Tumor promotion by copper-overloading and its enhancement by excess iron accumulation involving oxidative stress responses in the early stage of a rat two-stage hepatocarcinogenesis model.
Mizukami
Sayaka
S
Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan.
Ichimura
Ryohei
R
Kemmochi
Sayaka
S
Wang
Liyun
L
Taniai
Eriko
E
Mitsumori
Kunitoshi
K
Shibutani
Makoto
M
D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity; D003300:Copper / Q000378:metabolism*; D004052:Diethylnitrosamine / Q000633:toxicity; D005982:Glutathione Transferase / Q000378:metabolism; D007150:Immunohistochemistry; D007501:Iron / Q000378:metabolism*; D019190:Iron Overload / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology; D008297:Male; D018384:Oxidative Stress; D051381:Rats; D011916:Rats, Inbred F344; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis / Q000378:metabolism; D013997:Time Factors
D002273:Carcinogens; D017392:Thiobarbituric Acid Reactive Substances; D004052:Diethylnitrosamine; D003300:Copper; D007501:Iron; D005982:Glutathione Transferase