Electro-spinning of PLGA/PCL blends for tissue engineering and their biocompatibility.
In this study, an electro-spun co-polymer PLGA/PCL blend was fabricated using various percentages of PLGA in the blend PLGA/PCL solutions. The PLGA/PCL ratios used to fabricate the electrospun fibrous mats were reflected in the FT-IR (Fourier Transform Infrared Spectroscopy) data. Experimental results from the MTT assay showed that the biocompatibility of the electro-spun co-polymer increased at increasing percentages of PLGA. In vitro cells adhesion and proliferation of fibroblast cells on electro-spun mats were characterized by SEM morphology. In addition, we found that increasing PLGA concentrations affected the mechanical properties of electro-spun membranes and increased the biocompatibility of PLGA/PCL electro-spun fibrous mats.
Hiep
Nguyen Thi
NT
Department of Biomedical Engineering and Materials, College of Medicine, Soonchunhyang University, Cheonan 330-090, Korea.
Lee
Byong-Taek
BT
D000818:Animals; D002448:Cell Adhesion; D005347:Fibroblasts / Q000166:cytology; D007739:L Cells; D019344:Lactic Acid; D051379:Mice; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering / Q000379:methods*
D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid