Microbe-dendritic cell dialog controls regulatory T-cell fate.
Each microenvironment is controlled by a specific set of regulatory elements that have to be finely and constantly tuned to maintain local homeostasis. These environments could be site specific, such as the gut environment, or induced by chronic exposure to microbes. Various populations of dendritic cells are central to the orchestration of this control. In this review, we discuss some new findings associating dendritic cells from defined compartments with the induction and control of regulatory T cells in the context of exposure to both commensal and pathogenic microbes.
Grainger
John R
JR
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20894, USA.
Hall
Jason A
JA
Bouladoux
Nicolas
N
Oldenhove
Guillaume
G
Belkaid
Yasmine
Y
D000818:Animals; D001419:Bacteria / Q000276:immunology*; D002454:Cell Differentiation / Q000276:immunology; D019070:Cell Lineage / Q000276:immunology; D003141:Communicable Diseases / Q000276:immunology / Q000382:microbiology / Q000469:parasitology; D003713:Dendritic Cells / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology; D051858:Forkhead Transcription Factors / Q000276:immunology; D006706:Homeostasis; D006790:Host-Parasite Interactions; D054884:Host-Pathogen Interactions; D006801:Humans; D007410:Intestinal Diseases / Q000276:immunology / Q000382:microbiology / Q000469:parasitology; D007422:Intestines / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology; D010271:Parasites / Q000276:immunology*; D010581:Peyer's Patches / Q000276:immunology / Q000382:microbiology / Q000469:parasitology; D015398:Signal Transduction; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000382:microbiology / Q000469:parasitology
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors