Vascular redox imbalance in rats submitted to chronic exercise.
Exercise training has been used for treatment/prevention of many cardiovascular diseases, but the mechanisms need to be clarified. Thus, our aim was to compare oxidative stress parameters between rats submitted to a swimming training and sedentary rats (control). Twelve male rats were divided into two groups: control and exercise training. The exercise training had daily 1 h swimming sessions for 8 weeks and a load (5% of its body mass) was placed in rat's tail. Thereafter the animals were killed, aorta and heart were surgically removed and blood was collected. Body mass gain, thiobarbituric acid reactive species (TBARS), carbonyl content, total reactive antioxidant potential (TRAP), total antioxidant reactivity (TAR), superoxide dismutase (SOD) activity and catalase (CAT) activity were evaluated. The trained rats showed a lower body mass gain and no modifications on heart. An increased SOD activity was observed on aorta after the training, but no changes were seen for CAT activity, which led to an increased SOD/CAT ratio. The arterial TBARS was also increased for trained rats. The decrease in TRAP in exercise training was the single modification on plasma. Our findings suggest that the increased SOD activity could play a role in vascular adaptations to exercise training.
da Rocha
Ricardo Fagundes
RF
Center of Oxidative Stress Research (CEEO), Professor Tuiskon Dick Departament of Biochemistry, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. 00140244@ufrgs.br
de Oliveira
Marcos Roberto
MR
Pasquali
Matheus Augusto de Bittencourt
MA
Andrades
Michael Everton
ME
Oliveira
Max William Soares
MW
Behr
Guilherme Antônio
GA
Moreira
José Cláudio Fonseca
JC
D000293:Adolescent; D000328:Adult; D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001011:Aorta / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D010805:Physical Conditioning, Animal / Q000502:physiology*; D050050:Protein Carbonylation; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism; D013858:Thiobarbiturates / Q000378:metabolism
D000975:Antioxidants; D013858:Thiobarbiturates; D002374:Catalase; D013482:Superoxide Dismutase; C029684:thiobarbituric acid