Clinical pharmacokinetics and interaction of centchroman--a mini review.
This article provides a brief review of the information available regarding the published pharmacokinetics data for the nonsteroidal, once-a-week oral contraceptive, centchroman (INN: ormeloxifene). This agent is a unique need-oriented contraceptive agent which is included in the National Family Welfare Programme of India. Since 1991, centchroman has been used as a need-oriented contraceptive and is being given for treating dysfunctional bleeding of the uterus. Information regarding absorption, tissue distribution, elimination and kinetic interactions is discussed.
Pharmacokinetics and Metabolism Division, Central Drug Research Institute, CSIR, Lucknow, India. jlalcdri@rediffmail.com
Jawahar
J
Lal
D000818:Animals; D002486:Centchroman / Q000493:pharmacokinetics*; D003276:Contraceptives, Oral / Q000493:pharmacokinetics*; D003283:Contraceptives, Postcoital, Synthetic / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007194:India; D051381:Rats; D014592:Uterine Hemorrhage / Q000188:drug therapy
D003276:Contraceptives, Oral; D003283:Contraceptives, Postcoital, Synthetic; D002486:Centchroman