Improvement of dissolution and absorption properties of poorly water-soluble drug by preparing spray-dried powders with alpha-glucosyl hesperidin.
Uchiyama
Hiromasa
H
Laboratory of Pharmaceutical Engineering, Gifu Pharmaceutical University, Gifu, Japan.
Tozuka
Yuichi
Y
Imono
Masaaki
M
Takeuchi
Hirofumi
H
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003460:Crystallization; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D005480:Flurbiprofen / Q000008:administration & dosage* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics; D005960:Glucosides / Q000737:chemistry*; D006569:Hesperidin / Q000031:analogs & derivatives* / Q000737:chemistry; D007408:Intestinal Absorption; D008297:Male; D008823:Micelles; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D010316:Particle Size; D011208:Powders; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D013499:Surface Properties; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D004337:Drug Carriers; D005960:Glucosides; D008823:Micelles; D011208:Powders; D014867:Water; C487382:glucosyl hesperidin; D005480:Flurbiprofen; D006569:Hesperidin