[Association of rs2298212 polymorphism in OX40 gene with coronary atherosclerotic disease in Chinese Han population].
OBJECTIVE
To study the association of the OX40 gene rs2298212G/A polymorphism with coronary atherosclerotic disease (CAD) in Chinese Han population.


METHODS
Five hundred and thirty six CAD patients and 544 age and ethnic matched controls of Chinese Han population were recruited from Qilu Hospital, Shandong University. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to genotype the selected single nucleotide polymorphism. Distributions of genotypic and allelic frequencies were analyzed by Chi-square test.


RESULTS
The distribution of genotypic and allelic frequencies have no significant differences between the CAD cases and controls(P> 0.05), even after adjusting for age, gender, body mass index, systolic blood pressure, diastolic blood pressure, glucose, total cholesterol, and triglyceride. However, when substratification analysis of the involved coronary artery vessels was performed, significant difference was found between single-vessel and triple-vessel (P= 0.02, OR = 1.56, 95% CI: 1.08-2.26) involvement.


CONCLUSIONS
The rs2298212G/A polymorphism in OX40 gene may be associated with the severity of coronary atherosclerotic disease.
Cheng
Guang-hui
GH
Institute of Medical Genetics and Key Laboratory for Experimental Teratology of the Ministry of Education, School of Medicine, Shandong University, Jinan, Shandong, P.R. China.
Wang
Hui
H
Ma
Long
L
Zhang
Kai
K
Li
Li
L
Gong
Yao-qin
YQ
Liu
Qi-ji
QJ
D044466:Asian People / Q000208:ethnology* / Q000235:genetics*; D001483:Base Sequence; D003324:Coronary Artery Disease / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D053262:Receptors, OX40 / Q000235:genetics*
D053262:Receptors, OX40; C505716:TNFRSF4 protein, human