Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor.
Eng
H
H
Pharmacokinetics, Dynamics and Metabolism, Groton, CT, USA.
Niosi
M
M
McDonald
T S
TS
Wolford
A
A
Chen
Y
Y
Simila
S T M
ST
Bauman
J N
JN
Warmus
J
J
Kalgutkar
A S
AS
D000818:Animals; D043182:Carboxylesterase / Q000037:antagonists & inhibitors*; D004285:Dogs; D004355:Drug Stability; D005260:Female; D006801:Humans; D006868:Hydrolysis; D007546:Isoquinolines / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D009249:NADP / Q000494:pharmacology; D009596:Nitrophenols / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010084:Oxidation-Reduction; D011804:Quinolines / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D043562:Receptors, G-Protein-Coupled / Q000819:agonists; D014230:Triazoles / Q000494:pharmacology
C551632:1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone; C473772:GPBAR1 protein, human; D007546:Isoquinolines; D009596:Nitrophenols; D009943:Organophosphorus Compounds; D011804:Quinolines; D043562:Receptors, G-Protein-Coupled; D014230:Triazoles; C033020:1-aminobenzotriazole; C008644:nitrophenylphosphate; D009249:NADP; D043182:Carboxylesterase