title: Phosphoramidates of 2'-beta-D-arabinouridine (AraU) as phosphate prodrugs; design, synthesis, in vitro activity and metabolism.
authors.affiliation: Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3NB, UK.
authors.forename: Youcef
authors.initials: Y
authors.lastname: Mehellou
authors.forename: Rocco
authors.initials: R
authors.lastname: Valente
authors.forename: Huw
authors.initials: H
authors.lastname: Mottram
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Walsby
authors.forename: Kenneth I
authors.initials: KI
authors.lastname: Mills
authors.forename: Jan
authors.initials: J
authors.lastname: Balzarini
authors.forename: Christopher
authors.initials: C
authors.lastname: McGuigan
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D001086:Arabinofuranosyluracil / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D043402:Cathepsin A / Q000037:antagonists & inhibitors / Q000378:metabolism; D045744:Cell Line, Tumor; D002855:Chromatography, Thin Layer; D015195:Drug Design; D004950:Esterases / Q000037:antagonists & inhibitors; D006801:Humans; D007202:Indicators and Reagents; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008214:Lymphocytes / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009419:Nerve Tissue Proteins / Q000037:antagonists & inhibitors; D011355:Prodrugs / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013552:Swine; D014780:Viruses / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; C063306:HINT1 protein, human; D007202:Indicators and Reagents; D009419:Nerve Tissue Proteins; D011355:Prodrugs; D001086:Arabinofuranosyluracil; D004950:Esterases; D043402:Cathepsin A