title: Disseminated Scedosporium/Pseudallescheria infection after double-lung transplantation in patients with cystic fibrosis.
abstract: We report a case of disseminated Scedosporium/Pseudallescheria infection due to Pseudallescheria boydii sensu stricto after lung transplantation in a patient with cystic fibrosis. Dissemination occurred under voriconazole. Despite surgery and combination therapy with voriconazole, caspofungin, and terbinafine, the patient died 8 months after transplantation. Previously reported cases are reviewed.
authors.affiliation: Laboratoire de Parasitologie-Mycologie, CHU de Nantes, Hôtel Dieu, 9 Quai Moncousu, 44093 Nantes Cedex 1, France. florent.morio@chu-nantes.fr
authors.forename: Florent
authors.initials: F
authors.lastname: Morio
authors.forename: Delphine
authors.initials: D
authors.lastname: Horeau-Langlard
authors.forename: Françoise
authors.initials: F
authors.lastname: Gay-Andrieu
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Talarmin
authors.forename: Alain
authors.initials: A
authors.lastname: Haloun
authors.forename: Michelle
authors.initials: M
authors.lastname: Treilhaud
authors.forename: Philippe
authors.initials: P
authors.lastname: Despins
authors.forename: Frédérique
authors.initials: F
authors.lastname: Jossic
authors.forename: Laurence
authors.initials: L
authors.lastname: Nourry
authors.forename: Isabelle
authors.initials: I
authors.lastname: Danner-Boucher
authors.forename: Sabine
authors.initials: S
authors.lastname: Pattier
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Bouchara
authors.forename: Patrice
authors.initials: P
authors.lastname: Le Pape
authors.forename: Michel
authors.initials: M
authors.lastname: Miegeville
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging; D000077336:Caspofungin; D018890:Chemoprevention / Q000379:methods; D003550:Cystic Fibrosis / Q000628:therapy*; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D054714:Echinocandins / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D055666:Lipopeptides; D008172:Lung Diseases, Fungal / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D016040:Lung Transplantation / Q000009:adverse effects*; D008279:Magnetic Resonance Imaging; D008826:Microbial Sensitivity Tests; D008853:Microscopy; D008969:Molecular Sequence Data; D009281:Naphthalenes / Q000627:therapeutic use; D011541:Pseudallescheria / Q000145:classification / Q000166:cytology / Q000235:genetics / Q000302:isolation & purification*; D011743:Pyrimidines / Q000627:therapeutic use; D012331:RNA, Fungal / Q000235:genetics; D012339:RNA, Ribosomal, 28S / Q000235:genetics; D011859:Radiography; D021681:Scedosporium / Q000145:classification / Q000166:cytology / Q000235:genetics / Q000302:isolation & purification*; D017422:Sequence Analysis, DNA; D000077291:Terbinafine; D014230:Triazoles / Q000627:therapeutic use; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D004271:DNA, Fungal; D054714:Echinocandins; D055666:Lipopeptides; D009281:Naphthalenes; D011743:Pyrimidines; D012331:RNA, Fungal; D012339:RNA, Ribosomal, 28S; D014230:Triazoles; D000077336:Caspofungin; D000077291:Terbinafine; D065819:Voriconazole