Synthesis and fluorescence of the new environment-sensitive fluorophore 6-chloro-2,3-naphthalimide derivative.
Convenient and efficient synthesis of a new environmentally sensitive chlorine-substituted 2,3-naphthalimide-based fluorophore is reported. Benzotriazole carboxyl group activation of the 6-chloro-fluorophore enabled quick labeling of free and Fmoc-protected amino acids. The photophysical properties of the compounds obtained include high quantum yields in solvents of different polarity: water, methanol, acetonitrile and hexane.
Katritzky
Alan R
AR
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. katritzky@chem.ufl.edu
Ozcan
Sevil
S
Todadze
Ekaterina
E
D000042:Absorption; D000596:Amino Acids / Q000378:metabolism; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D053644:Naphthalimides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D055668:Photochemical Processes; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013194:Staining and Labeling
C549828:2-(6-chloro-1,3-dioxo-1H-benzo(f)isoindol-2(3H)-yl)acetic acid; D000596:Amino Acids; D005456:Fluorescent Dyes; D053644:Naphthalimides