Design and efficient synthesis of a new scaffold based on unsymmetrical protoporphyrin IX derivatives for use in SPPS.
Fmoc-protected amine derivatives of Protoporphyrin IX were synthesized by two original methods using solid-phase chemistry. The new compounds represent unsymmetrical scaffolds suitable for the generation of a large range of peptidic porphyrin derivatives through SPPS strategy.
Bakleh
M-E
ME
Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069 Faculté des Sciences et Techniques, 123 Avenue Albert Thomas, 87060 Limoges, France.
Sol
V
V
Granet
R
R
Déléris
G
G
Estieu-Gionnet
K
K
Krausz
P
P
D004951:Esterification; D019906:Nuclear Magnetic Resonance, Biomolecular; D010455:Peptides / Q000737:chemistry*; D011524:Protoporphyrins / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013056:Spectrophotometry, Ultraviolet
D010455:Peptides; D011524:Protoporphyrins; C028025:protoporphyrin IX