The c-src homologue Src64B is sufficient to activate the Drosophila cellular immune response.
The Drosophila larval cellular immune response involves cells (haemocytes) that can be recruited from a haematopoietic organ known as the lymph gland, as well as a sessile population of cells found just underneath the larval cuticle arranged in a segmental pattern. Overexpression of the Drosophila c-src homologue Src64B disrupts the sessile-haemocyte banding pattern. Though Src64B overexpression induced the formation of specialized haemocytes known as lamellocytes, its hyperactivation had no effect on circulating plasmatocyte concentration. Also, there is evidence of non-autonomous regulation as Src64B activity was observed in non-overexpressing plasmatocytes. Finally, Src64B overexpression induced F-actin formation and Jun kinase activation in plasmatocytes.
Williams
Michael J
MJ
Institute of Biological and Environmental Sciences, University of Aberdeen, Aberdeen, UK. m.j.williams@abdn.ac.uk
D000199:Actins / Q000276:immunology; D000818:Animals; D029721:Drosophila Proteins / Q000096:biosynthesis* / Q000235:genetics; D004331:Drosophila melanogaster / Q000201:enzymology / Q000276:immunology*; D005260:Female; D006434:Hemocytes / Q000201:enzymology / Q000276:immunology*; D007111:Immunity, Cellular; D007113:Immunity, Innate; D048031:JNK Mitogen-Activated Protein Kinases / Q000378:metabolism; D007814:Larva / Q000201:enzymology / Q000276:immunology; D011505:Protein-Tyrosine Kinases / Q000096:biosynthesis* / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis* / Q000235:genetics
D000199:Actins; D029721:Drosophila Proteins; D011518:Proto-Oncogene Proteins; D011505:Protein-Tyrosine Kinases; C075699:Src64B protein, Drosophila; D048031:JNK Mitogen-Activated Protein Kinases