Minocycline treatment reduces white matter damage after excitotoxic striatal injury.
We investigated the protective effects of minocycline following white matter damage (WMD) in the rat striatum. Excitotoxic lesions were induced by N-Methyl-d-Aspartate (NMDA) microinjections and caused striatal damage, concomitant with microglial/macrophage activation. The excitotoxic lesion both damaged oligodendrocytes (Tau-1(+) cells) and caused a decrease in tissue reactivity for myelin basic protein (MBP) after post-lesional day 3 (PLD). Treatment with the semi-synthetic tetracycline antibiotic minocycline, however, led to oligodendrocyte preservation and decreased myelin impairment. Taken together, these results suggest that white matter damage (WMD) is an important component of the physiopathology of acute striatal damage and that microglial/macrophage activation contributes to this pathological phenomenon.
Edmond and Lily Safra International Institute of Neuroscience of Natal, Natal/RN, Brazil.
Joanilson S
JS
Guimarães
Marco Aurelio M
MA
Freire
Rafael R
RR
Lima
Cristovam W
CW
Picanço-Diniz
Antonio
A
Pereira
Walace
W
Gomes-Leal
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D000911:Antibodies, Monoclonal / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000276:immunology; D003342:Corpus Striatum / Q000187:drug effects* / Q000473:pathology; D004195:Disease Models, Animal; D008262:Macrophage Activation / Q000187:drug effects / Q000276:immunology; D008297:Male; D017628:Microglia / Q000187:drug effects / Q000276:immunology; D008845:Microinjections; D008911:Minocycline / Q000008:administration & dosage / Q000494:pharmacology*; D004676:Myelin Basic Protein / Q000378:metabolism; D016202:N-Methylaspartate; D009836:Oligodendroglia / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000900:Anti-Bacterial Agents; D000911:Antibodies, Monoclonal; D004676:Myelin Basic Protein; C085348:tau-1 monoclonal antibody; D016202:N-Methylaspartate; D008911:Minocycline