Cytoglobosins A-G, cytochalasans from a marine-derived endophytic fungus, Chaetomium globosum QEN-14.
Cytoglobosins A-G (1-7), seven new cytochalasan derivatives, along with two structurally related known compounds, isochaetoglobosin D (8) and chaetoglobosin F(ex) (9), were isolated and identified from the cultures of Chaetomium globosum QEN-14, an endophytic fungus derived from the marine green alga Ulva pertusa. The structures of the new natural products as well as their relative configurations were elucidated on the basis of 1D and 2D NMR spectra (COSY, HSQC, HMBC, and NOESY) and HRESIMS data. Cytoglobosins C and D (3 and 4) displayed cytotoxic activity against the A-549 tumor cell line.
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, People's Republic of China.
Chuan-Ming
CM
Cui
Xiao-Ming
XM
Li
Chun-Shun
CS
Li
Peter
P
Proksch
Bin-Gui
BG
Wang
D000818:Animals; D002597:Chaetomium / Q000737:chemistry; D000460:Chlorophyta / Q000382:microbiology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007624:KB Cells; D007941:Leukemia P388; D008386:Marine Biology; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
D026121:Indole Alkaloids; C019290:chaetoglobosins