A prochelator activated by beta-secretase inhibits Abeta aggregation and suppresses copper-induced reactive oxygen species formation.
Folk
Drew S
DS
Department of Chemistry, Duke University, P.O. Box 90346, Durham, North Carolina 27708, USA.
Franz
Katherine J
KJ
D053829:Amyloid Precursor Protein Secretases / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D002614:Chelating Agents / Q000378:metabolism* / Q000494:pharmacology*; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D009942:Organometallic Compounds / Q000378:metabolism / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013329:Structure-Activity Relationship
D016229:Amyloid beta-Peptides; D002614:Chelating Agents; D009942:Organometallic Compounds; D017382:Reactive Oxygen Species; D003300:Copper; D053829:Amyloid Precursor Protein Secretases