title: Toward optimized front-line therapeutic strategies in patients with metastatic colorectal cancer--an expert review from the International Congress on Anti-Cancer Treatment (ICACT) 2009.
abstract: Metastatic colorectal cancer is a particularly frequent and severe cancer. Patients die mainly from metastatic disease; however, the survival of these patients has dramatically improved with the progress in chemotherapeutic regimens as new routes of administration and introduction of more potent cytotoxic agents administered in sequential 5-FU-folinic acid-irinotecan/5-FU-folinic acid-oxaliplatine strategies. Biologic therapies have been also developed targeting two different pathways, angiogenesis and the epidermal growth factor receptor. Their combination with chemotherapy leads to improved progression-free survival and overall survival in some cases as the addition of cetuximab in wild-type K-Ras tumors. The objectives of this expert conference were to review the different options, the available prognostic or predictive factors to optimally guide the treatment.
authors.affiliation: Centre Hépato-Biliaire, Assistance Publique-Hôpitaux de Paris Hôpital Paul Brousse, and University Paris-Sud, Unité Mixte de Recherche-S 776 and Institut National de la Santé et de la Recherche Médicale, Unité 776, Villejuif, France. Electronic address: rene.adam@pbr.aphp.fr.
authors.forename: R
authors.initials: R
authors.lastname: Adam
authors.affiliation: Abramson Cancer Center, University of Pennsylvania, PA, USA.
authors.forename: D G
authors.initials: DG
authors.lastname: Haller
authors.affiliation: Centre for Digestive Diseases, Aintree University Hospital, Liverpool, UK.
authors.forename: G
authors.initials: G
authors.lastname: Poston
authors.affiliation: Department of Medical Oncology, Centre Eugene Marquis, Rennes.
authors.forename: J-L
authors.initials: JL
authors.lastname: Raoul
authors.affiliation: Service d'Oncologie Médicale, Groupe Hospitalier Pitie-salpetriere, Paris, France.
authors.forename: J-P
authors.initials: JP
authors.lastname: Spano
authors.affiliation: Medical Oncology Department, Vall d'Hebron University Hospital, Barcelona, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Tabernero
authors.affiliation: Digestive Oncology Unit, University Hospital Gasthuisberg, Leuven, Belgium.
authors.forename: E
authors.initials: E
authors.lastname: Van Cutsem
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001688:Biological Products / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D006801:Humans; D009362:Neoplasm Metastasis; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products