title: Insulin resistance, dyslipidemia, and metabolic syndrome in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To investigate the association of insulin resistance with dyslipidemia and metabolic syndrome (MBS) in women with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Fasting glucose (G), insulin (I), and lipid levels were measured in 50 infertile women with PCOS. A fasting G/I ratio of 4.5 or less (n=29) defined insulin resistance (IR).
  
  
  RESULTS
  The mean levels of total cholesterol (P<0.001), low-density lipoprotein (P=0.02), and triglycerides (P<0.001) were significantly higher and the mean levels of high-density lipoprotein were significantly lower (P<0.001) in the IR group. The prevalence of MBS (P=0.02) and obesity (P=0.04), hypertension (P=0.02), fasting hyperglycemia (P=0.03), low high-density lipoprotein levels (P=0.02), and hypertriglyceridemia (P=0.02) were also significantly higher in the IR group.
  
  
  CONCLUSIONS
  Insulin resistance is associated with dyslipidemia and MBS in women with PCOS. Lifestyle modification and insulin-sensitizing agents should be part of the management plan.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Cairo University, Egypt.
authors.forename: Akmal
authors.initials: A
authors.lastname: El-Mazny
authors.forename: Nermeen
authors.initials: N
authors.lastname: Abou-Salem
authors.forename: Walid
authors.initials: W
authors.lastname: El-Sherbiny
authors.forename: Ahmed
authors.initials: A
authors.lastname: El-Mazny
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology / Q000209:etiology; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology; D007328:Insulin / Q000378:metabolism; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000209:etiology; D009765:Obesity / Q000453:epidemiology / Q000209:etiology; D011085:Polycystic Ovary Syndrome / Q000503:physiopathology*; D015995:Prevalence; D012307:Risk Factors; D055815:Young Adult
chemical_list: D007328:Insulin; D008055:Lipids; D005947:Glucose