title: Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella.
authors.affiliation: Institute for Molecular Bioscience and ARC Centre of Excellence in Bioinformatics, The University of Queensland, St Lucia, Queensland, Australia.
authors.forename: Markus C
authors.initials: MC
authors.lastname: Kerr
authors.forename: Jack T H
authors.initials: JT
authors.lastname: Wang
authors.forename: Natalie A
authors.initials: NA
authors.lastname: Castro
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Hamilton
authors.forename: Liam
authors.initials: L
authors.lastname: Town
authors.forename: Darren L
authors.initials: DL
authors.lastname: Brown
authors.forename: Frederic A
authors.initials: FA
authors.lastname: Meunier
authors.forename: Nat F
authors.initials: NF
authors.lastname: Brown
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Stow
authors.forename: Rohan D
authors.initials: RD
authors.lastname: Teasdale
mesh_terms: D000631:Aminopyridines / Q000494:pharmacology; D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D002460:Cell Line; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism; D006575:Heterocyclic Compounds, 3-Ring / Q000494:pharmacology; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008264:Macrophages / Q000382:microbiology; D008565:Membrane Proteins / Q000378:metabolism; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010873:Pinocytosis; D034622:RNA Interference; D012486:Salmonella typhimurium / Q000254:growth & development / Q000472:pathogenicity*; D014617:Vacuoles / Q000378:metabolism; D020691:rab GTP-Binding Proteins / Q000378:metabolism; D000090802:rab7 GTP-Binding Proteins
chemical_list: D000631:Aminopyridines; D001426:Bacterial Proteins; D006575:Heterocyclic Compounds, 3-Ring; D008565:Membrane Proteins; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D020691:rab GTP-Binding Proteins; D000090802:rab7 GTP-Binding Proteins; C540576:6-amino-N-(3-(4-(4-morpholinyl)pyrido(3',2'-4,5)furo(3,2-d)pyrimidin-2-yl)phenyl)-3-pyridinecarboxamide; C440638:SPI-2 protein, Salmonella; C000716463:rab7 GTP-binding proteins, human