title: Lymph node-resident lymphatic endothelial cells mediate peripheral tolerance via Aire-independent direct antigen presentation.
authors.affiliation: Department of Microbiology and Carter Immunology Center, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.
authors.forename: Jarish N
authors.initials: JN
authors.lastname: Cohen
authors.forename: Cynthia J
authors.initials: CJ
authors.lastname: Guidi
authors.forename: Eric F
authors.initials: EF
authors.lastname: Tewalt
authors.forename: Hui
authors.initials: H
authors.lastname: Qiao
authors.forename: Sherin J
authors.initials: SJ
authors.lastname: Rouhani
authors.forename: Alanna
authors.initials: A
authors.lastname: Ruddell
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Farr
authors.forename: Kenneth S
authors.initials: KS
authors.lastname: Tung
authors.forename: Victor H
authors.initials: VH
authors.lastname: Engelhard
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000235:genetics; D001324:Autoantigens / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D049109:Cell Proliferation; D042783:Endothelial Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D018984:Epitopes, T-Lymphocyte / Q000276:immunology / Q000378:metabolism; D015870:Gene Expression / Q000235:genetics / Q000276:immunology; D005968:Glutamate Decarboxylase / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D007108:Immune Tolerance / Q000276:immunology*; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000166:cytology* / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D058965:MART-1 Antigen; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D008822:Mice, Transgenic; D014442:Monophenol Monooxygenase / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D009363:Neoplasm Proteins / Q000235:genetics; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology; D017154:Stromal Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology; D014157:Transcription Factors / Q000235:genetics*; D000096927:AIRE Protein; D000098853:Podoplanin
chemical_list: D000951:Antigens, Neoplasm; D001324:Autoantigens; D018984:Epitopes, T-Lymphocyte; D005968:Glutamate Decarboxylase; D015395:Histocompatibility Antigens Class I; D058965:MART-1 Antigen; D008562:Membrane Glycoproteins; D014442:Monophenol Monooxygenase; D009363:Neoplasm Proteins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D011948:Receptors, Antigen, T-Cell; D014157:Transcription Factors; D000096927:AIRE Protein; C490441:Pdpn protein, mouse; D000098853:Podoplanin; C504395:Gpa33 protein, mouse; C548668:Mlana protein, mouse; C402565:glutamate decarboxylase 1