A PIAS-ed view of DNA double strand break repair focuses on SUMO.
Through the action of multiple sensors, mediators, and effectors, the DNA damage response (DDR) orchestrates the repair of DNA damage to ensure maintenance of genomic integrity. Recently, in addition to phosphorylation, other post-translational modifications such as ubiquitylation and SUMOylation have emerged as important regulators of the DDR network. Two recent papers highlight the importance of SUMO modifications of proteins that execute the response to DNA damage.
Zlatanou
Anastasia
A
School of Cancer Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, West Midlands B15 2TT, UK.
Stewart
Grant S
GS
D000818:Animals; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D006801:Humans; D050828:Protein Inhibitors of Activated STAT / Q000378:metabolism*; D025842:SUMO-1 Protein / Q000378:metabolism*
D050828:Protein Inhibitors of Activated STAT; D025842:SUMO-1 Protein