Identification of Wnt family inhibitors: a pituitary tumor directed whole genome approach.
Wnt signaling pathways are important regulators of normal embryological development including that of the pituitary gland. Altered Wnt pathway expression is common in many human tumors however until recently the role of these pathways in human pituitary tumorigenesis has received little attention. The advent of microarray analysis has identified several Wnt pathway inhibitors that are frequently perturbed in pituitary tumors. In this review we summarize the role of these inhibitors in other human tumor types and review the current state of knowledge of Wnt inhibitor expression in pituitary tumors.
Elston
Marianne S
MS
Department of Endocrinology, Waikato Hospital, Private Bag 3200, Hamilton 3240, Waikato, New Zealand. elstonm@clear.net.nz
Clifton-Bligh
Roderick J
RJ
D015972:Gene Expression Regulation, Neoplastic; D016678:Genome; D006801:Humans; D010902:Pituitary Gland / Q000378:metabolism / Q000473:pathology; D010911:Pituitary Neoplasms / Q000235:genetics* / Q000473:pathology; D015398:Signal Transduction / Q000235:genetics; D051153:Wnt Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051176:beta Catenin / Q000378:metabolism
D051153:Wnt Proteins; D051176:beta Catenin