Somatic cell nuclear transfer: pros and cons.
Even though the technique of mammalian SCNT is just over a decade old it has already resulted in numerous significant advances. Despite the recent advances in the reprogramming field, SCNT remains the bench-mark for the generation of both genetically unmodified autologous pluripotent stem cells for transplantation and for the production of cloned animals. In this review we will discuss the pros and cons of SCNT, drawing comparisons with other reprogramming methods.
Sumer
Huseyin
H
Monash Institute of Medical Research, Monash University, 27-31 Wright Street, Clayton VIC 3168, Australia.
Liu
Jun
J
Tat
Pollyanna
P
Heffernan
Corey
C
Jones
Karen L
KL
Verma
Paul J
PJ
D000818:Animals; D019976:Cloning, Organism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology / Q000637:transplantation; D053652:Nuclear Transfer Techniques / Q000009:adverse effects; D039904:Pluripotent Stem Cells / Q000502:physiology / Q000637:transplantation; D018570:Risk Assessment