were administered for fourteen weeks. The plaque area of aorta in each group was determined by image analysis. The blood lipid level was tested by ELISA method, malonaldehyde (MDA) in aorta wall was analyzed with thiobarbituric acid method, the iNOS and COX-2 in aorta wall was tested with RT-PCR method.
  
  
  RESULTS
  There were significant difference between danhong injection group and other groups (P < 0.5), danhong injection and Aspirin decreased the TG, TC and LDL-C level in plasma of rabbit model and decreased the expression of inflammatory cytokines and the oxidative stress level in aorta wall.
  
  
  CONCLUSIONS
  Danhong injection can inhibit the formation of experimental atherosclerosis in rabbits, which may be related to decreasing blood lipid, plaque inflammation and oxidative stress level.
authors.affiliation: Guangdong Provincial People's Hospital, Guangzhou 510080, China. tien404@hotmail.com
authors.forename: Ting-ting
authors.initials: TT
authors.lastname: Fu
authors.forename: Chang-jun
authors.initials: CJ
authors.lastname: Wang
authors.forename: Cun-yun
authors.initials: CY
authors.lastname: Min
authors.forename: Xu-hui
authors.initials: XH
authors.lastname: Huang
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use; D050197:Atherosclerosis / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D031187:Carthamus tinctorius / Q000737:chemistry; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D007267:Injections; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D011817:Rabbits; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood
chemical_list: D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D014280:Triglycerides; C540581:danhong; D008315:Malondialdehyde; D002784:Cholesterol; D019001:Nitric Oxide Synthase; D001241:Aspirin