Apoptosis in leukemias: regulation and therapeutic targeting.
Samudio
Ismael
I
Department of Stem Cell Transplantation and Cellular Therapy, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. mandreef@mdanderson.org
Konopleva
Marina
M
Carter
Bing
B
Andreeff
Michael
M
D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D051017:Apoptosis Regulatory Proteins / Q000235:genetics / Q000502:physiology*; D020169:Caspases / Q000502:physiology; D015853:Cysteine Proteinase Inhibitors / Q000502:physiology / Q000627:therapeutic use; D004273:DNA, Neoplasm / Q000235:genetics; D016503:Drug Delivery Systems; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D009363:Neoplasm Proteins / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D051736:Proto-Oncogene Proteins c-mdm2 / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000502:physiology; D016159:Tumor Suppressor Protein p53 / Q000502:physiology; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000502:physiology
D000970:Antineoplastic Agents; D051017:Apoptosis Regulatory Proteins; D015853:Cysteine Proteinase Inhibitors; D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D053221:TNF-Related Apoptosis-Inducing Ligand; D016159:Tumor Suppressor Protein p53; D051636:X-Linked Inhibitor of Apoptosis Protein; D051736:Proto-Oncogene Proteins c-mdm2; D020169:Caspases