[Influence of chromone compounds on the activity of selected antioxidant enzymes in patients with physical limitations].
Coxarthrosis used to be referred to as the "doctors' cross" pointing to the difficulties of the treatment. Degenerative processes in the bones usually concern large joints: knee joints in 25-40% of cases, similarly in case of hip joints. Because of the role the joints play, the arthrosis may result in physical limitations or disability. The aim of the study was to evaluate the activity of catalase and superoxide dismutase (CuZn-SOD) in erythrocytes in patients suffering from the coxarthrosis--as the studied group and in healthy people--as the control group.


METHODS
Determining the activity of catalase and superoxide dismutase in the group of 17 patients hospitalized because of coxarthrosis.


RESULTS
In the study about 90% increase of the activity of the enzymes was determined in the studied group, in which the chemical compound 3{(2-aminothiazolyl)methylene}4H-1-benzopyran-4-one was added to the blood, in comparison with the control group.


CONCLUSIONS
The results of the test on catalase and superoxide dismutase clearly indicate that the free radicals participate in the whole course of coxarthrosis.
Malinowska
Katarzyna
K
Uniwersytet Medyczny w Łodzi: Wydzial Fizjoterapii, Zakład Chemii i Biochemii Klinicznej, Katedra Chemii i Biochemii Klinicznej.
Modranka
Roman
R
D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D002374:Catalase / Q000097:blood*; D002867:Chromones / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects* / Q000201:enzymology*; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D015207:Osteoarthritis, Hip / Q000150:complications / Q000201:enzymology*; D020370:Osteoarthritis, Knee / Q000150:complications / Q000201:enzymology*; D018384:Oxidative Stress; D010146:Pain / Q000209:etiology; D013482:Superoxide Dismutase / Q000097:blood*
C550101:3-((2-aminothiazolyl)methylene)4H-1-benzopyran-4-one; D000975:Antioxidants; D002867:Chromones; D005609:Free Radicals; D002374:Catalase; D013482:Superoxide Dismutase