[Association of fibrinogen B beta-chain gene polymorphism with factors affecting obesity].
OBJECTIVE
To study the association of fibrinogen(Fg) B beta -854G/A, -455G/A, -249C/T, -148C/T, 448G/A and Bcl-1G/A gene polymorphisms with factors affecting obesity, and the fibrinogen function such as plasma fibrinogen concentration and molecular reactivity.


METHODS
One thousand and three hundred ninety-one subjects from Kailuan corporation were enrolled by medical examination and questionnaire survey, and were divided into normal weight, overweight and obese groups based on body mass index (BMI). Blood biochemistry, fibrinogen concentration, fibrin monomer polymerized velocity (FMPV), and FMPV/A(max) were measured. The gene polymorphisms of the six loci were detected by polymerase chain reaction-restriction fragment length polymorphism.


RESULTS
The frequencies of Bcl-1A and its mutated genotype in the overweight group were significantly higher than that in the normal weight group (P< 0.01). In all the three groups, Fg concentration, FMPV, FMPV/A(max) in individuals with B beta -854 mutated genotype were significantly higher than those with wild type genotype (P< 0.01), and in the overweight group, FMPV/A(max) in those with B beta -455 mutated genotype, FMPV in those with B beta -249 mutated genotype, were higher than those with wild type genotype (P< 0.05).


CONCLUSIONS
Individuals with Bcl-1A and its mutated genotype are susceptible to overweight. The B beta -455 and -249 mutated genotypes are accumulative genes for overweight by regulating the Fg function.
Yuan
Xiao-dong
XD
Department of Neurology, the Affiliated Kailuan General Hospital of North China Coal Medical University, Tangshan, Hebei, P.R. China. yxd68@sohu.com
Wang
Shu-juan
SJ
Xu
Ya-ru
YR
Li
Jing
J
Yang
Na
N
Li
Hong-fen
HF
Gao
Jie
J
D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005340:Fibrinogen / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D009765:Obesity / Q000235:genetics* / Q000517:prevention & control; D011110:Polymorphism, Genetic; D012044:Regression Analysis
C115499:BBeta fibrinogen; D005340:Fibrinogen