title: Overweight and obesity negatively affect the outcomes of ovarian stimulation and in vitro fertilisation: a cohort study of 2628 Chinese women.
abstract: OBJECTIVE
  To explore the effects of overweight and obesity on the outcomes of in vitro fertilisation (IVF) in Chinese infertile patients.
  
  
  METHODS
  A retrospective cohort study was carried out in 2222 normal weight (18.5 <or= BMI < 25), 379 overweight (25 <or= BMI < 30) and 27 obese (BMI >or= 30) women who underwent their first IVF cycles between 2002 and 2008. Cycle characteristics and IVF outcomes were analysed.
  
  
  RESULTS
  Obese women required significantly higher dose of rFSH (3272 IU vs. 2587 IU, p < 0.001) and days of stimulation (11.89 +/- 4.57 vs. 10.42 +/- 2.03, p < 0.001), but exhibited less oocytes retrieved and significantly lower fertilisation rate (54.1% vs. 61.1%, p < 0.001) than normal weight women. Compared with normal weight women, overweight women displayed significantly less oocytes retrieved (12.98 +/- 6.91 vs. 14.49 +/- 7.96, p < 0.001), lower fertilisation rate (60.8 +/- 23.3 vs. 61.1 +/- 23.0, p < 0.001), less cleavaged embryos (7.55 +/- 4.86 vs. 8.67 +/- 5.90, p < 0.001), less high-grade embryos (4.65 +/- 3.96 vs. 5.59 +/- 4.81, p < 0.001) and cryopreserved embryos (4.44 +/- 4.55 vs. 5.49 +/- 5.55, p < 0.001). All parameters of pregnancy outcomes, including pregnancy rate, miscarriage rate and live birth rate, were comparable among three groups.
  
  
  CONCLUSIONS
  Overweight and obesity are related with impared ovarian response, and negatively affect the outcomes of IVF.
authors.affiliation: Department of Reproductive Endocrinology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Zhang
authors.forename: Yimin
authors.initials: Y
authors.lastname: Zhu
authors.forename: Huijuan
authors.initials: H
authors.lastname: Gao
authors.forename: Biao
authors.initials: B
authors.lastname: Zhou
authors.forename: Runju
authors.initials: R
authors.lastname: Zhang
authors.forename: Tingting
authors.initials: T
authors.lastname: Wang
authors.forename: Guolian
authors.initials: G
authors.lastname: Ding
authors.forename: Fan
authors.initials: F
authors.lastname: Qu
authors.forename: Hefeng
authors.initials: H
authors.lastname: Huang
authors.forename: Xiue
authors.initials: X
authors.lastname: Lu
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002681:China; D015331:Cohort Studies; D015925:Cryopreservation; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D006801:Humans; D007246:Infertility / Q000628:therapy*; D009765:Obesity / Q000150:complications*; D009865:Oocytes; D050177:Overweight / Q000150:complications*; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D011256:Pregnancy Outcome; D011994:Recombinant Proteins / Q000008:administration & dosage; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic; D020858:Tissue and Organ Harvesting; D016896:Treatment Outcome; D017329:Triptorelin Pamoate / Q000008:administration & dosage
chemical_list: D011994:Recombinant Proteins; D017329:Triptorelin Pamoate; D005640:Follicle Stimulating Hormone