Constitutive glycogen synthase kinase-3alpha/beta activity protects against chronic beta-adrenergic remodelling of the heart.
Webb
Ian G
IG
Division of Cardiology, King's College London BHF Centre, The Rayne Institute, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, UK.
Nishino
Yasuhiro
Y
Clark
James E
JE
Murdoch
Colin
C
Walker
Simon J
SJ
Makowski
Marcus R
MR
Botnar
Rene M
RM
Redwood
Simon R
SR
Shah
Ajay M
AM
Marber
Michael S
MS
D000318:Adrenergic beta-Agonists; D000367:Age Factors; D000818:Animals; D017209:Apoptosis; D006332:Cardiomegaly / Q000139:chemically induced / Q000201:enzymology* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D004789:Enzyme Activation; D005355:Fibrosis; D005786:Gene Expression Regulation; D005838:Genotype; D038362:Glycogen Synthase Kinase 3 / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D000071679:Glycogen Synthase Kinase 3 beta; D006339:Heart Rate; D007545:Isoproterenol; D051379:Mice; D008822:Mice, Transgenic; D009200:Myocardial Contraction; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology; D010641:Phenotype; D010766:Phosphorylation; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D013318:Stroke Volume; D016276:Ventricular Function; D020257:Ventricular Remodeling
D000318:Adrenergic beta-Agonists; D047428:Protein Kinase Inhibitors; D000071679:Glycogen Synthase Kinase 3 beta; C000605507:Gsk3b protein, mouse; D038362:Glycogen Synthase Kinase 3; C448021:glycogen synthase kinase 3 alpha; D007545:Isoproterenol