Common genetic variation in MTNR1B is associated with serum testosterone, glucose tolerance, and insulin secretion in polycystic ovary syndrome patients.
Melatonin plays an important role in many aspects of the human reproductive process. Our results first strongly suggest that MTNR1B mediating some functions of melatonin contributes to the phenotypic expression of polycystic ovary syndrome, which provide a new insight into the role of MTNR1B gene in the pathophysiology of the disease.
Wang
Lei
L
Institutes of Biomedical Science, Fudan University, Shanghai, People's Republic of China. wangleiwanglei@fudan.edu.cn
Wang
Ying
Y
Zhang
Xiaoping
X
Shi
Juanzi
J
Wang
Min
M
Wei
Zhiyun
Z
Zhao
Aman
A
Li
Baojie
B
Zhao
Xinzhi
X
Xing
Qinghe
Q
He
Lin
L
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005947:Glucose / Q000378:metabolism*; D018149:Glucose Intolerance / Q000150:complications / Q000235:genetics; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide; D044123:Receptor, Melatonin, MT2 / Q000235:genetics*; D013739:Testosterone / Q000097:blood*
D007328:Insulin; D044123:Receptor, Melatonin, MT2; D013739:Testosterone; D005947:Glucose