Genistein directly inhibits native and recombinant NMDA receptors.
Huang
Renqi
R
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, USA. rhuang@hsc.unt.edu
Singh
Meharvan
M
Dillon
Glenn H
GH
D000818:Animals; D000831:Animals, Newborn; D019833:Genistein / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D015640:Ion Channel Gating; D007529:Isoflavones / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D018408:Patch-Clamp Techniques; D010636:Phenols / Q000494:pharmacology; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000235:genetics; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000235:genetics
D007529:Isoflavones; C473649:NR1A NMDA receptor, rat; C120997:NR2A NMDA receptor; C121001:NR2B NMDA receptor; D010636:Phenols; D016194:Receptors, N-Methyl-D-Aspartate; D011994:Recombinant Proteins; C062898:lavendustin A; C004742:daidzein; D019833:Genistein; D011505:Protein-Tyrosine Kinases