The regulation and turnover of mitochondrial uncoupling proteins.
Uncoupling proteins (UCP1, UCP2 and UCP3) are important in regulating cellular fuel metabolism and as attenuators of reactive oxygen species production through strong or mild uncoupling. The generic function and broad tissue distribution of the uncoupling protein family means that they are increasingly implicated in a range of pathophysiological processes including obesity, insulin resistance and diabetes mellitus, neurodegeneration, cardiovascular disease, immunity and cancer. The significant recent progress describing the turnover of novel uncoupling proteins, as well as current views on the physiological roles and regulation of UCPs, is outlined.
Azzu
Vian
V
Medical Research Council Mitochondrial Biology Unit, Hills Road, Cambridge CB2 0XY, UK. va@mrc-mbu.cam.ac.uk
Jastroch
Martin
M
Divakaruni
Ajit S
AS
Brand
Martin D
MD
D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism; D004734:Energy Metabolism; D015870:Gene Expression; D006801:Humans; D007333:Insulin Resistance; D007473:Ion Channels / Q000235:genetics / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological; D009765:Obesity / Q000378:metabolism; D000071256:Uncoupling Protein 1; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3
D007473:Ion Channels; D024101:Mitochondrial Proteins; C000604371:UCP1 protein, human; C000604389:UCP2 protein, human; C000604392:UCP3 protein, human; D000071256:Uncoupling Protein 1; D000071246:Uncoupling Protein 2; D000071247:Uncoupling Protein 3