title: Long-term outcome of patients with high-risk prostate cancer following radical prostatectomy and stage-dependent adjuvant androgen deprivation.
abstract: OBJECTIVE
  To present the long-term outcome of high-risk prostate cancer patients treated by radical retropubic prostatectomy (RRP) and stage-dependent adjuvant androgen deprivation therapy.
  
  
  METHODS
  Between 1989 and 2005, 2,655 patients underwent RRP by 9 surgeons. All cases (n = 372) with high-risk prostate cancer (serum PSA >20 ng/ml, and/or clinical stage T2c or greater, and/or biopsy Gleason score 8 or greater) were identified and analyzed retrospectively.
  
  
  RESULTS
  At 5 and 10 years, cancer-specific survival was 91.3 and 87.2%; overall survival was 84.3 and 72.1%; biochemical progression-free survival (BPFS) was 76.6 and 56.2%; clinical progression-free survival was 86.2 and 79.9%. Kaplan-Meier analysis showed significant differences with respect to pathological stage and Gleason score for cancer-specific survival, BPFS and clinical progression-free survival. In multiple analysis, the only preoperative predictor of BPFS at the 5% level was clinical stage (p = 0.0055).
  
  
  CONCLUSIONS
  In patients with high-risk prostate cancer and a life expectancy of more than 10 years, RRP with stage-dependent adjuvant androgen deprivation therapy is a viable alternative to radiation therapy.
authors.affiliation: Department of Urology, Städtisches Klinikum Karlsruhe, Karlsruhe, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Spahn
authors.forename: Christel
authors.initials: C
authors.lastname: Weiss
authors.forename: Pia
authors.initials: P
authors.lastname: Bader
authors.forename: Philipp
authors.initials: P
authors.lastname: Ströbel
authors.forename: Elmar W
authors.initials: EW
authors.lastname: Gerharz
authors.forename: Burkard
authors.initials: B
authors.lastname: Kneitz
authors.forename: Detlef
authors.initials: D
authors.lastname: Frohneberg
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000728:Androgens / Q000378:metabolism; D018572:Disease-Free Survival; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging / Q000379:methods; D011468:Prostatectomy / Q000379:methods*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000728:Androgens