Occurrence and significance of the nuclear transcription factor Krüppel-like factor 4 (KLF4) in the vessel wall.
Practically all mammalian cells including human can switch, according to micro- or macroenvironmental conditions, from states of cellular quiescence to inflammatory activation and vice versa. Along with recent knowledge, cellular quiescence is not a passive, but a highly active state with broad engagement of the cell synthetic and secretory machinery. Inflammatory activation is a beneficial process in cases of infection; however, if its control fails, it may degrade into autoimmune diseases or cancer growth. Control over cellular quiescence is exerted predominantly by a set of zinc-finger transcription proteins, referred to as Krüppel-like factors (KLFs). This review article offers recent information concerning activities of Krüppel-like factor 4 in the vascular wall.
Kunes
Pavel
P
Department of Cardiac Surgery, Charles University in Prague, Faculty of Medicine and University Hospital Hradec Králové, Czech Republic. kunes.pavel@fnhk.cz
Holubcová
Zdenka
Z
Krejsek
Jan
J
D000818:Animals; D050197:Atherosclerosis / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000293:injuries / Q000502:physiology / Q000503:physiopathology
C096161:KLF2 protein, human; C000715467:KLF4 protein, human; D000090062:Kruppel-Like Factor 4; D051741:Kruppel-Like Transcription Factors