Self-assembled filamentous nanostructures for drug/gene delivery applications.
BACKGROUND
Among many nanostructural shapes, filamentous shapes can have unique advantages over the others, including longer persistence in the bloodstream. With the advent of nanotechnology in recent years, a variety of shape-controlled nanostructures has been fabricated. As a wide variety of building blocks can self-assemble into filamentous nanostructures, there are many options available for biomaterial developments with filamentous nanostructures. Similarly to conventional spherical micelles, most filamentous nanostructures have hydrophobic cores where hydrophobic guest molecules can be encapsulated, which enable them to be used in drug delivery applications. Moreover, on suitable molecular design and self-assembly process control, filamentous nanostructures can also be made to deliver nucleic acids or even both drugs and nucleic acids simultaneously.


METHODS
This review describes the self-assembly process, current developments, and prospects of filamentous nanostructures in drug and gene delivery applications.


RESULTS
This review should be helpful in gaining insight into the self-assembly process and nanostructural shape control, the advantages of constructing filamentous nanostructures, and the design of more advanced nanobiomaterials.


CONCLUSIONS
At present, the development of multifunctional nanostructures is one of the main focuses in nanobiomaterial developments. In this regard, filamentous nanostructures can be good initial targets for tailor-made nanostructure developments because they have more structural variables, as compared with spherical micelles.
Lee
Jun-hyung
JH
Yonsei University, Translational Research Center for Protein Function Control, Department of Materials Science and Engineering, Seoul, Korea.
Choi
Young Joo
YJ
Lim
Yong-beom
YB
D016503:Drug Delivery Systems; D018014:Gene Transfer Techniques; D049329:Nanostructures