Decreased quinolone susceptibility in high percentage of Enterobacter cloacae clinical isolates caused only by Qnr determinants.
The prevalence of qnr genes was similar in the ciprofloxacin-resistant and ciprofloxacin-susceptible Enterobacter cloacae isolates, and no amino acid change in quinolone resistance-determining regions was found in any of the 21 qnr-positive but ciprofloxacin-susceptible strains. Qnr may thus be present before the development of higher-level resistance from target mutations.
Zhao
Xu
X
Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai 200040, PR China.
Xu
Xiaogang
X
Zhu
Demei
D
Ye
Xinyu
X
Wang
Minggui
M
D019943:Amino Acid Substitution / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics*; D002681:China / Q000453:epidemiology; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D024881:Drug Resistance, Bacterial; D016972:Enterobacter cloacae / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D015363:Quinolones / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D015363:Quinolones