title: Osteoinvasive subungual melanoma: a case and review.
abstract: Subungual melanoma is a relatively rare variant of melanoma, accounting for 0.7-3.5% of all melanoma cases in the Caucasian population. Curiously, it occurs in 8-33% of cases in black, Asian, Native American and Hispanic populations, which generally face a substantially lower risk of melanoma. Herein the authors report the case of a 69-year-old Hispanic female with a subungual melanoma of the acral lentiginous type that directly invaded the periosteum, cortex and medulla of the distal phalanx. In addition, we review published reports of acral lentiginous melanoma with osseous invasion and discuss the evidence, on a molecular level, for this entity's aggressive pattern of invasion. The review of cases is limited to those found through the PubMed search engine.
authors.affiliation: The Mount Sinai School of Medicine, Department of Dermatology, NewYork, NY, USA. Becky.Kleinerman@gmail.com
authors.forename: Rebecca
authors.initials: R
authors.lastname: Kleinerman
authors.forename: David
authors.initials: D
authors.lastname: Kriegel
authors.forename: Imran
authors.initials: I
authors.lastname: Amir
authors.forename: Patrick O
authors.initials: PO
authors.lastname: Emanuel
authors.forename: Bryan C
authors.initials: BC
authors.lastname: Markinson
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000556:secondary*; D005260:Female; D006801:Humans; D008545:Melanoma / Q000473:pathology*; D009361:Neoplasm Invasiveness; D010521:Periosteum / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*; D050277:Toe Phalanges / Q000473:pathology*