Review article: the role of rapid virological response in determining treatment duration for chronic hepatitis C.
BACKGROUND
For patients with chronic hepatitis C, attaining rapid virological response (RVR) is highly predictive of attaining SVR.


OBJECTIVE
To consider the predictive value of RVR in terms of SVR and relapse.


METHODS
Data were collected from published clinical trials to define the predictive value of RVR for SVR and evaluate the proposed continuum linking RVR to relapse.


RESULTS
These data support a 24-week regimen among genotype (G)1 patients who attain RVR with positive predictive values (PPVs) of 77.8% and 85.7% in patients with G1 infection treated for 24 and 48 weeks. Conversely, failure to attain RVR among G1 patients should not be viewed as a criterion for extending treatment duration beyond 48 weeks: negative predictive values (NPVs) were 60.9% and 52.7% in G1 patients without RVR treated for 48 and 72 weeks. Among G2/3 patients, RVR has a high PPV; however, the NPV varied with treatment duration indicating that a 24-week treatment regimen is warranted in G2/3 patients who fail to attain RVR.


CONCLUSIONS
The present analysis confirms RVR as a strong predictor of SVR that can be used to tailor treatment duration, but which also should be appreciated in the context of treatment duration and regimen.
Hepatology and Liver Transplantation, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. Fred.Poordad@cshs.org
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Poordad
D000998:Antiviral Agents / Q000008:administration & dosage*; D002986:Clinical Trials as Topic; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D011237:Predictive Value of Tests; D012367:RNA, Viral / Q000097:blood; D013997:Time Factors; D016896:Treatment Outcome; D019562:Viral Load
D000998:Antiviral Agents; D012367:RNA, Viral