Visuo-motor and cognitive procedural learning in children with basal ganglia pathology.
We investigated procedural learning in 18 children with basal ganglia (BG) lesions or dysfunctions of various aetiologies, using a visuo-motor learning test, the Serial Reaction Time (SRT) task, and a cognitive learning test, the Probabilistic Classification Learning (PCL) task. We compared patients with early (<1 year old, n=9), later onset (>6 years old, n=7) or progressive disorder (idiopathic dystonia, n=2). All patients showed deficits in both visuo-motor and cognitive domains, except those with idiopathic dystonia, who displayed preserved classification learning skills. Impairments seem to be independent from the age of onset of pathology. As far as we know, this study is the first to investigate motor and cognitive procedural learning in children with BG damage. Procedural impairments were documented whatever the aetiology of the BG damage/dysfunction and time of pathology onset, thus supporting the claim of very early skill learning development and lack of plasticity in case of damage.
Mayor-Dubois
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C
Pediatric Neurology and Neurorehabilitation Unit, University Hospital, Lausanne, Switzerland. Claire.Mayor@chuv.ch
Maeder
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Zesiger
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P
Roulet-Perez
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E
D000293:Adolescent; D001480:Basal Ganglia Diseases / Q000150:complications* / Q000473:pathology*; D001931:Brain Mapping; D002648:Child; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D019359:Knowledge; D007858:Learning / Q000502:physiology*; D008297:Male; D009483:Neuropsychological Tests; D011337:Probability Learning; D011930:Reaction Time / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*