Resveratrol and red wine, healthy heart and longevity.
Resveratrol, a polyphenol phytoalexin, present in red wine and grapes possesses diverse biochemical and physiological properties, including estrogenic, antiplatelet, and anti-inflammatory properties as well as a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, several studies described resveratrol as an anti-aging compound. This review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action, and emerging controversy on its life-prolonging ability. It appears that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice.
Cardiovacular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030-1110, USA. ddas@neuron.uchc.edu
Dipak K
DK
Das
Subhendu
S
Mukherjee
Diptarka
D
Ray
D000375:Aging / Q000187:drug effects*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D016587:Antimutagenic Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000737:chemistry / Q000494:pharmacology; D018890:Chemoprevention; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008136:Longevity / Q000187:drug effects*; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology; D059808:Polyphenols; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*; D014920:Wine
D000893:Anti-Inflammatory Agents; D016587:Antimutagenic Agents; D000975:Antioxidants; D002316:Cardiotonic Agents; D005419:Flavonoids; D010636:Phenols; D010975:Platelet Aggregation Inhibitors; D059808:Polyphenols; D013267:Stilbenes; D000077185:Resveratrol