Dianilides of dipicolinic acid function as synthetic chloride channels.
We report that N(2),N(6)-bis(4-nitrophenyl)pyridine-2,6-dicarboxamide, which is related to known isophthalic acid dianilides, transports Cl(-) ions through phospholipid bilayer membranes and shows clear evidence of channel activity.
Yamnitz
Carl R
CR
Department of Chemistry, Washington University, Saint Louis, MO, USA.
Negin
Saeedeh
S
Carasel
I Alexandru
IA
Winter
Rudolph K
RK
Gokel
George W
GW
D000813:Anilides / Q000737:chemistry*; D018118:Chloride Channels / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010848:Picolinic Acids / Q000737:chemistry*
D000813:Anilides; D018118:Chloride Channels; D010848:Picolinic Acids; C004860:dipicolinic acid