A highly selective ratiometric fluorescent probe for 1,4-dithiothreitol (DTT) detection.
A highly selective ratiometric fluorescent probe, which contains an aminonaphthalimide fluorophore and a self-immolative spacer for 1,4-dithiothreitol (DTT) detection was designed and synthesized. The probe displays a 66 nm red-shift of fluorescence emission and the color changes from colorless to jade-green upon reaction with DTT. These properties are mechanistically ascribed to the strong reducing capability of DTT.
Zhu
Baocun
B
Department of Chemistry, School of Science, Beijing Institute of Technology, Beijing 100081, P. R. China.
Zhang
Xiaoling
X
Jia
Hongying
H
Li
Yamin
Y
Liu
Haipeng
H
Tan
Weihong
W
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D004229:Dithiothreitol / Q000032:analysis*; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction; D010797:Phthalimides / Q000138:chemical synthesis / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
D000588:Amines; D005456:Fluorescent Dyes; D010797:Phthalimides; C037431:phthalimide; D004229:Dithiothreitol