title: Possible neuropsychiatric reaction to high-dose oseltamivir during acute 2009 H1N1 influenza A infection.
abstract: The safety of high-dose oseltamivir during treatment of 2009 H1N1 influenza A infection for critically ill patients is unknown. Here we report on a case patient with severe, delayed-onset neuropsychiatric symptoms after administration of high-dose oseltamivir. Clinicians should be vigilant to the possible increased risk of complications associated with high-dose oseltamivir therapy for 2009 H1N1 influenza A infection.
authors.affiliation: School of Medicine, University of California, San Francisco, California, USA.
authors.forename: Kenta
authors.initials: K
authors.lastname: Nakamura
authors.forename: Brian S
authors.initials: BS
authors.lastname: Schwartz
authors.forename: Niklas
authors.initials: N
authors.lastname: Lindegårdh
authors.forename: Chris
authors.initials: C
authors.lastname: Keh
authors.forename: B Joseph
authors.initials: BJ
authors.lastname: Guglielmo
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D003221:Confusion / Q000139:chemically induced; D006212:Hallucinations / Q000139:chemically induced; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D015473:Leukemia, Promyelocytic, Acute / Q000150:complications / Q000628:therapy; D008297:Male; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D053139:Oseltamivir / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D014182:Transplantation, Autologous
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir