title: 2,3,7,8-tetrachlorodibenzo-p-dioxin counteracts the p53 response to a genotoxicant by upregulating expression of the metastasis marker agr2 in the hepatocarcinoma cell line HepG2.
authors.affiliation: INSERM UMR-S 747, 75006 Paris, France.
authors.forename: Ariane
authors.initials: A
authors.lastname: Ambolet-Camoit
authors.forename: Linh Chi
authors.initials: LC
authors.lastname: Bui
authors.forename: Stéphane
authors.initials: S
authors.lastname: Pierre
authors.forename: Aline
authors.initials: A
authors.lastname: Chevallier
authors.forename: Alexandre
authors.initials: A
authors.lastname: Marchand
authors.forename: Xavier
authors.initials: X
authors.lastname: Coumoul
authors.forename: Michèle
authors.initials: M
authors.lastname: Garlatti
authors.forename: Karine
authors.initials: K
authors.lastname: Andreau
authors.forename: Robert
authors.initials: R
authors.lastname: Barouki
authors.forename: Martine
authors.initials: M
authors.lastname: Aggerbeck
mesh_terms: D000107:Acetylation; D006528:Carcinoma, Hepatocellular; D045744:Cell Line, Tumor; D004336:Drug Antagonism; D004347:Drug Interactions; D004785:Environmental Pollutants / Q000633:toxicity*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D022781:Hepatocytes / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms; D009088:Mucoproteins; D015513:Oncogene Proteins; D010766:Phosphorylation; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000378:metabolism; D018336:Receptors, Aryl Hydrocarbon / Q000235:genetics / Q000378:metabolism; D014162:Transfection; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
chemical_list: C502296:AGR2 protein, human; D004785:Environmental Pollutants; D009088:Mucoproteins; D015513:Oncogene Proteins; D000072317:Polychlorinated Dibenzodioxins; D011506:Proteins; D034741:RNA, Small Interfering; D018336:Receptors, Aryl Hydrocarbon; D016159:Tumor Suppressor Protein p53