Adaptive T cell immune responses and atherogenesis.
Atherosclerosis is a chronic inflammatory disease of the arterial wall where both innate and adaptive immune responses contribute to disease initiation and progression. Initial studies have focused on the role of T helper-1 (Th1) and Th2 responses in atherosclerosis, and more recently evidence has been published supporting a protective role of regulatory T cells in this disease. A third member of the T helper set, IL-17-producing T cells, now called Th17 cells, was recently described as a distinct lineage that play important role in autoimmune diseases. Here, we review the current knowledge on the role of effector and regulatory T cell responses in atherosclerosis and discuss the contribution of the Th17 to this disease.
Taleb
Soraya
S
Inserm U970, Paris Cardiovascular Research Center, 56, rue Leblanc, 75015 Paris, France.
Tedgui
Alain
A
Mallat
Ziad
Z
D056704:Adaptive Immunity / Q000276:immunology*; D000818:Animals; D050197:Atherosclerosis / Q000276:immunology* / Q000378:metabolism; D055808:Drug Discovery / Q000379:methods; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D018448:Models, Immunological; D016176:T-Lymphocyte Subsets / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism*; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism
D018836:Inflammation Mediators