3-Prenyl luteolin, a new prenylated flavone with melanin biosynthesis inhibitory activity from wood of Artocarpus heterophyllus.
In our efforts to find new whitening agent from natural resources, we focused on wood of Artocarpus heterophyllus which shows anti-melanogenesis activity. By activity-guided fractionation of A. heterophyllus wood extract, a new prenylated flavonoid, 3-prenyl luteolin (1) was isolated. The IC(50) of mushroom tyrosinase inhibitory activity of 1 was 76.3 microM. The results of the comparison with that of luteolin showed the prenyl substituent at C-3 position of 1 play an important role for revealing tyrosinase inhibition. In melanin formation inhibition on B16 melanoma cells, IC(50) of 1 was 56.7 microM with less cytotoxicity.
Department of Forest Products Technology, Faculty of Forestry, Mulawarman University, Samarinda, Indonesia.
Enos Tangke
ET
Arung
Kuniyoshi
K
Shimizu
Hiroyuki
H
Tanaka
Ryuichiro
R
Kondo
D000818:Animals; D031622:Artocarpus / Q000737:chemistry*; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D047311:Luteolin / Q000737:chemistry / Q000302:isolation & purification*; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D051379:Mice; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D010946:Plants, Medicinal / Q000737:chemistry; D014934:Wood / Q000737:chemistry
C553719:3-prenyl luteolin; D047309:Flavones; D008543:Melanins; D014442:Monophenol Monooxygenase; D047311:Luteolin