Prolonged maternal magnesium administration and bone metabolism in neonates.
BACKGROUND
Magnesium sulfate (MgSO(4)) has been used as a tocolytic agent in cases of refractory preterm labor. Prolonged maternal administration of MgSO(4) may induce bone demineralization in the neonate. However, the effects of MgSO(4) on serum biochemistry related to bone metabolism in neonates remain unclear.


OBJECTIVE
To assess the effects of prolonged maternal administration of MgSO(4) on fetuses and neonates.


METHODS
This retrospective case-control study examined 167 neonates. Cases comprised 58 neonates whose mothers had received intravenous MgSO(4) administration for >5 days. Neonatal serum levels of magnesium (Mg), calcium (Ca), phosphorus (P) and alkaline phosphatase (ALP) were reviewed. We also investigated whether subject neonates showed appearance of osteopenia at the metaphyseal lines on radiography at birth.


RESULTS
Mean serum Mg and P levels were significantly higher, and Ca levels were significantly lower, in cases than in controls at birth. Mean serum ALP level was 1188.5IU/l in cases, significantly higher than that in controls at birth. Bone abnormalities were noted on radiography in 2 subjects. By 3 weeks old, serum ALP levels did not differ significantly between cases and controls. Logistic regression analysis revealed maternal administration of MgSO(4) and multiple pregnancies were significantly related to serum ALP level in neonates at birth.


CONCLUSIONS
Prolonged maternal administration of MgSO(4) significantly affects neonatal serum biochemistry related to bone metabolism. Potential long-term adverse effects on neonates and how Mg affects fetal bone metabolism in utero need to be investigated in future studies.
Department of Pediatrics, Jichi Medical University School of Medicine, 3311-1 Yakushiji, Shimotsuke, Tochigi, Japan.
Koji
K
Yokoyama
Naoto
N
Takahashi
Yukari
Y
Yada
Yasunori
Y
Koike
Ryou
R
Kawamata
Ritei
R
Uehara
Yumi
Y
Kono
Yoko
Y
Honma
Mariko Y
MY
Momoi
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D001724:Birth Weight / Q000502:physiology; D018488:Bone Demineralization, Pathologic / Q000139:chemically induced*; D015519:Bone Density / Q000187:drug effects; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D016015:Logistic Models; D008278:Magnesium Sulfate / Q000008:administration & dosage* / Q000009:adverse effects* / Q000097:blood; D010758:Phosphorus / Q000097:blood; D011247:Pregnancy; D011859:Radiography; D012189:Retrospective Studies
D010758:Phosphorus; D008278:Magnesium Sulfate; D000469:Alkaline Phosphatase; D002118:Calcium