title: Complete regression of a previously untreated melanoma brain metastasis with ipilimumab.
abstract: Anecdotal cases of partial or complete responses have been reported after ipilimumab therapy for stage IV melanoma with brain metastasis treated earlier by surgery or radiosurgery. We report the first case of ipilimumab monotherapy resulting in durable complete remission of untreated, progressive brain metastases in a patient with stage IV melanoma. This case and earlier reports provide support for the further evaluation of ipilimumab in melanoma patients with brain metastasis.
authors.affiliation: Department of Dermatology, Hôpital Saint Louis Assistance Publique-Hôpitaux Paris, University of Paris 7, INSERM U976, Paris, France.
authors.forename: Noël E C
authors.initials: NE
authors.lastname: Schartz
authors.forename: Cécile
authors.initials: C
authors.lastname: Farges
authors.forename: Isabelle
authors.initials: I
authors.lastname: Madelaine
authors.forename: Heriberto
authors.initials: H
authors.lastname: Bruzzoni
authors.forename: Fabien
authors.initials: F
authors.lastname: Calvo
authors.forename: Axel
authors.initials: A
authors.lastname: Hoos
authors.forename: Céleste
authors.initials: C
authors.lastname: Lebbé
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D006801:Humans; D000074324:Ipilimumab; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology*; D009362:Neoplasm Metastasis; D012044:Regression Analysis; D012074:Remission Induction; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D000074324:Ipilimumab