title: Adenocarcinomas on the rise--does it influence survival from oesophageal cancer?
abstract: OBJECTIVE
  A significant change in the occurrence of oesophageal squamous cell carcinomas (SCCs) in relation to adenocarcinomas (ACs) has been observed in the Norwegian population during the last 20 years (1988-2007). The AC incidence has increased from 5-10% to more than 50% nowadays, while the incidence of SCCs has decreased. Our goal was to evaluate if the change from SCC to AC and the increased effort to control reflux could be reflected in tumour stage, patient demographics and treatment results.
  
  
  METHODS
  We analysed clinical and pathological data from 347 patients with oesophageal AC (n = 189) and SCC (n = 158) treated at The Norwegian Radium Hospital during said period for patient- and tumour characteristics, treatment modalities and survival.
  
  
  RESULTS
  An oesophageal resection was performed in 169 of 347 patients. The median survival rate for all patients was 15 months, with a 5-year survival rate of 10%. The median survival time for operated and non-operated patients was 25 and 12 months respectively, with the corresponding 5-year survival rate of 13% and 2%. Patients with N0M0 disease operated with free resection margins presented a 5-year survival rate of 28%.
  
  
  CONCLUSIONS
  The change from SCC to AC and the ensuing considerable efforts made in surveillance and treatment of AC did not lead to improved long time survival for our patients.
authors.affiliation: Department of Surgical Oncology, The Norwegian Radium Hospital, Montebello, Oslo, Faculty of Medicine, University of Oslo, Oslo, Norway. mariuszg@online.no
authors.forename: M A
authors.initials: MA
authors.lastname: Goscinski
authors.forename: S G
authors.initials: SG
authors.lastname: Larsen
authors.forename: T
authors.initials: T
authors.lastname: Warloe
authors.forename: S
authors.initials: S
authors.lastname: Stoldt
authors.forename: J M
authors.initials: JM
authors.lastname: Nesland
authors.forename: Z H
authors.initials: ZH
authors.lastname: Suo
authors.forename: K-E
authors.initials: KE
authors.lastname: Giercksky
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000473:pathology / Q000628:therapy*; D015331:Cohort Studies; D004938:Esophageal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000628:therapy*; D005260:Female; D005764:Gastroesophageal Reflux / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome