PRDM9 points the zinc finger at meiotic recombination hotspots.
Meiotic recombination events are spread nonrandomly across eukaryotic genomes in 'hotspots'. Recent work shows that a unique histone methyltransferase, PRDM9, determines their distribution.
Neale
Matthew J
MJ
MRC Genome Damage and Stability Centre, University of Sussex, Brighton BN1 9RQ, UK. m.neale@sussex.ac.uk
D000818:Animals; D002843:Chromatin / Q000235:genetics; D053903:DNA Breaks, Double-Stranded; D019143:Evolution, Molecular; D018703:Founder Effect; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics*; D006801:Humans; D008540:Meiosis / Q000235:genetics*; D051379:Mice; D002679:Pan troglodytes / Q000235:genetics; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics; D016335:Zinc Fingers / Q000235:genetics*
D002843:Chromatin; D000076983:Histone Methyltransferases; D011495:Histone-Lysine N-Methyltransferase; C544431:PRDM9 protein, human