title: Speciation analysis of Sb(III) and Sb(V) in antileishmaniotic drug using Dowex 1 x 4 resin from hydrochloric acid solution.
abstract: A new and simple method for the direct and simultaneous determination of Sb(III) and Sb(V) in meglumine antimoniate, the first-choice drug for leishmaniasis treatment, was developed. Speciation analysis was carried out using the quantitative separation of inorganic trivalent and pentavalent antimony on Dowex 1 x 4 resin from 1.5 mol l(-1) hydrochloric acid solution. The inductively coupled plasma optical emission spectrometry (ICP-OES) was used for determination of antimony. The interfering effects of As, Bi, Cd, Cu, Mn, Pb and Zn were examined and only Bi was found to be a significant interferent. The liberation of Sb(V) and Sb(III) from organoantimonial compounds without changing of oxidation state was carried out by means of 1.5 mol l(-1) hydrochloric acid solution. The spike recovery values obtained for Sb(III) in pharmaceutical sample varied from 92 to 100%. The method was successfully applied for the direct determination of antimony(III) and of antimony(V) in meglumine antimoniate.
authors.affiliation: Chemistry Department, Analytical Chemistry Division, Wroclaw University of Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.
authors.forename: L
authors.initials: L
authors.lastname: Łukaszczyk
authors.forename: W
authors.initials: W
authors.lastname: Zyrnicki
mesh_terms: D000837:Anion Exchange Resins; D000965:Antimony / Q000032:analysis*; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000494:pharmacology; D006851:Hydrochloric Acid / Q000737:chemistry*; D007891:Leishmania / Q000187:drug effects*; D012117:Resins, Synthetic; D012996:Solutions; D013054:Spectrophotometry, Atomic / Q000379:methods
chemical_list: D000837:Anion Exchange Resins; D000981:Antiprotozoal Agents; D012117:Resins, Synthetic; D012996:Solutions; C027972:Dowex; D000965:Antimony; D006851:Hydrochloric Acid