SIRT1/eNOS axis as a potential target against vascular senescence, dysfunction and atherosclerosis.
Sir2 (silent information regulator-2), an NAD(+)-dependent histone deacetylase, is highly conserved in organisms ranging from archaea to humans. Yeast Sir2 is responsible for silencing at repeated DNA sequences in mating-type loci, telomeres and rDNA, and plays critical roles in DNA repair, stress resistance and longevity.The phenomenon of human aging is known to be a critical cardiovascular risk factor. Senescence of endothelial cells has been proposed to be involved in vascular dysfunction and atherogenesis. Recent studies have demonstrated that mammalian Sirt1 NAD(+)-dependent protein deacetylase, the closest homologue of Sir2, regulates vascular angiogenesis, homeostasis and senescence. This review focuses on SIRT1 as a potential therapeutic target against atherosclerosis.
Ota
Hidetaka
H
Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Eto
Masato
M
Ogawa
Sumito
S
Iijima
Katsuya
K
Akishita
Masahiro
M
Ouchi
Yasuyoshi
Y
D000375:Aging / Q000502:physiology*; D000818:Animals; D050197:Atherosclerosis / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology; D000077407:Cilostazol; D006706:Homeostasis; D006801:Humans; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism*; D018384:Oxidative Stress; D056564:Sirtuin 1 / Q000378:metabolism*; D013777:Tetrazoles / Q000494:pharmacology*; D015854:Up-Regulation
D013777:Tetrazoles; D052250:Nitric Oxide Synthase Type III; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D000077407:Cilostazol