Liposomal circular dichroism. Assignment of remote stereocenters in plakinic acids K and L from a Plakortis-Xestospongia sponge association.
Two new omega-phenyl polyketide peroxides, plakinic acids K and L, were isolated from a two-sponge association of Plakortis halichondroides and Xestospongia deweerdtae. The absolute configurations of the remote dimethyl-branched stereocenters in plakinic acid K were assigned by degradation of plakinic acid K to a long-chain naphthamide and analysis by liposomal circular dichroism (L-CD) and comparison with synthetic standards.
Dalisay
Doralyn S
DS
Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
Quach
Tim
T
Molinski
Tadeusz F
TF
D000818:Animals; D002942:Circular Dichroism; D008081:Liposomes / Q000737:chemistry*; D008968:Molecular Conformation; D010545:Peroxides / Q000737:chemistry* / Q000302:isolation & purification; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism
D008081:Liposomes; D010545:Peroxides; C550219:plakinic acid K; C550220:plakinic acid L