Athletes, NSAID, coxibs, and the gastrointestinal tract.
The role of nonsteroidal antiinflammatory drugs (NSAID) in pain and inflammation has been evaluated in many forms over the last decade. Emerging evidence shows that this class of medications has different effects depending on injury type: bone, ligament, tendon, and muscle. There are no clear guidelines about specific NSAID choice, duration of use, or route of administration. Benefit of therapy must be weighed against the side effects of NSAID, specifically with respect to the gastrointestinal and renal systems. It is clear that the side effect profile changes within the subclasses of NSAID, nonspecific cyclo-oxygenase-1 and 2 (COX-1 and COX-2) inhibitors, and more selective COX-2 inhibitors. Safe and effective alternatives may include topical NSAID and acetaminophen.
Lilly
Katy Fader
KF
Woodbury Family Practice, Newington, NH 03801, USA. katylilly@comcast.net
D000082:Acetaminophen / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D056352:Athletes; D001265:Athletic Injuries / Q000188:drug therapy; D052246:Cyclooxygenase 2 Inhibitors / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D041981:Gastrointestinal Tract / Q000187:drug effects*; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced; D007668:Kidney / Q000187:drug effects; D007676:Kidney Failure, Chronic / Q000139:chemically induced
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D000082:Acetaminophen