A novel microtubule-modulating agent induces mitochondrially driven caspase-dependent apoptosis via mitotic checkpoint activation in human prostate cancer cells.
Aneja
Ritu
R
Department of Biology, Georgia State University, Atlanta, GA 30303, USA. raneja@gsu.edu
Miyagi
Tohru
T
Karna
Prasanthi
P
Ezell
Tucker
T
Shukla
Deep
D
Vij Gupta
Meenakshi
M
Yates
Clayton
C
Chinni
Sreenivasa R
SR
Zhau
Haiyen
H
Chung
Leland W K
LW
Joshi
Harish C
HC
D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D053148:Caspase 3 / Q000378:metabolism*; D045744:Cell Line, Tumor; D004149:Dioxoles / Q000494:pharmacology*; D016195:G2 Phase / Q000187:drug effects; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008928:Mitochondria / Q000201:enzymology*; D008938:Mitosis / Q000187:drug effects; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D050257:Tubulin Modulators / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays / Q000379:methods
D004149:Dioxoles; C510553:EM011 compound; D007546:Isoquinolines; D050257:Tubulin Modulators; D053148:Caspase 3