[Effect of zishen shengxue recipe on endogenous erythropoietin in patients with renal anemia undergoing long-term hemodialysis].
OBJECTIVE
To investigate the mechanism of Zishen Shengxue Recipe (ZSR) in treating renal anemia by observing its effect on serum level of endogenous erythropoietin in patients undergoing long-term hemodialysis.


METHODS
Sixty renal anemia patients undergoing long-term hemodialysis were randomly and equally assigned to two groups. The treated group was treated with subcutaneous injection of erythropoiesis stimulating factor (rHuEpo) combined with oral intake of ZSR, and the control group treated with rHuEpo alone. They were observed for eight weeks, and the blood levels of endogenous human erythropoietin (Epo), hemoglobin (Hgb), hematocrit (Hct), as well as the residual renal function (RRF) in the two groups were compared.


RESULTS
Serum Epo level in the control group was unchanged after treatment (P>0.05), while that in the treated group increased significantly, and showed significant difference in comparing with that in the control group (P<0.05). Levels of Hgb and Hct increased and RRF decreased in both groups (P<0.01), but the treated group showed higher increments and lesser decrement than those in the control group (P<0.05).


CONCLUSIONS
ZSR can enhance the blood levels of Hgb, Hct and Epo, postpone the descent of RRF, and correct the anemic status in patients. Its mechanism of action is possibly through alleviating the inhibition of uremic toxin on erythropoiesis, in the meanwhile of promoting the secretion of Epo.
Tan
Jin-chuan
JC
Department of Renal Medicine, Chinese Medical Hospital of Hebei Medical University, Shijiazhuang 050011. TanJinChuan@medmail.com.cn
Hu
Jin-huan
JH
Su
Jing-wen
JW
D000328:Adult; D000740:Anemia / Q000097:blood* / Q000628:therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004920:Erythropoiesis / Q000187:drug effects; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006397:Hematinics / Q000627:therapeutic use; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D004365:Drugs, Chinese Herbal; D006397:Hematinics; D006454:Hemoglobins; D004921:Erythropoietin