title: Influence of human cytomegalovirus infection on the NK cell receptor repertoire in children.
abstract: Human cytomegalovirus (hCMV) infection is usually asymptomatic but may cause disease in immunocompromised hosts. It has been reported that hCMV infection may shape the NK cell receptor (NKR) repertoire in adult individuals, promoting a variable expansion of the CD94/NKG2C+ NK cell subset. We explored the possible relationship between this viral infection and the expression pattern of different NKR including CD94/NKG2C, CD94/NKG2A, immunoglobulin-like transcript 2 (ILT2, CD85j), KIR2DL1/2DS1, KIR3DL1, and CD161 in peripheral blood lymphocytes from healthy children, seropositive (n=21) and seronegative (n=20) for hCMV. Consistent with previous observations in adults, a positive serology for hCMV was associated with increased numbers of NKG2C+ NK and T cells as well as with ILT2+ T lymphocytes. Moreover, the proportions of CD161+ and NKG2C+CD56-CD3- NK cells also tended to be increased in hCMV+ individuals. Excretion of the virus was associated with higher proportions of NKG2C+ NK cells. Altogether, these data reveal that hCMV may have a profound influence on the NKR repertoire in early childhood.
authors.affiliation: Department of Immunology, Facultad de Medicina, Universidad Autónoma de San Luis Potosí, San Luis Potosí, Mexico.
authors.forename: Adriana
authors.initials: A
authors.lastname: Monsiváis-Urenda
authors.forename: Daniel
authors.initials: D
authors.lastname: Noyola-Cherpitel
authors.forename: Alba
authors.initials: A
authors.lastname: Hernández-Salinas
authors.forename: Christian
authors.initials: C
authors.lastname: García-Sepúlveda
authors.forename: Neus
authors.initials: N
authors.lastname: Romo
authors.forename: Lourdes
authors.initials: L
authors.lastname: Baranda
authors.forename: Miguel
authors.initials: M
authors.lastname: López-Botet
authors.forename: Roberto
authors.initials: R
authors.lastname: González-Amaro
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D015703:Antigens, CD / Q000096:biosynthesis / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification; D003586:Cytomegalovirus Infections / Q000097:blood / Q000276:immunology* / Q000652:urine; D005260:Female; D015967:Gene Expression Regulation, Viral; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007223:Infant; D007694:Killer Cells, Natural / Q000145:classification / Q000276:immunology* / Q000378:metabolism; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D008297:Male; D055651:NK Cell Lectin-Like Receptor Subfamily B / Q000096:biosynthesis / Q000235:genetics; D055654:NK Cell Lectin-Like Receptor Subfamily C / Q000096:biosynthesis / Q000235:genetics; D051920:NK Cell Lectin-Like Receptor Subfamily D / Q000096:biosynthesis / Q000235:genetics; D011971:Receptors, Immunologic / Q000096:biosynthesis / Q000235:genetics; D055607:Receptors, Natural Killer Cell / Q000096:biosynthesis* / Q000235:genetics; D012463:Saliva / Q000821:virology; D014556:Urine / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D015703:Antigens, CD; D007074:Immunoglobulin G; C527203:KLRB1 protein, human; C527059:KLRC2 protein, human; C497869:KLRD1 protein, human; C105299:LILRB1 protein, human; D000075362:Leukocyte Immunoglobulin-like Receptor B1; D055651:NK Cell Lectin-Like Receptor Subfamily B; D055654:NK Cell Lectin-Like Receptor Subfamily C; D051920:NK Cell Lectin-Like Receptor Subfamily D; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell