title: Estimating input parameters from intracellular recordings in the Feller neuronal model.
abstract: We study the estimation of the input parameters in a Feller neuronal model from a trajectory of the membrane potential sampled at discrete times. These input parameters are identified with the drift and the infinitesimal variance of the underlying stochastic diffusion process with multiplicative noise. The state space of the process is restricted from below by an inaccessible boundary. Further, the model is characterized by the presence of an absorbing threshold, the first hitting of which determines the length of each trajectory and which constrains the state space from above. We compare, both in the presence and in the absence of the absorbing threshold, the efficiency of different known estimators. In addition, we propose an estimator for the drift term, which is proved to be more efficient than the others, at least in the explored range of the parameters. The presence of the threshold makes the estimates of the drift term biased, and two methods to correct it are proposed.
authors.affiliation: Department of Mathematics G Peano, University of Torino, Via Carlo Alberto 10, 10123 Torino, Italy. enrico.bibbona@unito.it
authors.forename: Enrico
authors.initials: E
authors.lastname: Bibbona
authors.forename: Petr
authors.initials: P
authors.lastname: Lansky
authors.forename: Roberta
authors.initials: R
authors.lastname: Sirovich
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D003198:Computer Simulation; D008564:Membrane Potentials / Q000502:physiology*; D008959:Models, Neurological; D015233:Models, Statistical; D009474:Neurons / Q000502:physiology*