title: [Stability of some medicinal solutions with captopril].
abstract: The aim of the study was to investigate the stability of some oral liquid formulations containing 1 mg/ml captopril.
  
  
  METHODS
  The oral solutions were prepared using captopril substance, keeping the formulation as simple as possible to avoid potentially undesirable excipients. Samples were stored for 39 days below 8 degrees C and at 22 +/- 3 degrees C and analysed for physical, chemical and microbiological stability.
  
  
  RESULTS
  The formulations with ascorbic acid are stable for seven days either at 8 and 22 degrees C and could be prepared in hospital pharmacy as a more safely alternative to children terapy with tablets powders.
authors.affiliation: Facultatea de Farmacie, Disciplina de Analiza Medicamentului, Universitatea de Medicină si Farmacie din Târgu-Mureş.
authors.forename: Silvia
authors.initials: S
authors.lastname: Imre
authors.forename: Szende
authors.initials: S
authors.lastname: Vancea
authors.forename: Daniela Lucia
authors.initials: DL
authors.lastname: Muntean
authors.forename: Emese
authors.initials: E
authors.lastname: Sipos
authors.forename: Adela
authors.initials: A
authors.lastname: Cociş
authors.forename: Veronica
authors.initials: V
authors.lastname: Avrigeanu
authors.forename: Eleonora
authors.initials: E
authors.lastname: Mircia
mesh_terms: D000959:Antihypertensive Agents / Q000493:pharmacokinetics*; D002216:Captopril / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D004356:Drug Storage; D006801:Humans; D019999:Pharmaceutical Solutions; D013696:Temperature
chemical_list: D000959:Antihypertensive Agents; D019999:Pharmaceutical Solutions; D002216:Captopril