Relations between toxicity and altered tissue distribution and urinary excretion of nicotine, cotinine, and hydroxycotinine after chronic oral administration of nicotine in rats.
Kim
Ki Young
KY
Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, Seoul, Korea.
Lee
Young-Joo
YJ
Chung
Bong Chul
BC
Hong
Jongki
J
Jung
Byung Hwa
BH
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001774:Blood Chemical Analysis; D001806:Blood Urea Nitrogen; D001921:Brain / Q000187:drug effects / Q000473:pathology; D003367:Cotinine / Q000031:analogs & derivatives / Q000652:urine*; D005731:Ganglionic Stimulants / Q000493:pharmacokinetics* / Q000633:toxicity* / Q000652:urine; D008401:Gas Chromatography-Mass Spectrometry; D005982:Glutathione Transferase / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D009538:Nicotine / Q000493:pharmacokinetics* / Q000633:toxicity* / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D005731:Ganglionic Stimulants; C001381:hydroxycotinine; D009538:Nicotine; D005982:Glutathione Transferase; D001219:Aspartate Aminotransferases; D003367:Cotinine