title: [Physical activity and peripheral arterial obstructive disease].
abstract: Intermittent claudication (IC) is the most common clinical manifestation of atherosclerotic peripheral arterial disease. Exercise training plays a major role in treating patients with IC. Regular exercise increases functional walking capacity, reduces cardiovascular mortality and improves quality of life. This seems to be achieved by: favorable effect on cardiovascular risk factors, anti-inflammatory effect, increased collateral blood flux, improved rheology profile, endothelial function, fibrinolysis, and muscular metabolism. However, exact mechanisms underlying beneficial effect of exercise remain largely unknown. Exercise modalities will be discussed in this article.
authors.affiliation: Service d'angiologie, CHUV, 1011 Lausanne. luca.calanca@chuv.ch
authors.forename: Luca
authors.initials: L
authors.lastname: Calanca
authors.forename: Maxime
authors.initials: M
authors.lastname: Pellegrin
authors.forename: Lucia
authors.initials: L
authors.lastname: Mazzolai
mesh_terms: D001157:Arterial Occlusive Diseases / Q000145:classification / Q000534:rehabilitation*; D001162:Arteriosclerosis Obliterans / Q000534:rehabilitation; D015444:Exercise; D005342:Fibrinolysis / Q000502:physiology; D018056:Hemorheology / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000517:prevention & control; D007383:Intermittent Claudication / Q000145:classification / Q000534:rehabilitation; D007866:Leg / Q000098:blood supply*; D016491:Peripheral Vascular Diseases / Q000145:classification / Q000534:rehabilitation*; D016138:Walking