Classification of cerebellar atrophy using voxel-based morphometry and SPECT with an easy Z-score imaging system.
OBJECTIVE
With conventional MRI and single-photon emission computed tomography (SPECT), accurate diagnosis and precise classification of cerebellar atrophy are often difficult. The objective was to verify the utility of MRI voxel-based morphometry (VBM) in combination with SPECT using easy Z-score imaging (eZIS) for diagnosing and classifying cerebellar atrophy.


METHODS
We assessed gray matter atrophy using VBM and blood perfusion using SPECT with eZIS in fifteen patients with different types of cerebellar atrophy, such as the cerebellar variant of multiple system atrophy (MSA-C), spinocerebellar ataxia type 3 (SCA3), SCA6, and autoimmune cerebellar ataxia (AICA).


RESULTS
In all five MSA-C patients, VBM imaging showed atrophy of the brainstem, the entire cerebellar vermis, and the cerebellar hemispheres, while SPECT using eZIS showed reduced perfusion in the same regions. Regarding SCA3, brainstem atrophy and reduced perfusion were recognized in two of the four patients, but none exhibited abnormal findings in the posterior lobe of the cerebellar vermis. SPECT showed that all four patients had obviously reduced perfusion in the anterior lobe of the vermis, but VBM demonstrated that there was no obvious atrophy of gray matter in any patient, meaning that the results of SPECT and VBM contradicted each other completely. All SCA6 and AICA patients exhibited atrophy and reduced perfusion in the cerebellar hemispheres but not in the brainstem. Only one AICA patient exhibited atrophy and reduced perfusion of the entire cerebellar vermis.


CONCLUSIONS
VBM clearly showed characteristic gray matter atrophy in the cerebellum and brainstem in different pathological conditions, thus indicating its high degree of utility in diagnosing and classifying cerebellar atrophy in combination with SPECT using eZIS.
Nanri
Kazunori
K
Department of Neurology, Tokyo Medical University Hachioji Medical Center. synapse@tokyo-med.ac.jp
Koizumi
Kiyoshi
K
Mitoma
Hiroshi
H
Taguchi
Takeshi
T
Takeguchi
Masafumi
M
Ishiko
Tomoko
T
Otsuka
Takao
T
Nishioka
Hiroshi
H
Mizusawa
Hidehiro
H
D001284:Atrophy / Q000000981:diagnostic imaging / Q000473:pathology; D001933:Brain Stem / Q000000981:diagnostic imaging / Q000473:pathology; D002524:Cerebellar Ataxia / Q000000981:diagnostic imaging / Q000473:pathology; D002526:Cerebellar Diseases / Q000145:classification* / Q000000981:diagnostic imaging*; D002531:Cerebellum / Q000000981:diagnostic imaging* / Q000473:pathology*; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D020754:Spinocerebellar Ataxias / Q000000981:diagnostic imaging / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*