Consumption of curcumin elevates fecal immunoglobulin A, an index of intestinal immune function, in rats fed a high-fat diet.
This study was conducted to elucidate the effects of dietary polyphenols on intestinal immunoglobulin A (IgA) response and mucin levels in rats fed a high-fat diet. In experiment 1, rats were fed a high-fat diet with or without several polyphenols including curcumin, rutin, D(+)-catechin, ellagic acid and quercetin at the level of 0.5%. Among the polyphenols examined, consumption of curcumin markedly elevated the level of IgA in feces and colon contents. In experiment 2, rats were fed a high-fat diet or a low-fat diet with or without 0.5% curcumin. Fecal level of IgA was higher in the high-fat diet group than in the low-fat diet group. In the rats fed the high-fat diet, dietary curcumin elevated fecal IgA, but not in those fed the low-fat diet. These results imply a novel effect of curcumin on intestinal IgA in animals fed a high-fat diet.
Okazaki
Yukako
Y
Faculty of Human Life Sciences, Fuji Women's University, Ishikari, Japan. yokazaki@fujijoshi.ac.jp
Han
Yunkyung
Y
Kayahara
Mai
M
Watanabe
Toshiro
T
Arishige
Hirofumi
H
Kato
Norihisa
N
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D003106:Colon / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D030024:Curcuma / Q000737:chemistry; D003474:Curcumin / Q000494:pharmacology*; D004041:Dietary Fats / Q000008:administration & dosage*; D005243:Feces / Q000737:chemistry; D005419:Flavonoids / Q000494:pharmacology; D007070:Immunoglobulin A / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism*; D008297:Male; D009077:Mucins / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D059808:Polyphenols; D051381:Rats; D017207:Rats, Sprague-Dawley
D000276:Adjuvants, Immunologic; D004041:Dietary Fats; D005419:Flavonoids; D007070:Immunoglobulin A; D009077:Mucins; D010636:Phenols; D010936:Plant Extracts; D059808:Polyphenols; D003474:Curcumin