Pseudoangiomatous squamous cell carcinoma in the oral cavity of a dog.
An 8-year-old, spayed, female Labrador Retriever mixed-breed dog was presented to the Cornell University Hospital for Animals with an invasive oral mass involving the upper left fourth premolar and first molar teeth. Initial biopsy results suggested a poorly differentiated squamous cell carcinoma, whereas further histologic examination of the surgically removed mass revealed a hemangiosarcoma-like mass composed of numerous vascular clefts and variable numbers of keratinizing epithelial cells. Histologic and immunohistochemical characteristics were compatible with pseudoangiomatous squamous cell carcinoma, a well-recognized human variant of acanthomatous squamous cell carcinoma. Because of histomorphologic similarities with canine gingival hemangiosarcoma, diagnosticians should be aware of the present tumor variant as a differential diagnosis for vascular-like growths in the oral cavity of dogs.
Cornell University College of Veterinary Medicine, Department of Biomedical Sciences, S2-118 Schurman Hall, Ithaca, NY 14853, USA. TLC72@cornell.edu
Tim
T
Cushing
Sandra
S
Barnard
Rebekah
R
Fleis
Rachel
R
Peters
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D004285:Dogs; D005260:Female; D009062:Mouth Neoplasms / Q000473:pathology / Q000601:surgery / Q000662:veterinary*