Self inhibition of phagocytosis: the affinity of 'marker of self' CD47 for SIRPalpha dictates potency of inhibition but only at low expression levels.
Tsai
Richard K
RK
Biophysical Engineering Lab, University of Pennsylvania, Philadelphia, PA 19104, USA. discher@seas.upenn.edu
Rodriguez
Pia L
PL
Discher
Dennis E
DE
D000818:Animals; D000943:Antigens, Differentiation / Q000235:genetics / Q000276:immunology*; D051928:CD47 Antigen / Q000235:genetics / Q000276:immunology*; D002460:Cell Line; D015870:Gene Expression; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000276:immunology; D051379:Mice; D010587:Phagocytosis; D011110:Polymorphism, Genetic; D011971:Receptors, Immunologic / Q000235:genetics / Q000276:immunology*
D000943:Antigens, Differentiation; D051928:CD47 Antigen; C501922:Sirpa protein, mouse; D011971:Receptors, Immunologic; C501920:SIRPA protein, human