Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate.
Hamada
Maiko
M
Research Division, Mitsubishi Tanabe Pharma Corporation, 1000, Kamoshida-cho, Aoba-ku, Yokohama, Kanagawa 227-0033, Japan.
Nakamura
Mitsuharu
M
Kiuchi
Masatoshi
M
Marukawa
Kaoru
K
Tomatsu
Ayumi
A
Shimano
Kyoko
K
Sato
Noriko
N
Sugahara
Kunio
K
Asayama
Mahoko
M
Takagi
Kan
K
Adachi
Kunitomo
K