A 4-hydroxypyrrolidine-catalyzed mannich reaction of aldehydes: control of anti-selectivity by hydrogen bonding assisted by Brønsted acids.
Gómez-Bengoa
Enrique
E
Departmento de Química Orgánica I, Universidad del País Vasco, Manuel Lardizabal 3. 20018-San Sebastián, Spain.
Maestro
Miguel
M
Mielgo
Antonia
A
Otazo
Itziar
I
Palomo
Claudio
C
Velilla
Irene
I
D000143:Acids / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D000605:Amino Alcohols / Q000737:chemistry*; D002384:Catalysis; D006860:Hydrogen Bonding; D007097:Imines / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000737:chemistry*
C551484:4-hydroxypyrrolidine; D000143:Acids; D000447:Aldehydes; D000596:Amino Acids; D000605:Amino Alcohols; D007097:Imines; C482356:N-sulfonylimine; D011759:Pyrrolidines; D013450:Sulfones