title: Human mitochondrial mRNAs--like members of all families, similar but different.
abstract: The messenger RNAs containing the thirteen protein coding sequences of the human mitochondrial genome have frequently been regarded as a single functional category, alike in arrangement and hence in mode of expression. The "generic" mitochondrial mRNA is perceived as having (i) an arrangement within the polycistronic unit that permits its liberation following mt-tRNA processing, (ii) no 5' cap structure or introns, (iii) essentially no untranslated regions, and (iv) a poly(A) tail of approximately fifty nucleotides that is required in part to complete the termination codon. Closer inspection reveals that only two molecules fit this pattern. This article examines the extent to which human mitochondrial mRNA species differ from one another.
authors.affiliation: Mitochondrial Research Group, Medical School, Institute for Ageing and Health, Newcastle University, Framlington Place, Newcastle upon Tyne, NE2 4HH, UK.
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Temperley
authors.forename: Mateusz
authors.initials: M
authors.lastname: Wydro
authors.forename: Robert N
authors.initials: RN
authors.lastname: Lightowlers
authors.forename: Zofia M
authors.initials: ZM
authors.lastname: Chrzanowska-Lightowlers
mesh_terms: D018387:Codon, Initiator / Q000235:genetics; D018388:Codon, Terminator / Q000235:genetics; D019143:Evolution, Molecular; D054629:Genome, Mitochondrial; D006801:Humans; D026723:Polyadenylation; D012313:RNA / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D000077278:RNA, Mitochondrial; D020506:Untranslated Regions
chemical_list: D018387:Codon, Initiator; D018388:Codon, Terminator; D012333:RNA, Messenger; D000077278:RNA, Mitochondrial; D020506:Untranslated Regions; D012313:RNA