[Autoimmune thyroid disorders and reproductive failures].
At recent ten years have concluded influence of thyroid autoantibodies in normal beginning, development and growing up of pregnancy. Changing in thyroid autoimmunity, even in the absence of evident thyroid dysfunction, is associated with an increased risk of subfertility. The disturbances in thyroid autoimmunity have associated with a significantly increased risk of recurrent pregnancy loss. Although of pathophysiologic mechanism is still not unclear has suggested that thyroid autoantibodies started abnormal immune response and following disturbances in maternal-fetal thyroid function. This can easily be prevented by systematic screening, for thyroid dysfunction and antibody presence during early gestation, followed by the administration of levothyroxine treatment.
Todorova-Ananieva
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D000022:Abortion, Spontaneous / Q000209:etiology*; D001323:Autoantibodies / Q000009:adverse effects* / Q000276:immunology; D001327:Autoimmune Diseases / Q000150:complications* / Q000276:immunology; D015551:Autoimmunity; D005260:Female; D006801:Humans; D011247:Pregnancy; D012307:Risk Factors; D013959:Thyroid Diseases / Q000150:complications* / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology* / Q000503:physiopathology
D001323:Autoantibodies