Clinical significance of tumor necrosis factor receptor superfamily member 11b polymorphism in prostate cancer.
BACKGROUND
Bone metastases are the most critical complication of prostate cancer (PCa), resulting in severe morbidity and mortality. Tumor necrosis factor receptor superfamily member 11b (TNFRSF11B) is a critical regulator between PCa cells and the bone environment. Recently, TNFRSF11B rs10505346 has been implicated in PCa risk in the Cancer Genetic Markers of Susceptibility genomewide association study. However, the association between this variant and biochemical failure in PCa patients receiving radical prostatectomy (RP) has not been determined.


METHODS
Associations of TNFRSF11B rs10505346 with age at diagnosis, preoperative prostate-specific antigen (PSA) level, Gleason score, pathologic stage, surgical margin, and PSA recurrence were evaluated in a cohort of 314 localized PCa patients receiving RP. The prognostic significance on PSA recurrence was assessed by Kaplan-Meier analysis and Cox regression model.


RESULTS
The mean level of preoperative PSA and the relative risks of PSA recurrence after RP were lower in individuals with T allele than in those with the G allele at TNFRSF11B rs10505346 (P = 0.019 and 0.014, respectively). The T allele of rs10505346 remained a protective factor against PSA recurrence (P = 0.022) in multivariate Cox regression model after considering all clinicopathological risk factors except PSA level.


CONCLUSIONS
Our data suggest that TNFRSF11B rs10505346 is associated with PSA level and might be a prognostic factor for the recurrence of PSA in PCa patients receiving RP.
Bao
Bo-Ying
BY
Department of Pharmacy, China Medical University, Taichung, Taiwan.
Lin
Victor C
VC
Huang
Shu-Hung
SH
Pao
Jiunn-Bey
JB
Chang
Ta-Yuan
TY
Lu
Te-Ling
TL
Lan
Yu-Hsuan
YH
Chen
Lu-Min
LM
Ting
Wen-Chien
WC
Yang
Wen-Hui
WH
Hsieh
Chi-Jeng
CJ
Huang
Shu-Pin
SP
D000368:Aged; D000483:Alleles; D014408:Biomarkers, Tumor / Q000235:genetics*; D015331:Cohort Studies; D018450:Disease Progression; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D009367:Neoplasm Staging; D053244:Osteoprotegerin / Q000235:genetics*; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D016016:Proportional Hazards Models; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery*
D014408:Biomarkers, Tumor; D053244:Osteoprotegerin