title: Reaction of isocyanides with thiophenols and gem-diactivated olefins: a one-pot synthesis of substituted 2-aminopyrroles.
abstract: A novel multicomponent reaction of isocyanides with thiophenols and gem-diactivated olefins has been discovered. Depending on the choice of isocyanides, substituted 2-aminopyrroles or thioimidates have been prepared. The obtained scaffolds bearing four points of diversity can directly be used in combinatorial syntheses.
authors.affiliation: Department of Technology for Organic Synthesis, TOSLab, Ural State Technical University, 620002 Ekaterinburg, Russian Federation.
authors.forename: Anna N
authors.initials: AN
authors.lastname: Kolontsova
authors.forename: Maria N
authors.initials: MN
authors.lastname: Ivantsova
authors.forename: Maria I
authors.initials: MI
authors.lastname: Tokareva
authors.forename: Maxim A
authors.initials: MA
authors.lastname: Mironov
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002625:Chemistry, Organic / Q000379:methods*; D003486:Cyanides / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D000475:Alkenes; D003486:Cyanides; D010636:Phenols; D011758:Pyrroles; D013438:Sulfhydryl Compounds; C042983:thiophenol