Reduced uptake of the proliferation-seeking radiotracer technetium-99m-labelled pentavalent dimercaptosuccinic acid in a 47-year-old woman with severe breast epithelial hyperplasia taking ibuprofen: a case report.
BACKGROUND
Recent studies have reported a risk reduction in the progression of benign breast disease to breast carcinoma through COX-2 pathways.


METHODS
We present a case of severe epithelial hyperplasia in a 47-year-old woman with increased breast density submitted to scintimammography by the proliferation-imaging tracer Technetium-99m-labelled pentavalent dimercaptosuccinic acid, before and after an oral ibuprofen treatment for 4 weeks. The radiotracer uptake after ibuprofen intake was significantly reduced, both visually and by semi-quantitative analysis, based on a calculation of lesion-to-background ratios.


CONCLUSIONS
In proliferating breast lesions, scintigraphically displayed reduction in Technetium-99m-labelled pentavalent dimercaptosuccinic acid uptake may indicate inhibition by ibuprofen in the pathway of malignant epithelial cell transformation.
Papantoniou
Vassilios J
VJ
Department of Nuclear Medicine, Alexandra University Hospital, Vasilissis Sofias Avenue, Athens, 11528, Greece. vpapantoniou@gmail.com.
Sotiropoulou
Evangelia K
EK
Valsamaki
Pipitsa N
PN
Tsaroucha
Angeliki G
AG
Sotiropoulou
Maria G
MG
Ptohis
Nikolaos D
ND
Stipsanelli
Aikaterini J
AJ
Dimitrakakis
Konstantinos E
KE
Marinopoulos
Spyridon G
SG
Tsiouris
Spyridon T
ST
Antsaklis
Aris J
AJ