Research findings from nonpharmaceutical intervention studies for pandemic influenza and current gaps in the research.
In June 2006, the Centers for Disease Control and Prevention released a request for applications to identify, improve, and evaluate the effectiveness of nonpharmaceutical interventions (NPIs)-strategies other than vaccines and antiviral medications-to mitigate the spread of pandemic influenza within communities and across international borders (RFA-CI06-010). These studies have provided major contributions to seasonal and pandemic influenza knowledge. Nonetheless, key concerns were identified related to the acceptability and protective efficacy of NPIs. Large-scale intervention studies conducted over multiple influenza epidemics, as well as smaller studies in controlled laboratory settings, are needed to address the gaps in the research on transmission and mitigation of influenza in the community setting. The current novel influenza A (H1N1) pandemic underscores the importance of influenza research.
Aiello
Allison E
AE
Center for Social Epidemiology and Population Health, Department of Epidemiology, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, USA. aielloa@umich.edu
Coulborn
Rebecca M
RM
Aragon
Tomas J
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Baker
Michael G
MG
Burrus
Barri B
BB
Cowling
Benjamin J
BJ
Duncan
Alasdair
A
Enanoria
Wayne
W
Fabian
M Patricia
MP
Ferng
Yu-hui
YH
Larson
Elaine L
EL
Leung
Gabriel M
GM
Markel
Howard
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Milton
Donald K
DK
Monto
Arnold S
AS
Morse
Stephen S
SS
Navarro
J Alexander
JA
Park
Sarah Y
SY
Priest
Patricia
P
Stebbins
Samuel
S
Stern
Alexandra M
AM
Uddin
Monica
M
Wetterhall
Scott F
SF
Vukotich
Charles J
CJ
D004196:Disease Outbreaks / Q000517:prevention & control*; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D006801:Humans; D007251:Influenza, Human / Q000453:epidemiology* / Q000517:prevention & control* / Q000635:transmission