title: Palladium-catalyzed direct oxidation of alkenes with molecular oxygen: general and practical methods for the preparation of 1,2-diols, aldehydes, and ketones.
abstract: 1,2-Diols, aldehydes, and ketones are important intermediates in chemical synthesis, and alkenes are possible precursors for 1,2-diols, aldehydes, and ketones. Herein, novel and environmentally benign methods for palladium-catalyzed dihydroxylation and oxidative cleavage of olefins with oxygen as sole oxidant are presented. The cleavage reactions were performed with acid as additive in aqueous solution, whereas 1,2-diols were formed in the presence of base. A broad substrate scope has been demonstrated allowing monosubstituted aromatic and aliphatic terminal alkenes, 1,2-disubstituted, and 1,1-disubstituted olefins. The cleavage reactions of dioxo-Pd(II) complexes implicate 1,2-diol might act as a key intermediate of olefin cleavage.
authors.affiliation: School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, People's Republic of China.
authors.forename: Azhong
authors.initials: A
authors.lastname: Wang
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang