title: Titanium and strontium-doped phosphate glasses as vehicles for strontium ion delivery to cells.
abstract: This study investigated the use of a Ti-containing quaternary phosphate glass system P(2)O(5)-Na(2)O-CaO-TiO(2) as a vehicle for strontium ion delivery to cells. Four glass compositions were manufactured: 0.5P(2)O(5)-0.15Na(2)O-0.05TiO(2)-(0.3 - x)CaO-xSrO (x = 0, 0.01, 0.03, and 0.05). Structural characterization revealed that sodium calcium phosphate is the dominant phase in all the glasses. Degradation studies demonstrated highly linear glass degradation, with Sr-containing glasses degrading at higher rates than the Sr-free glass. Biocompatibility studies using MG63 cells showed that the Sr-containing glasses possess excellent cell attachment and growth, particularly over short periods (~4 days).
authors.affiliation: University College London, Eastman Dental Institute, London, UK. nilay.lak@gmail.com
authors.forename: Nilay
authors.initials: N
authors.lastname: Lakhkar
authors.forename: Ensanya A
authors.initials: EA
authors.lastname: Abou Neel
authors.forename: Vehid
authors.initials: V
authors.lastname: Salih
authors.forename: Jonathan Campbell
authors.initials: JC
authors.lastname: Knowles
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002448:Cell Adhesion; D002460:Cell Line; D049109:Cell Proliferation; D004337:Drug Carriers / Q000737:chemistry*; D005898:Glass / Q000737:chemistry*; D006801:Humans; D007477:Ions / Q000737:chemistry; D008422:Materials Testing; D010087:Oxides / Q000737:chemistry; D014677:Pharmaceutical Vehicles / Q000737:chemistry*; D013324:Strontium / Q000008:administration & dosage* / Q000737:chemistry*; D013499:Surface Properties; D014025:Titanium / Q000737:chemistry*; D014961:X-Ray Diffraction / Q000379:methods
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D007477:Ions; D010087:Oxides; D014677:Pharmaceutical Vehicles; C118163:sodium oxide-calcium oxide-diphosphorus pentoxide glass; C009495:titanium dioxide; D014025:Titanium; D013324:Strontium