title: 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] controls growth plate development by inhibiting apoptosis in the reserve zone and stimulating response to 1alpha,25(OH)2D3 in hypertrophic cells.
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, ATlanta, GA 30332-0363, USA. barbara.boyan@bme.gatech.edu
authors.forename: B D
authors.initials: BD
authors.lastname: Boyan
authors.forename: J
authors.initials: J
authors.lastname: Hurst-Kennedy
authors.forename: T A
authors.initials: TA
authors.lastname: Denison
authors.forename: Z
authors.initials: Z
authors.lastname: Schwartz
mesh_terms: D015650:24,25-Dihydroxyvitamin D 3 / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D002117:Calcitriol / Q000378:metabolism*; D053148:Caspase 3 / Q000378:metabolism; D049109:Cell Proliferation; D019902:Chondrocytes / Q000166:cytology; D004789:Enzyme Activation; D006132:Growth Plate / Q000187:drug effects / Q000378:metabolism*; D006984:Hypertrophy; D008246:Lysophospholipids / Q000378:metabolism; D008297:Male; D054467:Phospholipases A2 / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D008246:Lysophospholipids; D016159:Tumor Suppressor Protein p53; D015650:24,25-Dihydroxyvitamin D 3; D054467:Phospholipases A2; D053148:Caspase 3; D002117:Calcitriol; C032881:lysophosphatidic acid