Pallidal index measured with three-dimensional T1-weighted gradient echo sequence is a good predictor of manganese exposure in welders.
OBJECTIVE
To evaluate which T1-wieghted technique between 3D gradient-echo (FSPGR) and conventional spin-echo (SE) sequence is more sensitive predictor of neurobehavioral dysfunction found in welders with chronic manganese (Mn) acquired at 3 Tesla.


METHODS
Forty-three current male welders and 29 age- and gender-matched, nonwelding production workers (control individuals) were recruited to the present study. Each subject underwent neurological examination, blood sample collection, and neurobehavioral tests, in addition to magnetic resonance imaging (MRI) examination. The MRI examinations were performed using a 3.0 Tesla whole-body scanner. T1-weighted axial images were obtained using SE and FSPGR with a 180 degrees inversion recovery prepared pulse, and the corresponding pallidal indices (PI), PI (SE), and PI (FSPGR), were calculated.


RESULTS
Both PI (SE) and PI (FSPGR) were well correlated with blood Mn level, but only PI (FSPGR) was significantly correlated with air Mn concentration (P = 0.007). Of the neurobehavioral performance indicators, after controlling for covariates, PI (FSPGR) was significantly associated with cognitive components, such as the digit symbol score, the digit span backward score, the Stroop test score and also with the grooved pegboard (dominant hand) score, whereas PI (SE) was associated only with grooved pegboard (dominant hand) score.


CONCLUSIONS
PI using a T1-weighted 3D FSPGR sequence shows the best correlation with neurobehavioral performance indicators and is the best measure for detection of blood and airborne Mn concentrations in welders exposed to excessive occupational Mn.
Chang
Yongmin
Y
Department of Molecular Medicine, Kyungpook National University College of Medicine, Kyungpook National University Hospital, Daegu, South Korea.
Woo
Seung-Tae
ST
Kim
Yangho
Y
Lee
Jae-Jun
JJ
Song
Hui-Jin
HJ
Lee
Hui Joong
HJ
Kim
Suk Hwan
SH
Lee
Hun
H
Kwon
Young Joo
YJ
Ahn
Joon-Ho
JH
Park
Sin-Jae
SJ
Chung
In-Sung
IS
Jeong
Kyoung Sook
KS
D000328:Adult; D001519:Behavior / Q000187:drug effects; D001921:Brain / Q000473:pathology; D016022:Case-Control Studies; D003071:Cognition / Q000187:drug effects; D017352:Echo-Planar Imaging / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008345:Manganese / Q000633:toxicity*; D009422:Nervous System Diseases / Q000139:chemically induced; D016273:Occupational Exposure; D052638:Particulate Matter; D012044:Regression Analysis; D014896:Welding
D052638:Particulate Matter; D008345:Manganese