Mitochondrial redox metabolism: aging, longevity and dietary effects.
Mitochondrial redox metabolism has long been considered to play important roles in mammalian aging and the development of age-related pathologies in the major oxidative organs. Both genetic and dietary manipulations of mitochondrial redox metabolism have been associated with the extension of lifespan. Here we provide a broad overview of the circumstantial evidence showing associations between mitochondrial reactive oxygen species (ROS) metabolism, aging and longevity. We address most aspects of mitochondrial ROS metabolism, from superoxide production, to ROS detoxification and the repair/removal of ROS-mediated macromolecular damage. Finally, we discuss the effects of dietary manipulations (e.g. caloric restriction, methionine restriction), dietary deficiencies (e.g. folate) and dietary supplementation (e.g. resveratrol) on mitochondrial ROS metabolism and lifespan.
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Melissa M
MM
Department of Biological Sciences, Brock University, St. Catharines, ON, Canada.
Robb
Ellen L
EL
Salway
Kurtis D
KD
Stuart
Jeffrey Alan
JA
D000375:Aging / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D031204:Caloric Restriction; D004032:Diet; D019587:Dietary Supplements; D008136:Longevity / Q000187:drug effects / Q000235:genetics; D008715:Methionine / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology*; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species; D008715:Methionine