Synthesis of 26-hydroxy-22-oxocholestanic frameworks from diosgenin and hecogenin and their in vitro antiproliferative and apoptotic activity on human cervical cancer CaSki cells.
Fernández-Herrera
María A
MA
Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Ciudad Universitaria, 72570 Puebla, Pue., Mexico.
López-Muñoz
Hugo
H
Hernández-Vázquez
José M V
JM
López-Dávila
Moisés
M
Escobar-Sánchez
María L
ML
Sánchez-Sánchez
Luis
L
Pinto
B Mario
BM
Sandoval-Ramírez
Jesús
J
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002240:Carbohydrate Sequence; D053148:Caspase 3 / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002777:Cholestanols / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D053938:DNA Fragmentation / Q000187:drug effects; D004144:Diosgenin / Q000737:chemistry*; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D005456:Fluorescent Dyes; D006801:Humans; D020287:In Situ Nick-End Labeling; D007211:Indoles; D008214:Lymphocytes / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D012502:Sapogenins / Q000737:chemistry*; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy / Q000473:pathology
D000972:Antineoplastic Agents, Phytogenic; D002777:Cholestanols; D005456:Fluorescent Dyes; D007211:Indoles; D012502:Sapogenins; D013256:Steroids; C007908:hecogenin; C007293:DAPI; D053148:Caspase 3; D004144:Diosgenin