title: Metabolic syndrome in children: comparison of the International Diabetes Federation 2007 consensus with an adapted National Cholesterol Education Program definition in 300 overweight and obese French children.
abstract: OBJECTIVE
  Former definitions of metabolic syndrome (MS) in children have been adapted from adult MS definitions using age-related thresholds for each biochemical component, whereas the International Diabetes Federation (IDF) definition is based on absolute values. We compared the IDF childhood MS definition (IDF-MS) to the adapted National Cholesterol Education Program (adapted-NCEP) definition in overweight children.
  
  
  METHODS
  300 overweight and obese children were included with a median age of 11 years and BMI SDS of +4.7.
  
  
  RESULTS
  Below 10 years of age, the frequency of MS according to the adapted-NCEP-MS definition was 18.6%, and 86.1% had abdominal obesity. In children aged 10 to <16 years (n = 214), the frequency of IDF-MS was 8.9% compared to 14.5% by adapted-NCEP. IDF-MS children had a larger waist circumference, and higher triglycerides, fasting insulin and tended to be older than the intermediate severity group of children with MS only according to adapted-NCEP. Children with MS only according to adapted-NCEP (IDF-MS negative), differed from non-MS children in systolic blood pressure, triglycerides and high-density lipoprotein cholesterol.
  
  
  CONCLUSIONS
  The recent IDF-MS criterion in children represents a more severe definition and appears to identify a group of children with higher fasting insulin than the adapted-MS definition which uses age-related thresholds (90th percentile).
authors.affiliation: MRC Epidemiology Unit, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. celine.druet@hmn.aphp.fr
authors.forename: Céline
authors.initials: C
authors.lastname: Druet
authors.forename: Ken
authors.initials: K
authors.lastname: Ong
authors.forename: Claire
authors.initials: C
authors.lastname: Levy Marchal
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D001794:Blood Pressure; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis; D007328:Insulin / Q000097:blood; D024821:Metabolic Syndrome / Q000145:classification / Q000175:diagnosis; D009765:Obesity / Q000175:diagnosis; D056128:Obesity, Abdominal; D050177:Overweight / Q000175:diagnosis; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference; D003245:Consensus Statements as Topic
chemical_list: D007328:Insulin; D014280:Triglycerides