Endometriosis: new concepts in the pathogenesis.
Endometriosis is a gynaecological disease defined by the histological presence of endometrial glands and stroma outside the uterine cavity. Though there are several theories, research scientists remain unsure as to the definitive cause(s) of endometriosis. Considering the relevant health problems caused by endometriosis, all new information on the pathogenesis of this disease, may have important clinical implications. Goal of this article is to summarize the latest advances in the pathogenesis of endometriosis, with particular emphasis on the embryological theory, that has been recently re-proposed. The possible clinical implications of these findings will be discussed.
Signorile
Pietro G
PG
Fondazione Italiana Endometriosi, Via E. Longoni 81, 00155 Rome, Italy.
Baldi
Alfonso
A
D053687:Adult Stem Cells / Q000473:pathology*; D000818:Animals; D002828:Choristoma; D047108:Embryonic Development; D004715:Endometriosis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D004717:Endometrium / Q000196:embryology* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D038081:Organogenesis; D011247:Pregnancy; D014599:Uterus