title: Passerini three-component reaction of alcohols under catalytic aerobic oxidative conditions.
abstract: Alcohols instead of aldehydes were used in the Passerini three-component reaction under catalytic aerobic conditions. Mixing alcohols, isocyanides, and carboxylic acids in toluene in the presence of a catalytic amount of cupric chloride, NaNO(2), and TEMPO afforded, under an oxygen atmosphere, the P-3CR adducts in good yields.
authors.affiliation: Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Brioche
authors.forename: Géraldine
authors.initials: G
authors.lastname: Masson
authors.forename: Jieping
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000447:Aldehydes / Q000138:chemical synthesis / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D010100:Oxygen / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000447:Aldehydes; D002264:Carboxylic Acids; D003486:Cyanides; D010100:Oxygen