Changes in renal function after nephron-sparing surgery in patients with a normal contralateral kidney.
OBJECTIVE
To evaluate the pattern of the recovery of the overall and isolated renal function in patients with a normal contralateral kidney undergoing nephron-sparing surgery (NSS).


METHODS
Between 2003 and 2006, 62 patients underwent open NSS at our institution. Among them, 35 having unilateral renal tumors smaller than 7 cm and a normally functioning contralateral kidney were included in the analysis. The estimated glomerular filtration rate (eGFR) was checked preoperatively, and 2 weeks, 6 months and 1 year postoperatively, and annually thereafter. Renal scintigraphy was carried out before the procedure, at 6 months and 1 year postoperatively to measure individual renal uptake.


RESULTS
eGFR was 80.9, 70.8, 76.7, 76.9, 75.8, 76.9, 78.6 and 78.2 mL/min/1.73 m(2) preoperatively, and postoperatively at 2 weeks, 6 months, 1, 2, 3, 4 and 5 years, respectively. Average isolated differential function of the operated kidney decreased 11.6% and 5.6% at 6 months and 1 year after surgery, respectively.


CONCLUSIONS
Within 6 months after NSS, the overall renal function recovered up to 95% by a compensatory increase of contralateral renal function. Thereafter, isolated function of the operated kidney recovered slowly.
Park
Sung-Woo
SW
Medical Research Institute, and Department of Urology, Pusan National University Yangsan Hospital, Yangsan, Korea.
Jung
Suk-Gun
SG
Lee
Wan
W
Chung
Moon-Kee
MK
D000328:Adult; D000368:Aged; D003080:Cold Temperature; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000502:physiology / Q000601:surgery*; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009399:Nephrons / Q000502:physiology / Q000601:surgery*; D011183:Postoperative Complications / Q000503:physiopathology / Q000517:prevention & control; D011877:Radionuclide Imaging; D020127:Recovery of Function / Q000502:physiology*; D015427:Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control; D012720:Severity of Illness Index; D055815:Young Adult