Farnesyl diphosphate synthase attenuates paclitaxel-induced apoptotic cell death in human glioblastoma U87MG cells.
Woo
Im Sun
IS
Department of Pharmacology, Gyeongsang Institute of Health Science, Gyeongsang National University School of Medicine, 92 Chilam-dong, Jinju 660-751, Republic of Korea.
Eun
So Young
SY
Kim
Hyo Jung
HJ
Kang
Eun Sil
ES
Kim
Hye Jung
HJ
Lee
Jae Heun
JH
Chang
Ki Churl
KC
Kim
Jin-Hoi
JH
Hong
Soon-Chan
SC
Seo
Han Geuk
HG
D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004164:Diphosphonates / Q000494:pharmacology; D004357:Drug Synergism; D005434:Flow Cytometry / Q000379:methods; D051228:Geranyltranstransferase / Q000235:genetics / Q000378:metabolism*; D005909:Glioblastoma / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D008798:Mevalonic Acid / Q000494:pharmacology; D017239:Paclitaxel / Q000494:pharmacology*; D000077268:Pamidronate; D011106:Polyisoprenyl Phosphates / Q000378:metabolism; D012717:Sesquiterpenes / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D000972:Antineoplastic Agents, Phytogenic; D004164:Diphosphonates; D011106:Polyisoprenyl Phosphates; D012717:Sesquiterpenes; D016159:Tumor Suppressor Protein p53; C004808:farnesyl pyrophosphate; D051228:Geranyltranstransferase; D048031:JNK Mitogen-Activated Protein Kinases; D000077268:Pamidronate; D017239:Paclitaxel; D008798:Mevalonic Acid