title: Copper-mediated N-heteroarylation of primary sulfonamides: synthesis of mono-N-heteroaryl sulfonamides.
abstract: We describe the coupling of primary sulfonamides and various halogenated heterocyclic cores, with an emphasis on 2-heteroaryl halides, via copper catalysis. These studies enabled the synthesis of many new mono-N-heteroaryl sulfonamides. The electronic factors that influence the course of the reaction have also been investigated.
authors.affiliation: Novartis Institutes for Biomedical Research, Inc. Oncology, Global Discovery Chemistry, 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Baffoe
authors.forename: Madelene Y
authors.initials: MY
authors.lastname: Hoe
authors.forename: B Barry
authors.initials: BB
authors.lastname: Touré
mesh_terms: D003300:Copper / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D007454:Iodides; D013449:Sulfonamides; D003300:Copper; C073870:cuprous iodide