Evaluation of intralesional 0.2% ciprofloxacin as a treatment for cutaneous leishmaniasis.
Although cutaneous leishmaniasis lesions usually heal spontaneously they cause unsightly scarring. This study evaluated a possible new therapy in 38 patients, with 70 lesions, randomly assigned to intralesional injection of ciprofloxacin (0.2%) or intralesional sodium chloride hypertonic solution (7%). After excluding patients who defaulted on treatment, lesions assigned to sodium chloride treatment (n = 21) were completely healed (with or without scarring) in 76.2% of cases, and, when a scar remained, the scar size was reduced 66.0% compared with the original lesion. Lesions assigned to ciprofloxacin (n = 27) showed an 81.5% healing rate with an average scar size reduction of 68.6%. Intralesional 0.2% ciprofloxacin was as effective as hypertonic saline in the treatment of cutaneous leishmaniasis infection.
Al Hamdi
K
K
Department of Dermatology, College of Medicine, University of Basra, Basra, Iraq. Khalil_hamdi2003@yahoo.com
Awad
A H
AH
Moker
H M
HM
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D002921:Cicatrix / Q000469:parasitology / Q000517:prevention & control; D002939:Ciprofloxacin / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D015552:Injections, Intralesional; D007493:Iraq; D016773:Leishmaniasis, Cutaneous / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012462:Saline Solution, Hypertonic / Q000008:administration & dosage; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014945:Wound Healing
D012462:Saline Solution, Hypertonic; D002939:Ciprofloxacin