A compound herbal preparation (CHP) in the treatment of children with ADHD: a randomized controlled trial.
OBJECTIVE
Evaluation of the efficacy of a patented, compound herbal preparation (CHP) in improving attention, cognition, and impulse control in children with ADHD.


METHODS



METHODS
A randomized, double-blind, placebo-controlled trial.


METHODS
University-affiliated tertiary medical center.


METHODS
120 children newly diagnosed with ADHD, meeting DSM-IV criteria.


METHODS
Random assignment to the herbal treatment group (n = 80) or control group (placebo; n = 40); 73 patients in the treatment group (91%) and 19 in the control group (48%) completed the 4-month trial.


METHODS
Test of Variables of Attention (TOVA) administered before and after the treatment period; overall score and 4 subscales.


RESULTS
The treatment group showed substantial, statistically significant improvement in the 4 subscales and overall TOVA scores, compared with no improvement in the control group, which persisted in an intention-to-treat analysis.


CONCLUSIONS
The well-tolerated CHP demonstrated improved attention, cognition, and impulse control in the intervention group, indicating promise for ADHD treatment in children.
Katz
M
M
ADHD and Adaptation Clinic, Sheba Medical Center, Tel Hashomer, Israel.
Levine
A Adar
AA
Kol-Degani
H
H
Kav-Venaki
L
L
D000704:Analysis of Variance; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D034681:Bacopa; D028041:Centella; D002648:Child; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D029596:Paeonia; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D053545:Spirulina; D016896:Treatment Outcome; D032341:Withania
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts