title: Perfusion index variations in clinically and hemodynamically stable preterm newborns in the first week of life.
abstract: BACKGROUND
  The perfusion index, derived from the pulse oximeter signal, seems to be an accurate predictor for high illness severity in newborns. The aim of this study was to determine the perfusion index values of clinically and hemodynamically stable preterm newborns in the first week of life.
  
  
  METHODS
  Perfusion index recordings were performed on the first, third and seventh day of life on 30 preterm newborns. Their state of health was assessed according to clinical and behaviour evaluation and to the Score for Neonatal Acute Physiology.
  
  
  RESULTS
  The median(interquartile range) perfusion index values were 0.9(0.6) on the first, 1.2(1.0) on the third, and 1.3(0.9) on the seventh day, with a significant increase between the first and the third day.
  
  
  CONCLUSIONS
  Perfusion index proved to be an easily applicable, non-invasive method for monitoring early postnatal changes in peripheral perfusion. Its trend during the first week of life suggests that its clinical application should take age into account. Further studies are needed to obtain reference perfusion index values from a larger sample of preterm newborns, to identify specific gestational age-related cut-off values for illness and to test the role of perfusion index in monitoring critically ill neonates.
authors.affiliation: Neonatal Care Unit, Regina Margherita Children's Hospital, Department of Pediatrics, University of Turin, Italy. francesco.cresi@unito.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Cresi
authors.forename: Emanuela
authors.initials: E
authors.lastname: Pelle
authors.forename: Roberto
authors.initials: R
authors.lastname: Calabrese
authors.forename: Luciana
authors.initials: L
authors.lastname: Costa
authors.forename: Daniela
authors.initials: D
authors.lastname: Farinasso
authors.forename: Leandra
authors.initials: L
authors.lastname: Silvestro
mesh_terms: D005500:Follow-Up Studies; D005865:Gestational Age; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D010092:Oximetry; D011379:Prognosis; D012189:Retrospective Studies