Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway.
Cao
Risheng
R
Departments of Microbiology and Immunology, Virginia Commonwealth University, Richmond, VA 23298, USA.
Cronk
Zhumei Xu
ZX
Zha
Weibin
W
Sun
Lixin
L
Wang
Xuan
X
Fang
Youwen
Y
Studer
Elaine
E
Zhou
Huiping
H
Pandak
William M
WM
Dent
Paul
P
Gil
Gregorio
G
Hylemon
Phillip B
PB
D000818:Animals; D002262:Carboxy-Lyases / Q000235:genetics; D015536:Down-Regulation / Q000187:drug effects; D005402:Fistula / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D005943:Gluconeogenesis / Q000187:drug effects / Q000235:genetics*; D005952:Glucose-6-Phosphatase / Q000235:genetics; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D007328:Insulin / Q000378:metabolism; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D008297:Male; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D000081382:Pyruvate Dehydrogenase Acetyl-Transferring Kinase; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction / Q000187:drug effects*; D013656:Taurocholic Acid / Q000494:pharmacology*; D000099150:Receptor, Farnesoid X-Activated
D002262:Carboxy-Lyases; D005952:Glucose-6-Phosphatase; D007328:Insulin; D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases; D051057:Proto-Oncogene Proteins c-akt; D000081382:Pyruvate Dehydrogenase Acetyl-Transferring Kinase; D012333:RNA, Messenger; D018160:Receptors, Cytoplasmic and Nuclear; D043562:Receptors, G-Protein-Coupled; D013656:Taurocholic Acid; D000099150:Receptor, Farnesoid X-Activated; C099713:nuclear receptor subfamily 0, group B, member 2