Visualization of macromolecular structures.
Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools.
O'Donoghue
Seán I
SI
European Molecular Biology Laboratory, Heidelberg, Germany. sean.odonoghue@embl.de
Goodsell
David S
DS
Frangakis
Achilleas S
AS
Jossinet
Fabrice
F
Laskowski
Roman A
RA
Nilges
Michael
M
Saibil
Helen R
HR
Schafferhans
Andrea
A
Wade
Rebecca C
RC
Westhof
Eric
E
Olson
Arthur J
AJ
D018360:Crystallography, X-Ray; D007091:Image Processing, Computer-Assisted; D020407:Internet; D046911:Macromolecular Substances; D008958:Models, Molecular; D008968:Molecular Conformation
D046911:Macromolecular Substances