Polymer-peptide chimeras for the multivalent display of immunogenic peptides.
Chimeras of poly(n-isopropyl acrylamide) and immunogenic peptides from the cancer-associated glycoprotein MUC1 were synthesised using a combination of solid-phase peptide synthesis, RAFT polymerisation and copper-catalysed alkyne-azide cycloaddition reactions.
Kakwere
Hamilton
H
Key Center for Polymers and Colloids, School of Chemistry, University of Sydney, NSW 2006, Sydney, Australia.
Chun
Candy K Y
CK
Jolliffe
Katrina A
KA
Payne
Richard J
RJ
Perrier
Sébastien
S
D000178:Acrylamides / Q000737:chemistry*; D000180:Acrylic Resins; D000480:Alkynes / Q000737:chemistry; D000595:Amino Acid Sequence; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D018396:Mucin-1 / Q000737:chemistry / Q000276:immunology; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000276:immunology*; D011108:Polymers / Q000737:chemistry*
D000178:Acrylamides; D000180:Acrylic Resins; D000480:Alkynes; D001386:Azides; D018396:Mucin-1; D010455:Peptides; D011108:Polymers; C052970:poly-N-isopropylacrylamide; D003300:Copper