[Physiopathological progress in type 1 diabetes].
Type 1 diabetes results from the autoimmune destruction of pancreatic islet B cells, leading within various times to absolute insulin deficiency. The pathophysiology of the disease remains partly unclear: only half of the genetic predisposition is known; the nature, and even the reality, of a triggering event in the autoimmune activation are not established; furthermore, the primitive target of the autoimmune process is not fully determined. As immunological markers of the disease have been developped, therapeutic perspectives for type 1 diabetes prevention have emerged. However, little have been sucessful until now, reflecting the disease heterogeneity and complexity and the difficulty to define the best therapeutic window.
Service d'immunologie clinique (Pr Boitard), hôpital Cochin, 75679 Paris Cedex 14. daniele.dubois@cch.aphp.fr
Danièle
D
Dubois-Laforgue
D003922:Diabetes Mellitus, Type 1 / Q000209:etiology / Q000276:immunology / Q000503:physiopathology*; D006801:Humans
Progrès physiopathologiques dans le diabète de type 1.