Polychlorinated biphenyls disrupt intestinal integrity via NADPH oxidase-induced alterations of tight junction protein expression.
Choi
Yean Jung
YJ
Department of Neurosurgery, University of Kentucky, Lexington, 40536, USA.
Seelbach
Melissa J
MJ
Pu
Hong
H
Eum
Sung Yong
SY
Chen
Lei
L
Zhang
Bei
B
Hennig
Bernhard
B
Toborek
Michal
M
D000704:Analysis of Variance; D000818:Animals; D015153:Blotting, Western; D018938:Caco-2 Cells; D004591:Electrophoresis, Polyacrylamide Gel; D004785:Environmental Pollutants / Q000633:toxicity*; D004789:Enzyme Activation / Q000187:drug effects; D005455:Fluorescent Antibody Technique; D006801:Humans; D007150:Immunohistochemistry; D047468:Immunoprecipitation; D007413:Intestinal Mucosa / Q000187:drug effects*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D019255:NADPH Oxidases / Q000378:metabolism*; D062793:Occludin; D010750:Phosphoproteins / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D019108:Tight Junctions / Q000187:drug effects*; D062826:Zonula Occludens-1 Protein
D004785:Environmental Pollutants; D008565:Membrane Proteins; C568985:OCLN protein, human; D062793:Occludin; C568986:Ocln protein, mouse; D010750:Phosphoproteins; C569042:TJP1 protein, human; C569043:Tjp1 protein, mouse; D062826:Zonula Occludens-1 Protein; D011078:Polychlorinated Biphenyls; D019255:NADPH Oxidases