CD24 Ala57Val gene polymorphism and the risk of systemic lupus erythematosus.
It was recently shown that the CD24 Ala57Val (rs 52812045) polymorphism plays a significant role in susceptibility to systemic lupus erythematosus (SLE) in a Spanish population, which has not been confirmed in other ethnic groups. We investigated the distribution of the CD24 Ala57Val polymorphism in patients with SLE (n = 250) and controls (n = 350) in Poland. The odds ratio (OR) for patients with SLE with the Ala/Val genotype compared with Ala/Ala genotype was 1.490 [95% confidence interval (CI) = 1.052-2.111, P = 0.0275], and OR for the Val/Val genotype compared with Ala/Ala genotypes was 2.001 (95% CI = 1.154-3.467, P = 0.0154). Moreover, we observed a significant association between the CD24 Val allele and the presence of anti-Scl-70 antibody (Ab) OR = 2.155 (1.438-3.229, P = 0.0002). There was also an association of Val allele with the presence of anti-snRNP Ab OR = 1.984 (1.266-3.110, P = 0.0034) in patients with SLE. We also found that the CD24 Val/Val and Ala/Val genotypes contribute to immunologic manifestations OR = 2.244 (1.323-3.806, P = 0.0037). Our observations indicate that the CD24 Ala57Val polymorphism may predispose to SLE incidence and can be linked to immunologic manifestations and production of autoantibodies in this disease.
Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, Poznań, Poland.
P
P
Piotrowski
M
M
Lianeri
M
M
Wudarski
J K
JK
Łacki
P P
PP
Jagodziński
D000328:Adult; D000409:Alanine / Q000235:genetics; D019943:Amino Acid Substitution; D051927:CD24 Antigen / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008875:Middle Aged; D011044:Poland; D011110:Polymorphism, Genetic; D012306:Risk; D014633:Valine / Q000235:genetics
D051927:CD24 Antigen; D014633:Valine; D000409:Alanine