title: The strong relationship between bipolar and substance-use disorder.
abstract: Bipolar disorder and substance-use disorders commonly occur in the same individual. In fact, bipolar disorder has a higher prevalence of substance-use disorders than any other psychiatric illness. Individuals with both disorders have a more severe course of bipolar disorder, including earlier onset, more frequent episodes, and more complications, including anxiety- and stress-related disorders, aggressive behavior, legal problems, and suicide. Bipolar and substance-use disorders share common mechanisms, including impulsivity, poor modulation of motivation and responses to rewarding stimuli, and susceptibility to behavioral sensitization. Studies of potential treatments for bipolar substance-use disorder have paid scant attention to the combined disorders. The most promising treatment strategies are those that address their shared mechanisms.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, Texas, USA. alan.c.swann@uth.tmc.edu
authors.forename: Alan C
authors.initials: AC
authors.lastname: Swann
mesh_terms: D000342:Affective Symptoms / Q000150:complications; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000150:complications* / Q000209:etiology / Q000523:psychology / Q000628:therapy; D019970:Cocaine-Related Disorders / Q000150:complications / Q000209:etiology / Q000523:psychology / Q000628:therapy; D015928:Cognitive Behavioral Therapy; D003657:Decision Making; D006801:Humans; D007175:Impulsive Behavior / Q000150:complications; D008960:Models, Psychological; D019966:Substance-Related Disorders / Q000150:complications* / Q000209:etiology / Q000523:psychology / Q000628:therapy
chemical_list: D014150:Antipsychotic Agents