HMBA depolymerizes microtubules, activates mitotic checkpoints and induces mitotic block in MCF-7 cells by binding at the colchicine site in tubulin.
Chatterji
Biswa Prasun
BP
Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.
Banerjee
Mithu
M
Singh
Parminder
P
Panda
Dulal
D
D000081:Acetamides / Q000737:chemistry / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001665:Binding Sites; D001943:Breast Neoplasms / Q000473:pathology; D045744:Cell Line, Tumor; D003078:Colchicine / Q000378:metabolism; D005260:Female; D006801:Humans; D008870:Microtubules / Q000378:metabolism*; D008938:Mitosis / Q000187:drug effects*; D015394:Molecular Structure; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism*
D000081:Acetamides; D000970:Antineoplastic Agents; D014404:Tubulin; C014026:hexamethylene bisacetamide; D003078:Colchicine