Cytokines genes polymorphisms and risk of multiple sclerosis.
Association studies of proinflammatory and anti-inflammatory cytokines single nucleotide polymorphisms with multiple sclerosis (MS) in population with different ethnic background have shown inconsistent results. To study the possible role of tumor necrosis factor-alpha G-308A, interleukin-6 G-174C, interleukin-10 C-592A, C-819T, G-1082A, transforming growth factor (TGF)-beta (codons 10 and 25), and interferon-gamma T+874A polymorphisms in susceptibility to MS in Iranian population, DNA samples from 98 patients and 97 healthy controls were genotyped using polymerase chain reaction-sequence-specific primers. Analysis of the genotypes revealed a significant lower frequencies of tumor necrosis factor-alpha GA and TGF beta C/C G/G genotypes and higher frequency of TGF beta T/C G/C genotype in patients (P < 0.05). Our data suggest that these polymorphisms play a role in susceptibility to MS, which is possibly mediated by dysregulated production of these cytokines.
Izad
Maryam
M
Immunology Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. izadm@tums.ac.ir
Vodjgani
Mohammed
M
Niknam
Mohammed Hossein
MH
Amirzargar
Aliakbar
A
Shahbeigi
Saeed
S
Heidari
Amir Behzad
AB
Keramatipour
Mohammad
M
D000328:Adult; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
D016207:Cytokines