Principles of cellular-molecular mechanisms underlying neuron functions.
In the present work, it was experimentally shown that a neuron in vitro was capable of responding in a manner similar to habituation, Pavlov's reflex and avoidance of the reinforcements. The locality of plastic property modifications and molecular morphology, as well as the connection between functional activity and cytoskeleton have been revealed. A hypothesis is formulated that the neuron is a molecular system which may exercise the control, forecast, recognition, and classification. The basic principles of the molecular mechanisms of the responses underlying integrative activity, learning and memory at the neuronal level are discussed.
Ratushnyak
Alexander S
AS
Design Technological Institute of Digital Techniques SB RAS, Novosibirsk, 63009, Russia. ratush@mail.ru
Zapara
Tatiana A
TA
D000818:Animals; D002490:Central Nervous System / Q000166:cytology / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology* / Q000648:ultrastructure; D004594:Electrophysiology / Q000379:methods / Q000639:trends; D017952:Ganglia, Invertebrate / Q000166:cytology / Q000502:physiology*; D007858:Learning / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology; D008195:Lymnaea / Q000166:cytology / Q000502:physiology*; D008568:Memory / Q000502:physiology; D023421:Models, Animal; D009446:Neurobiology / Q000379:methods / Q000639:trends; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009482:Neurophysiology / Q000379:methods / Q000639:trends