The antinociceptive effect of a benzopyran (HP1) isolated from Hypericum polyanthemum in mice hot-plate test is blocked by naloxone.
Haas
Juliana Schulte
JS
Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Viana
Alice Fialho
AF
Heckler
Ana Paula Machado
AP
von Poser
Gilsane Lino
GL
Rates
Stela Maris Kuze
SM
D019342:Acetic Acid; D000701:Analgesics, Opioid / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001578:Benzopyrans / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D020902:Hypericum / Q000737:chemistry*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
C539958:6-isobutyryl-5,7-dimethoxy-2,2-dimethyl-benzopyran; D000701:Analgesics, Opioid; D001578:Benzopyrans; D009292:Narcotic Antagonists; D010936:Plant Extracts; D009270:Naloxone; D019342:Acetic Acid