title: Two distinct clonal populations in acute promyelocytic leukemia, one involving chromosome 17 and the other involving an isochromosome 17.
abstract: Acute promyelocytic leukemia (APL) is characterized by a t(15;17)(q22;q21) rearrangement. Additional chromosomal rearrangements have been reported in 25-40% of APL patients. The most common abnormality involving chromosome 17 is ider(17). Here we report the case of a patient with APL with isochromosome 17q combined with ider(17), confirmed by fluorescence in situ hybridization. Cytogenetic data strongly suggest that the involvement of chromosomes 15 and 17 in translocation occurs after formation of the isochromosome 17. The case reported here presents the novel finding of two separate clonal events apparently occurring at the same time in an APL patient.
authors.affiliation: Department of Laboratory Medicine, College of Medicine, The Catholic University of Korea, Seoul St. Mary's Hospital, 505 Banpo-dong, Seocho-gu, Seoul, Korea.
authors.forename: Myungshin
authors.initials: M
authors.lastname: Kim
authors.forename: Sun Ah
authors.initials: SA
authors.lastname: Lee
authors.forename: Hae-il
authors.initials: HI
authors.lastname: Park
authors.forename: Eun-Jee
authors.initials: EJ
authors.lastname: Oh
authors.forename: Chong Won
authors.initials: CW
authors.lastname: Park
authors.forename: Jihyang
authors.initials: J
authors.lastname: Lim
authors.forename: Kyungja
authors.initials: K
authors.lastname: Han
authors.forename: Yonggoo
authors.initials: Y
authors.lastname: Kim
mesh_terms: D000368:Aged; D002886:Chromosomes, Human, Pair 17; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D018404:Isochromosomes; D007621:Karyotyping; D015473:Leukemia, Promyelocytic, Acute / Q000235:genetics* / Q000473:pathology