title: The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
authors.forename: Igor
authors.initials: I
authors.lastname: Vivanco
authors.forename: Daniel
authors.initials: D
authors.lastname: Rohle
authors.forename: Matthias
authors.initials: M
authors.lastname: Versele
authors.forename: Akio
authors.initials: A
authors.lastname: Iwanami
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kuga
authors.forename: Barbara
authors.initials: B
authors.lastname: Oldrini
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Tanaka
authors.forename: Julie
authors.initials: J
authors.lastname: Dang
authors.forename: Sara
authors.initials: S
authors.lastname: Kubek
authors.forename: Nicolaos
authors.initials: N
authors.lastname: Palaskas
authors.forename: Teli
authors.initials: T
authors.lastname: Hsueh
authors.forename: Michael
authors.initials: M
authors.lastname: Evans
authors.forename: David
authors.initials: D
authors.lastname: Mulholland
authors.forename: Daniel
authors.initials: D
authors.lastname: Wolle
authors.forename: Sigrid
authors.initials: S
authors.lastname: Rajasekaran
authors.forename: Ayyappan
authors.initials: A
authors.lastname: Rajasekaran
authors.forename: Linda M
authors.initials: LM
authors.lastname: Liau
authors.forename: Timothy F
authors.initials: TF
authors.lastname: Cloughesy
authors.forename: Ivan
authors.initials: I
authors.lastname: Dikic
authors.forename: Cameron
authors.initials: C
authors.lastname: Brennan
authors.forename: Hong
authors.initials: H
authors.lastname: Wu
authors.forename: Paul S
authors.initials: PS
authors.lastname: Mischel
authors.forename: Timothy
authors.initials: T
authors.lastname: Perera
authors.forename: Ingo K
authors.initials: IK
authors.lastname: Mellinghoff
mesh_terms: D000818:Animals; D017209:Apoptosis; D002460:Cell Line; D004789:Enzyme Activation; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D051059:PTEN Phosphohydrolase / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D050721:Proto-Oncogene Proteins c-cbl / Q000378:metabolism; D034622:RNA Interference; D015398:Signal Transduction / Q000187:drug effects; D054875:Ubiquitination
chemical_list: D047428:Protein Kinase Inhibitors; D050721:Proto-Oncogene Proteins c-cbl; C512478:EGFR protein, human; D066246:ErbB Receptors; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human; C487757:Pten protein, mouse; C067419:CBL protein, human