IL-29 and IFN-α regulate the expression of MxA, 2',5'-OAS and PKR genes in association with the activation of Raf-MEK-ERK and PI3K-AKT signal pathways in HepG2.2.15 cells.
Chai
Yu
Y
Department of Biochemistry and Molecular Biology, Anhui Medical University, 69 Meishan Road, Hefei, Anhui, 230032, China.
Huang
Hai-Liang
HL
Hu
Dao-Jun
DJ
Luo
Xin
X
Tao
Qian-Shan
QS
Zhang
Xiao-Ling
XL
Zhang
Sheng-Quan
SQ
D015088:2',5'-Oligoadenylate Synthetase / Q000235:genetics* / Q000378:metabolism; D002867:Chromones / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D048049:Extracellular Signal-Regulated MAP Kinases / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology; D019204:GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D056945:Hep G2 Cells; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology*; D007372:Interferons; D007378:Interleukins / Q000494:pharmacology*; D020935:MAP Kinase Signaling System / Q000187:drug effects; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism; D009025:Morpholines / Q000494:pharmacology; D064547:Myxovirus Resistance Proteins; D010766:Phosphorylation / Q000187:drug effects; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects*; D015854:Up-Regulation / Q000187:drug effects*; D019892:eIF-2 Kinase / Q000235:genetics*; D048490:raf Kinases / Q000378:metabolism; D000095022:Interferon Lambda
D015088:2',5'-Oligoadenylate Synthetase; D002867:Chromones; D048049:Extracellular Signal-Regulated MAP Kinases; D005419:Flavonoids; D019204:GTP-Binding Proteins; D016898:Interferon-alpha; D007372:Interferons; D007378:Interleukins; D020929:Mitogen-Activated Protein Kinase Kinases; D009025:Morpholines; D064547:Myxovirus Resistance Proteins; D012333:RNA, Messenger; D019892:eIF-2 Kinase; D048490:raf Kinases; C000624353:interferon-lambda, human; D000095022:Interferon Lambda; C579071:MX1 protein, human; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; C475085:OAS1 protein, human; C093973:2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one