title: Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication.
authors.affiliation: Genzyme Corp., 153 Second Avenue, Waltham, Massachusetts 02451, USA. renato.skerlj@genzyme.com
authors.forename: Renato T
authors.initials: RT
authors.lastname: Skerlj
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Bridger
authors.forename: Al
authors.initials: A
authors.lastname: Kaller
authors.forename: Ernest J
authors.initials: EJ
authors.lastname: McEachern
authors.forename: Jason B
authors.initials: JB
authors.lastname: Crawford
authors.forename: Yuanxi
authors.initials: Y
authors.lastname: Zhou
authors.forename: Bem
authors.initials: B
authors.lastname: Atsma
authors.forename: Jonathon
authors.initials: J
authors.lastname: Langille
authors.forename: Susan
authors.initials: S
authors.lastname: Nan
authors.forename: Duane
authors.initials: D
authors.lastname: Veale
authors.forename: Trevor
authors.initials: T
authors.lastname: Wilson
authors.forename: Curtis
authors.initials: C
authors.lastname: Harwig
authors.forename: Sigrid
authors.initials: S
authors.lastname: Hatse
authors.forename: Katrien
authors.initials: K
authors.lastname: Princen
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
authors.forename: Dominique
authors.initials: D
authors.lastname: Schols
mesh_terms: D000284:Administration, Oral; D000634:Aminoquinolines; D000818:Animals; D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001562:Benzimidazoles; D001682:Biological Availability; D002082:Butylamines; D002118:Calcium / Q000378:metabolism; D002460:Cell Line; D002463:Cell Membrane Permeability; D004285:Dogs; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism / Q000821:virology; D011869:Radioligand Assay; D051381:Rats; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000634:Aminoquinolines; D019380:Anti-HIV Agents; D001562:Benzimidazoles; D002082:Butylamines; D006573:Heterocyclic Compounds, 1-Ring; D019718:Receptors, CXCR4; C494414:mavorixafor; D002118:Calcium