c-Myc controls the development of CD8alphaalpha TCRalphabeta intestinal intraepithelial lymphocytes from thymic precursors by regulating IL-15-dependent survival.
Jiang
Wei
W
Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland.
Ferrero
Isabel
I
Laurenti
Elisa
E
Trumpp
Andreas
A
MacDonald
H Robson
HR
D019264:Adoptive Transfer; D000818:Animals; D017209:Apoptosis; D016827:CD8 Antigens / Q000378:metabolism*; D018414:CD8-Positive T-Lymphocytes / Q000145:classification / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D002454:Cell Differentiation; D049109:Cell Proliferation; D002470:Cell Survival; D006801:Humans; D019409:Interleukin-15 / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008822:Mice, Transgenic; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism*; D053647:Receptors, Interleukin-15 / Q000378:metabolism; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000145:classification / Q000166:cytology / Q000276:immunology / Q000378:metabolism
D016827:CD8 Antigens; C409469:CD8 antigen, alpha chain; D019409:Interleukin-15; C489428:Myc protein, mouse; D019253:Proto-Oncogene Proteins c-bcl-2; D016271:Proto-Oncogene Proteins c-myc; D016693:Receptors, Antigen, T-Cell, alpha-beta; D053647:Receptors, Interleukin-15; D011994:Recombinant Proteins