title: Impact of tadalafil once daily in men with erectile dysfunction--including a report of the partners' evaluation.
abstract: OBJECTIVE
  To evaluate the effect of tadalafil 5 mg taken once daily on efficacy (erection achievement and penetration) and overall sexual satisfaction in men with erectile dysfunction (ED) and their female partners.
  
  
  METHODS
  This retrospective analysis included data pooled from 2 multicenter, randomized, double-blind, placebo-controlled trials that included 505 couples (tadalafil, n=373; placebo, n=132) in which the men received tadalafil 5 mg once daily or placebo for 12 weeks. Individual Sexual Encounter Profile (SEP) diaries were completed independently by the male subject and his female partner after each sexual intercourse attempt. The mean per-subject/per-partner percentage of "yes" responses to SEP diary questions were assessed, as was agreement between subjects' and partners' responses.
  
  
  RESULTS
  Subjects and partners in the tadalafil-treated group reported significantly greater improvements in the man's ability to achieve some erection, vaginal penetration, and overall sexual satisfaction compared with the placebo-treated group (P<.001). For all intercourse attempts, the mean per-couple percentage of agreement for those in the tadalafil and placebo groups, respectively, was high for erection achievement (99.0% and 96.6%), vaginal penetration (98.6% and 97.4%), and overall satisfaction (84.3% and 82.8%).
  
  
  CONCLUSIONS
  Tadalafil 5 mg taken once daily as treatment for ED improved overall satisfaction for men and their female partners. This analysis demonstrates the high concordance among couples in their responses to the man's treatment for ED.
authors.affiliation: Center for Marital and Sexual Health of South Florida, West Palm Beach, Florida 33401, USA. Stanley.Althof@case.edu
authors.forename: Stanley E
authors.initials: SE
authors.lastname: Althof
authors.forename: Eusebio
authors.initials: E
authors.lastname: Rubio-Aurioles
authors.forename: Sheryl
authors.initials: S
authors.lastname: Kingsberg
authors.forename: Haoyue
authors.initials: H
authors.lastname: Zeigler
authors.forename: David G
authors.initials: DG
authors.lastname: Wong
authors.forename: Patrick
authors.initials: P
authors.lastname: Burns
mesh_terms: D000328:Adult; D002243:Carbolines / Q000008:administration & dosage*; D015331:Cohort Studies; D003075:Coitus; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D007172:Erectile Dysfunction / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017060:Patient Satisfaction / Q000706:statistics & numerical data; D010413:Penis / Q000187:drug effects; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage*; D011336:Probability; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D012747:Sexual Partners; D000068581:Tadalafil; D016896:Treatment Outcome
chemical_list: D002243:Carbolines; D010726:Phosphodiesterase Inhibitors; D000068581:Tadalafil