The role of microRNA in rheumatoid arthritis and other autoimmune diseases.
MicroRNAs (miRNAs) represent a class of non-coding RNA molecules playing pivotal roles in cellular and developmental processes. miRNAs modulate the expression of multiple target genes at the post-transcriptional level and are predicted to affect up to one-third of all human protein-encoding genes. Recently, miRNA involvement in the adaptive and innate immune systems has been recognized. Rheumatoid arthritis serves an example of a chronic inflammatory disorder in which miRNAs modulate the inflammatory process in the joints, with the potential to serve as biomarkers for both the inflammatory process and the potential for therapeutic response. This review discusses the investigations that led to miRNA discovery, miRNA biogenesis and mode of action, and the diverse roles of miRNAs in modulating the immune and inflammatory responses. We conclude with a discussion of the implications of miRNA biology in rheumatoid arthritis and other autoimmune disorders.
Furer
Victoria
V
Division of Rheumatology, Department of Medicine, NYU School of Medicine/NYU Hospital for Joint Diseases, New York, NY 10009, USA. victoria.furer@nyumc.org
Greenberg
Jeffrey D
JD
Attur
Mukundan
M
Abramson
Steven B
SB
Pillinger
Michael H
MH
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007109:Immunity / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D035683:MicroRNAs / Q000502:physiology*
D035683:MicroRNAs