A new insulin-enhancing agent: [N,N'-bis(4-hydroxysalicylidene)-o-phenylene-diamine]oxovanadium(IV) and its permeability and cytotoxicity.
A new insulin-enhancing agent: [N,N'-bis(4-hydroxysalicylidene)-o-phenylene-diamine] oxovanadium(IV) (BPOV) was synthesized and characterized by X-ray crystallography. BPOV was administered intragastrically to STZ-diabetic rats for 4 weeks. The results showed that BPOV could significantly decrease the blood glucose level and ameliorated impaired glucose tolerance in STZ-diabetic rats. BPOV has been further tested on insulin, glycogen and serum lipid studies. The results suggested BPOV has glucose-lowering activity in diabetic rats, as well as improved the disorder of lipid metabolism in diabetes. BPOV had permeability above 10(-5) cm s(-1). It was suggested good lipophilic properties. The cytotoxicity of BPOV on Caco-2 cells was measured by MTT assay which suggested BPOV have higher effect on impairment of cellular associated with lower level capacity of cellular accumulation.
Xie
Ming-jin
MJ
Department of Chemistry, Yunnan University, Cuihu North Road No.2, Kunming 650091, Yunnan, China. xmj7193@yahoo.com.cn
Li
Ling
L
Yang
Xiao-Da
XD
Liu
Wei-ping
WP
Yan
Shi-ping
SP
Niu
Yan-fen
YF
Meng
Zhao-hui
ZH
D000042:Absorption; D000818:Animals; D001682:Biological Availability; D001786:Blood Glucose / Q000378:metabolism; D018938:Caco-2 Cells; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000378:metabolism; D005951:Glucose Tolerance Test; D006003:Glycogen / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D008055:Lipids / Q000097:blood; D008297:Male; D009942:Organometallic Compounds / Q000378:metabolism* / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D010539:Permeability; D051381:Rats; D013057:Spectrum Analysis
C550827:(N,N'-bis(4-hydroxysalicylidene)-o-phenylene-diamine)oxovanadium(IV); D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D009942:Organometallic Compounds; D006003:Glycogen