title: [Structure and replication of viral hepatitis C virus, the key of the future therapeutic goals].
abstract: This paper reviews literature data on the hepatitis C virus. Hepatitis C virus is a positive-sense, single-stranded RNA virus. It is a genetically variable virus and it is estimated that the dominant viral sequence changes every few weeks. At least 6 genotypes are now recognized. All of this genotypes appear to have a similar effect on the liver but, the duration and response to therapy is strongly influenced by them. A complete understanding of this virus will greatly facilitate new antiviral agents.
authors.affiliation: Clinica a III-a Pediadrie, Facultatea de Medicină, Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi
authors.forename: Oana
authors.initials: O
authors.lastname: Grigorescu
authors.forename: Cătălina-Mihaela
authors.initials: CM
authors.lastname: Luca
authors.forename: Evelina
authors.initials: E
authors.lastname: Moraru
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D001483:Base Sequence; D005838:Genotype; D016174:Hepacivirus / Q000187:drug effects / Q000235:genetics* / Q000472:pathogenicity; D006526:Hepatitis C / Q000188:drug therapy; D006801:Humans; D012367:RNA, Viral / Q000235:genetics; D012324:RNA-Dependent RNA Polymerase / Q000235:genetics; D014779:Virus Replication / Q000235:genetics*
chemical_list: D000998:Antiviral Agents; D012367:RNA, Viral; D012324:RNA-Dependent RNA Polymerase