Oxidative stress status in renal transplant recipients.
OBJECTIVE
Despite the demonstration of oxidative stress in patients with end-stage renal disease, the oxidative status during and after a renal transplant are not completely understood. Hepatocyte growth factor is reported to act as an endogenous factor against oxidative stress. The aim of this study was to evaluate the pattern of changes in plasma oxidative status and hepatocyte growth factor levels in living-donor renal transplant recipients during the early phase after transplant.


METHODS
Nineteen patients who underwent a renal transplant were included. All were on cyclosporine-based immunosuppression. Plasma levels of malondialdehyde, ferric reducing activity, hepatocyte growth factor, vitamin E, erythrocyte glutathione, and superoxide dismutase activities were determined before, and on the second, seventh, and 12th days after the transplant.


RESULTS
High malondialdehyde concentration and low superoxide dismutase activity were seen before and 48 hours after transplant compared with healthy subjects. Significant reductions in plasma ferric reducing activity, malondialdehyde, and hepatocyte growth factor were seen on the seventh and twelfth days after transplant, compared with the before-transplant data. Direct correlations were found between hepatocyte growth factor levels and ferric reducing activity of plasma as well as hepatocyte growth factor and creatinine or uric acid.


CONCLUSIONS
Renal transplant recipients display persistent oxidative stress during the early phase of transplant. The pattern of oxidative changes should be considered for appropriate time, dosage, type, and the duration of antioxidant therapy in these patients.
Zahmatkesh
Maryam
M
Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. zahmatkm@tums.ac.ir
Kadkhodaee
Mehri
M
Mahdavi-Mazdeh
Mitra
M
Ghaznavi
Rana
R
Hemati
Mohamad
M
Seifi
Behjat
B
Golab
Fereshteh
F
Hasani
Keyvan
K
Lessan-Pezeshki
Mahbob
M
Einollahi
Behzad
B
D000328:Adult; D005260:Female; D005978:Glutathione / Q000097:blood; D017228:Hepatocyte Growth Factor / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery*; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D012189:Retrospective Studies; D013482:Superoxide Dismutase / Q000097:blood; D014810:Vitamin E / Q000097:blood
D017382:Reactive Oxygen Species; D014810:Vitamin E; D008315:Malondialdehyde; D017228:Hepatocyte Growth Factor; D013482:Superoxide Dismutase; D005978:Glutathione