title: Utility of the carboxylesterase inhibitor bis-para-nitrophenylphosphate (BNPP) in the plasma unbound fraction determination for a hydrolytically unstable amide derivative and agonist of the TGR5 receptor.
authors.affiliation: Pharmacokinetics, Dynamics and Metabolism, Groton, CT, USA.
authors.forename: H
authors.initials: H
authors.lastname: Eng
authors.forename: M
authors.initials: M
authors.lastname: Niosi
authors.forename: T S
authors.initials: TS
authors.lastname: McDonald
authors.forename: A
authors.initials: A
authors.lastname: Wolford
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: S T M
authors.initials: ST
authors.lastname: Simila
authors.forename: J N
authors.initials: JN
authors.lastname: Bauman
authors.forename: J
authors.initials: J
authors.lastname: Warmus
authors.forename: A S
authors.initials: AS
authors.lastname: Kalgutkar
mesh_terms: D000818:Animals; D043182:Carboxylesterase / Q000037:antagonists & inhibitors*; D004285:Dogs; D004355:Drug Stability; D005260:Female; D006801:Humans; D006868:Hydrolysis; D007546:Isoquinolines / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D009249:NADP / Q000494:pharmacology; D009596:Nitrophenols / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010084:Oxidation-Reduction; D011804:Quinolines / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D043562:Receptors, G-Protein-Coupled / Q000819:agonists; D014230:Triazoles / Q000494:pharmacology
chemical_list: C551632:1-(6-fluoro-2-methyl-3,4-dihydroquinolin-1(2H)-yl)-2-(isoquinolin-5-yloxy)ethanone; C473772:GPBAR1 protein, human; D007546:Isoquinolines; D009596:Nitrophenols; D009943:Organophosphorus Compounds; D011804:Quinolines; D043562:Receptors, G-Protein-Coupled; D014230:Triazoles; C033020:1-aminobenzotriazole; C008644:nitrophenylphosphate; D009249:NADP; D043182:Carboxylesterase