Antispasmodic and spasmolytic effects of methanolic extract from seeds of Garcinia kola on isolated rat small intestine.
The antispasmodic and spasmolytic effects of methanolic extract of seeds of Garcinia kola Heckel were studied on smooth muscle preparations in vitro. The influence of the extract on rat duodenum, jejunum and ileum was investigated using acetylcholine and barium chloride as agonists. The extract exhibited dose-dependent antispasmodic effects on contractions induced by acetylcholine, and dose-dependent spasmolytic effects on spasms induced by cumulatively increased concentrations of acetylcholine and barium chloride. The graded log concentration-response curves for acetylcholine were non-parallel but shifted to the right in the presence of the extract. It is concluded that the Garcinia kola extract inhibits smooth muscle activity via other mechanisms but not involving neither cholinergic nor adrenergic receptor interaction.
Department of Pharmacology, College of Medical Sciences, University of Calabar, Calabar, Nigeria.
P M
PM
Udia
V B
VB
Braide
D U
DU
Owu
D000109:Acetylcholine / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D017609:Barium Compounds / Q000494:pharmacology; D002712:Chlorides / Q000494:pharmacology; D018679:Cholinergic Agonists / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D029763:Garcinia kola; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012639:Seeds
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D017609:Barium Compounds; D002712:Chlorides; D018679:Cholinergic Agonists; D005765:Gastrointestinal Agents; D010276:Parasympatholytics; D010936:Plant Extracts; C024986:barium chloride; D011433:Propranolol; D000109:Acetylcholine; D011224:Prazosin