Rare influenza A (H3N2) variants with reduced sensitivity to antiviral drugs.
In 2007 and 2008 in Myanmar, we detected influenza viruses A (H3N2) that exhibited reduced sensitivity to both zanamivir and amantadine. These rare and naturally occurring viruses harbored a novel Q136K mutation in neuraminidase and S31N mutation in M2.
Dapat
Clyde
C
Department of Public Health, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan. clyde@med.niigata-u.ac.jp
Suzuki
Yasushi
Y
Saito
Reiko
R
Kyaw
Yadanar
Y
Myint
Yi Yi
YY
Lin
Nay
N
Oo
Htun Naing
HN
Oo
Khin Yi
KY
Win
Ne
N
Naito
Makoto
M
Hasegawa
Go
G
Dapat
Isolde C
IC
Zaraket
Hassan
H
Baranovich
Tatiana
T
Nishikawa
Makoto
M
Saito
Takehiko
T
Suzuki
Hiroshi
H
D000547:Amantadine / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral / Q000235:genetics; D006801:Humans; D053122:Influenza A Virus, H3N2 Subtype / Q000187:drug effects* / Q000235:genetics; D007251:Influenza, Human / Q000821:virology; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D009154:Mutation; D002052:Myanmar; D009439:Neuraminidase / Q000235:genetics; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D014763:Viral Matrix Proteins / Q000235:genetics*; D014764:Viral Proteins / Q000235:genetics; D053243:Zanamivir / Q000494:pharmacology*; D000086082:Viroporin Proteins
D000547:Amantadine; D000998:Antiviral Agents; D009439:Neuraminidase; D014763:Viral Matrix Proteins; D014764:Viral Proteins; D053243:Zanamivir; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins; C487630:NA protein, influenza A virus