Parkinson's disease: oxidative stress and therapeutic approaches.
Parkinson's disease (PD) is a neurodegenerative disorder, caused by reduced levels of catecholamines and oxidative stress. Symptoms seen in the disease include tremor, rigidity, bradykinesia and postural disability. Oxidative stress plays a key role in neurodegeneration and motor abnormalities seen in PD. Altered levels of the protein caused by these changes lead to defective ubiquitin-proteasome pathway. Neurodegeneration seen in PD and Canavan disease has a common mechanism. Recent studies suggest that herbal medicines can improve molecular changes and motor functions seen in PD.
Surendran
Sankar
S
School of Medicine, LSUHSC, New Orleans, LA 70112, USA. sankar_surendran@yahoo.com
Rajasankar
Srinivasagam
S
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002395:Catecholamines / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D014452:Ubiquitins / Q000378:metabolism
D000975:Antioxidants; D002395:Catecholamines; D014452:Ubiquitins; D001224:Aspartic Acid; D009569:Nitric Oxide; C000179:N-acetylaspartate; D046988:Proteasome Endopeptidase Complex