Parallel processing of olfactory memories in Drosophila.
One of the hallmarks of both memory and the underlying synaptic plasticity is that they each rely on short-lived and longer-lived forms. Short-lived memory is thought to rely on modification to existing proteins, whereas long-term memory requires induction of new gene expression. The most common view is that these two processes rely on signaling mechanisms within the same neurons. We recently demonstrated a dissection of the signaling requirements for short and long-lived memory into distinct sets of neurons. Using an aversive olfactory conditioning task in Drosophila, we found that cAMP signaling in different neuron cell types is sufficient to support short or long-term memory independently.
Blum
Allison
A
Watson School of Biological Sciences, Cold Spring Harbor, NY, USA.
Dubnau
Joshua T
JT
D000818:Animals; D003213:Conditioning, Psychological; D000242:Cyclic AMP / Q000502:physiology; D004331:Drosophila melanogaster / Q000502:physiology*; D008568:Memory / Q000502:physiology*; D008959:Models, Neurological; D024521:Mushroom Bodies / Q000502:physiology; D018034:Olfactory Receptor Neurons / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D012903:Smell / Q000502:physiology*
D000242:Cyclic AMP