A United Kingdom Haemophilia Centre Doctors' Organization guideline approved by the British Committee for Standards in Haematology: guideline on the use of prophylactic factor VIII concentrate in children and adults with severe haemophilia A.
Consensus-based guidelines supported by the literature are presented on the role of prophylactic administration of factor VIII concentrate in children and adults with severe haemophilia A. The timing of initiation of prophylaxis, the choice of prophylactic regimen, monitoring, management of breakthrough bleeding and education of the patient and family are discussed.
St. James's University Hospital, Leeds, UK. michael.richards@leedsth.nhs.uk
Michael
M
Richards
Michael
M
Williams
Elizabeth
E
Chalmers
Ri
R
Liesner
Peter
P
Collins
Vicky
V
Vidler
John
J
Hanley
D000328:Adult; D002648:Child; D003029:Coagulants / Q000627:therapeutic use*; D016903:Drug Monitoring / Q000379:methods; D019317:Evidence-Based Medicine; D005169:Factor VIII / Q000627:therapeutic use*; D006467:Hemophilia A / Q000150:complications / Q000188:drug therapy*; D006470:Hemorrhage / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008297:Male; D055815:Young Adult
D003029:Coagulants; D005169:Factor VIII