TGN golgins, Rabs and cytoskeleton: regulating the Golgi trafficking highways.
The architecture of the Golgi apparatus is intimately linked to its role in regulating membrane trafficking. The recruitment of peripheral membrane proteins, in particular golgins and small G proteins has emerged as a key to the understanding of the organization and the dynamics of this organelle. There have been considerable recent advances in defining the structures and binding partners of golgins, and their contribution to membrane-mediated biological processes. In this paper, we review the proposed roles for golgins with a focus on the golgins of the trans-Golgi network (TGN). We explore the potential for TGN golgins, acting as scaffold molecules, to co-ordinate the regulation of TGN structure and function.
Goud
Bruno
B
Institut Curie, CNRS UMR144, 26, rue d'Ulm, Paris cedex 75248, France.
Gleeson
Paul A
PA
D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism*; D006056:Golgi Apparatus / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D021381:Protein Transport; D020691:rab GTP-Binding Proteins / Q000378:metabolism*
D008565:Membrane Proteins; D020691:rab GTP-Binding Proteins