title: Quantitative analysis of argyrophilic nuclear organizer regions in giant cell lesions of jaws.
abstract: BACKGROUND
  Giant cell lesions of the jaws are considerably similar according to histopathologic characteristics yet show different clinical behaviors. These lesions include central giant cell granuloma (CGCG), aneurysmal bone cyst, Cherubism, and Brown tumor associated with hyperparathyroidism. The present study aimed to investigate AgNORs count in these lesions as a proliferative marker and to determine whether it can be used to discriminate between them or not.
  
  
  METHODS
  Forty-one cases of giant cell lesions of jaws were retrived from Oral Pathology Department (1987-2007). They included 21 cases of CGCG, eight cases of aneurysmal bone cyst (ABC), six cases of Cherubism, six cases of Brown tumor. The mean AgNORs count was calculated for all cases. To compare mean AgNORs in groups of lesions, ANOVA test was performed.
  
  
  RESULTS
  Mean AgNOR counts were: (0/85 +/- 0/29) in CGCG, (0/76 +/- 0/32) in ABC (0/87 +/- 0/10) in Cherubism and (0/82 +/- 0/16) in Brown tumor. A significant difference was not observed in AgNOR counts among these groups of lesions.
  
  
  CONCLUSIONS
  Jaws giant cell containing lesions have no acceptable differences in mean AgNORs.
authors.affiliation: Oral and Maxillofacial Pathology Department, Islamic Azad University Dental School, Tehran, Iran. Donia1351@yahoo.com
authors.forename: Donia
authors.initials: D
authors.lastname: Sadri
authors.forename: Massoud
authors.initials: M
authors.lastname: Hejazi
authors.forename: Jahanfar
authors.initials: J
authors.lastname: Jahanbani
authors.forename: Aghdas
authors.initials: A
authors.lastname: Forouzandeh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D034961:Antigens, Nuclear / Q000032:analysis; D017824:Bone Cysts, Aneurysmal / Q000473:pathology; D002636:Cherubism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005260:Female; D015726:Giant Cells / Q000473:pathology*; D006101:Granuloma, Giant Cell / Q000473:pathology; D006801:Humans; D007571:Jaw Diseases / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009697:Nucleolus Organizer Region / Q000737:chemistry / Q000473:pathology*; D010002:Osteitis Fibrosa Cystica / Q000473:pathology; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D034961:Antigens, Nuclear; C051963:nucleolar organizer region associated proteins