Long-term treatment with shengmai san-derived herbal supplement (Wei Kang Su) enhances antioxidant response in various tissues of rats with protection against carbon tetrachloride hepatotoxicity.
Wei Kang Su (WKS) is a commercial herbal product based on a Chinese herbal formula, Shengmai San. Here, we investigated the effects of long-term treatment with WKS on mitochondrial antioxidant status and functional ability, as well as heat shock protein (Hsp) 25/70 production, in various tissues of rats. WKS treatment enhanced mitochondrial antioxidant status and ATP generation capacity, as well as Hsp 25/70 production in various rat tissues. WKS treatment suppressed plasma reactive oxygen metabolite levels and protected against carbon tetrachloride hepatotoxicity in rats. Long-term WKS treatment may prevent diseases by enhancing the resistance of mitochondria to oxidative stress.
Leong
Pou Kuan
PK
Department of Biochemistry, Hong Kong University of Science & Technology, Hong Kong Special Administrative Region, China.
Chen
Na
N
Chiu
Po Yee
PY
Leung
Hoi Yan
HY
Ma
Chung Wah
CW
Tang
Qing Tao
QT
Ko
Kam Ming
KM
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy* / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D050886:HSP20 Heat-Shock Proteins / Q000096:biosynthesis; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis; D019684:Magnoliopsida; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D031441:Ophiopogon; D018384:Oxidative Stress / Q000187:drug effects*; D005894:Panax; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000097:blood; D032141:Schisandra
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D050886:HSP20 Heat-Shock Proteins; D018840:HSP70 Heat-Shock Proteins; D017382:Reactive Oxygen Species; D000255:Adenosine Triphosphate