Bupropion toxicokinetic: a case report.
BACKGROUND
The toxicokinetics of sustained-release bupropion are not well described.


METHODS
A 23-year-old Caucasian male took an overdose of 5,700 mg of sustained release bupropion with no co-ingestant. Venous serum samples were assayed for bupropion concentrations over the next 5 days. The peak concentration was 1.114 mg/L. The observed T(max) was found to be 8.25 h, the calculated alpha half-life 10.9 h (+/-SE of 4.47%), and the calculated beta half-life 19.8 h (+/-SE 12.62%). The alpha half-life and T(max) differ significantly from those seen in therapeutic doses.


CONCLUSIONS
Bezoar formation may underlie these differences. Interventions which reduce the absorption of sustained release bupropion may be effective in overdose.
Donnelly
Kieran
K
Department of Anaesthetics, UHB NHS Trust, Sellyoak, Birmingham, UK. kdonnelly2@nhs.net <kdonnelly2@nhs.net>
Walkowiak
Hannah Beth
HB
Donnelly
Christopher
C
Jenkinson
Emma
E
Rizkalla
Jonha
J
Langford
Nigel
N
D000328:Adult; D000928:Antidepressive Agents / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D016642:Bupropion / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D003692:Delayed-Action Preparations / Q000493:pharmacokinetics / Q000506:poisoning; D062787:Drug Overdose / Q000097:blood; D006801:Humans; D008297:Male
D000928:Antidepressive Agents; D003692:Delayed-Action Preparations; D016642:Bupropion