The role of PEDF in tumor growth and metastasis.
Pigment epithelium-derived factor (PEDF), one of the non-inhibitory serpines, is widely expressed throughout the body. Although PEDF was initially identified as a neuronal differentiation factor, more attention has been paid to its anti-angiogenic activity. Additionally, recent researches have demonstrated that PEDF has an anti-tumor effect against several human neoplasms. This review focuses on the pathological role of PEDF in tumors, especially tumor growth and metastasis. PEDF is an endogenous anti-tumor factor and its clinical application seems quite promising, although there is much to be further investigated.
Hoshina
D
D
Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan. hoshina@med.hokudai.ac.jp
Abe
R
R
Yamagishi
S-I
SI
Shimizu
H
H
D020533:Angiogenesis Inhibitors / Q000378:metabolism* / Q000627:therapeutic use; D017209:Apoptosis / Q000502:physiology; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D005136:Eye Proteins / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D009362:Neoplasm Metastasis / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D009414:Nerve Growth Factors / Q000378:metabolism* / Q000627:therapeutic use; D011480:Protease Inhibitors / Q000378:metabolism* / Q000627:therapeutic use; D015843:Serpins / Q000378:metabolism* / Q000627:therapeutic use; D015398:Signal Transduction / Q000502:physiology; D019014:fas Receptor / Q000378:metabolism; D000099174:Pigment Epithelium-Derived Factor
D020533:Angiogenesis Inhibitors; D005136:Eye Proteins; D009414:Nerve Growth Factors; D011480:Protease Inhibitors; D015843:Serpins; D019014:fas Receptor; D000099174:Pigment Epithelium-Derived Factor