Inhibition of Lck enhances glucocorticoid sensitivity and apoptosis in lymphoid cell lines and in chronic lymphocytic leukemia.
Harr
M W
MW
Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-7285, USA.
Caimi
P F
PF
McColl
K S
KS
Zhong
F
F
Patel
S N
SN
Barr
P M
PM
Distelhorst
C W
CW
D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000276:immunology; D001402:B-Lymphocytes / Q000378:metabolism; D020013:Calcium Signaling / Q000187:drug effects / Q000276:immunology; D045744:Cell Line, Tumor; D002478:Cells, Cultured; D000069439:Dasatinib; D003907:Dexamethasone / Q000494:pharmacology; D015536:Down-Regulation / Q000235:genetics; D019008:Drug Resistance, Neoplasm / Q000187:drug effects*; D004357:Drug Synergism; D020869:Gene Expression Profiling; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology*; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D010766:Phosphorylation / Q000187:drug effects; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D034741:RNA, Small Interfering / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000819:agonists; D015398:Signal Transduction / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D013844:Thiazoles / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D005938:Glucocorticoids; D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D034741:RNA, Small Interfering; D011948:Receptors, Antigen, T-Cell; D013844:Thiazoles; D003907:Dexamethasone; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D000069439:Dasatinib