[Associations of the genetic polymorphisms in CYP11B2 gene with nonfamilial structural atrial fibrillation].
OBJECTIVE
To investigate whether polymorphisms in CYP11B2 gene are associated with nonfamilial structural atrial fibrillation (AF) in Chinese Han population.


METHODS
A fine-designed pair-matched hospital based case-control study was performed in 297 cases and 297 controls. We investigated two tagging single nucleotide polymorphisms (tSNPs)-rs4545, rs3802228 in CYP11B2 gene by using GenomeLab SNPstream technique.


RESULTS
Two tSNPs were consistent with Hardy-Weinberg expectations in case and control groups. Compared with controls, the left atrial diameter of cases was significantly higher (P < 0.0001). No significant difference in genotype or allele frequencies of tSNPs in CYP11B2 gene was observed. However, at the site of rs3802228 in 3'UTR of the case group, the left atrial diameter in AF patients with GG genotype was significantly higher than others. After adjusted for covariates age, smoking, Body mass index and hypertension, we did not observe the association of rs4545, rs3802228 with AF.


CONCLUSIONS
Our result suggested that polymorphisms of rs4545 in CYP11B2 gene might not be associated with atrial fibrillation but polymorphism of 3'UTR rs3802228 locus in CYP11B2 gene might be associated with atrial structural remodeling.
Cao
Fei-fei
FF
Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan 250012, China.
Chen
Xing-dong
XD
Wang
Qun-shan
QS
Li
Lei
L
Wang
Xiao-feng
XF
Lu
Ming
M
Jin
Li
L
D044466:Asian People / Q000235:genetics*; D001281:Atrial Fibrillation / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006325:Heart Atria / Q000473:pathology; D006801:Humans; D020641:Polymorphism, Single Nucleotide
D019405:Cytochrome P-450 CYP11B2