Development of a fluorescence-based assay for drug interactions with human Multidrug Resistance Related Protein (MRP2; ABCC2) in MDCKII-MRP2 membrane vesicles.
Lechner
Christian
C
Institute of Pharmacy and Molecular Biotechnology, Ruprecht-Karls-University, Heidelberg, Germany.
Reichel
Valeska
V
Moenning
Ursula
U
Reichel
Andreas
A
Fricker
Gert
G
D015720:5'-Nucleotidase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D015153:Blotting, Western; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005452:Fluoresceins / Q000008:administration & dosage / Q000494:pharmacology*; D005456:Fluorescent Dyes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D008854:Microscopy, Electron / Q000379:methods*; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000378:metabolism*; D013997:Time Factors
D015720:5'-Nucleotidase; D000469:Alkaline Phosphatase; D005452:Fluoresceins; D005456:Fluorescent Dyes; D000089762:Multidrug Resistance-Associated Protein 2; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C000715087:ABCC2 protein, human; C053897:5(6)-carboxy-2',7'-dichlorofluorescein