title: Subcellular localization of a fluorescent artemisinin derivative to endoplasmic reticulum.
abstract: A cytotoxic artemisinin derivative conjugated with a fluorescent dansyl moiety was synthesized and its subcellular localization in Hep3B cells was examined. Comparison of the localization signals of the fluorescent artemisinin derivative with organelle specific dyes revealed that endoplasmic reticulum (ER) is the main site of its accumulation.
authors.affiliation: Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
authors.forename: Yungen
authors.initials: Y
authors.lastname: Liu
authors.forename: Chun-Nam
authors.initials: CN
authors.lastname: Lok
authors.forename: Ben Chi-Bun
authors.initials: BC
authors.lastname: Ko
authors.forename: Tina Yuen-Ting
authors.initials: TY
authors.lastname: Shum
authors.forename: Man-Kin
authors.initials: MK
authors.lastname: Wong
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
mesh_terms: D000970:Antineoplastic Agents / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D037621:Artemisinins / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D005453:Fluorescence; D006801:Humans; D008968:Molecular Conformation; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents; D037621:Artemisinins; C031327:artemisinin