Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor.
Penning
Thomas D
TD
Cancer Research, Abbott Laboratories 100 Abbott Park Road, Abbott Park, Illinois 60064, USA. thomas.penning@abbott.com
Zhu
Gui-Dong
GD
Gong
Jianchun
J
Thomas
Sheela
S
Gandhi
Viraj B
VB
Liu
Xuesong
X
Shi
Yan
Y
Klinghofer
Vered
V
Johnson
Eric F
EF
Park
Chang H
CH
Fry
Elizabeth H
EH
Donawho
Cherrie K
CK
Frost
David J
DJ
Buchanan
Fritz G
FG
Bukofzer
Gail T
GT
Rodriguez
Luis E
LE
Bontcheva-Diaz
Velitchka
V
Bouska
Jennifer J
JJ
Osterling
Donald J
DJ
Olson
Amanda M
AM
Marsh
Kennan C
KC
Luo
Yan
Y
Giranda
Vincent L
VL