Rescue of cystathionine beta-synthase (CBS) mutants with chemical chaperones: purification and characterization of eight CBS mutant enzymes.
Majtan
Tomas
T
Department of Pediatrics and the Colorado Intellectual and Developmental Disabilities Research Center, School of Medicine, University of Colorado at Denver, Aurora, Colorado 80045, USA.
Liu
Lu
L
Carpenter
John F
JF
Kraus
Jan P
JP
D003541:Cystathionine beta-Synthase / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D004795:Enzyme Stability / Q000187:drug effects / Q000235:genetics; D004926:Escherichia coli / Q000737:chemistry; D029968:Escherichia coli Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D050956:HSP40 Heat-Shock Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D006712:Homocystinuria / Q000188:drug therapy / Q000201:enzymology / Q000235:genetics; D006801:Humans; D020125:Mutation, Missense; D011736:Pyridoxine / Q000494:pharmacology / Q000627:therapeutic use; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D014803:Vitamin B Complex / Q000494:pharmacology / Q000627:therapeutic use
C494635:DnaJ protein, E coli; D029968:Escherichia coli Proteins; D050956:HSP40 Heat-Shock Proteins; D011994:Recombinant Proteins; D014803:Vitamin B Complex; D003541:Cystathionine beta-Synthase; D011736:Pyridoxine