title: [A case of primary liver carcinoma of intermediate (hepatocyte-cholangiocyte) phenotype: comparison of hemodynamics and histopathology].
abstract: A 58-year-old man was followed up for HBV-associated chronic hepatitis. A low echoic hepatic nodule 1.6cm in diameter developed in segment 8 of the liver. The tumor was hypervascular and showed enhancement on CV during hepatic arteriography (CTHA) and a defect on CT during arterial portography (CTAP). Strong enhancement, which lasted for 30 seconds, was observed at the margin of the tumor on single-level dynamic CTHA. The resected tumor was whitish, had no capsule, and consisted mainly of intermediate immature cells together with HCC-like and CCC-like tumor cells. These findings led to the diagnosis of primary liver carcinoma of intermediate (hepatocyte-cholangiocyte) phenotype. Cytokeratin (CK) 7, CK8, CK19, EMA and vimentin were positive and HP-1 and c-kit tests were negative on immunohistochemical staining. Staining with CD34+alphaSMA showed more muscular arterial vessels and sinusoid-like vessels in the peripheral zone of the tumor than in the central zone. Six months after the resection of the tumor, swollen abdominal lymph nodes were observed on US and CT, which aspiration needle biopsy showed to be metastasis of a hepatic tumor.
authors.affiliation: Department of Gastroenterology and Hepatology, Osaka Red Cross Hospital, Japan. r-kita@osaka-med.jrc.or.jp
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Kita
authors.forename: Osamu
authors.initials: O
authors.lastname: Nakashima
authors.forename: Azusa
authors.initials: A
authors.lastname: Sakamoto
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nagata
authors.forename: Akihiro
authors.initials: A
authors.lastname: Minami
authors.forename: Yuji
authors.initials: Y
authors.lastname: Eso
authors.forename: Hiroo
authors.initials: H
authors.lastname: Matsuo
authors.forename: Sumio
authors.initials: S
authors.lastname: Saito
authors.forename: Masato
authors.initials: M
authors.lastname: Nakatsuji
authors.forename: Atsuyuki
authors.initials: A
authors.lastname: Ikeda
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nishikawa
authors.forename: Toru
authors.initials: T
authors.lastname: Kimura
authors.forename: Yukio
authors.initials: Y
authors.lastname: Osaki
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000503:physiopathology; D018281:Cholangiocarcinoma / Q000473:pathology / Q000503:physiopathology; D006439:Hemodynamics; D019694:Hepatitis B, Chronic / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged