Chromium dinicocysteinate supplementation can lower blood glucose, CRP, MCP-1, ICAM-1, creatinine, apparently mediated by elevated blood vitamin C and adiponectin and inhibition of NFkappaB, Akt, and Glut-2 in livers of zucker diabetic fatty rats.
Jain
Sushil K
SK
Department of Pediatrics, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA. sjain@lsuhsc.edu
Croad
Jennifer L
JL
Velusamy
Thirunavukkarasu
T
Rains
Justin L
JL
Bull
Rebeca
R
D052242:Adiponectin / Q000097:blood; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001205:Ascorbic Acid / Q000097:blood / Q000378:metabolism; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D002460:Cell Line; D002857:Chromium / Q000008:administration & dosage* / Q000097:blood; D056831:Coordination Complexes / Q000008:administration & dosage*; D003545:Cysteine / Q000008:administration & dosage* / Q000031:analogs & derivatives; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000178:diet therapy* / Q000378:metabolism; D003925:Diabetic Angiopathies / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control*; D003928:Diabetic Nephropathies / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control*; D019587:Dietary Supplements; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009000:Monocytes / Q000378:metabolism; D009942:Organometallic Compounds / Q000008:administration & dosage; D018384:Oxidative Stress / Q000187:drug effects; D011897:Random Allocation; D051381:Rats; D011924:Rats, Zucker; D015398:Signal Transduction
D052242:Adiponectin; D000894:Anti-Inflammatory Agents, Non-Steroidal; D015415:Biomarkers; D056831:Coordination Complexes; D007004:Hypoglycemic Agents; D009942:Organometallic Compounds; C555349:chromium dinicocysteinate; D002857:Chromium; D003545:Cysteine; D001205:Ascorbic Acid