title: Sepsis-induced disseminated intravascular coagulation with features of thrombotic thrombocytopenic purpura: a fatal fulminant syndrome.
abstract: Disseminated intravascular coagulation (DIC) and thrombotic thrombocytopenic purpura (TTP) are different disease states, while ADAMTS13 deficiency could occur in sepsis-induced DIC. We report 2 patients who had septic DIC with features of idiopathic TTP characterized by low ADAMTS13 activity and positive ADAMTS13 inhibitor. They had a specific fulminant course and fatal outcome, which might represent a new specific syndrome.
authors.affiliation: Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China. zwang11@sina.com
authors.forename: Zhaoyue
authors.initials: Z
authors.lastname: Wang
authors.forename: Ziqiang
authors.initials: Z
authors.lastname: Yu
authors.forename: Jian
authors.initials: J
authors.lastname: Su
authors.forename: Lijuan
authors.initials: L
authors.lastname: Cao
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Zhao
authors.forename: Changgeng
authors.initials: C
authors.lastname: Ruan
mesh_terms: D051722:ADAM Proteins / Q000097:blood; D000071120:ADAMTS13 Protein; D000328:Adult; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D011480:Protease Inhibitors / Q000097:blood; D011697:Purpura, Thrombotic Thrombocytopenic / Q000097:blood / Q000209:etiology*; D018805:Sepsis / Q000097:blood / Q000150:complications*; D013577:Syndrome
chemical_list: D011480:Protease Inhibitors; D051722:ADAM Proteins; D000071120:ADAMTS13 Protein; C099604:ADAMTS13 protein, human