An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors.
Stürzebecher
Annika S
AS
Molecular Neurobiology group, Department of Neuroscience, Max-Delbrück Center for Molecular Medicine, Robert-Rössle Strasse 10, 13125 Berlin, Germany.
Hu
Jing
J
Smith
Ewan St John
ES
Frahm
Silke
S
Santos-Torres
Julio
J
Kampfrath
Branka
B
Auer
Sebastian
S
Lewin
Gary R
GR
Ibañez-Tallon
Inés
I
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D015139:Blotting, Southern; D022202:Chromosomes, Artificial, Bacterial / Q000235:genetics; D020916:Conotoxins / Q000737:chemistry / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis / Q000235:genetics; D004594:Electrophysiology; D005260:Female; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D015640:Ion Channel Gating / Q000187:drug effects / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D009475:Neurons, Afferent / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects* / Q000502:physiology; D009865:Oocytes / Q000502:physiology; D010146:Pain / Q000523:psychology; D018408:Patch-Clamp Techniques; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012867:Skin / Q000294:innervation; D026941:Sodium Channel Blockers / Q000737:chemistry / Q000494:pharmacology*; D015222:Sodium Channels / Q000187:drug effects* / Q000235:genetics; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism; D014982:Xenopus laevis
D020916:Conotoxins; D026941:Sodium Channel Blockers; D015222:Sodium Channels; C093338:conotoxin MrVIA; D004247:DNA