The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute and early HIV-1 infection.
Acute human immunodeficiency virus type 1 (HIV-1) infection is characterized by high levels of immune activation. Immunomodulation with cyclosporine combined with antiretroviral therapy (ART) in the setting of acute and early HIV-1 infection has been reported to result in enhanced immune reconstitution. Fifty-four individuals with acute and early infection were randomized to receive ART with 4 weeks of cyclosporine versus ART alone. In 48 subjects who completed the study, there were no significant differences between treatment arms in levels of proviral DNA or CD4(+) T cell counts. Adjunctive therapy with cyclosporine in this setting does not provide apparent virologic or immunologic benefit.
Aaron Diamond AIDS Research Center, an affiliate of Rockefeller University, New York, New York, USA. mmarkowitz@adarc.org
Martin
M
Markowitz
Florin
F
Vaida
C Bradley
CB
Hare
Daniel
D
Boden
Hiroshi
H
Mohri
Frederick M
FM
Hecht
Robert C
RC
Kalayjian
Ann
A
Conrad
Donna
D
Mildvan
Judith
J
Aberg
Christine
C
Hogan
J Michael
JM
Kilby
Henry H
HH
Balfour
Kim
K
Schafer
Douglas
D
Richman
Susan
S
Little
D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D019562:Viral Load / Q000187:drug effects
D019380:Anti-HIV Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine