Complete response of anaplastic pancreatic carcinoma to paclitaxel treatment selected by chemosensitivity testing.
A 58-year-old woman was admitted to our institute in June 2007 because of obstructive jaundice. A mass in the pancreatic head and multiple swollen lymph nodes surrounding the common hepatic artery were identified using computed tomography (CT). Subsequently, endoscopic ultrasonography-guided fine-needle aspiration biopsy (EUS-FNA) was done. Histopathologic results revealed anaplastic carcinoma of the pancreas. Using specimens obtained with EUS-FNA, chemosensitivity testing with adenosine triphosphate assay was performed. Testing indicated high chemosensitivity to paclitaxel (PTX). According to this result, chemotherapy using PTX was performed, and the primary lesion and lymph node metastases disappeared completely on CT. The patient has been doing well with no recurrence for 1 year and 11 months since initial chemotherapy.
Wakatsuki
Takeru
T
Department of Internal Medicine 2, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. wakachan@fmu.ac.jp
Irisawa
Atsushi
A
Imamura
Hidemichi
H
Terashima
Masanori
M
Shibukawa
Goro
G
Takagi
Tadayuki
T
Takahashi
Yuta
Y
Sato
Ai
A
Sato
Masaki
M
Ikeda
Tsunehiko
T
Suzuki
Rei
R
Hikichi
Takuto
T
Obara
Katsutoshi
K
Ohira
Hiromasa
H
D000255:Adenosine Triphosphate / Q000378:metabolism; D001707:Biopsy, Needle; D002277:Carcinoma / Q000188:drug therapy* / Q000378:metabolism / Q000556:secondary; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D019160:Endosonography; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D017239:Paclitaxel / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D050257:Tubulin Modulators / Q000627:therapeutic use*
D050257:Tubulin Modulators; D000255:Adenosine Triphosphate; D017239:Paclitaxel