Idd9.2 and Idd9.3 protective alleles function in CD4+ T-cells and nonlymphoid cells to prevent expansion of pathogenic islet-specific CD8+ T-cells.
Hamilton-Williams
Emma E
EE
Department of Immunology and Microbial Sciences, The Scripps Research Institute, La Jolla, California, USA.
Wong
S B Justin
SB
Martinez
Xavier
X
Rainbow
Daniel B
DB
Hunter
Kara M
KM
Wicker
Linda S
LS
Sherman
Linda A
LA
D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology*; D005434:Flow Cytometry; D005786:Gene Expression Regulation; D020022:Genetic Predisposition to Disease; D005952:Glucose-6-Phosphatase / Q000235:genetics; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology* / Q000503:physiopathology; D051379:Mice; D016688:Mice, Inbred NOD; D011506:Proteins / Q000235:genetics
D011506:Proteins; D005952:Glucose-6-Phosphatase; C117983:G6pc2 protein, mouse