title: Whole-genome characterization and genotyping of global WU polyomavirus strains.
abstract: Exploration of the genetic diversity of WU polyomavirus (WUV) has been limited in terms of the specimen numbers and particularly the sizes of the genomic fragments analyzed. Using whole-genome sequencing of 48 WUV strains collected in four continents over a 5-year period and 16 publicly available whole-genome sequences, we identified three main WUV clades and five subtypes, provisionally termed Ia, Ib, Ic, II, IIIa, and IIIb. Overall nucleotide variation was low (0 to 1.2%). The discriminatory power of the previous VP2 fragment typing method was found to be limited, and a new, larger genotyping region within the VP2/1 interface was proposed.
authors.affiliation: Sir Albert Sakzewski Virus Research Centre, Building C28, Back Rd., Herston, Queensland 4029, Australia. seweryn@uq.edu.au
authors.forename: Seweryn
authors.initials: S
authors.lastname: Bialasiewicz
authors.forename: Rebecca
authors.initials: R
authors.lastname: Rockett
authors.forename: David W
authors.initials: DW
authors.lastname: Whiley
authors.forename: Yacine
authors.initials: Y
authors.lastname: Abed
authors.forename: Tobias
authors.initials: T
authors.lastname: Allander
authors.forename: Michael
authors.initials: M
authors.lastname: Binks
authors.forename: Guy
authors.initials: G
authors.lastname: Boivin
authors.forename: Allen C
authors.initials: AC
authors.lastname: Cheng
authors.forename: Ju-Young
authors.initials: JY
authors.lastname: Chung
authors.forename: Patricia E
authors.initials: PE
authors.lastname: Ferguson
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Gilroy
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Leach
authors.forename: Cecilia
authors.initials: C
authors.lastname: Lindau
authors.forename: John W
authors.initials: JW
authors.lastname: Rossen
authors.forename: Tania C
authors.initials: TC
authors.lastname: Sorrell
authors.forename: Michael D
authors.initials: MD
authors.lastname: Nissen
authors.forename: Theo P
authors.initials: TP
authors.lastname: Sloots
mesh_terms: D001483:Base Sequence; D014644:Genetic Variation; D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D011120:Polyomavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D027601:Polyomavirus Infections / Q000821:virology*