title: Resection of the nerves bundle from the sphenopalatine ganglia tend to increase the infarction volume following middle cerebral artery occlusion.
abstract: Blocking or impairment of the sphenopalatine ganglia (SPG) is an effective therapy of cluster headache and other pain syndromes. Contrarily, unilateral SPG-stimulation reduces infarction size in the rat permanent suture model. Well, what are the effects of the SPG damage on the following brain ischemia? This study was aimed to investigate the effects of resection of the nerves bundle from the SPG of rat on the brain lesions following middle cerebral artery occlusion (MCAO), and evaluated the roles of the nitric oxygen synthase (NOS) immunoreactive perivascular nerves of cerebral arteries in MCAO. We found that 7 days after bilateral resections of the nerves bundle from the SPG, the NOS activity perivascular nerves in the middle cerebral arteries disappeared, and the infarction volume and the TUNEL positive cells increased significantly after 24 h MCAO, which implicated that the NOS contained nerves from the SPG maybe have an important role in the MCAO.
authors.affiliation: Department of Anesthesiology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, 1630 Dong Fang Road, 200127, Shanghai, China.
authors.forename: Su
authors.initials: S
authors.lastname: Diansan
authors.forename: Zhang
authors.initials: Z
authors.lastname: Shifen
authors.forename: Gu
authors.initials: G
authors.lastname: Zhen
authors.forename: Wang
authors.initials: W
authors.lastname: Heming
authors.forename: Wang
authors.initials: W
authors.lastname: Xiangrui
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000473:pathology; D002452:Cell Count; D005726:Ganglia, Parasympathetic / Q000201:enzymology / Q000601:surgery*; D007150:Immunohistochemistry; D020287:In Situ Nick-End Labeling; D020244:Infarction, Middle Cerebral Artery / Q000201:enzymology / Q000473:pathology*; D008026:Ligation; D020768:Middle Cerebral Artery / Q000201:enzymology / Q000294:innervation* / Q000473:pathology*; D009252:NADPH Dehydrogenase / Q000378:metabolism; D009412:Nerve Fibers / Q000201:enzymology; D019001:Nitric Oxide Synthase / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019001:Nitric Oxide Synthase; D009252:NADPH Dehydrogenase