title: A long-term follow-up study on endoscopic management of children and adolescents with chronic pancreatitis.
abstract: OBJECTIVE
  Data on therapeutic endoscopic retrograde cholangiopancreatography (ERCP) for chronic pancreatitis (CP) in children and adolescents, especially with long-term follow-up of consequences, are rarely reported. The aim of this study was to determine the long-term follow-up results of therapeutic ERCP for CP in children and adolescents.
  
  
  METHODS
  All patients with CP who received therapeutic ERCP at Changhai Hospital from January 1997 to May 2009, with the age at first onset of pain being less than 18.0 years, were included. Attempts were made to contact all adolescents and follow-up data were recorded. Clinical data were assessed before and after every ERCP.
  
  
  RESULTS
  Follow-up information was available in 42 (91.3%) of the 46 patients who received therapeutic ERCP. There were 20 boys and 22 girls, with the age at first onset being 11.8+/-4.5 years. A total of 110 therapeutic ERCP sessions were performed in the 42 patients. The post-ERCP complication rate was 17.3%, including mild and moderate pancreatitis (n=17) and mild cholangitis (n=2). The mean follow-up period of time was 61.4 (range: 24-132) months. Five patients underwent subsequent surgery because of refractory abdominal pain after endotherapy. Of the remaining 37 patients who received therapeutic ERCP alone, abdominal pain improved in 30 (81.1%) patients, and was completely relieved in 24 (64.9%) patients during the period of follow-up.
  
  
  CONCLUSIONS
  Therapeutic ERCP may offer long-term improvement in pain in children and adolescents with CP.
authors.affiliation: Chronic Pancreatic Study Group, Department of Gastroenterology, Digestive Endoscopy Center, Changhai Hospital, The Second Military Medical University, Shanghai, China. zhaoshenli@hotmail.com
authors.forename: Zhao-Shen
authors.initials: ZS
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Zhuan
authors.initials: Z
authors.lastname: Liao
authors.forename: Duo-Wu
authors.initials: DW
authors.lastname: Zou
authors.forename: Zhen-Dong
authors.initials: ZD
authors.lastname: Jin
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Ren-Pei
authors.initials: RP
authors.lastname: Wu
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Luo-Wei
authors.initials: LW
authors.lastname: Wang
authors.forename: Xin-Gang
authors.initials: XG
authors.lastname: Shi
authors.forename: Zhao
authors.initials: Z
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D002648:Child; D002760:Cholangiopancreatography, Endoscopic Retrograde / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010186:Pancreatic Function Tests; D050500:Pancreatitis, Chronic / Q000628:therapy*; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers