Eradication of the commensal intestinal microflora by oral antimicrobials interferes with the host response to lipopolysaccharide.
Umenai
T
T
Department of Anesthesiology and Intensive Care, University Hospital, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kamigyoku, Kyoto, 602-8566, Japan.
Hirai
H
H
Shime
N
N
Nakaya
T
T
Asahara
T
T
Nomoto
K
K
Kita
M
M
Tanaka
Y
Y
Imanishi
J
J
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D002439:Cefotaxime / Q000008:administration & dosage; D015536:Down-Regulation; D041981:Gastrointestinal Tract / Q000382:microbiology*; D015870:Gene Expression; D008070:Lipopolysaccharides / Q000276:immunology*; D016676:Macrophages, Alveolar / Q000276:immunology; D017737:Macrophages, Peritoneal / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013307:Streptomycin / Q000008:administration & dosage; D051195:Toll-Like Receptor 2 / Q000096:biosynthesis / Q000276:immunology; D051197:Toll-Like Receptor 4 / Q000096:biosynthesis / Q000276:immunology
D000890:Anti-Infective Agents; D008070:Lipopolysaccharides; C493486:Tlr2 protein, mouse; C493487:Tlr4 protein, mouse; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4; D002439:Cefotaxime; D013307:Streptomycin