Distinct mechanisms for the pro-apoptotic conformational transition and alkaline transition in cytochrome c.
We demonstrate for the first time that cytochrome c undergoes a distinct pathway in the alkaline conformational transition from its pro-apoptotic conformational transition, which may have important functional consequences in vivo.
Ying
Tianlei
T
Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.
Wang
Zhong-Hua
ZH
Zhong
Fangfang
F
Tan
Xiangshi
X
Huang
Zhong-Xian
ZX
D017209:Apoptosis; D045304:Cytochromes c / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008672:Metals, Alkali / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D009154:Mutation; D011487:Protein Conformation
D008672:Metals, Alkali; D045304:Cytochromes c