title: First clinical results of epithelial laser in situ keratomileusis with a 1000 Hz excimer laser.
abstract: OBJECTIVE
  To evaluate the safety, stability, and efficacy of the first clinical cases of epithelial laser in situ keratomileusis (epi-LASIK) performed using a 1000 Hz excimer laser system.
  
  
  METHODS
  Klinikum Rechts der Isar, Munich, Germany.
  
  
  METHODS
  The epi-LASIK procedure was performed using an EpiLift microkeratome and a WaveLight Concept System 1000 laser. Preoperatively and 1, 3, and 6 months postoperatively, a complete ophthalmic examination was performed. The examination included objective and subjective refraction, uncorrected and corrected distance visual acuities, and topography.
  
  
  RESULTS
  The study comprised 30 eyes of 17 patients. The mean spherical equivalent was -4.36 diopters (D) +/-1.77 (SD) preoperatively, 0.07 +/- 0.38 D 1 month postoperatively, -0.06 D +/- 0.25 D at 3 months, and -0.05 +/- 0.24 D at 6 months. Six months postoperatively, 90% of patients were within +/-0.50 D of the intended correction and all were within +/-1.00 D. At 3 months, 25 eyes had a clear cornea and 5 eyes had trace haze.
  
  
  CONCLUSIONS
  In this pilot series, the use of the 1000 Hz excimer laser did not lead to the clinical side effects that are potentially associated with the use of a high repetition rate. The safety, stability, and efficacy of the laser were high although no adjustments to the nomogram were made.
authors.affiliation: Augenklinik Klinikum Rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675 Munich, Germany. christoph.wvm@gmail.com
authors.forename: Christoph
authors.initials: C
authors.lastname: Winkler von Mohrenfels
authors.forename: Ramin
authors.initials: R
authors.lastname: Khoramnia
authors.forename: Christian
authors.initials: C
authors.lastname: Wüllner
authors.forename: Christof
authors.initials: C
authors.lastname: Donitzky
authors.forename: Josefina
authors.initials: J
authors.lastname: Salgado
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Pfäffl
authors.forename: Chris-Patrick
authors.initials: CP
authors.lastname: Lohmann
mesh_terms: D000328:Adult; D019781:Corneal Topography; D004869:Equipment Safety; D005260:Female; D006801:Humans; D007431:Intraoperative Complications; D020731:Keratomileusis, Laser In Situ / Q000295:instrumentation*; D054018:Lasers, Excimer; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000601:surgery*; D010865:Pilot Projects; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult