[Expression and significance of PCNA and Caspase-3 in the tissue of lung cancer].
OBJECTIVE
To investigate the significance of PCNA and Caspase-3 in lung cancer.


METHODS
PCNA and Caspase-3 in 80 patients diagnosed with lung cancer were semi-quantitatively analyzed by using SP immunohistochemical staining.


RESULTS
The positive rate of Caspase-3 and PCNA were 32.5% and 65%, respectively. Both were much lower or higher than those normal lung tissues (P<0.05). Caspase-3 protein was correlated to lymph node metastasis, pathological type and differentiation grade (P<0.05). Meanwhile, PCNA was correlated to lymph node metastasis, differentiation grade and pathological staging of lung cancer (P<0.05), but not to pathological type. PCNA was negatively correlated to Caspase-3. PCNA (+)/Caspase-3(-) indicated the potential lower differentiation grade.


CONCLUSIONS
Up-regulation of PCNA and down-regulation of Caspase-3 are correlated to the pathological type, lymph node metastasis, staging and differentiation grade in lung cancer, especially which is indicating its clinical treatment.
Zhao
Yang
Y
Department of Thoracic Oncosurgery, the First Affiliated Hospital to Xi'an Jiaotong University, Xi'an, China. szhaoy@126.com
Li
Xiao-jun
XJ
Sui
Xin
X
Tang
Xiao-jiang
XJ
Qin
Hong
H
Ren
Hong
H
D053148:Caspase 3 / Q000032:analysis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung / Q000737:chemistry; D008175:Lung Neoplasms / Q000737:chemistry* / Q000473:pathology; D008207:Lymphatic Metastasis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*
D018809:Proliferating Cell Nuclear Antigen; D053148:Caspase 3