The reproductive outcome of female patients with myotonic dystrophy type 1 (DM1) undergoing PGD is not affected by the size of the expanded CTG repeat tract.
OBJECTIVE
This study aims to analyze the relationship between trinucleotide repeat length and reproductive outcome in a large cohort of DM1 patients undergoing ICSI and PGD.


METHODS
Prospective cohort study. The effect of trinucleotide repeat length on reproductive outcome per patient was analyzed using bivariate analysis (T-test) and multivariate analysis using Kaplan-Meier and Cox regression analysis.


RESULTS
Between 1995 and 2005, 205 cycles of ICSI and PGD were carried out for DM1 in 78 couples. The number of trinucleotide repeats does not have an influence on reproductive outcome when adjusted for age, BMI, basal FSH values, parity, infertility status and male or female affected. Cox regression analysis indicates that cumulative live birth rate is not influenced by the number of trinucleotide repeats. The only factor with a significant effect is age (p < 0.05).


CONCLUSIONS
There is no evidence of an effect of trinucleotide repeat length on reproductive outcome in patients undergoing ICSI and PGD.
Verpoest
Willem
W
Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, 101 Laarbeeklaan, 1090, Brussels, Belgium. willem.verpoest@uzbrussel.be
Seneca
Sara
S
De Rademaeker
Marjan
M
Sermon
Karen
K
De Rycke
Martine
M
De Vos
Michel
M
Haentjens
Patrick
P
Devroey
Paul
P
Liebaers
Ingeborg
I
D005260:Female; D006801:Humans; D008297:Male; D009223:Myotonic Dystrophy / Q000235:genetics*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000235:genetics*; D019836:Preimplantation Diagnosis; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic; D019680:Trinucleotide Repeat Expansion; D018911:Trinucleotide Repeats