Two new bufadienolides from the rhizomes of Helleborus thibetanus Franch.
Two new bufadienolides, named tigencaoside A(1) and tigencaoside B(2), were isolated from the rhizomes of Helleborus thibetanus Franch., along with two known bufadienolides, hellebrigenin (3) and 5beta,14beta-dihydroxy-19-oxo-3beta-[(alpha-L-rhamnopyranosyl)oxy]bufa-20,22-dienolide (4). Their structures were elucidated on the basis of extensive spectroscopic analysis. Two new compounds were evaluated for their cytotoxic activities against four strains of cultured tumor cells.
College of Science, Northwest A&F University, Yangling 712100, PR China. vivian54321@gmail.com
Jian
J
Yang
Yan-hong
YH
Zhang
Fang
F
Miao
Le
L
Zhou
Wei
W
Sun
D002018:Bufanolides / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000737:chemistry; D039322:Helleborus / Q000737:chemistry*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry
D002018:Bufanolides; D004365:Drugs, Chinese Herbal; C553717:tigencaoside A; C553718:tigencaoside B