Supplementation of deprenyl attenuates age associated alterations in rat cerebellum.
Aging, a multifactorial process of enormous complexity is characterised by physio-chemical and biological aspects of cellular functions. It is closely associated with changes in metabolism of various biological molecules in the system. In the present study, we have investigated the effect of deprenyl on cerebellum during ageing process in male Wistar rats with respect to the changes in levels of protein, glycoproteins and amino acids in experimental rats of three age groups (6, 12 and 18 months old). Intraperitoneal administration of liquid deprenyl (2 mg/kg body weight/day for a period of 15 days i.p., significantly P < 0.05) attenuated age-associated alterations in the levels of amino acids (taurine, aspartate, glutamate, arginine, hydroxy proline and homocysteine), protein content and glycoprotein components (hexose and hexosamine) in the rat cerebellum. The results of the present investigation indicate that the protective effect of deprenyl is probably related to its ability to strengthen the neuronal membrane by its membrane stabilizing action or to a counteraction of free radicals by its antioxidant property.
Subramanian
Manju V
MV
Division of Neurobiology and Ageing, Department of Zoology, Sacred Heart College, Cochin, 682013, India. manjuvs@yahoo.com
James
T J
TJ
D000375:Aging / Q000187:drug effects* / Q000502:physiology*; D000818:Animals; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D019587:Dietary Supplements; D006595:Hexosamines / Q000378:metabolism; D006601:Hexoses / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011689:Purkinje Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012642:Selegiline / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*
D006595:Hexosamines; D006601:Hexoses; D012642:Selegiline