[Structural and functional disorders of erythrocyte cell membrane in patients with Crohn's disease].
Investigation of erythrocyte membrane in patients with Crohn's disease detected the changes in asymmetry of its molecular components, abnormalities in normal functioning of membrane-associated enzymes and energy-dependent processes in the cell. The mechanism of damaging effect on the cell membrane was caused by the excessive blood accumulation of a composite complex of low-molecular substances, compounds of quinone and carbohydrate nature, peptides, modified forms of nucleotides. The revealed changes make it possible to assess the severity of endogenous intoxication and cell membrane disorder, which take place not only in the course of the disease acute attack, but also retain during the period of incomplete clinical and endoscopic remission.
Chashkova
E Iu
EIu
Gorokhova
V G
VG
Kuznetsova
E E
EE
Korotaeva
N S
NS
Grigor'ev
E G
EG
Pak
V E
VE
Barakov
R F
RF
D000293:Adolescent; D000328:Adult; D003424:Crohn Disease / Q000378:metabolism* / Q000473:pathology*; D004910:Erythrocyte Membrane / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008875:Middle Aged