title: New diterpenoids from Caesalpinia species and their cytotoxic activity.
abstract: Chemical investigation on Caesalpinia crista afforded two new diterpenoids, 6beta-cinnamoyloxy-7beta-acetoxyvouacapen-5alpha-ol and 6beta,7beta-dibenzoyloxyvouacapen-5alpha-ol and on Caesalpiniapulcherrima another new diterpenoid, 12-demethyl neocaesalpin F along with several known constituents. The structures of the new compounds were settled from their 1D and 2D NMR spectral data. The cytotoxicity of these compounds was measured on two different cancer cell lines.
authors.affiliation: Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India. biswanathdas@yahoo.com
authors.forename: Biswanath
authors.initials: B
authors.lastname: Das
authors.forename: Yallamalla
authors.initials: Y
authors.lastname: Srinivas
authors.forename: Chithaluri
authors.initials: C
authors.lastname: Sudhakar
authors.forename: Ibram
authors.initials: I
authors.lastname: Mahender
authors.forename: Keetha
authors.initials: K
authors.lastname: Laxminarayana
authors.forename: Parigi Raghavendar
authors.initials: PR
authors.lastname: Reddy
authors.forename: Tuniki Venugopal
authors.initials: TV
authors.lastname: Raju
authors.forename: Naga Mahesh
authors.initials: NM
authors.lastname: Jakka
authors.forename: Janapala Venkateswara
authors.initials: JV
authors.lastname: Rao
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D029911:Caesalpinia / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation
chemical_list: C551003:12-demethyl neocaesalpin F; C551002:6,7-dibenzoyloxyvouacapen-5-ol; C551001:6-cinnamoyloxy-7-acetoxyvouacapen-5-ol; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes