title: [Study on the expression of Eotaxin and the role of histamine in allergic rhinitis].
abstract: OBJECTIVE
  To explore the expression of Eotaxin and the effect of histamine in allergic rhinitis model (AR), and aim to explore the pathogenesis of AR.
  
  
  METHODS
  The AR models were established by application of ovum albumin in rats. The expression of Eotaxin in nasal mucosa, serum and nasal cavity lavage fluid, were observed before and after treatment of histamine or its antagonist by immunochemistry, RT-PCR and ELISA technique.
  
  
  RESULTS
  The expression of Eotaxin in nasal lavage fluid and nasal mucosa increased after treatment of histamine (P < 0.05). Contrarily, the expression of Eotaxin in nasal lavage fluid, nasal mucosa and serum decreased after treatment of the antagonist of histamine.
  
  
  CONCLUSIONS
  Both histamine and its receptor can involve in the pathogenesis of AR by affecting the expression of Eotaxin.
authors.affiliation: Department of Otolaryngology, 97th Hospital of PLA, Xuzhou, 221004, China. yanzhiq2000@yahoo.com.cn
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Yan
authors.forename: Ruxin
authors.initials: R
authors.lastname: Zhang
authors.forename: Shaoqing
authors.initials: S
authors.lastname: Yu
authors.forename: Geping
authors.initials: G
authors.lastname: Wu
mesh_terms: D000818:Animals; D054413:Chemokine CCL11 / Q000096:biosynthesis / Q000378:metabolism*; D005260:Female; D006632:Histamine / Q000378:metabolism*; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism* / Q000473:pathology; D006255:Rhinitis, Allergic, Seasonal / Q000378:metabolism* / Q000473:pathology
chemical_list: D054413:Chemokine CCL11; D006632:Histamine