Metabolism of carbosulfan II. Human interindividual variability in its in vitro hepatic biotransformation and the identification of the cytochrome P450 isoforms involved.
Abass
Khaled
K
Pharmacology and Toxicology Unit, Institute of Biomedicine, P.O. Box 5000, FI-90014 University of Oulu, Oulu, Finland. khaled.m.abass@gmail.com
Reponen
Petri
P
Mattila
Sampo
S
Pelkonen
Olavi
O
D000328:Adult; D001711:Biotransformation; D002219:Carbamates / Q000493:pharmacokinetics*; D002853:Chromatography, Liquid; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000378:metabolism*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D013058:Mass Spectrometry; D008862:Microsomes, Liver / Q000201:enzymology; D008875:Middle Aged; D015394:Molecular Structure
D002219:Carbamates; D007527:Isoenzymes; D003577:Cytochrome P-450 Enzyme System; C035038:carbosulfan