title: Local intra-arterial administration of urokinase in the treatment of a feline distal aortic thromboembolism.
abstract: A 5-year old neutered male cat was admitted to our hospital in the early morning with sudden onset of bilateral hindlimbs paralysis. Conservative anticoagulant therapy using heparin, warfarin, and dipyridamole, and thrombolytic therapy with urokinase administered by intravenous infusion were started. However, no improvement was noted even after 2 days of treatment, and the cat was started on local intra-arterial administration of urokinase via a catheter on disease day 3. Successful thrombolysis could be accomplished by this approach, and the motor function of both hindlimbs recovered on disease day 5. The cat could be discharged on disease day 9. Complications such as hemorrhage and hyperkalemia were not observed during the thrombolytic therapy. These results suggest that local intra-arterial administration of urokinase may be an effective approach for the treatment of FATE.
authors.affiliation: Division of Veterinary Internal Medicine, Department of Veterinary Science, Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Musashino-shi, Tokyo, Japan. hkoyama@nvlu.ac.jp
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Koyama
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Ryu-uji
authors.initials: RU
authors.lastname: Fukushima
authors.forename: Hisashi
authors.initials: H
authors.lastname: Hirose
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging; D001783:Blood Flow Velocity; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D007261:Infusions, Intra-Arterial / Q000379:methods / Q000662:veterinary; D008297:Male; D009919:Orchiectomy / Q000662:veterinary; D013902:Radiography, Thoracic / Q000379:methods / Q000662:veterinary; D013923:Thromboembolism / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000925:Anticoagulants; D014568:Urokinase-Type Plasminogen Activator