Adenosine A(1) receptors contribute to mitochondria vulnerability to pro-oxidant stressors.
A(1) adenosine receptors are highly expressed in the central nervous system. Mitochondrial function is a major player in adenosine receptors-mediated effects. Here, by using mice with genetic deletion of the A(1) receptor, we addressed the existence of a relationship between mitochondria functions and adenosine A(1) receptor. Mitochondrial functions and effects of MPP(+) in primary mixed cultures are influenced by the presence of the A(1) receptor, demonstrating, for the first time, the mitochondrial localization of the adenosine A(1) receptor and suggesting a role for this receptor as a mitochondrial vulnerability factor.
Minelli
Alba
A
Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Sezione di Biochimica Cellulare, Università di Perugia, Via del Giochetto, 06123 Perugia, Italia. aminelli@unipg.it
Grottelli
Silvia
S
Corazzi
Lanfranco
L
Bellezza
Ilaria
I
Rambotti
Maria Grazia
MG
Emiliani
Carla
C
Fredholm
Bertil B
BB
D015655:1-Methyl-4-phenylpyridinium / Q000633:toxicity*; D000818:Animals; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000633:toxicity*; D043682:Receptor, Adenosine A1 / Q000172:deficiency / Q000502:physiology*; D013312:Stress, Physiological
D017382:Reactive Oxygen Species; D043682:Receptor, Adenosine A1; D015655:1-Methyl-4-phenylpyridinium