Patterned multiplex pathogen DNA detection by Au particle-on-wire SERS sensor.
A Au particle-on-wire system that can be used as a specific, sensitive, and multiplex DNA sensor is developed. A pattern formed by multiple Au nanowire sensors provides positional address and identification for each sensor. By using this system, multiplex sensing of target DNAs was possible in a quantitative manner with a detection limit of 10 pM. Target DNAs from reference bacteria and clinical isolates were successfully identified by this sensor system, enabling diagnostics for infectious diseases.
Kang
Taejoon
T
Department of Chemistry, KAIST, Daejeon, Korea.
Yoo
Seung Min
SM
Yoon
Ilsun
I
Lee
Sang Yup
SY
Kim
Bongsoo
B
D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods*; D004269:DNA, Bacterial / Q000032:analysis*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D053770:Nanowires / Q000737:chemistry*; D010316:Particle Size; D012680:Sensitivity and Specificity; D013499:Surface Properties
D004269:DNA, Bacterial; D006046:Gold