Intramolecular cyclization of 1-(2-arylethyl)tetrahydro-6-hydroxy-1H-pyrimidin-2-thiones: effect of substituents on reactivity.
Convenient synthetic procedures for 1,2,3,6,7, 11b-hexahydro-4H-pyrimido[6, 1 -a] isoquinolin-4-thiones and 2,3,6,7,12,12b-hexahydro-1H-pyrimido[1',6':1,2]pyrido[3,4-b]indole-4-thiones have been developed. Structural factors which influence on a cascade cyclization process have been elucidated.
Fisuyk
Alexander S
AS
Omsk FM Dostoevsky State University, Mira Prospect 55A, Omsk 644077, Russia.
Mukanov
Aleksey Y
AY
Poendaev
Nikolay V
NV
D002625:Chemistry, Organic / Q000379:methods*; D003500:Cyclization; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry; D013871:Thiones / Q000138:chemical synthesis* / Q000737:chemistry*
D007546:Isoquinolines; D013871:Thiones