[The influence of estazolam on human neurobehavioral function].
OBJECTIVE
To study the relation between human blood estazolam concentration and neurobehavioral function.


METHODS
The neurobehavioral ability of 10 volunteers were measured with computer-administered neurobehavioral evaluation system-chinese3 (NES-C3) and SMART EquiTest system.


RESULTS
The neurobehavioral ability and balance function declined 1 h later after dosing estazolam. The neurobehavioral ability index and balance function declined to the lowest level 3 h later after dosing estazolam. The neurobehavioral ability recovered partly 6 h later after dosing estazolam, and neurobehavioral ability recovered completely 10 h later.


CONCLUSIONS
Driving ability was impaired when estazolam concentration in blood is 20 ng/mL, and the neurobehavioral ability declined when estazolam concentration is 40 ng/mL in blood. The influence to human in absorption process is greater than the metabolic process with the same estazolam concentration.
Shanghai Key Laboratory of Forensic Medicine, Institute of Forensic Science, Ministry of Justice, PR China, Shanghai 200063, China.
Jun
J
Bu
Xian-yi
XY
Zhuo
D000063:Accidents, Traffic / Q000517:prevention & control*; D000284:Administration, Oral; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics; D001288:Attention / Q000187:drug effects*; D001519:Behavior / Q000187:drug effects*; D004949:Estazolam / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time
D000927:Anticonvulsants; D004949:Estazolam