Impulsive-compulsive spectrum behaviors in pathologically confirmed progressive supranuclear palsy.
There is growing awareness of impulsive-compulsive spectrum behaviors (ICBs) in patients with Parkinson's disease (PD) treated with dopamine replacement therapy (DRT). These include pathological gambling, hypersexuality, compulsive shopping, binge eating, punding and compulsive use of DRT, or dopamine dysregulation syndrome. In PD, difficulties exist in separating the effects of DRT from the underlying disease process and aberrant dopaminergic systems in determining the aetiology of ICBs. Recent reports of ICBs associated with dopamine agonist use for conditions other than PD may suggest a significant etiological role for these medications, but currently published cases thus far lack pathological confirmation of diagnoses. We present three cases of pathologically confirmed progressive supranuclear palsy who developed ICBs in association with dopamine agonist use. Pathological comparisons between these three cases and other case series of progressive supranuclear palsy are made.
O'Sullivan
Sean S
SS
Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, University College London, London, United Kingdom.
Djamshidian
Atbin
A
Ahmed
Zeshan
Z
Evans
Andrew H
AH
Lawrence
Andrew D
AD
Holton
Janice L
JL
Revesz
Tamas
T
Lees
Andrew J
AJ
D000368:Aged; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000209:etiology*; D004298:Dopamine / Q000378:metabolism; D015259:Dopamine Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D013494:Supranuclear Palsy, Progressive / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*
D015259:Dopamine Agents; D004298:Dopamine