Pure red cell aplasia and primary antiphospholipid syndrome: a unique association.
Pure red cell aplasia (PRCA) is a disease with important relationships to autoimmune mechanisms. Although some autoimmune diseases, such as rheumatoid arthritis and systemic lupus erythematosus, have been associated with PRCA, until this point no studies have described the association between PRCA and primary antiphospholipid syndrome (APS). This is the first case report of PRCA associated with primary APS in a 39-year-old man with acute heart failure secondary to an anaemic condition that was diagnosed as pure red cell aplasia. The patient was later diagnosed with retinal artery and vein thromboses and bilateral deep venous thromboses of the femoral and popliteal veins. The most common causes of PRCA and other thrombophilias were ruled out in this investigation through complementary tests. This association with APS adds a new possibility to the study of PRCA pathophysiology.
Rheumatology Division, Faculdade de Medicina da Universidade de São Paulo, Avenida Dr Arnaldo 455, 3º andar, sala 3190, São Paulo, SP 01246-903, Brazil.
Cezar Augusto Muniz
CA
Caldas
Jozélio Freire
JF
de Carvalho
D000208:Acute Disease; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000097:blood / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D015551:Autoimmunity; D015415:Biomarkers / Q000097:blood; D001803:Blood Transfusion; D005268:Femoral Vein; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D011152:Popliteal Vein; D012010:Red-Cell Aplasia, Pure / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D015356:Retinal Artery Occlusion / Q000209:etiology; D012170:Retinal Vein Occlusion / Q000209:etiology; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000209:etiology
D015415:Biomarkers; D007166:Immunosuppressive Agents