Differential division rates and size control in the wing disc.
We have generated wing disc compartments that contain marked fast growing M+ clones surrounded by slow dividing M/+ cells. Under these conditions the interactions between fast and slow dividing cells at the clone borders frequently lead to cell competition. However, our assay suppressing apoptosis indicates that cell competition plays no major role in size control. We argue that cells within a compartment proliferate according to their genotype independently of each other and that their contribution to the final structure will depend solely on their proliferation rate. This model is supported by a computer simulation that predicts values similar to those found experimentally. Our results on the growth of M+ clones within compartments and on the expression of developmental genes like vestigial and wingless suggest the existence of a non-cell autonomous mechanism that functions at the level of the entire cell population. It measures the population size in each moment, determines the corresponding expression levels of developmental genes and establishes the time to arrest growth.
Centro de Biología Molecular, CSIC-UAM, Madrid, Spain. gmorata@cbm.uam.es
Gines
G
Morata
Salvador C
SC
Herrera
D000818:Animals; D002455:Cell Division; D048429:Cell Size; D002999:Clone Cells / Q000502:physiology; D003198:Computer Simulation; D004330:Drosophila / Q000235:genetics / Q000254:growth & development*; D060227:Imaginal Discs / Q000502:physiology*; D008675:Metamorphosis, Biological; D008954:Models, Biological; D014921:Wings, Animal / Q000254:growth & development*