A new long-chain alkene and antituberculosis constituents from the leaves of Pourthiaea lucida.
A new long-chain alkene, dotriacont-1-ene (1), was isolated from the leaves of Pourthiaea lucida, together with twelve known compounds. The structure of this new compound was determined by NMR and mass-spectrometric analyses. Among the isolated compounds, alpha-tocospiro A (2), alpha-tocopheryl quinone (4), and (E)-phytol (5) exhibited antituberculosis activities (MICs <or=30 microg/ml) against Mycobacterium tuberculosis H(37)Rv in vitro.
Chen
Jih-Jung
JJ
Graduate Institute of Pharmaceutical Technology, Tajen University, Pingtung 907, Taiwan. jjchen@mail.tajen.edu.tw
Lin
Wen-Jiou
WJ
Shieh
Po-Chuen
PC
Chen
Ih-Sheng
IS
Peng
Chien-Fang
CF
Sung
Ping-Jyun
PJ
D000475:Alkenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D018515:Plant Leaves / Q000737:chemistry; D027824:Rosaceae / Q000737:chemistry*
D000475:Alkenes; D000995:Antitubercular Agents; C550154:dotriacont-1-ene