Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function.
Eggink
Dirk
D
Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
Melchers
Mark
M
Wuhrer
Manfred
M
van Montfort
Thijs
T
Dey
Antu K
AK
Naaijkens
Benno A
BA
David
Kathryn B
KB
Le Douce
Valentin
V
Deelder
André M
AM
Kang
Kenneth
K
Olson
William C
WC
Berkhout
Ben
B
Hokke
Cornelis H
CH
Moore
John P
JP
Sanders
Rogier W
RW
D002240:Carbohydrate Sequence; D002460:Cell Line; D015497:HIV-1 / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017351:N-Acetylglucosaminyltransferases / Q000172:deficiency; D011134:Polysaccharides / Q000032:analysis*; D011487:Protein Conformation; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics; D053586:Virus Internalization; D014779:Virus Replication; D054299:env Gene Products, Human Immunodeficiency Virus / Q000737:chemistry* / Q000235:genetics
D011134:Polysaccharides; D011994:Recombinant Proteins; D054299:env Gene Products, Human Immunodeficiency Virus; D017351:N-Acetylglucosaminyltransferases; C024850:alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase I