title: Fatal Clostridium difficile infection associated with vinorelbine chemotherapy: case report and literature review.
abstract: Differentiating between chemotherapy-related diarrhoea and Clostridium difficile-associated diarrhoea (CDAD) can be extremely difficult. There is increasing evidence that CDAD can be seen in patients on chemotherapy without prior antibiotic usage. We report the first case of CDAD secondary to vinorelbine chemotherapy and review the literature.
authors.affiliation: Beatson West of Scotland Cancer Centre, Glasgow, UK. jawaher.ansari@ggc.scot.nhs.uk
authors.forename: Jawaher
authors.initials: J
authors.lastname: Ansari
authors.forename: Bok
authors.initials: B
authors.lastname: Choo
authors.forename: Indrajit
authors.initials: I
authors.lastname: Fernando
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000382:microbiology; D016360:Clostridioides difficile / Q000302:isolation & purification*; D003967:Diarrhea / Q000139:chemically induced / Q000175:diagnosis / Q000382:microbiology; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced / Q000209:etiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D008532:Megacolon, Toxic / Q000139:chemically induced / Q000175:diagnosis / Q000382:microbiology; D008875:Middle Aged; D014747:Vinblastine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077235:Vinorelbine
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014747:Vinblastine; D000077235:Vinorelbine