Melatonin protects the cytochrome P450 system through a novel antioxidant mechanism.
Letelier
María Eugenia
ME
Laboratory of Pharmacology and Toxicology, Department of Pharmacological and Toxicological Chemistry, School of Chemical and Pharmaceutical Sciences, Universidad de Chile, Santiago 8380492, Chile. mel@ciq.uchile.cl
Jara-Sandoval
José
J
Molina-Berríos
Alfredo
A
Faúndez
Mario
M
Aracena-Parks
Paula
P
Aguilera
Felipe
F
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D016166:Free Radical Scavengers / Q000378:metabolism; D008297:Male; D008550:Melatonin / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology; D010084:Oxidation-Reduction; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism
D000975:Antioxidants; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D003577:Cytochrome P-450 Enzyme System; D008550:Melatonin