Non-O1, non-O139 Vibrio cholerae bacteraemia in splenectomised thalassaemic patient from Malaysia.
Vibrio cholerae infection is mainly caused acute diarrhoea disease. Bacteraemia due to non-O1 V. cholerae is rare and mainly reported in liver cirrhotic patients. We report one case of non-O1 V. cholerae bacteraemia in splenectomised thalassaemic patient who presented with septic shock secondary to abdominal sepsis. She had undergone emergency laporatomy and was managed in the intensive care unit for nine days. She was treated with meropenem and doxycyline and discharged well after fourteen days of admission. The V. cholerae was identified by API 20NE, serotype and polymerase chain reaction showed as non-O1, non-O139 strain. Besides known cholera-like toxin and El Tor hemolysin, with increasing reported cases of V. cholerae bacteraemia, there is possibility of other virulence factors that allow this organism to invade the bloodstream.
Department of Medical Microbiology and Parasitology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, 16150 Kubang Kerian, Kelantan, Malaysia. zakuan@kb.usm.my
Z Z
ZZ
Deris
V M
VM
Leow
W M N
WM
Wan Hassan
N A Z
NA
Nik Lah
S Y
SY
Lee
H
H
Siti Hawa
H
H
Siti Asma
M
M
Ravichandran
D000005:Abdomen; D000328:Adult; D016470:Bacteremia / Q000150:complications / Q000382:microbiology*; D002763:Cholecystectomy; D004269:DNA, Bacterial / Q000235:genetics; D005260:Female; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D008296:Malaysia; D016133:Polymerase Chain Reaction; D012703:Serotyping; D012772:Shock, Septic / Q000150:complications / Q000382:microbiology*; D013156:Splenectomy; D013789:Thalassemia / Q000150:complications*; D014735:Vibrio Infections / Q000150:complications / Q000382:microbiology*; D044163:Vibrio cholerae non-O1 / Q000145:classification / Q000235:genetics / Q000302:isolation & purification / Q000472:pathogenicity; D037521:Virulence Factors / Q000235:genetics
D004269:DNA, Bacterial; D037521:Virulence Factors