title: Heat shock memory in preimplantation mouse embryos.
abstract: To investigate the consequences of possible physiologic stress to embryos caused by in vitro fertilization procedures, we used heat shock response in preimplantation mouse embryos as a model. A heat shock "memory" was discovered that renders cleavage-stage embryos more responsive at the transcriptional level to secondary perturbation with very low doses of heat, even several cell cycles after the initial stress has occurred.
authors.affiliation: Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA.
authors.forename: Yanwei
authors.initials: Y
authors.lastname: Jia
authors.forename: Cristina
authors.initials: C
authors.lastname: Hartshorn
authors.forename: Odelya
authors.initials: O
authors.lastname: Hartung
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Wangh
mesh_terms: D000818:Animals; D001755:Blastocyst / Q000502:physiology*; D005307:Fertilization in Vitro; D018869:Heat-Shock Response / Q000235:genetics*; D051379:Mice