title: Age-related macular degeneration: current and novel therapies.
abstract: Age-related macular degeneration (AMD) is a leading cause of vision loss in people over the age of 60 with a prevalence that continues to rise, particularly in industrialized nations. Although treatments for AMD were once limited, with disappointing clinical results, new treatments have emerged for both the nonexudative and exudative forms of the disease, which have improved prognostic outcomes. These treatments include nutritional supplementation, antioxidant prophylaxis, and intravitreal injection of medications that inhibit aberrant vascular proliferation. This review serves as a summary of the current and experimental therapies for both exudative and nonexudative AMD. Although a number of challenges and clinical questions remain, the future of treating AMD appears promising particularly as we gain further insights into the genetic and biochemical pathways of the disease.
authors.affiliation: Department of Ophthalmology, David Geffen School of Medicine at University of California, Los Angeles, CA 90095-7000, USA.
authors.forename: Pradeep S
authors.initials: PS
authors.lastname: Prasad
authors.forename: Steven D
authors.initials: SD
authors.lastname: Schwartz
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Hubschman
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D019587:Dietary Supplements; D006801:Humans; D008268:Macular Degeneration / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D010778:Photochemotherapy; D014822:Vitreous Body
chemical_list: D000975:Antioxidants