Neurochemical markers during selective cerebral perfusion via the right brachial artery.
Unilateral selective cerebral perfusion through right brachial artery is one of the cerebral protection methods for aortic arch repair. The purpose of this study is to determine whether cerebral perfusion through contra-lateral hemisphere is adequate or not. Seventeen consecutive patients underwent aortic arch repair using low flow antegrade selective cerebral perfusion (ASCP) through right brachial artery under moderate hypothermia. We measured S100beta and neuron-specific enolase (NSE) levels, venous O(2) saturation, lactate, and glucose from both left and right jugular vein blood samples before, during and following ASCP and cardiopulmonary bypass. There was no operative mortality or neurological complication in these patients. No significant differences were observed in S100beta and NSE levels, venous saturation, glucose and lactate between the blood samples which were gathered from both jugular veins, statistically. This technique, as far as biochemical markers are concerned, seems to provide adequate perfusion for both right and left cerebral hemispheres.
Cardiovascular Surgery Clinic, Türkiye Yüksek Ihtisas Education and Research Hospital, 06100 Sihhiye, Ankara, Turkey. maozatik@yahoo.com
Mehmet Ali
MA
Ozatik
Sabit
S
Kocabeyoglu
Seref A
SA
Küçüker
Ahmet
A
Saritas
Garip
G
Altintas
Umit
U
Kervan
Soner
S
Yavas
Mustafa
M
Paç
D000328:Adult; D000368:Aged; D001013:Aorta, Thoracic / Q000601:surgery; D001018:Aortic Diseases / Q000097:blood / Q000503:physiopathology / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D001916:Brachial Artery; D002315:Cardiopulmonary Bypass; D002406:Catheterization, Peripheral; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000097:blood / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D054022:Cerebrum / Q000098:blood supply*; D005260:Female; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D010100:Oxygen / Q000097:blood; D010477:Perfusion / Q000379:methods*; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D013997:Time Factors; D014656:Vascular Surgical Procedures / Q000009:adverse effects
D015415:Biomarkers; D001786:Blood Glucose; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D019344:Lactic Acid; D010751:Phosphopyruvate Hydratase; D010100:Oxygen