Transition-metal-free electrophilic amination between aryl Grignard reagents and N-chloroamines.
In the presence of N,N,N',N'-tetramethylethylenediamine (TMEDA) as an additive, easily prepared and handled N-chloroamines react with aryl Grignard reagents to give a variety of arylamines in good to excellent yields. Functional groups such as ester and nitrile are compatible under the reaction conditions.
Hatakeyama
Takuji
T
International Research Center for Elements Science, Institute for Chemical Research, Kyoto University, Uji, Kyoto, 611-0011, Japan.
Yoshimoto
Yuya
Y
Ghorai
Sujit K
SK
Nakamura
Masaharu
M
D000586:Amination; D002700:Chloramines / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
D002700:Chloramines; D009942:Organometallic Compounds; C450681:phenyllithium