The ApoB/ApoA1 ratio is associated with metabolic syndrome and its components in a Chinese population.
In this study, we assessed whether the apolipoprotein B/apolipoprotein A1 ratio (ApoB/ApoA1) is related to metabolic syndrome (MS) and its components in an urban Chinese population. A total of 709 community residents were enrolled. Metabolic syndrome was defined according to the International Diabetes Federation definition in 2005. The high ApoB/ApoA1 group was defined as the gender-specific upper quartile of the ApoB/ApoA1 ratio. Insulin resistance (IR) was defined as the upper quartile of Homa-IR. The ApoB/ApoA1 ratio was significantly higher in subjects with MS, compared to those without (p < 0.05). After adjusting for age and gender, subjects with MS (odds ratio [OR] = 3.5) or IR (OR = 2.3) were more likely to be in the high ApoB/ApoA1 group. The ApoB/ApoA1 ratio increased significantly as the number of MS components increased (p < 0.05). Taken together, these data demonstrate that the ApoB/ApoA1 ratio is strongly associated with MS and its components in an urban Chinese population.
Zhong
Li
L
Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, No.1 Youyi Street, Chongqing, China.
Li
Qifu
Q
Jiang
Yuanjuan
Y
Cheng
Dan
D
Liu
Zhoujun
Z
Wang
Bangqiong
B
Luo
Rong
R
Cheng
Qingfeng
Q
Qing
Hua
H
D000328:Adult; D016632:Apolipoprotein A-I / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D002681:China; D003920:Diabetes Mellitus / Q000175:diagnosis; D050171:Dyslipidemias / Q000097:blood; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000209:etiology; D008875:Middle Aged; D009765:Obesity / Q000097:blood; D016017:Odds Ratio; D012307:Risk Factors
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D015415:Biomarkers