Mammalian ceramide synthases.
In mammals, ceramide, a key intermediate in sphingolipid metabolism and an important signaling molecule, is synthesized by a family of six ceramide synthases (CerS), each of which synthesizes ceramides with distinct acyl chain lengths. There are a number of common biochemical features between the CerS, such as their catalytic mechanism, and their structure and intracellular localization. Different CerS also display remarkable differences in their biological properties, with each of them playing distinct roles in processes as diverse as cancer and tumor suppression, in the response to chemotherapeutic drugs, in apoptosis, and in neurodegenerative diseases.
Levy
Michal
M
Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel.
Futerman
Anthony H
AH
D000818:Animals; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D009369:Neoplasms / Q000201:enzymology; D013110:Sphingosine / Q000031:analogs & derivatives / Q000378:metabolism; D051049:Sphingosine N-Acyltransferase / Q000378:metabolism*; D025521:Tumor Suppressor Proteins / Q000378:metabolism
D008565:Membrane Proteins; D025521:Tumor Suppressor Proteins; C493790:CERS1 protein, human; C438311:CERS2 protein, human; C505722:CERS5 protein, human; C506123:CERS6 protein, human; C513562:CerS3 protein, mouse; D051049:Sphingosine N-Acyltransferase; D013110:Sphingosine; C005682:safingol