Oxime K027: novel low-toxic candidate for the universal reactivator of nerve agent- and pesticide-inhibited acetylcholinesterase.
Oxime K027 is a low-toxic bisquaternary compound originally developed as a reactivator of acetylcholinesterase (AChE) inhibited by nerve agents. The reactivation potency of K027 has been tested as a potential reactivator of AChE inhibited by tabun, sarin, cyclosarin, soman, VX, Russian VX, paraoxon, methylchlorpyrifos, and DDVP. The results show that oxime K027 reactivated AChE inhibited by almost all tested inhibitors to more than 10%, which is believed to be enough for saving the lives of intoxicated organisms. In the case of cyclosarin- and soman-inhibited AChE, oxime K027 did not reach sufficient reactivation potency.
Kuca
Kamil
K
Center of Advanced Studies, Faculty of Military Health Sciences, University of Defense, Trebesska, Hradec Kralove, Czech Republic. kucakam@pmfhk.cz
Musilek
Kamil
K
Jun
Daniel
D
Pohanka
Miroslav
M
Ghosh
Kallol Kumar
KK
Hrabinova
Martina
M
D000931:Antidotes / Q000494:pharmacology*; D002619:Chemical Warfare Agents / Q000633:toxicity; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D010091:Oximes / Q000494:pharmacology* / Q000627:therapeutic use; D010575:Pesticides / Q000633:toxicity; D011726:Pyridinium Compounds / Q000494:pharmacology* / Q000627:therapeutic use
C481758:1-(4-hydroxyiminomethylpyridinium)-3-(carbamoylpyridinium) propane dibromide; D000931:Antidotes; D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D002801:Cholinesterase Reactivators; D010091:Oximes; D010575:Pesticides; D011726:Pyridinium Compounds