Inhibition of the PtdIns(5) kinase PIKfyve disrupts intracellular replication of Salmonella.
Kerr
Markus C
MC
Institute for Molecular Bioscience and ARC Centre of Excellence in Bioinformatics, The University of Queensland, St Lucia, Queensland, Australia.
Wang
Jack T H
JT
Castro
Natalie A
NA
Hamilton
Nicholas A
NA
Town
Liam
L
Brown
Darren L
DL
Meunier
Frederic A
FA
Brown
Nat F
NF
Stow
Jennifer L
JL
Teasdale
Rohan D
RD
D000631:Aminopyridines / Q000494:pharmacology; D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D002460:Cell Line; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism; D006575:Heterocyclic Compounds, 3-Ring / Q000494:pharmacology; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008264:Macrophages / Q000382:microbiology; D008565:Membrane Proteins / Q000378:metabolism; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010873:Pinocytosis; D034622:RNA Interference; D012486:Salmonella typhimurium / Q000254:growth & development / Q000472:pathogenicity*; D014617:Vacuoles / Q000378:metabolism; D020691:rab GTP-Binding Proteins / Q000378:metabolism; D000090802:rab7 GTP-Binding Proteins
D000631:Aminopyridines; D001426:Bacterial Proteins; D006575:Heterocyclic Compounds, 3-Ring; D008565:Membrane Proteins; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D020691:rab GTP-Binding Proteins; D000090802:rab7 GTP-Binding Proteins; C540576:6-amino-N-(3-(4-(4-morpholinyl)pyrido(3',2'-4,5)furo(3,2-d)pyrimidin-2-yl)phenyl)-3-pyridinecarboxamide; C440638:SPI-2 protein, Salmonella; C000716463:rab7 GTP-binding proteins, human