title: Transient global amnesia as the presenting feature of heparin-induced thrombocytopenia.
abstract: A 57-year-old man developed transient global amnesia within an hour of bolus unfractionated heparin administration on day 4 post-mitral valve replacement. Both immunoglobulin G-specific enzyme-linked immunosorbent assay and serotonin release assay were strongly positive for the antibodies that cause heparin-induced thrombocytopenia. The patient's cognitive functions returned to normal following discontinuation of unfractionated heparin and warfarin and commencement of lepirudin infusion.
authors.affiliation: Department of Cardiology, Royal Infirmary of Edinburgh, Scotland, United Kingdom.
authors.forename: Chun Huat
authors.initials: CH
authors.lastname: Teh
authors.forename: Martyn N
authors.initials: MN
authors.lastname: Robertson
authors.forename: Theodore E
authors.initials: TE
authors.lastname: Warkentin
authors.forename: Peter A
authors.initials: PA
authors.lastname: Henriksen
authors.forename: Edward T
authors.initials: ET
authors.lastname: Brackenbury
authors.forename: Julia A M
authors.initials: JA
authors.lastname: Anderson
mesh_terms: D020236:Amnesia, Transient Global / Q000139:chemically induced / Q000175:diagnosis*; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D019918:Heart Valve Prosthesis Implantation; D006493:Heparin / Q000009:adverse effects*; D006629:Hirudins; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000473:pathology; D011994:Recombinant Proteins / Q000627:therapeutic use; D013921:Thrombocytopenia / Q000139:chemically induced / Q000150:complications*; D013997:Time Factors; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D000925:Anticoagulants; D006629:Hirudins; D011994:Recombinant Proteins; D014859:Warfarin; D006493:Heparin; C083544:lepirudin