Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process.
Pastorin
Giorgia
G
Department of Pharmacy, National University of Singapore, Block S4, 18 Science Drive 4, Singapore.
Federico
Stephanie
S
Paoletta
Silvia
S
Corradino
Marta
M
Cateni
Francesca
F
Cacciari
Barbara
B
Klotz
Karl-Norbert
KN
Gao
Zhan-Guo
ZG
Jacobson
Kenneth A
KA
Spalluto
Giampiero
G
Moro
Stefano
S
D058917:Adenosine A2 Receptor Antagonists; D058918:Adenosine A3 Receptor Antagonists; D000067956:Adenylyl Cyclase Inhibitors; D000595:Amino Acid Sequence; D000818:Animals; D016466:CHO Cells; D002460:Cell Line; D002855:Chromatography, Thin Layer; D019295:Computational Biology; D006224:Cricetinae; D003412:Cricetulus; D018360:Crystallography, X-Ray; D007202:Indicators and Reagents; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008969:Molecular Sequence Data; D058915:Purinergic P1 Receptor Antagonists; D051381:Rats; D018047:Receptors, Purinergic P1 / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology*
D058917:Adenosine A2 Receptor Antagonists; D058918:Adenosine A3 Receptor Antagonists; D000067956:Adenylyl Cyclase Inhibitors; D007202:Indicators and Reagents; D008024:Ligands; D058915:Purinergic P1 Receptor Antagonists; D018047:Receptors, Purinergic P1; D014227:Triazines