Recombinant apolipoprotein A-I Milano rapidly reverses aortic valve stenosis and decreases leaflet inflammation in an experimental rabbit model.
Speidl
Walter S
WS
Atherothrombosis Research Unit, Mount Sinai School of Medicine New York, NY, USA.
Cimmino
Giovanni
G
Ibanez
Borja
B
Elmariah
Sammy
S
Hutter
Randolph
R
Garcia
Mario J
MJ
Fuster
Valentin
V
Goldman
Martin E
ME
Badimon
Juan J
JJ
D000469:Alkaline Phosphatase / Q000187:drug effects; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001024:Aortic Valve Stenosis / Q000188:drug therapy* / Q000473:pathology; D016632:Apolipoprotein A-I / Q000627:therapeutic use*; D002114:Calcinosis / Q000473:pathology; D058628:Myofibroblasts / Q000473:pathology; D058226:Plaque, Atherosclerotic / Q000473:pathology; D011817:Rabbits; D011897:Random Allocation; D011994:Recombinant Proteins / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D016632:Apolipoprotein A-I; D011994:Recombinant Proteins; C080631:apolipoprotein A-I Milano; D000469:Alkaline Phosphatase