title: Epistatic interactions.
abstract: The term "epistasis" is sometimes used to describe some form of statistical interaction between genetic factors and is alternatively sometimes used to describe instances in which the effect of a particular genetic variant is masked by a variant at another locus. In general statistical tests for interaction are of limited use in detecting "epistasis" in the sense of masking. It is, however, shown that there are relations between empirical data patterns and epistasis that have not been previously noted. These relations can sometimes be exploited to empirically test for "epistatic interactions" in the sense of the masking of the effect of a particular genetic variant by a variant at another locus.
authors.affiliation: Harvard University, USA. tvanderw@hsph.harvard.edu
authors.forename: Tyler J
authors.initials: TJ
authors.lastname: VanderWeele
mesh_terms: D056808:Biostatistics; D016022:Case-Control Studies; D004843:Epistasis, Genetic; D056726:Genetic Association Studies; D006801:Humans; D016015:Logistic Models; D008957:Models, Genetic; D015233:Models, Statistical