First successful pregnancy after addition of enoxaparin to sildenafil and etanercept immunotherapy in woman with fifteen failed IVF cycles - case report.
OBJECTIVE
Does addition of enoxaparin to sildenafil and etanercept immunotherapy improve IVF outcome?


METHODS
Report of a striking case with 15 IVF failures.


RESULTS
When enoxaparin was added, the 16th IVF cycle generated a healthy male baby.


CONCLUSIONS
Combination therapy that includes a heparin may allow successful IVF outcome and this issue merits further study.
Department of Gynecology and Gynecological Oncology, Military Institute of Health Services, Warsaw, Poland. mmjerzak@wp.pl
Małgorzata
M
Jerzak
Tomasz
T
Niemiec
Anna
A
Nowakowska
Monika
M
Klochowicz
Andrzej
A
Górski
Włodzimierz
W
Baranowski
D000925:Anticoagulants / Q000627:therapeutic use*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004359:Drug Therapy, Combination; D004715:Endometriosis / Q000188:drug therapy / Q000276:immunology; D017984:Enoxaparin / Q000627:therapeutic use*; D000068800:Etanercept; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007167:Immunotherapy / Q000379:methods*; D007694:Killer Cells, Natural / Q000187:drug effects; D050498:Live Birth; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications; D011687:Purines / Q000627:therapeutic use; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000627:therapeutic use*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D000925:Anticoagulants; D017984:Enoxaparin; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D010879:Piperazines; D011687:Purines; D018124:Receptors, Tumor Necrosis Factor; D013450:Sulfones; D014409:Tumor Necrosis Factor-alpha; D000068677:Sildenafil Citrate; D000068800:Etanercept