Glucose prevents the fall in ventromedial hypothalamic GABA that is required for full activation of glucose counterregulatory responses during hypoglycemia.
Zhu
Wanling
W
Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar St., New Haven, CT, USA.
Czyzyk
Daniel
D
Paranjape
Sachin A
SA
Zhou
Ligang
L
Horblitt
Adam
A
Szabó
Gábor
G
Seashore
Margretta R
MR
Sherwin
Robert S
RS
Chan
Owen
O
D000704:Analysis of Variance; D000818:Animals; D001640:Bicuculline / Q000008:administration & dosage; D001786:Blood Glucose / Q000378:metabolism; D002408:Catheters, Indwelling; D003981:Diazoxide / Q000008:administration & dosage; D004837:Epinephrine / Q000097:blood; D018756:GABA Antagonists / Q000008:administration & dosage; D005947:Glucose / Q000008:administration & dosage* / Q000378:metabolism; D015309:Glucose Clamp Technique; D006706:Homeostasis / Q000502:physiology; D007003:Hypoglycemia / Q000378:metabolism*; D007328:Insulin / Q000097:blood; D008297:Male; D017551:Microdialysis; D008845:Microinjections; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D024661:Potassium Channels, Inwardly Rectifying / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000378:metabolism; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D001786:Blood Glucose; D018756:GABA Antagonists; D007328:Insulin; D024661:Potassium Channels, Inwardly Rectifying; D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D005947:Glucose; D003981:Diazoxide; D001640:Bicuculline; D004837:Epinephrine