Peptides for in vivo target-specific cancer imaging.
Molecular imaging comprises non-invasive monitoring of functional and spatiotemporal processes at molecular and cellular levels in living systems. Advanced imaging techniques can monitor such processes. Peptide receptors over-expressed in tumours can be targeted by peptides conjugated to radionuclides, near-infrared fluorochromes, metallic nanoparticles or quantum dots for target-specific cancer imaging.
Ferro-Flores
G
G
Department of Radioactive Materials. Instituto Nacional de Investigaciones Nucleares, Estado de México, Mexico. ferro_flores@yahoo.com.mx
Ramírez
F de M
Fde M
Meléndez-Alafort
L
L
Santos-Cuevas
C L
CL
D000818:Animals; D005456:Fluorescent Dyes / Q000737:chemistry; D015696:Gene Products, tat / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000639:trends; D057054:Molecular Imaging / Q000379:methods* / Q000639:trends; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000378:metabolism; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000378:metabolism; D049268:Positron-Emission Tomography / Q000379:methods / Q000639:trends; D045663:Quantum Dots; D018000:Receptors, Peptide / Q000378:metabolism; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods / Q000639:trends
D005456:Fluorescent Dyes; D015696:Gene Products, tat; D009842:Oligopeptides; D010455:Peptides; D018000:Receptors, Peptide; C047981:arginyl-glycyl-aspartic acid