Supraselective injection of intraarterial melphalan as the primary treatment for late presentation unilateral multifocal stage Vb retinoblastoma.
OBJECTIVE
The purpose of this study was to report a case of a 7-year-old girl with unilateral, multifocal Reese Ellsworth Stage Vb retinoblastoma who was successfully treated using intraarterial chemotherapy infusion as the primary therapy.


METHODS
This is an interventional case report. A 7-year-old girl presented with advanced unilateral retinoblastoma. The patient received intraarterial melphalan infusion therapy as the primary treatment.


RESULTS
Complete tumor resolution was seen at 1 month after intraarterial melphalan infusion.


CONCLUSIONS
This case of advanced retinoblastoma in a 7-year-old girl was successfully treated with intraarterial melphalan infusion alone. Treatment resulted in complete resolution of the tumor 1 month after treatment. In comparison with systemic chemotherapy, intraarterial melphalan infusion therapy may be a less toxic and more effective primary treatment option in the future management of advanced retinoblastoma.
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Hassan A
HA
Aziz
Hinda
H
Boutrid
Timothy G
TG
Murray
Audina
A
Berrocal
Stacey Quintero
SQ
Wolfe
Yolanda
Y
Pina
Mark
M
Dorfman
Roham
R
Moftakhar
Cristina E
CE
Fernandes
Jennifer
J
Reichbach
Mohammad Ali
MA
Aziz-Sultan
D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D002648:Child; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008558:Melphalan / Q000008:administration & dosage*; D009367:Neoplasm Staging; D012074:Remission Induction; D019572:Retinal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D012175:Retinoblastoma / Q000188:drug therapy* / Q000473:pathology; D014792:Visual Acuity
D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan