Interleukin-22 is a negative regulator of the allergic response.
A proinflammatory role of T helper (Th)17 cells, producing IL-22 and IL-17A, has been favored although there is evidence for negative immune regulation by IL-17A. Here we show that IL-22 was produced during an allergic response in lungs of mice, immunized and challenged with ovalbumin (OVA), and that IL-22 neutralization further augmented the eosinophil recruitment to the lung. In a second allergy model, transfer of OVA-pulsed dendritic cells (DC) into naive mice conveyed eosinophil recruitment in response to subsequent inhaled OVA challenge, while DC preincubation with recombinant IL-22 abolished this response. Similarly, DC preincubation with IL-17A abolished DC-driven eosinophil recruitment, showing that both Th17 cytokines IL-22 and IL-17A mediate negative regulation of allergy by acting on DCs. Therefore, IL-22 inhibits DC functions and attenuates an allergic response.
Schnyder
Bruno
B
Université d'Orléans and Centre National de la Recherche Scientifique, Molecular Immunology and Embryology (IEM), Orléans, France. Bruno.Schnyder@hevs.ch
Lima
Carla
C
Schnyder-Candrian
Silvia
S
D000818:Animals; D002465:Cell Movement; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology; D004804:Eosinophils / Q000166:cytology; D006967:Hypersensitivity / Q000276:immunology*; D015847:Interleukin-4 / Q000378:metabolism; D007378:Interleukins / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D008482:Mediastinum; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D015398:Signal Transduction; D018417:Th1 Cells / Q000166:cytology / Q000276:immunology; D018418:Th2 Cells / Q000166:cytology / Q000276:immunology; D000097043:Interleukin-22
D015847:Interleukin-4; D007378:Interleukins; D010047:Ovalbumin; D000097043:Interleukin-22