title: Homozygous triplicate mutations in three 16S rRNA genes responsible for high-level aminoglycoside resistance in Nocardia farcinica clinical isolates from a Canada-wide bovine mastitis epizootic.
authors.affiliation: Medical Mycology Research Center, Chiba University, Chuo-ku, Chiba-shi 260-8673, Japan.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Kogure
authors.forename: Reona
authors.initials: R
authors.lastname: Shimada
authors.forename: Jun
authors.initials: J
authors.lastname: Ishikawa
authors.forename: Katsukiyo
authors.initials: K
authors.lastname: Yazawa
authors.forename: June M
authors.initials: JM
authors.lastname: Brown
authors.forename: Yuzuru
authors.initials: Y
authors.lastname: Mikami
authors.forename: Tohru
authors.initials: T
authors.lastname: Gonoi
mesh_terms: D000583:Amikacin / Q000494:pharmacology; D000617:Aminoglycosides / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001483:Base Sequence; D002170:Canada / Q000453:epidemiology; D002417:Cattle; D017931:DNA Primers / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics; D005260:Female; D005798:Genes, Bacterial; D006720:Homozygote; D066298:In Vitro Techniques; D008414:Mastitis, Bovine / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D009615:Nocardia / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D009617:Nocardia Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D017354:Point Mutation; D012329:RNA, Bacterial / Q000235:genetics*; D012336:RNA, Ribosomal, 16S / Q000235:genetics*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D017931:DNA Primers; D012329:RNA, Bacterial; D012336:RNA, Ribosomal, 16S; D000583:Amikacin