[Two cases of MPO-ANCA-positive otitis media associated with facial palsy].
We report two cases of otitis media positive for antimyeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) associated with facial palsy. Case 1: A 73-year-old man treated for 3 months for bilateral otitis media with effusion had left facial nerve palsy and deteriorated bone conduction hearing in both ears. Blood analysis showed elevated MPO-ANCA to 134 EU. Case 2: A 66-year-old woman treated for about one year for bilateral otitis media with effusion and fluctuating mixed hearing loss had bilateral facial nerve palsy and a blood test positive for MPO-ANCA at 67 EU. Both were diagnosed with otitis media caused by ANCA-related vasculitis. After prednisolone and cyclophosphamide administration for half a year, blood test results were negative for MPO-ANCA. Both recovered almost completely from facial nerve palsy and bone conductive hearing loss partially improved except in one hearing-impaired ear. ANCA-related vasculitis of the temporal bone should thus be considered in those with intractable otitis media and deteriorated bone conduction hearing before the occurrence of facial palsy.
Usubuchi
Hajime
H
Jichi Medical University Saitama Medical Center, Saitama.
Kodama
Kozue
K
Takizawa
Katsumi
K
Kanazawa
Takeharu
T
Ohta
Yasushi
Y
Kakizaki
Keiko
K
Iino
Yukiko
Y
D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D005158:Facial Paralysis / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D010033:Otitis Media / Q000150:complications / Q000276:immunology*; D009195:Peroxidase / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase