Facile oxidation of electron-poor benzo[b]thiophenes to the corresponding sulfones with an aqueous solution of H2O2 and P2O5.
A facile oxidation for the clean conversion of benzo[b]thiophenes to their corresponding sulfones is described employing an aqueous solution of H(2)O(2) and P(2)O(5); the solution can be prepared and stored on a multi-gram scale with a shelf-life of up to two weeks.
Antonow
Dyeison
D
Cancer Research UK Protein-Protein Interactions Drug Discovery Research Group, The School of Pharmacy, University of London, 29-39 Brunswick Square, London, UK.
Marrafa
Teresa
T
Dawood
Irfaan
I
Ahmed
Tauheed
T
Haque
Mohammad R
MR
Thurston
David E
DE
Zinzalla
Giovanna
G
D004583:Electrons; D006861:Hydrogen Peroxide / Q000737:chemistry*; D010084:Oxidation-Reduction; D017553:Phosphorus Compounds / Q000737:chemistry*; D013450:Sulfones / Q000737:chemistry*; D013696:Temperature; D013876:Thiophenes / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D017553:Phosphorus Compounds; D013450:Sulfones; D013876:Thiophenes; D014867:Water; C088015:benzothiophene; C012500:phosphorus pentoxide; D006861:Hydrogen Peroxide