Successful unrelated donor cord blood transplantation for chronic granulomatous disease.
This report exemplified a success of unrelated donor cord blood transplantation (CBT) in a 4-month-old boy with chronic granulomatous disease (CGD). Following Bu14/Cy200/ATG conditioning, the patient received an HLA 2-locus-mismatched cord blood unit, and the total number of infused nucleated cells was 11.52 x 10(7)/kg. Neutrophil engraftment was achieved on day +13, and a platelet count greater than 20 x 10(9)/L was achieved on day +50. The neutrophil oxidative burst was 100% normal with full donor lymphocyte reconstitution at 8 months post-transplant. This case highlights that unrelated donor CBT for CGD is potentially safe and feasible, even in early infancy, when an appropriately matched related or unrelated donor is unavailable.
Jaing
Tang-Her
TH
Division of Hematology and Oncology, Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung University, Taoyuan, Taiwan.
Lee
Wen I
WI
Cheng
Po-Jen
PJ
Chen
Shih-Hsiang
SH
Huang
Jing-Long
JL
Soong
Yung-Kuei
YK
D036101:Cord Blood Stem Cell Transplantation; D006105:Granulomatous Disease, Chronic / Q000628:therapy*; D006648:Histocompatibility; D006801:Humans; D007223:Infant; D008297:Male; D009504:Neutrophils / Q000166:cytology / Q000502:physiology; D016897:Respiratory Burst / Q000502:physiology; D014019:Tissue Donors; D019172:Transplantation Conditioning / Q000379:methods; D016896:Treatment Outcome