[Role of T-regulatory cells in multiple sclerosis].
Multiple sclerosis (MS) is an autoimmune inflammatory demyelinating disease of the central nervous system (CNS). Most of autoimmune diseases arise by an abnormal activation of the inflammatory response against self-antigens (most of them unknown up to date) as a consequence of dysfunction in peripheral tolerance. Regulatory T-cells are essential for maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory conditions. Based on that knowledge, T-regulatory cells have emerged as a key component of the physiopathology of autoimmune diseases including MS. This review compiles the current knowledge on the role and function of T-regulatory cells in MS, the most prevalent CNS autoimmune disease in humans.
Sección de Neuroinmunología y Enfermedades Desmielinizantes, Servicio de Neurología, Hospital Italiano de Buenos Aires. juan.rojas@hospitalitaliano.org.ar
Juan Ignacio
JI
Rojas
Sergio J
SJ
González
Liliana
L
Patrucco
Edgardo
E
Cristiano
D001324:Autoantigens / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D051858:Forkhead Transcription Factors / Q000502:physiology; D006801:Humans; D007108:Immune Tolerance / Q000502:physiology*; D007249:Inflammation / Q000276:immunology; D009103:Multiple Sclerosis / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000145:classification / Q000276:immunology* / Q000378:metabolism
D001324:Autoantigens; D016207:Cytokines; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors
Rol de las células T regulatorias en esclerosis múltiple.