Combination of urinary kidney injury molecule-1 and interleukin-18 as early biomarker for the diagnosis and progressive assessment of acute kidney injury following cardiopulmonary bypass surgery: a prospective nested case-control study.
The aim of this nested case-control study was to assess the combined use of urinary kidney injury molecule (KIM)-1 and interleukin (IL)-18 for acute kidney injury (AKI) after cardiopulmonary bypass surgery (CPB). From a cohort of 122 subjects who underwent CPB, serial urinary KIM-1 and IL-18 concentrations were determined in 30 AKI and 92 non-AKI patients. An increased level of urinary KIM-1 was associated with the occurrence of AKI, whereas an increased level of IL-18 was related to progressive AKI. The combination of these two biomarkers facilitates the early diagnosis and assessment of the likely progression of AKI after CPB.
Liang
Xin-Ling
XL
Division of Nephrology, Guangdong General Hospital, Guangdong Academy of Medical Sciences, China.
Liu
Shuang-Xin
SX
Chen
Yuan-Han
YH
Yan
Li-Jun
LJ
Li
Heng
H
Xuan
Hui-Jie
HJ
Liang
Yong-Zheng
YZ
Shi
Wei
W
D000208:Acute Disease; D000328:Adult; D015415:Biomarkers / Q000652:urine; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D016022:Case-Control Studies; D018450:Disease Progression; D042241:Early Diagnosis; D000072596:Hepatitis A Virus Cellular Receptor 1; D006801:Humans; D020382:Interleukin-18 / Q000652:urine*; D007674:Kidney Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology; D008562:Membrane Glycoproteins / Q000652:urine*; D008875:Middle Aged; D011991:Receptors, Virus; D055815:Young Adult
D015415:Biomarkers; C491143:HAVCR1 protein, human; D000072596:Hepatitis A Virus Cellular Receptor 1; D020382:Interleukin-18; D008562:Membrane Glycoproteins; D011991:Receptors, Virus