Drugging drug resistance.
Resistance to anticancer drugs is widely observed in vitro and in cancer patients, but its prevalence is too high to be solely explained by the acquisition of mutations. Sharma et al. (2010) now report that dynamic chromatin modifications may be an independent route to drug resistance in cancer cells that can be reversed by epigenetic drugs.
Dannenberg
Jan-Hermen
JH
Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
Berns
Anton
A