Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol.
Bonifazi
Evelyn L
EL
Departamento de Química Orgánica and UMYMFOR (CONICET-UBA), Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Pabellón 2, Ciudad Universitaria, C1428EHA Buenos Aires, Argentina.
Ríos-Luci
Carla
C
León
Leticia G
LG
Burton
Gerardo
G
Padrón
José M
JM
Misico
Rosana I
RI
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007202:Indicators and Reagents; D008055:Lipids / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D009285:Naphthoquinones / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D054876:Prenylation; D013329:Structure-Activity Relationship
C550391:5-hydroxylapachol; D000972:Antineoplastic Agents, Phytogenic; D007202:Indicators and Reagents; D008055:Lipids; D009285:Naphthoquinones; C008252:lapachol