title: A palmitoyl conjugate of insect pentapeptide Yamamarin arrests cell proliferation and respiration.
abstract: A palmitoyl conjugate of an insect pentapeptide that occurs in diapausing insects causes a reversible cell-cycle arrest and suppresses mitochondrial respiration. This peptide compound also causes growth arrest in murine leukemic cell line expressing human gene Bcr/Abl and a farnesoyl peptide induces embryonic diapause in Bombyx mori. These results demonstrate that the insect peptide compounds can lead to the understanding of a common pathway in developmental arrest in animals and may provide a new peptidominetic analog in the development of biopharmaceuticals and pest management.
authors.affiliation: Department of Agro-Bioscience, Faculty of Agriculture, Iwate University, Morioka 020-8550, Japan.
authors.forename: Yosinori
authors.initials: Y
authors.lastname: Sato
authors.forename: Ping
authors.initials: P
authors.lastname: Yang
authors.forename: Ying
authors.initials: Y
authors.lastname: An
authors.forename: Kazushige
authors.initials: K
authors.lastname: Matsukawa
authors.forename: Kikukatsu
authors.initials: K
authors.lastname: Ito
authors.forename: Shigeo
authors.initials: S
authors.lastname: Imanishi
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Matsuda
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Uchiyama
authors.forename: Kunio
authors.initials: K
authors.lastname: Imai
authors.forename: Shigeki
authors.initials: S
authors.lastname: Ito
authors.forename: Yoji
authors.initials: Y
authors.lastname: Ishida
authors.forename: Koichi
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D012831:Bombyx; D002453:Cell Cycle / Q000187:drug effects; D002460:Cell Line; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D019069:Cell Respiration / Q000187:drug effects*; D002478:Cells, Cultured; D004330:Drosophila; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics / Q000378:metabolism; D019476:Insect Proteins / Q000737:chemistry*; D051379:Mice; D008858:Microscopy, Phase-Contrast; D015394:Molecular Structure; D009036:Moths; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats
chemical_list: D019476:Insect Proteins; D009842:Oligopeptides; D016044:Fusion Proteins, bcr-abl