[Myocardial injuries induced by oxidative stress in rat--experimental morphopathological study].
Oxidative stress is a phenomenon significantly involved in several clinical conditions such as ischemic heart disease and myocardial reperfusion.


OBJECTIVE
Creating an animal model of oxidative stress based on three methods: exertional (swimming), habitual (light exposure), and corticotropine injections.


METHODS
40 Wistar adult rats, weighting between 210-315 g, were subjected to either none (control group), swimming, light exposure or corticotropine injections for six weeks, then the animals were sacrificed and a light and electronic microscopic examination of the myocardium and ascending aorta were performed.


RESULTS
Histological features of myocardial reperfusion injury were obtained in all cases and not in the control group.


CONCLUSIONS
All three methods consistently induce myocardial morphological injuries similar to that of the ischemia-reperfusion phenomenon, mainly the exposure to light and corticotropine injections, and mainly in the females.
Balasanian
M
M
Institutul de Boli Cardiovasculare Prof. Dr. George I. M. Georgescu, Facultatea de Medicină, Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi.
Bădescu
Magda
M
Dobrescu
Gioconda
G
D000818:Animals; D004195:Disease Models, Animal; D008854:Microscopy, Electron; D017202:Myocardial Ischemia / Q000378:metabolism / Q000473:pathology; D015428:Myocardial Reperfusion Injury / Q000378:metabolism* / Q000473:pathology*; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar