title: The interphase microtubule aster is a determinant of asymmetric division orientation in Drosophila neuroblasts.
abstract: The mechanisms that maintain the orientation of cortical polarity and asymmetric division unchanged in consecutive mitoses in Drosophila melanogaster neuroblasts (NBs) are unknown. By studying the effect of transient microtubule depolymerization and centrosome mutant conditions, we have found that such orientation memory requires both the centrosome-organized interphase aster and centrosome-independent functions. We have also found that the span of such memory is limited to the last mitosis. Furthermore, the orientation of the NB axis of polarity can be reset to any angle with respect to the surrounding tissue and is, therefore, cell autonomous.
authors.affiliation: Cell Division Group, Institute for Research in Biomedicine Barcelona, 08028 Barcelona, Spain.
authors.forename: Jens
authors.initials: J
authors.lastname: Januschke
authors.forename: Cayetano
authors.initials: C
authors.lastname: Gonzalez
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D002455:Cell Division / Q000502:physiology*; D016764:Cell Polarity; D002478:Cells, Cultured; D002502:Centrioles / Q000378:metabolism / Q000648:ultrastructure; D003703:Demecolcine / Q000378:metabolism; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000166:cytology*; D007814:Larva / Q000166:cytology / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism* / Q000648:ultrastructure; D009154:Mutation; D009474:Neurons / Q000166:cytology / Q000502:physiology; D008941:Spindle Apparatus / Q000378:metabolism* / Q000648:ultrastructure; D050257:Tubulin Modulators / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; D050257:Tubulin Modulators; D003703:Demecolcine