No better time to FRET: shedding light on host pathogen interactions.
Understanding the spatio-temporal subversion of host cell signaling by bacterial virulence factors is key to combating infectious diseases. Following a recent study by Buntru and co-workers published in BMC Biology, we review how fluorescence (Forster) resonance energy transfer (FRET) has been applied to studying host-pathogen interactions and consider the prospects for its future application.
Hayward
Richard D
RD
Institute of Structural and Molecular Biology, University College London and Birkbeck, University of London, Gower Street, London WC1E6BT, UK. richard.hayward@ucl.ac.uk
Goguen
Jon D
JD
Leong
John M
JM
D000818:Animals; D001427:Bacterial Toxins / Q000032:analysis; D019556:COS Cells; D002522:Chlorocebus aethiops; D031541:Fluorescence Resonance Energy Transfer / Q000379:methods*; D054884:Host-Pathogen Interactions; D015398:Signal Transduction; D037521:Virulence Factors / Q000032:analysis; D015011:Yersinia pseudotuberculosis / Q000502:physiology
D001427:Bacterial Toxins; D037521:Virulence Factors