CD4 T cell count reconstitution in HIV controllers after highly active antiretroviral therapy.
Sixty-two human immunodeficiency virus (HIV) controllers (6 elite and 56 viremic controllers) in the US Military Department of Defense HIV Natural History Study cohort initiated highly active antiretroviral therapy (HAART) and achieved statistically significant mean CD4 cell count increases, although the gains were lower than those in treated noncontrollers. HIV controllers experienced CD4 cell count reconstitution with HAART regardless of pretherapy viral load, including patients with undetectable viral loads at HAART initiation.
Okulicz
Jason F
JF
Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, National Naval Medical Center, Bethesda, Maryland, USA. Jason.okulicz@amedd.army.mil
Grandits
Greg A
GA
Weintrob
Amy C
AC
Landrum
Michael L
ML
Ganesan
Anuradha
A
Crum-Cianflone
Nancy F
NF
Agan
Brian K
BK
Marconi
Vincent C
VC
D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D008297:Male; D014481:United States; D019562:Viral Load; D055815:Young Adult
D019380:Anti-HIV Agents