[Association between Helicobacter pylori infection and gastroduodenal lesions in patients with chronic liver disease].
BACKGROUND
The relationship between Helicobacter pylori infection and gastroduodenal lesions in chronic liver disease remains controversial.


OBJECTIVE
Evaluate the evidence of the role of H. pylori infection in gastroduodenal lesions in patients with chronic liver disease.


METHODS
Forty-six patients with chronic liver disease were matched with 27 dyspeptic persons for age and sex. The gastroduodenal lesions were portal hypertension gastropathy, erosion and peptic ulcer. All patients underwent upper endoscopy: two biopsies were taken in the antrum and in the gastric body. The biopsies were used for Giemsa staining.


RESULTS
A gastroduodenal lesions were found in 38 (82.6%) patients with liver disease and was significantly more frequent than among controls (P = 0.002). H. pylori infection was detected at histological assessment in 13 (28.2%) patients with chronic liver disease and in 17 (62.9%) controls. The odds ratio (OR) showed an interaction statistically significant between gastroduodenal lesions and chronic liver disease (P = 0.04; OR = 5.1; 95% CI = 1.6-17.3). When adjusted for the presence of H. pylori OR was significantly with H. pylori negative (OR 13.0 IC 95%, 1.4-327.9).


CONCLUSIONS
Patients with chronic liver disease showed higher risk of developing gastroduodenal lesions regardless of the presence of the H. pylori infection.
Departamento de Clínica Médica, Hospital Universitário Professor Alberto Antunes, Universidade Federal de Alagoas, Maceió, AL. rozangelaw@yahoo.com.br
Rozangela Maria de Almeida Fernandes
RM
Wyszomirska
Laércio Tenório
LT
Ribeiro
Jackellyne Santos
JS
Monteiro
Bruno Pontes de Miranda
BP
Vidal
Roberta Maria Pereira Albuquerque de
RM
Melo
Cláudio Torres
CT
Miranda
D000328:Adult; D001706:Biopsy; D016022:Case-Control Studies; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology; D005767:Gastrointestinal Diseases / Q000382:microbiology*; D016481:Helicobacter Infections / Q000175:diagnosis / Q000209:etiology*; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology / Q000473:pathology; D008107:Liver Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged
Associação entre lesões da mucosa gastroduodenal e Helicobacter Pylori em pacientes com doença hepática crônica.