High EVI1 expression predicts outcome in younger adult patients with acute myeloid leukemia and is associated with distinct cytogenetic abnormalities.
Gröschel
Stefan
S
Erasmus University Medical Center, Department of Hematology, Dr Molewaterplein 50, 3015 GE Rotterdam, the Netherlands.
Lugthart
Sanne
S
Schlenk
Richard F
RF
Valk
Peter J M
PJ
Eiwen
Karina
K
Goudswaard
Chantal
C
van Putten
Wim J L
WJ
Kayser
Sabine
S
Verdonck
Leo F
LF
Lübbert
Michael
M
Ossenkoppele
Gert-Jan
GJ
Germing
Ulrich
U
Schmidt-Wolf
Ingo
I
Schlegelberger
Brigitte
B
Krauter
Jürgen
J
Ganser
Arnold
A
Döhner
Hartmut
H
Löwenberg
Bob
B
Döhner
Konstanze
K
Delwel
Ruud
R
D000293:Adolescent; D000328:Adult; D002880:Chromosomes, Human, Pair 11; D002897:Chromosomes, Human, Pair 7; D020732:Cytogenetic Analysis; D004268:DNA-Binding Proteins / Q000235:genetics*; D018572:Disease-Free Survival; D005060:Europe; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D020022:Genetic Predisposition to Disease; D006801:Humans; D053208:Kaplan-Meier Estimate; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D016015:Logistic Models; D000074008:MDS1 and EVI1 Complex Locus Protein; D008297:Male; D008875:Middle Aged; D009006:Monosomy; D000090243:Nucleophosmin; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D016016:Proportional Hazards Models; D011519:Proto-Oncogenes / Q000235:genetics*; D012008:Recurrence; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D033581:Stem Cell Transplantation; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics*; D014178:Translocation, Genetic; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D015854:Up-Regulation; D055815:Young Adult
D004268:DNA-Binding Proteins; D000074008:MDS1 and EVI1 Complex Locus Protein; C063575:MECOM protein, human; C000716967:NPM1 protein, human; D014157:Transcription Factors; D000090243:Nucleophosmin