Coordinated regulation of dorsal bone morphogenetic protein 4 and ventral Sonic hedgehog signaling specifies the dorso-ventral polarity in the optic vesicle and governs ocular morphogenesis through fibroblast growth factor 8 upregulation.
Kobayashi
Takuma
T
Developmental Neurobiology Laboratory, Department of Biological Sciences, Nara Women's University, Nara, Japan.
Yasuda
Kunio
K
Araki
Masasuke
M
D000818:Animals; D019521:Body Patterning / Q000235:genetics; D055415:Bone Morphogenetic Protein 4 / Q000235:genetics* / Q000494:pharmacology; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D002642:Chick Embryo; D005123:Eye / Q000196:embryology / Q000378:metabolism; D051524:Fibroblast Growth Factor 8 / Q000235:genetics* / Q000494:pharmacology; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D053823:Hedgehog Proteins / Q000235:genetics* / Q000494:pharmacology; D017403:In Situ Hybridization; D051739:Microphthalmia-Associated Transcription Factor / Q000235:genetics; D009924:Organ Culture Techniques; D051857:Otx Transcription Factors / Q000235:genetics; D051762:PAX2 Transcription Factor / Q000235:genetics; D055213:Retinal Pigment Epithelium / Q000187:drug effects / Q000196:embryology / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics; D020825:T-Box Domain Proteins / Q000235:genetics
D055415:Bone Morphogenetic Protein 4; D053823:Hedgehog Proteins; D051739:Microphthalmia-Associated Transcription Factor; D051857:Otx Transcription Factors; D051762:PAX2 Transcription Factor; D020825:T-Box Domain Proteins; C103172:T-box transcription factor 5; D051524:Fibroblast Growth Factor 8