Chromatin: the final frontier in splicing regulation?
Pre-mRNA splicing, once thought to be a strictly posttranscriptional event in gene expression, is subject to a multitiered network of regulation. Luco et al. now report in Science that this regulation seems to begin with chromatin modifications, suggesting that the histone code may be a prequel to the splicing code.
Fox-Walsh
Kristi
K
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093-0651, USA.
Fu
Xiang-Dong
XD
D017398:Alternative Splicing; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism*; D006657:Histones / Q000235:genetics / Q000378:metabolism; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000378:metabolism; D008954:Models, Biological; D038941:Polypyrimidine Tract-Binding Protein / Q000378:metabolism; D034622:RNA Interference; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism; D012326:RNA Splicing / Q000235:genetics* / Q000502:physiology*; D051497:Receptor, Fibroblast Growth Factor, Type 2 / Q000235:genetics
D002843:Chromatin; D006657:Histones; D012322:RNA Precursors; D038941:Polypyrimidine Tract-Binding Protein; C496353:FGFR2 protein, human; D051497:Receptor, Fibroblast Growth Factor, Type 2