Early detection of Varicella-Zoster virus (VZV)-specific T-cells before seroconversion in primary varicella infection: case report.
Here we report the case of a 54-year old, immunocompetent German patient with primary varicella whose Varicella-Zoster Virus (VZV)-specific T-cell responses could be detected early in infection and before the onset of seroconversion. This case demonstrates that the detection of VZV-specific T-cells may under certain circumstances support the diagnosis of a primary varicella infection, as for example in cases of atypical or subclinical varicella or in the absence of detectable VZV DNA in plasma.
Baiker
Armin
A
Max von Pettenkofer-Institute, Ludwig-Maximilians-University, Munich, Germany. baiker@mvp.uni-muenchen.de
Haase
Rudolf
R
Eberle
Josef
J
Vizoso Pinto
Maria Guadalupe
MG
Pfrepper
Klaus-Ingmar
KI
Petrich
Andreas
A
Deml
Ludwig
L
Campe
Hartmut
H
Nitschko
Hans
H
Jaeger
Gundula
G
D000914:Antibodies, Viral / Q000097:blood*; D002644:Chickenpox / Q000175:diagnosis* / Q000276:immunology*; D004279:DNA, Viral / Q000097:blood; D005858:Germany; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors
D000914:Antibodies, Viral; D004279:DNA, Viral