The measurement of ecstasy in human hair by triple phase directly suspended droplet microextraction prior to HPLC-DAD analysis.
New pre-concentration technique, triple phase suspended droplet microextraction (SD-LPME) and liquid chromatography-photodiode array detection was applied to determine ecstasy, MDMA (3,4-methylendioxy-N-methylamphetamine) in hair samples. In this research MDMA in hair was digested and after treatment extracted. The effective parameters were investigated and method was evaluated. Under the optimal conditions, the MDMA was enriched by factor 98.11. Linearity (r=0.9921), was obtained in the range of 10-15,000 ng mL(-1) and detection limit was 0.1 ng mL(-1).
Es'haghi
Zarrin
Z
Department of Chemistry, Payame Noor University, Mashhad, Iran. zarrin eshaghi@yahoo.com
Mohtaji
Maryam
M
Hasanzade-Meidani
Mahin
M
Masrournia
Mahboubeh
M
D000818:Animals; D005591:Chemical Fractionation / Q000379:methods*; D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods*; D006197:Hair / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D051379:Mice; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000032:analysis*; D009930:Organic Chemicals / Q000737:chemistry; D044367:Phase Transition; D012997:Solvents / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry / Q000494:pharmacology; D013535:Suspensions; D013997:Time Factors
D009930:Organic Chemicals; D012997:Solvents; D013501:Surface-Active Agents; D013535:Suspensions; D018817:N-Methyl-3,4-methylenedioxyamphetamine