The first complete papillomavirus genome characterized from a marsupial host: a novel isolate from Bettongia penicillata.
The first fully sequenced papillomavirus (PV) of marsupials, tentatively named Bettongia penicillata papillomavirus type 1 (BpPV1), was detected in papillomas from a woylie (Bettongia penicillata ogilbyi). The circular, double-stranded DNA genome contains 7,737 bp and encodes 7 open reading frames (ORFs), E6, E7, E1, E2, E4, L2, and L1, in typical PV conformation. BpPV1 is a close-to-root PV with L1 and L2 ORFs most similar to European hedgehog PV and bandicoot papillomatosis carcinomatosis virus types 1 and 2 (BPCV1 and -2). It appears that the BPCVs arose by recombination between an ancient PV and an ancient polyomavirus more than 10 million years ago.
Bennett
Mark D
MD
School of Veterinary and Biomedical Sciences, Murdoch University, South Street, Murdoch, Western Australia 6150, Australia. m.bennett@murdoch.edu.au
Reiss
Andrea
A
Stevens
Hans
H
Heylen
Elisabeth
E
Van Ranst
Marc
M
Wayne
Adrian
A
Slaven
Michael
M
Mills
Jennifer N
JN
Warren
Kristin S
KS
O'Hara
Amanda J
AJ
Nicholls
Philip K
PK
D000818:Animals; D001483:Base Sequence; D016000:Cluster Analysis; D004247:DNA / Q000235:genetics; D004270:DNA, Circular / Q000235:genetics; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics*; D016679:Genome, Viral; D008297:Male; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010212:Papilloma / Q000662:veterinary* / Q000821:virology; D010802:Phylogeny; D011120:Polyomavirus / Q000235:genetics* / Q000302:isolation & purification; D027601:Polyomavirus Infections / Q000662:veterinary* / Q000821:virology; D048328:Potoroidae / Q000821:virology*; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014412:Tumor Virus Infections / Q000662:veterinary* / Q000821:virology; D014764:Viral Proteins / Q000235:genetics
D004270:DNA, Circular; D004279:DNA, Viral; D014764:Viral Proteins; D004247:DNA