[Clinical features, laboratory findings and imaging appearances of venous diethylene glycol poisoning in patients with liver disease].
OBJECTIVE
To summarize and report the clinical features, laboratory findings and imaging appearances of venous diethylene glycol poisoning in patients with liver disease.


METHODS
The clinical features of 15 venous diethylene glycol poisoning patients with liver disease were analyzed and summarized, their laboratory findings and imaging appearances were comparative analyzed before and after poisoning.


RESULTS
All poisoned patients presented oliguric acute renal failure with anuria after a mean of 6 days. Carbon dioxide combination power of 13 patients was dropped after a mean of 9 days with trough value at the 10th day, and metabolic acidosis was developed. Gastroenteric symptoms or aggravation of gastroenteric symptoms were displayed in 11 patients after a mean of 9 days. Neurological system impairment was observed in 10 patients after a mean of 14 days. Seven patients had low fever after a mean of 6 days. Causes of death of 14 patients included multiple organ dysfunction syndrome, severe lung infection and massive haemorrhage of digestive tract. Blood creatinine and urea nitrogen were abnormal after a mean of 5 days with peak value at the 11th and 14th days respectively. Serum calcium had no obvious change, and phosphorus was increased distinctly. Liver functions did not change significantly. Poisoned patients had higher white blood cell counts, lower red blood cell counts and hemoglobin value. Of the 7 patients exhibited mild, moderate and severe patchy consolidation shadowing in the lung, 2 manifested mild or severe gaseous distention and dilation of gastroenteric tract.


CONCLUSIONS
Main features of venous diethylene glycol poisoning in patients with liver disease include oliguric acute renal failure, metabolic acidosis, gastroenteric symptoms or aggravation of gastroenteric symptoms, neurological system impairment and low fever, with a mortality of 93.33% of poisoned patients; higher white blood cell counts and anemia; patchy consolidation shadowing in the lung; gaseous distention and dilation of gastroenteric tract, which occures later than mild patchy consolidation shadowing and earlier than moderate patchy consolidation shadowing do in the lung.
Luo
Ming-yue
MY
Department of Radiology, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou 510655, China.
Lin
Bing-liang
BL
Gao
Zhi-liang
ZL
D058186:Acute Kidney Injury / Q000139:chemically induced; D000328:Adult; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000473:pathology; D003952:Diagnostic Imaging; D005026:Ethylene Glycols / Q000032:analysis / Q000506:poisoning*; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis* / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014680:Veins
D005026:Ethylene Glycols; C013484:diethylene glycol