Can animal models of disease reliably inform human studies?
H. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials.
van der Worp
H Bart
HB
Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands. H.B.vanderWorp@umcutrecht.nl
Howells
David W
DW
Sena
Emily S
ES
Porritt
Michelle J
MJ
Rewell
Sarah
S
O'Collins
Victoria
V
Macleod
Malcolm R
MR
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D017594:Publication Bias; D015203:Reproducibility of Results; D057170:Translational Research, Biomedical