title: Preview. Angelman syndrome: finding the lost arc.
abstract: Angelman syndrome is a neurodevelopmental disorder caused by mutations in the maternally inherited UBE3A gene, which encodes a ubiquitin ligase. Greer et al. (2010) now identify a UBE3A substrate called Arc that promotes endocytosis of neuronal AMPA receptors, providing insight into synaptic defects that may underlie the cognitive deficits in Angelman syndrome.
authors.affiliation: Division of Biology, Caltech, Pasadena, CA 91125, USA.
authors.forename: Hwan-Ching
authors.initials: HC
authors.lastname: Tai
authors.forename: Erin M
authors.initials: EM
authors.lastname: Schuman