Circulating angiogenic factors and their association with birth outcomes in preeclampsia.
This study was designed to test the hypothesis that altered angiogenic factors together with increased oxidative stress and reduced docosahexaenoic acid (DHA) levels may be associated with altered birth outcome parameters. To test this hypothesis, levels of plasma vascular endothelial growth factor (VEGF), placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), the oxidative stress marker malondialdehyde (MDA) and fatty acids were estimated in women with preeclampsia and their cord samples and compared with those in normotensive women. The association of these parameters with birth outcome was also examined. Our results show that in preeclamptic women, maternal plasma VEGF and PlGF levels were lower, whereas sFlt-1 levels were higher (P<0.05 for all) than in normotensive women. In contrast, cord plasma VEGF levels were higher (P<0.05) in preeclamptic women, whereas there was no difference in sFlt-1 levels. Plasma DHA levels in both the mother and cord were lower (P<0.05) in the preeclamptic group compared with normotensive women. Maternal plasma sFlt-1 levels were positively (n=23, r=0.415, P=0.039) associated with MDA concentrations in preeclamptic women. Maternal plasma sFlt-1 levels showed a strong negative association with baby weight (n=37, r=-0.547, P=0.001), head circumference (n=37, r=-0.472, P=0.005) and baby chest circumference (n=37, r=-0.375, P=0.032) in the preeclamptic group. Cord plasma sFlt-1 concentrations were negatively associated with cord plasma DHA concentrations (n=28, r=-0.552, P=0.004). This study suggests that dysregulation of angiogenic factors may be associated with maternal oxidative stress. Increased oxidative stress may reduce cord DHA levels and increase sFlt-1 levels, leading to poor birth outcomes in preeclampsia.
Department of Nutritional Medicine, Interactive Research School for Health Affairs, Bharati Vidyapeeth University, Pune, India.
Asmita V
AV
Kulkarni
Savita S
SS
Mehendale
Hemlata R
HR
Yadav
Anitha S
AS
Kilari
Vaishali S
VS
Taralekar
Sadhana R
SR
Joshi
D000328:Adult; D043925:Angiogenesis Inducing Agents / Q000097:blood*; D001724:Birth Weight / Q000502:physiology; D004281:Docosahexaenoic Acids / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D006801:Humans; D007223:Infant; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D000072483:Placenta Growth Factor; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011257:Pregnancy Proteins / Q000097:blood; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood; D042442:Vascular Endothelial Growth Factors / Q000097:blood; D055815:Young Adult
D043925:Angiogenesis Inducing Agents; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D042442:Vascular Endothelial Growth Factors; D000072483:Placenta Growth Factor; D004281:Docosahexaenoic Acids; D008315:Malondialdehyde; D040281:Vascular Endothelial Growth Factor Receptor-1