title: [Time trend analysis of incidence rate for nasopharyngeal carcinoma in urban Shanghai].
abstract: OBJECTIVE
  To explore the secular trend of incidence for nasopharyngeal carcinoma (NPC) in urban Shanghai during 1973 - 2005.
  
  
  METHODS
  The incidence data from the population-based cancer registries in Shanghai was used in our analysis. We calculated the crude incidence rates, age-adjusted incidence rates, truncated rates and cumulative rates of NPC. The annual percentage change (APC) was used as an estimate of the secular trend.
  
  
  RESULTS
  Over 33 years, a total of 7889 incident NPC cases in urban Shanghai were registered for 5555 males and 2334 females, respectively. The incidence of NPC had remained stable in males during the period (APC = -0.250%, P = 0.340), but a decreasing trend was observed in females with an average reduction of -1.577% (P = 0.000) per year. During the period of 1973 - 1976 to 2001 - 2005, the crude incidence rates changed from 4.56 to 6.18 and from 3.96 to 2.41 per 100 000 in males and females, and the age-adjusted rates from 4.12 to 3.96 and from 2.18 to 3.42 per 100 000 in males and females, respectively.
  
  
  CONCLUSIONS
  From 1973 to 2005, the incidence of NPC was stable in males while having a decline in females, indicating that further epidemiological study and prevention for NPC should be addressed.
authors.affiliation: School of Public Health, Fudan University, Shanghai 200032, China.
authors.forename: Wan-shui
authors.initials: WS
authors.lastname: Yang
authors.forename: Chi
authors.initials: C
authors.lastname: Yang
authors.forename: Jia-wei
authors.initials: JW
authors.lastname: Zheng
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Zhi-yuan
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Yong-bing
authors.initials: YB
authors.lastname: Xiang
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D002277:Carcinoma; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology*; D017678:Sex Distribution; D055815:Young Adult