title: [Interaction of omnic (tamsulozine) and its generic analogues with alpha-adrenoreceptors].
abstract: In current practice of pharmacotherapy of prostatic adenoma alpha1-adrenoblockers are first-line drugs the efficacy and safety of which have been proved in many randomized studies. Because of the appearance of a large amount of generic analogues of tamsulozine on the market we studied the ability of tamsulozine analogues to bind with alpha-adrenoreceptors on rat and human prostate affected by adenoma. Significant differences on the receptor level of interaction were found. Omnik, compared to other generic analogues of tamsulozine, has the highest affinity to alpha1-adrenoreceptors.
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Pushkar'
authors.forename: Iu B
authors.initials: IuB
authors.lastname: belousov
authors.forename: A S
authors.initials: AS
authors.lastname: Dukhanin
authors.forename: O A
authors.initials: OA
authors.lastname: Maneshina
authors.forename: A V
authors.initials: AV
authors.lastname: Govorov
authors.forename: M A
authors.initials: MA
authors.lastname: Kurdzhiev
mesh_terms: D000236:Adenoma / Q000188:drug therapy / Q000378:metabolism* / Q000382:microbiology*; D000317:Adrenergic alpha-Antagonists / Q000493:pharmacokinetics* / Q000494:pharmacology; D000818:Animals; D016568:Drugs, Generic / Q000493:pharmacokinetics* / Q000494:pharmacology; D006801:Humans; D008297:Male; D011467:Prostate / Q000378:metabolism*; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000378:metabolism*; D013449:Sulfonamides / Q000493:pharmacokinetics* / Q000494:pharmacology; D000077409:Tamsulosin
chemical_list: D000317:Adrenergic alpha-Antagonists; D016568:Drugs, Generic; D011942:Receptors, Adrenergic, alpha; D013449:Sulfonamides; D000077409:Tamsulosin