title: A simulation-based comparison of the traditional method, Rolling-6 design and a frequentist version of the continual reassessment method with special attention to trial duration in pediatric Phase I oncology trials.
authors.affiliation: St Jude Children's Research Hospital, 332 Danny Thomas Place, MS 768, Memphis, TN 38105, United States. arzu.onar@stjude.org
authors.forename: Arzu
authors.initials: A
authors.lastname: Onar-Thomas
authors.forename: Zang
authors.initials: Z
authors.lastname: Xiong
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001830:Body Surface Area; D002648:Child; D003198:Computer Simulation; D016001:Confidence Intervals; D006801:Humans; D016015:Logistic Models; D020714:Maximum Tolerated Dose; D008495:Medical Oncology; D009369:Neoplasms / Q000188:drug therapy*; D010372:Pediatrics; D012372:ROC Curve; D012107:Research Design; D018401:Sample Size; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents