title: Effects of chronic ethanol consumption on levels of adipokines in visceral adipose tissues and sera of rats.
abstract: OBJECTIVE
  To investigate the effects of ethanol on adipokines (leptin, adiponectin, resistin, visfatin and cartonectin) levels in visceral adipose tissue (VAT) and sera, and explore the correlation between VAT and serum adipokine levels.
  
  
  METHODS
  Forty-eight Wistar rats were randomly divided into control, low, middle and high ethanol treatment groups that received 0, 0.5, 2.5, or 5.0 g of ethanol x kg(-1) x d(-1), respectively, via gastric tubes for 22 weeks. The levels of fasting blood glucose (FBG) and fasting serum insulin (FINS) were measured and homeostasis model assessment of insulin resistance (HOMA-IR) values were calculated. Adipokines in perirenal and epididymal VAT and sera were measured by enzyme-linked immunosorbent assays (ELISAs).
  
  
  RESULTS
  High-dose treatments of ethanol (vs control group) significantly increased FINS (eg 37.86%) and HOMA-IR values (eg 40.63%). In VAT, levels of leptin, resistin and visfatin in the middle- and high-dose groups were significantly elevated, whereas adiponectin and cartonectin levels decreased. In sera, changes in adipokine levels were similar to that observed in VAT, with the exception of cartonectin. These ethanol-induced effects were dose-dependent. A positive correlation existed between VAT and serum adipokine levels, except for cartonectin.
  
  
  CONCLUSIONS
  Chronic ethanol consumption affects adipokine levels in VAT and sera in a dose-dependent manner, with the exception of serum cartonectin. The altered levels of adipokines in VAT and sera are positively correlated.
authors.affiliation: Provincial Hospital Affiliated to Shandong University, Ji-nan 250021, China.
authors.forename: Heng-cai
authors.initials: HC
authors.lastname: Yu
authors.forename: Si-ying
authors.initials: SY
authors.lastname: Li
authors.forename: Ming-feng
authors.initials: MF
authors.lastname: Cao
authors.forename: Xiu-yun
authors.initials: XY
authors.lastname: Jiang
authors.forename: Li
authors.initials: L
authors.lastname: Feng
authors.forename: Jia-jun
authors.initials: JJ
authors.lastname: Zhao
authors.forename: Ling
authors.initials: L
authors.lastname: Gao
mesh_terms: D054392:Adipokines / Q000097:blood* / Q000378:metabolism*; D052242:Adiponectin / Q000097:blood / Q000378:metabolism; D000818:Animals; D000431:Ethanol / Q000378:metabolism*; D007333:Insulin Resistance; D050152:Intra-Abdominal Fat / Q000378:metabolism*; D020738:Leptin / Q000097:blood / Q000378:metabolism; D008297:Male; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D052243:Resistin / Q000097:blood / Q000378:metabolism
chemical_list: D054392:Adipokines; D052242:Adiponectin; D020738:Leptin; D052243:Resistin; D000431:Ethanol; D054409:Nicotinamide Phosphoribosyltransferase