title: Absence of PI3Kgamma leads to increased leukocyte apoptosis and diminished severity of experimental autoimmune encephalomyelitis.
authors.affiliation: Laboratory of Immunopharmacology, Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Brazil.
authors.forename: David Henrique
authors.initials: DH
authors.lastname: Rodrigues
authors.forename: Márcia de Carvalho
authors.initials: MC
authors.lastname: Vilela
authors.forename: Lucíola da Silva
authors.initials: LS
authors.lastname: Barcelos
authors.forename: Vanessa
authors.initials: V
authors.lastname: Pinho
authors.forename: Mauro Martins
authors.initials: MM
authors.lastname: Teixeira
authors.forename: Antônio Lúcio
authors.initials: AL
authors.lastname: Teixeira
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis / Q000235:genetics / Q000276:immunology*; D015551:Autoimmunity / Q000502:physiology*; D001921:Brain / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D002448:Cell Adhesion / Q000235:genetics / Q000276:immunology; D002470:Cell Survival / Q000235:genetics / Q000276:immunology; D018925:Chemokines / Q000378:metabolism; D002634:Chemotaxis, Leukocyte / Q000235:genetics / Q000276:immunology; D058544:Class Ib Phosphatidylinositol 3-Kinase; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000235:genetics / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000201:enzymology* / Q000235:genetics / Q000276:immunology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology; D007527:Isoenzymes / Q000235:genetics / Q000378:metabolism; D007962:Leukocytes / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009103:Multiple Sclerosis / Q000201:enzymology / Q000235:genetics / Q000276:immunology; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism*
chemical_list: D018925:Chemokines; D004791:Enzyme Inhibitors; D007527:Isoenzymes; D019869:Phosphatidylinositol 3-Kinases; D058544:Class Ib Phosphatidylinositol 3-Kinase; C546764:Pik3cg protein, mouse