title: Invited commentary.
authors.affiliation: Department of Surgery, University of Michigan Medical School, 5144 Cardiovascular Center, SPC 5864, Ann Arbor, MI 48109-5864, USA. jhirsch@umich.edu
authors.forename: Jennifer C
authors.initials: JC
authors.lastname: Hirsch
authors.forename: Richard G
authors.initials: RG
authors.lastname: Ohye