Gliosis in the amygdala following myocardial infarction in the rat.
We observed gliosis with cell death in the rat amygdala 3 and 14 days after myocardial infarction (MI). Cresyl violet-positive neurons had condensed cytoplasm, and Fluoro-Jade B-positive cells were detected in the amygdala 14 days, not 3 days, after MI. Only a few glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes and ionized calcium-binding adapter molecule 1 (Iba-1)-immunoreactive microglia showed activated form; hypertrophied cytoplasm, and highly ramified and retracted processes of astrocytes and microglia in the amygdala at 3 days after MI, respectively. At 14 days after MI, many astrocytes and most of microglia showed activated forms. These results suggest that MI may induce neuronal death and reactive gliosis in the amygdala.
Bae
Eunjoo
E
Department of Pediatrics, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, South Korea.
Hwang
In Koo
IK
Yoo
Ki-Yeon
KY
Han
Tae Hee
TH
Lee
Choong Hyun
CH
Choi
Jung Hoon
JH
Yi
Sun Shin
SS
Lee
So Yeong
SY
Ryu
Pan Dong
PD
Yoon
Yeo Sung
YS
Won
Moo-Ho
MH
D000679:Amygdala / Q000276:immunology / Q000473:pathology*; D000818:Animals; D001253:Astrocytes / Q000473:pathology; D001402:B-Lymphocytes / Q000473:pathology; D002135:Calcium-Binding Proteins / Q000032:analysis; D016923:Cell Death; D003593:Cytoplasm / Q000473:pathology; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D005911:Gliosis / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D008285:Major Histocompatibility Complex; D008840:Microfilament Proteins; D009203:Myocardial Infarction / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D009206:Myocardium / Q000473:pathology; D009474:Neurons / Q000276:immunology / Q000473:pathology; D051381:Rats; D013997:Time Factors
C100745:Aif1 protein, rat; D002135:Calcium-Binding Proteins; D005904:Glial Fibrillary Acidic Protein; D008840:Microfilament Proteins