Overview of formation of G-quadruplex structures.
There are many structures that can be adopted by nucleic acids other than the Watson-Crick duplex. In particular, a noncanonical four-stranded topology, called a G-quadruplex, is of great interest because of its roles in key biological processes such as the maintenance of telomeres and regulation of gene transcription. This review describes the condition for forming the G-quadruplex structure, G-quadruplex-forming sequences, and methods for studying the structures.
Sannohe
Yuta
Y
Kyoto University, Kyoto, Japan.
Sugiyama
Hiroshi
H
D001483:Base Sequence; D054856:G-Quadruplexes; D009696:Nucleic Acids / Q000737:chemistry* / Q000235:genetics
D009696:Nucleic Acids