Peeling skin syndrome: Current status.
Peeling Skin Syndrome (PSS) is a rare genodermatoses characterized by asymptomatic, localized or generalized, continuous exfoliation of the stratum corneum; it may present at birth or in adulthood. We describe a patient having the type A non-inflammatory variant of PSS showing asymptomatic and continuous skin peeling from the neck, trunk, back, and extremities. Friction appeared to be an aggravating factor, but there was no seasonal variation. Histopathology in this condition reveals hyperkeratosis and splitting of the epidermis between the granular layer and the stratum corneum. No treatment for this disorder has been found to be effective so far.
Postgraduate Department of Dermatology & STDs, Era's Lucknow Medical College & Hospital, Lucknow, India.
Kshitij
K
Garg
Devesh
D
Singh
Devesh
D
Mishra
D002648:Child; D005260:Female; D006720:Homozygote; D006801:Humans; D017488:Hyperkeratosis, Epidermolytic / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D007019:Hypoproteinemia / Q000473:pathology; D007073:Immunoglobulin E / Q000097:blood; D020125:Mutation, Missense / Q000235:genetics; D013577:Syndrome; D011503:Transglutaminases / Q000235:genetics
D007073:Immunoglobulin E; C418703:transglutaminase 5; D011503:Transglutaminases