Disturbed brain activation during a working memory task in drug-naive adult patients with ADHD.
Neuroimaging studies in attention-deficit/hyperactivity disorder (ADHD) have shown abnormalities in several brain areas including the frontostriatal circuitry and were mostly conducted in children and adolescents. We investigated 30 never-medicated adult ADHD patients (16 males) and 30 matched healthy control individuals. Functional magnetic resonance imaging was acquired during a working memory paradigm (n-back). Group activation maps and group differences of activation were calculated using voxel-based analyses. The generic activation pattern was more extended in the control group. In ADHD patients, significantly decreased activation was found in the right inferior parietal cortex. Disturbed parietal brain function may particularly contribute to inattention and working memory impairment in ADHD patients.
Department of Psychiatry and Psychotherapy, University Medical Centre of the Johannes Gutenberg-University Mainz, Germany.
Martin
M
Bayerl
Thomas F
TF
Dielentheis
Goran
G
Vucurevic
Thomas
T
Gesierich
Friederike
F
Vogel
Christoph
C
Fehr
Peter
P
Stoeter
Michael
M
Huss
Andreas
A
Konrad
D000293:Adolescent; D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D001921:Brain / Q000502:physiology*; D005260:Female; D006801:Humans; D013287:Illicit Drugs / Q000009:adverse effects; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis / Q000503:physiopathology* / Q000523:psychology; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D055815:Young Adult
D013287:Illicit Drugs