Expression of Toll-like receptor 3 and Toll-like receptor 7 in muscle is characteristic of inflammatory myopathy and is differentially regulated by Th1 and Th17 cytokines.
Tournadre
A
A
University of Lyon, Edouard Herriot Hospital, Lyon, France.
Lenief
V
V
Miossec
P
P
D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism / Q000494:pharmacology*; D003882:Dermatomyositis / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology; D020381:Interleukin-17 / Q000494:pharmacology; D018485:Muscle Fibers, Skeletal / Q000187:drug effects / Q000378:metabolism; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D006377:T-Lymphocytes, Helper-Inducer / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051196:Toll-Like Receptor 3 / Q000235:genetics / Q000378:metabolism*; D051199:Toll-Like Receptor 7 / Q000235:genetics / Q000378:metabolism*
D016207:Cytokines; C508717:IL17A protein, human; D020381:Interleukin-17; C495344:TLR3 protein, human; C495348:TLR7 protein, human; D051196:Toll-Like Receptor 3; D051199:Toll-Like Receptor 7; D007371:Interferon-gamma