title: Interferon-gamma inhibits interleukin-1beta-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis.
authors.affiliation: Section of Rheumatology, University Hospital of Wales, Cardiff and Vale NHS Trust, Cardiff, Wales, CF14 4XW, UK.
authors.forename: Charlotte E
authors.initials: CE
authors.lastname: Page
authors.forename: Shaun
authors.initials: S
authors.lastname: Smale
authors.forename: Sara M
authors.initials: SM
authors.lastname: Carty
authors.forename: Nicholas
authors.initials: N
authors.lastname: Amos
authors.forename: Sarah N
authors.initials: SN
authors.lastname: Lauder
authors.forename: Rhian M
authors.initials: RM
authors.lastname: Goodfellow
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Richards
authors.forename: Simon A
authors.initials: SA
authors.lastname: Jones
authors.forename: Nicholas
authors.initials: N
authors.lastname: Topley
authors.forename: Anwen S
authors.initials: AS
authors.lastname: Williams
mesh_terms: D000368:Aged; D000818:Animals; D000831:Animals, Newborn; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D002358:Cartilage, Articular / Q000187:drug effects* / Q000378:metabolism; D002417:Cattle; D019902:Chondrocytes / Q000187:drug effects / Q000378:metabolism; D018920:Coculture Techniques; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D053583:Interleukin-1beta / Q000378:metabolism; D008297:Male; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D008875:Middle Aged; D013583:Synovial Membrane / Q000187:drug effects / Q000378:metabolism
chemical_list: D053583:Interleukin-1beta; D007371:Interferon-gamma; D020782:Matrix Metalloproteinases