Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase.
Brown
Kristy A
KA
Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, VIC, 3168, Australia. Kristy.Brown@princehenrys.org
Hunger
Nicole I
NI
Docanto
Maria
M
Simpson
Evan R
ER
D000091162:AMP-Activated Protein Kinase Kinases; D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D021581:Active Transport, Cell Nucleus; D000273:Adipose Tissue / Q000187:drug effects* / Q000201:enzymology; D000818:Animals; D001141:Aromatase / Q000235:genetics / Q000378:metabolism*; D047072:Aromatase Inhibitors / Q000494:pharmacology*; D001665:Binding Sites; D001940:Breast / Q000187:drug effects* / Q000201:enzymology; D019556:COS Cells; D002522:Chlorocebus aethiops; D005576:Colforsin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation; D005260:Female; D006801:Humans; D008687:Metformin / Q000494:pharmacology*; D010766:Phosphorylation; D011401:Promoter Regions, Genetic; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D017154:Stromal Cells / Q000187:drug effects* / Q000201:enzymology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013912:Threonine; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014162:Transfection
D047072:Aromatase Inhibitors; C493245:CRTC2 protein, human; D014157:Transcription Factors; D005576:Colforsin; D013912:Threonine; D008687:Metformin; D001141:Aromatase; D017346:Protein Serine-Threonine Kinases; C109790:STK11 protein, human; D000091162:AMP-Activated Protein Kinase Kinases; D055372:AMP-Activated Protein Kinases; D013755:Tetradecanoylphorbol Acetate