[Study on the expression of Eotaxin and the role of histamine in allergic rhinitis].
OBJECTIVE
To explore the expression of Eotaxin and the effect of histamine in allergic rhinitis model (AR), and aim to explore the pathogenesis of AR.


METHODS
The AR models were established by application of ovum albumin in rats. The expression of Eotaxin in nasal mucosa, serum and nasal cavity lavage fluid, were observed before and after treatment of histamine or its antagonist by immunochemistry, RT-PCR and ELISA technique.


RESULTS
The expression of Eotaxin in nasal lavage fluid and nasal mucosa increased after treatment of histamine (P < 0.05). Contrarily, the expression of Eotaxin in nasal lavage fluid, nasal mucosa and serum decreased after treatment of the antagonist of histamine.


CONCLUSIONS
Both histamine and its receptor can involve in the pathogenesis of AR by affecting the expression of Eotaxin.
Yan
Zhiqiang
Z
Department of Otolaryngology, 97th Hospital of PLA, Xuzhou, 221004, China. yanzhiq2000@yahoo.com.cn
Zhang
Ruxin
R
Yu
Shaoqing
S
Wu
Geping
G
D000818:Animals; D054413:Chemokine CCL11 / Q000096:biosynthesis / Q000378:metabolism*; D005260:Female; D006632:Histamine / Q000378:metabolism*; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism* / Q000473:pathology; D006255:Rhinitis, Allergic, Seasonal / Q000378:metabolism* / Q000473:pathology
D054413:Chemokine CCL11; D006632:Histamine