title: A novel approach to evaluate the vessel function determined by near infrared spectroscopy.
abstract: The purpose of this study was to evaluate arterial function by near infrared spectroscopy (NIRS). 16 elderly subjects were studied: 8 were arteriosclerosis obliterans patients (ASO), and 8 were healthy elderly (non-ASO). A cuff around the thigh was inflated to a pressure of 20% above their ankle systolic blood pressure for 3 min. The NIRS probe was positioned over the gatrocnemius muscle to measure oxygenated hemoglobin (O(2)Hb), and the recovery time and rate for DeltaO(2)Hb after occlusion were calculated. Compared with the non-ASO group, the ASO group had a longer recovery time (p < 0.05) and a shallower recovery rate gradient (p < 0.01). The ankle to brachial index was correlated with recovery time (r = -0.61, p < 0.01) and recovery rate (r = 0.80, p < 0.001). These data suggest that NIRS may provide an effective non-invasive method for evaluating arterial function in patients with arteriosclerosis obliterans.
authors.affiliation: Laboratory for Applied Physiology, University of Tokushima, Tokushima, Japan. hajime-m@ias.tokushima-u.ac.jp
authors.forename: Hajime
authors.initials: H
authors.lastname: Miura
authors.forename: Nao
authors.initials: N
authors.lastname: Okumura
mesh_terms: D000368:Aged; D001161:Arteriosclerosis / Q000503:physiopathology; D001808:Blood Vessels / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D010108:Oxyhemoglobins / Q000378:metabolism; D019265:Spectroscopy, Near-Infrared / Q000379:methods*
chemical_list: D010108:Oxyhemoglobins