Protein mediators of sterol transport across intestinal brush border membrane.
Dysregulation of cholesterol balance contributes significantly to atherosclerotic cardiovascular disease (ASCVD), the leading cause of death in the United States. The intestine has the unique capability to act as a gatekeeper for entry of cholesterol into the body, and inhibition of intestinal cholesterol absorption is now widely regarded as an attractive non-statin therapeutic strategy for ASCVD prevention. In this chapter we discuss the current state of knowledge regarding sterol transport across the intestinal brush border membrane. The purpose of this work is to summarize substantial progress made in the last decade in regards to protein-mediated sterol trafficking, and to discuss this in the context of human disease.
Brown
J Mark
JM
Department of Pathology Section on Lipid Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Yu
Liqing
L
D000071018:ATP Binding Cassette Transporter, Subfamily G, Member 5; D000071019:ATP Binding Cassette Transporter, Subfamily G, Member 8; D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000502:physiology; D000818:Animals; D001384:Azetidines / Q000494:pharmacology; D002784:Cholesterol / Q000378:metabolism*; D000069438:Ezetimibe; D005786:Gene Expression Regulation; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology; D008074:Lipoproteins / Q000235:genetics / Q000502:physiology; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D026901:Membrane Transport Proteins; D008871:Microvilli / Q000378:metabolism*; D023421:Models, Animal; D051122:Scavenger Receptors, Class B / Q000235:genetics / Q000502:physiology
C416945:ABCG5 protein, human; C416946:ABCG8 protein, human; D000071018:ATP Binding Cassette Transporter, Subfamily G, Member 5; D000071019:ATP Binding Cassette Transporter, Subfamily G, Member 8; D018528:ATP-Binding Cassette Transporters; D001384:Azetidines; D047908:Intracellular Signaling Peptides and Proteins; D008074:Lipoproteins; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; C410800:NPC1L1 protein, human; C495124:SCARB1 protein, human; C102196:SREBP cleavage-activating protein; D051122:Scavenger Receptors, Class B; D002784:Cholesterol; D000069438:Ezetimibe