[Morpho-functional changes in the goldfish Mauthner neurons after beta-amyloid application].
The influence of aggregated beta-amyloid peptide fragment 25-35 application on three-dimensional structure and volume of Mauthner cells (MCs), as determined by reconstruction from serial histological sections, and on goldfish motor asymmetry was studied. It was shown that in intact and control goldfish motor asymmetry was stable and strongly correlated with structural asymmetry of neurons. But under the influence of beta-amyloid, motor asymmetry appeared to be strongly changed or inverted, did not correlate with structural asymmetry and frequently even was opposite to it. This resulted from strong dystrophy or, on the contrary, hypertrophy of individual neurons and their separate dendrites with the change in the proportions between them. It is suggested that injurious effect of beta-amyloid peptide on MCs structure, discordant with ("irregular") fish behavior, could be the result of mechanical deformation, induced by ribbon-like fibrils of amyloid peptide. These findings collectively suggest that MCs are the adequate object for the study of the structural aspects of amyloidosis.
Kokanova
N A
NA
Mikhaĭlova
G Z
GZ
Shtanchaev
R Sh
RSh
Tiras
N R
NR
Bezgina
E N
EN
Moshkov
D A
DA
D016229:Amyloid beta-Peptides / Q000502:physiology / Q000633:toxicity*; D000818:Animals; D007839:Functional Laterality; D006054:Goldfish; D009046:Motor Neurons / Q000187:drug effects* / Q000473:pathology; D009068:Movement / Q000187:drug effects*; D010446:Peptide Fragments / Q000502:physiology / Q000633:toxicity*
D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C074636:amyloid beta-protein (25-35)