Enzymatic degradation of supramolecular materials based on partial inclusion complex formation between alpha-cyclodextrin and poly(epsilon-caprolactone).
Supramolecular biomaterials were prepared based on the formation of partial inclusion complexes between alpha-CD and poly(epsilon-caprolactone) (PCL). Enzyme-catalyzed degradation of these partial alpha-CD-PCL inclusion complexes was investigated at 37 degrees C in the presence of lipase from pancreas porcine. The biodegradation behaviors were monitored by weight loss measurement, (1)H NMR, XRD, GPC, DSC, and SEM. It was found that the formation of inclusion segments significantly accelerated the degradation of materials. A mechanism of enzymatic degradation for partial alpha-CD-PCL inclusion complexes was proposed. The present study provides a preliminary understanding for the biodegradation of the materials constructed by self-assembly between cyclodextrin and polymers.
Luo
Haiya
H
State Key Laboratory of Polymer Materials Engineering (Sichuan University), Polymer Research Institute of Sichuan University, Chengdu 610065, People's Republic of China.
Meng
Xianwei
X
Cheng
Cong
C
Dong
Zhenqiang
Z
Zhang
Sheng
S
Li
Bangjing
B
D002152:Calorimetry, Differential Scanning; D003460:Crystallization; D008049:Lipase / Q000737:chemistry / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D011091:Polyesters / Q000737:chemistry*; D014961:X-Ray Diffraction; D047391:alpha-Cyclodextrins / Q000737:chemistry*
D011091:Polyesters; D047391:alpha-Cyclodextrins; C016240:polycaprolactone; D008049:Lipase; C032613:alpha-cyclodextrin