Paradoxical reaction to treatment in 2 patients with severe acute paracoccidioidomycosis: a previously unreported complication and its management with corticosteroids.
Paradoxical reactions have never been described in patients with paracoccidioidomycosis or other deep endemic mycoses out of the context of human immunodeficiency virus infection. We describe 2 patients with an acute form of paracoccidioidomycosis who presented with a worsening of their clinical manifestations while on appropriate antifungal treatment. These manifestations were severe and required adjunct corticosteroid therapy.
Gryschek
Ronaldo C B
RC
Division of Infectious Diseases, University of São Paulo, São Paulo, Brazil.
Pereira
Ricardo M
RM
Kono
Adriana
A
Patzina
Rosely A
RA
Tresoldi
Antonia T
AT
Shikanai-Yasuda
Maria A
MA
Benard
Gil
G
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D002648:Child; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007155:Immunologic Factors / Q000627:therapeutic use*; D008198:Lymph Nodes / Q000473:pathology; D008230:Lymphomatoid Granulomatosis / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008853:Microscopy; D009333:Neck / Q000473:pathology; D010229:Paracoccidioidomycosis / Q000150:complications* / Q000188:drug therapy*; D012867:Skin / Q000473:pathology
D000305:Adrenal Cortex Hormones; D000935:Antifungal Agents; D007155:Immunologic Factors