Prediction of food effect by bile micelles on oral drug absorption considering free fraction in intestinal fluid.
Sugano
Kiyohiko
K
Global Research & Development, Sandwich Laboratories, Research Formulation, Pfizer Inc., CT13 9NJ Sandwich, Kent, UK. Kiyohiko.Sugano@pfizer.com <Kiyohiko.Sugano@pfizer.com>
Kataoka
Makoto
M
Mathews
Claudia da Costa
Cda C
Yamashita
Shinji
S
D000284:Administration, Oral; D000818:Animals; D001646:Bile / Q000737:chemistry / Q000378:metabolism*; D002463:Cell Membrane Permeability; D003613:Danazol; D005502:Food; D007408:Intestinal Absorption / Q000187:drug effects*; D008823:Micelles; D008954:Models, Biological; D010599:Pharmacokinetics; D011237:Predictive Value of Tests; D012995:Solubility
D008823:Micelles; D003613:Danazol