Microbial metabolism of cannflavin A and B isolated from Cannabis sativa.
Microbial metabolism of cannflavin A (1) and B (2), two biologically active flavonoids isolated from Cannabis sativa L., produced five metabolites (3-7). Incubation of 1 and 2 with Mucor ramannianus (ATCC 9628) and Beauveria bassiana (ATCC 13144), respectively, yielded 6''S,7''-dihydroxycannflavin A (3), 6''S,7''-dihydroxycannflavin A 7-sulfate (4) and 6''S,7''-dihydroxycannflavin A 4'-O-alpha-L-rhamnopyranoside (5), and cannflavin B 7-O-beta-D-4'''-O-methylglucopyranoside (6) and cannflavin B 7-sulfate (7), respectively. All compounds were evaluated for antimicrobial and antiprotozoal activity.
Ibrahim
Amany K
AK
Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
Radwan
Mohamed M
MM
Ahmed
Safwat A
SA
Slade
Desmond
D
Ross
Samir A
SA
ElSohly
Mahmoud A
MA
Khan
Ikhlas A
IA
D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D052982:Beauveria / Q000378:metabolism*; D002188:Cannabis / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009089:Mucor / Q000378:metabolism*; D021261:Parasitic Sensitivity Tests
D000890:Anti-Infective Agents; D000981:Antiprotozoal Agents; D047309:Flavones; C045457:cannflavin