Ganglioside synthase knockout in oncogene-transformed fibroblasts depletes gangliosides and impairs tumor growth.
Liu
Y
Y
Center for Cancer and Immunology Research, Children's National Medical Center, NW, Washington, DC 20010, USA.
Yan
S
S
Wondimu
A
A
Bob
D
D
Weiss
M
M
Sliwinski
K
K
Villar
J
J
Notario
V
V
Sutherland
M
M
Colberg-Poley
A M
AM
Ladisch
S
S
D000818:Animals; D048708:Cell Growth Processes / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism; D002478:Cells, Cultured; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D005732:Gangliosides / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D016259:Genes, myc; D011905:Genes, ras; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017350:N-Acetylgalactosaminyltransferases / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D009857:Oncogenes; D012799:Sialyltransferases / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism
D005732:Gangliosides; D017350:N-Acetylgalactosaminyltransferases; C023220:(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase; D012799:Sialyltransferases; C021343:haematoside synthetase