Reduced uptake of the proliferation-seeking radiotracer technetium-99m-labelled pentavalent dimercaptosuccinic acid in a 47-year-old woman with severe breast epithelial hyperplasia taking ibuprofen: a case report.
BACKGROUND
Recent studies have reported a risk reduction in the progression of benign breast disease to breast carcinoma through COX-2 pathways.


METHODS
We present a case of severe epithelial hyperplasia in a 47-year-old woman with increased breast density submitted to scintimammography by the proliferation-imaging tracer Technetium-99m-labelled pentavalent dimercaptosuccinic acid, before and after an oral ibuprofen treatment for 4 weeks. The radiotracer uptake after ibuprofen intake was significantly reduced, both visually and by semi-quantitative analysis, based on a calculation of lesion-to-background ratios.


CONCLUSIONS
In proliferating breast lesions, scintigraphically displayed reduction in Technetium-99m-labelled pentavalent dimercaptosuccinic acid uptake may indicate inhibition by ibuprofen in the pathway of malignant epithelial cell transformation.
Department of Nuclear Medicine, Alexandra University Hospital, Vasilissis Sofias Avenue, Athens, 11528, Greece. vpapantoniou@gmail.com.
Vassilios J
VJ
Papantoniou
Evangelia K
EK
Sotiropoulou
Pipitsa N
PN
Valsamaki
Angeliki G
AG
Tsaroucha
Maria G
MG
Sotiropoulou
Nikolaos D
ND
Ptohis
Aikaterini J
AJ
Stipsanelli
Konstantinos E
KE
Dimitrakakis
Spyridon G
SG
Marinopoulos
Spyridon T
ST
Tsiouris
Aris J
AJ
Antsaklis