Comparison of serum apolipoprotein A-I between Chinese multiple sclerosis and other related autoimmune disease.
BACKGROUND
Serum apolipoprotein (apo) A-I was considered to be an immune regulator and could suppress pro-inflammatory cytokines generated by activated T cell in some autoimmune diseases. However, the change of serum apoA-I levels in multiple sclerosis (MS) patients is unknown.


METHODS
In the presentation we performed a study on serum apoA-I levels in the patients with MS. We enrolled some age and gender matched patients with MS, autoimmune demyelinating diseases (Guillain-Barre Syndrome and Clinically Isolated Syndrome), neuroinflammatory diseases (viral encephalitis), autoimmune connective diseases (rheumatoid arthritis and systemic lupus erythematosus) and healthy control groups, and tested their serum lipids levels: total cholesterol (TC), triglyceride (TG), high-density lipoproteins (HDL), apolipoproteinB100 (apoB100), apolipoproteinA-I (apoA-I).


RESULTS
For all patients, age had no effect on serum apoA-I levels (P > 0.05). Meanwhile, we proved the highest serum apoA-I levels in MS patients and the lowest serum apoA-I levels in SLE patients. Serum apoA-I levels was significantly elevated in female MS patients (P = 0.033; P < 0.05).


CONCLUSIONS
In short we believed that patients with MS and other autoimmune demyelination had significantly decreased serum levels of apo A-I.
Zhang
Bin
B
Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and The Ministry of Education of China, The Second Affiliated Hospital of GuangZhou Medical University, 250# Changgang east Road, GuangZhou, 510260 Guangdong Province, China.
Pu
ShuXiang
S
Li
BinMei
B
Ying
JianRui
J
Song
Xing Wang
XW
Gao
Cong
C
D000328:Adult; D000367:Age Factors; D016632:Apolipoprotein A-I / Q000097:blood*; D044466:Asian People; D001327:Autoimmune Diseases / Q000097:blood*; D016022:Case-Control Studies; D003711:Demyelinating Diseases; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood*; D012189:Retrospective Studies; D012737:Sex Factors; D055815:Young Adult
D016632:Apolipoprotein A-I; D008055:Lipids; D008074:Lipoproteins