title: The feasibility study of docetaxel in patients with anaplastic thyroid cancer.
abstract: There is no established chemotherapy for anaplastic thyroid cancer. We conducted a prospective feasibility study at a single center to explore the antitumor activity of docetaxel against anaplastic thyroid cancer. Docetaxel was administered intravenously at a dose of 60 mg/m(2) over the course of 1 h every 3 weeks in patients with anaplastic thyroid cancer who had received no prior chemotherapy. A total of seven patients with anaplastic thyroid cancer were enrolled over the course of 30 months and received docetaxel. The treatment response was complete response in one patient, stable disease in two and progressive disease in four. The response rate was 14%, and the disease control rate (complete response plus stable disease) was 43%. The median time to progression was 6 weeks (range, 1-50). Toxicity was tolerable. Docetaxel could be an effective drug for the treatment of anaplastic thyroid cancer, with tolerable toxicity.
authors.affiliation: Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Japan. kekawada@nagoya-1st.jrc.or.jp
authors.forename: Kenji
authors.initials: K
authors.lastname: Kawada
authors.forename: Koichi
authors.initials: K
authors.lastname: Kitagawa
authors.forename: Sachi
authors.initials: S
authors.lastname: Kamei
authors.forename: Megumi
authors.initials: M
authors.lastname: Inada
authors.forename: Ayako
authors.initials: A
authors.lastname: Mitsuma
authors.forename: Masataka
authors.initials: M
authors.lastname: Sawaki
authors.forename: Toyone
authors.initials: T
authors.lastname: Kikumori
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Arima
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Imai
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ando
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002277:Carcinoma / Q000188:drug therapy* / Q000473:pathology; D018450:Disease Progression; D000077143:Docetaxel; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D043823:Taxoids / Q000008:administration & dosage* / Q000009:adverse effects; D013964:Thyroid Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D043823:Taxoids; D000077143:Docetaxel