title: Average adherence to boosted protease inhibitor therapy, rather than the pattern of missed doses, as a predictor of HIV RNA replication.
abstract: Consecutive missed doses may differentially impact the efficacy of antiretroviral therapy associated with the use of a nonnucleoside reverse-transcriptase inhibitor (NNRTI) and a ritonavir-boosted protease inhibitor (PI). In a cohort of 72 subjects receiving a boosted PI, average adherence to dosage was a better predictor of human immunodeficiency virus (HIV) replication than was the duration or frequency of treatment interruption. In contrast with an NNRTI, consecutive missed doses of a boosted PI did not emerge as a major risk factor for HIV replication.
authors.affiliation: Department of Clinical Research and Biostatistics, Côte de Nacre University Hospital, Caen F-14033, France.
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Parienti
authors.forename: Kathleen
authors.initials: K
authors.lastname: Ragland
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lucht
authors.forename: Arnaud
authors.initials: A
authors.lastname: de la Blanchardière
authors.forename: Sylvie
authors.initials: S
authors.lastname: Dargère
authors.forename: Yazdan
authors.initials: Y
authors.lastname: Yazdanpanah
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Dutheil
authors.forename: Philippe
authors.initials: P
authors.lastname: Perré
authors.forename: Renaud
authors.initials: R
authors.lastname: Verdon
authors.forename: David R
authors.initials: DR
authors.lastname: Bangsberg
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000821:virology*; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood*; D019562:Viral Load; D016903:Drug Monitoring
chemical_list: D019380:Anti-HIV Agents; D017320:HIV Protease Inhibitors; D012367:RNA, Viral