Heme oxygenase-1 and carbon monoxide promote neovascularization after myocardial infarction by modulating the expression of HIF-1alpha, SDF-1alpha and VEGF-B.
Lakkisto
Päivi
P
Department of Clinical Chemistry, Helsinki University Central Hospital, Haartmaninkatu, Helsinki, Finland. paivi.lakkisto@helsinki.fi
Kytö
Ville
V
Forsten
Hanna
H
Siren
Juha-Matti
JM
Segersvärd
Heli
H
Voipio-Pulkki
Liisa-Maria
LM
Laine
Mika
M
Pulkki
Kari
K
Tikkanen
Ilkka
I
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002248:Carbon Monoxide / Q000378:metabolism*; D002263:Carboxyhemoglobin / Q000235:genetics / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D054377:Chemokine CXCL12 / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D005786:Gene Expression Regulation; D051547:Heme Oxygenase-1 / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000378:metabolism*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000473:pathology; D009203:Myocardial Infarction / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000473:pathology; D018919:Neovascularization, Physiologic / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013234:Stem Cells / Q000187:drug effects / Q000473:pathology; D013997:Time Factors; D042561:Vascular Endothelial Growth Factor B / Q000378:metabolism*
D054377:Chemokine CXCL12; C497444:Hif1a protein, rat; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D012333:RNA, Messenger; D042561:Vascular Endothelial Growth Factor B; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin; D051547:Heme Oxygenase-1; D019009:Proto-Oncogene Proteins c-kit