Structure-based discovery of natural-product-like TNF-α inhibitors.
Small but effective: two natural-product-like inhibitors of tumor necrosis factor α (TNF-α; represented in green in the picture) have been identified using structure-based virtual screening. These compounds represent only the third and fourth examples of direct targeting of TNF-α by a small molecule, and display potency comparable to that of the strongest TNF-α inhibitor reported to date.
Chan
Daniel Shiu-Hin
DS
Department of Chemistry, The University of Hong Kong, China.
Lee
Ho-Man
HM
Yang
Fang
F
Che
Chi-Ming
CM
Wong
Catherine C L
CC
Abagyan
Ruben
R
Leung
Chung-Hang
CH
Ma
Dik-Lung
DL
D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology*; D055808:Drug Discovery; D006801:Humans; D008958:Models, Molecular; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D001688:Biological Products; D014409:Tumor Necrosis Factor-alpha