(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment.
Kakinuma
Hiroyuki
H
MedicinalChemistry Laboratories, Taisho Pharmaceutical Co., Ltd. 1-403 Yoshino-cho, Kita-ku, Saitama-shi, Saitama 331-9530, Japan. hiroyuki.kakinuma@po.rd.taisho.co.jp
Oi
Takahiro
T
Hashimoto-Tsuchiya
Yuko
Y
Arai
Masayuki
M
Kawakita
Yasunori
Y
Fukasawa
Yoshiki
Y
Iida
Izumi
I
Hagima
Naoko
N
Takeuchi
Hiroyuki
H
Chino
Yukihiro
Y
Asami
Jun
J
Okumura-Kitajima
Lisa
L
Io
Fusayo
F
Yamamoto
Daisuke
D
Miyata
Noriyuki
N
Takahashi
Teisuke
T
Uchida
Saeko
S
Yamamoto
Koji
K
D000818:Animals; D001682:Biological Availability; D001798:Blood Proteins / Q000378:metabolism; D016466:CHO Cells; D018938:Caco-2 Cells; D002463:Cell Membrane Permeability; D006224:Cricetinae; D003412:Cricetulus; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004285:Dogs; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D011924:Rats, Zucker; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D013012:Sorbitol / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
D001798:Blood Proteins; D007004:Hypoglycemic Agents; C089180:SLC5A2 protein, human; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D013012:Sorbitol; C549343:1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol