Oral administration of ethanol with aspirin increases the concentration of salicylic acid in plasma and organs, especially the brain, in mice.
Kato
Hideaki
H
Department of Forensic Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto, Japan.
Yoshimoto
Kanji
K
Kobayashi
Masaki
M
Sakabe
Masaaki
M
Funaki
Hironao
H
Ikegaya
Hiroshi
H
D000284:Administration, Oral; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage* / Q000378:metabolism / Q000493:pharmacokinetics; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D000431:Ethanol / Q000008:administration & dosage* / Q000494:pharmacology*; D006626:Hippurates / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012459:Salicylates / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics*; D014018:Tissue Distribution / Q000187:drug effects
D006626:Hippurates; D012459:Salicylates; D000431:Ethanol; C000693:salicylurate; D001241:Aspirin