title: Combining enteral with parenteral nutrition to improve postoperative glucose control.
abstract: The provision of parenteral nutrition (PN) to 'stressed' patients often results in hyperglycaemia, which may be detrimental. In animal models limited amounts of enteral nutrition (EN) improve intestinal integrity and stimulate intestinal incretin production, which may lead to improved glucose control. We set out to assess if combining EN with PN results in improved glucose homeostasis rather than PN given alone. We conducted a randomised trial in a university teaching hospital of patients undergoing a 'curative' oesophagectomy for adenocarcinoma. Differences between the two intervention groups were assessed for continuous glucose measurement, insulin sensitivity using insulin tolerance tests (ITT) and homeostasis model analysis (HOMA), the incretin glucose-dependent insulinotropic polypeptide (GIP) and intestinal permeability. The combination of PN with EN resulted in lower interstitial glucose concentrations (P = 0.002), reduced insulin resistance, improved insulin sensitivity (HOMA-insulin resistance (IR) P = 0.045; HOMA beta P = 0.037; ITT P = 0.006), improved intestinal permeability (P < 0.001) and increased GIP (P = 0.01) when compared with PN alone. The combination of EN with PN, when compared with PN alone, results in reduced glucose concentrations, reduced insulin resistance, increased incretins and improvements in intestinal permeability.
authors.affiliation: Department of Surgery, Derriford Hospital, Plymouth, UK.
authors.forename: Paul
authors.initials: P
authors.lastname: Lidder
authors.forename: Daniel
authors.initials: D
authors.lastname: Flanagan
authors.forename: Simon
authors.initials: S
authors.lastname: Fleming
authors.forename: Mark
authors.initials: M
authors.lastname: Russell
authors.forename: Noel
authors.initials: N
authors.lastname: Morgan
authors.forename: Tim
authors.initials: T
authors.lastname: Wheatley
authors.forename: Jo
authors.initials: J
authors.lastname: Rahamin
authors.forename: Steve
authors.initials: S
authors.lastname: Shaw
authors.forename: Stephen
authors.initials: S
authors.lastname: Lewis
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery; D000368:Aged; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D004750:Enteral Nutrition / Q000379:methods*; D004938:Esophageal Neoplasms / Q000601:surgery; D016629:Esophagectomy; D005260:Female; D006706:Homeostasis; D006801:Humans; D054795:Incretins / Q000032:analysis / Q000378:metabolism; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition / Q000379:methods*; D011182:Postoperative Care / Q000379:methods*
chemical_list: D001786:Blood Glucose; D054795:Incretins; D007328:Insulin