Pup grows up: in vitro characterization of the degradation of pupylated proteins.
By reconstituting the recently discovered prokaryotic ubiquitin-like protein (Pup)--proteasome degradation system in vitro, Weber-Ban and colleagues (Striebel et al, 2010) elucidate its mechanism and describe a surprising variation on the established principles of protease targeting. Nevertheless, their findings suggest that the bacterial and eukaryotic systems follow the same overall principles even if the details differ.
Kraut
Daniel A
DA
Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL, USA. matouschek@northwestern.edu
Matouschek
Andreas
A
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D014452:Ubiquitins / Q000378:metabolism*
D001426:Bacterial Proteins; D014452:Ubiquitins; D046988:Proteasome Endopeptidase Complex; D000251:Adenosine Triphosphatases; C479920:Mpa protein, Mycobacterium tuberculosis