title: Haematological, biochemical and histopathological alterations induced by abamectin and Bacillus thuringiensis in male albino rats.
abstract: The renal- and hepato-toxicity induced by abamectin pesticide (Vertimec) and a commercial form of a bio-insecticide Bacillus thuringiensis (Agerin) in male albino rats were evaluated. Blood picture and blood glucose level were investigated. Male albino rats were administered dietary doses each equivalent to 1/10 or 1/100 of the LD50 values of each toxicant for 30 consecutive days. Abamectin was found to pose risks of renal- and hepato-toxicity in rats, since the biochemical parameters of liver function (i.e. aspartate aminotransferase activity, alanine aminotransferase activity, acid phosphatase activity, albumin, and total protein levels) and kidney function (uric acid and creatinine concentration) were severely affected. These effects were verified by histopathological examination of liver and kidney tissues. Likewise, some haematological indices (i.e. erythrocyte count, leukocyte count and haemoglobin concentration) were also influenced; in addition abamectin might cause hypoglycaemia. On the other hand, the above-mentioned lesions were less pronounced in the case of Bacillus thuringiensis -treated rats.
authors.affiliation: Environment and Bio-agriculture Department, Faculty of Agriculture, Al-Azhar University, 11884, Cairo, Egypt. fawzy.eissa@yahoo.com
authors.forename: F I
authors.initials: FI
authors.lastname: Eissa
authors.forename: N A
authors.initials: NA
authors.lastname: Zidan
mesh_terms: D000818:Animals; D001413:Bacillus thuringiensis / Q000378:metabolism*; D004032:Diet; D006403:Hematologic Tests; D007306:Insecticides / Q000494:pharmacology*; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000494:pharmacology; D007668:Kidney / Q000166:cytology / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007928:Lethal Dose 50; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D011897:Random Allocation; D051381:Rats / Q000033:anatomy & histology / Q000382:microbiology*; D017207:Rats, Sprague-Dawley
chemical_list: D007306:Insecticides; C048324:abamectin; D007559:Ivermectin