Pharmacodynamics of a losartan transdermal system for the treatment of hypertension.
OBJECTIVE
Transdermal therapeutic systems were developed using the polymers, Eudragit E 100 and polyvinyl pyrrolidone VA 64 in a film casting assembly. The medicated films were evaluated for physical properties, in vitro drug release studies, in vitro skin permeation studies, and pharmacodynamic studies.


RESULTS
The physical parameters were found to be very satisfactory with high drug content (>99%). The in vitro drug release studies were performed using paddle-over-disc assembly specified in USP XXIII. The pharmacodynamic studies were carried out using tail cuff method in Wistar albino rats. Hypertension was induced by methyl prednisolone acetate subcutaneously for 2 weeks. The developed matrix patch was found to decrease the blood pressure (25.42% reduction in mean systolic blood pressure of rats) significantly (P < 0.001) in proximity of the normal value and it was maintained for 24 hours.


CONCLUSIONS
It can be concluded that the developed transdermal matrix patch holds promise for the management of hypertension that needs to be validated by clinical trials.
Shams
M Shahbaz
MS
Department of Pharmaceutics, Faculty of Pharmacy, Jamia Hamdard, New Delhi, India.
Alam
M Intakhab
MI
Ali
Asgar
A
Sultana
Yasmin
Y
Aqil
M
M
D000179:Acrylates; D000279:Administration, Cutaneous; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D004355:Drug Stability; D006973:Hypertension / Q000188:drug therapy*; D019808:Losartan / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D010539:Permeability; D011108:Polymers; D011205:Povidone / Q000031:analogs & derivatives; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000378:metabolism
D000179:Acrylates; D000959:Antihypertensive Agents; D003692:Delayed-Action Preparations; C477020:Eudragit E100; D011108:Polymers; C077842:polyvinylpolypyrrolidone; D011205:Povidone; D019808:Losartan