title: Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor.
authors.affiliation: Cancer Research, Abbott Laboratories 100 Abbott Park Road, Abbott Park, Illinois 60064, USA. thomas.penning@abbott.com
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Penning
authors.forename: Gui-Dong
authors.initials: GD
authors.lastname: Zhu
authors.forename: Jianchun
authors.initials: J
authors.lastname: Gong
authors.forename: Sheela
authors.initials: S
authors.lastname: Thomas
authors.forename: Viraj B
authors.initials: VB
authors.lastname: Gandhi
authors.forename: Xuesong
authors.initials: X
authors.lastname: Liu
authors.forename: Yan
authors.initials: Y
authors.lastname: Shi
authors.forename: Vered
authors.initials: V
authors.lastname: Klinghofer
authors.forename: Eric F
authors.initials: EF
authors.lastname: Johnson
authors.forename: Chang H
authors.initials: CH
authors.lastname: Park
authors.forename: Elizabeth H
authors.initials: EH
authors.lastname: Fry
authors.forename: Cherrie K
authors.initials: CK
authors.lastname: Donawho
authors.forename: David J
authors.initials: DJ
authors.lastname: Frost
authors.forename: Fritz G
authors.initials: FG
authors.lastname: Buchanan
authors.forename: Gail T
authors.initials: GT
authors.lastname: Bukofzer
authors.forename: Luis E
authors.initials: LE
authors.lastname: Rodriguez
authors.forename: Velitchka
authors.initials: V
authors.lastname: Bontcheva-Diaz
authors.forename: Jennifer J
authors.initials: JJ
authors.lastname: Bouska
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Osterling
authors.forename: Amanda M
authors.initials: AM
authors.lastname: Olson
authors.forename: Kennan C
authors.initials: KC
authors.lastname: Marsh
authors.forename: Yan
authors.initials: Y
authors.lastname: Luo
authors.forename: Vincent L
authors.initials: VL
authors.lastname: Giranda