title: EC-IC bypass function in Moyamoya disease and non-Moyamoya ischemic stroke evaluated by intraoperative indocyanine green fluorescence angiography.
abstract: Indocyanine green (ICG) emits near-infrared fluorescence when it is excited by near-infrared light. The near infrared fluorescence of ICG was applied to the imaging of cerebral vessels during neurosurgical operations such as clipping of aneurysms. In this study, ICG angiography was applied to extracranial-intracranial (EC-IC) bypass surgery to evaluate the hemodynamic changes induced by bypass in moyamoya disease (MD) and non-moyamoya ischemic diseases (non-MD). These patients underwent superficial temporal artery-middle cerebral artery (STA-MCA) anastomosis. We compared the cortical areas where the bypass supplied blood flow between MD and non-MD. ICG angiography clearly demonstrated the bypass blood flow from the anastomosed STA to the cortical vessels including arteries, capillaries, and veins in both MD and non-MD. Interestingly, the anastomosed STA supplied blood flow to a larger cortical area in MD than non-MD. The bypass supplied greater extent of blood flow to the ischemic brain in MD than in non-MD. This difference might be caused by the fact that the perfusion pressure was lower in MD than in non-MD.
authors.affiliation: Division of Neurosurgery, Department of Neurological Surgery, Nihon University School of Medicine, Tokyo, Japan. awntkyk1556@yahoo.co.jp
authors.forename: Takayuki
authors.initials: T
authors.lastname: Awano
authors.forename: Kaoru
authors.initials: K
authors.lastname: Sakatani
authors.forename: Noriaki
authors.initials: N
authors.lastname: Yokose
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Hoshino
authors.forename: Norio
authors.initials: N
authors.lastname: Fujiwara
authors.forename: Shin
authors.initials: S
authors.lastname: Nakamura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Murata
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Kano
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Katayama
authors.forename: Takahiro
authors.initials: T
authors.lastname: Shikayama
authors.forename: Mitsuharu
authors.initials: M
authors.lastname: Miwa
mesh_terms: D000714:Anastomosis, Surgical; D002545:Brain Ischemia / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002548:Cerebral Revascularization / Q000379:methods*; D005451:Fluorescein Angiography / Q000379:methods*; D006801:Humans; D007208:Indocyanine Green; D007430:Intraoperative Care; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000601:surgery; D009072:Moyamoya Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D011859:Radiography; D020521:Stroke / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D013699:Temporal Arteries / Q000601:surgery; D055815:Young Adult
chemical_list: D007208:Indocyanine Green