PICS-ure this: prosenescence therapy?
Senescence is increasingly recognized as a critical feature of mammalian cells to suppress tumorigenesis, acting together with cell death programs. Whether senescence, like programmed cell death, can be exploited therapeutically has been unclear. Pandolfi and coworkers now propose that PTEN-loss-induced cellular senescence (PICS) may be triggered in vivo for therapy.
The Netherlands Cancer Institute, Division of Molecular Genetics, 1066 CX Amsterdam, the Netherlands. d.peeper@nki.nl
Daniel S
DS
Peeper