title: [Preparation and in vitro release characteristics of curcumin loaded biodegradable microspheres].
abstract: OBJECTIVE
  To prepare curcumin-loaded poly-(D,L-lactide-co-glycolide) microspheres and study its release characteristics in vitro.
  
  
  METHODS
  Curcumin-loaded poly-(D,L-lactide-co-glycolide) microspheres were prepared by W/O/W emulsification solvent-evaporation process. The microspheres were characterized in terms of morphology, size, encapsulation efficiency, the rate of drug loading and in vitro drug release.
  
  
  RESULTS
  The formed microspheres were spherical with smooth surfaces. The distribution of particle size was uniform and average size was 1 151 nm. The rate of drug loading was (1.98 +/- 0.14)% and the encapsulation efficiency was (59.44 +/- 4.05)%. In vitro release study revealed that the 71-hour accumulative release percentage reached 77%.
  
  
  CONCLUSIONS
  Curcumin loaded poly-(D,L-lactide-co-glycolide) microspheres are prepared successfully and show good sustained-release characteristics.
authors.affiliation: Chongqing Key Laboratory of Biochemistry & Molecular Pharmacology, School of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Haiou
authors.initials: H
authors.lastname: Wang
authors.forename: Pan
authors.initials: P
authors.lastname: Li
authors.forename: Liangke
authors.initials: L
authors.lastname: Zhang
authors.forename: Jingqing
authors.initials: J
authors.lastname: Zhang
authors.forename: Xu
authors.initials: X
authors.lastname: Ling
authors.forename: Haitao
authors.initials: H
authors.lastname: Ran
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D003474:Curcumin / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size; D011098:Polyglactin 910 / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D011098:Polyglactin 910; D003474:Curcumin