title: [The relationship between hepatitis B virus infection and the incidence of pancreatic cancer: a retrospective case-control study].
abstract: OBJECTIVE
  An association between past history of hepatitis B virus (HBV) infection and pancreatic cancer (PC) has recently been reported. We investigated whether HBV and hepatitis C virus (HCV) infections are associated with the development of PC in Korea.
  
  
  METHODS
  We retrospectively recruited patients with PC and sex- and, age-matched control patients with stomach cancer (SC) during the previous 5 years. Serum HBsAg and anti-HCV were examined, and data on smoking, alcohol intake, diabetes, and the history of chronic pancreatitis (CP) were collected.
  
  
  RESULTS
  A total of 506 PC and 1008 SC were enrolled, with respectively 58.1% and 97.3% of these cases being confirmed histologically. The mean age and sex ratio (male:female) were 63.5 years and 1.5:1 in the PC patients and 63.9 years and 1.5:1 in the SC patients respectively (P>0.05). The odds ratios (95% confidence interval, 95% CI) in univariate analysis were 0.90 (0.52-1.56; P=0.70) for HBsAg, 1.87 (0.87-4.01; P=0.11) for anti-HCV, 2.66 (2.04-3.48; P<0.001) for the presence of diabetes, 2.30 (1.83-2.90; P<0.001) for smoking, 1.14 (0.89-1.46; P=0.31) for alcohol intake, and 4.40 (1.66-11.66; P=0.003) for the history of CP. Independent risk factors for PC were presence of diabetes (OR, 2.67; 95% CI, 2.00-3.56; P<0.001), smoking (OR, 2.49; 95% CI, 1.93-3.21; P<0.001) and history of CP (OR, 4.60; 95% CI, 1.56-13.53; P=0.006).
  
  
  CONCLUSIONS
  There was no significant association between seropositivity for HBsAg or anti-HCV and PC. Further studies are warranted to clarify the association between HBV infection and PC in regions where HBV is endemic.
authors.affiliation: Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
authors.forename: Seung Goun
authors.initials: SG
authors.lastname: Hong
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Young Sun
authors.initials: YS
authors.lastname: Lee
authors.forename: Eileen
authors.initials: E
authors.lastname: Yoon
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Jin Ki
authors.initials: JK
authors.lastname: Hwang
authors.forename: Eun Suk
authors.initials: ES
authors.lastname: Jung
authors.forename: Moon Kyung
authors.initials: MK
authors.lastname: Joo
authors.forename: Young Kul
authors.initials: YK
authors.lastname: Jung
authors.forename: Jong Eun
authors.initials: JE
authors.lastname: Yeon
authors.forename: Jong Jae
authors.initials: JJ
authors.lastname: Park
authors.forename: Jae Seon
authors.initials: JS
authors.lastname: Kim
authors.forename: Young Tae
authors.initials: YT
authors.lastname: Bak
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Byun
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003627:Data Interpretation, Statistical; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000175:diagnosis; D006526:Hepatitis C / Q000150:complications / Q000175:diagnosis; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors