[Aspects of practical diagnosis in perinatal post-hypoxic cardiomiopathy].
Retrospectively the Perinatal Post-Hypoxic Cardiac disorder, was researched in 32 newborn (ages 0-14 days), having a normal weight, with hypoxia at birth, Apgar score 3-7, requiring resuscitation at birth. The patients did not show signs of major cardiac suffering, except a systolic murmur, the neurologic manifestations prevailing.


RESULTS
The investigations showed: cardiomegaly (46.9%); ECG: repolarization disorders of the left ventricle (LV) (43.5%); echocardiographic modifications in 67.2% of cases, mainly hypertrophic cardiomyopathy with septal predominance (59.3%) and LV diastolic dysfunction. The treatment with spironolactone generated the significant decrease of the septal myocardial hypertrophy and of the tricuspidien insufficiency, with the normalization of the LV diastolic function.


CONCLUSIONS
The echocardiographic examination, as the main method of diagnosis and follow up of the cardiomiopathy induced by the perinatal hypoxia has to be performed right in the 1st week of life and later on up to the cure of the morphologic and functional cardiac modifications.
Mitrea
Geta
G
Secţia Nou Născuţi, Spitalul Judeţean Galaţi, Facultatea de Medicină, Universitatea de Medicină si Farmacie Gr.T. Popa Iaşi
Dimitriu
A G
AG
Stamatin
Maria
M
D001238:Asphyxia Neonatorum / Q000150:complications*; D006332:Cardiomegaly / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D003937:Diagnosis, Differential; D003971:Diastole; D004232:Diuretics / Q000627:therapeutic use; D015150:Echocardiography, Doppler; D004562:Electrocardiography; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013148:Spironolactone / Q000627:therapeutic use; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology
D004232:Diuretics; D013148:Spironolactone