Rapid regulation of intestinal divalent metal (cation) transporter 1 (DMT1/DCT1) and ferritin mRNA expression in response to excess iron loading in iron-deficient rats.
We determined the effects of excess iron on the expression of duodenal divalent metal transporter 1 (DMT1) and ferritin (Ft) in iron-deficient rats which had increased iron absorption. DMT1 mRNA was down-regulated and Ft mRNA was up-regulated 2 h after administering the iron. However, more than 2 h was needed for Ft protein synthesis to occur in the duodenal mucosa.
Arita
Anna
A
Department of Health Promotion Sciences, Graduate School of Human Health Sciences, Tokyo Metropolitan University, Tokyo, Japan.
Tadai
Kouki
K
Shinoda
Shoko
S
D000818:Animals; D027682:Cation Transport Proteins / Q000378:metabolism*; D004386:Duodenum / Q000187:drug effects* / Q000378:metabolism; D005293:Ferritins / Q000378:metabolism*; D007408:Intestinal Absorption; D000090463:Iron Deficiencies; D019266:Iron, Dietary / Q000008:administration & dosage*; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000099236:Solute Carrier Family 11, Member 2
D027682:Cation Transport Proteins; D005293:Ferritins; D019266:Iron, Dietary; D012333:RNA, Messenger; D000099236:Solute Carrier Family 11, Member 2