BCL6 and BCoR gang up on Notch to regulate left-right patterning.
In this issue of Developmental Cell, Sakano et al. describe a novel mechanism of how a key lymphocyte transcription factor crosstalks to Notch signaling during embryonic development and thereby selectively inhibits Notch-activated target genes to allow proper left-right patterning.
Koch
Ute
U
Ecole Polytechnique Fédérale de Lausanne, Swiss Institute for Experimental Cancer Research, Station 19, 1015 Lausanne, Switzerland.
Radtke
Freddy
F
D000818:Animals; D019521:Body Patterning / Q000235:genetics / Q000502:physiology; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014981:Xenopus / Q000196:embryology* / Q000235:genetics / Q000378:metabolism*; D029867:Xenopus Proteins / Q000235:genetics / Q000378:metabolism*
D051880:Receptors, Notch; D012097:Repressor Proteins; D014157:Transcription Factors; D029867:Xenopus Proteins