Electronic medical records as a research tool: evaluating topiramate use at a headache center.
BACKGROUND
Electronic medical records (EMRs) are used in large healthcare centers to increase efficiency and accuracy of documentation. These databases may be utilized for clinical research or to describe clinical practices such as medication usage.


METHODS
We conducted a retrospective analysis of EMR data from a headache clinic to evaluate clinician prescription use and dosing patterns of topiramate. The study cohort comprised 4833 unique de-identified records, which were used to determine topiramate dose and persistence of treatment.


RESULTS
Within the cohort, migraine was the most common headache diagnosis (n = 3753, 77.7%), followed by tension-type headache (n = 338, 7.0%) and cluster or trigeminal autonomic cephalalgias (n = 287, 5.9%). Physicians prescribed topiramate more often for subjects with migraine and idiopathic intracranial hypertension (P < .0001) than for those with other conditions, and more often for subjects with coexisting conditions including obesity, bipolar disorder, and depression. The most common maintenance dose of topiramate was 100 mg/day; however, approximately 15% of subjects received either less than 100 mg/day or more than 200 mg/day. More than a third of subjects were prescribed topiramate for more than 1 year, and subjects with a diagnosis of migraine were prescribed topiramate for a longer period of time than those without migraine.


CONCLUSIONS
Findings from our study using EMR demonstrate that physicians use topiramate at many different doses and for many off-label indications. This analysis provided important insight into our patient populations and treatment patterns.
Marmura
Michael J
MJ
From the Jefferson Headache Center, Philadelphia, PA, USA.
Hopkins
Mary
M
Andrel
Jocelyn
J
Young
William B
WB
Biondi
David M
DM
Rupnow
Marcia F T
MF
Armstrong
Robert B
RB
D000328:Adult; D000700:Analgesics / Q000008:administration & dosage; D000927:Anticonvulsants / Q000008:administration & dosage; D015331:Cohort Studies; D011307:Drug Prescriptions / Q000592:standards*; D057286:Electronic Health Records / Q000592:standards*; D005260:Female; D005632:Fructose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D020773:Headache Disorders / Q000145:classification / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010818:Practice Patterns, Physicians' / Q000639:trends*; D012189:Retrospective Studies; D000077236:Topiramate
D000700:Analgesics; D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose