Comparative analysis of cytokine profiles in autoinflammatory and autoimmune conditions.
BACKGROUND
Many disease states are characterized by a biased cytokine profile and determining the level of certain cytokines becomes an important diagnostic and research tool in clinical medicine. We hypothesized that, despite the highly dynamic nature, the profile of cytokines may be characteristic of disease.


METHODS
The level of systemic cytokines was studied in an autoinflammatory condition, familial Mediterranean fever; in an autoimmune disease, systemic lupus erythematosus (SLE), and in healthy controls.


RESULTS
Multivariate statistics with the use of seven variables clustered the patients and control subjects into the four well separated and distinct groups, corresponding to the SLE, FMF attack, FMF remission, and healthy states.


CONCLUSIONS
The model suggested the existence of specific patterns in cytokine levels reflecting the healthy and specific disease states. These findings warrant further investigations to establish whether this approach may serve as a potential meta-biomarker for other inflammatory disorders.
Manukyan
Gayane
G
Group of Molecular and Cellular Immunology and Laboratory of Molecular Genetics, Institute of Molecular Biology, National Academy of Sciences, Yerevan, Armenia.
Ghazaryan
Karine
K
Ktsoyan
Zhanna
Z
Khachatryan
Zaruhi
Z
Kelly
Denise
D
Tatyan
Marieta
M
Agababova
Marina
M
Aminov
Rustam
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D015551:Autoimmunity / Q000276:immunology*; D015415:Biomarkers; D016022:Case-Control Studies; D002648:Child; D016207:Cytokines / Q000097:blood*; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D015415:Biomarkers; D016207:Cytokines