Use of glucuronidation fingerprinting to describe and predict mono- and dihydroxyflavone metabolism by recombinant UGT isoforms and human intestinal and liver microsomes.
Tang
Lan
L
Department of Pharmaceutics, School of Pharmaceutical Sciences, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou, Guangdong 510515, China.
Ye
Ling
L
Singh
Rashim
R
Wu
Baojian
B
Lv
Chang
C
Zhao
Jie
J
Liu
Zhongqiu
Z
Hu
Ming
M
D002853:Chromatography, Liquid; D047309:Flavones / Q000378:metabolism*; D014453:Glucuronosyltransferase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism*; D008861:Microsomes / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism*; D053719:Tandem Mass Spectrometry; D000090264:UDP-Glucuronosyltransferase 1A9; D000099148:UGT1A1 Enzyme
D047309:Flavones; D014453:Glucuronosyltransferase; D007527:Isoenzymes; D011994:Recombinant Proteins; D000090264:UDP-Glucuronosyltransferase 1A9; D000099148:UGT1A1 Enzyme; C000715591:UGT1A9 protein, human; C491474:UGT2B7 protein, human; C476725:bilirubin uridine-diphosphoglucuronosyl transferase 1A10; C454320:UDP-glucuronosyltransferase, UGT1A8; C524630:UGT1A7 protein, human