Hyperleptinemia positively correlated with metabolic syndrome in renal transplant recipients.
OBJECTIVE
Our aim was to evaluate the relationship between metabolic syndrome and fasting serum leptin concentration in renal transplant recipients.


METHODS
Fasting blood samples were obtained from 55 renal transplant recipients. Metabolic syndrome and its components were defined using the diagnostic criteria of the International Diabetes Federation.


RESULTS
Thirteen patients (23.6%) had metabolic syndrome. Fasting leptin concentrations were positively correlated with metabolic syndrome (p=0.003). Univariate linear regression analysis indicated fasting serum leptin values were positively correlated with waist circumference (r=0.284; p=0.036), body mass index (r=0.358; p=0.007), body fat mass (r=0.610; p<0.001), triglycerides (r=0.268; p=0.048), high-sensitivity C-reactive protein (hs-CRP) (r=0.377; p=0.005), triceps skinfold (r=0.335; p=0.012), and mid-arm fat area (r=0.351; p=0.009). Multivariate forward stepwise linear regression analysis of the significant variables revealed that body fat mass (R2 change=0.373; p<0.001) and hs-CRP (R2 change=0.045; p=0.049) were the independent predictors of fasting serum leptin concentration.


CONCLUSIONS
Serum leptin concentration correlates positively with metabolic syndrome in renal transplant recipients.
School of Medicine, Tzu Chi University Department of Surgical Oncology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan.
Ming-Che
MC
Lee
Chung-Jen
CJ
Lee
Guan-Jin
GJ
Ho
Chia-Chi
CC
Lee
Ming-Hui
MH
Shih
Kuei-Chun
KC
Chou
Bang-Gee
BG
Hsu
D000328:Adult; D015992:Body Mass Index; D005215:Fasting; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D020738:Leptin / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000209:etiology; D008875:Middle Aged; D016896:Treatment Outcome; D055105:Waist Circumference
D020738:Leptin