Inhibitory effect of the flowers of artichoke (Cynara cardunculus) on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin.
The methanol extract of the flowers of artichoke (Cynara cardunculus) exhibited remarkable antitumor activity in an in vivo two-stage carcinogenesis test in mice, using 7,12-dimethylbenz[a]anthracene as an initiator and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter. From the active fraction of the methanol extract, four triterpene alcohols and their corresponding acetates were isolated and identified. These compounds were evaluated for their inhibitory effects on TPA-induced inflammation (1 microg/ear) in mice and showed marked anti-inflammatory effects, with a 50% inhibitory dose of 0.50-0.91 micromol/ear.
College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan. yasukawa.ken@nihon-u.ac.jp
Ken
K
Yasukawa
Hideki
H
Matsubara
Yuri
Y
Sano
D000085:Acetates / Q000737:chemistry / Q000627:therapeutic use; D000438:Alcohols / Q000737:chemistry / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000627:therapeutic use*; D031943:Cynara scolymus / Q000737:chemistry*; D005260:Female; D035264:Flowers / Q000737:chemistry*; D007249:Inflammation / Q000139:chemically induced* / Q000188:drug therapy*; D051379:Mice; D008813:Mice, Inbred ICR; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity*; D014315:Triterpenes / Q000737:chemistry / Q000627:therapeutic use
D000085:Acetates; D000438:Alcohols; D000893:Anti-Inflammatory Agents; D014315:Triterpenes; D013755:Tetradecanoylphorbol Acetate