How does intramolecular epitope spreading occur in BPAG2 (BP180)?
Several studies have suggested that autoantibodies directed against multiple epitopes occur via epitope spreading in autoimmune bullous skin diseases. However, the precise sequence of events in epitope spreading has not been elucidated for any of the epidermal autoantigens. In this issue, using a transgenic mouse model, Di Zenzo et al. report that intramolecular epitope spreading does occur for human BPAG2.
Hashimoto
Takashi
T
Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan. hashmot@med.kurume-u.ac.jp
Hamada
Takahiro
T
Dainichi
Teruki
T
Ishii
Norito
N
Karashima
Tadashi
T
Nakama
Takekuni
T
Yasumoto
Shinichiro
S
D000818:Animals; D001324:Autoantigens / Q000235:genetics* / Q000276:immunology*; D000939:Epitopes / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D024041:Non-Fibrillar Collagens / Q000235:genetics* / Q000276:immunology*; D000097805:Collagen Type XVII
D001324:Autoantigens; D000939:Epitopes; D024041:Non-Fibrillar Collagens; D000097805:Collagen Type XVII