The virologic and immunologic effects of cyclosporine as an adjunct to antiretroviral therapy in patients treated during acute and early HIV-1 infection.
Acute human immunodeficiency virus type 1 (HIV-1) infection is characterized by high levels of immune activation. Immunomodulation with cyclosporine combined with antiretroviral therapy (ART) in the setting of acute and early HIV-1 infection has been reported to result in enhanced immune reconstitution. Fifty-four individuals with acute and early infection were randomized to receive ART with 4 weeks of cyclosporine versus ART alone. In 48 subjects who completed the study, there were no significant differences between treatment arms in levels of proviral DNA or CD4(+) T cell counts. Adjunctive therapy with cyclosporine in this setting does not provide apparent virologic or immunologic benefit.
Markowitz
Martin
M
Aaron Diamond AIDS Research Center, an affiliate of Rockefeller University, New York, New York, USA. mmarkowitz@adarc.org
Vaida
Florin
F
Hare
C Bradley
CB
Boden
Daniel
D
Mohri
Hiroshi
H
Hecht
Frederick M
FM
Kalayjian
Robert C
RC
Conrad
Ann
A
Mildvan
Donna
D
Aberg
Judith
J
Hogan
Christine
C
Kilby
J Michael
JM
Balfour
Henry H
HH
Schafer
Kim
K
Richman
Douglas
D
Little
Susan
S
D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D016572:Cyclosporine / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D019562:Viral Load / Q000187:drug effects
D019380:Anti-HIV Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine