Haplotypes of the adrenergic system predict the blood pressure response to beta-blockers in women with essential hypertension.
OBJECTIVE
To analyze the association of haplotypes of the adrenergic system with essential hypertension and with the blood pressure response to beta-blockers.


METHODS
In 1112 never-treated essential hypertension patients and 203 normotensive controls, tightly linked SNPs of beta-adrenergic receptors (ADRB1 - Ser49Gly and Arg389Gly; ADRB2 - Cys19Arg, Gly16Arg and Gln27Glu) and the G-protein beta3-subunit (GNB3 - A3882C, G5249A and C825T) were genotyped. Association of haplotypes with essential hypertension and with the blood pressure response to atenolol 50 mg twice daily in a subgroup of essential hypertension patients (n = 340) was evaluated (Haploview 3.2).


RESULTS
No SNPs or haplotypes were associated with essential hypertension. In females only, GNB3 SNPs and haplotypes were associated with the blood pressure response (p < 0.05).


CONCLUSIONS
Our study confirmed the sex-specific association of GNB3 with the blood pressure response to atenolol with no substantial advantage of the analysis of haplotypes over SNPs.
Filigheddu
Fabiana
F
Chair of Emergency, University of Sassari Medical School and Hypertension & Cardiovascular Prevention Center, Viale S Pietro 8, 07100 Sassari, Italy. ffiligheddu@uniss.it
Argiolas
Giuseppe
G
Degortes
Simona
S
Zaninello
Roberta
R
Frau
Francesca
F
Pitzoi
Silvia
S
Bulla
Emanuela
E
Bulla
Patrizia
P
Troffa
Chiara
C
Glorioso
Nicola
N
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D001262:Atenolol / Q000494:pharmacology; D001483:Base Sequence; D001794:Blood Pressure / Q000187:drug effects* / Q000235:genetics*; D016022:Case-Control Studies; D017931:DNA Primers / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D006239:Haplotypes; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics* / Q000503:physiopathology; D008875:Middle Aged; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics*; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics*
C547787:ADRB1 protein, human; D000319:Adrenergic beta-Antagonists; D017931:DNA Primers; C454420:G-protein beta3 subunit; D018342:Receptors, Adrenergic, beta-1; D018343:Receptors, Adrenergic, beta-2; D001262:Atenolol; D020962:Heterotrimeric GTP-Binding Proteins