Reactivation potency of the acetylcholinesterase reactivator obidoxime is limited.
BACKGROUND
Obidoxime is the only one reactivator of acetylcholinesterase (AChE) approved in Czech Republic for the treatment of nerve agent and pesticide poisonings for civilian sector. Due to the fact that misuse of nerve agents by terrorists or by an accidental poisoning by farmers is possible, re-evaluation of its universality is needed. It is also needed by the fact that clinical findings considering this oxime are controversial.


OBJECTIVE
In this study, we wanted to summarize if obidoxime is a universal reactivator or if its reactivation potency in case of some organophosphorus inhibitors is limited.


METHODS
Using our in vitro method, rat brain AChE was inhibited by eleven organophosphorus AChE inhibitors and then reactivated by obidoxime.


CONCLUSIONS
It was found that obidoxime could not be termed as universal antidote. Due to this, development of new promising candidates as replacement of obidoxime is recommended.
Kuca
Kamil
K
Center of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic. kucakam@pmfhk.cz
Musilek
Kamil
K
Pohanka
Miroslav
M
Dohnal
Vlastimil
V
Patocka
Jiri
J
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D000931:Antidotes / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D002619:Chemical Warfare Agents / Q000506:poisoning*; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D066298:In Vitro Techniques; D009768:Obidoxime Chloride / Q000494:pharmacology*; D010575:Pesticides / Q000506:poisoning*; D051381:Rats
D000931:Antidotes; D002619:Chemical Warfare Agents; D002801:Cholinesterase Reactivators; D010575:Pesticides; D009768:Obidoxime Chloride; D000110:Acetylcholinesterase