Formal synthesis of (+)-nakadomarin A.
The formal synthesis of (+)-nakadomarin A was completed. The significant points of this synthesis are the highly stereoselective formation of the diazatricyclo[6.4.0.0(1,5)]dodecane skeleton (A, B, and D rings) based on the Pauson-Khand reaction and novel furan ring (C ring) formation, using the vinyl residue of the Pauson-Khand product.
Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan.
Fuyuhiko
F
Inagaki
Masahiko
M
Kinebuchi
Naoki
N
Miyakoshi
Chisato
C
Mukai
D000473:Alkanes / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry; D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
D000473:Alkanes; D000890:Anti-Infective Agents; D002243:Carbolines; C476640:nakadomarin A; C007548:n-dodecane