title: Amifostine ameliorates recognition memory defect in acute radiation syndrome caused by relatively low-dose of gamma radiation.
abstract: This study examined whether amifostine (WR-2721) could attenuate memory impairment and suppress hippocampal neurogenesis in adult mice with the relatively low-dose exposure of acute radiation syndrome (ARS). These were assessed using object recognition memory test, the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay, and immunohistochemical markers of neurogenesis [Ki-67 and doublecortin (DCX)]. Amifostine treatment (214 mg/kg, i.p.) prior to irradiation significantly attenuated the recognition memory defect in ARS, and markedly blocked the apoptotic death and decrease of Ki-67- and DCX-positive cells in ARS. Therefore, amifostine may attenuate recognition memory defect in a relatively low-dose exposure of ARS in adult mice, possibly by inhibiting a detrimental effect of irradiation on hippocampal neurogenesis.
authors.affiliation: Korea Institute of Radiological and Medical Science, Seoul, Korea.
authors.forename: Hae-June
authors.initials: HJ
authors.lastname: Lee
authors.forename: Joong-Sun
authors.initials: JS
authors.lastname: Kim
authors.forename: Myoung-Sub
authors.initials: MS
authors.lastname: Song
authors.forename: Heung-Sik
authors.initials: HS
authors.lastname: Seo
authors.forename: Miyoung
authors.initials: M
authors.lastname: Yang
authors.forename: Jong Choon
authors.initials: JC
authors.lastname: Kim
authors.forename: Sung-Kee
authors.initials: SK
authors.lastname: Jo
authors.forename: Taekyun
authors.initials: T
authors.lastname: Shin
authors.forename: Changjong
authors.initials: C
authors.lastname: Moon
authors.forename: Sung-Ho
authors.initials: SH
authors.lastname: Kim
mesh_terms: D054508:Acute Radiation Syndrome / Q000188:drug therapy / Q000276:immunology* / Q000523:psychology; D004999:Amifostine / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D017209:Apoptosis / Q000276:immunology; D000089662:Doublecortin Protein; D005720:Gamma Rays / Q000009:adverse effects*; D006624:Hippocampus / Q000276:immunology; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D008297:Male; D008568:Memory / Q000528:radiation effects*; D051379:Mice; D008813:Mice, Inbred ICR; D055495:Neurogenesis / Q000276:immunology; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: C000714847:Dcx protein, mouse; D000089662:Doublecortin Protein; D011837:Radiation-Protective Agents; D004999:Amifostine