The molecular pathogenesis of Ewing's sarcoma.
Ewing sarcoma family tumors (ESFT) are a group of aggressive solid bone and soft tissue malignancies of children and young adults characterized by specific chromosomal translocations that give rise to EWS-ETS aberrant transcription factors. Identification of EWS-ETS target genes and their role in tumor signaling networks together with the unravelling of the cell of origin will facilitate the translation into new treatment modalities for these neoplasms.
Mackintosh
Carlos
C
Laboratory of Molecular Pathology of Sarcomas, Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer, Universidad de Salamanca-CSIC, Salamanca, Spain.
Madoz-Gúrpide
Juan
J
Ordóñez
Jose Luis
JL
Osuna
Daniel
D
Herrero-Martín
David
D
D006801:Humans; D012512:Sarcoma, Ewing / Q000209:etiology* / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology