Percentages of CD4+ T regulatory cells and HLA-DR expressing monocytes in severe intra-abdominal infections.
To study the immune status of patients with severe abdominal infections, we assayed percentages of CD4+ T regulatory cells (CD4+CD25+FOXP3+ Treg) and human leukocyte antigen DR (HLA-DR) expressing CD14+ cells in peripheral blood. A total of 46 subjects with varying acute physiology and chronic health evaluation II (APACHE II) scores were included in the study. There was a significant (p < 0.01) increase in the percentage of CD4+CD25+FOXP3+ Treg and a significant (p < 0.01) decrease in HLA-DR expressing CD14+ cells with increasing APACHE II score. Such modifications may contribute to the aggravation of severe intra-abdominal infections.
Department of Surgery, Tianjin Medical University, Nankai Hospital, Nankai District, Tianjin, China. fq@medmail.com.cn
Qiang
Q
Fu
Naiqiang
N
Cui
Wenli
W
Yu
Chao
C
Du
D018806:APACHE; D034841:Abdominal Cavity / Q000503:physiopathology*; D000368:Aged; D000704:Analysis of Variance; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006684:HLA-DR Antigens / Q000378:metabolism*; D006801:Humans; D007239:Infections / Q000378:metabolism*; D053645:Interleukin-2 Receptor alpha Subunit / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism; D018805:Sepsis / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000378:metabolism
C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D006684:HLA-DR Antigens; C508017:IL2RA protein, human; D053645:Interleukin-2 Receptor alpha Subunit