title: The value of C-reactive protein determination in patients with renal colic to decide urgent urinary diversion.
abstract: OBJECTIVE
  To analyze whether C-reactive protein (CRP) predicts the need for urgent urinary diversion in patients with renal colic and urolithiasis. CRP may help in the differential diagnosis of complicated hydronephrosis.
  
  
  METHODS
  Prospective study done on 110 consecutive patients with renal colic secondary to upper urinary tract calculi admitted in the emergency room. Clinical and analytical data were collected. Criteria for emergency drainage had been established in advance, based on the risk of sepsis, renal failure, persistence of pain, and findings on computed tomography scan. CRP was blindly determined using immunoturbidimetric assay on the Integra 700 analyzer. Statistical analysis included Mann-Whitney test, Cox multivariate analysis, and receiver operating characteristic curves, to determine optimum cut-off points to decide drainage based on laboratory data.
  
  
  RESULTS
  Mean CRP value was 47.6 mg/L (CI, 31.4-63.8), 139.6 mg/L (CI, 13-183.1) in 29 patients treated with diversion and 14.67 mg/L (CI, 6.7-22.5) in the control group (P <.001). Age, sex, rate of patients with hypertension, history of cardiovascular disease, leukocyte total count, and serum creatinine differed between groups (P <.05). Regression analysis revealed CRP (P <.0001) and age (P = .0001) were predictive of urinary diversion. Receiver operating characteristic analysis revealed 68.4% area under the curve for creatinine, 68.8% for leukocytosis, and 86.8% for CRP. A cut-off point for CRP of 28 mg/L achieved optimum sensitivity (75.8%) and specificity (88.9%) for determining the decision for drainage.
  
  
  CONCLUSIONS
  Determination of CRP in patients with renal colic due to urolithiasis provides an objective and useful parameter for deciding placement of urinary stent, which is even more valuable than leukocytosis or seric creatinine level.
authors.affiliation: Department of Urology, Fundación para la Investigación Biomédica, Hospital Universitario de Getafe, Universidad Europea de Madrid, Madrid, Spain. jangulo@futurnet.es
authors.forename: Javier C
authors.initials: JC
authors.lastname: Angulo
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Gaspar
authors.forename: Nuria
authors.initials: N
authors.lastname: Rodríguez
authors.forename: Ana
authors.initials: A
authors.lastname: García-Tello
authors.forename: Gina
authors.initials: G
authors.lastname: Torres
authors.forename: Carlos
authors.initials: C
authors.lastname: Núñez
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis*; D003085:Colic / Q000097:blood* / Q000209:etiology / Q000601:surgery*; D004322:Drainage; D004638:Emergency Treatment; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000150:complications / Q000601:surgery; D007674:Kidney Diseases / Q000097:blood* / Q000209:etiology / Q000601:surgery*; D007682:Kidney Pelvis; D008297:Male; D008875:Middle Aged; D009403:Nephrostomy, Percutaneous; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012720:Severity of Illness Index; D015607:Stents; D014514:Ureteral Calculi / Q000150:complications / Q000601:surgery; D014547:Urinary Diversion
chemical_list: D002097:C-Reactive Protein