[Association of interleukin-13 gene polymorphisms with atopic bronchial asthma].
A comparative analysis of allele and genotype distribution of C(-1055)T and R130Q IL13 gene polymorphisms has been performed in Russian patients from the Moscow region. In the study, 283 DNA specimens of atopic bronchial asthma (BA) patients and 227 DNA specimens of healthy donors were used. No association of these markers with ABA development as well as with total IgE concentration has been found. Haplotype frequency analysis did not reveal significant difference between samples. However, significant association ofC(-1055)Tpolymorphism with the disease severity has been revealed (OR = 2.39, 95% confidence interval 1.44-3.98, p = 0.001). Therefore, C(-1055)T polymorphism was shown to be associated with atopic BA progression.
Dmitrieva-Zdorova
E V
EV
Voron'ko
O E
OE
Aksenova
M G
MG
Bodoev
N V
NV
D000328:Adult; D001249:Asthma / Q000097:blood / Q000235:genetics / Q000276:immunology*; D018450:Disease Progression; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D018793:Interleukin-13 / Q000235:genetics*; D008297:Male; D009031:Moscow; D011110:Polymorphism, Genetic; D055815:Young Adult
D005819:Genetic Markers; D007070:Immunoglobulin A; D018793:Interleukin-13