title: [Association between the erythrocyte sedimentation rate, serum C-reactive protein and risk of lung cancer].
abstract: OBJECTIVE
  To explore the association between the erythrocyte sedimentation rate, serum C-reactive protein (CRP) and the risk of lung cancer.
  
  
  METHODS
  One hundred and three patients with newly diagnosed lung cancer and 85 homochronous hospitalized patients with chronic respiratory diseases (including chronic obstructive pulmonary disease, asthma, bronchiectasis and pulmonary fibrosis) were included in this study. ESR, serum levels of CRP, CEA, CA19-9 and CA125 were analyzed in the two groups before the initiation of any therapy after hospitalization. The association with clinicopathological characteristics of lung cancer and the risk of lung cancer were estimated by logistic regression.
  
  
  RESULTS
  Both the ESR and CRP levels were significantly higher in the lung cancer group, as compared with that in the chronic respiratory diseases group (P < 0.001). There was no significant association of ESR and CRP with lung cancer stage and type. Spearman correlation analysis showed a positive correlation between ESR and CRP (r = 0.56, P < 0.001), ESR and CA125 (r = 0.33, P < 0.001), and CRP and CA125 (r = 0.32, P < 0.001). The results of multivariate logistic analysis showed that the level of CRP was associated with an increased risk of lung cancer. Adjusting the confounding factors such as age, gender and smoking condition, the risk increased along with the elevation of CRP. Compared with the first quantile patients, the risk of the second quantile patients increased twice (OR: 2.46, 95%CI: 1.16 - 5.20), the risk of the third quantile patients increased ten-fold (OR: 10.52, 95%CI: 4.40 - 25.18).
  
  
  CONCLUSIONS
  The level of CRP is associated with an increased risk of lung cancer. The results of this study suggest that early detection of CRP may have a potential predicting value for high risk group of lung cancer.
authors.affiliation: Beijing Institute of Respiratory Diseases, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China. zhangyhcy@163.com
authors.forename: Yu-hui
authors.initials: YH
authors.lastname: Zhang
authors.forename: Li-juan
authors.initials: LJ
authors.lastname: Guo
authors.forename: Tu-guang
authors.initials: TG
authors.lastname: Kuang
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.forename: Li-rong
authors.initials: LR
authors.lastname: Liang
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000378:metabolism; D000328:Adult; D000368:Aged; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism*; D018394:CA-125 Antigen / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000378:metabolism; D002908:Chronic Disease; D005260:Female; D006801:Humans; D016015:Logistic Models; D008171:Lung Diseases / Q000097:blood / Q000378:metabolism; D008175:Lung Neoplasms / Q000097:blood* / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D008875:Middle Aged; D009367:Neoplasm Staging; D012307:Risk Factors; D055752:Small Cell Lung Carcinoma / Q000097:blood / Q000378:metabolism
chemical_list: D018394:CA-125 Antigen; D002272:Carcinoembryonic Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins; D002097:C-Reactive Protein