Identification and hit-to-lead exploration of a novel series of histamine H4 receptor inverse agonists.
Cramp
Sue
S
Argenta, 8/9 Spire Green Centre, Flex Meadow, Harlow, Essex, UK. Sue.cramp@argentadiscovery.com
Dyke
Hazel J
HJ
Higgs
Christopher
C
Clark
David E
DE
Gill
Matthew
M
Savy
Pascal
P
Jennings
Neil
N
Price
Steve
S
Lockey
Peter M
PM
Norman
Dennis
D
Porres
Soraya
S
Wilson
Francis
F
Jones
Alison
A
Ramsden
Nigel
N
Mangano
Raffaella
R
Leggate
Dan
D
Andersson
Marie
M
Hale
Richard
R
D000818:Animals; D001682:Biological Availability; D055808:Drug Discovery; D006633:Histamine Antagonists / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008252:Macaca fascicularis; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors*; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4; D013237:Stereoisomerism
D006633:Histamine Antagonists; C498828:Hrh4 protein, rat; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4