Extracellular concentrations of fosfomycin in lung tissue of septic patients.
OBJECTIVE
The present investigation explored the ability of fosfomycin to penetrate lung tissue of septic patients by utilizing the microdialysis technique.


METHODS
After microdialysis probe insertion into healthy and infected lung tissue, a single intravenous dose of 4 g of fosfomycin was administered.


RESULTS
The mean C(max), T(max), AUC(0-4) and AUC(0-infinity) for healthy lung were 131.6 +/- 110.6 mg/L, 1.1 +/- 0.4 h, 242.4 +/- 101.6 mgxh/L and 367.6 +/- 111.9 mgxh/L, respectively. The corresponding values for infected lung were 107.5 +/- 60.2 mg/L, 1.4 +/- 0.5 h, 203.5 +/- 118.4 mgxh/L and 315.1 +/- 151.2 mgxh/L. The half-life of fosfomycin ranged from 2.2 to 2.7 h between compartments. The magnitude of lung tissue penetration, as determined by the ratios of the AUC(0-infinity) for lung to the AUC(0-infinity) for plasma, was 0.63 +/- 0.31 and 0.53 +/- 0.31 for healthy and infected lung, respectively.


CONCLUSIONS
We conclude that fosfomycin achieves antimicrobially effective concentrations in infected lung tissue.
Division of Thoracic and Hyperbaric Surgery, Medical University of Graz, Graz, Austria.
Veronika
V
Matzi
Jörg
J
Lindenmann
Christian
C
Porubsky
Sylvia A
SA
Kugler
Alfred
A
Maier
Peter
P
Dittrich
Freyja M
FM
Smolle-Jüttner
Christian
C
Joukhadar
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D005260:Female; D005578:Fosfomycin / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008168:Lung / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D005578:Fosfomycin