Branching morphogenesis in the fetal mouse submandibular gland is codependent on growth factors and extracellular matrix.
Branching morphogenesis (BrM) is a basic developmental process for the formation of the lung, kidney, and all exocrine glands, including the salivary glands. This process proceeds as follows. An epithelial downgrowth invaginates into underlying mesenchyme, and forms a cleft at its distal end, which is the site of dichotomous branching and elongation; this process of clefting and elongation is repeated many times at the distal ends of the invading epithelium until the desired final extent of branching is reached. The distal ends of the epithelium differentiate into the secretory endpieces, and the elongated segments become the ducts. This presentation is a brief historical review of studies on BrM during the development of the submandibular gland (SMG).
Gresik
Edward W
EW
Department of Cell Biology and Anatomy, Sophie Davis School of Biomedical Education, City University of New York, NY, USA.
Koyama
Noriko
N
Hayashi
Toru
T
Kashimata
Masanori
M
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D004847:Epithelial Cells / Q000166:cytology / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology*; D051379:Mice; D009024:Morphogenesis / Q000502:physiology*; D013363:Submandibular Gland / Q000166:cytology / Q000196:embryology* / Q000254:growth & development
D036341:Intercellular Signaling Peptides and Proteins