Formulation and evaluation of multiple tablets as a biphasic gastroretentive floating drug delivery system for fenoverine.
A biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L(-1) HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability studies showed no significant change in dissolution profiles (f2 value > 50). Based on the release kinetics, it can be concluded that the floating multiple matrix tablet containing HPMC was a particularly suitable gastroretentive drug delivery system with a zero-order release profile.
Bandari
Suresh
S
Centre for Biopharmaceutics and Pharmacokinetics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal-506009 (A.P.), India.
Eaga
Chandra Mohan
CM
Thadishetty
Ashok
A
Yamsani
Madhusudan Rao
MR
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000138:chemical synthesis / Q000493:pharmacokinetics; D004337:Drug Carriers; D016503:Drug Delivery Systems / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005765:Gastrointestinal Agents / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D010640:Phenothiazines / Q000008:administration & dosage* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D013607:Tablets; D010879:Piperazines
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005765:Gastrointestinal Agents; D010640:Phenothiazines; D013607:Tablets; C048314:fenoverine; D010879:Piperazines