Adrenocortical development and cancer: focus on SF-1.
Steroidogenic factor-1 (SF-1/Ad4-binding protein; NR5A1) is an essential regulator of tissue-specific gene expression in steroidogenic cells and of adrenogonadal development. Here, I discuss recent data in the literature showing the implication of SF-1 and the importance of its dosage not only during development but also for adrenal cortex tumorigenesis in humans and mice.
Lalli
Enzo
E
Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR 6097, 660 route des Lucioles, Sophia Antipolis, 06560 Valbonne, France. ninino@ipmc.cnrs.fr
D000306:Adrenal Cortex Neoplasms / Q000235:genetics / Q000378:metabolism*; D000311:Adrenal Glands / Q000254:growth & development*; D000328:Adult; D000818:Animals; D004742:Enhancer Elements, Genetic; D005260:Female; D018398:Homeodomain Proteins / Q000235:genetics / Q000502:physiology; D006801:Humans; D008297:Male; D051379:Mice; D011401:Promoter Regions, Genetic; D054339:Steroidogenic Factor 1 / Q000235:genetics / Q000502:physiology*
D018398:Homeodomain Proteins; D054339:Steroidogenic Factor 1