title: Ganglioside synthase knockout in oncogene-transformed fibroblasts depletes gangliosides and impairs tumor growth.
authors.affiliation: Center for Cancer and Immunology Research, Children's National Medical Center, NW, Washington, DC 20010, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: S
authors.initials: S
authors.lastname: Yan
authors.forename: A
authors.initials: A
authors.lastname: Wondimu
authors.forename: D
authors.initials: D
authors.lastname: Bob
authors.forename: M
authors.initials: M
authors.lastname: Weiss
authors.forename: K
authors.initials: K
authors.lastname: Sliwinski
authors.forename: J
authors.initials: J
authors.lastname: Villar
authors.forename: V
authors.initials: V
authors.lastname: Notario
authors.forename: M
authors.initials: M
authors.lastname: Sutherland
authors.forename: A M
authors.initials: AM
authors.lastname: Colberg-Poley
authors.forename: S
authors.initials: S
authors.lastname: Ladisch
mesh_terms: D000818:Animals; D048708:Cell Growth Processes / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000235:genetics* / Q000378:metabolism; D002478:Cells, Cultured; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology; D005732:Gangliosides / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D016259:Genes, myc; D011905:Genes, ras; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D017350:N-Acetylgalactosaminyltransferases / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism; D009857:Oncogenes; D012799:Sialyltransferases / Q000172:deficiency* / Q000235:genetics / Q000378:metabolism
chemical_list: D005732:Gangliosides; D017350:N-Acetylgalactosaminyltransferases; C023220:(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase; D012799:Sialyltransferases; C021343:haematoside synthetase