The FOX(O1) blasts off.
Systemic glucose homeostasis is primarily regulated by insulin, which targets liver, fat, and skeletal muscle cells, setting up important feedback loops. New studies now show that the osteoblast also has a significant role in modulating systemic insulin responses, via the insulin-regulated transcription factor FOXO1 and the hormone osteocalcin.
Novack
Deborah Veis
DV
Washington University School of Medicine, 660 S. Euclid Avenue, Box 8301, St. Louis, MO 63110, USA.