title: Novel 8-(furan-2-yl)-3-substituted thiazolo [5,4-e][1,2,4] triazolo[1,5-c] pyrimidine-2(3H)-thione derivatives as potential adenosine A(2A) receptor antagonists.
authors.affiliation: Medicinal Chemistry Division, Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, North Campus, Mall Road, Delhi 110 007, India.
authors.forename: Chandra Bhushan
authors.initials: CB
authors.lastname: Mishra
authors.forename: Sandeep Kumar
authors.initials: SK
authors.lastname: Barodia
authors.forename: Amresh
authors.initials: A
authors.lastname: Prakash
authors.forename: J B
authors.initials: JB
authors.lastname: Senthil Kumar
authors.forename: Pratibha Mehta
authors.initials: PM
authors.lastname: Luthra
mesh_terms: D058917:Adenosine A2 Receptor Antagonists; D000818:Animals; D014150:Antipsychotic Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced / Q000517:prevention & control; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002855:Chromatography, Thin Layer; D003198:Computer Simulation; D018360:Crystallography, X-Ray; D000242:Cyclic AMP / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D004409:Dyskinesia, Drug-Induced / Q000517:prevention & control; D006220:Haloperidol / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008958:Models, Molecular; D009043:Motor Activity / Q000187:drug effects; D011485:Protein Binding; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011869:Radioligand Assay; D013329:Structure-Activity Relationship; D013871:Thiones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: C550371:8-(furan-2-yl)-3-thiazolo (5,4-e)(1,2,4)triazolo(1,5-c)pyrimidine-2(3H)-thione; D058917:Adenosine A2 Receptor Antagonists; D014150:Antipsychotic Agents; D011743:Pyrimidines; D013871:Thiones; D000242:Cyclic AMP; D006220:Haloperidol