The L-, N-, and T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family.
Kosaka
Hiromichi
H
Drug Discovery Research Laboratories, Kyowa Hakko Kirin Co., Ltd., Sunto-gun, Shizuoka, Japan.
Hirayama
Kazunori
K
Yoda
Nobuyuki
N
Sasaki
Katsutoshi
K
Kitayama
Tetsuya
T
Kusaka
Hideaki
H
Matsubara
Masahiro
M
D000450:Aldosterone / Q000494:pharmacology; D001665:Binding Sites; D002121:Calcium Channel Blockers / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D020746:Calcium Channels, L-Type / Q000378:metabolism; D020864:Calcium Channels, N-Type / Q000378:metabolism; D020747:Calcium Channels, T-Type / Q000378:metabolism; D002460:Cell Line; D004095:Dihydropyridines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000077545:Eplerenone; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists; D008958:Models, Molecular; D008968:Molecular Conformation; D009154:Mutation; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology; D018161:Receptors, Mineralocorticoid / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013148:Spironolactone / Q000031:analogs & derivatives / Q000494:pharmacology; D013237:Stereoisomerism
D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D020864:Calcium Channels, N-Type; D020747:Calcium Channels, T-Type; D004095:Dihydropyridines; D000451:Mineralocorticoid Receptor Antagonists; D011725:Pyridines; D018161:Receptors, Mineralocorticoid; D013148:Spironolactone; D000450:Aldosterone; C061004:benidipine; D000077545:Eplerenone