title: Two-layered dissolving microneedles for percutaneous delivery of peptide/protein drugs in rats.
authors.affiliation: Department of Pharmacokinetics, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto, 607-8412, Japan. keizo@mb.kyoto-phu.ac.jp
authors.forename: Keizo
authors.initials: K
authors.lastname: Fukushima
authors.forename: Ayaka
authors.initials: A
authors.lastname: Ise
authors.forename: Hiromi
authors.initials: H
authors.lastname: Morita
authors.forename: Ryo
authors.initials: R
authors.lastname: Hasegawa
authors.forename: Yukako
authors.initials: Y
authors.lastname: Ito
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Sugioka
authors.forename: Kanji
authors.initials: K
authors.lastname: Takada
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D003911:Dextrans / Q000737:chemistry; D016503:Drug Delivery Systems / Q000295:instrumentation*; D004355:Drug Stability; D005240:Feasibility Studies; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives / Q000737:chemistry; D019382:Human Growth Hormone / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D008297:Male; D008845:Microinjections / Q000295:instrumentation* / Q000379:methods; D018715:Microscopy, Video; D009339:Needles; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics; D012869:Skin Absorption; D012995:Solubility
chemical_list: D003911:Dextrans; D011994:Recombinant Proteins; C015219:fluorescein isothiocyanate dextran; D019382:Human Growth Hormone; D003894:Deamino Arginine Vasopressin; D016650:Fluorescein-5-isothiocyanate