Malignant peripheral nerve sheath tumor associated with neurofibromatosis type 1, with metastasis to the heart: a case report.
A rare case is presented of a 61-year-old man with a malignant peripheral nerve sheath tumor associated with neurofibromatosis type 1, with metastasis to the heart. The primary tumor originated in the right thigh in 1982. Since then, the patient has had repeated local recurrences in spite of repeated surgical treatment and adjuvant chemotherapy. He has developed previous metastases of the lung and heart. The patient died of cardiac involvement.
Kitamura
Masanori
M
Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, 1-3-3 Nakamichi, Higashinari, Osaka, Japan.
Wada
Naoki
N
Nagata
Shigenori
S
Iizuka
Norishige
N
Jin
Yu-Fen
YF
Tomoeda
Miki
M
Yuki
Michiko
M
Naka
Norifumi
N
Araki
Nobuhito
N
Yutani
Chikao
C
Tomita
Yasuhiko
Y
D000671:Amputation, Surgical; D001344:Autopsy; D001706:Biopsy; D017024:Chemotherapy, Adjuvant; D017809:Fatal Outcome; D006338:Heart Neoplasms / Q000556:secondary* / Q000628:therapy; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018317:Nerve Sheath Neoplasms / Q000556:secondary* / Q000628:therapy; D009456:Neurofibromatosis 1 / Q000473:pathology* / Q000628:therapy; D012983:Soft Tissue Neoplasms / Q000473:pathology* / Q000628:therapy; D013848:Thigh; D016896:Treatment Outcome