title: [Determination of cefixime blood plasma levels by HPLC].
abstract: For comparative study of the pharmacokinetics of Cemidexor (capsules of 100 mg) and Suprax (capsules of 400 mg), a method of HPLC with quantitative determination of cefixime (the active substance in the drugs) in the blood plasma of patients with UV detection was developed. The data teproducibility with an account of the admissibility criterion was observed within the interval of all the concentrations (0.06-10 mcg/ml). The accuracy and correctness of the method also corresponded to the admissibility criteria. The lower limit of the quantitative determimation of the cefexime blood plasma levels was 0.06 mcg/ml. The pharmacokinetics was studied with the open crossed randomized method. The results were used for calculation of the pharmacokinetic parameters required for estimation of the bioequivalence of the drugs. The statistical analysis of the pharmacokinetic parameters showed that Cemidoxor and Suprax were bioequivalent.
authors.forename: V V
authors.initials: VV
authors.lastname: Pisarev
authors.forename: K V
authors.initials: KV
authors.lastname: Zaĭtseva
authors.forename: L B
authors.initials: LB
authors.lastname: Smirnova
authors.forename: V G
authors.initials: VG
authors.lastname: Belolipetskaia
authors.forename: D A
authors.initials: DA
authors.lastname: Kibal'chich
authors.forename: I E
authors.initials: IE
authors.lastname: Koltunov
mesh_terms: D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000097:blood* / Q000493:pharmacokinetics; D002214:Capsules; D020682:Cefixime / Q000097:blood* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D006801:Humans; D012680:Sensitivity and Specificity; D014466:Ultraviolet Rays
chemical_list: D000900:Anti-Bacterial Agents; D002214:Capsules; D020682:Cefixime