title: The role of continuous positive airway pressure in the treatment of hypertension in patients with obstructive sleep apnea-hypoapnea syndrome: a review of randomized trials.
abstract: Obstructive sleep apnea-hypoapnea syndrome (OSA) is a disorder that results in repetitive occlusion of the airway and hypoxemia during sleep. Epidemiologic studies have associated this disorder with increased cardiovascular morbidity and mortality. Systemic hypertension is prevalent among patients with OSA and has been recognized as a common identifiable cause of hypertension. Nasal continuous positive airway pressure (nCPAP) ventilation is an effective therapy for OSA and it may additionally reduce blood pressure. The use of nCPAP ventilation to treat hypertension in patients with OSA has been studied extensively. However, whether it is effective in treating hypertension in this population remains unclear. This review evaluates the recent literature that investigates the effects of nCPAP ventilation on hypertension in patients with OSA.
authors.affiliation: Department of Internal Medicine, Cardiology Division, University of Rochester Medical Center, Rochester, NY, USA.
authors.forename: Mohan
authors.initials: M
authors.lastname: Rao
authors.forename: Geet
authors.initials: G
authors.lastname: Rajda
authors.forename: Sarada
authors.initials: S
authors.lastname: Uppuluri
authors.forename: G Ronald
authors.initials: GR
authors.lastname: Beck
authors.forename: Lynn
authors.initials: L
authors.lastname: Liu
authors.forename: John D
authors.initials: JD
authors.lastname: Bisognano
mesh_terms: D045422:Continuous Positive Airway Pressure / Q000379:methods*; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D015201:Meta-Analysis as Topic; D016032:Randomized Controlled Trials as Topic; D020181:Sleep Apnea, Obstructive / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*