title: Sweet taste-induced analgesia: an fMRI study.
abstract: We investigated the brain activation associated with sweet taste-induced analgesia by 3-T functional magnetic resonance imaging, the mechanism of which is considered to involve the central nervous system. After 12 healthy individuals ingested tasteless gelatin (nonsweet condition) or sweet glucose (sweet condition) in a magnetic resonance imaging scanning gantry, the cold pressor test was applied to their medial forearm. Under both conditions, the cold pressor test robustly activated the pain-related neural network, notably the anterior cingulate cortex, insula, posterior parietal cortex, and thalamus, although such activations under the sweet condition weakened with pain threshold increase, compared with those under the nonsweet condition. Together with emotional changes in pain appraisal, our findings provide objective representation of sweet taste-induced analgesia in the human brain.
authors.affiliation: Department of Nursing, Faculty of Health and Welfare, Kawasaki University of Medical Welfare, Matsuyama, Kurashiki, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kakeda
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Ogino
authors.forename: Fumio
authors.initials: F
authors.lastname: Moriya
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saito
mesh_terms: D000328:Adult; D000698:Analgesia / Q000379:methods*; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D010146:Pain / Q000503:physiopathology*; D059408:Pain Management; D010812:Physical Stimulation / Q000379:methods; D013549:Sweetening Agents / Q000494:pharmacology* / Q000627:therapeutic use; D013649:Taste / Q000502:physiology*; D055815:Young Adult
chemical_list: D013549:Sweetening Agents