B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin.
Dillon
Stacey R
SR
Preclinical Research and Development, ZymoGenetics, Inc, 1201 Eastlake Ave East, Seattle, WA 98102, USA. dillons@zgi.com
Harder
Brandon
B
Lewis
Kenneth B
KB
Moore
Margaret D
MD
Liu
Hong
H
Bukowski
Thomas R
TR
Hamacher
Nels B
NB
Lantry
Megan M
MM
Maurer
Mark
M
Krejsa
Cecile M
CM
Ellsworth
Jeff L
JL
Pederson
Susan
S
Elkon
Keith B
KB
Wener
Mark H
MH
Dall'Era
Maria
M
Gross
Jane A
JA
D001327:Autoimmune Diseases / Q000097:blood*; D053264:B-Cell Activating Factor / Q000097:blood*; D053301:B-Cell Maturation Antigen / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D015847:Interleukin-4 / Q000494:pharmacology; D019169:Jurkat Cells; D008213:Lymphocyte Activation / Q000187:drug effects; D055503:Protein Multimerization; D011993:Recombinant Fusion Proteins / Q000494:pharmacology*; D011994:Recombinant Proteins; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13 / Q000097:blood*
D053264:B-Cell Activating Factor; D053301:B-Cell Maturation Antigen; D011993:Recombinant Fusion Proteins; D011994:Recombinant Proteins; C114631:TNFSF13 protein, human; C505719:TNFSF13B protein, human; D053300:Tumor Necrosis Factor Ligand Superfamily Member 13; D015847:Interleukin-4; C524618:TACI receptor-IgG Fc fragment fusion protein