Synthesis and preliminary pharmacological characterisation of a new class of nitrogen-containing bisphosphonates (N-BPs).
Lolli
Marco L
ML
Dipartimento di Scienza e Tecnologia del Farmaco, Università degli Studi di Torino, Via Pietro Giuria 9, 10125 Torino, Italy.
Rolando
Barbara
B
Tosco
Paolo
P
Chaurasia
Shilpi
S
Di Stilo
Antonella
A
Lazzarato
Loretta
L
Gorassini
Eva
E
Ferracini
Riccardo
R
Oliaro-Bosso
Simonetta
S
Fruttero
Roberta
R
Gasco
Alberto
A
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured; D002846:Chromatography, Affinity; D004164:Diphosphonates / Q000138:chemical synthesis* / Q000494:pharmacology*; D017886:Durapatite / Q000737:chemistry; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors; D006801:Humans; D000077557:Ibandronic Acid; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D008958:Models, Molecular; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D020030:Nitric Oxide Donors / Q000138:chemical synthesis / Q000494:pharmacology; D009584:Nitrogen / Q000737:chemistry*; D010012:Osteogenesis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000138:chemical synthesis / Q000494:pharmacology
D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D020030:Nitric Oxide Donors; D014665:Vasodilator Agents; D017886:Durapatite; D013186:Farnesyl-Diphosphate Farnesyltransferase; D009584:Nitrogen; D000077557:Ibandronic Acid