title: RasGRP1 is essential for ras activation by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate in epidermal keratinocytes.
authors.affiliation: Cancer Research Center of Hawaii, University of Hawaii at Manoa, Honolulu, Hawaii 96813, USA.
authors.forename: Amrish
authors.initials: A
authors.lastname: Sharma
authors.forename: Courtney T
authors.initials: CT
authors.lastname: Luke
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Dower
authors.forename: James C
authors.initials: JC
authors.lastname: Stone
authors.forename: Patricia S
authors.initials: PS
authors.lastname: Lorenzo
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002460:Cell Line; D004789:Enzyme Activation / Q000187:drug effects / Q000235:genetics; D004817:Epidermis / Q000378:metabolism*; D048049:Extracellular Signal-Regulated MAP Kinases / Q000235:genetics / Q000378:metabolism; D020868:Gene Silencing; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics / Q000378:metabolism*; D015603:Keratinocytes / Q000378:metabolism*; D048670:MAP Kinase Kinase 4 / Q000235:genetics / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D002273:Carcinogens; D020662:Guanine Nucleotide Exchange Factors; C112278:Rasgrp1 protein, mouse; D048049:Extracellular Signal-Regulated MAP Kinases; D048670:MAP Kinase Kinase 4; C495971:Hras protein, mouse; D016283:Proto-Oncogene Proteins p21(ras); D013755:Tetradecanoylphorbol Acetate