title: Genetics of inflammasome-associated disorders: a lesson in the guiding principals of inflammasome function.
abstract: Human genetics research has had a great impact on the genesis of the inflammasome field and the treatment of certain inflammasomopathies. The identification of mutations causing rare autoinflammatory syndromes, reproductive wastage disorders and of single nucleotide polymorphisms influencing susceptibility to complex diseases such as vitiligo, sepsis, and Crohn's disease has not only led to the characterization of novel proteins involved in NOD-like receptor-coupled inflammatory signaling pathways but also to greater insights into pathogenic mechanisms.
authors.affiliation: Department of Medicine, McGill University, Montréal, Canada.
authors.forename: Ian Gaël
authors.initials: IG
authors.lastname: Rodrigue-Gervais
authors.forename: Maya
authors.initials: M
authors.lastname: Saleh
mesh_terms: D000818:Animals; D015551:Autoimmunity / Q000235:genetics / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007154:Immune System Diseases / Q000235:genetics* / Q000276:immunology; D007249:Inflammation / Q000235:genetics* / Q000276:immunology; D046912:Multiprotein Complexes / Q000235:genetics* / Q000276:immunology
chemical_list: D046912:Multiprotein Complexes