title: [Study on the association of cytochrome P450 polymorphisms and the risk of esophageal cancer: a meta-analysis].
abstract: OBJECTIVE
  To examine the association between CYP1A1 polymorphisms (MspI and Ile/Val) and esophageal cancer (EC) by systematically reviewing the risk of the original studies.
  
  
  METHODS
  Data from 16 papers (8 for MspI, 14 for Ile/Val) regarding case-control studies on the association of cytochrome P450 polymorphisms and risk of esophageal cancer was analyzed by dominant model (variant genotype vs. wild-type genotype) through meta-analysis. Stratified analysis was carried out according to the pathological types.
  
  
  RESULTS
  In systematical analysis, CYP1A1 MspI variant genotype (TC + CC) had no association with EC risk (OR = 1.17, 95%CI: 0.82 - 1.66). Similar results were observed in esophageal squamous-cell carcinoma (ESCC) (OR = 1.17, 95%CI: 0.82 - 1.69) and esophageal adenocarcinoma (EAC) (OR = 1.39, 95%CI: 0.67 - 2.09). Individuals with the CYP1A1 Ile/Val variant genotype (Ile/Val + Val/Val) had an increased risk for EC, when comparing with wild type (Ile/Ile), with an OR of 1.39 (95%CI: 1.07 - 1.80). CYP1A1 Ile/Val variant genotype could increase the risk of ESCC (OR = 1.43, 95%CI: 1.07 - 1.91) but no significant association was found with EAC (OR = 1.20, 95%CI: 0.62 - 2.30).
  
  
  CONCLUSIONS
  CYP1A1 gene polymorphism Ile/Val might have played a role in the development of ESCC but CYP1A1 MspI polymorphism might not be associated with the susceptibility of EC.
authors.affiliation: College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Dai
authors.forename: Yan-ping
authors.initials: YP
authors.lastname: Wang
authors.forename: Xiao-bing
authors.initials: XB
authors.lastname: Wu
authors.forename: Kai-juan
authors.initials: KJ
authors.lastname: Wang
authors.forename: Quan-jun
authors.initials: QJ
authors.lastname: Lv
mesh_terms: D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D004938:Esophageal Neoplasms / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic
chemical_list: D019363:Cytochrome P-450 CYP1A1