title: Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors.
authors.affiliation: Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath,Claverton Down, Bath BA2 7AY, United Kingdom.
authors.forename: Gyles E
authors.initials: GE
authors.lastname: Cozier
authors.forename: Mathew P
authors.initials: MP
authors.lastname: Leese
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Lloyd
authors.forename: Matthew D
authors.initials: MD
authors.lastname: Baker
authors.forename: Nethaji
authors.initials: N
authors.lastname: Thiyagarajan
authors.forename: K Ravi
authors.initials: KR
authors.lastname: Acharya
authors.forename: Barry V L
authors.initials: BV
authors.lastname: Potter
mesh_terms: D001639:Bicarbonates / Q000378:metabolism; D001665:Binding Sites; D002245:Carbon Dioxide / Q000378:metabolism; D024402:Carbonic Anhydrase II / Q000037:antagonists & inhibitors / Q000737:chemistry*; D003124:Colorimetry; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D004970:Estrone / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D011487:Protein Conformation
chemical_list: D001639:Bicarbonates; D004791:Enzyme Inhibitors; D002245:Carbon Dioxide; C088768:estrone-3-O-sulfamate; D004970:Estrone; D024402:Carbonic Anhydrase II