Placental vascular lesion differences in pregnancy-induced hypertension and normotensive fetal growth restriction.
OBJECTIVE
Pregnancy-induced hypertension/preeclampsia (PIH) and fetal growth restriction (FGR) share a common placental origin. The pathologic classification that divides placental lesions to maternal or fetal origin was compared between these disorders.


METHODS
Placentas from pregnancies that were complicated by PIH, normotensive FGR, or by both (combined) were analyzed, and lesions were classified as those consistent with maternal under-perfusion and with fetal thromboocclusive disease.


RESULTS
Maternal vascular lesions were more common in the PIH group and combined group (61% and 59%, respectively), compared with the FGR group (16.2%; P < .001), and villous lesions were more common in the combined group, compared with the FGR and PIH groups (79.5%, 53.5%, and 46.9%, respectively; P = .004). Fetal villous changes were observed in 16.2% in the FGR group, compared with 3.1% in the PIH group (P = .03), and chronic villitis was 15.2% in the FGR group vs 1.6% in the PIH group (P = .004).


CONCLUSIONS
Placental lesions correspond with different clinical presentations.
Kovo
Michal
M
Departments of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, Israel. michalkovo@gmail.com
Schreiber
Letizia
L
Ben-Haroush
Avi
A
Wand
Suzanna
S
Golan
Abraham
A
Bar
Jacob
J
D000328:Adult; D005260:Female; D005317:Fetal Growth Retardation / Q000473:pathology* / Q000503:physiopathology; D005865:Gestational Age; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000473:pathology* / Q000503:physiopathology; D008499:Medical Records; D018579:Patient Selection; D010920:Placenta / Q000098:blood supply* / Q000473:pathology* / Q000503:physiopathology; D011247:Pregnancy; D018709:Statistics, Nonparametric