title: Enhanced fluorescence of curcumin on plasmonic platforms.
abstract: We report a significant increase of a curcumin (1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione) fluorescence brightness when deposited on plasmonic platforms (self assembled silver nanostructures formed on the surface of silver semitransparent film). The enhancement of fluorescence intensity is accompanied by a strong decrease in fluorescence lifetime. Simultaneously, the increased photostability of curcumin, a pigment showing strong anti-inflammatory, antioxidant and antitumorigenic activity, allows long-time detection and monitoring. We believe that the use of plasmonic platforms will improve detection, delivery and imaging of curcumin.
authors.affiliation: Dept. of Molecular Biology & Immunology and Institute of the Cancer Research, UNTHSC, Fort Worth, TX 76107, USA.
authors.forename: Anindita
authors.initials: A
authors.lastname: Mukerjee
authors.forename: Rafal
authors.initials: R
authors.lastname: Luchowski
authors.forename: Amalendu P
authors.initials: AP
authors.lastname: Ranjan
authors.forename: Sangram
authors.initials: S
authors.lastname: Raut
authors.forename: Jamboor K
authors.initials: JK
authors.lastname: Vishwanatha
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Gryczynski
authors.forename: Ignacy
authors.initials: I
authors.lastname: Gryczynski
mesh_terms: D003474:Curcumin / Q000032:analysis* / Q000737:chemistry; D005453:Fluorescence; D005898:Glass; D018625:Microscopy, Atomic Force; D008856:Microscopy, Fluorescence; D015394:Molecular Structure; D049329:Nanostructures / Q000737:chemistry*; D055668:Photochemical Processes; D011142:Polyvinyl Alcohol / Q000737:chemistry; D012834:Silver / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D020349:Surface Plasmon Resonance / Q000295:instrumentation / Q000379:methods*
chemical_list: D012834:Silver; D011142:Polyvinyl Alcohol; D003474:Curcumin