[Immune status parameters in patients with allergic airway diseases with bacterial sensitization].
In-depth analysis was made to study immunological parameters in 188 patients with allergic airway diseases (AAD) and bacterial sensitization and in 40 healthy individuals. No substantial changes were found in the count of CD3+, CD4+, CD20+, and CD8+ cells. However, it was ascertained that the patients with AAD showed a significant reduction in the peripheral blood levels of natural killer and CD95+ cells, at the same time there was an increase in CD25+-activated lymphocytes and in the absolute count of CD8+ cells and total IgE. As compared with the healthy individuals, the patients with ADD had elevated interleukin (IL)-1 and IL-4 and decreased interferon-gamma in cytokine immunoregulation. Thus, the study conducted leads one to believe that AAD with bacterial sensitization is an immunopathological process with a predominance of a Th2-dependent immune response.
Baranova
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NI
Kostina
E M
EM
D000293:Adolescent; D000328:Adult; D001424:Bacterial Infections / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000097:blood; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D056724:Immunity, Humoral; D007073:Immunoglobulin E / Q000097:blood; D053645:Interleukin-2 Receptor alpha Subunit / Q000097:blood; D008875:Middle Aged; D012140:Respiratory Tract Diseases / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology; D055815:Young Adult; D019014:fas Receptor / Q000097:blood
D016207:Cytokines; D053645:Interleukin-2 Receptor alpha Subunit; D019014:fas Receptor; D007073:Immunoglobulin E