Antitumor activity of the immunomodulatory lead Cumaside.
A new immunomodulatory lead Cumaside that is a complex of monosulfated triterpene glycosides from the sea cucumber Cucumaria japonica and cholesterol possesses significantly less cytotoxic activity against sea urchin embryos and Ehrlich carcinoma cells than the corresponding glycosides. Nevertheless Cumaside has an antitumor activity against different forms of experimental mouse Ehrlich carcinoma in vivo both independently and in combination with cytostatics. The highest effect occurs at a treatment once a day for 7 days before the tumor inoculation followed by Cumaside treatment once a day for 7 days. Prophylactic treatment with Cumaside and subsequent therapeutic application of 5-fluorouracil suppressed the tumor growth by 43%.
Pacific Institute of Bioorganic Chemistry, Far East Division of the Russian Academy of Sciences, 690022 Vladivostok, Russia.
D L
DL
Aminin
E L
EL
Chaykina
I G
IG
Agafonova
S A
SA
Avilov
V I
VI
Kalinin
V A
VA
Stonik
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D045744:Cell Line, Tumor; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000627:therapeutic use; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006027:Glycosides / Q000737:chemistry / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D012503:Saponins / Q000627:therapeutic use; D014315:Triterpenes / Q000737:chemistry / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D006027:Glycosides; D007155:Immunologic Factors; D012503:Saponins; D014315:Triterpenes; C539161:cucumarioside A2-2; C551852:cumaside; D002784:Cholesterol; D005472:Fluorouracil