Comparison of clinical outcomes following guided tissue regeneration treatment with a polylactic acid barrier or a collagen membrane.
This prospective, randomized, controlled clinical trial compared the clinical outcomes for a polylactic acid barrier versus a collagen membrane in conjunction with guided tissue regeneration (GTR). Thirty patients with chronic periodontitis and at least one intrabony defect of a minimum 4 mm were enrolled. Following full-mouth scaling, GTR using a collagen membrane or a polylactic acid barrier was performed at one site in each patient. At 1 week before and 6 months after surgery, probing pocket depth (PPD), clinical attachment level (CAL), marginal tissue recession, and bone fill were assessed. A significant reduction in PPD (2.50 +/- 1.35 mm for the polylactic acid barrier and 2.60 +/- 1.08 mm for the collagen membrane) was obtained, in addition to gains in CAL (2.40 +/- 1.17 mm for the polylactic acid barrier and 2.60 +/- 1.26 mm for the collagen membrane) and bone fill (0.33 +/- 1.89 mm for polylactic acid barrier and 2.57 +/- 1.64 mm for collagen membrane), for each group compared to baseline. Significantly, the results from 6 months after surgery showed that there was greater bone fill when the collagen membrane was used compared to the polylactic acid barrier.
Department of Periodontics, Taipei Veterans General Hospital, Taiwan.
Shih-Yun
SY
Wu
Yen-Ting
YT
Chen
Chi-Wei
CW
Chen
Lin-Yang
LY
Chi
Nai-Ying
NY
Hsu
Shan-Ling
SL
Hung
Li-Jane
LJ
Ling
D020341:Absorbable Implants; D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery*; D000704:Analysis of Variance; D001861:Bone Regeneration; D055113:Chronic Periodontitis / Q000601:surgery; D003094:Collagen; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D019344:Lactic Acid; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010512:Periodontal Index; D011091:Polyesters; D011108:Polymers; D011446:Prospective Studies; D018709:Statistics, Nonparametric
D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D003094:Collagen