Decreased phospho-Akt signaling in a mouse model of total parenteral nutrition: a potential mechanism for the development of intestinal mucosal atrophy.
Feng
Yongjia
Y
Section of Pediatric Surgery, Univ. of Michigan, Mott Children's Hospital F3970, Ann Arbor, MI 48109-5245, USA.
McDunn
Jonathan E
JE
Teitelbaum
Daniel H
DH
D000818:Animals; D001284:Atrophy / Q000139:chemically induced / Q000473:pathology; D049109:Cell Proliferation; D004847:Epithelial Cells / Q000187:drug effects / Q000502:physiology; D005786:Gene Expression Regulation / Q000187:drug effects; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology*; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D010766:Phosphorylation; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000494:pharmacology*; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism*; D011897:Random Allocation; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D013047:Specific Pathogen-Free Organisms; D058570:TOR Serine-Threonine Kinases; D015534:Trans-Activators / Q000494:pharmacology; D051153:Wnt Proteins / Q000235:genetics / Q000378:metabolism; D051176:beta Catenin / Q000235:genetics / Q000378:metabolism
D047908:Intracellular Signaling Peptides and Proteins; D011518:Proto-Oncogene Proteins; C490393:Tcl1 protein, mouse; D015534:Trans-Activators; D051153:Wnt Proteins; D051176:beta Catenin; C546843:mTOR protein, mouse; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D058570:TOR Serine-Threonine Kinases