Response to oxidative stress in eight pathogenic yeast species of the genus Candida.
In the course of an infection, the formation of reactive oxygen species by phagocytes and the antioxidant defense mechanisms of microorganisms play a crucial role in pathogenesis. In this study, isolates representing 8 pathogenic Candida species-Candida albicans, Candida dubliniensis, Candida famata, Candida glabrata, Candida guilliermondii, Candida krusei, Candida parapsilosis and Candida tropicalis-were compared with regard to their resistance to oxidative stress in vitro. We evaluated degree of resistance, induction of oxidative damage, capacity to adapt, and induction of antioxidant enzymes. The species showed variable sensitivity to oxidative attack. C. albicans, C. glabrata, and C. krusei were more resistant to oxidative stress under the conditions tested; C. parapsilosis and C. tropicalis presented medium resistance; and C. dubliniensis, C. famata, and C. guilliermondii were more sensitive. The overall greater resistance to oxidative stress of C. albicans and C. glabrata may provide an advantage to these species, which are the major causative agents of candidiasis.
Programa de Pós-Graduação em Biologia Celular e Molecular (PPGBCM), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.
Maxwel Adriano
MA
Abegg
Paulo Vinicius Gil
PV
Alabarse
Anderson
A
Casanova
Jaqueline
J
Hoscheid
Tiago Boeira
TB
Salomon
Fernanda Schäfer
FS
Hackenhaar
Tássia Machado
TM
Medeiros
Mara Silveira
MS
Benfato
D000975:Antioxidants / Q000502:physiology; D002175:Candida / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D050296:Microbial Viability / Q000187:drug effects; D016877:Oxidants / Q000633:toxicity*; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000633:toxicity; D013312:Stress, Physiological
D000975:Antioxidants; D016877:Oxidants; D017382:Reactive Oxygen Species