title: The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition.
authors.affiliation: Department of Pharmacy, National University of Singapore, 3 Science Drive 2, Block S15, no. 05-PI-03, Singapore 117543.
authors.forename: Siew Lee
authors.initials: SL
authors.lastname: Cheong
authors.forename: Anna
authors.initials: A
authors.lastname: Dolzhenko
authors.forename: Sonja
authors.initials: S
authors.lastname: Kachler
authors.forename: Silvia
authors.initials: S
authors.lastname: Paoletta
authors.forename: Stephanie
authors.initials: S
authors.lastname: Federico
authors.forename: Barbara
authors.initials: B
authors.lastname: Cacciari
authors.forename: Anton
authors.initials: A
authors.lastname: Dolzhenko
authors.forename: Karl-Norbert
authors.initials: KN
authors.lastname: Klotz
authors.forename: Stefano
authors.initials: S
authors.lastname: Moro
authors.forename: Giampiero
authors.initials: G
authors.lastname: Spalluto
authors.forename: Giorgia
authors.initials: G
authors.lastname: Pastorin
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D058916:Adenosine A1 Receptor Antagonists; D058917:Adenosine A2 Receptor Antagonists; D058918:Adenosine A3 Receptor Antagonists; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008958:Models, Molecular; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011869:Radioligand Assay; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000081:Acetamides; D058916:Adenosine A1 Receptor Antagonists; D058917:Adenosine A2 Receptor Antagonists; D058918:Adenosine A3 Receptor Antagonists; D005663:Furans; D006575:Heterocyclic Compounds, 3-Ring; C549347:N-(2-(phenyl)-8-methylpyrazolo(4,3-e)(1,2,4)triazolo(1,5-c)pyrimidin-5-yl)phenylacetamide; D011720:Pyrazoles; D011743:Pyrimidines; D014230:Triazoles; D000262:Adenylyl Cyclases