Monoclonal antibodies used as prophylactic, therapeutic and diagnostic agents.
Monoclonal antibodies can be of mouse, part mouse part human (chimeric, humanized), or of human origin. Their preparation involves hybridoma, gene cloning, gene recombination, phage display, and gene transfection techniques. The preparation, mechanism of action, uses, and possible adverse effects of most of the available monoclonal antibodies used as prophylactic, therapeutic, and diagnostic agents are reviewed.
Chakhtoura
Marita
M
Department of Microbiology and Immunology, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Abdelnoor
Alexander M
AM
D000818:Animals; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000096:biosynthesis / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D000922:Immunotoxins / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use
D000911:Antibodies, Monoclonal; D000922:Immunotoxins