Application of poly(amidoamine) dendrimers for use in bionanomotor systems.
The study and utilization of bionanomotors represents a rapid and progressing field of nanobiotechnology. Here, we demonstrate that poly(amidoamine) (PAMAM) dendrimers are capable of supporting heavy meromyosin dependent actin motility of similar quality to that observed using nitrocellulose, and that microcontact printing of PAMAM dendrimers can be exploited to produce tracks of active myosin motors leading to the restricted motion of actin filaments across a patterned surface. These data suggest that the use of dendrimer surfaces will increase the applicability of using protein biomolecular motors for nanotechnological applications.
Kolli
Madhukar B
MB
Cell Differentiation and Development Center, Joan C. Edwards School of Medicine, Huntington, West Virginia, USA.
Day
B Scott
BS
Takatsuki
Hideyo
H
Nalabotu
Siva K
SK
Rice
Kevin M
KM
Kohama
Kazuhiro
K
Gadde
Murali K
MK
Kakarla
Sunil K
SK
Katta
Anjaiah
A
Blough
Eric R
ER
D000818:Animals; D002417:Cattle; D003101:Collodion / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry*; D004560:Electricity; D009068:Movement; D009218:Myosins / Q000378:metabolism; D036103:Nanotechnology / Q000379:methods*; D013499:Surface Properties; D017971:Tin Compounds / Q000737:chemistry
D050091:Dendrimers; C104700:PAMAM Starburst; D017971:Tin Compounds; C109984:indium tin oxide; D003101:Collodion; D009218:Myosins