Locked nucleic acids: promising nucleic acid analogs for therapeutic applications.
Locked Nucleic Acid (LNA) is a unique nucleic-acid modification possessing very high binding affinity and excellent specificity toward complementary RNA or DNA oligonucleotides. The remarkable properties exhibited by LNA oligonucleotides have been employed in different nucleic acid-based therapeutic strategies both in vitro and in vivo. Herein, we highlight the applications of LNA nucleotides for controlling gene expression.
Veedu
Rakesh N
RN
Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Campusvej 55, DK-5230 Odense M. rnv@ifk.sdu.dk
Wengel
Jesper
J
D052157:Aptamers, Nucleotide / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D021881:DNA, Catalytic / Q000737:chemistry / Q000378:metabolism; D035683:MicroRNAs / Q000737:chemistry / Q000378:metabolism; D009841:Oligonucleotides / Q000737:chemistry* / Q000627:therapeutic use; D016376:Oligonucleotides, Antisense / Q000737:chemistry; D018075:RNA, Complementary / Q000737:chemistry; D034741:RNA, Small Interfering / Q000737:chemistry / Q000378:metabolism
D052157:Aptamers, Nucleotide; D021881:DNA, Catalytic; D035683:MicroRNAs; D009841:Oligonucleotides; D016376:Oligonucleotides, Antisense; D018075:RNA, Complementary; D034741:RNA, Small Interfering; C477371:locked nucleic acid; D004247:DNA