title: Complexity in influenza virus targeted drug design: interaction with human sialidases.
abstract: With the global spread of the pandemic H1N1 and the ongoing pandemic potential of the H5N1 subtype, the influenza virus represents one of the most alarming viruses spreading worldwide. The influenza virus sialidase is an effective drug target, and a number of inhibitors are clinically effective against the virus (zanamivir, oseltamivir, peramivir). Here we report structural and biochemical studies of the human cytosolic sialidase Neu2 with influenza virus sialidase-targeting drugs and related compounds.
authors.affiliation: PF-IMSS-KEK-SBRC, Ibaraki 305-0801, Japan.
authors.forename: Leonard M G
authors.initials: LM
authors.lastname: Chavas
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kato
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Suzuki
authors.forename: Mark
authors.initials: M
authors.lastname: von Itzstein
authors.forename: Maretta C
authors.initials: MC
authors.lastname: Mann
authors.forename: Robin J
authors.initials: RJ
authors.lastname: Thomson
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Dyason
authors.forename: Jennifer
authors.initials: J
authors.lastname: McKimm-Breschkin
authors.forename: Paola
authors.initials: P
authors.lastname: Fusi
authors.forename: Cristina
authors.initials: C
authors.lastname: Tringali
authors.forename: Bruno
authors.initials: B
authors.lastname: Venerando
authors.forename: Guido
authors.initials: G
authors.lastname: Tettamanti
authors.forename: Eugenio
authors.initials: E
authors.lastname: Monti
authors.forename: Soichi
authors.initials: S
authors.lastname: Wakatsuki
mesh_terms: D018360:Crystallography, X-Ray; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000201:enzymology; D053124:Influenza A Virus, H5N1 Subtype / Q000201:enzymology; D008958:Models, Molecular; D008968:Molecular Conformation; D009439:Neuraminidase / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D009975:Orthomyxoviridae / Q000201:enzymology*
chemical_list: D004791:Enzyme Inhibitors; C403285:NEU2 protein, human; D009439:Neuraminidase