[Localization of epileptic foci in frontal lobe epilepsy and its surgical therapy].
OBJECTIVE
To analyze the clinical data and pre-operative examination results of frontal lobe epilepsy and combine with intra-operative intracranial electrical record in order to localize epileptic foci and to direct surgical therapy.


METHODS
Preoperative EEG record and MRI scan were performed in 23 patients with refractory frontal lobe epilepsy. Among them, 17 patients received interictal 18F-FDG-PET-CT, 11 received MEG examination, 2 received functional MRI, 10 received surgical operation and intra-operative intracranial electrical record.


RESULTS
The positive predictive value of clinical features of epileptic seizure, interictal EEG, ictal EEG, MRI and PET-CT were 56.52%, 56.52%, 60.87%, 54.55% and 94.12% respectively. Their consistent results helped to confirm the epileptogenic zone. MEG was more accurate than EEG. ECoE and VEEG monitoring was significant for operative guidance.


CONCLUSIONS
A series of examinations is necessary for the diagnosis of epileptogenic zone of frontal lobe epilepsy. The surgical outcome is related to the accuracy of epileptic foci localization and the removal of epileptogenic zone.
Yu
Qing
Q
Department of Neurology, General Hospital of Tianjin Medical University, Tianjin 300052, China.
Yang
Wei-dong
WD
Wang
Zeng-guang
ZG
Gao
Shuo
S
Xue
Jing-yuan
JY
Chen
Zhi-juan
ZJ
Chen
Ying
Y
Wang
Feng-lou
FL
D000293:Adolescent; D000328:Adult; D002648:Child; D004569:Electroencephalography; D017034:Epilepsy, Frontal Lobe / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D014057:Tomography, X-Ray Computed; D055815:Young Adult