title: Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid differentiation protein-2 (MD-2).
authors.affiliation: Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA.
authors.forename: Michael R
authors.initials: MR
authors.lastname: Peluso
authors.forename: Cristobal L
authors.initials: CL
authors.lastname: Miranda
authors.forename: Deborah J
authors.initials: DJ
authors.lastname: Hobbs
authors.forename: Rosita R
authors.initials: RR
authors.lastname: Proteau
authors.forename: Jan Frederik
authors.initials: JF
authors.lastname: Stevens
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D018932:Chemokine CCL2 / Q000096:biosynthesis; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D027582:Humulus / Q000737:chemistry; D015850:Interleukin-6 / Q000096:biosynthesis; D008070:Lipopolysaccharides / Q000494:pharmacology; D051218:Lymphocyte Antigen 96 / Q000737:chemistry* / Q000378:metabolism; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D054876:Prenylation; D011427:Propiophenones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D005419:Flavonoids; D015850:Interleukin-6; D008070:Lipopolysaccharides; D051218:Lymphocyte Antigen 96; D011427:Propiophenones; C104536:xanthohumol