Maternal plasma P-selectin at 11 to 13 weeks of gestation in hypertensive disorders of pregnancy.
OBJECTIVE
To determine if development of preeclampsia is preceded by altered maternal plasma P-selectin and if the levels are related with uterine artery pulsatility index.


METHODS
Plasma P-selectin and uterine artery pulsatility index were measured at 11-13 weeks in 121 cases that subsequently developed preeclampsia, 87 cases that developed gestational hypertension and 208 unaffected controls.


RESULTS
In the preeclampsia group the median multiple of the median in controls (MoM) P-selectin and uterine artery PI were significantly increased (1.2 MoM and 1.3 MoM). There was no significant association between P-selectin and uterine artery pulsatility index in either the preeclampsia or control group.


CONCLUSIONS
In pregnancies that develop preeclampsia there is evidence of platelet activation from the first trimester. However, there is no direct link between the degree of impaired placentation and platelet activation.
Akolekar
Ranjit
R
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, London, UK.
Veduta
Alina
A
Minekawa
Ryoko
R
Chelemen
Teodora
T
Nicolaides
Kypros H
KH
D000328:Adult; D005260:Female; D006801:Humans; D046110:Hypertension, Pregnancy-Induced / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D019007:P-Selectin / Q000097:blood*; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood*; D011446:Prospective Studies; D011673:Pulsatile Flow / Q000502:physiology; D014463:Ultrasonography; D055988:Uterine Artery / Q000000981:diagnostic imaging / Q000503:physiopathology
D019007:P-Selectin