title: Single-dose, multiple-dose, and population pharmacokinetics of pantoprazole in neonates and preterm infants with a clinical diagnosis of gastroesophageal reflux disease (GERD).
authors.affiliation: Pediatric Pharmacology Program, Department of Pediatrics, University of Utah, 417 Wakara, Suite 3510, Salt Lake, UT, 84108, USA. Robert.Ward@hsc.utah.edu
authors.forename: Robert M
authors.initials: RM
authors.lastname: Ward
authors.forename: Brinda
authors.initials: B
authors.lastname: Tammara
authors.forename: Sandra E
authors.initials: SE
authors.lastname: Sullivan
authors.forename: Dan L
authors.initials: DL
authors.lastname: Stewart
authors.forename: Natalie
authors.initials: N
authors.lastname: Rath
authors.forename: Xu
authors.initials: X
authors.lastname: Meng
authors.forename: Mary K
authors.initials: MK
authors.lastname: Maguire
authors.forename: Gail M
authors.initials: GM
authors.lastname: Comer
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000367:Age Factors; D000897:Anti-Ulcer Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics; D065731:Cytochrome P-450 CYP2C19; D051544:Cytochrome P-450 CYP3A / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005764:Gastroesophageal Reflux / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy* / Q000208:ethnology; D005838:Genotype; D006207:Half-Life; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D000077402:Pantoprazole; D054328:Proton Pump Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D000077402:Pantoprazole; D001189:Aryl Hydrocarbon Hydroxylases; C045793:CYP2C19 protein, human; D065731:Cytochrome P-450 CYP2C19; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human