title: Chloroquine activates the p53 pathway and induces apoptosis in human glioma cells.
authors.affiliation: The Translational Neurooncology Research Group, Department of Neurosurgery, Georg-August University Göttingen, Robert-Koch-Strasse 40, 37075 Göttingen, Germany. ella.kim@med.uni-goettingen.de
authors.forename: Ella L
authors.initials: EL
authors.lastname: Kim
authors.forename: Robin
authors.initials: R
authors.lastname: Wüstenberg
authors.forename: Anne
authors.initials: A
authors.lastname: Rübsam
authors.forename: Christoph
authors.initials: C
authors.lastname: Schmitz-Salue
authors.forename: Gabriele
authors.initials: G
authors.lastname: Warnecke
authors.forename: Eva-Maria
authors.initials: EM
authors.lastname: Bücker
authors.forename: Nadine
authors.initials: N
authors.lastname: Pettkus
authors.forename: Daniel
authors.initials: D
authors.lastname: Speidel
authors.forename: Veit
authors.initials: V
authors.lastname: Rohde
authors.forename: Walter
authors.initials: W
authors.lastname: Schulz-Schaeffer
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Deppert
authors.forename: Alf
authors.initials: A
authors.lastname: Giese
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D015153:Blotting, Western; D001932:Brain Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D049109:Cell Proliferation; D002738:Chloroquine / Q000494:pharmacology*; D005910:Glioma / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D010766:Phosphorylation / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D034741:RNA, Small Interfering / Q000494:pharmacology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014158:Transcription, Genetic / Q000187:drug effects; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D000962:Antimalarials; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D016159:Tumor Suppressor Protein p53; D002738:Chloroquine