title: Image fusion of coronary CT angiography and cardiac perfusion MRI: a pilot study.
abstract: OBJECTIVE
  To develop a tool for the image fusion of computed tomography coronary angiography (CTCA) and cardiac magnetic resonance imaging (CMR).
  
  
  METHODS
  Surface representations and volume-rendered images from fused CTCA/CMR data of five patients with significant coronary artery disease (CAD) on CTCA and perfusion deficits on CMR were generated using a newly developed software prototype. The spatial relationship of significant coronary artery stenosis at CTCA and myocardial defects at CMR was evaluated.
  
  
  RESULTS
  Registration of CTCA and CMR images was possible in all patients. The comprehensive three-dimensional visualisation of fused CTCA and CMR data accurately demonstrated the relationship between coronary artery stenoses and myocardial defects in all patients.
  
  
  CONCLUSIONS
  The introduced tool enables image fusion of CTCA and CMR data sets and allows for correct superposition of the coronary arteries derived from CTCA onto the corresponding myocardial segments derived from CMR. The method facilitates the comprehensive assessment of the functionally relevant CAD by the exact allocation of culprit coronary stenoses to corresponding myocardial defects at a low radiation dose.
authors.affiliation: Institute of Diagnostic Radiology, University Hospital Zurich, Zurich, Switzerland.
authors.forename: Paul
authors.initials: P
authors.lastname: Stolzmann
authors.forename: Hatem
authors.initials: H
authors.lastname: Alkadhi
authors.forename: Hans
authors.initials: H
authors.lastname: Scheffel
authors.forename: Anja
authors.initials: A
authors.lastname: Hennemuth
authors.forename: Caroline
authors.initials: C
authors.lastname: Kuehnel
authors.forename: Stephan
authors.initials: S
authors.lastname: Baumueller
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kozerke
authors.forename: Volkmar
authors.initials: V
authors.lastname: Falk
authors.forename: Borut
authors.initials: B
authors.lastname: Marincek
authors.forename: Olivio F
authors.initials: OF
authors.lastname: Donati
mesh_terms: D000368:Aged; D000465:Algorithms; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D003287:Contrast Media; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional; D007472:Iohexol / Q000031:analogs & derivatives; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012984:Software; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media; D007472:Iohexol; C038192:iopromide