Water-tolerant and reusable Lewis acid catalyst for the one-pot synthesis of 3,4-dihydropyrimidin-2-(1H)-ones under solvent-free conditions.
3,4-Dihydropyrimidin-2-(1H)-ones were synthesized in high yields by a one-pot cyclocondensation of an aldehyde, a 1,3-dicarbonyl compound, and urea using copper methanesulfonate (2 mol%) as a recyclable catalyst under solvent-free conditions in short reaction time (1-2 h).
Wang
Min
M
College of Chemistry and Chemical Engineering, Bohai University, Jinzhou, Liaoning, P R China. minwangzg@yahoo.com.cn
Song
Zhiguo
Z
Jiang
Heng
H
Gong
Hong
H
D000143:Acids / Q000737:chemistry; D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D004339:Drug Compounding / Q000379:methods; D011744:Pyrimidinones / Q000138:chemical synthesis*; D012997:Solvents / Q000737:chemistry; D014508:Urea / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
C507290:3,4-dihydropyridopyrimidin-2(1H)-one; D000143:Acids; D000447:Aldehydes; D011744:Pyrimidinones; D012997:Solvents; D014867:Water; D014508:Urea