Amelioration of STZ-induced type 1 diabetic nephropathy by aqueous extract of Enicostemma littorale Blume and swertiamarin in rats.
Diabetic nephropathy (DN) is one of the foremost causes of renal failure and a primary cause of diabetes mellitus related death. Previously, we have reported that aqueous extract of Enicostemma littorale has potential antidiabetic activity. In the present study, we have investigated the effect of aqueous extract of E. littorale 1 g/kg, p.o. and swertiamarin 50 mg/kg, p.o. daily for 3 weeks in type 1 DN complications in SD rats. DN was assessed by serum urea, creatinine, lipid profile and water intake levels. Treatment with aqueous extract of E. littorale and swertiamarin significantly decreased serum urea and creatinine and other parameters associated with the development of DN in type 1 diabetic rats. We have also found considerable improvement in histology of glomerular function of aqueous extract of E. littorale and swertiamarin-treated animals.
Department of Pharmacology, L.M. College of Pharmacy, P.O. Box 4011, Navrangpura, Ahmedabad 380 009, India.
Rakesh D
RD
Sonawane
Santosh L
SL
Vishwakarma
S
S
Lakshmi
Mandapati
M
Rajani
Harish
H
Padh
Ramesh K
RK
Goyal
D000284:Administration, Oral; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D003928:Diabetic Nephropathies / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004326:Drinking / Q000187:drug effects; D029965:Gentianaceae; D005960:Glucosides / Q000008:administration & dosage / Q000494:pharmacology*; D006984:Hypertrophy; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D057888:Iridoid Glucosides; D039823:Iridoids / Q000008:administration & dosage / Q000494:pharmacology*; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D008055:Lipids / Q000097:blood; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011753:Pyrones / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014508:Urea / Q000097:blood
D015415:Biomarkers; D001786:Blood Glucose; D005960:Glucosides; D007004:Hypoglycemic Agents; D057888:Iridoid Glucosides; D039823:Iridoids; D008055:Lipids; D010936:Plant Extracts; D011753:Pyrones; C013270:swertiamarin; D014508:Urea; D003404:Creatinine