A tandem scFv-based fusion protein and its enediyne-energized analogue show intensified therapeutic efficacy against lung carcinoma xenograft in athymic mice.
Zhong
Genshen
G
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, 1# Tiantan Xili, Beijing 100050, China.
Zhang
Shenghua
S
Li
Yi
Y
Liu
Xiujun
X
Gao
Ruijuan
R
Miao
Qingfang
Q
Zhen
Yongsu
Y
D000617:Aminoglycosides / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D001059:Apoproteins / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D049109:Cell Proliferation / Q000187:drug effects; D053281:Enediynes / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D018093:Gelatinases / Q000276:immunology*; D006801:Humans; D008175:Lung Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D055806:Microvessels / Q000187:drug effects; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D057127:Single-Chain Antibodies / Q000737:chemistry / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use*; D023041:Xenograft Model Antitumor Assays
D000617:Aminoglycosides; D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D001059:Apoproteins; D053281:Enediynes; D011993:Recombinant Fusion Proteins; D057127:Single-Chain Antibodies; C058024:C 1027; D018093:Gelatinases