[Opioid induced cough: Do we know its pathophysiology and can it be eliminated?].
The (intravenous) administration of opioids is frequently associated with the induction of cough. This phenomenon is usually neither harmful for the patient nor bothersome. However, in some situations a severe cough may interfere with imaging, diagnostic or therapeutic procedures and thus, anesthesiologists may want to know effective preventive measures. The existing literature is extremely diverse and the results of clinical trials are sometimes conflicting. Based on experimental investigations in accordance with clinical findings this systematic review of the existing evidence helps to guide the management strategy if opioid induced cough should be avoided. Promising strategies - among others - in order to achieve this aim consist for instance of decreasing the injection speed in conjunction with pre-administration of lidocaine or clonidine.
Schäfer
Michael
M
Klinik für Anästhesiologie mit Schwerpunkt operative Intensivmedizin der Charité - Universitätsmedizin Berlin Campus Virchow Klinikum und Campus Charité Mitte.
Keilig
Susanne
S
Brack
Alexander
A
Kranke
Peter
P
D000316:Adrenergic alpha-Agonists / Q000627:therapeutic use; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000627:therapeutic use; D003000:Clonidine / Q000627:therapeutic use; D003371:Cough / Q000139:chemically induced* / Q000503:physiopathology* / Q000517:prevention & control; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007275:Injections, Intravenous; D008012:Lidocaine / Q000627:therapeutic use; D012018:Reflex / Q000187:drug effects; D012307:Risk Factors
D000316:Adrenergic alpha-Agonists; D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D008012:Lidocaine; D003000:Clonidine; D005283:Fentanyl
Leser fragen - Experten antworten - Hustenreiz nach intravenöser Applikation von Opioiden.