title: Applying mass spectrometry based proteomic technology to advance the understanding of multiple myeloma.
abstract: Multiple myeloma (MM) is the second most common hematological malignancy in adults. It is characterized by clonal proliferation of terminally differentiated B lymphocytes and over-production of monoclonal immunoglobulins. Recurrent genomic aberrations have been identified to contribute to the aggressiveness of this cancer. Despite a wealth of knowledge describing the molecular biology of MM as well as significant advances in therapeutics, this disease remains fatal. The identification of biomarkers, especially through the use of mass spectrometry, however, holds great promise to increasing our understanding of this disease. In particular, novel biomarkers will help in the diagnosis, prognosis and therapeutic stratification of MM. To date, results from mass spectrometry studies of MM have provided valuable information with regards to MM diagnosis and response to therapy. In addition, mass spectrometry was employed to study relevant signaling pathways activated in MM. This review will focus on how mass spectrometry has been applied to increase our understanding of MM.
authors.affiliation: Department of Laboratory Hematology, University Health Network, Toronto, Canada.
authors.forename: Johann
authors.initials: J
authors.lastname: Micallef
authors.forename: Moyez
authors.initials: M
authors.lastname: Dharsee
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.forename: Suzanne
authors.initials: S
authors.lastname: Ackloo
authors.forename: Ken
authors.initials: K
authors.lastname: Evans
authors.forename: Luqui
authors.initials: L
authors.lastname: Qiu
authors.forename: Hong
authors.initials: H
authors.lastname: Chang
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D006801:Humans; D013058:Mass Spectrometry; D009101:Multiple Myeloma / Q000378:metabolism* / Q000473:pathology; D040901:Proteomics; D015398:Signal Transduction
chemical_list: D014408:Biomarkers, Tumor