Oral administration of acidic xylooligosaccharides prevents the development of atopic dermatitis-like skin lesions in NC/Nga mice.
We examined whether two types of xylooligosaccharides (neutral or acidic xylooligosaccharides) derived from hardwood kraft pulp ameliorate the development of atopic dermatitis (AD)-like skin lesions induced by repeated application of picryl chloride (PiCl) in NC/Nga mice. Oral administration of acidic xylooligosaccharides at a daily dose of 100 mg/kg significantly prevented the development of AD-like skin lesions. Serum histamine level was significantly suppressed, but serum total IgE level was not significantly suppressed. Moreover, the secretion of inflammatory cytokine IL-12 from splenic lymphocytes was significantly suppressed. On the other hand, neutral xylooligosaccharides showed no significant preventive effect on the development of AD-like symptoms. These results suggest that oral administration of acidic xylooligosaccharides may be effective in preventing the development of AD-like skin disease and one of the mechanisms is the suppressive effect on IL-12.
Ohbuchi
Takayuki
T
R & D Laboratories Headquarters, Oji Paper Co., Ltd., Tokyo, Japan. takayuki-ohbuchi@ojipaper.co.jp
Sakaino
Makoto
M
Takahashi
Tetsunari
T
Azumi
Naoya
N
Ishikawa
Kotaro
K
Kawazoe
Sadahiro
S
Kobayashi
Yukiko
Y
Kido
Yasuhiro
Y
D000143:Acids; D000284:Administration, Oral; D000818:Animals; D002478:Cells, Cultured; D003876:Dermatitis, Atopic / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D006632:Histamine / Q000097:blood; D007073:Immunoglobulin E / Q000097:blood; D018664:Interleukin-12 / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects; D019684:Magnoliopsida; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009844:Oligosaccharides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects* / Q000276:immunology / Q000473:pathology; D013154:Spleen / Q000166:cytology; D014934:Wood
D000143:Acids; D009844:Oligosaccharides; D010936:Plant Extracts; D018664:Interleukin-12; D007073:Immunoglobulin E; D006632:Histamine