Global Origin of Mycobacterium tuberculosis in the Midlands, UK.
DNA fingerprinting data for 4,207 Mycobacterium tuberculosis isolates were combined with data from a computer program (Origins). Largest population groups were from England (n = 1,031) and India (n = 912), and most prevalent strains were the Euro-American (45%) and East African-Indian (34%) lineages. Combining geographic and molecular data can enhance cluster investigation.
Evans
Jason T
JT
Health Protection Agency West Midlands Laboratory, Birmingham, UK.
Gardiner
Sarah
S
Smith
E Grace
EG
Webber
Richard
R
Hawkey
Peter M
PM
D001208:Asia / Q000453:epidemiology; D015373:Bacterial Typing Techniques; D016172:DNA Fingerprinting; D030561:Databases, Nucleic Acid; D005060:Europe / Q000453:epidemiology; D006801:Humans; D007194:India / Q000453:epidemiology; D018598:Minisatellite Repeats / Q000235:genetics; D017720:Molecular Epidemiology; D009169:Mycobacterium tuberculosis / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics; D014397:Tuberculosis, Pulmonary / Q000453:epidemiology* / Q000382:microbiology; D006113:United Kingdom / Q000453:epidemiology