Dominant negative mutations affect oligomerization of human pyruvate kinase M2 isozyme and promote cellular growth and polyploidy.
Gupta
Vibhor
V
National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
Kalaiarasan
Ponnusamy
P
Faheem
Mohammad
M
Singh
Nishant
N
Iqbal
Mohammad Askandar
MA
Bamezai
Rameshwar N K
RN
D000818:Animals; D049109:Cell Proliferation; D018450:Disease Progression; D004926:Escherichia coli / Q000378:metabolism; D005434:Flow Cytometry; D005799:Genes, Dominant; D005982:Glutathione Transferase / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry; D007700:Kinetics; D009154:Mutation; D011123:Polyploidy; D011770:Pyruvate Kinase / Q000737:chemistry*; D020798:Two-Hybrid System Techniques
D007527:Isoenzymes; D005982:Glutathione Transferase; D011770:Pyruvate Kinase