Forensic implications of genetic analyses from degraded DNA--a review.
Forensic DNA identification techniques are principally based on determination of the size or sequence of desired PCR products. The fragmentation of DNA templates or the structural modifications that can occur during the decomposition process can impact the outcomes of the analytical procedures. This study reviews the pathways involved in cell death and DNA decomposition and the subsequent difficulties these present in DNA analysis of degraded samples.
Alaeddini
Reza
R
School of Chemical and Biomolecular Engineering, University of Sydney, Sydney, Australia.
Walsh
Simon J
SJ
Abbas
Ali
A
D016923:Cell Death; D004247:DNA / Q000378:metabolism; D004249:DNA Damage; D053836:DNA Degradation, Necrotic; D016172:DNA Fingerprinting; D053938:DNA Fragmentation; D006801:Humans; D018384:Oxidative Stress; D016133:Polymerase Chain Reaction; D011180:Postmortem Changes
D004247:DNA