title: Influenza A (H1N1) pneumonia in an immunossupressed patient after heart transplantation.
abstract: The role of the immune response during Influenza H1N1 virus infection is not yet fully established, but it is believed that it decisively participates in the severity of the disease as well as in the development of acute respiratory distress syndrome. The role of immunomodulating therapies in the control of viral infections is not a consensus either, and data from the literature defining the indications for their use are lacking. The present report is, to our knowledge, the first on a heart transplant patient who developed H1N1 virus infection and had a favorable outcome, thus generating discussion on the real role of immunosuppressive therapy as a risk factor for the severe form of the disease.
authors.affiliation: Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil. fbacal@uol.com.br
authors.forename: Fernando
authors.initials: F
authors.lastname: Bacal
authors.forename: Luis Fernando
authors.initials: LF
authors.lastname: Seguro
authors.forename: Tania
authors.initials: T
authors.lastname: Ogawa
authors.forename: Sandrigo
authors.initials: S
authors.lastname: Mangini
authors.forename: Alfredo
authors.initials: A
authors.lastname: Fiorelli
authors.forename: Edimar
authors.initials: E
authors.lastname: Bocchi
mesh_terms: D005260:Female; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000276:immunology / Q000821:virology*; D008875:Middle Aged; D011024:Pneumonia, Viral / Q000209:etiology*; D012128:Respiratory Distress Syndrome / Q000517:prevention & control
chemical_list: D007166:Immunosuppressive Agents