Intratumoral injection of interferon-α and systemic delivery of agonist anti-CD137 monoclonal antibodies synergize for immunotherapy.
Dubrot
Juan
J
CIMA and Clinica Universitaria, Universidad de Navarra, Pamplona, Spain.
Palazón
Asis
A
Alfaro
Carlos
C
Azpilikueta
Arantza
A
Ochoa
María Carmen
MC
Rouzaut
Ana
A
Martinez-Forero
Iván
I
Teijeira
Alvaro
A
Berraondo
Pedro
P
Le Bon
Agnes
A
Hervás-Stubbs
Sandra
S
Melero
Ignacio
I
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001854:Bone Marrow Cells / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004357:Drug Synergism; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D015552:Injections, Intralesional; D007274:Injections, Intraperitoneal; D016898:Interferon-alpha / Q000008:administration & dosage; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009374:Neoplasms, Experimental / Q000235:genetics / Q000473:pathology / Q000628:therapy*; D053633:Receptor, Interferon alpha-beta / Q000172:deficiency* / Q000235:genetics; D016019:Survival Analysis; D047368:Tumor Burden / Q000187:drug effects; D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9 / Q000819:agonists / Q000276:immunology
D000911:Antibodies, Monoclonal; D016898:Interferon-alpha; D053261:Tumor Necrosis Factor Receptor Superfamily, Member 9; D053633:Receptor, Interferon alpha-beta