title: Glycine transporter 1 (GlyT1) inhibitors exhibit anticonvulsant properties in the rat maximal electroshock threshold (MEST) test.
authors.affiliation: Department of Biology, Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline plc, New Frontiers Science Park, Third Ave., Harlow, Essex CM19 5AW, UK.
authors.forename: Mikhail
authors.initials: M
authors.lastname: Kalinichev
authors.forename: Kathryn R
authors.initials: KR
authors.lastname: Starr
authors.forename: Simon
authors.initials: S
authors.lastname: Teague
authors.forename: Andrea M
authors.initials: AM
authors.lastname: Bradford
authors.forename: Rod A
authors.initials: RA
authors.lastname: Porter
authors.forename: Hugh J
authors.initials: HJ
authors.lastname: Herdon
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D004597:Electroshock; D005998:Glycine / Q000378:metabolism*; D050487:Glycine Plasma Membrane Transport Proteins / Q000037:antagonists & inhibitors*; D008297:Male; D010636:Phenols / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000378:metabolism* / Q000503:physiopathology
chemical_list: C438943:2-(N-bis(2-methoxyethyl)amino)butyric acid,2',6'-dimethoxyphenyl ester hydrobromide; D000927:Anticonvulsants; D001549:Benzamides; C561922:GSK 931145; D050487:Glycine Plasma Membrane Transport Proteins; D010636:Phenols; C493266:Slc6a9 protein, rat; D005998:Glycine