title: Successful mobilization with AMD3100 and filgrastim with engraftment of autologous peripheral blood stem cells in a heavily pretreated pediatric patient with recurrent Burkitt lymphoma.
abstract: The authors report a case of a 13-year-old female with recurrent Burkitt lymphoma who was heavily pretreated with chemotherapy. During chemotherapy for relapse, she developed serious aspergillus infection of the palate and sinuses. Despite 10 microg/kg of filgrastim for 5 days, peripheral blood CD34(+) cells remained <or=1/microL. Hematopoietic progenitor cells were subsequently successfully mobilized with a combination of AMD3100 and filgrastim without tumor or fungus contamination. After transplantation, the patient achieved complete engraftment without exacerbation of fungal infection. This is the first case report of a pediatric patient with relapsed Burkitt lymphoma with mobilization of hematopoietic progenitor cells by AMD3100 without any adverse reactions.
authors.affiliation: The Children's Mercy Hospital, Department of Hematology/Oncology, 2401 Gillham Rd, Kansas City, MO 64108, USA. tgflatt@cmh.edu
authors.forename: Terrie
authors.initials: T
authors.lastname: Flatt
authors.forename: Karen
authors.initials: K
authors.lastname: Lewing
authors.forename: Celia
authors.initials: C
authors.lastname: Gonzalez
authors.forename: Karen
authors.initials: K
authors.lastname: Anthony
authors.forename: Robin
authors.initials: R
authors.lastname: Ryan
authors.forename: Ron
authors.initials: R
authors.lastname: Jones
authors.forename: Alan
authors.initials: A
authors.lastname: Gamis
authors.forename: Jignesh
authors.initials: J
authors.lastname: Dalal
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001596:Benzylamines; D002051:Burkitt Lymphoma / Q000175:diagnosis / Q000473:pathology / Q000628:therapy*; D000080027:Cyclams; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D019650:Hematopoietic Stem Cell Mobilization; D006571:Heterocyclic Compounds / Q000627:therapeutic use*; D006801:Humans; D036102:Peripheral Blood Stem Cell Transplantation; D011994:Recombinant Proteins; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D001596:Benzylamines; D000080027:Cyclams; D006571:Heterocyclic Compounds; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim; C088327:plerixafor