Combination of urinary kidney injury molecule-1 and interleukin-18 as early biomarker for the diagnosis and progressive assessment of acute kidney injury following cardiopulmonary bypass surgery: a prospective nested case-control study.
The aim of this nested case-control study was to assess the combined use of urinary kidney injury molecule (KIM)-1 and interleukin (IL)-18 for acute kidney injury (AKI) after cardiopulmonary bypass surgery (CPB). From a cohort of 122 subjects who underwent CPB, serial urinary KIM-1 and IL-18 concentrations were determined in 30 AKI and 92 non-AKI patients. An increased level of urinary KIM-1 was associated with the occurrence of AKI, whereas an increased level of IL-18 was related to progressive AKI. The combination of these two biomarkers facilitates the early diagnosis and assessment of the likely progression of AKI after CPB.
Division of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, China.
Xin-Ling
XL
Liang
Shuang-Xin
SX
Liu
Yuan-Han
YH
Chen
Li-Jun
LJ
Yan
Heng
H
Li
Hui-Jie
HJ
Xuan
Yong-Zheng
YZ
Liang
Wei
W
Shi
D000208:Acute Disease; D000328:Adult; D015415:Biomarkers / Q000652:urine; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D016022:Case-Control Studies; D018450:Disease Progression; D042241:Early Diagnosis; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D020382:Interleukin-18 / Q000652:urine*; D007674:Kidney Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D008562:Membrane Glycoproteins / Q000652:urine*; D008875:Middle Aged; D011991:Receptors, Virus; D055815:Young Adult
D015415:Biomarkers; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D020382:Interleukin-18; D008562:Membrane Glycoproteins; D011991:Receptors, Virus