title: Antitumor activity of methylan polysaccharide derivatives.
abstract: Methylan polysaccharide derivatives were prepared by dialkylaminoalkylation and reductive amination followed by quaternization. Their antitumor activity was investigated and a relationship between structure and activity is suggested. For quaternized DEAE-methylan at only 75 mug ml(-1), tumor cell proliferation was suppressed by 58-84% in three cell lines tested in the order Colo < Hela < HepG2.
authors.affiliation: Department of Chemical Enginering, Konkuk University, Hwayang-Dong, Kwangjin-Ku, Seoul, 143-701, Korea.
authors.forename: Priyadharshini
authors.initials: P
authors.lastname: Ramachandran
authors.forename: Marimuthu
authors.initials: M
authors.lastname: Jeya
authors.forename: Hee-Jung
authors.initials: HJ
authors.lastname: Moon
authors.forename: Kyoung-Mi
authors.initials: KM
authors.lastname: Lee
authors.forename: In-Won
authors.initials: IW
authors.lastname: Kim
authors.forename: Jung-Hoe
authors.initials: JH
authors.lastname: Kim
authors.forename: Jung-Kul
authors.initials: JK
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D011134:Polysaccharides