[Renal expression of macrophage migration inhibitory factor in children with Henoch-Sch-nlein purpura nephritis].
OBJECTIVE
To examine the expression of macrophage migration inhibitory factor (MIF) in renal tissues obtained from children with Henoch-Sch-nlein purpura nephritis (HSPN).


METHODS
The renal tissue samples were obtained from 11 children with different pathological grades of HSPN and 8 children with thin glomerular basement membrane disease (controls). The MIF expression was measured by immunohistochemistry. The correlation between MIF expression and 24 hrs urinary protein excretions was evaluated using a linear correlation analysis.


RESULTS
MIF expression was seldom found in renal tissues obtained from controls. However, a significantly increased MIF expression was found and was concordant with the increased severity of renal pathology in renal tissues obtained from children with HSPN. The MIF expression in renal tissues of grade III-IV of renal pathology was significantly higher than that in grade I-II in children with HSPN (p<0.01). In children with HSPN, there was an increased MIF expression in renal tissues with crescent formation and inflammatory cell infiltration. Renal MIF expression was significantly positively correlated with 24 hrs urinary protein excretions in children with HSPN (p<0.01).


CONCLUSIONS
MIF may play an important role in renal injury of HSPN. Up-regulation of MIF expression may reflect the degree of renal lesions in HSPN.
Zheng
Wen-Jie
WJ
Department of Nephrology, Yuying Children's Hospital Affiliated to Wenzhou Medical College, Wenzhou, Zhejiang, China. wzwjzheng@sina.com
Chen
Min-Guang
MG
Chen
Xiao-Ying
XY
Yang
Qing
Q
Lin
Rui-Xia
RX
D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000378:metabolism* / Q000473:pathology; D007150:Immunohistochemistry; D007668:Kidney / Q000737:chemistry*; D008263:Macrophage Migration-Inhibitory Factors / Q000032:analysis*; D008297:Male; D009393:Nephritis / Q000378:metabolism* / Q000473:pathology; D011507:Proteinuria / Q000209:etiology
D008263:Macrophage Migration-Inhibitory Factors