Design and synthesis of 1,4-dihydropyridine derivatives as BACE-1 inhibitors.
Choi
Soo-Jeong
SJ
Department of Life Science, Gwangju Institute of Science and Technology, 1 Oryong-dong, Gwangju 500-712, Republic of Korea.
Cho
Joong-Heui
JH
Im
Isak
I
Lee
So-Deok
SD
Jang
Ji-Yeon
JY
Oh
Yu-Min
YM
Jung
Yong-Keun
YK
Jeon
Eun-Seok
ES
Kim
Yong-Chul
YC
D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D002460:Cell Line; D004095:Dihydropyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D015195:Drug Design; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D008968:Molecular Conformation
D004095:Dihydropyridines; C038806:1,4-dihydropyridine; D053829:Amyloid Precursor Protein Secretases; D016282:Aspartic Acid Endopeptidases; C509280:BACE1 protein, human