Estrogen receptor alpha 46 is reduced in tamoxifen resistant breast cancer cells and re-expression inhibits cell proliferation and estrogen receptor alpha 66-regulated target gene transcription.
Klinge
Carolyn M
CM
Department of Biochemistry & Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA. Carolyn.klinge@louisville.edu
Riggs
Krista A
KA
Wickramasinghe
Nalinie S
NS
Emberts
Celia G
CG
McConda
David B
DB
Barry
Parul N
PN
Magnusen
Joan E
JE
D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D019938:Cyclin D1 / Q000378:metabolism; D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D047628:Estrogen Receptor alpha / Q000235:genetics / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D013629:Tamoxifen / Q000627:therapeutic use*; D014158:Transcription, Genetic; D014183:Transplantation, Heterologous
D047628:Estrogen Receptor alpha; D035683:MicroRNAs; D020033:Protein Isoforms; D013629:Tamoxifen; D019938:Cyclin D1; D051059:PTEN Phosphohydrolase