Nanoliter plates--versatile tools for the screening of split-and-mix libraries on-bead and off-bead.
Nanoliter plates are versatile tools for the screening of split-and-mix libraries both on-bead and off-bead. The method was evaluated for the identification of hydrolytically active compounds and enzyme inhibitors.
Upert
Grégory
G
Department of Chemistry-University of Basel, St. Johanns-Ring 19, CH-4056 Basel, Switzerland.
Merten
Christoph A
CA
Wennemers
Helma
H
D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors / Q000378:metabolism; D020650:Combinatorial Chemistry Techniques; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D043942:Nanotubes / Q000737:chemistry*; D054852:Small Molecule Libraries; D001616:beta-Galactosidase / Q000037:antagonists & inhibitors / Q000378:metabolism
D004129:Dimethylpolysiloxanes; D004791:Enzyme Inhibitors; D005456:Fluorescent Dyes; D054852:Small Molecule Libraries; C013830:baysilon; D000469:Alkaline Phosphatase; D001616:beta-Galactosidase