title: Molecular interactions between Bos taurus interferon-tau1c and human type I interferon receptor.
abstract: Interferon (IFN)-tau secreted only by ruminant endometrium, helps in maternal recognition of pregnancy and exhibit antiviral and antiproliferative activity. Among different types of IFN-tau, IFN-tau1c and IFN- tau3a are the most highly expressed isoforms. In the present study structure of INF-tau1c was predicted using homology modelling. The best model was selected based on overall stereo-chemical quality. The generated 3D structure of the Interferon-tau1c protein of Bos taurus was predicted using the ovine interferon-tau (PDB ID: 1B5L_A) as template. The structure comprises of 5 alpha helices separated by loop regions, which is similar to the one predicted for other IFNs. Molecular interactions of bovine IFN-tau1c with human interferon Type 1 receptor (IFNAR1) was explored in an attempt to predict human IFNAR1 binding sites of IFN-tau1c.
authors.affiliation: Embryo Biotechnology Lab, Animal Biotechnology Centre, National Dairy Research Institute, Karnal-132001, Haryana, India.
authors.forename: Vishawdeep Singh
authors.initials: VS
authors.lastname: Jamwal
authors.forename: Gourav
authors.initials: G
authors.lastname: Modi
authors.forename: Aman
authors.initials: A
authors.lastname: George
authors.forename: Manmohan Singh
authors.initials: MS
authors.lastname: Chauhan