Nitro-oleic acid inhibits firing and activates TRPV1- and TRPA1-mediated inward currents in dorsal root ganglion neurons from adult male rats.
Sculptoreanu
A
A
Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh Medical School, Pittsburgh, Pennsylvania 15261, USA. ads5@pitt.edu
Kullmann
F A
FA
Artim
D E
DE
Bazley
F A
FA
Schopfer
F
F
Woodcock
S
S
Freeman
B A
BA
de Groat
W C
WC
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D017487:Ankyrins; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D015220:Calcium Channels / Q000187:drug effects* / Q000378:metabolism; D020013:Calcium Signaling / Q000187:drug effects; D002469:Cell Separation; D004594:Electrophysiology; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects*; D007091:Image Processing, Computer-Assisted; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects*; D009569:Nitric Oxide / Q000502:physiology; D009619:Nociceptors / Q000187:drug effects; D009829:Oleic Acids / Q000494:pharmacology*; D018408:Patch-Clamp Techniques; D051381:Rats; D062687:Sodium Channel Agonists; D015222:Sodium Channels / Q000187:drug effects; D000074025:TRPA1 Cation Channel; D050052:TRPC Cation Channels; D050916:TRPV Cation Channels / Q000819:agonists* / Q000378:metabolism
C521487:10-nitro-oleic acid; D017487:Ankyrins; D000893:Anti-Inflammatory Agents; D015220:Calcium Channels; D009829:Oleic Acids; D062687:Sodium Channel Agonists; D015222:Sodium Channels; D000074025:TRPA1 Cation Channel; D050052:TRPC Cation Channels; D050916:TRPV Cation Channels; C480976:Trpa1 protein, rat; C493922:Trpv1 protein, rat; D009569:Nitric Oxide