Design and Synthesis of Potential New Apoptosis Agents: Hybrid Compounds Containing Perillyl Alcohol and New Constrained Retinoids.
Novel retinoids 1-3 containing perillyl alcohol were synthesized through the addition of perillyl alcohol to the activated carboxylic acids (retinoids) promoted by DCC (N, N'-Dicylohexyl cabodiimide). A set of structurally and functionally diverse perillyl alcohol derivatives of retinoids were obtained in good yields (78-82%). Biological evaluation of these novel hybrid compounds (containing retinoids and perillyl alcohol) is currently underway in our laboratory.
Das
Bhaskar C
BC
Department of Nuclear Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
Mahalingam
Sakkarapalayam M
SM
Panda
Lipsa
L
Wang
Bo
B
Campbell
Phillp
P
Evans
Todd
T