title: Phosphatidic acid is a leukocyte chemoattractant that acts through S6 kinase signaling.
authors.affiliation: Department of Biochemistry and Molecular Biology, Wright State University School of Medicine, Dayton, Ohio 45435, USA.
authors.forename: Kathleen
authors.initials: K
authors.lastname: Frondorf
authors.forename: Karen M
authors.initials: KM
authors.lastname: Henkels
authors.forename: Michael A
authors.initials: MA
authors.lastname: Frohman
authors.forename: Julian
authors.initials: J
authors.lastname: Gomez-Cambronero
mesh_terms: D000199:Actins / Q000378:metabolism; D002630:Chemotactic Factors / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D002633:Chemotaxis / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects / Q000502:physiology; D018922:HL-60 Cells; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology; D008301:Maleimides / Q000494:pharmacology; D020125:Mutation, Missense; D009504:Neutrophils / Q000201:enzymology* / Q000276:immunology; D010712:Phosphatidic Acids / Q000276:immunology / Q000378:metabolism*; D010739:Phospholipase D / Q000096:biosynthesis; D019893:Ribosomal Protein S6 Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015290:Second Messenger Systems / Q000502:physiology*; D020123:Sirolimus / Q000494:pharmacology; D013302:Streptomyces / Q000276:immunology / Q000378:metabolism
chemical_list: D000199:Actins; D002630:Chemotactic Factors; D007166:Immunosuppressive Agents; D007211:Indoles; D008301:Maleimides; D010712:Phosphatidic Acids; D019893:Ribosomal Protein S6 Kinases; C105606:phospholipase D2; D010739:Phospholipase D; C106801:phospholipase D1; C088060:bisindolylmaleimide; D020123:Sirolimus