Polysialic acid affects pathophysiological consequences of status epilepticus.
Modulation of the neural cell adhesion molecule by the attachment of polysialic acid residues through the polysialyl-transferase, ST8SiaIV, regulates neuronal plasticity and affects cellular alterations in the epileptic brain. Here, we determined the impact of ST8SiaIV deficiency on the pathophysiological consequences of status epilepticus (SE). ST8SiaIV deficiency reduced the latency to SE induction and increased SE-mediated mortality. Analysis of the doublecortin expression showed a reduced number of neuroblasts as a long-term consequence of SE in ST8SiaIV knockouts. Testing in a battery of different behavioral paradigms indicated that loss of ST8SiaIV affects the long-term behavioral consequences. In summary, the data suggest that the polysialic acid-neural cell adhesion molecule system is a putative target for the modulation of pathophysiological events and affects psychiatric comorbidities in epilepsies.
Pekcec
Anton
A
Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig-Maximilians-University, Munich, Germany.
Weinhold
Birgit
B
Gerardy-Schahn
Rita
R
Potschka
Heidrun
H
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D018891:Dentate Gyrus / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D005106:Exploratory Behavior / Q000502:physiology; D018782:Maze Learning / Q000502:physiology; D008569:Memory Disorders / Q000201:enzymology / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D009026:Mortality; D009043:Motor Activity / Q000502:physiology; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism; D055495:Neurogenesis / Q000235:genetics; D009474:Neurons / Q000201:enzymology; D012799:Sialyltransferases / Q000235:genetics*; D013226:Status Epilepticus / Q000201:enzymology* / Q000235:genetics* / Q000503:physiopathology; D013234:Stem Cells / Q000201:enzymology; D013997:Time Factors
D019006:Neural Cell Adhesion Molecules; D012799:Sialyltransferases; C525848:ST8SiaIV protein, mouse