P-170 peptides with low similarity to the human proteome: tracing an effective and safe biological way towards effective and safe cancer chemotherapy.
We propose low-similarity P-170 peptide-based antibodies to neutralize the multidrug resistance phenomenon and, consequently, improve the treatment regimens for cancer chemotherapy. As a first step in the experimental validation of this approach, we report on the similarity analysis of the P-170 primary amino acid structure versus the human proteome and describe peptide motifs uniquely owned by the human P-170 glycoprotein.
Kanduc
Darja
D
Department of Biochemistry and Molecular Biology "Ernesto Quagliariello", University of Bari, Italy. d.kanduc@biologia.uniba.it
Novello
Giuseppe
G
Mazzanti
Roberto
R
D018435:ATP Binding Cassette Transporter, Subfamily B; D000595:Amino Acid Sequence; D019138:Antibodies, Blocking / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D030562:Databases, Protein; D018432:Drug Resistance, Multiple / Q000187:drug effects*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D000939:Epitopes / Q000235:genetics; D006023:Glycoproteins / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology / Q000494:pharmacology*; D020543:Proteome / Q000737:chemistry*
C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D019138:Antibodies, Blocking; D000970:Antineoplastic Agents; D000939:Epitopes; D006023:Glycoproteins; D010446:Peptide Fragments; D020543:Proteome