RECK expression in the rat ventral prostate: response to castration involves a balance between epithelial and stromal expression.
RECK is expressed in the rat ventral prostate. The amount of mRNA increased after castration. In situ hybridization and immunohistochemistry demonstrated a transition from epithelial to stromal expression. This demonstrates that stromal cells upregulate RECK expression to regulate matrix metalloproteinases activity responsible for extracellular matrix (ECM) changes occurring after castration.
Peters
Helene
H
Department of Anatomy, Cell Biology, Physiology and Biophysics, Institute of Biology, State University of Campinas, Campinas SP, Brazil.
Augusto
Taize Machado
TM
Bruni-Cardoso
Alexandre
A
Carvalho
Hernandes F
HF
D000818:Animals; D004847:Epithelial Cells / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D058851:GPI-Linked Proteins / Q000096:biosynthesis / Q000235:genetics; D008297:Male; D020782:Matrix Metalloproteinases / Q000378:metabolism; D009919:Orchiectomy; D011467:Prostate / Q000166:cytology / Q000201:enzymology / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D017154:Stromal Cells / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000096:biosynthesis* / Q000235:genetics
D058851:GPI-Linked Proteins; C529735:Reck protein, rat; D025521:Tumor Suppressor Proteins; D020782:Matrix Metalloproteinases