Immunotoxicity activity of 2,6,10,15-tetrame-heptadecane from the essential oils of Clerodendron trichotomum Thunb. against Aedes aegypti L.
The leaf parts of Clerodendron trichotomum were extracted and the major essential oils composition and immunotoxicity effects were studied. The analyses were conducted by gas chromatography-mass spectroscopy (GC-MS) revealed that the essential oils of C. trichotomum (CTEO). The CTEO yield was 0.071%, and GC/MS analysis revealed that its major constituents were Hexanal (3.31%), 5-Me-3-heptanone (1.71%), 2,6,6-trime-cyclohexanone (2.23%), 2,6,10,15-tetrame-heptadecane (24.21%) and Linalool (31.2%). The essential oil had a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with an LC(50) value of 32.78 ppm and an LC(90) value of 93.72 ppm. 2,6,10,15-tetrame-heptadecane was the most toxic among the two major components (2,6,10,15-tetrame-heptadecane and Linalool), with an LC(50) value near 43.9 ppm. The results could be useful in search for newer, safer, and more effective natural immunotoxicity agents against A. aegypti.
Department of Integrative Medicine, College of Medicine, Korea University, Seoul, South Korea.
Sung-Jae
SJ
Lee
Hyung-In
HI
Moon
D000080462:Acyclic Monoterpenes; D000330:Aedes / Q000187:drug effects*; D000447:Aldehydes / Q000032:analysis; D000473:Alkanes / Q000032:analysis / Q000494:pharmacology*; D000818:Animals; D032409:Clerodendrum / Q000737:chemistry*; D003512:Cyclohexanones / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D007659:Ketones / Q000032:analysis; D007814:Larva / Q000187:drug effects; D007928:Lethal Dose 50; D039821:Monoterpenes / Q000032:analysis / Q000494:pharmacology; D009822:Oils, Volatile / Q000032:analysis / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D013729:Terpenes / Q000032:analysis / Q000494:pharmacology*
C556343:2,6,10,15-tetrame-heptadecane; D000080462:Acyclic Monoterpenes; D000447:Aldehydes; D000473:Alkanes; D003512:Cyclohexanones; D007659:Ketones; D039821:Monoterpenes; D009822:Oils, Volatile; D010936:Plant Extracts; D013729:Terpenes; C010463:n-hexanal; C018584:linalool