Conjugates of plumbagin and phenyl-2-amino-1-thioglucoside inhibit MshB, a deacetylase involved in the biosynthesis of mycothiol.
Gammon
David W
DW
Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa. david.gammon@uct.ac.za
Steenkamp
Daniel J
DJ
Mavumengwana
Vuyo
V
Marakalala
Mohlopheni J
MJ
Mudzunga
Theophilus T
TT
Hunter
Roger
R
Munyololo
Muganza
M
D000111:Acetylcysteine / Q000737:chemistry; D000581:Amidohydrolases / Q000037:antagonists & inhibitors* / Q000302:isolation & purification; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors* / Q000302:isolation & purification; D002470:Cell Survival; D003545:Cysteine / Q000096:biosynthesis*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006020:Glycopeptides / Q000096:biosynthesis*; D007202:Indicators and Reagents; D007294:Inositol / Q000096:biosynthesis* / Q000737:chemistry; D009169:Mycobacterium tuberculosis / Q000201:enzymology; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology*; D010084:Oxidation-Reduction; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D013863:Thioglucosides / Q000138:chemical synthesis / Q000494:pharmacology
D001426:Bacterial Proteins; D004791:Enzyme Inhibitors; D006020:Glycopeptides; D007202:Indicators and Reagents; D009285:Naphthoquinones; D013863:Thioglucosides; C089265:mycothiol; D007294:Inositol; D009247:NADH, NADPH Oxidoreductases; C089267:disulfide reductase, mycothiol; D000581:Amidohydrolases; C417275:N-acetyl-1-D-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase; C413523:mycothiol S-conjugate amidase; D003545:Cysteine; D000111:Acetylcysteine; C014758:plumbagin