title: Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors.
authors.affiliation: Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong-dong, Gwangju 500-712, Republic of Korea.
authors.forename: Soo-Jeong
authors.initials: SJ
authors.lastname: Choi
authors.forename: Joong-Heui
authors.initials: JH
authors.lastname: Cho
authors.forename: Isak
authors.initials: I
authors.lastname: Im
authors.forename: So-Deok
authors.initials: SD
authors.lastname: Lee
authors.forename: Ji-Yeon
authors.initials: JY
authors.lastname: Jang
authors.forename: Yu-Min
authors.initials: YM
authors.lastname: Oh
authors.forename: Yong-Keun
authors.initials: YK
authors.lastname: Jung
authors.forename: Eun-Seok
authors.initials: ES
authors.lastname: Jeon
authors.forename: Yong-Chul
authors.initials: YC
authors.lastname: Kim
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D002460:Cell Line; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D015195:Drug Design; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D008968:Molecular Conformation
chemical_list: D004095:Dihydropyridines; C038806:1,4-dihydropyridine; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human