Design and synthesis of new amino-modified iminocyclitols: selective inhibitors of alpha-galactosidase.
A new and short synthesis of hitherto unreported stereo analogue of amino-modified five-membered iminocyclitols from readily available tri-O-benzyl-D-glucal is described. Significantly, glycosidase inhibition studies of alkylamino substituted iminocyclitols display a high degree of selectivity towards alpha-galactosidase.
Department of Chemistry, Indian Institute of Technology-Delhi, Hauz Khas, New Delhi, 110016, India.
Muthupandian
M
Ganesan
Rekhawar V
RV
Madhukarrao
Namakkal G
NG
Ramesh
D040503:Coffea / Q000201:enzymology; D054812:Cyclitols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology; D007097:Imines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D027861:Prunus / Q000201:enzymology; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D000519:alpha-Galactosidase / Q000037:antagonists & inhibitors* / Q000378:metabolism
D054812:Cyclitols; D007097:Imines; D000519:alpha-Galactosidase