Applications of synthetic carbohydrates to chemical biology.
Access to synthetic carbohydrates is an urgent need for the development of carbohydrate-based drugs, vaccines, adjuvants as well as novel drug delivery systems. Besides traditional synthesis in solution, synthetic carbohydrates have been generated by chemoenzymatic methods as well as automated solid-phase synthesis. Synthetic oligosaccharides have proven to be useful for identifying ligands of carbohydrate-binding proteins such as C-type lectins and siglecs using glycan arrays. Furthermore, glyconanoparticles and glycodendrimers have been used for specific targeting of lectins of the immune system such as selectins, DC-SIGN, and CD22. This review focuses on how diverse carbohydrate structures can be synthetically derived and highlights the benefit of synthetic carbohydrates for glycobiology.
Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Research Campus Potsdam-Golm, 14476 Potsdam, Germany.
Bernd
B
Lepenies
Jian
J
Yin
Peter H
PH
Seeberger
D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D055808:Drug Discovery / Q000379:methods*; D054794:Glycomics / Q000379:methods*; D006801:Humans; D008956:Models, Chemical
D002241:Carbohydrates