Amphetamine toxicities: classical and emerging mechanisms.
The drugs of abuse, methamphetamine and MDMA, produce long-term decreases in markers of biogenic amine neurotransmission. These decreases have been traditionally linked to nerve terminals and are evident in a variety of species, including rodents, nonhuman primates, and humans. Recent studies indicate that the damage produced by these drugs may be more widespread than originally believed. Changes indicative of damage to cell bodies of biogenic and nonbiogenic amine-containing neurons in several brain areas and endothelial cells that make up the blood-brain barrier have been reported. The processes that mediate this damage involve not only oxidative stress but also include excitotoxic mechanisms, neuroinflammation, the ubiquitin proteasome system, as well as mitochondrial and neurotrophic factor dysfunction. These mechanisms also underlie the toxicity associated with chronic stress and human immunodeficiency virus (HIV) infection, both of which have been shown to augment the toxicity to methamphetamine. Overall, multiple mechanisms are involved and interact to promote neurotoxicity to methamphetamine and MDMA. Moreover, the high coincidence of substituted amphetamine abuse by humans with HIV and/or chronic stress exposure suggests a potential enhanced vulnerability of these individuals to the neurotoxic actions of the amphetamines.
Yamamoto
Bryan K
BK
Department of Neurosciences, University of Toledo College of Medicine, Toledo, Ohio 43614, USA. bryan.yamamoto@utoledo.edu
Moszczynska
Anna
A
Gudelsky
Gary A
GA
D000662:Amphetamines / Q000633:toxicity*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D000697:Central Nervous System Stimulants / Q000633:toxicity*; D015658:HIV Infections / Q000150:complications / Q000503:physiopathology; D006801:Humans; D013287:Illicit Drugs / Q000633:toxicity*; D008694:Methamphetamine / Q000633:toxicity; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000633:toxicity; D018384:Oxidative Stress / Q000187:drug effects; D013312:Stress, Physiological; D019966:Substance-Related Disorders / Q000150:complications / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology
D000662:Amphetamines; D000697:Central Nervous System Stimulants; D013287:Illicit Drugs; D008694:Methamphetamine; D018817:N-Methyl-3,4-methylenedioxyamphetamine