title: L-Histidine and L-arginine promote Knoevenagel reaction in water.
abstract: Histidine and arginine were applied to the synthesis of trisubstituted alkenes through a condensation of an aldehyde with an activated CH-acid such as ethyl cyanoacetate, malononitrile, acetyl acetone or ethyl acetoacetate during 5-12 h in water at room temperature.
authors.affiliation: Department of Chemistry, University of Isfahan, P. O. Box 81746-73441, Isfahan, Iran. a.rahmati@sci.ui.ac.ir
authors.forename: Abbas
authors.initials: A
authors.lastname: Rahmati
authors.forename: Kobra
authors.initials: K
authors.lastname: Vakili
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry; D001120:Arginine / Q000737:chemistry*; D055598:Chemical Phenomena; D006639:Histidine / Q000737:chemistry*; D008956:Models, Chemical; D014867:Water / Q000737:chemistry
chemical_list: D000447:Aldehydes; D000475:Alkenes; D014867:Water; D006639:Histidine; D001120:Arginine