Simplifying pyridoxal: practical methods for amino acid dynamic kinetic resolution.
Metal complexes of picolinaldehyde are identified as low-cost and environmentally benign catalysts, providing high reaction rates and turnovers for the racemization of amino acids. These pyridoxal surrogates demonstrate activity toward a variety of amino acid esters. Applications to chemoenzymatic dynamic kinetic resolutions provide access to amino acids in high yields and with excellent enantioselectivities, demonstrating their compatibility with protease-mediated transformations.
Felten
Albert E
AE
Department of Chemistry, Indiana University, 800 East Kirkwood Avenue, Bloomington, Indiana 47405-7102, USA.
Zhu
Gangguo
G
Aron
Zachary D
ZD
D000596:Amino Acids / Q000737:chemistry*; D007700:Kinetics; D011730:Pyridoxal / Q000737:chemistry*
D000596:Amino Acids; D011730:Pyridoxal