title: Gray matter correlations of cognition in incident Parkinson's disease.
abstract: We aimed to investigate whether mild cognitive impairment (MCI) in Parkinson's disease (PD) is characterized by region-specific gray matter (GM) atrophy and to explore correlations between GM and cognition in PD. Magnetic resonance images of 42 newly diagnosed PD patients (of which 11 had MCI) and 37 normal controls were analyzed using voxel-based morphometry. Analyses comparing groups showed no regional atrophy, and in patients there were no significant correlations between cognitive domain test performance and GM loss. In conclusion, GM atrophy does not seem to be a major feature of cognitive dysfunction in incident PD.
authors.affiliation: Department of Neurology, Buffalo Neuroimaging Analysis Center, State University of New York at Buffalo, Buffalo, New York, USA. datu@sus.no
authors.forename: Turi O
authors.initials: TO
authors.lastname: Dalaker
authors.forename: Robert
authors.initials: R
authors.lastname: Zivadinov
authors.forename: Jan P
authors.initials: JP
authors.lastname: Larsen
authors.forename: Mona K
authors.initials: MK
authors.lastname: Beyer
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Cox
authors.forename: Guido
authors.initials: G
authors.lastname: Alves
authors.forename: Kolbjorn
authors.initials: K
authors.lastname: Bronnick
authors.forename: Ole-Bjorn
authors.initials: OB
authors.lastname: Tysnes
authors.forename: Ronald
authors.initials: R
authors.lastname: Antulov
authors.forename: Michael G
authors.initials: MG
authors.lastname: Dwyer
authors.forename: Dag
authors.initials: D
authors.lastname: Aarsland
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D003072:Cognition Disorders / Q000209:etiology* / Q000473:pathology*; D018672:Community Health Planning; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications*; D011446:Prospective Studies