Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity.
Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome) are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and hyperleptinemia protect lipid-intolerant nonadipose organs against lipotoxic lipid spillover during sustained caloric surplus. Metabolic syndrome is ascribed to lipotoxicity caused by age-related resistance to antilipotoxic protection by leptin.
Unger
Roger H
RH
Department of Internal Medicine, University of Texas Southwestern Medical Center, Touchstone Center for Diabetes Research, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA. Roger.Unger@utsouthwestern.edu
Scherer
Philipp E
PE
D000273:Adipose Tissue / Q000378:metabolism* / Q000503:physiopathology; D002149:Energy Intake / Q000502:physiology; D006801:Humans; D006963:Hyperphagia / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D020738:Leptin / Q000097:blood / Q000502:physiology; D008055:Lipids / Q000009:adverse effects* / Q000097:blood; D024821:Metabolic Syndrome / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology; D009765:Obesity / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology
D020738:Leptin; D008055:Lipids