How does intramolecular epitope spreading occur in BPAG2 (BP180)?
Several studies have suggested that autoantibodies directed against multiple epitopes occur via epitope spreading in autoimmune bullous skin diseases. However, the precise sequence of events in epitope spreading has not been elucidated for any of the epidermal autoantigens. In this issue, using a transgenic mouse model, Di Zenzo et al. report that intramolecular epitope spreading does occur for human BPAG2.
Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan. hashmot@med.kurume-u.ac.jp
Takashi
T
Hashimoto
Takahiro
T
Hamada
Teruki
T
Dainichi
Norito
N
Ishii
Tadashi
T
Karashima
Takekuni
T
Nakama
Shinichiro
S
Yasumoto
D000818:Animals; D001324:Autoantigens / Q000235:genetics* / Q000276:immunology*; D000939:Epitopes / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D024041:Non-Fibrillar Collagens / Q000235:genetics* / Q000276:immunology*; D000097805:Collagen Type XVII
D001324:Autoantigens; D000939:Epitopes; D024041:Non-Fibrillar Collagens; D000097805:Collagen Type XVII