Case-control study to evaluate risk factors for the development of sepsis (neutropenia and fever) in dogs receiving chemotherapy.
OBJECTIVE-To identify risk factors for development of sepsis in dogs treated with chemotherapeutics and to evaluate the impact of sepsis on outcome. DESIGN-Case-control study. ANIMALS-Client-owned dogs with various cancers undergoing standard chemotherapeutic treatment at the University of Pennsylvania veterinary hospital. PROCEDURES-39 dogs with sepsis (cases) were identified through a search of the medical record database. Controls (n = 77) were randomly selected from dogs admitted during the same time period. Variables analyzed included patient demographics, tumor type, stage, remission status, treatment phase, chemotherapeutics used, and outcome. RESULTS-Dogs that weighed less and dogs with lymphoma were significantly more likely to become septic, compared with larger dogs or dogs with solid tumors. Septic dogs were also significantly more likely to have received doxorubicin (odds ratio [OR], 12.5; 95% confidence interval [CI], 2.4 to 66.0) or vincristine (OR, 9.0; 95% CI, 1.6 to 52.0) than controls. Of the 39 cases, 28 (71.8%) were in the induction phase of their protocol, and 19 of 39 (48.7%) became septic after receiving the chemotherapeutic drug for the first time. Median survival time of the cases (253 days) was not significantly different from that of the controls (371 days). CONCLUSIONS AND CLINICAL RELEVANCE-Dogs that weighed less were at increased risk for chemotherapy-induced sepsis. Tumor type and chemotherapeutic drug used were also important risk factors. These results may lead to the implementation of prophylactic measures, especially when doxorubicin or vincristine is used in the induction phase in small dogs with lymphoma.
Department of Clinical Studies, School of Veterinary Medicine, Philadelphia, PA 19104, Mari Lowe Center for Comparative Oncology, School of Veterinary Medicine, Philadelphia, PA 19104, USA. karins@vet.upenn.edu
Karin U
KU
Sorenmo
Lisa P
LP
Harwood
Lesley G
LG
King
Kenneth J
KJ
Drobatz
D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001835:Body Weight; D016022:Case-Control Studies; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D005260:Female; D005334:Fever / Q000209:etiology / Q000662:veterinary*; D008297:Male; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy / Q000662:veterinary*; D009503:Neutropenia / Q000209:etiology / Q000662:veterinary*; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000209:etiology / Q000662:veterinary*
D000970:Antineoplastic Agents