Microbial translocation correlates with the severity of both HIV-1 and HIV-2 infections.
Microbial translocation has been linked to systemic immune activation during human immunodeficiency virus (HIV) type 1 infection. Here, we show that an elevated level of microbial translocation, measured as plasma lipopolysaccharide (LPS) concentration, correlates with AIDS in both individuals infected with HIV type 1 and individuals infected with HIV type 2. LPS concentration also correlates with CD4+ T cell count and viral load independently of HIV type. Furthermore, elevated plasma LPS concentration was found to be concomitant with defective innate and mitogen responsiveness. We suggest that microbial translocation may contribute to loss of CD4+ T cells, increase in viral load, and defective immune stimuli responsiveness during both HIV type 1 and HIV type 2 infections.
Nowroozalizadeh
Salma
S
Swedish Institute for Infectious Disease Control, Solna, Sweden.
Månsson
Fredrik
F
da Silva
Zacarias
Z
Repits
Johanna
J
Dabo
Braima
B
Pereira
Carla
C
Biague
Antonio
A
Albert
Jan
J
Nielsen
Jens
J
Aaby
Peter
P
Fenyö
Eva Maria
EM
Norrgren
Hans
H
Holmgren
Birgitta
B
Jansson
Marianne
M
D018988:Bacterial Translocation / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000382:microbiology* / Q000821:virology; D015497:HIV-1 / Q000472:pathogenicity*; D015498:HIV-2 / Q000472:pathogenicity*; D006801:Humans; D008070:Lipopolysaccharides / Q000097:blood; D008297:Male; D051193:Toll-Like Receptors / Q000502:physiology; D019562:Viral Load / Q000276:immunology
D008070:Lipopolysaccharides; D051193:Toll-Like Receptors