Disseminated Scedosporium/Pseudallescheria infection after double-lung transplantation in patients with cystic fibrosis.
We report a case of disseminated Scedosporium/Pseudallescheria infection due to Pseudallescheria boydii sensu stricto after lung transplantation in a patient with cystic fibrosis. Dissemination occurred under voriconazole. Despite surgery and combination therapy with voriconazole, caspofungin, and terbinafine, the patient died 8 months after transplantation. Previously reported cases are reviewed.
Morio
Florent
F
Laboratoire de Parasitologie-Mycologie, CHU de Nantes, Hôtel Dieu, 9 Quai Moncousu, 44093 Nantes Cedex 1, France. florent.morio@chu-nantes.fr
Horeau-Langlard
Delphine
D
Gay-Andrieu
Françoise
F
Talarmin
Jean-Philippe
JP
Haloun
Alain
A
Treilhaud
Michelle
M
Despins
Philippe
P
Jossic
Frédérique
F
Nourry
Laurence
L
Danner-Boucher
Isabelle
I
Pattier
Sabine
S
Bouchara
Jean-Philippe
JP
Le Pape
Patrice
P
Miegeville
Michel
M
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging; D000077336:Caspofungin; D018890:Chemoprevention / Q000379:methods; D003550:Cystic Fibrosis / Q000628:therapy*; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D054714:Echinocandins / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D055666:Lipopeptides; D008172:Lung Diseases, Fungal / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D016040:Lung Transplantation / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008826:Microbial Sensitivity Tests; D008853:Microscopy; D008969:Molecular Sequence Data; D009281:Naphthalenes / Q000627:therapeutic use; D011541:Pseudallescheria / Q000145:classification / Q000166:cytology / Q000235:genetics / Q000302:isolation & purification*; D011743:Pyrimidines / Q000627:therapeutic use; D012331:RNA, Fungal / Q000235:genetics; D012339:RNA, Ribosomal, 28S / Q000235:genetics; D011859:Radiography; D021681:Scedosporium / Q000145:classification / Q000166:cytology / Q000235:genetics / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA; D000077291:Terbinafine; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
D000935:Antifungal Agents; D004271:DNA, Fungal; D054714:Echinocandins; D055666:Lipopeptides; D009281:Naphthalenes; D011743:Pyrimidines; D012331:RNA, Fungal; D012339:RNA, Ribosomal, 28S; D014230:Triazoles; D000077336:Caspofungin; D000077291:Terbinafine; D065819:Voriconazole