Bioactive metabolites from the sponge-derived fungus Aspergillus versicolor.
As part of an ongoing search for bioactive metabolites from the fungus Aspergillus versicolor derived from a marine sponge Petrosia sp., an aromatic polyketide derivative (1), two xanthones (2 and 3), and five anthraquinones (4-8) were isolated by bioactivity-guided fractionation. The gross structures were determined based on the NMR and MS spectroscopic data, and the absolute configurations were defined by comparison of optical rotation data with those of reported. Compounds 2, 4, 5, and 7 exhibited significant cytotoxicity against five human solid tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498, and HCT-15) with IC50 values in the range of 0.41-4.61 microg/mL. Compounds 4 and 7 exhibited antibacterial activity against several clinically isolated Gram-positive strains with MIC values of 0.78-6.25 microg/mL.
Lee
Yoon Mi
YM
College of Pharmacy, Pusan National University, Busan 609-735, Korea.
Li
Huayue
H
Hong
Jongki
J
Cho
Hee Young
HY
Bae
Kyung Sook
KS
Kim
Mi Ae
MA
Kim
Dong-Kyoo
DK
Jung
Jee H
JH
D000818:Animals; D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001230:Aspergillus / Q000378:metabolism*; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D047130:Petrosia; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D018942:Macrolides; D044004:Xanthones