Elevated plasma fibrinogen caused by inadequate alpha-linolenic acid intake can be reduced by replacing fat with canola-type rapeseed oil.
The effects of canola-type rapeseed oil (RSO) on serum lipids, plasma fibrinogen, lipid oxidation and fatty acids were studied in three groups of subjects, two of which had not been consuming fish in their habitual diets. Forty-two volunteers (35 women, 7 men, 16-62 years) replaced fat with RSO for 6 weeks in a parallel design. The average cholesterol and fibrinogen concentrations were 5.0 mmol/l and 2.6 g/l, respectively. The intake of alpha-linolenic acid (alpha-LLA) was doubled. Efficient competitive inhibition by alpha-LLA was seen as a decrease in long-chain (LC) n-6 PUFA at 3 weeks. Elevated fibrinogen (2.6-3.9 g/l) decreased by 0.95 g/l at 6 weeks. Docosahexaenoic acid (22:6n-3) in plasma phospholipids increased at low fibrinogen levels only. The associations and changes in plasma C18 and LC PUFA followed the competitive and metabolic principles of the body, and especially in the case of n-3 PUFA according to the recycling pathway.
Seppänen-Laakso
T
T
Division of Pharmaceutical Biology, Faculty of Pharmacy, University of Helsinki, Finland.
Laakso
I
I
Lehtimäki
T
T
Rontu
R
R
Moilanen
E
E
Solakivi
T
T
Seppo
L
L
Vanhanen
H
H
Kiviranta
K
K
Hiltunen
R
R
D000293:Adolescent; D000328:Adult; D005229:Fatty Acids, Monounsaturated / Q000008:administration & dosage*; D043371:Fatty Acids, Omega-6 / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood; D000074262:Rapeseed Oil; D013997:Time Factors; D017962:alpha-Linolenic Acid / Q000008:administration & dosage / Q000009:adverse effects*
D005229:Fatty Acids, Monounsaturated; D043371:Fatty Acids, Omega-6; D010743:Phospholipids; D000074262:Rapeseed Oil; D017962:alpha-Linolenic Acid; D005340:Fibrinogen