title: Preparation and characterization of lectin-conjugated chitosan fluorescent nanoparticles.
abstract: The purpose of this study was to design and evaluate a novel target nanoparticle for disease detection and drug delivery using the biotin-avidin binding system. The formed lectin-conjugated chitosan fluorescent nanoparticles were of spherical shape(100-200 nm in diameter), which were more stable under light than pure fluorescein isothiocyanate (FITC).
authors.affiliation: Nanomedicine Laboratory, Center for Regenerative Medicine, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.
authors.forename: Jingping
authors.initials: J
authors.lastname: Liu
authors.forename: Lanlan
authors.initials: L
authors.lastname: Zhang
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
authors.forename: Hongyan
authors.initials: H
authors.lastname: Xu
authors.forename: Xiaojun
authors.initials: X
authors.lastname: Zhao
mesh_terms: D001710:Biotin / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D004339:Drug Compounding; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D037102:Lectins / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D008856:Microscopy, Fluorescence; D008956:Models, Chemical; D053758:Nanoparticles / Q000737:chemistry*; D010835:Phytohemagglutinins / Q000737:chemistry; D013053:Spectrophotometry
chemical_list: D004337:Drug Carriers; D005456:Fluorescent Dyes; D037102:Lectins; D010835:Phytohemagglutinins; D001710:Biotin; D048271:Chitosan; D016650:Fluorescein-5-isothiocyanate