Evaluation of the biocompatibility of novel peptide hydrogel in rabbit eye.
A peptide containing a RGD (arginine-glycine-aspartic acid) sequence as well as a hydrophobic N-fluorenyl-9-methoxycarbonyl (FMOC) tail was prepared via a standard FMOC solid-phase peptide synthesis technique. The supramolecular self-assembly of such peptide through pi-pi stacking from FMOC tail can transfer the peptide aqueous solution into a three-dimensional hydrogel. The biocompatibility of the peptide hydrogel was evaluated via clinical follow-up and histological analysis. The data obtained demonstrated that the peptide hydrogel exhibited good biocompatibility when injected to the subconjunctival space and anterior chamber of rabbit, indicating a potential application in ophthalmology as an implantable drug delivery system for the treatment to ocular anterior segment diseases such as glaucoma, iridocyclitis, and keratopathy.
Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Liang
L
Liang
Xiao-Ding
XD
Xu
Chang-Sheng
CS
Chen
Jia-Hua
JH
Fang
Fa-Gang
FG
Jiang
Xian-Zheng
XZ
Zhang
Ren-Xi
RX
Zhuo
D000818:Animals; D005123:Eye; D020100:Hydrogels / Q000138:chemical synthesis / Q000494:pharmacology*; D015918:Infusion Pumps, Implantable; D008422:Materials Testing; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D011817:Rabbits
D020100:Hydrogels; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid