Adult human mesenchymal cells proliferate and migrate in response to chemokines expressed in demyelination.
Systemic delivery of multipotent mesenchymal stem cells (MSC) may be of benefit in the treatment of neurological diseases, including multiple sclerosis (MS). Certainly, animal studies have demonstrated functional benefits following MSC transplantation, although the mechanisms by which MSCs migrate to lesions and stimulate repair remain unknown. Chemokines stimulate migration in other settings. In this study, we systematically explore the migratory and proliferative responses of human MSCs (hMSC) to chemokines expressed in MS lesions. We demonstrate that these chemokines trigger hMSC migration. In addition, we show that RANTES and IP-10 promote hMSC proliferation.
Institute of Clinical Neurosciences, University of Bristol, Frenchay Hospital, Bristol, UK. c.m.rice@bristol.ac.uk
Claire M
CM
Rice
Neil J
NJ
Scolding
D000328:Adult; D002448:Cell Adhesion; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D018932:Chemokine CCL2 / Q000494:pharmacology; D054405:Chemokine CCL3 / Q000494:pharmacology; D018946:Chemokine CCL5 / Q000494:pharmacology; D054357:Chemokine CXCL10 / Q000494:pharmacology; D054377:Chemokine CXCL12 / Q000494:pharmacology; D018925:Chemokines / Q000494:pharmacology*; D003711:Demyelinating Diseases; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000187:drug effects*
D018932:Chemokine CCL2; D054405:Chemokine CCL3; D018946:Chemokine CCL5; D054357:Chemokine CXCL10; D054377:Chemokine CXCL12; D018925:Chemokines