title: Polymorphisms of the gamma-glutamyl hydrolase gene and risk of relapse to acute lymphoblastic leukemia in Mexico.
abstract: This study evaluated the association of -401C/T and +452C/T polymorphisms of gamma-glutamyl hydrolase and the risk of relapse to acute lymphoblastic leukemia. Genotyping was performed in 70 children with acute lymphoblastic leukemia and 140 healthy children. An association between the -401C/T polymorphism and the risk of relapse was found (p=0.028), patients with the -401T/T genotype have 10.83 (95% CI 1.30-90.14) more chance of a relapse of leukemia. No association was found between the +452C/T polymorphism and the risk of relapse. Therefore, our investigation suggests that the -401C/T polymorphism in the gamma-glutamyl hydrolase may be a factor involved in the generation of relapse to disease in patients with ALL.
authors.affiliation: Laboratorio de Biomedicina Molecular, Unidad Académica de Ciencias Químico Biológicas, Universidad Autónoma de Guerrero, Ciudad Universitaria, Chilpancingo, Guerrero, Mexico.
authors.forename: Jorge
authors.initials: J
authors.lastname: Organista-Nava
authors.forename: Yazmín
authors.initials: Y
authors.lastname: Gómez-Gómez
authors.forename: Mónica Virginia
authors.initials: MV
authors.lastname: Saavedra-Herrera
authors.forename: Ana Bertha
authors.initials: AB
authors.lastname: Rivera-Ramírez
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Terán-Porcayo
authors.forename: Luz Del Carmen
authors.initials: Ldel C
authors.lastname: Alarcón-Romero
authors.forename: Berenice
authors.initials: B
authors.lastname: Illades-Aguiar
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Leyva-Vázquez
mesh_terms: D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use; D008800:Mexico; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D012008:Recurrence; D012306:Risk; D016896:Treatment Outcome; D011623:gamma-Glutamyl Hydrolase / Q000235:genetics*
chemical_list: D000964:Antimetabolites, Antineoplastic; D011623:gamma-Glutamyl Hydrolase; D008727:Methotrexate