Recent insights into the building and cycling of synaptic vesicles.
The synaptic vesicle is currently the most well-characterized cellular organelle. During neurotransmitter release it undergoes multiple cycles of exo- and endocytosis. Despite this the vesicle manages to retain its protein and lipid composition. How does this happen? Here we provide a brief overview of the molecular architecture of the synaptic vesicle, and discuss recent studies investigating single vesicle behavior and the mechanisms controlling the vesicle's molecular contents.
Shupliakov
Oleg
O
Department of Neuroscience, DBRM, Karolinska Institutet, S-171 77 Stockholm, Sweden. oleg.shupliakov@ki.se
Brodin
Lennart
L
D000818:Animals; D004705:Endocytosis; D005089:Exocytosis; D006801:Humans; D018377:Neurotransmitter Agents / Q000378:metabolism*; D013572:Synaptic Vesicles / Q000378:metabolism*
D018377:Neurotransmitter Agents