Clinical pharmacokinetics and interaction of centchroman--a mini review.
This article provides a brief review of the information available regarding the published pharmacokinetics data for the nonsteroidal, once-a-week oral contraceptive, centchroman (INN: ormeloxifene). This agent is a unique need-oriented contraceptive agent which is included in the National Family Welfare Programme of India. Since 1991, centchroman has been used as a need-oriented contraceptive and is being given for treating dysfunctional bleeding of the uterus. Information regarding absorption, tissue distribution, elimination and kinetic interactions is discussed.
Lal
Jawahar
J
Pharmacokinetics and Metabolism Division, Central Drug Research Institute, CSIR, Lucknow, India. jlalcdri@rediffmail.com
D000818:Animals; D002486:Centchroman / Q000493:pharmacokinetics*; D003276:Contraceptives, Oral / Q000493:pharmacokinetics*; D003283:Contraceptives, Postcoital, Synthetic / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007194:India; D051381:Rats; D014592:Uterine Hemorrhage / Q000188:drug therapy
D003276:Contraceptives, Oral; D003283:Contraceptives, Postcoital, Synthetic; D002486:Centchroman