title: An unusual association: anti-Jo1 and anti-SRP antibodies in the serum of a patient with polymyositis.
abstract: The idiopathic inflammatory myopathies are systemic autoimmune diseases characterized by chronic inflammation, resulting in the progressive weakness of the proximal muscles. Myositis-specific or myositis-associated autoantibodies can often be found in serum of polymyositis and dermatomyositis patients. This autoantibody presence may play a significant role in patient diagnosis and classification. We present a female polymyositis patient characterized with serious muscle weakness and lung involvement. Anti-Jo1 antibodies were detected in the patient's serum at the time of diagnosis. After 5 years of treatment and surveillance, recent laboratory analysis showed the presence anti-SRP antibody in her serum.
authors.affiliation: Division of Immunology, 3rd Department of Internal Medicine, Institute for Internal Medicine, University of Debrecen Medical and Health Science Center, Moricz Zs. krt. 22, 4032, Debrecen, Hungary.
authors.forename: Melinda
authors.initials: M
authors.lastname: Vincze
authors.forename: Peter A
authors.initials: PA
authors.lastname: Molnár
authors.forename: Judit
authors.initials: J
authors.lastname: Tumpek
authors.forename: Lászlóné
authors.initials: L
authors.lastname: Szollosi
authors.forename: Agnes
authors.initials: A
authors.lastname: Gyetvai
authors.forename: Anikó
authors.initials: A
authors.lastname: Kapitány
authors.forename: Katalin
authors.initials: K
authors.lastname: Dankó
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D017285:Polymyositis / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D012346:RNA, Transfer, Amino Acyl; D018271:Signal Recognition Particle / Q000276:immunology
chemical_list: D001323:Autoantibodies; D012346:RNA, Transfer, Amino Acyl; D018271:Signal Recognition Particle