title: Changes in oxidative stress and insulin resistance in morbidly obese patients after bariatric surgery.
abstract: BACKGROUND
  The prevalence of morbid obesity has seen an increase in developed countries over recent years. Bariatric surgery is almost the only effective strategy for treating super morbidly obese patients. The objective of the study was to evaluate the effects of bariatric surgery on the evolution of the main variables related to diabetes and obesity, especially insulin resistance, parameters of oxidative stress, and inflammatory markers in the early stage after surgery.
  
  
  METHODS
  The study was undertaken in 17 morbidly obese persons who were scheduled for biliopancreatic diversion of Scopinaro. Measurements were made before surgery and 15, 30, 45, and 90 days after surgery.
  
  
  RESULTS
  We found that significant metabolic changes occurred during the first 90 days after bariatric surgery. The most significant decrease in insulin resistance occurred 15 days after the operation. At this point, the lipid profile and inflammatory and oxidative stress parameters had not improved. One month after surgery, insulin resistance had a parallel evolution to weight and the molecules directly associated with hypertrophic adipose tissue.
  
  
  CONCLUSIONS
  We suggest that there are two mechanisms that contribute to the improvement in insulin resistance after biliopancreatic diversion: on the one hand, a short-term effect related to gastric bypass, and on the other hand, a long-term effect from decreased fat mass and resulting changes in the release of molecules directly associated with hypertrophic adipose tissue.
authors.affiliation: Servicio de Endocrinología y Nutrición, Campus Teatinos s/n, Hospital Clínico Universitario Virgen de la Victoria, 29010 Málaga, Spain.
authors.forename: Mora
authors.initials: M
authors.lastname: Murri
authors.forename: Eduardo
authors.initials: E
authors.lastname: García-Fuentes
authors.forename: José Manuel
authors.initials: JM
authors.lastname: García-Almeida
authors.forename: Lourdes
authors.initials: L
authors.lastname: Garrido-Sánchez
authors.forename: María Dolores
authors.initials: MD
authors.lastname: Mayas
authors.forename: Rosa
authors.initials: R
authors.lastname: Bernal
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Tinahones
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000328:Adult; D015904:Biliopancreatic Diversion; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D008297:Male; D009767:Obesity, Morbid / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D018384:Oxidative Stress; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss / Q000502:physiology*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D008055:Lipids