Microbial transformation of selected flavanones as a method of increasing the antioxidant properties.
Antioxidant properties of substrates [flavanone (1), 6-hydroxy- (2), 7-hydroxy- (3), 5,7,4'-trihydroxy- (5), and 7-methoxyflavanone (4)] and products of their microbial transformations, comprising hydroxylation, O-methylation, stereospecific reduction, dehydrogenation, and C-ring cleavage of the benzo-gamma-pyrone system, were determined. Measurements of the antiradical activity (expressed as IC50 value) of both the substrates and the products led to the determination of the impact of type and location of substituents in the tested flavonoids on changes in their antioxidant activities.
Kostrzewa-Susłow
Edyta
E
Department of Chemistry, Wrocław University of Environmental and Life Sciences, Norwida 25, 50-375 Wrocław, Poland. edyta.kostrzewa-suslow@up.wroc.pl
Dmochowska-Gładysz
Jadwiga
J
Janeczko
Tomasz
T
D000935:Antifungal Agents / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects; D001711:Biotransformation; D044950:Flavanones / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry; D010407:Penicillium / Q000187:drug effects; D010944:Plants / Q000737:chemistry; D011048:Polarography / Q000379:methods
D000935:Antifungal Agents; D000975:Antioxidants; D044950:Flavanones; D005419:Flavonoids