title: The effects of a lupin-enriched diet on oxidative stress and factors influencing vascular function in overweight subjects.
abstract: A diet enriched in lupin kernel flour can lower blood pressure, but mechanisms responsible are unclear. Lupin is a source of polyphenols, protein, and L-arginine, factors that may influence blood pressure via effects on oxidative stress and vascular function. Therefore, we aimed to determine the effects of a lupin-enriched diet on oxidative stress and factors influencing vascular function as potential mechanisms for demonstrated benefits on blood pressure. Overweight men and women (n = 88) were recruited to a 16-week parallel-design study. Participants were randomly assigned to replace 15%-20% of their usual daily energy intake with white bread (control) or lupin kernel flour-enriched bread (lupin). All measurements were taken at baseline and 16 weeks. At baseline, plasma F₂-isoprostanes and 20-hydroxyeicosatetraenoic acid (20-HETE) were positively associated with blood pressure, and plasma nitrite was negatively associated with blood pressure (p < 0.05). For lupin relative to control, the estimated differences in plasma F₂-isoprostanes (45 pmol/L; 95%CI: -68, 158), urinary F₂-isoprostanes (17 pmol/mmol creatinine; 95%CI: -43, 76), plasma 20-HETE (75 pmol/L; 95%CI: -91, 241), and plasma nitrite (-0.3 μmol/L; 95%CI: -1.1, 0.4) were not significant. Although regular consumption of lupin-enriched bread can lower blood pressure, these results do not support for the hypothesis that this is via effects on oxidative stress or vascular function.
authors.affiliation: School of Medicine and Pharmacology, University of Western Australia, and the WAIMR Centre for Food and Genomic Medicine, Perth, Western Australia, Australia.
authors.forename: Xingbin
authors.initials: X
authors.lastname: Yang
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Croft
authors.forename: Ya P
authors.initials: YP
authors.lastname: Lee
authors.forename: Trevor A
authors.initials: TA
authors.lastname: Mori
authors.forename: Ian B
authors.initials: IB
authors.lastname: Puddey
authors.forename: Sofia
authors.initials: S
authors.lastname: Sipsas
authors.forename: Anne
authors.initials: A
authors.lastname: Barden
authors.forename: Ewald
authors.initials: E
authors.lastname: Swinny
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Hodgson
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects* / Q000502:physiology; D004032:Diet; D028441:F2-Isoprostanes / Q000097:blood / Q000652:urine; D005260:Female; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000097:blood; D031297:Lupinus; D008297:Male; D008875:Middle Aged; D009573:Nitrites / Q000097:blood; D050177:Overweight; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D028321:Plant Preparations / Q000008:administration & dosage / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D028441:F2-Isoprostanes; D006893:Hydroxyeicosatetraenoic Acids; D009573:Nitrites; D028321:Plant Preparations; C055987:20-hydroxy-5,8,11,14-eicosatetraenoic acid