Correlation between insulin resistance and white matter lesions among non-diabetic patients with ischemic stroke.
OBJECTIVE
We investigated whether a correlation exists between insulin resistance and the severity of cerebral white matter lesions among non-diabetic patients with ischemic stroke.


METHODS
The subjects were 105 consecutive patients without diabetes who were hospitalized due to non-cardioembolic stroke. The insulin resistance was evaluated by a homeostasis model assessment of insulin resistance (HOMA-IR). The degrees of periventricular hyperintensity (PVH) and deep and subcortical white matter hyperintensity (DSWMH) were evaluated by the brain MRI. The HOMA-IR values >or=2.5 were indicative of the insulin resistance.


RESULTS
The presence of PVH and DSWMH were 86.7 and 83.8%, respectively. The ratio of insulin resistance increased with higher grades of PVH and DSWMH. The HOMA-IR level in grade 3 PVH was significantly higher than those in grades 0 and 1. The HOMA-IR level in grade 3 DSWMH was significantly higher than those in grades 0-2. Multiple linear regression analysis showed that HOMA-IR was significantly associated with PVH or DSWMH.


CONCLUSIONS
It was found that insulin resistance correlated with white matter lesions among non-diabetic patients with non-cardiogenic ischemic stroke.
Katsumata
Toshiya
T
Department of Internal Medicine, Division of Neurology, Nephrology, and Rheumatology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan. katumata@js3.so-net.ne.jp
Otori
Tatsuo
T
Nishiyama
Yutaka
Y
Okubo
Seiji
S
Nishiyama
Yasuhiro
Y
Nagayama
Hiroshi
H
Ueda
Masayuki
M
Utsumi
Koichi
K
Yamazaki
Mineo
M
Komaba
Yuichi
Y
Katsura
Ken-Ichiro
K
Katayama
Yasuo
Y
D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000378:metabolism / Q000473:pathology*; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D016014:Linear Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000378:metabolism / Q000473:pathology*; D020521:Stroke / Q000378:metabolism / Q000473:pathology*