2,3,7,8-tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by upregulating expression of the metastasis marker agr2 in the hepatocarcinoma cell line HepG2.
Ambolet-Camoit
Ariane
A
INSERM UMR-S 747, 75006 Paris, France.
Bui
Linh Chi
LC
Pierre
Stéphane
S
Chevallier
Aline
A
Marchand
Alexandre
A
Coumoul
Xavier
X
Garlatti
Michèle
M
Andreau
Karine
K
Barouki
Robert
R
Aggerbeck
Martine
M
D000107:Acetylation; D006528:Carcinoma, Hepatocellular; D045744:Cell Line, Tumor; D004336:Drug Antagonism; D004347:Drug Interactions; D004785:Environmental Pollutants / Q000633:toxicity*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D022781:Hepatocytes / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms; D009088:Mucoproteins; D015513:Oncogene Proteins; D010766:Phosphorylation; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000378:metabolism; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics / Q000378:metabolism; D014162:Transfection; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
C502296:AGR2 protein, human; D004785:Environmental Pollutants; D009088:Mucoproteins; D015513:Oncogene Proteins; D000072317:Polychlorinated Dibenzodioxins; D011506:Proteins; D034741:RNA, Small Interfering; D018336:Receptors, Aryl Hydrocarbon; D016159:Tumor Suppressor Protein p53