Concomitant administration of recombinant PsaA and PCV7 reduces Streptococcus pneumoniae serotype 19A colonization in a murine model.
A murine colonization model was used to determine the effect of co-administering 7-valent polysaccharide-protein conjugate vaccine and pneumococcal surface adhesin A. Mice were challenged intranasally with either PCV7 serotypes, 4 or 14, or a non-PCV7 serotype, 19A. Post-challenge samples were evaluated for IgG antibody levels, opsonophagocytic activity, and nasopharyngeal colonization. No interference was observed between immune responses from the concomitant and individual immunizations. Concomitant immunizations reduced carriage for tested serotypes; largest reduction was observed for 19A. From these mouse studies, co-administering pneumococcal antigens appear to expand coverage and reduce colonization against a non-PCV7 serotype without inhibiting immunogenicity to other serotypes.
Whaley
Melissa J
MJ
Division of Bacterial Diseases, Center of Disease Control and Prevention, 1600 Clifton Rd NE, MS G-05, Atlanta, GA 30333, USA. mwhaley@cdc.gov
Sampson
Jacquelyn S
JS
Johnson
Scott E
SE
Rajam
Gowrisankar
G
Stinson-Parks
Annie
A
Holder
Patricia
P
Mauro
Erica
E
Romero-Steiner
Sandra
S
Carlone
George M
GM
Ades
Edwin W
EW
D018829:Adhesins, Bacterial / Q000008:administration & dosage / Q000276:immunology*; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D002353:Carrier State / Q000517:prevention & control*; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D008074:Lipoproteins / Q000008:administration & dosage / Q000276:immunology*; D051379:Mice; D009895:Opsonin Proteins / Q000097:blood; D010587:Phagocytosis; D022242:Pneumococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D013290:Streptococcal Infections / Q000517:prevention & control*; D013296:Streptococcus pneumoniae / Q000276:immunology*; D017778:Vaccines, Combined / Q000008:administration & dosage / Q000276:immunology
D018829:Adhesins, Bacterial; D000907:Antibodies, Bacterial; D000069443:Heptavalent Pneumococcal Conjugate Vaccine; D008074:Lipoproteins; D009895:Opsonin Proteins; D022242:Pneumococcal Vaccines; C085000:PsaA protein, Streptococcus; D017778:Vaccines, Combined