Synthesis of N-substituted iminosugar derivatives and their immunosuppressive activities.
Several N-alkyl and hydroxyethyl-substituted iminosugar derivatives, including L-altro and D-galacto epimers, were synthesized and the effects of these synthetic iminosugars on proliferation of mouse splenocytes were evaluated in the MTT assay. The experimental data demonstrated that the N-alkylated D-galacto iminosugars showed better inhibitory activities than L-altro analogues, which might hold potential as immunosuppressive agents.
Zhang
Guo-Liang
GL
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Xue Yuan Road #38, Beijing, China.
Chen
Changshui
C
Xiong
Yulan
Y
Zhang
Li-He
LH
Ye
Jia
J
Ye
Xin-Shan
XS
D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects; D050111:Imino Sugars / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000166:cytology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D050111:Imino Sugars; D007166:Immunosuppressive Agents