[Increased level of prostate-specific antigen: a diagnostic marker of hyperandrogenism women].
OBJECTIVE
To determine whether the increased level of serum prostate-specific antigen (PSA) could be used as a diagnostic marker of hyperandrogenism in women.


METHODS
Forty-five female patients with hyperandrogenism and 50 healthy control women were detected for the levels of serum PSA, testosterone (T), sex hormone binding globulin (SHBG) and dehydroepiandrosterone sulfate (DHEA-S). The results were statistically analyzed.


RESULTS
The level of serum PSA was found to be significantly higher in the hyperandrogenism patients than in the healthy controls (9.72 +/- 1.39 pg/ml vs 3.56 +/- 0.44 pg/ml, P < 0.01), and it showed a weak positive correlation with T (r = 0.226, P < 0.05) and DHEA-S (r = 0.255, P < 0.05), and a weak negative correlation with SHBG (r = -0,228, P < 0.05).


CONCLUSIONS
The increased level of PSA could be used as a diagnostic marker of hyperandrogenism in females.
Wang
Guo-Hong
GH
PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Military Region, Nanjing, Jiangsu 210002, China. ghw54321@sina.com
Xu
Rui-Ji
RJ
Zhang
Zhong-Shu
ZS
D000328:Adult; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood* / Q000175:diagnosis*; D017430:Prostate-Specific Antigen / Q000097:blood*; D012738:Sex Hormone-Binding Globulin; D055815:Young Adult
D012738:Sex Hormone-Binding Globulin; D017430:Prostate-Specific Antigen