Oseltamivir-resistant 2009-2010 pandemic influenza A (H1N1) in an immunocompromised patient.
Although neuraminidase inhibitors are active against most 2009-2010 pandemic influenza A (H1N1) swine-origin strains, sporadic cases of oseltamivir resistance have been described. Since April 2009, 54 cases of oseltamivir-resistant H1N1 swine-origin have been reported in the USA (http://www.cdc.gov/flu/weekly/; accessed 1 February 2010). Approximately 1.4% of tested isolates are oseltamivir resistant. We report a patient with an underlying hematological malignancy who was hospitalized with influenza A (H1N1) swine-origin and whose strain developed oseltamivir resistance during therapy.
Chan
P A
PA
Division of Infection Disease, Department of Medicine, Alpert Medical School of Brown University, Providence, RI 02903, USA. pchan@lifespan.org
Connell
N T
NT
Gabonay
A M
AM
Westley
B
B
Larkin
J M
JM
LaRosa
S P
SP
Chapin
K
K
Mermel
L
L
D000328:Adult; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D024882:Drug Resistance, Viral; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D016867:Immunocompromised Host; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000302:isolation & purification; D007251:Influenza, Human / Q000821:virology*; D053139:Oseltamivir / Q000494:pharmacology* / Q000627:therapeutic use; D014481:United States
D000998:Antiviral Agents; D053139:Oseltamivir