Gold(I)-catalyzed tandem cyclization approach to tetracyclic indolines.
Two highly stereoselective cationic gold(I)-catalyzed tandem cyclization reactions of alkynylindoles are described. These reactions demonstrated a novel and general strategy to rapidly construct highly functionalized polycyclic indolines. This approach was successfully employed for a formal synthesis of the akuammiline alkaloid minfiensine.
Liu
Yongxiang
Y
Department of Chemistry and Biochemistry, University of Colorado, Boulder, Colorado 80309, USA.
Xu
Wenqing
W
Wang
Xiang
X
D002384:Catalysis; D018360:Crystallography, X-Ray; D003500:Cyclization; D006046:Gold / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D050607:Organogold Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D007211:Indoles; D050607:Organogold Compounds; C057812:indoline; D006046:Gold