A prostacyclin analogue, iloprost, protects from bleomycin-induced pulmonary fibrosis in mice.
Zhu
Yuanjue
Y
Department of Respiratory Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Liu
Yong
Y
Zhou
Weixun
W
Xiang
Ruolan
R
Jiang
Lei
L
Huang
Kewu
K
Xiao
Yu
Y
Guo
Zijian
Z
Gao
Jinming
J
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000378:metabolism; D001761:Bleomycin; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology / Q000276:immunology; D016207:Cytokines / Q000235:genetics / Q000378:metabolism; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D006909:Hydroxyproline / Q000378:metabolism; D016285:Iloprost / Q000008:administration & dosage / Q000494:pharmacology*; D018836:Inflammation Mediators / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008168:Lung / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008170:Lung Compliance; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011014:Pneumonia / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D015431:Weight Loss
D000893:Anti-Inflammatory Agents; D016207:Cytokines; D018836:Inflammation Mediators; D001761:Bleomycin; D016718:Arachidonic Acid; D016285:Iloprost; D006909:Hydroxyproline