Development and functional specialization of CD103+ dendritic cells.
CD103 (alpha(E)) integrin expression distinguishes a population of dendritic cells (DCs) that can be found in many if not all lymphoid and non-lymphoid organs. CD103(+) DCs display distinct functional activities. Migratory CD103(+) DCs derived from skin, lung, and intestine efficiently present exogenous antigens in their corresponding draining lymph nodes to specific CD8(+) T cells through a mechanism known as cross-presentation. On the T cells they prime, intestinal CD103(+) DCs can drive the induction of the chemokine receptor CCR9 and alpha(4)beta(7) integrin, both known as gut-homing receptors. CD103(+) DCs also contribute to control inflammatory responses and intestinal homeostasis by fostering the conversion of naive T cells into induced Foxp3(+) regulatory T cells, a mechanism that relies on transforming growth factor-beta and retinoic acid signaling. This review discusses recent findings that identify murine CD103(+) DCs as important regulators of the immune response.
del Rio
Maria-Luisa
ML
Institute of Immunology, Hannover Medical School, Hannover, Germany.
Bernhardt
Günter
G
Rodriguez-Barbosa
Jose-Ignacio
JI
Förster
Reinhold
R
D000818:Animals; D017951:Antigen Presentation; D015703:Antigens, CD / Q000276:immunology*; D015820:Cadherins / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D019070:Cell Lineage / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006706:Homeostasis; D006801:Humans; D039001:Integrin alpha Chains / Q000276:immunology*; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology; D007801:Langerhans Cells / Q000276:immunology; D008168:Lung / Q000166:cytology / Q000276:immunology; D010581:Peyer's Patches / Q000166:cytology / Q000276:immunology; D015398:Signal Transduction; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D015703:Antigens, CD; D015820:Cadherins; D039001:Integrin alpha Chains; C091367:alpha E integrins