Targeting early infection to prevent HIV-1 mucosal transmission.
Measures to prevent sexual mucosal transmission of human immunodeficiency virus (HIV)-1 are urgently needed to curb the growth of the acquired immunodeficiency syndrome (AIDS) pandemic and ultimately bring it to an end. Studies in animal models and acute HIV-1 infection reviewed here reveal potential viral vulnerabilities at the mucosal portal of entry in the earliest stages of infection that might be most effectively targeted by vaccines and microbicides, thereby preventing acquisition and averting systemic infection, CD4 T-cell depletion and pathologies that otherwise rapidly ensue.
Haase
Ashley T
AT
Department of Microbiology, University of Minnesota, Minnesota 55455, USA. haase001@umn.edu
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000517:prevention & control* / Q000635:transmission; D000818:Animals; D004195:Disease Models, Animal; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D018928:Immunity, Mucosal; D009092:Mucous Membrane / Q000276:immunology* / Q000821:virology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000635:transmission; D015302:Simian Immunodeficiency Virus / Q000276:immunology; D013997:Time Factors