Exogenous insulin enhances humoural immune responses in short-day, but not long-day, Siberian hamsters (Phodopus sungorus).
Many animals experience marked seasonal fluctuations in environmental conditions. In response, animals display adaptive alterations in physiology and behaviour, including seasonal changes in immune function. During winter, animals must reallocate finite energy stores from relatively costly, less exigent systems (e.g. reproduction and immunity) to systems critical for immediate survival (e.g. thermoregulation). Seasonal changes in immunity are probably mediated by neuroendocrine factors signalling current energetic state. One potential hormonal candidate is insulin, a metabolic hormone released in response to elevated blood glucose levels. The aim of the present study was to explore the potential role of insulin in signalling energy status to the immune system in a seasonally breeding animal, the Siberian hamster (Phodopus sungorus). Specifically, exogenous insulin was administered to male hamsters housed in either long 'summer-like' or short 'winter-like' days. Animals were then challenged with an innocuous antigen and immune responses were measured. Insulin treatment significantly enhanced humoural immune responses in short, but not long days. In addition, insulin treatment increased food intake and decreased blood glucose levels across photoperiodic treatments. Collectively, these data support the hypothesis that insulin acts as an endocrine signal integrating seasonal energetic changes and immune responses in seasonally breeding rodents.
Department of Biology, Program in Neuroscience and Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN 47405, USA.
Nicholas W
NW
Garcia
Timothy J
TJ
Greives
Devin A
DA
Zysling
Susannah S
SS
French
Emily M
EM
Chester
Gregory E
GE
Demas
D000222:Adaptation, Physiological / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D001786:Blood Glucose; D006224:Cricetinae; D004797:Enzyme-Linked Immunosorbent Assay; D056724:Immunity, Humoral / Q000187:drug effects*; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D020738:Leptin / Q000097:blood; D008297:Male; D017111:Phodopus / Q000276:immunology*; D017440:Photoperiod; D012621:Seasons
D001786:Blood Glucose; D007328:Insulin; D020738:Leptin