title: Complete response of anaplastic pancreatic carcinoma to paclitaxel treatment selected by chemosensitivity testing.
abstract: A 58-year-old woman was admitted to our institute in June 2007 because of obstructive jaundice. A mass in the pancreatic head and multiple swollen lymph nodes surrounding the common hepatic artery were identified using computed tomography (CT). Subsequently, endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNA) was done. Histopathologic results revealed anaplastic carcinoma of the pancreas. Using specimens obtained with EUS-FNA, chemosensitivity testing with adenosine triphosphate assay was performed. Testing indicated high chemosensitivity to paclitaxel (PTX). According to this result, chemotherapy using PTX was performed, and the primary lesion and lymph node metastases disappeared completely on CT. The patient has been doing well with no recurrence for 1 year and 11 months since initial chemotherapy.
authors.affiliation: Department of Internal Medicine 2, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. wakachan@fmu.ac.jp
authors.forename: Takeru
authors.initials: T
authors.lastname: Wakatsuki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Irisawa
authors.forename: Hidemichi
authors.initials: H
authors.lastname: Imamura
authors.forename: Masanori
authors.initials: M
authors.lastname: Terashima
authors.forename: Goro
authors.initials: G
authors.lastname: Shibukawa
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Takagi
authors.forename: Yuta
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Ai
authors.initials: A
authors.lastname: Sato
authors.forename: Masaki
authors.initials: M
authors.lastname: Sato
authors.forename: Tsunehiko
authors.initials: T
authors.lastname: Ikeda
authors.forename: Rei
authors.initials: R
authors.lastname: Suzuki
authors.forename: Takuto
authors.initials: T
authors.lastname: Hikichi
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Obara
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Ohira
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D001707:Biopsy, Needle; D002277:Carcinoma / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D019160:Endosonography; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D017239:Paclitaxel / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D050257:Tubulin Modulators / Q000627:therapeutic use*
chemical_list: D050257:Tubulin Modulators; D000255:Adenosine Triphosphate; D017239:Paclitaxel