Structure elucidation of new oleanane-type glycosides from three species of Acanthophyllum.
From the roots of three species of Acanthophyllum (Caryophyllaceae), two new gypsogenic acid glycosides, 1 and 2, were isolated, 1 from A. sordidum and A. lilacinum, 2 from A. elatius and A. lilacinum, together with three known saponins, glandulosides B and C, and SAPO50. The structures of 1 and 2 were established mainly by 2D NMR techniques as 23-O-beta-D-galactopyranosylgypsogenic acid-28-O-beta-D-glucopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->6)]-beta-D-galactopyranoside (1) and gypsogenic acid-28-O-beta-D-glucopyranosyl-(1-->3)-[beta-D-glucopyranosyl-(1-->6)]-beta-D-galactopyranoside (2). The cytotoxicity of several of these saponins was evaluated against two human colon cancer cell lines (HT-29 and HCT 116).
Timité
Gaoussou
G
Laboratoire de Pharmacognosie, UMIB, UPRES EA 3660, Faculté de Pharmacie, Université de Bourgogne, 7 bd. Jeanne D' Arc, BP 87900, 21079 Dijon Cedex, France.
Mitaine-Offer
Anne-Claire
AC
Miyamoto
Tomofumi
T
Ramezani
Mohammad
M
Rustaiyan
Abdolhossein
A
Mirjolet
Jean-François
JF
Duchamp
Olivier
O
Lacaille-Dubois
Marie-Aleth
MA
D002236:Carbohydrate Conformation; D029748:Caryophyllaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D013045:Species Specificity
C413246:oleanane; D009828:Oleanolic Acid