Altered hyaluronan biosynthesis and cancer progression: an immunological perspective.
Hyaluronan is a glycosaminglycan present in practically all tissues as an important component of the extracellular matrix. In spite of its apparent simple chemical structure, hyaluronan is a molecule with multiple and complex physiogical and pathological functions, Hyaluronan is able to regulate a variety of biological processes such as cellular growth, migration, differentiation and inflammation, not only in normal but also in cancer tissues. Besides, increasing evidence suggests hyaluronan as a potent modulator of immune responses which supports a potential role of this molecule in cancer immunotherapy.
Alaniz
Laura
L
Gene Therapy Laboratory, School of Medicine, Austral University, Avenida Presidente Perón 1500 (B1629ODT) Derqui-Pilar, Buenos Aires, Argentina.
Garcia
Mariana
M
Rizzo
Miguel
M
Piccioni
Flavia
F
Mazzolini
Guillermo
G
D018450:Disease Progression; D006801:Humans; D006820:Hyaluronic Acid / Q000096:biosynthesis* / Q000502:physiology; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology
D006820:Hyaluronic Acid