Relationship between prepulse inhibition of acoustic startle response and schizotypy in healthy Japanese subjects.
Prepulse inhibition (PPI) of the acoustic startle reflex (ASR) is the most common psychophysiological index of sensorimotor gating. Several studies have investigated the relationship of PPI of ASR to schizotypy in Caucasians. However, little has been reported on this relationship in Asians. We investigated a possible relationship between PPI of ASR and schizotypy in 79 healthy Japanese subjects. Schizotypy was assessed by the Schizotypal personality Questionnaire (SPQ). PPI was evaluated at signal-to-noise ratios (SnRs: difference between background noise intensity and prepulse intensity) of +12, +16, and +20 dB. The total SPQ score, cognitive/perceptual score, and interpersonal score correlated negatively with PPI at SnR of +16 and +20 dB. We conclude that PPI is associated with the trait of schizotypy in healthy Asian subjects.
Department of Psychiatry, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. hidetaka@psy.med.osaka-u.ac.jp
Hidetoshi
H
Takahashi
Masao
M
Iwase
Leonides
L
Canuet
Yuka
Y
Yasuda
Kazutaka
K
Ohi
Motoyuki
M
Fukumoto
Naomi
N
Iike
Takayuki
T
Nakahachi
Koji
K
Ikezawa
Michiyo
M
Azechi
Ryu
R
Kurimoto
Ryouhei
R
Ishii
Tetsuhiko
T
Yoshida
Hiroaki
H
Kazui
Ryota
R
Hashimoto
Masatoshi
M
Takeda
D000161:Acoustic Stimulation; D000328:Adult; D001767:Blinking / Q000502:physiology; D004576:Electromyography; D005260:Female; D006801:Humans; D007564:Japan; D008297:Male; D010556:Personality Tests; D013216:Reflex, Startle / Q000502:physiology*; D012569:Schizotypal Personality Disorder / Q000503:physiopathology* / Q000523:psychology*; D055139:Sensory Gating; D012907:Smoking / Q000523:psychology; D011795:Surveys and Questionnaires