HLA-B27-associated bilateral Ménière disease.
We describe 2 cases of bilateral Ménière disease with features resembling autoimmune inner ear disease in patients who were found to be carriers of human leukocyte antigen (HLA) B27. For immunohistochemical analysis, mouse inner ear sections were used as the tissue substrate for reaction with serum. Both patients demonstrated an increased immunofluorescence reaction compared with a normal control. We suggest that an antibody-mediated mechanism may be responsible for HLA-B27-associated Ménière disease.
Rawal
Shamila G
SG
Department of Otolaryngology-Head and Neck Surgery, University of Illinois at Chicago, Chicago, IL, USA.
Thakkar
Kunal H
KH
Ziai
Kasra
K
Santi
Peter A
PA
Djalilian
Hamid R
HR
D000287:Administration, Topical; D000368:Aged; D000483:Alleles; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003907:Dexamethasone / Q000627:therapeutic use*; D005838:Genotype; D015796:HLA-B27 Antigen / Q000235:genetics*; D006312:Hearing Loss, Bilateral / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008297:Male; D008575:Meniere Disease / Q000150:complications / Q000188:drug therapy* / Q000235:genetics*; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use*; D012720:Severity of Illness Index; D014717:Vertigo / Q000175:diagnosis / Q000209:etiology
D000893:Anti-Inflammatory Agents; D015796:HLA-B27 Antigen; D003907:Dexamethasone; D011241:Prednisone