[The protective effect of the arginine-heparin complex under simulation of insulin-dependent diabetes].
Daily intramuscular injections of the arginine-heparin complex for 5 days before injection of diabetogenic metabolite alloxan did not cause insulin-dependent diabetes in animals for 3 weeks. As a result of these injections, the anticoagulant fibrinolytic pattern of the anticoagulant system was activated and the platelet aggregation decreased. This effect held for 7 days after injection.
Ul'ianov
A M
AM
Obergan
T Iu
TIu
Shubina
T A
TA
Pastorova
V E
VE
Liapina
L A
LA
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D001120:Arginine / Q000494:pharmacology*; D003921:Diabetes Mellitus, Experimental / Q000517:prevention & control*; D005342:Fibrinolysis / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology*; D008297:Male; D015539:Platelet Activation / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D000925:Anticoagulants; D006493:Heparin; D001120:Arginine