Experimentally based sea urchin gene regulatory network and the causal explanation of developmental phenomenology.
Gene regulatory networks for development underlie cell fate specification and differentiation. Network topology, logic and dynamics can be obtained by thorough experimental analysis. Our understanding of the gene regulatory network controlling endomesoderm specification in the sea urchin embryo has attained an advanced level such that it explains developmental phenomenology. Here we review how the network explains the mechanisms utilized in development to control the formation of dynamic expression patterns of transcription factors and signaling molecules. The network represents the genomic program controlling timely activation of specification and differentiation genes in the correct embryonic lineages. It can also be used to study evolution of body plans. We demonstrate how comparing the sea urchin gene regulatory network to that of the sea star and to that of later developmental stages in the sea urchin, reveals mechanisms underlying the origin of evolutionary novelty. The experimentally based gene regulatory network for endomesoderm specification in the sea urchin embryo provides unique insights into the system level properties of cell fate specification and its evolution.
Ben-Tabou de-Leon
Smadar
S
Division of Biology 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
Davidson
Eric H
EH
Division of Biology 156-29, California Institute of Technology, Pasadena, CA 91125, USA.
D000818:Animals; D004447:Echinodermata / Q000196:embryology / Q000235:genetics; D019143:Evolution, Molecular; D018507:Gene Expression Regulation, Developmental; D053263:Gene Regulatory Networks; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology; D012617:Sea Urchins / Q000196:embryology* / Q000235:genetics*; D013045:Species Specificity; D049490:Systems Biology; D051153:Wnt Proteins / Q000235:genetics / Q000502:physiology
D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D051153:Wnt Proteins; C064045:delta protein
evolution; gene regulation in development; systems level properties