Inhibition of mitochondrial division through covalent modification of Drp1 protein by 15 deoxy-Delta(12,14)-prostaglandin J2.
Mishra
Nandita
N
Department of Pathology, UT Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Kar
Rekha
R
Singha
Prajjal K
PK
Venkatachalam
Manjeri A
MA
McEwen
Donald G
DG
Saikumar
Pothana
P
D000818:Animals; D002460:Cell Line; D003545:Cysteine / Q000235:genetics; D034281:Dynamins / Q000235:genetics / Q000378:metabolism; D020558:GTP Phosphohydrolases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000235:genetics / Q000378:metabolism*; D008928:Mitochondria / Q000187:drug effects* / Q000502:physiology; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D015230:Prostaglandin D2 / Q000031:analogs & derivatives* / Q000494:pharmacology; D017434:Protein Structure, Tertiary / Q000235:genetics; D051381:Rats
C097240:15-deoxy-delta(12,14)-prostaglandin J2; D008869:Microtubule-Associated Proteins; D024101:Mitochondrial Proteins; D020558:GTP Phosphohydrolases; C110768:DNM1L protein, human; C519851:Dnm1l protein, rat; D034281:Dynamins; D003545:Cysteine; D015230:Prostaglandin D2