Evaluation of O-(2-[18F]-Fluoroethyl)-L-Tyrosine in the Diagnosis of Glioblastoma.
OBJECTIVE
To assess the feasibility of synthesis of O-(2-[(18)F]-fluoroethyl)-l-tyrosine (FET), a new positron emission tomographic (PET) tracer described in several studies but not yet considered standard in management of glioma, in routine practice and to determine FET uptake in a homogeneous group of patients with suspected high-grade glioma.


METHODS
Prospective nonrandomized trial.


METHODS
Twelve patients with suspicion of high-grade glioma.


RESULTS
The mean (SD) FET uptake ratio was 3.15 (0.72) for the 12 patients and 3.16 (0.75) for the 11 patients with glioblastoma.


CONCLUSIONS
The initial results are promising and indicate that FET PET is a valuable and applicable tool for the imaging of high-grade glioma.
Benouaich-Amiel
Alexandra
A
Pole NeuroSciences, CHU Toulouse Purpan, Place du Dr Baylac, 31059 Toulouse Cedex, France. benouaich-amiel.a@chu-toulouse.fr.
Lubrano
Vincent
V
Tafani
Mathieu
M
Uro-coste
Emmanuelle
E
Gantet
Pierre
P
Sol
Jean Christophe
JC
Roux
Franck
F
Bousquet
Philippe
P
Julian
Anne
A
Sabatier
Jean
J
Tremoulet
Michel
M
Cances-Lauwers
Valerie
V
Delisle
Marie Bernadette
MB
Clanet
Michel
M
Esquerré
Jean Philippe
JP
Payoux
Pierre
P
D001921:Brain / Q000000981:diagnostic imaging*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D005909:Glioblastoma / Q000000981:diagnostic imaging*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007091:Image Processing, Computer-Assisted; D049268:Positron-Emission Tomography / Q000379:methods*; D011446:Prospective Studies; D014443:Tyrosine / Q000031:analogs & derivatives*
C117289:O-(2-fluoroethyl)tyrosine; D014443:Tyrosine