Vitamin E-coated cellulose acetate dialysis membrane: long-term effect on inflammation and oxidative stress.
BACKGROUND
Chronic inflammation and oxidative stress are prevalent in hemodialysis (HD) patients. We evaluated the long-term effect of a vitamin E-coated cellulose acetate (CAE) membrane on oxidative stress and inflammation.


METHODS
Nine patients were switched to CAE membrane for 3 months and then changed back to polysulfone (PS) membrane again for 6 months. Reactive oxygen metabolites and derivatives (d-ROMs), total antioxidant capacity (TAC) and superoxide dismutase (SOD) (oxidative stress biomarkers), high-sensitivity C-reactive protein (Hs-CRP), and interleukin-6 (IL-6) (inflammation biomarkers) were measured.


RESULTS
d-ROMs decreased and TAC rose significantly at the end of the study, whereas SOD increased rapidly and immediately after the end of CAE treatment. Hs-CRP and IL-6 levels were significantly lowered at the end of the study.


CONCLUSIONS
Vitamin E supplementation by vitamin E-coated CAE dialysis membrane suppresses oxidative stress and inflammation.
Takouli
L
L
Nephrology Department, Amalia Fleming Hospital, Athens, Greece. ltakouli@yahoo.gr
Hadjiyannakos
D
D
Metaxaki
P
P
Sideris
V
V
Filiopoulos
V
V
Anogiati
A
A
Vlassopoulos
D
D
D000368:Aged; D000975:Antioxidants / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis; D002482:Cellulose / Q000031:analogs & derivatives*; D020099:Coated Materials, Biocompatible; D005260:Female; D005609:Free Radicals / Q000032:analysis; D006801:Humans; D007249:Inflammation; D015850:Interleukin-6 / Q000097:blood; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D018384:Oxidative Stress; D011108:Polymers; D017382:Reactive Oxygen Species / Q000097:blood; D006435:Renal Dialysis / Q000295:instrumentation*; D013450:Sulfones; D013482:Superoxide Dismutase / Q000097:blood; D014810:Vitamin E
D000975:Antioxidants; D020099:Coated Materials, Biocompatible; D005609:Free Radicals; D015850:Interleukin-6; D008567:Membranes, Artificial; D011108:Polymers; D017382:Reactive Oxygen Species; D013450:Sulfones; D014810:Vitamin E; C017662:polysulfone P 1700; C005062:acetylcellulose; D002482:Cellulose; D002097:C-Reactive Protein; D013482:Superoxide Dismutase