Rem, a member of the RGK GTPases, inhibits recombinant CaV1.2 channels using multiple mechanisms that require distinct conformations of the GTPase.
Yang
Tingting
T
Department of Physiology and Cellular Biophysics, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA.
Xu
Xianghua
X
Kernan
Timothy
T
Wu
Vincent
V
Colecraft
Henry M
HM
D000255:Adenosine Triphosphate / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D020746:Calcium Channels, L-Type / Q000187:drug effects* / Q000235:genetics; D002460:Cell Line; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000096:biosynthesis / Q000235:genetics; D003627:Data Interpretation, Statistical; D004594:Electrophysiology; D004705:Endocytosis / Q000187:drug effects; D005434:Flow Cytometry; D020558:GTP Phosphohydrolases / Q000737:chemistry* / Q000235:genetics / Q000494:pharmacology*; D006801:Humans; D018613:Microscopy, Confocal; D009705:Nucleosides / Q000378:metabolism; D017354:Point Mutation; D011487:Protein Conformation; D011994:Recombinant Proteins; D014162:Transfection
D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D018076:DNA, Complementary; C419385:L-type calcium channel alpha(1C); D009705:Nucleosides; D011994:Recombinant Proteins; D000255:Adenosine Triphosphate; D020558:GTP Phosphohydrolases