Genome-wide analysis of the replication program in mammals.
Microarray technology has facilitated the research of eukaryotic DNA replication on a genome-wide scale. Recent studies have shed light on the association between time of replication and chromosome structure, on the organization principles of the replication program, and on the correlation between replication timing and transcription. In this review, we summarize various genomic measurement approaches and the biological insights achieved through applying them in the study of the mammalian replication program.
Farkash-Amar
Shlomit
S
Department of Microbiology and Molecular Genetics, The Institute for Medical Research-Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Simon
Itamar
I
D000818:Animals; D004261:DNA Replication; D044127:Epigenesis, Genetic; D016678:Genome; D042822:Genomic Instability; D017404:In Situ Hybridization, Fluorescence; D020411:Oligonucleotide Array Sequence Analysis