Cytotoxic substances from two species of Japanese sea hares: chemistry and bioactivity.
From the sea hares belonging to two genera, Aplysia and Dolabella, a variety of new cytotoxic substances were isolated as minute constituents: their chemical structures were determined and their cytotoxicity was evaluated. Regarding the highly cytotoxic substances, further chemical and biological studies were performed that included their asymmetric chemical synthesis and elucidation of biological characteristics such as antitumor activity.
Yamada
Kiyoyuki
K
Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan.
Ojika
Makoto
M
Kigoshi
Hideo
H
Suenaga
Kiyotake
K
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001048:Aplysia / Q000737:chemistry*; D016923:Cell Death / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D007564:Japan; D010455:Peptides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014118:Toxins, Biological / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity
D000970:Antineoplastic Agents; D010455:Peptides; D014118:Toxins, Biological