Structures of human carbonic anhydrase II/inhibitor complexes reveal a second binding site for steroidal and nonsteroidal inhibitors.
Cozier
Gyles E
GE
Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath,Claverton Down, Bath BA2 7AY, United Kingdom.
Leese
Mathew P
MP
Lloyd
Matthew D
MD
Baker
Matthew D
MD
Thiyagarajan
Nethaji
N
Acharya
K Ravi
KR
Potter
Barry V L
BV
D001639:Bicarbonates / Q000378:metabolism; D001665:Binding Sites; D002245:Carbon Dioxide / Q000378:metabolism; D024402:Carbonic Anhydrase II / Q000037:antagonists & inhibitors / Q000737:chemistry*; D003124:Colorimetry; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D004970:Estrone / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008958:Models, Molecular; D011487:Protein Conformation
D001639:Bicarbonates; D004791:Enzyme Inhibitors; D002245:Carbon Dioxide; C088768:estrone-3-O-sulfamate; D004970:Estrone; D024402:Carbonic Anhydrase II