title: Obesity among HIV-infected persons: impact of weight on CD4 cell count.
abstract: To assess the effect of obesity on CD4 cell counts, we estimated the association of time-updated BMI categories with CD4 changes among 1001 documented HIV seroconverters. During the pre-highly active antiretroviral therapy (HAART) era, a higher BMI was associated with less reduction in CD4 cell counts over time. However during the HAART era, obese versus normal weight patients had smaller increases in CD4 cell counts (+69 versus +116 cells, P = 0.01). Lower CD4 cell counts may now be another adverse consequence of obesity.
authors.affiliation: Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
authors.forename: Nancy F
authors.initials: NF
authors.lastname: Crum-Cianflone
authors.forename: Mollie
authors.initials: M
authors.lastname: Roediger
authors.forename: Lynn E
authors.initials: LE
authors.lastname: Eberly
authors.forename: Kurt
authors.initials: K
authors.lastname: Vyas
authors.forename: Mike L
authors.initials: ML
authors.lastname: Landrum
authors.forename: Anuradha
authors.initials: A
authors.lastname: Ganesan
authors.forename: Amy C
authors.initials: AC
authors.lastname: Weintrob
authors.forename: Robert Vincent
authors.initials: RV
authors.lastname: Barthel
authors.forename: Brian K
authors.initials: BK
authors.lastname: Agan
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D001835:Body Weight / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D009765:Obesity / Q000276:immunology*; D019562:Viral Load