[Study of genetic determination of base clinical components of metabolic syndrome].
Genetic analysis was carried out on the material including clinic and genealogical data about 510 patients with type 2 Diabetes Mellitus, 445 Essential Hypertension individuals, 239 abdominal obesity persons and their 1st degree relatives. It has been shown that the Essential Hypertension and abdominal obesity distribution in the population and families can be described by means of a variants polygene model with essential influence of the major genes. Gene complexes of predisposition to obesity, Essential Hypertension and Type 2 Diabetes Mellitus are independent, however, their liabilities are covered.
Shtandel'
S A
SA
Bariliak
I R
IR
Kravchun
N A
NA
Snegurskaia
I A
IA
Miloslavskiĭ
D K
DK
Levchenko
T P
TP
D000328:Adult; D001824:Body Constitution / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D005828:Genetics, Population; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology / Q000235:genetics*; D056128:Obesity, Abdominal / Q000453:epidemiology / Q000235:genetics; D010375:Pedigree; D019655:Quantitative Trait, Heritable