title: Asparaginase-related venous thrombosis in UKALL 2003- re-exposure to asparaginase is feasible and safe.
abstract: We report the incidence and outcome of venous thrombosis (VT) in the UK acute lymphoblastic leukaemia (ALL) 2003 trial. VT occurred in 59/1824 (3.2%) patients recruited over 5 years with 90% occurring during a period of Asparagine depletion. Pegylated Escherichia Coli Asparaginase (Peg-ASP) 1000 units/m(2) was used throughout. Thirty-four children received further Peg-ASP, most with concurrent heparin prophylaxis. There were no episodes of bleeding or recurrent thrombosis. Optimal Asparagine depletion is central to success of modern regimes for treatment of ALL. This report confirms a significant risk of thrombosis with such therapy, but demonstrates that re-exposure to Asparaginase is feasible and safe.
authors.affiliation: Department of Haematology, Children's Hospital, The John Radcliffe, Oxford, UK. amrana.qureshi@orh.nhs.uk
authors.forename: Amrana
authors.initials: A
authors.lastname: Qureshi
authors.forename: Chris
authors.initials: C
authors.lastname: Mitchell
authors.forename: Sue
authors.initials: S
authors.lastname: Richards
authors.forename: Ajay
authors.initials: A
authors.lastname: Vora
authors.forename: Nick
authors.initials: N
authors.lastname: Goulden
mesh_terms: D000293:Adolescent; D000925:Anticoagulants / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001215:Asparaginase / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005240:Feasibility Studies; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy; D011446:Prospective Studies; D020246:Venous Thrombosis / Q000139:chemically induced* / Q000517:prevention & control
chemical_list: D000925:Anticoagulants; D000970:Antineoplastic Agents; D006495:Heparin, Low-Molecular-Weight; D001215:Asparaginase