A facile total synthesis of hainanensine via an unusual rearrangement--annulation cascade.
A facile total synthesis of hainanensine (1), a structurally unique Cephalotaxus alkaloid, via an effective acid-mediated rearrangement/Friedel-Crafts annulation cascade (7a/7b --> 8a/8b), is described.
Zhang
Zhi-Wei
ZW
State Key Laboratory of Applied Organic Chemistry, Lanzhou Universty, Lanzhou 730000, China.
Li
Wei-Dong Z
WD
D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D018360:Crystallography, X-Ray; D006248:Harringtonines / Q000138:chemical synthesis* / Q000737:chemistry
D001688:Biological Products; D006248:Harringtonines; C030424:hainanensine