N,N'-methylenediimidazolium salts: from self-assembly to an efficient DNAse protection system.
We have developed N,N'-dialkylmethylenediimidazolium salts ([C(n)C(n)DIM][X]2) that self-organize into multilayered cationic vesicles and can interact with DNA. These preorganized systems form complexes with linear DNA and protect it from DNase I cleavage.
Department of Chemistry, Université de Montréal, C.P. 6128 Succursale Centre-ville, Montréal, Québec, H3C 3J7 (Canada), Fax: (+1) 514-343-7586.
Christophe
C
Pardin
Loïc
L
Leclercq
Andreea R
AR
Schmitzer
D002412:Cations; D004247:DNA / Q000378:metabolism*; D003850:Deoxyribonuclease I / Q000378:metabolism*; D006860:Hydrogen Bonding; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D010957:Plasmids / Q000737:chemistry; D012492:Salts / Q000138:chemical synthesis / Q000737:chemistry
D002412:Cations; D007093:Imidazoles; D012492:Salts; D004247:DNA; D003850:Deoxyribonuclease I
DNA interactions; diimidazolium salts; enzymes; self-assembly; vesicles