[Meta-analyses of oxaliplatin-based chemotherapy versus cisplatin-based chemotherapy in advanced gastric cancer].
OBJECTIVE
To analyze whether Oxaliplatin (OXA) is effective in advanced gastric cancer.


METHODS
Clinical trials of OXA-based chemotherapy (treatment group) versus DDP-based chemotherapy (control group) in advanced gastric cancer which published in 6 years were retrieved from China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP information database and PubMed of U.S. National Library of Medicine and NIH. Review Manager 4.2 was used for meta-analysis and main outcome measure included objective response rate, survival and toxicities.


RESULTS
There were 2121 patients (1062 cases in treatment group and 1059 cases in control group) from 16 controlled clinical trials were enrolled. Response rate increased (46.3% vs 40.6%, OR = 1.28, P = 0.006) and 1-year survival rate increased (44.6% vs 39.3%, OR = 1.25, P = 0.04) in treatment group than that of control group. Peripheral neurotoxicity was more frequently observed in treatment group (70.6% vs 21.9%, OR = 10.76, P < 0.01) while anemia and nausea/vomiting were reversed (58.0% vs 70.1%, 61.4% vs 75.6% respectively, both P < 0.05).


CONCLUSIONS
Oxaliplatin-based chemotherapy is well-tolerated and more effective than cisplatin in advanced gastric cancer.
Gong
Ji-fang
JF
Department of Gastrointestinal Oncology, Key Laboratory of Carcinogenesis and Translational Research under Ministry of Education, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing 100142, China.
Shen
Lin
L
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D018849:Controlled Clinical Trials as Topic; D006801:Humans; D015201:Meta-Analysis as Topic; D009367:Neoplasm Staging; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D002945:Cisplatin