title: Clinical characteristics and treatment outcomes of gastric cancer patients with isolated para-aortic lymph node involvement.
abstract: BACKGROUND
  Although gastric cancer with isolated para-aortic lymph node (PAN) involvement is considered an advanced disease, the clinical characteristics of it have not been comprehensively elucidated.
  
  
  METHODS
  We reviewed the medical records of 1,277 patients received palliative chemotherapy with advanced gastric cancer according to metastatic sites: PAN-only metastasis, single organ metastasis other than PAN, and multiple organ metastasis. Time to other organ metastasis (TTOM) was determined only in PAN-only metastasis group as the time interval between initial diagnosis of recurrence or de novo metastasis and confirming distant metastasis beyond PAN area.
  
  
  RESULTS
  The median overall survival (OS) of patients with PAN-only metastasis was significantly longer than that of patients with single organ metastasis other than PAN or multiple organ metastasis (13.8 months vs. 11.4 months vs. 8.4 months; P < 0.001). In the PAN-only metastasis group, patients with recurrent diseases showed longer TTOM beyond the PAN area (10.7 vs. 7.7 months; P = 0.037) and OS (23.8 vs. 12.8 months; P = 0.010) than those with de novo metastatic disease and it was validated by multivariate analysis.
  
  
  CONCLUSIONS
  Patients with isolated PAN metastasis showed an excellent prognosis compared with patients with metastasis at other sites and it was primarily evident in patients with recurrent PAN metastasis.
authors.affiliation: Center For Gastric Cancer, Research Institute and Hospital, National Cancer Center, 323 Ilsan-Ro, Ilsandong-Gu, Goyang, Gyeonggi 410-769, Republic of Korea.
authors.forename: In Hae
authors.initials: IH
authors.lastname: Park
authors.forename: Sun Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Young-Woo
authors.initials: YW
authors.lastname: Kim
authors.forename: Keun Won
authors.initials: KW
authors.lastname: Ryu
authors.forename: Jun Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Young-Iee
authors.initials: YI
authors.lastname: Park
authors.forename: Noe Kyeong
authors.initials: NK
authors.lastname: Kim
authors.forename: Sook Ryun
authors.initials: SR
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008198:Lymph Nodes; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D010166:Palliative Care / Q000379:methods*; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology*; D013534:Survival; D013997:Time Factors; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents