Energy crosstalk between DNA lesions: implications for allosteric coupling of DNA repair and triplet repeat expansion pathways.
Energy coupling between distal DNA domains may have profound regulatory consequences for biological processes, allowing for allosteric control of nucleic acid function. Repair of oxidative lesions at or near triplet repeat domains can enhance DNA expansion events that result in debilitating disease states. We report here position, distance, and lesion-dependent energy crosstalk between pairs of lesions in a triplet repeat bulge loop and an adjacent duplex domain. We discuss the implications of such coupled communication between lesions in distal loop and duplex domains for lesion repair and DNA expansion associated with diseases.
Völker
Jens
J
Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, 610 Taylor Road, Piscataway, New Jersey 08854, USA.
Plum
G Eric
GE
Klump
Horst H
HH
Breslauer
Kenneth J
KJ
D001483:Base Sequence; D003080:Cold Temperature; D004247:DNA; D004249:DNA Damage; D004260:DNA Repair; D006358:Hot Temperature; D008969:Molecular Sequence Data; D010084:Oxidation-Reduction; D015398:Signal Transduction; D013696:Temperature; D013816:Thermodynamics; D019680:Trinucleotide Repeat Expansion
D004247:DNA