Osteoblastic differentiation of human and equine adult bone marrow-derived mesenchymal stem cells when BMP-2 or BMP-7 homodimer genetic modification is compared to BMP-2/7 heterodimer genetic modification in the presence and absence of dexamethasone.
Carpenter
Ryan S
RS
Orthopaedic Research Center, Colorado State University, Fort Collins, Colorado 80523, USA.
Goodrich
Laurie R
LR
Frisbie
David D
DD
Kisiday
John D
JD
Carbone
Beth
B
McIlwraith
C Wayne
CW
Centeno
Christopher J
CJ
Hidaka
Chisa
C
D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D055396:Bone Morphogenetic Protein 2 / Q000235:genetics / Q000378:metabolism*; D055419:Bone Morphogenetic Protein 7 / Q000235:genetics / Q000378:metabolism*; D002454:Cell Differentiation / Q000187:drug effects*; D002478:Cells, Cultured; D050659:Core Binding Factor Alpha 1 Subunit / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D006736:Horses; D006801:Humans; D008297:Male; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D023421:Models, Animal; D010006:Osteoblasts / Q000166:cytology* / Q000378:metabolism; D015675:Osteocalcin / Q000378:metabolism; D015676:Osteonectin / Q000378:metabolism; D014161:Transduction, Genetic
D000893:Anti-Inflammatory Agents; C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D055419:Bone Morphogenetic Protein 7; D050659:Core Binding Factor Alpha 1 Subunit; D015676:Osteonectin; D015675:Osteocalcin; D003907:Dexamethasone; D000469:Alkaline Phosphatase