title: EUS-guided pancreatic cyst brushing: a comparative study in a tertiary referral centre.
abstract: BACKGROUND
  Fluid analysis obtained by EUS guided FNA is used to aid in diagnosis and management of cystic lesions in the pancreas. Complementing fluid aspiration with brushing of cyst wall may increase the cellular yield.
  
  
  OBJECTIVE
  To compare cellular yield of pancreatic cyst FNA with and without wall brushing.
  
  
  METHODS
  Comparative study.
  
  
  METHODS
  Tertiary referral centre.
  
  
  METHODS
  Fifty-one patients with cystic pancreatic lesions referred for EUS-guided aspiration/sampling were included (median age 69 years; interquartile range: 49-77 years).
  
  
  METHODS
  Comparing adequacy of cellular yield between EUS-guided aspiration alone vs. EUS-guided aspiration and cyst wall brushing.
  
  
  METHODS
  EUS-guided FNA and/or wall brushing (aspiration only: No. 27; brushing: No. 24).
  
  
  RESULTS
  There was no significant difference in age (P=0.496) cyst size (P=0.084) or cyst location (P=0.227) between groups. Overall 29.5%; (15/51) of samples were acellular/insufficient with no significant difference between the two groups (22.2% in the aspiration only group vs. 37.5% in the brushing group; P=0.356). The remaining samples were adequate for cytological evaluation (77.8% vs. 62.5%; aspiration only vs. brushing groups). Seventeen cases were neoplastic (8 benign, 9 malignant). The diagnostic accuracy was 61.9% and 55.0% in aspiration only and brushing groups, respectively. Two out of 4 (50.0%) patents were diagnosed as having cancer in the brushings group compared to 1/5 (20.0%) in the FNA only group (P=0.524).
  
  
  CONCLUSIONS
  Non-randomised series.
  
  
  CONCLUSIONS
  The cellular yield was similar in FNA and brushing group. Greater proportion of patients with malignant cystic pancreatic lesions diagnosed by EUS sampling was in the brushing group, but this did not reach statistical significance.
authors.affiliation: Biomedical Research Unit, Nottingham Digestive Diseases Centre and Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom.
authors.forename: Titus
authors.initials: T
authors.lastname: Thomas
authors.forename: James
authors.initials: J
authors.lastname: Bebb
authors.forename: Jayan
authors.initials: J
authors.lastname: Mannath
authors.forename: Krish
authors.initials: K
authors.lastname: Ragunath
authors.forename: Phillip V
authors.initials: PV
authors.lastname: Kaye
authors.forename: Guruprasad P
authors.initials: GP
authors.lastname: Aithal
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy / Q000379:methods; D002277:Carcinoma / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D003937:Diagnosis, Differential; D016145:Endoscopy, Digestive System / Q000379:methods*; D019160:Endosonography / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D010181:Pancreatic Cyst / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology*; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D012017:Referral and Consultation; D012680:Sensitivity and Specificity; D018084:Ultrasonography, Interventional / Q000379:methods