Rapid loss of appendicular skeletal muscle mass is associated with higher all-cause mortality in older men: the prospective MINOS study.
BACKGROUND
Changes in body composition underlying the association between weight loss and higher mortality are not clear.


OBJECTIVE
The objective was to investigate the association between changes in body composition of the appendicular (4 limbs) and central (trunk) compartments and all-cause mortality in men.


METHODS
In men aged > or = 50 y, body composition was assessed every 18 mo for 7.5 y with a whole-body dual-energy X-ray absorptiometry scan. Mortality was assessed for 10 y. Data were analyzed by logistic regression and Cox model and adjusted for age, body mass index (BMI), educational level, lifestyle, physical performance, comorbidities, body composition, and serum concentrations of 17beta-estradiol and 25-hydroxycholecalciferol.


RESULTS
Of 715 men who were followed up, 137 (19.2%) died. Mortality was higher in men with the fastest weight loss [lowest compared with middle tertile odds ratio (OR): 2.31; 99% CI: 1.05, 5.09]. Faster loss of appendicular skeletal muscle mass (ASMM) was predictive of mortality (lowest compared with middle tertile OR: 3.60; 99% CI: 1.64, 7.89). Faster loss in ASMM remained a strong predictor of mortality after adjustment for weight loss (OR: 3.41; 99% CI: 1.51, 7.71). Faster loss in ASMM was the strongest predictor of death in the stepwise procedures when it was analyzed jointly with changes in the mass of other compartments. Loss in ASMM calculated over 36 mo was also a stronger predictor of death than were changes in the mass of other compartments (hazard ratio: 1.33 per 1-SD decrease; 95% CI: 1.06, 1.66).


CONCLUSIONS
The accelerated loss of ASMM is predictive of all-cause mortality in older men regardless of age, BMI, lifestyle, physical performance, health status, body composition, and serum 17beta-estradiol and 25-hydroxycholecalciferol.
Szulc
Pawel
P
INSERM Unit 831, University of Lyon, Lyon, France. pawel.szulc@inserm.fr
Munoz
Françoise
F
Marchand
François
F
Chapurlat
Roland
R
Delmas
Pierre D
PD
D015502:Absorptiometry, Photon; D000368:Aged; D001823:Body Composition; D015992:Body Mass Index; D002112:Calcifediol / Q000097:blood; D004522:Educational Status; D004958:Estradiol / Q000097:blood; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000033:anatomy & histology*; D009929:Organ Size; D010024:Osteoporosis / Q000401:mortality*; D012044:Regression Analysis; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D015431:Weight Loss / Q000502:physiology*
D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol; D002112:Calcifediol