title: Nanonization strategies for poorly water-soluble drugs.
abstract: Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL). In this review, several major nanonization techniques that seek to overcome these limitations for drug solubilization are presented. Strategies including drug nanocrystals, nanoemulsions and polymeric micelles are reviewed. Finally, perspectives on existing challenges and future opportunities are highlighted.
authors.affiliation: Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
authors.forename: Huabing
authors.initials: H
authors.lastname: Chen
authors.forename: Chalermchai
authors.initials: C
authors.lastname: Khemtong
authors.forename: Xiangliang
authors.initials: X
authors.lastname: Yang
authors.forename: Xueling
authors.initials: X
authors.lastname: Chang
authors.forename: Jinming
authors.initials: J
authors.lastname: Gao
mesh_terms: D001682:Biological Availability; D004337:Drug Carriers; D006801:Humans; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000378:metabolism; D012995:Solubility; D014867:Water
chemical_list: D004337:Drug Carriers; D008823:Micelles; D004364:Pharmaceutical Preparations; D014867:Water