Lithiation-electrophilic substitution of N-thiopivaloylazetidine.
The fourth protocol: the rarely studied N-thiopivaloyl group plays a crucial role in mediating efficient α lithiation and incorporation of diverse electrophiles onto an azetidine ring; in the presence of chiral ligands, this chemistry also provides the first example of an enantioselective electrophilic substitution on a four-membered ring.
Department of Chemistry, Chemistry Research Laboratory, Oxford, UK. david.hodgson@chem.ox.ac.uk
David M
DM
Hodgson
Johannes
J
Kloesges