Successful unrelated donor cord blood transplantation for chronic granulomatous disease.
This report exemplified a success of unrelated donor cord blood transplantation (CBT) in a 4-month-old boy with chronic granulomatous disease (CGD). Following Bu14/Cy200/ATG conditioning, the patient received an HLA 2-locus-mismatched cord blood unit, and the total number of infused nucleated cells was 11.52 x 10(7)/kg. Neutrophil engraftment was achieved on day +13, and a platelet count greater than 20 x 10(9)/L was achieved on day +50. The neutrophil oxidative burst was 100% normal with full donor lymphocyte reconstitution at 8 months post-transplant. This case highlights that unrelated donor CBT for CGD is potentially safe and feasible, even in early infancy, when an appropriately matched related or unrelated donor is unavailable.
Division of Hematology and Oncology, Department of Pediatrics, Chang Gung Children's Hospital, Chang Gung University, Taoyuan, Taiwan.
Tang-Her
TH
Jaing
Wen I
WI
Lee
Po-Jen
PJ
Cheng
Shih-Hsiang
SH
Chen
Jing-Long
JL
Huang
Yung-Kuei
YK
Soong
D036101:Cord Blood Stem Cell Transplantation; D006105:Granulomatous Disease, Chronic / Q000628:therapy*; D006648:Histocompatibility; D006801:Humans; D007223:Infant; D008297:Male; D009504:Neutrophils / Q000166:cytology / Q000502:physiology; D016897:Respiratory Burst / Q000502:physiology; D014019:Tissue Donors; D019172:Transplantation Conditioning / Q000379:methods; D016896:Treatment Outcome