Positive impact of long-term lifestyle change on erythrocyte fatty acid profile after acute coronary syndromes.
BACKGROUND
The outcome of coronary diseases is influenced by lifestyle and diet. Among dietary factors, n-3 polyunsaturated fatty acids reduce mortality from cardiovascular diseases.


OBJECTIVE
To evaluate the impact of dietary and lifestyle advice by calculation of scores and analysis of plasmatic lipids and the fatty acid composition of erythrocyte membrane phospholipids after 1 year of patient education in 66 patients with acute coronary syndromes.


METHODS
The answers given by patients during questioning were transformed into scores (atherosclerosis risk, dietary habits and global scores) at inclusion and after 1 year of follow-up. Classical metabolic risk factors and fatty acid composition of erythrocyte phospholipids were determined at the same time.


RESULTS
After 1 year of education, patients improved their different scores, particularly by changing dietary habits. The positive impact was seen in the blood lipid and erythrocyte fatty acid levels: plasma low-density lipoprotein cholesterol and triglyceride concentrations were lowered and n-3 polyunsaturated fatty acid percentages were improved in phospholipids.


CONCLUSIONS
Global score, lipid variables and the nature of the polyunsaturated fatty acids in erythrocyte phospholipids help us to evaluate patients with high coronary artery disease risk and the benefits of long-term dietary and lifestyle advice.
Laboratoire de biochimie, CHU de Rangueil, 1, avenue Jean-Poulhes, 31059 Toulouse cedex 9, France. casparbauguil.s@chu-toulouse.fr <casparbauguil.s@chu-toulouse.fr>
Sylvie
S
Caspar-Bauguil
Jésus
J
Garcia
Anne
A
Galinier
Brigitte
B
Périquet
Jean
J
Ferrières
Sylvie
S
Allenbach
Nathalie
N
Morin
Pascal
P
Héricotte
Robert
R
Salvayre
Marc
M
Baudet
D054058:Acute Coronary Syndrome / Q000097:blood / Q000209:etiology / Q000628:therapy*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet / Q000009:adverse effects*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D015444:Exercise; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D008297:Male; D008875:Middle Aged; D010353:Patient Education as Topic; D010743:Phospholipids / Q000097:blood*; D040242:Risk Reduction Behavior; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
D015415:Biomarkers; D008078:Cholesterol, LDL; D015525:Fatty Acids, Omega-3; D010743:Phospholipids; D014280:Triglycerides