Effect of low intensity continuous training programme on serum uric acid in the non pharmacological management of hypertension: a randomized controlled trial.
BACKGROUND
Elevated serum uric acid (SUA) is considered to be positively associated with cardiovascular event risk factor in hypertension. Also, the positive role of exercise in the management of Hypertension has been well and long established. However the relationship between SUA level and hypertensive management particularly in non pharmacological technique is ambiguous and unclear. Therefore the purpose of the present study was to determine the effect of continuous low intensity training programme on SUA level and cardiovascular parameters in male subjects with hypertension.


METHODS
Two hundred andseventeen male patients with mild to moderate (systolic blood pressure [SBP] between 140-180 & diastolic blood pressure [DBP] between 90-109 mmHg) essential hypertension were age matched and grouped into continuous and control groups. The continuous (n=112; 58.63 +/- 7.22 years) group involved in on 8 weeks interval training (35-9% HR max reserve) programme of between 45 minutes to 60 minutes, while age-matched controls hypertensive (n=105; 58.27 +/- 6.24 years) group remain sedentary during this period. Cardiovascular parameters (SBP, DBP & VO2max) and SUA were assessed. Students' t and Pearson correlation tests were used in data analysis.


RESULTS
Findings of the study revealed significant effect of interval training programme on VO2 max, SBP, and DBP and SUA concentration at p < 0.05 and changes in VO2max negatively correlated with SUA (r = -.266) at p < 0.05.


CONCLUSIONS
it was concluded that low intensity continuous training programme is an effective nonpharmacological management and may prevent cardiovascular event through the down regulation ofSUA in hypertension.
Physiotherapy/Physiology Dept., Faculty of Medical Sciences, Jimma University, Ethiopia. siklam_86@yahoo.co.uk
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D000368:Aged; D001794:Blood Pressure / Q000502:physiology*; D004311:Double-Blind Method; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid