Pharmacogenetics of asthma in children.
Allergic diseases such as bronchial asthma and atopic dermatitis develop by a combination of genetic and environmental factors. Several candidate causative genes of asthma and atopy have been reported as the genetic factors. The clinical features of patients and causes of diseases vary. Therefore, personalized medicine (tailor-made medicine) is necessary for the improvement of quality of life (QOL) and for asthma cure. Pharmacogenetics is very important for personalized medicine. Here, we present the genetics and pharmacogenetics of asthma in children. Finally, we show the guideline for personalized medicine for asthma, particularly in childhood, including the pharmacogenetics of anti-asthmatic drugs, preliminarily produced by the authors.
Kondo
Naomi
N
Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan.
Matsui
Eiko
E
Nishimura
Akane
A
Kaneko
Hideo
H
Pharmacogenetics; asthma; individualized medicine