Genetics of lipid disorders.
OBJECTIVE
In this review, we will highlight recent advances in identifying genes and gene regions responsible for the variation in serum lipid levels. We will also consider the next directions for research based on these advances.


RESULTS
Large-scale genome-wide association studies have successfully screened common variants across the genome for association with serum lipids and have generated novel hypotheses about the causes of serum lipid variation.


CONCLUSIONS
Deep sequencing of genome-wide association signals promises to expand the catalogue of variants responsible for serum lipid variation and, with a full catalogue of variants, we may develop a panel of polymorphisms with clinical utility. In parallel, functional exploration of the genome-wide association signals should expand our knowledge of lipoprotein metabolism and generate targets for pharmacologic intervention.
Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
James
J
Pirruccello
Sekar
S
Kathiresan
D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D006801:Humans; D052439:Lipid Metabolism Disorders / Q000235:genetics*; D008055:Lipids / Q000097:blood* / Q000235:genetics; D010597:Pharmacogenetics; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA
D008055:Lipids