First case of genotype 4 human hepatitis E virus infection acquired in India.
This report describes a case of severe hepatitis in an individual returning from India which was found to be the result of infection with HEV genotype 4. HEV was diagnosed using a novel RT-PCR assay (with internal control) for HEV RNA detection/quantitation, described herein. This is the first documented report of zoonotic transmission of HEV genotype 4 infection acquired in India.
Clinical Microbiology and Public Health Laboratory, Health Protection Agency, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QW, UK. Kathryn.rolfe@addenbrookes.nhs.uk
K J
KJ
Rolfe
M D
MD
Curran
N
N
Mangrolia
W
W
Gelson
G J M
GJ
Alexander
M
M
L'estrange
R
R
Vivek
R
R
Tedder
S
S
Ijaz
D000368:Aged; D000818:Animals; D005838:Genotype; D016751:Hepatitis E / Q000821:virology*; D016752:Hepatitis E virus / Q000235:genetics*; D006801:Humans; D007194:India; D008111:Liver Function Tests; D008297:Male; D010802:Phylogeny; D012367:RNA, Viral / Q000097:blood; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013552:Swine; D015047:Zoonoses / Q000821:virology*
D012367:RNA, Viral