Interferon-alpha targets JAK2V617F-positive hematopoietic progenitor cells and acts through the p38 MAPK pathway.
Lu
Min
M
Tisch Cancer Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
Zhang
Wei
W
Li
Yan
Y
Berenzon
Dmitriy
D
Wang
Xiaoli
X
Wang
Jiapeng
J
Mascarenhas
John
J
Xu
Mingjiang
M
Hoffman
Ronald
R
D018952:Antigens, CD34 / Q000276:immunology; D015153:Blotting, Western; D005434:Flow Cytometry; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology*; D016133:Polymerase Chain Reaction; D048051:p38 Mitogen-Activated Protein Kinases / Q000378:metabolism*
D018952:Antigens, CD34; D016898:Interferon-alpha; D048051:p38 Mitogen-Activated Protein Kinases