Weight gain and insulin resistance in children treated with valproate: the influence of time.
This study was undertaken in 2 parts to investigate the relationship between body size and insulin resistance during treatment with valproic acid in children. The cross-sectional part revealed differences in terms of body size and homeostasis model assessment of insulin resistance, which were higher in the group on medication. The longitudinal part showed a major increase in body size and insulin resistance during the first year of therapy. There was a subsequent decrease in insulin resistance in association with the rise of body size, however with a trend to level off. These results might be helpful to enhance the knowledge of valproic acid action on both insulin resistance and weight gain, allowing to plan appropriate approach for the prevention of the consequences of the treatment with valproic acid.
Masuccio
Fabio
F
Department of Pediatrics, University of Chieti, Chieti, Italy.
Verrotti
Alberto
A
Chiavaroli
Valentina
V
de Giorgis
Tommaso
T
Giannini
Cosimo
C
Chiarelli
Francesco
F
Mohn
Angelika
A
D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006706:Homeostasis / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008137:Longitudinal Studies; D008297:Male; D009765:Obesity / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology*; D011446:Prospective Studies; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D015430:Weight Gain / Q000187:drug effects* / Q000502:physiology
D000927:Anticonvulsants; D014635:Valproic Acid