Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).
We performed a genome-wide association analysis of 1,897,764 SNPs in 1,043 German ulcerative colitis (UC) cases and 1,703 controls. We discovered new associations at chromosome 7q22 (rs7809799) and at chromosome 22q13 in IL17REL (rs5771069) and confirmed these associations in six replication panels (2,539 UC cases and 5,428 controls) from different regions of Europe (overall study sample P(rs7809799) = 8.81 x 10(-11) and P(rs5771069) = 4.21 x 10(-8), respectively).
Institute for Clinical Molecular Biology, University Hospital Schleswig-Holstein, Christian-Albrechts University, Kiel, Germany. a.franke@mucosa.de
Andre
A
Franke
Tobias
T
Balschun
Christian
C
Sina
David
D
Ellinghaus
Robert
R
Häsler
Gabriele
G
Mayr
Mario
M
Albrecht
Michael
M
Wittig
Eva
E
Buchert
Susanna
S
Nikolaus
Christian
C
Gieger
H Erich
HE
Wichmann
Jurgita
J
Sventoraityte
Limas
L
Kupcinskas
Clive M
CM
Onnie
Maria
M
Gazouli
Nicholas P
NP
Anagnou
David
D
Strachan
Wendy L
WL
McArdle
Christopher G
CG
Mathew
Paul
P
Rutgeerts
Séverine
S
Vermeire
Morten H
MH
Vatn
Michael
M
Krawczak
Philip
P
Rosenstiel
Tom H
TH
Karlsen
Stefan
S
Schreiber
D002892:Chromosomes, Human, Pair 22; D002897:Chromosomes, Human, Pair 7; D003093:Colitis, Ulcerative / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D053722:Receptors, Interleukin-17 / Q000235:genetics*; D012307:Risk Factors
C548677:IL17REL protein, human; D053722:Receptors, Interleukin-17