title: Visualization of macromolecular structures.
abstract: Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools.
authors.affiliation: European Molecular Biology Laboratory, Heidelberg, Germany. sean.odonoghue@embl.de
authors.forename: Seán I
authors.initials: SI
authors.lastname: O'Donoghue
authors.forename: David S
authors.initials: DS
authors.lastname: Goodsell
authors.forename: Achilleas S
authors.initials: AS
authors.lastname: Frangakis
authors.forename: Fabrice
authors.initials: F
authors.lastname: Jossinet
authors.forename: Roman A
authors.initials: RA
authors.lastname: Laskowski
authors.forename: Michael
authors.initials: M
authors.lastname: Nilges
authors.forename: Helen R
authors.initials: HR
authors.lastname: Saibil
authors.forename: Andrea
authors.initials: A
authors.lastname: Schafferhans
authors.forename: Rebecca C
authors.initials: RC
authors.lastname: Wade
authors.forename: Eric
authors.initials: E
authors.lastname: Westhof
authors.forename: Arthur J
authors.initials: AJ
authors.lastname: Olson
mesh_terms: D018360:Crystallography, X-Ray; D007091:Image Processing, Computer-Assisted; D020407:Internet; D046911:Macromolecular Substances; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D046911:Macromolecular Substances