[Emotional stress in the development of experimental hemorrhagic stroke in rats with different resistance to stress].
Individual behavioral characteristics of rats in the open-field test reflect their resistance to emotional stress and determine the severity of neurological disorders during intracerebral hemorrhage. Stress-resistant rats are characterized by a more rapid restoration of neurological status and disappearance of locomotor and coordination disturbances on day 7 after unilateral hemorrhage stroke in the caudate nucleus as compared to stress-predisposed animals. After hemorrhage stroke in the caudate nucleus, changes in vessels and neurons of the contralateral sensorimotor cortex were more pronounced in stress-predisposed passive rats than in stress-resistant active animals. The newly formed capillaries were not seen in stress-predisposed specimens. To day 7 of post stress hemorrhage stroke in the caudate nucleus, signs of the involvement of compensatory mechanisms in the contralateral sensorimotor cortex appeared in stress-resistant but not in stress-predisposed rats. This finding suggests the possibility of restoration of structure and normal functioning of neurons.
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Ivannikova
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Koplik
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Popova
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KV
Sudakov
D000223:Adaptation, Psychological / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002421:Caudate Nucleus / Q000098:blood supply; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology; D004195:Disease Models, Animal; D018450:Disease Progression; D005500:Follow-Up Studies; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D020127:Recovery of Function / Q000502:physiology*; D013003:Somatosensory Cortex / Q000502:physiology*; D013315:Stress, Psychological / Q000150:complications* / Q000523:psychology; D020521:Stroke / Q000209:etiology* / Q000503:physiopathology / Q000523:psychology