Aging-related hyperinflammation in endotoxemia is mediated by the alpha2A-adrenoceptor and CD14/TLR4 pathways.
Leong
Jennifer
J
The Feinstein Institute for Medical Research, Manhasset, NY 11030, USA.
Zhou
Mian
M
Jacob
Asha
A
Wang
Ping
P
D000367:Age Factors; D000375:Aging; D000818:Animals; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D019446:Endotoxemia / Q000503:physiopathology*; D007249:Inflammation / Q000503:physiopathology*; D018950:Lipopolysaccharide Receptors / Q000235:genetics / Q000378:metabolism; D008070:Lipopolysaccharides / Q000633:toxicity; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D018341:Receptors, Adrenergic, alpha-2 / Q000235:genetics / Q000378:metabolism*; D018805:Sepsis / Q000503:physiopathology*; D013154:Spleen / Q000378:metabolism; D051197:Toll-Like Receptor 4 / Q000235:genetics / Q000378:metabolism
D016207:Cytokines; D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides; D012333:RNA, Messenger; D018341:Receptors, Adrenergic, alpha-2; D051197:Toll-Like Receptor 4; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4