title: The antinociceptive effect of a benzopyran (HP1) isolated from Hypericum polyanthemum in mice hot-plate test is blocked by naloxone.
authors.affiliation: Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
authors.forename: Juliana Schulte
authors.initials: JS
authors.lastname: Haas
authors.forename: Alice Fialho
authors.initials: AF
authors.lastname: Viana
authors.forename: Ana Paula Machado
authors.initials: AP
authors.lastname: Heckler
authors.forename: Gilsane Lino
authors.initials: GL
authors.lastname: von Poser
authors.forename: Stela Maris Kuze
authors.initials: SM
authors.lastname: Rates
mesh_terms: D019342:Acetic Acid; D000701:Analgesics, Opioid / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001578:Benzopyrans / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D020902:Hypericum / Q000737:chemistry*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: C539958:6-isobutyryl-5,7-dimethoxy-2,2-dimethyl-benzopyran; D000701:Analgesics, Opioid; D001578:Benzopyrans; D009292:Narcotic Antagonists; D010936:Plant Extracts; D009270:Naloxone; D019342:Acetic Acid