To asses the effects of rocuronium pretreatment on succinylcholine induced fasciculations and postoperative myalgias.
OBJECTIVE
To asses the effects of Rocuronium pretreatment on Succinylcholine induced Fasciculations and postoperative Myalgias.


METHODS
A randomized double blind case control study was conducted in Department of Anaesthesia and Surgical Intensive Care Unit, Liaquat National Hospital, Karachi from October 2003 - April 2004. Sixty adults ASA I or II patients who presented for elective general surgical procedures were included in the study. The patients were divided in two groups of thirty each by a simple lottery method. Group "A" received placebo and group "B" received Rocuronium 0.1 mg/kg, one minute prior to induction with Pentothal Sodium 5 mg/kg, Suxamethonium, 1.5 mg/kg and Nalbuphine 10 mg / 70 kg. Fasciculations and intubation condition was assessed immediately after the induction of anaesthesia while post operative myalgias were assessed 6, 12 and 24 hours after surgery.


RESULTS
Fasciculations were noticed in group "A" as 100% (mild to severe) and in group "B" 13.3% (mild). Post operative myalgias at 6 and 12 hours after surgery were 76.66 % in group "A" and 16.66 in groups "B". After 24 hours in group "A' post operative myalgias were 93.33% and group "B" 23.33%.


CONCLUSIONS
It is concluded that pretreatment with Rocuronium reduced the incidence of myalgias, fasciculations and produced rapid precurarization in one minute thereby saving time on busy operating lists. They also allowed the early ambulation of patients in minor surgeries.
Abbas
Nighat
N
Department of Anaesthesia, Liaquat National Hospital, Karachi.
Tariq
Sabahat
S
Khan
Akhtar Waheed
AW
Murtaza
Ghulam
G
Naqvi
Nadeem
N
Khanzada
Arshad
A
D000293:Adolescent; D000328:Adult; D000732:Androstanols / Q000627:therapeutic use*; D004311:Double-Blind Method; D005207:Fasciculation / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000517:prevention & control*; D009467:Neuromuscular Depolarizing Agents / Q000009:adverse effects*; D003473:Neuromuscular Nondepolarizing Agents / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000517:prevention & control; D000077123:Rocuronium; D013390:Succinylcholine / Q000009:adverse effects*; D055815:Young Adult
D000732:Androstanols; D009467:Neuromuscular Depolarizing Agents; D003473:Neuromuscular Nondepolarizing Agents; D013390:Succinylcholine; D000077123:Rocuronium