A totally synthetic glucose responsive gel operating in physiological aqueous conditions.
Here described is a phenylboronic acid (PBA) based glucose-responsive hydrogel operating under physiological pH and temperature, a material potentially applicable to a totally synthetic smart insulin delivery system to treat diabetes.
Center for NanoBio Integration, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. amatsumoto@bmw.t.u-tokyo.ac.jp
Akira
A
Matsumoto
Kazuya
K
Yamamoto
Ryo
R
Yoshida
Kazunori
K
Kataoka
Takao
T
Aoyagi
Yuji
Y
Miyahara
D001897:Boronic Acids / Q000737:chemistry; D016503:Drug Delivery Systems; D005782:Gels / Q000138:chemical synthesis* / Q000737:chemistry; D005947:Glucose / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000008:administration & dosage; D013696:Temperature; D014867:Water / Q000737:chemistry*
D001897:Boronic Acids; D005782:Gels; D007328:Insulin; D014867:Water; D005947:Glucose; C010686:benzeneboronic acid