[Evaluation of a simplified index (spectral entropy) about sleep state of electrocardiogram recorded by a simplified polygraph, MemCalc-Makin2].
BACKGROUND
Polysomnography (PSG) is the gold standard for the diagnosis of sleep apnea hypopnea syndrome (SAHS), but it takes time to analyze the PSG and PSG cannot be performed repeatedly because of efforts and costs. Therefore, simplified sleep respiratory disorder indices in which are reflected the PSG results are needed. The Memcalc method, which is a combination of the maximum entropy method for spectral analysis and the non-linear least squares method for fitting analysis (Makin2, Suwa Trust, Tokyo, Japan) has recently been developed. Spectral entropy which is derived by the Memcalc method might be useful to expressing the trend of time-series behavior.


OBJECTIVE
Spectral entropy of ECG which is calculated with the Memcalc method was evaluated by comparing to the PSG results.


METHODS
Obstructive SAS patients (n = 79) and control volanteer (n = 7)


METHODS
ECG was recorded using MemCalc-Makin2 (GMS) with PSG recording using Alice IV (Respironics) from 20:00 to 6:00. Spectral entropy of ECG, which was calculated every 2 seconds using the Memcalc method, was compared to sleep stages which were analyzed manually from PSG recordings.


RESULTS
Spectral entropy value (-0.473 vs. -0.418, p < 0.05) were significantly increased in the OSAHS compared to the control. For the entropy cutoff level of -0.423, sensitivity and specificity for OSAHS were 86.1% and 71.4%, respectively, resulting in a receiver operating characteristic with an area under the curve of 0.837. The absolute value of entropy had inverse correlation with stage 3.


CONCLUSIONS
Spectral entropy, which was calculated with Memcalc method, might be a possible index evaluating the quality of sleep.
Department of Clinical Laboratory, Tohoku University Hospital, Sendai 980-8574, Japan. bigkyu-thk@umin.ac.jp
Noriko
N
Ohisa
Hiromasa
H
Ogawa
Nobuki
N
Murayama
Katsumi
K
Yoshida
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004562:Electrocardiography; D019277:Entropy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000379:methods*; D012890:Sleep / Q000502:physiology*; D012891:Sleep Apnea Syndromes / Q000175:diagnosis* / Q000503:physiopathology*