Progesterone receptor agonists and antagonists as anticancer agents.
Progesterone is a major female steroid hormone produced by the ovarian corpus luteum and by the placental syncytiotrophoblast during the second trimester. The biological effects of this steroid hormone are mediated by the ubiquitously expressed progesterone receptor. The exact link between progesterone and female reproductive organ cancer is a controversial issue with various cross-talks. The present review summarizes recent trends in the development of some (anti)progestagen in the cure and management of breast and uterine cancers.
Chakraborty
Ajanta
A
Molecular Endocrinology Laboratory, Department of Biotechnology, Indian Institute of Technology Roorkee, Roorkee 247667, Uttarakhand, India.
Chatterjee
Shamba
S
Roy
Partha
P
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D004963:Estrenes / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D004967:Estrogens / Q000378:metabolism; D005260:Female; D006801:Humans; D010080:Oxazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D011374:Progesterone / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D011980:Receptors, Progesterone / Q000819:agonists / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014594:Uterine Neoplasms / Q000188:drug therapy*; D005466:Fluorocarbons
D000970:Antineoplastic Agents; D004963:Estrenes; D004967:Estrogens; D010080:Oxazoles; D011374:Progesterone; D011720:Pyrazoles; D011980:Receptors, Progesterone; C419162:lonaprisan; D005466:Fluorocarbons