The VIZIER project: overview; expectations; and achievements.
VIZIER is an acronym for a research project entitled "Comparative Structural Genomics of Viral Enzymes Involved in Replication" funded by the European Commission between November 1st, 2004 and April 30th, 2009. It involved 25 partners from 12 countries. In this paper, we describe the organization of the project and the culture created by its multidisciplinary essence. We discuss the main thematic sections of the project and the strategy adopted to optimize the integration of various scientific fields into a common objective: to obtain crystal structures of the widest variety of RNA virus replication enzymes documented and validated as potential drug targets. We discuss the thematic sections and their overall organization, their successes and bottlenecks around the protein production pipeline, the "low hanging fruit" strategy, and measures directed to problem solving. We discuss possible future options for such large-scale projects in the area of antiviral drug design. In a series of accompanying papers in Antiviral Research, the project and its achievements are presented for each virus family.
Coutard
Bruno
B
Laboratoire Architecture et Fonction des Macromolécules Biologiques, CNRS UMR-6098, Universités Aix-Marseille I et II, ESIL Case 925, 163 Avenue de Luminy, 13288 Marseille, France.
Canard
Bruno
B
D000818:Animals; D018360:Crystallography, X-Ray; D004798:Enzymes / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D005062:European Union; D023281:Genomics / Q000379:methods* / Q000639:trends; D006801:Humans; D012328:RNA Viruses / Q000201:enzymology* / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D014779:Virus Replication
D004798:Enzymes; D014764:Viral Proteins