Dietary saturated fat intake and glucose metabolism impairments in nondiabetic, nonobese patients with schizophrenia on clozapine or risperidone.
BACKGROUND
High dietary saturated fat (SF) intake is strongly linked to metabolic disturbances. The goal of this study was to understand the relationship between clozapine and risperidone with glucose and lipid metabolism and dietary fat intake in patients with schizophrenia.


METHODS
Thirty-one clozapine-treated patients and 15 risperidone-treated patients were assessed using a 4-day dietary record, an IV glucose tolerance test, and lipid profiles.


RESULTS
Clozapine-treated patients consumed a significantly higher percentage of SF than did risperidone-treated patients (13.7% +/- 3.4% vs 10.6% +/- 3.0 % of total energy; P = .007). Compared with the risperidone group, the clozapine group also had a significantly higher percentage of total fat in their diet (36% +/- 6.7% vs 30.9% +/- 5.7% of total energy; P = .007). Similarly, the clozapine group had a significant impairment in insulin sensitivity index (SI), glucose effectiveness (SG), and disposition index (DI) compared with the risperidone group (P < .05). Pearson correlation analysis of both groups showed that dietary SF was significantly correlated with impairment in glucose homeostasis (SG: r = -0.43; P = .004; DI: r = -0.35; P = .02).


CONCLUSIONS
Abnormal glucose homeostasis in atypical clozapine-treated patients with schizophrenia may be associated with or aggravated by high dietary SF consumption.
Henderson
David C
DC
Schizophrenia Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA USA. dchenderson@partners.org
Sharma
Bikash
B
Fan
Xiaoduo
X
Copeland
Paul M
PM
Borba
Christina P
CP
Freudenreich
Oliver
O
Cather
Corinne
C
Evins
A Eden
AE
Goff
Donald C
DC
D000328:Adult; D000704:Analysis of Variance; D014150:Antipsychotic Agents / Q000097:blood / Q000627:therapeutic use; D001786:Blood Glucose / Q000187:drug effects; D003024:Clozapine / Q000097:blood / Q000627:therapeutic use*; D003430:Cross-Sectional Studies; D015930:Diet Records; D004041:Dietary Fats / Q000008:administration & dosage* / Q000097:blood; D004435:Eating / Q000187:drug effects; D005260:Female; D005518:Food Preferences / Q000187:drug effects / Q000523:psychology; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D007333:Insulin Resistance; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D018967:Risperidone / Q000097:blood / Q000627:therapeutic use*; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy*
D014150:Antipsychotic Agents; D001786:Blood Glucose; D004041:Dietary Fats; D005947:Glucose; D003024:Clozapine; D018967:Risperidone