Achieving asthma control in the inner city: do the National Institutes of Health Asthma Guidelines really work?
For children living in inner cities, asthma tends to be more frequent and severe. To characterize, understand, and treat children with asthma living in the inner city more effectively, the National Institute of Allergy and Infectious Diseases established an Inner-City Asthma Program in 1991. In addition, the revised National Asthma Education and Prevention Program Expert Panel 3 report was introduced with new concepts for asthma management that are now centered on asthma control. The purpose of this review is to highlight features of the National Institute of Allergy and Infectious Diseases Inner-City Asthma Consortium Asthma Control Evaluation study that enhance our knowledge regarding the application of the asthma guidelines and to provide a summary of lessons learned from that important study. We recognized that asthma symptoms and exacerbations are theoretically linked to underlying inflammation of airways but are not direct indicators of inflammation. Based on the observations from the Asthma Control Evaluation study, we were impressed that a systematic guidelines-based approach improved asthma control significantly over the course of the 1-year treatment period.
Divisions of Pediatric Clinical Pharmacology and Allergy and Immunology, Department of Pediatrics, National Jewish Health, University of Colorado Denver School of Medicine, Denver, Colo., USA. szeflers@njhealth.org
Stanley J
SJ
Szefler
Peter J
PJ
Gergen
Herman
H
Mitchell
Wayne
W
Morgan
D000293:Adolescent; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D002648:Child; D006801:Humans; D055118:Medication Adherence; D015337:Multicenter Studies as Topic; D009316:National Institutes of Health (U.S.); D017410:Practice Guidelines as Topic; D016032:Randomized Controlled Trials as Topic; D014481:United States; D014505:Urban Population; D055815:Young Adult
D018927:Anti-Asthmatic Agents