Does hypothyroidism affect gastrointestinal motility?
BACKGROUND
Gastrointestinal motility and serum thyroid hormone levels are closely related. Our aim was to analyze whether there is a disorder in esophagogastric motor functions as a result of hypothyroidism.


METHODS
The study group included 30 females (mean age +/- SE 45.17 +/- 2.07 years) with primary hypothyroidism and 10 healthy females (mean age +/- SE 39.40 +/- 3.95 years). All cases underwent esophagogastric endoscopy and scintigraphy. For esophageal scintigraphy, dynamic imaging of esophagus motility protocol, and for gastric emptying scintigraphy, anterior static gastric images were acquired.


RESULTS
The mean esophageal transit time (52.56 +/- 4.07 sec for patients; 24.30 +/- 5.88 sec for controls; P = .02) and gastric emptying time (49.06 +/- 4.29 min for the hypothyroid group; 30.4 +/- 4.74 min for the control group; P = .01) were markedly increased in cases of hypothyroidism.


CONCLUSIONS
Hypothyroidism prominently reduces esophageal and gastric motor activity and can cause gastrointestinal dysfunction.
Yaylali
Olga
O
Department of Nuclear Medicine, Faculty of Medicine, Pamukkale University, Doktorlar Caddesi no. 42, Denizli 20100, Turkey. olgataskaya@yahoo.com
Kirac
Suna
S
Yilmaz
Mustafa
M
Akin
Fulya
F
Yuksel
Dogangun
D
Demirkan
Nese
N
Akdag
Beyza
B