Testis dysfunction by isoproterenol is mediated by upregulating endothelin receptor A, leptin and protein kinase Cvarepsilon and is attenuated by an endothelin receptor antagonist CPU0213.
Cheng
Yu-Si
YS
Research Division of Pharmacology, China Pharmaceutical University, Nanjing 210009, China.
Dai
De-Zai
DZ
Dai
Yin
Y
D000319:Adrenergic beta-Antagonists / Q000633:toxicity*; D000818:Animals; D015153:Blotting, Western; D004359:Drug Therapy, Combination; D005640:Follicle Stimulating Hormone / Q000097:blood; D015870:Gene Expression / Q000187:drug effects; D007279:Injections, Subcutaneous; D007545:Isoproterenol / Q000633:toxicity*; D020738:Leptin / Q000378:metabolism*; D008297:Male; D010766:Phosphorylation; D051744:Protein Kinase C-epsilon / Q000235:genetics / Q000378:metabolism*; D011720:Pyrazoles / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D044022:Receptor, Endothelin A / Q000235:genetics / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012671:Seminiferous Tubules / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D013739:Testosterone / Q000097:blood; D015854:Up-Regulation / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; C513821:CPU0213; D020738:Leptin; D011720:Pyrazoles; D012333:RNA, Messenger; D044022:Receptor, Endothelin A; D013739:Testosterone; D005640:Follicle Stimulating Hormone; D051744:Protein Kinase C-epsilon; D007545:Isoproterenol