Oxazolomycins: natural product lead structures for novel antibacterials by click fragment conjugation.
Conjugation of amide and lactam subunits by a 'Click' type approach provides access to structural mimics of the oxazolomycin series of natural products, some of which exhibit antibacterial activity.
Bagwell
Claire L
CL
Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, United Kingdom.
Moloney
Mark G
MG
Yaqoob
Muhammad
M
D000577:Amides / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D001424:Bacterial Infections / Q000188:drug therapy; D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects*; D006801:Humans; D007769:Lactams / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010080:Oxazoles / Q000737:chemistry* / Q000494:pharmacology*; D011760:Pyrrolidinones; D013141:Spiro Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects*
D000577:Amides; D000900:Anti-Bacterial Agents; D001688:Biological Products; D007769:Lactams; D010080:Oxazoles; D011760:Pyrrolidinones; D013141:Spiro Compounds; C077919:diffusomycin