title: Estrogen receptor alpha 46 is reduced in tamoxifen resistant breast cancer cells and re-expression inhibits cell proliferation and estrogen receptor alpha 66-regulated target gene transcription.
authors.affiliation: Department of Biochemistry & Molecular Biology, Center for Genetics and Molecular Medicine, University of Louisville School of Medicine, Louisville, KY 40292, USA. Carolyn.klinge@louisville.edu
authors.forename: Carolyn M
authors.initials: CM
authors.lastname: Klinge
authors.forename: Krista A
authors.initials: KA
authors.lastname: Riggs
authors.forename: Nalinie S
authors.initials: NS
authors.lastname: Wickramasinghe
authors.forename: Celia G
authors.initials: CG
authors.lastname: Emberts
authors.forename: David B
authors.initials: DB
authors.lastname: McConda
authors.forename: Parul N
authors.initials: PN
authors.lastname: Barry
authors.forename: Joan E
authors.initials: JE
authors.lastname: Magnusen
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D019938:Cyclin D1 / Q000378:metabolism; D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D047628:Estrogen Receptor alpha / Q000235:genetics / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D051059:PTEN Phosphohydrolase / Q000235:genetics / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D013629:Tamoxifen / Q000627:therapeutic use*; D014158:Transcription, Genetic; D014183:Transplantation, Heterologous
chemical_list: D047628:Estrogen Receptor alpha; D035683:MicroRNAs; D020033:Protein Isoforms; D013629:Tamoxifen; D019938:Cyclin D1; D051059:PTEN Phosphohydrolase