Antibiotic prescription patterns in hospitalized patients with nursing home-acquired pneumonia.
BACKGROUND
Considerable research has increased our understanding of antibiotic prescribing practices in hospital settings when it comes to nosocomial pneumonia. Much less is known about the antibiotic prescribing patterns for hospitalized non-critically ill patients with nursing home-acquired pneumonia (NHAP).


OBJECTIVE
As part of a multisite quality improvement project, we sought to examine patterns of antibiotic prescription among healthcare providers as a function of underlying comorbid, functional, and clinical factors.


METHODS
Three tertiary care centers.


METHODS
Chart reviews of 397 individual admissions were performed on patients admitted from nursing homes with the diagnosis of pneumonia between January 2005 and September 2007.


RESULTS
Compliance with national guidelines for the treatment of NHAP was poor. Overall, the 3 most commonly used compounds for inpatient treatment were fluoroquinolones (51.4%), ceftriaxone (45.0%), and azithromycin (42.1%). Monotherapy was prescribed in 57.1%. Fluoroquinolones represented 79.5% of these cases. Patients with higher acuity of illness were more likely to receive a combination of vancomycin plus piperacillin/tazobactam (P < 0.001). Median duration of treatment was 8.0 (range, 3-21) days. Stratified analyses showed that combination therapy was used more often on University-affiliated services than on private service (54% vs. 35%; P < 0.001).


CONCLUSIONS
There was poor adherence with antibiotic guidelines for the treatment of NHAP. In the absence of outcome data on guidelines compliance, antibiotic use was influenced by patients' age, severity of illness, and providers' academic affiliation. Future research should focus on outcome measures and physicians factors that influence nonadherence.
The Veterans Affairs Western New York Healthcare System, Buffalo, New York 14215-1199, USA. solh@buffalo.edu
Ali A
AA
El-Solh
Misha
M
Peter
Ziad
Z
Alfarah
Morohunfolu E
ME
Akinnusi
Abbas
A
Alabbas
Lilibeth A
LA
Pineda
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002908:Chronic Disease; D003428:Cross Infection / Q000188:drug therapy*; D005260:Female; D019983:Guideline Adherence; D019538:Health Care Surveys; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009735:Nursing Homes; D011014:Pneumonia / Q000188:drug therapy*; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data*; D011785:Quality Assurance, Health Care / Q000379:methods; D012189:Retrospective Studies; D012720:Severity of Illness Index
D000900:Anti-Bacterial Agents