Early vascular phenotypes in the genesis of hypertension.
Cardiovascular complications occurring in adults find their roots in risk factors operating early in life. Among the factors influencing cardiovascular risk, blood pressure values in children represent an important measurable marker of the level of potential cardiovascular risk later in life because the levels are both the cause and the consequence of early vascular alterations. Early vascular phenotypes represent a field of great interest, and they can be studied through indirect assessment using non-invasive techniques. Estimations of blood pressure components, pulse wave velocity, and reflecting waves provide valuable information that can be easily recorded and repeated overtime. A direct assessment, carried out by examining the umbilical vessels, can add further valuable information. In this review, we discuss the potential application of surrogate markers of early vascular alterations and describe the information provided by umbilical cord vessels.
Lurbe
Empar
E
Department of Pediatrics, Consorcio Hospital General, University of Valencia, Avda Tres Cruces s/n, 46014 Valencia, Spain. empar.lurbe@uv.es
Torró
Maria Isabel
MI
D000293:Adolescent; D015415:Biomarkers; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000502:physiology*; D002478:Cells, Cultured; D002648:Child; D004730:Endothelium, Vascular / Q000002:abnormalities / Q000166:cytology; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D010641:Phenotype; D012307:Risk Factors; D018608:Ultrasonography, Doppler; D014469:Umbilical Arteries / Q000002:abnormalities* / Q000166:cytology / Q000503:physiopathology; D014471:Umbilical Veins / Q000002:abnormalities* / Q000166:cytology / Q000503:physiopathology
D015415:Biomarkers