title: [Role of chromosomal rearrangement and conservative chromosome sites in amniote evolution].
abstract: Specific features of evolution of chromosomes in mammals and other amniotes are reviewed. Comparative analysis of chromosome architecture revealed nonrandom distribution of chromosome rearrangement sites in genome, probable role of chromosome rearrangement in adaptation, and evolution-mediated selection of conservative chromosome sites. The chromosome sites stable during evolution are saturated with genes contributing to early organism development. Ruptures of these sites are incompatible with organism survival. Further analysis of chromosome evolution requires more information about completely sequenced genomes.
authors.forename: D M
authors.initials: DM
authors.lastname: Larkin
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics; D000818:Animals; D033481:Chromosomes, Mammalian / Q000235:genetics*; D019143:Evolution, Molecular; D006801:Humans; D051379:Mice; D011995:Recombination, Genetic