RECK expression in the rat ventral prostate: response to castration involves a balance between epithelial and stromal expression.
RECK is expressed in the rat ventral prostate. The amount of mRNA increased after castration. In situ hybridization and immunohistochemistry demonstrated a transition from epithelial to stromal expression. This demonstrates that stromal cells upregulate RECK expression to regulate matrix metalloproteinases activity responsible for extracellular matrix (ECM) changes occurring after castration.
Department of Anatomy, Cell Biology, Physiology and Biophysics, Institute of Biology, State University of Campinas, Campinas SP, Brazil.
Helene
H
Peters
Taize Machado
TM
Augusto
Alexandre
A
Bruni-Cardoso
Hernandes F
HF
Carvalho
D000818:Animals; D004847:Epithelial Cells / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D058851:GPI-Linked Proteins / Q000096:biosynthesis / Q000235:genetics; D008297:Male; D020782:Matrix Metalloproteinases / Q000378:metabolism; D009919:Orchiectomy; D011467:Prostate / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D017154:Stromal Cells / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis* / Q000235:genetics
D058851:GPI-Linked Proteins; C529735:Reck protein, rat; D025521:Tumor Suppressor Proteins; D020782:Matrix Metalloproteinases