A bacterial effector targets host DH-PH domain RhoGEFs and antagonizes macrophage phagocytosis.
Dong
Na
N
College of Life Science, Peking University, Beijing, China.
Liu
Liping
L
Shao
Feng
F
D000199:Actins / Q000378:metabolism; D000818:Animals; D001427:Bacterial Toxins / Q000378:metabolism; D002460:Cell Line; D003599:Cytoskeleton / Q000378:metabolism; D004926:Escherichia coli / Q000472:pathogenicity*; D029968:Escherichia coli Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D020662:Guanine Nucleotide Exchange Factors / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D006367:HeLa Cells; D054884:Host-Pathogen Interactions; D006801:Humans; D008264:Macrophages / Q000166:cytology / Q000378:metabolism / Q000382:microbiology*; D010587:Phagocytosis; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D043562:Receptors, G-Protein-Coupled / Q000819:agonists / Q000378:metabolism; D064067:Rho Guanine Nucleotide Exchange Factors; D015398:Signal Transduction; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D000199:Actins; D001427:Bacterial Toxins; D029968:Escherichia coli Proteins; C472832:EspH protein, E coli; D020662:Guanine Nucleotide Exchange Factors; D043562:Receptors, G-Protein-Coupled; D064067:Rho Guanine Nucleotide Exchange Factors; C060296:cytotoxic necrotizing factor type 1; D020741:rho GTP-Binding Proteins