title: New-generation Skulachev ions exhibiting nephroprotective and neuroprotective properties.
abstract: A mitochondria-targeted chimeric compound consisting of a rhodamine derivative linked to a plastoquinone molecule (10-(6'-plastoquinonyl)decylrhodamine, SkQR1) was studied under conditions of acute brain or kidney damage. A protective effect of this compound was demonstrated in a model of focal brain ischemia, rat kidney ischemia/reperfusion, myoglobinuria (rhabdomyolysis, or crush syndrome), and pyelonephritis. We found that a single intraperitoneal injection of SkQR1 diminishes the size of the ischemic zone in the brain and improves performance of a test characterizing neurological deficit in ischemic animals. Control substance not containing plastoquinone appeared to be not neuroprotective. The data show that SkQR1 is a nephroprotectant and neuroprotectant, which can be due to the antioxidative action of this Skulachev cation.
authors.affiliation: Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119992, Russia.
authors.forename: E Y
authors.initials: EY
authors.lastname: Plotnikov
authors.forename: D N
authors.initials: DN
authors.lastname: Silachev
authors.forename: A A
authors.initials: AA
authors.lastname: Chupyrkina
authors.forename: M I
authors.initials: MI
authors.lastname: Danshina
authors.forename: S S
authors.initials: SS
authors.lastname: Jankauskas
authors.forename: M A
authors.initials: MA
authors.lastname: Morosanova
authors.forename: E V
authors.initials: EV
authors.lastname: Stelmashook
authors.forename: A K
authors.initials: AK
authors.lastname: Vasileva
authors.forename: E S
authors.initials: ES
authors.lastname: Goryacheva
authors.forename: Y A
authors.initials: YA
authors.lastname: Pirogov
authors.forename: N K
authors.initials: NK
authors.lastname: Isaev
authors.forename: D B
authors.initials: DB
authors.lastname: Zorov
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism / Q000503:physiopathology; D042541:Intracellular Space / Q000187:drug effects / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009212:Myoglobinuria / Q000378:metabolism / Q000503:physiopathology; D009422:Nervous System Diseases / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects; D010971:Plastoquinone / Q000031:analogs & derivatives* / Q000494:pharmacology; D011704:Pyelonephritis / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D015427:Reperfusion Injury / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D012235:Rhodamines / Q000494:pharmacology*
chemical_list: C534903:10-(6'-plastoquinonyl) decylrhodamine 19; D018696:Neuroprotective Agents; D017382:Reactive Oxygen Species; D012235:Rhodamines; D010971:Plastoquinone