title: (1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment.
authors.affiliation: MedicinalChemistry Laboratories, Taisho Pharmaceutical Co., Ltd. 1-403 Yoshino-cho, Kita-ku, Saitama-shi, Saitama 331-9530, Japan. hiroyuki.kakinuma@po.rd.taisho.co.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kakinuma
authors.forename: Takahiro
authors.initials: T
authors.lastname: Oi
authors.forename: Yuko
authors.initials: Y
authors.lastname: Hashimoto-Tsuchiya
authors.forename: Masayuki
authors.initials: M
authors.lastname: Arai
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Kawakita
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Fukasawa
authors.forename: Izumi
authors.initials: I
authors.lastname: Iida
authors.forename: Naoko
authors.initials: N
authors.lastname: Hagima
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Chino
authors.forename: Jun
authors.initials: J
authors.lastname: Asami
authors.forename: Lisa
authors.initials: L
authors.lastname: Okumura-Kitajima
authors.forename: Fusayo
authors.initials: F
authors.lastname: Io
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamamoto
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Miyata
authors.forename: Teisuke
authors.initials: T
authors.lastname: Takahashi
authors.forename: Saeko
authors.initials: S
authors.lastname: Uchida
authors.forename: Koji
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D001682:Biological Availability; D001798:Blood Proteins / Q000378:metabolism; D016466:CHO Cells; D018938:Caco-2 Cells; D002463:Cell Membrane Permeability; D006224:Cricetinae; D003412:Cricetulus; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004285:Dogs; D022781:Hepatocytes / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D011924:Rats, Zucker; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D013012:Sorbitol / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
chemical_list: D001798:Blood Proteins; D007004:Hypoglycemic Agents; C089180:SLC5A2 protein, human; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D013012:Sorbitol; C549343:1,5-anhydro-1-(5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl)-1-thioglucitol