title: Serum levels of the adipokine lipocalin-2 are increased in preeclampsia.
abstract: BACKGROUND
  Preeclampsia (PE) is a serious complication in pregnancy which increases the future risk for vascular and metabolic disease in both mother and newborn. Recently, lipocalin-2 has been introduced as a novel adipokine which contributes to obesity, insulin resistance, and vascular disease.
  
  
  OBJECTIVE
  In the current study, we investigated lipocalin-2 serum levels in PE patients as compared to healthy gestational age-matched controls.
  
  
  METHODS
  Lipocalin-2 serum concentrations were quantified by enzyme-linked immunosorbent assay in control (no.=22) and PE (no.=22) patients. Furthermore, lipocalin-2 levels were correlated to clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation.
  
  
  RESULTS
  Median maternal lipocalin-2 concentrations were significantly increased in PE (121.3 μg/l) as compared to control subjects (99.8 μg/l) (p<0.05). Furthermore, circulating lipocalin 2 correlated positively with diastolic blood pressure, creatinine, and C reactive protein. In multivariate analyses, creatinine and C reactive protein remained independently associated with lipocalin-2 levels.
  
  
  CONCLUSIONS
  We demonstrate that maternal lipocalin-2 concentrations are significantly increased in PE. Furthermore, markers of renal function and inflammation independently predict circulating lipocalin-2.
authors.affiliation: Department of Obstetrics, University of Leipzig, Liebigstrasse 20, Leipzig, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Stepan
authors.forename: A
authors.initials: A
authors.lastname: Philipp
authors.forename: M
authors.initials: M
authors.lastname: Reiche
authors.forename: K
authors.initials: K
authors.lastname: Klostermann
authors.forename: S
authors.initials: S
authors.lastname: Schrey
authors.forename: C
authors.initials: C
authors.lastname: Reisenbüchler
authors.forename: U
authors.initials: U
authors.lastname: Lossner
authors.forename: J
authors.initials: J
authors.lastname: Kratzsch
authors.forename: M
authors.initials: M
authors.lastname: Bluher
authors.forename: M
authors.initials: M
authors.lastname: Stumvoll
authors.forename: M
authors.initials: M
authors.lastname: Fasshauer
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis; D054392:Adipokines / Q000032:analysis / Q000097:blood; D000328:Adult; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005865:Gestational Age; D006801:Humans; D007677:Kidney Function Tests; D000071068:Lipocalin-2; D054834:Lipocalins / Q000032:analysis / Q000097:blood*; D015999:Multivariate Analysis; D009994:Osmolar Concentration; D011225:Pre-Eclampsia / Q000097:blood* / Q000503:physiopathology; D011247:Pregnancy; D011518:Proto-Oncogene Proteins / Q000032:analysis / Q000097:blood*; D055815:Young Adult
chemical_list: D000209:Acute-Phase Proteins; D054392:Adipokines; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins