Involvement of bone marrow with intravascular large B-cell lymphoma.
Intravascular large B-cell lymphoma (IVLBCL) is a rare subtype of extranodal large B-cell lymphoma characterized by a selective proliferation of lymphoma cells within the lumina of vessels. We report a case of an 86-year-old man who presented with fever, shortness of breath and altered mental status. The diagnosis of IVLBCL was confirmed on a bone trephine biopsy that revealed positivity of CD20 and PAX5 immunohistochemical staining of lymphoma cells confined within the lumina of vessels. The patient had a rapidly deteriorating clinical course with a fatal outcome even before the specific treatment for the underlying disease was commenced.
Sajid
Raihan M
RM
Aga Khan University, Karachi, Sindh, Pakistan. raihan.sajid@aku.edu
Qureshi
Adnan
A
D000369:Aged, 80 and over; D018951:Antigens, CD20 / Q000032:analysis; D001853:Bone Marrow / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D051757:PAX5 Transcription Factor / Q000032:analysis; D019043:Vascular Neoplasms / Q000175:diagnosis / Q000473:pathology*
D018951:Antigens, CD20; D051757:PAX5 Transcription Factor; C497281:PAX5 protein, human