Impact of cancer patients' disease awareness on their family members' health-related quality of life: a cross-sectional survey.
BACKGROUND
Conflicting results exist concerning disease knowledge and patients' quality of life (QOL) while there is very limited information concerning the impact of awareness on caregivers' health-related quality of life. The aim of this study was to explore the influence of disease awareness on both cancer patients and their caregivers during the period of chemotherapy.


METHODS
Two hundred and twelve cancer patient-caregiver dyads completed the QOL SF-36 instrument on the day of chemotherapy. Hierarchical multiple linear regression analysis was performed.


RESULTS
Physical component parameters were significantly higher in the family members (p<0.001), while their mental component was lower than cancer patients. Younger patients, females, and of higher educational status were more frequently aware of their disease status while patients with gastrointestinal cancer were more likely to be unaware. Disease knowledge seems to exert a negative influence on patients' physical and mental parameters while lack of awareness affects adversely caregivers' vitality, social function, emotional role, and mental health. Multiple regression analysis confirmed disease awareness affected reversely patients' and caregivers' mental QOL while the counter-influence of the dyad was revealed.


CONCLUSIONS
A holistic approach to cancer management should be followed. Patient's treatment is the major medical concern, but health system and professionals should be involved in the mental and physical support of caregivers as well. Tailored interventions that focus on the support of the dyad patient-caregiver should be developed.
Papadopoulos
A
A
Second Department of Internal Medicine, Medical School, Attikon, University General Hospital, Athens, Greece; Faculty of Social Sciences, Hellenic Open University, Patras, Greece. docpapado@yahoo.gr
Vrettos
I
I
Kamposioras
K
K
Anagnostopoulos
F
F
Giannopoulos
G
G
Pectasides
D
D
Niakas
D
D
Economopoulos
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000627:therapeutic use; D017028:Caregivers / Q000523:psychology*; D003430:Cross-Sectional Studies; D005190:Family; D005260:Female; D007722:Health Knowledge, Attitudes, Practice; D006304:Health Status; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000451:nursing / Q000523:psychology*; D011594:Psychometrics; D011788:Quality of Life / Q000523:psychology*; D018434:Sickness Impact Profile; D012944:Social Support; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D055815:Young Adult
D000970:Antineoplastic Agents