title: Cellular Senescence is a Common Characteristic Shared by Preneoplasic and Osteo-Arthritic Tissue.
abstract: OBJECTIVE
  This study aims at highlighting the common signature between cartilaginous tissue in osteoarthritis (OA) and preneoplasic tissues preceding neoplasia and tumour formation and, second, focusing on the molecular mechanisms at the aetiology of both pathologies.
  
  
  RESULTS
  Because age is the highest risk factor common for both OA and cancer development, it is tempting to compare the molecular mechanisms occurring at the onset of OA and preneoplasic lesions. Indeed, cellular senescence seems to be a common characteristic. Cellular senescence represents a natural barrier to suppress the unscheduled proliferation of damaged cells acting as a strong tumour suppressor pathway and in OA, it also occurs prematurely in chondrocytes. In this study, we review a number of molecular factors associated with the senescent phenotype.
  
  
  CONCLUSIONS
  Whereas accumulation of senescent cells in preneoplasic-like lesions leads to tissue degeneration and potentially tumour development; in OA, senescent cells accumulate in a slowly proliferative tissue. This is likely contributing at reducing the risk of cell transformation.
authors.affiliation: Inserm, U844, Montpellier, F-34295, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Brondello
authors.forename: Didier
authors.initials: D
authors.lastname: Philipot
authors.forename: Farida
authors.initials: F
authors.lastname: Djouad
authors.forename: Christian
authors.initials: C
authors.lastname: Jorgensen
authors.forename: Danièle
authors.initials: D
authors.lastname: Noël