N-acetyl-L-methionyl-L-Dopa-methyl ester as a dual acting drug that relieves L-Dopa-induced oxidative toxicity.
Minelli
Alba
A
Dipartimento Medicina Sperimentale Scienze Biochimiche, Sezione Biochimica Cellulare, Università di Perugia, Via del Giochetto, 06124, Perugia, Italia. aminelli@unipg.it
Conte
Carmela
C
Prudenzi
Elvira
E
Cacciatore
Ivana
I
Cornacchia
Catia
C
Taha
Elena
E
Pinnen
Francesco
F
D000818:Animals; D000831:Animals, Newborn; D000978:Antiparkinson Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D002478:Cells, Cultured; D019610:Cytoprotection; D005260:Female; D005978:Glutathione / Q000378:metabolism; D051547:Heme Oxygenase-1 / Q000378:metabolism; D007980:Levodopa / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008636:Mesencephalon / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D018384:Oxidative Stress / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011247:Pregnancy
D000978:Antiparkinson Agents; D007980:Levodopa; D051547:Heme Oxygenase-1; D005978:Glutathione; C035420:levodopa methyl ester