Mutations in Keap1 are a potential prognostic factor in resected non-small cell lung cancer.
BACKGROUND
Mutations in Kelch-like ECH-associated protein 1 (Keap1) have been reported to protect tumor cells from chemotherapeutic agents. However, their prognostic significance in nonsmall cell lung cancer (NSCLC) is still unclear. In this study, we examined the effect of Keap1 gene mutations on survival and disease-free interval using resected primary NSCLC tissue.


METHODS
We retrospectively analyzed the tumors from 79 patients with completely resected pathological Stage I-II NSCLC for the presence of Keap1 gene mutations and examined the prognosis of the patients.


RESULTS
Keap1 gene mutations were detected in four patients (5.1%). The postoperative 5-year survival rate for patients with Keap1 mutations was significantly lower than those without a mutation (25% vs. 76%, P = 0.038). The postoperative 5-year disease-free survival rate for patients with a mutant Keap1 tumor was slightly lower than for patients with Keap1 wild-type tumors (25% vs. 66%, P = 0.057).


CONCLUSIONS
Keap1 gene mutations are likely to be associated with a worse prognosis and lower postoperative disease-free survival rates in pathological Stage I-II NSCLC.
Takahashi
Tsuyoshi
T
Faculty of Medicine, Department of Thoracic Surgery, Kyoto University, Sakyo-Ku, Kyoto, Japan.
Sonobe
Makoto
M
Menju
Toshi
T
Nakayama
Ei
E
Mino
Nobuya
N
Iwakiri
Shotaro
S
Nagai
Shinjiro
S
Sato
Kiyoshi
K
Miyahara
Ryo
R
Okubo
Kenichi
K
Hirata
Toshiki
T
Date
Hiroshi
H
Wada
Hiromi
H
D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000401:mortality*; D018076:DNA, Complementary / Q000032:analysis; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011379:Prognosis; D012189:Retrospective Studies; D012907:Smoking; D015996:Survival Rate
D018076:DNA, Complementary