Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels.
Bu
Shizhong
S
Medical University of South Carolina, Charleston, USA.
Asano
Yoshihide
Y
Bujor
Andreea
A
Highland
Kristin
K
Hant
Faye
F
Trojanowska
Maria
M
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002478:Cells, Cultured; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D012595:Scleroderma, Systemic / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D015854:Up-Regulation / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; C060504:dihydrosphingosine 1-phosphate; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human; D013110:Sphingosine