[CDX2--an immunochystochemistry marker of intestinal differentiation of adenocarcinomas].
CDX2 is a nuclear transcribing factor, important for the development and differentiation of the bowels. According to the recent publications, CDX2 expression is immunochystochemisry detector in the normal enterocytes of the bowels and is normally met in the most, but not at all colorectal carcinomas. Two homeostatic genes are detected at people CDX1 u CDX2. We present examination of CDX2 expression at 15 adenomas and 30 colorectal carcinomas. All the adenomas are positive for CDX2, 27 /90%/ of the adenocarcinomas show nuclear expression of CDX2.
Porjazova
E
E
Zaprjanov
Z
Z
Milchev
N
N
Markova
D
D
Batashki
I
I
D000230:Adenocarcinoma / Q000235:genetics*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D007422:Intestines / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D014408:Biomarkers, Tumor; C491273:CDX1 protein, human; D018398:Homeodomain Proteins