A comparative study of the serological response to Japanese encephalitis vaccine in HIV-infected and uninfected Thai children.
We report a prospective study of mouse brain derived inactivated Japanese encephalitis (JE) vaccine, given in 3-dose EPI program to human immune deficiency virus (HIV)-exposed Thai infants. 18 HIV-infected receiving antiretroviral therapy with median baseline CD4 of 33.1%, and 92 HIV-uninfected children were studied. All but one HIV-infected child seroconverted after the second dose. The geometric mean titers (GMTs) 3 months after the second and third doses in HIV-infected vs HIV-uninfected children were 247 vs 938 (p=0.022), and 2273 vs 24069 (p=0.009), respectively. Urticaria or angioedema found in 4% and 6% in HIV-infected and -uninfected children, respectively (p=1.0). The vaccine was safe and immunogenic but antibody response in HIV-infected children was not as high as in uninfected children.
Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Road, Bangkok-noi, Bangkok, 10700, Thailand. sikch@mahidol.ac.th
Kulkanya
K
Chokephaibulkit
Nottasorn
N
Plipat
Sutee
S
Yoksan
Wanatpreeya
W
Phongsamart
Keswadee
K
Lappra
Pimpanada
P
Chearskul
Sanay
S
Chearskul
Orasri
O
Wittawatmongkol
Nirun
N
Vanprapar
D000914:Antibodies, Viral / Q000097:blood* / Q000276:immunology; D000917:Antibody Formation; D002675:Child, Preschool; D004672:Encephalitis, Japanese / Q000276:immunology / Q000517:prevention & control*; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D006801:Humans; D007117:Immunization, Secondary; D007223:Infant; D022321:Japanese Encephalitis Vaccines / Q000008:administration & dosage / Q000276:immunology*; D008297:Male; D011446:Prospective Studies; D013785:Thailand
D000914:Antibodies, Viral; D022321:Japanese Encephalitis Vaccines