Age-related survival and clinical features in systemic sclerosis patients older or younger than 65 at diagnosis.
OBJECTIVE
To analyse the differences in SSc clinical features and survival in patients aged > or = 65 years compared with young SSc patients.


METHODS
Of a total of 319 SSc patients, we identified 67 (21%) patients aged >65 years. Demographical data such as SSc subsets, the cutaneous complaint, internal organ involvement and the causes of morbidity and mortality were collected. Results of the elderly and young patients were compared.


RESULTS
There were 61 (91%) women and 6 (9%) men aged > or = 65 years. The limited SSc (lSSc) subset was more prevalent in elderly than in young patients (74.6 vs 54%, P = 0.002). Pulmonary disease (86.6% in elderly vs 73.8% in young patients, P = 0.034) and cardiac involvement (70.1% in elderly vs 49.6% in young patients, P = 0.004) were significantly more prevalent in elderly patients. In contrast, signs of oesophageal involvement (43.3% in elderly vs 57.5% in young patients, P = 0.040) were less frequent in aged patients. In addition, pulmonary and heart disease appeared significantly earlier after the diagnosis in patients aged > or = 65 years. Mortality was significantly higher in elderly than in young patients (35.8 vs 19%, P = 0.005), but when standardized mortality ratios (SMRs) were analysed, there was no significant mortality increase in the elderly.


CONCLUSIONS
In elderly patients, the lSSc subset is more prevalent than the diffuse. Pulmonary and cardiac involvement are more prevalent in aged patients and appears sooner after the disease diagnosis. SSc is clearly related to increased mortality, although it is not significant in the elderly group.
Internal Medicine Department, Vall d'Hebron University Hospital and Universitat Autònoma de Barcelona, Barcelona, Spain. macperez@vhebron.net
Carmen
C
Pérez-Bocanegra
Roser
R
Solans-Laqué
Carmen P
CP
Simeón-Aznar
Mercedes
M
Campillo
Vicente
V
Fonollosa-Pla
Miquel
M
Vilardell-Tarrés
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002423:Cause of Death; D018450:Disease Progression; D005260:Female; D006331:Heart Diseases / Q000150:complications / Q000401:mortality / Q000503:physiopathology*; D006801:Humans; D008171:Lung Diseases / Q000150:complications / Q000401:mortality / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000150:complications / Q000401:mortality / Q000503:physiopathology*; D012720:Severity of Illness Index; D015996:Survival Rate