Distinctive clinical and microscopic features of squamous cell carcinoma of oral cavity and lip.
OBJECTIVE
This study was undertaken to gain insight into the distinctive features of squamous cell carcinoma of the lip (LSCC) and oral cavity (OCSCC).


METHODS
A total of 37 cases of LSCC and 54 of OCSCC were compared regarding clinical and microscopic findings.


RESULTS
Predominance of head and neck TNM stages (HNTNM) T1-T2 in LSCC and T3-T4 in OCSCC was observed. A significant percentage (33.3%) of patients with OCSCC at HNTNM T1-T2 presented cervical lymph node metastasis and 18.75% died, whereas lymph node metastasis was absent and no patient died with LSCC at HNTNM T1-T2. LSCC demonstrated a higher number of cases with intense peritumoral inflammatory infiltrate compared with OCSCC. The analysis of the proliferative index demonstrated a significantly higher percentage of PCNA+ and Ki-67+ cells in OCSCC compared with LSCC.


CONCLUSIONS
Our results suggest that OCSCC and LSCC demonstrate distinct clinical and microscopic characteristics that reflect different biologic behavior and prognosis.
Batista
Aline Carvalho
AC
Department of Stomatology (Oral Pathology), Dental School, Federal University of Goiás, Goiânia, Brazil. ali.caba@uol.com.br
Costa
Nádia Lago
NL
Oton-Leite
Angélica Ferreira
AF
Mendonça
Elismauro Francisco
EF
Alencar
Rita de Cássia Gonçalves
Rde C
Silva
Tarcília Aparecida
TA
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology*; D002452:Cell Count; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008048:Lip Neoplasms / Q000401:mortality / Q000473:pathology*; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality / Q000473:pathology*; D009367:Neoplasm Staging; D016037:Single-Blind Method; D015996:Survival Rate