Disulfiram: an old therapeutic with new applications.
Disulfiram treatment, despite its limitations, remains a viable option as a treatment for alcohol dependence and has shown recent promise in treating (1) those with co-morbid alcohol dependence and post-traumatic stress disorder, (2) those with co-morbid cocaine- and alcohol-dependence, and (3) those with cocaine-dependence alone. Although disulfiram's mechanism of action in alcohol dependence was long thought to be its effects as a psychological deterrent, more recent studies have uncovered potential anti-craving effects as well as direct effects of disulfiram on cocaine abuse, highlighting a few of the many potential and unique benefits disulfiram may have through its inhibition of dopamine beta-hydroxylase. This article will review the major clinical trials of disulfiram spanning nearly 60 years. We will discuss the pharmacodynamics and pharmacokinetics of disulfiram, indications and limitations of its use, suggestions for appropriate patient populations, and monitoring for compliance and adverse effects. We will also review recent literature on newer potential applications for disulfiram use via its unique action on dopamine beta-hydroxylase.
Barth
Kelly S
KS
Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC 29425, USA. stephen@musc.edu
Malcolm
Robert J
RJ
D000427:Alcohol Deterrents / Q000494:pharmacology / Q000627:therapeutic use; D020268:Alcohol-Induced Disorders, Nervous System / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D000437:Alcoholism / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology; D004221:Disulfiram / Q000494:pharmacology* / Q000627:therapeutic use*; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy / Q000201:enzymology / Q000503:physiopathology
D000427:Alcohol Deterrents; D004791:Enzyme Inhibitors; D004299:Dopamine beta-Hydroxylase; D004221:Disulfiram