title: Common genetic variation in MTNR1B is associated with serum testosterone, glucose tolerance, and insulin secretion in polycystic ovary syndrome patients.
abstract: Melatonin plays an important role in many aspects of the human reproductive process. Our results first strongly suggest that MTNR1B mediating some functions of melatonin contributes to the phenotypic expression of polycystic ovary syndrome, which provide a new insight into the role of MTNR1B gene in the pathophysiology of the disease.
authors.affiliation: Institutes of Biomedical Science, Fudan University, Shanghai, People's Republic of China. wangleiwanglei@fudan.edu.cn
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Zhang
authors.forename: Juanzi
authors.initials: J
authors.lastname: Shi
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Zhiyun
authors.initials: Z
authors.lastname: Wei
authors.forename: Aman
authors.initials: A
authors.lastname: Zhao
authors.forename: Baojie
authors.initials: B
authors.lastname: Li
authors.forename: Xinzhi
authors.initials: X
authors.lastname: Zhao
authors.forename: Qinghe
authors.initials: Q
authors.lastname: Xing
authors.forename: Lin
authors.initials: L
authors.lastname: He
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005947:Glucose / Q000378:metabolism*; D018149:Glucose Intolerance / Q000150:complications / Q000235:genetics; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D044123:Receptor, Melatonin, MT2 / Q000235:genetics*; D013739:Testosterone / Q000097:blood*
chemical_list: D007328:Insulin; D044123:Receptor, Melatonin, MT2; D013739:Testosterone; D005947:Glucose