title: N-(tert)-butyloxycarbonyl)-beta,beta-cyclopentyl-cysteine (acetamidomethyl)-methyl ester for synthesis of novel peptidomimetic derivatives.
abstract: It has been recently reported that thiol groups could play an important role in the protection of neuronal cells in Alzheimer's disease (AD), prion disease (CJD) and Parkinson's disease (PD). Also bucillamine, that is a pseudo dipeptide possessing a thiol group capable to form an internal disulfide bridge, has relevant scavenger properties used in therapy for the treatment of arthritis. Furthermore, many sulphur containing compounds show strong chelating properties to heavy metals. Due to the crucial role of thiol groups in a variety of detoxicant biological systems, we report the synthesis of a racemic beta,beta-dialkyl-substituted, fully protected, cysteine derivative as a suitable intermediate in the synthesis of novel biological active peptides.
authors.affiliation: Dipartimento di Scienze del Farmaco, Università di Chieti-Pescara G. d'Annunzio, Via dei Vestini 31, 66100 Chieti, Italy. a.mollica@unich.it
authors.forename: Adriano
authors.initials: A
authors.lastname: Mollica
authors.forename: Federica
authors.initials: F
authors.lastname: Feliciani
authors.forename: Azzurra
authors.initials: A
authors.lastname: Stefanucci
authors.forename: Ivana
authors.initials: I
authors.lastname: Cacciatore
authors.forename: Catia
authors.initials: C
authors.lastname: Cornacchia
authors.forename: Domenica
authors.initials: D
authors.lastname: Torino
authors.forename: Francesco
authors.initials: F
authors.lastname: Pinnen
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry; D003517:Cyclopentanes / Q000737:chemistry; D003545:Cysteine / Q000031:analogs & derivatives / Q000737:chemistry; D005663:Furans / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D017670:Sodium Compounds / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D003517:Cyclopentanes; D005663:Furans; D010455:Peptides; D017670:Sodium Compounds; D013438:Sulfhydryl Compounds; C524957:sodium hydride; C018674:tetrahydrofuran; D003545:Cysteine; C026535:bucillamine