title: HMBA depolymerizes microtubules, activates mitotic checkpoints and induces mitotic block in MCF-7 cells by binding at the colchicine site in tubulin.
authors.affiliation: Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
authors.forename: Biswa Prasun
authors.initials: BP
authors.lastname: Chatterji
authors.forename: Mithu
authors.initials: M
authors.lastname: Banerjee
authors.forename: Parminder
authors.initials: P
authors.lastname: Singh
authors.forename: Dulal
authors.initials: D
authors.lastname: Panda
mesh_terms: D000081:Acetamides / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites; D001943:Breast Neoplasms / Q000473:pathology; D045744:Cell Line, Tumor; D003078:Colchicine / Q000378:metabolism; D005260:Female; D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D008938:Mitosis / Q000187:drug effects*; D015394:Molecular Structure; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism*
chemical_list: D000081:Acetamides; D000970:Antineoplastic Agents; D014404:Tubulin; C014026:hexamethylene bisacetamide; D003078:Colchicine