title: The NLRP3 inflammasome, a target for therapy in diverse disease states.
abstract: A role for NLRP3 inflammasome in recurrent and chronic inflammation was initially described in a group of rare autoinflammatory conditions, termed cryopyrin-associated periodic syndrome. Subsequently, inflammasomes have been implicated in the pathology of many common diseases, including cancer, gout and diabetes. Despite diverse pathologies, the central role of the inflammasome in innate defences and tumour elimination suggests common therapeutic approaches to reduce inflammation where appropriate.
authors.affiliation: Section of Oncology and Clinical Research, Leeds Institute of Molecular Medicine, Leeds, UK.
authors.forename: Graham P
authors.initials: GP
authors.lastname: Cook
authors.forename: Sinisa
authors.initials: S
authors.lastname: Savic
authors.forename: Miriam
authors.initials: M
authors.lastname: Wittmann
authors.forename: Michael F
authors.initials: MF
authors.lastname: McDermott
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology*; D003877:Dermatitis, Contact / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology*; D046912:Multiprotein Complexes / Q000276:immunology*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D009369:Neoplasms / Q000276:immunology
chemical_list: D002352:Carrier Proteins; D046912:Multiprotein Complexes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human