5-Isopropylidene-3-ethyl rhodanine induce growth inhibition followed by apoptosis in leukemia cells.
5-Isopropylidene-3-ethyl rhodanine II was prepared by conventional and Microwave assisted synthesis. For the first time, we found that rhodanine II treatment led to cytotoxicity in leukemic cell line, CEM by inducing apoptosis.
Ravi
Subban
S
Department of Chemistry, Karpagam University, Coimbatore 21, Tamilnadu, India. ravisubban@rediffmail.com
Chiruvella
Kishore K
KK
Rajesh
K
K
Prabhu
V
V
Raghavan
Sathees C
SC
D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005434:Flow Cytometry; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D012236:Rhodanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013997:Time Factors
C551368:5-isopropylidene-3-ethyl rhodanine; D012236:Rhodanine