Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity.
Scudiero
Olga
O
CEINGE-Biotecnologie Avanzate, Naples, Italy. salvator@unina.it
Galdiero
Stefania
S
Cantisani
Marco
M
Di Noto
Rosa
R
Vitiello
Mariateresa
M
Galdiero
Massimiliano
M
Naclerio
Gino
G
Cassiman
Jean-Jacques
JJ
Pedone
Carlo
C
Castaldo
Giuseppe
G
Salvatore
Francesco
F
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D015195:Drug Design; D004755:Enterobacteriaceae / Q000187:drug effects; D018259:Herpesvirus 1, Human / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015202:Protein Engineering; D017434:Protein Structure, Tertiary; D011994:Recombinant Proteins / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology; D017386:Sequence Homology, Amino Acid; D023083:beta-Defensins / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000998:Antiviral Agents; C406407:DEFB1 protein, human; C422950:DEFB103A protein, human; D011994:Recombinant Proteins; D023083:beta-Defensins