title: Design, structure-based focusing and in silico screening of combinatorial library of peptidomimetic inhibitors of Dengue virus NS2B-NS3 protease.
authors.affiliation: International Centre for Science and High Technology, UNIDO, AREA Science Park, Padriciano 99, 34012, Trieste, Italy.
authors.forename: Vladimir
authors.initials: V
authors.lastname: Frecer
authors.forename: Stanislav
authors.initials: S
authors.lastname: Miertus
mesh_terms: D000595:Amino Acid Sequence; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D003198:Computer Simulation; D003716:Dengue Virus / Q000187:drug effects* / Q000201:enzymology; D015195:Drug Design; D006801:Humans; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology; D019151:Peptide Library; D011487:Protein Conformation; D021281:Quantitative Structure-Activity Relationship; D012697:Serine Endopeptidases / Q000737:chemistry / Q000187:drug effects*; D015842:Serine Proteinase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry; D000085242:Viral Proteases
chemical_list: D000998:Antiviral Agents; D009842:Oligopeptides; D019151:Peptide Library; D012697:Serine Endopeptidases; D015842:Serine Proteinase Inhibitors; D017361:Viral Nonstructural Proteins; C080102:NS2B protein, flavivirus; C515237:benzoyl-norleucyl-lysyl-arginyl-arginal; C504449:NS3 protease, dengue virus; D000085242:Viral Proteases