[The role of genetic predisposition in the development of cardiovascular diseases (myocardial infarction, ischemic stroke, unstable stenocardia) and its interaction with conventional risk factors].
To assess the risk of cardiovascular events, the diagnostic effectiveness of molecular-genetic markers (polymorphisms in APOE, ACE (I/D) and MTHFR (C677T) genes) in combination with conventional risk factors has been studied. The prognostic effectiveness of common algorithms (the Framingham scale) is not sufficient for evaluation of risk factors for cardiovascular diseases. The combination of results of molecular-genetic testing with conventional risk factors allows to increase the predictability of cardiovascular risks.
Nazarenko
G I
GI
Skvortsova
V I
VI
Kleĭmenova
E B
EB
Konstantinova
M V
MV
D000368:Aged; D000789:Angina, Unstable / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D001057:Apolipoproteins E / Q000097:blood / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D004247:DNA / Q000235:genetics*; D005260:Female; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000097:blood / Q000235:genetics; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D009203:Myocardial Infarction / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D007703:Peptidyl-Dipeptidase A / Q000097:blood / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011379:Prognosis; D012307:Risk Factors; D012426:Russia / Q000453:epidemiology; D020521:Stroke / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics
D001057:Apolipoproteins E; C032418:5,11-methenyltetrahydrohomofolate; D004247:DNA; D005492:Folic Acid; D007703:Peptidyl-Dipeptidase A