Novel inhibitors of basal glucose transport as potential anticancer agents.
Cancer cells commonly show increased levels of glucose uptake and dependence. A potential strategy for the treatment of cancer may be the inhibition of basal glucose transport. We report here the synthesis of a small library of polyphenolic esters that inhibit basal glucose transport in H1299 lung and other cancer cells. These basal glucose transport inhibitors also inhibit cancer cell growth in H1299 cells, and these two activities appear to be correlated.
Zhang
Weihe
W
Department of Chemistry & Biochemistry, Ohio University, Athens, OH 45701, USA.
Liu
Yi
Y
Chen
Xiaozhuo
X
Bergmeier
Stephen C
SC
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*; D059808:Polyphenols
D000970:Antineoplastic Agents; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols; D005947:Glucose