Structure-activity relationships in toll-like receptor-2 agonistic diacylthioglycerol lipopeptides.
Wu
Wenyan
W
Department of Medicinal Chemistry, University of Kansas, 2030 Becker Drive, Lawrence, Kansas 66047, USA.
Li
Rongti
R
Malladi
Subbalakshmi S
SS
Warshakoon
Hemamali J
HJ
Kimbrell
Matthew R
MR
Amolins
Michael W
MW
Ukani
Rehman
R
Datta
Apurba
A
David
Sunil A
SA
D002460:Cell Line; D003553:Cystine / Q000737:chemistry; D005990:Glycerol / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D055666:Lipopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D016328:NF-kappa B / Q000096:biosynthesis; D012694:Serine / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013440:Sulfides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051195:Toll-Like Receptor 2 / Q000819:agonists*
D055666:Lipopeptides; D016328:NF-kappa B; D013440:Sulfides; C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2; D012694:Serine; D003553:Cystine; C009465:thioglycerol; D005990:Glycerol