EGFR (trans)activation mediates IL-8 and distinct human antimicrobial peptide and protein production following skin injury.
Antimicrobial peptides and proteins (AMPs) are tools of the innate immune system employed at injury sites to protect the host from invading microbes and to promote wound repair. In this issue, Roupé et al. characterize epidermal innate immune responses induced by skin injury and the involvement of EGFR for distinct AMPs and IL-8 induction.
Büchau
Amanda S
AS
Department of Immunology and Microbial Science, The Scripps Research Institute, La Jolla, California 92037, USA. abuchau@scripps.edu
D023181:Antimicrobial Cationic Peptides / Q000378:metabolism*; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D012867:Skin / Q000276:immunology* / Q000293:injuries* / Q000378:metabolism; D014945:Wound Healing / Q000276:immunology
D023181:Antimicrobial Cationic Peptides; D016209:Interleukin-8; D066246:ErbB Receptors