Integrated equation to evaluate accumulation profiles of drugs eliminated by Michaelis-Menten kinetics.
Using an equation for the calculation of plasma profiles of drug based on the zero-order input and Michaelis-Menten kinetic output in a one-compartment open model system, the times required to reach various degrees of several steady-state plasma concentrations of phenytoin are calculated. The effect of the apparent volume of distribution (due to intersubject variation or change in protein and/or tissue binding, etc.) on the time required to reach various fractions of steady-state plasma concentrations is discussed.
Lam
G
G
Department of Pharmacy, College of Pharmacy, University of Illinois at the Medical Center, Chicago, Illinois 60612, USA.
Chiou
W L
WL
D000465:Algorithms; D000818:Animals; D000927:Anticonvulsants / Q000097:blood / Q000493:pharmacokinetics; D001798:Blood Proteins / Q000378:metabolism; D006801:Humans; D015233:Models, Statistical; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D010672:Phenytoin / Q000097:blood / Q000493:pharmacokinetics; D010949:Plasma / Q000737:chemistry; D011485:Protein Binding
D000927:Anticonvulsants; D001798:Blood Proteins; D004364:Pharmaceutical Preparations; D010672:Phenytoin