title: [Engineering the enantioselectivity of biocatalysts].
abstract: Wild-type biocatalysts usually show high activity and selectivity towards their native substrates. Since non-native substrates are often used in synthetically useful biocatalytic transformations, it is necessary to engineer enzymes for improved activity, stability and selectivity (chemo-, regio- and stereoselectivity). Herein we give an overview of the recent advances in engineering the enantioselectivity of biocatalysts, with an aim to stimulate further development of this important field in China.
authors.affiliation: Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China. jadezhu@hotmail.com
authors.forename: Dunming
authors.initials: D
authors.lastname: Zhu
authors.forename: Qiaqing
authors.initials: Q
authors.lastname: Wu
mesh_terms: D000818:Animals; D055162:Biocatalysis; D004851:Epoxide Hydrolases / Q000235:genetics / Q000378:metabolism; D004950:Esterases / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008049:Lipase / Q000235:genetics / Q000378:metabolism; D015202:Protein Engineering / Q000379:methods*; D013237:Stereoisomerism
chemical_list: D004950:Esterases; D008049:Lipase; D004851:Epoxide Hydrolases