title: Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity and of Ras farnesylation mediate antitumor effects of anandamide in human breast cancer cells.
authors.affiliation: Institute of Endocrinology e Experimental Oncology, CNR, Via Pansini 5, 80131 Naples, Italy. chilaez@libero.it
authors.forename: Chiara
authors.initials: C
authors.lastname: Laezza
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Malfitano
authors.forename: Maria Chiara
authors.initials: MC
authors.lastname: Proto
authors.forename: Iolanda
authors.initials: I
authors.lastname: Esposito
authors.forename: Patrizia
authors.initials: P
authors.lastname: Gazzerro
authors.forename: Pietro
authors.initials: P
authors.lastname: Formisano
authors.forename: Simona
authors.initials: S
authors.lastname: Pisanti
authors.forename: Antonietta
authors.initials: A
authors.lastname: Santoro
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Caruso
authors.forename: Maurizio
authors.initials: M
authors.lastname: Bifulco
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors*; D000970:Antineoplastic Agents / Q000494:pharmacology; D001095:Arachidonic Acids / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D063385:Cannabinoid Receptor Modulators / Q000494:pharmacology; D002277:Carcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D015536:Down-Regulation / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D063388:Endocannabinoids; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005260:Female; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics / Q000378:metabolism; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides / Q000494:pharmacology*; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: C551918:2-methyl-2'-F-anandamide; D000970:Antineoplastic Agents; D001095:Arachidonic Acids; D063385:Cannabinoid Receptor Modulators; D063388:Endocannabinoids; D004791:Enzyme Inhibitors; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D053284:Polyunsaturated Alkamides; D006903:Hydroxymethylglutaryl CoA Reductases; D019883:Alkyl and Aryl Transferases; C083291:geranylgeranyltransferase type-I; D018631:ras Proteins; C078814:anandamide