Glucocorticoid-dependent expression of O(6)-methylguanine-DNA methyltransferase gene modulates dacarbazine-induced hepatotoxicity in mice.
Horiguchi
Michiko
M
Pharmaceutics Division of Clinical Pharmacy, Department of Medico-Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Kyushu University, Higashi-ku, Fukuoka, Japan.
Kim
Jahye
J
Matsunaga
Naoya
N
Kaji
Hiroaki
H
Egawa
Takashi
T
Makino
Kazutaka
K
Koyanagi
Satoru
S
Ohdo
Shigehiro
S
D000315:Adrenalectomy; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D002478:Cells, Cultured; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000517:prevention & control*; D002940:Circadian Rhythm / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D003606:Dacarbazine / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000494:pharmacology*; D006727:Hormone Antagonists / Q000494:pharmacology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015735:Mifepristone / Q000494:pharmacology; D019853:O(6)-Methylguanine-DNA Methyltransferase / Q000096:biosynthesis* / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D000970:Antineoplastic Agents; D005938:Glucocorticoids; D006727:Hormone Antagonists; D015735:Mifepristone; D003606:Dacarbazine; D019853:O(6)-Methylguanine-DNA Methyltransferase; D003345:Corticosterone