The transcription factor C/EBPβ is a marker of uterine receptivity and expressed at the implantation site in the primate.
During early pregnancy, the endometrium undergoes pronounced hormone-dependent functional changes in preparation for embryo implantation. Local autocrine-paracrine signaling at the fetal-maternal interface is crucial for the establishment of pregnancy. We previously reported that the transcription factor C/ EBPbeta, which is expressed at the implantation sites (ISs) in pregnant mice, acts as a key mediator of steroid hormone responsiveness in the endometrium. Mice lacking C/EBPbeta fail to support implantation due to defects in epithelial proliferation and stromal cell differentiation. In the current study, C/EBPbeta expression was dramatically stimulated in the endometrium of baboons (Papio anubis) during the window of uterine receptivity in response to a local infusion of chorionic gonadotropin, an embryonic signal. A robust induction of C/EBPbeta expression was also seen at the IS in the baboon and the human. Collectively, our results indicate that C/EBPbeta is a biomarker of endometrial receptivity and plays a conserved functional role during implantation in the primate.
Kannan
Athilakshmi
A
Department of Vet. Biosciences University of Illinois at Chicago, Chicago, IL, USA.
Fazleabas
Asgerally T
AT
Bagchi
Indrani C
IC
Bagchi
Milan K
MK
D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000378:metabolism*; D010064:Embryo Implantation / Q000502:physiology*; D004717:Endometrium / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D048530:Papio anubis / Q000378:metabolism*; D011247:Pregnancy; D014599:Uterus / Q000737:chemistry / Q000378:metabolism*
D015415:Biomarkers; D022782:CCAAT-Enhancer-Binding Protein-beta; C545012:CEBPB protein, human