A new prenylated flavanonol from Seseli annuum roots showing protective effect on human lymphocytes DNA.
A new prenylated flavanonol named seselinonol (1) was isolated from the roots of Seseli annuum, together with the well-known biologically active polyacetylenes falcarinol (2) and falcarindiol (3), and the prenylated furanocoumarin phellopterin (4). Its structure was elucidated by extensive spectroscopic analysis, including HR-ESI-MS, 1D- and 2D-NMR. Seselinonol and phellopterin were tested for in vitro protective effect on chromosome aberrations in peripheral human lymphocytes using cytochalasin-B blocked micronucleus (CBMN) assay. The new compound exerted a beneficial effect by decreasing DNA damage of human lymphocytes.
Vucković
Ivan
I
Institute of Chemistry, Technology and Metallurgy, Njegoseva 12, 11000 Belgrade, Serbia.
Vajs
Vlatka
V
Stanković
Miroslava
M
Tesević
Vele
V
Milosavljević
Slobodan
S
D019661:Apiaceae / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004247:DNA / Q000378:metabolism*; D053280:Diynes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D044948:Flavonols / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D045782:Hemiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D018517:Plant Roots / Q000737:chemistry
D003374:Coumarins; D053280:Diynes; D005233:Fatty Alcohols; D044948:Flavonols; D045782:Hemiterpenes; C550153:seselinonol; C018541:falcarinol; C104601:phellopterin; C034379:falcarindiol; D004247:DNA