Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation.
Kingsbury
Joanne M
JM
Department of Molecular Genetics and Microbiology, Box 3020, Duke University Medical Center, Durham, NC 27710, USA.
McCusker
John H
JH
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002176:Candida albicans / Q000166:cytology / Q000187:drug effects / Q000201:enzymology* / Q000472:pathogenicity*; D002614:Chelating Agents / Q000494:pharmacology; D005437:Flucytosine / Q000378:metabolism; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D051379:Mice; D050296:Microbial Viability / Q000187:drug effects; D009154:Mutation / Q000235:genetics*; D010641:Phenotype; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics*; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000187:drug effects / Q000201:enzymology* / Q000472:pathogenicity*; D044967:Serum / Q000378:metabolism; D013912:Threonine / Q000172:deficiency* / Q000494:pharmacology; D014774:Virulence / Q000187:drug effects
D002614:Chelating Agents; D013912:Threonine; D005437:Flucytosine; D017853:Phosphotransferases (Alcohol Group Acceptor); C021370:homoserine kinase; D002118:Calcium