Anticancer activity of diterpenoids from Amoora ouangliensis and Amoora stellato-squamosa.
A new ent-halimane-type diterpene, named 5(10),14-ent-halimadien-3beta,13S-diol (1), was isolated from the bark of Amoora ouangliensis and its chemical structure determined on the basis of spectroscopic analysis. Additionally, ten other diterpenoids were obtained from A. ouangliensis and A. stellato-squamosa. The bioactive experiments of all compounds against AGZY 83-a (human lung cancer cells) and SMMC-7721 (human liver cancer cells) cells were documented.
Yang
Shu-Min
SM
School of Chemical Biology and Pharmaceutical Sciences, Capital Medical University, Beijing 100069, China. xiaoyang618@yahoo.com.cn
Wu
Da-Gang
DG
Liu
Xi-Kui
XK
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000473:pathology*; D009682:Magnetic Resonance Spectroscopy; D029582:Meliaceae / Q000737:chemistry*; D008958:Models, Molecular
D000970:Antineoplastic Agents; D004224:Diterpenes; D002945:Cisplatin