Ayanin, a non-selective phosphodiesterase 1-4 inhibitor, effectively suppresses ovalbumin-induced airway hyperresponsiveness without affecting xylazine/ketamine-induced anesthesia.
Lee
Fei-Peng
FP
Department of Otolaryngology, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
Shih
Chwen-Ming
CM
Shen
Hsin-Yi
HY
Chen
Chien-Ming
CM
Chen
Chi-Ming
CM
Ko
Wun-Chang
WC
D000758:Anesthesia; D000818:Animals; D001249:Asthma / Q000188:drug therapy; D001992:Bronchoalveolar Lavage Fluid; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D006967:Hypersensitivity / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D007073:Immunoglobulin E / Q000097:blood / Q000378:metabolism; D007074:Immunoglobulin G / Q000097:blood / Q000378:metabolism; D007249:Inflammation / Q000473:pathology; D007649:Ketamine / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000494:pharmacology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D012137:Respiratory System / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D014991:Xylazine / Q000494:pharmacology*
D016207:Cytokines; D005419:Flavonoids; D007074:Immunoglobulin G; D010726:Phosphodiesterase Inhibitors; C459623:ayanin; D014991:Xylazine; D007073:Immunoglobulin E; D007649:Ketamine; D010047:Ovalbumin; D010727:Phosphoric Diester Hydrolases