Mycophenolic acid inhibits the phosphorylation of NF-kappaB and JNKs and causes a decrease in IL-8 release in H2O2-treated human renal proximal tubular cells.
Andreucci
Michele
M
Chair of Nephrology, Magna Graecia University, Catanzaro, Italy. andreucci@unicz.it
Faga
Teresa
T
Lucisano
Gaetano
G
Uccello
Francesco
F
Pisani
Antonio
A
Memoli
Bruno
B
Sabbatini
Massimo
M
Fuiano
Giorgio
G
Michael
Ashour
A
D002460:Cell Line; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D016209:Interleukin-8 / Q000378:metabolism*; D048031:JNK Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors*; D007687:Kidney Tubules, Proximal / Q000166:cytology / Q000378:metabolism*; D009173:Mycophenolic Acid / Q000378:metabolism*; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D010766:Phosphorylation
D016209:Interleukin-8; D016328:NF-kappa B; D006861:Hydrogen Peroxide; D048031:JNK Mitogen-Activated Protein Kinases; D009173:Mycophenolic Acid