Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation.
Hod
Eldad A
EA
Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. eh2217@columbia.edu
Zhang
Ning
N
Sokol
Set A
SA
Wojczyk
Boguslaw S
BS
Francis
Richard O
RO
Ansaldi
Daniel
D
Francis
Kevin P
KP
Della-Latta
Phyllis
P
Whittier
Susan
S
Sheth
Sujit
S
Hendrickson
Jeanne E
JE
Zimring
James C
JC
Brittenham
Gary M
GM
Spitalnik
Steven L
SL
D000210:Acute-Phase Reaction / Q000097:blood / Q000209:etiology; D000818:Animals; D001793:Blood Preservation / Q000009:adverse effects*; D003676:Deferoxamine / Q000494:pharmacology; D004195:Disease Models, Animal; D019446:Endotoxemia / Q000097:blood / Q000209:etiology; D004731:Endotoxins / Q000097:blood; D004905:Erythrocyte Aging; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D004927:Escherichia coli Infections / Q000097:blood / Q000209:etiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology* / Q000517:prevention & control; D018836:Inflammation Mediators / Q000097:blood; D007501:Iron / Q000097:blood* / Q000378:metabolism; D007502:Iron Chelating Agents / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008954:Models, Biological; D013154:Spleen / Q000378:metabolism; D013997:Time Factors
D004731:Endotoxins; D006454:Hemoglobins; D018836:Inflammation Mediators; D007502:Iron Chelating Agents; D007501:Iron; D003676:Deferoxamine