title: Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract.
authors.affiliation: Ironwood Pharmaceuticals, Inc., 320 Bent Street, Cambridge, MA 02141, USA. abryant@ironwoodpharma.com
authors.forename: Alexander P
authors.initials: AP
authors.lastname: Bryant
authors.forename: Robert W
authors.initials: RW
authors.lastname: Busby
authors.forename: Wilmin P
authors.initials: WP
authors.lastname: Bartolini
authors.forename: Etchell A
authors.initials: EA
authors.lastname: Cordero
authors.forename: Gerhard
authors.initials: G
authors.lastname: Hannig
authors.forename: Marco M
authors.initials: MM
authors.lastname: Kessler
authors.forename: Christine M
authors.initials: CM
authors.lastname: Pierce
authors.forename: Robert M
authors.initials: RM
authors.lastname: Solinga
authors.forename: Jenny V
authors.initials: JV
authors.lastname: Tobin
authors.forename: Shalina
authors.initials: S
authors.lastname: Mahajan-Miklos
authors.forename: Mitchell B
authors.initials: MB
authors.lastname: Cohen
authors.forename: Caroline B
authors.initials: CB
authors.lastname: Kurtz
authors.forename: Mark G
authors.initials: MG
authors.lastname: Currie
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D005260:Female; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000378:metabolism; D005772:Gastrointestinal Transit / Q000187:drug effects; D006162:Guanylate Cyclase / Q000235:genetics; D007413:Intestinal Mucosa / Q000378:metabolism; D007419:Intestinal Secretions / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010455:Peptides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled; D018000:Receptors, Peptide / Q000819:agonists* / Q000235:genetics
chemical_list: D005765:Gastrointestinal Agents; D010455:Peptides; D018000:Receptors, Peptide; D006162:Guanylate Cyclase; C000613655:Gucy2c protein, mouse; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled; C523483:linaclotide