Lack of social support in the etiology and the prognosis of coronary heart disease: a systematic review and meta-analysis.
OBJECTIVE
To conduct a systematic review and meta-analysis on the relevance of low social support for the development and course of coronary heart disease (CHD).


METHODS
Three electronic databases were searched (MEDLINE, PsycINFO/PSYNDEX, and Web of Science 2007/03). More than 1700 papers were screened in a first step. We included prospective studies assessing the impact of social support in either an initially healthy study population (etiologic studies) or in a study population with preexisting CHD (prognostic studies).


RESULTS
Myocardial infarction in etiologic studies; cardiovascular mortality and all-cause mortality in prognostic studies. Effects were reported as relative risk (RR) or hazard ratio (HR).


RESULTS
There is some evidence for an impact of low functional social support on the prevalence of CHD in etiologic studies (RR, range, 1.00-2.23). In contrast, there is no evidence of an impact of low structural social support on the prevalence of myocardial infarction in healthy populations (RR, range, 1.01-1.2). In prognostic studies, results consistently show that low functional support negatively affects cardiac and all-cause mortality (pooled RR, range, 1.59-1.71). These results were also confirmed in analyses adjusted for other risk factors for disease progression (pooled HR, 1.59). It remains unclear whether low structural social support increases mortality in patients with CHD (pooled RR, between 1.56; pooled HR, 1.12, NS).


CONCLUSIONS
Because the perception of social support seems important for CHD prognosis, monitoring of functional social support is indicated in patients with CHD, and interventions to increase the perception of positive social resources are warranted.
Institute of Social and Preventive Medicine (ISPM), University of Bern, Niesenweg 6, CH-3012 Bern, Switzerland. mail@juergen-barth.de
Jürgen
J
Barth
Sarah
S
Schneider
Roland
R
von Känel
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003327:Coronary Disease / Q000175:diagnosis* / Q000209:etiology* / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000209:etiology / Q000523:psychology; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D012938:Social Perception; D012944:Social Support