Stereoselective synthesis of configurationally stable functionalized ethano-bridged Tröger bases.
New functionalized ethano-bridged Tröger bases are readily prepared using a simple alkylation/rearrangement sequence which affords configurationally stable derivatives as single stereoisomers (de > 96%).
Michon
Christophe
C
Department of Organic Chemistry, Quai Ernest Ansermet 30, Ch-1211 Geneva 4, Switzerland.
Sharma
Ankit
A
Bernardinelli
Gérard
G
Francotte
Eric
E
Lacour
Jérôme
J
D000478:Alkylation; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D018360:Crystallography, X-Ray; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D013237:Stereoisomerism
D001952:Bridged-Ring Compounds; D006576:Heterocyclic Compounds, 4 or More Rings