Trifluoromethyl-promoted homocamptothecins: synthesis and biological activity.
Zhu
Lingjian
L
School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, People's Republic of China.
Miao
Zhenyuan
Z
Sheng
Chunquan
C
Guo
Wei
W
Yao
Jianzhong
J
Liu
Wenfeng
W
Che
Xiaoying
X
Wang
Wenya
W
Cheng
Pengfei
P
Zhang
Wannian
W
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004264:DNA Topoisomerases, Type I / Q000378:metabolism; D054879:Halogenation; D006801:Humans; D008297:Male; D051379:Mice; D059004:Topoisomerase I Inhibitors
D000970:Antineoplastic Agents; D059004:Topoisomerase I Inhibitors; D004247:DNA; C120029:homocamptothecin; D004264:DNA Topoisomerases, Type I; D002166:Camptothecin