Cdc25A and Dub3 in a high-stakes balancing act.
The deubiquitylating enzyme Dub3 is found to have oncogenic potential by stabilizing the Cdc25A protein phosphatase, a crucial regulator of cell-cycle progression.
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Sebastian D
SD
Hayes
J Wade
JW
Harper
D000818:Animals; D017209:Apoptosis; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D002453:Cell Cycle; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism*; D004249:DNA Damage; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism*; D004795:Enzyme Stability; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016259:Genes, myc; D011905:Genes, ras; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D054875:Ubiquitination; D020687:cdc25 Phosphatases / Q000235:genetics / Q000378:metabolism*
C517004:CDC25A protein, human; D020687:cdc25 Phosphatases; D010450:Endopeptidases; C484854:USP17L2 protein, human; D046988:Proteasome Endopeptidase Complex