Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P(rs7809799) = 8.81 x 10(-11) and P(rs5771069) = 4.21 x 10(-8), respectively).
Franke
Andre
A
Institute for Clinical Molecular Biology, University Hospital Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany. a.franke@mucosa.de
Balschun
Tobias
T
Sina
Christian
C
Ellinghaus
David
D
Häsler
Robert
R
Mayr
Gabriele
G
Albrecht
Mario
M
Wittig
Michael
M
Buchert
Eva
E
Nikolaus
Susanna
S
Gieger
Christian
C
Wichmann
H Erich
HE
Sventoraityte
Jurgita
J
Kupcinskas
Limas
L
Onnie
Clive M
CM
Gazouli
Maria
M
Anagnou
Nicholas P
NP
Strachan
David
D
McArdle
Wendy L
WL
Mathew
Christopher G
CG
Rutgeerts
Paul
P
Vermeire
Séverine
S
Vatn
Morten H
MH
Krawczak
Michael
M
Rosenstiel
Philip
P
Karlsen
Tom H
TH
Schreiber
Stefan
S
D002892:Chromosomes, Human, Pair 22; D002897:Chromosomes, Human, Pair 7; D003093:Colitis, Ulcerative / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D053722:Receptors, Interleukin-17 / Q000235:genetics*; D012307:Risk Factors
C548677:IL17REL protein, human; D053722:Receptors, Interleukin-17