Cutaneous macroglobulinosis deposits in a patient with IgM paraproteinemia/incipient Waldenström macroglobulinemia.
A 43-year-old healthy patient developed disseminated flat skin-colored to red-brown papules over a few months. These papules were the result of cutaneous IgM deposits representing the first symptom of a hitherto undiagnosed IgM paraproteinemia. This extremely rare skin manifestation of IgM paraproteinemia e. g. possibly incipient Waldenström macroglobulinemia should be included in the histopathological differential of eosinophilic dermal deposits.
Lüftl
Matthias
M
Dermatohistopathological Laboratory, Munich, Germany. lueftl@derma-muenchner-freiheit.de
Sauter-Jenne
Birthe
B
Gramatzki
Martin
M
Eckert
Fritjof
F
Jenne
Lars
L
D000328:Adult; D003937:Diagnosis, Differential; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D008259:Macroglobulins; D008297:Male; D010265:Paraproteinemias / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*; D011694:Purpura, Hyperglobulinemic / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*; D016896:Treatment Outcome
D007075:Immunoglobulin M; D008259:Macroglobulins