title: Thiol-dependent DNA cleavage by aminomethylated Beaucage's reagent.
abstract: Aminomethylated Beaucage's reagent 1 was found to be more potent than 3H-1,2-benzodithiol-3-one 1,1-dioxide (Beaucage's reagent) in causing DNA cleavage. The current study demonstrated the importance of the amino functionality in enhancing DNA-cleaving activities, and such findings may facilitate development of novel sulfur-containing DNA-cleaving molecules in cancer therapy.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore, 117543, Republic of Singapore.
authors.forename: Jiahui
authors.initials: J
authors.lastname: Zheng
authors.forename: Xiaoqian
authors.initials: X
authors.lastname: Liu
authors.forename: Qing
authors.initials: Q
authors.lastname: Yuan
authors.forename: Yoon-Joo
authors.initials: YJ
authors.lastname: Shin
authors.forename: Daekyu
authors.initials: D
authors.lastname: Sun
authors.forename: Yixin
authors.initials: Y
authors.lastname: Lu
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006863:Hydrogen-Ion Concentration; D008745:Methylation; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: C414667:1,2-benzodithiol-3-one-1,1-dioxide; D013438:Sulfhydryl Compounds; D004247:DNA