Novel Burkholderiales 23S rRNA genes identified in ileal biopsy samples from children: preliminary evidence that a subtype is associated with perianal Crohn's disease.
A novel family of Burkholderiales bacteria was identified in ileal biopsy specimens from children presenting with symptoms of inflammatory bowel disease. A molecular subtyping approach based on sequencing of a variable region of the bacteria's 23S rRNA genes identified three variants. Pilot analysis identified one variant to be significantly associated with perianal Crohn's disease.
Enteric Virus Group, Murdoch Childrens Research Institute, Parkville, Victoria 3052, Australia. winnie.sim@mcri.edu.au
W H
WH
Sim
J
J
Wagner
D J
DJ
Cameron
A G
AG
Catto-Smith
R F
RF
Bishop
C D
CD
Kirkwood
D000293:Adolescent; D001706:Biopsy; D019117:Burkholderia / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D003424:Crohn Disease / Q000382:microbiology*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D006801:Humans; D007082:Ileum / Q000382:microbiology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D017422:Sequence Analysis, DNA
D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012338:RNA, Ribosomal, 23S