CalDAG-GEFI and platelet activation.
Rapid activation of platelets at sites of vascular injury is a critical event in thrombosis and hemostasis. Here, we review recent findings, which (a) identified CalDAG-GEFI (RasGRP2) at the nexus of the rapid Ca(2+)-dependent platelet activation, (b) demonstrated a complex synergy between signaling provided by CalDAG-GEFI, protein kinase C and the Gi-coupled receptor for ADP, P2Y12, and (c) suggested CalDAG-GEFI as a novel target for anti-platelet therapy.
Stefanini
Lucia
L
Department of Medicine and Cardeza Foundation, Thomas Jefferson University, Philadelphia, PA, USA.
Bergmeier
Wolfgang
W
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics / Q000378:metabolism*; D015539:Platelet Activation; D015398:Signal Transduction / Q000502:physiology
D020662:Guanine Nucleotide Exchange Factors; C485927:Rasgrp2 protein, mouse