Regulation of angiogenesis by macrophages.
Abnormal angiogenesis is a cardinal feature in the pathophysiology of several diseases of the retina including retinopathy of prematurity, diabetic retinopathy and choroidal neovascularization associated with age-related macular degeneration. Recent evidence has implicated macrophages as components of the innate immune system that play a key role in regulating angiogenesis in the retina and choroid. This review will focus on the role of macrophages in regulating ocular angiogenesis.
Apte
Rajendra S
RS
Barnes Retina Institute, Washington University School of Medicine, St. Louis, MO 63110, USA. apte@vision.wustl.edu
D000818:Animals; D016764:Cell Polarity; D006801:Humans; D008264:Macrophages / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000473:pathology*