Effect of uric acid on coronary microvascular endothelial function in women: association with eGFR and ADMA.
OBJECTIVE
The aim of this study was to investigate the role of uric acid (UA) in coronary endothelial function via its effects on renal function, other coronary risk factors and asymmetric dimethylarginine (ADMA) in men and women.


METHODS
The study population consisted of 194 consecutive patients (119 men and 75 women) without coronary artery disease. The relationships between UA and coronary endothelial function, estimated glomerular filtration rate (eGFR), ADMA or other biochemical or anthropometric parameters were investigated.


RESULTS
Monovariate analysis of female participants demonstrated that % change in coronary blood flow (CBF) induced by acetylcholine (ACh) was inversely correlated with UA, ADMA and age (r=-0.32, p<0.01; r=-0.31, p<0.05; r=-0.23, p<0.05, respectively), and positively correlated with eGFR (r=0.27, p<0.05). Stepwise regression analysis showed that UA was the only independent predictor of % change in CBF induced by ACh (F value 4.969, p<0.05). Similar analysis of male participants failed to show significant correlations of these variables except for age in monovariate analysis (r=-0.19, p<0.05). Meanwhile, UA was inversely correlated with eGFR in both men and in women (r=-0.25, p<0.01; r=-0.59, p<0.0001, respectively), and ADMA was positively correlated with UA and inversely correlated with eGFR (r=0.36, p<0.05; r=-0.42, p<0.01, respectively) in women but not in men.


CONCLUSIONS
High concentrations of UA correlate with coronary endothelial microvascular dysfunction in women. Further, serum UA concentration is related to eGFR and ADMA only in women, which may result in impaired endothelial function in resistance coronary arteries in women but not in men.
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, Kagoshima, Japan.
So
S
Kuwahata
Shuichi
S
Hamasaki
Sanemasa
S
Ishida
Tetsuro
T
Kataoka
Akiko
A
Yoshikawa
Koji
K
Orihara
Masakazu
M
Ogawa
Naoya
N
Oketani
Keishi
K
Saihara
Hideki
H
Okui
Takuro
T
Shinsato
Takuro
T
Kubozono
Hitoshi
H
Ichiki
Shoji
S
Fujita
Takuro
T
Takumi
Satoshi
S
Yoshino
Mitsuhiro
M
Nakazaki
Masaaki
M
Miyata
Chuwa
C
Tei
D000368:Aged; D000792:Angiography / Q000379:methods; D001120:Arginine / Q000031:analogs & derivatives* / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D005919:Glomerular Filtration Rate; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D018384:Oxidative Stress; D012307:Risk Factors; D012737:Sex Factors; D014527:Uric Acid / Q000378:metabolism / Q000494:pharmacology*
D014527:Uric Acid; C018524:N,N-dimethylarginine; D001120:Arginine