title: Total synthesis of (+)-stachyflin: a potential anti-influenza A virus agent.
abstract: The first enantioselective total synthesis of (+)-stachyflin, a potential anti-influenza A virus agent, was achieved; the method features a BF(3).Et(2)O-induced domino epoxide-opening/rearrangement/cyclization reaction to stereoselectively form the requisite pentacyclic ring system in one step.
authors.affiliation: Laboratory of Synthetic Medicinal Chemistry, Department of Chemical Pharmaceutical Science, Tohoku Pharmaceutical University, 4-4-1 Komatsushima, 981-8558, Aoba-ku, Sendai, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Junji
authors.initials: J
authors.lastname: Sakurai
authors.forename: Hideki
authors.initials: H
authors.lastname: Abe
authors.forename: Tadashi
authors.initials: T
authors.lastname: Katoh
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis*; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D007251:Influenza, Human / Q000188:drug therapy; D012717:Sesquiterpenes / Q000138:chemical synthesis*; D013191:Stachybotrys / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000998:Antiviral Agents; D012717:Sesquiterpenes; C120519:stachyflin