Gastrin-releasing peptide receptor content in human glioma and normal brain.
The gastrin-releasing peptide receptor (GRPR) has been put forward as a therapeutic target in brain tumors. Here we evaluated GRPR presence in glioma specimens from patients as well as in normal human brain samples. Sections of paraffin-embedded brain tumors and non-neoplastic control brain tissue were analyzed with immunohistochemistry for GRPR content. Digital image analysis revealed that 100% of glioma samples were GRPR-positive, with a mean index of 4972 pixels. In normal brain tissue, GRPR was detected in neurons, but not glial cells. This study is the first to confirm the presence of GRPR in human glioma specimens and normal human neurons.
Flores
Debora Gazzana
DG
Cancer Research Laboratory, University Hospital Research Center (CPE-HCPA), Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, 2350, 90035-003 Porto Alegre, RS, Brazil.
Meurer
Luise
L
Uberti
Augusto Frantz
AF
Macedo
Bruno R
BR
Lenz
Guido
G
Brunetto
Algemir Lunardi
AL
Schwartsmann
Gilberto
G
Roesler
Rafael
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018004:Receptors, Bombesin / Q000378:metabolism*; D055815:Young Adult
D018004:Receptors, Bombesin