Tyrosines 868, 966, and 972 in the kinase domain of JAK2 are autophosphorylated and required for maximal JAK2 kinase activity.
Argetsinger
Lawrence S
LS
Department of Molecular and Integrative Physiology, The University of Michigan Medical School, Ann Arbor, Michigan 48109-5622, USA.
Stuckey
Jeanne A
JA
Robertson
Scott A
SA
Koleva
Rositsa I
RI
Cline
Joel M
JM
Marto
Jarrod A
JA
Myers
Martin G
MG
Carter-Su
Christin
C
D000818:Animals; D015153:Blotting, Western; D002460:Cell Line; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D047468:Immunoprecipitation; D053614:Janus Kinase 2 / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D016297:Mutagenesis, Site-Directed; D010748:Phosphopeptides / Q000737:chemistry / Q000378:metabolism; D010766:Phosphorylation; D011485:Protein Binding / Q000235:genetics / Q000502:physiology; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary / Q000235:genetics / Q000502:physiology; D051381:Rats; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D013329:Structure-Activity Relationship; D053719:Tandem Mass Spectrometry; D014443:Tyrosine / Q000737:chemistry / Q000378:metabolism*
D010748:Phosphopeptides; D014443:Tyrosine; D013006:Growth Hormone; D053614:Janus Kinase 2