[Mechanism of apoptosis in the thyroid cells in thyroid pathology].
The literature data and the results of own examinations concerning the changes in programmed cell death processes of goiter alterated thyroid tissue in patients with euthyroid or toxic goiter and also the extranodular tissue of the gland in the presence of pathological changes in it (the pronounced hyperplastic process, sclerotic and/or dystrophic changes, lymphoid infiltration, chronic or autoimmune thyroiditis) were analyzed. It has been shown that the significant changes in the processes ofmitochondria and postmitochondria regulation and apoptosis realization are occurred under thyroid pathology. The character and the degree of disorders in the apoptosis mitochondria mechanisms and the activity of destructive processes in the patient thyroid cells are dependent on many factors such as the type of pathology, the severity of its occurrence, the peculiarities of tissue follicular structure and the patient sex. Obtained resistance of the apoptosis mitochondria mechanisms can play an important role in the pathogenesis of thyroid nodular pathology or in the development of inflammatory and autoimmune processes.
Myshunina
T M
TM
Kalinichenko
O V
OV
Tron'ko
M D
MD
D017209:Apoptosis; D053148:Caspase 3 / Q000378:metabolism; D006801:Humans; D053078:Membrane Potential, Mitochondrial; D008933:Mitochondrial Swelling; D013959:Thyroid Diseases / Q000201:enzymology / Q000473:pathology*; D013961:Thyroid Gland / Q000201:enzymology / Q000473:pathology*
D053148:Caspase 3