Serial measurement of the N-terminal pro-brain natriuretic peptide (NT-proBNP) predicts poor outcome in a patient with congenitally corrected transposition of the great arteries (ccTGA).
The usefulness of natriuretic peptides to assess myocardial function in patients with a systemic morphological right ventricle is still unclear. In this report we describe the clinical course of a young woman with congenitally corrected transposition of the great arteries (ccTGA) who suffered from a progressive deterioration of myocardial function after child birth despite intensive medical treatment and additional cardiac resynchronization therapy. In this woman, serial measurement of NT-proBNP levels was related to the velocity time integral over the aortic valve and indicated worsening of the patient's haemodynamic status and finally death.
Raedle-Hurst
Tanja M
TM
Department of Pediatric Cardiology, Saarland University Hospital, Kirrberger Str., D-66421 Homburg/Saar, Germany. tanja.raedle-hurst@uniklinikum-saarland.de
Hosse
Meryem
M
Abdul-Khaliq
Hashim
H
D000328:Adult; D015415:Biomarkers; D017147:Defibrillators, Implantable; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications; D011379:Prognosis; D014188:Transposition of Great Vessels / Q000000981:diagnostic imaging / Q000601:surgery*; D016896:Treatment Outcome; D014463:Ultrasonography
D015415:Biomarkers; D010446:Peptide Fragments; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain