Correlation between the interaction of the vinculin tail domain with lipid membranes, its phosphorylation and cell mechanical behaviour.
Cell adhesion and cell-cell contacts are a pre-requisite for proper metabolism, protein synthesis and cell survival. Integrins are the transmembrane receptors that link the extracellular matrix via the FAC (focal adhesion complex) with the cytoskeleton. Vinculin is a pivotal FAC protein that has not only been implicated in regulating FAC formation and transmitting mechanical forces, but also in associating with membranous lipids in biological systems.
Goldmann
Wolfgang H
WH
Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, Henkestrasse 91, 91052 Erlangen, Germany. wgoldmann@biomed.uni-erlangen.de
D002448:Cell Adhesion; D002462:Cell Membrane / Q000378:metabolism*; D003599:Cytoskeleton; D022001:Focal Adhesions; D016023:Integrins / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D016596:Vinculin / Q000737:chemistry / Q000378:metabolism*
D016023:Integrins; D008563:Membrane Lipids; D016596:Vinculin