title: Enantioselective total synthesis of otteliones A and B.
abstract: Enantioselective total synthesis of otteliones A and B was accomplished. The key steps are radical cyclization of an alpha-iodoketone to construct the cis-hydrindanone skeleton and Suzuki-Miyaura coupling to incorporate the aromatic group. (+)-Ottelione A was converted to (-)-ottelione B on treatment with NaOH in THF.
authors.affiliation: Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, ROC.
authors.forename: Cheng-Hui
authors.initials: CH
authors.lastname: Chen
authors.forename: Yu-Kai
authors.initials: YK
authors.lastname: Chen
authors.forename: Chin-Kang
authors.initials: CK
authors.lastname: Sha
mesh_terms: D003512:Cyclohexanones / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism
chemical_list: D003512:Cyclohexanones; C468748:ottelione A; C468747:ottelione B