Neuropsychological performance of South African treatment-naïve adolescents with alcohol dependence.
BACKGROUND
Alcohol dependence (AD) in developmentally vulnerable adolescents is ubiquitous and confers a risk for long-term neurocognitive sequelae, yet comorbid substance use disorders and psychopathology can complicate interpretations. Here, we compare cognitive functioning in adolescents with and without AD, who are free from comorbid disorders.


METHODS
English- and Afrikaans-speaking adolescents (13-15 years) of mixed ancestry and low socio-economic status were recruited from the Cape Town region of South Africa. Adolescents with psychiatric, developmental, or other substance use disorders (SUDs) were excluded. AD (n=26) and control (n=26) groups were matched on age, gender, language, and level of education. Neuropsychological testing in participants' home language followed detailed medical/psychiatric evaluation.


RESULTS
Although our sample included participants who smoked tobacco, lifetime dosage of other drugs was negligible. When tobacco and other drug use as well as demographic variables were controlled, adolescents with AD performed more poorly on measures of Verbal Story Memory, Self-Monitoring, and Psychomotor Speed and Coordination.


CONCLUSIONS
These preliminary results, although relatively subtle, suggest that adolescents with AD may be at increased risk for failure to reach optimal levels of neuromaturation, and may be susceptible to cognitive problems associated with protracted alcohol consumption.
Stellenbosch University, Faculty of Health Sciences, Department of Psychiatry, Tygerberg, 7505 Cape Town, South Africa. hferrett@sun.ac.za
Helen L
HL
Ferrett
Paul D
PD
Carey
Kevin G F
KG
Thomas
Susan F
SF
Tapert
George
G
Fein
D000293:Adolescent; D000437:Alcoholism / Q000469:parasitology*; D003072:Cognition Disorders / Q000139:chemically induced / Q000523:psychology; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008570:Memory, Short-Term; D009483:Neuropsychological Tests; D011340:Problem Solving; D011569:Psychiatric Status Rating Scales; D011597:Psychomotor Performance; D012044:Regression Analysis; D012923:Social Class; D013019:South Africa; D019966:Substance-Related Disorders / Q000523:psychology; D014706:Verbal Learning