Cu-free click cycloaddition reactions in chemical biology.
Bioorthogonal chemical reactions are paving the way for new innovations in biology. These reactions possess extreme selectivity and biocompatibility, such that their participating reagents can form covalent bonds within richly functionalized biological systems--in some cases, living organisms. This tutorial review will summarize the history of this emerging field, as well as recent progress in the development and application of bioorthogonal copper-free click cycloaddition reactions.
Jewett
John C
JC
Department of Chemistry, University of California, Berkeley, CA 94720, USA.
Bertozzi
Carolyn R
CR
D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D055162:Biocatalysis; D001669:Biochemical Phenomena; D003300:Copper / Q000737:chemistry; D003500:Cyclization
D000480:Alkynes; D001386:Azides; D003300:Copper