The utilization of fine needle aspiration biopsy (FNAB) and flow cytometry (FC) in the diagnosis and classification of non-Hodgkin B-cell and T-cell lymphomas.
The subtypes of non-Hodgkin lymphomas may have similar morphology, but have a wide variation in origin, immunophenotype and biological features. Many ancillary investigations are available to help overcome these problems, including fine needle aspiration biopsy (FNAB) and flow cytometry (FC). FNAB coupled with FC can reliably distinguish between reactive and neoplastic lymphoid populations. It can be used in the diagnosis and classification of many lymphomas, obviating the need for surgical biopsy in a significant number of patients.
Division of Anatomical Pathology, Faculty of Health Sciences, Stellenbosch University, NHLS, Tygerberg Academic Hospital, South Africa. haematol@icon.co.za
Gillaume J
GJ
Swart
Colleen A
CA
Wright
D044963:Biopsy, Fine-Needle; D005434:Flow Cytometry; D006801:Humans; D016393:Lymphoma, B-Cell / Q000175:diagnosis*; D016399:Lymphoma, T-Cell / Q000175:diagnosis*