Image-guided sentinel lymph node mapping and nanotechnology-based nodal treatment in lung cancer using invisible near-infrared fluorescent light.
Current methods for sentinel lymph node (SLN) mapping and nodal treatment in lung cancer remain inadequate for routine clinical use. In this study, we discuss the potential for using the combination of invisible near-infrared (NIR) fluorescent light and nanotechnology for these applications. NIR fluorescence imaging has recently received significant attention for in vivo imaging applications because of its low tissue autofluorescence, high photon penetration into living tissue, and high signal-to-background ratio. Our large animal in vivo studies have been able to successfully identify SLNs in lung tissue, and several clinical studies have examined the use of NIR fluorescence imaging systems for SLN mapping in breast and gastric cancer. Promising new nanoparticle technologies, when combined with NIR fluorescence imaging, offer the potential for image-guided treatment of lymph nodes at high risk for tumor recurrence. This review provides a theoretic and empiric framework for developing the next generation of diagnostic and therapeutic agents for lung cancer.
Division of Thoracic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
Onkar
O
Khullar
John V
JV
Frangioni
Mark
M
Grinstaff
Yolonda Lorig
YL
Colson
D000818:Animals; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods*; D016503:Drug Delivery Systems; D004867:Equipment Design; D005453:Fluorescence; D005456:Fluorescent Dyes; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000556:secondary / Q000628:therapy*; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D053758:Nanoparticles / Q000627:therapeutic use; D036103:Nanotechnology / Q000295:instrumentation; D011237:Predictive Value of Tests; D045663:Quantum Dots; D019265:Spectroscopy, Near-Infrared / Q000295:instrumentation; D016896:Treatment Outcome
D005456:Fluorescent Dyes