Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test.
Kalinichev
Mikhail
M
Department of Biology, Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline plc, New Frontiers Science Park, Third Ave., Harlow, Essex CM19 5AW, UK.
Starr
Kathryn R
KR
Teague
Simon
S
Bradford
Andrea M
AM
Porter
Rod A
RA
Herdon
Hugh J
HJ
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D004597:Electroshock; D005998:Glycine / Q000378:metabolism*; D050487:Glycine Plasma Membrane Transport Proteins / Q000037:antagonists & inhibitors*; D008297:Male; D010636:Phenols / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000378:metabolism* / Q000503:physiopathology
C438943:2-(N-bis(2-methoxyethyl)amino)butyric acid,2',6'-dimethoxyphenyl ester hydrobromide; D000927:Anticonvulsants; D001549:Benzamides; C561922:GSK 931145; D050487:Glycine Plasma Membrane Transport Proteins; D010636:Phenols; C493266:Slc6a9 protein, rat; D005998:Glycine