Urine suPAR levels compared with plasma suPAR levels as predictors of post-consultation mortality risk among individuals assumed to be TB-negative: a prospective cohort study.
Plasma levels of the inflammatory biomarker soluble urokinase plasminogen activator (suPAR) have been shown to carry prognostic information in various infectious and inflammatory diseases. The present study aimed to compare the prognostic value of urine suPAR (U-suPAR) to that of plasma suPAR (P-suPAR), thereby exploring the possibility of replacing the blood sample with an easy obtainable urine sample. We enrolled 1,007 adults, older than 15 years of age, with a negative TB diagnosis between April 2004 and December 2006. Levels of U-suPAR and P-suPAR were available in 863 individuals. U-suPAR was measured using a commercial ELISA (suPARnostic®). We found that U-suPAR carried significant prognostic information on mortality for HIV-infected subjects with an area under the ROC curve of 0.75. For HIV-negative individuals, little or no prognostic effect was observed. However, in both HIV positives and negatives, the predictive effect of U-suPAR was found to be inferior to that of P-suPAR.
Rabna
Paulo
P
Bandim Health Project, Indepth Network, Apartado 861, Bissau Codex, Guinea-Bissau. p.rabna@bandim.org
Andersen
Andreas
A
Wejse
Christian
C
Oliveira
Ines
I
Francisco Gomes
Victor
V
Bonde Haaland
Maya
M
Aaby
Peter
P
Eugen-Olsen
Jesper
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood / Q000652:urine; D015331:Cohort Studies; D003141:Communicable Diseases / Q000097:blood / Q000175:diagnosis / Q000401:mortality* / Q000652:urine; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000175:diagnosis / Q000401:mortality* / Q000652:urine; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D011933:Reagent Kits, Diagnostic; D012306:Risk; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D016019:Survival Analysis; D014376:Tuberculosis / Q000175:diagnosis; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood* / Q000652:urine*; D055815:Young Adult
D015415:Biomarkers; D011933:Reagent Kits, Diagnostic; D014568:Urokinase-Type Plasminogen Activator