Mineralocorticoid receptor overexpression in embryonic stem cell-derived cardiomyocytes increases their beating frequency.
Le Menuet
Damien
D
INSERM U693, Faculté de Médecine Paris-Sud, 63, rue Gabriel Péri, 94276 Le Kremlin Bicêtre Cedex, France.
Munier
Mathilde
M
Meduri
Geri
G
Viengchareun
Say
S
Lombès
Marc
M
D000818:Animals; D020746:Calcium Channels, L-Type / Q000378:metabolism; D002454:Cell Differentiation; D002460:Cell Line; D054815:Cyclic Nucleotide-Gated Cation Channels / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000187:drug effects / Q000378:metabolism*; D006339:Heart Rate / Q000187:drug effects / Q000235:genetics; D006801:Humans; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D008564:Membrane Potentials; D051379:Mice; D008822:Mice, Transgenic; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects / Q000235:genetics; D032383:Myocytes, Cardiac / Q000187:drug effects / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism; D024661:Potassium Channels, Inwardly Rectifying / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D018161:Receptors, Mineralocorticoid / Q000235:genetics / Q000378:metabolism*; D013148:Spironolactone / Q000494:pharmacology; D013997:Time Factors; D015854:Up-Regulation
C514350:CACNA1C protein, mouse; D020746:Calcium Channels, L-Type; D054815:Cyclic Nucleotide-Gated Cation Channels; C578665:HCN1 protein, human; C578666:Hcn1 protein, mouse; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; C489457:KCNJ2 protein, human; D000451:Mineralocorticoid Receptor Antagonists; D015221:Potassium Channels; D024661:Potassium Channels, Inwardly Rectifying; D012333:RNA, Messenger; D018161:Receptors, Mineralocorticoid; D013148:Spironolactone