Isolation and phytotoxicity of terpenes from Tectona grandis.
A study was carried out on the allelopathic potential of four forest species, Tectona grandis, Aleurites fordii, Gliricidia sepium, and Maytenus buxifolia. The most active species, T. grandis, was selected to perform a phytochemical study. A new compound, abeograndinoic acid, was isolated, and elucidation of its structure showed that this compound has an unusual carbon skeleton. A further 21 known terpenoids-including 4 sesquiterpenoids, 8 diterpenes and 9 triterpenes-also were isolated. A biosynthetic scheme for the presence of the new compound is proposed. Bioactivity profiles that used etiolated wheat coleoptiles and phytotoxicity bioassays on the isolated compounds were conducted. The compounds that presented the highest phytotoxic activity are the diterpenes 9 (2-oxokovalenic acid) and 12 (19-hydroxyferruginol).
Departamento de Química Orgánica, Facultad de Ciencias, Universidad de Cádiz, Puerto Real, Cádiz, Spain. famacias@uca.es
Francisco A
FA
Macías
Rodney
R
Lacret
Rosa M
RM
Varela
Clara
C
Nogueiras
Jose M G
JM
Molinillo
D000490:Allium / Q000187:drug effects; D018548:Cotyledon / Q000187:drug effects*; D004224:Diterpenes / Q000302:isolation & purification* / Q000633:toxicity; D019686:Lamiaceae / Q000737:chemistry* / Q000633:toxicity; D029686:Lepidium / Q000187:drug effects; D018545:Lactuca / Q000187:drug effects; D018551:Solanum lycopersicum / Q000187:drug effects; D013729:Terpenes / Q000302:isolation & purification* / Q000633:toxicity; D014197:Trees / Q000737:chemistry* / Q000633:toxicity; D014908:Triticum / Q000187:drug effects*
D004224:Diterpenes; D013729:Terpenes