[Allosteric plasticity of GABA(A)-receptor and intraneuronal integration by way of transduction signal].
In work the molecular structure and function of GABA(A)-receptor, dependence of allosteric regulation features from subunit composition of receptors are described. Processes of GABAA-receptor plasticity at kindling are described. The process of GABA(A)-receptor allosteric plasticity by pentylenetetrazole (PTZ) kindling induced automodification of receptor activity and consolidated (keeps by means of updating of an expression of genes) its activity. In some days activity of a receptor is restored to a test objective level. In 6 months PTZ subconvulsive dose administration of kindling rats reproduced the severity of seizures and restored of GABA(A)-receptor activity to the level found 6 months before, at the time of termination of kindling, independent of receptor presence activity and age changes. GABA(A)-receptor activity is consolidated by modification of receptor molecule, it is probably by receptor subunit compositions. The study of learning, memory and PTZ amnesia processes have allowed to make a conclusion that similar mechanisms of GABA(A)-receptor plasticity underlie of learning and memory processes. On the basis of the described results the scheme of intraneuronal modulators integration or integration of transduction signals are described.
Bazian
A S
AS
Khashaev
Z Kh
ZKh
D000494:Allosteric Regulation; D000647:Amnesia / Q000503:physiopathology / Q000523:psychology; D000818:Animals; D001921:Brain / Q000502:physiology / Q000503:physiopathology; D007696:Kindling, Neurologic; D007858:Learning / Q000502:physiology; D008568:Memory / Q000502:physiology; D009473:Neuronal Plasticity; D051381:Rats; D011963:Receptors, GABA-A / Q000737:chemistry / Q000502:physiology*; D009435:Synaptic Transmission
D011963:Receptors, GABA-A