title: Ultrastructural changes and immunolocalization of P-selectin in platelets from patients with major depression.
abstract: Depression is considered an important risk factor in patients with cardiovascular disease (CVD). Although the biological mechanism is unknown, it has been suggested that hyperactivity of platelets may have an important role in the onset and evolution of cardiovascular damage. The goals of this study were to evaluate by transmission electron microscopy and immunohistochemistry the presence of ultra-structural variations in platelets from individuals with recent diagnosis of major depression disease (MDD, patients without previous anti-depressant treatment and from healthy control subjects.). Platelets from depressed patients had a greater proportion of dendritic forms compared with those obtained from control subjects. Morphological changes, such as dilation of open canalicular and dense tubular systems, platelet vacuolization, electrodense pattern of membranes, and a different immunolocalization of P-selectin were observed in the platelets from depressed patients compared with those isolated from healthy subjects. Our results revealed ultra-structural changes in platelets isolated from patients with MDD suggestive of enhanced platelet activation.
authors.affiliation: Instituto Nacional de Psiquiatría "Ramón de la Fuente", México City, México.
authors.forename: José
authors.initials: J
authors.lastname: Mendoza-Sotelo
authors.forename: Carlos
authors.initials: C
authors.lastname: Torner
authors.forename: Noé
authors.initials: N
authors.lastname: Alvarado-Vásquez
authors.forename: Alejandro
authors.initials: A
authors.lastname: Lazo-Langner
authors.forename: Guadalupe
authors.initials: G
authors.lastname: López
authors.forename: Iván
authors.initials: I
authors.lastname: Arango
authors.forename: Lenin
authors.initials: L
authors.lastname: Pavón
authors.forename: Eva
authors.initials: E
authors.lastname: González-Trujano
authors.forename: Julia
authors.initials: J
authors.lastname: Moreno
mesh_terms: D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000378:metabolism* / Q000648:ultrastructure*; D003865:Major Depressive Disorder / Q000097:blood / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission / Q000379:methods; D008875:Middle Aged; D019007:P-Selectin / Q000378:metabolism*; D055815:Young Adult
chemical_list: D019007:P-Selectin