Inducible dimerization and inducible cleavage reveal a requirement for both processes in caspase-8 activation.
Oberst
Andrew
A
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Pop
Cristina
C
Tremblay
Alexandre G
AG
Blais
Véronique
V
Denault
Jean-Bernard
JB
Salvesen
Guy S
GS
Green
Douglas R
DR
D017209:Apoptosis; D001665:Binding Sites; D053181:Caspase 8 / Q000378:metabolism*; D020169:Caspases / Q000378:metabolism; D020134:Catalytic Domain; D002460:Cell Line; D019281:Dimerization; D010450:Endopeptidases / Q000378:metabolism; D004789:Enzyme Activation; D006367:HeLa Cells; D006801:Humans; D019169:Jurkat Cells; D008954:Models, Biological; D009154:Mutation; D017434:Protein Structure, Tertiary
D010450:Endopeptidases; C099488:TEV protease; D053181:Caspase 8; D020169:Caspases