title: Comparative efficacy of peste des petits ruminants (PPR) vaccines.
abstract: Peste des petits ruminants (PPR) is a highly contagious, economically important viral disease of sheep and goats with high morbidity and mortality rates. In order to control the disease effectively, highly sensitive diagnostic tests coupled with potent vaccines are important pre-requisites. At present, there are three live attenuated PPR vaccines available in India including Sungri 96, Arasur 87 and Coimbatore 97. Indian Veterinary Research Institute (IVRI) Mukteswar developed the PPR Sungri 96 (isolate of goat origin) vaccine; while Tamil Nadu Veterinary and Animal Sciences University (TANUVAS) developed the Arasur 87 (isolate of sheep origin) and Coimbatore 97 (isolate of goat origin). In this study, the potency of these vaccines including a fourth vaccine from Institute of Animal Health and Veterinary Biologicals, Bangalore (IAH&VB) were tested as per the office International des Epizooties (OIE) guidelines by challenge studies in sheep and goats and their efficacies were evaluated using PPR C-ELISA. Potency tests of these vaccines in sheep and goats revealed that three of the vaccines were potent; however, the IAH &VB vaccine was comparatively less potent. The three vaccines could presumably be used for mass vaccination of both sheep and goats while contemplating PPR control program.
authors.affiliation: National Morbillivirus Referral Laboratory, Division of Virology, Indian Veterinary Research Institute, Mukteswar Campus, Distt. Nainital, Uttarakhand 263138, India.
authors.forename: P
authors.initials: P
authors.lastname: Saravanan
authors.forename: A
authors.initials: A
authors.lastname: Sen
authors.forename: V
authors.initials: V
authors.lastname: Balamurugan
authors.forename: K K
authors.initials: KK
authors.lastname: Rajak
authors.forename: V
authors.initials: V
authors.lastname: Bhanuprakash
authors.forename: K S
authors.initials: KS
authors.lastname: Palaniswami
authors.forename: K
authors.initials: K
authors.lastname: Nachimuthu
authors.forename: A
authors.initials: A
authors.lastname: Thangavelu
authors.forename: G
authors.initials: G
authors.lastname: Dhinakarraj
authors.forename: Raveendra
authors.initials: R
authors.lastname: Hegde
authors.forename: R K
authors.initials: RK
authors.lastname: Singh
mesh_terms: D000818:Animals; D015511:Goat Diseases / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D006041:Goats; D029021:Peste-des-Petits-Ruminants / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D018107:Peste-des-petits-ruminants virus / Q000276:immunology*; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D016896:Treatment Outcome; D014611:Vaccination / Q000379:methods / Q000592:standards; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology* / Q000592:standards
chemical_list: D014765:Viral Vaccines