title: Multicentric Castleman disease: report of rare disease in Kuwait.
abstract: We report a rare case of multicentric Castleman disease diagnosed in Kuwait. A 56-year-old man presented with fever of unknown origin and generalized lymphadenopathy. Laboratory investigations revealed mild anemia and polyclonal gammopathy. Bone marrow biopsy demonstrated 15% increase in plasma cells. Viral screenings including HIV were negative. Lymph node biopsy showed follicular hyperplasia with inter-follicular plasma cells infiltrate with a typical morphology of plasma cell variant of Castleman disease. The patient was treated with methyl-prednisone pulse therapy and showed good response.
  
  
  CONCLUSIONS
  Multicentric Castleman is a rare disease and clinicians and pathologists should be aware of it and should be considered in the differential diagnosis of fever of unknown origin and generalized lymphadenopathy.
authors.affiliation: Department of Medicine, Al-Farwaniya Hospital, Kuwait.
authors.forename: B A
authors.initials: BA
authors.lastname: Mohammad
authors.forename: N
authors.initials: N
authors.lastname: Al-Brahim
authors.forename: S
authors.initials: S
authors.lastname: Kunjhibava
authors.forename: M
authors.initials: M
authors.lastname: Ahmad
authors.forename: M
authors.initials: M
authors.lastname: Ahmad
mesh_terms: D005871:Castleman Disease / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged