title: Oxazolomycins: natural product lead structures for novel antibacterials by click fragment conjugation.
abstract: Conjugation of amide and lactam subunits by a 'Click' type approach provides access to structural mimics of the oxazolomycin series of natural products, some of which exhibit antibacterial activity.
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.
authors.forename: Claire L
authors.initials: CL
authors.lastname: Bagwell
authors.forename: Mark G
authors.initials: MG
authors.lastname: Moloney
authors.forename: Muhammad
authors.initials: M
authors.lastname: Yaqoob
mesh_terms: D000577:Amides / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001424:Bacterial Infections / Q000188:drug therapy; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects*; D006801:Humans; D007769:Lactams / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry* / Q000494:pharmacology*; D011760:Pyrrolidinones; D013141:Spiro Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
chemical_list: D000577:Amides; D000900:Anti-Bacterial Agents; D001688:Biological Products; D007769:Lactams; D010080:Oxazoles; D011760:Pyrrolidinones; D013141:Spiro Compounds; C077919:diffusomycin