title: Treadmill exercise-dependent tumor growth retardation in T-cell lymphoma-bearing host displays gender dimorphism.
abstract: A number of previous investigations have reported that physical exercise renders immunopotentiating and antitumor therapeutic benefits to the tumor-bearing host. As these effects of physical exercise are mainly mediated through the modulation of hormonal and cytokine repertoire, it remains unclear if male and female tumor-bearing hosts show a gender-dependent differential response to the therapeutic action of physical exercise in tumor growth retardation. In the present investigation tumor growth retardation, following physical exercise was investigated in a gender-specific manner in a murine tumor model of a T-cell lymphoma designated as Dalton's lymphoma (DL). The results of the present investigation show that physical exercise of a tumor-bearing host on a treadmill results in a better retardation of tumor progression along with prolongation of survival time in male compared to female tumor-bearing host. Such gender dimorphism of the therapeutic benefits of physical exercise in tumor-bearing host was found to be associated with a gender-dependent variation in cell survival and induction of apoptosis in tumor cells. Moreover, expression of cell growth regulatory proteins-selectin, Hsp70, p53, CAD, SOCS, and IL-2 receptor-was found to vary in a gender-specific manner following physical exercise. The investigation also indicates the role of cytokines and macrophages in manifestation of gender dimorphism in the response of tumor-bearing mice to physical exercise. Thus, the observations of the present investigation suggest for the first time that the beneficial effects of physical exercise in a tumor-bearing host may be variable depending on the gender of the host.
authors.affiliation: School of Biotechnology, Banaras Hindu University, Varanasi-221 005, UP India.
authors.forename: Vinod Kumar
authors.initials: VK
authors.lastname: Verma
authors.forename: Vivek
authors.initials: V
authors.lastname: Singh
authors.forename: Mahendra Pal
authors.initials: MP
authors.lastname: Singh
authors.forename: Sukh Mahendra
authors.initials: SM
authors.lastname: Singh
mesh_terms: D000818:Animals; D017209:Apoptosis; D001221:Aspartate Carbamoyltransferase / Q000378:metabolism; D015153:Blotting, Western; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / Q000378:metabolism; D049109:Cell Proliferation; D004080:Dihydroorotase / Q000378:metabolism; D004195:Disease Models, Animal; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000378:metabolism; D016399:Lymphoma, T-Cell / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010805:Physical Conditioning, Animal; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D019087:Selectins / Q000378:metabolism; D012737:Sex Factors; D050826:Suppressor of Cytokine Signaling Proteins / Q000378:metabolism; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: C033626:CAD trifunctional enzyme; D018840:HSP70 Heat-Shock Proteins; D015375:Receptors, Interleukin-2; D019087:Selectins; D050826:Suppressor of Cytokine Signaling Proteins; D016159:Tumor Suppressor Protein p53; D001221:Aspartate Carbamoyltransferase; D004080:Dihydroorotase; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)