Is canalization more than just a beautiful idea?
The heat-shock protein 90 (Hsp90) is currently thought to buffer eukaryotic cells against perturbations caused by pre-existing cryptic genetic variation. A new study suggests that the buffering function of Hsp90 could instead be due to its repression of de novo transposon-mediated mutagenesis.
Sato
Kaoru
K
Department of Molecular Biology, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
Siomi
Haruhiko
H
D000818:Animals; D004251:DNA Transposable Elements / Q000502:physiology; D004330:Drosophila / Q000235:genetics; D014644:Genetic Variation; D018841:HSP90 Heat-Shock Proteins / Q000235:genetics / Q000502:physiology; D008957:Models, Genetic; D010641:Phenotype
D004251:DNA Transposable Elements; D018841:HSP90 Heat-Shock Proteins