CYLD tidies up dishevelled signaling.
An increasing number of cellular signaling pathways utilize protein ubiquitination for activation of signaling cascades. In this issue of Molecular Cell, Maurice and colleagues demonstrate that nondegradative Lys63-linked polyubiquitin chains modulate Dishevelled (Dvl) activity upstream in the Wnt/beta-catenin signaling pathway.
Komander
David
D
Medical Research Council Laboratory of Molecular Biology, Protein and Nucleic Acid Chemistry Division, Hills Road, Cambridge CB2 0QH, UK. dk@mrc-lmb.cam.ac.uk
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D003528:Carcinoma, Adenoid Cystic / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000074749:Deubiquitinating Enzyme CYLD; D000072261:Dishevelled Proteins; D006801:Humans; D008239:Lysine; D009154:Mutation; D010750:Phosphoproteins / Q000235:genetics / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D015398:Signal Transduction; D012878:Skin Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D015533:Transcriptional Activation; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*; D054875:Ubiquitination; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism*; D060508:Wnt3 Protein; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism*
D048868:Adaptor Proteins, Signal Transducing; C495270:CTNNB1 protein, human; D000072261:Dishevelled Proteins; D010750:Phosphoproteins; D025521:Tumor Suppressor Proteins; D051153:Wnt Proteins; D060508:Wnt3 Protein; D051176:beta Catenin; C409984:CYLD protein, human; D000074749:Deubiquitinating Enzyme CYLD; D008239:Lysine