The interface between transcription and mechanisms maintaining genome integrity.
Maintaining genome integrity is crucial for correctly regulated gene expression. Conversely, the process of transcription fundamentally impinges on genome stability, necessitating cellular mechanisms that lessen the genome destabilizing effect of reading genes. This review provides an overview of our present knowledge of how eukaryotic RNA polymerase II transcription affects, and is affected by, other DNA-related processes such as chromatin remodeling, DNA repair, recombination and replication.
Svejstrup
Jesper Q
JQ
Clare Hall Laboratories, Cancer Research UK London Research Institute, Blanche Lane, South Mimms, EN6 3LD, UK. j.svejstrup@cancer.org.uk
D000818:Animals; D042002:Chromatin Assembly and Disassembly; D004260:DNA Repair; D042822:Genomic Instability; D006801:Humans; D009707:Nucleosomes / Q000378:metabolism; D010944:Plants / Q000235:genetics / Q000378:metabolism; D012319:RNA Polymerase II / Q000378:metabolism; D014158:Transcription, Genetic
D009707:Nucleosomes; D012319:RNA Polymerase II