Targeting the protein prenyltransferases efficiently reduces tumor development in mice with K-RAS-induced lung cancer.
Liu
Meng
M
Wallenberg Laboratory, Institute of Medicine, Sahlgrenska University Hospital, S-41345 Gothenburg, Sweden.
Sjogren
Anna-Karin M
AK
Karlsson
Christin
C
Ibrahim
Mohamed X
MX
Andersson
Karin M E
KM
Olofsson
Frida J
FJ
Wahlstrom
Annika M
AM
Dalin
Martin
M
Yu
Huiming
H
Chen
Zhenggang
Z
Yang
Shao H
SH
Young
Stephen G
SG
Bergo
Martin O
MO
D019883:Alkyl and Aryl Transferases / Q000235:genetics / Q000378:metabolism; D000483:Alleles; D000818:Animals; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism*; D004122:Dimethylallyltranstransferase / Q000172:deficiency / Q000378:metabolism*; D004195:Disease Models, Animal; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D008175:Lung Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology / Q000628:therapy; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics / Q000378:metabolism*
D019883:Alkyl and Aryl Transferases; C083291:geranylgeranyltransferase type-I; D004122:Dimethylallyltranstransferase; C495971:Hras protein, mouse; D016283:Proto-Oncogene Proteins p21(ras)