Regulation of angiogenesis by macrophages.
Abnormal angiogenesis is a cardinal feature in the pathophysiology of several diseases of the retina including retinopathy of prematurity, diabetic retinopathy and choroidal neovascularization associated with age-related macular degeneration. Recent evidence has implicated macrophages as components of the innate immune system that play a key role in regulating angiogenesis in the retina and choroid. This review will focus on the role of macrophages in regulating ocular angiogenesis.
Barnes Retina Institute, Washington University School of Medicine, St. Louis, MO 63110, USA. apte@vision.wustl.edu
Rajendra S
RS
Apte
D000818:Animals; D016764:Cell Polarity; D006801:Humans; D008264:Macrophages / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000473:pathology*