NOD-like receptor (NLR) signaling beyond the inflammasome.
Recent years have witnessed a marked progress in our knowledge of NOD-like receptors (NLR), intracellular sensors with central roles in innate and adaptive immunity. A majority of the research has focused on caspase-1 inflammasomes. However, several members of the mammalian NLR family exert important roles in immunity beyond inflammasome signaling. Here we highlight the emerging roles of several of these NLR.
Shaw
Patrick J
PJ
Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105-2794, USA.
Lamkanfi
Mohamed
M
Kanneganti
Thirumala-Devi
TD
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D046912:Multiprotein Complexes / Q000276:immunology*; D053472:Nod Signaling Adaptor Proteins / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
D046912:Multiprotein Complexes; D053472:Nod Signaling Adaptor Proteins