Central nervous system anomalies diagnosed antenatally and post-delivery management.
OBJECTIVE
To find out the prevalence of the central nervous system anomalies (CNS) and the outcome after surgical correction of operable defects.


METHODS
This is a retrospective review of all cases diagnosed antenatally with CNS anomalies in the Department of Obstetrics and Gynecology at King Abdulaziz University Hospital (KAUH), Jeddah, Kingdom of Saudi Arabia from January 1997 to March 2005, and their outcome including perinatal deaths and postoperative outcome following surgical correction carried out as treatment or palliative.


RESULTS
Ninety CNS anomalies were diagnosed antenatally, and 86 were confirmed postnatally. Forty-one (47.7%) were neural tube defects (NTDs) (24 were spina bifida associated with hydrocephalus, 3 encephalocele, 14 anencephaly), 36 (41.9%) were hydrocephalus, 4 (4.65%) holoprosencephaly, 3 (3.4%) microcephaly, and 2 (2.32%) with brain cysts. Of the 41 cases that were operated, 6 (14.6%) died, 26 (63.4%) survived with severe neurological sequelae, 6 (14.6%) lost follow-up, and 3 (7.3%) did well for the period of follow-up.


CONCLUSIONS
The prevalence of CNS anomalies is comparable to worldwide prevalence. The NTDs are important component of these anomalies, and implementation of strategies to decrease the rate of these anomalies would be beneficial to prevent them as they carry a high rate of handicap and suffering, even after surgical correction.
Mansouri
Haifaa A
HA
Department of Obstetrics and Gynecology, King Abdulaziz University Hospital, PO Box 80215, Jeddah 21589, Kingdom of Saudi Arabia. hamansouri@yahoo.com
D002490:Central Nervous System / Q000002:abnormalities* / Q000601:surgery; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D009436:Neural Tube Defects / Q000175:diagnosis; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012189:Retrospective Studies