Parvovirus 4-like virus in blood products.
Porcine plasma and factor VIII preparations were screened for parvovirus 4 (PARV)-like viruses. Although the prevalence of PARV4-like viruses in plasma samples was relatively low, viruses appeared to be concentrated during manufacture of factor VIII. PARV4-like viruses from human and porcine origins coevolved likewise with their hosts.
Szelei
Jozsef
J
Institut National de la Recherche Scientifique-Institut Armand-Frappier, Laval, Quebec, Canada.
Liu
Kaiyu
K
Li
Yi
Y
Fernandes
Sandra
S
Tijssen
Peter
P
D000818:Animals; D001688:Biological Products / Q000032:analysis* / Q000097:blood; D004279:DNA, Viral / Q000032:analysis; D005169:Factor VIII / Q000032:analysis* / Q000627:therapeutic use; D006801:Humans; D010322:Parvoviridae Infections / Q000097:blood* / Q000821:virology; D017992:Parvovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D010949:Plasma / Q000821:virology*; D017422:Sequence Analysis, DNA; D013552:Swine; D013553:Swine Diseases / Q000821:virology
D001688:Biological Products; D004279:DNA, Viral; D005169:Factor VIII