[Role of histamine in atherosclerotic lesions].
Histamine is synthesized from L-histidine by histidine decarboxylase and is involved in a variety of physiologic responses, such as inflammation, type I allergy, gastric acid secretion and neurotransmission. In the arteriosclerotic lesions, histamine produced by macrophage-derived foam cells acts on smooth muscle cells, endocrine cells and inflammation cells through the specific histamine receptors and regulates the expression of many molecules concerned with inflammatory reaction. A regulatory system of chronic inflammatory reaction by the histamine network is involved in the formation and development of arteriosclerosis.
Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Japan.
Ke-Yong
KY
Wang
Akihide
A
Tanimoto
Yasuyuki
Y
Sasaguri
D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology*; D006632:Histamine / Q000502:physiology*; D006801:Humans
D006632:Histamine