Nhatrangins A and B, aplysiatoxin-related metabolites from the marine cyanobacterium Lyngbya majuscula from Vietnam.
Two polyketide metabolites, nhatrangins A (1) and B (2), were isolated from a Vietnamese collection of Lyngbya majuscula. These compounds are related to the aplysiatoxin series of metabolites, which have also been isolated from this species of marine cyanobacterium. The use of 900 MHz cryoprobe NMR allowed the elucidation of the 2D structure of 1 from approximately 0.3 mg of compound. LC-MS analysis was utilized to direct the isolation of additional material as well as the isolation of 2. Conformational analysis was completed using J-based coupling constant analysis and selective NOE experiments.
Chlipala
George E
GE
Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, USA.
Pham
Huu Tri
HT
Nguyen
Van Hung
VH
Krunic
Aleksej
A
Shim
Sang Hee
SH
Soejarto
D Doel
DD
Orjala
Jimmy
J
D000458:Cyanobacteria / Q000737:chemistry; D008235:Lyngbya Toxins / Q000737:chemistry / Q000302:isolation & purification*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014744:Vietnam
D008235:Lyngbya Toxins; C549735:nhatrangin A; C549736:nhatrangin B; C006610:aplysiatoxin