title: Saline nebulization before gastric lavage in the diagnosis of pulmonary tuberculosis in children and adolescents.
abstract: The main objective is to assess whether nebulization before gastric lavage (GL) improves its sensitivity for the diagnosis of childhood tuberculosis (TB). Children and adolescents suspected of pulmonary TB were randomly assigned (1 : 2) to nebulization with hypertonic saline 30 min before GL (Neb group; n = 36) or GL without prior nebulization (controls; n = 68). The proportion of positive GL smears was greater in Neb group than in the control group; however, no statistical significance was observed (36.3% vs. 22.2%; p = 0.4). Inhalation of nebulized hypertonic saline before GL did not improve TB diagnosis in this study. Nevertheless, the validation of our data will require large longitudinal studies.
authors.forename: Ethel Leonor
authors.initials: EL
authors.lastname: Maciel
authors.forename: Renata Lyrio
authors.initials: RL
authors.lastname: Peres
authors.forename: Thiago Nascimento
authors.initials: TN
authors.lastname: do Prado
authors.forename: Cristina Ribeiro
authors.initials: CR
authors.lastname: Macedo
authors.forename: Moisés
authors.initials: M
authors.lastname: Palaci
authors.forename: Solange Alves
authors.initials: SA
authors.lastname: Vinhas
authors.forename: Reynaldo
authors.initials: R
authors.lastname: Dietze
authors.forename: John L
authors.initials: JL
authors.lastname: Johnson
authors.forename: Claúdio Jose
authors.initials: CJ
authors.lastname: Struchiner
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D005751:Gastric Lavage; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D009330:Nebulizers and Vaporizers; D012462:Saline Solution, Hypertonic; D012680:Sensitivity and Specificity; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis* / Q000382:microbiology
chemical_list: D012462:Saline Solution, Hypertonic