Onset time course of solution induced corneal staining.
OBJECTIVE
To evaluate the early phase time course of solution induced corneal staining.


METHODS
A double masked, single centred, prospective clinical trial was conducted. Twenty-five participants, either experienced or new contact lens wearers, participated in the study. Corneal staining response to short term use of ReNu MultiPlus Multipurpose Solution and PureVision silicon hydrogel contact lens with fluorescein was observed using standard techniques after 15, 30, 45, 60 and 120 min of lens wear and graded according to the IER scale. Measurements were carried out on separate days for each time point, in random order.


RESULTS
Mean extent of staining was greater in test than in control eyes at all time points except baseline. In test eyes, the degree of staining increased successively at each time point after insertion, up to, but not beyond, 60 min. For those participants presenting with staining, maximum severity and frequency were both observed at 60 min and were significantly greater (p < 0.05) than at 15, 30, and 45 min.


CONCLUSIONS
Solution induced corneal staining gradually increased after lens insertion to a maximum at 1h. This level was maintained until at least 2h post-insertion.
The Institute for Eye Research, Sydney NSW, Australia. K.Bandamwar@brienholdenvision.org.au
Kalika L
KL
Bandamwar
Qian
Q
Garrett
David
D
Cheung
Jessie
J
Huang
Ling
L
Lee
Carina
C
Ng
Eric B
EB
Papas
D000293:Adolescent; D000328:Adult; D001645:Biguanides / Q000009:adverse effects*; D018639:Contact Lens Solutions / Q000009:adverse effects*; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects* / Q000473:pathology; D018592:Cross-Over Studies; D004202:Disinfectants / Q000009:adverse effects; D004311:Double-Blind Method; D004867:Equipment Design; D005260:Female; D019793:Fluorescein; D005456:Fluorescent Dyes; D005500:Follow-Up Studies; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D008297:Male; D009517:New South Wales; D011310:Preservatives, Pharmaceutical / Q000009:adverse effects*; D011446:Prospective Studies; D012828:Silicones; D013194:Staining and Labeling; D013997:Time Factors; D055815:Young Adult
D001645:Biguanides; D018639:Contact Lens Solutions; D004202:Disinfectants; D005456:Fluorescent Dyes; D011310:Preservatives, Pharmaceutical; D012828:Silicones; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; C031233:polihexanide; D019793:Fluorescein