Angiogenic activity of Synadenium umbellatum Pax latex.
Synadenium umbellatum Pax, popularly known as 'cola-nota', is a medicinal plant that grows in tropical regions. Latex of this plant is used to treat various diseases such as diabetes mellitus, Hansen s disease, tripanosomiases, leukemia and several malignant tumors. In the present study, the angiogenic activity of S. umbellatum latex was evaluated using the chick embryo chorioallantoic membrane (CAM) assay. Results showed significant increase of the vascular net (p < 0.05) compared to the negative control (H2O). The histological analysis was in accordance with the results obtained. In conclusion, our data indicate that S. umbellatum latex, under the conditions of this research, presented angiogenic effect.
Melo-Reis
P R
PR
Departamento de Biomedicina, Laboratório de Estudos Experimentais e Biotecnológicos, Pontifícia Universidade Católica de Goiás, Goiânia, GO, Brazil.
Andrade
L S
LS
Silva
C B
CB
Araújo
L M M
LM
Pereira
M S
MS
Mrue
F
F
Chen-Chen
L
L
D000818:Animals; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000187:drug effects*; D019665:Euphorbiaceae / Q000737:chemistry*; D007840:Latex / Q000494:pharmacology*; D018919:Neovascularization, Physiologic / Q000187:drug effects* / Q000502:physiology
D007840:Latex