title: Intratumoral injection of interferon-α and systemic delivery of agonist anti-CD137 monoclonal antibodies synergize for immunotherapy.
authors.affiliation: CIMA and Clinica Universitaria, Universidad de Navarra, Pamplona, Spain.
authors.forename: Juan
authors.initials: J
authors.lastname: Dubrot
authors.forename: Asis
authors.initials: A
authors.lastname: Palazón
authors.forename: Carlos
authors.initials: C
authors.lastname: Alfaro
authors.forename: Arantza
authors.initials: A
authors.lastname: Azpilikueta
authors.forename: María Carmen
authors.initials: MC
authors.lastname: Ochoa
authors.forename: Ana
authors.initials: A
authors.lastname: Rouzaut
authors.forename: Iván
authors.initials: I
authors.lastname: Martinez-Forero
authors.forename: Alvaro
authors.initials: A
authors.lastname: Teijeira
authors.forename: Pedro
authors.initials: P
authors.lastname: Berraondo
authors.forename: Agnes
authors.initials: A
authors.lastname: Le Bon
authors.forename: Sandra
authors.initials: S
authors.lastname: Hervás-Stubbs
authors.forename: Ignacio
authors.initials: I
authors.lastname: Melero
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001854:Bone Marrow Cells / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004357:Drug Synergism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D015552:Injections, Intralesional; D007274:Injections, Intraperitoneal; D016898:Interferon-alpha / Q000008:administration & dosage; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009374:Neoplasms, Experimental / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D053633:Receptor, Interferon alpha-beta / Q000172:deficiency* / Q000235:genetics; D016019:Survival Analysis; D047368:Tumor Burden / Q000187:drug effects; D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9 / Q000819:agonists / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D016898:Interferon-alpha; D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9; D053633:Receptor, Interferon alpha-beta