title: [Immunoglobulins G, A, M and circulatory immune complexes in patients with laryngeal carcinoma].
abstract: BACKGROUND
  Malignant tumors of the head and neck represent 5% of all malignancies, of which the most common are tumors of the larynx and oral cavity. In the blood serum of patients with malignant tumors increased levels of immunoglobulins and circulating immune complexes have been detected, with a diverse relevance to the clinical course and prognosis of the disease.
  
  
  OBJECTIVE
  Due to contradictory findings of the correlation between the humoral immune response and the clinical course of the disease, we examined 42 male patients with laryngeal carcinoma. All patients underwent surgery, of which 15 patients were treated postoperatively with radiotherapy. The changes in the levels of immunoglobulins and circulating immune complexes in the blood serum were recorded and evaluated.
  
  
  RESULTS
  Analysis of the results showed an immunological disorder of an abnormal level of circulating immune complexes in the blood serum that normalized after the surgical removal of the tumor. The levels of immunoglobulins G and A were abnormal during the whole postoperative period of examination.
  
  
  CONCLUSIONS
  The normalizing of the levels of circulating immune complexes in the blood serum, after surgical removal of the tumor, shows a strong association between the two, and this could consequently mean that it could be used as a prognostic tool, particularly in correlation with other immunological parameters.
authors.affiliation: KC Srbije, Klinika za ORL i maksilofacijalnu hirurgiju, Univerzitet u Beogradu, Medicinski fakultet, Beograd, Srbija.
authors.forename: M V
authors.initials: MV
authors.lastname: Dimitrijević
authors.forename: V
authors.initials: V
authors.lastname: Djordević
authors.forename: N
authors.initials: N
authors.lastname: Arsović
authors.forename: P D
authors.initials: PD
authors.lastname: Jeremić
authors.forename: N A
authors.initials: NA
authors.lastname: Slijepcević
authors.forename: G
authors.initials: G
authors.lastname: Konjević
mesh_terms: D000936:Antigen-Antibody Complex / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007136:Immunoglobulins / Q000097:blood*; D007822:Laryngeal Neoplasms / Q000276:immunology* / Q000628:therapy; D008297:Male
chemical_list: D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins