Synthesis of 1-octadecanol-modified water-swelling polyurethane hydrogels as vaginal drug-delivery vehicle.
The purpose of this work was to develop a novel polyurethane hydrogel system for sustained drug release, which could be used as a vaginal drug-delivery vehicle. The blank polyurethane hydrogels were synthesized by a polyol oligomeric, a diisocyanate and a triol (used as cross-linking agent). In order to improve the swelling ability of a polyurethane hydrogel, a small amount of 1-octadecanol was added. Additionally, the structure, mechanical properties and thermal properties of polymers were assessed by FT-IR, WAXD, DSC and mechanical tests. The results show that no more than 2.5 wt% of 1-octadecanol additives is sufficient to affect the release profile without changing the structure and mechanical properties of the polyurethane hydrogels obviously. Tinidazole was chosen as a model drug, the release data of drug from polyurethane hydrogels were fitted using the Ritger-Peppas equation and the result showed that it was non-Fickian diffusion, which means that the drug release was controlled by both swollen control and diffusion control. In conclusion, our work proves that the synthesized polyurethane hydrogel modified by 1-octadecanol may be a promising sustained release drug carrier.
Centre for Drug Discovery, China Pharmaceutical University, Nanjing 210009, P. R. China.
Dechuang
D
Yuan
Caoyun
C
Ju
Song
S
Ding
Xiang
X
Jing
Can
C
Zhang
D000282:Administration, Intravaginal; D003692:Delayed-Action Preparations; D004058:Diffusion; D016503:Drug Delivery Systems; D005233:Fatty Alcohols / Q000737:chemistry; D005260:Female; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis* / Q000737:chemistry; D014677:Pharmaceutical Vehicles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D011140:Polyurethanes / Q000737:chemistry; D014867:Water / Q000737:chemistry
D003692:Delayed-Action Preparations; D005233:Fatty Alcohols; D020100:Hydrogels; D014677:Pharmaceutical Vehicles; D011108:Polymers; D011140:Polyurethanes; C024617:polyol; D014867:Water; C009316:stearyl alcohol