Oligooxopiperazines as nonpeptidic alpha-helix mimetics.
A new class of nonpeptidic alpha-helix mimetics derived from alpha-amino acids and featuring chiral backbones is described. NMR and circular dichroism spectroscopies, in combination with molecular modeling studies, provide compelling evidence that oligooxopiperazine dimers adopt stable conformations that reproduce the arrangement of i, i+4, and i+7 residues on an alpha-helix.
Tosovská
Petra
P
Department of Chemistry, New York University, 100 Washington Square East, New York, New York 10003, USA.
Arora
Paramjit S
PS
D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D010879:Piperazines / Q000138:chemical synthesis* / Q000737:chemistry
D010879:Piperazines