title: A case of diaphragmatic clear cell carcinoma in a patient with a medical history of ovarian endometriosis.
abstract: We present a case of clear cell carcinoma located in the diaphragm in a patient with a medical history of ovarian endometriosis. Ultrasonography revealed the presence of a 2.5-cm nodule on the surface of the liver in a 65-year-old woman. She had undergone right salpingo-oophorectomy for treatment of an endometrial cyst of the right ovary at the age of 43 years and hysterectomy for treatment of a myoma of the uterus at the age of 51 years. We performed laparotomy and found that the tumor had originated from the diaphragm and invaded the liver. The diaphragm and liver were partially resected. Histopathological examination revealed the presence of clear cells and hobnail cells. The clear cells contained pale or eosinophilic cytoplasm and were arranged in a solid pattern. The hobnail cells lined the lumen and papillae. Immunohistochemical examination of the tumor cells showed positive staining for CK-7 and CA-125; negative staining for CK-20, TTF-1, and CA19-9; and weak positive staining for CEA. The findings were compatible with those of ovarian clear cell carcinoma. After 1 year, the patient had metastasis in the lung, and right lower lobectomy was performed.
authors.affiliation: Department of General Thoracic Surgery, Southern Tohoku General Hospital, 7-115 Yatsuyamada, Koriyama, Fukushima, 963-8563, Japan. koichifujiu@hotmail.com
authors.forename: Koichi
authors.initials: K
authors.lastname: Fujiu
authors.forename: Hideaki
authors.initials: H
authors.lastname: Miyamoto
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Nobuyasu
authors.initials: N
authors.lastname: Suzuki
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Takano
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Teranishi
authors.forename: Hideo
authors.initials: H
authors.lastname: Sakuma
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Suzuki
mesh_terms: D000368:Aged; D003964:Diaphragm / Q000473:pathology* / Q000601:surgery; D004715:Endometriosis / Q000150:complications*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000473:pathology; D008175:Lung Neoplasms / Q000556:secondary / Q000601:surgery; D019042:Muscle Neoplasms / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D009361:Neoplasm Invasiveness; D011013:Pneumonectomy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome