[Progress on X-linked mental retardation related gene JARID1C].
JARID1C is one of the genes related to X-linked mental retardation. Its express product influences transcription and expression of the related genes in brain nervous system, and may be associated with human cognitive ability. Study on the functions of JARID1C not only helps to understand its molecular role in mental retardation and human cognitive ability, but also provides references for clinical diagnosis and prevention of mental retardation. This article reviews the progresses on JARID1C in location, isolation, physiological functions, and cognitive functions of its encoding product. The future re-search work of JARID1C is also discussed.
Lei
Xu
X
Institute of Population and Health, College of Life Science, Northwest University, Xi'an 710069, China. leixu840806@163.com
Gao
Xiao-Cai
XC
Zhang
Fu-Chang
FC
D003071:Cognition / Q000502:physiology; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D038901:X-Linked Intellectual Disability / Q000235:genetics*; D009154:Mutation