[Stability of some medicinal solutions with captopril].
The aim of the study was to investigate the stability of some oral liquid formulations containing 1 mg/ml captopril.


METHODS
The oral solutions were prepared using captopril substance, keeping the formulation as simple as possible to avoid potentially undesirable excipients. Samples were stored for 39 days below 8 degrees C and at 22 +/- 3 degrees C and analysed for physical, chemical and microbiological stability.


RESULTS
The formulations with ascorbic acid are stable for seven days either at 8 and 22 degrees C and could be prepared in hospital pharmacy as a more safely alternative to children terapy with tablets powders.
Imre
Silvia
S
Facultatea de Farmacie, Disciplina de Analiza Medicamentului, Universitatea de Medicină si Farmacie din Târgu-Mureş.
Vancea
Szende
S
Muntean
Daniela Lucia
DL
Sipos
Emese
E
Cociş
Adela
A
Avrigeanu
Veronica
V
Mircia
Eleonora
E
D000959:Antihypertensive Agents / Q000493:pharmacokinetics*; D002216:Captopril / Q000493:pharmacokinetics*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D004356:Drug Storage; D006801:Humans; D019999:Pharmaceutical Solutions; D013696:Temperature
D000959:Antihypertensive Agents; D019999:Pharmaceutical Solutions; D002216:Captopril