The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis.
The aetiology of anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis has not been well defined. Here we review two factors which may play a role in the pathogenesis of the disease: genetics and infection. In particular, we discuss the role of autoantibodies to LAMP-2, which may arise following infection with Gram-negative bacteria, and may contribute to the development of ANCA-associated systemic vasculitis in genetically susceptible individuals.
Cambridge Institute for Medical Research and Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0XY, UK.
Lisa C
LC
Willcocks
Paul A
PA
Lyons
Andrew J
AJ
Rees
Kenneth G C
KG
Smith
D000818:Animals; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000235:genetics* / Q000276:immunology* / Q000382:microbiology*; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001424:Bacterial Infections / Q000150:complications / Q000276:immunology*; D003429:Cross Reactions; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D052119:Lysosomal-Associated Membrane Protein 2 / Q000276:immunology; D018716:Molecular Mimicry
D001323:Autoantibodies; D001324:Autoantigens; D052119:Lysosomal-Associated Membrane Protein 2