title: The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: a cohort study of 95 patients with autoimmune thyroid disorders.
abstract: Complement mannan-binding lectin (MBL) deficiency is associated with increased susceptibility to infections and autoimmune diseases. Previous studies suggested that the production of MBL is stimulated by thyroid hormones. The aim of our study was to investigate this association in patients with autoimmune thyroid diseases (AITD). Serum levels of MBL and parameters of the thyroid function were determined in 62 patients with Hashimoto's thyroiditis, 33 with Graves' disease and 47 blood donors. Follow-up measurements were performed after 6 to 24 months. MBL2 genotypes were determined using multiplex PCR and compared to 359 healthy Czech individuals. Serum levels of MBL tightly correlated with thyroid hormones, leading to strongly increased MBL levels in hyperthyroidism and decreased levels in hypothyroidism. With normalization of the thyroid function during follow-up, MBL levels decreased or increased respectively. The observed correlations were not due to MBL polymorphisms since the frequency of MBL2 polymorphisms in AITD patients was not different from the general population. We conclude that AITD are not associated with MBL polymorphisms. However, the MBL production is strongly dependent on thyroid function, regardless of the genotype.
authors.affiliation: Third Department of Medicine, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic. eliska.potlukova@seznam.cz
authors.forename: Eliska
authors.initials: E
authors.lastname: Potlukova
authors.forename: Jan
authors.initials: J
authors.lastname: Jiskra
authors.forename: Tomas
authors.initials: T
authors.lastname: Freiberger
authors.forename: Zdenka
authors.initials: Z
authors.lastname: Limanova
authors.forename: Dana
authors.initials: D
authors.lastname: Zivorova
authors.forename: Karin
authors.initials: K
authors.lastname: Malickova
authors.forename: Drahomira
authors.initials: D
authors.lastname: Springer
authors.forename: Lucie
authors.initials: L
authors.lastname: Grodecka
authors.forename: Marie
authors.initials: M
authors.lastname: Antosova
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Telicka
authors.forename: Satu Sinikka
authors.initials: SS
authors.lastname: Pesickova
authors.forename: Marten
authors.initials: M
authors.lastname: Trendelenburg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D018153:Czech Republic; D005260:Female; D005838:Genotype; D006111:Graves Disease / Q000097:blood*; D050031:Hashimoto Disease / Q000097:blood*; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood* / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D055815:Young Adult
chemical_list: C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin; D013963:Thyroid Hormones; D014284:Triiodothyronine; D013972:Thyrotropin; D002097:C-Reactive Protein; D013974:Thyroxine