title: Two cases of congenital retrobulbar cyst or peripapillary staphyloma with an alcoholic mother.
abstract: The authors report two cases of congenital retrobulbar cyst or large peripapillary staphyloma with alcoholic mothers. In the first case, a 53-day-old newborn was referred for evaluation of microphthalmia in her left eye. Ophthalmic examination showed microcornea, microphthalmia, and an abnormally enlarged optic disc with an excavation in her left eye. Imaging revealed the presence of a cystic lesion in her left orbit that seemed to be communicated with the vitreous cavity. She did not have chromosomal abnormality. In the second case, a large peripapillary staphyloma was detected in the right eye of a 7-month-old newborn. The mother of each patient was an alcoholic. Retrobulbar cystic lesion or peripapillary staphyloma could be considered to be a series of abnormalities caused by the degree of the failure of the optic cup. Effects of each mother's alcohol intake on the development of the eye, especially the closure of the optic cup, is to be further investigated.
authors.affiliation: Department of Ophthalmology, Wakayama Medical University, 811-1 Kimiidera, Wakayama, 641-0012, Japan.
authors.forename: Ai
authors.initials: A
authors.lastname: Kitano
authors.forename: Kumi
authors.initials: K
authors.lastname: Shirai
authors.forename: Yuka
authors.initials: Y
authors.lastname: Okada
authors.forename: Shizuya
authors.initials: S
authors.lastname: Saika
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D003560:Cysts; D005128:Eye Diseases; D005260:Female; D006801:Humans; D007223:Infant; D009898:Optic Disk / Q000002:abnormalities*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects