KMUP-1 ameliorates monocrotaline-induced pulmonary arterial hypertension through the modulation of Ca2+ sensitization and K+-channel.
Dai
Zen-Kong
ZK
Department of Pediatrics, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Division of Pediatric Pulmonology and Cardiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Cheng
Yung-Jen
YJ
Chung
Hui-Hsuan
HH
Wu
Jiunn-Ren
JR
Chen
Ing-Jun
IJ
Wu
Bin-Nan
BN
D000818:Animals; D015153:Blotting, Western; D002118:Calcium / Q000378:metabolism*; D002908:Chronic Disease; D005260:Female; D006976:Hypertension, Pulmonary / Q000517:prevention & control*; D016686:Monocrotaline; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009213:Myography; D010880:Piperidines / Q000494:pharmacology*; D024681:Potassium Channels, Calcium-Activated / Q000187:drug effects / Q000235:genetics; D024642:Potassium Channels, Voltage-Gated / Q000187:drug effects / Q000378:metabolism; D011651:Pulmonary Artery / Q000187:drug effects* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D015854:Up-Regulation / Q000187:drug effects; D014970:Xanthines / Q000494:pharmacology*; D054460:rho-Associated Kinases / Q000378:metabolism; D020742:rhoA GTP-Binding Protein / Q000378:metabolism
D010880:Piperidines; D024681:Potassium Channels, Calcium-Activated; D024642:Potassium Channels, Voltage-Gated; D014970:Xanthines; C439304:KMUP 1; D016686:Monocrotaline; D054460:rho-Associated Kinases; D020742:rhoA GTP-Binding Protein; D002118:Calcium