Slow binding-tight binding interaction between benzimidazol-2-one inhibitors and HIV-1 reverse transcriptase containing the lysine 103 to asparagine mutation.
Samuele
Alberta
A
Department of DNA Enzymology and Molecular Virology, Institute of Molecular Genetics-National Research Council, IGM-CNR, via Abbiategrasso 207, 27100 Pavia, Italy.
Crespan
Emmanuele
E
Vitellaro
Samanta
S
Monforte
Anna-Maria
AM
Logoteta
Patrizia
P
Chimirri
Alba
A
Maga
Giovanni
G
D019943:Amino Acid Substitution / Q000235:genetics*; D001216:Asparagine / Q000235:genetics; D001562:Benzimidazoles / Q000378:metabolism*; D002460:Cell Line; D002470:Cell Survival; D054303:HIV Reverse Transcriptase / Q000378:metabolism*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008239:Lysine / Q000235:genetics; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D015394:Molecular Structure; D050505:Mutant Proteins / Q000378:metabolism; D020125:Mutation, Missense; D011485:Protein Binding; D018894:Reverse Transcriptase Inhibitors / Q000378:metabolism*
D001562:Benzimidazoles; D050505:Mutant Proteins; D018894:Reverse Transcriptase Inhibitors; C053110:benzimidazol-2-one; D001216:Asparagine; C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase; D008239:Lysine