The anti-allodynic alpha(2)delta ligand pregabalin inhibits the trafficking of the calcium channel alpha(2)delta-1 subunit to presynaptic terminals in vivo.
Bauer
Claudia S
CS
Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK. c.bauer@ucl.ac.uk
Rahman
Wahida
W
Tran-van-Minh
Alexandra
A
Lujan
Rafael
R
Dickenson
Anthony H
AH
Dolphin
Annette C
AC
D000588:Amines / Q000494:pharmacology / Q000627:therapeutic use; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D015220:Calcium Channels / Q000378:metabolism* / Q000502:physiology; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology / Q000627:therapeutic use; D000077206:Gabapentin; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D009437:Neuralgia / Q000188:drug therapy; D000069583:Pregabalin; D017729:Presynaptic Terminals / Q000187:drug effects* / Q000378:metabolism*; D021381:Protein Transport / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use
D000588:Amines; D000700:Analgesics; C425903:CACNA2D1 protein, human; D015220:Calcium Channels; D003509:Cyclohexanecarboxylic Acids; D008024:Ligands; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin