Development of various arrhythmias and conduction disturbances following corticosteroid therapy for systemic lupus erythematosus with antiphospholipid syndrome.
A 45-year-old Chinese woman with active systemic lupus erythematosus, lupus anticoagulant positive, was admitted to our hospital. Electrocardiography on admission was normal. Though anti-Sjögren's syndrome A (anti SS-A/Ro) antibodies were negative and ultrasound cardiographic findings were normal, she developed various arrhythmias/conduction disturbances shortly after starting corticosteroid. Nearly all were resolved with continuous corticosteroid and aspirin therapy before discharge. Vasculitis, the presence of antiphospholipid antibodies, and platelet aggregation due to corticosteroid were possible mechanisms underlying the arrhythmias/conduction disturbances.
Department of Internal Medicine, Osaka City General Hospital, Miyakojima-ku, Osaka, Japan. yu-gyne@mail.goo.ne.jp
Yu
Y
Kasamatsu
Katsunobu
K
Yoshioka
Tomoko
T
Miyashita
Mikiko
M
Shibata
Tomoyuki
T
Nakamura
Keiko
K
Yamagami
D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D016736:Antiphospholipid Syndrome / Q000188:drug therapy* / Q000276:immunology; D004562:Electrocardiography; D005260:Female; D006327:Heart Block / Q000139:chemically induced* / Q000175:diagnosis; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy* / Q000276:immunology; D008875:Middle Aged
D000305:Adrenal Cortex Hormones; D016682:Lupus Coagulation Inhibitor