[Liver malignancy in a patient with Wilson's disease].
Hepatocellular carcinoma and other tumours of the liver are extremely rare in Wilson's disease. We report a patient who presented with a cholangiocarcinoma associated with Wilson's disease. The literature review underlines that patients with Wilson's disease should be considered at risk of hepatocellular carcinoma, cholangiocarcinoma and undifferentiated carcinoma in the liver. Risk factors seem to be long disease duration and probably a poor observance to therapy. A liver imaging should be included in the follow-up of patients with Wilson's disease.
Service d'hépatogastroentérologie, hôpital de la Croix-Rousse, 103, grande rue de la Croix-Rousse, 69317 Lyon cedex 04, France.
M
M
Pioche
A-M
AM
Marion-Audibert
C
C
Thevenet-d'Yvoire
A
A
Rode
B
B
Bancel
J-Y
JY
Mabrut
D
D
Pere-Verge
J-C
JC
Souquet
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001650:Bile Duct Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D017809:Fatal Outcome; D006527:Hepatolenticular Degeneration / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008297:Male; D012307:Risk Factors
Maladie de Wilson et tumeur hépatique maligne.