Is laminin gamma-1 a candidate gene for advanced pelvic organ prolapse?
OBJECTIVE
We sought to determine allele frequencies of 3 LAMC1 single nucleotide polymorphisms (SNPs) in Caucasian and African American (AA) women with stage>II pelvic organ prolapse (POP) (cases) and in ethnicity-matched controls with stage<II POP. We also sought to determine if LAMC1 is associated with POP within ethnic groups.


METHODS
Allelic discrimination was performed for LAMC1 SNPs rs10911193 (C/T), rs20563 (A/G), and rs20558 (T/C). SNP and haplotype-specific tests were used to examine associations among POP, ethnicity, and LAMC1.


RESULTS
In all, 411 women were enrolled. Significant differences in allele and haplotype frequencies existed among AAs and Caucasians: rs10911193 "T" (P=.0014); rs20563 "G" (P<.0001); rs20558 "C" (P<.0001); rs20563, rs20558 "GC" (P<.0001); and rs20563, rs20558 "AT" (P<.0001). No significant associations between POP and LAMC1 SNPs or haplotypes were found within ethnicities.


CONCLUSIONS
While significant differences were identified between AA and Caucasian women, no associations were found between any LAMC1 gene variant and advanced POP.
Chen
Chen
C
Department of Obstetrics and Gynecology, Virginia Commonwealth University Medical Center, Richmond, VA, USA.
Hill
Lori D
LD
Schubert
Christine M
CM
Strauss
Jerome F
JF
Matthews
Catherine A
CA
D001741:Black or African American / Q000235:genetics; D000368:Aged; D005260:Female; D056726:Genetic Association Studies; D006239:Haplotypes; D006801:Humans; D007797:Laminin / Q000235:genetics*; D015810:Linkage Disequilibrium; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D014596:Uterine Prolapse / Q000235:genetics* / Q000503:physiopathology; D044465:White People / Q000235:genetics
D007797:Laminin; C089141:laminin gamma 1