Long-term survival and PSA control with radiation and immunotherapy for node positive prostate cancer.
We describe a patient with node positive prostate cancer treated with radiation, androgen deprivation, and immunotherapy with long-term overall survival and PSA control. ELISPOT immunoassay studies demonstrated PSA specific T-cells prior to starting vaccine therapy suggesting that this positive response may be related to an improved antitumor immune response of the patient, increased immunogenicity of the tumor, or decreased activation of immune escape pathways. Further evaluation of therapeutic cancer vaccines in combination with radiation and hormonal therapy in the definitive management of prostate cancer is warranted.
Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
M
M
Kamrava
Kwong Y
KY
Tsang
R A
RA
Madan
A
A
Kaushal
C N
CN
Coleman
J
J
Gulley
D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D000813:Anilides / Q000008:administration & dosage; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D018122:B7-1 Antigen / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D019496:Cancer Vaccines; D017273:Goserelin / Q000008:administration & dosage; D006801:Humans; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D009570:Nitriles / Q000008:administration & dosage; D017430:Prostate-Specific Antigen / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D015202:Protein Engineering; D011860:Radiography, Abdominal; D011878:Radiotherapy; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D014105:Tosyl Compounds / Q000008:administration & dosage; D036761:Ultrasound, High-Intensity Focused, Transrectal; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000235:genetics / Q000378:metabolism
D000813:Anilides; D018931:Antineoplastic Agents, Hormonal; D018122:B7-1 Antigen; D019496:Cancer Vaccines; D009570:Nitriles; D014105:Tosyl Compounds; D014614:Vaccines, Synthetic; D017273:Goserelin; C053541:bicalutamide; D017430:Prostate-Specific Antigen