MARCH-I: a new regulator of dendritic cell function.
We and other groups have demonstrated that the expression level of MHC class II (MHC II) is regulated through ubiquitination of the MHC II beta chain. We also reported that MARCH-I, an E3 ubiquitin ligase, is critical for this process. At present, however, the importance of MARCH-I-mediated MHC II regulation in vivo is still unknown. In this review, we will summarize recent advances in our understanding of MARCH-I-mediated MHC II ubiquitination, and discuss how we can overcome the difficulties inherent in these studies.
Ishido
Satoshi
S
Laboratory for Infectious Immunity, RIKEN Research Center for Allergy and Immunology, Yokohama, Kanagawa, 230-0045, Japan. ishido@rcai.riken.jp
Matsuki
Yohei
Y
Goto
Eiji
E
Kajikawa
Mizuho
M
Ohmura-Hoshino
Mari
M
D000818:Animals; D017951:Antigen Presentation / Q000502:physiology*; D003713:Dendritic Cells / Q000201:enzymology / Q000502:physiology*; D055879:Gene Knock-In Techniques; D005802:Genes, MHC Class II; D000949:Histocompatibility Antigens Class II / Q000737:chemistry / Q000276:immunology / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D008221:Lymphoid Tissue / Q000201:enzymology / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D011499:Protein Processing, Post-Translational / Q000502:physiology; D044767:Ubiquitin-Protein Ligases / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D054875:Ubiquitination
D000949:Histocompatibility Antigens Class II; C545340:MARCH1 protein, mouse; D044767:Ubiquitin-Protein Ligases