Outcomes of 75 patients over 12 years treated for acoustic neuromas with linear accelerator-based radiosurgery.
The aim of this study was to investigate the efficacy of linear accelerator (LINAC)-based radiosurgery in the treatment of acoustic neuromas. In this retrospective study, we enrolled 75 patients with non-neurofibromatosis type 2 acoustic neuromas who were followed-up for more than 5years. The 75 patients were divided into 3 groups: patients with a newly diagnosed tumor; those with a residual tumor; and those with a recurrent tumor. The average follow-up period was 97.8months. The overall tumor progression-free rate was 92%, and corresponding rates among those with newly diagnosed tumors was 100%, residual tumors was 84.4%, and recurrent tumors was 92.8% (p=0.028). Lesion localization using CT scans correlated with a higher tendency for tumor progression than lesion localization using CT-MRI fusion images (15.6% versus 2.4%, respectively). Residual tumors treated with radiosurgery have a higher progression rate, and careful lesion localization using CT-MRI image fusion is required.
Department of Neurosurgery, Chang Gung Memorial Hospital at Linkou, Chang Gung University, 5 Fu-Hsing St., Kweishan, Taoyuan 333, Taiwan.
Peng-Wei
PW
Hsu
Cheng-Nen
CN
Chang
Shih-Tseng
ST
Lee
Yin-Cheng
YC
Huang
Hsien-Chih
HC
Chen
Chun-Chieh
CC
Wang
Yung-Hsin
YH
Hsu
Chen-Kan
CK
Tseng
Yao-Liang
YL
Chen
Kuo-Cheng
KC
Wei
D000328:Adult; D000368:Aged; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000000981:diagnostic imaging / Q000601:surgery*; D011859:Radiography; D016634:Radiosurgery / Q000295:instrumentation*; D016896:Treatment Outcome