title: Mitochondrial fragmentation and neuronal cell death in response to the Bcl-2/Bcl-x(L)/Bcl-w antagonist ABT-737.
authors.affiliation: MRC Toxicology Unit, University of Leicester, Hodgkin Building, Lancaster Road, Leicester LE1 9HN, UK. kwy1@le.ac.uk
authors.forename: Kenneth W
authors.initials: KW
authors.lastname: Young
authors.forename: Lucia G P
authors.initials: LG
authors.lastname: Piñón
authors.forename: Dalbir
authors.initials: D
authors.lastname: Dhiraj
authors.forename: Davina
authors.initials: D
authors.lastname: Twiddy
authors.forename: Marion
authors.initials: M
authors.lastname: Macfarlane
authors.forename: John
authors.initials: J
authors.lastname: Hickman
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Nicotera
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002531:Cerebellum / Q000166:cytology; D006624:Hippocampus / Q000166:cytology; D008928:Mitochondria / Q000187:drug effects* / Q000648:ultrastructure; D009474:Neurons / Q000187:drug effects* / Q000648:ultrastructure; D009596:Nitrophenols / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000037:antagonists & inhibitors*; D051381:Rats; D013449:Sulfonamides / Q000494:pharmacology*; D051020:bcl-X Protein / Q000037:antagonists & inhibitors*
chemical_list: C501332:ABT-737; C491072:Bcl2l2 protein, rat; D001713:Biphenyl Compounds; D009596:Nitrophenols; D010879:Piperazines; D019253:Proto-Oncogene Proteins c-bcl-2; D013449:Sulfonamides; D051020:bcl-X Protein