title: [Study on correlation of JAK/STAT signal pathway with progression and prognosis in hepatocellular carcinoma].
abstract: OBJECTIVE
  To investigate the expression of JAK/STAT signal pathway in human hepatocellular carcinoma, and to evaluate its clinical significance in the progression and prognosis in hepatocellular carcinoma.
  
  
  METHODS
  196 patients with hepatocellular carcinoma were examined for the expression of JAK-1 protein and STAT-3 protein by SABC immunohistochemistry.
  
  
  RESULTS
  The positive expression rates of JAK-1 protein and STAT-3 protein in patients with hepatocellular carcinoma were significantly higher than those in 20 cases of normal liver tissue (P=0.02 and 0.01, respectively). There was no significant relation between the positive expression rates of JAK-1 protein and STAT-3 protein and patients'sex, age, tumor size, and cirrhosis of the hepatocellular carcinoma tissues (all P>0.05). The JAK-1 protein and STAT-3 protein were expressed more frequently in hepatocellular carcinoma tissues with incomplete capsule (P=0.01 and 0.008, respectively), venous tumor emboli (both P=0.02), poorly differentiated (P=0.01 and 0.009, respectively) or clinical III-IV stage (P=0.02 and 0.008, respectively) than in those with complete capsule, no venous tumor emboli, maturely differentiated or clinical I-II stage. Cox proportional hazard regression model analysis indicated that the expression of JAK-1 protein and STAT-3 protein was significantly correlated with the prognosis of patients with hepatocellular carcinoma.
  
  
  CONCLUSIONS
  The results suggest that the over-expression of JAK/STAT signal pathway may be an important feature of hepatocellular carcinoma.
authors.affiliation: Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China. zbpbzxl@sina.com.cn
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: De-wu
authors.initials: DW
authors.lastname: Zhong
authors.forename: Qun-wei
authors.initials: QW
authors.lastname: Wang
authors.forename: Xiong-ying
authors.initials: XY
authors.lastname: Miao
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Dai
authors.forename: Chun
authors.initials: C
authors.lastname: Liu
authors.forename: Kai-hua
authors.initials: KH
authors.lastname: Pan
mesh_terms: D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053613:Janus Kinase 1 / Q000378:metabolism*; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D050796:STAT3 Transcription Factor; D053613:Janus Kinase 1