title: [Analysis of imaging and clinical feature of leukoencephalopathy with hearing loss first complaint].
abstract: OBJECTIVE
  To investigate the imaging and clinical feature of leukoencephalopathy with hearing loss first complaint.
  
  
  METHODS
  The head MRI and clinical feature of 7 cases leukoencephalopathy with hearing loss first complaint were retrospectively analysed, including their place, shape, range and blood plasma very-long-chain fatty acid (VLCFA).
  
  
  RESULTS
  The head MRI of 2 cases shows symmetry distributed long T, and T2 signal like butterfly aliform in white matter beside both cornu posterior ventriculi lateralis. The head MRI of 5 cases shows abnormal long T1 and T2 signal in different part in Alba. The pathological changes often located in white matter of frontal lobe and secondly beside both cornu posterior ventriculi lateralis. The shape shows little patching in 7 cases. The range only shows beside cornu posterior ventriculi lateralis in 2 cases. The range only shows in frontal lobe in 1 cases. Two or more than two parts shows in the rest 5 cases. The result of VLCFA is normal in 3 cases. The rest 4 cases refused to have examination of VLCFA.
  
  
  CONCLUSIONS
  The patient who firstly complained of hearing loss should be routinely done head MRI. The head MRI imaging could clearly show abnormal white matter in order to avoid omitting existent pathological changes.
authors.affiliation: Department of Otorhinolaryngology, Beijing Friendship Hospital, Capital University of Medical Science, Beijing, 100050, China.
authors.forename: Lin'e
authors.initials: L
authors.lastname: Wang
authors.forename: Daoxing
authors.initials: D
authors.lastname: Zhang
authors.forename: Qingxue
authors.initials: Q
authors.lastname: Ma
authors.forename: Qiming
authors.initials: Q
authors.lastname: Xue
authors.forename: Yanchen
authors.initials: Y
authors.lastname: Xie
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D034381:Hearing Loss / Q000175:diagnosis* / Q000209:etiology; D006801:Humans; D056784:Leukoencephalopathies / Q000150:complications / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D008297:Male; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed