Galectin fingerprinting in Warthin's tumors: lectin-based approach to trace its origin?
Warthin's tumor of the parotid gland is assumed to originate from the proliferation of epithelial inclusions within parotid lymph nodes. In that case, these cells are supposed to retain characteristics similar to common salivary gland ductal cells. Using immunohistochemical fingerprinting with four members of the family of adhesion/growth-regulatory galectins and comparison to intra- and interlobular ducts, marked similarities were noted for presence of galectins-3, -7 and -8. Notably, profiles of lectin binding, determined by applying human lectins as probes, were also similar when testing biotinylated galectins-3 and -8. Besides defining the galectin histochemical parameters in Warthin's tumors this study adds support to the hypothesis of heterotopia.
Laboratory of Anatomy, Faculty of Medicine and Pharmacy, University of Mons-Hainaut, Mons, Belgium. sven.saussez@umh.ac.be
Sven
S
Saussez
Laurence
L
de Leval
Christine
C
Decaestecker
Nicolas
N
Sirtaine
Stéphanie
S
Cludts
Anaelle
A
Duray
Dominique
D
Chevalier
Sabine
S
André
Hans-Joachim
HJ
Gabius
Myriam
M
Remmelink
Xavier
X
Leroy
D000235:Adenolymphoma / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D037483:Galectin 1 / Q000378:metabolism; D037502:Galectin 3 / Q000378:metabolism; D037161:Galectins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008954:Models, Biological; D010307:Parotid Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D010449:Peptide Mapping; D012189:Retrospective Studies
D037483:Galectin 1; D037502:Galectin 3; D037161:Galectins; C445499:LGALS1 protein, human; C092525:LGALS7 protein, human; C091991:LGALS8 protein, human