title: Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).
authors.affiliation: Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via Pietro Giuria 9, 10125 Torino, Italy.
authors.forename: Marco L
authors.initials: ML
authors.lastname: Lolli
authors.forename: Barbara
authors.initials: B
authors.lastname: Rolando
authors.forename: Paolo
authors.initials: P
authors.lastname: Tosco
authors.forename: Shilpi
authors.initials: S
authors.lastname: Chaurasia
authors.forename: Antonella
authors.initials: A
authors.lastname: Di Stilo
authors.forename: Loretta
authors.initials: L
authors.lastname: Lazzarato
authors.forename: Eva
authors.initials: E
authors.lastname: Gorassini
authors.forename: Riccardo
authors.initials: R
authors.lastname: Ferracini
authors.forename: Simonetta
authors.initials: S
authors.lastname: Oliaro-Bosso
authors.forename: Roberta
authors.initials: R
authors.lastname: Fruttero
authors.forename: Alberto
authors.initials: A
authors.lastname: Gasco
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured; D002846:Chromatography, Affinity; D004164:Diphosphonates / Q000138:chemical synthesis* / Q000494:pharmacology*; D017886:Durapatite / Q000737:chemistry; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors; D006801:Humans; D000077557:Ibandronic Acid; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D008958:Models, Molecular; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D020030:Nitric Oxide Donors / Q000138:chemical synthesis / Q000494:pharmacology; D009584:Nitrogen / Q000737:chemistry*; D010012:Osteogenesis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D020030:Nitric Oxide Donors; D014665:Vasodilator Agents; D017886:Durapatite; D013186:Farnesyl-Diphosphate Farnesyltransferase; D009584:Nitrogen; D000077557:Ibandronic Acid