Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
Hong
Bum Soo
BS
Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
Allali-Hassani
Abdellah
A
Tempel
Wolfram
W
Finerty
Patrick J
PJ
Mackenzie
Farrell
F
Dimov
Svetoslav
S
Vedadi
Masoud
M
Park
Hee-Won
HW
D020134:Catalytic Domain; D002797:Choline Kinase / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D018678:Cholinergic Agents / Q000737:chemistry / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000378:metabolism; D006426:Hemicholinium 3 / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007527:Isoenzymes; D013058:Mass Spectrometry; D020125:Mutation, Missense; D010766:Phosphorylation
D018678:Cholinergic Agents; D004791:Enzyme Inhibitors; D007527:Isoenzymes; D006426:Hemicholinium 3; C517212:CHKA protein, human; C542592:CHKB protein, human; D002797:Choline Kinase