title: Total synthesis of (+/-)-aspercyclide A and its C19 methyl ether.
abstract: The total syntheses of (+/-)-aspercyclide A (1) and its C19 methyl ether (15a) featuring Heck-Mizoroki macrocyclisation to form the 11-membered (E)-styrenyl biaryl ether lactone core are described.
authors.affiliation: Department of Chemistry, South Kensington campus, Imperial College, London, UK SW7 2AZ.
authors.forename: James L
authors.initials: JL
authors.lastname: Carr
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Offermann
authors.forename: Mary D
authors.initials: MD
authors.lastname: Holdom
authors.forename: Philip
authors.initials: P
authors.lastname: Dusart
authors.forename: Andrew J P
authors.initials: AJ
authors.lastname: White
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Beavil
authors.forename: Robin J
authors.initials: RJ
authors.lastname: Leatherbarrow
authors.forename: Stephen D
authors.initials: SD
authors.lastname: Lindell
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Sutton
authors.forename: Alan C
authors.initials: AC
authors.lastname: Spivey
mesh_terms: D018360:Crystallography, X-Ray; D003500:Cyclization; D007783:Lactones / Q000138:chemical synthesis / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008738:Methyl Ethers / Q000737:chemistry*; D008968:Molecular Conformation
chemical_list: D007783:Lactones; D047028:Macrocyclic Compounds; D008738:Methyl Ethers; C542833:aspercyclide A