title: Functional effects of PTPN11 (SHP2) mutations causing LEOPARD syndrome on epidermal growth factor-induced phosphoinositide 3-kinase/AKT/glycogen synthase kinase 3beta signaling.
authors.affiliation: INSERM U563, Centre de Physiopathologie de Toulouse-Purpan, BP3028, Toulouse, F-31024, France.
authors.forename: Thomas
authors.initials: T
authors.lastname: Edouard
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Combier
authors.forename: Audrey
authors.initials: A
authors.lastname: Nédélec
authors.forename: Sophie
authors.initials: S
authors.lastname: Bel-Vialar
authors.forename: Mélanie
authors.initials: M
authors.lastname: Métrich
authors.forename: Francoise
authors.initials: F
authors.lastname: Conte-Auriol
authors.forename: Stanislas
authors.initials: S
authors.lastname: Lyonnet
authors.forename: Béatrice
authors.initials: B
authors.lastname: Parfait
authors.forename: Maithé
authors.initials: M
authors.lastname: Tauber
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Salles
authors.forename: Frank
authors.initials: F
authors.lastname: Lezoualc'h
authors.forename: Armelle
authors.initials: A
authors.lastname: Yart
authors.forename: Patrick
authors.initials: P
authors.lastname: Raynal
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000235:genetics / Q000378:metabolism; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000235:genetics / Q000378:metabolism; D002478:Cells, Cultured; D002642:Chick Embryo; D004789:Enzyme Activation; D004815:Epidermal Growth Factor / Q000378:metabolism*; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics / Q000378:metabolism*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D044542:LEOPARD Syndrome / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D009154:Mutation; D032383:Myocytes, Cardiac / Q000166:cytology / Q000502:physiology; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism*; D010766:Phosphorylation; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000235:genetics / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism*; D034741:RNA, Small Interfering / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C098587:GAB1 protein, human; D034741:RNA, Small Interfering; D011993:Recombinant Fusion Proteins; D004815:Epidermal Growth Factor; D009320:Atrial Natriuretic Factor; D019869:Phosphatidylinositol 3-Kinases; C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; C000605508:Gsk3b protein, rat; D051057:Proto-Oncogene Proteins c-akt; D038362:Glycogen Synthase Kinase 3; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11