Boronic acid catalyzed ene carbocyclization of acetylenic dicarbonyl compounds.
The discovery and development of an efficient ene carbocyclization of 1,3-dicarbonyl compounds bearing pendent terminal alkyne substituents under 3-nitrobenzeneboronic acid catalysis is described. The reaction is efficient, easy to perform and general to a wide range of ketoester substrates.
Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 3TA, UK.
Meiling
M
Li
Ting
T
Yang
Darren J
DJ
Dixon
D000480:Alkynes / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007659:Ketones / Q000737:chemistry
D000480:Alkynes; D001897:Boronic Acids; D007659:Ketones; C017562:3-nitrobenzeneboronic acid