Subtle BBB alterations in brain edema associated with acute liver failure.
Vasogenic mechanism of brain edema in acute liver failure (ALF) remains poorly understood. Recent work demonstrates that matrix metalloproteinase-9 (MMP-9) contributes to the development of brain edema in experimental ALF (J Hepatol 44:1105, 2006). Importantly, MMP-9 blockage with specific monoclonal antibodies and/or synthetic inhibitor, the edema is attenuated. Specifically, utrastructural evaluations demonstrate intact blood-brain barrier and its tight junction. These results suggest that subtle alterations in BBB are likely to involve in the brain edema associated with ALF.
Nguyen
Justin H
JH
D000818:Animals; D001397:Azoxymethane / Q000494:pharmacology; D001812:Blood-Brain Barrier; D001929:Brain Edema / Q000201:enzymology / Q000503:physiopathology*; D017114:Liver Failure, Acute / Q000503:physiopathology*; D061965:Matrix Metalloproteinase Inhibitors; D051379:Mice; D008854:Microscopy, Electron
D061965:Matrix Metalloproteinase Inhibitors; D001397:Azoxymethane