Mechanical properties and water vapour permeability of film from Haruan (Channa striatus) and fusidic acid spray for wound dressing and wound healing.
Aerosol is a new dosage form for wound dressing and wound healing. Concentrate of aerosols which were prepared for wound dressing and wound healing will produced films after sprayed onto the surface of wounds. The aim of this study is to evaluate the mechanical and water vapour permeability properties of the films from the aerosol concentrates. Film forming dispersions contained Haruan extract and Fusidic acid as the active ingredients, hydroxypropyl methylcellulose (HPMC) as polymer and polyethylene glycol (PEG) 400, glycerin and propylene glycol as plasticizers. Haruan extract is used to promote healing and Fusidic acid is added in formula as antibiotic to prevent the infections. The films were prepared by using casting technique. Based on the results, it is concluded that films produced from Formula E1, E2 and F4 possessed good elongation at break but low tensile strength. All Formula E, Formula F4 and F5 were permeable but Formula F5 was brittle and would peel off by themselves from the Petri dish.
Febriyenti
Faculty of Pharmacy, Andalas University, Padang 25163, Indonesia.
Noor
Azmin Mohd
AM
Bai
Saringat Bin
SB
D000336:Aerosols / Q000737:chemistry*; D004337:Drug Carriers / Q000008:administration & dosage; D004339:Drug Compounding / Q000379:methods; D004548:Elasticity; D005672:Fusidic Acid / Q000008:administration & dosage*; D065347:Hypromellose Derivatives; D008747:Methylcellulose / Q000031:analogs & derivatives; D009779:Occlusive Dressings; D010539:Permeability; D010968:Plasticizers; D011092:Polyethylene Glycols; D011108:Polymers / Q000737:chemistry; D013227:Steam; D013718:Tensile Strength; D014945:Wound Healing
D000336:Aerosols; D004337:Drug Carriers; D010968:Plasticizers; D011108:Polymers; D013227:Steam; C549592:haruan extract; D065347:Hypromellose Derivatives; D011092:Polyethylene Glycols; D005672:Fusidic Acid; D008747:Methylcellulose