Antagonism between cadmium and magnesium: a possible role of magnesium in therapy of cadmium intoxication.
One of the important mechanisms of cadmium (Cd) toxicity is its interactions with bioelements, including magnesium (Mg). Exposure to Cd leads to disturbances in Mg metabolism in the organism, while Mg supplementation has an adverse effect on Cd absorption, accumulation and toxicity. According to the available results, which indicate a protective role of Mg against Cd toxicity, it remains to be seen whether magnesium may influence the important unsolved problem of Cd intoxication therapy. In this review, the interactions between the toxic metal Cd and the bioelement Mg are discussed on the basis of the available literature and our own results. We discuss these interactions mainly based on experimental data because data from human studies are scarce.
Institute of Toxicology Academic Danilo Soldatović, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia. vevodi@pharmacy.bg.ac.rs
Vesna
V
Matović
Zorica
Z
Plamenac Bulat
Danijela
D
Djukić-Cosić
Danilo
D
Soldatović
D000818:Animals; D002104:Cadmium / Q000378:metabolism* / Q000633:toxicity*; D002105:Cadmium Poisoning / Q000188:drug therapy / Q000378:metabolism; D004347:Drug Interactions; D006801:Humans; D008274:Magnesium / Q000378:metabolism* / Q000627:therapeutic use*
D002104:Cadmium; D008274:Magnesium