Mitochondrial regulation of oxygen sensing.
Hypoxia promotes physiological processes such as energy metabolism, angiogenesis, cell proliferation, and cell viability through the transcription factor Hypoxia Inducible Factor (HIF). Hypoxia also diminishes the activity of ATP consuming processes to promote cell survival. The mechanism(s) by which hypoxia activates HIF and diminishes ATP demand are a subject of intensive research. Here we outline the model in which mitochondrial complex III regulate the activity of HIF and diminish ATP utilization processes through the increased production of ROS during hypoxia.
Chandel
Navdeep S
NS
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University, Chicago, IL, 606011, USA. nav@northwestern.edu
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004579:Electron Transport / Q000502:physiology; D000860:Hypoxia / Q000378:metabolism; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism*; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D014451:Ubiquinone / Q000378:metabolism
D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D017382:Reactive Oxygen Species; D014451:Ubiquinone; D000255:Adenosine Triphosphate; D011393:Procollagen-Proline Dioxygenase; D000254:Sodium-Potassium-Exchanging ATPase; D010100:Oxygen