title: Role of the neurotrophin network in eating disorders' subphenotypes: body mass index and age at onset of the disease.
abstract: Eating disorders (ED) are severe psychiatric diseases that most likely result from, and are sustained by socio-cultural, psychological and biological factors. We explored whether members of the neurotrophin family are disease-modifying factors of quantitative traits, potentially contributing to the outcome or prognosis of the disease. We studied lifetime minimum and maximum body mass index (minBMI and maxBMI) and age at onset of the disease in a sample of 991 ED patients from France, Germany, Italy and Spain and analysed 183 genetic variants located in 10 candidate genes encoding different neurotrophins and their receptors. We used a hierarchical model approach to include prior genetic knowledge of the specific and found that variants in CNTF, in its receptor CNTFR, and in NTRK2 were significantly associated with a lower age at onset of the ED. In addition, one variant in NTRK1 was associated with a higher minBMI. The results suggest that for these two subphenotypes, CNTF, CNTFR, NTRK1 and NTRK2 might act as disease-modifying factors and add preliminary evidence to the global hypothesis that EDs are the result of complex interactions and reciprocal controls between the immune, endocrine and central nervous systems.
authors.affiliation: CIBER en Epidemiología y Salud Pública (CIBERESP), Genes and Disease Program, Center for Genomic Regulation (CRG-UPF), Barcelona, Catalonia, Spain.
authors.forename: Mònica
authors.initials: M
authors.lastname: Gratacòs
authors.forename: Geòrgia
authors.initials: G
authors.lastname: Escaramís
authors.forename: Mariona
authors.initials: M
authors.lastname: Bustamante
authors.forename: Ester
authors.initials: E
authors.lastname: Saus
authors.forename: Zaida
authors.initials: Z
authors.lastname: Agüera
authors.forename: Mònica
authors.initials: M
authors.lastname: Bayés
authors.forename: Elena
authors.initials: E
authors.lastname: Cellini
authors.forename: Rafael
authors.initials: R
authors.lastname: de Cid
authors.forename: Fernando
authors.initials: F
authors.lastname: Fernández-Aranda
authors.forename: Laura
authors.initials: L
authors.lastname: Forcano
authors.forename: Juan R
authors.initials: JR
authors.lastname: González
authors.forename: Philip
authors.initials: P
authors.lastname: Gorwood
authors.forename: Johannes
authors.initials: J
authors.lastname: Hebebrand
authors.forename: Anke
authors.initials: A
authors.lastname: Hinney
authors.forename: Josep M
authors.initials: JM
authors.lastname: Mercader
authors.forename: Benedetta
authors.initials: B
authors.lastname: Nacmias
authors.forename: Nicolas
authors.initials: N
authors.lastname: Ramoz
authors.forename: Marta
authors.initials: M
authors.lastname: Ribasés
authors.forename: Valdo
authors.initials: V
authors.lastname: Ricca
authors.forename: Lucia
authors.initials: L
authors.lastname: Romo
authors.forename: Sandro
authors.initials: S
authors.lastname: Sorbi
authors.forename: Audrey
authors.initials: A
authors.lastname: Versini
authors.forename: Xavier
authors.initials: X
authors.lastname: Estivill
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D015992:Body Mass Index; D001835:Body Weight; D020934:Ciliary Neurotrophic Factor / Q000235:genetics*; D001068:Feeding and Eating Disorders / Q000453:epidemiology* / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D005602:France / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D015233:Models, Statistical; D009414:Nerve Growth Factors / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D020801:Receptor, Ciliary Neurotrophic Factor / Q000235:genetics*; D020917:Receptor, trkA / Q000235:genetics*; D020813:Receptor, trkB / Q000235:genetics*; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D055815:Young Adult
chemical_list: D020934:Ciliary Neurotrophic Factor; D009414:Nerve Growth Factors; D020801:Receptor, Ciliary Neurotrophic Factor; D020917:Receptor, trkA; D020813:Receptor, trkB