TRPA1 receptor induced relaxation of the human urethra involves TRPV1 and cannabinoid receptor mediated signals, and cyclooxygenase activation.
Weinhold
Philipp
P
Department of Urology, Ludwig-Maximilians University Hospital, Munich, Germany.
Gratzke
Christian
C
Streng
Tomi
T
Stief
Christian
C
Andersson
Karl-Erik
KE
Hedlund
Petter
P
D000171:Acrolein / Q000031:analogs & derivatives / Q000494:pharmacology; D000704:Analysis of Variance; D001120:Arginine / Q000494:pharmacology; D015220:Calcium Channels / Q000502:physiology*; D002211:Capsaicin / Q000031:analogs & derivatives / Q000494:pharmacology; D003511:Cyclohexanols / Q000494:pharmacology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007213:Indomethacin / Q000494:pharmacology; D017879:Isothiocyanates / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000502:physiology*; D043882:Receptors, Cannabinoid / Q000502:physiology*; D015398:Signal Transduction; D000074025:TRPA1 Cation Channel; D050916:TRPV Cation Channels / Q000502:physiology*; D050051:Transient Receptor Potential Channels / Q000819:agonists* / Q000502:physiology; D014521:Urethra / Q000187:drug effects*
D015220:Calcium Channels; D003511:Cyclohexanols; D017879:Isothiocyanates; D009419:Nerve Tissue Proteins; D043882:Receptors, Cannabinoid; D000074025:TRPA1 Cation Channel; C473350:TRPA1 protein, human; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; D050051:Transient Receptor Potential Channels; D000171:Acrolein; C054649:3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol; D001120:Arginine; C004471:allyl isothiocyanate; C071423:capsazepine; D002211:Capsaicin; C012843:cinnamaldehyde; D007213:Indomethacin