title: Alphaherpesvirus use and misuse of cellular actin and cholesterol.
abstract: Two major structural elements of a cell are the cytoskeleton and the lipid membranes. Actin and cholesterol are key components of the cytoskeleton and membranes, respectively, and are involved in a plethora of different cellular processes. This review summarizes and discusses the interaction of alphaherpesviruses with actin and cholesterol during different stages of the replication cycle: virus entry, replication and assembly in the nucleus, and virus egress. Elucidating these interactions not only yields novel insights into the biology of these important pathogens, but may also shed new light on cell biological aspects of actin and cholesterol, and lead to novel avenues in the design of antiviral strategies.
authors.affiliation: Department of Virology, Parasitology, and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. Herman.Favoreel@UGent.be
authors.forename: Herman W
authors.initials: HW
authors.lastname: Favoreel
authors.forename: Céline
authors.initials: C
authors.lastname: Van den Broeke
authors.forename: Ann
authors.initials: A
authors.lastname: Desplanques
authors.forename: Matthias
authors.initials: M
authors.lastname: Deruelle
authors.forename: Geert
authors.initials: G
authors.lastname: Van Minnebruggen
authors.forename: Hans
authors.initials: H
authors.lastname: Nauwynck
authors.forename: Sarah
authors.initials: S
authors.lastname: Glorieux
authors.forename: Nina
authors.initials: N
authors.lastname: Van Opdenbosch
authors.forename: Nick
authors.initials: N
authors.lastname: De Regge
mesh_terms: D000199:Actins / Q000378:metabolism*; D018138:Alphaherpesvirinae / Q000502:physiology*; D000818:Animals; D002467:Cell Nucleus / Q000821:virology; D002784:Cholesterol / Q000378:metabolism*; D003599:Cytoskeleton / Q000821:virology; D004261:DNA Replication; D006566:Herpesviridae Infections / Q000821:virology*; D054884:Host-Pathogen Interactions; D006801:Humans; D019065:Virus Assembly; D053586:Virus Internalization; D057074:Virus Release
chemical_list: D000199:Actins; D002784:Cholesterol