PP2A regulates tau phosphorylation directly and also indirectly via activating GSK-3beta.
Qian
Wei
W
Jiangsu Key Laboratory of Neuroregeneration, Nantong University, Nantong, Jiangsu, PR China.
Shi
Jianhua
J
Yin
Xiaomin
X
Iqbal
Khalid
K
Grundke-Iqbal
Inge
I
Gong
Cheng-Xin
CX
Liu
Fei
F
D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology*; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology; D016466:CHO Cells; D006224:Cricetinae; D003412:Cricetulus; D015536:Down-Regulation; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D066298:In Vitro Techniques; D007202:Indicators and Reagents / Q000494:pharmacology; D008055:Lipids / Q000494:pharmacology; D008297:Male; D016874:Neurofibrillary Tangles / Q000473:pathology; D010766:Phosphorylation / Q000502:physiology; D054648:Protein Phosphatase 2 / Q000235:genetics*; D051381:Rats; D017208:Rats, Wistar; D014162:Transfection; D016875:tau Proteins / Q000235:genetics* / Q000378:metabolism
D007202:Indicators and Reagents; D008055:Lipids; C086724:Lipofectamine; C054369:MAPT protein, human; D016875:tau Proteins; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; C000605508:Gsk3b protein, rat; D038362:Glycogen Synthase Kinase 3; C517189:PPP2CA protein, human; D054648:Protein Phosphatase 2