title: Testicular thecoma in an 11-year-old boy with nevoid basal-cell carcinoma syndrome (Gorlin syndrome).
abstract: We report a case of testicular thecoma in an 11-year-old Japanese boy with nevoid basal-cell carcinoma syndrome (Gorlin syndrome). He presented with left testicular swelling and underwent a radical orchiectomy on suspicion of a malignant paratesticular tumor. The tumor arose from the testis exophytically and was diagnosed as a thecoma histopathologically. Ovarian thecoma-fibroma group tumors are closely associated with Gorlin syndrome or with abnormalities in PTCH, a candidate gene for the syndrome. The occurrence of an extremely rare testicular thecoma in this case (the second in the literature) suggests that such an etiological association may also exist in the pathogenesis of testicular tumors.
authors.affiliation: Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan.
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Ueda
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kanematsu
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nishiyama
authors.forename: Koji
authors.initials: K
authors.lastname: Yoshimura
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Tohru
authors.initials: T
authors.lastname: Yorifuji
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Mikami
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kamoto
authors.forename: Osamu
authors.initials: O
authors.lastname: Ogawa
mesh_terms: D001478:Basal Cell Nevus Syndrome / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D001707:Biopsy, Needle; D002648:Child; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D009367:Neoplasm Staging; D009919:Orchiectomy / Q000379:methods; D035583:Rare Diseases; D013736:Testicular Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D013798:Thecoma / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D016896:Treatment Outcome