PDZ-based adaptor proteins in epithelial anion transport and VIP receptor regulation.
Polarized protein deposition at the apical and basolateral membranes of epithelial cells is critical for the asymmetrical transport of ions and fluids across the epithelia. PDZ-based modular adaptor proteins are expressed in the junctional areas in epithelial cells and are generally part of a molecular scaffold that determines the localization and activity of ion channels, receptors, and other signaling molecules to their correct spatial arrangement for proper response to diverse stimuli. Hence, understanding the regulatory mechanisms of channels and receptors via PDZ-based adaptors will provide valuable insights into the physiology of epithelial cells as well as pathophysiology of many human diseases including cystic fibrosis.
Gee
Heon Yung
HY
Department of Pharmacology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea.
Park
Hyun Woo
HW
Kim
Kyung Hwan
KH
Lee
Min Goo
MG
D033942:Adaptor Proteins, Vesicular Transport / Q000502:physiology*; D000818:Animals; D000838:Anions / Q000378:metabolism; D001692:Biological Transport / Q000502:physiology; D004847:Epithelial Cells / Q000502:physiology*; D006801:Humans; D054731:PDZ Domains / Q000502:physiology*; D018005:Receptors, Vasoactive Intestinal Peptide / Q000378:metabolism; D019108:Tight Junctions / Q000502:physiology
D033942:Adaptor Proteins, Vesicular Transport; D000838:Anions; D018005:Receptors, Vasoactive Intestinal Peptide