Collagenous myofibroblastic tumor of the mandible: case report of a unique locally aggressive neoplasm.
We report a locally aggressive collagenous myofibroblastic neoplasm of the mandible in an 18-year-old male. Clinically, the lesion presented with rapid growth and irregular mandibular bone destruction. Grossly, the tumor was 10 cm in greatest dimension, light-tan, firm, and involving the posterior one-thirds of the body and inferior half of the left mandibular ramus. Histologically, the lesion was composed of a loose spindle cell proliferation interspersed with periodic dense bands of collagen. The spindle cells reacted positively to smooth muscle actin, calponin, and focally to desmin and were negative for S-100, pan-cytokeratin, CD99, CD34 and caldesmon, supporting myofibroblastic derivation. At our 4 year follow-up, the patient remained free of local recurrence and surgery related complications. The clinicopathologic findings and the differential diagnosis of this lesion is presented and discussed.
Nash
Jason W
JW
Department of Pathology, The University of Texas M.D. Anderson Cancer Center, Unit 85, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
Hessel
Amy C
AC
Vigneswaran
Nadarajah
N
El-Naggar
Adel K
AK
D000199:Actins / Q000378:metabolism; D000293:Adolescent; D014408:Biomarkers, Tumor / Q000378:metabolism; D044963:Biopsy, Fine-Needle; D002135:Calcium-Binding Proteins / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D003893:Desmin / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008334:Mandible / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D008339:Mandibular Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008840:Microfilament Proteins / Q000378:metabolism; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology; D009379:Neoplasms, Muscle Tissue / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D000096985:Calponins
D000199:Actins; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D003094:Collagen; D003893:Desmin; D008840:Microfilament Proteins; D000096985:Calponins