Effects of neurotensin in amygdaloid spatial learning mechanisms.
Neurotensin (NT) acts as a neurotransmitter and/or neuromodulator and plays a role in learning and reward related processes. The central nucleus of amygdala (CeA) participates in the regulation of memory and learning mechanisms. In Morris water maze test, rats were microinjected with NT or neurotensin receptor-1 (NTS1) antagonist SR 48692 (ANT). NT significantly reduced the escape latency. Effect of NT was blocked by ANT pretreatment. Our results show that in the rat CeA NT facilitates spatial learning. We clarified that NTS1s are involved in this action.
László
Kristóf
K
Institute of Physiology, Pécs University Medical School, Pécs, Hungary.
Tóth
Krisztián
K
Kertes
Erika
E
Péczely
László
L
Ollmann
Tamás
T
Lénárd
László
L
D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D004347:Drug Interactions; D008297:Male; D009496:Neurotensin / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D018028:Receptors, Neurotensin / Q000037:antagonists & inhibitors; D013028:Space Perception / Q000187:drug effects*; D018709:Statistics, Nonparametric
D011720:Pyrazoles; D011804:Quinolines; D018028:Receptors, Neurotensin; C079087:SR 48692; D009496:Neurotensin