Valproate-induced hyperacute hyperammonemic coma in a patient with hypocarnitinemia.
Valproate-associated hyperammonemic coma in adults is a rare complication of valproate therapy and has been previously reported to occur in few days to years after initiation of therapy. We present a case of hyperammonemic coma induced within hours of initiating valproate therapy in a patient with plasma carnitine deficiency.
Sofi
Aijaz
A
1Department of Internal Medicine; and 2Department of Neurology, University of Toledo College of Medicine, Toledo, OH.
Herial
Nabeel A
NA
Ali
Imran I
II
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D002331:Carnitine / Q000097:blood / Q000172:deficiency*; D003128:Coma / Q000139:chemically induced*; D005260:Female; D006801:Humans; D013997:Time Factors; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
D000927:Anticonvulsants; D014635:Valproic Acid; D002331:Carnitine