title: Oxidative stress regulates left ventricular PDE5 expression in the failing heart.
authors.affiliation: Cardiovascular Division, University of Minnesota, Minneapolis, MN 55455, USA.
authors.forename: Zhongbing
authors.initials: Z
authors.lastname: Lu
authors.forename: Xin
authors.initials: X
authors.lastname: Xu
authors.forename: Xinli
authors.initials: X
authors.lastname: Hu
authors.forename: Sangjin
authors.initials: S
authors.lastname: Lee
authors.forename: Jay H
authors.initials: JH
authors.lastname: Traverse
authors.forename: Guangshuo
authors.initials: G
authors.lastname: Zhu
authors.forename: John
authors.initials: J
authors.lastname: Fassett
authors.forename: Yi
authors.initials: Y
authors.lastname: Tao
authors.forename: Ping
authors.initials: P
authors.lastname: Zhang
authors.forename: Cris
authors.initials: C
authors.lastname: dos Remedios
authors.forename: Marc
authors.initials: M
authors.lastname: Pritzker
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Hall
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Garry
authors.forename: Yingjie
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D017869:Cyclic GMP-Dependent Protein Kinases / Q000378:metabolism; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5 / Q000235:genetics / Q000378:metabolism*; D004195:Disease Models, Animal; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D006333:Heart Failure / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D032383:Myocytes, Cardiac / Q000201:enzymology*; D052247:Nitric Oxide Synthase Type II / Q000235:genetics / Q000378:metabolism; D009942:Organometallic Compounds / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D058986:Phosphodiesterase 5 Inhibitors; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D010766:Phosphorylation / Q000187:drug effects / Q000502:physiology; D010879:Piperazines / Q000494:pharmacology; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D011687:Purines / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism
chemical_list: D000975:Antioxidants; C426066:M40401; D009942:Organometallic Compounds; D058986:Phosphodiesterase 5 Inhibitors; D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; C499090:Sod3 protein, mouse; D013482:Superoxide Dismutase; D051057:Proto-Oncogene Proteins c-akt; D017869:Cyclic GMP-Dependent Protein Kinases; D048049:Extracellular Signal-Regulated MAP Kinases; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5; C517381:PDE5A protein, human; C517382:Pde5a protein, mouse