What would be left behind if subtotal thyroidectomy were preferred instead of total thyroidectomy?
BACKGROUND
The choice between subtotal thyroidectomy (STT) and total thyroidectomy (TT) for multinodular goiter (MNG) remains controversial.


METHODS
Thyroid tissue samples of 34 patients who underwent TT for multinodular disease between October 2005 and June 2007 in Pamukkale University Hospital, Department of General Surgery were evaluated. Thyroid tissues weighing 2 g each from either side were separated from the main specimen to simulate the tissues that would be left behind if a subtotal resection were performed instead of a total resection. Ki-67 staining was performed.


RESULTS
The mean age of subjects was 49.3 +/- 12 years and 25 (73.5%) were females. Papillary microcarcinomas were found in 4 patients, 1 of which was in a residual thyroid specimen (RTS). Micronodule formations were found in 73.5% of specimens simulating residual thyroid. While Ki-67 indexes of residual thyroid tissues were 4.65% in nodules and 1.91% in normal areas (P < .05), they were 5.42% and 2.84%, respectively, for nodular and normal areas in the main specimens (P < .05).


CONCLUSIONS
Remnant thyroid tissues, following STT, have a high percentage of micronodule formation with a remarkable cellular proliferative activity.
Department of General Surgery, Faculty of Medicine, Pamukkale University, Denizili, Turkey. koraytekin@hotmail.com
Koray
K
Tekin
Sevda
S
Yilmaz
Nagihan
N
Yalçin
Sermin
S
Coban
Cağatay
C
Aydin
Burhan
B
Kabay
Ergun
E
Erdem
Serdar
S
Ozbaş
Akin
A
Ozden
D002291:Carcinoma, Papillary / Q000473:pathology / Q000601:surgery; D005260:Female; D006042:Goiter / Q000473:pathology* / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual; D018709:Statistics, Nonparametric; D013964:Thyroid Neoplasms / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy / Q000379:methods*; D016896:Treatment Outcome