Anti-inflammatory properties of bioactive titanium metals.
Anti-inflammatory properties of bioactive titanium metals prepared by anodic oxidation (AO-Ti) and alkali-heat (AH-Ti) treatments were studied by bacterial adhesion test and myeloperoxidase (MPO) activity assay methods. The bioactivities of the metals were also evaluated by apatite formation ability and osteoblasts culture experiments. Both metals could induce apatite formation and support osteoblasts proliferation. At the condition with normal incandescent light shine, both bioactive titanium metals had antibacterial adhesion properties compared with the titanium metal without treatment. The MPO activity assay proved that they both showed anti-inflammatory properties in vivo. The bioactive AO-Ti had better anti-inflammatory properties than the AH-Ti. It indicated that it is possible to optimize the anti-inflammatory properties of the bioactive titanium metals by different preparation methods.
Yang
Bangcheng
B
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, China. yangbchengc@126.com
Gan
Lu
L
Qu
Yang
Y
Yue
Chongxia
C
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D001031:Apatites / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism; D001672:Biocompatible Materials / Q000378:metabolism*; D002460:Cell Line; D002478:Cells, Cultured; D008422:Materials Testing; D008670:Metals / Q000378:metabolism*; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D013499:Surface Properties; D014025:Titanium / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D001031:Apatites; D001672:Biocompatible Materials; D008670:Metals; D014025:Titanium; D009195:Peroxidase