title: Dihydrosphingosine 1-phosphate has a potent antifibrotic effect in scleroderma fibroblasts via normalization of phosphatase and tensin homolog levels.
authors.affiliation: Medical University of South Carolina, Charleston, USA.
authors.forename: Shizhong
authors.initials: S
authors.lastname: Bu
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Asano
authors.forename: Andreea
authors.initials: A
authors.lastname: Bujor
authors.forename: Kristin
authors.initials: K
authors.lastname: Highland
authors.forename: Faye
authors.initials: F
authors.lastname: Hant
authors.forename: Maria
authors.initials: M
authors.lastname: Trojanowska
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002478:Cells, Cultured; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D008297:Male; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D012595:Scleroderma, Systemic / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D015854:Up-Regulation / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; C060504:dihydrosphingosine 1-phosphate; D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human; D013110:Sphingosine