Carbonic anhydrase inhibitors. The beta-carbonic anhydrases from the fungal pathogens Cryptococcus neoformans and Candida albicans are strongly inhibited by substituted-phenyl-1H-indole-5-sulfonamides.
Güzel
Ozlen
O
Istanbul University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Istanbul, Turkey.
Maresca
Alfonso
A
Hall
Rebecca A
RA
Scozzafava
Andrea
A
Mastrolorenzo
Antonio
A
Mühlschlegel
Fritz A
FA
Supuran
Claudiu T
CT
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000201:enzymology; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D002256:Carbonic Anhydrases / Q000302:isolation & purification*; D003455:Cryptococcus neoformans / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D013449:Sulfonamides / Q000737:chemistry / Q000494:pharmacology*
D000935:Antifungal Agents; D002257:Carbonic Anhydrase Inhibitors; D013449:Sulfonamides; D002256:Carbonic Anhydrases