title: Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats.
authors.affiliation: Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA. aaron.trask@nationwidechildrens.org
authors.forename: Aaron J
authors.initials: AJ
authors.lastname: Trask
authors.forename: Leanne
authors.initials: L
authors.lastname: Groban
authors.forename: Brian M
authors.initials: BM
authors.lastname: Westwood
authors.forename: Jasmina
authors.initials: J
authors.lastname: Varagic
authors.forename: Detlev
authors.initials: D
authors.lastname: Ganten
authors.forename: Patricia E
authors.initials: PE
authors.lastname: Gallagher
authors.forename: Mark C
authors.initials: MC
authors.lastname: Chappell
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Ferrario
mesh_terms: D000803:Angiotensin I / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D000085962:Angiotensin-Converting Enzyme 2; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006332:Cardiomegaly / Q000503:physiopathology*; D005355:Fibrosis / Q000209:etiology / Q000473:pathology*; D006352:Heart Ventricles / Q000187:drug effects / Q000201:enzymology; D007093:Imidazoles / Q000494:pharmacology*; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D010446:Peptide Fragments / Q000097:blood; D007703:Peptidyl-Dipeptidase A / Q000187:drug effects*; D051381:Rats; D055647:Rats, Transgenic
chemical_list: C486469:2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)ethylamino)-4-methylpentanoic acid; D000806:Angiotensin-Converting Enzyme Inhibitors; D007093:Imidazoles; D010446:Peptide Fragments; D000804:Angiotensin II; D000803:Angiotensin I; D007703:Peptidyl-Dipeptidase A; C000705329:Ace2 protein, rat; D000085962:Angiotensin-Converting Enzyme 2; D007930:Leucine; C118790:angiotensin I (1-7)