Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone.
Kodaira
Hiroshi
H
Pharmacokinetic Research Laboratories, Research Division, Kyowa Hakko Kirin Co., Ltd., Shizuoka, Japan.
Kusuhara
Hiroyuki
H
Ushiki
Junko
J
Fuse
Eiichi
E
Sugiyama
Yuichi
Y
D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics / Q000378:metabolism*; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism*; D000465:Algorithms; D000818:Animals; D000962:Antimalarials / Q000493:pharmacokinetics; D000970:Antineoplastic Agents / Q000493:pharmacokinetics*; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D003620:Dantrolene / Q000493:pharmacokinetics; D000069347:Erlotinib Hydrochloride; D005419:Flavonoids / Q000493:pharmacokinetics*; D007700:Kinetics; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008942:Mitoxantrone / Q000493:pharmacokinetics*; D009125:Muscle Relaxants, Central / Q000493:pharmacokinetics; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*; D010880:Piperidines / Q000493:pharmacokinetics*; D047428:Protein Kinase Inhibitors / Q000493:pharmacokinetics*; D011799:Quinazolines / Q000493:pharmacokinetics*; D011802:Quinidine / Q000493:pharmacokinetics; D013737:Testis / Q000378:metabolism*; D014018:Tissue Distribution; D015262:Xenobiotics / Q000378:metabolism
C513055:ABCB1 protein, human; C116614:ABCG2 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D000962:Antimalarials; D000970:Antineoplastic Agents; D005419:Flavonoids; D009125:Muscle Relaxants, Central; D009363:Neoplasm Proteins; D010880:Piperidines; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D015262:Xenobiotics; C077990:alvocidib; D008942:Mitoxantrone; D000069347:Erlotinib Hydrochloride; D003620:Dantrolene; D011802:Quinidine