Recent progress in research on ribosome inactivating proteins.
The intent of this article is to review recent literature on ribosome inactivating proteins (RIPs) including isolation and characterization of new RIPs, studies on the crystal structures and mechanisms of actions of RIPs, the use of saporin-based neurotoxins to selectively lesion cholinergic neurons in neuroscience research, and the use of RIP-based conjugates and immunotoxins in anticancer therapy.
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The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China.
Wong
Jack Ho
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Wang
Hexiang
H
D000818:Animals; D006801:Humans; D000922:Immunotoxins / Q000737:chemistry / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects; D011487:Protein Conformation; D054788:Ribosome Inactivating Proteins / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D054789:Ribosome Inactivating Proteins, Type 1 / Q000737:chemistry / Q000494:pharmacology; D000076985:Saporins; D013329:Structure-Activity Relationship
D000922:Immunotoxins; D054789:Ribosome Inactivating Proteins, Type 1; D054788:Ribosome Inactivating Proteins; D000076985:Saporins