High-flow nasal cannula and extubation success in the premature infant: a comparison of two modalities.
OBJECTIVE
To compare the effectiveness of Fisher and Paykel (FP) and Vapotherm (VT) high-flow nasal cannula (HFNC) in preventing reintubation either within 72 h or <7 days after extubation of premature infants. The primary outcome was the rate of extubation failure defined as reintubation within 72 h. Secondary outcomes included reintubation after ≤7 days.


METHODS
This was a prospective, randomized pilot study comparing the extubation success of 40 infants born between 26 and 29 weeks of gestation.


RESULTS
The rate of extubation failure at 72 h was 18% for FP and 9% for VT. The failure rate ≤7 days after extubation was 30% for FP and 27% for VT. None of these differences were statistically significant.


CONCLUSIONS
There was no difference between FP and VT in the extubation success of infants born between 26 and 29 weeks.
Division of Newborn Medicine, Weill Cornell Medical College, New York, NY, USA.
S M
SM
Miller
S A
SA
Dowd
D002245:Carbon Dioxide / Q000097:blood; D045422:Continuous Positive Airway Pressure / Q000295:instrumentation*; D004867:Equipment Design; D005260:Female; D006612:High-Frequency Ventilation / Q000295:instrumentation*; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D007442:Intubation, Intratracheal / Q000295:instrumentation*; D008297:Male; D010100:Oxygen / Q000097:blood; D010865:Pilot Projects; D011446:Prospective Studies; D012127:Respiratory Distress Syndrome, Newborn / Q000628:therapy*; D012131:Respiratory Insufficiency / Q000628:therapy*; D015300:Ventilator Weaning
D002245:Carbon Dioxide; D010100:Oxygen