title: Cyclic sulfones as novel P3-caps for hepatitis C virus NS3/4A (HCV NS3/4A) protease inhibitors: synthesis and evaluation of inhibitors with improved potency and pharmacokinetic profiles.
authors.affiliation: Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033-1300, USA. francisco.velazquez@spcorp.com
authors.forename: Francisco
authors.initials: F
authors.lastname: Velázquez
authors.forename: Mousumi
authors.initials: M
authors.lastname: Sannigrahi
authors.forename: Frank
authors.initials: F
authors.lastname: Bennett
authors.forename: Raymond G
authors.initials: RG
authors.lastname: Lovey
authors.forename: Ashok
authors.initials: A
authors.lastname: Arasappan
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bogen
authors.forename: Latha
authors.initials: L
authors.lastname: Nair
authors.forename: Srikanth
authors.initials: S
authors.lastname: Venkatraman
authors.forename: Melissa
authors.initials: M
authors.lastname: Blackman
authors.forename: Siska
authors.initials: S
authors.lastname: Hendrata
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Huang
authors.forename: Regina
authors.initials: R
authors.lastname: Huelgas
authors.forename: Patrick
authors.initials: P
authors.lastname: Pinto
authors.forename: Kuo-Chi
authors.initials: KC
authors.lastname: Cheng
authors.forename: Xiao
authors.initials: X
authors.lastname: Tong
authors.forename: Andrew T
authors.initials: AT
authors.lastname: McPhail
authors.forename: F George
authors.initials: FG
authors.lastname: Njoroge
mesh_terms: D000284:Administration, Oral; D000818:Animals; D018360:Crystallography, X-Ray; D000882:Haplorhini; D016174:Hepacivirus / Q000201:enzymology*; D008958:Models, Molecular; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013450:Sulfones / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: C549336:N-(1-(2-(cyclopropylamino)-1,2-dioxoethyl)butyl)-6,6-dimethyl-3-(2-(1-methylcyclohexyl)-2-((((1-(tetrahydro-1,1-dioxido-2-thienyl)cyclohexyl)amino)carbonyl)amino)acetyl)-3-azabicyclo(3.1.0)hexane-2-carboxamide; C549335:N-(1-(2-(cyclopropylamino)-1,2-dioxoethyl)pentyl)-6,6-dimethyl-3-(2-(1-methylcyclohexyl)-2-((((1-(tetrahydro-1,1-dioxido-2-thienyl)cyclohexyl)amino)carbonyl)amino)acetyl)-3-azabicyclo(3.1.0)hexane-2-carboxamide; D009842:Oligopeptides; D015842:Serine Proteinase Inhibitors; D013450:Sulfones