Novel Burkholderiales 23S rRNA genes identified in ileal biopsy samples from children: preliminary evidence that a subtype is associated with perianal Crohn's disease.
A novel family of Burkholderiales bacteria was identified in ileal biopsy specimens from children presenting with symptoms of inflammatory bowel disease. A molecular subtyping approach based on sequencing of a variable region of the bacteria's 23S rRNA genes identified three variants. Pilot analysis identified one variant to be significantly associated with perianal Crohn's disease.
Sim
W H
WH
Enteric Virus Group, Murdoch Childrens Research Institute, Parkville, Victoria 3052, Australia. winnie.sim@mcri.edu.au
Wagner
J
J
Cameron
D J
DJ
Catto-Smith
A G
AG
Bishop
R F
RF
Kirkwood
C D
CD
D000293:Adolescent; D001706:Biopsy; D019117:Burkholderia / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D003424:Crohn Disease / Q000382:microbiology*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D006801:Humans; D007082:Ileum / Q000382:microbiology*; D008969:Molecular Sequence Data; D010802:Phylogeny; D012338:RNA, Ribosomal, 23S / Q000235:genetics; D017422:Sequence Analysis, DNA
D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012338:RNA, Ribosomal, 23S