Feasibility of image-guided robotic radiotherapy using three fractions for uveal melanoma.
OBJECTIVE
A retrospective study was performed to demonstrate the feasibility and efficacy of 3-fraction image-guided robotic stereotactic radiotherapy (fSRT) for uveal melanoma.


METHODS
Six patients with medium-sized or large tumors, who declined enucleation, were enrolled. The gross tumor volume (GTV) ranged from 454 to 2185 mm3. The total doses included 36 or 39 Gy in 3 fractions.


RESULTS
Follow-up ranged from 19 to 40 months. In 5 patients, the tumor mass gradually underwent an average 24.5% size reduction. All 3 patients with a GTV <1000 mm3 had a functional eye, while 3 patients with a GTV > or = 1000 mm3 did not have a functional eye. Radiation-induced complications occurred to some degree in all patients. However, complications that required enucleation were not detected.


CONCLUSIONS
We suggest that image-guided robotic radiotherapy using 3 fractions is a feasible and safe treatment option for patients with uveal melanoma. In cases of medium-sized and large tumors, fSRT could be used as an alternative treatment for cases ineligible for brachytherapy, but a longer follow-up and a larger number of patients are required to confirm the suitability of the method.
Choi
Sang Yul
SY
Department of Ophthalmology, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea.
Kim
Mi-Sook
MS
Yoo
Sung Yul
SY
Cho
Chul Koo
CK
Lhee
Chang Hoon
CH
Lee
Dong Han
DH
Kang
Jin Kyu
JK
Shin
Young-Joo
YJ
D000328:Adult; D000368:Aged; D019583:Dose Fractionation, Radiation; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000532:radiotherapy / Q000601:surgery*; D008875:Middle Aged; D016634:Radiosurgery; D011879:Radiotherapy Dosage; D012371:Robotics; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014604:Uveal Neoplasms / Q000532:radiotherapy / Q000601:surgery*