title: Osseointegration of anodized titanium implants coated with poly(lactide-co-glycolide)/basic fibroblast growth factor by electrospray.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the effect of basic fibroblast growth factor (bFGF) in combination with a biodegradable polymer coated onto titanium implants. The implants were inserted in rabbit tibiae, and bone growth was examined by histomorphometric analysis.
  
  
  METHODS
  Forty-eight threaded anodized implants were inserted into the tibiae of 12 rabbits. After 12 weeks of healing, an evaluation was made by light microscopy and computerized image analysis. A total of 56 anodized titanium implants were prepared as follows: group 1 was anodized under 300 V; group 2 was anodized then coated with 0.02 mL poly(lactide-co-glycolide) (PLGA) nanoparticles; group 3 was anodized then coated with 0.02 mL PLGA/bFGF nanoparticles (10 ng bFGF); and group 4 was anodized then coated with 0.2 mL PLGA/bFGF nanoparticles (100 ng bFGF).
  
  
  RESULTS
  Nanosized particles were observed on the coated implant surfaces. The mean diameter of the nanoparticles was 268.6 +/- 93.2 nm. The mean bone-to-implant contact (BIC) percentage in group 4 (44.7%) was significantly greater than that seen in groups 1 (31.4%) and 2 (33.6%) (P < .05).
  
  
  CONCLUSIONS
  The results of this preliminary study show that coating a titanium implant with PLGA incorporated with bFGF by electrospray may stimulate bone formation adjacent to the surface of an implant inserted in bone.
authors.affiliation: Department of Prosthodontics and Dental Research Institute, College of Dentistry Seoul National University, Seoul, South Africa. young21c@snu.ac.kr
authors.forename: Su Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Jai Young
authors.initials: JY
authors.lastname: Koak
authors.forename: Seong Joo
authors.initials: SJ
authors.lastname: Heo
authors.forename: Seong Kyun
authors.initials: SK
authors.lastname: Kim
authors.forename: Seung Jin
authors.initials: SJ
authors.lastname: Lee
authors.forename: Seung Yeon
authors.initials: SY
authors.lastname: Nam
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D015921:Dental Implants; D003764:Dental Materials / Q000737:chemistry*; D017267:Dental Prosthesis Design; D055664:Electrochemical Techniques; D016222:Fibroblast Growth Factor 2 / Q000627:therapeutic use*; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry; D016348:Osseointegration / Q000502:physiology*; D010012:Osteogenesis / Q000502:physiology; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016062:Porosity; D011817:Rabbits; D013499:Surface Properties; D013977:Tibia / Q000601:surgery; D014025:Titanium / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D015921:Dental Implants; D003764:Dental Materials; D016222:Fibroblast Growth Factor 2; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D014025:Titanium