Assessing the trypanocidal potential of natural and semi-synthetic diketopiperazines from two deep water marine-derived fungi.
Watts
Katharine R
KR
Department of Chemistry and Biochemistry, University of California Santa Cruz, Santa Cruz, CA 95064, USA.
Ratnam
Joseline
J
Ang
Kean-Hooi
KH
Tenney
Karen
K
Compton
Jennifer E
JE
McKerrow
James
J
Crews
Phillip
P
D000107:Acetylation; D000818:Animals; D001232:Aspergillus fumigatus / Q000737:chemistry; D003546:Cysteine Endopeptidases / Q000737:chemistry; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology; D054659:Diketopiperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005658:Fungi / Q000737:chemistry*; D019015:Geologic Sediments / Q000737:chemistry; D006801:Humans; D007202:Indicators and Reagents; D019169:Jurkat Cells; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D010879:Piperazines / Q000737:chemistry; D013141:Spiro Compounds / Q000737:chemistry; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects
D015853:Cysteine Proteinase Inhibitors; D054659:Diketopiperazines; D007202:Indicators and Reagents; D010879:Piperazines; D013141:Spiro Compounds; D014344:Trypanocidal Agents; C478300:spirotryprostatin A; D003546:Cysteine Endopeptidases; C533458:TbcatB protein, Trypanosoma brucei; C446033:rhodesain