title: Altered hyaluronan biosynthesis and cancer progression: an immunological perspective.
abstract: Hyaluronan is a glycosaminglycan present in practically all tissues as an important component of the extracellular matrix. In spite of its apparent simple chemical structure, hyaluronan is a molecule with multiple and complex physiogical and pathological functions, Hyaluronan is able to regulate a variety of biological processes such as cellular growth, migration, differentiation and inflammation, not only in normal but also in cancer tissues. Besides, increasing evidence suggests hyaluronan as a potent modulator of immune responses which supports a potential role of this molecule in cancer immunotherapy.
authors.affiliation: Gene Therapy Laboratory, School of Medicine, Austral University, Avenida Presidente Perón 1500 (B1629ODT) Derqui-Pilar, Buenos Aires, Argentina.
authors.forename: Laura
authors.initials: L
authors.lastname: Alaniz
authors.forename: Mariana
authors.initials: M
authors.lastname: Garcia
authors.forename: Miguel
authors.initials: M
authors.lastname: Rizzo
authors.forename: Flavia
authors.initials: F
authors.lastname: Piccioni
authors.forename: Guillermo
authors.initials: G
authors.lastname: Mazzolini
mesh_terms: D018450:Disease Progression; D006801:Humans; D006820:Hyaluronic Acid / Q000096:biosynthesis* / Q000502:physiology; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology
chemical_list: D006820:Hyaluronic Acid