title: Store-operated calcium entry channels in pulmonary endothelium: the emerging story of TRPCS and Orai1.
abstract: Cells of diverse origin utilize shifts in cytosolic calcium concentrations as intracellular signals to elicit physiological responses. In endothelium, inflammatory first messengers increase cytosolic calcium as a signal to disrupt cell-cell borders and produce inter-cellular gaps. Calcium influx across the plasma membrane is required to initiate barrier disruption, although the calcium entry mechanism responsible for this effect remains poorly understood. This chapter highlights recent efforts to define the molecular anatomy of the ion channel responsible for triggering endothelial cell gap formation. Resolving the identity and function of this calcium channel will pave the way for new anti-inflammatory therapeutic targets.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of South Alabama, Mobile, AL, 46688, USA.
authors.forename: Donna L
authors.initials: DL
authors.lastname: Cioffi
authors.forename: Christina
authors.initials: C
authors.lastname: Barry
authors.forename: Troy
authors.initials: T
authors.lastname: Stevens
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism*; D002463:Cell Membrane Permeability; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000378:metabolism; D008168:Lung / Q000098:blood supply / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D015398:Signal Transduction / Q000502:physiology; D050052:TRPC Cation Channels / Q000235:genetics / Q000378:metabolism*; D019284:Thapsigargin / Q000378:metabolism
chemical_list: D015220:Calcium Channels; D004791:Enzyme Inhibitors; D050052:TRPC Cation Channels; D019284:Thapsigargin; D002118:Calcium