[Effect of tissue inhibitors of metalloproteinases (TIMP) on course and prognosis of head and neck squamous cell carcinoma].
The paper compares the levels of TIMP-1 and TIMP-2 in blood serum from patients with head and neck squamous cell carcinoma (HNSCC) to establish correlations with clinico-morphological parameters of the disease and prognosis. Our study involved 140 patients with HNSCC (T1-3N0-3M0) and 38 healthy donors. The level of serum TIMP-1 in patients was significantly higher (p < or = 0.02) while that of TIMP-2 was in inverse correlation with histological grade of tumor (p < or = 0.04) and age (p < or = 0.05). High level of TIMP-1 appeared an unfavorable prognosticator for 2-year relapse-free survival in HNSCC patients (p < or = 0.05). Those of both TIMP-1 and TIMP-2 identified in blood serum prior to therapy involved high risk of metastasis development (p < or = 0.05) and (p < or = 0.05), respectively.
Klisho
E V
EV
Kondakova
I V
IV
Choĭnzonov
E L
EL
Shishkin
D A
DA
Cheremisina
O V
OV
Chuzhevskaia
S Iu
SIu
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D014019:Tissue Donors; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood*; D019716:Tissue Inhibitor of Metalloproteinase-2 / Q000097:blood*
D014408:Biomarkers, Tumor; D019715:Tissue Inhibitor of Metalloproteinase-1; D019716:Tissue Inhibitor of Metalloproteinase-2