Absence of association between CD86 +1057G/A polymorphism and coronary artery disease.
CD86, one of the key costimulatory molecules, is not only involved in the initiation of T-cell immunity but also plays important roles in the development of cardiovascular diseases. The purpose of this study was to investigate the association between the CD86 polymorphism and the risk of coronary artery disease (CAD) in a Chinese population. We analyzed single-nucleotide polymorphism of CD86 +1057G/A (rs1129055) in 164 patients with CAD and 299 healthy controls by performing polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing assay. No significant association was observed in the genotype and allele frequencies of +1057G/A polymorphism between cases and controls, indicating that CD86 +1057G/A polymorphism may not be associated with CAD in the Chinese population.
Ma
Xiao-Na
XN
West China School of Preclinical and Forensic Medicine, West China Second University Hospital, Sichuan University, Chengdu, PR China.
Wang
Xia
X
Yan
You-Yi
YY
Yang
Lin
L
Zhang
Da-Lei
DL
Sheng
Xin
X
Liu
Xiao-Min
XM
Huang
Hong
H
Dai
Jing
J
Zhong
Ying-Jia
YJ
Liao
Lin-Chuan
LC
D051940:B7-2 Antigen / Q000235:genetics*; D003324:Coronary Artery Disease / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
D051940:B7-2 Antigen