Transcriptional regulation of bone and joint remodeling by NFAT.
Osteoporosis and arthritis are highly prevalent diseases and a significant cause of morbidity and mortality worldwide. These diseases result from aberrant tissue remodeling leading to weak, fracture-prone bones or painful, dysfunctional joints. The nuclear factor of activated T cells (NFAT) transcription factor family controls diverse biologic processes in vertebrates. Here, we review the scientific evidence that links NFAT-regulated gene transcription to bone and joint pathology. A particular emphasis is placed on the role of NFATs in bone resorption and formation by osteoclasts and osteoblasts, respectively. In addition, emerging data that connect NFATs with cartilage biology, angiogenesis, nociception, and neurogenic inflammation are explored. The goal of this article is to highlight the importance of tissue remodeling in musculoskeletal disease and situate NFAT-driven cellular responses within this context to inspire future research endeavors.
Sitara
Despina
D
Department of Infectious Diseases and Immunology, Harvard School of Public Health, Boston, MA 02115, USA.
Aliprantis
Antonios O
AO
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D016723:Bone Remodeling / Q000235:genetics*; D019703:Calcineurin / Q000378:metabolism; D020219:Chondrogenesis / Q000235:genetics*; D006801:Humans; D007596:Joints / Q000378:metabolism* / Q000473:pathology; D050778:NFATC Transcription Factors / Q000235:genetics / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D010003:Osteoarthritis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D010006:Osteoblasts / Q000378:metabolism; D010010:Osteoclasts / Q000378:metabolism; D010024:Osteoporosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D010146:Pain / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D050778:NFATC Transcription Factors; D019703:Calcineurin