title: MRICOM-MRI COntrast Modelling using 2D T1-T2 correlation spectra and relaxation signatures.
abstract: Image contrast is calculated by inputting experimental 2D T(1)-T(2) relaxation spectra into the ODIN software interface. The method involves characterising a magnetic resonance imaging pulse sequence with a "relaxation signature" which describes the sensitivity of the sequence to relaxation and is independent of sample parameters. Maximising (or minimising) the overlap between the experimental 2D T(1)-T(2) relaxation spectra and the relaxation signature can then be used to maximise image contrast. The concept is illustrated using relaxation signatures for the echo planar imaging and Turbo spin-echo imaging sequences, together with in-vitro 2D T(1)-T(2) spectra for liver and cartilage.
authors.affiliation: Institute of Food Research, Norwich Research Park, Colney, Norwich, UK.
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Wright
authors.forename: Joshua
authors.initials: J
authors.lastname: Warner
authors.forename: Luca
authors.initials: L
authors.lastname: Venturi
authors.forename: Robert B
authors.initials: RB
authors.lastname: Piggott
authors.forename: Simon
authors.initials: S
authors.lastname: Donell
authors.forename: Brian P
authors.initials: BP
authors.lastname: Hills
mesh_terms: D000465:Algorithms; D017352:Echo-Planar Imaging / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013223:Statistics as Topic