Production of 4-hydroxyphenyllactic acid by Lactobacillus sp. SK007 fermentation.
The production of 4-hydroxyphenyllactic acid (4-HO-PLA), a novel antifungal compound, was studied in Lactobacillus sp. SK007 growth. When grown in MRS broth, the strain could produce 75 microg/ml HO-4-PLA, which was the highest reported so far. Tyrosine and 4-hydroxyphenylpyruvic acid (HO-4-PPA) supplements during fermentation could both increase the HO-4-PLA production yield, and the effect of HO-4-PPA on HO-4-PLA production was remarkably better than that of tyrosine. Using HO-4-PPA as substrate could effectively produce HO-4-PLA, which reached 1.26 mg/ml.
State Key Laboratory of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, P. R. China. wmmu@jiangnan.edu.cn
Wanmeng
W
Mu
Yu
Y
Yang
Jianghua
J
Jia
Tao
T
Zhang
Bo
B
Jiang
D000935:Antifungal Agents / Q000378:metabolism*; D005285:Fermentation; D005516:Food Microbiology; D007700:Kinetics; D007778:Lactobacillus / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D010666:Phenylpropionates / Q000378:metabolism*; D010667:Phenylpyruvic Acids / Q000378:metabolism / Q000494:pharmacology; D014443:Tyrosine / Q000378:metabolism / Q000494:pharmacology
D000935:Antifungal Agents; D010666:Phenylpropionates; D010667:Phenylpyruvic Acids; C010590:4-hydroxyphenylpyruvic acid; C001418:4-hydroxyphenyllactic acid; D014443:Tyrosine