Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and of Ras farnesylation mediate antitumor effects of anandamide in human breast cancer cells.
Laezza
Chiara
C
Institute of Endocrinology e Experimental Oncology, CNR, Via Pansini 5, 80131 Naples, Italy. chilaez@libero.it
Malfitano
Anna Maria
AM
Proto
Maria Chiara
MC
Esposito
Iolanda
I
Gazzerro
Patrizia
P
Formisano
Pietro
P
Pisanti
Simona
S
Santoro
Antonietta
A
Caruso
Maria Gabriella
MG
Bifulco
Maurizio
M
D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000970:Antineoplastic Agents / Q000494:pharmacology; D001095:Arachidonic Acids / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D063385:Cannabinoid Receptor Modulators / Q000494:pharmacology; D002277:Carcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D015536:Down-Regulation / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D063388:Endocannabinoids; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics / Q000378:metabolism; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides / Q000494:pharmacology*; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism
C551918:2-methyl-2'-F-anandamide; D000970:Antineoplastic Agents; D001095:Arachidonic Acids; D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D004791:Enzyme Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D053284:Polyunsaturated Alkamides; D006903:Hydroxymethylglutaryl CoA Reductases; D019883:Alkyl and Aryl Transferases; C083291:geranylgeranyltransferase type-I; D018631:ras Proteins; C078814:anandamide