[Effect of topiramate and carbamazepine on bone metabolism in children with epilepsy].
OBJECTIVE
To assess bone health in epileptic children who have been treated with topiramate (TPM) or carbamazepine (CBZ).


METHODS
Sixty-three epileptic children who received TPM or CBZ treatment and 36 eileptic children who did not receive any drug treatment (control group) were enrolled. Bone mineral density (BMD) at lumbar vertebrae (L1-L4) and radius-ulna was evaluated by the dual-energy X-ray absorptiometry method. Biochemical indices of bone metabolism, including serum calcium, phosphorus and alkaline phosphatase contents were measured.


RESULTS
The serum calcium content was higher in the TPM group (2.41+/-0.17 mmol/L), but it was lower in the CBZ group (2.15+/-0.26 mmol/L) than that (2.26+/-0.11 mmol/L) in the control group (p<0.05). The serum phosphorus content in both the TPM (1.55+/-0.17 mmol/L) and the CBZ groups (1.52+/-0.26 mmol/L) was significantly lower than that in the control group (1.70+/-0.30 mmol/L) (p<0.05). There were no significant differences in the serum content of alkaline phosphatase between three groups. BMD was significantly reduced in both the TPM and the CBZ groups when compared to the control group (p<0.05).


CONCLUSIONS
TPM and CBZ may result in alterations in serum contents of calcium, phosphorus and alkaline phosphatase as well as BMD reduction.
Zhang
Jing
J
Department of Pediatrics, Jinghua Central Hospital, Jinghua, Zhejiang 321000, China.
Wang
Kai-Xuan
KX
Wei
Yi
Y
Xu
Min-Hui
MH
Su
Jin-Mei
JM
Bao
Yun-Guang
YG
Zhao
Shi-Yong
SY
D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood; D000927:Anticonvulsants / Q000009:adverse effects*; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000097:blood; D002220:Carbamazepine / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D010758:Phosphorus / Q000097:blood; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D010758:Phosphorus; D005632:Fructose; D002220:Carbamazepine; D000469:Alkaline Phosphatase; D002118:Calcium