[Mechanisms of HIV replication and anti-HIV drug action].
HIV is the causative agent for AIDS. This replicates in CD4+ T cells and macrophages, and produces the infectious particles from multiple intracellular events. Chemicals against these intracellular events, especially reverse transcription, integration, and processing, have been successfully generated and HIV replication and disease progression can be effectively suppressed by combination administration of the chemicals. To understand anti-HIV drugs, we firstly illustrate the life cycles of HIV replication and then, summarize the enzymatic mechanisms of reverse transcriptase, integrase, and protease, and the inhibitor actions.
Koyanagi
Yoshio
Y
Laboratory of Viral Pathogenesis, Center for AIDS, Institute for Virus Research, Kyoto University.
Watanabe
Tadashi
T
D019380:Anti-HIV Agents / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects* / Q000502:physiology*; D014779:Virus Replication / Q000187:drug effects*
D019380:Anti-HIV Agents