The role of fibrinogen in aggregation of platelets in burn injury.
Spontaneous aggregation of platelets is considerably enhanced in the acute period after burn. The changes in indices-induced aggregation of platelets are non-uniform and not significant statistically. Thermal trauma is accompanied by the development of hyperfibrinogenemia and an increase in the level of oxidised fibrinogen. We studied the influence of fibrinogen concentration and the degree of its oxidation on aggregation of platelets. It was shown that the level of aggregation of platelets greatly depends on the concentration of fibrinogen (non-oxidised and oxidised) plasma. The possible mechanisms of these effects are investigated.
Federal State Institution "Nizhniy Novgorod Scientific Research Institution of Traumatology and Orthopedics of Federal Agency for High-Technological Medical Help", Nizhny Novgorod, Russia. levin@unn.ac.ru
G Y
GY
Levin
M N
MN
Egorihina
D000208:Acute Disease; D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000473:pathology*; D002056:Burns / Q000097:blood*; D005340:Fibrinogen / Q000032:analysis / Q000502:physiology*; D006801:Humans; D010084:Oxidation-Reduction; D010974:Platelet Aggregation / Q000187:drug effects / Q000502:physiology*
D000244:Adenosine Diphosphate; D005340:Fibrinogen