Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis.
The complexity of the roles of Toll-like receptors (TLRs) is attributable to their ability to promote or suppress autoimmune diseases. Recent studies have demonstrated that B cells regulate autoimmune diseases, including multiple sclerosis (MS), by producing interleukin (IL)-10. By using CpG DNA as a TLR9 agonist, we investigated the immunoregulatory functions of B cell via TLR9 in MS. Our results indicate that TLR9-mediated IL-10 production by B cells was significantly decreased in MS, and this decrease is likely due to decreased TLR9 expression in memory B cells, suggesting a role of TLR9 in immunoregulation in MS.
Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Makoto
M
Hirotani
Masaaki
M
Niino
Toshiyuki
T
Fukazawa
Seiji
S
Kikuchi
Ichiro
I
Yabe
Shinsuke
S
Hamada
Yasutaka
Y
Tajima
Hidenao
H
Sasaki
D000328:Adult; D000704:Analysis of Variance; D015703:Antigens, CD / Q000378:metabolism; D001402:B-Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D016022:Case-Control Studies; D016207:Cytokines / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology*; D009838:Oligodeoxyribonucleotides / Q000494:pharmacology; D051217:Toll-Like Receptor 9 / Q000037:antagonists & inhibitors / Q000378:metabolism*
D015703:Antigens, CD; C408982:CPG-oligonucleotide; D016207:Cytokines; D009838:Oligodeoxyribonucleotides; D051217:Toll-Like Receptor 9; D016753:Interleukin-10