Correlation between the interaction of the vinculin tail domain with lipid membranes, its phosphorylation and cell mechanical behaviour.
Cell adhesion and cell-cell contacts are a pre-requisite for proper metabolism, protein synthesis and cell survival. Integrins are the transmembrane receptors that link the extracellular matrix via the FAC (focal adhesion complex) with the cytoskeleton. Vinculin is a pivotal FAC protein that has not only been implicated in regulating FAC formation and transmitting mechanical forces, but also in associating with membranous lipids in biological systems.
Center for Medical Physics and Technology, Biophysics Group, Friedrich-Alexander-University of Erlangen-Nuremberg, Henkestrasse 91, 91052 Erlangen, Germany. wgoldmann@biomed.uni-erlangen.de
Wolfgang H
WH
Goldmann
D002448:Cell Adhesion; D002462:Cell Membrane / Q000378:metabolism*; D003599:Cytoskeleton; D022001:Focal Adhesions; D016023:Integrins / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism*; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D016596:Vinculin / Q000737:chemistry / Q000378:metabolism*
D016023:Integrins; D008563:Membrane Lipids; D016596:Vinculin