Advantages of peptide nucleic acids as diagnostic platforms for detection of nucleic acids in resource-limited settings.
Peptide nucleic acids are a class of nondegradable oligonucleotide mimics that can be used as probes for nucleic acid sequences and could convey the necessary stability to be a diagnostic tool for use in a resource-limited setting. In this review, there is a brief introduction to the field of peptide nucleic acids and their potential benefits as probes for DNA and RNA sequences, followed by highlights of ways by which peptide nucleic acids could benefit a number of established diagnostic tools for human immunodeficiency virus detection.
Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.
Ning
N
Zhang
Daniel H
DH
Appella
D003141:Communicable Diseases / Q000175:diagnosis*; D004247:DNA / Q000235:genetics / Q000302:isolation & purification*; D003906:Developing Countries; D006801:Humans; D008828:Microbiological Techniques / Q000379:methods*; D015336:Molecular Probe Techniques; D020135:Peptide Nucleic Acids; D012313:RNA / Q000235:genetics / Q000302:isolation & purification*
D020135:Peptide Nucleic Acids; D012313:RNA; D004247:DNA
Diagnostic; HIV; NAT; PNA