An unusual association: anti-Jo1 and anti-SRP antibodies in the serum of a patient with polymyositis.
The idiopathic inflammatory myopathies are systemic autoimmune diseases characterized by chronic inflammation, resulting in the progressive weakness of the proximal muscles. Myositis-specific or myositis-associated autoantibodies can often be found in serum of polymyositis and dermatomyositis patients. This autoantibody presence may play a significant role in patient diagnosis and classification. We present a female polymyositis patient characterized with serious muscle weakness and lung involvement. Anti-Jo1 antibodies were detected in the patient's serum at the time of diagnosis. After 5 years of treatment and surveillance, recent laboratory analysis showed the presence anti-SRP antibody in her serum.
Vincze
Melinda
M
Division of Immunology, 3rd Department of Internal Medicine, Institute for Internal Medicine, University of Debrecen Medical and Health Science Center, Moricz Zs. krt. 22, 4032, Debrecen, Hungary.
Molnár
Peter A
PA
Tumpek
Judit
J
Szollosi
Lászlóné
L
Gyetvai
Agnes
A
Kapitány
Anikó
A
Dankó
Katalin
K
D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D017285:Polymyositis / Q000097:blood / Q000175:diagnosis / Q000276:immunology; D012346:RNA, Transfer, Amino Acyl; D018271:Signal Recognition Particle / Q000276:immunology
D001323:Autoantibodies; D012346:RNA, Transfer, Amino Acyl; D018271:Signal Recognition Particle