Thirty years of heme peroxidase structural biology.
The following is a brief review of peroxidase structural biology since the initial structure determination of cytochrome c peroxidase (CCP) 30 years ago. An emphasis will be placed on what CCP has taught us about peroxidase mechanisms, especially Compound I formation and electron transfer.
Poulos
Thomas L
TL
Departments of Molecular Biology & Biochemistry, Chemistry, and Pharmaceutical Sciences, University of California-Irvine, Irvine, CA 92697-3900, USA. poulos@uci.edu
D000818:Animals; D018360:Crystallography, X-Ray; D003578:Cytochrome-c Peroxidase / Q000737:chemistry / Q000378:metabolism; D004579:Electron Transport; D006801:Humans; D008958:Models, Molecular; D010544:Peroxidases / Q000737:chemistry* / Q000378:metabolism*; D011487:Protein Conformation; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000378:metabolism
D029701:Saccharomyces cerevisiae Proteins; D010544:Peroxidases; D003578:Cytochrome-c Peroxidase