Bradycardia and hypotension in mianserin intoxication.
Cardiotoxicity is an important adverse effect of tricyclic antidepressants. But cardiac side effects after intoxication with the tetracyclic mianserin are rare. In this paper, we describe a case in which bradycardia and hypotension occured due to mianserin overdose. A 37-year-old woman was admitted to the medical intensive care unit for self-poisoning with 30 tablets of 10 mg mianserin 2 hours before her admission. The patient denied taking any other drugs. Four hours after her admission, bradycardia and hypotension occurred and she began to suffer from giddiness. Atropine and theophylline were given. On the second and third day, her heart rate and blood pressure were normal. Based on this case, we estimate the probability of bradycardia and hypotension in mianserin intoxication and the significance of closely monitoring the patient.
Koseoglu
Zikret
Z
Kara
Banu
B
Satar
Salim
S
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D018687:Antidepressive Agents, Second-Generation / Q000506:poisoning*; D001285:Atropine / Q000627:therapeutic use; D001919:Bradycardia / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D008803:Mianserin / Q000506:poisoning*; D020258:Neurotoxicity Syndromes / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D013406:Suicide, Attempted; D013806:Theophylline / Q000627:therapeutic use; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use
D000889:Anti-Arrhythmia Agents; D018687:Antidepressive Agents, Second-Generation; D014665:Vasodilator Agents; D008803:Mianserin; D001285:Atropine; D013806:Theophylline