Subcutaneous injection of water-soluble multi-walled carbon nanotubes in tumor-bearing mice boosts the host immune activity.
The immunological responses induced by oxidized water-soluble multi-walled carbon nanotubes on a hepatocarcinoma tumor-bearing mice model via a local administration of subcutaneous injection were investigated. Experimental results show that the subcutaneously injected carbon nanotubes induced significant activation of the complement system, promoted inflammatory cytokines' production and stimulated macrophages' phagocytosis and activation. All of these responses increased the general activity of the host immune system and inhibited the progression of tumor growth.
Meng
Jie
J
Department of Biomedical Engineering, Institute of Basic Medical Sciences & School of Basic Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People's Republic of China.
Yang
Man
M
Jia
Fumin
F
Kong
Hua
H
Zhang
Weiqi
W
Wang
Chaoying
C
Xing
Jianmin
J
Xie
Sishen
S
Xu
Haiyan
H
D000818:Animals; D049109:Cell Proliferation; D003167:Complement Activation / Q000276:immunology; D003176:Complement C3 / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis / Q000378:metabolism; D007109:Immunity / Q000276:immunology*; D007279:Injections, Subcutaneous; D008264:Macrophages / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D009928:Organ Specificity; D010587:Phagocytosis; D040081:Protein Array Analysis; D012995:Solubility; D012996:Solutions; D014867:Water / Q000737:chemistry*
D003176:Complement C3; D016207:Cytokines; D037742:Nanotubes, Carbon; D012996:Solutions; D014867:Water