Loteprednol and tobramycin in combination: a review of their impact on current treatment regimens.
BACKGROUND
The treatment of ocular inflammation continues to be a challenge. Topical corticosteroids are effective in reducing ocular inflammation but are limited by adverse events including elevation of intraocular pressure, development of cataracts, glaucoma and inhibition of wound healing with associated risk of infection. Loteprednol etabonate (LE) is a unique C-20 ester corticosteroid designed to produce a predictable therapeutic effect with a low incidence of side effects. Zylet (LE/T) a combination of LE and tobramycin (T) is indicated for the treatment of steroid-responsive ocular inflammatory conditions in which there exists either superficial bacterial ocular infection or a potential risk of bacterial infection.


METHODS
The current review of the literature (Medline and the Cochrane Library, 1996 - 2009) examines the safety and efficacy of LE/T in the treatment of ocular inflammation.


RESULTS
Studies with either LE or LE/T indicate that LE has a lower risk of IOP elevation compared with C-20 ketone corticosteroids owing to its rapid de-esterification to inactive metabolites. LE also lacks the ability to form Schiff base intermediates with lens proteins, a common first step in cataractogenesis. LE/T was noninferior to dexamethasone 0.1%/tobramycin 0.3% in the treatment of blepharokeratoconjunctivitis.


CONCLUSIONS
LE/T may be a safer treatment option for ocular inflammation in which there is risk of superficial bacterial infections.
Comstock
Timothy L
TL
Bausch & Lomb Incorporated, Rochester, 1400 North Goodman Street, Rochester, NY 1460, USA. tcomstock@bausch.com
Holland
Edward J
EJ
D000287:Administration, Topical; D000730:Androstadienes / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D018926:Anti-Allergic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D005128:Eye Diseases / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D007429:Intraocular Pressure / Q000187:drug effects; D000069559:Loteprednol Etabonate; D009883:Ophthalmic Solutions; D014031:Tobramycin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D000730:Androstadienes; D018926:Anti-Allergic Agents; D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D009883:Ophthalmic Solutions; D014031:Tobramycin; D000069559:Loteprednol Etabonate