High-throughput analysis of in vitro cytochrome p450 inhibition samples using mass spectrometry coupled with an integrated liquid chromatography/autosampler system.
Brown
Ann
A
Bickford
Shari
S
Hatsis
Panos
P
Amin
Jakal
J
Bell
Leslie
L
Harriman
Shawn
S
D057205:Automation, Laboratory / Q000379:methods; D002853:Chromatography, Liquid / Q000379:methods; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry; D055808:Drug Discovery / Q000379:methods*; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D057166:High-Throughput Screening Assays / Q000379:methods*; D016014:Linear Models; D013058:Mass Spectrometry / Q000379:methods*; D008874:Midazolam / Q000031:analogs & derivatives / Q000737:chemistry
D065607:Cytochrome P-450 Enzyme Inhibitors; D004791:Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System; C040081:1-hydroxymethylmidazolam; D008874:Midazolam