Effects of CO2 laser irradiation of the gingiva during tooth movement.
Patients often feel pain or discomfort in response to orthodontic force. It was hypothesized that CO(2) laser irradiation may reduce the early responses to nociceptive stimuli during tooth movement. The distribution of Fos-immunoreactive (Fos-IR) neurons in the medullary dorsal horn of rats was evaluated. Two hrs after tooth movement, Fos-IR neurons in the ipsilateral part of the medullary dorsal horn increased significantly. CO(2) laser irradiation to the gingiva just after tooth movement caused a significant decrease of Fos-IR neurons. PGP 9.5- and CGRP-positive nerve fibers were observed in the PDL of all study groups. The maximum temperature below the mucosa during CO(2) laser irradiation was less than 40 degrees C. It was suggested that CO(2) laser irradiation reduced the early responses to nociceptive stimuli during tooth movement and might not have adverse effects on periodontal tissue.
Division of Orthodontics and Dentofacial Orthopedics, Tohoku University Graduate School of Dentistry, 4-1, Seiryomachi, Aoba-ku, Sendai, 980-8574, Japan.
M
M
Seiryu
T
T
Deguchi
K
K
Fujiyama
Y
Y
Sakai
T
T
Daimaruya
T
T
Takano-Yamamoto
D000818:Animals; D001831:Body Temperature / Q000502:physiology; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis; D002452:Cell Count; D005881:Gingiva / Q000294:innervation / Q000528:radiation effects*; D054020:Lasers, Gas / Q000627:therapeutic use*; D028022:Low-Level Light Therapy / Q000379:methods*; D008297:Male; D009412:Nerve Fibers / Q000648:ultrastructure; D009434:Neural Pathways / Q000166:cytology; D009474:Neurons / Q000166:cytology; D009619:Nociceptors / Q000166:cytology / Q000528:radiation effects; D010513:Periodontal Ligament / Q000294:innervation / Q000528:radiation effects; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014087:Tooth Movement Techniques / Q000295:instrumentation; D014278:Trigeminal Nuclei / Q000166:cytology; D043222:Ubiquitin Thiolesterase / Q000032:analysis
D016760:Proto-Oncogene Proteins c-fos; C489034:UCHL1 protein, rat; D043222:Ubiquitin Thiolesterase; D015740:Calcitonin Gene-Related Peptide