[Report of 2 cases of novel influenza A (H1N1) virus infection complicated with pneumonia and hypoxemia].
OBJECTIVE
to improve understanding of the novel influenza A (H1N1) virus infection complicated with pneumonia.


METHODS
clinical presentations, radiological data, laboratory data and treatments of 2 patients with pneumonia caused by the novel influenza A (H1N1) virus were retrospectively analyzed.


RESULTS
one patient was a middle-aged woman, and the other was a young man with a history of asthma. Both patients had fever (temperatures more than 39 degrees C), cough, and dyspnea. At the time of admission, both patients had hypoxemia. Chest computed tomography (CT) scan showed patchy distribution of consolidation and ground-glass opacity mainly in peripheral subpleural regions, as well as peribrochovascular lesions with air-bronchogram. The decreased and lymphocytes, elevated lactate dehydrogenase and creatine kinase were found in both patients. After admission, the patients received oseltamivir with a dose of 75 mg twice a day for a minimum of 5 days. Other treatments included antibiotics and methylprednisolone. One patient needed intermittent non-invasive ventilation for respiratory distress. Both patients recovered and the opacities on their chest CT were almost absorbed. WBC counts increased to normal and the levels of LDH and CK decreased.


CONCLUSIONS
patients with the novel influenza A (H1N1) virus infection may develop pneumonia. The manifestations are non-specific. Chest CT scan reveals patchy distribution of consolidation and ground-glass opacity. In addition to antiviral therapy, glucocorticoids may have some effects on the pulmonary lesions and be useful for improving the clinical conditions.
Dai
Jing-Hong
JH
Department of Respiratory Medicine, the Affiliated Gulou Hospital of Nanjing University, Nanjing 210008, China.
Cai
Hou-Rong
HR
Yang
Yong-Feng
YF
Teng
Chang-Qing
CQ
D000328:Adult; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000150:complications / Q000000981:diagnostic imaging / Q000821:virology*; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000150:complications* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000150:complications / Q000000981:diagnostic imaging / Q000821:virology*; D011859:Radiography; D012189:Retrospective Studies