Alphaherpesvirus use and misuse of cellular actin and cholesterol.
Two major structural elements of a cell are the cytoskeleton and the lipid membranes. Actin and cholesterol are key components of the cytoskeleton and membranes, respectively, and are involved in a plethora of different cellular processes. This review summarizes and discusses the interaction of alphaherpesviruses with actin and cholesterol during different stages of the replication cycle: virus entry, replication and assembly in the nucleus, and virus egress. Elucidating these interactions not only yields novel insights into the biology of these important pathogens, but may also shed new light on cell biological aspects of actin and cholesterol, and lead to novel avenues in the design of antiviral strategies.
Favoreel
Herman W
HW
Department of Virology, Parasitology, and Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium. Herman.Favoreel@UGent.be
Van den Broeke
Céline
C
Desplanques
Ann
A
Deruelle
Matthias
M
Van Minnebruggen
Geert
G
Nauwynck
Hans
H
Glorieux
Sarah
S
Van Opdenbosch
Nina
N
De Regge
Nick
N
D000199:Actins / Q000378:metabolism*; D018138:Alphaherpesvirinae / Q000502:physiology*; D000818:Animals; D002467:Cell Nucleus / Q000821:virology; D002784:Cholesterol / Q000378:metabolism*; D003599:Cytoskeleton / Q000821:virology; D004261:DNA Replication; D006566:Herpesviridae Infections / Q000821:virology*; D054884:Host-Pathogen Interactions; D006801:Humans; D019065:Virus Assembly; D053586:Virus Internalization; D057074:Virus Release
D000199:Actins; D002784:Cholesterol