Randomized, double-blind, multicenter, placebo-controlled study evaluating the effect of aldosterone antagonism with eplerenone on ventricular remodeling in patients with mild-to-moderate heart failure and left ventricular systolic dysfunction.
Udelson
James E
JE
Tufts Medical Center, 750 Washington Street, Boston, MA 02111, USA. JUdelson@tuftsmedicalcenter.org
Feldman
Arthur M
AM
Greenberg
Barry
B
Pitt
Bertram
B
Mukherjee
Robin
R
Solomon
Henry A
HA
Konstam
Marvin A
MA
D000368:Aged; D015331:Cohort Studies; D004311:Double-Blind Method; D000077545:Eplerenone; D005260:Female; D015637:Gated Blood-Pool Imaging; D006333:Heart Failure / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011347:Procollagen / Q000097:blood; D011788:Quality of Life; D013148:Spironolactone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D013318:Stroke Volume; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology*; D020257:Ventricular Remodeling / Q000187:drug effects*
D000451:Mineralocorticoid Receptor Antagonists; D011347:Procollagen; D020097:Natriuretic Peptide, Brain; D013148:Spironolactone; D000077545:Eplerenone