title: Doppler optical coherence tomography for interventional cardiovascular guidance: in vivo feasibility and forward-viewing probe flow phantom demonstration.
abstract: We demonstrate the potential of a forward-looking Doppler optical coherence tomography (OCT) probe for color flow imaging in several commonly seen narrowed artery morphologies. As a proof of concept, we present imaging results of a surgically exposed thrombotic occlusion model that was imaged superficially to demonstrate that Doppler OCT can identify flow within the recanalization channels of a blocked artery. We present Doppler OCT images in which the flow is nearly antiparallel to the imaging direction. These images are acquired using a flexible 2.2-mm-diam catheter that used electrostatic actuation to scan up to 30 deg ahead of the distal end. Doppler OCT images of physiologically relevant flow phantoms consisting of small channels and tapered entrance geometries are demonstrated.
authors.affiliation: University of Toronto, Department of Medical Biophysics, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Ontario, Canada.
authors.forename: Nigel R
authors.initials: NR
authors.lastname: Munce
authors.forename: Graham A
authors.initials: GA
authors.lastname: Wright
authors.forename: Adrian
authors.initials: A
authors.lastname: Mariampillai
authors.forename: Beau A
authors.initials: BA
authors.lastname: Standish
authors.forename: Michael K K
authors.initials: MK
authors.lastname: Leung
authors.forename: Louis
authors.initials: L
authors.lastname: Tan
authors.forename: Kenneth
authors.initials: K
authors.lastname: Lee
authors.forename: Brian K
authors.initials: BK
authors.lastname: Courtney
authors.forename: Aaron A
authors.initials: AA
authors.lastname: Teitelbaum
authors.forename: Bradley H
authors.initials: BH
authors.lastname: Strauss
authors.forename: I Alex
authors.initials: IA
authors.lastname: Vitkin
authors.forename: Victor X D
authors.initials: VX
authors.lastname: Yang
mesh_terms: D000818:Animals; D001157:Arterial Occlusive Diseases / Q000503:physiopathology; D004867:Equipment Design; D005263:Femoral Artery / Q000503:physiopathology; D005583:Fourier Analysis; D008955:Models, Cardiovascular; D019047:Phantoms, Imaging; D011817:Rabbits; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods; D018608:Ultrasonography, Doppler / Q000295:instrumentation* / Q000379:methods