[Bone turnover markers evaluation in psoriatic arthritis].
The aim of this study was to investigate the blood level of bone turnover markers: osteoprotegerin (OPG), bone alkaline phosphatase (Bone-ALP), and receptor activator of NF-kappa B ligand (RANKL) of patients with psoriatic arthritis.


METHODS
Twenty-four patients with psoriatic arthritis (CASPAR classification criteria) and twenty healthy controls were included. The OPG, Bone-ALP and RANKL levels were quantified by using ELISA method.


RESULTS
Peripheral blood levels of bone turnover markers were higher in psoriatic arthritis than martors and there was a strong negative correlation between OPG-RANKL and Bone-ALP- RANKL.


CONCLUSIONS
The OPG and Bone-ALP serum level is strongly negative related to the increase in RANKL serum level in patients with psoriatic arthritis. The increase in OPG and Bone-ALP serum level induces the production of bone matrix parallel to the bone destruction mediated by RANKL. Follow up of patients with psoriatic arthritis, by use of early determination of RANKL, OPG and Bone-ALP serum levels, and also of bone metabolism markers (they have specific role in bone remodeling), allows a precise evaluation of disease activity and, in future, could be a criteria for the initiation of specific, targeting treatment.
Ciacli
Camelia
C
Universitatea de Vest "V. Goldiş" Arad, Facultatea de Medicină, Clinica de Medicină internă - Imunologie, Spitalul Clinic Judeţean Arad.
Puşchiţă
Maria
M
Drugărin
Doina
D
Solovan
C
C
Gurban
Camelia Vidita
CV
Cotoraci
Coralia
C
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood*; D015535:Arthritis, Psoriatic / Q000097:blood* / Q000175:diagnosis / Q000201:enzymology; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D053244:Osteoprotegerin / Q000097:blood*; D011237:Predictive Value of Tests; D053246:Receptor Activator of Nuclear Factor-kappa B / Q000097:blood*; D012720:Severity of Illness Index
D015415:Biomarkers; D053244:Osteoprotegerin; D053246:Receptor Activator of Nuclear Factor-kappa B; D000469:Alkaline Phosphatase