title: Synthesis and biological evaluations of novel bendazac lysine analogues as potent anticataract agents.
abstract: Novel bendazac analogues and their salts have been designed and prepared. The resulting compounds (13c-d, 15c, 17c) showed very good aqueous solubility (>100 mg/mL). An in vitro assay showed that most of the resulting compounds had potent protective activity against the oxidative damage. Particularly, compound 13d was also able to enhance the WSP and T-AOC level in the H(2)O(2)/FeCl(3)-induced oxidative damage model, indicating the resulting compound may protect the lens through an antioxidant pathway.
authors.affiliation: School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, PR China.
authors.forename: Hong
authors.initials: H
authors.lastname: Shen
authors.forename: Shaohua
authors.initials: S
authors.lastname: Gou
authors.forename: Jianping
authors.initials: J
authors.lastname: Shen
authors.forename: Yanqin
authors.initials: Y
authors.lastname: Zhu
authors.forename: Yindi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xuetai
authors.initials: X
authors.lastname: Chen
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002386:Cataract / Q000188:drug therapy / Q000517:prevention & control*; D007191:Indazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007908:Lens, Crystalline / Q000187:drug effects / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D012995:Solubility
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D007191:Indazoles; C036067:bendazac lysine