The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.
Vivanco
Igor
I
Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
Rohle
Daniel
D
Versele
Matthias
M
Iwanami
Akio
A
Kuga
Daisuke
D
Oldrini
Barbara
B
Tanaka
Kazuhiro
K
Dang
Julie
J
Kubek
Sara
S
Palaskas
Nicolaos
N
Hsueh
Teli
T
Evans
Michael
M
Mulholland
David
D
Wolle
Daniel
D
Rajasekaran
Sigrid
S
Rajasekaran
Ayyappan
A
Liau
Linda M
LM
Cloughesy
Timothy F
TF
Dikic
Ivan
I
Brennan
Cameron
C
Wu
Hong
H
Mischel
Paul S
PS
Perera
Timothy
T
Mellinghoff
Ingo K
IK
D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D004789:Enzyme Activation; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D051059:PTEN Phosphohydrolase / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D050721:Proto-Oncogene Proteins c-cbl / Q000378:metabolism; D034622:RNA Interference; D015398:Signal Transduction / Q000187:drug effects; D054875:Ubiquitination
D047428:Protein Kinase Inhibitors; D050721:Proto-Oncogene Proteins c-cbl; C512478:EGFR protein, human; D066246:ErbB Receptors; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human; C487757:Pten protein, mouse; C067419:CBL protein, human