[Muscle-derived stem cell therapy for stress urinary incontinence].
The knowledge of the urinary effort incontinence (UEI) has increased, giving like result an ample range of different therapeutic options available. The middle urethra and external urethral sphincter are the focus in management of UEI. Stem cells therapy for the regenerative repair of the deficient sphincter has been the leading research of incontinence. Obtaining autologous myoblasts and fibroblasts of skeletal muscle-biopsies, cultivating them and transplanting them after its differentiation, into the external urethral sphincter it warns a new concept in the treatment of the incontinence. Instead of using heterologous materials such as synthetic mesh (slings) or bulking agents (collagen, silicone, etc); we now have the potential to restore function with the use of autologous stem cells.
Proaño
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AR
División de Urología, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Argentina. soninonino@hotmail.com
Medrano
A
A
Garrido
G
G
Mazza
O
O
D053687:Adult Stem Cells / Q000637:transplantation*; D001706:Biopsy; D002469:Cell Separation / Q000379:methods; D002478:Cells, Cultured / Q000637:transplantation; D002986:Clinical Trials as Topic; D005260:Female; D005347:Fibroblasts / Q000637:transplantation*; D006801:Humans; D008297:Male; D039902:Multipotent Stem Cells / Q000637:transplantation*; D018482:Muscle, Skeletal / Q000166:cytology*; D032446:Myoblasts / Q000637:transplantation*; D016032:Randomized Controlled Trials as Topic; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D014463:Ultrasonography; D014550:Urinary Incontinence, Stress / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery*; D013520:Urologic Surgical Procedures / Q000379:methods*