title: Investigation into UDP-glucuronosyltransferase (UGT) enzyme kinetics of imidazole- and triazole-containing antifungal drugs in human liver microsomes and recombinant UGT enzymes.
authors.affiliation: Pfizer Global R&D, Ramsgate Rd., Sandwich, Kent CT13 9NJ, UK. karine.bourcier@pfizer.com
authors.forename: Karine
authors.initials: K
authors.lastname: Bourcier
authors.forename: Ruth
authors.initials: R
authors.lastname: Hyland
authors.forename: Sarah
authors.initials: S
authors.lastname: Kempshall
authors.forename: Russell
authors.initials: R
authors.lastname: Jones
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Maximilien
authors.forename: Nicola
authors.initials: N
authors.lastname: Irvine
authors.forename: Barry
authors.initials: B
authors.lastname: Jones
mesh_terms: D000935:Antifungal Agents / Q000378:metabolism / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D020719:Glucuronides / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000276:immunology / Q000493:pharmacokinetics*; D008862:Microsomes, Liver / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity; D014230:Triazoles / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D020719:Glucuronides; D007093:Imidazoles; D014230:Triazoles; C038008:croconazole; D014453:Glucuronosyltransferase; C020527:tioconazole