title: Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation.
authors.affiliation: Department of Pathology and Cell Biology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA. eh2217@columbia.edu
authors.forename: Eldad A
authors.initials: EA
authors.lastname: Hod
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Set A
authors.initials: SA
authors.lastname: Sokol
authors.forename: Boguslaw S
authors.initials: BS
authors.lastname: Wojczyk
authors.forename: Richard O
authors.initials: RO
authors.lastname: Francis
authors.forename: Daniel
authors.initials: D
authors.lastname: Ansaldi
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Francis
authors.forename: Phyllis
authors.initials: P
authors.lastname: Della-Latta
authors.forename: Susan
authors.initials: S
authors.lastname: Whittier
authors.forename: Sujit
authors.initials: S
authors.lastname: Sheth
authors.forename: Jeanne E
authors.initials: JE
authors.lastname: Hendrickson
authors.forename: James C
authors.initials: JC
authors.lastname: Zimring
authors.forename: Gary M
authors.initials: GM
authors.lastname: Brittenham
authors.forename: Steven L
authors.initials: SL
authors.lastname: Spitalnik
mesh_terms: D000210:Acute-Phase Reaction / Q000097:blood / Q000209:etiology; D000818:Animals; D001793:Blood Preservation / Q000009:adverse effects*; D003676:Deferoxamine / Q000494:pharmacology; D004195:Disease Models, Animal; D019446:Endotoxemia / Q000097:blood / Q000209:etiology; D004731:Endotoxins / Q000097:blood; D004905:Erythrocyte Aging; D017707:Erythrocyte Transfusion / Q000009:adverse effects*; D004927:Escherichia coli Infections / Q000097:blood / Q000209:etiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology* / Q000517:prevention & control; D018836:Inflammation Mediators / Q000097:blood; D007501:Iron / Q000097:blood* / Q000378:metabolism; D007502:Iron Chelating Agents / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008954:Models, Biological; D013154:Spleen / Q000378:metabolism; D013997:Time Factors
chemical_list: D004731:Endotoxins; D006454:Hemoglobins; D018836:Inflammation Mediators; D007502:Iron Chelating Agents; D007501:Iron; D003676:Deferoxamine