Genetically engineered mannosylated-human serum albumin as a versatile carrier for liver-selective therapeutics.
Hirata
Kenshiro
K
Department of Biopharmaceutics, Kumamoto University, Japan.
Maruyama
Toru
T
Watanabe
Hiroshi
H
Maeda
Hitoshi
H
Nakajou
Keisuke
K
Iwao
Yasunori
Y
Ishima
Yu
Y
Katsumi
Hidemasa
H
Hashida
Mitsuru
M
Otagiri
Masaki
M
D000818:Animals; D015153:Blotting, Western; D002942:Circular Dichroism; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000737:chemistry* / Q000493:pharmacokinetics; D004591:Electrophoresis, Polyacrylamide Gel; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D051547:Heme Oxygenase-1 / Q000378:metabolism; D006801:Humans; D007728:Kupffer Cells / Q000187:drug effects / Q000378:metabolism; D037181:Lectins, C-Type / Q000378:metabolism*; D008099:Liver / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D008358:Mannose / Q000737:chemistry / Q000235:genetics* / Q000493:pharmacokinetics; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics* / Q000493:pharmacokinetics; D015427:Reperfusion Injury / Q000188:drug therapy / Q000378:metabolism; D012709:Serum Albumin / Q000737:chemistry / Q000235:genetics* / Q000493:pharmacokinetics; D014018:Tissue Distribution
D004337:Drug Carriers; D037181:Lectins, C-Type; D000090323:Mannose Receptor; D037241:Mannose-Binding Lectins; D017382:Reactive Oxygen Species; D011956:Receptors, Cell Surface; D011994:Recombinant Proteins; D012709:Serum Albumin; C023840:mannose-bovine serum albumin conjugate; D009569:Nitric Oxide; D051547:Heme Oxygenase-1; D008358:Mannose