title: Constitutive glycogen synthase kinase-3alpha/beta activity protects against chronic beta-adrenergic remodelling of the heart.
authors.affiliation: Division of Cardiology, King's College London BHF Centre, The Rayne Institute, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK.
authors.forename: Ian G
authors.initials: IG
authors.lastname: Webb
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Nishino
authors.forename: James E
authors.initials: JE
authors.lastname: Clark
authors.forename: Colin
authors.initials: C
authors.lastname: Murdoch
authors.forename: Simon J
authors.initials: SJ
authors.lastname: Walker
authors.forename: Marcus R
authors.initials: MR
authors.lastname: Makowski
authors.forename: Rene M
authors.initials: RM
authors.lastname: Botnar
authors.forename: Simon R
authors.initials: SR
authors.lastname: Redwood
authors.forename: Ajay M
authors.initials: AM
authors.lastname: Shah
authors.forename: Michael S
authors.initials: MS
authors.lastname: Marber
mesh_terms: D000318:Adrenergic beta-Agonists; D000367:Age Factors; D000818:Animals; D017209:Apoptosis; D006332:Cardiomegaly / Q000139:chemically induced / Q000201:enzymology* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004789:Enzyme Activation; D005355:Fibrosis; D005786:Gene Expression Regulation; D005838:Genotype; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D000071679:Glycogen Synthase Kinase 3 beta; D006339:Heart Rate; D007545:Isoproterenol; D051379:Mice; D008822:Mice, Transgenic; D009200:Myocardial Contraction; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology; D010641:Phenotype; D010766:Phosphorylation; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D013318:Stroke Volume; D016276:Ventricular Function; D020257:Ventricular Remodeling
chemical_list: D000318:Adrenergic beta-Agonists; D047428:Protein Kinase Inhibitors; D000071679:Glycogen Synthase Kinase 3 beta; C000605507:Gsk3b protein, mouse; D038362:Glycogen Synthase Kinase 3; C448021:glycogen synthase kinase 3 alpha; D007545:Isoproterenol