Xanthohumol and related prenylated flavonoids inhibit inflammatory cytokine production in LPS-activated THP-1 monocytes: structure-activity relationships and in silico binding to myeloid differentiation protein-2 (MD-2).
Peluso
Michael R
MR
Linus Pauling Institute, Oregon State University, Corvallis, Oregon, USA.
Miranda
Cristobal L
CL
Hobbs
Deborah J
DJ
Proteau
Rosita R
RR
Stevens
Jan Frederik
JF
D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D018932:Chemokine CCL2 / Q000096:biosynthesis; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D027582:Humulus / Q000737:chemistry; D015850:Interleukin-6 / Q000096:biosynthesis; D008070:Lipopolysaccharides / Q000494:pharmacology; D051218:Lymphocyte Antigen 96 / Q000737:chemistry* / Q000378:metabolism; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D054876:Prenylation; D011427:Propiophenones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D005419:Flavonoids; D015850:Interleukin-6; D008070:Lipopolysaccharides; D051218:Lymphocyte Antigen 96; D011427:Propiophenones; C104536:xanthohumol