title: Bortezomib decreases Rb phosphorylation and induces caspase-dependent apoptosis in Imatinib-sensitive and -resistant Bcr-Abl1-expressing cells.
authors.affiliation: Department of Chemistry, Biochemistry and Molecular Biology, Cardenal Herrera-CEU University, Moncada, Spain.
authors.forename: M P
authors.initials: MP
authors.lastname: Albero
authors.forename: J M
authors.initials: JM
authors.lastname: Vaquer
authors.forename: E J
authors.initials: EJ
authors.lastname: Andreu
authors.forename: J J
authors.initials: JJ
authors.lastname: Villanueva
authors.forename: L
authors.initials: L
authors.lastname: Franch
authors.forename: C
authors.initials: C
authors.lastname: Ivorra
authors.forename: E
authors.initials: E
authors.lastname: Poch
authors.forename: X
authors.initials: X
authors.lastname: Agirre
authors.forename: F
authors.initials: F
authors.lastname: Prosper
authors.forename: I
authors.initials: I
authors.lastname: Pérez-Roger
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D001549:Benzamides; D001897:Boronic Acids / Q000494:pharmacology*; D000069286:Bortezomib; D020169:Caspases / Q000378:metabolism*; D048708:Cell Growth Processes / Q000187:drug effects; D045744:Cell Line, Tumor; D024202:Electrophoretic Mobility Shift Assay; D005434:Flow Cytometry; D016044:Fusion Proteins, bcr-abl / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology*; D011719:Pyrazines / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D016160:Retinoblastoma Protein / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D001897:Boronic Acids; D016328:NF-kappa B; D010879:Piperazines; D011719:Pyrazines; D011743:Pyrimidines; D016160:Retinoblastoma Protein; D000069286:Bortezomib; D000068877:Imatinib Mesylate; D016044:Fusion Proteins, bcr-abl; D020169:Caspases