title: Link between interleukin-10 level and outcome after ischemic stroke.
abstract: OBJECTIVE
  The prognostic value of interleukin (IL)-10 in patients after acute ischemic stroke (IS) is not well understood. This study tested the hypothesis that serum levels of IL-10 are substantially increased after IS and predictive of IS outcome.
  
  
  METHODS
  Serum IL-10 levels were examined 48 h after acute IS in 135 consecutive patients, and in 20 healthy and 30 at-risk controls.
  
  
  RESULTS
  Mean serum IL-10 was significantly higher in IS patients than in both control groups (p < 0.0001, respectively). Additionally, serum IL-10 was significantly higher in patients with severe neurological impairment [defined as a score >or=12 on the National Institute of Health Stroke Scale (NIHSS)] than in patients with less severe neurological impairment (NIHSS score <12) 48 h after IS (p < 0.0001). Furthermore, higher serum IL-10 was strongly and independently correlated with severe neurological impairment (NIHSS >or=12) 48 h after acute IS (p < 0.0001), and independently predictive of combined major adverse clinical outcomes (defined as recurrent IS, any cause of death or NIHSS >or=12) on day 90 following IS (p < 0.0001).
  
  
  CONCLUSIONS
  Serum IL-10 is an independent prognosticator of IS outcome.
authors.affiliation: Division of Basic Medical Science, Department of Nursing, Meiho Institute of Technology, Ping Tung, Taiwan, ROC.
authors.forename: Li-Teh
authors.initials: LT
authors.lastname: Chang
authors.forename: Chun-Man
authors.initials: CM
authors.lastname: Yuen
authors.forename: Chia-Wei
authors.initials: CW
authors.lastname: Liou
authors.forename: Cheng-Hsien
authors.initials: CH
authors.lastname: Lu
authors.forename: Wen-Neng
authors.initials: WN
authors.lastname: Chang
authors.forename: Ali A
authors.initials: AA
authors.lastname: Youssef
authors.forename: Hon-Kan
authors.initials: HK
authors.lastname: Yip
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood* / Q000175:diagnosis / Q000276:immunology*; D004660:Encephalitis / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000032:analysis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011237:Predictive Value of Tests; D011379:Prognosis; D020127:Recovery of Function / Q000276:immunology; D020521:Stroke / Q000097:blood* / Q000175:diagnosis / Q000276:immunology*; D015854:Up-Regulation / Q000276:immunology
chemical_list: D015415:Biomarkers; D016753:Interleukin-10