title: [Study on stabilized hyaluronic acid-based gel of non-animal origin for the correction of nasolabial folds].
abstract: OBJECTIVE
  To assess the safety and efficacy of hyaluronic acid-based gel of non-animal origin (NASHA gel [Restylane]; Q-Med AB, Uppsala, Sweden)for correcting nasolabial folds in Chinese.
  
  
  METHODS
  Patients with moderate or severe nasolabial fold (Wrinkle Severity Rating Scale, WSRS) were recruited to receive NASHA gel injection ( < 1.5 ml). The patients were followed up for 6 months. The efficacy was assessed by physicians and patients, respectively. Adverse events (AEs) were recorded and laboratory tests were performed before and after operation.
  
  
  RESULTS
  86 patients were treated. 6 months after injection, improved esthetic results was assessed by patients and physicians independently. 52 AEs happened in 32 cases (37.2%). Most of them were local injection reaction and minor, which were recovered spontaneously. No systemic reaction was found.
  
  
  CONCLUSIONS
  NASHA gel can improve the nasolabial folds. It is very safe and tolerated.
authors.affiliation: Division of Plastic Surgery, Clinical Department of Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Xiao-qing
authors.initials: XQ
authors.lastname: Yan
authors.forename: Lei
authors.initials: L
authors.lastname: You
authors.forename: Li-yang
authors.initials: LY
authors.lastname: Chen
authors.forename: Yong-guang
authors.initials: YG
authors.lastname: Ma
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Huang
authors.forename: Chang-sheng
authors.initials: CS
authors.lastname: Lo
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Xu
mesh_terms: D000328:Adult; D044466:Asian People; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015361:Rhytidoplasty / Q000379:methods*; D015595:Skin Aging; D055815:Young Adult
chemical_list: D006820:Hyaluronic Acid; C445361:Restylane