title: Multistage inversion algorithm for biological tissue imaging.
abstract: A new inversion method for diffuse optical tomography is proposed. This is a multistage algorithm, that uses a signal subspace-based method to simplify the inverse problem and proposes a guided iterative inversion process to improve the imaging. First, subspace-based analysis is used to determine the voxels that definitely belong to the background and exclude them from further consideration. Then, the pseudo-inverse technique is applied for reconstruction. In the final stage, the reconstruction is improved iteratively by finding and excluding more voxels belonging to background. The method reduces the ill-posedness of the image reconstruction problem iteratively such that good imaging results are obtained for multiple heterogeneities having complicated geometries even in the presence of 3% additive white noise.
authors.affiliation: National University of Singapore, Department of Electrical and Computer Engineering, Singapore.
authors.forename: Krishna
authors.initials: K
authors.lastname: Agarwal
authors.forename: Ling
authors.initials: L
authors.lastname: Chen
authors.forename: Nanguang
authors.initials: N
authors.lastname: Chen
authors.forename: Xudong
authors.initials: X
authors.lastname: Chen
mesh_terms: D000465:Algorithms; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D016018:Least-Squares Analysis; D008962:Models, Theoretical; D041622:Tomography, Optical / Q000379:methods*