A new butanolide and a new secobutanolide from Litsea lii var. nunkao-tahangensis.
The chloroform-soluble portion of the leaf extract of Litsea lii var. nunkao-tahangensis was further studied and these studies led to the isolation of a new butanolide, litsealiicolide C (1), and a new secobutanolide, secoisolitsealiicolide B (2), along with seven known compounds, linderanolide B (3), isolinderanolide C (4), secolincomolide A (5), secokotomolide A (6), (+)-beta-eudesmol (7), trans-phytol (8), and (-)-matairesinol (9). Their structures were established on the basis of spectral analysis and comparison with the literature data. In addition, the cytotoxicities against MCF-7, NCI-H460, and SF-268 cancer cell lines were measured in vitro and the results demonstrated that these metabolites have no cytotoxicity against the selected tumour cells.
Cheng
Ming-Jen
MJ
Bioresource Collection and Research Center, Food Industry Research and Development Institute, Hsinchu, ROC.
Wang
Tzu-Ann
TA
Lee
Shiow-Ju
SJ
Chen
Ih-Sheng
IS
D015107:4-Butyrolactone / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D032862:Litsea / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000633:toxicity; D018515:Plant Leaves / Q000737:chemistry*
D010936:Plant Extracts; D015107:4-Butyrolactone