[The antistress effect of the saponinic summ extracted from roots of Aralia mandshurica cultivated in Moldavia].
The effects of the saponinic summ extracted from roots of Aralia mandshurica have been studied in experimentally animals exposed to stress.


METHODS
The experiment was carried out on 4 groups of animals divided into 24 lots of 12 white rats each with experimentally induced chronic inflammation or/and exposed to stress induced by exposure to continuous dark or light. The drugs (Levamisole (LVM) (10mg/kg bw/day), Indometacin (IND) (1.42 mg/kg bw/day), Extract of the roots of Aralia mandshurica (SAR) (26.25 mg/kg bw/day) and saline solution (0.5 mL/100 g bw/day) were administered orally for 14 days, in unique daily dose. Blood samples were taken from rats' retroorbital plexus before the beginning of the treatment protocol (M0) and at the finish of the treatment (M1) in order to assay differential cell count, peripheral neutrophils activity (NBT test) and serum complement activity.


RESULTS
The SAR extracts exert influence on immunity defence cellular's components without influence on humoral efects, no matter of experimentally conditions. They determined decreasing of the percentage of the neutrophils in peripheral blood (at the lower levels than Indometacin (IND).


CONCLUSIONS
The experimental results demonstrated immunomodulatory effect of this saponine extract.
Lupuşoru
Cătălina Elena
CE
Disciplina de Farmacologie-Algeziologie, Facultatea de Medicină, Universitatea de Medicina si Farmacie Gr.T. Popa Iaşi.
Zagnat
M
M
Ghiciuc
Cristina Mihaela
CM
Lupuşoru
R
R
Stănescu
Ursula
U
Grigorescu
Em
E
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology / Q000627:therapeutic use*; D027983:Aralia; D004195:Disease Models, Animal; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar; D012383:Romania; D013312:Stress, Physiological / Q000187:drug effects*
D014151:Anti-Anxiety Agents; D010936:Plant Extracts