Adhesion of monocytes to type I collagen stimulates an APP-dependent proinflammatory signaling response and release of Abeta1-40.
Sondag
Cindy M
CM
Department of Pharmacology, Physiology & Therapeutics, University of North Dakota School of Medicine and Health Sciences, Grand Forks, ND 58203, USA.
Combs
Colin K
CK
D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000502:physiology*; D015153:Blotting, Western; D001923:Brain Chemistry / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology*; D002460:Cell Line; D002560:Cerebrovascular Circulation / Q000502:physiology; D024042:Collagen Type I / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D047468:Immunoprecipitation; D007249:Inflammation / Q000473:pathology*; D053583:Interleukin-1beta / Q000378:metabolism; D010446:Peptide Fragments / Q000378:metabolism*; D047428:Protein Kinase Inhibitors / Q000494:pharmacology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D034741:RNA, Small Interfering; D015398:Signal Transduction / Q000502:physiology*; D014162:Transfection; D048051:p38 Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D019061:src-Family Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D024042:Collagen Type I; D053583:Interleukin-1beta; D010446:Peptide Fragments; D047428:Protein Kinase Inhibitors; D034741:RNA, Small Interfering; C078592:amyloid beta-protein (1-40); D011505:Protein-Tyrosine Kinases; D019061:src-Family Kinases; D048051:p38 Mitogen-Activated Protein Kinases