In vitro and in vivo evaluation of the efficacy of bovine colostrum against human rotavirus infection.
We found that skimmed and concentrated bovine late colostrum (SCBLC) obtained from normal cows at 6-7 d after parturition exhibited high potency in inhibiting replication of human rotavirus (HRV) in vitro. Furthermore, prophylactic oral administration of SCBLC once before inoculation of HRV prevented the development of diarrhea in suckling mice in vivo. SCBLC from normal cows might be useful in the prevention of HRV-induced severe gastroenteritis in immunocompromised hosts.
Inagaki
Mizuho
M
United Graduate School of Agricultural Science, Gifu University, Yanagido, Gifu, Japan.
Yamamoto
Mayumi
M
Xijier
Cairangzhuoma
Uchida
Kenji
K
Yamaguchi
Hiroshi
H
Kawasaki
Mihoko
M
Yamashita
Kousaku
K
Yabe
Tomio
T
Kanamaru
Yoshihiro
Y
D000818:Animals; D000833:Animals, Suckling; D002417:Cattle; D003126:Colostrum / Q000276:immunology*; D003967:Diarrhea / Q000276:immunology / Q000517:prevention & control; D005260:Female; D005759:Gastroenteritis / Q000276:immunology / Q000517:prevention & control; D006801:Humans; D051379:Mice; D011247:Pregnancy; D012401:Rotavirus / Q000502:physiology; D012400:Rotavirus Infections / Q000276:immunology / Q000517:prevention & control*; D014779:Virus Replication