Box H/ACA small ribonucleoproteins.
Box H/ACA RNAs represent an abundant, evolutionarily conserved class of small noncoding RNAs. All H/ACA RNAs associate with a common set of proteins, and they function as ribonucleoprotein (RNP) enzymes mainly in the site-specific pseudouridylation of ribosomal RNAs (rRNAs) and small nuclear RNAs (snRNAs). Some H/ACA RNPs function in the nucleolytic processing of precursor rRNA (pre-rRNA) and synthesis of telomeric DNA. Thus, H/ACA RNPs are essential for three fundamental cellular processes: protein synthesis, mRNA splicing, and maintenance of genome integrity. Recently, great progress has been made toward understanding of the biogenesis, intracellular trafficking, structure, and function of H/ACA RNPs.
Kiss
Tamás
T
Laboratoire de Biologie Moléculaire Eucaryote du CNRS, UMR5099, IFR109 CNRS, Université Paul Sabatier, 118 Route de Narbonne, 31062 Toulouse Cedex 9, France. tamas@ibcg.biotoul.fr
Fayet-Lebaron
Eléonore
E
Jády
Beáta E
BE
D021581:Active Transport, Cell Nucleus; D000818:Animals; D019843:Archaeal Proteins / Q000378:metabolism; D020541:Coiled Bodies / Q000378:metabolism*; D019143:Evolution, Molecular; D042822:Genomic Instability; D006801:Humans; D019751:Intramolecular Transferases / Q000378:metabolism; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D014176:Protein Biosynthesis; D011487:Protein Conformation; D011560:Pseudouridine / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012326:RNA Splicing; D012333:RNA, Messenger / Q000378:metabolism; D012335:RNA, Ribosomal / Q000378:metabolism; D022661:RNA, Untranslated / Q000737:chemistry / Q000378:metabolism*; D017411:Ribonucleoproteins, Small Nuclear / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D019098:Telomerase / Q000378:metabolism
D019843:Archaeal Proteins; D012333:RNA, Messenger; D012335:RNA, Ribosomal; D022661:RNA, Untranslated; D017411:Ribonucleoproteins, Small Nuclear; D011560:Pseudouridine; D019098:Telomerase; D019751:Intramolecular Transferases; C096995:pseudouridine synthases