Diabetes--adult stem cells as an future alternative therapy?
In both types of the diabetes mellitus, the lack of functional beta-cells is crucial, leading to complications associated with development of hyperglycaemia. One way to achieve a constant normoglycemic state without hypoglycemic episodes is either whole pancreas transplantation, or transplantation of isolated islets of Langerhans. Another approach to correct the beta-cell deficit is the stimulation of beta-cells in pancreas to regeneration. The development of new diabetes therapy is the main goal for many scientists around the world. This article is focused on the stem cells and their potential for clinical applications (Ref. 47).
Ulicna
M
M
Institute of Medical Biology, Genetics and Clinical Genetics, Faculty of Medicine, Comenius University, Bratislava, Slovakia. marcela.ulicna@fmed.uniba.sk
Danisovic
L
L
Danihel
L
L
Vojtassak
J
J
D053687:Adult Stem Cells / Q000637:transplantation*; D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007515:Islets of Langerhans / Q000502:physiology; D012038:Regeneration