title: Reactivation potency of the acetylcholinesterase reactivator obidoxime is limited.
abstract: BACKGROUND
  Obidoxime is the only one reactivator of acetylcholinesterase (AChE) approved in Czech Republic for the treatment of nerve agent and pesticide poisonings for civilian sector. Due to the fact that misuse of nerve agents by terrorists or by an accidental poisoning by farmers is possible, re-evaluation of its universality is needed. It is also needed by the fact that clinical findings considering this oxime are controversial.
  
  
  OBJECTIVE
  In this study, we wanted to summarize if obidoxime is a universal reactivator or if its reactivation potency in case of some organophosphorus inhibitors is limited.
  
  
  METHODS
  Using our in vitro method, rat brain AChE was inhibited by eleven organophosphorus AChE inhibitors and then reactivated by obidoxime.
  
  
  CONCLUSIONS
  It was found that obidoxime could not be termed as universal antidote. Due to this, development of new promising candidates as replacement of obidoxime is recommended.
authors.affiliation: Center of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic. kucakam@pmfhk.cz
authors.forename: Kamil
authors.initials: K
authors.lastname: Kuca
authors.forename: Kamil
authors.initials: K
authors.lastname: Musilek
authors.forename: Miroslav
authors.initials: M
authors.lastname: Pohanka
authors.forename: Vlastimil
authors.initials: V
authors.lastname: Dohnal
authors.forename: Jiri
authors.initials: J
authors.lastname: Patocka
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D000931:Antidotes / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D002619:Chemical Warfare Agents / Q000506:poisoning*; D002801:Cholinesterase Reactivators / Q000494:pharmacology*; D066298:In Vitro Techniques; D009768:Obidoxime Chloride / Q000494:pharmacology*; D010575:Pesticides / Q000506:poisoning*; D051381:Rats
chemical_list: D000931:Antidotes; D002619:Chemical Warfare Agents; D002801:Cholinesterase Reactivators; D010575:Pesticides; D009768:Obidoxime Chloride; D000110:Acetylcholinesterase