title: The effect of a structured exercise program on nutrition and fitness outcomes in human immunodeficiency virus-infected children.
abstract: The feasibility and effectiveness of a hospital-based exercise-training program followed by a home-based program for improving fitness, strength, and changes in body composition in children and adolescents with HIV were evaluated. Subjects participated in nonrandomized 24-session, hospital supervised exercise training program followed by an 314 unsupervised home-based maintenance program. Outcome measurements included muscular strength/endurance, flexibility, relative peak VO(2), body composition, and lipids. Seventeen subjects (eight females) with a median age of 15.0 years (range: 6.0-22.6) and BMI z-score of 0.61 (range: -1.70-2.57) at entry completed the intervention. After 24 training sessions, the median increases in muscular strength were between 8% and 50%, depending on muscle group. The median increases in muscle endurance, relative peak VO(2), and lean body mass were 38.7% (95% CI: 12.5-94.7; p = 0.006), 3.0 ml/kg/min (95% CI: 1.5-6.0; p < 0.001), and 4.5% (95% CI: 2.4-6.6; p < 0.001), respectively. Twelve children completed the home-based maintenance program. Median changes in these outcomes between completion of the hospital-based intervention and a follow-up after completion of the home-based program were near zero. No adverse events occurred during the intervention. A supervised hospital-based fitness program is feasible, safe, and effective for improving general fitness and strength as well as lean body mass in children with HIV.
authors.affiliation: Division of Pediatric Clinical Research, Department of Pediatrics, Miller School of Medicine, University of Miami, Batchelor Children's Research Institute, Miami, Florida 33101, USA. tracie.miller@miami.edu
authors.forename: Tracie L
authors.initials: TL
authors.lastname: Miller
authors.forename: Gabriel
authors.initials: G
authors.lastname: Somarriba
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Kinnamon
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Weinberg
authors.forename: Lawrence B
authors.initials: LB
authors.lastname: Friedman
authors.forename: Gwendolyn B
authors.initials: GB
authors.lastname: Scott
mesh_terms: D000293:Adolescent; D001823:Body Composition; D002648:Child; D005081:Exercise Therapy / Q000009:adverse effects / Q000379:methods*; D005260:Female; D006678:HIV; D015658:HIV Infections / Q000628:therapy* / Q000821:virology; D006699:Home Care Services; D006761:Hospitals; D006801:Humans; D008055:Lipids / Q000032:analysis; D008297:Male; D053580:Muscle Strength; D015596:Nutrition Assessment; D010807:Physical Endurance; D010809:Physical Fitness; D016059:Range of Motion, Articular; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D008055:Lipids