[Neuronal plasticity and gene expression].
Neuronal plasticity--a fundamental feature of brain--provides adequate interactions with dynamic environment. One of the most deeply investigated forms of the neuronal plasticity is a long-term potentiation (LTP)--a phenomenon underlying learning and memory. Signal paths activated during LTP converge into the nuclear of the neuron, giving rise to launch of the molecular-genetic programs, which mediate structural and functional remodeling of synapses. In the review data concerning involvement of multilevel gene expression into plastic change under neuronal activation are summarized.
Sokolova
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Shtark
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Lisachev
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D000818:Animals; D001921:Brain / Q000502:physiology*; D002493:Central Nervous System Diseases / Q000235:genetics / Q000503:physiopathology; D015870:Gene Expression; D005786:Gene Expression Regulation; D006801:Humans; D007858:Learning / Q000502:physiology; D017774:Long-Term Potentiation; D008568:Memory / Q000502:physiology; D009473:Neuronal Plasticity / Q000235:genetics / Q000502:physiology*