title: Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.
authors.affiliation: Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada.
authors.forename: Bum Soo
authors.initials: BS
authors.lastname: Hong
authors.forename: Abdellah
authors.initials: A
authors.lastname: Allali-Hassani
authors.forename: Wolfram
authors.initials: W
authors.lastname: Tempel
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Finerty
authors.forename: Farrell
authors.initials: F
authors.lastname: Mackenzie
authors.forename: Svetoslav
authors.initials: S
authors.lastname: Dimov
authors.forename: Masoud
authors.initials: M
authors.lastname: Vedadi
authors.forename: Hee-Won
authors.initials: HW
authors.lastname: Park
mesh_terms: D020134:Catalytic Domain; D002797:Choline Kinase / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D018678:Cholinergic Agents / Q000737:chemistry / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000378:metabolism; D006426:Hemicholinium 3 / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007527:Isoenzymes; D013058:Mass Spectrometry; D020125:Mutation, Missense; D010766:Phosphorylation
chemical_list: D018678:Cholinergic Agents; D004791:Enzyme Inhibitors; D007527:Isoenzymes; D006426:Hemicholinium 3; C517212:CHKA protein, human; C542592:CHKB protein, human; D002797:Choline Kinase