[Seroprevalence of HTLV-1/2 in blood donors from Misiones Province].
Human T-cell Lymphotropic viruses type 1 (HTLV-1), the first human oncoretrovirus to be discovered, is the etiologic agent of Adult T-cell Leukemia (ATL) and HTLV-1 Associated Mielopathy or Tropical Spastic Paraparesis (HAM/TSP). It is endemic worldwide, including the North of Argentina where both associated diseases have also been detected. No etiologic role has been described for HTLV-2, although it has been associated with HAM/TSP-like neurologic syndromes. Both retroviruses are endemic in native populations of The Americas, Africa and at-risk populations. They are transmitted through sex contact, parenterally and from mother to child. The aim of this study was to estimate the seroprevalence of HTLV-1/2 in a blood donor population from Misiones province. A total of 6912 accepted blood donations in 2008 were analyzed. HTLV-1/2 screening was performed with ELISA and particle agglutination, and reactive samples were confirmed by Western Blot. From the total, 5 samples resulted seropositive with a final prevalence of 0.00072. Out of the 5 positive samples, one was an HTLV, three HTLV-1 and one HTLV-2. These blood donors were residents of Posadas, Eldorado and Oberá, with no risk antecedents. This study demonstrates the presence of HTLV-1/2 in a population of Misiones with a prevalence rate similar to those reported among blood donors from non-endemic areas.
Malan
Richard
R
Banco de Sangre Central de la Provincia de Misiones, Posadas.
Berini
Carolina A
CA
Eirin
María E
ME
Delfino
Cecilia M
CM
Pedrozo
Williams
W
Krupp
Ramón
R
García Plichta
Atilio
A
Biglione
Mirna M
MM
D000328:Adult; D001118:Argentina / Q000453:epidemiology; D001782:Blood Donors / Q000706:statistics & numerical data*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015490:HTLV-I Infections / Q000097:blood / Q000453:epidemiology*; D015491:HTLV-II Infections / Q000097:blood / Q000453:epidemiology*; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification; D015367:Human T-lymphotropic virus 2 / Q000302:isolation & purification; D006801:Humans; D008297:Male; D016036:Seroepidemiologic Studies
Seroprevalencia de HTLV-1/2 en donantes de sangre de la Provincia de Misiones.