Subchronic administration of rosmarinic acid, a natural prolyl oligopeptidase inhibitor, enhances cognitive performances.
It is well known that inhibition of prolyl oligopeptidase (POP) is involved in memory-related function. In this study, we observed that rosmarinic acid (RA) inhibits POP activity with an IC(50) of 63.7 microM. Subsequently, we investigated the cognitive-enhancing effects of RA employing the Morris water maze paradigm. The results demonstrated that RA is non-competitive POP inhibitor and that acute and subchronic RA treatments showed an inverted U-shaped dose-response curve in the platform crossings. Furthermore, chronic RA treatment significantly increased the platform crossings. These results suggest that RA has a cognitive-enhancing effect which may be mediated by inhibition of POP.
Department of Life and Nanopharmaceutical Science, Kyung Hee University, Hoeki-dong, Dongdaemoon-Ku, Seoul 130-701, Republic of Korea.
Dong Hyun
DH
Park
Se Jin
SJ
Park
Jong Min
JM
Kim
Won Yong
WY
Jung
Jong Hoon
JH
Ryu
D000818:Animals; D002934:Cinnamates / Q000008:administration & dosage*; D003071:Cognition / Q000187:drug effects*; D053630:Depsides / Q000008:administration & dosage*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases / Q000737:chemistry*; D015842:Serine Proteinase Inhibitors / Q000008:administration & dosage*; D000097123:Rosmarinic Acid
D002934:Cinnamates; D053630:Depsides; D000085822:Prolyl Oligopeptidases; D012697:Serine Endopeptidases; D015842:Serine Proteinase Inhibitors; D000097123:Rosmarinic Acid