Association of dietary AGEs with circulating AGEs, glycated LDL, IL-1α and MCP-1 levels in type 2 diabetic patients.
OBJECTIVE
The association of dietary advanced glycation endproducts (AGEs) intake with the oxidative and inflammatory status in type 2 diabetic patients was examined.


METHODS
Seventy-four healthy controls, 50 low AGEs intake and 68 high AGEs intake type 2 diabetic patients were requested to complete a 7-day dietary record. Blood levels of several oxidative and inflammatory biomarkers were determined.


RESULTS
Diabetic patients with high AGEs intake had significantly elevated plasma levels of AGEs, HbA1c, low-density lipoprotein (LDL), LDL-cholesterol and glycated LDL than low AGEs intake patients and controls (P < 0.05). These high AGEs intake patients also had significantly increased plasma levels of 8-isoprostane, interleukin (IL)-1α, tumor necrosis factor-α, monocyte chemoattractant protein (MCP)-1 and lower superoxide dismutase (SOD) activity than low AGEs intake patients (P < 0.05). Correlation coefficients of dietary AGEs versus plasma AGEs, HbA1c, 8-isoprostane, IL-1α and MCP-1 were >0.6; but the correlation coefficient of dietary AGEs versus plasma SOD activity was <-0.6.


CONCLUSIONS
Increasing dietary AGEs intake might enrich circulating AGE level and contribute to oxidative and inflammatory progression under diabetic condition. The circulating 8-isoprostane, IL-1α and MCP-1 levels and SOD activity might be appropriate biomarkers used to evaluate dietary AGEs-associated oxidative and inflammatory stress.
Department of Nutritional Science, Chung Shan Medical University, Taichung City, Taiwan.
Pei-chun
PC
Chao
Chien-ning
CN
Huang
Cheng-chin
CC
Hsu
Mei-chin
MC
Yin
Yu-ru
YR
Guo
D000328:Adult; D000368:Aged; D015415:Biomarkers; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D053582:Interleukin-1alpha / Q000097:blood / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D013482:Superoxide Dismutase / Q000097:blood / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood / Q000378:metabolism; D000093844:Glycated Proteins
D015415:Biomarkers; D018932:Chemokine CCL2; D008078:Cholesterol, LDL; D015237:Dinoprost; D017127:Glycation End Products, Advanced; D053582:Interleukin-1alpha; D008077:Lipoproteins, LDL; D013482:Superoxide Dismutase; D014409:Tumor Necrosis Factor-alpha; C111835:CCL2 protein, human; C031797:glycated lipoproteins, LDL; D000093844:Glycated Proteins; C075750:8-epi-prostaglandin F2alpha