title: Diagnostic esophago-gastro-duodenoscopy (EGD) in patients with AIDS-related upper gastrointestinal abnormalities.
abstract: OBJECTIVE
  Gastrointestinal (GI) diseases are common among patients infected with human immunodeficiency virus (HIV), and may involve the entire GI tract. The aim of the article is to investigate the prevalence of various upper gastrointestinal abnormalities in patients with AIDS.
  
  
  METHODS
  Diagnostic esophago-gastro-duodenoscopy (EGD) was performed in cohort of AIDS patients (total 186) including non-ART, mono and/or dual ART and HAART treated subgroups. Clinical presentation, level of immunosupression and presence of H. pylori infection was also considered.
  
  
  RESULTS
  Endoscopic findings included normal (29), esophageal candidiasis (22), esophageal erosions (16), gastritis/duodenitis (135), gastric/duodenal ulcers (7), erosions (6) and infiltration/tumor in the stomach (5). Thirty-nine patients (20.4%) had opportunistic infections/tumors including candida esophagitis, CMV esophagitis, CMV gastritis, gastric non-Hodgkin's lymphoma (NHL) and gastric cryptosporidiosis. H. pylori infection was present in 25.8% of patients, and majority (89.6%) had chronic non-atrophic gastritis. These patients had a higher mean CD4 count compared with H. pylori negative patients (403.5 vs. 226.9 CD4+ cells/microL, p = 0.001). Patients who received HAART had significantly higher frequency of H. pylori infection then non-ART treated patients (p = 0.048).
  
  
  CONCLUSIONS
  Candidiasis was the marker of advanced immunodeficiency, and H. pylori was more common in patients with higher CD4 cell counts on ART, which may suggest that this infection could be an unusual presentation of immune restoration inflammatory syndrome.
authors.affiliation: Institute for Infectious & Tropical Diseases, University of Belgrade School of Medicine, Belgrade, Serbia.
authors.forename: Milos
authors.initials: M
authors.lastname: Korać
authors.forename: Branko
authors.initials: B
authors.lastname: Brmbolić
authors.forename: Dubravka
authors.initials: D
authors.lastname: Salemović
authors.forename: Jovan
authors.initials: J
authors.lastname: Ranin
authors.forename: Zorica
authors.initials: Z
authors.lastname: Stojsić
authors.forename: Djordje
authors.initials: D
authors.lastname: Jevtović
authors.forename: Jelena
authors.initials: J
authors.lastname: Nikolić
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000293:Adolescent; D000328:Adult; D000368:Aged; D004384:Duodenoscopy; D004945:Esophagoscopy; D005260:Female; D005767:Gastrointestinal Diseases / Q000175:diagnosis* / Q000382:microbiology; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies