Gukulenins A and B, cytotoxic tetraterpenoids from the marine sponge Phorbas gukulensis.
Gukulenins A (1) and B (2), both having an unprecedented skeleton with a bis-tropolone moiety, were isolated from the Korean marine sponge Phorbas gukulensis. They exhibited significant cytotoxicity against human pharynx, stomach, colon, and renal cancer cell lines in the range 0.05-0.80 microM.
Department of Oceanography, Kunsan National University, Jeonbuk, 673-701, South Korea.
Su Young
SY
Park
Hyukjae
H
Choi
Hoosang
H
Hwang
Heonjoong
H
Kang
Jung-Rae
JR
Rho
D000818:Animals; D004354:Drug Screening Assays, Antitumor; D045325:HCT116 Cells; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011161:Porifera / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D013729:Terpenes; C549725:gukulenin A; C549726:gukulenin B