Smart nanofibers with a photoresponsive surface for controlled release.
A novel photocontrolled "ON-OFF" release system for the alpha-cyclodextrin-5-fluorouracial (alpha-CD-5FU) prodrug, based on host-guest interaction on the photoresponsive and cross-linked nanofiber surface, was demonstrated. The nanofibers with a stimuli-responsive surface were electrospun from the block copolymer prepared via controlled radical polymerization, followed by surface modification via "Click Chemistry", and loading of the prodrug via host-guest interaction.
Fu
Guo-Dong
GD
Xu
Li-Qun
LQ
Yao
Fang
F
Li
Guo-Liang
GL
Kang
En-Tang
ET
D003432:Cross-Linking Reagents / Q000494:pharmacology; D003692:Delayed-Action Preparations; D008027:Light; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D056951:Photoelectron Spectroscopy; D013499:Surface Properties / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors; D047391:alpha-Cyclodextrins / Q000494:pharmacology*
D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D047391:alpha-Cyclodextrins; C032613:alpha-cyclodextrin