title: [Main aspects and principles of pharmacotherapy during percutaneous coronary interventions in elderly subjects (over 75 years of age)].
abstract: Indications, contraindications, mortality and complication rates in patients undergoing percutaneous coronary interventions (PCI) are discussed in age-related aspects especially devoted to elderly. Own results of over 10-year-long experience (1998-2008) in interventional cardiology (coronary angiography, percutaneous coronary transluminal angioplasty, stenting) with 192 patients over 75 years of age (from 75 to 93 y. o.) suffering stable, unstable angina or myocardial infarction analyzed in topics of outcomes and perioperative pharmacotherapy. Special aspects of gero-pharmacotherapy based on retrospective analysis of used drugs made it possible to formulate algorithm of intraoperative hypotensive therapy and the six principles of pharmacotherapy in elderly undergoing PCI: 1) do not withdraw the previous therapy until the procedure (except warfarin); 2) therapy individualization due to concomitant diseases; 3) dosage titration starting with of common doses; 4) overwhelming pain control; 5) short acting, having antidotes drugs are preferable just as 6) geroprotective preparations. According to detailed analysis of in-hospital outcomes coronary interventions in elderly are safe enough and may be enough successful.
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Semigolovkiĭ
authors.forename: A L
authors.initials: AL
authors.lastname: Agasiian
authors.forename: A L
authors.initials: AL
authors.lastname: Zagrebin
authors.forename: A V
authors.initials: AV
authors.lastname: Diachuk
authors.forename: K L
authors.initials: KL
authors.lastname: Kozlov
authors.forename: I B
authors.initials: IB
authors.lastname: Oleksiuk
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D000789:Angina, Unstable / Q000628:therapy; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000401:mortality; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000075202:Contraindications; D017023:Coronary Angiography; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy; D017063:Outcome Assessment, Health Care; D012189:Retrospective Studies; D012307:Risk Factors; D012449:Safety; D015607:Stents
chemical_list: D000959:Antihypertensive Agents