title: Rapid dissemination of newly introduced Plasmodium vivax genotypes in South Korea.
abstract: Reemerged Plasmodium vivax malaria in South Korea has not yet been eradicated despite continuous governmental efforts. It has rather become an endemic disease. Our study aimed to determine the genetic diversity in P. vivax merozoite surface protein-1 (PvMSP-1) and circumsporozoite protein (PvCSP) genes over an extended period after its reemergence to its current status. Sequence analysis of PvMSP-1 gene sequences from the 632 P. vivax isolates during 1996-2007 indicates that most isolates recently obtained were different from isolates obtained in the initial reemergence period. There was initially only one subtype (recombinant) present but its subtypes have varied since 2000; six MSP-1 subtypes were recently found. A similar variation was observed by CSP gene analysis; a new CSP subtype was found. Understanding genetic variation patterns of the parasite may help to analyze trends and assess extent of endemic malaria in South Korea.
authors.affiliation: Center for Immunology and Pathology, National Institute of Health, Korea Centers for Disease Control and Prevention, Seoul, Republic of Korea.
authors.forename: Yien-Kyoung
authors.initials: YK
authors.lastname: Choi
authors.forename: Kyung-Mi
authors.initials: KM
authors.lastname: Choi
authors.forename: Mi-Hyun
authors.initials: MH
authors.lastname: Park
authors.forename: Eun-Gyu
authors.initials: EG
authors.lastname: Lee
authors.forename: Yeon-Joo
authors.initials: YJ
authors.lastname: Kim
authors.forename: Byeong-Chul
authors.initials: BC
authors.lastname: Lee
authors.forename: Shin-Hyung
authors.initials: SH
authors.lastname: Cho
authors.forename: Ho-Gun
authors.initials: HG
authors.lastname: Rhie
authors.forename: Ho-Sa
authors.initials: HS
authors.lastname: Lee
authors.forename: Jae-Ran
authors.initials: JR
authors.lastname: Yu
authors.forename: Joo-Shil
authors.initials: JS
authors.lastname: Lee
authors.forename: Tong-Soo
authors.initials: TS
authors.lastname: Kim
authors.forename: Jung-Yeon
authors.initials: JY
authors.lastname: Kim
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D005838:Genotype; D006801:Humans; D015994:Incidence; D016780:Malaria, Vivax / Q000453:epidemiology* / Q000469:parasitology*; D020066:Merozoite Surface Protein 1 / Q000737:chemistry / Q000235:genetics; D008969:Molecular Sequence Data; D010966:Plasmodium vivax / Q000235:genetics*; D015995:Prevalence; D015800:Protozoan Proteins / Q000235:genetics; D056910:Republic of Korea / Q000453:epidemiology; D013997:Time Factors
chemical_list: D020066:Merozoite Surface Protein 1; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan