[Lipid frofile and hemorheology in obstructive sleep apnea-hypopnea syndrome.].
OBJECTIVE
To investigate whether there was a correlation between lipid level, hemorheology and the obstructive sleep apnea hypopnea syndrome.


METHODS
Two hundred and thirty-one subjects in our sleep respiratory disease center between 2006 and 2009 were included. Eighty nine were obese OSAHS subjects, 62 were non-obese OSAHS subjects, 40 were obese subjects without OSAHS (obese group) and 40 were non-obese subjects without OSAHS (control group). We examined and compared the lipid profile and hemorheology in all subjects.


RESULTS
In obese OSAHS group, the levels of triglyceride (TG) [(2.74 +/- 2.02) mmol/L], cholesterol (TC) [(5.14 +/- 0.96) mmol/L] were higher and HDL [(1.13 +/- 0.36) mmol/L], apoA-I [(1.20 +/- 0.20) mmol/L] were lower, compared to the non-obese OSAHS group (F = 7.77, 7.99, all P < 0.01). The level of the whole blood viscosity in obese OSAHS group was significantly higher than that in non-obese OSAHS group (F = 8.81-11.99, P < 0.05). There was no significant difference in blood lipid levels among the 2 study groups:non-obese OSAHS and control group, obese OSAHS and obese group (F = 6.42 - 11.99, P > 005). The levels of the whole blood viscosity and HCT were significantly higher in non-obese OSAHS group than in control group (F = 0.41 - 2.23, P < 0.05); obese OSAHS group were higher than obese group (F = 0.12 - 2.10, P < 0.05). No significant difference in blood lipid levels was noted among the 4 non-obese groups with different disease severity; similar result was also observed among obese OSAHS groups.


CONCLUSIONS
Obesity is responsible for dyslipidemia in OSAHS. OSAHS has no significant correlation with lipid abnormalities, but it significantly correlates with hemorheology disorder.
Ye
Liang
L
Department of Respiratory Medicine, Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200025, China.
Li
Min
M
Chen
Ling
L
Ma
Guan-Hua
GH
Li
Qing-Yun
QY
Ni
Jin-Hua
JH
Cao
Bei
B
Wan
Huan-Ying
HY
D018056:Hemorheology; D006801:Humans; D008055:Lipids; D009765:Obesity; D012890:Sleep; D020181:Sleep Apnea, Obstructive
D008055:Lipids