Increased expression of plasminogen activator inhibitor type-1 (PAI-1) in HEPG2 cells induced by insulin mediated by the 3'-untranslated region of the PAI-1 gene and its pharmacologic implications.
Miyagawa
Ryu
R
aDepartment of Molecular and Cellular Pathobiology and Therapeutics, Nagoya City University School of Pharmaceutical Sciences, Nagoya, Japan.
Asakura
Takefumi
T
Nakamura
Tomomi
T
Okada
Hiromi
H
Iwaki
Soichiro
S
Sobel
Burton E
BE
Fujii
Satoshi
S
D020413:3' Untranslated Regions / Q000187:drug effects; D001665:Binding Sites; D015153:Blotting, Western; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism*; D002317:Cardiovascular Agents / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D017930:Genes, Reporter; D056945:Hep G2 Cells; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D017395:Plasminogen Activator Inhibitor 1 / Q000235:genetics / Q000378:metabolism*; D011401:Promoter Regions, Genetic / Q000187:drug effects; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019821:Simvastatin / Q000494:pharmacology; D015854:Up-Regulation
D020413:3' Untranslated Regions; D002317:Cardiovascular Agents; D007328:Insulin; D017395:Plasminogen Activator Inhibitor 1; D012333:RNA, Messenger; C051321:SERPINE1 protein, human; D019821:Simvastatin; D000242:Cyclic AMP