Effects of sub-chronic clozapine and haloperidol administration on brain lipid levels.
Abnormal lipid profiles have been reported in the central nervous system (CNS) in individuals with schizophrenia, although the etiology of these changes remains to be elucidated. While treatment with second-generation antipsychotics has been associated with alterations in peripheral lipid levels and changes in erythrocyte membrane composition, the relationship between peripheral and CNS lipid levels is complex and the effect of antipsychotics on CNS lipid regulation is not yet understood. In this study we investigated whether sub-chronic administration of the second-generation antipsychotic clozapine and the first-generation antipsychotic haloperidol alters brain membrane lipid composition in male Sprague-Dawley rats. The relationship between brain membrane lipid composition and plasma cholesterol concentrations was also assessed. Our results indicate that brain lipid composition and plasma cholesterol concentrations are not altered following administration of antipsychotics. No correlation was observed between plasma and brain membrane cholesterol levels. Our findings suggest that observed alterations in brain lipid profiles in individuals with schizophrenia are not a consequence of treatment with antipsychotic medications.
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.
Vilte E
VE
Barakauskas
Athena R
AR
Ypsilanti
Alasdair M
AM
Barr
Sheila M
SM
Innis
William G
WG
Honer
Clare L
CL
Beasley
D000704:Analysis of Variance; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D002784:Cholesterol / Q000032:analysis* / Q000097:blood; D003024:Clozapine / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D010743:Phospholipids / Q000032:analysis*; D051381:Rats; D017207:Rats, Sprague-Dawley
D014150:Antipsychotic Agents; D010743:Phospholipids; D002784:Cholesterol; D003024:Clozapine; D006220:Haloperidol