Brevibacillus expression system: host-vector system for efficient production of secretory proteins.
Brevibacillus expression system is an effective bacterial expression system for secretory proteins. The host bacterium, Brevibacillus choshinensis, a gram-positive bacterium, has strong capacity to secrete a large amount of proteins (approximately 30 g/L), which mostly consist of cell wall protein. A host-vector system that utilizes such high expression capacity has been constructed for the production of secretory proteins and tested for various heterologous proteins, including cytokines, enzymes, antigens, and adjuvants.
Mizukami
Makoto
M
Bio Research Group, R&D Department, Higeta Shoyu Co. Ltd., 2-8 Chuo-Cho, Choshi-shi, Chiba 288-8680, Japan.
Hanagata
Hiroshi
H
Miyauchi
Akira
A
D001951:Brevibacterium / Q000502:physiology*; D024861:Genetic Enhancement / Q000379:methods*; D005822:Genetic Vectors / Q000235:genetics*; D015202:Protein Engineering / Q000379:methods*; D011994:Recombinant Proteins / Q000378:metabolism*
D011994:Recombinant Proteins