title: The two pathways for effective orthogonal protection of L-ornithine, for amino acylation of 5'-O-pivaloyl nucleosides, describe the general and important role for the successful imitation, during the model substrates for the ribosomal mimic reaction.
abstract: Bz(NO(2))-Orn(Boc)-OCH(2)CN was synthesized as an amino acid component with effective and successful orthogonal protection for amino acylation of 5'-O-Pivaloyl nucleosides and preparation of substrates for model ribosome reactions. The synthesis was carried out using suitable combinations of the methods of peptide synthesis and modification of amino acids.
authors.affiliation: Laboratory of Biocatalysis, Institute of Organic Chemistry, Bulgarian Academy of Sciences, Sofia 1113, Bulgaria. stanislav_bayryamov@abv.bg
authors.forename: Stanislav G
authors.initials: SG
authors.lastname: Bayryamov
authors.forename: Nikolay G
authors.initials: NG
authors.lastname: Vassilev
authors.forename: Dimiter D
authors.initials: DD
authors.lastname: Petkov
mesh_terms: D000215:Acylation; D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D009952:Ornithine / Q000737:chemistry*; D012270:Ribosomes
chemical_list: D009952:Ornithine; D000241:Adenosine