Olfactory discrimination training up-regulates and reorganizes expression of microRNAs in adult mouse hippocampus.
Smalheiser
Neil R
NR
Department of Psychiatry and UIC Psychiatric Institute MC912, University of Illinois at Chicago, 1601 W. Taylor Street, Chicago, IL 60612, USA. neils@uic.edu
Lugli
Giovanni
G
Lenon
Angela L
AL
Davis
John M
JM
Torvik
Vetle I
VI
Larson
John
J
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D004192:Discrimination, Psychological / Q000502:physiology*; D006624:Hippocampus / Q000502:physiology*; D007858:Learning / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D011897:Random Allocation; D012903:Smell / Q000502:physiology*; D015854:Up-Regulation
D035683:MicroRNAs
BDNF, brain-derived neurotrophic factor; Ct, threshold cycle value; DHPG, (S)-3,5-dihydroxyphenylglycine; LTP, long-term potentiation; MEF2, myocyte enhancer factor-2; NMDA, N-methyl-d-aspartate; RISC, RNA-induced silencing complex; RT-PCR, reverse transcription-PCR; TLDA, TaqMan® Low Density Arrays; TOP, terminal oligopyrimidine; dicer; learning; miRNA, microRNA; microRNA; olfactory discrimination; pre-miR, miRNA small hairpin precursor; pri-miR, primary miRNA gene transcript; snoRNA, small nucleolar RNA; synaptic plasticity