Experimental infection of squirrel monkeys with nipah virus.
We infected squirrel monkeys (Saimiri sciureus) with Nipah virus to determine the monkeys' suitability for use as primate models in preclinical testing of preventive and therapeutic treatments. Infection of squirrel monkeys through intravenous injection was followed by high death rates associated with acute neurologic and respiratory illness and viral RNA and antigen production.
Marianneau
Philippe
P
Institut Pasteur, Lyon, France.
Guillaume
Vanessa
V
Wong
Thong
T
Badmanathan
Munisamy
M
Looi
Ren Yih
RY
Murri
Severine
S
Loth
Philippe
P
Tordo
Noel
N
Wild
Fabian
F
Horvat
Branka
B
Contamin
Hugues
H
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000096:biosynthesis; D004195:Disease Models, Animal; D045464:Henipavirus Infections / Q000401:mortality / Q000503:physiopathology* / Q000821:virology; D006801:Humans; D045405:Nipah Virus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D012367:RNA, Viral / Q000096:biosynthesis; D012453:Saimiri / Q000821:virology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D012367:RNA, Viral