Characterization of a monoclonal antibody cell culture production process using a quality by design approach.
Horvath
Brian
B
Late Stage Cell Culture, BioProcess Development US, Genentech-a member of the Roche Group, San Francisco, CA, USA. horvath.brian@gene.com
Mun
Melissa
M
Laird
Michael W
MW
D000143:Acids; D000704:Analysis of Variance; D000818:Animals; D000911:Antibodies, Monoclonal / Q000096:biosynthesis*; D019149:Bioreactors; D016466:CHO Cells; D018929:Cell Culture Techniques / Q000379:methods*; D002852:Chromatography, Ion Exchange; D006224:Cricetinae; D003412:Cricetulus; D003470:Culture Media; D006863:Hydrogen-Ion Concentration; D015203:Reproducibility of Results; D012107:Research Design; D013696:Temperature
D000143:Acids; D000911:Antibodies, Monoclonal; D003470:Culture Media