Two-layered dissolving microneedles for percutaneous delivery of peptide/protein drugs in rats.
Fukushima
Keizo
K
Department of Pharmacokinetics, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto, 607-8412, Japan. keizo@mb.kyoto-phu.ac.jp
Ise
Ayaka
A
Morita
Hiromi
H
Hasegawa
Ryo
R
Ito
Yukako
Y
Sugioka
Nobuyuki
N
Takada
Kanji
K
D000279:Administration, Cutaneous; D000818:Animals; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D003911:Dextrans / Q000737:chemistry; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004355:Drug Stability; D005240:Feasibility Studies; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives / Q000737:chemistry; D019382:Human Growth Hormone / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D008297:Male; D008845:Microinjections / Q000295:instrumentation* / Q000379:methods; D018715:Microscopy, Video; D009339:Needles; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D012869:Skin Absorption; D012995:Solubility
D003911:Dextrans; D011994:Recombinant Proteins; C015219:fluorescein isothiocyanate dextran; D019382:Human Growth Hormone; D003894:Deamino Arginine Vasopressin; D016650:Fluorescein-5-isothiocyanate