[New polyphenolic extracts for oxidative stress treatment in experimental diabetes].
The paper focuses on the extraction and purification by chromatographic and spectral methods of certain natural polyphenolic extracts from Aronia melanocarpa and common elder (Sambuccus nigra) fruit, and also on their effects in hypoinsulinemic diabetes mellitus.


METHODS
The research was made upon Wistar rats, which were divided into 4 groups: group I--control group; group II--with polyphenols in a dose of 0.034 g/body-kg; group III--with diabetes mellitus, induced by 55 mg/body-kg of streptozotocyne; group IV--to whom was administered a solution of polyphenols, 12 weeks, after the onset of diabetes mellitus.


RESULTS
Glycosylated hemoglobin values are much higher in the diabetic group and they are significantly lower in the group protected by polyphenols. The serous activity of glutathione-peroxidase and superoxide-dismutase has significantly lower values in the diabetic group as compared to the group protected by polyphenols. The serous concentration of malondialdehyde in the diabetic group undergoing polyphenols treatment is lower as compared to the diabetic group, which means a significant decrease of lipid peroxides in the serum. The results demonstrate the hypoglycemic, hypolipemic and antioxidant effects of Aronia melanocarpa and Sambucus nigra extracts in streptozocin-induced diabetes.
Ciocoiu
Manuela
M
Facultatea de Medicină, Disciplina de Fiziopatologie, Universitatea de Medicină si Farmacie "Gr. T. Popa" Iaşi.
Miron
Anca
A
Bădescu
Magda
M
D000818:Animals; D002845:Chromatography; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D006442:Glycated Hemoglobin / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D018384:Oxidative Stress / Q000187:drug effects*; D010636:Phenols / Q000494:pharmacology / Q000627:therapeutic use*; D046936:Photinia; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000627:therapeutic use; D059808:Polyphenols; D051381:Rats; D017208:Rats, Wistar; D027924:Sambucus nigra; D013057:Spectrum Analysis; D016896:Treatment Outcome
D005419:Flavonoids; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols