title: [Antimicrobial susceptibility patterns of Legionella isolates in the environment and in patients].
abstract: BACKGROUND
  Antimicrobial susceptibility of Legionella spp. has rarely been studied in Korea. Therefore, we aimed to determine the susceptibility of Legionella spp. to various antibiotics.
  
  
  METHODS
  We assessed the antimicrobial susceptibility of 66 environmental and clinical Legionella isolates collected between January 2001 and December 2008 from Korea and Japan. The minimum inhibitory concentrations (MICs) of 6 antibiotics, namely, azithromycin, ciprofloxacin, clarithromycin, clindamycin, gatifloxacin, and gemifloxacin were determined by the broth microdilution method using buffered starch yeast extract broth.
  
  
  RESULTS
  The MIC ranges of the 6 antibiotics used against the Legionella isolates were as follows: 0.004-0.062 microg/mL (azithromycin), 0.002-0.5 microg/mL (ciprofloxacin), 0.004-0.5 microg/mL (clarithromycin), 0.12-4 microg/mL (clindamycin), 0.002-0.12 microg/mL (gatifloxacin), and 0.008-1 microg/mL (gemifloxacin).
  
  
  CONCLUSIONS
  Legionella spp. isolates from Korea and Japan were most susceptible to gatifloxacin. Azithromycin, clarithromycin, ciprofloxacin, and gemifloxacin were also effective for treating legionellosis.
authors.affiliation: Department of Laboratory Medicine, Pusan National University School of Medicine, Busan, Korea.
authors.forename: Go Eun
authors.initials: GE
authors.lastname: Choi
authors.forename: Jeong Eun
authors.initials: JE
authors.lastname: Kang
authors.forename: Eun Yup
authors.initials: EY
authors.lastname: Lee
authors.forename: Chulhun L
authors.initials: CL
authors.lastname: Chang
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tateda
authors.forename: Keizo
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Kyeong Hee
authors.initials: KH
authors.lastname: Kim
authors.forename: Jeong Man
authors.initials: JM
authors.lastname: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D017291:Clarithromycin / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D024881:Drug Resistance, Bacterial; D024841:Fluoroquinolones / Q000494:pharmacology; D000077734:Gatifloxacin; D000077735:Gemifloxacin; D006801:Humans; D007875:Legionella / Q000187:drug effects* / Q000302:isolation & purification; D007876:Legionellosis / Q000175:diagnosis / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D002981:Clindamycin; D002939:Ciprofloxacin; D017963:Azithromycin; D017291:Clarithromycin; D000077734:Gatifloxacin; D000077735:Gemifloxacin