title: Microbial metabolism of cannflavin A and B isolated from Cannabis sativa.
abstract: Microbial metabolism of cannflavin A (1) and B (2), two biologically active flavonoids isolated from Cannabis sativa L., produced five metabolites (3-7). Incubation of 1 and 2 with Mucor ramannianus (ATCC 9628) and Beauveria bassiana (ATCC 13144), respectively, yielded 6''S,7''-dihydroxycannflavin A (3), 6''S,7''-dihydroxycannflavin A 7-sulfate (4) and 6''S,7''-dihydroxycannflavin A 4'-O-alpha-L-rhamnopyranoside (5), and cannflavin B 7-O-beta-D-4'''-O-methylglucopyranoside (6) and cannflavin B 7-sulfate (7), respectively. All compounds were evaluated for antimicrobial and antiprotozoal activity.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
authors.forename: Amany K
authors.initials: AK
authors.lastname: Ibrahim
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Radwan
authors.forename: Safwat A
authors.initials: SA
authors.lastname: Ahmed
authors.forename: Desmond
authors.initials: D
authors.lastname: Slade
authors.forename: Samir A
authors.initials: SA
authors.lastname: Ross
authors.forename: Mahmoud A
authors.initials: MA
authors.lastname: ElSohly
authors.forename: Ikhlas A
authors.initials: IA
authors.lastname: Khan
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D052982:Beauveria / Q000378:metabolism*; D002188:Cannabis / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009089:Mucor / Q000378:metabolism*; D021261:Parasitic Sensitivity Tests
chemical_list: D000890:Anti-Infective Agents; D000981:Antiprotozoal Agents; D047309:Flavones; C045457:cannflavin