Alkylation of sperm DNA is associated with male factor infertility and a reduction in the proportion of oocytes fertilised during assisted reproduction.
Stocks
S J
SJ
Centre for Occupational and Environmental Health, School of Community-Based Medicine, Faculty of Medical and Human Sciences, University of Manchester, Oxford Rd, Manchester M13 9PL, UK. jillstocks@manchester.ac.uk
Agius
R M
RM
Cooley
N
N
Harrison
K L
KL
Brison
D R
DR
Horne
G
G
Gibbs
A
A
Povey
A C
AC
D000328:Adult; D000477:Alkylating Agents / Q000032:analysis; D018736:DNA Adducts / Q000032:analysis; D019175:DNA Methylation; D003849:Deoxyguanosine / Q000031:analogs & derivatives; D005260:Female; D006147:Guanine / Q000031:analogs & derivatives / Q000032:analysis; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D027724:Reproductive Techniques, Assisted; D013094:Spermatozoa / Q000648:ultrastructure*
D000477:Alkylating Agents; D018736:DNA Adducts; C048746:7-methyl-2-deoxyguanosine; D006147:Guanine; C008450:7-methylguanine; D003849:Deoxyguanosine