Mycobacterium tuberculosis induces IL-17A responses through TLR4 and dectin-1 and is critically dependent on endogenous IL-1.
van de Veerdonk
Frank L
FL
Department of Medicine, Radboud University Nijmegen Medical Center, Geert Grooteplein Zuid 8, 6525 GA Nijmegen, The Netherlands. f.veerdonk@aig.umcn.nl
Teirlinck
Anne C
AC
Kleinnijenhuis
Johanneke
J
Kullberg
Bart Jan
BJ
van Crevel
Reinout
R
van der Meer
Jos W M
JW
Joosten
Leo A B
LA
Netea
Mihai G
MG
D000818:Animals; D015496:CD4-Positive T-Lymphocytes; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D020381:Interleukin-17 / Q000096:biosynthesis* / Q000276:immunology; D037181:Lectins, C-Type; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D017472:Receptors, Interleukin-1 / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D051197:Toll-Like Receptor 4 / Q000378:metabolism*; D000099181:Dectin-1
D007375:Interleukin-1; D020381:Interleukin-17; D037181:Lectins, C-Type; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D017472:Receptors, Interleukin-1; D051197:Toll-Like Receptor 4; D000099181:Dectin-1; C495345:TLR4 protein, human