Cross-talk between transforming growth factor-beta and Wingless/Int pathways in lung development and disease.
Lung development depends on accurate and precise patterning of a pulmonary anlagen, consisting of both endodermally and mesodermally derived progenitor cells. In this process, the need to establish communication and control among individual cells is paramount. Transforming growth factor-beta (TGFbeta) and Wingless/int (Wnt) signaling pathways serve this need. The individual functional repertoire of the two pathways is further expanded by cross-talk and integration of signaling at multiple levels taking advantage of their hard-wired multi-component signal transduction platforms. Cross-talk creates the possibility for both specificity and versatility in signaling during development and during repair of injured tissue. Understanding the mechanics and the physiological implications of this cross-talk is necessary for therapeutic or preventive targeting of either TGFbeta or Wnt signaling pathways.
Minoo
Parviz
P
Division of Neonatology, Department of Pediatrics, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA. minoo@usc.edu
Li
Changgong
C
D000818:Animals; D002450:Cell Communication; D006801:Humans; D008168:Lung / Q000196:embryology / Q000502:physiology*; D038081:Organogenesis; D020239:Receptor Cross-Talk; D012038:Regeneration; D020545:Respiratory Mucosa / Q000196:embryology / Q000502:physiology*; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism*; D051153:Wnt Proteins / Q000378:metabolism*; D014945:Wound Healing
D016212:Transforming Growth Factor beta; D051153:Wnt Proteins