Alterations of serum and placental endoglin in pre-eclampsia.
Serum levels of endoglin were measured in pre-eclamptic women in their third trimester and in women in their second trimester who later developed pre-eclampsia. Placental levels of endoglin at birth were also determined in pre-eclamptic women and healthy controls. Serum endoglin was significantly higher in pre-eclamptic women in the third trimester than in controls (median 35.15 versus 10.35 ng/ml, respectively) and in women with severe compared with mild pre-eclampsia (median 51.68 versus 20.99 ng/ml, respectively). Placental endoglin was also significantly higher in pre-eclamptic women than controls (median 26.24 versus 9.21 ng/mg, respectively) and in women with severe compared with mild pre-eclampsia (median 28.77 versus 13.38 ng/mg, respectively). Pregnant women in the second trimester who eventually developed pre-eclampsia had significantly higher serum endoglin than age- and gestational age-matched controls (median 5.90 versus 5.20 ng/ml, respectively). These findings suggest that endoglin plays an important role in the pathogenesis of pre-eclampsia.
Fang
M
M
Department of Obstetrics, Shaoxing Women and Children's Hospital, Shaoxing, Zhejiang Province, China.
He
Y
Y
Li
H
H
Wu
M
M
Shi
X
X
Du
H
H
D000328:Adult; D015703:Antigens, CD / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D000071063:Endoglin; D005260:Female; D005865:Gestational Age; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000097:blood* / Q000175:diagnosis; D011237:Predictive Value of Tests; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D011956:Receptors, Cell Surface / Q000097:blood*; D055815:Young Adult
D015703:Antigens, CD; D015415:Biomarkers; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface