title: Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate.
authors.affiliation: Department of Physiology and the Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. buckirob@mail.med.upenn.edu
authors.forename: Robert
authors.initials: R
authors.lastname: Bucki
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Leszczynska
authors.forename: Fitzroy J
authors.initials: FJ
authors.lastname: Byfield
authors.forename: David E
authors.initials: DE
authors.lastname: Fein
authors.forename: Esther
authors.initials: E
authors.lastname: Won
authors.forename: Katrina
authors.initials: K
authors.lastname: Cruz
authors.forename: Andrzej
authors.initials: A
authors.lastname: Namiot
authors.forename: Alina
authors.initials: A
authors.lastname: Kulakowska
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Namiot
authors.forename: Paul B
authors.initials: PB
authors.lastname: Savage
authors.forename: Scott L
authors.initials: SL
authors.lastname: Diamond
authors.forename: Paul A
authors.initials: PA
authors.lastname: Janmey
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides; D001424:Bacterial Infections / Q000188:drug therapy; D018441:Biofilms / Q000187:drug effects; D054804:Cathelicidins / Q000737:chemistry / Q000494:pharmacology; D002417:Cattle; D002478:Cells, Cultured; D003907:Dexamethasone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D066298:In Vitro Techniques; D007378:Interleukins / Q000096:biosynthesis; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D008826:Microbial Sensitivity Tests; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011965:Receptors, Glucocorticoid / Q000187:drug effects; D013096:Spermine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D023181:Antimicrobial Cationic Peptides; D054804:Cathelicidins; D007378:Interleukins; D011965:Receptors, Glucocorticoid; D013096:Spermine; D003907:Dexamethasone