Oxidative biotransformation of fatty acids by cytochromes P450: predicted key structural elements orchestrating substrate specificity, regioselectivity and catalytic efficiency.
Hlavica
Peter
P
Walther-Straub-Institut für Pharmakologie und Toxikologie der LMU, München, Germany. hlavica@lrz.uni-muenchen.de
Lehnerer
Michael
M
D000818:Animals; D019843:Archaeal Proteins / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D001665:Binding Sites; D001711:Biotransformation; D020134:Catalytic Domain; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005656:Fungal Proteins / Q000378:metabolism; D006801:Humans; D006900:Hydroxylation; D007527:Isoenzymes; D008958:Models, Molecular; D009154:Mutation; D010084:Oxidation-Reduction; D010940:Plant Proteins / Q000378:metabolism; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013379:Substrate Specificity
D019843:Archaeal Proteins; D001426:Bacterial Proteins; D005227:Fatty Acids; D005656:Fungal Proteins; D007527:Isoenzymes; D010940:Plant Proteins; D003577:Cytochrome P-450 Enzyme System