Cystatin B inhibition of TRAIL-induced apoptosis is associated with the protection of FLIP(L) from degradation by the E3 ligase itch in human melanoma cells.
Yang
F
F
Immunology and Oncology Unit, Calvary Mater Newcastle Hospital, Newcastle, NSW 2300, Australia.
Tay
K H
KH
Dong
L
L
Thorne
R F
RF
Jiang
C C
CC
Yang
E
E
Tseng
H-Y
HY
Liu
H
H
Christopherson
R
R
Hersey
P
P
Zhang
X D
XD
D017209:Apoptosis; D053446:CASP8 and FADD-Like Apoptosis Regulating Protein / Q000378:metabolism*; D053181:Caspase 8 / Q000378:metabolism; D045744:Cell Line, Tumor; D055313:Cystatin B / Q000235:genetics / Q000378:metabolism*; D055785:Gene Knockdown Techniques; D006801:Humans; D008545:Melanoma / Q000201:enzymology / Q000378:metabolism*; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000494:pharmacology*; D044767:Ubiquitin-Protein Ligases / Q000378:metabolism*
D053446:CASP8 and FADD-Like Apoptosis Regulating Protein; D034741:RNA, Small Interfering; D012097:Repressor Proteins; D053221:TNF-Related Apoptosis-Inducing Ligand; D055313:Cystatin B; C432966:ITCH protein, human; D044767:Ubiquitin-Protein Ligases; D053181:Caspase 8