Temporal and spatial dynamics of rabies viruses in China and Southeast Asia.
Phylogenetic studies have revealed a profound understanding about the biodiversity of rabies viruses in China, but little is known about their evolutionary dynamics in the country. In the present study, the complete G gene sequences of 33 rabies virus isolates (RABVs) isolated from distinct Chinese provinces were determined and phylogenetic analysis was conducted using these G sequences and 93 others retrieved from GenBank representing China and Southeast Asia. Further evolutionary history of RABV was estimated using a Bayesian Markov chain Monte Carlo method to understand the temporal and spatial dynamics of this virus. Results showed that rabies viruses in China and Southeast Asia share a common ancestor and form 2 clades with each being further divided into 3 lineages. The time of the most recent common ancestor of current RABV strains was estimated to be year 1654 (1514-1812) and the viruses circulating in Southeast Asia likely derived from China.
Gong
Wenjie
W
Institute of Zoonoses, Jilin University, Changchun 130062, China.
Jiang
Yu
Y
Za
Yunfeng
Y
Zeng
Zheng
Z
Shao
Mingfu
M
Fan
Jinhong
J
Sun
Yanwei
Y
Xiong
Zhonglian
Z
Yu
Xinglong
X
Tu
Changchun
C
D000818:Animals; D000956:Antigens, Viral / Q000235:genetics*; D001210:Asia, Southeastern / Q000453:epidemiology; D002417:Cattle; D002681:China / Q000453:epidemiology; D016000:Cluster Analysis; D004285:Dogs; D019143:Evolution, Molecular; D005843:Geography; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D011818:Rabies / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D011820:Rabies virus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013552:Swine; D013997:Time Factors; D014759:Viral Envelope Proteins / Q000235:genetics*
D000956:Antigens, Viral; D006023:Glycoproteins; D012367:RNA, Viral; D014759:Viral Envelope Proteins; C064951:glycoprotein G, Rabies virus