title: Design and Synthesis of Potential New Apoptosis Agents: Hybrid Compounds Containing Perillyl Alcohol and New Constrained Retinoids.
abstract: Novel retinoids 1-3 containing perillyl alcohol were synthesized through the addition of perillyl alcohol to the activated carboxylic acids (retinoids) promoted by DCC (N, N'-Dicylohexyl cabodiimide). A set of structurally and functionally diverse perillyl alcohol derivatives of retinoids were obtained in good yields (78-82%). Biological evaluation of these novel hybrid compounds (containing retinoids and perillyl alcohol) is currently underway in our laboratory.
authors.affiliation: Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Bhaskar C
authors.initials: BC
authors.lastname: Das
authors.forename: Sakkarapalayam M
authors.initials: SM
authors.lastname: Mahalingam
authors.forename: Lipsa
authors.initials: L
authors.lastname: Panda
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Phillp
authors.initials: P
authors.lastname: Campbell
authors.forename: Todd
authors.initials: T
authors.lastname: Evans