Synergistic activities of three triazoles with caspofungin against Candida glabrata isolates determined by time-kill, Etest, and disk diffusion methods.
Combinations of voriconazole, fluconazole, and itraconazole with caspofungin were evaluated against 50 Candida glabrata isolates by the time-kill, disk diffusion, and Etest methods. The majority of antifungal combinations were indifferent. By the time-kill method, synergistic activity was detected with eight (16%) of the caspofungin-voriconazole and seven (14%) of the caspofungin-fluconazole combinations, but synergy was not seen with the caspofungin-itraconazole combination. Further comparisons of the Etest and disk diffusion synergy techniques with the time-kill method are warranted.
Kiraz
Nuri
N
Department of Microbiology, Medical Faculty, University of Eskisehir Osmangazi, Eskisehir, Turkey. nkiraz@ogu.edu.tr
Dag
Ilknur
I
Yamac
Mustafa
M
Kiremitci
Abdurrahman
A
Kasifoglu
Nilgun
N
Oz
Yasemin
Y
D000935:Antifungal Agents / Q000494:pharmacology; D041221:Candida glabrata / Q000187:drug effects*; D000077336:Caspofungin; D052978:Disk Diffusion Antimicrobial Tests; D025141:Drug Resistance, Fungal / Q000187:drug effects; D004357:Drug Synergism; D054714:Echinocandins / Q000494:pharmacology*; D023381:Endpoint Determination; D015725:Fluconazole / Q000494:pharmacology*; D017964:Itraconazole / Q000494:pharmacology*; D055666:Lipopeptides; D011743:Pyrimidines / Q000494:pharmacology*; D013997:Time Factors; D014230:Triazoles / Q000494:pharmacology*; D065819:Voriconazole
D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D011743:Pyrimidines; D014230:Triazoles; D017964:Itraconazole; D015725:Fluconazole; D000077336:Caspofungin; D065819:Voriconazole