Reaction of isocyanides with thiophenols and gem-diactivated olefins: a one-pot synthesis of substituted 2-aminopyrroles.
A novel multicomponent reaction of isocyanides with thiophenols and gem-diactivated olefins has been discovered. Depending on the choice of isocyanides, substituted 2-aminopyrroles or thioimidates have been prepared. The obtained scaffolds bearing four points of diversity can directly be used in combinatorial syntheses.
Kolontsova
Anna N
AN
Department of Technology for Organic Synthesis, TOSLab, Ural State Technical University, 620002 Ekaterinburg, Russian Federation.
Ivantsova
Maria N
MN
Tokareva
Maria I
MI
Mironov
Maxim A
MA
D000475:Alkenes / Q000737:chemistry*; D002625:Chemistry, Organic / Q000379:methods*; D003486:Cyanides / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D000475:Alkenes; D003486:Cyanides; D010636:Phenols; D011758:Pyrroles; D013438:Sulfhydryl Compounds; C042983:thiophenol