[Killer cell immunoglobin-like receptor and its ligand gene polymorphisms in Hunan Han patients with type 1 diabetes].
OBJECTIVE
To investigate the association of Killer cell immunoglobin-like receptor (KIR) gene and KIRs'ligand (HLA-C) gene polymorphisms with type 1 diabetes (T1DM).


METHODS
Using polymerase chain reaction-sequence specific primer (PCR-SSP) to detect KIR and HLA-C genotype in 180 T1DM patients and 199 healthy controls from Hunan Han population.


RESULTS
(1) The frequencies of KIR 2DL1 (98.9% vs 92.0%, OR = 7.78, P = 0.002), 3DL1 (94.3% vs 86.4%, OR = 2.67, P = 0.009) and 2DS4 (83.9% vs 70.9%, OR = 2.14, P = 0.003) were significantly higher in T1DM patients than those in the controls. (2) There were no differences in the frequencies of HLA-C1 and HLA-C2 between the patients and the controls, but the frequency of HLAC1+/C2+ (3.9% vs 9.6%, OR = 0.38, P = 0.03) was significantly lower in the T1DM patients. (3) The combination KIR2DL1-/HLA-C2-(0.6% vs 6.0%, OR = 0.087, P = 0.003) and KIR 2DS1-/HLA-C2-(53.3% vs 64.8%, OR = 0.62, P = 0.023) was significantly lower in the T1DM patients.


CONCLUSIONS
The KIR gene polymorphism and KIR/HLA-C gene compatibility are associated with T1DM.
Tan
Yu-Yu
YY
Institute of Metabolism and Endocrinology, Diabetic Center, Metabolic Syndrome Research Center, Second Xiangya Hospital, Central South University, Changsha 410011, China.
Lin
Jian
J
Huang
Gan
G
Tang
Wei-Li
WL
Sedimbi
Saikiran K
SK
Sanjeevi
Carani B
CB
Zhou
Zhi-Guang
ZG
D000293:Adolescent; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D015236:HLA-C Antigens / Q000235:genetics*; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism; D008024:Ligands; D008297:Male; D011110:Polymorphism, Genetic; D054342:Receptors, KIR2DL1 / Q000235:genetics*; D013601:T-Lymphocytes / Q000378:metabolism
D015236:HLA-C Antigens; C093100:KIR2DL1 protein, human; D008024:Ligands; D054342:Receptors, KIR2DL1