[The synergistic and toxicity-reducing effects of zhenqifuzheng injection on mice with 60Co radiotherapy].
OBJECTIVE
To study the synergistic and toxicity-reducing effect of zhenqifuzheng (ZQFZ) injection on mice with 60Co radiotherapy.


METHODS
The tumor-bearing mice models with Hepatoma-22 were established. Mice in 60Co control group were treated by 60Co; ZQFZ injection were administered with dosages of 1.5, 3.0, 6.0 g/(kg x d) through ip for 7 days,then the inhibitory rate, the number of WBC,the spleen and thymus index were calculated. Meanwhile,the MDA content and SOD activity in serum were determined. Phagocytosis of mononuclear macrophage was determined with carbon particle clearance test.


RESULTS
Each dose of ZQFZ injection inhibited the development of tumor, and had synergism with 60Co. High dose of ZQFZ injection increased the number of WBC, and the spleen index in all ZQFZ groups increased (P < 0.05 or P < 0.01). Whereas, no significant difference was found of thymus index in all groups, and the changes of MDA content and SOD activity induced by 60Co were reversed obviously by three doses of ZQFZ (P < 0.05 or P < 0.01). Meanwhile, non-specific immunity was enhanced in different degree in three doses of ZQFZ groups (P < 0.01).


CONCLUSIONS
ZQFZ injection can increase the activity of non-specific immunity, improve the anti-tumor effects and meanwhile attenuate the toxicity of 60Co, which may be related to the antagonistic effect on lipid peroxidation.
Liu
Huan-long
HL
Department of Pharmacology, Hebei Medical University, Shijiazhuang 050017, China. lhlong0904@163.com
Chen
Xue-yan
XY
Pan
Zhen-hua
ZH
Zhang
Yong-jian
YJ
D000818:Animals; D027885:Astragalus propinquus / Q000737:chemistry; D003037:Cobalt Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007274:Injections, Intraperitoneal; D007962:Leukocytes; D031659:Ligustrum / Q000737:chemistry; D008114:Liver Neoplasms, Experimental / Q000628:therapy*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D010587:Phagocytosis / Q000187:drug effects; D008517:Phytotherapy; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage / Q000494:pharmacology*; D011879:Radiotherapy Dosage; D013154:Spleen / Q000187:drug effects
D003037:Cobalt Radioisotopes; D004365:Drugs, Chinese Herbal; D011838:Radiation-Sensitizing Agents