Prenatal exposure to inflammation induced by zymosan results in activation of intrarenal renin-angiotensin system in adult offspring rats.
Prenatal exposure to inflammation produces offspring that are hypertensive in adulthood. The present study was to explore the role of intrarenal renin-angiotensin (Ang) system in the development of hypertension programmed by prenatal exposure to zymosan. Pregnant rats were randomly divided into control group and zymosan group (n = 6). Rats in these two groups were administered intraperitoneally with 0.5 ml vehicle and 2.37 mg/kg zymosan, respectively, on the eighth, tenth, and 12th day during gestation. The results showed the glomerular number and creatinine clearance rate decreased significantly in offspring of zymosan-treated rats. The renal cortex renin mRNA expression, Ang II-positive cells in renal cortex, and Ang II expression in renal medulla increased significantly in offspring of zymosan-treated rats at 7, 16, and 25 weeks of age. The plasma renin activity and Ang II concentration were unchanged. In conclusion, prenatal exposure to zymosan resulted in the activation of intrarenal renin-Ang system in adult offspring rats.
Institute of Materia Medica and Department of Pharmaceutics, College of Pharmacy, Third Military Medical University, Chongqing, China.
Xue-Qin
XQ
Hao
Hai-Gang
HG
Zhang
Shu-Hui
SH
Li
Yi
Y
Jia
Ya
Y
Liu
Jian-Zhi
JZ
Zhou
Yan-Ling
YL
Wei
Li-Yun
LY
Hao
Yuan
Y
Tang
Min
M
Su
Xiao-Hui
XH
Li
D000804:Angiotensin II / Q000097:blood / Q000235:genetics; D000818:Animals; D001794:Blood Pressure; D003404:Creatinine / Q000378:metabolism; D005260:Female; D015870:Gene Expression; D006973:Hypertension / Q000097:blood / Q000378:metabolism / Q000503:physiopathology*; D007249:Inflammation / Q000473:pathology / Q000503:physiopathology*; D007677:Kidney Function Tests; D007678:Kidney Glomerulus / Q000473:pathology / Q000503:physiopathology*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012333:RNA, Messenger / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012083:Renin / Q000097:blood / Q000235:genetics / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000502:physiology*; D015054:Zymosan / Q000276:immunology
D012333:RNA, Messenger; D000804:Angiotensin II; D015054:Zymosan; D003404:Creatinine; D012083:Renin