Sonographic quantification of endometrial changes after abortion with computer-assisted image analysis.
OBJECTIVE
To examine the diagnostic feasibility of sonographic gray scale histograms to assess changes in the endometrium following abortion induced by mifepristone and misoprostol.


METHODS
Retrospective study.


METHODS
Taipei Medical University-Wan Fang academic medical center.


METHODS
A total of 109 patients who matched eligibility criteria were divided into three groups: (a) complete abortion, (b) normal menstrual cycles, and (c) incomplete abortion.


METHODS
Ultrasonographic examination of the uterus with fixed settings on each patient and sonographic gray scale histograms with image analysis software, using multivariate analysis by the partial least square model.


METHODS
Thickness, brightness, area and distribution of pixels of the endometrium and its contents.


RESULTS
The groups could be discriminated (p < 0.01, Kruskal-Wallis test) using the analyzed gray scale histograms. The classification between complete and incomplete abortion reached 97% sensitivity and 100% specificity.


CONCLUSIONS
Partial least square analysis of gray scale histograms of the endometrium in ultrasonographic images is useful in assessing endometrial changes.
Chou
Szu-Yuan
SY
Taipei Medical University-Wan Fang Medical Center, Department of Obstetrics and Gynecology, Taipei, Taiwan.
Chen
Chih-Yen
CY
Hsu
Ming-I
MI
Chow
Pui-Ki
PK
Hsu
Chun-Sen
CS
Chiang
Huihua Kenny
HK
D000020:Abortifacient Agents, Nonsteroidal / Q000627:therapeutic use; D000021:Abortifacient Agents, Steroidal / Q000627:therapeutic use; D000028:Abortion, Induced; D000328:Adult; D004717:Endometrium / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D016018:Least-Squares Analysis; D015735:Mifepristone / Q000627:therapeutic use; D016595:Misoprostol / Q000627:therapeutic use; D011247:Pregnancy; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014463:Ultrasonography
D000020:Abortifacient Agents, Nonsteroidal; D000021:Abortifacient Agents, Steroidal; D016595:Misoprostol; D015735:Mifepristone