Protective effect of sesamol against myocardial infarction caused by isoproterenol in Wistar rats.
This study was designed to investigate the cardioprotective effect of sesamol on isoproterenol (ISO)-induced myocardial infarction in adult male albino Wistar rats. The heart damage induced by ISO was indicated by elevated levels of the marker enzymes such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase-MB (CK-MB) and the levels of troponin T and I in the plasma. In addition, lipid peroxidative markers such as thiobarbituric acid reactive substances (TBARS), conjugated dienes (CD) and lipid hydroperoxides (LHP) significantly increased in the plasma and heart. Activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR) significantly decreased in the heart and (non-enzymic antioxidants) vitamin C, vitamin E and reduced glutathione (GSH)) levels significantly decreased in the plasma and heart in ISO-rats. Histopathological observations correlated with the biochemical parameters. Administration of sesamol at different doses 50, 100 and 200 mg/kg body weight intraperitoneally for 7 days prevented the above changes and improved towards normality; the 50 mg dose was more effective than the other two doses.
Vennila
Lakshmanan
L
Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalainagar 608 002, Tamilnadu, India.
Pugalendi
Kodukkur Viswanathan
KV
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001205:Ascorbic Acid / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000097:blood; D052117:Benzodioxoles / Q000627:therapeutic use*; D003402:Creatine Kinase / Q000097:blood; D005978:Glutathione / Q000378:metabolism; D007545:Isoproterenol; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced / Q000201:enzymology / Q000473:pathology / Q000517:prevention & control*; D009206:Myocardium / Q000473:pathology; D010636:Phenols / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D019210:Troponin I / Q000378:metabolism; D020107:Troponin T / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism
D000975:Antioxidants; D052117:Benzodioxoles; D008054:Lipid Peroxides; D010636:Phenols; D017392:Thiobarbituric Acid Reactive Substances; D019210:Troponin I; D020107:Troponin T; D014810:Vitamin E; C025583:sesamol; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase; D005978:Glutathione; D007545:Isoproterenol; D001205:Ascorbic Acid