The obese phenotype-inducing N82K mutation in human leptin disrupts receptor-binding and biological activity.
Niv-Spector
Leonora
L
Institute of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel.
Shpilman
Michal
M
Grupi
Asaf
A
Gertler
Arieh
A
D019943:Amino Acid Substitution; D002648:Child; D006801:Humans; D020738:Leptin / Q000235:genetics* / Q000502:physiology*; D009765:Obesity / Q000235:genetics*; D017510:Protein Folding; D054411:Receptors, Leptin / Q000235:genetics / Q000378:metabolism*
D020738:Leptin; D054411:Receptors, Leptin