title: Thymidylate synthase (TYMS) enhancer region genotype-directed phase II trial of oral capecitabine for 2nd line treatment of advanced pancreatic cancer.
authors.affiliation: University of Colorado Cancer Center, 12801 E 17th Avenue, RC-1 South, Rm 8123, MS 8117, Aurora, CO 80045, USA. colin.weekes@ucdenver.edu
authors.forename: Colin D
authors.initials: CD
authors.lastname: Weekes
authors.forename: Sujatha
authors.initials: S
authors.lastname: Nallapareddy
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Rudek
authors.forename: Alexis
authors.initials: A
authors.lastname: Norris-Kirby
authors.forename: Daniel
authors.initials: D
authors.lastname: Laheru
authors.forename: Antonio
authors.initials: A
authors.lastname: Jimeno
authors.forename: Ross C
authors.initials: RC
authors.lastname: Donehower
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Murphy
authors.forename: Manuel
authors.initials: M
authors.lastname: Hidalgo
authors.forename: Sharyn D
authors.initials: SD
authors.lastname: Baker
authors.forename: Wells A
authors.initials: WA
authors.lastname: Messersmith
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000069287:Capecitabine; D003710:Demography; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004742:Enhancer Elements, Genetic / Q000235:genetics*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics / Q000473:pathology*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D016019:Survival Analysis; D013940:Thymidylate Synthase / Q000235:genetics*; D016896:Treatment Outcome; D000093542:Gemcitabine
chemical_list: D000970:Antineoplastic Agents; D003841:Deoxycytidine; D000069287:Capecitabine; D013940:Thymidylate Synthase; D005472:Fluorouracil; D000093542:Gemcitabine