title: Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists.
authors.affiliation: Argenta, 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex, UK. Sue.cramp@argentadiscovery.com
authors.forename: Sue
authors.initials: S
authors.lastname: Cramp
authors.forename: Hazel J
authors.initials: HJ
authors.lastname: Dyke
authors.forename: Christopher
authors.initials: C
authors.lastname: Higgs
authors.forename: David E
authors.initials: DE
authors.lastname: Clark
authors.forename: Matthew
authors.initials: M
authors.lastname: Gill
authors.forename: Pascal
authors.initials: P
authors.lastname: Savy
authors.forename: Neil
authors.initials: N
authors.lastname: Jennings
authors.forename: Steve
authors.initials: S
authors.lastname: Price
authors.forename: Peter M
authors.initials: PM
authors.lastname: Lockey
authors.forename: Dennis
authors.initials: D
authors.lastname: Norman
authors.forename: Soraya
authors.initials: S
authors.lastname: Porres
authors.forename: Francis
authors.initials: F
authors.lastname: Wilson
authors.forename: Alison
authors.initials: A
authors.lastname: Jones
authors.forename: Nigel
authors.initials: N
authors.lastname: Ramsden
authors.forename: Raffaella
authors.initials: R
authors.lastname: Mangano
authors.forename: Dan
authors.initials: D
authors.lastname: Leggate
authors.forename: Marie
authors.initials: M
authors.lastname: Andersson
authors.forename: Richard
authors.initials: R
authors.lastname: Hale
mesh_terms: D000818:Animals; D001682:Biological Availability; D055808:Drug Discovery; D006633:Histamine Antagonists / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008252:Macaca fascicularis; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors*; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4; D013237:Stereoisomerism
chemical_list: D006633:Histamine Antagonists; C498828:Hrh4 protein, rat; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4