Polychlorinated biphenyls PCB 52, PCB 180, and PCB 138 impair the glutamate-nitric oxide-cGMP pathway in cerebellar neurons in culture by different mechanisms.
Llansola
Marta
M
Laboratory of Neurobiology, Centro de Investigacion Principe Felipe, Avda Autopista del Saler, 16, 46012 Valencia, Spain.
Montoliu
Carmina
C
Boix
Jordi
J
Felipo
Vicente
V
D000818:Animals; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology*; D006152:Cyclic GMP / Q000378:metabolism*; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000737:chemistry / Q000633:toxicity*; D018698:Glutamic Acid / Q000378:metabolism*; D006162:Guanylate Cyclase / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000737:chemistry / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D000071756:Soluble Guanylyl Cyclase
D004785:Environmental Pollutants; D018160:Receptors, Cytoplasmic and Nuclear; D016194:Receptors, N-Methyl-D-Aspartate; C009407:2,5,2',5'-tetrachlorobiphenyl; D009569:Nitric Oxide; D018698:Glutamic Acid; C410127:PCB 180; C029790:2,2',3',4,4',5-hexachlorobiphenyl; D011078:Polychlorinated Biphenyls; D019001:Nitric Oxide Synthase; D006162:Guanylate Cyclase; D000071756:Soluble Guanylyl Cyclase; D006152:Cyclic GMP