Pretransplant predictors of recovery of renal function after liver transplantation.
The Model for End-Stage Liver Disease system has given priority on the liver transplant waiting list to candidates with renal failure. This study determined the predictors of spontaneous recovery of renal function after transplantation in 1041 liver transplant recipients on renal replacement therapy (RRT) at the time of transplant (from February 2002 to January 2007). Data from these patients were obtained from the US Organ Procurement and Transplantation Network and US Renal Data System databases. Univariate and multivariate survival models were constructed along with multivariate logistic regression models to find independent predictors of spontaneous renal recovery. Seven hundred seven recipients (67.9%) had spontaneous recovery of renal function after liver transplantation. Those recovering spontaneously had a significantly shorter course of RRT in the pretransplant time period (15.6 versus 36.6 days, P < 0.001). Recovery of renal function was observed in 70.8% and 11.5% of recipients on RRT for less than 30 days and more than 90 days, respectively. Other statistically significant pretransplant variables independently associated with recovery of renal function included recipient age, recipient pretransplant diabetes, and donor age. In conclusion, the duration of pretransplant RRT is highly predictive of spontaneous renal recovery post-transplant. Liver transplant candidates requiring less than 30 days of pretransplant RRT are likely to spontaneously recover renal function after liver transplantation, whereas those on RRT for more than 90 days are not.
Northup
Patrick G
PG
Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, VA 22908-0708, USA. pgn5qs@virginia.edu
Argo
Curtis K
CK
Bakhru
Mihir R
MR
Schmitt
Timothy M
TM
Berg
Carl L
CL
Rosner
Mitchell H
MH
D000328:Adult; D000367:Age Factors; D000465:Algorithms; D005260:Female; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007674:Kidney Diseases / Q000209:etiology; D017093:Liver Failure / Q000628:therapy*; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D012042:Registries; D009927:Tissue and Organ Procurement; D016896:Treatment Outcome