A new jacaranone derivative from Senecio scandens var. incisus.
A new jacaranone derivative, 2-(1,6-dihydroxy-4-oxocyclohex-2-enyl) acetic acid (1), has been isolated from the whole plants of Senecio scandens var. incisus, together with three known compounds: 2'-(p-hydroxyl-cinnamoyl)-6'-jacaranone-D-glucopyranoside (2), 2'-caffeoyl-6'-jacaranone-D-glucopyranoside (3) and kampferol-3-rhamnoside (4). Their structures were elucidated on the basis of spectroscopic data analyses and by comparison with the related known compounds. Cytotoxic activities of 1 against three human tumour cell lines have been evaluated by the MTT method.
Wang
Wen-Shu
WS
College of Life and Environment Science, MINZU University of China, Beijing, China. wangwshu@gmail.com
Lu
Peng
P
Duan
Chang-Hong
CH
Feng
Jin-Chao
JC
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D012674:Senecio / Q000737:chemistry*; D013057:Spectrum Analysis / Q000379:methods
D000972:Antineoplastic Agents, Phytogenic; D016227:Benzoquinones; C013077:jacaranone