Increased synaptic dopamine function in associative regions of the striatum in schizophrenia.
BACKGROUND
A long-standing version of the dopamine hypothesis of schizophrenia postulates that hyperactivity of dopaminergic transmission at D(2) receptors in the limbic striatum is associated with the illness and that blockade of mesolimbic D(2) receptors is responsible for the antipsychotic action of D(2) receptor antagonists.


OBJECTIVE
To localize dopaminergic hyperactivity within the striatum in schizophrenia.


METHODS
Case-control study.


METHODS
Inpatient research unit.


METHODS
Eighteen untreated patients with schizophrenia and 18 healthy control subjects matched for age, sex, ethnicity, parental socioeconomic status, cigarette smoking, and weight.


METHODS
Percentage change in dopamine D(2) receptor availability in striatal subregions within each subject measured by positron emission tomography with carbon 11-labeled raclopride before and during pharmacologically induced dopamine depletion.


RESULTS
In the associative striatum, acute dopamine depletion resulted in a larger increase in D(2) receptor availability in patients with schizophrenia (mean [SD], 15% [7%]) than in control subjects (10% [7%], P = .045), suggesting higher synaptic dopamine concentration. Within the associative striatum, this effect was most pronounced in the precommissural dorsal caudate (15% [8%] in patients vs 9% [8%] in controls, P = .03). No between-group differences were observed in the limbic and sensorimotor striatum.


CONCLUSIONS
These findings suggest that schizophrenia is associated with elevated dopamine function in associative regions of the striatum. Because the precommissural dorsal caudate processes information from the dorsolateral prefrontal cortex, this observation also suggests that elevated subcortical dopamine function might adversely affect performance of the dorsolateral prefrontal cortex in schizophrenia. On the other hand, the absence of a group difference in the limbic striatum brings into question the therapeutic relevance of the mesolimbic selectivity of second-generation antipsychotic drugs.
Kegeles
Lawrence S
LS
Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA. lsk5@columbia.edu
Abi-Dargham
Anissa
A
Frankle
W Gordon
WG
Gil
Roberto
R
Cooper
Thomas B
TB
Slifstein
Mark
M
Hwang
Dah-Ren
DR
Huang
Yiyun
Y
Haber
Suzanne N
SN
Laruelle
Marc
M
D000328:Adult; D001931:Brain Mapping; D002250:Carbon Radioisotopes; D016022:Case-Control Studies; D002421:Caudate Nucleus / Q000378:metabolism / Q000502:physiology; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D049268:Positron-Emission Tomography; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000503:physiopathology; D011699:Putamen / Q000378:metabolism / Q000502:physiology; D020891:Raclopride; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology*; D013569:Synapses / Q000187:drug effects / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D019805:alpha-Methyltyrosine / Q000494:pharmacology
D002250:Carbon Radioisotopes; D017448:Receptors, Dopamine D2; D020891:Raclopride; D019805:alpha-Methyltyrosine; D004298:Dopamine