Novel chromeno [2,3-b]-pyrimidine derivatives as potential anti-microbial agents.
An efficient, microwave irradiated synthesis of novel chromeno[2,3-b]-pyrimidine derivatives was carried out. 2-amino-3,4-dihydro-2H-chromene-3-carbonitrile was converted into imine using N,N-Dimethylacetaldehyde dimethylacetal to give the core intermediate, which was used for the preparation of chromenopyrimidine library, using acetic acid and different amine in microwave irradiation for 5 min. Structures of newly synthesized compounds were confirmed by spectral studies. Compound 6g was characterized by single crystal X-ray analysis. All the compounds were also screened for their anti-microbial activity. Few of the compounds are found to be potential antimicrobials.
Chemistry Department, Manipal Institute of Technology, Manipal, India.
U
U
Sankappa Rai
Arun M
AM
Isloor
Prakash
P
shetty
A M
AM
Vijesh
Nithin
N
Prabhu
Shrikrishna
S
Isloor
M
M
Thiageeswaran
Hoong-Kun
HK
Fun
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001578:Benzopyrans / Q000737:chemistry* / Q000494:pharmacology*; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*
D000890:Anti-Infective Agents; D001578:Benzopyrans; D011743:Pyrimidines; C550867:chromeno(2,3-b)-pyrimidine