[In vitro investigation of Ingavirin efficacy against influenza B virus].
The experimental investigation of Ingavirin activity against influenza B virus showed that in concentrations 100 and 200 mcg/ml it was efficient in inhibition of the virus reproduction: the cytopathic effect was lowered by 75%, the level of the pathogen accumulation in the MDCK cell culture was decreased by more than 2.0 lg and the formation of the virus specific hemagglutinin was inhibited by more than 90%.
Loginova
S Ia
SIa
Borisevich
S V
SV
Semenova
I A
IA
Borisevich
G V
GV
Maksimov
V A
VA
Bondarev
V P
VP
Nebol'sin
V E
VE
D000577:Amides / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002208:Caproates; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D003998:Dicarboxylic Acids / Q000494:pharmacology*; D004285:Dogs; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000096:biosynthesis; D007093:Imidazoles / Q000494:pharmacology*; D009981:Influenza B virus / Q000187:drug effects* / Q000502:physiology; D014779:Virus Replication / Q000187:drug effects
D000577:Amides; D000998:Antiviral Agents; D002208:Caproates; D003998:Dicarboxylic Acids; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D007093:Imidazoles; C539419:pentanedioic acid imidazolyl ethanamide