Periprocedural bridging anticoagulation: current perspectives.
Perioperative management of patients on chronic anticoagulant use involves balancing individual risk for thromboembolism and bleeding. Discontinuation of antithrombotic therapy can place patients at increased risk of thromboembolic complications, whereas continuing antithrombotic therapy can increase procedure-related bleeding risk. Temporary perioperative substitution of low-molecular weight heparin or unfractionated heparin in place of warfarin, "the bridge therapy" is often used in the periprocedural period, but the indications and timing of this is still uncertain. This review addresses the risk stratification of patients according to thromboembolic risk, indications, timing, and duration, and a practical approach to bridge therapy.
Department of Medicine, New York Medical College, Valhalla, NY 10595, USA. drpchandrasekar@gmail.com
Chandrasekar
C
Palaniswamy
Dhana R
DR
Selvaraj
D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D016063:Blood Loss, Surgical / Q000517:prevention & control; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D019990:Perioperative Care / Q000379:methods*; D019106:Postoperative Hemorrhage / Q000517:prevention & control*; D018570:Risk Assessment; D013923:Thromboembolism / Q000517:prevention & control*; D014859:Warfarin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D000925:Anticoagulants; D014859:Warfarin; D006493:Heparin