Biosynthesis of the mitochondrial adenine nucleotide translocase (ATPase) inhibitor bongkrekic acid in Burkholderia gladioli.
Biosynthetic studies with (13)C-labelled acetates and methionine revealed that the infamous, food-related toxin bongkrekic acid from Burkholderia gladioli is a polyketide with acetate-derived beta-branches and a carboxylate terminus derived from the methyl group of an acetate.
Rohm
Barbara
B
Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstr. 11a, D-07745 Jena, Germany.
Scherlach
Kirstin
K
Hertweck
Christian
C
D001427:Bacterial Toxins / Q000737:chemistry* / Q000378:metabolism*; D001865:Bongkrekic Acid / Q000737:chemistry* / Q000378:metabolism*; D042725:Burkholderia gladioli / Q000378:metabolism*; D008928:Mitochondria / Q000201:enzymology; D000226:Mitochondrial ADP, ATP Translocases / Q000037:antagonists & inhibitors*; D015394:Molecular Structure
D001427:Bacterial Toxins; D001865:Bongkrekic Acid; D000226:Mitochondrial ADP, ATP Translocases