title: A randomized, investigator-blinded trial to assess the antimicrobial efficacy of a benzoyl peroxide 5%/ clindamycin phosphate 1% gel compared with a clindamycin phosphate 1.2%/tretinoin 0.025% gel in the topical treatment of acne vulgaris.
abstract: BACKGROUND
  Combination products in which the individual components have different mechanisms of antimicrobial action have been shown in many disease states to provide the most effective therapy.
  
  
  METHODS
  This 16-week, two-center, investigator-blinded, randomized, parallel-group study evaluated the antimicrobial efficacy of clindamycin phosphate 1%/benzoyl peroxide 5% gel (BPO/C) as compared to a clindamycin phosphate 1.2%/tretinoin 0.025% gel (T/C) over 16 weeks in the treatment of moderate to moderately severe acne.
  
  
  RESULTS
  While subjects in both arms experienced reductions in total Propionibacterium acnes (P. acnes) counts, the BPO/C arm produced greater reductions throughout the study. Furthermore, overall reductions in the number of clindamycin-resistant and erythromycin-resistant P. acnes occurred only in BPO/C treated subjects.
  
  
  CONCLUSIONS
  These data suggest that clindamycin phosphate 1%/benzoyl peroxide 5% gel reduces P. acnes counts and mitigates the emergence of antimicrobial resistance.
authors.affiliation: Division of Dermatology, University of Louisville, Louisville, KY 40202, USA. kmmjackson@aol.com
authors.forename: J Mark
authors.initials: JM
authors.lastname: Jackson
authors.forename: Juian-Juian Jan
authors.initials: JJ
authors.lastname: Fu
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Almekinder
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001585:Benzoyl Peroxide / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002981:Clindamycin / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005782:Gels; D006801:Humans; D008297:Male; D016037:Single-Blind Method; D014212:Tretinoin / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D005782:Gels; C466951:clindamycin phosphate benzoyl peroxide combination; C117880:clindamycin, tretinoin drug combination; D002981:Clindamycin; D014212:Tretinoin; D001585:Benzoyl Peroxide