title: Quinine-resistant malaria in traveler returning from Senegal, 2007.
abstract: We describe clinical and parasitologic features of in vivo and in vitro Plasmodium falciparum resistance to quinine in a nonimmune traveler who returned to France from Senegal in 2007 with severe imported malaria. Clinical quinine failure was associated with a 50% inhibitory concentration of 829 nmol/L. Increased vigilance is required during treatment follow-up.
authors.affiliation: Institut de Medecine Tropicale du Service de Sante des Armees, Marseille, France.
authors.forename: Bruno
authors.initials: B
authors.lastname: Pradines
authors.forename: Thierry
authors.initials: T
authors.lastname: Pistone
authors.forename: Khaled
authors.initials: K
authors.lastname: Ezzedine
authors.forename: Sebastien
authors.initials: S
authors.lastname: Briolant
authors.forename: Lionel
authors.initials: L
authors.lastname: Bertaux
authors.forename: Marie Catherine
authors.initials: MC
authors.lastname: Receveur
authors.forename: Daniel
authors.initials: D
authors.lastname: Parzy
authors.forename: Pascal
authors.initials: P
authors.lastname: Millet
authors.forename: Christophe
authors.initials: C
authors.lastname: Rogier
authors.forename: Denis
authors.initials: D
authors.lastname: Malvy
mesh_terms: D000293:Adolescent; D000962:Antimalarials / Q000008:administration & dosage / Q000494:pharmacology*; D004351:Drug Resistance; D005602:France; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology; D008297:Male; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D011803:Quinine / Q000008:administration & dosage / Q000494:pharmacology*; D012675:Senegal; D014195:Travel
chemical_list: D000962:Antimalarials; D011803:Quinine