A highly selective ratiometric fluorescent probe for 1,4-dithiothreitol (DTT) detection.
A highly selective ratiometric fluorescent probe, which contains an aminonaphthalimide fluorophore and a self-immolative spacer for 1,4-dithiothreitol (DTT) detection was designed and synthesized. The probe displays a 66 nm red-shift of fluorescence emission and the color changes from colorless to jade-green upon reaction with DTT. These properties are mechanistically ascribed to the strong reducing capability of DTT.
Department of Chemistry, School of Science, Beijing Institute of Technology, Beijing 100081, P. R. China.
Baocun
B
Zhu
Xiaoling
X
Zhang
Hongying
H
Jia
Yamin
Y
Li
Haipeng
H
Liu
Weihong
W
Tan
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D004229:Dithiothreitol / Q000032:analysis*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction; D010797:Phthalimides / Q000138:chemical synthesis / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
D000588:Amines; D005456:Fluorescent Dyes; D010797:Phthalimides; C037431:phthalimide; D004229:Dithiothreitol