Applications of synthetic carbohydrates to chemical biology.
Access to synthetic carbohydrates is an urgent need for the development of carbohydrate-based drugs, vaccines, adjuvants as well as novel drug delivery systems. Besides traditional synthesis in solution, synthetic carbohydrates have been generated by chemoenzymatic methods as well as automated solid-phase synthesis. Synthetic oligosaccharides have proven to be useful for identifying ligands of carbohydrate-binding proteins such as C-type lectins and siglecs using glycan arrays. Furthermore, glyconanoparticles and glycodendrimers have been used for specific targeting of lectins of the immune system such as selectins, DC-SIGN, and CD22. This review focuses on how diverse carbohydrate structures can be synthetically derived and highlights the benefit of synthetic carbohydrates for glycobiology.
Lepenies
Bernd
B
Max Planck Institute of Colloids and Interfaces, Department of Biomolecular Systems, Research Campus Potsdam-Golm, 14476 Potsdam, Germany.
Yin
Jian
J
Seeberger
Peter H
PH
D002241:Carbohydrates / Q000138:chemical synthesis / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques / Q000379:methods; D055808:Drug Discovery / Q000379:methods*; D054794:Glycomics / Q000379:methods*; D006801:Humans; D008956:Models, Chemical
D002241:Carbohydrates