The frequency of fentanyl-induced cough in children and its effects on tracheal intubation.
OBJECTIVE
To determine if fentanyl-induced cough was dose-dependent in children and whether it could affect tracheal intubation.


METHODS
Prospective, randomized, double-blinded study.


METHODS
Operating room of a university-affiliated hospital.


METHODS
160 ASA physical status I pediatric patients, aged two to 14 years, scheduled for elective surgery during general anesthesia and requiring orotracheal intubation.


METHODS
Patients were divided into two groups. Group 1 patients were given fentanyl at a dosage of one microg/kg; Group 2 patients received two microg/kg of fentanyl. Induction of anesthesia was conducted immediately following cough cessation or one minute after the end of injection with propofol 2.5 mg/kg. At loss of eyelash reflex, rocuronium 0.6 mg/kg was given intravenously (IV). Two minutes later, tracheal intubation was started.


METHODS
Onset and degree of cough and intubating conditions were observed and recorded.


RESULTS
No statistically significant differences in frequency of coughing or in intubating conditions between the two groups were noted. Cough severity in Group 1 was statistically lower than that of Group 2 (P < 0.05). Onset of cough in Group 2 (12.2 +/- 3.4 sec) was statistically shorter than in Group 1 (16.9 +/- 7.6 sec, P < 0.05).


CONCLUSIONS
Fentanyl at doses of one and two microg/kg may induce coughing in pediatric patients.
Han
Jong In
JI
Department of Anesthesiology and Pain Medicine, School of Medicine, Ewha Womans University, Seoul 158-710, South Korea. hanji@ewha.ac.kr <hanji@ewha.ac.kr>
Lee
Heeseung
H
Kim
Chi Hyo
CH
Lee
Guie Yong
GY
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003371:Cough / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007442:Intubation, Intratracheal; D008297:Male; D009294:Narcotics / Q000008:administration & dosage / Q000009:adverse effects*; D011446:Prospective Studies; D016896:Treatment Outcome
D009294:Narcotics; D005283:Fentanyl