title: Acute postoperative seizures after epilepsy surgery - a long-term outcome predictor?
abstract: OBJECTIVE
  The prognostic value of acute postoperative seizures (APS) after epilepsy surgery is much debated. This study evaluated APS, defined as seizures in the first week post-surgery, as a predictor of long-term seizure outcome, and investigated the utility of other potential outcome predictors.
  
  
  METHODS
  Medical records of 48 patients with temporal and extra-temporal epilepsy surgery were studied. Forty patients had lesional surgery. All had at least 2 year postoperative follow-up.
  
  
  RESULTS
  At 2 year follow-up, 25 patients (53%) were seizure free. Univariate analysis showed that APS (P = 0.048), using ≥ six AEDs prior to surgery (P = 0.03), pathological postoperative EEG (P = 0.043) and female gender (P = 0.012) were associated with seizure recurrence.
  
  
  CONCLUSIONS
  Univariate analysis indicate that APS, a high number of AEDs used prior to surgery, and pathological postoperative EEG are possible predictors of seizure recurrence after epilepsy surgery. Only gender retained significance in the multivariate analysis.
authors.affiliation: National Centre for Epilepsy, Rikshospitalet University Hospital, Oslo, Norway. kristin.alfstad@epilepsy.no
authors.forename: K Å
authors.initials: KÅ
authors.lastname: Alfstad
authors.forename: M I
authors.initials: MI
authors.lastname: Lossius
authors.forename: G K
authors.initials: GK
authors.lastname: Røste
authors.forename: P
authors.initials: P
authors.lastname: Mowinckel
authors.forename: D
authors.initials: D
authors.lastname: Scheie
authors.forename: O C
authors.initials: OC
authors.lastname: Borota
authors.forename: P G
authors.initials: PG
authors.lastname: Larsson
authors.forename: K O
authors.initials: KO
authors.lastname: Nakken
mesh_terms: D000328:Adult; D004827:Epilepsy / Q000601:surgery; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009664:Norway; D016017:Odds Ratio; D011183:Postoperative Complications / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies; D012640:Seizures / Q000175:diagnosis / Q000209:etiology*; D016896:Treatment Outcome; D055815:Young Adult