title: Comparison of the effectiveness of 2 treatment regimens in patients with isoniazid-resistant tuberculosis.
abstract: We compared the effectiveness of 2 treatment regimens for isoniazid-resistant tuberculosis (TB) in 42 patients attending a TB referral centre in the Islamic Republic of Iran. The patients were divided into 2 treatment groups: 26 received the 6-month standard HRZE treatment and 16 received a modified treatment of RZE for 6 months. There were no significant differences in age or sex of the groups. With the standard method of treatment, 21 (80.8%) patients were cured, 4 (15.4%) resulted in treatment failure, and 1 (3.8%) died. In the modified treatment group, 16 (100%) patients were cured, These differences were not statistically significantly different (P = 0.194).
authors.affiliation: Mycobacteriology Research Centre, National Research Institute of Tuberculosis and Lung Disease, Shaheed Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran. tabarsi@nritld.ac.ir
authors.forename: P
authors.initials: P
authors.lastname: Tabarsi
authors.forename: P
authors.initials: P
authors.lastname: Baghaei
authors.forename: N
authors.initials: N
authors.lastname: Hemmati
authors.forename: M
authors.initials: M
authors.lastname: Mirsaeidi
authors.forename: M
authors.initials: M
authors.lastname: Kazempour
authors.forename: D
authors.initials: D
authors.lastname: Mansouri
authors.forename: M R
authors.initials: MR
authors.lastname: Masjedi
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D004977:Ethambutol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D007538:Isoniazid / Q000627:therapeutic use*; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011718:Pyrazinamide / Q000627:therapeutic use*; D012189:Retrospective Studies; D012293:Rifampin / Q000627:therapeutic use*; D013183:Sputum / Q000382:microbiology; D013307:Streptomycin; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents; D011718:Pyrazinamide; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin