Ligation of beta4 integrins activates PKB/Akt and ERK1/2 by distinct pathways-relevance of the keratin filament.
Kippenberger
Stefan
S
Department of Dermatology and Venerology, University of Frankfurt Medical School, D-60590 Frankfurt/Main, Germany. kippenberger@em.uni-frankfurt.de
Hofmann
Matthias
M
Zöller
Nadja
N
Thaçi
Diamant
D
Müller
Jutta
J
Kaufmann
Roland
R
Bernd
August
A
D000730:Androstadienes / Q000378:metabolism; D000818:Animals; D002460:Cell Line; D002867:Chromones / Q000378:metabolism; D004789:Enzyme Activation; D004847:Epithelial Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D039663:Integrin beta4 / Q000235:genetics / Q000378:metabolism*; D007633:Keratins / Q000378:metabolism*; D051379:Mice; D019950:Mitogen-Activated Protein Kinase 1 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D048052:Mitogen-Activated Protein Kinase 3 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D009025:Morpholines / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D000077191:Wortmannin
D000730:Androstadienes; D002867:Chromones; D039663:Integrin beta4; D009025:Morpholines; D047428:Protein Kinase Inhibitors; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; D007633:Keratins; D051057:Proto-Oncogene Proteins c-akt; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D000077191:Wortmannin