Oligodendrocytes and the "micro brake" of progenitor cell proliferation.
A large fraction of mammalian genes is regulated posttranscriptionally by microRNAs. In the developing nervous system, a small subset of these short RNA molecules is important to orchestrate the rapid switch from OPCs to myelin-forming oligodendrocytes. But putting the miRNA brake on oligodendrocyte gene expression is required throughout life.
Nave
Klaus-Armin
KA
Max-Planck-Institute of Experimental Medicine, Department of Neurogenetics, D-37075 Goettingen, Germany. nave@em.mpg.de
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D009836:Oligodendroglia / Q000166:cytology* / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology*
D035683:MicroRNAs