Novel benzofuran-3-one indole inhibitors of PI3 kinase-alpha and the mammalian target of rapamycin: hit to lead studies.
Bursavich
Matthew G
MG
Medicinal Chemistry, Chemical Sciences, Wyeth Research, Pearl River, NY 10965, USA.
Brooijmans
Natasja
N
Feldberg
Lawrence
L
Hollander
Irwin
I
Kim
Stephen
S
Lombardi
Sabrina
S
Park
Kaapjoo
K
Mallon
Robert
R
Gilbert
Adam M
AM
D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors*; D008958:Models, Molecular; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D058570:TOR Serine-Threonine Kinases
D001572:Benzofurans; D047908:Intracellular Signaling Peptides and Proteins; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors; C546842:MTOR protein, human; D017346:Protein Serine-Threonine Kinases; D058570:TOR Serine-Threonine Kinases