Kv1.3 is the exclusive voltage-gated K+ channel of platelets and megakaryocytes: roles in membrane potential, Ca2+ signalling and platelet count.
McCloskey
Conor
C
Department of Cell Physiology & Pharmacology, University of Leicester, Medical Sciences Building, University Road, LE1 9HN, UK. mpms1@le.ac.uk
Jones
Sarah
S
Amisten
Stefan
S
Snowden
Roger T
RT
Kaczmarek
Leonard K
LK
Erlinge
David
D
Goodall
Alison H
AH
Forsythe
Ian D
ID
Mahaut-Smith
Martyn P
MP
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D020013:Calcium Signaling / Q000187:drug effects / Q000502:physiology*; D048429:Cell Size; D018076:DNA, Complementary / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D066298:In Vitro Techniques; D051664:Kv1.3 Potassium Channel / Q000097:blood*; D008533:Megakaryocytes / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018408:Patch-Clamp Techniques; D010976:Platelet Count; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012604:Scorpion Venoms / Q000494:pharmacology; D015290:Second Messenger Systems / Q000502:physiology
D018076:DNA, Complementary; D051664:Kv1.3 Potassium Channel; D012604:Scorpion Venoms; C077910:margatoxin