Rearrangement strategy for the synthesis of 2-aminoanilines.
Treatment of N-aryl hydroxylamines with trichloroacetonitrile in the presence of imidazole provides a simple and effective method for the preparation of synthetically versatile 2-aminoanilines. Reactions proceed in DMF at 40 degrees C, providing the products in up to 86% isolated yield.
Porzelle
Achim
A
School of Chemistry, Main Building, Cardiff University, Park Place, Cardiff, CF10 3AT, UK.
Woodrow
Michael D
MD
Tomkinson
Nicholas C O
NC
D000814:Aniline Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
D000814:Aniline Compounds