title: Superstatistics analysis of the ion current distribution function: Met3PbCl influence study.
abstract: A novel analysis of ion current time series is proposed. It is shown that higher (second, third and fourth) statistical moments of the ion current probability distribution function (PDF) can yield new information about ion channel properties. The method is illustrated on a two-state model where the PDF of the compound states are given by normal distributions. The proposed method was applied to the analysis of the SV cation channels of vacuolar membrane of Beta vulgaris and the influence of trimethyllead chloride (Met(3)PbCl) on the ion current probability distribution. Ion currents were measured by patch-clamp technique. It was shown that Met(3)PbCl influences the variance of the open-state ion current but does not alter the PDF of the closed-state ion current. Incorporation of higher statistical moments into the standard investigation of ion channel properties is proposed.
authors.affiliation: Departments of Physics and Biophysics, Wrocław University of Environmental and Life Sciences, Wrocław, Poland. janusz.miskiewicz@up.wroc.pl
authors.forename: Janusz
authors.initials: J
authors.lastname: Miśkiewicz
authors.forename: Zenon
authors.initials: Z
authors.lastname: Trela
authors.forename: Stanisław
authors.initials: S
authors.lastname: Przestalski
authors.forename: Waldemar
authors.initials: W
authors.lastname: Karcz
mesh_terms: D007473:Ion Channels / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D007854:Lead / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D015233:Models, Statistical; D008962:Models, Theoretical; D009942:Organometallic Compounds / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D018408:Patch-Clamp Techniques; D011336:Probability; D013756:Tetraethyl Lead / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry / Q000378:metabolism
chemical_list: D007473:Ion Channels; D009942:Organometallic Compounds; D013756:Tetraethyl Lead; D007854:Lead; C029891:lead chloride; C039474:trimethyllead