Evaluation of a new press-fit in situ setting composite porous scaffold for cancellous bone repair: towards a "surgeon-friendly" bone filler?
In this study, a composite porous material obtained by coating a poly(ester urethane) foam with a calcium phosphate cement is proposed as novel cancellous bone filler with easy handling, in situ hardening and press-fitting properties. The coating can be applied to the foam in the surgical theater, allowing refinement of scaffold shape to the needs of the ongoing surgery. An innovative experiment was developed in order to determine the setting curve of the composite scaffold as well as the time of manipulation available to the surgeon without risk of material damage. This composite material is soft and can be press-fit in a cavity without damaging the scaffold in the first 5 min after coating application. The composite scaffold hardens quickly (22 min) and, once the cement has set, its compressive strength and fracture energy are increased by over an order of magnitude as compared to the initial poly(ester urethane) foam. This set of interesting properties makes calcium phosphate cement-coated elastomeric scaffolds a new promising strategy for cancellous bone filling.
Université de Lyon, INSA-Lyon, MATEIS, CNRS UMR 5510, 20 Avenue Albert Einstein, Bâtiment Blaise Pascal, 69621 Villeurbanne Cedex, France. marianna.peroglio@aofoundation.org
M
M
Peroglio
L
L
Gremillard
D
D
Eglin
P
P
Lezuo
M
M
Alini
J
J
Chevalier
D018786:Bone Substitutes / Q000032:analysis*; D001842:Bone and Bones / Q000473:pathology*; D006244:Hardness; D008422:Materials Testing / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D016062:Porosity; D054457:Tissue Scaffolds / Q000737:chemistry*; D014945:Wound Healing
D018786:Bone Substitutes