Preclinical characterization of the antiviral activity of SCH 900518 (narlaprevir), a novel mechanism-based inhibitor of hepatitis C virus NS3 protease.
Tong
X
X
Department of Virology, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA. xiao.tong@spcorp.com
Arasappan
A
A
Bennett
F
F
Chase
R
R
Feld
B
B
Guo
Z
Z
Hart
A
A
Madison
V
V
Malcolm
B
B
Pichardo
J
J
Prongay
A
A
Ralston
R
R
Skelton
A
A
Xia
E
E
Zhang
R
R
Njoroge
F G
FG
D000998:Antiviral Agents / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D003521:Cyclopropanes; D004151:Dipeptides / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D055808:Drug Discovery; D004353:Drug Evaluation, Preclinical; D024882:Drug Resistance, Viral / Q000235:genetics; D005838:Genotype; D016174:Hepacivirus / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D006801:Humans; D066298:In Vitro Techniques; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage; D007700:Kinetics; D007930:Leucine / Q000031:analogs & derivatives; D009154:Mutation; D011392:Proline / Q000031:analogs & derivatives / Q000494:pharmacology; D011480:Protease Inhibitors / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D011994:Recombinant Proteins; D012093:Replicon / Q000187:drug effects; D013450:Sulfones / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D014508:Urea; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases
D000998:Antiviral Agents; D003521:Cyclopropanes; D004151:Dipeptides; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D007930:Leucine; D011392:Proline; D011480:Protease Inhibitors; D011994:Recombinant Proteins; D013450:Sulfones; D014508:Urea; D017361:Viral Nonstructural Proteins; C084422:NS3 protein, hepatitis C virus; D012697:Serine Endopeptidases; D043583:Nucleoside-Triphosphatase; D053487:DEAD-box RNA Helicases; D000085242:Viral Proteases; C552043:narlaprevir; C512204:N-(3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl)-3-(2-((((1,1-dimethylethyl)amino)carbonyl)amino)-3,3-dimethyl-1-oxobutyl)-6,6-dimethyl-3-azabicyclo(3.1.0)hexan-2-carboxamide