Antagonism of the complement component C4 by flavivirus nonstructural protein NS1.
Avirutnan
Panisadee
P
Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.
Fuchs
Anja
A
Hauhart
Richard E
RE
Somnuke
Pawit
P
Youn
Soonjeon
S
Diamond
Michael S
MS
Atkinson
John P
JP
D000818:Animals; D055162:Biocatalysis / Q000187:drug effects; D016466:CHO Cells; D003172:Complement C1 / Q000378:metabolism; D050718:Complement C1 Inhibitor Protein / Q000378:metabolism; D003173:Complement C1s / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism; D050577:Complement C3-C5 Convertases / Q000378:metabolism; D003179:Complement C3b / Q000378:metabolism; D003181:Complement C4 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015935:Complement C4b / Q000378:metabolism; D017244:Complement Factor I / Q000378:metabolism; D015941:Complement Hemolytic Activity Assay; D003171:Complement Pathway, Classical / Q000187:drug effects / Q000276:immunology; D037582:Complement Pathway, Mannose-Binding Lectin / Q000187:drug effects / Q000276:immunology; D006224:Cricetinae; D003412:Cricetulus; D003716:Dengue Virus / Q000276:immunology; D004792:Enzyme Precursors / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D007700:Kinetics; D009500:Neutralization Tests; D011485:Protein Binding / Q000276:immunology; D017361:Viral Nonstructural Proteins / Q000378:metabolism* / Q000494:pharmacology
D003172:Complement C1; D050718:Complement C1 Inhibitor Protein; D003181:Complement C4; D004792:Enzyme Precursors; C079340:NS1 protein, Dengue virus type 2; C100315:NS1 protein, Flavivirus; D017361:Viral Nonstructural Proteins; C531936:nonstructural protein 1, West Nile virus; D003179:Complement C3b; D015935:Complement C4b; D050577:Complement C3-C5 Convertases; D003173:Complement C1s; D017244:Complement Factor I