Serum protein and enzyme levels in rats following administration of ethanolic leaf extract of Ageratum conyzoides (goat weed).
The The potential hepatotoxic effects following oral administration of ethanolic leaf extract of Ageratum conyzoides (goat weed) was investigated in albino Wistar rats. Twenty eight (28) adult male Wistar rats were uniformly divided into four groups of seven rats each. Group 1 served as control while groups 2, 3 and 4 were respectively gavaged with 200 mg/kg body weight, 400 mg/kg body weight and 600 mg/kg body weight of the extract daily for 21 days. At the end of treatments, animals were sacrificed, serum and liver tissues obtained for assay of total protein concentration and levels of ALT, AST and ALP. Results showed that treatment of rats with the respective doses of the extract did not significantly alter the serum and liver levels of total protein, ALT, AST and ALP in all test groups. This result suggests that ingestion of the extract may not be toxic at the doses investigated.
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Department of Physiology, College of Medical Sciences, University of Calabar, Calabar, Nigeria.
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D000284:Administration, Oral; D031163:Ageratum; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000737:chemistry; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D018515:Plant Leaves; D028321:Plant Preparations / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000737:chemistry
D015415:Biomarkers; D001798:Blood Proteins; D028321:Plant Preparations; D012997:Solvents; D000431:Ethanol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase