Palladium-catalyzed aerobic oxidative cross-coupling reactions of terminal alkynes with alkylzinc reagents.
With air as the oxidant, terminal alkynes can be directly cross-coupled with alkylzinc reagents in the presence of a Pd catalyst at room temperature. CO was found to be critical in gaining high chemical yields and selectivities. A wide range of alkynes and alkylzinc reagents were tested, and good to excellent yields were obtained.
Chen
Mao
M
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, PR China.
Zheng
Xiaolong
X
Li
Wenqing
W
He
Jun
J
Lei
Aiwen
A