Pediatric kidney transplantation.
Kidney transplantation in pediatric patients has become a routinely successful procedure, with 1- and 5-year patient survival rates of 98% and 94%, and 1- and 5-year graft survival rates of 93% to 95% and 77% to 85% (the range takes into account differences between living and deceased donors). These good outcomes represent the cumulative effect of improvements in pre- and posttransplant patient care, operative techniques, immunosuppression, and infection prophylaxis, diagnosis, and treatment. This article provides a brief historical overview, discusses the indications for transplantation, describes the evaluation process for the recipient and the potential donor, outlines the operative details, reviews the various causes of and risk factors for graft dysfunction, and analyzes outcomes.
Shapiro
Ron
R
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA. shapiror@upmc.edu
Sarwal
Minnie M
MM
D002648:Child; D049673:History, 20th Century; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects / Q000266:history / Q000379:methods / Q000639:trends; D018579:Patient Selection; D012106:Research; D012307:Risk Factors; D014181:Transplantation Immunology; D016896:Treatment Outcome