title: Childhood lichen sclerosus: a long-term follow-up.
abstract: Lichen sclerosus (LS) shows a predilection for the genital area and occurs mostly in postmenopausal women and in prepubertal girls. We conducted a retrospective review of 15 young girls whit genital LS with onset before the menarcheal age and treated with topical clobetasol propionate 0.05%. The mean duration of follow-up was 4.7 years with relapses in nine patients after approximately 1 year from the first clearing. At the end of the study we observed that (i) potent topical steroids are safe and effective in childhood, (ii) an early aggressive treatment gives the best therapeutic response, (iii) one follow-up visit a year is required to monitor for relapsing.
authors.affiliation: Dermatology, Department of Internal Medicine, Oldness and Nephrologic Diseases, University of Bologna, Bologna, Italy. annalisa.patrizi@unibo.it
authors.forename: Annalisa
authors.initials: A
authors.lastname: Patrizi
authors.forename: C
authors.initials: C
authors.lastname: Gurioli
authors.forename: M
authors.initials: M
authors.lastname: Medri
authors.forename: I
authors.initials: I
authors.lastname: Neri
mesh_terms: D000287:Administration, Topical; D000367:Age Factors; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001284:Atrophy; D002648:Child; D002675:Child, Preschool; D002990:Clobetasol / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D012189:Retrospective Studies; D055502:Secondary Prevention; D016896:Treatment Outcome; D007724:Vulvar Lichen Sclerosus / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D000893:Anti-Inflammatory Agents; D002990:Clobetasol