Supernormal electro-oculograms in patients with neurofibromatosis type 1.
OBJECTIVE
To asses the retinal pigment epithelium (RPE) function measured by EOG testing in patients with neurofibromatosis type 1 (NF-1). Our preliminary EOG results suggested dysfunction of the RPE in individuals with NF-1. In order to confirm our initial results we performed EOG examination on a larger group of NF-1 patients.


METHODS
Studies were performed on 36 patients with clinically diagnosed NF-1 and compared to normal healthy controls.


METHODS
Standard EOG recordings were performed in accordance with the International Society for Clinical Electrophysiology of Vision (ISCEV) standards.


RESULTS
In NF-1 patients the Arden indexes of the EOG test were significantly higher primarily due to the lower values of dark troughs. Supernormal EOGs (exceeding the value of the mean + 2 SD from the control group) were present in 58% of NF-1 patients.


CONCLUSIONS
Dysfunction of the RPE is a characteristic feature of individuals with NF-1.
Lubiński
Wojciech
W
Clinic of Ophthalmology, Pomeranian Medical University, Szczecin, Poland. lubinski@pro.onet.pl.
Zajaczek
Stanisław
S
Sych
Zbigniew
Z
Penkala
Krzysztof
K
Palacz
Olgierd
O
Lubiński
Jan
J