[Expression and significance of CK7 and CK19 in colon cancer].
OBJECTIVE
To detect the cytokeratin (CK) genes expression in the colon cancer, and investigate the expression variability in different pathological types and clinical stages.


METHODS
The CK gene expression pattern in normal colon, colon cancer tissues and colon cancer cell lines were analyzed by using Immunohistochemical, Immunocytochemical and Western blot ways.


RESULTS
CK7 and CK19 didn't express in normal colon tissues. CK7 was low or not expressed in the colon cancer, and CK19 was highly expressed in the colon cancer. There were significant deviation (P<0.05).


CONCLUSIONS
CK7 and CK19 may be correlated with the carcinogenesis of colon cancer, and CK7-)/CK19+ may be one of the expression characteristics in colon cancer.
Department of Obstetrics and Gynecology, Medical School, Xi'an Jiaotong University, Key Laboratory of Environment and Genes Related to Diseases, Ministry of Education, Xi'an, China. zhang_xin101@yahoo.com.cn
Xin
X
Zhang
Peng-sheng
PS
Zheng
D000328:Adult; D000368:Aged; D003106:Colon / Q000737:chemistry; D003110:Colonic Neoplasms / Q000737:chemistry* / Q000473:pathology; D019073:HT29 Cells; D006801:Humans; D007150:Immunohistochemistry; D053539:Keratin-19 / Q000032:analysis*; D053552:Keratin-7 / Q000032:analysis*; D008875:Middle Aged
C507497:KRT7 protein, human; D053539:Keratin-19; D053552:Keratin-7