title: Prevalence of factor V leiden mutation in patients with thrombosis in Tunisia.
abstract: This study determined the prevalence of inherited factor V Leiden mutation in a group of 128 thrombosis patients (102 with venous thrombosis and 26 with arterial thrombosis) attending a hospital in Sousse, Tunisia, and a control group of 100 with no history of thrombosis. Using an allele-specific PCR amplification technique, factor V Leiden was found in significantly more patients (20.3%) than controls (6.0%). The higher prevalence was significant in the subgroup of venous thrombosis patients but not in arterial thrombosis patients. The allele frequency was 3.5% in the normal Tunisian population. Screening Tunisian patients with venous thrombosis and their relatives for factor V Leiden may be justified.
authors.affiliation: Immunogenetic Unit, Faculty of Medicine of Sousse, Sousse, Tunisia.
authors.forename: A
authors.initials: A
authors.lastname: Ajem
authors.forename: A
authors.initials: A
authors.lastname: Slama
authors.forename: F B H
authors.initials: FB
authors.lastname: Slama
authors.forename: T
authors.initials: T
authors.lastname: Mehjoub
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005165:Factor V / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D005820:Genetic Testing; D006801:Humans; D007223:Infant; D007297:Inpatients / Q000706:statistics & numerical data; D008875:Middle Aged; D010375:Pedigree; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012307:Risk Factors; D013927:Thrombosis / Q000453:epidemiology / Q000235:genetics; D014416:Tunisia / Q000453:epidemiology
chemical_list: C095381:factor V Leiden; D005165:Factor V