A novel cyclopeptide from the cyclization of PACAP(1-5) with potent activity towards PAC1 attenuates STZ-induced diabetes.
Yu
Rongjie
R
Engineering Institute of Jinan University, Jinan University, Guangzhou 510630, PR China. rongjie yu1123@13.com
Wang
Jingjing
J
Li
Juan
J
Wang
Ye
Y
Zhang
Huahua
H
Chen
Jiansu
J
Huang
Lin
L
Liu
Xiaofei
X
D000818:Animals; D016466:CHO Cells; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D000242:Cyclic AMP / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D010456:Peptides, Cyclic / Q000627:therapeutic use*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000378:metabolism*; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I / Q000187:drug effects*; D013311:Streptozocin
D010456:Peptides, Cyclic; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; C551461:cysteinyl-histidyl-seryl-aspartyl-glycyl-isoleucyl-cysteine cyclic (1-7) disulfide; D013311:Streptozocin; D000242:Cyclic AMP