title: Oral-facial-digital syndrome type 1: oral features in 12 patients submitted to clinical and radiographic examination.
abstract: OBJECTIVE
  To evaluate the oral features in individuals with oral-facial-digital syndrome type 1 (OFD 1), previously diagnosed by the Genetic Sector of the Hospital of Rehabilitation of Craniofacial Anomalies of the University of São Paulo (HRAC-USP).
  
  
  METHODS
  Twelve patients with OFD 1 were examined clinically and radiographically; their medical files were also evaluated.
  
  
  RESULTS
  Associated oral malformations were observed in all patients (100%). The most frequent findings were tongue hamartomas, multiple buccal frena, asymmetric lips, asymmetric tongue, and bilateral maxillary gingival swelling. Interestingly, atrophy of the maxillary midline frenum was also observed in all the individuals examined.
  
  
  CONCLUSIONS
  Several extra and intraoral alterations were observed in patients with OFD 1. The authors suggest the inclusion of atrophy of the maxillary midline frenum as a commonly found characteristic of OFD 1.
authors.affiliation: Pediatric Dentistry Sector, FOAr/UNESP, Bauru, SP, Brazil.
authors.forename: Marcela Martini
authors.initials: MM
authors.lastname: Tagliani
authors.forename: Marcia Ribeiro
authors.initials: MR
authors.lastname: Gomide
authors.forename: Cleide Felício Carvalho
authors.initials: CF
authors.lastname: Carrara
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002971:Cleft Lip / Q000209:etiology; D002972:Cleft Palate / Q000000981:diagnostic imaging / Q000209:etiology; D005260:Female; D006801:Humans; D007742:Labial Frenum / Q000002:abnormalities*; D008310:Malocclusion / Q000209:etiology; D009056:Mouth Abnormalities / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D009958:Orofaciodigital Syndromes / Q000000981:diagnostic imaging / Q000473:pathology*; D011859:Radiography; D014071:Tooth Abnormalities / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D055815:Young Adult