Bioconjugates of curcumin display improved protection against glutathione depletion mediated oxidative stress in a dopaminergic neuronal cell line: Implications for Parkinson's disease.
Oxidative stress is implicated in mitochondrial dysfunction associated with neurodegeneration in Parkinson's disease (PD). Depletion of the cellular antioxidant glutathione (GSH) resulting in oxidative stress is considered as an early event in neurodegeneration. We previously showed that curcumin, a dietary polyphenol from turmeric induced GSH synthesis in experimental models and protected against oxidative stress. Here we tested the effect of three bioconjugates of curcumin (involving diesters of demethylenated piperic acid, valine and glutamic acid) against GSH depletion mediated oxidative stress in dopaminergic neuronal cells and found that the glutamic acid derivative displayed improved neuroprotection compared to curcumin.
Harish
G
G
Department of Neurochemistry, National Institute of Mental Health and Neurosciences, #2900, Hosur Road, Bangalore 560 029, Karnataka, India.
Venkateshappa
C
C
Mythri
Rajeswara Babu
RB
Dubey
Shiv Kumar
SK
Mishra
Krishna
K
Singh
Neetu
N
Vali
Shireen
S
Bharath
M M Srinivas
MM
D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D001682:Biological Availability; D002460:Cell Line; D003474:Curcumin / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology*; D005978:Glutathione / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007202:Indicators and Reagents; D015227:Lipid Peroxidation / Q000187:drug effects; D008958:Models, Molecular; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D010300:Parkinson Disease / Q000188:drug therapy*; D017382:Reactive Oxygen Species / Q000378:metabolism
D000975:Antioxidants; D007202:Indicators and Reagents; D018696:Neuroprotective Agents; D016877:Oxidants; D017382:Reactive Oxygen Species; D006861:Hydrogen Peroxide; D005982:Glutathione Transferase; D005978:Glutathione; D003474:Curcumin; D004298:Dopamine