Combined antibacterial and anti-inflammatory activity of a cationic disubstituted dexamethasone-spermine conjugate.
Bucki
Robert
R
Department of Physiology and the Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA. buckirob@mail.med.upenn.edu
Leszczynska
Katarzyna
K
Byfield
Fitzroy J
FJ
Fein
David E
DE
Won
Esther
E
Cruz
Katrina
K
Namiot
Andrzej
A
Kulakowska
Alina
A
Namiot
Zbigniew
Z
Savage
Paul B
PB
Diamond
Scott L
SL
Janmey
Paul A
PA
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides; D001424:Bacterial Infections / Q000188:drug therapy; D018441:Biofilms / Q000187:drug effects; D054804:Cathelicidins / Q000737:chemistry / Q000494:pharmacology; D002417:Cattle; D002478:Cells, Cultured; D003907:Dexamethasone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D066298:In Vitro Techniques; D007378:Interleukins / Q000096:biosynthesis; D008264:Macrophages / Q000187:drug effects / Q000502:physiology; D008826:Microbial Sensitivity Tests; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011965:Receptors, Glucocorticoid / Q000187:drug effects; D013096:Spermine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D023181:Antimicrobial Cationic Peptides; D054804:Cathelicidins; D007378:Interleukins; D011965:Receptors, Glucocorticoid; D013096:Spermine; D003907:Dexamethasone