title: Primary prostatic leiomyosarcoma with pulmonary metastases in a dog.
abstract: A 6-year-old, intact male Jack Russell terrier was diagnosed with a mass in the caudal abdomen, and ultrasound revealed a large prostatic mass. A total-body computed tomography scan was performed for staging, and lung nodules were detected. Histological examination showed a proliferation of spindle cells arranged in interlacing fascicles. Immunohistochemical staining revealed cells were cytokeratin negative and immunoreactive for vimentin and alpha-smooth muscle actin; cells stained with desmin and S-100 were negative. A diagnosis of primary prostatic leiomyosarcoma with pulmonary metastases was made. This is one of the rare cases of primary prostatic mesenchymal tumor in the canine species.
authors.affiliation: DVL Veterinary Diagnostic Laboratory, via Gramsci 1/3, Sasso Marconi, 40037 Bologna, Italy.
authors.forename: Barbara
authors.initials: B
authors.lastname: Bacci
authors.forename: Massimo
authors.initials: M
authors.lastname: Vignoli
authors.forename: Federica
authors.initials: F
authors.lastname: Rossi
authors.forename: Francesco
authors.initials: F
authors.lastname: Gallorini
authors.forename: Rossella
authors.initials: R
authors.lastname: Terragni
authors.forename: Ester L
authors.initials: EL
authors.lastname: Laddaga
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Sarli
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D007150:Immunohistochemistry / Q000662:veterinary; D007890:Leiomyosarcoma / Q000473:pathology / Q000662:veterinary*; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary*; D008297:Male; D009367:Neoplasm Staging / Q000662:veterinary; D011471:Prostatic Neoplasms / Q000473:pathology / Q000662:veterinary*