[Is "fibroblast" a specialized cell or a functional condition of mesenchymal cells derivatives?].
The debatable article is devoted to the analysis of consecutive changes of the notion about the origin, migration, morphofunctional heterogeneity, differentiation and proliferative potential of the basic cells of a connective tissue--fibroblasts. Despite of a plenty of an actual material on this section of cellular biology, till now there is no uniform concept about fibroblasts to a full degree defining their cytogenesis, features of phenotypic answers, and position in differon organization. In this article, the data available in literature are systematized and generalized. The modern outline of fibroblastic differon is offered for the subsequent determination of role and place of its various parts in normal physiological and pathological reactions of connective tissue.
Bozo
I Ia
IIa
Deev
R V
RV
Pinaev
G P
GP
D000818:Animals; D002454:Cell Differentiation; D002465:Cell Movement; D049109:Cell Proliferation; D005347:Fibroblasts / Q000166:cytology / Q000502:physiology*; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology*