Evaluation of the biocompatibility of novel peptide hydrogel in rabbit eye.
A peptide containing a RGD (arginine-glycine-aspartic acid) sequence as well as a hydrophobic N-fluorenyl-9-methoxycarbonyl (FMOC) tail was prepared via a standard FMOC solid-phase peptide synthesis technique. The supramolecular self-assembly of such peptide through pi-pi stacking from FMOC tail can transfer the peptide aqueous solution into a three-dimensional hydrogel. The biocompatibility of the peptide hydrogel was evaluated via clinical follow-up and histological analysis. The data obtained demonstrated that the peptide hydrogel exhibited good biocompatibility when injected to the subconjunctival space and anterior chamber of rabbit, indicating a potential application in ophthalmology as an implantable drug delivery system for the treatment to ocular anterior segment diseases such as glaucoma, iridocyclitis, and keratopathy.
Liang
Liang
L
Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Xu
Xiao-Ding
XD
Chen
Chang-Sheng
CS
Fang
Jia-Hua
JH
Jiang
Fa-Gang
FG
Zhang
Xian-Zheng
XZ
Zhuo
Ren-Xi
RX
D000818:Animals; D005123:Eye; D020100:Hydrogels / Q000138:chemical synthesis / Q000494:pharmacology*; D015918:Infusion Pumps, Implantable; D008422:Materials Testing; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D011817:Rabbits
D020100:Hydrogels; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid