title: Hepatic CYP2B6 is altered by genetic, physiologic, and environmental factors but plays little role in nicotine metabolism.
authors.affiliation: Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
authors.forename: N
authors.initials: N
authors.lastname: Al Koudsi
authors.forename: R F
authors.initials: RF
authors.lastname: Tyndale
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics / Q000378:metabolism*; D065702:Cytochrome P-450 CYP2B6; D005260:Female; D005838:Genotype; D006801:Humans; D016014:Linear Models; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009538:Nicotine / Q000378:metabolism*; D010084:Oxidation-Reduction; D010089:Oxidoreductases, N-Demethylating / Q000235:genetics / Q000378:metabolism*; D012737:Sex Factors; D055815:Young Adult
chemical_list: D009538:Nicotine; D001189:Aryl Hydrocarbon Hydroxylases; C585599:CYP2B6 protein, human; D065702:Cytochrome P-450 CYP2B6; D010089:Oxidoreductases, N-Demethylating