Influences of thiopurine methyltransferase genotype and activity on thiopurine-induced leukopenia in Korean patients with inflammatory bowel disease: a retrospective cohort study.
Kim
Jae Hak
JH
Department of Internal Medicine, Dongguk University College of Medicine, Goyang-si, Korea.
Cheon
Jae Hee
JH
Hong
Seong Soo
SS
Eun
Chang Soo
CS
Byeon
Jeong-Sik
JS
Hong
Sung Yi
SY
Kim
Bo-Young
BY
Kwon
Soon-Ho
SH
Kim
Seung Won
SW
Han
Dong Soo
DS
Yang
Suk-Kyun
SK
Kim
Won Ho
WH
D000046:Academic Medical Centers; D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000493:pharmacokinetics; D044466:Asian People / Q000235:genetics*; D016009:Chi-Square Distribution; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005765:Gastrointestinal Agents / Q000009:adverse effects* / Q000493:pharmacokinetics; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy* / Q000201:enzymology / Q000208:ethnology / Q000235:genetics; D053208:Kaplan-Meier Estimate; D007970:Leukopenia / Q000139:chemically induced* / Q000208:ethnology / Q000235:genetics; D008297:Male; D015122:Mercaptopurine / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D008780:Methyltransferases / Q000235:genetics / Q000378:metabolism*; D010641:Phenotype; D016016:Proportional Hazards Models; D011755:Pyrophosphatases / Q000235:genetics / Q000378:metabolism; D056910:Republic of Korea; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D053719:Tandem Mass Spectrometry; D016896:Treatment Outcome; D055815:Young Adult; D000097630:Inosine Triphosphatase
D000893:Anti-Inflammatory Agents; D005765:Gastrointestinal Agents; D015122:Mercaptopurine; D008780:Methyltransferases; D011755:Pyrophosphatases; C488629:azathiopurine; C022745:thiopurine methyltransferase; C511829:ITPA protein, human; D000097630:Inosine Triphosphatase