A butenolide intermediate in methylenomycin furan biosynthesis is implied by incorporation of stereospecifically 13C-labelled glycerols.
The label from [3-(13)C]-L-glycerol is incorporated into the hydroxymethyl group of methylenomycin furans suggesting a butenolide intermediate in their biosynthesis.
Corre
Christophe
C
Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
Haynes
Stuart W
SW
Malet
Nicolas
N
Song
Lijiang
L
Challis
Gregory L
GL
D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002247:Carbon Isotopes / Q000378:metabolism; D005663:Furans / Q000378:metabolism*; D005990:Glycerol / Q000378:metabolism*; D013237:Stereoisomerism; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D002247:Carbon Isotopes; D005663:Furans; C004511:butenolide; D015107:4-Butyrolactone; D005990:Glycerol