Molecularly imprinted polymer/cryogel composites for solid-phase extraction of bisphenol A from river water and wine.
Superporous monolithic hydrogels (cryogel monoliths) are elastic, sponge-like materials that can be prepared in an aqueous medium through a cryotropic gelation technique. These monoliths show interesting properties for the development of high-throughput solid-phase extraction supports to treat large volumes of aqueous samples. In this work, a cryogel-supported molecularly imprinted solid-phase extraction approach for the endocrine disruptor bisphenol A (BPA) from river water and wine samples is presented. An imprinted polymer with molecular recognition properties for BPA was prepared in acetonitrile by thermal polymerization of a mixture of 4,4'-dihydroxy-2,2-diphenyl-1,1,1,3,3,3-trifluoropropane as a mimic template of BPA, 4-vinylpyridine and trimethylolpropane trimethacrylate in a molar ratio of 1 + 6 + 6. Fine imprinted particles (<10 microm) were embedded in a poly-acrylamide-co-N,N'-methylenbisacrylamide cryogel obtained by ammonium persulfate-induced cryopolymerization at -18 degrees C. The resulting monolithic gel was evaluated for its use as a sorbent support in an off-line solid-phase extraction approach to recover BPA from dilute aqueous samples with minimum pre-loading work-up. The optimized extraction protocol resulted in a reliable MISPE method suitable to selectively extract and preconcentrate BPA from river water and red wine samples, demonstrating the practical feasibility of cryogel-trapped imprinted polymers as solid-phase extraction materials.
Laboratory of Bioanalytical Chemistry, Department of Analytical Chemistry, University of Torino, via Giuria 5, 10125, Turin, Italy. claudio.baggiani@unito.it
Claudio
C
Baggiani
Patrizia
P
Baravalle
Cristina
C
Giovannoli
Laura
L
Anfossi
Gianfranco
G
Giraudi
D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors / Q000302:isolation & purification*; D020100:Hydrogels / Q000737:chemistry*; D054802:Molecular Imprinting / Q000379:methods*; D010636:Phenols / Q000302:isolation & purification*; D045483:Rivers / Q000737:chemistry*; D052616:Solid Phase Extraction / Q000379:methods*; D014920:Wine / Q000032:analysis*; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D020100:Hydrogels; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds