title: Lower lid entropion secondary to treatment with alpha-1a receptor antagonist: a case report.
abstract: BACKGROUND
  The use of alpha-1a receptor antagonists (tamsulosin) is widely accepted in the treatment of benign prostatic hypertrophy (BPH). It has previously been implicated as a causative agent in intra-operative floppy iris syndrome due to its effects on the smooth muscle. We report a case of lower lid entropion that may be related to a patient commencing treatment of tamsulosin.
  
  
  METHODS
  A 74-year-old Caucasian man was started on alpha 1-a receptor antagonist (Tamsulosin) treatment for benign prostatic hypertrophy. Eight days later, he presented to the ophthalmology unit with a right lower lid entropion which was successfully treated surgically with a Weiss procedure.
  
  
  CONCLUSIONS
  We report a case of lower lid entropion that may be secondary to the recent use of an alpha-1a blocker (tamsulosin). This can be explained by considering the effect of autonomic blockade on alpha-1 receptors in the Muller's muscle on a patient that may already have an anatomical predisposition to entropion formation due to a further reduction in muscle tone.
authors.affiliation: West of England Eye Unit, Royal Devon and Exeter NHS Hospital, Barrack Road, Exeter, Devon, EX2 5DS, UK. salmanwqr@gmail.com.
authors.forename: Salman
authors.initials: S
authors.lastname: Waqar
authors.forename: Peter
authors.initials: P
authors.lastname: Simcock