Remission of paroxysmal atrial fibrillation with iron reduction in haemophilia A.
Two male first cousins with mild haemophilia A had baseline factor VIII levels of 12-15% and experienced bleeding requiring coagulation factor infusion therapy with trauma and surgical procedures. Both the patients with haemophilia A also had electrocardiographically documented symptomatic paroxysmal atrial fibrillation (PAF) for several years that had become resistant to pharmacological suppression. Radiofrequency ablation was considered in both the cases but deferred considering refusal of consent by the patients to undergo the procedure. Remission of arrhythmias has been reported in patients with iron-overload syndromes. Body iron stores assessed by serum ferritin levels were elevated in both men but neither had the C282Y or H63D genes for haemochromatosis. Calibrated reduction of iron stores by serial phlebotomy, avoiding iron deficiency, was followed by remission of symptomatic PAF in both cases. Iron reduction may be an effective treatment for arrhythmias apart from the classic iron-overload syndromes and deserves further study particularly in patients with bleeding disorders who might be at risk for arrhythmias and other diseases of ageing.
Section of Hematology/Oncology, Department of Medicine, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA. leo.r.zacharski@dartmouth.edu
L R
LR
Zacharski
L
L
McKernan
M E
ME
Metzger
M G
MG
Malone
V
V
Samnotra
A
A
Bhargava
P R
PR
Steiner
C A
CA
Rauwerdink
D L
DL
Ornstein
C J
CJ
Cornell
D001281:Atrial Fibrillation / Q000209:etiology* / Q000628:therapy*; D005169:Factor VIII / Q000008:administration & dosage; D005293:Ferritins / Q000097:blood; D006467:Hemophilia A / Q000150:complications* / Q000628:therapy; D006801:Humans; D019190:Iron Overload / Q000150:complications* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D018962:Phlebotomy; D016896:Treatment Outcome
D005169:Factor VIII; D005293:Ferritins