A concise synthesis of enantiopure circumdatins E, H and J.
A concise total synthesis of enantiopure circumdatins E, H and J has been developed using a reductive cyclization of chiral N-prolinoyl-2-nitrobenzamides to construct the core quinazolinone ring.
Zhichkin
Paul E
PE
Medicinal Chemistry Department, AMRI, 26 Corporate Circle P.O. Box 15098, Albany, New York 12212, USA. Paul.Zhichkin@amriglobal.com
Jin
Xiaomin
X
Zhang
Honglu
H
Peterson
Lisa H
LH
Ramirez
Catherine
C
Snyder
Tara M
TM
Burton
Hilde S
HS
D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000737:chemistry*; D052999:Quinazolinones / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
D001570:Benzodiazepinones; D052999:Quinazolinones; C549826:circumdatin E; C504253:circumdatin H; C549827:circumdatin J