title: RGS proteins the early days.
abstract: This chapter describes events that transpired in the mid-1990s during the pioneering days of RGS protein research. This period began with early studies of Sst2 in yeast, EGL-10 in nematodes, and the discovery of an expansive family of similar proteins in animals. Within a period of only 2 years, the RGS gene family was first identified, functionally characterized in diverse organisms, and their mechanism of action firmly established. Long considered a three-component signaling system (comprised of a receptor, G protein, and effector enzyme), the discovery of RGS proteins revealed a critical new component of the signaling apparatus, and resolved a long-recognized discrepancy in the rates of G protein inactivation measured in vitro and in vivo.
authors.affiliation: Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599‐7260, USA.
authors.forename: Henrik G
authors.initials: HG
authors.lastname: Dohlman
mesh_terms: D000818:Animals; D049673:History, 20th Century; D020710:RGS Proteins / Q000737:chemistry / Q000266:history* / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism
chemical_list: D020710:RGS Proteins