The contribution of the Epstein-Barr virus to the pathogenesis of childhood lymphomas.
The Epstein-Barr virus (EBV) is a lymphotropic herpes virus with oncogenetic properties which can lead to the development of lymphomas such as Burkitt's lymphoma (BL), Hodgkin's lymphoma (HL), or post-transplant lymphoma. This review discusses our current understanding of lymphomagenesis in relation to EBV and the potential for targeted therapies.
Cader
Fathima Zumla
FZ
Cancer Research UK Institute for Cancer Studies, University of Birmingham, UK.
Kearns
Pamela
P
Young
Lawrence
L
Murray
Paul
P
Vockerodt
Martina
M
D000998:Antiviral Agents / Q000627:therapeutic use; D002051:Burkitt Lymphoma / Q000209:etiology / Q000821:virology; D002648:Child; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006689:Hodgkin Disease / Q000209:etiology / Q000821:virology; D006801:Humans; D016219:Immunotherapy, Adoptive; D008223:Lymphoma / Q000209:etiology* / Q000821:virology; D016393:Lymphoma, B-Cell / Q000209:etiology / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000821:virology
D000998:Antiviral Agents