Intestine transplantation in children: update 2010.
This article reviews the current status of pediatric intestinal transplantation, focusing on referral and listing criteria, surgical techniques, patient management, monitoring, complications after transplant, and short- and long-term patient outcome. Intestine transplantation has become the standard of care for children who develop life-threatening complications associated with intestinal failure. The results of intestinal failure treatment have significantly improved in the last decade following the establishment of gut rehabilitation programs and advances in transplant immunosuppressive protocols, surgical techniques, and posttransplant monitoring. The 1-year patient survival is now 80% and more than 80% of the children who survive the transplant are weaned off parenteral nutrition. Early referral for pretransplant assessment and careful follow-up after transplant with prompt recognition and treatment of transplant-related complications are key factors contributing to superior patient outcomes and survival. The best results are being obtained at high-volume centers with survival rates of up to 75% at 5 years.
Avitzur
Yaron
Y
Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children, Toronto, ON M5G 1X8, Canada. yaron.avitzur@sickkids.ca
Grant
David
D
D002648:Child; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D007422:Intestines / Q000637:transplantation*; D016377:Organ Transplantation / Q000009:adverse effects / Q000379:methods / Q000534:rehabilitation; D018579:Patient Selection; D011183:Postoperative Complications; D016896:Treatment Outcome