Association between polymorphisms of matrix metalloproteinase 11 (MMP-11) and Kawasaki disease in the Korean population.
OBJECTIVE
This study was conducted to investigate the associations between single nucleotide polymorphisms (SNPs) of matrix metalloproteinases (MMPs) and Kawasaki disease (KD) in the Korean population.


METHODS
A total 0f 101 KD patients and 306 healthy controls were examined. MMP7 (rs10502001, G/A, Arg77His), MMP11 (rs738792, T/C, Ala38Val), MMP12 (rs652438, A/G, Ile357Val) and MMP26 (rs2499953, A/G, Lys43Glu) genes were genotyped from the genomic DNA using direct sequencing. The results were then analyzed using logistic regression models, adjusting for gender as covariates.


RESULTS
The four SNPs were in Hardy-Weinberg equilibrium. Only the MMP11 polymorphism (rs738792) was associated with KD. The SNP (rs738792) showed a statistically significant association with KD in the codominant (OR=1.61, 95% CI=1.11-2.34, P=0.011) and dominant (OR=1.92, 95% CI=1.21-3.06, P=0.006) models. However, there was no association between polymorphisms of other MMP genes and KD.


CONCLUSIONS
Overall, the results of this study indicate that MMP11 polymorphism may be associated with KD in the Korean population.
College of Dentistry and Institute of Tissue Regeneration Engineering, Dankook University, Cheonan, Republic of Korea.
Ju Yeon
JY
Ban
Su Kang
SK
Kim
Sung Wook
SW
Kang
Kyung Lim
KL
Yoon
Joo-Ho
JH
Chung
D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D007723:Korea; D016015:Logistic Models; D008297:Male; D053507:Matrix Metalloproteinase 11 / Q000235:genetics*; D020782:Matrix Metalloproteinases / Q000235:genetics*; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
D053507:Matrix Metalloproteinase 11; D020782:Matrix Metalloproteinases