title: Brainstem lesion in benign paroxysmal vertigo children: Evaluated by a combined ocular and cervical vestibular-evoked myogenic potential test.
abstract: OBJECTIVE
  This study utilized a combined ocular vestibular-evoked myogenic potential (oVEMP) and cervical VEMP (cVEMP) test in children with benign paroxysmal vertigo (BPV) to investigate whether the upper or lower brainstem is more frequently affected in BPV children.
  
  
  METHODS
  Fifteen BPV children aged 4-14 years, and 15 age- and sex-matched healthy children were enrolled. All subjects underwent pure tone audiometry, stabilometry, and a combined oVEMP and cVEMP test using acoustic stimulation.
  
  
  RESULTS
  All BPV patients displayed normal hearing and clear oVEMPs. However, 11 (73%) of 15 BPV patients had delayed cVEMPs, showing significant difference when compared with 100% normal cVEMPs in healthy children. The sway path and sway area in stabilometry were significantly different between BPV and healthy children, regardless of whether their eyes were open or closed. However, neither the sway path nor sway area correlated significantly with cVEMP results.
  
  
  CONCLUSIONS
  Normal oVEMPs in BPV children indicate an intact vestibulo-ocular reflex pathway, which travels through the upper brainstem. In contrast, delayed cVEMPs in BPV children reflect a retrolabyrinthine lesion along the sacculo-collic reflex pathway, which descends via the lower brainstem. Hence, the lower brainstem is more frequently affected than the upper brainstem in children with BPV.
authors.affiliation: Department of Otolaryngology, National Taiwan University Hospital, 1 Chang-te Street, Taipei, Taiwan.
authors.forename: Kuei-You
authors.initials: KY
authors.lastname: Lin
authors.forename: Ying-Shuo
authors.initials: YS
authors.lastname: Hsu
authors.forename: Yi-Ho
authors.initials: YH
authors.lastname: Young
mesh_terms: D000161:Acoustic Stimulation; D001301:Audiometry, Pure-Tone; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004576:Electromyography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011434:Proprioception / Q000502:physiology; D012027:Reflex, Vestibulo-Ocular / Q000502:physiology; D014717:Vertigo / Q000503:physiopathology*; D014724:Vestibular Function Tests