title: Melanocytic bronchopulmonary carcinoid tumor in a patient with multiple endocrine neoplasia syndrome type 1: a case report with emphasis on intraoperative cytological findings.
abstract: We present the cytological features along with histologic and imaging findings of a melanocytic bronchopulmonary carcinoid tumor in a patient with multiple endocrine neoplasia syndrome type 1 (MEN-1). Intraoperative touch preparations of the lung tumor showed single spindle cells and loosely cohesive aggregates of spindle cells with oval to elongated nuclei, "salt and pepper" chromatin pattern and inconspicuous nucleoli. The spindle cells occasionally contained cytoplasmic pigment, which revealed to be melanin by Fontana Masson stain on permanent processed material. Immunohistochemical stains for both synaptophysin and chromogranin were strongly positive in the spindle cells. The findings were consistent with melanocytic bronchopulmonary carcinoid tumor, which is relatively uncommon in MEN-1.
authors.affiliation: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors.forename: Kant M
authors.initials: KM
authors.lastname: Matsuda
authors.forename: Raíssa
authors.initials: R
authors.lastname: Nóbrega
authors.forename: Martha
authors.initials: M
authors.lastname: Quezado
authors.forename: David S
authors.initials: DS
authors.lastname: Schrump
authors.forename: Armando C
authors.initials: AC
authors.lastname: Filie
mesh_terms: D000328:Adult; D002276:Carcinoid Tumor / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007432:Intraoperative Period; D008175:Lung Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008544:Melanocytes / Q000473:pathology*; D018761:Multiple Endocrine Neoplasia Type 1 / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography