title: The L-, N-, and T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family.
authors.affiliation: Drug Discovery Research Laboratories, Kyowa Hakko Kirin Co., Ltd., Sunto-gun, Shizuoka, Japan.
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Kosaka
authors.forename: Kazunori
authors.initials: K
authors.lastname: Hirayama
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Yoda
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Sasaki
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kitayama
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kusaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Matsubara
mesh_terms: D000450:Aldosterone / Q000494:pharmacology; D001665:Binding Sites; D002121:Calcium Channel Blockers / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D020746:Calcium Channels, L-Type / Q000378:metabolism; D020864:Calcium Channels, N-Type / Q000378:metabolism; D020747:Calcium Channels, T-Type / Q000378:metabolism; D002460:Cell Line; D004095:Dihydropyridines / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000077545:Eplerenone; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists; D008958:Models, Molecular; D008968:Molecular Conformation; D009154:Mutation; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology; D018161:Receptors, Mineralocorticoid / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D013148:Spironolactone / Q000031:analogs & derivatives / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D002121:Calcium Channel Blockers; D020746:Calcium Channels, L-Type; D020864:Calcium Channels, N-Type; D020747:Calcium Channels, T-Type; D004095:Dihydropyridines; D000451:Mineralocorticoid Receptor Antagonists; D011725:Pyridines; D018161:Receptors, Mineralocorticoid; D013148:Spironolactone; D000450:Aldosterone; C061004:benidipine; D000077545:Eplerenone