A novel Rac-dependent checkpoint in B cell development controls entry into the splenic white pulp and cell survival.
Henderson
Robert B
RB
Division of Immune Cell Biology, Medical Research Council National Institute for Medical Research, London NW7 1AA, England, UK.
Grys
Katarzyna
K
Vehlow
Anne
A
de Bettignies
Carine
C
Zachacz
Agnieszka
A
Henley
Tom
T
Turner
Martin
M
Batista
Facundo
F
Tybulewicz
Victor L J
VL
D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000494:pharmacology; D015703:Antigens, CD / Q000378:metabolism; D016175:B-Lymphocyte Subsets / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology / Q000378:metabolism*; D001854:Bone Marrow Cells / Q000166:cytology / Q000276:immunology; D002448:Cell Adhesion / Q000235:genetics / Q000276:immunology; D002454:Cell Differentiation / Q000187:drug effects / Q000276:immunology; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation; D002470:Cell Survival / Q000235:genetics; D018925:Chemokines / Q000494:pharmacology; D007072:Immunoglobulin D / Q000378:metabolism; D016023:Integrins / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics; D016169:Lymphocyte Function-Associated Antigen-1 / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D009479:Neuropeptides / Q000235:genetics; D037342:Pertussis Toxin / Q000494:pharmacology; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D051567:Proto-Oncogene Proteins c-vav / Q000235:genetics; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology; D013154:Spleen / Q000166:cytology* / Q000276:immunology; D000072377:Syk Kinase; D051020:bcl-X Protein / Q000235:genetics; D020744:rac GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D020830:rac1 GTP-Binding Protein; D020827:rap1 GTP-Binding Proteins / Q000378:metabolism; D000097766:RAC2 GTP-Binding Protein
D000906:Antibodies; D015703:Antigens, CD; D018925:Chemokines; D007072:Immunoglobulin D; D016023:Integrins; D047908:Intracellular Signaling Peptides and Proteins; D016169:Lymphocyte Function-Associated Antigen-1; D009479:Neuropeptides; D037342:Pertussis Toxin; D011505:Protein-Tyrosine Kinases; D051567:Proto-Oncogene Proteins c-vav; D019718:Receptors, CXCR4; D019707:Receptors, Chemokine; D000072377:Syk Kinase; D051020:bcl-X Protein; D020744:rac GTP-Binding Proteins; D020830:rac1 GTP-Binding Protein; D020827:rap1 GTP-Binding Proteins; D000097766:RAC2 GTP-Binding Protein; C494812:Bcl2l1 protein, mouse; C514936:CXCR4 protein, mouse; C484602:Rac1 protein, mouse; C000606897:Syk protein, mouse