Inflammasomes as microbial sensors.
Members of the Nod-like receptor family and the adaptor ASC assemble into multiprotein platforms, termed inflammasomes, to mediate the activation of caspase-1 and subsequent secretion of IL-1beta and IL-18. Recent studies have identified microbial and endogenous molecules as well as possible mechanisms involved in inflammasome activation.
Franchi
Luigi
L
University of Michigan Medical School, Department of Pathology and Comprehensive Cancer Center, Ann Arbor, MI 48109, USA.
Muñoz-Planillo
Raul
R
Reimer
Thornik
T
Eigenbrod
Tatjana
T
Núñez
Gabriel
G
D000818:Animals; D017209:Apoptosis / Q000276:immunology; D001424:Bacterial Infections / Q000276:immunology*; D053468:CARD Signaling Adaptor Proteins; D003598:Cytoskeletal Proteins / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000382:microbiology*; D053583:Interleukin-1beta / Q000276:immunology; D046912:Multiprotein Complexes / Q000276:immunology*; D009181:Mycoses / Q000276:immunology*; D053472:Nod Signaling Adaptor Proteins / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology*
D053468:CARD Signaling Adaptor Proteins; D003598:Cytoskeletal Proteins; D053583:Interleukin-1beta; D046912:Multiprotein Complexes; D053472:Nod Signaling Adaptor Proteins; C402202:PYCARD protein, human