title: Intercontinental spread from Israel to Colombia of a KPC-3-producing Klebsiella pneumoniae strain.
abstract: In 2008, an increase in the prevalence of carbapenem-resistant Klebsiella pneumoniae was noted in a 286-bed tertiary case hospital in Colombia, where 84 patients (32 infected and 52 colonized) had positive cultures. The identified index patient came from Israel for a liver transplantation. High level carbapenem resistance was observed. Polymyxin B and tigecycline were the only two antibiotics that remained active. PCR-restriction fragment length polymorphism analysis and sequencing revealed blaKPC-3 in the major clone, which was indistinguishable from the K. pneumoniae carbapenemase-3-producing clone described previously in Israel. This exemplifies the threat posed by the global spread of K. pneumoniae carbapenemase-producing pathogens.
authors.affiliation: Hospital Pablo Tobón Uribe, Medellín, Colombia.
authors.forename: J A
authors.initials: JA
authors.lastname: Lopez
authors.forename: A
authors.initials: A
authors.lastname: Correa
authors.forename: S
authors.initials: S
authors.lastname: Navon-Venezia
authors.forename: A L
authors.initials: AL
authors.lastname: Correa
authors.forename: J A
authors.initials: JA
authors.lastname: Torres
authors.forename: D F
authors.initials: DF
authors.lastname: Briceño
authors.forename: M C
authors.initials: MC
authors.lastname: Montealegre
authors.forename: J P
authors.initials: JP
authors.lastname: Quinn
authors.forename: Y
authors.initials: Y
authors.lastname: Carmeli
authors.forename: M V
authors.initials: MV
authors.lastname: Villegas
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001426:Bacterial Proteins / Q000378:metabolism*; D003105:Colombia; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality / Q000635:transmission*; D006801:Humans; D007557:Israel; D007710:Klebsiella Infections / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality / Q000635:transmission*; D007711:Klebsiella pneumoniae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D058889:Molecular Typing; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D001618:beta-Lactamases; C495220:beta-lactamase KPC-3, Klebsiella pneumoniae