N-acyliminium intermediates in solid-phase synthesis.
N-Acyliminium ions are powerful intermediates in synthetic organic chemistry. Examples of their use are numerous in solution-phase synthesis, but there are unmerited few reports on these highly reactive electrophiles in solid-phase synthesis. The present review covers the literature to date and illustrates the methods used to generate N-acyliminium intermediates on solid support and their further elaboration to a range of pharmacologically interesting peptidomimetics, heterocycles, and other small molecules.
Department of Chemistry, Technical University of Denmark, Kemitorvet, Building 201, DK-2800 Kgs. Lyngby, Denmark.
Sebastian T
ST
Le Quement
Rico
R
Petersen
Morten
M
Meldal
Thomas E
TE
Nielsen
D032701:Biomimetics; D020650:Combinatorial Chemistry Techniques; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*
D007097:Imines; D010455:Peptides