Clinical and histologic evaluation of calcium-phosphate bone cement in interproximal osseous defects in humans: a report in four patients.
This study evaluated the clinical and histologic results of a calcium phosphate bone cement in the treatment of human periodontal intraosseous defects. Four patients with chronic advanced periodontitis in whom treatment with complete dentures was planned were recruited. The cement was implanted in one defect per subject with a presurgical probing depth of at least 7 mm and a radiographic bone defect of 4 mm or more. Patients were seen every 2 weeks for periodontal maintenance. At 6 months, clinical measurements were repeated and the tooth was removed en bloc for histologic processing. Results demonstrated that all defects resulted in probing depth reduction and, at three of the four defects, in clinical attachment level gain. However, no site showed periodontal regeneration. There was no new bone formation. New cementum and connective tissue were limited to 0.2 mm or less. Large deposits of the bone cement were noted encapsulated in connective tissue.
Periodontics Department, The University of Texas Health Science Center at San Antonio, TX 78229-3900, USA. mellonig@uthscsa.edu
James T
JT
Mellonig
Pilar
P
Valderrama
David L
DL
Cochran
D016301:Alveolar Bone Loss / Q000628:therapy*; D001843:Bone Cements / Q000737:chemistry / Q000627:therapeutic use*; D001861:Bone Regeneration; D018786:Bone Substitutes; D002119:Calcium Carbonate; D002130:Calcium Phosphates; D055113:Chronic Periodontitis / Q000628:therapy*; D012534:Dental Scaling; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010710:Phosphates; D016896:Treatment Outcome
D001843:Bone Cements; D018786:Bone Substitutes; D002130:Calcium Phosphates; D010710:Phosphates; D002119:Calcium Carbonate; C018279:sodium phosphate