The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.
Cain
Robert J
RJ
Randall Division of Cell and Molecular Biophysics, King's College London, London SE1 1UL, England, UK.
Vanhaesebroeck
Bart
B
Ridley
Anne J
AJ
D022005:Adherens Junctions / Q000378:metabolism*; D002199:Capillary Permeability; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000378:metabolism*; D051418:Focal Adhesion Kinase 2 / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D020830:rac1 GTP-Binding Protein / Q000378:metabolism*
D007527:Isoenzymes; C107953:RAC1 protein, human; D014409:Tumor Necrosis Factor-alpha; D019869:Phosphatidylinositol 3-Kinases; D051418:Focal Adhesion Kinase 2; D020830:rac1 GTP-Binding Protein