Developing an engineered antimicrobial/prophylactic system using electrically activated bactericidal metals.
The increased use of Residual Hardware Devices (RHDs) in medicine combined with antimicrobial resistant-bacteria make it critical to reduce the number of RHD associated osteomyelitic infections. This paper proposes a surface treatment based on ionic emission to create an antibiotic environment that can significantly reduce RHD associated infections. The Kirby-Bauer agar gel diffusion technique was adopted to examine the antimicrobial efficacy of eight metals and their ionic forms against seven microbes commonly associated with osteomyelitis. Silver ions (Ag(+)) showed the most significant bactericidal efficacy. A second set of experiments, designed to identify the best configuration and operational parameters for Ag(+) based RHDs addressed current and ionic concentrations by identifying and optimizing parameters including amperage, cathode and anode length, separation between anode and cathode, and surface charge density. The system demonstrated an unparalleled efficacy. The concept was then implemented during in vitro testing of an antimicrobial hip implant, RHD.
Fuller
Thomas A
TA
ArgentumCidalElectrics, Incorporated, P.O. Box 254, Lewistown, PA 17044, USA. fuller@argentumce.com
Wysk
Richard A
RA
Charumani
Charumani
C
Kennett
Mary
M
Sebastiennelli
Wayne J
WJ
Abrahams
Rachel
R
Shirwaiker
Rohan A
RA
Voigt
Robert C
RC
Royer
Patricia
P
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D004560:Electricity; D004566:Electrodes; D005782:Gels; D006801:Humans; D008670:Metals / Q000494:pharmacology; D012834:Silver / Q000494:pharmacology; D018030:Silver Compounds / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D005782:Gels; D008670:Metals; D018030:Silver Compounds; D012834:Silver