Analysis and prediction of nutritional requirements using structural properties of metabolic networks and support vector machines.
Properties of graph representation of genome scale metabolic networks have been extensively studied. However, the relationship between these structural properties and functional properties of the networks are still very unclear. In this paper, we focus on nutritional requirements of organisms as a functional property and study the relationship with structural properties of a graph representation of metabolic networks. In order to examine the relationship, we study to what extent the nutritional requirements can be predicted by using support vector machines from structural properties, which include degree exponent, edge density, clustering coefficient, degree centrality, closeness centrality, betweenness centrality and eigenvector centrality. Furthermore, we study which properties are influential to the nutritional requirements.
Tamura
Takeyuki
T
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan. tamura@kuicr.kyoto-u.ac.jp
Christian
Nils
N
Takemoto
Kazuhiro
K
Ebenhöh
Oliver
O
Akutsu
Tatsuya
T
D000465:Algorithms; D003198:Computer Simulation; D053858:Metabolic Networks and Pathways; D008954:Models, Biological; D015233:Models, Statistical; D009751:Nutritional Requirements; D011506:Proteins / Q000235:genetics / Q000378:metabolism*
D011506:Proteins