Contribution of Streptococcus anginosus to infections caused by groups C and G streptococci, southern India.
Vellore, a region in southern India, has a high incidence of severe human infections with Beta-hemolytic group C and G streptococci (GCGS). To determine the causative species in these infections, we conducted 16S rRNA gene sequencing: Streptococcus dysgalactiae subsp. equisimilis (81%) and S. anginosus (19%) were the causative organisms in the 2-year study period (2006-2007). We used PCR to detect the virulence-related emm gene; results showed that it was restricted to S. dysgalactieae subsp. equisimilis isolates of 99.2% tested positive. Due to a novel marker, S. anginosus and S. constellatus can be quickly and accurately distinguished from other members of the genus. The notable contribution of the anginosus group to human infections suggests that this group of obligate pathogens deserves more attention in healthcare and research.
Reissmann
Silvana
S
Helmholtz Centre for Infection Research, Braunschweig, Germany.
Friedrichs
Claudia
C
Rajkumari
Reena
R
Itzek
Andreas
A
Fulde
Marcus
M
Rodloff
Arne C
AC
Brahmadathan
Kootallur N
KN
Chhatwal
Gursharan S
GS
Nitsche-Schmitz
D Patric
DP
D004269:DNA, Bacterial / Q000235:genetics; D005798:Genes, Bacterial / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D007194:India / Q000453:epidemiology; D016366:Open Reading Frames / Q000235:genetics; D016133:Polymerase Chain Reaction; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D017422:Sequence Analysis, DNA; D013290:Streptococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D013291:Streptococcus / Q000235:genetics; D034366:Streptococcus anginosus / Q000235:genetics; D034365:Streptococcus constellatus / Q000235:genetics; D037521:Virulence Factors / Q000235:genetics
D004269:DNA, Bacterial; D005819:Genetic Markers; D012336:RNA, Ribosomal, 16S; D037521:Virulence Factors