The development of radiogallium-acetylacetonate bis(thiosemicarbazone) complex for tumour imaging.
BACKGROUND
Various radiometal complexes have been developed for tumour imaging, especially Ga-68 tracer. In this work, the development of a radiogallium bis(thiosemicarbazone) complex has been reported.


METHODS
[(67)Ga]acetylacetonate bis(thio-semicarbazone) complex ([(67)Ga]AATS) was prepared starting with [(67)Ga]Gallium acetate and freshly prepared acetylacetonate bis(thiosemicarbazone) (AATS) for 30 min at 90 degreesC. The partition co-efficient and stability of the tracer was determined in final solution (25 degreesC) and the presence of human serum (37 degreesC) for up to 24 hours. The biodistribution of the labelled compound in wild-type and fibrosarcoma-bearing rodents were determined for up to 72 hours.


RESULTS
The radiolabelled Ga complex was prepared to a high radiochemical purity (> 97%, HPLC) followed by initial biodistribution data with the significant tumour accumulation of the tracer at two hours, which is far higher than free Ga-67 cation, while the compound wash-out is significantly faster.


CONCLUSIONS
The above-mentioned pharmacokinetic properties suggest an interesting radiogallium complex prepared by the PET Ga radioisotope, (68)Ga, in accordance with the physical half life, for use in fibrosarcoma tumours and possibly in other malignancies.
Nuclear Medical Research Group, Agricultural, Medical, and Industrial Research School, Karaj, Iran. ajalilian@nrcam.org
Amir R
AR
Jalilian
Hassan
H
Yousefnia
Javad
J
Garousi
Aytak
A
Novinrouz
Amir A
AA
Rajamand
Kamaledin
K
Shafaee
D000818:Animals; D005354:Fibrosarcoma / Q000000981:diagnostic imaging* / Q000378:metabolism*; D006801:Humans; D007553:Isotope Labeling / Q000379:methods; D008657:Metabolic Clearance Rate; D009928:Organ Specificity; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D051381:Rats; D014018:Tissue Distribution
D019275:Radiopharmaceuticals