title: Modulation of age-related NF-kappaB activation by dietary zingerone via MAPK pathway.
abstract: Zingerone, a major component found in ginger root, has been known as anti-mutagenic and anti-carcinogenic activities that are often associated with its anti-oxidative and anti-inflammatory activities. In recent studies, we examined molecular mechanism of zingerone treatment on pro-inflammatory NF-kappaB activation via the redox-related NIK/IKK and MAPK pathways. Action mechanism of zingerone on NF-kappaB signaling was investigated in aged rat kidney and endothelial cells. The results showed that zingerone had not only the antioxidant effect by constitutive suppression of ROS, but also anti-inflammatory effects by suppression of nuclear factor (NF)-kappaB activation in aged rat. In addition, zingerone treatment suppressed gene activation of pro-inflammatory enzymes, COX-2 and iNOS, which were upregulated with aging through NF-kappaB activation and IKK/MAPK signaling pathway. These experiments strongly indicate that zingerone treatment exerts a beneficial efficacy by suppressing both oxidative stress and age-related inflammation through the modulation of several key pro-inflammatory genes and transcription factors. Thus, the significance of our findings is that the zingerone treatment may provide some preventive measure against chronic inflammatory conditions that underlie many age-related inflammatory diseases, such as metabolic syndrome, cardiovascular disease, dementia, arthritis, diabetes, osteoprosis, and cancers.
authors.affiliation: Department of Pharmacy, Pusan National University, Busan, South Korea.
authors.forename: Mi Kyung
authors.initials: MK
authors.lastname: Kim
authors.forename: Sang Woon
authors.initials: SW
authors.lastname: Chung
authors.forename: Dae Hyun
authors.initials: DH
authors.lastname: Kim
authors.forename: Ji Min
authors.initials: JM
authors.lastname: Kim
authors.forename: Eun Kyeong
authors.initials: EK
authors.lastname: Lee
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Ha
authors.forename: Yun Hee
authors.initials: YH
authors.lastname: Kim
authors.forename: Jae-Kyung
authors.initials: JK
authors.lastname: No
authors.forename: Hye Sun
authors.initials: HS
authors.lastname: Chung
authors.forename: Kun-Young
authors.initials: KY
authors.lastname: Park
authors.forename: Sook Hee
authors.initials: SH
authors.lastname: Rhee
authors.forename: Jae Sue
authors.initials: JS
authors.lastname: Choi
authors.forename: Byung Pal
authors.initials: BP
authors.lastname: Yu
authors.forename: Takako
authors.initials: T
authors.lastname: Yokozawa
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Hae Young
authors.initials: HY
authors.lastname: Chung
mesh_terms: D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D015153:Blotting, Western; D031204:Caloric Restriction; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D020935:MAP Kinase Signaling System / Q000187:drug effects* / Q000502:physiology; D020928:Mitogen-Activated Protein Kinases / Q000187:drug effects / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism* / Q000494:pharmacology; D052247:Nitric Oxide Synthase Type II; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D016328:NF-kappa B; D017382:Reactive Oxygen Species; C013738:zingerone; D006139:Guaiacol; D052247:Nitric Oxide Synthase Type II; D020928:Mitogen-Activated Protein Kinases