Cocaine and beta-blockers: the paradigm.
Cocaine is one of the most commonly used substances of abuse. The use of beta-blockers in cocaine induced acute coronary syndrome has long been a matter of debate. While it is widely believed that beta-blockers are contraindicated in cocaine toxicity, there appears to be some recognizable role for certain beta-blockers in ameliorating the cardiovascular as well as central nervous system effects of cocaine. This article explores the role of beta-blockers in the management of cocaine toxicity.
Damodaran
Senthilkumar
S
Department of Internal Medicine, University at Buffalo, Erie County Medical Center, 462 Grider Street, Buffalo, New York 14215, USA. sd33@buffalo.edu
D054058:Acute Coronary Syndrome / Q000139:chemically induced / Q000188:drug therapy; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects; D002227:Carbazoles / Q000494:pharmacology / Q000627:therapeutic use; D002319:Cardiovascular System / Q000187:drug effects; D000077261:Carvedilol; D003042:Cocaine / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D019970:Cocaine-Related Disorders / Q000150:complications; D006801:Humans; D011412:Propanolamines / Q000494:pharmacology / Q000627:therapeutic use
D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; D003042:Cocaine