title: Evaluation of O-(2-[18F]-Fluoroethyl)-L-Tyrosine in the Diagnosis of Glioblastoma.
abstract: OBJECTIVE
  To assess the feasibility of synthesis of O-(2-[(18)F]-fluoroethyl)-l-tyrosine (FET), a new positron emission tomographic (PET) tracer described in several studies but not yet considered standard in management of glioma, in routine practice and to determine FET uptake in a homogeneous group of patients with suspected high-grade glioma.
  
  
  METHODS
  Prospective nonrandomized trial.
  
  
  METHODS
  Twelve patients with suspicion of high-grade glioma.
  
  
  RESULTS
  The mean (SD) FET uptake ratio was 3.15 (0.72) for the 12 patients and 3.16 (0.75) for the 11 patients with glioblastoma.
  
  
  CONCLUSIONS
  The initial results are promising and indicate that FET PET is a valuable and applicable tool for the imaging of high-grade glioma.
authors.affiliation: Pole NeuroSciences, CHU Toulouse Purpan, Place du Dr Baylac, 31059 Toulouse Cedex, France. benouaich-amiel.a@chu-toulouse.fr.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Benouaich-Amiel
authors.forename: Vincent
authors.initials: V
authors.lastname: Lubrano
authors.forename: Mathieu
authors.initials: M
authors.lastname: Tafani
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Uro-coste
authors.forename: Pierre
authors.initials: P
authors.lastname: Gantet
authors.forename: Jean Christophe
authors.initials: JC
authors.lastname: Sol
authors.forename: Franck
authors.initials: F
authors.lastname: Roux
authors.forename: Philippe
authors.initials: P
authors.lastname: Bousquet
authors.forename: Anne
authors.initials: A
authors.lastname: Julian
authors.forename: Jean
authors.initials: J
authors.lastname: Sabatier
authors.forename: Michel
authors.initials: M
authors.lastname: Tremoulet
authors.forename: Valerie
authors.initials: V
authors.lastname: Cances-Lauwers
authors.forename: Marie Bernadette
authors.initials: MB
authors.lastname: Delisle
authors.forename: Michel
authors.initials: M
authors.lastname: Clanet
authors.forename: Jean Philippe
authors.initials: JP
authors.lastname: Esquerré
authors.forename: Pierre
authors.initials: P
authors.lastname: Payoux
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D005909:Glioblastoma / Q000000981:diagnostic imaging*; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D007091:Image Processing, Computer-Assisted; D049268:Positron-Emission Tomography / Q000379:methods*; D011446:Prospective Studies; D014443:Tyrosine / Q000031:analogs & derivatives*
chemical_list: C117289:O-(2-fluoroethyl)tyrosine; D014443:Tyrosine