title: Modeling of 24-hour glucose and insulin profiles of patients with type 2 diabetes.
abstract: A model able to simultaneously characterize and simulate 24-hour glucose and insulin profiles following multiple meal tests was developed, extending an integrated glucose-insulin model for oral glucose tolerance tests that was previously published. The analysis was based on glucose and insulin measurements from 59 placebo-treated patients with type 2 diabetes. Circadian variations in glucose homeostasis were assessed on relevant parameters based on literature review. They were best described by a nighttime dip in insulin secretion between approximately 9 p.m. and 5 a.m. using a modulator function. The integrated glucose-insulin model has thus been shown to be applicable to real-life situations determined by multiple meals over the course of a day. This provides the basis for the analysis and simulation of long-term glucose and insulin data. The model may also prove useful for understanding antidiabetic drug actions and requirements in the context of circadian changes in glucose-insulin regulation.
authors.affiliation: F. Hoffmann-La Roche Ltd, Biomathematics (Modeling & Simulation), PDIM-M, B 015/R 3.032, CH - 4070 Basel, Switzerland. petra.jauslin-stetina@roche.com
authors.forename: Petra M
authors.initials: PM
authors.lastname: Jauslin
authors.forename: Nicolas
authors.initials: N
authors.lastname: Frey
authors.forename: Mats O
authors.initials: MO
authors.lastname: Karlsson
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D002940:Circadian Rhythm; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005260:Female; D005951:Glucose Tolerance Test; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D017711:Nonlinear Dynamics
chemical_list: D001786:Blood Glucose; D007328:Insulin