title: Novel benzofuran-3-one indole inhibitors of PI3 kinase-alpha and the mammalian target of rapamycin: hit to lead studies.
authors.affiliation: Medicinal Chemistry, Chemical Sciences, Wyeth Research, Pearl River, NY 10965, USA.
authors.forename: Matthew G
authors.initials: MG
authors.lastname: Bursavich
authors.forename: Natasja
authors.initials: N
authors.lastname: Brooijmans
authors.forename: Lawrence
authors.initials: L
authors.lastname: Feldberg
authors.forename: Irwin
authors.initials: I
authors.lastname: Hollander
authors.forename: Stephen
authors.initials: S
authors.lastname: Kim
authors.forename: Sabrina
authors.initials: S
authors.lastname: Lombardi
authors.forename: Kaapjoo
authors.initials: K
authors.lastname: Park
authors.forename: Robert
authors.initials: R
authors.lastname: Mallon
authors.forename: Adam M
authors.initials: AM
authors.lastname: Gilbert
mesh_terms: D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors*; D008958:Models, Molecular; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D058570:TOR Serine-Threonine Kinases
chemical_list: D001572:Benzofurans; D047908:Intracellular Signaling Peptides and Proteins; D000081082:Phosphoinositide-3 Kinase Inhibitors; D047428:Protein Kinase Inhibitors; C546842:MTOR protein, human; D017346:Protein Serine-Threonine Kinases; D058570:TOR Serine-Threonine Kinases