title: Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex.
authors.affiliation: Molecular Neuroscience Research Center, Shiga University of Medical Science, Shiga 520-2192, Japan.
authors.forename: Yachiyo
authors.initials: Y
authors.lastname: Mitsuishi
authors.affiliation: Molecular Neuroscience Research Center, Shiga University of Medical Science, Shiga 520-2192, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hasegawa
authors.affiliation: Molecular Neuroscience Research Center, Shiga University of Medical Science, Shiga 520-2192, Japan.
authors.forename: Akinori
authors.initials: A
authors.lastname: Matsuo
authors.affiliation: Department of Demyelinating Disease and Aging, National Institute of Neuroscience, NCNP, Tokyo 187-8502, Japan.
authors.forename: Wataru
authors.initials: W
authors.lastname: Araki
authors.affiliation: Laboratory of Neuroscience, Graduate School of Pharmaceutical Sciences, Hokkaido University, Hokkaido 060-0812, Japan.
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Department of Post-Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Tagami
authors.affiliation: Department of Post-Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
authors.forename: Masayasu
authors.initials: M
authors.lastname: Okochi
authors.affiliation: Department of Post-Genomics and Diseases, Division of Psychiatry and Behavioral Proteomics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Takeda
authors.affiliation: Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen 6500 HB, The Netherlands.
authors.forename: Ronald
authors.initials: R
authors.lastname: Roepman
authors.affiliation: Molecular Neuroscience Research Center, Shiga University of Medical Science, Shiga 520-2192, Japan. Electronic address: mnishimu@belle.shiga-med.ac.jp.
authors.forename: Masaki
authors.initials: M
authors.lastname: Nishimura
mesh_terms: D053829:Amyloid Precursor Protein Secretases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D001483:Base Sequence; D002352:Carrier Proteins / Q000502:physiology*; D002460:Cell Line; D010450:Endopeptidases; D006801:Humans; D006868:Hydrolysis; D008565:Membrane Proteins / Q000378:metabolism* / Q000502:physiology*; D010447:Peptide Hydrolases; D053764:Presenilin-1 / Q000378:metabolism*; D011485:Protein Binding; D034622:RNA Interference; D034741:RNA, Small Interfering
chemical_list: D016564:Amyloid beta-Protein Precursor; C492531:CRB2 protein, human; D002352:Carrier Proteins; D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1; D034741:RNA, Small Interfering; C475154:APH1A protein, human; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D010447:Peptide Hydrolases