Effect of losartan on vascular function in fructose-fed rats: the role of perivascular adipose tissue.
Recent studies have shown the effect of perivascular adipose tissue (PVAT) on the regulation of vascular function; however, its role in the model of metabolic syndrome remains unclear. The aim of this study was to examine the effect of losartan on PVAT-derived vascular dysfunction in fructose-induced hypertensive rats. Rats were fed with either water, 10% fructose, or 10% fructose with 10mg/kg losartan for 8 weeks. In the isolated aorta with PVAT and endothelium, contraction induced by norepinephrine (NE) was more potent in fructose-fed rats compared to control rats. Losartan normalized blood pressure, insulin resistance, and NE-induced vasoconstriction in fructose-fed rats. In the aortic rings with/without endothelium and with/without PVAT, losartan could not improve the acetylcholine-induced relaxation in fructose-fed rats. The observation suggested that losartan partly improved the PVAT-associated vascular regulation in fructose-induced hypertensive rats.
Huang
Fengyang
F
Department of Pharmacology and Toxicology, Hospital Infantil de México Federico Gómez, México.
Lezama
Miguel Angel Rosas
MA
Ontiveros
José Alfredo Pérez
JA
Bravo
Guadalupe
G
Villafaña
Santiago
S
del-Rio-Navarro
Blanca Estela
BE
Hong
Enrique
E
D000109:Acetylcholine / Q000494:pharmacology; D000273:Adipose Tissue / Q000187:drug effects* / Q000503:physiopathology*; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000503:physiopathology*; D004195:Disease Models, Animal; D005632:Fructose / Q000633:toxicity; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D019808:Losartan / Q000494:pharmacology*; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000150:complications / Q000503:physiopathology; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
D047228:Angiotensin II Type 1 Receptor Blockers; D005632:Fructose; D019808:Losartan; D000109:Acetylcholine; D009638:Norepinephrine