Role of ischemic preconditioning in liver transplant: a review of literature.
Interruption of blood flow and subsequent organ reperfusion lead to significant tissue damage. This well-studied phenomenon is recognized as ischemia/reperfusion injury. Ischemic preconditioning refers to a mechanism in which a prior, short, ischemic period induces some protection against a subsequent prolonged ischemic and reperfusion damage. The mechanisms involved in ischemic preconditioning and its applications for clinical and basic research are discussed in this paper.
Macedo
Francisco Igor Bulcão
FI
Department of Surgery and Liver Transplantation, University of Pernambuco School of Medicine, Oswaldo Cruz University Hospital, Recife, Brazil. igormacedo1@hotmail.com
Miranda
Luiz Eduardo Correia
LE
D000818:Animals; D006801:Humans; D019194:Ischemic Preconditioning / Q000379:methods*; D016031:Liver Transplantation / Q000502:physiology*; D023421:Models, Animal; D018384:Oxidative Stress / Q000502:physiology; D015427:Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control*