HLA polymorphism in three indigenous populations of Sabah and Sarawak.
One hundred and fifty-eight Kadazan, Iban and Bidayuh individuals registered with the Malaysian Marrow Donor Registry were typed for human leukocyte antigen (HLA)-A, HLA-B and HLA-DR. Six, seven and eight HLA-A alleles as well as 13, 15 and 16 HLA-B alleles were detected in the Kadazan, Bidayuh and Iban, respectively. The most common HLA-A allele in all three groups was HLA-A*24 with a frequency of 0.456, 0.490 and 0.422 in the Kadazan, Bidayuh and Iban, respectively. The most common HLA-B allele detected in the Kadazan was HLA-B*40 with a frequency of 0.333; for the Bidayuh and the Iban it was HLA-B*15 with a frequency of 0.460 and 0.275, respectively. The HLA-DR allele with the highest frequency in the Kadazan was HLA-DR*1502 with a frequency of 0.500. In the Iban and the Bidayuh, HLA-DRB1*1202 was the most common DR allele with frequencies of 0.235 and 0.310, respectively. The two most common haplotypes for the Kadazan are A*34-B*38-DR*1502 and A*24-B*40-DR*0405, whereas for the Bidayuh they are A*24-B*15-DR*1602 and A*24-B*35-DR*1202 and for the Iban they are A*34-*B15-DR*1502 and A*24-B*15-DR*1202.
Dhaliwal
J S
JS
Allergy and Immunology Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia. jasbir@imr.gov.my
Shahnaz
M
M
Azrena
A
A
Irda
Y A
YA
Salawati
M
M
Too
C L
CL
Lee
Y Y
YY
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens; D059947:HLA-B40 Antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008296:Malaysia; D011110:Polymorphism, Genetic; D044382:Population Groups / Q000235:genetics*
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059947:HLA-B40 Antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553514:HLA-DRB1*12:02 antigen; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II