Tyrosine phosphorylation of SHIP promotes its proteasomal degradation.
Ruschmann
Jens
J
The Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, BC, Canada.
Ho
Victor
V
Antignano
Frann
F
Kuroda
Etsushi
E
Lam
Vivian
V
Ibaraki
Mariko
M
Snyder
Kim
K
Kim
Connie
C
Flavell
Richard A
RA
Kawakami
Toshiaki
T
Sly
Laura
L
Turhan
Ali G
AG
Krystal
Gerald
G
D000818:Animals; D002460:Cell Line / Q000378:metabolism; D003433:Crosses, Genetic; D015536:Down-Regulation; D004318:Doxycycline / Q000494:pharmacology; D016044:Fusion Proteins, bcr-abl / Q000502:physiology*; D006801:Humans; D000072181:Inositol Polyphosphate 5-Phosphatases; D007377:Interleukin-3 / Q000494:pharmacology; D015847:Interleukin-4 / Q000494:pharmacology; D008214:Lymphocytes / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000378:metabolism; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism*; D010766:Phosphorylation; D019000:Phosphotyrosine / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D011993:Recombinant Fusion Proteins / Q000502:physiology; D013047:Specific Pathogen-Free Organisms; D019061:src-Family Kinases / Q000172:deficiency / Q000502:physiology
D007377:Interleukin-3; D011993:Recombinant Fusion Proteins; D015847:Interleukin-4; D019000:Phosphotyrosine; D016044:Fusion Proteins, bcr-abl; D019061:src-Family Kinases; D010744:Phosphoric Monoester Hydrolases; D000072181:Inositol Polyphosphate 5-Phosphatases; D051059:PTEN Phosphohydrolase; C487757:Pten protein, mouse; C000606430:INPP5D protein, human; C000606433:Inpp5d protein, mouse; C000606435:Inppl1 protein, mouse; D000072183:Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases; D046988:Proteasome Endopeptidase Complex; D004318:Doxycycline