Sterile inflammatory responses mediated by the NLRP3 inflammasome.
Through pattern recognition receptors the innate immune system detects disruption of the normal function of the organism and initiates responses directed at correcting these derangements. Cellular damage from microbial or non-microbial insults causes the activation of nucleotide-binding domain leucine-rich repeat containing receptors in multiprotein complexes called inflammasomes. Here we discuss the role of the NLRP3 inflammasome in the recognition of cellular damage and the initiation of sterile inflammatory responses.
Cassel
Suzanne L
SL
Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA, USA. Suzanne-cassel@uiowa.edu
Sutterwala
Fayyaz S
FS
D000818:Animals; D002352:Carrier Proteins / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D046912:Multiprotein Complexes / Q000276:immunology*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein
D002352:Carrier Proteins; D046912:Multiprotein Complexes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human