title: The molecular pathogenesis of Ewing's sarcoma.
abstract: Ewing sarcoma family tumors (ESFT) are a group of aggressive solid bone and soft tissue malignancies of children and young adults characterized by specific chromosomal translocations that give rise to EWS-ETS aberrant transcription factors. Identification of EWS-ETS target genes and their role in tumor signaling networks together with the unravelling of the cell of origin will facilitate the translation into new treatment modalities for these neoplasms.
authors.affiliation: Laboratory of Molecular Pathology of Sarcomas, Centro de Investigación del Cáncer-Instituto de Biología Molecular y Celular del Cáncer, Universidad de Salamanca-CSIC, Salamanca, Spain.
authors.forename: Carlos
authors.initials: C
authors.lastname: Mackintosh
authors.forename: Juan
authors.initials: J
authors.lastname: Madoz-Gúrpide
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Ordóñez
authors.forename: Daniel
authors.initials: D
authors.lastname: Osuna
authors.forename: David
authors.initials: D
authors.lastname: Herrero-Martín
mesh_terms: D006801:Humans; D012512:Sarcoma, Ewing / Q000209:etiology* / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology