Sesquiterpenoid aminoquinones from the marine sponge Dysidea sp.
Four new sesquiterpenoid arenarone derivatives, 18-aminoarenarone (1), 19-aminoarenarone (2), 18-methylaminoarenarone (3), and 19-methylaminoarenarone (4), and the new dimeric popolohuanone F (5), a derivative of 19-aminoarenarone (2) and arenarol (6), have been isolated from the Australian marine sponge Dysidea sp. together with the known compounds arenarol (6) and popolohuanone A (7). The structures of the new compounds 1-5 were established from extensive NMR spectroscopic data. Popolohuanones A (7) and F (5) and arenarol (6) showed DPPH radical scavenging activity with IC(50) values of 35, 35, and 19 microM, respectively.
Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022 Vladivostok, Russian Federation. utkinan@mail.ru
Natalia K
NK
Utkina
Vladimir A
VA
Denisenko
Vladimir B
VB
Krasokhin
D000818:Animals; D001315:Australia; D001713:Biphenyl Compounds / Q000494:pharmacology; D047088:Dysidea / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010851:Picrates / Q000494:pharmacology; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D011809:Quinones; D012717:Sesquiterpenes; C004931:1,1-diphenyl-2-picrylhydrazyl