Insulin receptor signaling in the development of neuronal structure and function.
Sensory experience plays a crucial role in regulating neuronal shape and in developing synaptic contacts during brain formation. These features are required for a neuron to receive, integrate, and transmit signals within the neuronal network so that animals can adapt to the constant changing environment. Insulin receptor signaling, which has been extensively studied in peripheral organ systems such as liver, muscle and adipocyte, has recently been shown to play important roles in the central nervous system. Here we review the current understanding of the underlying mechanisms that regulate structural and functional aspects of circuit development, particularly with respect to the role of insulin receptor signaling in synaptic function and the development of dendritic arbor morphology. The potential link between insulin receptor signaling malfunction and neurological disorders will also be discussed.
Watson School of Biological Sciences and Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA.
Shu-Ling
SL
Chiu
Hollis T
HT
Cline
D000818:Animals; D003712:Dendrites / Q000502:physiology; D009434:Neural Pathways / Q000033:anatomy & histology* / Q000254:growth & development*; D009474:Neurons / Q000166:cytology* / Q000502:physiology*; D011972:Receptor, Insulin / Q000502:physiology*; D015398:Signal Transduction; D013569:Synapses / Q000502:physiology
D011972:Receptor, Insulin