Genetic polymorphism of epidermal growth factor 61A>G and cancer risk: a meta-analysis.
BACKGROUND
Numerous studies have investigated the risk of cancer associated with the polymorphism of epidermal growth factor (EGF) 61A>G, but the results have been inconsistent. We performed this meta-analysis to drive a more precise estimation of association between this polymorphism and risk of cancer.


METHODS
Electronic searches of PubMed and EMBASE were conducted to select studies. Case-control studies containing available genotype frequencies of EGF 61A>G were chose, and Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association.


RESULTS
23 case-control studies including 5578 cases and 7306 controls were identified. This meta-analysis showed significant effect of EGF 61A>G on cancer risk (GG vs. AA: OR=1.34, 95%CI=1.05-1.72; GG vs. GA+AA: OR=1.23, 95%CI=1.03-1.47; GG+GA vs. AA: OR=1.18, 95%CI=1.02-1.38). In subgroup analysis, significant increased risk was found in gastric cancer and glioma in additive model (OR=1.54, 95%CI=1.13-2.12; OR=1.69, 95%CI=1.21-2.37) and in recessive model (OR=1.29, 95%CI=1.10-1.52; OR=1.54, 95%CI=1.16-2.04).


CONCLUSIONS
This meta-analysis suggested that the EGF 61G allele is a risk factor of cancer, especially for gastric cancer and glioma.
Zhang
Yan-Mei
YM
Department of Internal Medicine, the Second Hospital of Anhui Medical University, 678 Furong Road, Hefei 230601, China. zhangym19840130@126.com <zhangym19840130@126.com>
Cao
Chao
C
Liang
Kun
K
D016022:Case-Control Studies; D004815:Epidermal Growth Factor / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic
D004815:Epidermal Growth Factor