Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging.
We develop a novel dual-modal contrast agent-encapsulated-ink poly(lactic-co-glycolic acid) (PLGA) microbubbles and nanobubbles-for photoacoustic and ultrasound imaging. Soft gelatin phantoms with embedded tumor simulators of encapsulated-ink PLGA microbubbles and nanobubbles in various concentrations are clearly shown in both photoacoustic and ultrasound images. In addition, using photoacoustic imaging, we successfully image the samples positioned below 1.8-cm-thick chicken breast tissues. Potentially, simultaneous photoacoustic and ultrasound imaging enhanced by encapsulated-dye PLGA microbubbles or nanobubbles can be a valuable tool for intraoperative assessment of tumor boundaries and therapeutic margins.
Kim
Chulhong
C
Qin
Ruogu
R
Xu
Jeff S
JS
Wang
Lihong V
LV
Xu
Ronald
R
D000818:Animals; D002645:Chickens; D003287:Contrast Media / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry; D045423:Microbubbles; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D019047:Phantoms, Imaging; D011100:Polyglycolic Acid / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D014463:Ultrasonography / Q000379:methods*
D003287:Contrast Media; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid