title: The first complete papillomavirus genome characterized from a marsupial host: a novel isolate from Bettongia penicillata.
abstract: The first fully sequenced papillomavirus (PV) of marsupials, tentatively named Bettongia penicillata papillomavirus type 1 (BpPV1), was detected in papillomas from a woylie (Bettongia penicillata ogilbyi). The circular, double-stranded DNA genome contains 7,737 bp and encodes 7 open reading frames (ORFs), E6, E7, E1, E2, E4, L2, and L1, in typical PV conformation. BpPV1 is a close-to-root PV with L1 and L2 ORFs most similar to European hedgehog PV and bandicoot papillomatosis carcinomatosis virus types 1 and 2 (BPCV1 and -2). It appears that the BPCVs arose by recombination between an ancient PV and an ancient polyomavirus more than 10 million years ago.
authors.affiliation: School of Veterinary and Biomedical Sciences, Murdoch University, South Street, Murdoch, Western Australia 6150, Australia. m.bennett@murdoch.edu.au
authors.forename: Mark D
authors.initials: MD
authors.lastname: Bennett
authors.forename: Andrea
authors.initials: A
authors.lastname: Reiss
authors.forename: Hans
authors.initials: H
authors.lastname: Stevens
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Heylen
authors.forename: Marc
authors.initials: M
authors.lastname: Van Ranst
authors.forename: Adrian
authors.initials: A
authors.lastname: Wayne
authors.forename: Michael
authors.initials: M
authors.lastname: Slaven
authors.forename: Jennifer N
authors.initials: JN
authors.lastname: Mills
authors.forename: Kristin S
authors.initials: KS
authors.lastname: Warren
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: O'Hara
authors.forename: Philip K
authors.initials: PK
authors.lastname: Nicholls
mesh_terms: D000818:Animals; D001483:Base Sequence; D016000:Cluster Analysis; D004247:DNA / Q000235:genetics; D004270:DNA, Circular / Q000235:genetics; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics*; D016679:Genome, Viral; D008297:Male; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010212:Papilloma / Q000662:veterinary* / Q000821:virology; D010802:Phylogeny; D011120:Polyomavirus / Q000235:genetics* / Q000302:isolation & purification; D027601:Polyomavirus Infections / Q000662:veterinary* / Q000821:virology; D048328:Potoroidae / Q000821:virology*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014412:Tumor Virus Infections / Q000662:veterinary* / Q000821:virology; D014764:Viral Proteins / Q000235:genetics
chemical_list: D004270:DNA, Circular; D004279:DNA, Viral; D014764:Viral Proteins; D004247:DNA