New xanthate-based radical cyclization onto alkynes.
To bypass the failure of radical cyclization involving a xanthate transfer on alkynes, a new reductive cyclization strategy has been completed with the use of a stoichiometric amount of dilauroyl peroxide in isopropanol. When the starting xanthates are prepared via a Ugi 4-component reaction with propargylamine, exomethylene lactams are formed in good yields.
El Kaïm
Laurent
L
Laboratoire Chimie et Procédés, UMR 7652, Ecole Nationale Supérieure des Techniques Avancées, 32 Bd Victor, 75015 Paris, France. laurent.elkaim@ensta.fr
Grimaud
Laurence
L
Miranda
Luis D
LD
Vieu
Emilie
E
Cano-Herrera
M-Angeles
MA
Perez-Labrada
Karel
K