[Utilization of targeting specific proteins for ubiquitination and degradation].
Ubiquitin-proteasome pathway (UPP) can degrade specific proteins in eukaryotic cells. Targeting specific proteins for ubiquitination and degradation technique, based the theory of UPP and using certain chimeric E3s or protein-targeting chimeric molecules, can specifically knock down the targeted proteins. It is a promising new method for exploring the functions of genes or proteins and, together with gene-silencing technique, may play an important role in basic and clinical research.
Ma
Yi-hui
YH
Department of Pathology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
Zhang
Qiang
Q
Chen
Jie
J
D000818:Animals; D006801:Humans; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D011485:Protein Binding; D021381:Protein Transport; D011994:Recombinant Proteins / Q000378:metabolism; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism; D054875:Ubiquitination
D011994:Recombinant Proteins; D044767:Ubiquitin-Protein Ligases; D046988:Proteasome Endopeptidase Complex