Does donor race still make a difference in deceased-donor African-American renal allograft recipients?
BACKGROUND
Prior studies have demonstrated that African-American (AA) donor kidneys are independently associated with an increased risk for graft loss.


METHODS
We examined outcomes in comparable groups of AA deceased-donor (DD) kidney transplant patients receiving an AA donor (n=35) versus a Caucasian donor (C group; n=150) organ.


RESULTS
There were no differences between AA and C groups in patient survival, new-onset diabetes, or BK nephropathy. The AA group demonstrated a significantly higher 6-month and overall incidence of acute rejection (AR), increased cytomegalovirus (CMV) infection, and decreased graft survival. Recurrent or de novo focal segmental glomerulosclerosis (FSGS) accounted for a significantly higher fraction of graft losses in the AA versus C group.


CONCLUSIONS
AA DD renal allograft recipients have equivalent patient but decreased graft survival when transplanted with an AA versus C kidney using current immunosuppression. This may be the result of increased AR, CMV infection, and recurrence/development of FSGS.
Section of Transplant Surgery, Department of Surgery, Wayne State University School of Medicine, and Pharmacy Department, Harper University Hospital, Detroit, MI, USA.
Kristian L
KL
Brown
Mona D
MD
Doshi
Atul
A
Singh
Kalyani
K
Mehta
Katherina
K
Morawski
Elizabeth
E
Cincotta
Miguel S
MS
West
Scott A
SA
Gruber
D000328:Adult; D001741:Black or African American; D005260:Female; D006084:Graft Rejection / Q000453:epidemiology; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D014019:Tissue Donors; D044465:White People