title: Tumour perfusion assessment during regional hyperthermia treatment: comparison of temperature probe measurement with H(2)(15)O-PET perfusion.
abstract: OBJECTIVE
  Hyperthermia treatment might increase tumour oxygenation and perfusion, as has been reported for experimental tumours. The present study was performed to investigate this hypothesis in patients undergoing regional hyperthermia treatment.
  
  
  METHODS
  Thirteen patients with primary or recurrent pelvic tumours were included in this study. Prior to and up to one hour after regional hyperthermia, perfusion was quantitatively determined by H(2)(15)O-PET. The fused CT-PET images were used to extract tumour time-activity curves and to identify the catheter position. Perfusion was calculated from the total tumour time-activity curves and for the time-activity curves at the catheter site. Additionally, perfusion was calculated from the temperature-time curves measured using temperature probes.
  
  
  RESULTS
  Perfusion values calculated using H(2)(15)O-PET and those deduced from temperature probe measurements are significantly correlated with a correlation coefficient, R = 0.21. The perfusion values deduced from the temperature measured in a body cavity do not provide information about average tumour perfusion. Perfusion values deduced from the temperature are overestimated for very poorly perfused tissues and underestimated for highly perfused tissues.
  
  
  CONCLUSIONS
  Temperature measurement during hyperthermia may allow only determination of intermediate perfusion values.
authors.affiliation: Department of Radiation Therapy, CVK, Charité, Universititätsmedizin Berlin, 13353 Berlin, Germany.
authors.forename: Chi-Hee
authors.initials: CH
authors.lastname: Cho
authors.forename: Geetha
authors.initials: G
authors.lastname: Sreenivasa
authors.forename: Michail
authors.initials: M
authors.lastname: Plotkin
authors.forename: Hubertus
authors.initials: H
authors.lastname: Pietsch
authors.forename: Peter
authors.initials: P
authors.lastname: Wust
authors.forename: Lutz
authors.initials: L
authors.lastname: Lüdemann
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000528:radiation effects; D001831:Body Temperature / Q000528:radiation effects; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D010104:Oxygen Radioisotopes / Q000737:chemistry; D010386:Pelvic Neoplasms / Q000098:blood supply* / Q000628:therapy*; D049268:Positron-Emission Tomography / Q000379:methods*; D000078702:Radiofrequency Therapy; D012004:Rectal Neoplasms / Q000098:blood supply / Q000628:therapy; D012039:Regional Blood Flow / Q000528:radiation effects*; D014057:Tomography, X-Ray Computed / Q000379:methods; D002583:Uterine Cervical Neoplasms / Q000098:blood supply / Q000628:therapy; D014867:Water / Q000737:chemistry
chemical_list: D010104:Oxygen Radioisotopes; D014867:Water