title: Novel epothilone lactones by an unusual diversion of the Grubbs' metathesis reaction.
abstract: An unusual reaction with Grubbs' catalyst during the synthesis of bridged epothilones yielded five-membered internal lactones instead of the expected metathesis products. Three of the lactones have activities comparable to epothilone D.
authors.affiliation: Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
authors.forename: Qiao-Hong
authors.initials: QH
authors.lastname: Chen
authors.forename: Thota
authors.initials: T
authors.lastname: Ganesh
authors.forename: Yi
authors.initials: Y
authors.lastname: Jiang
authors.forename: Abhijit
authors.initials: A
authors.lastname: Banerjee
authors.forename: Shubhada
authors.initials: S
authors.lastname: Sharma
authors.forename: Susan
authors.initials: S
authors.lastname: Bane
authors.forename: James P
authors.initials: JP
authors.lastname: Snyder
authors.forename: David G I
authors.initials: DG
authors.lastname: Kingston
mesh_terms: D003500:Cyclization; D034261:Epothilones / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular
chemical_list: D034261:Epothilones; D007783:Lactones