title: Clear cell carcinoma of the bladder in a patient with a earlier clear cell renal cell carcinoma: a case report with morphologic, immunohistochemical, and cytogenetical analysis.
abstract: Clear cell transitional carcinoma of the bladder is a subtype of transitional carcinoma that morphologically resembles a clear cell renal cell carcinoma. Although kidney tumors do not frequently metastasize to the bladder, the recurrence after a clear cell renal cell carcinoma has been reported even several years after nephrectomy. We report the case of a male patient to whom radical nephrectomy for a clear cell renal cell carcinoma has been done, with a bladder tumor featuring polygonal cells with abundant clear cytoplasm deeply infiltrating the vesical wall. We discuss the morphologic features, the immunohistochemical staining with a new marker and the UroVysion FISH analysis to achieve a definitive diagnosis.
authors.affiliation: Department of Human Pathology and Oncology, University of Florence, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Rotellini
authors.forename: Cristina
authors.initials: C
authors.lastname: Fondi
authors.forename: Milena
authors.initials: M
authors.lastname: Paglierani
authors.forename: Niceta
authors.initials: N
authors.lastname: Stomaci
authors.forename: Maria Rosaria
authors.initials: MR
authors.lastname: Raspollini
mesh_terms: D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000473:pathology*; D003937:Diagnosis, Differential; D020022:Genetic Predisposition to Disease; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D001749:Urinary Bladder Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000556:secondary*; D019459:Urothelium / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor