Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
Blum
Charles A
CA
Neurogen Corporation, 35 Northeast Industrial Road, Branford, Connecticut 06405, USA.
Caldwell
Timothy
T
Zheng
Xiaozhang
X
Bakthavatchalam
Rajagopal
R
Capitosti
Scott
S
Brielmann
Harry
H
De Lombaert
Stéphane
S
Kershaw
Mark T
MT
Matson
David
D
Krause
James E
JE
Cortright
Daniel
D
Crandall
Marci
M
Martin
William J
WJ
Murphy
Beth Ann
BA
Boyce
Susan
S
Jones
A Brian
AB
Mason
Glenn
G
Rycroft
Wayne
W
Perrett
Helen
H
Conley
Rachael
R
Burnaby-Davies
Nicola
N
Chenard
Bertrand L
BL
Hodgetts
Kevin J
KJ
D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001682:Biological Availability; D019556:COS Cells; D002211:Capsaicin / Q000494:pharmacology; D002522:Chlorocebus aethiops; D006358:Hot Temperature; D006801:Humans; D006930:Hyperalgesia / Q000188:drug therapy; D066298:In Vitro Techniques; D007249:Inflammation / Q000188:drug therapy; D008862:Microsomes, Liver; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D050916:TRPV Cation Channels / Q000819:agonists / Q000037:antagonists & inhibitors*
C549346:7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1,8-naphthyridin-4-amine; D000700:Analgesics; D009287:Naphthyridines; D011719:Pyrazines; D011725:Pyridines; D011743:Pyrimidines; D011799:Quinazolines; D011804:Quinolines; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; C493922:Trpv1 protein, rat; D002211:Capsaicin