title: The PROTON study: profiles of blood product transfusion recipients in the Netherlands.
abstract: BACKGROUND
  Transfusion recipient data are needed for correct estimation of cost-effectiveness in terms of recipient outcomes after transfusion. Also, such data are essential for monitoring blood use, estimation of future blood use and benchmarking.
  
  
  METHODS
  A sample of 20 of 93 Dutch hospitals was selected. Datasets containing all blood product transfusions between 1996 and 2006 were extracted from hospital blood bank computer systems, containing transfusion date, blood product type and recipient characteristics such as gender, address, date of birth. The datasets were appended and matched to national hospitalization datasets including primary discharge diagnoses (ICD-9). Using these data, we estimated distributions of blood recipient characteristics in the Netherlands.
  
  
  RESULTS
  The dataset contains information on 290,043 patients who received 2,405,012 blood products (1,720,075 RBC, 443,697 FFP, 241,240 PLT) from 1996 to 2006. This is 28% of total blood use in the Netherlands during this period. Comparable diagnosis and age distributions of all hospitalizations indicate included hospitals to be representative, per hospital category, for the Netherlands. Of all red blood cells (RBC), fresh-frozen plasma (FFP) and platelets (PLT), respectively 1.7%, 2.5% and 4.5% were transfused to neonates. Recipients of 65 years or older received 57.6% of RBC, 41.4% of FFP and 29.0% of PLT. Most of the blood products were transfused to patients with diseases of the circulary system (25.1%) or neoplasms (22.0%).
  
  
  CONCLUSIONS
  Transfusion data from a limited sample of hospitals can be used to estimate national distributions of blood recipient characteristics.
authors.affiliation: Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
authors.forename: B A
authors.initials: BA
authors.lastname: Borkent-Raven
authors.forename: M P
authors.initials: MP
authors.lastname: Janssen
authors.forename: C L
authors.initials: CL
authors.lastname: van der Poel
authors.forename: W P
authors.initials: WP
authors.lastname: Schaasberg
authors.forename: G J
authors.initials: GJ
authors.lastname: Bonsel
authors.forename: B A
authors.initials: BA
authors.lastname: van Hout
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001803:Blood Transfusion / Q000191:economics / Q000706:statistics & numerical data*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008875:Middle Aged; D009426:Netherlands; D012737:Sex Factors; D016896:Treatment Outcome; D055815:Young Adult