Does the histamine H4 receptor have a pro- or anti-inflammatory role in murine bronchial asthma?
The histamine H4 receptor is expressed preferentially on immune cells, indicating a possible role of the H4 receptor in inflammation. Studies of inflammation in several animal models point to a pro-inflammatory function of the H4 receptor. However, studies on experimental murine bronchial asthma yielded conflicting results, a fact which is neglected in most H4 receptor publications. Therefore, the present review critically analyzes available data on the role of the H4 receptor in the murine bronchial asthma model.
Neumann
Detlef
D
Institute of Pharmacology, Hannover Medical School, Hannover, Germany. neumann.detlef@mh-hannover.de
Beermann
Silke
S
Seifert
Roland
R
D000818:Animals; D001249:Asthma / Q000503:physiopathology*; D004195:Disease Models, Animal; D006632:Histamine / Q000502:physiology; D006801:Humans; D007211:Indoles / Q000494:pharmacology; D007249:Inflammation / Q000503:physiopathology; D051379:Mice; D010879:Piperazines / Q000494:pharmacology; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects / Q000502:physiology*; D011968:Receptors, Histamine / Q000187:drug effects / Q000502:physiology*; D018100:Receptors, Histamine H3 / Q000502:physiology; D000074040:Receptors, Histamine H4
C498829:Hrh4 protein, mouse; D007211:Indoles; D010879:Piperazines; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D018100:Receptors, Histamine H3; D000074040:Receptors, Histamine H4; C484309:1-((5-chloro-1H-indol-2-yl)carbonyl)-4-methylpiperazine; D006632:Histamine