title: [Extracorporeal lithotripsy in children - the efficacy and long-term evaluation of renal parenchyma damage by DMSA-99mTc scintigraphy].
abstract: OBJECTIVE
  To determine the effectiveness of extracorporeal shock-wave lithotripsy (ESWL) and possible deleterious effects on renal parenchyma of children subjected to treatment of renal lithiasis, using renal scintigraphy with 99mTc dimercapto-succunic acid (DMSA).
  
  
  METHODS
  From January 2004 to November 2007, 18 children (age 3-10 years) underwent ESWL (Philips-Dornier) for kidney urolithiasis. All patients underwent preoperative evaluation, including physical examination, urine culture, image exams and renal scintigraphy with Tc99-DMSA. Evaluation after treatment consisted of a clinical examination, blood pressure measurement, urine culture, renal ultrasound and Tc99-DMSA, repeated at 3, 6 and 12 months, which were compared to the scans obtained before ESWL to determine possible morphological or functional changes.
  
  
  RESULTS
  Success in the stones fragmentation was achieved in all cases - in 9 patients (50%) with one session of ESWL, in 6 (33%) with two sessions and in 3 patients (17%) with 3 sessions of ESWL. Only one patient (5%), after three sessions of ESWL and 6 months of follow-up showed change in size of right kidney with a decrease in tubular function, without hypertension or other major changes. In the other cases, there was absence of hypertension up to 12 months of follow-up, absence of renal hematomas detected by ultrasound or significant renal scars in scintigraphic examinations.
  
  
  CONCLUSIONS
  ESWL is effective and safe for treating renal lithiasis in children. Renal parenchyma lesions may occur early after treatment, but these lesions are transients and resolve spontaneously in virtually all cases; generally, there are no irreversible renal lesions associated with ESWL, even after the follow-up period with clinical examination, ultrasound examination and 99mTc-DMSA scintigraphy.
authors.affiliation: Servicio de Urología, Universidad Estatal de Campinas, Unicamp, Brasil. reisleo@unicamp.br
authors.forename: L O
authors.initials: LO
authors.lastname: Reis
authors.forename: E L
authors.initials: EL
authors.lastname: Zani
authors.forename: O
authors.initials: O
authors.lastname: Ikari
authors.forename: A
authors.initials: A
authors.lastname: Gugliotta
mesh_terms: D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000473:pathology; D007669:Kidney Calculi / Q000473:pathology / Q000628:therapy*; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000503:physiopathology; D008096:Lithotripsy / Q000009:adverse effects*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D016896:Treatment Outcome; D014463:Ultrasonography
chemical_list: D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid