24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3] controls growth plate development by inhibiting apoptosis in the reserve zone and stimulating response to 1alpha,25(OH)2D3 in hypertrophic cells.
Boyan
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BD
Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University, ATlanta, GA 30332-0363, USA. barbara.boyan@bme.gatech.edu
Hurst-Kennedy
J
J
Denison
T A
TA
Schwartz
Z
Z
D015650:24,25-Dihydroxyvitamin D 3 / Q000378:metabolism; D000818:Animals; D017209:Apoptosis; D002117:Calcitriol / Q000378:metabolism*; D053148:Caspase 3 / Q000378:metabolism; D049109:Cell Proliferation; D019902:Chondrocytes / Q000166:cytology; D004789:Enzyme Activation; D006132:Growth Plate / Q000187:drug effects / Q000378:metabolism*; D006984:Hypertrophy; D008246:Lysophospholipids / Q000378:metabolism; D008297:Male; D054467:Phospholipases A2 / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D008246:Lysophospholipids; D016159:Tumor Suppressor Protein p53; D015650:24,25-Dihydroxyvitamin D 3; D054467:Phospholipases A2; D053148:Caspase 3; D002117:Calcitriol; C032881:lysophosphatidic acid