title: Ayanin, a non-selective phosphodiesterase 1-4 inhibitor, effectively suppresses ovalbumin-induced airway hyperresponsiveness without affecting xylazine/ketamine-induced anesthesia.
authors.affiliation: Department of Otolaryngology, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan.
authors.forename: Fei-Peng
authors.initials: FP
authors.lastname: Lee
authors.forename: Chwen-Ming
authors.initials: CM
authors.lastname: Shih
authors.forename: Hsin-Yi
authors.initials: HY
authors.lastname: Shen
authors.forename: Chien-Ming
authors.initials: CM
authors.lastname: Chen
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Chen
authors.forename: Wun-Chang
authors.initials: WC
authors.lastname: Ko
mesh_terms: D000758:Anesthesia; D000818:Animals; D001249:Asthma / Q000188:drug therapy; D001992:Bronchoalveolar Lavage Fluid; D016207:Cytokines / Q000378:metabolism; D005260:Female; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D006967:Hypersensitivity / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D007073:Immunoglobulin E / Q000097:blood / Q000378:metabolism; D007074:Immunoglobulin G / Q000097:blood / Q000378:metabolism; D007249:Inflammation / Q000473:pathology; D007649:Ketamine / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000494:pharmacology*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism*; D012137:Respiratory System / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D014991:Xylazine / Q000494:pharmacology*
chemical_list: D016207:Cytokines; D005419:Flavonoids; D007074:Immunoglobulin G; D010726:Phosphodiesterase Inhibitors; C459623:ayanin; D014991:Xylazine; D007073:Immunoglobulin E; D007649:Ketamine; D010047:Ovalbumin; D010727:Phosphoric Diester Hydrolases