title: The introduction of P4 substituted 1-methylcyclohexyl groups into Boceprevir: a change in direction in the search for a second generation HCV NS3 protease inhibitor.
authors.affiliation: Schering-Plough Research Institute, K-15-A-3545, Kenilworth, NJ 07033, USA. frank.bennett@spcorp.com
authors.forename: Frank
authors.initials: F
authors.lastname: Bennett
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Huang
authors.forename: Siska
authors.initials: S
authors.lastname: Hendrata
authors.forename: Raymond
authors.initials: R
authors.lastname: Lovey
authors.forename: Stephane L
authors.initials: SL
authors.lastname: Bogen
authors.forename: Weidong
authors.initials: W
authors.lastname: Pan
authors.forename: Zhuyan
authors.initials: Z
authors.lastname: Guo
authors.forename: Andrew
authors.initials: A
authors.lastname: Prongay
authors.forename: Kevin X
authors.initials: KX
authors.lastname: Chen
authors.forename: Ashok
authors.initials: A
authors.lastname: Arasappan
authors.forename: Srikanth
authors.initials: S
authors.lastname: Venkatraman
authors.forename: Francisco
authors.initials: F
authors.lastname: Velazquez
authors.forename: Latha
authors.initials: L
authors.lastname: Nair
authors.forename: Mousumi
authors.initials: M
authors.lastname: Sannigrahi
authors.forename: Xiao
authors.initials: X
authors.lastname: Tong
authors.forename: John
authors.initials: J
authors.lastname: Pichardo
authors.forename: Kuo-Chi
authors.initials: KC
authors.lastname: Cheng
authors.forename: Viyyoor M
authors.initials: VM
authors.lastname: Girijavallabhan
authors.forename: Anil K
authors.initials: AK
authors.lastname: Saksena
authors.forename: F George
authors.initials: FG
authors.lastname: Njoroge
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D019540:Area Under Curve; D001682:Biological Availability; D018360:Crystallography, X-Ray; D000882:Haplorhini; D008958:Models, Molecular; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D011480:Protease Inhibitors / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
chemical_list: D000998:Antiviral Agents; D011392:Proline; D011480:Protease Inhibitors; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases; C512204:N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide