Locked nucleic acids: promising nucleic acid analogs for therapeutic applications.
Locked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides. The remarkable properties exhibited by LNA oligonucleotides have been employed in different nucleic acid-based therapeutic strategies both in vitro and in vivo. Herein, we highlight the applications of LNA nucleotides for controlling gene expression.
Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M. rnv@ifk.sdu.dk
Rakesh N
RN
Veedu
Jesper
J
Wengel
D052157:Aptamers, Nucleotide / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D021881:DNA, Catalytic / Q000737:chemistry / Q000378:metabolism; D035683:MicroRNAs / Q000737:chemistry / Q000378:metabolism; D009841:Oligonucleotides / Q000737:chemistry* / Q000627:therapeutic use; D016376:Oligonucleotides, Antisense / Q000737:chemistry; D018075:RNA, Complementary / Q000737:chemistry; D034741:RNA, Small Interfering / Q000737:chemistry / Q000378:metabolism
D052157:Aptamers, Nucleotide; D021881:DNA, Catalytic; D035683:MicroRNAs; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; D018075:RNA, Complementary; D034741:RNA, Small Interfering; C477371:locked nucleic acid; D004247:DNA