Painting a perspective on the landscape of nucleosome positioning.
DNA sequence influences the position of nucleosomes and chromatin architecture. The extent to which underlying DNA sequence affects nucleosome positioning is currently a topic of considerable discussion and active experimentation. To contribute to the discussion, I will outline a few of the methods, data and arguments that I find compelling and believe will ultimately resolve the question of what positions nucleosomes. Basically, I will give a portrait of my current perspective on what influences the landscape of nucleosome positioning and chromatin architecture.
Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA. stevenj@byu.edu
Steven M
SM
Johnson
D000818:Animals; D001483:Base Sequence; D017173:Caenorhabditis elegans / Q000235:genetics; D042002:Chromatin Assembly and Disassembly / Q000235:genetics; D016678:Genome / Q000235:genetics; D006657:Histones / Q000378:metabolism; D009690:Nucleic Acid Conformation; D009707:Nucleosomes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D017422:Sequence Analysis, DNA
D006657:Histones; D009707:Nucleosomes