Allosteric drug discrimination is coupled to mechanochemical changes in the kinesin-5 motor core.
Kim
Elizabeth D
ED
Department of Biochemistry and Molecular Biology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA.
Buckley
Rebecca
R
Learman
Sarah
S
Richard
Jessica
J
Parke
Courtney
C
Worthylake
David K
DK
Wojcik
Edward J
EJ
Walker
Richard A
RA
Kim
Sunyoung
S
D000495:Allosteric Site; D018360:Crystallography, X-Ray / Q000379:methods; D006801:Humans; D006860:Hydrogen Bonding; D016547:Kinesins / Q000737:chemistry*; D008024:Ligands; D008938:Mitosis; D009218:Myosins / Q000737:chemistry; D004364:Pharmaceutical Preparations / Q000737:chemistry; D011485:Protein Binding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D006180:Proton-Translocating ATPases / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared
C470243:KIF11 protein, human; D008024:Ligands; D004364:Pharmaceutical Preparations; D006180:Proton-Translocating ATPases; D009218:Myosins; D016547:Kinesins