Cardiac release and kinetics of cytokines after elective bare metal coronary stenting.
The study was designed to assess the cardiac release kinetics of the cytokines interleukin-1ß (IL-1ß), interleukin-6 (IL-6) and tumor-necrosis-factor-α (TNF-α) in patients with significant stenosis of the ramus interventricularis anterior. Ten patients were treated by bare metal stent implantation, 11 patients who underwent a diagnostic coronary angiography without intervention served as a control group. Cytokines paired blood samples were withdrawn from the coronary sinus and a peripheral vein immediately before and 1, 2, 6 h after the intervention. Myocardial ischemia was monitored by means of cardiac lactate metabolism and 12-lead electrocardiogram. After coronary intervention IL-6 gradually increased from a common baseline level of 1.34 ± 1.56 pg/ml to a maximum of 10.58 ± 5.7 pg/ml in the peripheral vein and 15.81 ± 6.98 pg/ml in the coronary sinus within 6 h with persistent higher levels in the coronary sinus indicating coronary IL-6 release. After 12 h the peripheral venous concentration of IL-6 returned to baseline levels. Neither in the study group for IL-1ß and TNF-α nor in the control group for any cytokine level significant changes were found. Myocardial ischemia was excluded in all patients. Uncomplicated percutaneous coronary intervention (PCI) was followed by a significant cardiac IL-6 release due to endothelial injury and not to myocardial ischemia.
Department of Cardiology, University Hospital Schleswig-Holstein, Campus Kiel, Schittenhelmstr. 12, Kiel 24105, Germany.
NourEddine
N
ElMokhtari
Sascha
S
Zschernitz
Susanne
S
Sebens
Gunhild
G
Simon-Herrmann
Dietmar
D
Krüger
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000295:instrumentation; D023921:Coronary Stenosis / Q000097:blood / Q000628:therapy; D017558:Elective Surgical Procedures / Q000009:adverse effects / Q000295:instrumentation*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood / Q000378:metabolism*; D015850:Interleukin-6 / Q000097:blood* / Q000378:metabolism*; D008297:Male; D008670:Metals; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D015607:Stents / Q000009:adverse effects; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000378:metabolism*
D053583:Interleukin-1beta; D015850:Interleukin-6; D008670:Metals; D014409:Tumor Necrosis Factor-alpha