Design and synthesis of enediyne-based peptide with selective peptide-cleaving activity.
A hybrid peptide-enediyne molecule was synthesised and shown to undergo selective intramolecular peptide chain cleavage by the 1,4-diyl radical, the potential intermediate of the enediyne system.
Indian Institute of Technology, Chemistry, IIT Main Road, Kharagpur, West Bengal 721302, India.
Snigdha
S
Roy
Amit
A
Basak
D000595:Amino Acid Sequence; D053281:Enediynes / Q000737:chemistry*; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D053281:Enediynes; D010455:Peptides