Meta-analysis of evaluating diagnostic accuracy of adenoclone (ELISA) for adenoviral infection among Japanese people.
This study evaluated the diagnostic accuracy of Adenoclone, a rapid diagnostic test kit for adenovirus, among Japanese people of published data. Studies were collected by various literature search engines: PubMed (Medline), ICHUSHI, and GeNii(CiNii, Webcat Plus, KAKEN, NII-DRB, JAORO). Relatively high quality studies, scored via QUADAS, were selected. Data on true positive, false positive, true negative, and false negative results were extracted. Meta-DiSc (version 1.4) was employed to calculate the pooled estimates of diagnostic indices. The 15 studies provided a pooled sensitivity of 50.2% (CI: 47.1-53.3), and a pooled specificity of 97.4% (CI: 96.2-98.3) using conjunctiva swabs. The 2 studies about throat swabs provided a pooled sensitivity of 73.5% (CI: 62.7-82.6), and a pooled sensitivity of 100.0% (CI: 96.6-100.0). The 4 studies tested stool samples, providing a pooled sensitivity of 85.1% (CI: 77.2-91.1), and a pooled specificity of 98.7% (CI: 96.9-99.6), a better outcome than using other specimens (p of the relative diagnostic odds ratio = 0.0017). As the low pooled sensitivity indicates, Adenoclone-negative may not rule out Adenoviral infection sufficiently especially when using conjunctive or throat swabs. However, Adenoclone testing stool samples may yield a stronger diagnostic accuracy than using other specimens.
Department of Medicine, Mizawa Hospital, Hamamatsu 430-0807, Japan. egoto1@nifty.com
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Goto
D000256:Adenoviridae; D000257:Adenoviridae Infections / Q000175:diagnosis*; D044466:Asian People; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D005243:Feces / Q000821:virology; D006801:Humans; D011933:Reagent Kits, Diagnostic; D012680:Sensitivity and Specificity
D011933:Reagent Kits, Diagnostic