title: Fresh-socket implants in periapical infected sites in humans.
abstract: BACKGROUND
  The aim of the present study is to compare the outcome of the immediate placement of implants when used in the replacement of teeth with and without chronic periapical lesions.
  
  
  METHODS
  Thirty patients requiring a single-tooth extraction of a monoradicular or premolar tooth were selected. The control group (CG) included 15 patients without periapical lesions but with root caries and root fractures. The test group (TG) included 15 patients with periapical lesions, periapical radiolucencies, and no signs of pain, fistulas, or suppuration. Thirty teeth were extracted, and implants were immediately positioned in fresh sockets and loaded after 3 months in both groups. Clinical parameters (probing depth [PD], modified plaque index, modified bleeding index [mBI], marginal gingiva level [MGL], and keratinized mucosa [KM]) and marginal bone levels were evaluated at baseline and 12 and 24 months after implant placement. Comparisons between CG and TG values over time were performed by the Student two-tailed t test.
  
  
  RESULTS
  At the 24-month follow-up, a survival rate of 100% was reported for all implants. The mean bone loss was 0.82 +/- 0.52 mm for the CG and 0.86 +/- 0.54 for the TG. Plaque accumulation was 0.74 +/- 0.29 for the CG and 0.69 +/- 0.29 for the TG. The mBI was 0.77 +/- 0.33 for the CG and 0.72 +/- 0.36 for the TG. The soft tissue profile MGL and KM remained stable for up to 24 months for the CG and TG. The mean PD was 2.05 +/- 0.66 mm for the CG and 1.99 +/- 0.57 mm for the TG. Differences that were not statistically significant were reported between the CG and TG over time and between time points.
  
  
  CONCLUSIONS
  At the 24-month follow-up, endosseous implants placed immediately in extraction sites affected by periapical infection rendered an equally favorable soft and hard tissue integration of the implants, revealing a predictable outcome.
authors.affiliation: Department of Dentistry, Vita Salute University, San Raffaele Hospital, Milan, Italy. robcresp@libero.it
authors.forename: Roberto
authors.initials: R
authors.lastname: Crespi
authors.forename: Paolo
authors.initials: P
authors.lastname: Capparè
authors.forename: Enrico
authors.initials: E
authors.lastname: Gherlone
mesh_terms: D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000150:complications / Q000473:pathology; D003758:Dental Implantation, Endosseous / Q000379:methods*; D019250:Dental Implants, Single-Tooth; D003799:Dental Stress Analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016348:Osseointegration; D010485:Periapical Periodontitis / Q000150:complications*; D010512:Periodontal Index; D011446:Prospective Studies; D017213:Root Caries / Q000150:complications / Q000601:surgery; D013997:Time Factors; D014081:Tooth Extraction; D014082:Tooth Fractures / Q000150:complications / Q000601:surgery; D020390:Tooth Socket / Q000601:surgery*; D016896:Treatment Outcome