The influence of condition on permeation of Ca(II) ions from solutions of selected calcium's salts through model membrane.
The permeation of calcium's ions from calcium solutions of fumarate, gluconate, and citrate through model membrane from the donor chamber to the acceptor chamber has been examined. Process was traced depending on the concentration of the appropriate calcium's salts (1, 2.5, and 5 mmol/l) and pH value of acceptor environment (1.3, 6.2, and 7.4) which imitated natural conditions appearing in the digestive tract. The amount of permeating Ca(II) ions (percent) and their Ca(II) availability AUC (0-6 h) has been determined. In dependence on the conditions, penetration was as follows: 30.3-95.2% of calcium ions from fumarate solution; 73.0-90.1% of Ca(II) from citrate solution; and 19.0-95.0% of Ca from gluconate solution. The investigation indicates that the amount of permeated Ca(II) ions and their availability are connected with the concentration of the calcium salt and pH of acceptor environment. Fumarate and citrate are available at pH value of acceptor environment 1.3 and 6.2 and gluconate at the pH value of 6.2 and 7.4. These substances are practically unavailable from the acceptor environment at pH value 1.3 for gluconate and 7.4 for fumarate. Results suggest that calcium citrate can be available for organism independently from pH value of acceptor environment.
Dolińska
Barbara
B
Biochefa Pharmaceutical Research and Production Plant, Kasztanowa 3, Sosnowiec, Poland. b.dolinska@biochefa.pl
Mikulska
Agnieszka
A
Ostróżka-Cieślik
Aneta
A
Ryszka
Florian
F
D002118:Calcium / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007477:Ions / Q000737:chemistry; D008567:Membranes, Artificial; D008956:Models, Chemical; D012492:Salts / Q000737:chemistry; D012996:Solutions
D007477:Ions; D008567:Membranes, Artificial; D012492:Salts; D012996:Solutions; D002118:Calcium