Serum total IgE levels and total eosinophil counts: relationship with treatment response in patients with acute asthma.
OBJECTIVE
To determine whether serum total IgE levels and total eosinophil counts have any relationship with the response to routine pharmacological treatment in patients with acute asthma.


METHODS
A cross-sectional study involving 162 patients with acute asthma. Serum total IgE levels, peripheral blood cell counts and eosinophil counts were determined. The treatment was adjusted for each patient according to the severity of asthma. Spirometry was performed at baseline and two weeks after the treatment. The patients were divided into two groups: high IgE (>100 IU/mL) and low IgE (<100 IU/mL). We compared the two groups in terms of the relationships between baseline values and final values (percentage change) for the following parameters: FEV1, FVC, FEF25-75%, peripheral white blood cell counts and eosinophil counts.


RESULTS
There were no significant differences between the groups regarding the percentage changes of the studied parameters. Nor were there significant differences between the groups regarding FEV1, FVC, and FEF25-75% (% of the predicted values) at baseline.


CONCLUSIONS
On the basis of these findings, we conclude that serum total IgE levels, peripheral white blood cell counts and eosinophil counts cannot predict the response to the pharmacological treatment of patients with acute asthma.
Razi
Ebrahim
E
Kashan University of Medical Sciences, Kashan, Iran. ebrahimrazi@yahoo.com
Moosavi
Gholam Abbass
GA
D000208:Acute Disease; D000328:Adult; D001249:Asthma / Q000188:drug therapy / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D004804:Eosinophils / Q000166:cytology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D011237:Predictive Value of Tests; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
D015415:Biomarkers; D007073:Immunoglobulin E