Investigation into UDP-glucuronosyltransferase (UGT) enzyme kinetics of imidazole- and triazole-containing antifungal drugs in human liver microsomes and recombinant UGT enzymes.
Bourcier
Karine
K
Pfizer Global R&D, Ramsgate Rd., Sandwich, Kent CT13 9NJ, UK. karine.bourcier@pfizer.com
Hyland
Ruth
R
Kempshall
Sarah
S
Jones
Russell
R
Maximilien
Jacqueline
J
Irvine
Nicola
N
Jones
Barry
B
D000935:Antifungal Agents / Q000378:metabolism / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D020719:Glucuronides / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000276:immunology / Q000493:pharmacokinetics*; D008862:Microsomes, Liver / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity; D014230:Triazoles / Q000737:chemistry
D000935:Antifungal Agents; D020719:Glucuronides; D007093:Imidazoles; D014230:Triazoles; C038008:croconazole; D014453:Glucuronosyltransferase; C020527:tioconazole