Changing prevalence of Escherichia coli with CTX-M-type extended-spectrum beta-lactamases in outpatient urinary E. coli between 2003 and 2008.
One hundred ninety-three single-patient isolates of Escherichia coli harboring extended-spectrum beta-lactamases (ESBL) were identified among 11 407 E. coli urine isolates recovered from single-patient outpatient urine cultures from 2003 to 2008. The percentage of ESBL-producing E. coli among community-onset E. coli urine isolates increased from 0.21% in 2003 to 2.99% in 2008. One hundred seven of the ESBL producers were positive for the presence of bla(CTX-M) genes. The percentage of CTX-M-producing E. coli rose from 0.07% in 2003 to 1.66% in 2008. The annual percentage of ESBL E. coli producing CTX-Ms changed from 35% in 2003 to 64% in 2008. Genes belonging to 3 bla(CTX-M) groups: bla(CTX-M-1) group, bla(CTX-M-2) group, and bla(CTX-M)(-9) group, were detected. In addition, resistance to commonly used antimicrobial agents for community-acquired urinary tract infections was found common among CTX-M-producing E. coli isolates. Ertapenem and nitrofurantoin showed good in vitro activity against CTX-M producers.
Qi
Chao
C
Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA. cqi451@northwestern.edu
Pilla
Varun
V
Yu
Jessica H
JH
Reed
Kurt
K
D000553:Ambulatory Care; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D017714:Community-Acquired Infections / Q000382:microbiology; D000077727:Ertapenem; D004927:Escherichia coli Infections / Q000382:microbiology*; D029968:Escherichia coli Proteins / Q000096:biosynthesis* / Q000145:classification / Q000235:genetics; D005838:Genotype; D006801:Humans; D009582:Nitrofurantoin / Q000494:pharmacology; D015995:Prevalence; D014552:Urinary Tract Infections / Q000382:microbiology*; D014556:Urine / Q000382:microbiology; D056689:Uropathogenic Escherichia coli / Q000187:drug effects* / Q000201:enzymology* / Q000302:isolation & purification; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000145:classification / Q000235:genetics; D047090:beta-Lactams / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D029968:Escherichia coli Proteins; D047090:beta-Lactams; D009582:Nitrofurantoin; D001618:beta-Lactamases; D000077727:Ertapenem