title: Our experiences with the use of atopy patch test in the diagnosis of cow's milk hypersensitivity.
abstract: Atopy patch test has been recognized as a diagnostic tool for the verification of food allergies in infants and small children suffering from atopic dermatitis. The test also has a role in the diagnosis of food allergies characterized by clinical signs associated with the digestive system. Yet, in spite of numerous studies, the test itself has hitherto not been standardized. Our study enlisted 151 children less than two years of age, who exhibited suspect skin and/or gastrointestinal manifestations of food allergy to cow's milk, and in whom tests failed to prove early type of allergic reaction. Atopy patch test was positive in 28% of the children with atopic dermatitis, 43% of the children with suspect gastrointestinal manifestation and 32% of the children with skin and gastrointestinal manifestations of food allergy. In our experience, atopy patch test is an excellent addition to the hitherto used tests for the diagnosis of food allergies. It targets specifically delayed type hypersensitivity reactions, which are difficult to confirm with other diagnostic tools. It is furthermore simple to perform, noninvasive and produces a minimum of undesired side effects. For these reasons, it should become part of the routine diagnostic toolset for food allergies to cow's milk in infants and children, and applied before a food challenge test.
authors.affiliation: Department of Reproductive Health, Zagreb Children's Hospital, Klaićeva 16, HR-10000 Zagreb, Croatia. nives.pustisek@kdb.hr
authors.forename: Nives
authors.initials: N
authors.lastname: Pustisek
authors.forename: Alemka
authors.initials: A
authors.lastname: Jaklin-Kekez
authors.forename: Ruza
authors.initials: R
authors.lastname: Frkanec
authors.forename: Nives
authors.initials: N
authors.lastname: Sikanić-Dugić
authors.forename: Zrinjka
authors.initials: Z
authors.lastname: Misak
authors.forename: Oleg
authors.initials: O
authors.lastname: Jadresin
authors.forename: Sanja
authors.initials: S
authors.lastname: Kolacek
mesh_terms: D000818:Animals; D002417:Cattle; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D016269:Milk Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D010328:Patch Tests