title: Heterologous expression of the oxytetracycline biosynthetic pathway in Myxococcus xanthus.
abstract: New natural products for drug discovery may be accessed by heterologous expression of bacterial biosynthetic pathways in metagenomic DNA libraries. However, a "universal" host is needed for this experiment. Herein, we show that Myxococcus xanthus is a potential "universal" host for heterologous expression of polyketide biosynthetic gene clusters.
authors.affiliation: Department of Chemistry, Syracuse University, Syracuse, New York 132441, USA.
authors.forename: D Cole
authors.initials: DC
authors.lastname: Stevens
authors.forename: Michael R
authors.initials: MR
authors.lastname: Henry
authors.forename: Kimberly A
authors.initials: KA
authors.lastname: Murphy
authors.forename: Christopher N
authors.initials: CN
authors.lastname: Boddy
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics*; D053898:Biosynthetic Pathways / Q000235:genetics*; D023061:Gene Order; D005810:Multigene Family; D016941:Myxococcus xanthus / Q000235:genetics*; D010118:Oxytetracycline / Q000096:biosynthesis*; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D011994:Recombinant Proteins; D010118:Oxytetracycline