Obesity among HIV-infected persons: impact of weight on CD4 cell count.
To assess the effect of obesity on CD4 cell counts, we estimated the association of time-updated BMI categories with CD4 changes among 1001 documented HIV seroconverters. During the pre-highly active antiretroviral therapy (HAART) era, a higher BMI was associated with less reduction in CD4 cell counts over time. However during the HAART era, obese versus normal weight patients had smaller increases in CD4 cell counts (+69 versus +116 cells, P = 0.01). Lower CD4 cell counts may now be another adverse consequence of obesity.
Crum-Cianflone
Nancy F
NF
Infectious Disease Clinical Research Program, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Roediger
Mollie
M
Eberly
Lynn E
LE
Vyas
Kurt
K
Landrum
Mike L
ML
Ganesan
Anuradha
A
Weintrob
Amy C
AC
Barthel
Robert Vincent
RV
Agan
Brian K
BK
D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D001835:Body Weight / Q000276:immunology*; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008297:Male; D009765:Obesity / Q000276:immunology*; D019562:Viral Load