Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery.
Biodegradable implants of ciprofloxacin hydrochloride for post operative site delivery were prepared using glyceryl monostearate and different concentrations of polyethylene glycol (PEG 6000), glycerol and Tween 80 as erosion enhancers by compression and molding technique. Formulations were subjected to in vitro drug release by the USP dissolution method, while promising formulations were subjected to in vitro drug release by the agar gel method and also to stability studies. It was observed that glyceryl monostearate formed hydrophobic matrix and delayed the drug delivery. Antibiotic release profile was controlled by using different combinations of erosion enhancers. The formulation prepared by the compression method showed more delayed release compared to formulations prepared by the molding method.
Mathur
Vijay
V
Sharad Pawar College of Pharmacy, Wanadongri, Nagpur-441110 (M.S.), India. mathurvb@gmail.com
Mudnaik
Rajesh
R
Barde
Laxmikant
L
Roy
Arghya
A
Shivhare
Umesh
U
Bhusari
Kishore
K
D020341:Absorbable Implants; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000138:chemical synthesis / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D016503:Drug Delivery Systems / Q000379:methods*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004355:Drug Stability; D011183:Postoperative Complications / Q000382:microbiology / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D003692:Delayed-Action Preparations; D002939:Ciprofloxacin