B-Raf kinase inhibitors: hit enrichment through scaffold hopping.
Gopalsamy
Ariamala
A
Chemical Sciences, Wyeth Research, Pearl River, NY 10965, USA. gopalsa@wyeth.com
Shi
Mengxiao
M
Hu
Yongbo
Y
Lee
Frederick
F
Feldberg
Larry
L
Frommer
Eileen
E
Kim
Steven
S
Collins
Karen
K
Wojciechowicz
Donald
D
Mallon
Robert
R
D008958:Models, Molecular; D047428:Protein Kinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D048493:Proto-Oncogene Proteins B-raf / Q000037:antagonists & inhibitors*; D011743:Pyrimidines / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D047428:Protein Kinase Inhibitors; D011743:Pyrimidines; D048493:Proto-Oncogene Proteins B-raf