Synthesis and in-vitro cytotoxic evaluation of novel pyridazin-4-one derivatives.
A new series of N-aryl-4-oxo-1,4-dihydro-pyridazine-3-carboxylic acids has been synthesized by condensation of aryldiazonium with 4-hydroxy-6-methyl-2-pyrone. Some of these compounds exhibited in-vitro cytotoxic activity with moderate to excellent growth inhibition against the murine P815 mastocytoma cell line. Compound 5b showed an important cytotoxic activity against cell line P815 (IC(50 )= 0.40 microg/mL).
Mojahidi
Souad
S
Laboratory of Organic and Analytical Chemistry, Faculty of Sciences and Technology, Béni-Mellal, Morocco.
Rakib
El Mostapha
el M
Sekkak
Hanan
H
Abouricha
Said
S
Benchat
Nouredine
N
Mousse
Hassan Ait
HA
Zyad
Abdelmajid
A
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D051379:Mice; D015394:Molecular Structure; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D011724:Pyridazines