title: Anti-CENP-B antibodies are associated with prolonged survival in breast cancer.
abstract: OBJECTIVE
  Presence of a relationship between autoimmunity and malignant diseases has been investigated for a long time. Anti-SS-B and anti-centromere protein (CENP)-B antibodies are used as serologic markers for autoimmune diseases. In this study, these autoantibodies were studied in breast cancer patients, and their effect on survival was evaluated.
  
  
  METHODS
  Breast cancer patients treated between January and June 2003 were prospectively included in this study. Antibodies were studied by ELISA, and serum values of greater than 10 U/ml were accepted as positive.
  
  
  RESULTS
  In total, 55 patients with breast cancer were prospectively included in the study. Median follow-up time was 62 months. In univariate analysis, estrogen receptor status, anti-CENP-B antibody status and tumor size significantly affected disease-free survival, whereas overall survival was significantly dependent on tumor size and anti-CENP-B antibody status. In multivariate analysis, anti-CENP-B status was the independent prognostic factor for disease-free survival, whereas tumor size and anti-CENP-B status were independent prognostic factors for overall survival.
  
  
  CONCLUSIONS
  Anti-CENP-B autoantibodies in breast cancer patients prolong disease-free and overall survival.
authors.affiliation: Department of General Surgery, Ankara Oncology Hospital, Turkey. atalay_can@hotmail.com
authors.forename: Can
authors.initials: C
authors.lastname: Atalay
authors.forename: Lutfi
authors.initials: L
authors.lastname: Dogan
authors.forename: Gonca
authors.initials: G
authors.lastname: Atalay
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D014408:Biomarkers, Tumor / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology* / Q000401:mortality / Q000473:pathology; D051936:Centromere Protein B / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D009367:Neoplasm Staging
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D014408:Biomarkers, Tumor; C497926:CENPB protein, human; D051936:Centromere Protein B