Physical compatibility of magnesium sulfate and sodium bicarbonate in a pharmacy-compounded hemofiltration solution.
OBJECTIVE
The physical compatibility of magnesium sulfate and sodium bicarbonate in a pharmacy-compounded hemofiltration solution was assessed.


METHODS
Two bicarbonate-buffered hemofiltration solutions (low- and high-magnesium formulations) were compounded in triplicate. The concentrations of magnesium (15 meq/L) and sodium bicarbonate (50 meq/L) in the high-magnesium formulation were chosen to be somewhat below the concentrations reported as being incompatible in a popular reference. The six hemofiltration bags were stored at 22-25 degrees C without protection from light for 48 hours. Physical compatibility was assessed by visual inspection and microscopy. The pH of the solutions was assayed 3-4 and 52-53 hours after compounding. Electrolyte and glucose concentrations of the solutions were assayed at 3-4 and 50-51 hours after preparation.


RESULTS
No particulate matter was observed by visual or microscopic inspection in the compounded hemofiltration solutions at 48 hours. The mean +/- S.D. pH values of the low-magnesium solutions were 8.01 +/- 0.02 and 8.04 +/- 0.02 at 3-4 and 52-53 hours after compounding, respectively. The mean +/- S.D. pH values of the high-magnesium solutions were 7.96 +/- 0.02 and 7.98 +/- 0.01 at 3-4 and 52-53 hours after compounding, respectively. The electrolyte and glucose concentrations in the low- and high-magnesium solutions were similar 3-4 and 50-51 hours after preparation.


CONCLUSIONS
Magnesium sulfate 1.5 meq/L and sodium bicarbonate 50 meq/L were physically compatible in a pharmacy-compounded hemofiltration solution for 48 hours when stored at 22-25 degrees C without protection from light.
Moriyama
Brad
B
Pharmacy Department, National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Henning
Stacey A
SA
Jin
Haksong
H
Kolf
Michael
M
Rehak
Nadja N
NN
Danner
Robert L
RL
Walsh
Thomas J
TJ
Grimes
George J
GJ
D015314:Dialysis Solutions / Q000737:chemistry*; D004339:Drug Compounding; D004344:Drug Incompatibility; D004356:Drug Storage; D004573:Electrolytes / Q000032:analysis; D005947:Glucose / Q000032:analysis; D006440:Hemofiltration; D006863:Hydrogen-Ion Concentration; D008278:Magnesium Sulfate / Q000737:chemistry*; D019999:Pharmaceutical Solutions; D010607:Pharmacy Service, Hospital; D017693:Sodium Bicarbonate / Q000737:chemistry*
D015314:Dialysis Solutions; D004573:Electrolytes; D019999:Pharmaceutical Solutions; D008278:Magnesium Sulfate; D017693:Sodium Bicarbonate; D005947:Glucose