A new cytotoxic tambjamine alkaloid from the Azorean nudibranch Tambja ceutae.
The chemical investigation of Azorean nudibranch mollusk Tambja ceutae led us to isolate a new member of the tambjamine family, tambjamine K (1). The bryozoan Bugula dentata, prey of the nudibranch, was also analyzed and found to contain compound 1 in very small amounts together with known blue pigment 2 and tambjamines A (3) and B (4). The structure of tambjamine 1 was elucidated by the interpretation of the spectroscopic data as well as by the comparison with related compounds. Compounds 1 and 2 possess antiproliferative activity, in particular, tambjamine K (1) displayed high cytotoxicity against both tumor and non-tumor mammalian cells.
Istituto di Chimica Biomolecolare, CNR, Via Campi Flegrei 34, I 80078 Pozzuoli (Na), Italy. margherita.gavagnin@icb.cnr.it
Marianna
M
Carbone
Carlo
C
Irace
Francesca
F
Costagliola
Francesco
F
Castelluccio
Guido
G
Villani
Gonçalo
G
Calado
Vinicius
V
Padula
Guido
G
Cimino
J
J
Lucas Cervera
Rita
R
Santamaria
Margherita
M
Gavagnin
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008974:Mollusca / Q000187:drug effects*; D011758:Pyrroles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000970:Antineoplastic Agents; D011758:Pyrroles; C551403:tambjamine K