title: Impact of tube current in the quantitative assessment of acute reperfused myocardial infarction with 64-slice delayed-enhancement CT: a porcine model.
abstract: OBJECTIVE
  This study evaluated the impact of tube current (mAs) in delayed-enhancement computed tomography (CT) imaging for assessing acute reperfused myocardial infarction in a porcine model.
  
  
  METHODS
  In five domestic pigs (mean weight 24 kg), the circumflex coronary artery was balloon-occluded for 2 h and then reperfused. After 5 days, CT imaging was performed following administration of iodinated contrast material. A 64-slice CT system was used to perform first-pass coronary angiography with a tube current of 15 mAs/kg [Arterial Phase (ART)] followed by two delayed-enhancement (DE) scans 15 min after contrast material administration, with a tube current of 15 mAs/kg and 37.5 mAs/kg, respectively (DE(1) and DE(2)). The mean heart rate decreased to 51±9 beats/min after administration of zatebradine (10 mg/kg IV). The data set was reconstructed during the end-diastolic phase of the cardiac cycle. Areas with DE, no reflow and remote myocardium [remote left ventricular (LV)] were calculated. CT values expressed in Hounsfield units (HU) were measured using five regions of interest (ROI): DE, no reflow, remote LV, LV cavity (LV lumen) and in air, respectively. Differences, correlations, image quality [signal-to-noise ratio (SNR)] and contrast resolution [contrast-to-noise ratio (CNR)] were calculated.
  
  
  RESULTS
  Significant differences were found between attenuation of areas of DE, no reflow and remote LV (p<0.001) within the different scans. There was a fair correlation between DE and no-reflow attenuation (r=0.6; p<0.001). In DE(1) vs. DE(2), areas of DE and no reflow were not significantly different (p>0.05). The SNR and CNR were not significantly different in DE(1) vs. DE(2) (p>0.05).
  
  
  CONCLUSIONS
  Tube current does not significantly affect infarction area, image quality or contrast resolution of DE imaging with CT.
authors.affiliation: Department of Radiology and Cardiology, Academic Hospital/Azienda Ospedaliero-Universitaria, Parma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Martini
authors.forename: E
authors.initials: E
authors.lastname: Maffei
authors.forename: A
authors.initials: A
authors.lastname: Palumbo
authors.forename: A
authors.initials: A
authors.lastname: Weustink
authors.forename: T
authors.initials: T
authors.lastname: Baks
authors.forename: A
authors.initials: A
authors.lastname: Moelker
authors.forename: D
authors.initials: D
authors.lastname: Dunker
authors.forename: A
authors.initials: A
authors.lastname: Cuttone
authors.forename: E
authors.initials: E
authors.lastname: Emiliano
authors.forename: N
authors.initials: N
authors.lastname: Mollet
authors.forename: G
authors.initials: G
authors.lastname: Krestin
authors.forename: P
authors.initials: P
authors.lastname: De Feyter
authors.forename: F
authors.initials: F
authors.lastname: Cademartiri
mesh_terms: D000818:Animals; D003287:Contrast Media; D017023:Coronary Angiography; D003326:Coronary Circulation; D006321:Heart / Q000000981:diagnostic imaging*; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000628:therapy; D015425:Myocardial Reperfusion; D034421:Sus scrofa; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D003287:Contrast Media