One-year duration of immunity induced by vaccination with a canine Lyme disease bacterin.
Laboratory-reared beagles were vaccinated with a placebo or a bacterin comprised of Borrelia burgdorferi S-1-10 and ospA-negative/ospB-negative B. burgdorferi 50772 and challenged after 1 year with B. burgdorferi-infected Ixodes scapularis ticks. For the placebo recipients, spirochetes were recovered from 9 (60%) skin biopsy specimens collected after 1 month, and the organisms persisted in the skin thereafter. Ten (67%) dogs also developed joint infection (3 dogs), lameness or synovitis (7 dogs), or B. burgdorferi-specific antibodies (8 dogs). For the vaccine recipients, spirochetes were recovered from 6 (40%) skin biopsy specimens collected after 1 month. However, subsequent biopsy specimens were negative, and the dogs failed to develop joint infection (P = 0.224), lameness/synovitis (P = 0.006), or Lyme disease-specific antibody responses (P = 0.002). The bacterin provided a high level of protection for 1 year after immunization, and the addition of the OspC-producing B. burgdorferi 50772 provided enhanced protection.
LaFleur
Rhonda L
RL
Intervet/Schering-Plough Animal Health Corporation, 21401 W. Center Road, Elkhorn, NE 68022-2202, USA. rhonda.lafleur@sp.intervet.com
Callister
Steven M
SM
Dant
Jennifer C
JC
Jobe
Dean A
DA
Lovrich
Steven D
SD
Warner
Thomas F
TF
Wasmoen
Terri L
TL
Schell
Ronald F
RF
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001170:Arthritis, Infectious / Q000382:microbiology / Q000517:prevention & control; D001706:Biopsy; D025065:Borrelia burgdorferi / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D018884:Ixodes / Q000382:microbiology; D008193:Lyme Disease / Q000517:prevention & control / Q000662:veterinary*; D022123:Lyme Disease Vaccines / Q000008:administration & dosage / Q000276:immunology*; D010919:Placebos / Q000008:administration & dosage; D017192:Skin Diseases, Bacterial / Q000382:microbiology / Q000517:prevention & control; D013997:Time Factors
D000907:Antibodies, Bacterial; D022123:Lyme Disease Vaccines; D010919:Placebos