title: Relations between toxicity and altered tissue distribution and urinary excretion of nicotine, cotinine, and hydroxycotinine after chronic oral administration of nicotine in rats.
authors.affiliation: Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, Seoul, Korea.
authors.forename: Ki Young
authors.initials: KY
authors.lastname: Kim
authors.forename: Young-Joo
authors.initials: YJ
authors.lastname: Lee
authors.forename: Bong Chul
authors.initials: BC
authors.lastname: Chung
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Byung Hwa
authors.initials: BH
authors.lastname: Jung
mesh_terms: D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001774:Blood Chemical Analysis; D001806:Blood Urea Nitrogen; D001921:Brain / Q000187:drug effects / Q000473:pathology; D003367:Cotinine / Q000031:analogs & derivatives / Q000652:urine*; D005731:Ganglionic Stimulants / Q000493:pharmacokinetics* / Q000633:toxicity* / Q000652:urine; D008401:Gas Chromatography-Mass Spectrometry; D005982:Glutathione Transferase / Q000097:blood; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D009538:Nicotine / Q000493:pharmacokinetics* / Q000633:toxicity* / Q000652:urine; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: D005731:Ganglionic Stimulants; C001381:hydroxycotinine; D009538:Nicotine; D005982:Glutathione Transferase; D001219:Aspartate Aminotransferases; D003367:Cotinine