Nanonization strategies for poorly water-soluble drugs.
Poor water solubility for many drugs and drug candidates remains a major obstacle to their development and clinical application. Conventional formulations to improve solubility suffer from low bioavailability and poor pharmacokinetics, with some carriers rendering systemic toxicities (e.g. Cremophor(®) EL). In this review, several major nanonization techniques that seek to overcome these limitations for drug solubilization are presented. Strategies including drug nanocrystals, nanoemulsions and polymeric micelles are reviewed. Finally, perspectives on existing challenges and future opportunities are highlighted.
Chen
Huabing
H
Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Khemtong
Chalermchai
C
Yang
Xiangliang
X
Chang
Xueling
X
Gao
Jinming
J
D001682:Biological Availability; D004337:Drug Carriers; D006801:Humans; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000737:chemistry* / Q000378:metabolism; D012995:Solubility; D014867:Water
D004337:Drug Carriers; D008823:Micelles; D004364:Pharmaceutical Preparations; D014867:Water