title: Impact of different carbapenems and regimens of administration on resistance emergence for three isogenic Pseudomonas aeruginosa strains with differing mechanisms of resistance.
authors.affiliation: Ordway Research Institute, Albany, NY 12208, USA.
authors.forename: Arnold
authors.initials: A
authors.lastname: Louie
authors.forename: Adam
authors.initials: A
authors.lastname: Bied
authors.forename: Christine
authors.initials: C
authors.lastname: Fregeau
authors.forename: Brian
authors.initials: B
authors.lastname: Van Scoy
authors.forename: David
authors.initials: D
authors.lastname: Brown
authors.forename: Weiguo
authors.initials: W
authors.lastname: Liu
authors.forename: Karen
authors.initials: K
authors.lastname: Bush
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Queenan
authors.forename: Brian
authors.initials: B
authors.lastname: Morrow
authors.forename: Mohammed
authors.initials: M
authors.lastname: Khashab
authors.forename: James B
authors.initials: JB
authors.lastname: Kahn
authors.forename: Susan
authors.initials: S
authors.lastname: Nicholson
authors.forename: Robert
authors.initials: R
authors.lastname: Kulawy
authors.forename: G L
authors.initials: GL
authors.lastname: Drusano
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001426:Bacterial Proteins / Q000235:genetics; D015780:Carbapenems / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000077726:Doripenem; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005798:Genes, Bacterial; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D009154:Mutation; D018272:Porins / Q000235:genetics; D016016:Proportional Hazards Models; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D013997:Time Factors; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D015780:Carbapenems; D018272:Porins; C077157:OprD protein, Pseudomonas aeruginosa; D015378:Imipenem; D000077726:Doripenem; C048795:AmpC beta-lactamases; D001618:beta-Lactamases