Supraselective injection of intraarterial melphalan as the primary treatment for late presentation unilateral multifocal stage Vb retinoblastoma.
OBJECTIVE
The purpose of this study was to report a case of a 7-year-old girl with unilateral, multifocal Reese Ellsworth Stage Vb retinoblastoma who was successfully treated using intraarterial chemotherapy infusion as the primary therapy.


METHODS
This is an interventional case report. A 7-year-old girl presented with advanced unilateral retinoblastoma. The patient received intraarterial melphalan infusion therapy as the primary treatment.


RESULTS
Complete tumor resolution was seen at 1 month after intraarterial melphalan infusion.


CONCLUSIONS
This case of advanced retinoblastoma in a 7-year-old girl was successfully treated with intraarterial melphalan infusion alone. Treatment resulted in complete resolution of the tumor 1 month after treatment. In comparison with systemic chemotherapy, intraarterial melphalan infusion therapy may be a less toxic and more effective primary treatment option in the future management of advanced retinoblastoma.
Aziz
Hassan A
HA
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida 33136, USA.
Boutrid
Hinda
H
Murray
Timothy G
TG
Berrocal
Audina
A
Wolfe
Stacey Quintero
SQ
Pina
Yolanda
Y
Dorfman
Mark
M
Moftakhar
Roham
R
Fernandes
Cristina E
CE
Reichbach
Jennifer
J
Aziz-Sultan
Mohammad Ali
MA
D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage*; D002648:Child; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008558:Melphalan / Q000008:administration & dosage*; D009367:Neoplasm Staging; D012074:Remission Induction; D019572:Retinal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D012175:Retinoblastoma / Q000188:drug therapy* / Q000473:pathology; D014792:Visual Acuity
D018906:Antineoplastic Agents, Alkylating; D008558:Melphalan