[Effects of danhong injection on experimental atherosclerosis rabbit model and its mechanism].
OBJECTIVE
To observe the effects of Danhong injection on experimental atherosclerosis rabbits and explore its possible mechanism.


METHODS
Forty New-Zealand male rabbits were randomly divided into four groups: normal control group, high-cholesterol group, danhong injection group and aspirin group, all rabbits were administered for fourteen weeks. The plaque area of aorta in each group was determined by image analysis. The blood lipid level was tested by ELISA method, malonaldehyde (MDA) in aorta wall was analyzed with thiobarbituric acid method, the iNOS and COX-2 in aorta wall was tested with RT-PCR method.


RESULTS
There were significant difference between danhong injection group and other groups (P < 0.5), danhong injection and Aspirin decreased the TG, TC and LDL-C level in plasma of rabbit model and decreased the expression of inflammatory cytokines and the oxidative stress level in aorta wall.


CONCLUSIONS
Danhong injection can inhibit the formation of experimental atherosclerosis in rabbits, which may be related to decreasing blood lipid, plaque inflammation and oxidative stress level.
Fu
Ting-ting
TT
Guangdong Provincial People's Hospital, Guangzhou 510080, China. tien404@hotmail.com
Wang
Chang-jun
CJ
Min
Cun-yun
CY
Huang
Xu-hui
XH
D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use; D050197:Atherosclerosis / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D031187:Carthamus tinctorius / Q000737:chemistry; D002784:Cholesterol / Q000097:blood; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D007267:Injections; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D008517:Phytotherapy; D011817:Rabbits; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D014280:Triglycerides; C540581:danhong; D008315:Malondialdehyde; D002784:Cholesterol; D019001:Nitric Oxide Synthase; D001241:Aspirin