Expression of muscle segment homeobox genes in the developing myocardium.
Msx1 and Msx2 are essential for the development of many organs. In the heart, they act redundantly in development of the cardiac cushions. Additionally, Msx2 is expressed in the developing conduction system. However, the exact expression of Msx1 has not been established. We show that Msx1 is expressed in the cardiac cushions, but not in the myocardium. In Msx2-null mice, Msx1 is not ectopically expressed in the myocardium. The absence of myocardial defects in the Msx2 knock-out can therefore not be attributed to a redundant action of Msx1 in the myocardium.
Heart Failure Research Center, Academic Medical Center of Amsterdam, Amsterdam, The Netherlands.
Cornelis J J
CJ
Boogerd
Antoon F M
AF
Moorman
Phil
P
Barnett
D000818:Animals; D019521:Body Patterning / Q000235:genetics; D054089:Endocardial Cushions / Q000196:embryology / Q000254:growth & development; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D005801:Genes, Homeobox / Q000235:genetics*; D006321:Heart / Q000196:embryology* / Q000254:growth & development; D006329:Heart Conduction System / Q000196:embryology / Q000254:growth & development; D018398:Homeodomain Proteins / Q000096:biosynthesis / Q000235:genetics*; D051957:MSX1 Transcription Factor / Q000096:biosynthesis / Q000172:deficiency / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D038081:Organogenesis / Q000235:genetics
D018398:Homeodomain Proteins; D051957:MSX1 Transcription Factor; C084119:MSX2 protein; C484084:Msx1 protein, mouse