title: Low number of peripheral blood B lymphocytes in patients with pulmonary tuberculosis.
abstract: The cellular immune response plays a critical role in the containment of persistent Mycobacterium tuberculosis infection; however, the immunological mechanisms that lead to its control are not completely identified. The goal of this study was to evaluate B (CD19+) and T (CD3+) peripheral blood lymphocyte profiles and T-cell subsets (CD4+ and CD8+) in patients with pulmonary tuberculosis (TB). Percentages (p = 0.02) and absolute numbers (p = 0.005) of B cells were significantly lower in patients with pulmonary TB than in healthy donors. In contrast, percentages (p = 0.12) and absolute numbers (p = 0.14) of T cells were similar in TB patients and healthy donors. No significant differences in percentages of CD4+ (p = 0.19) or CD8+ (p = 0.85) T cells between patients and healthy donors were observed. In summary, patients with pulmonary tuberculosis had a lower number of peripheral blood B lymphocytes than healthy controls.
authors.affiliation: Laboratorio de Inmunología, Centro de Investigación en Alimentación y Desarrollo, A.C., Hermosillo, Sonora, Mexico.
authors.forename: Jesús
authors.initials: J
authors.lastname: Hernandez
authors.forename: Carlos
authors.initials: C
authors.lastname: Velazquez
authors.forename: Olivia
authors.initials: O
authors.lastname: Valenzuela
authors.forename: Ramón
authors.initials: R
authors.lastname: Robles-Zepeda
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ruiz-Bustos
authors.forename: Moisés
authors.initials: M
authors.lastname: Navarro
authors.forename: Adriana
authors.initials: A
authors.lastname: Garibay-Escobar
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D002452:Cell Count; D002469:Cell Separation; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology* / Q000472:pathogenicity; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology
chemical_list: D015703:Antigens, CD