title: Does the effect of morphine challenge change on maternal behaviour of dams chronically treated with morphine during gestation and further on during lactation?
abstract: Opioids impair the maternal behaviour of rats. The effect of morphine on maternal behaviour in dams treated chronically with morphine during the whole pregnancy and lactation has not been analysed systematically. The aim of the present study was to investigate the possible differences in the disruptive effect of morphine on maternal behaviour following morphine challenges between dams treated chronically with saline or morphine during gestation and postpartum. The antinociceptive action of morphine was also studied in dams. The disruptive effect of morphine on maternal behaviour was not changed as the postpartum period passed. The duration of this effect of morphine lasted for about 2h. The dose-dependent disruptive effect of acute doses of morphine on maternal behaviour was more marked in the morphine-treated dams, than in the saline-treated ones, indicating a tendency for sensitisation to this effect. A trend for tolerance was observed to the antinociceptive effect of morphine in animals treated daily with morphine during the entire gestational and lactation periods; however, this difference did not reach statistical significance. Our experimental protocol might be a predictive model of human opioid abuse. Sensitisation to the impairing effect of opiates on maternal behaviour may explain why a mother abusing heroin neglects her baby even if she does not experience euphoria.
authors.affiliation: National Institute of Pharmacy, Zrínyi u. 3, 1051 Budapest, Hungary. sobor.melinda@ogyi.hu
authors.forename: Melinda
authors.initials: M
authors.lastname: Sobor
authors.forename: Julia
authors.initials: J
authors.lastname: Timár
authors.forename: Pal
authors.initials: P
authors.lastname: Riba
authors.forename: Kornél P
authors.initials: KP
authors.lastname: Király
authors.forename: Susanna
authors.initials: S
authors.lastname: Gyarmati
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Al-Khrasani
authors.forename: Susanna
authors.initials: S
authors.lastname: Fürst
mesh_terms: D000818:Animals; D005260:Female; D007774:Lactation / Q000187:drug effects* / Q000502:physiology / Q000523:psychology; D008297:Male; D008425:Maternal Behavior / Q000187:drug effects* / Q000502:physiology / Q000523:psychology; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects* / Q000502:physiology / Q000523:psychology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D009020:Morphine