title: A phase II trial of docetaxel and ifosfamide for patients with platinum-resistant or refractory non-small cell lung cancer in a salvage setting.
abstract: OBJECTIVE
  We conducted a phase II study of docetaxel and ifosfamide chemotherapy for patients with platinum-resistant or refractory non-small-cell lung cancer (NSCLC) to evaluate the response and toxicity profiles as a salvage treatment.
  
  
  METHODS
  Between July 2000 and July 2004, 40 patients who had previously received platinum-based regimen as the first-line or second-line therapy were enrolled in this study. The treatment consisted of a docetaxel 75 mg/m(2) intravenous infusion on day 1 and intravenous ifosfamide 3 g/m(2) with Mesna uroprotectione on day 1 through 3. This regimen was repeated every 3 weeks.
  
  
  RESULTS
  One hundred thirty cycles of treatment were given, with a median of 3 cycles (range: 2 approximately 6 cycles). All the patients were evaluable for the response rate and toxicity profile. The major toxicity was myelosuppression. Grade 3 approximately 4 neutropenia occurred in 30 patients (75%) during treatment. Febrile neutropenia occurred in 16 patients (40%). Five of 40 patients (12.5%) had a partial response (95% confidence interval, 3.3 approximately 21.7%). The median time to disease progression was 2.65 months (range: 2.02 approximately 3.20 months), and the median survival was 5.24 months (range: 2.99 approximately 7.49 months).
  
  
  CONCLUSIONS
  Salvage chemotherapy with docetaxel and ifosfamide showed a low efficacy and a high proportion of severe neutropenia in patients with platinum-resistant or refractory advanced NSCLC.
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, College of Medicine, Gyeong-Sang National University, Jinju, Korea.
authors.forename: Gyeong-Won
authors.initials: GW
authors.lastname: Lee
authors.forename: Jung-Hun
authors.initials: JH
authors.lastname: Kang
authors.forename: Seok-Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Hea Yong
authors.initials: HY
authors.lastname: Lee
authors.forename: Ho-Cheol
authors.initials: HC
authors.lastname: Kim
authors.forename: Won-Sup
authors.initials: WS
authors.lastname: Lee
authors.forename: Jong-Duk
authors.initials: JD
authors.lastname: Lee
authors.forename: Young-Sil
authors.initials: YS
authors.lastname: Hwang
authors.forename: Joung-Soon
authors.initials: JS
authors.lastname: Jang
authors.forename: Jong-Seok
authors.initials: JS
authors.lastname: Lee