[Correction of free-radical oxidation as a pathogenetic approach to the treatment of acute ischemic stroke].
Free-radical oxidation is one of the central mechanisms of brain damage in acute ischemia. Results of experimental and clinical studies indicating the link between the activation of the development of free-radicals and severity of ischemic stroke are presented. The authors consider possibilities of using preparations inhibiting the production of oxygen radicals and products of lipid peroxidation which can be used for treatment of patients with ischemic stroke. Results of studies using the domestic drug mexidol in these patients are analyzed. Mexidol can be prescribed in the early period of stroke, i.e. in the pre-hospitalization stage, and used in the treatment of stroke regardless of stroke type.
Chugunov
A V
AV
Kamchatnov
P R
PR
Mikhaĭlova
N A
NA
D000975:Antioxidants / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000150:complications / Q000188:drug therapy*; D016166:Free Radical Scavengers / Q000378:metabolism*; D006801:Humans; D010084:Oxidation-Reduction; D010847:Picolines / Q000627:therapeutic use*; D020521:Stroke / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
D000975:Antioxidants; D016166:Free Radical Scavengers; D010847:Picolines; C070020:emoxypine succinate