Fine-tuning synthesis of Yersinia pestis LcrV from runaway-like replication balanced-lethal plasmid in a Salmonella enterica serovar typhimurium vaccine induces protection against a lethal Y. pestis challenge in mice.
Torres-Escobar
Ascención
A
Center for Infectious Diseases and Vaccinology at Biodesign Institute and School of Life Sciences, Arizona State University, Tempe, Arizona 85287-5401, USA.
Juárez-Rodríguez
María Dolores
MD
Gunn
Bronwyn M
BM
Branger
Christine G
CG
Tinge
Steven A
SA
Curtiss
Roy
R
D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics / Q000276:immunology*; D001428:Bacterial Vaccines / Q000235:genetics / Q000276:immunology*; D005260:Female; D005822:Genetic Vectors; D051379:Mice; D008807:Mice, Inbred BALB C; D010930:Plague / Q000517:prevention & control*; D010957:Plasmids; D052899:Pore Forming Cytotoxic Proteins / Q000235:genetics / Q000276:immunology*; D012486:Salmonella typhimurium / Q000235:genetics / Q000276:immunology*; D016019:Survival Analysis; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D015010:Yersinia pestis / Q000235:genetics / Q000276:immunology*
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; C043908:LcrV protein, Yersinia; D052899:Pore Forming Cytotoxic Proteins