Recent advances in alveolar biology: some new looks at the alveolar interface.
This article examines the manner in which some new methodologies and novel concepts have contributed to our understanding of how pulmonary surfactant reduces alveolar surface tension. Investigations utilizing small angle X-ray diffraction, inverted interface fluorescence microscopy, time of flight-secondary ion mass spectroscopy, atomic force microscopy, two-photon fluorescence microscopy and electrospray mass spectroscopy are highlighted and a new model of ventilation-induced acute lung injury described. This contribution attempts to emphasize how these new approaches have resulted in a fuller appreciation of events presumably occurring at the alveolar interface.
Possmayer
Fred
F
University of Western Ontario, Departments of Obstetrics/Gynaecology and Biochemistry, London, Ontario, Canada. fpossmay@uwo.ca
Hall
Stephen B
SB
Haller
Thomas
T
Petersen
Nils O
NO
Zuo
Yi Y
YY
Bernardino de la Serna
Jorge
J
Postle
Anthony D
AD
Veldhuizen
Ruud A W
RA
Orgeig
Sandra
S
D055371:Acute Lung Injury / Q000503:physiopathology; D000818:Animals; D006801:Humans; D051379:Mice; D011650:Pulmonary Alveoli / Q000502:physiology*; D011663:Pulmonary Surfactants / Q000737:chemistry*; D051381:Rats; D013499:Surface Properties; D013500:Surface Tension; D055397:Ventilator-Induced Lung Injury / Q000503:physiopathology
D011663:Pulmonary Surfactants