Covalently linked DNA nanotubes.
The present study introduces an approach to prepare covalently linked DNA nanotubes. A circular DNA that includes at its opposite poles thiol and amine functionalities acts as the building block for the construction of the DNA nanotubes. The circular DNA is cross-linked with a bis-amide-modified nucleic acid to yield DNA nanowires, and these are subsequently cross-linked by a bis-thiolated nucleic acid to yield the DNA nanotubes. Alternatively, a circular DNA that includes four amine functionalities on its poles is cross-linked in one-step by the bis-thiolated nucleic acid to yield the nanotubes. The resulting nanostructures are stable and nonseparable upon heating.
Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel.
Ofer I
OI
Wilner
Anja
A
Henning
Bella
B
Shlyahovsky
Itamar
I
Willner
D000588:Amines / Q000737:chemistry; D004270:DNA, Circular / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D036103:Nanotechnology / Q000379:methods; D043942:Nanotubes / Q000737:chemistry*; D010316:Particle Size; D013438:Sulfhydryl Compounds / Q000737:chemistry; D013499:Surface Properties
D000588:Amines; D004270:DNA, Circular; D013438:Sulfhydryl Compounds