title: Antagonism of the complement component C4 by flavivirus nonstructural protein NS1.
authors.affiliation: Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
authors.forename: Panisadee
authors.initials: P
authors.lastname: Avirutnan
authors.forename: Anja
authors.initials: A
authors.lastname: Fuchs
authors.forename: Richard E
authors.initials: RE
authors.lastname: Hauhart
authors.forename: Pawit
authors.initials: P
authors.lastname: Somnuke
authors.forename: Soonjeon
authors.initials: S
authors.lastname: Youn
authors.forename: Michael S
authors.initials: MS
authors.lastname: Diamond
authors.forename: John P
authors.initials: JP
authors.lastname: Atkinson
mesh_terms: D000818:Animals; D055162:Biocatalysis / Q000187:drug effects; D016466:CHO Cells; D003172:Complement C1 / Q000378:metabolism; D050718:Complement C1 Inhibitor Protein / Q000378:metabolism; D003173:Complement C1s / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism; D050577:Complement C3-C5 Convertases / Q000378:metabolism; D003179:Complement C3b / Q000378:metabolism; D003181:Complement C4 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015935:Complement C4b / Q000378:metabolism; D017244:Complement Factor I / Q000378:metabolism; D015941:Complement Hemolytic Activity Assay; D003171:Complement Pathway, Classical / Q000187:drug effects / Q000276:immunology; D037582:Complement Pathway, Mannose-Binding Lectin / Q000187:drug effects / Q000276:immunology; D006224:Cricetinae; D003412:Cricetulus; D003716:Dengue Virus / Q000276:immunology; D004792:Enzyme Precursors / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D007700:Kinetics; D009500:Neutralization Tests; D011485:Protein Binding / Q000276:immunology; D017361:Viral Nonstructural Proteins / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D003172:Complement C1; D050718:Complement C1 Inhibitor Protein; D003181:Complement C4; D004792:Enzyme Precursors; C079340:NS1 protein, Dengue virus type 2; C100315:NS1 protein, Flavivirus; D017361:Viral Nonstructural Proteins; C531936:nonstructural protein 1, West Nile virus; D003179:Complement C3b; D015935:Complement C4b; D050577:Complement C3-C5 Convertases; D003173:Complement C1s; D017244:Complement Factor I