title: Bone invasion by squamous cell carcinoma in situ (Bowen's disease) of the finger during treatment with imiquimod 5% cream: case report.
abstract: Imiquimod 5% cream is known as an alternative treatment option for squamous cell carcinoma in situ (SCCIS), frequently termed Bowen's disease. Although imiquimod cream has been reported by many authors to treat SCCIS successfully, its efficacy and safety have not been fully established. The authors experienced a case in which ray amputation was necessary because of bone invasion by SCCIS in a finger being treated with imiquimod cream.
authors.affiliation: Department of Orthopaedics, Hand and Upper Extremity Service, Seoul National University Bundang Hospital, Seongnam, Korea. hsgong@snu.ac.kr
authors.forename: Hyun Sik
authors.initials: HS
authors.lastname: Gong
authors.forename: Jae Hwan
authors.initials: JH
authors.lastname: Cho
authors.forename: Young Hak
authors.initials: YH
authors.lastname: Roh
authors.forename: Moon Sang
authors.initials: MS
authors.lastname: Chung
authors.forename: Goo Hyun
authors.initials: GH
authors.lastname: Baek
mesh_terms: D000368:Aged; D000634:Aminoquinolines / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001913:Bowen's Disease / Q000188:drug therapy* / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000473:pathology*; D005384:Finger Joint / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005385:Fingers; D006801:Humans; D000077271:Imiquimod; D008279:Magnetic Resonance Imaging; D008297:Male; D009361:Neoplasm Invasiveness; D011859:Radiography; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology*
chemical_list: D000634:Aminoquinolines; D000970:Antineoplastic Agents; D000077271:Imiquimod