Dural based primary osteosarcoma in right fronto-temporal region with review of literature.
We report a case of primary dural based osteosarcoma in the right fronto-temporal convexity in a 43-year-old female who presented with a short history of seizure and headache. Radiologic evaluation revealed a well defined brightly enhancing extra-axial lesion in the right fronto-temporal region with a dural tail around the sylvian fissure. The overlying bone was uninvolved. Paraffin section of the tumor showed plump cells with moderate nuclear and cellular pleomorphism with eosinophilic extracellular material (osteiod) between the cells. At a few places, lace like osteiod was seen encasing individual cells signifying osteiod being formed by tumor cells. Immunohistochemistry for EMA was focally positive and negative for S-100 protein and GFAP. A final histopathological diagnosis of dural based primary osteosarcoma of the right fronto-temporal region was rendered. To the best of our knowledge this will be the eighth such case in literature.
Department of Pathology and Transfusion Medicine, Sri Sathya Sai Institute of Higher Medical Sciences, Bangalore, India. nandita.g@rediffmail.com
Nandita
N
Ghosal
Ravi
R
Dadlani
Sunil V
SV
Furtado
Naman
N
Bagdi
A S
AS
Hegde
D000328:Adult; D001859:Bone Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D012516:Osteosarcoma / Q000378:metabolism / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism; D013702:Temporal Lobe / Q000473:pathology*
D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins