Regulation of phenylalanine hydroxylase: conformational changes upon phenylalanine binding detected by hydrogen/deuterium exchange and mass spectrometry.
Li
Jun
J
Department of Biochemistry and Biophysics, Texas A&M University, College Station,Texas 77843-2128, USA.
Dangott
Lawrence J
LJ
Fitzpatrick
Paul F
PF
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D020134:Catalytic Domain; D003903:Deuterium; D006859:Hydrogen; D007700:Kinetics; D013058:Mass Spectrometry; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010649:Phenylalanine / Q000737:chemistry / Q000378:metabolism*; D010651:Phenylalanine Hydroxylase / Q000737:chemistry* / Q000378:metabolism*; D011487:Protein Conformation; D051381:Rats
D010649:Phenylalanine; D006859:Hydrogen; D003903:Deuterium; D010651:Phenylalanine Hydroxylase