Neuropeptide Y and sex hormone interactions in humoral and neuronal regulation of bone and fat.
The hypothalamus regulates the skeleton and adipose tissue via endocrine mechanisms. Changes in sex steroid levels in menopause and aging are central to the associated changes in bone mass and adiposity. Whereas many of these effects occur via direct actions on osteoblasts or adipocytes, sex hormones can also mediate effects on bone and adipose tissue via interaction with neuronal pathways. A key hypothalamic regulator of bone and adipose tissue is neuropeptide Y (NPY), which coordinately influences these tissues via effects on neuroendocrine and sympathetic nervous output. Better understanding of the interaction between NPY and sex steroids in regulating skeletal and energy homeostasis could lead to more effective treatments for osteoporosis and obesity.
Zengin
Ayse
A
Osteoporosis and Bone Biology Program, Garvan Institute of Medical Research, St Vincent's Hospital, Darlinghurst, Sydney, New South Wales (NSW), Australia.
Zhang
Lei
L
Herzog
Herbert
H
Baldock
Paul A
PA
Sainsbury
Amanda
A
D000273:Adipose Tissue / Q000502:physiology*; D000818:Animals; D001842:Bone and Bones / Q000502:physiology*; D012739:Gonadal Steroid Hormones / Q000502:physiology*; D006801:Humans; D007031:Hypothalamus / Q000502:physiology*; D009478:Neuropeptide Y / Q000502:physiology*
D012739:Gonadal Steroid Hormones; D009478:Neuropeptide Y