Phosphoramidates of 2'-beta-D-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism.
Mehellou
Youcef
Y
Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK.
Valente
Rocco
R
Mottram
Huw
H
Walsby
Elisabeth
E
Mills
Kenneth I
KI
Balzarini
Jan
J
McGuigan
Christopher
C
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D001086:Arabinofuranosyluracil / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D043402:Cathepsin A / Q000037:antagonists & inhibitors / Q000378:metabolism; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D015195:Drug Design; D004950:Esterases / Q000037:antagonists & inhibitors; D006801:Humans; D007202:Indicators and Reagents; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008214:Lymphocytes / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors; D011355:Prodrugs / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013552:Swine; D014780:Viruses / Q000187:drug effects
D000970:Antineoplastic Agents; D000998:Antiviral Agents; C063306:HINT1 protein, human; D007202:Indicators and Reagents; D009419:Nerve Tissue Proteins; D011355:Prodrugs; D001086:Arabinofuranosyluracil; D004950:Esterases; D043402:Cathepsin A