Direct, one-pot sequential reductive alkylation of lactams/amides with Grignard and organolithium reagents through lactam/amide activation.
Xiao
Kai-Jiong
KJ
Department of Chemistry and The Key Laboratory for Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian 361005, China.
Luo
Jie-Min
JM
Ye
Ke-Yin
KY
Wang
Yu
Y
Huang
Pei-Qiang
PQ
D000478:Alkylation; D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D007769:Lactams / Q000737:chemistry*; D018020:Lithium Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction
D000577:Amides; D000588:Amines; D007769:Lactams; D018020:Lithium Compounds