Carcinosarcoma of the pleura and lung metastasized from a poorly differentiated squamous cell carcinoma of the esophagus.
Transformation of a poorly differentiated squamous cell carcinoma (SCC) of the esophagus into a âcarcinosarcomaâ of the pleura and lung has never been reported and its histogenetic origin is still debated. A 48-year-old man was admitted due to progressive dysphagia and a weight loss of 5 kilograms within 2 months. Upper gastrointestinal panendoscopic biopsy revealed poorly differentiated SCC of thoracic esophagus, upper third, T4N1M1a, stage IVa. He received concurrent chemoradiotherapy (CCRT). About 9 months later, rapid progression of lung metastases and pleural effusion were found. According to the histopathological and immunohistochemical stain results, carcinosarcoma was diagnosed. Palliative therapy was given and the patient eventually died of the disease 9 months after SCC of the thoracic esophagus was diagnosed and one month after carcinosarcoma of the pleura and lung were confirmed.
Tri-Service General Hospital, Taipei, Taiwan. ndmc.tw.tw@gmail.com
Jing-Lan
JL
Chen
Kuan-Ye
KY
Chen
Chin-Jung
CJ
Lin
Wann-Cherng
WC
Perng
Jia-Hong
JH
Chen
D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002296:Carcinosarcoma / Q000175:diagnosis* / Q000556:secondary*; D004938:Esophageal Neoplasms / Q000473:pathology; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D010997:Pleural Neoplasms / Q000556:secondary