title: Tumor promotion by copper-overloading and its enhancement by excess iron accumulation involving oxidative stress responses in the early stage of a rat two-stage hepatocarcinogenesis model.
authors.affiliation: Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu-shi, Tokyo 183-8509, Japan.
authors.forename: Sayaka
authors.initials: S
authors.lastname: Mizukami
authors.forename: Ryohei
authors.initials: R
authors.lastname: Ichimura
authors.forename: Sayaka
authors.initials: S
authors.lastname: Kemmochi
authors.forename: Liyun
authors.initials: L
authors.lastname: Wang
authors.forename: Eriko
authors.initials: E
authors.lastname: Taniai
authors.forename: Kunitoshi
authors.initials: K
authors.lastname: Mitsumori
authors.forename: Makoto
authors.initials: M
authors.lastname: Shibutani
mesh_terms: D000818:Animals; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity; D003300:Copper / Q000378:metabolism*; D004052:Diethylnitrosamine / Q000633:toxicity; D005982:Glutathione Transferase / Q000378:metabolism; D007150:Immunohistochemistry; D007501:Iron / Q000378:metabolism*; D019190:Iron Overload / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology; D008297:Male; D018384:Oxidative Stress; D051381:Rats; D011916:Rats, Inbred F344; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis / Q000378:metabolism; D013997:Time Factors
chemical_list: D002273:Carcinogens; D017392:Thiobarbituric Acid Reactive Substances; D004052:Diethylnitrosamine; D003300:Copper; D007501:Iron; D005982:Glutathione Transferase