Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract.
Bryant
Alexander P
AP
Ironwood Pharmaceuticals, Inc., 320 Bent Street, Cambridge, MA 02141, USA. abryant@ironwoodpharma.com
Busby
Robert W
RW
Bartolini
Wilmin P
WP
Cordero
Etchell A
EA
Hannig
Gerhard
G
Kessler
Marco M
MM
Pierce
Christine M
CM
Solinga
Robert M
RM
Tobin
Jenny V
JV
Mahajan-Miklos
Shalina
S
Cohen
Mitchell B
MB
Kurtz
Caroline B
CB
Currie
Mark G
MG
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D005260:Female; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000378:metabolism; D005772:Gastrointestinal Transit / Q000187:drug effects; D006162:Guanylate Cyclase / Q000235:genetics; D007413:Intestinal Mucosa / Q000378:metabolism; D007419:Intestinal Secretions / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010455:Peptides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled; D018000:Receptors, Peptide / Q000819:agonists* / Q000235:genetics
D005765:Gastrointestinal Agents; D010455:Peptides; D018000:Receptors, Peptide; D006162:Guanylate Cyclase; C000613655:Gucy2c protein, mouse; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled; C523483:linaclotide