title: Regulation and role of organic anion-transporting polypeptides (OATPs) in drug delivery at the choroid plexus.
abstract: The organic anion-transporting polypeptides (rodents: Oatps; human: OATPs) belong to the growing family of organic anion/prostaglandin transporters and are important components of the active efflux transport system at the choroid plexus epithelial cells. OATPs facilitate the elimination of xenobiotics and endogenous waste from the cerebrospinal fluid and prevent waste accumulation in the central nervous system (CNS). This review summarizes the structures, regulations and roles of Oatps/OATPs at the choroid plexus in drug delivery to the CNS.
authors.affiliation: Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, 44 WenHuaXi Road, Jinan 250012, China.
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Yu-Ning
authors.initials: YN
authors.lastname: Song
authors.forename: Wei-Guo
authors.initials: WG
authors.lastname: Liu
authors.forename: Xiu-Li
authors.initials: XL
authors.lastname: Guo
authors.forename: Lu-Gang
authors.initials: LG
authors.lastname: Yu
mesh_terms: D000818:Animals; D002831:Choroid Plexus / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D027361:Organic Anion Transporters / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D021381:Protein Transport; D014018:Tissue Distribution
chemical_list: D027361:Organic Anion Transporters