A dinuclear nickel complex modeling of the Ni(d)(II)-Ni(p)(I) state of the active site of acetyl CoA synthase.
The dinuclear Ni(II)-Ni(I) complex Ni(II)(dadt(Et))Ni(I)(SDmp)(PPh(3)) was synthesized as a Ni(II)(d)-Ni(I)(p) model of the A-cluster in acetyl CoA synthase. This complex was reacted with Co(dmgBF(2))(2)(Me)(Py) and KSDmp successively to afford Ni(dadt(Et))Ni(Me)(SDmp), which further reacts with CO to afford the acetylthioester CH(3)C(O)SDmp via reductive elimination.
Matsumoto
Tsuyoshi
T
Research Center for Materials Science, and Department of Chemistry, Graduate School of Science, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8602, Japan. i45100a@nucc.cc.nagoya-u.ac.jp
Ito
Mikinao
M
Kotera
Mai
M
Tatsumi
Kazuyuki
K
D000106:Acetate-CoA Ligase / Q000737:chemistry*; D020134:Catalytic Domain; D008958:Models, Molecular; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D011487:Protein Conformation
D009532:Nickel; D000106:Acetate-CoA Ligase