The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis.
The aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis has not been well defined. Here we review two factors which may play a role in the pathogenesis of the disease: genetics and infection. In particular, we discuss the role of autoantibodies to LAMP-2, which may arise following infection with Gram-negative bacteria, and may contribute to the development of ANCA-associated systemic vasculitis in genetically susceptible individuals.
Willcocks
Lisa C
LC
Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.
Lyons
Paul A
PA
Rees
Andrew J
AJ
Smith
Kenneth G C
KG
D000818:Animals; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000235:genetics* / Q000276:immunology* / Q000382:microbiology*; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001424:Bacterial Infections / Q000150:complications / Q000276:immunology*; D003429:Cross Reactions; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D052119:Lysosomal-Associated Membrane Protein 2 / Q000276:immunology; D018716:Molecular Mimicry
D001323:Autoantibodies; D001324:Autoantigens; D052119:Lysosomal-Associated Membrane Protein 2