[Portal hypertension in patients with inflammatory bowel disease].
Portal hypertension (PH) is a complication that may occur in patients with inflammatory bowel disease (IBD). In these patients, the etiology of PH may not be alcoholic or viral cirrhosis (which cause 90% of cases in the general population). Consequently, etiologic study of PH in patients with IBD should always include a wide spectrum of possibilities. Moreover, the development of PH in IBD patients often requires a distinct therapeutic approach to IBD (both medical and surgical) as PH may be a contraindication for some drugs and is a risk factor for surgical morbidity and mortality. We present the cases of two patients with IBD who developed PH and review the most likely causes of PH in IBD, as well as preventive and therapeutic strategies.
Leal-Valdivieso
Carles
C
Servicio de Aparato Digestivo, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, España.
Naves
Juan E
JE
Mañosa
Míriam
M
Zabana
Yamile
Y
Cabré
Eduard
E
Domènech
Eugeni
E
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D001171:Arthritis, Juvenile / Q000150:complications / Q000188:drug therapy; D001201:Ascites / Q000209:etiology; D003424:Crohn Disease / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology* / Q000503:physiopathology; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D015212:Inflammatory Bowel Diseases / Q000150:complications / Q000188:drug therapy; D007418:Intestinal Pseudo-Obstruction / Q000209:etiology; D008103:Liver Cirrhosis / Q000139:chemically induced; D019804:Mesalamine / Q000627:therapeutic use; D008642:Mesenteric Veins / Q000473:pathology; D008727:Methotrexate / Q000009:adverse effects / Q000627:therapeutic use; D013163:Splenomegaly / Q000209:etiology; D013866:Thioguanine / Q000627:therapeutic use; D019851:Thrombophilia / Q000209:etiology; D014648:Varicose Veins / Q000209:etiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007166:Immunosuppressive Agents; D019804:Mesalamine; D013866:Thioguanine; D008727:Methotrexate