[Agonist 5HT1A-receptors of serotonin 8-OH-DPAT increase the power of collapse of the aorta and mesenteric artery in rats in the presence of endothelin-1 or vasopressin and cause vessel relaxation precollapsing with noradrenaline].
Agonist 5HT1A serotonin receptors 8-OH-DPAT at 70-80% in rats relax the isolated aorta and mesenteric artery, precollapsed with noradrenaline. An inhibitor of NO-synthase L-NAME two or more times suppresses vazodilatatomyh reaction in response to the effect of 8-OH-DPAT. The addition of 8-OH-DPAT to the aorta in a state of rest or precollapsed with endothelin-1 or vasopressin causes an increase in power reduction. A blocker of alpha1-adrenoceptors prazosin almost completely suppress the aorta collapse reaction to the effect of 8-OH-DPAT in the absence of vasoconstrictives, but does not affect the contraction force in response to 8-OH-DPAT of the aorta in the presence of endothelin-1 or vasopressin and does not shift the curve of the dependence of force collapse on the concentration of 8-OH-DPAT. Our data show the existence in the rat aorta of vasodilator and vasoconstrictive 5HT1A receptors. The vasodilator receptors act according to a NO-dependent mechanism. Vasoconstrictive 5HT1A-receptors are in a latent state (silent receptors) and begin to function after preactivation of endothelin-1 or vasopressin receptors. The ability ofvasoconstrictive 5HT1A-receptors to cause aorta reduction remains after washing endothelin-1 off of the aorta and its relaxation.
L M
LM
Kozhevnikova
P V
PV
Avdonin
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D019332:Endothelin-1 / Q000494:pharmacology*; D008297:Male; D008638:Mesenteric Arteries / Q000502:physiology*; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D044263:Receptors, Serotonin, 5-HT1 / Q000378:metabolism; D058825:Serotonin 5-HT1 Receptor Agonists; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects; D014662:Vasoconstrictor Agents / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology; D014667:Vasopressins / Q000494:pharmacology*
D000317:Adrenergic alpha-Antagonists; D019332:Endothelin-1; D044263:Receptors, Serotonin, 5-HT1; D058825:Serotonin 5-HT1 Receptor Agonists; D017366:Serotonin Receptor Agonists; D014662:Vasoconstrictor Agents; D014667:Vasopressins; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D011224:Prazosin