[Factors contributing to gallstone formation and their interaction].
OBJECTIVE
to study factors contributing to gallstone formation and to elucidate their relationship.


METHODS
The examination of 230 patients with various hepatobiliary abnormalities used dynamic ultrasonic cholecystography, multifractional duodenal intubation, followed by a microscopic study and determination of the physicochemical properties of bile. Enzyme immunoassay was employed to measure the peripheral blood levels of gastrin, insulin, T3, T4, thyroid-stimulating hormone, cortisol, and growth hormone.


RESULTS
All the patients were found to have signs of an early (gallstone pre-formation) stage of cholelithiasis. Decreased emptying of the gallbladder and its hypotonia and altered bile physicochemical properties were ascertained to be poor predictors of possible gallstone formation.


CONCLUSIONS
Correlation analysis has shown the important role of hormonal factors in the formation of lithogenic bile.
Vakhrushev
Ia M
IaM
Khokhlacheva
N A
NA
D000328:Adult; D000368:Aged; D001646:Bile / Q000737:chemistry; D015415:Biomarkers / Q000097:blood*; D002765:Cholecystography / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D005704:Gallbladder / Q000000981:diagnostic imaging / Q000473:pathology; D042882:Gallstones / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007124:Immunoenzyme Techniques; D007328:Insulin / Q000097:blood; D007440:Intubation / Q000379:methods; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013972:Thyrotropin / Q000097:blood; D014463:Ultrasonography; D055815:Young Adult
D015415:Biomarkers; D005755:Gastrins; D007328:Insulin; D013972:Thyrotropin; D006854:Hydrocortisone