title: Synthesis, structures, and urease inhibitory activities of three copper(II) and zinc(II) complexes with 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol.
abstract: In order to explore novel urease inhibitors, three new mononuclear complexes of Cu(II) and Zn(II) with Schiff base 2-{[2-(2-hydroxyethylamino)ethylimino]methyl}-4-nitrophenol have been prepared and structurally characterized by X-ray crystallography. Among the three complexes, two Cu(II) complexes show strong urease inhibitory activities with the IC(50) values being much lower than that of the acetohydroxamic acid, while the Zn(II) complex shows no activity at the concentration of 100 microM.
authors.affiliation: Department of Chemistry and Chemical Engineering, Liaoning Normal University, Huanghe Road 850, Dalian 116029, PR China. youzhonglu@yahoo.com.cn
authors.forename: Zhong-Lu
authors.initials: ZL
authors.lastname: You
authors.forename: Li-Li
authors.initials: LL
authors.lastname: Ni
authors.forename: Da-Hua
authors.initials: DH
authors.lastname: Shi
authors.forename: Shun
authors.initials: S
authors.lastname: Bai
mesh_terms: D003300:Copper / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D007887:Fabaceae / Q000201:enzymology; D009596:Nitrophenols / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014510:Urease / Q000037:antagonists & inhibitors*; D015032:Zinc / Q000737:chemistry*
chemical_list: C551372:2-((2-(2-hydroxyethylamino)ethylimino)methyl)-4-nitrophenol; D004791:Enzyme Inhibitors; D009596:Nitrophenols; D009942:Organometallic Compounds; D003300:Copper; D014510:Urease; D015032:Zinc