4,7-Dichloro benzothien-2-yl sulfonylaminomethyl boronic acid: first boronic acid-derived beta-lactamase inhibitor with class A, C, and D activity.
Tan
Qiang
Q
Department of Medicinal Chemistry, Merck & Co., Inc., Rahway, NJ 07065, USA. qiang_tan@merck.com
Ogawa
Aimie M
AM
Painter
Ronald E
RE
Park
Young-Whan
YW
Young
Katherine
K
DiNinno
Frank P
FP
D040981:Acinetobacter baumannii / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001897:Boronic Acids / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D065093:beta-Lactamase Inhibitors
D000900:Anti-Bacterial Agents; D001897:Boronic Acids; D004791:Enzyme Inhibitors; D065093:beta-Lactamase Inhibitors