Megakaryocytic blast crisis at presentation in a pediatric patient with chronic myeloid leukemia.
Patients with chronic myeloid leukemia (CML) infrequently present in blast crisis (BC). While most BC are of myeloid origin, megakaryocytic BC is rare, especially at the time of CML diagnosis. We describe the first pediatric patient presenting with megakaryocytic leukemia and having BCR-ABL1 translocation as the single chromosomal abnormality. Clinical features were more suggestive of CML in megakaryocytic blast crisis than Philadelphia chromosome positive de novo AML. The patient was treated with AML-directed chemotherapy and imatinib mesylate followed by umbilical cord blood stem cell transplantation. The patient was in complete molecular response 16 months after stem cell transplantation.
Department of Pediatric Hematology/Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
Ali
A
Al-Shehri
Amal
A
Al-Seraihy
Tarek M
TM
Owaidah
Asim F
AF
Belgaumi
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D001752:Blast Crisis / Q000473:pathology*; D002648:Child; D036101:Cord Blood Stem Cell Transplantation; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D000068877:Imatinib Mesylate; D007947:Leukemia, Megakaryoblastic, Acute / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D008533:Megakaryocytes / Q000473:pathology*; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D012074:Remission Induction; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate