title: Synthesis, anticonvulsant and toxicity screening of newer pyrimidine semicarbazone derivatives.
abstract: A number of N-(4,6-substituted diphenylpyrimidin-2-yl) semicarbazones (4a-t) were synthesized and tested for their anticonvulsant activity against the two seizure models, maximal electroshock seizure (MES) and subcutaneous pentylenetetrazole (scPTZ). All the synthesized compounds possessed the four essential pharmacophoric elements for good anticonvulsant activity. Most of the compounds displayed good anticonvulsant activity with lesser neurotoxicity. To assess the unwanted effects of the compounds on liver, estimation of enzymes and proteins was carried out.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India. dr.ozairalam@gmail.com
authors.forename: Ozair
authors.initials: O
authors.lastname: Alam
authors.forename: Pooja
authors.initials: P
authors.lastname: Mullick
authors.forename: S P
authors.initials: SP
authors.lastname: Verma
authors.forename: Sadaf J
authors.initials: SJ
authors.lastname: Gilani
authors.forename: Suroor A
authors.initials: SA
authors.lastname: Khan
authors.forename: Nadeem
authors.initials: N
authors.lastname: Siddiqui
authors.forename: Waquar
authors.initials: W
authors.lastname: Ahsan
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D004357:Drug Synergism; D004827:Epilepsy / Q000188:drug therapy; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D009420:Nervous System / Q000187:drug effects; D011743:Pyrimidines / Q000737:chemistry*; D012664:Semicarbazones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity*
chemical_list: D000927:Anticonvulsants; D011743:Pyrimidines; D012664:Semicarbazones; C030986:pyrimidine