Bupropion toxicokinetic: a case report.
BACKGROUND
The toxicokinetics of sustained-release bupropion are not well described.


METHODS
A 23-year-old Caucasian male took an overdose of 5,700 mg of sustained release bupropion with no co-ingestant. Venous serum samples were assayed for bupropion concentrations over the next 5 days. The peak concentration was 1.114 mg/L. The observed T(max) was found to be 8.25 h, the calculated alpha half-life 10.9 h (+/-SE of 4.47%), and the calculated beta half-life 19.8 h (+/-SE 12.62%). The alpha half-life and T(max) differ significantly from those seen in therapeutic doses.


CONCLUSIONS
Bezoar formation may underlie these differences. Interventions which reduce the absorption of sustained release bupropion may be effective in overdose.
Department of Anaesthetics, UHB NHS Trust, Sellyoak, Birmingham, UK. kdonnelly2@nhs.net <kdonnelly2@nhs.net>
Kieran
K
Donnelly
Hannah Beth
HB
Walkowiak
Christopher
C
Donnelly
Emma
E
Jenkinson
Jonha
J
Rizkalla
Nigel
N
Langford
D000328:Adult; D000928:Antidepressive Agents / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D016642:Bupropion / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D003692:Delayed-Action Preparations / Q000493:pharmacokinetics / Q000506:poisoning; D062787:Drug Overdose / Q000097:blood; D006801:Humans; D008297:Male
D000928:Antidepressive Agents; D003692:Delayed-Action Preparations; D016642:Bupropion