Inhibition of mTORC1 signaling reduces tumor growth but does not prevent cancer progression in a mouse model of thyroid cancer.
Guigon
Celine J
CJ
Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4264, USA.
Fozzatti
Laura
L
Lu
Changxue
C
Willingham
Mark C
MC
Cheng
Sheue-Yann
SY
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle; D004195:Disease Models, Animal; D018450:Disease Progression; D000068338:Everolimus; D048049:Extracellular Signal-Regulated MAP Kinases / Q000502:physiology; D000076222:Mechanistic Target of Rapamycin Complex 1; D051379:Mice; D046912:Multiprotein Complexes; D051059:PTEN Phosphohydrolase / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D011506:Proteins; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology; D019893:Ribosomal Protein S6 Kinases / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects*; D020123:Sirolimus / Q000031:analogs & derivatives / Q000494:pharmacology; D058570:TOR Serine-Threonine Kinases; D037042:Thyroid Hormone Receptors beta / Q000235:genetics; D013964:Thyroid Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000517:prevention & control; D014157:Transcription Factors / Q000037:antagonists & inhibitors* / Q000502:physiology
D000068338:Everolimus; D048049:Extracellular Signal-Regulated MAP Kinases; D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes; D051059:PTEN Phosphohydrolase; D019869:Phosphatidylinositol 3-Kinases; D011506:Proteins; D051057:Proto-Oncogene Proteins c-akt; D019893:Ribosomal Protein S6 Kinases; D020123:Sirolimus; D058570:TOR Serine-Threonine Kinases; D037042:Thyroid Hormone Receptors beta; D014157:Transcription Factors; C487757:Pten protein, mouse