Indigenous case of disseminated histoplasmosis from the Penicillium marneffei endemic area of China.
This is the first indigenous case of disseminated histoplasmosis reported from the Penicillium marneffei endemic area in southern China. It was diagnosed by histopathology of tissue, gross and microscopic morphology of the culture and PCR assay of the isolated fungus. Successful antifungal treatment was with itraconazole 400 mg/day for 5 months. This case suggests that histoplasmosis should be an important differential diagnosis in immunocompromised patients in southern China and South East Asia (the only endemic area for P. marneffei).
Cao
Cunwei
C
Department of Dermatology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Province, People's Republic of China. caocunwei@yeah.net
Bulmer
Glenn
G
Li
Jushang
J
Liang
Ling
L
Lin
Youkun
Y
Xu
Yongjia
Y
Luo
Qinghua
Q
D000328:Adult; D002681:China; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D005260:Female; D006658:Histoplasma / Q000166:cytology / Q000235:genetics / Q000302:isolation & purification*; D006660:Histoplasmosis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage; D008853:Microscopy; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D016896:Treatment Outcome
D004271:DNA, Fungal; D021903:DNA, Ribosomal Spacer; D017964:Itraconazole