(-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu).
Enantiomerically pure cyclopentyl cytosine [(-)-carbodine 1] was synthesized from d-ribose and evaluated for its anti-influenza activity in vitro in comparison to the (+)-carbodine, (+/-)-carbodine and ribavirin. (-)-Carbodine 1 exhibited potent antiviral activity against various strains of influenza A and B viruses.
Rao
Jagadeeshwar R
JR
The University of Georgia College of Pharmacy, Athens, GA 30602, USA.
Jha
Ashok K
AK
Rawal
Ravindra K
RK
Sharon
Ashoke
A
Day
Craig W
CW
Barnard
Dale L
DL
Smee
Donald F
DF
Chu
Chung K
CK
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D003562:Cytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D004285:Dogs; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects*; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects*; D012692:Serial Passage; D013237:Stereoisomerism
D000998:Antiviral Agents; D003562:Cytidine; C033357:carbodine