title: [Corneal melting in both eyes after simultaneous corneal cross-linking in a patient with keratoconus and Down syndrome].
abstract: Corneal cross-linking is one of the options for treatment of progressive keratoconus. Following the published standards regarding indication and treatment schedules, it seems to be a highly safe and effective operation. Only a very few severe complications, such as stromal scarring and bacterial keratitis, have been reported.We describe a patient with keratoconus and Down syndrome who was treated with corneal cross-linking on both eyes simultaneously. One week after the operation he developed central corneal melting without signs of infection in his right eye, and 1 month after the operation in his left eye. Penetrating keratoplasties had to be performed on both eyes and were successful. A possible reason for the corneal melting might have been a corneal stroma that was thinner than the proposed limit of 400 µm at the centre. The published recommended standards should be met.
authors.affiliation: Universitäts-Augenklinik, Medizinische Universität Graz, Auenbruggerplatz 4, 8036, Graz, Österreich. christoph.faschinger@medunigraz.at
authors.forename: C
authors.initials: C
authors.lastname: Faschinger
authors.forename: R
authors.initials: R
authors.lastname: Kleinert
authors.forename: A
authors.initials: A
authors.lastname: Wedrich
mesh_terms: D003316:Corneal Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D003432:Cross-Linking Reagents / Q000009:adverse effects; D004314:Down Syndrome / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007640:Keratoconus / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects; D012256:Riboflavin / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D003432:Cross-Linking Reagents; D012256:Riboflavin