Activation of the human contact system on neutrophil extracellular traps.
Pattern recognition is an integral part of the innate immune system. The human contact system has been shown to interact with the surface of many bacterial and fungal pathogens, and once activated leads to the generation of antimicrobial peptides and the proinflammatory mediator bradykinin. Here we show that apart from these surfaces also neutrophil extracellular traps (NETs) provide a surface that allows the binding and activation of the contact system. In addition, we present evidence that M1 protein, a streptococcal surface protein, in concert with human fibrinogen triggers polymorphonuclear neutrophils to form NETs.
Oehmcke
Sonja
S
Department of Clinical Sciences, Division of Infection Medicine, Lund University, Lund, Sweden. Sonja.Oehmcke@med.lu.se
Mörgelin
Matthias
M
Herwald
Heiko
H
D000942:Antigens, Bacterial / Q000276:immunology / Q000378:metabolism; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology / Q000378:metabolism; D002352:Carrier Proteins / Q000276:immunology / Q000378:metabolism; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D005110:Extracellular Space / Q000235:genetics / Q000378:metabolism*; D005340:Fibrinogen / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D007162:Immunoproteins / Q000378:metabolism*; D007704:Kininogens / Q000378:metabolism*; D018375:Neutrophil Activation / Q000276:immunology; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism / Q000648:ultrastructure*; D057057:Serine Proteases / Q000378:metabolism*; D013297:Streptococcus pyogenes / Q000276:immunology / Q000472:pathogenicity
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins; D007162:Immunoproteins; D007704:Kininogens; C014689:streptococcal M protein; D005340:Fibrinogen; D004247:DNA; D057057:Serine Proteases