title: Biogenesis of bacterial inner-membrane proteins.
abstract: All cells must traffic proteins into and across their membranes. In bacteria, several pathways have evolved to enable protein transfer across the inner membrane, the periplasm, and the outer membrane. The major route of protein translocation in and across the cytoplasmic membrane is the general secretion pathway (Sec-pathway). The biogenesis of membrane proteins not only requires protein translocation but also coordinated targeting to the membrane beforehand and folding and assembly into their protein complexes afterwards to function properly in the cell. All these processes are responsible for the biogenesis of membrane proteins that mediate essential functions of the cell such as selective transport, energy conversion, cell division, extracellular signal sensing, and motility. This review will highlight the most recent developments on the structure and function of bacterial membrane proteins, focusing on the journey that integral membrane proteins take to find their final destination in the inner membrane.
authors.affiliation: Institute of Microbiology, University of Hohenheim, Stuttgart, Germany.
authors.forename: Sandra J
authors.initials: SJ
authors.lastname: Facey
authors.forename: Andreas
authors.initials: A
authors.lastname: Kuhn
mesh_terms: D025181:ATP Synthetase Complexes / Q000378:metabolism; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D020346:Aquaporins / Q000378:metabolism; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D004579:Electron Transport; D005407:Flagella / Q000378:metabolism; D006090:Gram-Negative Bacteria / Q000378:metabolism*; D008565:Membrane Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism; D020409:Molecular Motor Proteins / Q000378:metabolism; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System / Q000378:metabolism; D045322:Photosynthetic Reaction Center Complex Proteins / Q000378:metabolism; D017510:Protein Folding; D021381:Protein Transport; D015398:Signal Transduction
chemical_list: D018528:ATP-Binding Cassette Transporters; D020346:Aquaporins; D001426:Bacterial Proteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D020409:Molecular Motor Proteins; D045322:Photosynthetic Reaction Center Complex Proteins; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System; D025181:ATP Synthetase Complexes