Natural therapeutic magnesium lithospermate B potently protects the endothelium from hyperglycaemia-induced dysfunction.
Kim
So Hun
SH
Division of Endocrinology and Metabolism, Department of Internal Medicine, Inha University School of Medicine, Incheon, Republic of Korea.
Kim
Soo Hyun
SH
Choi
Minah
M
Lee
Yongho
Y
Kim
Young Ook
YO
Ahn
Duck Sun
DS
Kim
Young Ho
YH
Kang
Eun Seok
ES
Lee
Eun Jig
EJ
Jung
Mankil
M
Cho
Jin Won
JW
Williams
Darren R
DR
Lee
Hyun Chul
HC
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D005947:Glucose / Q000378:metabolism*; D017127:Glycation End Products, Advanced / Q000097:blood; D006031:Glycosylation; D051547:Heme Oxygenase-1 / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000187:drug effects; D051267:NF-E2-Related Factor 2 / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D009573:Nitrites / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D051381:Rats; D020334:Rats, Inbred OLETF; D020318:Rats, Long-Evans; D017382:Reactive Oxygen Species / Q000378:metabolism; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects*
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D017127:Glycation End Products, Advanced; D051267:NF-E2-Related Factor 2; C495635:NFE2L2 protein, human; D009573:Nitrites; D017382:Reactive Oxygen Species; C061091:lithospermate B; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat; C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D005947:Glucose