Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3?
Alves
Sandro
S
Center for Neurosciences & Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.
Nascimento-Ferreira
Isabel
I
Dufour
Noëlle
N
Hassig
Raymonde
R
Auregan
Gwennaëlle
G
Nóbrega
Clévio
C
Brouillet
Emmanuel
E
Hantraye
Philippe
P
Pedroso de Lima
Maria C
MC
Déglon
Nicole
N
de Almeida
Luís Pereira
LP
D000818:Animals; D000067699:Ataxin-3; D002460:Cell Line; D004195:Disease Models, Animal; D006801:Humans; D017827:Machado-Joseph Disease / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D008297:Male; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000502:physiology; D009687:Nuclear Proteins / Q000235:genetics* / Q000502:physiology; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D012097:Repressor Proteins / Q000235:genetics* / Q000502:physiology
D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D034741:RNA, Small Interfering; D012097:Repressor Proteins; C092341:ATXN3 protein, human; D000067699:Ataxin-3; C511593:Atxn3 protein, rat