Association between respiratory and herpes viruses on pulmonary exacerbations in cystic fibrosis patients.
Respiratory viruses discovered in the 21st century and human herpes viruses (N=13) were seldom (4/50) detected in our cystic fibrosis patients although exacerbation frequency (7.75+/-2.9/a versus 4.45+/-2.1/a; p=0.03) and colonization with Aspergillus fumigatus (RR: 2.6; CI95: 1.8-3.7), Pseudomonas aeruginosa (RR: 1.84; CI95: 1.4-2.4), and Staphylococcus aureus (RR: 1.5; CI95: 1.2-1.9) including MRSA (RR: 4.6; CI95: 1.3-16.6) were associated with virus positivity. Further studies should clarify whether this finding reflects non-specific colonization (human Bocavirus) or reactivation (Epstein-Barr virus) or rather an acceleration of lung tissue inflammation.
Scheithauer
Simone
S
Department of Infection Control and Infectious Diseases, University Hospital RWTH Aachen, Germany. sscheithauer@ukaachen.de <sscheithauer@ukaachen.de>
Haase
Gerhard
G
Häusler
Martin
M
Lemmen
Sebastian
S
Ritter
Klaus
K
Kleines
Michael
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications*; D018450:Disease Progression; D005260:Female; D006566:Herpesviridae Infections / Q000150:complications*; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D056661:Human bocavirus / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010322:Parvoviridae Infections / Q000150:complications*; D019562:Viral Load; D055815:Young Adult