Resveratrol attenuates hyperglycemia-mediated oxidative stress, proinflammatory cytokines and protects hepatocytes ultrastructure in streptozotocin-nicotinamide-induced experimental diabetic rats.
Palsamy
P
P
Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600025, Tamilnadu, India. ppalsamy@gmail.com
Sivakumar
S
S
Subramanian
S
S
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D016207:Cytokines / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D005907:Gliclazide / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects* / Q000648:ultrastructure; D006943:Hyperglycemia / Q000188:drug therapy / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D046529:Microscopy, Electron, Transmission; D008954:Models, Biological; D009536:Niacinamide / Q000633:toxicity; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
D000975:Antioxidants; D016207:Cytokines; D007004:Hypoglycemic Agents; D018836:Inflammation Mediators; D013267:Stilbenes; D009536:Niacinamide; D005907:Gliclazide; D000077185:Resveratrol