Missed brown tumors in a young adult with decreased bone density.
Brown tumors, a benign osteolytic process, are most commonly caused by hyperparathyroidism. Multiple bone involvement is relatively rare. There are many similarities in the radiologic and histological features of brown tumors and giant cell tumors (GCTs) of bone. Differentiation between the two lesions is dependent upon evaluation of serum biochemistry including serum calcium, phosphorous, and intact parathyroid hormone (I-PTH) levels. Herein, the case of a 32-year-old man with multiple osteolytic lesions of the left tibia and fibula as well as the fourth metacarpal bone of the left hand, previously misdiagnosed with multiple GCTs, is presented. Based on the radiographic findings and biochemistry results in a young adult patient, brown tumor was suspected and subsequently definitively diagnosed.
Kao
Hao-Lun
HL
Department of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Chang
Wei-Chou
WC
Lee
Chian-Her
CH
Lee
Herng-Sheng
HS
Huang
Guo-Shu
GS
D000328:Adult; D001851:Bone Diseases, Metabolic / Q000209:etiology; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005360:Fibula / Q000473:pathology; D018212:Giant Cell Tumor of Bone / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D049950:Hyperparathyroidism, Primary / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D008297:Male; D010002:Osteitis Fibrosa Cystica / Q000175:diagnosis* / Q000473:pathology; D010014:Osteolysis / Q000175:diagnosis / Q000473:pathology; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D016105:Parathyroidectomy; D013977:Tibia / Q000473:pathology
D010281:Parathyroid Hormone