Convergent ethical issues in HIV/AIDS, tuberculosis and malaria vaccine trials in Africa: Report from the WHO/UNAIDS African AIDS Vaccine Programme's Ethics, Law and Human Rights Collaborating Centre consultation, 10-11 February 2009, Durban, South Africa.
BACKGROUND
Africa continues to bear a disproportionate share of the global HIV/AIDS, tuberculosis (TB) and malaria burden. The development and distribution of safe, effective and affordable vaccines is critical to reduce these epidemics. However, conducting HIV/AIDS, TB, and/or malaria vaccine trials simultaneously in developing countries, or in populations affected by all three diseases, is likely to result in numerous ethical challenges.


METHODS
In order to explore convergent ethical issues in HIV/AIDS, TB and malaria vaccine trials in Africa, the Ethics, Law and Human Rights Collaborating Centre of the WHO/UNAIDS African AIDS Vaccine Programme hosted a consultation on the Convergent Ethical Issues in HIV/AIDS, TB and Malaria Vaccine Trials in Africa in Durban, South Africa on the 10-11 February 2009.


RESULTS
Key cross cutting ethical issues were prioritized during the consultation as community engagement; ancillary care obligations; care and treatment; informed consent; and resource sharing.


CONCLUSIONS
The consultation revealed that while there have been few attempts to find convergence on ethical issues between HIV/AIDS, TB and malaria vaccine trial fields to date, there is much common ground and scope for convergence work between stakeholders in the three fields.
Mamotte
Nicole
N
African AIDS Vaccine Programme's Ethics, Law and Human Rights Collaborating Center, School of Psychology, University of KwaZulu-Natal, Pietermaritzburg, South Africa. mamotten@ukzn.ac.za
Wassenaar
Douglas
D
Koen
Jennifer
J
Essack
Zaynab
Z
D016915:AIDS Vaccines; D000293:Adolescent; D000328:Adult; D000349:Africa / Q000453:epidemiology; D000368:Aged; D026688:Bioethical Issues; D002986:Clinical Trials as Topic / Q000941:ethics*; D033061:Ethics Consultation; D032984:Ethics, Research; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D017589:Immunization Programs / Q000941:ethics / Q000331:legislation & jurisprudence / Q000592:standards / Q000639:trends; D007258:Informed Consent / Q000941:ethics*; D007391:International Cooperation; D008288:Malaria / Q000453:epidemiology / Q000517:prevention & control; D017780:Malaria Vaccines; D008297:Male; D008875:Middle Aged; D014376:Tuberculosis / Q000453:epidemiology / Q000517:prevention & control; D032581:Tuberculosis Vaccines; D055815:Young Adult
D016915:AIDS Vaccines; D017780:Malaria Vaccines; D032581:Tuberculosis Vaccines