title: Sex hormones, insulin resistance and high-density lipoprotein cholesterol levels in children.
abstract: Cardiovascular risk starts early in life; therefore, it is of interest to clarify the relation between puberty, sex hormones, insulin resistance and lipid levels in children. This is a cross sectional study of 365 school students (8-18 years of age). We analyzed the associations of sex hormones (testosterone, free androgen index, estradiol, free estradiol index) and sex hormone-binding globulin (SHBG) with insulin resistance and lipid levels. Analyses were performed in prepubertal versus adolescent girls and boys. Among prepubertal boys, estradiol was significantly associated with increased log homeostasis model assessment-estimated insulin resistance (HOMA-IR; B = 0.9, model R(2) = 0.62, p < 0.001) and insulin levels (B = 0.8, model R(2) = 0.58, p < 0.001). Testosterone was associated with increased high-density lipoprotein cholesterol (HDL-C) levels among prepubertal boys (B = 10, model R(2) = 0.42, p = 0.04). Among adolescent girls, SHBG was significantly associated with decreased HOMA-IR (B = -0.8, model R(2) = 0.34, p = 0.01) and insulin levels (B = -0.7, model R(2) = 0.34, p = 0.01). SHBG was also related to increased HDL-C levels among prepubertal (B = 24, model R(2) = 0.42, p = 0.047) and adolescent girls (B = 21, model R(2) = 0.44, p = 0.002). In conclusion, sex hormone levels and SHBG have important effects on HDL-C and insulin resistance among children and adolescents.
authors.affiliation: Department of Cardiology, Marmara University School of Medicine, Istanbul, Turkey. magirbasli@gmail.com
authors.forename: Mehmet
authors.initials: M
authors.lastname: Agirbasli
authors.forename: Nihat Bugra
authors.initials: NB
authors.lastname: Agaoglu
authors.forename: Nilay
authors.initials: N
authors.lastname: Orak
authors.forename: Hatice
authors.initials: H
authors.lastname: Caglioz
authors.forename: Tuba
authors.initials: T
authors.lastname: Ocek
authors.forename: Turgut
authors.initials: T
authors.lastname: Karabağ
authors.forename: Oytun A
authors.initials: OA
authors.lastname: Baykan
mesh_terms: D000293:Adolescent; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood*; D003430:Cross-Sectional Studies; D004958:Estradiol; D005260:Female; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006331:Heart Diseases / Q000209:etiology; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood*; D008297:Male; D011627:Puberty / Q000502:physiology; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*; D013739:Testosterone
chemical_list: D008076:Cholesterol, HDL; D012739:Gonadal Steroid Hormones; D008055:Lipids; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol