title: Novel benzimidazole-pyrimidine conjugates as potent antitumor agents.
abstract: As a continuation to our previous work in synthesizing antitumor benzimidazoles, a series of 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-(substituted)-6-phenylpyrimidine-5-carbonitriles was synthesized. Evaluation of the synthesized compounds for their in vitro cytotoxic activity against twelve cell lines namely, Cervical carcinoma (KB), Ovarial carcinoma (SK OV-3), CNS cancer (SF-268), Non small lung cancer (NCI H460), Colonadenocarcinoma (RKOP27), Leukaemia (HL60, U937, K562), Melanoma (G361, SK-MEL-28) and Neuroblastoma (GOTO, NB-1) revealed their marked potency when compared with known anticancer drugs.
authors.affiliation: Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries Research, National Research Centre, Cairo, Egypt.
authors.forename: Heba T
authors.initials: HT
authors.lastname: Abdel-Mohsen
authors.forename: Fatma A F
authors.initials: FA
authors.lastname: Ragab
authors.forename: Mostafa M
authors.initials: MM
authors.lastname: Ramla
authors.forename: Hoda I
authors.initials: HI
authors.lastname: El Diwani
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007928:Lethal Dose 50; D011743:Pyrimidines / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D001562:Benzimidazoles; D011743:Pyrimidines; C031000:benzimidazole; C030986:pyrimidine