title: Adiposity is not altered in preterm infants fed with a nutrient-enriched formula after hospital discharge.
abstract: To determine whether adiposity was altered, body size (weight, length) and composition, determined by dual energy x-ray absorptiometry, were examined in preterm infants fed with a nutrient enriched (A, n=56), a term infant (B, n=57) or the nutrient enriched (discharge and term) plus the term formula (term and 6 mo; C, n=26), and a group of breast-fed preterm infants (D, n=25) at hospital discharge, 3, 6, and 12 mo corrected age. The results were analyzed using standard statistics. One hundred sixty-four infants (birth weight=1406+/-248 g, GA=31+/-1.7 wk) were studied. All infants underwent "catch-up," but weight and length were greater in infants in group A compared with groups B, C, or D. More rapid and complete "catch-up" was paralleled by increased total nonfat and fat mass (g) but not percentage of fat mass. Changes in fat mass (g) were primarily explained by increased fat accretion on the legs. More rapid and complete "catch-up" growth, therefore, reflected increased nonfat and peripheral fat mass. These data do not support the hypothesis of increased or central adiposity in infants fed a nutrient-enriched formula after hospital discharge.
authors.affiliation: Department of Pediatrics, Cardinal Glennon Children's Hospital, St Louis, Missouri 63104, USA. richardjcooke@mac.com
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Cooke
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Griffin
authors.forename: Kenny
authors.initials: K
authors.lastname: McCormick
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity; D000367:Age Factors; D001724:Birth Weight; D001827:Body Height; D001942:Breast Feeding; D002508:Cephalometry; D004311:Double-Blind Method; D005260:Female; D006257:Head / Q000033:anatomy & histology; D006801:Humans; D007223:Infant; D041943:Infant Formula; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D007234:Infant, Premature / Q000254:growth & development*; D008297:Male; D010351:Patient Discharge; D011446:Prospective Studies; D015430:Weight Gain