The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors.
The continuous flow synthesis of butane-2,3-diacetal protected derivatives has been achieved using commercially available flow chemistry microreactors in concert with solid supported reagents and scavengers to provide in-line purification systems. The BDA protected products are all obtained in superior yield to the corresponding batch processes.
Department of Chemistry, Innovative Technnology Centre, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Catherine F
CF
Carter
Ian R
IR
Baxendale
John B J
JB
Pavey
Steven V
SV
Ley
D000080:Acetals / Q000138:chemical synthesis* / Q000737:chemistry; D002073:Butanes / Q000138:chemical synthesis* / Q000737:chemistry; D004867:Equipment Design; D008832:Microchemistry / Q000295:instrumentation* / Q000379:methods
D000080:Acetals; D002073:Butanes; C046888:butane