title: Primary adenomyoepithelioma of tonsil.
abstract: We present a case of adenomyoepithlioma (AME) arising from the tonsil. AME is an uncommon tumor that typically arises in breast, but rarely found in salivary glands, lung, and skin. Its biological features have not been thoroughly characterized. Here we describe a primary AME originating from the tonsil. The pathologic changes were characterized by hypercellularity, the dominance of both epithelial and myoepithelial cells. Malignancy was evidenced by the presence of a high mitotic rate and invasive growth. The epithelial cells express high levels of cytokeratin and epithelial membrane antigen (EMA). The myoepithelial cells show positive staining for calponin, p63, vimentin, and S-100. A thorough review of the literature indicates that this is likely the first reported case of AME from the tonsil. Following descriptions of the diagnosis, treatment, and prognosis of this specific case, pathologic and clinical characteristics of AME from other tissues are also compiled and discussed.
authors.affiliation: Cancer center, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Ren
authors.affiliation: Cancer center, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
authors.forename: Liping
authors.initials: L
authors.lastname: Song
authors.affiliation: Medical school of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, PR China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Dang
authors.affiliation: Cancer center, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
authors.forename: Xiaozhi
authors.initials: X
authors.lastname: Zhang
authors.affiliation: Department of Basic Biomedical Sciences, Mercer University School of Medicine, GA 31404, USA.|Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Shi-Wen
authors.initials: SW
authors.lastname: Jiang
authors.affiliation: Cancer center, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
authors.forename: Guanjun
authors.initials: G
authors.lastname: Zhang
authors.affiliation: Medical school of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, PR China.
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.affiliation: Cancer center, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
authors.forename: Zi
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Cancer center, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Internal Medicine, Mayo Clinic, MN, 55905, USA.
authors.forename: Yi Lisa
authors.initials: YL
authors.lastname: Hwa
authors.affiliation: Second Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
authors.forename: Zongfang
authors.initials: Z
authors.lastname: Li
authors.affiliation: Cancer center, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
authors.forename: Xinhan
authors.initials: X
authors.lastname: Zhao
authors.affiliation: Department of pathology, Dental Hospital, Fourth Military Medical University, 710038 PR China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Liu
mesh_terms: D055331:Adenomyoepithelioma / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D014067:Tonsillar Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy