Pre-stimulation parameters predicting live birth after IVF in the long GnRH agonist protocol.
This retrospective study aimed to identify novel pre-stimulation parameters associated with live birth in IVF and to develop a model for prediction of the chances of live birth at an early phase of the treatment cycle. Data were collected from a randomized trial in couples with unexplained infertility, tubal factor, mild male factor or other reason for infertility. All women (n=731) had undergone an IVF cycle (no intracytoplasmic sperm injection) after stimulation with human menopausal gonadotrophin or follicle-stimulating hormone following the long gonadotrophin-releasing hormone agonist protocol. The univariate tests identified several novel parameters that were significantly (P<0.05) associated with live birth (duration of agonist use, endometrial thickness, pre-stimulation progesterone, androstenedione and total testosterone concentrations, pre-stimulation free androgen index and primary infertility diagnosis), in addition to the well-known predictors female age and duration of infertility. Using multivariable logistic regression analysis, the best predictive model (area under the curve=0.65) was obtained using the parameters age, duration of infertility, infertility diagnosis, endometrial thickness and pre-stimulation total testosterone and sex hormone-binding globulin concentrations. The results indicate that younger age and marked suppression of ovarian steroids prior to starting stimulation may increase the likelihood of live birth in the long protocol.
Clinical Research and Development, Ferring Pharmaceuticals A/S, Copenhagen, Denmark.
Göran
G
Pettersson
Anders Nyboe
AN
Andersen
Per
P
Broberg
Joan-Carles
JC
Arce
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D008297:Male; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome
D007987:Gonadotropin-Releasing Hormone