The electroretinogram: a useful tool for evaluating age-related macular disease?
With an ageing population, the number of age-related macular disease (ARMD) cases will inevitably rise. This gives greater impetus for the need to identify the disease earlier and assess treatments to slow disease progression. Differing electroretinogram (ERG) modalities have been reviewed in relation to the objective assessment of retinal function in ARMD and for monitoring the effectiveness of clinical interventions. Conflicting results have been found with regard to the efficacy of ERG findings in the investigation of ARMD in previous years. The newer multifocal ERG paradigm provides spatial topographical information about retinal function in ARMD. It has shown promising results in monitoring effectiveness of clinical interventions and studies are continuing in this area. Better knowledge of retinal function in ARMD may lead to enhanced treatments at each phase of the disease.
Ophthalmic Research Group, School of Life and Health Sciences, Aston University, Birmingham B4 7ET, United Kingdom. berrowej@aston.ac.uk
Emma J
EJ
Berrow
Hannah E
HE
Bartlett
Frank
F
Eperjesi
Jonathan M
JM
Gibson
D018450:Disease Progression; D004596:Electroretinography / Q000379:methods* / Q000592:standards*; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D011159:Population Surveillance / Q000379:methods; D012160:Retina / Q000503:physiopathology; D016896:Treatment Outcome