Five-year follow-up in elastase-induced aneurysms in rabbits.
OBJECTIVE
There is no report regarding patency of elastase-induced aneurysms for more than a 2-year period. Our aim was to report aneurysm patency rates up to 5 years in the elastase-induced aneurysm model in rabbits.


METHODS
Twenty-five elastase-induced aneurysms were created in New Zealand white rabbits and followed for up to 5 years. Thirteen (52%) rabbits died during follow-up for reasons unrelated to the aneurysms. DSA was performed at 1 month and at 2 and 5 years in the 12 surviving subjects. Aneurysm patency and dimensions, including neck diameter and aneurysm width and height, were evaluated at each time point in relation to external sizing devices. Differences of aneurysm sizes (neck width and aneurysm width and height) among time points were compared by using the Student t test.


RESULTS
Eleven (92%) of the 12 aneurysms in the subjects that survived for 5 years remained fully patent throughout follow-up. A single narrow-neck aneurysm showed partial thrombosis at the 2- and 5-year time points.


CONCLUSIONS
Experimental elastase-induced aneurysms in rabbits demonstrate high rates of patency up to 5 years following creation. When planning for very long-term studies, investigators should plan for relatively high rates of mortality unrelated to aneurysm pathology.
Neuroradiology Research Laboratory, Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA.
Y
Y
Ding
D
D
Dai
R
R
Kadirvel
D A
DA
Lewis
David F
DF
Kallmes
D000783:Aneurysm / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015901:Angiography, Digital Subtraction; D000818:Animals; D016122:Brachiocephalic Trunk / Q000000981:diagnostic imaging; D004195:Disease Models, Animal; D018450:Disease Progression; D010196:Pancreatic Elastase / Q000009:adverse effects*; D011817:Rabbits; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013997:Time Factors; D014654:Vascular Patency / Q000502:physiology*
D010196:Pancreatic Elastase