Protein acetylation in synaptic plasticity and memory.
Posttranslational modifications of proteins regulate various processes in the cells. The seminal role of phosphorylation in synaptic plasticity and memory has been established using several different model systems. Recently, an important role for another posttranslational modification, acetylation, particularly of histones, has emerged in these processes. This review focuses on the role of activity-dependent protein acetylation in synaptic plasticity and memory.
Sharma
Shiv K
SK
National Brain Research Centre, Cellular and Molecular Neuroscience, Manesar, Haryana, India. sharmas@nbrc.ac.in
D000107:Acetylation; D000818:Animals; D006801:Humans; D008568:Memory / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D013569:Synapses / Q000378:metabolism*