title: Comparison of elastography, serum marker scores, and histology for the assessment of liver fibrosis in hepatitis B virus (HBV)-infected patients in Burkina Faso.
abstract: Liver fibrosis (LF) must be assessed before talking treatment decisions in hepatitis B. In Burkina Faso, liver biopsy (LB) remains the "gold standard" method for this purpose. Access to treatment might be simpler if reliable alternative techniques for LF evaluation were available. The hepatitis B virus (HBV)-infected patients who underwent LB was invited to have liver stiffness measurement (Fibroscan) and serum marker assays. Fifty-nine patients were enrolled. The performance of each technique for distinguishing F0F1 from F2F3F4 was compared. The area under receiver operating characteristic (AUROC) curves was 0.61, 0.71, 0.79, 0.82, and 0.87 for the aspartate transaminase to platelet ratio index (APRI), Fib-4, Fibrotest, Fibrometre, and Fibroscan. Elastometric thresholds were identified for significant fibrosis and cirrhosis. Combined use of Fibroscan and a serum marker could avoid 80% of biopsies. This study shows that the results of alternative methods concord with those of histology in HBV-infected patients in Burkina Faso. These alternative techniques could help physicians to identify patients requiring treatment.
authors.affiliation: Maladies Infectieuses, Hôpital Tenon, UPMC Univ Paris 06, UPMC Paris Liver Center, Paris, France. philippe.bonnard@tnn.aphp.fr
authors.forename: Philippe
authors.initials: P
authors.lastname: Bonnard
authors.forename: Roger
authors.initials: R
authors.lastname: Sombié
authors.forename: Francois-Xavier
authors.initials: FX
authors.lastname: Lescure
authors.forename: Alain
authors.initials: A
authors.lastname: Bougouma
authors.forename: Jean Baptiste
authors.initials: JB
authors.lastname: Guiard-Schmid
authors.forename: Thierry
authors.initials: T
authors.lastname: Poynard
authors.forename: Paul
authors.initials: P
authors.lastname: Calès
authors.forename: Chantal
authors.initials: C
authors.lastname: Housset
authors.forename: Patrice
authors.initials: P
authors.lastname: Callard
authors.forename: Catherine
authors.initials: C
authors.lastname: Le Pendeven
authors.forename: Joseph
authors.initials: J
authors.lastname: Drabo
authors.forename: Fabrice
authors.initials: F
authors.lastname: Carrat
authors.forename: Gilles
authors.initials: G
authors.lastname: Pialoux
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood*; D002050:Burkina Faso / Q000453:epidemiology; D054459:Elasticity Imaging Techniques; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000188:drug therapy; D006515:Hepatitis B virus; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000175:diagnosis*; D008297:Male; D019562:Viral Load; D055815:Young Adult
chemical_list: D000998:Antiviral Agents; D015415:Biomarkers