title: Chronic rapamycin treatment causes glucose intolerance and hyperlipidemia by upregulating hepatic gluconeogenesis and impairing lipid deposition in adipose tissue.
authors.affiliation: Department of Medicine, Faculty of Medicine, Cardiology Axis of the Quebec Heart and Lung Institute, and the Metabolism, Vascular and Renal Health Axis, Laval University Hospital Research Center, Laval University, Quebec, Canada.
authors.forename: Vanessa P
authors.initials: VP
authors.lastname: Houde
authors.forename: Sophie
authors.initials: S
authors.lastname: Brûlé
authors.forename: William T
authors.initials: WT
authors.lastname: Festuccia
authors.forename: Pierre-Gilles
authors.initials: PG
authors.lastname: Blanchard
authors.forename: Kerstin
authors.initials: K
authors.lastname: Bellmann
authors.forename: Yves
authors.initials: Y
authors.lastname: Deshaies
authors.forename: André
authors.initials: A
authors.lastname: Marette
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000378:metabolism; D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D015536:Down-Regulation / Q000187:drug effects; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005934:Glucagon / Q000097:blood; D018149:Glucose Intolerance / Q000139:chemically induced*; D006949:Hyperlipidemias / Q000139:chemically induced*; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007328:Insulin / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011773:Pyruvates / Q000097:blood; D012313:RNA / Q000235:genetics / Q000302:isolation & purification; D051381:Rats; D017207:Rats, Sprague-Dawley; D020123:Sirolimus / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D005230:Fatty Acids, Nonesterified; D007166:Immunosuppressive Agents; D007328:Insulin; D011773:Pyruvates; D014280:Triglycerides; D012313:RNA; D005934:Glucagon; D020123:Sirolimus