A new protocol in photodynamic therapy: enhanced tumour cell death by combining two different photosensitizers.
The combined application of two photosensitisers (PSs), zinc(II) phthalocyanine (ZnPc) and the cationic porphyrin meso-tetrakis(4-N-methylpyridyl)porphine (T4MPyP), on HeLa cells produced an enhanced lethal effect relative to treatments with single PSs. Thus, the proper combination of PSs may constitute a new strategy to improve the efficacy of clinical photodynamic therapy.
Villanueva
Angeles
A
Departamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, Darwin 2, Edificio de Biología. E-28049, Madrid, Spain. angeles.villanueva@uam.es
Stockert
Juan Carlos
JC
Cañete
Magdalena
M
Acedo
Pilar
P
D016923:Cell Death / Q000187:drug effects*; D005260:Female; D006367:HeLa Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000627:therapeutic use*; D054833:Isoindoles; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000737:chemistry / Q000627:therapeutic use*; D011166:Porphyrins / Q000737:chemistry / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; D011166:Porphyrins; C107018:porphine; C013647:phthalocyanine