Pd-catalyzed decarboxylative arylation of thiazole, benzoxazole, and polyfluorobenzene with substituted benzoic acids.
A Pd-catalyzed decarboxylative coupling of thiazoles and benzoxazole with various substituted benzoic acids is developed. The reaction is compatible with both electron-rich and electron-poor benzoic acids. It can also be extended to the synthesis of polyfluoro-substituted biaryls using polyfluorobenzenes as the starting materials.
Xie
Kai
K
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China.
Yang
Zhiyong
Z
Zhou
Xingjian
X
Li
Xiujian
X
Wang
Sizhuo
S
Tan
Ze
Z
An
Xiangyu
X
Guo
Can-Cheng
CC
D001565:Benzoates / Q000737:chemistry*; D001583:Benzoxazoles / Q000737:chemistry*; D002384:Catalysis; D003653:Decarboxylation; D005464:Fluorobenzenes / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism; D013844:Thiazoles / Q000737:chemistry*
D001565:Benzoates; D001583:Benzoxazoles; D005464:Fluorobenzenes; D013844:Thiazoles; D010165:Palladium