title: CD40mAb adjuvant induces a rapid antibody response that may be beneficial in post-exposure prophylaxis.
abstract: Active vaccination can be effective as a post-exposure prophylaxis, but the rapidity of the immune response induced, relative to the incubation time of the pathogen, is critical. We show here that CD40mAb conjugated to antigen induces a more rapid specific antibody response than currently used immunological adjuvants, alum and monophosphoryl lipid A.
authors.affiliation: Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
authors.forename: Vijay Ns
authors.initials: VN
authors.lastname: Bhagawati-Prasad
authors.affiliation: Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
authors.forename: Evy
authors.initials: E
authors.lastname: De Leenheer
authors.affiliation: Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
authors.forename: Nadine P
authors.initials: NP
authors.lastname: Keefe
authors.affiliation: Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
authors.forename: Lorna A
authors.initials: LA
authors.lastname: Ryan
authors.affiliation: Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.
authors.forename: Jennifer
authors.initials: J
authors.lastname: Carlring
authors.affiliation: Department of Infection and Immunity, University of Sheffield Medical School, Beech Hill Rd, Sheffield S10 2RX, UK.|Adjuvantix Ltd, c/o Fusion plc, Sheffield Bioincubator, Leavygreave Rd, Sheffield, UK.
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Heath