7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin: more potent analogs of platensimycin.
Carbonyl ylide cycloaddition strategy was employed in the synthesis of platensimycin analogs. 7-Phenylplatensimycin and 11-methyl-7-phenylplatensimycin are more potent analogs of platensimycin.
Jang
Ki Po
KP
Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151-747, Republic of Korea.
Kim
Chan Hyuk
CH
Na
Seong Wook
SW
Jang
Dong Seok
DS
Kim
Hiyoung
H
Kang
Heonjoong
H
Lee
Eun
E
D000218:Adamantane / Q000737:chemistry* / Q000494:pharmacology*; D062365:Aminobenzoates / Q000737:chemistry* / Q000494:pharmacology*; D000813:Anilides / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D016983:Enterococcus / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy*; D008826:Microbial Sensitivity Tests; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship
D062365:Aminobenzoates; D000813:Anilides; D000900:Anti-Bacterial Agents; D000218:Adamantane; C510909:platensimycin