title: Cr(VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells.
authors.affiliation: Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, KY 40536-0305, USA.
authors.forename: Young-Ok
authors.initials: YO
authors.lastname: Son
authors.forename: J Andrew
authors.initials: JA
authors.lastname: Hitron
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Qingshan
authors.initials: Q
authors.lastname: Chang
authors.forename: Jingju
authors.initials: J
authors.lastname: Pan
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Zhang
authors.forename: Jiankang
authors.initials: J
authors.lastname: Liu
authors.forename: Shuxia
authors.initials: S
authors.lastname: Wang
authors.forename: Jeong-Chae
authors.initials: JC
authors.lastname: Lee
authors.forename: Xianglin
authors.initials: X
authors.lastname: Shi
mesh_terms: D000818:Animals; D017209:Apoptosis; D002274:Carcinogens, Environmental / Q000633:toxicity*; D020169:Caspases / Q000096:biosynthesis*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002857:Chromium / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
chemical_list: D002274:Carcinogens, Environmental; D017382:Reactive Oxygen Species; D016159:Tumor Suppressor Protein p53; D002857:Chromium; C074702:chromium hexavalent ion; D020169:Caspases