New amide alkaloid from the aerial part of Piper capense L.f. (Piperaceae).
Together with apigenine dimethylether and piperchabamide A, a new amide alkaloid, Kaousine and the Z form of antiepilepsirine were isolated from the aerial part of Piper capense L.f (Piperaceae). Their structures were elucidated by spectrometric methods and their in vitro antiparasitic activities were evaluated on Plasmodium falciparum.
Laboratoire de Pharmacognosie et Ethnopharmacologie, UMR-MD3, Faculté de Pharmacie, Université de la Méditerranée Aix-Marseille II, 27 Bd Jean Moulin, 13385 Marseille Cedex 5, France.
Ali Mohamed
AM
Kaou
Valérie
V
Mahiou-Leddet
Cécile
C
Canlet
Laurent
L
Debrauwer
Sébastien
S
Hutter
Nadine
N
Azas
Evelyne
E
Ollivier
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D000577:Amides / Q000737:chemistry / Q000302:isolation & purification*; D000962:Antimalarials / Q000302:isolation & purification*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification; D045744:Cell Line, Tumor; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D031701:Piper / Q000737:chemistry*; D010880:Piperidines / Q000302:isolation & purification; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
D000470:Alkaloids; D000577:Amides; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D004852:Epoxy Compounds; D010880:Piperidines; D010936:Plant Extracts; C553702:kaousine; C037547:ilepcimide