[Polychloro biphenils (PCBS) and cancer].
A lot of studies treat the issue of PCBs and cancer. The weight of evidence in studies of environmental exposure or increased mortality in subjects professionally exposed does not support a causal association for PCBs and human cancer. The main international agencies classified PCB as probable carcinogenicity, limited evidences in humans and sufficient on the animals. The present report would to resume the principals epidemiological and experimental studies with the purpose to show its weak and/or discordant points and to underline the critical aspects of the evaluation of the exposure. Critics are the identification of the congeners more diffused and persistent and therefore more representative and the correlation with early effects or specific metabolic alterations.
Apostoli
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P
Dipartimento di Medicina Sperimentale e Applicata, Sezione di Medicina del Lavoro e Igiene Industriale, Università degli Studi di Brescia. apostoli@med.unibs.it
Bergonzi
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R
Catalani
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S
D000818:Animals; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced*; D011078:Polychlorinated Biphenyls / Q000633:toxicity*
D004785:Environmental Pollutants; D011078:Polychlorinated Biphenyls
Policlorobifenili (PCB) e cancro.