title: Serotonin transporter gene and inhibition of conflicting emotional information.
abstract: Genetic variation of the serotonin-transporter-linked promoter region has been reported to be associated with susceptibility to mood disorders. However, little is known about the behavioral characteristics that mediate this genetic variation and susceptibility to depression. We examined whether the serotonin-transporter genotype modulates inhibition of facial expressions and emotional words in the emotional 'face-word' Stroop task. Although negative word distractors interfered with the valence identification of positive faces among carriers of two short alleles, positive word distractors interfered with that of negative faces among carriers of one or two long alleles. We discuss a possible role of the reduced inhibitory control over semantic negative information in carriers of two short alleles in the risk of developing depressive mental state.
authors.affiliation: Department of Psychology, The University of Tokyo, Tokyo, Japan. ll087023@mail.ecc.u-tokyo.ac.jp
authors.forename: Ai
authors.initials: A
authors.lastname: Koizumi
authors.forename: Norimichi
authors.initials: N
authors.lastname: Kitagawa
authors.forename: Miho S
authors.initials: MS
authors.lastname: Kitamura
authors.forename: Hirohito M
authors.initials: HM
authors.lastname: Kondo
authors.forename: Takao
authors.initials: T
authors.lastname: Sato
authors.forename: Makio
authors.initials: M
authors.lastname: Kashino
mesh_terms: D000328:Adult; D001923:Brain Chemistry / Q000235:genetics*; D003220:Conflict, Psychological; D003463:Cues; D003866:Depressive Disorder / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009433:Neural Inhibition / Q000235:genetics*; D012701:Serotonin / Q000502:physiology; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics* / Q000502:physiology; D055815:Young Adult
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins; D012701:Serotonin