title: Adiponectin is associated with abnormal lipid profile and coronary microvascular dysfunction in patients with dilated cardiomyopathy without overt heart failure.
abstract: Reduced plasma adiponectin has been associated with abnormal lipid profile, reduced left ventricle (LV) function, and the extent of coronary atherosclerosis in coronary artery disease. The aim of this study was to assess these relationships in patients with dilated cardiomyopathy (DCM) without overt heart failure. Plasma adiponectin was measured in 55 DCM patients (age, 59 ± 12 years; male, 36; body mass index [BMI], 26.9 ± 0.49 kg/m²; LV ejection fraction, 39.8% ± 1.3%; New York Heart Association class I-II) and in 40 age- and BMI-matched healthy controls. In a subset of 25 patients, myocardial blood flow (MBF) was measured at rest and during intravenous dipyridamole (0.56 mg/kg in 4 minutes) by positron emission tomography and ¹³N-ammonia as a flow tracer. Adiponectin was 6.6 ± 0.34 μg/mL in controls and 10.9 ± 0.85 μg/mL in DCM patients (P < .001), where it was related inversely with BMI (P = .009) and directly with brain natriuretic peptide (P = .017), high-density lipoprotein (HDL) cholesterol (P = .002), and MBF dipyridamole (P = .020). Adiponectin lesser than median value in patients was associated with higher total to HDL cholesterol ratio (4.8 ± 0.24 vs 3.9 ± 0.18, P = .009) and lower MBF reserve (1.76 ± 0.16 vs 2.43 ± 0.19, P = .01). These results could suggest that down-regulation of the adiponectin levels and reduced HDL cholesterol have a key role in causing impaired coronary function and myocardial perfusion in DCM.
authors.affiliation: Research National Council (CNR) Institute of Clinical Physiology-Laboratory of Cardiovascular Biochemistry, Pisa 56124, Italy. danielag@ifc.cnr.it
authors.forename: Daniela
authors.initials: D
authors.lastname: Giannessi
authors.forename: Chiara
authors.initials: C
authors.lastname: Caselli
authors.forename: Silvia
authors.initials: S
authors.lastname: Del Ry
authors.forename: Maristella
authors.initials: M
authors.lastname: Maltinti
authors.forename: Silvia
authors.initials: S
authors.lastname: Pardini
authors.forename: Stefano
authors.initials: S
authors.lastname: Turchi
authors.forename: Manuela
authors.initials: M
authors.lastname: Cabiati
authors.forename: Tiziana
authors.initials: T
authors.lastname: Sampietro
authors.forename: Nader
authors.initials: N
authors.lastname: Abraham
authors.forename: Antonio
authors.initials: A
authors.lastname: L'abbate
authors.forename: Danilo
authors.initials: D
authors.lastname: Neglia
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000502:physiology; D000641:Ammonia; D015992:Body Mass Index; D002311:Cardiomyopathy, Dilated / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008076:Cholesterol, HDL / Q000097:blood; D015331:Cohort Studies; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004176:Dipyridamole / Q000097:blood; D005260:Female; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids; D008297:Male; D055806:Microvessels / Q000000981:diagnostic imaging / Q000503:physiopathology*; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D009590:Nitrogen Radioisotopes; D049268:Positron-Emission Tomography; D013318:Stroke Volume / Q000502:physiology
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D008076:Cholesterol, HDL; D008055:Lipids; D009590:Nitrogen Radioisotopes; D020097:Natriuretic Peptide, Brain; D004176:Dipyridamole; D000641:Ammonia