Two new bufadienolides from the rhizomes of Helleborus thibetanus Franch.
Two new bufadienolides, named tigencaoside A(1) and tigencaoside B(2), were isolated from the rhizomes of Helleborus thibetanus Franch., along with two known bufadienolides, hellebrigenin (3) and 5beta,14beta-dihydroxy-19-oxo-3beta-[(alpha-L-rhamnopyranosyl)oxy]bufa-20,22-dienolide (4). Their structures were elucidated on the basis of extensive spectroscopic analysis. Two new compounds were evaluated for their cytotoxic activities against four strains of cultured tumor cells.
Yang
Jian
J
College of Science, Northwest A&F University, Yangling 712100, PR China. vivian54321@gmail.com
Zhang
Yan-hong
YH
Miao
Fang
F
Zhou
Le
L
Sun
Wei
W
D002018:Bufanolides / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D039322:Helleborus / Q000737:chemistry*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry
D002018:Bufanolides; D004365:Drugs, Chinese Herbal; C553717:tigencaoside A; C553718:tigencaoside B