title: Variation of interstitial glucose measurements assessed by continuous glucose monitors in healthy, nondiabetic individuals.
abstract: OBJECTIVE
  To characterize glucose levels during daily living using continuous glucose monitors (CGMs) in nondiabetic individuals.
  
  
  METHODS
  Seventy-four healthy children, adolescents, and adults aged 9-65 years with normal glucose tolerance used a blinded CGM device for 3 to 7 days.
  
  
  RESULTS
  Sensor glucose concentrations were 71-120 mg/dl for 91% of the day. Sensor values were <or=60 or >140 mg/dl for only 0.2% and 0.4% of the day, respectively. Sensor glucose concentrations were slightly higher in children than adults (P = 0.009) and were slightly lower during the night than day (95 vs. 99 mg/dl, P < 0.001).
  
  
  CONCLUSIONS
  Glucose values <or=60 and >140 mg/dl, measured with CGM, are uncommon in healthy, nondiabetic individuals. CGM may be useful to evaluate glucose tolerance in nondiabetic individuals over time. Furthermore, these data provide a basis for comparison for studies that use CGM to assess glucose control in subjects with diabetes.
authors.forename: Larry A
authors.initials: LA
authors.lastname: Fox
authors.forename: Roy W
authors.initials: RW
authors.lastname: Beck
authors.forename: Dongyuan
authors.initials: D
authors.lastname: Xing
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D015190:Blood Glucose Self-Monitoring; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018670:Monitoring, Ambulatory; D055815:Young Adult
chemical_list: D001786:Blood Glucose