The continuous flow synthesis of butane-2,3-diacetal protected building blocks using microreactors.
The continuous flow synthesis of butane-2,3-diacetal protected derivatives has been achieved using commercially available flow chemistry microreactors in concert with solid supported reagents and scavengers to provide in-line purification systems. The BDA protected products are all obtained in superior yield to the corresponding batch processes.
Carter
Catherine F
CF
Department of Chemistry, Innovative Technnology Centre, University of Cambridge, Lensfield Road, Cambridge, UK CB2 1EW.
Baxendale
Ian R
IR
Pavey
John B J
JB
Ley
Steven V
SV
D000080:Acetals / Q000138:chemical synthesis* / Q000737:chemistry; D002073:Butanes / Q000138:chemical synthesis* / Q000737:chemistry; D004867:Equipment Design; D008832:Microchemistry / Q000295:instrumentation* / Q000379:methods
D000080:Acetals; D002073:Butanes; C046888:butane