ApoE mimetic peptide reduces plasma lipid hydroperoxide content with a concomitant increase in HDL paraoxonase activity.
ApoE mimetic peptide possesses the putative receptor binding domain 141-150 (LRKLRKRLLR) of apoE covalently linked to the class A amphipathic helical peptide 18A. It dramatically reduces plasma cholesterol in dyslipidemic mouse and rabbit models. Recycling of apoE mimetic peptide increases the duration of preβ-HDL formation leading to extended anti-inflammatory and atheroprotective properties.
Datta
Geeta
G
Departments of Medicine, Biochemistry and Molecular Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA. gdatta@uab.edu
Chaddha
Manjula
M
Handattu
Shaila P
SP
Palgunachari
Mayakonda N
MN
Nayyar
Gaurav
G
Garber
David W
DW
Gupta
Himanshu
H
White
C Roger
CR
Anantharamaiah
G M
GM
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001057:Apolipoproteins E / Q000737:chemistry*; D043303:Aryldialkylphosphatase / Q000737:chemistry*; D050197:Atherosclerosis / Q000517:prevention & control; D002460:Cell Line; D006801:Humans; D006861:Hydrogen Peroxide / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D008075:Lipoproteins, HDL / Q000737:chemistry*; D051379:Mice; D010455:Peptides / Q000737:chemistry; D011817:Rabbits; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D001057:Apolipoproteins E; D008055:Lipids; D008075:Lipoproteins, HDL; D010455:Peptides; D006861:Hydrogen Peroxide; D043303:Aryldialkylphosphatase