Pancreatic cancer: pathobiology, treatment options, and drug delivery.
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the USA. The high mortality rate is partly due to lack of effective treatments. This review summarizes the pathobiology and current treatment options for pancreatic cancer. Moreover, the review discusses the opportunities of developing novel therapies for pancreatic cancer provided by the progress in understanding the genetic mutations, tumor microenvironment, cancer stem cells, and drug delivery.
Li
Jing
J
College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA.
Wientjes
M Guillaume
MG
Au
Jessie L-S
JL
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D018450:Disease Progression; D016503:Drug Delivery Systems; D006801:Humans; D014411:Neoplastic Stem Cells / Q000502:physiology; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D033581:Stem Cell Transplantation
D000970:Antineoplastic Agents