Lipophilic cationic drugs increase the permeability of lysosomal membranes in a cell culture system.
Kornhuber
Johannes
J
Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany. johannes.kornhuber@uk-erlangen.de
Henkel
Andreas W
AW
Groemer
Teja W
TW
Städtler
Sven
S
Welzel
Oliver
O
Tripal
Philipp
P
Rotter
Andrea
A
Bleich
Stefan
S
Trapp
Stefan
S
D000547:Amantadine / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000588:Amines; D000639:Amitriptyline / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D002412:Cations; D045744:Cell Line, Tumor; D002936:Cinnarizine / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D003198:Computer Simulation; D025461:Feedback, Physiological; D005422:Flavoxate / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D005456:Fluorescent Dyes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008247:Lysosomes / Q000187:drug effects* / Q000378:metabolism; D008856:Microscopy, Fluorescence; D008954:Models, Biological; D053141:Organelle Size; D010539:Permeability
D000588:Amines; D002412:Cations; D005456:Fluorescent Dyes; C493330:Red DND-99; D000639:Amitriptyline; D002936:Cinnarizine; D005422:Flavoxate; D000547:Amantadine