[Methodology overview of perfused rat intestine-liver preparation].
Since pang set up the perfused rat intestine-liver preparation and applied it to study the disposition of enalapril, this model has been widely considered to have the particularly advantage in studying the absorption, metabolism and first-pass effect. Now the methods and applications are to be reviewed and the perspective is to be discussed.
Wang
Yiwei
Y
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
Liang
Rixin
R
Yang
Weipeng
W
Wang
Yanli
Y
Weng
Xiaogang
X
Yang
Qing
Q
Wang
Lan
L
Zhu
Xiaoxin
X
D000818:Animals; D006801:Humans; D007408:Intestinal Absorption; D007422:Intestines / Q000737:chemistry / Q000502:physiology*; D008099:Liver / Q000737:chemistry / Q000502:physiology*; D023421:Models, Animal; D010477:Perfusion / Q000379:methods*; D051381:Rats