title: Transition-metal-free electrophilic amination between aryl Grignard reagents and N-chloroamines.
abstract: In the presence of N,N,N',N'-tetramethylethylenediamine (TMEDA) as an additive, easily prepared and handled N-chloroamines react with aryl Grignard reagents to give a variety of arylamines in good to excellent yields. Functional groups such as ester and nitrile are compatible under the reaction conditions.
authors.affiliation: International Research Center for Elements Science, Institute for Chemical Research, Kyoto University, Uji, Kyoto, 611-0011, Japan.
authors.forename: Takuji
authors.initials: T
authors.lastname: Hatakeyama
authors.forename: Yuya
authors.initials: Y
authors.lastname: Yoshimoto
authors.forename: Sujit K
authors.initials: SK
authors.lastname: Ghorai
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nakamura
mesh_terms: D000586:Amination; D002700:Chloramines / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002700:Chloramines; D009942:Organometallic Compounds; C450681:phenyllithium