title: Integrated intravascular optical coherence tomography ultrasound imaging system.
abstract: We report on a dual-modality optical coherence tomography (OCT) ultrasound (US) system for intravascular imaging. To the best of our knowledge, we have developed the first integrated OCT-US probe that combines OCT optical components with an US transducer. The OCT optical components mainly consist of a single-mode fiber, a gradient index lens for light-beam focusing, and a right-angled prism for reflecting light into biological tissue. A 40-MHz piezoelectric transducer (PZT-5H) side-viewing US transducer was fabricated to obtain the US image. These components were integrated into a single probe, enabling both OCT and US imaging at the same time. In vitro OCT and ultrasound images of a rabbit aorta were obtained using this dual-modality imaging system. This study demonstrates the feasibility of an OCT-US system for intravascular imaging, which is expected to have a prominent impact on early detection and characterization of atherosclerosis.
authors.forename: Jiechen
authors.initials: J
authors.lastname: Yin
authors.forename: Hao-Chung
authors.initials: HC
authors.lastname: Yang
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Qifa
authors.initials: Q
authors.lastname: Zhou
authors.forename: Changhong
authors.initials: C
authors.lastname: Hu
authors.forename: K Kirk
authors.initials: KK
authors.lastname: Shung
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000818:Animals; D001011:Aorta / Q000033:anatomy & histology; D004867:Equipment Design; D011817:Rabbits; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods*; D018084:Ultrasonography, Interventional / Q000295:instrumentation* / Q000379:methods*