Synthesis and anti-inflammatory activity of some novel biphenyl-4-carboxylic acid 5-(arylidene)-2-(aryl)-4-oxothiazolidin-3-yl amides.
Some new biphenyl-4-carboxylic acid 5-(arylidene)-2-(aryl)-4-oxothiazolidin-3-yl amides have been synthesized and evaluated for anti-inflammatory activity. Biphenyl-4-carboxylic acid hydrazide was converted to the corresponding aryl hydrazones using aryl aldehydes in the presence of catalytic amount of glacial acetic acid. The aryl hydrazones on reaction with thioglycolic acid in the presence of anhydrous zinc chloride yielded the biphenyl-4-carboxylic acid 2-(aryl)-4-oxothiazolidin-3-yl amides, which again on reaction with aromatic aldehydes in the presence of anhydrous sodium acetate and glacial acetic acid furnished the title compounds. The structures of all these newly synthesized compounds were confirmed by their analytical and spectral data which were in full agreement with proposed structures. All compounds were screened for anti-inflammatory activity employing carrageenan test at the dose of 10 mg/kg and exhibited significant activities.
Deep
Aakash
A
Department of Pharmaceutical Sciences, G.V.M. College of Pharmacy, Sonepat -131001, India.
Jain
Sandeep
S
Sharma
Prabodh Chander
PC
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D004195:Disease Models, Animal; D005260:Female; D007249:Inflammation / Q000139:chemically induced / Q000517:prevention & control; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D013844:Thiazoles; D002351:Carrageenan