Stereo-specific synthesis of analogs of nerve agents and their utilization for selection and characterization of paraoxonase (PON1) catalytic scavengers.
Ashani
Y
Y
Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel.
Gupta
R D
RD
Goldsmith
M
M
Silman
I
I
Sussman
J L
JL
Tawfik
D S
DS
Leader
H
H
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D000931:Antidotes / Q000378:metabolism* / Q000494:pharmacology; D043303:Aryldialkylphosphatase / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D055162:Biocatalysis; D002619:Chemical Warfare Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D003374:Coumarins / Q000737:chemistry; D019020:Directed Molecular Evolution; D005434:Flow Cytometry; D005456:Fluorescent Dyes / Q000737:chemistry; D005459:Fluorides / Q000737:chemistry; D014644:Genetic Variation; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D006868:Hydrolysis; D055620:Optical Phenomena; D013237:Stereoisomerism; D013379:Substrate Specificity
D000931:Antidotes; D002619:Chemical Warfare Agents; D002800:Cholinesterase Inhibitors; D003374:Coumarins; D005456:Fluorescent Dyes; C030123:coumarin; D000110:Acetylcholinesterase; D043303:Aryldialkylphosphatase; D005459:Fluorides