title: Chlamydia pneumoniae infection was associated with risk of mortality from coronary heart disease in Japanese women but not men: the JACC Study.
abstract: OBJECTIVE
  To investigate the association between Chlamydia pneumoniae infection and mortality from coronary heart disease, a nested case-control study was conducted for 39,242 Japanese who participated in the JACC Study.
  
  
  METHODS
  Immunoglobulin A and G titers of C. pneumoniae were measured in stored serum samples collected from 209 patients (113 men and 96 women) who subsequently died of coronary heart disease after 13-year follow-up; and 209 controls matched for gender, age (+/-5 years) and area of residence.
  
  
  RESULTS
  After adjustment for high-sensitive CRP and other cardiovascular risk factors, the multivariate odds ratio (OR) of coronary heart disease for highest vs. lowest tertiles of IgA titers was 2.69 (95%CI, 1.00-7.20), p=0.049 for women and 0.58 (0.23-1.46), p=0.25 for men (p for interaction=0.03). A similar association was observed by high (++) vs. low (-/+/-) titers of IgA: multivariate OR was 4.09 (0.86-19.4), p=0.07 for women.
  
  
  CONCLUSIONS
  Since high IgA titers indicate persistent and repeated infection, such a state is associated with an increased risk of coronary heart disease mortality for women.
authors.affiliation: Center for Medical Sciences, School of Health Sciences, Ibaraki Prefectural University of Health Sciences, Ibaraki, Japan.
authors.forename: Naomi
authors.initials: N
authors.lastname: Sakurai-Komada
authors.forename: Kazuko A
authors.initials: KA
authors.lastname: Koike
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Kaku
authors.forename: Masaki
authors.initials: M
authors.lastname: Hiraki
authors.forename: Renzhe
authors.initials: R
authors.lastname: Cui
authors.forename: Tomoko
authors.initials: T
authors.lastname: Sankai
authors.forename: Shogo
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Chigusa
authors.initials: C
authors.lastname: Date
authors.forename: Akiko
authors.initials: A
authors.lastname: Tamakoshi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Iso
mesh_terms: D016022:Case-Control Studies; D002690:Chlamydia Infections / Q000150:complications / Q000208:ethnology* / Q000382:microbiology; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification*; D003327:Coronary Disease / Q000208:ethnology* / Q000209:etiology; D005260:Female; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D012307:Risk Factors