In vitro activity of a new isothiazoloquinolone, ACH-702, against Mycobacterium tuberculosis and other mycobacteria.
In this work, we describe the activity of ACH-702 against clinical isolates of Mycobacterium tuberculosis and six different nontuberculous mycobacteria. The MIC(50) and MIC(90) of both susceptible and drug-resistant M. tuberculosis strains tested were 0.0625 and 0.125 microg/ml, respectively. The MIC(50) and MIC(90) values for Mycobacterium fortuitum isolates were 0.0625 microg/ml in both cases; Mycobacterium avium complex isolates showed MIC(50) and MIC(90) values of 0.25 and 4 microg/ml, respectively.
Servicio de Dermatología, Hospital Universitario José E. González, Monterrey, Nuevo León, México.
Carmen A
CA
Molina-Torres
Jorge
J
Ocampo-Candiani
Adrian
A
Rendón
Michael J
MJ
Pucci
Lucio
L
Vera-Cabrera
D000995:Antitubercular Agents / Q000494:pharmacology*; D015195:Drug Design; D024881:Drug Resistance, Bacterial / Q000187:drug effects*; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D009162:Mycobacterium avium / Q000187:drug effects*; D015269:Mycobacterium avium Complex / Q000187:drug effects; D016926:Mycobacterium chelonae / Q000187:drug effects; D019907:Mycobacterium fortuitum / Q000187:drug effects; D019909:Mycobacterium kansasii / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009170:Nontuberculous Mycobacteria / Q000187:drug effects; D015363:Quinolones / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*
C550937:ACH 702; D000995:Antitubercular Agents; D015363:Quinolones; D013844:Thiazoles