title: In situ synthesis of calcium phosphate-polycaprolactone nanocomposites with high ceramic volume fractions.
abstract: Biodegradable calcium phosphate-PCL nanocomposite powders with unusually high ceramic volume fractions (80-95%) and uniform PCL distribution were synthesized by a non-aqueous chemical reaction in the presence of the dissolved polymer. No visible polymer separation occurred during processing. Depending on the reagents combination, either dicalcium phosphate (DCP) or Ca-deficient HA (CDHA) was obtained. CDHA-PCL composite powders were high pressure consolidated at room temperature yielding dense materials with high compressive strengths. Such densification route provides the possibility of incorporating drug and proteins without damaging their biological activity. The CDHA-PCL composites were tested in osteoblastic and endothelial cell line cultures and were found to support the attachment and proliferation of both cell types.
authors.affiliation: Faculty of Materials Engineering, Technion-IIT, Haifa, Israel.
authors.forename: C
authors.initials: C
authors.lastname: Makarov
authors.forename: I
authors.initials: I
authors.lastname: Gotman
authors.forename: X
authors.initials: X
authors.lastname: Jiang
authors.forename: S
authors.initials: S
authors.lastname: Fuchs
authors.forename: C J
authors.initials: CJ
authors.lastname: Kirkpatrick
authors.forename: E Y
authors.initials: EY
authors.lastname: Gutmanas
mesh_terms: D002130:Calcium Phosphates / Q000737:chemistry*; D002460:Cell Line; D045744:Cell Line, Tumor; D002516:Ceramics / Q000138:chemical synthesis*; D042783:Endothelial Cells; D006801:Humans; D008420:Manufactured Materials; D053761:Nanocomposites / Q000737:chemistry*; D010006:Osteoblasts / Q000166:cytology; D011091:Polyesters; D011108:Polymers
chemical_list: D002130:Calcium Phosphates; D011091:Polyesters; D011108:Polymers; C016240:polycaprolactone; C020243:calcium phosphate