title: Cold agglutinin induced hemolysis in a newly diagnosed systemic lupus erythematosus.
abstract: Systemic lupus erythematosus (SLE) is a well-known autoimmune chronic inflammatory disease, which can virtually affect any organ system in the body. Although hemolytic anemia has been known to occur in <10% of SLE patients, they are usually mediated through warm antibodies. It is extremely rare to see cold antibody-mediated hemolytic anemia in SLE, and only few cases have been reported in literature to our knowledge. This is a unique case report of SLE associated with cold agglutinin hemolytic anemia in a patient presented with generalized tender lymphadenopathy and typical B-symptoms including fever, night sweats, and significant weight loss.
authors.affiliation: Oklahoma University of Health Sciences Center, Oklahoma City, Oklahoma 73104, USA.
authors.forename: Nandakumar
authors.initials: N
authors.lastname: Srinivasan
authors.forename: Alok
authors.initials: A
authors.lastname: Oswal
authors.forename: Sindhu
authors.initials: S
authors.lastname: Garg
authors.forename: Julie
authors.initials: J
authors.lastname: Nahar
authors.forename: Albina
authors.initials: A
authors.lastname: Gosmonova
authors.forename: Roopesh
authors.initials: R
authors.lastname: Nahar
mesh_terms: D000328:Adult; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis / Q000209:etiology*; D003450:Cryoglobulins / Q000009:adverse effects; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D003450:Cryoglobulins; C029443:cold agglutinins