Fungal toxins and multiple sclerosis: a compelling connection.
Multiple sclerosis occurs as a consequence of central nervous system neuronal demyelination. Decades of research suggest that the primary suspects (e.g., viruses, genes, immune system) are associative rather than causative agents, but a surprisingly coherent relationship can be made between multiple sclerosis and fungal toxins. Specifically, certain pathogenic fungi sequester in non-neuronal tissue and release toxins that target and destroy CNS astrocytes and oligodendrocytes. Without these glial support cells, myelin degrades triggering the onset of multiple sclerosis and its associated symptoms. We propose here that fungal toxins are the underlying cause of multiple sclerosis and thus may offer an avenue towards an effective cure.
Purzycki
Catherine B
CB
Department of Biology, Rutgers, The State University of New Jersey, 315 Penn Street, Camden, NJ 08102, United States. c.purzyc@usp.edu
Shain
Daniel H
DH
D000818:Animals; D005658:Fungi / Q000472:pathogenicity*; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D009183:Mycotoxins / Q000276:immunology / Q000633:toxicity*; D009457:Neuroglia / Q000187:drug effects / Q000382:microbiology
D009183:Mycotoxins