Dietary phenolic acids attenuate multiple stages of protein glycation and high-glucose-stimulated proinflammatory IL-1beta activation by interfering with chromatin remodeling and transcription in monocytes.
Wu
Chi-Hao
CH
Department of Food Science and Biotechnology, National Chung-Hsing University, Taichung, Taiwan.
Yeh
Chi-Tai
CT
Shih
Ping-Hsiao
PH
Yen
Gow-Chin
GC
D001798:Blood Proteins / Q000378:metabolism*; D050882:CREB-Binding Protein / Q000378:metabolism; D002460:Cell Line; D042002:Chromatin Assembly and Disassembly / Q000187:drug effects*; D002934:Cinnamates / Q000737:chemistry / Q000378:metabolism*; D048909:Diabetes Complications / Q000517:prevention & control; D003920:Diabetes Mellitus / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D005947:Glucose / Q000633:toxicity; D006442:Glycated Hemoglobin / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006031:Glycosylation / Q000187:drug effects; D006657:Histones / Q000378:metabolism; D006801:Humans; D062385:Hydroxybenzoates / Q000737:chemistry / Q000378:metabolism*; D053583:Interleukin-1beta / Q000235:genetics / Q000378:metabolism*; D009000:Monocytes / Q000187:drug effects* / Q000378:metabolism; D016328:NF-kappa B / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D011401:Promoter Regions, Genetic / Q000187:drug effects; D011493:Protein Kinase C / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects*
D001798:Blood Proteins; D050882:CREB-Binding Protein; D002934:Cinnamates; D005947:Glucose; D006442:Glycated Hemoglobin; D017127:Glycation End Products, Advanced; D006657:Histones; D062385:Hydroxybenzoates; D053583:Interleukin-1beta; D016328:NF-kappa B; D011493:Protein Kinase C; D012333:RNA, Messenger; C508585:IL1B protein, human; C517652:hemoglobin A1c protein, human; C494363:CREBBP protein, human; C017616:phenolic acid