Host determinants of HIV-1 control in African Americans.
We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene showed one of the strongest associations. We use a subset of patients to demonstrate that this SNP reflects the effect of the HLA-B*5703 allele, which shows a genome-wide statistically significant association with viral load set point (P = 5.6 x 10(-10)). These analyses therefore confirm a member of the HLA-B*57 group of alleles as the most important common variant that influences viral load variation in African Americans, which is consistent with what has been observed for individuals of European ancestry, among whom the most important common variant is HLA-B*5701.
Pelak
Kimberly
K
Center for Human Genome Variation, Duke University Medical School, Durham, North Carolina, USA.
Goldstein
David B
DB
Walley
Nicole M
NM
Fellay
Jacques
J
Ge
Dongliang
D
Shianna
Kevin V
KV
Gumbs
Curtis
C
Gao
Xiaojiang
X
Maia
Jessica M
JM
Cronin
Kenneth D
KD
Hussain
Shehnaz K
SK
Carrington
Mary
M
Michael
Nelson L
NL
Weintrob
Amy C
AC
D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000276:immunology; D018450:Disease Progression; D055106:Genome-Wide Association Study; D005838:Genotype; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D015235:HLA-B Antigens / Q000235:genetics / Q000276:immunology; D015236:HLA-C Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D019562:Viral Load / Q000235:genetics; D055815:Young Adult
D004268:DNA-Binding Proteins; D015235:HLA-B Antigens; C496219:HLA-B*57:03 antigen; D015236:HLA-C Antigens; C406241:POLR1H protein, human