title: Palladium catalyzed synthesis of 2-trifluoromethylquinolines through a domino Sonogashira-alkyne carbocyclization process.
abstract: A new, rapid and high-yielding method to prepare 3,4-disubstituted 2-trifluoromethylquinolines by a palladium catalyzed tandem Sonogashira-alkyne carbocyclization of beta-trifluoromethyl beta-enaminoketones with arynes is described. Moderate to excellent yields have been achieved under mild conditions. This reaction can also be expanded to the non-fluorine containing substrates. The reaction mechanism is also discussed.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Zixian
authors.initials: Z
authors.lastname: Chen
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Zhu
authors.forename: Haibo
authors.initials: H
authors.lastname: Xie
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.forename: Yongming
authors.initials: Y
authors.lastname: Wu
authors.forename: Yuefa
authors.initials: Y
authors.lastname: Gong
mesh_terms: D002384:Catalysis; D003500:Cyclization; D010165:Palladium / Q000737:chemistry*; D011804:Quinolines / Q000138:chemical synthesis*
chemical_list: D011804:Quinolines; D010165:Palladium