Aldose reductase regulates vascular smooth muscle cell proliferation by modulating G1/S phase transition of cell cycle.
Tammali
Ravinder
R
Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555-0647, USA.
Saxena
Ashish
A
Srivastava
Satish K
SK
Ramana
Kota V
KV
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001011:Aorta / Q000378:metabolism; D015153:Blotting, Western; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology*; D049109:Cell Proliferation; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D016213:Cyclins / Q000235:genetics / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000235:genetics / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D050687:E2F1 Transcription Factor / Q000235:genetics / Q000378:metabolism; D016193:G1 Phase; D005947:Glucose / Q000494:pharmacology; D048289:Imidazolidines / Q000494:pharmacology; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D010766:Phosphorylation / Q000187:drug effects; D034622:RNA Interference; D051381:Rats; D017207:Rats, Sprague-Dawley; D016160:Retinoblastoma Protein / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016196:S Phase; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D016213:Cyclins; D050687:E2F1 Transcription Factor; C493755:E2f1 protein, rat; D048289:Imidazolidines; D016160:Retinoblastoma Protein; D014409:Tumor Necrosis Factor-alpha; D000449:Aldehyde Reductase; C026411:sorbinil; D005947:Glucose