title: In vitro and in vivo evaluation of the efficacy of bovine colostrum against human rotavirus infection.
abstract: We found that skimmed and concentrated bovine late colostrum (SCBLC) obtained from normal cows at 6-7 d after parturition exhibited high potency in inhibiting replication of human rotavirus (HRV) in vitro. Furthermore, prophylactic oral administration of SCBLC once before inoculation of HRV prevented the development of diarrhea in suckling mice in vivo. SCBLC from normal cows might be useful in the prevention of HRV-induced severe gastroenteritis in immunocompromised hosts.
authors.affiliation: United Graduate School of Agricultural Science, Gifu University, Yanagido, Gifu, Japan.
authors.forename: Mizuho
authors.initials: M
authors.lastname: Inagaki
authors.forename: Mayumi
authors.initials: M
authors.lastname: Yamamoto
authors.lastname: Xijier
authors.lastname: Cairangzhuoma
authors.forename: Kenji
authors.initials: K
authors.lastname: Uchida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamaguchi
authors.forename: Mihoko
authors.initials: M
authors.lastname: Kawasaki
authors.forename: Kousaku
authors.initials: K
authors.lastname: Yamashita
authors.forename: Tomio
authors.initials: T
authors.lastname: Yabe
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kanamaru
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D002417:Cattle; D003126:Colostrum / Q000276:immunology*; D003967:Diarrhea / Q000276:immunology / Q000517:prevention & control; D005260:Female; D005759:Gastroenteritis / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D051379:Mice; D011247:Pregnancy; D012401:Rotavirus / Q000502:physiology; D012400:Rotavirus Infections / Q000276:immunology / Q000517:prevention & control*; D014779:Virus Replication