Potassium channels and neurovascular coupling.
Neuronal activity is communicated to the cerebral vasculature so that adequate perfusion of brain tissue is maintained at all levels of neuronal metabolism. An increase in neuronal activity is accompanied by vasodilation and an increase in local cerebral blood flow. This process, known as neurovascular coupling (NVC) or functional hyperemia, is essential for cerebral homeostasis and survival. Neuronal activity is encoded in astrocytic Ca(2+) signals that travel to astrocytic processes (;endfeet') encasing parenchymal arterioles within the brain. Astrocytic Ca(2+) signals cause the release of vasoactive substances to cause relaxation, and in some circumstances contraction, of the smooth muscle cells (SMCs) of parenchymal arterioles to modulate local cerebral blood flow. Activation of potassium channels in the SMCs has been proposed to mediate NVC. Here, the current state of knowledge of NVC and potassium channels in parenchymal arterioles is reviewed.
Department of Pharmacology, University of Vermont College of Medicine, Burlington, VT 05405, USA.
Kathryn M
KM
Dunn
Mark T
MT
Nelson
D000818:Animals; D001253:Astrocytes / Q000166:cytology / Q000502:physiology*; D001921:Brain / Q000098:blood supply* / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000502:physiology; D015221:Potassium Channels / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
D015221:Potassium Channels