Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells.
Pucer
Anja
A
Department of Genetic Toxicology and Cancer Biology, National Institute of Biology, Ljubljana, Slovenia. anja.pucer@nib.si <anja.pucer@nib.si>
Castino
Roberta
R
Mirković
Bojana
B
Falnoga
Ingrid
I
Slejkovec
Zdenka
Z
Isidoro
Ciro
C
Lah
Tamara T
TT
D000225:Adenine / Q000031:analogs & derivatives / Q000494:pharmacology; D000590:Amino Acid Chloromethyl Ketones / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000009:adverse effects / Q000627:therapeutic use*; D001343:Autophagy / Q000187:drug effects; D020169:Caspases / Q000378:metabolism; D002401:Cathepsin B / Q000037:antagonists & inhibitors / Q000502:physiology*; D056668:Cathepsin L / Q000037:antagonists & inhibitors / Q000502:physiology*; D045744:Cell Line, Tumor; D004151:Dipeptides / Q000494:pharmacology; D015536:Down-Regulation; D004852:Epoxy Compounds / Q000494:pharmacology; D005909:Glioblastoma / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D018942:Macrolides / Q000494:pharmacology; D010087:Oxides / Q000009:adverse effects / Q000627:therapeutic use*; D011725:Pyridines / Q000494:pharmacology
D000590:Amino Acid Chloromethyl Ketones; D000970:Antineoplastic Agents; D001152:Arsenicals; C400541:CA 074 methyl ester; C402823:CLIK 148; D004151:Dipeptides; D004852:Epoxy Compounds; D018942:Macrolides; D010087:Oxides; D011725:Pyridines; C096713:benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone; C025946:3-methyladenine; C040929:bafilomycin A1; D020169:Caspases; C533912:CTSB protein, human; D002401:Cathepsin B; C534281:CTSL protein, human; D056668:Cathepsin L; D000225:Adenine; D000077237:Arsenic Trioxide