Novel 8-(furan-2-yl)-3-substituted thiazolo [5,4-e][1,2,4] triazolo[1,5-c] pyrimidine-2(3H)-thione derivatives as potential adenosine A(2A) receptor antagonists.
Mishra
Chandra Bhushan
CB
Medicinal Chemistry Division, Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, North Campus, Mall Road, Delhi 110 007, India.
Barodia
Sandeep Kumar
SK
Prakash
Amresh
A
Senthil Kumar
J B
JB
Luthra
Pratibha Mehta
PM
D058917:Adenosine A2 Receptor Antagonists; D000818:Animals; D014150:Antipsychotic Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced / Q000517:prevention & control; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002855:Chromatography, Thin Layer; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D000242:Cyclic AMP / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D004409:Dyskinesia, Drug-Induced / Q000517:prevention & control; D006220:Haloperidol / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008958:Models, Molecular; D009043:Motor Activity / Q000187:drug effects; D011485:Protein Binding; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011869:Radioligand Assay; D013329:Structure-Activity Relationship; D013871:Thiones / Q000138:chemical synthesis* / Q000494:pharmacology*
C550371:8-(furan-2-yl)-3-thiazolo (5,4-e)(1,2,4)triazolo(1,5-c)pyrimidine-2(3H)-thione; D058917:Adenosine A2 Receptor Antagonists; D014150:Antipsychotic Agents; D011743:Pyrimidines; D013871:Thiones; D000242:Cyclic AMP; D006220:Haloperidol