Genomic instability and rapid clinical course in adult T-cell lymphoma/leukemia patient.
Adult T-cell leukemia/lymphoma is a distinct clinical entity characterized by a clonal proliferation of malignant T-lymphocytes. The etiologic agent of the disease is a Human T-cell lymphotropic virus type I. It occurs almost exclusively in areas where the virus is endemic; however the disease develops only in the minority of patients who are virus carriers. Karyotyping findings and their correlation with clinical features are still limited in T-cell malignancies, complicated by clinical heterogeneity and a plethora of secondary abnormalities. This study describes detailed chromosomal and fluorescence in situ hybridization results observed in a patient with adult T-cell leukemia/lymphoma and correlates them with clinical characteristics.
Zámecníkova
Adriana
A
Department of Hematology, Kuwait Cancer Control Center, Shuwalkh, Kuwait. annaadria@yahoo.com
Al Bahar
Soad
S
Elshinnawy
Samah E
SE
D000328:Adult; D005260:Female; D042822:Genomic Instability; D015490:HTLV-I Infections / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D015368:Human T-lymphotropic virus 1; D006801:Humans; D007621:Karyotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D013601:T-Lymphocytes