[Peritoneal fluid iron levels in women with endometriosis].
OBJECTIVE
Endometriosis is characterized by a cyclic hemorrhage within the peritoneal cavity. Accumulating data suggests that iron homeostasis in the peritoneal cavity may be disrupted by endometriosis. The aim of our study was to evaluate iron levels in peritoneal fluid (PF) of women with and without endometriosis.


METHODS
Seventy-five women were studied: 50 women with endometriosis and, as a reference group, 25 patients with functional follicle ovarian cysts. Iron concentrations in the PF were measured using a commercially available colorimetric assay kit.


RESULTS
Iron concentrations were significantly higher in PF from women with endometriosis as compared to the reference group. Patients with stages III/IV endometriosis had significantly higher PF iron concentrations than women with stages I/II of the disease.


CONCLUSIONS
Disrupted iron homeostasis in the peritoneal cavity of women with endometriosis plays a role in the pathogenesis of the disease.
Polak
Grzegorz
G
I Katedra i Klinika Ginekologii Onkologicznej i Ginekologii Uniwersytetu Medycznego w Lublinie. polakg@yahoo.com
Wertel
Iwona
I
Tarkowski
Rafał
R
Kotarski
Jan
J
D000328:Adult; D001202:Ascitic Fluid / Q000737:chemistry*; D015415:Biomarkers / Q000032:analysis; D018450:Disease Progression; D004715:Endometriosis / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005293:Ferritins / Q000032:analysis*; D006801:Humans; D010048:Ovarian Cysts / Q000378:metabolism; D010537:Peritoneum / Q000737:chemistry*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D055815:Young Adult
D015415:Biomarkers; D005293:Ferritins
Stezenie zelaza w płynie otrzewnowym kobiet z endometrioza.