title: Testosterone concentrations in diabetic and nondiabetic obese men.
abstract: OBJECTIVE
  To determine the prevalence of subnormal testosterone concentrations in patients with obesity and with type 2 diabetes in a primary care clinic population.
  
  
  METHODS
  Free testosterone concentrations of 1,849 men (1,451 nondiabetic and 398 diabetic) in the Hypogonadism In Males (HIM) study were analyzed. The HIM study was a U.S.-based cross-sectional study designed to define the prevalence of hypogonadism in men aged >45 years. Free testosterone was measured by equilibrium dialysis.
  
  
  RESULTS
  The prevalence of subnormal free testosterone concentrations in lean, overweight, and obese nondiabetic men was 26% (n = 275), 29% (n = 687), and 40% (n = 489), respectively (P < 0.001 for trend), and 44% (n = 36), 44% (n = 135), and 50% (n = 227), respectively, in diabetic men (P = 0.46 for trend within group and P < 0.05 compared with nondiabetic men). The mean free testosterone concentration of diabetic men was significantly lower than that of nondiabetic men. Free testosterone concentrations were negatively and significantly (P < 0.001) related to age (r = -0.37), BMI (r = -0.18), and sex hormone-binding globulin (r = -0.11) in multiple regression analysis. The average decline of free testosterone concentrations was 7.8 pg/ml per decade in nondiabetic men and 8.4 pg/ml per decade in diabetic men.
  
  
  CONCLUSIONS
  Forty percent of obese nondiabetic men and 50% of obese diabetic men aged >or=45 years have subnormal free testosterone concentrations. In view of its high prevalence, obesity is probably the condition most frequently associated with subnormal free testosterone concentrations in males. The concomitant presence of diabetes is associated with an additional increase in the prevalence of subnormal free testosterone concentrations.
authors.affiliation: Division of Endocrinology, Diabetes and Metabolism, State University of New York at Buffalo, New York, USA.
authors.forename: Sandeep
authors.initials: S
authors.lastname: Dhindsa
authors.forename: Michael G
authors.initials: MG
authors.lastname: Miller
authors.forename: Cecilia L
authors.initials: CL
authors.lastname: McWhirter
authors.forename: Donald E
authors.initials: DE
authors.lastname: Mager
authors.forename: Husam
authors.initials: H
authors.lastname: Ghanim
authors.forename: Ajay
authors.initials: A
authors.lastname: Chaudhuri
authors.forename: Paresh
authors.initials: P
authors.lastname: Dandona
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D013739:Testosterone / Q000097:blood*
chemical_list: D013739:Testosterone