[Association between insulin-like growth factor-1 receptor gene polymorphisms and with susceptibility to adolescent idiopathic scoliosis].
OBJECTIVE
To investigate the association of insulin-like growth factor-1 receptor (IGF-1R) gene polymorphisms and with susceptibility to adolescent idiopathic scoliosis (AIS).


METHODS
This study included 200 patients with AIS and 200 healthy controls. Height, menarche status, curve pattern, Cobb angle, and Risser sign in female patients were recorded. Blood samples were taken form each subject by venipuncture. Genetic DNA was extract from peripheral blood leukocytes using standard phenol/chloroform extraction. PCR-RFLP (polymerase chain reaction-restriction-fragment length polymorphism) was used for the genotyping.


RESULTS
The genotype and allele frequency distribution were similar between AIS and normal control (P>0.05). The mean maximum Cobb angle, Risser sign, menarche status of different genotypes of IGF-1R gene were similar with each other among female AIS patients (P>0.05).


CONCLUSIONS
The IGF-1R gene is neither associated with the occurrence nor the curve severity of AIS.
Liu
Wen-jun
WJ
Department of Spine Surgery, the Affiliated Drum Tower Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Qiu
Yong
Y
Chen
Zhi-jun
ZJ
Liu
Zhen
Z
Shu
Hao
H
Wang
Xin-hua
XH
Sun
Chao
C
D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D017526:Receptor, IGF Type 1 / Q000235:genetics*; D012600:Scoliosis / Q000235:genetics*; D055815:Young Adult
D017526:Receptor, IGF Type 1