Approaches for imaging islets: recent advances and future prospects.
The establishment of improved technologies for imaging of the pancreas is a key element in addressing several aspects of diabetes pathogenesis. In this respect, the development of a protocol that allows for non-invasive scoring of human islets, or islet beta-cells, is of particular importance. The development of such a technology would have profound impact on both clinical and experimental medicine, ranging from early diagnosis of diabetes to the evaluation of therapeutic regimes. Another important task is the development of modalities for high-resolution imaging of experimental animal models for diabetes. Rodent models for diabetes research have for decades been instrumental to the diabetes research community. The ability to image, and to accurately quantify, key players of diabetogenic processes with molecular specificity will be of great importance for elucidating mechanistic aspects of the disease. This chapter aims to overview current progress within these research areas.
Ahlgren
Ulf
U
Umeå Centre for Molecular Medicine, Umeå University, S-901 87 Umeå, Sweden. ulf.ahlgren@ucmm.umu.se
Gotthardt
Martin
M
D000818:Animals; D003920:Diabetes Mellitus / Q000473:pathology*; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D050417:Insulin-Secreting Cells / Q000166:cytology; D007515:Islets of Langerhans / Q000502:physiology*; D049449:Luminescence; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008954:Models, Biological; D055095:Optics and Photonics / Q000379:methods; D010179:Pancreas / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D041622:Tomography, Optical / Q000379:methods