title: A concise synthesis of enantiopure circumdatins E, H and J.
abstract: A concise total synthesis of enantiopure circumdatins E, H and J has been developed using a reductive cyclization of chiral N-prolinoyl-2-nitrobenzamides to construct the core quinazolinone ring.
authors.affiliation: Medicinal Chemistry Department, AMRI, 26 Corporate Circle P.O. Box 15098, Albany, New York 12212, USA. Paul.Zhichkin@amriglobal.com
authors.forename: Paul E
authors.initials: PE
authors.lastname: Zhichkin
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Jin
authors.forename: Honglu
authors.initials: H
authors.lastname: Zhang
authors.forename: Lisa H
authors.initials: LH
authors.lastname: Peterson
authors.forename: Catherine
authors.initials: C
authors.lastname: Ramirez
authors.forename: Tara M
authors.initials: TM
authors.lastname: Snyder
authors.forename: Hilde S
authors.initials: HS
authors.lastname: Burton
mesh_terms: D001570:Benzodiazepinones / Q000138:chemical synthesis* / Q000737:chemistry*; D052999:Quinazolinones / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D001570:Benzodiazepinones; D052999:Quinazolinones; C549826:circumdatin E; C504253:circumdatin H; C549827:circumdatin J