TrkB agonist antibody dose-dependently raises blood pressure in mice with diet-induced obesity.
Xu
Lingfei
L
Novartis Institutes for BioMedical Research & Novartis Pharmaceutical Company, East Hanover, New Jersey, USA.
Zhang
Yunyu
Y
Cohen
Steven B
SB
DiPetrillo
Keith
K
D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000009:adverse effects; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism*; D004032:Diet / Q000009:adverse effects; D004041:Dietary Fats / Q000008:administration & dosage / Q000009:adverse effects; D006973:Hypertension / Q000209:etiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000201:enzymology*; D010880:Piperidines / Q000008:administration & dosage; D011720:Pyrazoles / Q000008:administration & dosage; D020813:Receptor, trkB / Q000819:agonists* / Q000276:immunology; D000077285:Rimonabant; D013686:Telemetry / Q000379:methods; D015431:Weight Loss
D019440:Anti-Obesity Agents; D000911:Antibodies, Monoclonal; D019208:Brain-Derived Neurotrophic Factor; D004041:Dietary Fats; D010880:Piperidines; D011720:Pyrazoles; D020813:Receptor, trkB; D000077285:Rimonabant