A case of canine lymphomatoid granulomatosis with cutaneous lesions.
A 10-year-old, castrated, mixed-breed dog presented with a 1.5-month history of scattered, crateriform ulcers on the trunk and extremities. Some skin lesions appeared to regress spontaneously, but new lesions developed. Thoracic radiography revealed pulmonary consolidated lesions suggestive of tumor. A skin biopsy was performed for histopathological, immunohistochemical and clonality analyses. Histopathological examination of the cutaneous lesion revealed an intense infiltration of atypical lymphoid cells with some other cell populations around the blood vessels in the dermis. Atypical lymphoid cells were shown to be CD3-positive in the immunohistochemical analysis. The presence of clonally expanded T-cells was revealed by the clonal rearrangement of T-cell receptor gamma-chain gene. From the above findings, the dog was diagnosed with lymphomatoid granulomatosis.
Noya Animal Hospital, Saitama, Japan. shima55@h2.dion.ne.jp
Toru
T
Shimazaki
Masahiko
M
Nagata
Yuko
Y
Goto-Koshino
Hajime
H
Tsujimoto
Kinji
K
Shirota
D000818:Animals; D001706:Biopsy / Q000662:veterinary; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000235:genetics / Q000473:pathology; D004285:Dogs; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006801:Humans; D008230:Lymphomatoid Granulomatosis / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D008297:Male; D009919:Orchiectomy; D012871:Skin Diseases / Q000235:genetics / Q000473:pathology / Q000662:veterinary*