Interferon-gamma inhibits interleukin-1beta-induced matrix metalloproteinase production by synovial fibroblasts and protects articular cartilage in early arthritis.
Page
Charlotte E
CE
Section of Rheumatology, University Hospital of Wales, Cardiff and Vale NHS Trust, Cardiff, Wales, CF14 4XW, UK.
Smale
Shaun
S
Carty
Sara M
SM
Amos
Nicholas
N
Lauder
Sarah N
SN
Goodfellow
Rhian M
RM
Richards
Peter J
PJ
Jones
Simon A
SA
Topley
Nicholas
N
Williams
Anwen S
AS
D000368:Aged; D000818:Animals; D000831:Animals, Newborn; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D002358:Cartilage, Articular / Q000187:drug effects* / Q000378:metabolism; D002417:Cattle; D019902:Chondrocytes / Q000187:drug effects / Q000378:metabolism; D018920:Coculture Techniques; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D053583:Interleukin-1beta / Q000378:metabolism; D008297:Male; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D008875:Middle Aged; D013583:Synovial Membrane / Q000187:drug effects / Q000378:metabolism
D053583:Interleukin-1beta; D007371:Interferon-gamma; D020782:Matrix Metalloproteinases