title: Melanotic oncocytic metaplasia of the nasopharynx as a benign mimicker of malignant melanoma: a case report.
abstract: BACKGROUND
  Melanotic variant of oncocytic metaplasia of the nasopharynx is an extremely rare condition.
  
  
  METHODS
  A 73-year-old Japanese man presented with nasal congestion and chill. Nasoscopic examination revealed multiple black nodules around the bilateral torus tubarius. The nodules were biopsied to determine the histology. The clinical differential diagnosis was malignant melanoma or hemangioma. Microscopically, there were oncocytic plump cells with abundant brown pigmented granules showing glandular pattern. No significant atypia was found. The pigment was positive for Fontana-Masson staining, and negative for Berlin blue staining, showing that it was melanin pigment. Immunohistochemically, S100-positive HMB45-negative dendritic cells were also found.
  
  
  CONCLUSIONS
  Such a pigmented variant of benign oncocytic lesion is very rare, and only 15 cases have been reported in the English literature. As a benign mimicker of malignant melanoma, melanocytic oncocytic metaplasia should be always taken into consideration in the clinical setting.
authors.affiliation: Division of Pathology, Kobe University Graduate School of Medicine, Kobe, Japan. kondo@med.kobe-u.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kondo
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Mori
authors.forename: Shiori
authors.initials: S
authors.lastname: Oka
authors.forename: Setsuko
authors.initials: S
authors.lastname: Morinaka
mesh_terms: D000368:Aged; D001706:Biopsy; D003937:Diagnosis, Differential; D004724:Endoscopy; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008543:Melanins / Q000032:analysis*; D008545:Melanoma / Q000175:diagnosis*; D008679:Metaplasia; D009302:Nasopharyngeal Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis*; D009305:Nasopharynx / Q000737:chemistry / Q000473:pathology*; D011237:Predictive Value of Tests; D013194:Staining and Labeling
chemical_list: D008543:Melanins