Finding the middle ground: how kinetochores power chromosome congression.
Genomic stability requires error-free chromosome segregation during mitosis. Chromosome congression to the spindle equator precedes chromosome segregation in anaphase and is a hallmark of metazoan mitosis. Here we review the current knowledge and concepts on the processes that underlie chromosome congression, including initial attachment to spindle microtubules, biorientation, and movements, from the perspective of the kinetochore.
Kops
Geert J P L
GJ
Department of Physiological Chemistry and Cancer Genomics Centre, University Medical Center Utrecht, Stratenum 3.217, Universiteitsweg 100, 3584 CG, Utrecht, The Netherlands. g.j.p.l.kops@umcutrecht.nl
Saurin
Adrian T
AT
Meraldi
Patrick
P
D020090:Chromosome Segregation; D002875:Chromosomes / Q000502:physiology*; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D008677:Metaphase; D008870:Microtubules / Q000378:metabolism; D008938:Mitosis; D008941:Spindle Apparatus / Q000502:physiology