title: Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation.
authors.affiliation: Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
authors.forename: Andrew
authors.initials: A
authors.lastname: Oberst
authors.forename: Cristina
authors.initials: C
authors.lastname: Pop
authors.forename: Alexandre G
authors.initials: AG
authors.lastname: Tremblay
authors.forename: Véronique
authors.initials: V
authors.lastname: Blais
authors.forename: Jean-Bernard
authors.initials: JB
authors.lastname: Denault
authors.forename: Guy S
authors.initials: GS
authors.lastname: Salvesen
authors.forename: Douglas R
authors.initials: DR
authors.lastname: Green
mesh_terms: D017209:Apoptosis; D001665:Binding Sites; D053181:Caspase 8 / Q000378:metabolism*; D020169:Caspases / Q000378:metabolism; D020134:Catalytic Domain; D002460:Cell Line; D019281:Dimerization; D010450:Endopeptidases / Q000378:metabolism; D004789:Enzyme Activation; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D008954:Models, Biological; D009154:Mutation; D017434:Protein Structure, Tertiary
chemical_list: D010450:Endopeptidases; C099488:TEV protease; D053181:Caspase 8; D020169:Caspases