Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spectrometry and an improved mass defect filtering technique.
Ruan
Qian
Q
Department of Biotransformation, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, New Jersey 08543, USA.
Zhu
Mingshe
M
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005978:Glutathione / Q000737:chemistry; D006801:Humans; D008862:Microsomes, Liver / Q000378:metabolism; D010975:Platelet Aggregation Inhibitors / Q000378:metabolism* / Q000633:toxicity; D051381:Rats; D021241:Spectrometry, Mass, Electrospray Ionization; D013988:Ticlopidine / Q000378:metabolism* / Q000633:toxicity
D010975:Platelet Aggregation Inhibitors; D003577:Cytochrome P-450 Enzyme System; D005978:Glutathione; D013988:Ticlopidine