LHRH-targeted nanoparticles for cancer therapeutics.
Synthesis and evaluation of a novel cancer cell's receptor-targeted internally quaternized and surface neutral poly(amidoamine) (PAMAM) generation four dendrimer as well as PAMAM-paclitaxel conjugate are described. The advantages of developed nanocarriers include but are not limited to (1) internal cationic charges for the complexation with small interfering RNA or antisense oligonucleotides and their protection from the degradation in systemic circulation; (2) neutral-modified surface for low cytotoxicity of empty unloaded dendrimers; (3) efficient internalization by cancer cells; and (4) preferential accumulation in the tumor and the prevention of adverse side effects of chemotherapy.
Minko
Tamara
T
Department of Pharmaceutics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA.
Patil
Mahesh L
ML
Zhang
Min
M
Khandare
Jayant J
JJ
Saad
Maha
M
Chandna
Pooja
P
Taratula
Oleh
O
D000107:Acetylation / Q000187:drug effects; D000818:Animals; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000737:chemistry / Q000627:therapeutic use*; D051379:Mice; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry / Q000627:therapeutic use*; D009369:Neoplasms / Q000628:therapy*; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology; D013499:Surface Properties / Q000187:drug effects; D014018:Tissue Distribution / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
D050091:Dendrimers; C104700:PAMAM Starburst; D007987:Gonadotropin-Releasing Hormone; D017239:Paclitaxel