YMDD mutation in Pakistani patients. The comparison of Eastern response with the Western response.
Lamivudine exhibits potent antiviral activity in chronic hepatitis B. YMDD mutations in west is around 32% (5 years) but reports from East are scarce. To evaluate frequency of lamivudine resistance and compare the results with the West, a total of 100 chronic hepatitis B patients were given Lamivudine 100 mg before breakfast. Out of 81 patients (19 no follow up), (85%) males and (15%) females. Wild type were 69 (85%) and 12 (14.8%) pre-core mutants. At 1 year 25/69 wild type (36.2%) lost their HBeAg and 18 (26%) seroconverted. At 2 years 30 (43.4%) became HBeAg negative and 22(31.8%) had positive anti-HBe. At 3 years 33 (47.8%) became HBeAg negative and 25 (36.2%) sero-converted. Of 12 precore mutants 8 (66.6%) lost HBV DNA within 24 weeks of therapy. At 36 months 44.4% showed sero-conversion with a YMDD mutation rate of 6% which is in contrast to 32% reported from the West.
Qureshi
Huma
H
Pakistan Medical Research Center, Jinnah Postgraduate Medical Center, Karachi, Pakistan.
Arif
Ambreen
A
Ahmed
Waquaruddin
W
Alam
Syed Ejaz
SE
D000998:Antiviral Agents / Q000494:pharmacology / Q000627:therapeutic use; D004259:DNA-Directed DNA Polymerase / Q000235:genetics; D005260:Female; D006515:Hepatitis B virus / Q000235:genetics; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000235:genetics*; D006801:Humans; D019259:Lamivudine / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D010154:Pakistan; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D019259:Lamivudine; D004259:DNA-Directed DNA Polymerase