title: NMR structure/function relationships of peptides corresponding to the C1B1 Region of PKC gamma.
abstract: The region (101-112) of C1B domain in PKC gamma plays a crucial role in the activation of the enzyme and subsequent gap junction inhibition. Substitution studies on peptides correlating to the C1B region show that a flexible structure and ability to be phosphorylated on serine 109 are critical for this purpose.
authors.affiliation: Department of Biochemistry, Chalmers Hall, Kansas State University, Manhattan, KS 66506, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Lauer
authors.forename: Debarshi
authors.initials: D
authors.lastname: Banerjee
authors.forename: Denton
authors.initials: D
authors.lastname: Shanks
authors.forename: Huaien
authors.initials: H
authors.lastname: Dai
authors.forename: Yu-Xi
authors.initials: YX
authors.lastname: Gong
authors.forename: Om
authors.initials: O
authors.lastname: Prakash
authors.forename: Dolores
authors.initials: D
authors.lastname: Takemoto
mesh_terms: D048948:14-3-3 Proteins / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001667:Binding, Competitive; D002470:Cell Survival; D002478:Cells, Cultured; D017629:Gap Junctions; D008954:Models, Biological; D008969:Molecular Sequence Data; D009154:Mutation; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D010455:Peptides / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D011493:Protein Kinase C / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary / Q000235:genetics; D011817:Rabbits; D013329:Structure-Activity Relationship
chemical_list: D048948:14-3-3 Proteins; D010455:Peptides; C087857:protein kinase C gamma; D011493:Protein Kinase C