title: [Recurrence and survival after breast-conserving treatment of breast cancer].
abstract: BACKGROUND
  The objective of this retrospective study was to determine, within one institution, local relapse rate and survival for women with early-stage breast cancer treated with breast-conserving surgery followed by radiotherapy.
  
  
  METHODS
  All women with infiltrating early-stage breast cancer who underwent post-operative whole breast irradiation at our institution in the period 14.06.99-8.03.2002 were included in the study. A CT-based 3D dose calculation was performed in all patients.
  
  
  RESULTS
  222 women received 50 Gy whole-breast irradiation after breast-conserving surgery in the study period. 51 patients received adjuvant systemic therapy according to national guidelines. Median age at diagnosis was 59 years (34-82 years). Median tumour size was 12 mm (1-30 mm) and 86.5 % of the patients were N0. During a follow-up (median) of 96 months (28-111 months), local recurrence was observed in three of 222 patients (1.4 %; 95 % CI [0.5-4.4 %]) in the ipsilateral breast. The estimated 8-year breast-cancer specific survival was 95 % and total survival was 90 %.
  
  
  CONCLUSIONS
  Our data demonstrate excellent local disease control in women with low-risk early-stage breast cancer (about 25 % were on adjuvant systemic therapy) who undergo breast-conserving surgery and 50 Gy whole-breast irradiation.
authors.affiliation: Klinikk for blod- og kreftsykdommer, Stavanger universitetssjukehus, 4608 Stavanger, Norway. mjin@sus.no
authors.forename: Ingvil
authors.initials: I
authors.lastname: Mjaaland
authors.forename: Ron M P
authors.initials: RM
authors.lastname: Segers
authors.forename: Kjell Ivar
authors.initials: KI
authors.lastname: Dybvik
authors.forename: Ottar
authors.initials: O
authors.lastname: Bjerkeset
authors.forename: Jan Terje
authors.initials: JT
authors.lastname: Kvaløy
authors.forename: Reino
authors.initials: R
authors.lastname: Heikkilä
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000401:mortality / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009369:Neoplasms / Q000453:epidemiology; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016896:Treatment Outcome