An old dog learns new tricks: a novel function for Cdc20-APC in dendrite morphogenesis in neurons.
The E3 ubiquitin ligases Cdc20-anaphase-promoting complex (Cdc20-APC) and Cdh1-APC play key roles in cell cycle transitions in proliferating cells. Remarkably, these ubiquitin ligases are also expressed in postmitotic neurons, raising interest in non-mitotic functions of the APC. Cdh1-APC has been implicated in diverse functions in the nervous system, from the control of axon growth and patterning to synapse development to neuron survival. However, until recently the question of whether Cdc20-APC harbors functions in neurons remained unanswered. New evidence from Kim et al. (2009) has uncovered a novel role for Cdc20-APCin dendrite growth and elaboration in post-mitotic neurons. Interestingly, the histone deacetylase HDAC6 augments Cdc20-APC activity at the centrosome by promoting Cdc20 polyubiquitination. In turn, Cdc20-APC triggers the degradation of the centrosomally localized protein Id1 and thereby promotes dendrite growth and elaboration. These findings have advanced our understanding of APC biology in neuronal connectivity in the brain.
Puram
Sidharth V
SV
Department of Pathology, Harvard Medical School, Boston, MA USA.
Kim
Albert H
AH
Bonni
Azad
A
D064173:Anaphase-Promoting Complex-Cyclosome; D000818:Animals; D064199:Cdc20 Proteins; D018797:Cell Cycle Proteins / Q000378:metabolism*; D018385:Centrosome / Q000378:metabolism; D003712:Dendrites / Q000378:metabolism*; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases / Q000378:metabolism; D009024:Morphogenesis; D034622:RNA Interference; D051381:Rats; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism*
D064199:Cdc20 Proteins; C577494:Cdc20 protein, rat; D018797:Cell Cycle Proteins; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; C545556:HDAC6 protein, rat; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases