Studies on novel D-ring substituted steroidal pyrazolines as potential anticancer agents.
An efficient and facile synthesis of 17-pyrazolinyl derivatives of pregnenolone and their evaluation as potential anticancer agents against various human cancer cell lines are reported. The scheme involves the transformation of the starting pregnenolone acetate into pregnenolone, conversion of pregnenolone to the corresponding benzylidine derivatives and finally the conversion of this derivative to the stable steroidal 17-pyrazoline. Various compounds 4b, 4c, 4e, 4f, 4h and 4j showed significant cytotoxic activity especially against HT-29, HCT-15, 502713 cell lines.
Banday
Abid H
AH
Department of Chemistry, Islamia College of Science and Commerce, Srinagar 190009, India. abidrrl@gmail.com
Mir
Bilal P
BP
Lone
Imtiyaz H
IH
Suri
K A
KA
Kumar
H M Sampath
HM
D000447:Aldehydes / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001597:Benzylidene Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D006801:Humans; D011284:Pregnenolone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D011720:Pyrazoles / Q000737:chemistry*
D000447:Aldehydes; D000970:Antineoplastic Agents; D001597:Benzylidene Compounds; D011720:Pyrazoles; C031280:pyrazole; D011284:Pregnenolone