Microwave-assisted derivatization procedures for gas chromatography/mass spectrometry analysis.
In this review, published applications of microwave-assisted derivatization procedures for gas chromatography/mass spectrometry (GC/MS) are summarized. Among the broad range of analytical techniques available, GC/MS is still the method of choice for most high-throughput screening procedures in forensic/clinical toxicology, doping control and food and environmental analysis. Despite the many advantages of the GC/MS method, time-consuming derivatization steps are often required in order to obtain desirable chromatographic characteristics or to improve the stability and detectability of the target analytes. These derivatization processes typically require reaction times from 30 min up to several hours at elevated temperature. In contrast, microwave protocols have demonstrated to be able to reduce the time required for derivatization to a few minutes, and can thus very effectively shorten the overall analysis time, in particular when carried out in a high-throughput format. Herein, the literature in this field is summarized and recent experimental techniques for performing parallel GC/MS derivatization protocols are discussed.
Söderholm
Sandra L
SL
Christian Doppler Laboratory for Microwave Chemistry (CDLMC), Institute of Chemistry, Karl-Franzens-University Graz, Heinrichstrasse 28, 8010, Graz, Austria.
Damm
Markus
M
Kappe
C Oliver
CO
D053000:Analytic Sample Preparation Methods / Q000379:methods*; D004355:Drug Stability; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods* / Q000639:trends; D057166:High-Throughput Screening Assays / Q000379:methods; D007287:Inorganic Chemicals / Q000737:chemistry / Q000494:pharmacology; D008872:Microwaves; D008954:Models, Biological; D009930:Organic Chemicals / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology
D007287:Inorganic Chemicals; D009930:Organic Chemicals