[Role of histamine in atherosclerotic lesions].
Histamine is synthesized from L-histidine by histidine decarboxylase and is involved in a variety of physiologic responses, such as inflammation, type I allergy, gastric acid secretion and neurotransmission. In the arteriosclerotic lesions, histamine produced by macrophage-derived foam cells acts on smooth muscle cells, endocrine cells and inflammation cells through the specific histamine receptors and regulates the expression of many molecules concerned with inflammatory reaction. A regulatory system of chronic inflammatory reaction by the histamine network is involved in the formation and development of arteriosclerosis.
Wang
Ke-Yong
KY
Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Japan.
Tanimoto
Akihide
A
Sasaguri
Yasuyuki
Y
D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology*; D006632:Histamine / Q000502:physiology*; D006801:Humans
D006632:Histamine