Simultaneous determination of estradiol valerate and medroxyprogesterone acetate in a tablet formulation by gas chromatography-mass spectrometry.
A new and simple gas chromatography-mass spectrometry (GC-MS) method has been developed for simultaneous determination of estradiol valerate (EV) and medroxyprogesterone acetate (MPA) in a tablet formulation. The validation of the proposed method was carried out for selectivity, linearity, accuracy, precision, recovery, limits of detection and quantification. The developed method can be used for routine quality control (QC) analysis of titled drugs in combination in tablet formulation.
Yilmaz
Bilal
B
Department of Analytical Chemistry, Faculty of Pharmacy, Ataturk University, 25240 Erzurum, Turkey. bilalylmaz@yahoo.com
D004958:Estradiol / Q000031:analogs & derivatives* / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D017258:Medroxyprogesterone Acetate / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011786:Quality Control; D013607:Tablets
D004364:Pharmaceutical Preparations; D013607:Tablets; D004958:Estradiol; D017258:Medroxyprogesterone Acetate