1,7-Disubstituted oxyindoles are potent and selective EP(3) receptor antagonists.
Zhou
Nian
N
deCODE Chemistry, Woodridge, IL 60517, USA.
Polozov
Alexandre M
AM
O'Connell
Matthew
M
Burgeson
James
J
Yu
Peng
P
Zeller
Wayne
W
Zhang
Jun
J
Onua
Emmanuel
E
Ramirez
Jose
J
Palsdottir
Gudrun A
GA
Halldorsdottir
Gudrun V
GV
Andresson
Thorkell
T
Kiselyov
Alex S
AS
Gurney
Mark
M
Singh
Jasbir
J
D000818:Animals; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D018078:Receptors, Prostaglandin E / Q000037:antagonists & inhibitors*; D058308:Receptors, Prostaglandin E, EP3 Subtype
D007211:Indoles; D010975:Platelet Aggregation Inhibitors; C545649:Ptger3 protein, rat; D018078:Receptors, Prostaglandin E; D058308:Receptors, Prostaglandin E, EP3 Subtype