Prevention of gestational diabetes: feasibility issues for an exercise intervention in obese pregnant women.
OBJECTIVE
To examine the feasibility of an individualized exercise program to prevent gestational diabetes mellitus (GDM) in obese pregnant women.


METHODS
The study was a pilot randomized controlled trial with obese pregnant women (intervention group, individualized exercise program [n = 25]; control group, usual care [n = 25]). Average weekly energy expenditure (MET hours per week and kilocalories per week) of exercise-specific activity was assessed during pregnancy using the Pregnancy Physical Activity Questionnaire. Fasting glucose and insulin and homeostasis model assessment of insulin resistance (HOMA-IR) were assessed at baseline and 20, 28, and 36 weeks' gestation.


RESULTS
Of the women in the intervention group, 16 of 22 (73%) achieved more than 900 kcal/week of exercise-based activity at 28 weeks compared with 8 of 19 women in the control group (42%), P = 0.047. However, insulin resistance (HOMA-IR) did not differ between the groups.


CONCLUSIONS
This intervention was feasible and prompted a modest increase in physical activity. However, we are not confident that this intervention would be sufficient to prevent GDM.
Callaway
Leonie K
LK
Royal Brisbane Clinical School, Royal Brisbane and Women's Hospital, Brisbane, Australia. l.callaway@uq.edu.au
Colditz
Paul B
PB
Byrne
Nuala M
NM
Lingwood
Barbara E
BE
Rowlands
Ingrid J
IJ
Foxcroft
Katie
K
McIntyre
H David
HD
D016640:Diabetes, Gestational / Q000517:prevention & control*; D002149:Energy Intake; D004734:Energy Metabolism; D015444:Exercise; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008019:Life Style; D009043:Motor Activity; D009765:Obesity / Q000178:diet therapy*; D010865:Pilot Projects; D011247:Pregnancy; D011795:Surveys and Questionnaires; D016896:Treatment Outcome