Biological activity resulting from exposure to aquatic environmental genotoxic pollutants in northern Egypt.
We estimated pollution in Lake Edku and the Mediterranean Sea, El-Maadiya Region, with 3 aromatic amines (1-naphthylamine, 2-naphthylamine and benzidine) in the muscle tissue of fish. There were marked seasonal variations in the aromatic amine levels. We also determined oxidative stress (blood glutathione, and catalase activity) and genotoxic effects (chromosomal aberrations and urinary metabolites) in fishermen from each area. The fishermen suffered from oxidative stress and had high levels of the urinary metabolite sulfanilamide [mean (microg/mg creatinine): Lake Edku 20.7, Mediterranean 14.5, controls 5.3]. Frequencies for total chromosomal aberrations were significantly raised in the peripheral blood lymphocytes of fishermen in both areas [frequency (per 100 metaphases): Mediterranean 67, Lake Edku 45, controls 14].
Saad
A A
AA
Department of Applied Medical Chemistry, Medical Research Institute, Alexandria University, Alexandria, Egypt.
El-Sikaily
A M
AM
Kholeif
S F
SF
Khalil
E S
ES
Mahrous
H S
HS
Al-Zabedi
E M S
EM
Kassem
H A
HA
D015057:1-Naphthylamine / Q000009:adverse effects / Q000032:analysis; D015081:2-Naphthylamine / Q000009:adverse effects / Q000032:analysis; D000328:Adult; D000818:Animals; D001560:Benzidines / Q000009:adverse effects / Q000032:analysis; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D002869:Chromosome Aberrations / Q000706:statistics & numerical data; D004249:DNA Damage / Q000502:physiology; D004534:Egypt / Q000453:epidemiology; D004781:Environmental Exposure / Q000009:adverse effects / Q000032:analysis*; D004784:Environmental Monitoring / Q000379:methods; D062665:Epidemiological Monitoring; D005398:Fisheries; D005399:Fishes / Q000378:metabolism; D005618:Fresh Water / Q000032:analysis* / Q000737:chemistry; D005978:Glutathione / Q000097:blood; D006801:Humans; D008297:Male; D008522:Mediterranean Sea / Q000453:epidemiology; D018384:Oxidative Stress / Q000502:physiology; D012621:Seasons; D014874:Water Pollutants, Chemical / Q000009:adverse effects / Q000032:analysis*
D001560:Benzidines; D014874:Water Pollutants, Chemical; C029876:benzidine; D015057:1-Naphthylamine; D015081:2-Naphthylamine; D002374:Catalase; D005978:Glutathione