title: In vivo experimental study of hat type cervical intervertebral fusion cage (HCIFC).
abstract: The purpose of this study was to compare the characteristics of interbody fusion achieved using the hat type cervical intervertebral fusion cage (HCIFC) with those of an autologous tricortical iliac crest graft, Harms cage and the carbon cage in a goat cervical spine model. Thirty-two goats underwent C3-4 discectomy and fusion. They were subdivided into four groups of eight goats each: group 1, autologous tricortical iliac crest bone graft; group 2, Harms cage filled with autologous iliac crest graft; group 3, carbon cage filled with autologous iliac bone; and group 4, HCIFC filled with autologous iliac graft. Radiography was performed pre- and postoperatively and after one, two, four, eight and 12 weeks. At the same time points, disc space height, intervertebral angle, and lordosis angle were measured. After 12 weeks, the goats were killed and fusion sites were harvested. Biomechanical testing was performed in flexion, extension, axial rotation, and lateral bending to determine the stiffness and range of motion. All cervical fusion specimens underwent histomorphological analyses. One week after operation, the disc space height (DSH), intervertebral angle (IVA) and lordosis angle (LA) of HCIFC and carbon cage were statistically greater than those of autologous iliac bone graft and Harms cage. Significantly higher values for DSH, IVA and LA were shown in cage-treated goats than in those that received bone graft over a 12-week period. The stiffness of Harms cage in axial rotation and lateral bending were statistically greater than that of other groups. Radiographic and histomorphological evaluation showed better fusion results in the cage groups than in the autologous bone group. HCIFC can provide a good intervertebral distractability and sufficient biomechanical stability for cervical fusion.
authors.affiliation: Department of Orthopaedics, Zhongshan Hospital of Fudan University, Shanghai, China. gyt633@sohu.com
authors.forename: Yu-tong
authors.initials: YT
authors.lastname: Gu
authors.forename: Zhen-jun
authors.initials: ZJ
authors.lastname: Yao
authors.forename: Lian-shun
authors.initials: LS
authors.lastname: Jia
authors.forename: Jin
authors.initials: J
authors.lastname: Qi
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D016025:Bone Transplantation; D002574:Cervical Vertebrae / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D004195:Disease Models, Animal; D017586:Diskectomy / Q000379:methods; D006041:Goats; D016268:Internal Fixators; D007403:Intervertebral Disc / Q000473:pathology / Q000601:surgery*; D008297:Male; D016348:Osseointegration; D011474:Prosthesis Design; D011475:Prosthesis Failure; D011859:Radiography; D013123:Spinal Fusion / Q000295:instrumentation* / Q000379:methods