Shared brain vulnerabilities open the way for nonsubstance addictions: carving addiction at a new joint?
For more than half a century, since the beginning of formal diagnostics, our psychiatric nosology has compartmentalized the compulsive pursuit of substance (e.g., alcohol, cocaine, heroin, nicotine) from nonsubstance (e.g., gambling, food, sex) rewards. Emerging brain, behavioral, and genetic findings challenge this diagnostic boundary, pointing to shared vulnerabilities underlying the pathological pursuit of substance and nonsubstance rewards. Working groups for the fifth revision of the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-V), are thus considering whether the nosologic boundaries of addiction should be redrawn to include nonsubstance disorders, such as gambling. This review discusses how neurobiological data from problem gambling, obesity, and "normal" states of attachment (romantic infatuation, sexual attraction, maternal bonds) may help us in the task of carving addictions "at a new joint." Diagnostic recarving may have a positive effect on addiction research, stimulating discovery of "crossover" pharmacotherapies with benefit for both substance and nonsubstance addictions.
Frascella
Joseph
J
Division of Clinical Neuroscience and Behavioral Research, National Institute on Drug Abuse, Rockville, Maryland, USA.
Potenza
Marc N
MN
Brown
Lucy L
LL
Childress
Anna Rose
AR
D000818:Animals; D016739:Behavior, Addictive / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology / Q000628:therapy; D001921:Brain / Q000503:physiopathology*; D039721:Diagnostic and Statistical Manual of Mental Disorders; D005260:Female; D005715:Gambling / Q000523:psychology; D006801:Humans; D008297:Male; D009765:Obesity / Q000209:etiology / Q000503:physiopathology / Q000523:psychology; D009769:Object Attachment; D010551:Personality; D012201:Reward; D012725:Sexual Behavior / Q000523:psychology