title: A novel microtubule-modulating agent induces mitochondrially driven caspase-dependent apoptosis via mitotic checkpoint activation in human prostate cancer cells.
authors.affiliation: Department of Biology, Georgia State University, Atlanta, GA 30303, USA. raneja@gsu.edu
authors.forename: Ritu
authors.initials: R
authors.lastname: Aneja
authors.forename: Tohru
authors.initials: T
authors.lastname: Miyagi
authors.forename: Prasanthi
authors.initials: P
authors.lastname: Karna
authors.forename: Tucker
authors.initials: T
authors.lastname: Ezell
authors.forename: Deep
authors.initials: D
authors.lastname: Shukla
authors.forename: Meenakshi
authors.initials: M
authors.lastname: Vij Gupta
authors.forename: Clayton
authors.initials: C
authors.lastname: Yates
authors.forename: Sreenivasa R
authors.initials: SR
authors.lastname: Chinni
authors.forename: Haiyen
authors.initials: H
authors.lastname: Zhau
authors.forename: Leland W K
authors.initials: LW
authors.lastname: Chung
authors.forename: Harish C
authors.initials: HC
authors.lastname: Joshi
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000502:physiology; D053148:Caspase 3 / Q000378:metabolism*; D045744:Cell Line, Tumor; D004149:Dioxoles / Q000494:pharmacology*; D016195:G2 Phase / Q000187:drug effects; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D008928:Mitochondria / Q000201:enzymology*; D008938:Mitosis / Q000187:drug effects; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D050257:Tubulin Modulators / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays / Q000379:methods
chemical_list: D004149:Dioxoles; C510553:EM011 compound; D007546:Isoquinolines; D050257:Tubulin Modulators; D053148:Caspase 3