Switch NFix developmental myogenesis.
During development, skeletal muscles adapt to stage-specific functional and metabolic challenges by switching the expression of specific subset of genes. The mechanism that governs these changes is still enigmatic. In a recent issue of Cell, Messina and coworkers shed light on this issue through the identification of a transcription factor--NFix--that coordinates the switch in gene expression at the transition from embryonic to fetal myoblasts.
Dulbecco Telethon Institute , IRCCS Fondazione Santa Lucia and European Brain Research Institute, 00161 Roma, Italy.
Daniela
D
Palacios
Pier Lorenzo
PL
Puri
D000818:Animals; D047108:Embryonic Development / Q000235:genetics / Q000502:physiology; D051379:Mice; D024510:Muscle Development / Q000235:genetics / Q000502:physiology*; D018482:Muscle, Skeletal / Q000196:embryology / Q000502:physiology; D051839:NFI Transcription Factors / Q000235:genetics / Q000502:physiology*; D012038:Regeneration / Q000235:genetics / Q000502:physiology
D051839:NFI Transcription Factors; C497650:Nfix protein, mouse