title: [Effect of postoperative pregnancy upon prognosis of young breast cancer patients].
abstract: OBJECTIVE
  To examine the effect of postoperative pregnancy upon the prognosis of young Chinese breast cancer patients.
  
  
  METHODS
  Four hundred and thirty-two female unilateral breast cancer patients aged 35 or younger were retrospectively reviewed. Kaplan-Meier analysis and Log Rank test were used for univariate analysis of factors predictive of disease-free survival (DFS) and overall survival (OS). Multivariate analysis was carried out using the Cox proportional hazards model.
  
  
  RESULTS
  Eighteen patients were identified to have postoperative pregnancy, including 5 full-term pregnancy and 13 abortions with the earliest pregnancy taking place at Month 17 post-operation. After a median follow-up of 62 months (6 - 237 months), the DFS and OS rates were 72.5% (313/432) and 88.7% (383/432) respectively. On multivariate analysis, postoperative pregnancy, clinical stage and number of pathologically involved axillary lymph node were significantly associated with DFS. And the axillary lymph node status was also predictive of OS. No death occurred in patient with postoperative pregnancy. There was no significant association between postoperative pregnancy and OS.
  
  
  CONCLUSIONS
  Postoperative pregnancy has no adverse effect upon the prognosis of young breast cancer patients.
authors.affiliation: Department of Breast Surgery, Cancer Hospital, Fudan University, Shanghai 200032, China.
authors.forename: Jia-yi
authors.initials: JY
authors.lastname: Wu
authors.forename: Can-ming
authors.initials: CM
authors.lastname: Chen
authors.forename: Jia-xin
authors.initials: JX
authors.lastname: Zhang
authors.forename: Yi-feng
authors.initials: YF
authors.lastname: Hou
authors.forename: Zhen
authors.initials: Z
authors.lastname: Hu
authors.forename: Guang-yu
authors.initials: GY
authors.lastname: Liu
authors.forename: Gen-hong
authors.initials: GH
authors.lastname: Di
authors.forename: Jiong
authors.initials: J
authors.lastname: Wu
authors.forename: Jin-song
authors.initials: JS
authors.lastname: Lu
authors.forename: Kun-wei
authors.initials: KW
authors.lastname: Shen
authors.forename: Zhi-min
authors.initials: ZM
authors.lastname: Shao
authors.forename: Zhen-zhou
authors.initials: ZZ
authors.lastname: Shen
mesh_terms: D000328:Adult; D000367:Age Factors; D001943:Breast Neoplasms / Q000401:mortality* / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology*; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011184:Postoperative Period; D011247:Pregnancy; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D015996:Survival Rate