title: TWEAK as a target for therapy in systemic lupus erythematosus.
abstract: Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a recently identified proinflammatory cytokine of the TNF superfamily. Through activation of the fibroblast growth factor-inducible 14 (Fn14) receptor, TWEAK regulates cell proliferation, cell death and inflammation. The available evidences have indicated that TWEAK might be a target for therapeutic intervention in renal, vascular injury and neuropathy. Since renal, vascular and neuropsychiatric complications are frequently encountered in systemic lupus erythematosus (SLE)--a systemic autoimmune disease, TWEAK-Fn14 pathway may be implicated in the pathogenesis of SLE. In this review, we will discuss the TWEAK-Fn14 pathway and the therapeutic potential of modulating this pathway in SLE.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, 230032, Hefei, Anhui, People's Republic of China.
authors.forename: Rui-Xue
authors.initials: RX
authors.lastname: Leng
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.forename: Wei-Zi
authors.initials: WZ
authors.lastname: Qin
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Chen
authors.forename: Jin-Hui
authors.initials: JH
authors.lastname: Tao
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Ye
mesh_terms: D000074049:Cytokine TWEAK; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D000074050:TWEAK Receptor; D048069:Tumor Necrosis Factors / Q000378:metabolism*
chemical_list: D000074049:Cytokine TWEAK; D018124:Receptors, Tumor Necrosis Factor; C000613297:TNFRSF12A protein, human; C109743:TNFSF12 protein, human; D000074050:TWEAK Receptor; D048069:Tumor Necrosis Factors