Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice.
Dendritic cells (DCs) have been extensively studied in mice lymphoid organs, but less is known about the origin and the mechanisms that regulate DC development and function in non-lymphoid tissues. Here, we discuss recent evidence establishing the contribution of the DC-restricted lineage to the non-lymphoid tissue DC pool and discuss the mechanisms that control the homeostasis of non-lymphoid tissue DCs. We also review recent results underlining the functional specialization of tissue DCs and discuss the potential implications of these findings in tissue immunity and in the development of novel vaccine strategies.
Helft
Julie
J
Department of Gene and Cell Medicine and Mount Sinai School of Medicine, New York, NY, USA.
Ginhoux
Florent
F
Bogunovic
Milena
M
Merad
Miriam
M
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D019070:Cell Lineage / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology* / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000276:immunology* / Q000378:metabolism; D006706:Homeostasis; D018836:Inflammation Mediators / Q000276:immunology; D051379:Mice; D010641:Phenotype; D014157:Transcription Factors / Q000378:metabolism; D014612:Vaccines / Q000276:immunology
D016207:Cytokines; D018836:Inflammation Mediators; D014157:Transcription Factors; D014612:Vaccines