Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells.
Kim
Ella L
EL
The Translational Neurooncology Research Group, Department of Neurosurgery, Georg-August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany. ella.kim@med.uni-goettingen.de
Wüstenberg
Robin
R
Rübsam
Anne
A
Schmitz-Salue
Christoph
C
Warnecke
Gabriele
G
Bücker
Eva-Maria
EM
Pettkus
Nadine
N
Speidel
Daniel
D
Rohde
Veit
V
Schulz-Schaeffer
Walter
W
Deppert
Wolfgang
W
Giese
Alf
A
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D015153:Blotting, Western; D001932:Brain Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D049109:Cell Proliferation; D002738:Chloroquine / Q000494:pharmacology*; D005910:Glioma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D010766:Phosphorylation / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D034741:RNA, Small Interfering / Q000494:pharmacology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014158:Transcription, Genetic / Q000187:drug effects; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D000962:Antimalarials; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D016159:Tumor Suppressor Protein p53; D002738:Chloroquine