A basic approach to CKD.
Metabolic acidosis often complicates chronic kidney disease (CKD) and adversely affects bone, nutrition, and metabolism. Phisitkul et al. demonstrate that sodium citrate may ameliorate kidney injury in CKD patients not on dialysis. Further, they provide evidence in humans that treatment lowers urinary endothelin levels, and hence increased endothelin may be part of the mechanism whereby acidosis hastens CKD progression.
Simon
Eric E
EE
Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.
Hamm
L Lee
LL
D000138:Acidosis / Q000188:drug therapy* / Q000209:etiology / Q000652:urine; D002021:Buffers; D002951:Citrates / Q000627:therapeutic use*; D019332:Endothelin-1 / Q000652:urine; D006801:Humans; D051436:Renal Insufficiency, Chronic / Q000150:complications / Q000188:drug therapy*; D000077559:Sodium Citrate
D002021:Buffers; D002951:Citrates; D019332:Endothelin-1; D000077559:Sodium Citrate