title: Liposomal circular dichroism. Assignment of remote stereocenters in plakinic acids K and L from a Plakortis-Xestospongia sponge association.
abstract: Two new omega-phenyl polyketide peroxides, plakinic acids K and L, were isolated from a two-sponge association of Plakortis halichondroides and Xestospongia deweerdtae. The absolute configurations of the remote dimethyl-branched stereocenters in plakinic acid K were assigned by degradation of plakinic acid K to a long-chain naphthamide and analysis by liposomal circular dichroism (L-CD) and comparison with synthetic standards.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.
authors.forename: Doralyn S
authors.initials: DS
authors.lastname: Dalisay
authors.forename: Tim
authors.initials: T
authors.lastname: Quach
authors.forename: Tadeusz F
authors.initials: TF
authors.lastname: Molinski
mesh_terms: D000818:Animals; D002942:Circular Dichroism; D008081:Liposomes / Q000737:chemistry*; D008968:Molecular Conformation; D010545:Peroxides / Q000737:chemistry* / Q000302:isolation & purification; D011161:Porifera / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D008081:Liposomes; D010545:Peroxides; C550219:plakinic acid K; C550220:plakinic acid L