Immunohistochemical evaluation of prostaglandin E2 and vascular endothelial growth factor in canine cutaneous mast cell tumours.
Vascular endothelial growth factor (VEGF) and prostaglandin E2 (PGE-2) appear to play a critical role in tumour neovascularization. In this study, we have investigated the expression of VEGF and PGE-2 in 53 canine cutaneous mast cell tumours (MCTs). Immunohistochemistry of tissue sections revealed that VEGF and PGE-2 were expressed in all mast cell tumours studied. When the expression patterns of VEGF and PGE-2 were compared with tumour grade according to Patnaik criteria, the only significant correlation observed was between PGE-2 staining intensity and tumour pathological grade, with grade II and III tumours having higher PGE-2 staining, both in intensity and percentage of cells stained, than grade I tumours (P < 0.05).
School of Veterinary Medicine and Animal Science, UNESP, Botucatu, São Paulo, Brazil. renee@fmvz.unesp.br
R L
RL
Amorim
P
P
Pinczowski
R T
RT
Neto
S C
SC
Rahal
D000818:Animals; D015415:Biomarkers; D015232:Dinoprostone / Q000235:genetics / Q000378:metabolism*; D004283:Dog Diseases / Q000378:metabolism*; D004285:Dogs; D015972:Gene Expression Regulation, Neoplastic; D007150:Immunohistochemistry; D054705:Mastocytoma, Skin / Q000378:metabolism / Q000662:veterinary*; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics / Q000378:metabolism*
D015415:Biomarkers; D042461:Vascular Endothelial Growth Factor A; D015232:Dinoprostone