Proleukemic RUNX1 and CBFbeta mutations in the pathogenesis of acute leukemia.
Engel
Michael E
ME
Department of Pediatrics, Monroe Carell Jr. Children's Hospital, Nashville, TN, USA. mike.engel@vanderbilt.edu
Hiebert
Scott W
SW
D002471:Cell Transformation, Neoplastic / Q000235:genetics; D050676:Core Binding Factor Alpha 2 Subunit / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D050658:Core Binding Factor beta Subunit / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D015973:Gene Expression Regulation, Leukemic / Q000235:genetics*; D006410:Hematopoiesis; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000473:pathology; D009154:Mutation; D009363:Neoplasm Proteins / Q000737:chemistry / Q000235:genetics* / Q000502:physiology; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000502:physiology*; D014158:Transcription, Genetic; D014178:Translocation, Genetic
D050676:Core Binding Factor Alpha 2 Subunit; D050658:Core Binding Factor beta Subunit; D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; C493728:RUNX1 protein, human