Vasopressin release induced by hypothension is blunted in patients with diabetic autonomic neuropathy.
The response of arginin-vasopressin (AVP) to baroreceptor activation (tilt testing) was investigated in patients with diabetic autonomic neuropathy (DAN). The present data show that hypothension induced by upright position showed a slight increase of AVP in patients with DAN in comparison with normal subjects and diabetic patients without DAN. These findings suggest that the blunted AVP response to hypothension may be due to lesions of afferent autonomic pathways present in DAN and plays a role in the pathogenesis of postural hypothension.
Iovino
M
M
Department of Endocrinology, General Hospital of Eboli, ASL SA, Piazza Scuola Medica Salernitana, Eboli, Italy.
Triggiani
V
V
Licchelli
B
B
Tafaro
E
E
Giagulli
V
V
Sabbà
C
C
Resta
F
F
Sciannimanico
S V
SV
Panza
R
R
Guastamacchia
E
E
D000344:Afferent Pathways / Q000503:physiopathology; D000368:Aged; D017776:Autonomic Pathways / Q000503:physiopathology; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007024:Hypotension, Orthostatic / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012462:Saline Solution, Hypertonic; D018667:Tilt-Table Test; D014667:Vasopressins / Q000097:blood*
D012462:Saline Solution, Hypertonic; D014667:Vasopressins