Chromene-3-carboxamide derivatives discovered from virtual screening as potent inhibitors of the tumour maker, AKR1B10.
Endo
Satoshi
S
Laboratory of Biochemistry, Gifu Pharmaceutical University, Gifu 501-1196, Japan. sendo@gifu-pu.ac.jp
Matsunaga
Toshiyuki
T
Kuwata
Kazuo
K
Zhao
Hai-Tao
HT
El-Kabbani
Ossama
O
Kitade
Yukio
Y
Hara
Akira
A
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000447:Aldehydes / Q000378:metabolism; D000074408:Aldo-Keto Reductases; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000494:pharmacology*; D014408:Biomarkers, Tumor / Q000037:antagonists & inhibitors*; D020134:Catalytic Domain; D003198:Computer Simulation; D016208:Databases, Factual; D055808:Drug Discovery; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D005204:Farnesol / Q000031:analogs & derivatives / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D011485:Protein Binding; D011994:Recombinant Proteins / Q000737:chemistry; D013379:Substrate Specificity
D000447:Aldehydes; D000970:Antineoplastic Agents; D001578:Benzopyrans; D014408:Biomarkers, Tumor; D004791:Enzyme Inhibitors; D011994:Recombinant Proteins; D005204:Farnesol; C120471:AKR1B10 protein, human; D000074408:Aldo-Keto Reductases; D000449:Aldehyde Reductase; C027576:4-hydroxy-2-nonenal; C084519:farnesal