Terminating histone synthesis to preserve centromere integrity.
Histone protein synthesis is activated as cells enter S phase to allow packaging of the newly replicated DNA into chromatin. In this issue of Developmental Cell, Takayama and coworkers elucidate a mechanism for silencing histone expression at the end of S phase in S. pombe. Failure to shut off histone expression disrupts centromeric chromatin structure.
Marzluff
William F
WF
The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA. william_marzluff@med.unc.edu
D002503:Centromere / Q000235:genetics / Q000378:metabolism*; D005800:Genes, Fungal; D006657:Histones / Q000096:biosynthesis* / Q000235:genetics; D012331:RNA, Fungal / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016196:S Phase / Q000235:genetics / Q000502:physiology; D012568:Schizosaccharomyces / Q000166:cytology / Q000235:genetics / Q000378:metabolism; D029702:Schizosaccharomyces pombe Proteins / Q000096:biosynthesis / Q000235:genetics; D014158:Transcription, Genetic
D006657:Histones; D012331:RNA, Fungal; D012333:RNA, Messenger; D029702:Schizosaccharomyces pombe Proteins