Ethyl pyruvate has a neuroprotective effect through activation of extracellular signal-regulated kinase in Parkinson's disease model.
Choi
Jae-Sun
JS
Department of Anatomy and Neurobiology, Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul 130-701, Republic of Korea.
Lee
Mi Suk
MS
Jeong
Joo-Won
JW
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002460:Cell Line; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism; D015259:Dopamine Agents / Q000494:pharmacology; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism*; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D010300:Parkinson Disease / Q000201:enzymology / Q000517:prevention & control*; D011773:Pyruvates / Q000494:pharmacology*; D013378:Substantia Nigra / Q000187:drug effects / Q000201:enzymology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015259:Dopamine Agents; D018696:Neuroprotective Agents; D011773:Pyruvates; C046522:ethyl pyruvate; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D048049:Extracellular Signal-Regulated MAP Kinases; D004298:Dopamine