Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling.
Edouard
Thomas
T
INSERM U563, Centre de Physiopathologie de Toulouse-Purpan, BP3028, Toulouse, F-31024, France.
Combier
Jean-Philippe
JP
Nédélec
Audrey
A
Bel-Vialar
Sophie
S
Métrich
Mélanie
M
Conte-Auriol
Francoise
F
Lyonnet
Stanislas
S
Parfait
Béatrice
B
Tauber
Maithé
M
Salles
Jean-Pierre
JP
Lezoualc'h
Frank
F
Yart
Armelle
A
Raynal
Patrick
P
D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics / Q000378:metabolism; D002478:Cells, Cultured; D002642:Chick Embryo; D004789:Enzyme Activation; D004815:Epidermal Growth Factor / Q000378:metabolism*; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000378:metabolism*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D044542:LEOPARD Syndrome / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D009154:Mutation; D032383:Myocytes, Cardiac / Q000166:cytology / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000235:genetics / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; C098587:GAB1 protein, human; D034741:RNA, Small Interfering; D011993:Recombinant Fusion Proteins; D004815:Epidermal Growth Factor; D009320:Atrial Natriuretic Factor; D019869:Phosphatidylinositol 3-Kinases; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; C000605508:Gsk3b protein, rat; D051057:Proto-Oncogene Proteins c-akt; D038362:Glycogen Synthase Kinase 3; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11