title: Ketosis-onset diabetes in Tunisian adults: immunological markers and beta-cell function.
abstract: The aim of this study in Tunisia was to classify ketosis-onset diabetes in adult patients. All patients aged > 30 years without known diabetes, presenting with ketosis and admitted to our department were studied. Patients with secondary or gestational diabetes and those on corticoid therapy or with coinciding infection were excluded. The data included clinical characteristics, immunological markers and beta-cell function. Of the 63 patients, islet-cell antibodies were present in 27.0%, glutamic acid decarboxylase antibodies in 25.4% and thyrosin phosphatase antibodies in 19.0%. Beta-cell functional reserve was preserved in 54.0%. Our results confirm that patients with ketosis-onset diabetes mellitus in adulthood are a heterogeneous group.
authors.affiliation: Department of Endocrinology and Diabetology, La Rabta Hospital, Tunis, Tunisia. fatma.harzallah@rns.tn
authors.forename: F
authors.initials: F
authors.lastname: Harzallah
authors.forename: A
authors.initials: A
authors.lastname: Ben Brahim
authors.forename: L
authors.initials: L
authors.lastname: Laadhar
authors.forename: M
authors.initials: M
authors.lastname: Feki
authors.forename: M
authors.initials: M
authors.lastname: Zitouni
authors.forename: S
authors.initials: S
authors.lastname: Makni
authors.forename: N
authors.initials: N
authors.lastname: Kaabachi
authors.forename: H
authors.initials: H
authors.lastname: Slimane
mesh_terms: D000208:Acute Disease; D000328:Adult; D017668:Age of Onset; D000704:Analysis of Variance; D001323:Autoantibodies / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D016883:Diabetic Ketoacidosis / Q000097:blood / Q000453:epidemiology* / Q000209:etiology*; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology; D006801:Humans; D050417:Insulin-Secreting Cells / Q000276:immunology; D008297:Male; D008875:Middle Aged; D018709:Statistics, Nonparametric; D014416:Tunisia / Q000453:epidemiology; D014504:Urban Health / Q000706:statistics & numerical data
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; C024211:islet cell antibody; D005968:Glutamate Decarboxylase