title: The Golgi and the centrosome: building a functional partnership.
abstract: The mammalian Golgi apparatus is characterized by a ribbon-like organization adjacent to the centrosome during interphase and extensive fragmentation and dispersal away from the centrosome during mitosis. It is not clear whether this dynamic association between the Golgi and centrosome is of functional significance. We discuss recent findings indicating that the Golgi-centrosome relationship may be important for directional protein transport and centrosome positioning, which are both required for cell polarization. We also summarize our current knowledge of the link between Golgi organization and cell cycle progression.
authors.affiliation: Department of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA. suetterc@uci.edu
authors.forename: Christine
authors.initials: C
authors.lastname: Sütterlin
authors.forename: Antonino
authors.initials: A
authors.lastname: Colanzi
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D016764:Cell Polarity; D018385:Centrosome / Q000378:metabolism*; D006056:Golgi Apparatus / Q000737:chemistry / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D021381:Protein Transport; D008941:Spindle Apparatus / Q000378:metabolism