title: Adenoma of the retinal pigment epithelium: a report of 3 cases.
abstract: OBJECTIVE
  To report the clinical manifestations and pathologic features of adenoma of the retinal pigment epithelium (RPE).
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Three patients with an initial clinical diagnosis of choroidal melanoma.
  
  
  METHODS
  Routine eye examinations, including visual acuity, intraocular pressure, slit-lamp examination, and ophthalmoscopy, were performed. Auxiliary examinations included fluorescein fundus angiography (FFA), indocyanine green angiography (ICGA), B-scan ultrasonography, colour Doppler imaging (CDI), and MRI. Endoresection of the tumours was performed, and the specimens underwent pathological examination.
  
  
  RESULTS
  The tumours were of yellow-pink or brown colour and all located in the right eye. On FFA and ICGA, the tumours demonstrated hypofluorescence in the early phase and hyperfluorescence with prominent leakage in the late phase. CDI showed arterial blood signals in the tumour, and MRI showed hyperintensity in the T1-weighted image and hypointensity in the T2-weighted image. On pathological examination all the tumours were positive with periodic acid-Schiff, S-100, neurone-specific enolase, synaptophysin, epithelial membrane antigen, and vimentin staining but negative with melanoma-specific antigen HMB45, and cytokeratin. After 3 years of follow-up, there was no tumour recurrence and the retinas remained attached.
  
  
  CONCLUSIONS
  RPE-derived adenoma is difficult to diagnose clinically. In most cases, pathological confirmation is needed. Local resection is a favorable alternative treatment for some patients.
authors.affiliation: Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmic and Visual Science Key Laboratory, Beijing, China. trweiwenbin@yahoo.com.cn
authors.forename: Wenbin
authors.initials: W
authors.lastname: Wei
authors.forename: Jing
authors.initials: J
authors.lastname: Mo
authors.forename: Ying
authors.initials: Y
authors.lastname: Jie
authors.forename: Bin
authors.initials: B
authors.lastname: Li
mesh_terms: D000236:Adenoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D004396:Coloring Agents; D003937:Diagnosis, Differential; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D007208:Indocyanine Green; D007429:Intraocular Pressure / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D019572:Retinal Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D055213:Retinal Pigment Epithelium / Q000473:pathology*; D012189:Retrospective Studies; D014792:Visual Acuity / Q000502:physiology
chemical_list: D014408:Biomarkers, Tumor; D004396:Coloring Agents; D007208:Indocyanine Green