A receptor-grounded approach to teaching nonsteroidal antiinflammatory drug chemistry and structure-activity relationships.
OBJECTIVE
To describe a receptor-based approach to promote learning about nonsteroidal anti-inflammatory drug (NSAID) chemistry, structure-activity relationships, and therapeutic decision-making.


METHODS
Three lessons on cyclooxygenase (COX) and NSAID chemistry, and NSAID therapeutic utility, were developed using text-based resources and primary medicinal chemistry and pharmacy practice literature. Learning tools were developed to assist students in content mastery.


RESULTS
Student learning was evaluated via performance on quizzes and examinations that measured understanding of COX and NSAID chemistry, and the application of that knowledge to therapeutic problem solving.


CONCLUSIONS
Student performance on NSAID-focused quizzes and examinations documented the success of this approach.
Roche
Victoria F
VF
School of Pharmacy and Health Professions, Creighton University Medical Center, Omaha, NE 68178, USA. roche@creighton.edu
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D001665:Binding Sites; D002626:Chemistry, Pharmaceutical / Q000193:education*; D002983:Clinical Competence; D032882:Comprehension; D051545:Cyclooxygenase 1 / Q000737:chemistry* / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000737:chemistry* / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D004512:Education, Pharmacy / Q000379:methods*; D004521:Educational Measurement; D006801:Humans; D008958:Models, Molecular; D015394:Molecular Structure; D018794:Problem-Based Learning; D016730:Program Development; D015397:Program Evaluation; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013663:Teaching / Q000379:methods*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2