Cr(VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells.
Son
Young-Ok
YO
Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536-0305, USA.
Hitron
J Andrew
JA
Wang
Xin
X
Chang
Qingshan
Q
Pan
Jingju
J
Zhang
Zhuo
Z
Liu
Jiankang
J
Wang
Shuxia
S
Lee
Jeong-Chae
JC
Shi
Xianglin
X
D000818:Animals; D017209:Apoptosis; D002274:Carcinogens, Environmental / Q000633:toxicity*; D020169:Caspases / Q000096:biosynthesis*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002857:Chromium / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
D002274:Carcinogens, Environmental; D017382:Reactive Oxygen Species; D016159:Tumor Suppressor Protein p53; D002857:Chromium; C074702:chromium hexavalent ion; D020169:Caspases