title: The level of vascular endothelial cell growth factor, nitric oxide, and endothelin-1 was correlated with ovarian volume or antral follicle counts: a potential predictor of pregnancy outcome in IVF.
abstract: The objective of this study was to investigate the correlation between the concentrations of vascular endothelial cell growth factor (VEGF), nitric oxide (NO), or endothelin-1 (ET-1) in follicular fluid with antral follicle counts (AFCs) or ovarian volume in order to predict the outcome of in vitro fertilization (IVF). One hundred and thirty-one patients were enrolled in this study, and the pregnancy rate was 37.4%. The concentration of VEGF or NO was significantly increased, while the concentration of ET-1 in follicular fluid was decreased in the group who became pregnant (P&#x00A0;&lt;&#x00A0;0.05). The ovarian volume or AFC was significantly higher in groups that became pregnant (P&#x00A0;&lt;&#x00A0;0.05). In addition, the ovarian volume or AFC was positively correlated with the concentration of VEGF or NO and negatively correlated with the concentration of ET-1 in follicular fluid. Our data suggest that these correlations may be associated with the successful pregnancies through IVF.
authors.affiliation: Wuxi Maternity and Child Health Hospital, Nanjing Medical University, Nanjing, PR China.
authors.forename: M
authors.initials: M
authors.lastname: Zhao
authors.forename: C
authors.initials: C
authors.lastname: Chang
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: L M
authors.initials: LM
authors.lastname: Chen
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
mesh_terms: D000328:Adult; D002452:Cell Count; D019332:Endothelin-1 / Q000032:analysis*; D005260:Female; D005307:Fertilization in Vitro; D015571:Follicular Fluid / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D009569:Nitric Oxide / Q000032:analysis*; D009929:Organ Size; D006080:Ovarian Follicle / Q000737:chemistry / Q000166:cytology* / Q000254:growth & development*; D011247:Pregnancy; D018873:Pregnancy Rate; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis*
chemical_list: D019332:Endothelin-1; D042461:Vascular Endothelial Growth Factor A; D009569:Nitric Oxide