Visual loss associated with tacrolimus: case report and review of the literature.
Tacrolimus is an immunosuppressive medication in the class of calcineurin inhibitors that acts by inhibiting T-cell and interleukin-2 activity, and is commonly used after allogeneic organ transplant. We present a patient who used tacrolimus after cadaveric kidney transplant and experienced blurry vision. Ocular examination and patient's course subsequently revealed aqueous tear deficiency as a dose-dependent adverse effect of oral tacrolimus.
Kapoor
Kapil G
KG
Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch at Galveston, 77550, USA. kgkapoor@utmb.edu <kgkapoor@utmb.edu>
Mirza
Sarah N
SN
Gonzales
John A
JA
Gibran
Syed K
SK
D015352:Dry Eye Syndromes / Q000139:chemically induced / Q000188:drug therapy; D005922:Glomerulonephritis, IGA / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation; D007766:Lacrimal Apparatus Diseases / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D016559:Tacrolimus / Q000009:adverse effects*; D014786:Vision Disorders / Q000139:chemically induced* / Q000188:drug therapy; D014792:Visual Acuity
D007166:Immunosuppressive Agents; D009883:Ophthalmic Solutions; D016559:Tacrolimus