title: Further pharmacological and genetic evidence for the efficacy of PlGF inhibition in cancer and eye disease.
abstract: Our findings that PlGF is a cancer target and anti-PlGF is useful for anticancer treatment have been challenged by Bais et al. Here we take advantage of carcinogen-induced and transgenic tumor models as well as ocular neovascularization to report further evidence in support of our original findings of PlGF as a promising target for anticancer therapies. We present evidence for the efficacy of additional anti-PlGF antibodies and their ability to phenocopy genetic deficiency or silencing of PlGF in cancer and ocular disease but also show that not all anti-PlGF antibodies are effective. We also provide additional evidence for the specificity of our anti-PlGF antibody and experiments to suggest that anti-PlGF treatment will not be effective for all tumors and why. Further, we show that PlGF blockage inhibits vessel abnormalization rather than density in certain tumors while enhancing VEGF-targeted inhibition in ocular disease. Our findings warrant further testing of anti-PlGF therapies.
authors.affiliation: Vesalius Research Center, KU Leuven, Leuven B-3000, Belgium.
authors.forename: Sara
authors.initials: S
authors.lastname: Van de Veire
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Stalmans
authors.forename: Femke
authors.initials: F
authors.lastname: Heindryckx
authors.forename: Hajimu
authors.initials: H
authors.lastname: Oura
authors.forename: Annemilaï
authors.initials: A
authors.lastname: Tijeras-Raballand
authors.forename: Thomas
authors.initials: T
authors.lastname: Schmidt
authors.forename: Sonja
authors.initials: S
authors.lastname: Loges
authors.forename: Imke
authors.initials: I
authors.lastname: Albrecht
authors.forename: Bart
authors.initials: B
authors.lastname: Jonckx
authors.forename: Stefan
authors.initials: S
authors.lastname: Vinckier
authors.forename: Christophe
authors.initials: C
authors.lastname: Van Steenkiste
authors.forename: Sònia
authors.initials: S
authors.lastname: Tugues
authors.forename: Charlotte
authors.initials: C
authors.lastname: Rolny
authors.forename: Maria
authors.initials: M
authors.lastname: De Mol
authors.forename: Daniela
authors.initials: D
authors.lastname: Dettori
authors.forename: Patricia
authors.initials: P
authors.lastname: Hainaud
authors.forename: Lieve
authors.initials: L
authors.lastname: Coenegrachts
authors.forename: Jean-Olivier
authors.initials: JO
authors.lastname: Contreres
authors.forename: Tine
authors.initials: T
authors.lastname: Van Bergen
authors.forename: Henar
authors.initials: H
authors.lastname: Cuervo
authors.forename: Wei-Hong
authors.initials: WH
authors.lastname: Xiao
authors.forename: Carole
authors.initials: C
authors.lastname: Le Henaff
authors.forename: Ian
authors.initials: I
authors.lastname: Buysschaert
authors.forename: Behzad
authors.initials: B
authors.lastname: Kharabi Masouleh
authors.forename: Anja
authors.initials: A
authors.lastname: Geerts
authors.forename: Tibor
authors.initials: T
authors.lastname: Schomber
authors.forename: Philippe
authors.initials: P
authors.lastname: Bonnin
authors.forename: Vincent
authors.initials: V
authors.lastname: Lambert
authors.forename: Jurgen
authors.initials: J
authors.lastname: Haustraete
authors.forename: Serena
authors.initials: S
authors.lastname: Zacchigna
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Rakic
authors.forename: Wladimiro
authors.initials: W
authors.lastname: Jiménez
authors.forename: Agnes
authors.initials: A
authors.lastname: Noël
authors.forename: Mauro
authors.initials: M
authors.lastname: Giacca
authors.forename: Isabelle
authors.initials: I
authors.lastname: Colle
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Foidart
authors.forename: Gerard
authors.initials: G
authors.lastname: Tobelem
authors.forename: Manuel
authors.initials: M
authors.lastname: Morales-Ruiz
authors.forename: José
authors.initials: J
authors.lastname: Vilar
authors.forename: Patrick
authors.initials: P
authors.lastname: Maxwell
authors.forename: Stanley A
authors.initials: SA
authors.lastname: Vinores
authors.forename: Geert
authors.initials: G
authors.lastname: Carmeliet
authors.forename: Mieke
authors.initials: M
authors.lastname: Dewerchin
authors.forename: Lena
authors.initials: L
authors.lastname: Claesson-Welsh
authors.forename: Evelyne
authors.initials: E
authors.lastname: Dupuy
authors.forename: Hans
authors.initials: H
authors.lastname: Van Vlierberghe
authors.forename: Gerhard
authors.initials: G
authors.lastname: Christofori
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Mazzone
authors.forename: Michael
authors.initials: M
authors.lastname: Detmar
authors.forename: Désiré
authors.initials: D
authors.lastname: Collen
authors.forename: Peter
authors.initials: P
authors.lastname: Carmeliet
mesh_terms: D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000517:prevention & control; D002829:Choroid / Q000098:blood supply; D004195:Disease Models, Animal; D005128:Eye Diseases / Q000473:pathology; D006801:Humans; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D010212:Papilloma / Q000098:blood supply / Q000139:chemically induced / Q000517:prevention & control; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism*; D012878:Skin Neoplasms / Q000098:blood supply / Q000139:chemically induced / Q000517:prevention & control
chemical_list: D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; C000608036:PGF protein, human; C000608037:Pgf protein, mouse; D011257:Pregnancy Proteins; D000072483:Placenta Growth Factor