Organocatalyzed enantioselective one-pot three-component access to indoloquinolizidines by a Michael addition-Pictet-Spengler sequence.
The enantioselective three-component Michael addition-Pictet-Spengler sequence of beta-ketoesters 1, alpha,beta-unsaturated aldehydes 2 and tryptamines 4 represents a facile and rapid one-pot access to highly substituted indoloquinolizidines in moderate to excellent yields and good to excellent enantioselectivities.
Wu
Xiaoyu
X
Department of Chemistry, Shanghai University, 99 Shangda Rd, Shanghai 200444, People's Republic of China. wuxy@shu.edu.cn
Dai
Xiaoyang
X
Nie
Linlin
L
Fang
Huihui
H
Chen
Jie
J
Ren
Zhongjiao
Z
Cao
Weiguo
W
Zhao
Gang
G
D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D009930:Organic Chemicals / Q000737:chemistry; D054837:Quinolizidines / Q000737:chemistry*; D013237:Stereoisomerism
D007211:Indoles; D009930:Organic Chemicals; D054837:Quinolizidines