[Two cases of MPO-ANCA-positive otitis media associated with facial palsy].
We report two cases of otitis media positive for antimyeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) associated with facial palsy. Case 1: A 73-year-old man treated for 3 months for bilateral otitis media with effusion had left facial nerve palsy and deteriorated bone conduction hearing in both ears. Blood analysis showed elevated MPO-ANCA to 134 EU. Case 2: A 66-year-old woman treated for about one year for bilateral otitis media with effusion and fluctuating mixed hearing loss had bilateral facial nerve palsy and a blood test positive for MPO-ANCA at 67 EU. Both were diagnosed with otitis media caused by ANCA-related vasculitis. After prednisolone and cyclophosphamide administration for half a year, blood test results were negative for MPO-ANCA. Both recovered almost completely from facial nerve palsy and bone conductive hearing loss partially improved except in one hearing-impaired ear. ANCA-related vasculitis of the temporal bone should thus be considered in those with intractable otitis media and deteriorated bone conduction hearing before the occurrence of facial palsy.
Jichi Medical University Saitama Medical Center, Saitama.
Hajime
H
Usubuchi
Kozue
K
Kodama
Katsumi
K
Takizawa
Takeharu
T
Kanazawa
Yasushi
Y
Ohta
Keiko
K
Kakizaki
Yukiko
Y
Iino
D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D005158:Facial Paralysis / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D010033:Otitis Media / Q000150:complications / Q000276:immunology*; D009195:Peroxidase / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase