Protective value of a folkloric medicinal plant extract against mortality and hemorrhage in a life-threatening renal trauma model.
OBJECTIVE
To compare the efficacy of a folkloric medicinal plant extract (Ankaferd Blood Stopper [ABS]) with that of oxidized cellulose (Surgicel) in a life-threatening renal injury model. ABS is a mixture of 5 plants that has historically been used in Turkish traditional medicine. It has been approved by the Ministry of Health to manage external hemorrhage and dental surgery bleeding in Turkey.


METHODS
Twenty-two Wistar albino rats underwent partial nephrectomy after intravenous heparin anticoagulation (2000 U/kg). The cut surface received 1 of 3 therapies, namely no treatment, Surgicel (Johnson & Johnson, New Brunswick, NJ) or ABS (Trend Teknoloji Iaç AS, Istanbul, Turkey). Blood pressure was continually monitored. Survival time, total blood loss, and mean arterial pressure were recorded for 60 minute or until death. Rats that were alive (mean arterial pressure>or=20 mm Hg) at the end of 60 minutes were sacrificed with blood withdrawal with the help of catheters.


RESULTS
All animals that received no treatment died within 60 minutes of follow-up. One of 7 in the Surgicel group, and 5 of 7 animals in the ABS group, survived. Mean survival times for the Surgicel and ABS groups were 42.7 and 53.4 minutes, respectively. Rats in the ABS and Surgicel groups survived significantly longer than rats in the control group (P<.05). There were no significant differences between the ABS and the Surgicel groups in survival (P=.128).


CONCLUSIONS
ABS is as effective as Surgicel in achieving hemostasis and lengthening survival time following partial nephrectomy in an experimental rat model.
Tokgöz
Hüsnü
H
Department of Urology, Karaelmas University School of Medicine, Zonguldak, Turkey. h_tokgoz@hotmail.com
Karakaya
Kemal
K
Hanci
Volkan
V
Abduşoğlu
Mustafa
M
Erol
Bülent
B
Türksoy
Ozlem
O
Akduman
Bülent
B
Mungan
Necmettin Aydin
NA
D000818:Animals; D002483:Cellulose, Oxidized / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D006470:Hemorrhage / Q000188:drug therapy / Q000517:prevention & control*; D006490:Hemostatics / Q000627:therapeutic use; D015601:Injury Severity Score; D007668:Kidney / Q000187:drug effects / Q000293:injuries*; D008297:Male; D009392:Nephrectomy / Q000379:methods; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000627:therapeutic use*; D011336:Probability; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D015996:Survival Rate; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000401:mortality*
D002483:Cellulose, Oxidized; D006490:Hemostatics; D010936:Plant Extracts; C539751:ankaferd blood stopper