title: Mutations in Keap1 are a potential prognostic factor in resected non-small cell lung cancer.
abstract: BACKGROUND
  Mutations in Kelch-like ECH-associated protein 1 (Keap1) have been reported to protect tumor cells from chemotherapeutic agents. However, their prognostic significance in nonsmall cell lung cancer (NSCLC) is still unclear. In this study, we examined the effect of Keap1 gene mutations on survival and disease-free interval using resected primary NSCLC tissue.
  
  
  METHODS
  We retrospectively analyzed the tumors from 79 patients with completely resected pathological Stage I-II NSCLC for the presence of Keap1 gene mutations and examined the prognosis of the patients.
  
  
  RESULTS
  Keap1 gene mutations were detected in four patients (5.1%). The postoperative 5-year survival rate for patients with Keap1 mutations was significantly lower than those without a mutation (25% vs. 76%, P = 0.038). The postoperative 5-year disease-free survival rate for patients with a mutant Keap1 tumor was slightly lower than for patients with Keap1 wild-type tumors (25% vs. 66%, P = 0.057).
  
  
  CONCLUSIONS
  Keap1 gene mutations are likely to be associated with a worse prognosis and lower postoperative disease-free survival rates in pathological Stage I-II NSCLC.
authors.affiliation: Faculty of Medicine, Department of Thoracic Surgery, Kyoto University, Sakyo-Ku, Kyoto, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Takahashi
authors.forename: Makoto
authors.initials: M
authors.lastname: Sonobe
authors.forename: Toshi
authors.initials: T
authors.lastname: Menju
authors.forename: Ei
authors.initials: E
authors.lastname: Nakayama
authors.forename: Nobuya
authors.initials: N
authors.lastname: Mino
authors.forename: Shotaro
authors.initials: S
authors.lastname: Iwakiri
authors.forename: Shinjiro
authors.initials: S
authors.lastname: Nagai
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Sato
authors.forename: Ryo
authors.initials: R
authors.lastname: Miyahara
authors.forename: Kenichi
authors.initials: K
authors.lastname: Okubo
authors.forename: Toshiki
authors.initials: T
authors.lastname: Hirata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Date
authors.forename: Hiromi
authors.initials: H
authors.lastname: Wada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000401:mortality*; D018076:DNA, Complementary / Q000032:analysis; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011379:Prognosis; D012189:Retrospective Studies; D012907:Smoking; D015996:Survival Rate
chemical_list: D018076:DNA, Complementary