Resveratrol induces DNA double-strand breaks through human topoisomerase II interaction.
Leone
Stefano
S
Dipartimento di Biologia, Università degli Studi Roma Tre, Roma, Italy.
Cornetta
Tommaso
T
Basso
Emiliano
E
Cozzi
Renata
R
D000951:Antigens, Neoplasm; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000188:drug therapy; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D053903:DNA Breaks, Double-Stranded / Q000187:drug effects*; D004250:DNA Topoisomerases, Type II; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D005910:Glioma / Q000188:drug therapy; D006657:Histones / Q000378:metabolism; D006801:Humans; D010766:Phosphorylation; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D059005:Topoisomerase II Inhibitors
D000951:Antigens, Neoplasm; D000972:Antineoplastic Agents, Phytogenic; D004268:DNA-Binding Proteins; C468783:H2AX protein, human; D006657:Histones; D013267:Stilbenes; D059005:Topoisomerase II Inhibitors; D004250:DNA Topoisomerases, Type II; D000077185:Resveratrol