title: Ghrelin and adiponectin levels in colostrum, cord blood and maternal serum.
abstract: BACKGROUND
  Ghrelin and adiponectin, which are considered to take part in the regulation of energy metabolism, have been found in breast milk and cord blood. The aims of this study were to determine ghrelin and adiponectin levels in colostrum, cord blood and maternal serum and to investigate the correlations between colostrum and cord blood levels of these peptides and the anthropometry of newborn infants and their mothers.
  
  
  METHODS
  Total ghrelin (TGHR), free ghrelin (FGHR) and adiponectin levels were studied in colostrum and the serum samples of 25 healthy lactating women and the cord blood of their healthy full-term infants.
  
  
  RESULTS
  No significant differences could be found among TGHR and adiponectin levels in colostrum, cord blood and maternal serum. The median FGHR level in colostrum was significantly higher than that of maternal serum and cord blood. The colostrum TGHR was negatively correlated with body mass index (BMI) and weight of the infants at birth. TGHR and FGHR levels in colostrum were found to be positively correlated with those of maternal TGHR and FGHR concentrations, respectively. Adiponectin levels in colostrum were not correlated with BMI or birthweight of the infants or BMI of the mothers.
  
  
  CONCLUSIONS
  These findings suggest that the source of ghrelin in breast milk is probably both breast tissue itself and the serum of the mother. Ghrelin in colostrum seems to be related to the anthropometry of infants even at birth, unlike adiponectin.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey.
authors.forename: Nihal O
authors.initials: NO
authors.lastname: Dündar
authors.forename: Bumin
authors.initials: B
authors.lastname: Dündar
authors.forename: Gökhan
authors.initials: G
authors.lastname: Cesur
authors.forename: Nigar
authors.initials: N
authors.lastname: Yilmaz
authors.forename: Recep
authors.initials: R
authors.lastname: Sütçu
authors.forename: Fehmi
authors.initials: F
authors.lastname: Ozgüner
mesh_terms: D052242:Adiponectin / Q000032:analysis* / Q000097:blood; D000328:Adult; D003126:Colostrum / Q000737:chemistry*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D054439:Ghrelin / Q000032:analysis* / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D008895:Milk, Human / Q000737:chemistry; D011247:Pregnancy
chemical_list: D052242:Adiponectin; D054439:Ghrelin