Application of crustacean chitin as a co-diluent in direct compression of tablets.
A "simplex-centroid mixture design" was used to study the direct-compression properties of binary and ternary mixtures of chitin and two cellulosic direct-compression diluents. Native milled and fractioned (125-250 microm) crustacean chitin of lobster origin was blended with microcrystalline cellulose, MCC (Avicel PH 102) and spray-dried lactose-cellulose, SDLC Cellactose (composed of a spray-dried mixture of alpha-lactose monohydrate 75% and cellulose powder 25%). An instrumented single-punch tablet machine was used for tablet compactions. The flowability of the powder mixtures composed of a high percentage of chitin and SDLC was clearly improved. The fractioned pure chitin powder was easily compressed into tablets by using a magnesium stearate level of 0.1% (w/w) but, as the die lubricant level was 0.5% (w/w), the tablet strength collapsed dramatically. The tablets compressed from the binary mixtures of MCC and SDLC exhibited elevated mechanical strengths (>100 N) independent of the die lubricant level applied. In conclusion, fractioned chitin of crustacean origin can be used as an abundant direct-compression co-diluent with the established cellulosic excipients to modify the mechanical strength and, consequently, the disintegration of the tablets. Chitin of crustacean origin, however, is a lubrication-sensitive material, and this should be taken into account in formulating direct-compression tablets of it.
Institute of Pharmacy and Food, University of Havana, Havana, Cuba.
Viviana García
VG
Mir
Jyrki
J
Heinämäki
Osmo
O
Antikainen
Niklas
N
Sandler
Ofelia Bilbao
OB
Revoredo
Antonio Iraizoz
AI
Colarte
Olga Maria
OM
Nieto
Jouko
J
Yliruusi
D002482:Cellulose / Q000737:chemistry; D002686:Chitin / Q000737:chemistry*; D005079:Excipients / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry; D008153:Lubrication; D055585:Physical Phenomena; D011208:Powders; D011312:Pressure; D013229:Stearic Acids; D013607:Tablets
D005079:Excipients; D011208:Powders; D013229:Stearic Acids; D013607:Tablets; D002686:Chitin; C031183:stearic acid; D002482:Cellulose; D007785:Lactose; C109691:microcrystalline cellulose