title: Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
authors.affiliation: Neurogen Corporation, 35 Northeast Industrial Road, Branford, Connecticut 06405, USA.
authors.forename: Charles A
authors.initials: CA
authors.lastname: Blum
authors.forename: Timothy
authors.initials: T
authors.lastname: Caldwell
authors.forename: Xiaozhang
authors.initials: X
authors.lastname: Zheng
authors.forename: Rajagopal
authors.initials: R
authors.lastname: Bakthavatchalam
authors.forename: Scott
authors.initials: S
authors.lastname: Capitosti
authors.forename: Harry
authors.initials: H
authors.lastname: Brielmann
authors.forename: Stéphane
authors.initials: S
authors.lastname: De Lombaert
authors.forename: Mark T
authors.initials: MT
authors.lastname: Kershaw
authors.forename: David
authors.initials: D
authors.lastname: Matson
authors.forename: James E
authors.initials: JE
authors.lastname: Krause
authors.forename: Daniel
authors.initials: D
authors.lastname: Cortright
authors.forename: Marci
authors.initials: M
authors.lastname: Crandall
authors.forename: William J
authors.initials: WJ
authors.lastname: Martin
authors.forename: Beth Ann
authors.initials: BA
authors.lastname: Murphy
authors.forename: Susan
authors.initials: S
authors.lastname: Boyce
authors.forename: A Brian
authors.initials: AB
authors.lastname: Jones
authors.forename: Glenn
authors.initials: G
authors.lastname: Mason
authors.forename: Wayne
authors.initials: W
authors.lastname: Rycroft
authors.forename: Helen
authors.initials: H
authors.lastname: Perrett
authors.forename: Rachael
authors.initials: R
authors.lastname: Conley
authors.forename: Nicola
authors.initials: N
authors.lastname: Burnaby-Davies
authors.forename: Bertrand L
authors.initials: BL
authors.lastname: Chenard
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Hodgetts
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D001682:Biological Availability; D019556:COS Cells; D002211:Capsaicin / Q000494:pharmacology; D002522:Chlorocebus aethiops; D006358:Hot Temperature; D006801:Humans; D006930:Hyperalgesia / Q000188:drug therapy; D066298:In Vitro Techniques; D007249:Inflammation / Q000188:drug therapy; D008862:Microsomes, Liver; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D050916:TRPV Cation Channels / Q000819:agonists / Q000037:antagonists & inhibitors*
chemical_list: C549346:7-(3-(trifluoromethyl)pyridin-2-yl)-N-(5-(trifluoromethyl)pyridin-2-yl)-1,8-naphthyridin-4-amine; D000700:Analgesics; D009287:Naphthyridines; D011719:Pyrazines; D011725:Pyridines; D011743:Pyrimidines; D011799:Quinazolines; D011804:Quinolines; D050916:TRPV Cation Channels; C494482:TRPV1 protein, human; C493922:Trpv1 protein, rat; D002211:Capsaicin