title: Effect of obesity on platelet reactivity and response to low-dose aspirin.
abstract: Insufficient platelet function suppression by aspirin is a predictor of cardiovascular events in high-risk patients. The authors assessed the impact of obesity on platelet responsiveness before and after 2 weeks of aspirin 81 mg/d in 2014 people. Obese individuals had greater baseline platelet reactivity. Comparing obese and nonobese individuals after aspirin therapy, results for aggregometry to collagen were 6.7 vs 6.1 ohms, P=.008; aggregometry to adenosine diphosphate were 13.1 vs 11.8 ohms,P<.0001; aggregometry to arachidonic acid (AA) were 4.9% vs 8.3% nonzero aggregation, P=.002; urinary excretion of 11-dehydro-thromboxane B2 (Tx-M) were 4.9% vs 8.3% nonzero aggregation, P=.002; and aspirin resistance were 26.% vs 20.5%, P=.002; respectively. These remained significantly different for AA aggregation and Tx-M excretion after adjustment for covariates. Obese individuals have greater native platelet reactivity and retain greater reactivity after suppression by aspirin.
authors.affiliation: Department of Population Medicine, Harvard Medical School, Boston, MA, USA.
authors.forename: Bryan C
authors.initials: BC
authors.lastname: Bordeaux
authors.forename: Rehan
authors.initials: R
authors.lastname: Qayyum
authors.forename: Lisa R
authors.initials: LR
authors.lastname: Yanek
authors.forename: Dhananjay
authors.initials: D
authors.lastname: Vaidya
authors.forename: Lewis C
authors.initials: LC
authors.lastname: Becker
authors.forename: Nauder
authors.initials: N
authors.lastname: Faraday
authors.forename: Diane M
authors.initials: DM
authors.lastname: Becker
mesh_terms: D000328:Adult; D016718:Arachidonic Acid; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects*; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D016022:Case-Control Studies; D003094:Collagen; D004351:Drug Resistance; D005260:Female; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood* / Q000150:complications; D010641:Phenotype; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D010979:Platelet Function Tests; D013997:Time Factors
chemical_list: D010975:Platelet Aggregation Inhibitors; D016718:Arachidonic Acid; D003094:Collagen; D001241:Aspirin