title: Highly acylated diterpenoids with a new 3,4-secograyanane skeleton from the flower buds of Rhododendron molle.
abstract: Four highly acylated diterpenoids with a new 3,4-secograyanane skeleton, secorhodomollolides A-D (1-4), have been isolated from the flower buds of Rhododendron molle. Their structures including absolute configurations were determined on the basis of spectroscopic data interpretation and single-crystal X-ray crystallography. Compound 4 exhibited significant analgesic and sedative effects at a dose of 5 mg/kg, and compound 2 showed selective cytotoxic activity against human hepatoma carcinoma cell line (Bel-7402) with IC(50) 0.97 microM.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing 100050, People's Republic of China.
authors.forename: Sujuan
authors.initials: S
authors.lastname: Wang
authors.forename: Sheng
authors.initials: S
authors.lastname: Lin
authors.forename: Chenggen
authors.initials: C
authors.lastname: Zhu
authors.forename: Yongchun
authors.initials: Y
authors.lastname: Yang
authors.forename: Shuai
authors.initials: S
authors.lastname: Li
authors.forename: Jianjun
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaoguang
authors.initials: X
authors.lastname: Chen
authors.forename: Jiangong
authors.initials: J
authors.lastname: Shi
mesh_terms: D000215:Acylation; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D035264:Flowers / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D029793:Rhododendron / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C550224:3,4-secograyanane; D004224:Diterpenes; C550225:secorhodomollolide A