Synthesis, structural characterisation and antibacterial activity of bis(1-phenyl-1,3-butanedionato)non-oxovanadium(IV) hydroxamates.
Complexes with a composition of VCl(2-n)(bzac)(2)(HL(1,2))(n) (I - IV) (where bzac = 1-phenyl-1,3-butanedionate anion (C(6)H(5)COCHCOCH(3)(-)); HL(1)=C(6)H(5)OCH(2)C(O)NHO(-), HL(2) = C(6)H(5)CH=CHC(O)NHO(-), n = 1 and 2) have been synthesised from the reactions of (VCl(2)(bzac)(2)) with equi- and bi-molar amounts of potassium phenoxyacetohydroxamate and cinnamohydroxamate (KHL(1,2)) in THF + MeOH solvent medium. The complexes have been characterised by elemental analyses, molar conductivity, magnetic measurements, IR, electronic and mass spectral studies. The physicochemical and spectral studies suggest a distorted octahedral geometry around vanadium in the complexes. The antibacterial activities of the newly synthesised complexes, vanadium precursor and ligands have been screened in vitro against six bacterial species. The complexes have shown higher antibacterial effect than the free ligands.
Sharma
Neeraj
N
Department of Chemistry, Himachal Pradesh University, Summer Hill, Shimla 171005, India. neerajsharma_univ@yahoo.co.in
Kumari
Meena
M
Kumar
Vijay
V
Chaudhry
S C
SC
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D044482:Benzeneacetamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D055598:Chemical Phenomena; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004553:Electric Conductivity; D004755:Enterobacteriaceae / Q000187:drug effects; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013053:Spectrophotometry; D013054:Spectrophotometry, Atomic; D017550:Spectroscopy, Fourier Transform Infrared; D013210:Staphylococcus / Q000187:drug effects; D014639:Vanadium / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D044482:Benzeneacetamides; D056831:Coordination Complexes; D006877:Hydroxamic Acids; D014639:Vanadium