title: Kappa opioids and the modulation of pain.
abstract: OBJECTIVE
  Pain is a complex sensory experience, involving cognitive factors, environment (setting, society, and culture), experience, and gender and is modulated significantly by the central nervous system (CNS). The mechanisms by which opioid analgesics work are understood, but this class of drugs is not ideal as either an analgesic or anti-hyperalgesic. Accordingly, considerable effort continues to be directed at improved understanding of nociceptor function and development of selective analgesics that do not have the unwanted effects associated with opioid analgesics.
  
  
  OBJECTIVE
  The purpose of this paper is to provide a review of the role of KOP receptors in the modulation of pain and highlight several chemotypes currently being explored as peripherally restricted KOP ligands.
  
  
  RESULTS
  A growing body of literature has shown that KOP receptors are implicated in a variety of behavioral pain models. Several different classes of peripherally restricted peptidic and nonpeptidic KOP agonists have been identified and show utility in treating painful conditions.
  
  
  CONCLUSIONS
  The pharmacological profile of KOP agonists in visceral pain models suggest that peripherally restricted KOP agonists are potentially useful for a variety of peripheral pain states. Further, clinical investigation of peripherally restricted KOP agonists will help to clarify the painful conditions where KOP agonists will be most effective.
authors.affiliation: School of Biological Sciences, Victoria University of Wellington, P.O. Box 600, Wellington, New Zealand.
authors.forename: Bronwyn
authors.initials: B
authors.lastname: Kivell
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Prisinzano
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D008465:Mechanoreceptors / Q000502:physiology; D009619:Nociceptors / Q000502:physiology; D010146:Pain / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D017473:Receptors, Opioid, kappa / Q000819:agonists* / Q000037:antagonists & inhibitors / Q000502:physiology*; D017450:Receptors, Opioid, mu / Q000819:agonists
chemical_list: D000701:Analgesics, Opioid; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu