Extrapolating in vitro metabolic interactions to isolated perfused liver: predictions of metabolic interactions between R-bufuralol, bunitrolol, and debrisoquine.
Haddad
Sami
S
Department of Biological Sciences, Centre TOXEN, Université du Québec à Montréal, Montréal, Québec, Canada. haddad.sami@uqam.ca
Poulin
Patrick
P
Funk
Christoph
C
D000317:Adrenergic alpha-Antagonists / Q000493:pharmacokinetics / Q000494:pharmacology*; D000319:Adrenergic beta-Antagonists / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D003647:Debrisoquin / Q000493:pharmacokinetics / Q000494:pharmacology*; D004347:Drug Interactions; D004983:Ethanolamines / Q000493:pharmacokinetics / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D011412:Propanolamines / Q000493:pharmacokinetics / Q000494:pharmacology*; D051381:Rats
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D004983:Ethanolamines; D011412:Propanolamines; C010831:bufuralol; C084811:bunitrolol; D003647:Debrisoquin