title: Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity.
authors.affiliation: Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.
authors.forename: Rebecca A
authors.initials: RA
authors.lastname: Stockton
authors.forename: Robert
authors.initials: R
authors.lastname: Shenkar
authors.forename: Issam A
authors.initials: IA
authors.lastname: Awad
authors.forename: Mark H
authors.initials: MH
authors.lastname: Ginsberg
mesh_terms: D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D000825:Animal Structures / Q000098:blood supply / Q000378:metabolism; D000818:Animals; D001929:Brain Edema / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D002199:Capillary Permeability / Q000187:drug effects / Q000502:physiology*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D004489:Edema, Cardiac / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D020786:Hemangioma, Cavernous, Central Nervous System / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D006801:Humans; D000075927:KRIT1 Protein; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism; D009154:Mutation / Q000502:physiology; D018994:Myosin Light Chains / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects / Q000235:genetics; D011485:Protein Binding / Q000502:physiology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D011654:Pulmonary Edema / Q000235:genetics / Q000473:pathology; D034741:RNA, Small Interfering / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D054460:rho-Associated Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D020742:rhoA GTP-Binding Protein / Q000378:metabolism*
chemical_list: C459092:2-methyl-1-((4-methyl-5-isoquinolinyl)sulfonyl)homopiperazine; C502544:CCM2 protein, human; D002352:Carrier Proteins; D000075927:KRIT1 Protein; C107928:KRIT1 protein, human; C491535:Krit1 protein, mouse; D008840:Microfilament Proteins; D008869:Microtubule-Associated Proteins; D018994:Myosin Light Chains; D047428:Protein Kinase Inhibitors; D011518:Proto-Oncogene Proteins; D034741:RNA, Small Interfering; C480498:osmosensing scaffold for MEKK3 protein, mouse; C066737:RHOA protein, human; D019307:1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; D054460:rho-Associated Kinases; D020742:rhoA GTP-Binding Protein; C049347:fasudil