title: Association of pericoronary fat volume with atherosclerotic plaque burden in the underlying coronary artery: a segment analysis.
abstract: OBJECTIVE
  We aimed to determine, whether the amount of local pericoronary fat volume is associated with the presence of plaque burden in the underlying coronary artery segment.
  
  
  METHODS
  We assessed 311 coronary segments from ECG-gated contrast-enhanced dual-source computed tomography for presence of plaque as well as segmental pericoronary fat volume. For pericoronary fat evaluation, regions of interest were manually traced containing any fat surrounding a coronary artery segment, with the myocardial wall, the pericardial sac and other coronary segments as outer border.
  
  
  RESULTS
  Per each doubling of pericoronary fat volume, we observed an 2.5-fold increase in the presence of plaque in the underlying coronary segment in unadjusted models (95% confidence interval [CI] 1.87-3.27, p<0.001), which remained after adjustment for traditional cardiovascular risk factors (odds ratio [OR] 3.07 [2.16-4.35], p<0.001) and when additionally accounting for overall pericardial fat volume (OR 2.68 [1.90-3.79], p<0.001). Associations were similar in all coronary artery segments and not related to the type of plaque (calcified or non-calcified, p<0.01 for all).
  
  
  CONCLUSIONS
  Pericoronary fat is associated with atherosclerosis in the coronary arteries. Our results support the hypothesis that perivascular fat depots may function as a local endocrine risk factor in atherosclerosis development.
authors.affiliation: West German Heart Center, Department of Cardiology, University Clinic Essen, Hufelandstrasse 55, 45147 Essen, Germany.
authors.forename: Amir A
authors.initials: AA
authors.lastname: Mahabadi
authors.forename: Nico
authors.initials: N
authors.lastname: Reinsch
authors.forename: Nils
authors.initials: N
authors.lastname: Lehmann
authors.forename: Jens
authors.initials: J
authors.lastname: Altenbernd
authors.forename: Hagen
authors.initials: H
authors.lastname: Kälsch
authors.forename: Rainer M
authors.initials: RM
authors.lastname: Seibel
authors.forename: Raimund
authors.initials: R
authors.lastname: Erbel
authors.forename: Stefan
authors.initials: S
authors.lastname: Möhlenkamp
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging* / Q000473:pathology; D000368:Aged; D050197:Atherosclerosis / Q000000981:diagnostic imaging* / Q000473:pathology; D002114:Calcinosis / Q000150:complications; D002318:Cardiovascular Diseases / Q000150:complications; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000000981:diagnostic imaging / Q000473:pathology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods