Two-step synthesis of substituted 3-aminoindazoles from 2-bromobenzonitriles.
A general two-step synthesis of substituted 3-aminoindazoles from 2-bromobenzonitriles involving a palladium-catalyzed arylation of benzophenone hydrazone followed by an acidic deprotection/cyclization sequence is described. This procedure offers a general and efficient alternative to the typical S(N)Ar reaction of hydrazine with o-fluorobenzonitriles.
Centre d'Etudes et de Recherche sur le Médicament de Normandie, UPRES EA 4258, INC3M FR-CNRS 3038, UFR des Sciences Pharmaceutiques, Université de Caen Basse-Normandie, boulevard Becquerel 14032 Caen Cedex, France.
Valerie
V
Lefebvre
Thomas
T
Cailly
Frederic
F
Fabis
Sylvain
S
Rault
D001577:Benzophenones / Q000737:chemistry; D003500:Cyclization; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry*
D001577:Benzophenones; D007191:Indazoles; D009570:Nitriles; C047723:benzophenone; C014356:benzonitrile