Resveratrol and red wine, healthy heart and longevity.
Resveratrol, a polyphenol phytoalexin, present in red wine and grapes possesses diverse biochemical and physiological properties, including estrogenic, antiplatelet, and anti-inflammatory properties as well as a wide range of health benefits ranging from chemoprevention to cardioprotection. Recently, several studies described resveratrol as an anti-aging compound. This review focuses on the anti-aging aspects of resveratrol, the possible mechanisms of action, and emerging controversy on its life-prolonging ability. It appears that resveratrol can induce the expression of several longevity genes including Sirt1, Sirt3, Sirt4, FoxO1, Foxo3a and PBEF and prevent aging-related decline in cardiovascular function including cholesterol level and inflammatory response, but it is unable to affect actual survival or life span of mice.
Das
Dipak K
DK
Cardiovacular Research Center, University of Connecticut School of Medicine, Farmington, CT 06030-1110, USA. ddas@neuron.uchc.edu
Mukherjee
Subhendu
S
Ray
Diptarka
D
D000375:Aging / Q000187:drug effects*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D016587:Antimutagenic Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D002316:Cardiotonic Agents / Q000737:chemistry / Q000494:pharmacology; D018890:Chemoprevention; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D006321:Heart / Q000187:drug effects*; D006801:Humans; D008136:Longevity / Q000187:drug effects*; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology; D059808:Polyphenols; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*; D014920:Wine
D000893:Anti-Inflammatory Agents; D016587:Antimutagenic Agents; D000975:Antioxidants; D002316:Cardiotonic Agents; D005419:Flavonoids; D010636:Phenols; D010975:Platelet Aggregation Inhibitors; D059808:Polyphenols; D013267:Stilbenes; D000077185:Resveratrol