title: Adipokines and cardiometabolic profile in primary hyperaldosteronism.
abstract: BACKGROUND
  Primary aldosteronism (PA) has been recently associated with an unfavorable cardiometabolic profile. However, whether pro- and antiinflammatory adipokines levels can vary in PA is unknown.
  
  
  OBJECTIVE
  We evaluated the circulating levels of resistin, leptin, and adiponectin, echocardiographic left ventricle (LV) parameters, and the prevalence of metabolic syndrome (SM) in subjects with PA.
  
  
  METHODS
  Seventy-five subjects with established diagnosis of PA and 232 consecutive individuals with known or suspected hypertension were enrolled.
  
  
  METHODS
  Plasma adipokine levels and echocardiographic parameters were calculated. Prevalence of SM was also estimated.
  
  
  RESULTS
  Among the 75 PA subjects, 37 patients were affected by aldosterone-producing adenoma and 38 by idiopathic hyperaldosteronism; 40 subjects were affected by essential hypertension (EH) and SM (EH SM+); 152 subjects were affected by EH without SM (EH SM-); and 40 subjects were normotensive (NT). Subjects with PA had the highest plasma resistin levels among the four groups (P < 0.01). Plasma resistin concentration was significantly higher in PA subjects when compared with EH SM+ individuals (P < 0.01) and EH SM- subjects (P < 0.01). PA subjects showed the higher LV mass and left atrium than EH individuals, irrespectively of the presence of SM (P < 0.01 for both). Plasma resistin levels was significantly correlated with ejection fraction and LV end-diastolic volume. The prevalence of SM was higher in PA subjects than in those with EH (25.4 vs. 20.3%).
  
  
  CONCLUSIONS
  Our data suggest that elevated aldosterone levels is associated with elevated circulating resistin levels and cardiac morphological changes independently of the presence of SM.
authors.affiliation: Division of Endocrinology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada. gianluca@ccc.mcmaster.ca
authors.forename: Gianluca
authors.initials: G
authors.lastname: Iacobellis
authors.forename: Luigi
authors.initials: L
authors.lastname: Petramala
authors.forename: Dario
authors.initials: D
authors.lastname: Cotesta
authors.forename: Mario
authors.initials: M
authors.lastname: Pergolini
authors.forename: Laura
authors.initials: L
authors.lastname: Zinnamosca
authors.forename: Rosario
authors.initials: R
authors.lastname: Cianci
authors.forename: Giorgio
authors.initials: G
authors.lastname: De Toma
authors.forename: Susanna
authors.initials: S
authors.lastname: Sciomer
authors.forename: Claudio
authors.initials: C
authors.lastname: Letizia
mesh_terms: D000236:Adenoma / Q000150:complications / Q000378:metabolism; D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood* / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002097:C-Reactive Protein / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood* / Q000150:complications / Q000000981:diagnostic imaging; D006973:Hypertension / Q000150:complications; D020738:Leptin / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications; D008875:Middle Aged; D052243:Resistin / Q000097:blood*; D055815:Young Adult
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D020738:Leptin; D052243:Resistin; D000450:Aldosterone; D002097:C-Reactive Protein; D002784:Cholesterol