Cu(II)-mediated methylthiolation of aryl C-H bonds with DMSO.
An unprecedented Cu(II)-mediated methylthiolation of aryl C-H bonds under oxidative conditions that employs the widely available DMSO as the methylthiolation reagent is described. Various functional groups in the substrates were tolerated, and ethylthiolation was also successfully achieved directly from diethyl sulfoxide under the same reaction conditions.
Chu
Lingling
L
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China.
Yue
Xuyi
X
Qing
Feng-Ling
FL
D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004121:Dimethyl Sulfoxide / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013454:Sulfoxides / Q000737:chemistry
D013438:Sulfhydryl Compounds; D013454:Sulfoxides; C454662:diethyl sulfoxide; D003300:Copper; D004121:Dimethyl Sulfoxide