A combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a.
Liechti
Luz Angélica
LA
Department of Pharmacology and Toxicology, University of Lausanne, 1005 Lausanne, Switzerland.
Bernèche
Simon
S
Bargeton
Benoîte
B
Iwaszkiewicz
Justyna
J
Roy
Sophie
S
Michielin
Olivier
O
Kellenberger
Stephan
S
D062565:Acid Sensing Ion Channels; D019943:Amino Acid Substitution; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015640:Ion Channel Gating / Q000502:physiology*; D008954:Models, Biological; D008958:Models, Molecular; D016297:Mutagenesis, Site-Directed; D020125:Mutation, Missense; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D015222:Sodium Channels / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
C568266:ASIC1 protein, human; D062565:Acid Sensing Ion Channels; D009419:Nerve Tissue Proteins; D015222:Sodium Channels