D3 receptor target engagement in humans with ABT-925 using [11C](+)-PHNO PET.
Day
Mark
M
Global Pharmaceutical Research and Development, Translational Neuroimaging, Abbott, Abbott Park, IL60064, USA. mark.day@abbott.com
Bain
Earle
E
Marek
Gerard
G
Saltarelli
Mario
M
Fox
Gerard B
GB
D001921:Brain / Q000000981:diagnostic imaging* / Q000187:drug effects; D006801:Humans; D010078:Oxazines / Q000493:pharmacokinetics*; D049268:Positron-Emission Tomography / Q000379:methods*; D050637:Receptors, Dopamine D3 / Q000037:antagonists & inhibitors* / Q000378:metabolism*
D010078:Oxazines; D050637:Receptors, Dopamine D3; C042631:naxagolide