Using a rate-frequency curve method to assess the rewarding properties of morphine in the intracranial self-stimulation paradigm in rats.
O'Neill
Krystal S
KS
Department of Life Sciences and Toxicology, Alkermes, Inc., 852 Winter Street, Waltham, MA 02451, USA.
Todtenkopf
Mark S
MS
D000818:Animals; D016477:Artifacts; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology; D016292:Procedural Sedation / Q000009:adverse effects / Q000379:methods; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004558:Electric Stimulation; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods; D005010:Ethology / Q000379:methods*; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009294:Narcotics / Q000494:pharmacology; D009480:Neuropharmacology / Q000379:methods*; D009484:Neuropsychology / Q000379:methods; D051381:Rats; D017208:Rats, Wistar; D012054:Reinforcement, Psychology; D012201:Reward; D012653:Self Stimulation / Q000502:physiology*
D006993:Hypnotics and Sedatives; D009294:Narcotics; D009020:Morphine