Pneumonia in a patient with familial Mediterranean fever successfully treated with anakinra--case report and review.
We report the case of a 35-years-old renal transplant patient known to have familial Mediterranean fever with serum amyloid A (SAA)-amyloidosis, who presented with his second episode of bilateral pneumonia. As antimicrobials failed to control the first episode of pneumonia and all studies done were non-contributory, we attributed the condition to the highly active Mediterranean fever presumably resistant to colchicine and treated the patient with the interleukin-1 receptor antagonist anakinra: the patient substantially improved by clinical symptoms, chemistry and radiological evidence within no more than 2 days and was discharged in good health after 4 days.
Hennig
Stefanie
S
Department of Internal Medicine I, Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, Waehringerguertel 18-20, 1090, Vienna, Austria.
Bayegan
Keywan
K
Uffmann
Martin
M
Thalhammer
Florian
F
Winkler
Stefan
S
D000328:Adult; D000686:Amyloidosis / Q000209:etiology; D000890:Anti-Infective Agents / Q000627:therapeutic use; D003078:Colchicine / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004351:Drug Resistance; D010505:Familial Mediterranean Fever / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage*; D053590:Interleukin 1 Receptor Antagonist Protein / Q000008:administration & dosage*; D016030:Kidney Transplantation; D008297:Male; D011014:Pneumonia / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D011859:Radiography; D012008:Recurrence; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D007155:Immunologic Factors; D053590:Interleukin 1 Receptor Antagonist Protein; D003078:Colchicine