title: Cell culture and motility study on a polymer surface with a nanometer-scaled stripe structure.
abstract: We developed a large cell culture surface with a nanostripe structure by paving polydimethylsiloxane (PDMS) replicas of a glass mold. The stripe structure has a height of 180 nm and top width of 500 nm with 400-nm intervals between stripes. Human stomach cancer SH-10-TC cells cultured on the surface changed their morphology to elongated shapes parallel to the nanostripes. In addition, cell motility parallel to the stripes was greatly enhanced. These findings strongly suggest that the nanostripe structure affected the cell physiology.
authors.affiliation: Department of Applied Biological Chemistry, School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Kiichi
authors.initials: K
authors.lastname: Sato
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Abo
authors.forename: Takehiko
authors.initials: T
authors.lastname: Tsukahara
authors.forename: Takehiko
authors.initials: T
authors.lastname: Kitamori
authors.forename: Keiko
authors.initials: K
authors.lastname: Abe
authors.forename: Etsuro
authors.initials: E
authors.lastname: Yoshimura
mesh_terms: D002448:Cell Adhesion; D018929:Cell Culture Techniques; D002465:Cell Movement; D004129:Dimethylpolysiloxanes / Q000138:chemical synthesis / Q000737:chemistry*; D005898:Glass; D006801:Humans; D049329:Nanostructures; D014407:Tumor Cells, Cultured
chemical_list: D004129:Dimethylpolysiloxanes