Tomatine adjuvantation of protective immunity to a major pre-erythrocytic vaccine candidate of malaria is mediated via CD8+ T cell release of IFN-gamma.
Heal
Karen G
KG
Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK.
Taylor-Robinson
Andrew W
AW
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D002478:Cells, Cultured; D016207:Cytokines / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D007113:Immunity, Innate / Q000187:drug effects* / Q000276:immunology*; D007371:Interferon-gamma; D008288:Malaria / Q000276:immunology* / Q000517:prevention & control*; D051379:Mice; D014053:Tomatine / Q000008:administration & dosage*
D000276:Adjuvants, Immunologic; D016207:Cytokines; D014053:Tomatine; D007371:Interferon-gamma