Epitope distance to the target cell membrane and antigen size determine the potency of T cell-mediated lysis by BiTE antibodies specific for a large melanoma surface antigen.
Bluemel
Claudia
C
Micromet AG, Staffelseestr. 2, 81477, Munich, Germany.
Hausmann
Susanne
S
Fluhr
Petra
P
Sriskandarajah
Mirnalini
M
Stallcup
William B
WB
Baeuerle
Patrick A
PA
Kufer
Peter
P
D000818:Animals; D018033:Antibodies, Bispecific / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D000951:Antigens, Neoplasm / Q000737:chemistry / Q000276:immunology; D017252:CD3 Complex / Q000276:immunology; D016466:CHO Cells; D019496:Cancer Vaccines; D011508:Chondroitin Sulfate Proteoglycans / Q000737:chemistry / Q000276:immunology; D006224:Cricetinae; D003412:Cricetulus; D003602:Cytotoxicity, Immunologic; D018984:Epitopes, T-Lymphocyte / Q000737:chemistry / Q000276:immunology; D006801:Humans; D008545:Melanoma / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D008565:Membrane Proteins / Q000737:chemistry / Q000276:immunology; D011485:Protein Binding; D015202:Protein Engineering; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D057127:Single-Chain Antibodies / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D000099216:Chondroitin Sulfate Proteoglycan 4
D018033:Antibodies, Bispecific; D000951:Antigens, Neoplasm; D017252:CD3 Complex; D019496:Cancer Vaccines; D011508:Chondroitin Sulfate Proteoglycans; D018984:Epitopes, T-Lymphocyte; D008565:Membrane Proteins; D011993:Recombinant Fusion Proteins; D057127:Single-Chain Antibodies; C101390:CSPG4 protein, human; D000099216:Chondroitin Sulfate Proteoglycan 4