Adenosine and 2'-deoxyadenosine modified with boron cluster pharmacophores as new classes of human blood platelet function modulators.
Novel types of adenosine and 2'-deoxyadenosine derivatives containing boron clusters at positions C2', N6, or C8 were synthesized. The effect of these modified compounds on platelet function was studied. Modification of adenosine at the C2' position with a para-carborane cluster (C(2)B(10)H(11)) results in efficient inhibition of platelet function, including aggregation, protein secretion, and P-selectin expression induced by thrombin or ADP. These preliminary findings and the new chemistry proposed form the basis for the development of a new class of adenosine analogues that modulate human blood platelet activities.
Bednarska
Katarzyna
K
Institute for Medical Biology, Polish Academy of Sciences, Łódź, Poland.
Olejniczak
Agnieszka B
AB
Wojtczak
Błazej A
BA
Sułowska
Zofia
Z
Leśnikowski
Zbigniew J
ZJ
D000241:Adenosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects*; D001895:Boron / Q000737:chemistry*; D003839:Deoxyadenosines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D005343:Fibrinolytic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D019007:P-Selectin / Q000378:metabolism; D010974:Platelet Aggregation; D010979:Platelet Function Tests; D013917:Thrombin / Q000378:metabolism
D003839:Deoxyadenosines; D005343:Fibrinolytic Agents; D019007:P-Selectin; D013917:Thrombin; D000241:Adenosine; D001895:Boron; C058118:2'-deoxyadenosine