title: [Statins and muscular side-effects].
abstract: Statins are effective in the treatment of hypercholesterolemia for primary and secondary prevention of cardiovascular disease. While most side effects of statins are mild and transient, muscular symptoms are relatively common (5 to 10% of patients), but rarely serious (myositis, rhabdomyolysis). In cases of myopathy, the severity of symptoms and the determination of CK (creatine kinase) determine whether discontinuation of statin is necessary. Alternative strategies are also suggested. This article reviews suggestions on the management of these complaints that are a challenge in clinical practice.
authors.affiliation: Consultation des lipides et de prévention cardiovasculaire, PMU, Lausanne.
authors.forename: Christine
authors.initials: C
authors.lastname: Brosteaux
authors.forename: Juan
authors.initials: J
authors.lastname: Ruiz
authors.forename: Thierry
authors.initials: T
authors.lastname: Buclin
authors.forename: Thierry
authors.initials: T
authors.lastname: Kuntzer
authors.forename: Nicolas
authors.initials: N
authors.lastname: Rodondi
mesh_terms: D000367:Age Factors; D000369:Aged, 80 and over; D000465:Algorithms; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001384:Azetidines / Q000008:administration & dosage / Q000627:therapeutic use; D001706:Biopsy; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D003402:Creatine Kinase / Q000097:blood; D000069438:Ezetimibe; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology; D009135:Muscular Diseases / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D009220:Myositis / Q000139:chemically induced; D010146:Pain / Q000139:chemically induced; D011322:Primary Prevention; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D012206:Rhabdomyolysis / Q000139:chemically induced; D055502:Secondary Prevention; D012737:Sex Factors; D014451:Ubiquinone / Q000172:deficiency
chemical_list: D000924:Anticholesteremic Agents; D001384:Azetidines; D014451:Ubiquinone; D003402:Creatine Kinase; D000069438:Ezetimibe