[Pathogenesis and treatment of non-alcoholic fatty liver disease].
In order to explore the pathogenesis of non-alcoholic fatty liver disease (NAFLD), and to find the best evidence for clinical practice, recent literature about the pathogenesis and treatment of NAFLD was analyzed, and it was found that the generation of reactive oxygen species (ROS) is the most important factor in development of NAFLD. Based on insulin resistance (IR), generation of ROS is a central link in the course of "two hits". Other factors, such as leptin resistance, caspase-3, Fas and its ligand, peripheral natural killer T cells, cyclooxygenase-2, metabolic nuclear receptors, hepatic deposition of iron, ferritin, haptoglobin, retinol binding protein 4, imbalance of intestinal flora, mitochondrial dysfunction and endoplasmic reticulum stress, also contribute to the progress of NAFLD. In the treatment of NAFLD, beside the conventionally used methods such as IR improvement, antioxidation and lipid metabolism improvement, other medicines such as nuclear metabolism ligands or activators, iron-chelating agents and syndrome differentiation treatment in traditional Chinese medicine also have good efficacy.
Xie
Ping
P
Department of Liver Diseases, Shanghai Public Clinical Health Center, Fudan University, Shanghai 201508, China.
Zhou
Xin-xi
XX
Zhang
Qin
Q
D000975:Antioxidants / Q000378:metabolism; D005234:Fatty Liver / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000378:metabolism; D050356:Lipid Metabolism; D008516:Medicine, Chinese Traditional; D065626:Non-alcoholic Fatty Liver Disease
D000975:Antioxidants; D020738:Leptin