title: Daidzein-metabolising phenotypes in relation to serum lipids and uric acid in adults in Guangzhou, China.
abstract: Previous studies have suggested that daidzein's metabolites, equol and O-desmethylangolensin (O-DMA), rather than daidzein itself may contribute to the beneficial effects of soya foods in the prevention of CVD. The present study aims to assess the proportion of equol and O-DMA producers, and to compare differences in anthropometric factors, serum lipids, glucose and uric acid between producers and non-producers in Chinese adults aged 20-69 years. For the present cross-sectional study, 202 subjects (100 women and 102 men) were recruited. Twenty-four-hour urinary daidzein and its metabolites were determined in these subjects while on their usual diet and again after a 3-d isoflavone challenge. Fasting serum lipids, glucose and uric acid were examined on their usual diet. Three days of 24 h dietary recalls were used to assess dietary intakes. Of the 202 subjects, 27 (13.4 %) and 27 (13.4 %) excreted equol and O-DMA on their usual diet, and 101 (50 %) and 94 (46.5 %) produced equol and O-DMA after a load of 80 mg/d isoflavones. Equol producers showed lower serum uric acid ( - 10.2 %, P = 0.001), TAG ( - 29.5 %, P = 0.007) and waist:hip ratio ( - 2.6 %, P = 0.032), and tended to have higher HDL cholesterol (6.3 %, P = 0.069) compared with equol non-producers. There were no significant differences in serum lipids, glucose and uric acid between O-DMA producers and non-producers. In conclusion, equol phenotypes might influence cardiovascular risk.
authors.affiliation: Faculty of Nutrition, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Kaiping
authors.initials: K
authors.lastname: Guo
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Chaogang
authors.initials: C
authors.lastname: Chen
authors.forename: Shigeto
authors.initials: S
authors.lastname: Uchiyama
authors.forename: Tomomi
authors.initials: T
authors.lastname: Ueno
authors.forename: Yuming
authors.initials: Y
authors.lastname: Chen
authors.forename: Yixiang
authors.initials: Y
authors.lastname: Su
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002681:China; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D015930:Diet Records; D060754:Equol; D005260:Female; D006801:Humans; D007529:Isoflavones / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D048789:Phytoestrogens; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood*; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: C007610:4',7-dihydroxy-3,4-dihydroisoflavone; D008076:Cholesterol, HDL; D007529:Isoflavones; D008055:Lipids; D048789:Phytoestrogens; D014280:Triglycerides; D014527:Uric Acid; D060754:Equol; C004742:daidzein; C050052:O-desmethylangolensin