Histidine residue mediates radical-induced hinge cleavage of human IgG1.
Yates
Zac
Z
Department of Analytical and Formulation Science, Amgen Inc., Seattle, Washington 98119, USA.
Gunasekaran
Kannan
K
Zhou
Hongxing
H
Hu
Zhonghua
Z
Liu
Zhi
Z
Ketchem
Randal R
RR
Yan
Boxu
B
D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal / Q000737:chemistry; D053148:Caspase 3 / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003545:Cysteine / Q000737:chemistry; D019075:Electrophoresis, Capillary; D005609:Free Radicals; D006639:Histidine / Q000737:chemistry*; D006801:Humans; D006860:Hydrogen Bonding; D007074:Immunoglobulin G / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D010100:Oxygen / Q000737:chemistry; D011522:Protons
D000911:Antibodies, Monoclonal; D005609:Free Radicals; D007074:Immunoglobulin G; D011522:Protons; D006639:Histidine; D053148:Caspase 3; D003545:Cysteine; D010100:Oxygen