Determination of beta-artemether and its main metabolite dihydroartemisinin in plasma employing liquid-phase microextraction prior to liquid chromatographic-tandem mass spectrometric analysis.
Magalhães
Igor R S
IR
Faculty of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo - USP, Ribeirão Preto, SP, Brazil.
Jabor
Valquíria A P
VA
Faria
Anizio M
AM
Collins
Carol H
CH
Jardim
Isabel C S F
IC
Bonato
Pierina S
PS
D000818:Animals; D000077549:Artemether; D037621:Artemisinins / Q000737:chemistry*; D002138:Calibration; D005591:Chemical Fractionation / Q000379:methods*; D002623:Chemistry Techniques, Analytical; D002853:Chromatography, Liquid / Q000379:methods*; D006801:Humans; D057230:Limit of Detection; D013058:Mass Spectrometry / Q000379:methods*; D011786:Quality Control; D051381:Rats; D015203:Reproducibility of Results; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D014050:Toluene / Q000737:chemistry
D037621:Artemisinins; D014050:Toluene; C031327:artemisinin; D000077549:Artemether