Seminal plasma HIV levels in men with asymptomatic sexually transmitted infections.
The effect of asymptomatic sexually transmitted urethral infections on human immunodeficiency virus (HIV) RNA viral load in semen is poorly defined. We studied five such patients. Those on antiretrovirals (n = 2) had lower seminal plasma viral loads (SPVL) (2.11 and 1.98 log(10) copies/mL) than those not on antiretrovirals (n = 3) (2.27-3.78 log(10) copies/mL). One patient who was not taking antiretrovirals had a 94% decline in SPVL after treatment of asymptomatic Chlamydia trachomatis urethritis, suggesting that asymptomatic infection may be a co-factor for HIV transmission.
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Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center and the David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Grieg@LABioMed.org
Butler
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Smith
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Daar
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D044966:Anti-Retroviral Agents / Q000627:therapeutic use; D002353:Carrier State; D002690:Chlamydia Infections / Q000150:complications*; D002692:Chlamydia trachomatis; D018562:Disease Transmission, Infectious; D004359:Drug Therapy, Combination; D006069:Gonorrhea / Q000150:complications*; D006678:HIV / Q000235:genetics / Q000302:isolation & purification*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000635:transmission / Q000821:virology*; D006801:Humans; D008297:Male; D009344:Neisseria gonorrhoeae; D012367:RNA, Viral / Q000302:isolation & purification; D012661:Semen / Q000821:virology*; D019562:Viral Load
D044966:Anti-Retroviral Agents; D012367:RNA, Viral