title: [Pharmacokinetics of fangchinoline and tetrandrine in rats].
abstract: OBJECTIVE
  To investigate the pharmacokinetics profile of fangchinoline and tetrandrine in rats after administration of single compound and mixture with other intergradient in traditional prescription.
  
  
  METHODS
  A method for determination of fangchinoline and tetrandrine in rat plasma by using HPLC-MS has been developed and validated. The pharmacokinetics of two compounds and two compounds in the effective component group (ECG) of Xiaoxuming decoction were compared.
  
  
  RESULTS
  Compared with the single dose of compound experiment results, the t(max) of fangchinoline and tetrandrine were longer than those in the single dose of ECG experiment. At the meanwhile the rest parameter showed no significant difference.
  
  
  CONCLUSIONS
  Other components in the ECG of Xiaoxuming decoction delayed the absorption rate of fangchinoline and tetrandrine, the bioavailability of two compounds were the same as that of the single dose of compound experiment.
authors.affiliation: Jiangsu Institute for Food and Drug Control, Nanjing 210008, China. lizhh402@sohu.com
authors.forename: Zhonghong
authors.initials: Z
authors.lastname: Li
authors.forename: Xialei
authors.initials: X
authors.lastname: Fan
authors.forename: Meiming
authors.initials: M
authors.lastname: Cai
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Ying
authors.forename: Guifen
authors.initials: G
authors.lastname: Qiang
authors.forename: Guanhua
authors.initials: G
authors.lastname: Du
mesh_terms: D000818:Animals; D044182:Benzylisoquinolines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D044182:Benzylisoquinolines; D004365:Drugs, Chinese Herbal; C009438:tetrandrine; C060802:fangchinoline