Rest-stimulus interaction in the brain: a review.
Studies in animals and humans have demonstrated intrinsic activity in the brain during the resting state. The concept of the default-mode network (DMN) - a set of brain regions in which resting-state activity (RSA) activity is reduced in response to external stimuli - recently raised much controversy concerning the psychological correlates of RSA. However, it remains unclear how RSA interacts with stimulus-induced activity. Here we review studies in humans and animals that address how RSA interacts with stimulus-induced activity; we also discuss, conversely, how stimulus-induced activity can modulate RSA. Psychologically, the rest-stimulus interaction is relevant to predicting subsequent behavioral and mental states. We conclude that a better understanding of the rest-stimulus interaction is likely to be crucial to the elucidation of the brain's contribution to mental states.
Northoff
Georg
G
Institute of Mental Health Research, University of Ottawa, Ottawa, ON K1Z 7K4, Canada. georg.northoff@rohcg.on.ca
Qin
Pengmin
P
Nakao
Takashi
T
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D001931:Brain Mapping; D006801:Humans; D009043:Motor Activity / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D012146:Rest / Q000502:physiology* / Q000523:psychology