[Nonantimicrobial effects of tetracyclines].
Tetracyclines are a family of antibiotics very common in clinical practice that have been used in not infectious affections. One of their most studied actions is their ability to inhibit matrix metalloproteinases (MMPs), a group of proteinases that have been implicated in pathological processes as oncogenesis and inflammation. Tetracyclines have been shown to play an important role in malignant angiogenesis and cancer invasion, which is related with tumor aggressiveness and metastatic potential.They also show anti-inflammatory activity in neurological, respiratory, bone and heart diseases, and in rheumatologic and dermatologic processes. The aim of this review is to make an updating about the non antimicrobial actions of tetracyclines, specially their therapeutic applications in different diseases.
García-Alvarez
Lara
L
Área de Enfermedades Infecciosas, Hospital San Pedro-Centro de Investigación Biomédica de La Rioja, Logroño, Spain.
Oteo
José Antonio
JA
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents / Q000494:pharmacology; D002318:Cardiovascular Diseases / Q000188:drug therapy; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D009422:Nervous System Diseases / Q000188:drug therapy; D011480:Protease Inhibitors / Q000494:pharmacology; D012140:Respiratory Tract Diseases / Q000188:drug therapy; D012216:Rheumatic Diseases / Q000188:drug therapy; D013754:Tetracyclines / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D013754:Tetracyclines
Efectos no antimicrobianos de las tetraciclinas.