Non-syndromic oligodontia in permanent dentition of monozygotic twins: report of a rare case.
OBJECTIVE
To report a case of non-syndromic oligodontia involving 26 permanent teeth in monozygotic twin sisters and to discuss the possible genetic etiology, inheritance pattern and associated dental anomalies of this condition.


BACKGROUND
Hypodontia constitutes one of the most common developmental anomalies in humans and is defined as developmental absence of one or more teeth with reported prevalence of 1.6 to 9.6% in the permanent dentition. Oligodontia is defined as agenesis of six or more teeth excluding third molars.


METHODS
This article describes a case of non-syndromic oligodontia involving 26 permanent teeth in monozygotic twin sisters. The twins had positive family history of hypodontia in their paternal grandmother, parental consanguinity (first cousin) and similarity in pattern of oligodontia. Root formation of permanent maxillary first molars and central incisors was delayed in both the twins.


CONCLUSIONS
This article reports a case of non-syndromic oligodontia in permanent dentition of monozygotic twins. Possible genetic etiology, inheritance pattern and associated dental anomalies are discussed.


CONCLUSIONS
Strong genetic link associated with oligodontia help the dentist to know the possibility of its occurrence in other family members and in future generations.
Gadda
Rohit B
RB
Department of Oral Medicine and Radiology at Manipal College of Dental Sciences in Manipal, Karnataka, India. rohitgadda@gmail.com
Pai
Keerthilatha M
KM
Sholapurkar
Amar A
AA
D000848:Anodontia / Q000235:genetics*; D002648:Child; D003241:Consanguinity; D004200:Diseases in Twins / Q000235:genetics*; D005260:Female; D006801:Humans; D007180:Incisor / Q000002:abnormalities; D009805:Odontogenesis / Q000235:genetics; D010375:Pedigree; D014092:Tooth Root / Q000002:abnormalities; D014094:Tooth, Deciduous / Q000002:abnormalities; D014430:Twins, Monozygotic / Q000235:genetics