Mechanisms of carbapenem resistance among a collection of Enterobacteriaceae clinical isolates in a Texas city.
Fourteen Enterobacteriaceae isolates with ertapenem MIC >2 mg/mL were analyzed to identify mechanisms of resistance. All isolates produced extended-spectrum beta-lactamase or AmpC beta-lactamase with variable, but decreased, expression of outer membrane proteins. One Enterobacter cloacae produced derepressed AmpC beta-lactamase, 1 Escherichia coli expressed plasmid-mediated AmpC beta-lactamase, and 1 E. cloacae produced a carbapenemase.
Bennett
Jason W
JW
Department of Medicine, San Antonio Military Medical Center, Fort Sam Houston, Texas 78234, USA.
Mende
Katrin
K
Herrera
Monica L
ML
Yu
Xin
X
Lewis
James S
JS
Wickes
Brian L
BL
Jorgensen
James H
JH
Murray
Clinton K
CK
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001425:Bacterial Outer Membrane Proteins / Q000096:biosynthesis; D001426:Bacterial Proteins / Q000096:biosynthesis; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000382:microbiology*; D000077727:Ertapenem; D006801:Humans; D008826:Microbial Sensitivity Tests; D010957:Plasmids; D013781:Texas; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000096:biosynthesis*; D047090:beta-Lactams / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D047090:beta-Lactams; D001618:beta-Lactamases; D000077727:Ertapenem