Antitransgene rejection responses contribute to attenuated persistence of adoptively transferred CD20/CD19-specific chimeric antigen receptor redirected T cells in humans.
Jensen
Michael C
MC
Department of Cancer Immunotherapeutics and Tumor Immunology, Beckman Research Institute, City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010-3000, USA. mjensen@coh.org
Popplewell
Leslie
L
Cooper
Laurence J
LJ
DiGiusto
David
D
Kalos
Michael
M
Ostberg
Julie R
JR
Forman
Stephen J
SJ
D019264:Adoptive Transfer / Q000379:methods*; D018941:Antigens, CD19 / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D018951:Antigens, CD20 / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000628:therapy*; D008224:Lymphoma, Follicular / Q000276:immunology / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000276:immunology / Q000628:therapy; D011948:Receptors, Antigen, T-Cell / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000502:physiology / Q000637:transplantation*; D014162:Transfection; D019076:Transgenes / Q000276:immunology*
D018941:Antigens, CD19; D018951:Antigens, CD20; D011948:Receptors, Antigen, T-Cell