Transcription factor Ets-1 in cytokine and chemokine gene regulation.
Ets-1 is a transcription factor that is highly expressed within lymphoid cells, where it is known to control their differentiation, survival and proliferation. Ets-1 is also expressed in other cell types and can be further induced by a variety of stimuli. Accumulating evidence points to an important role for Ets-1 in regulating the differentiation of T helper cell subsets, cytotoxic T cells, B cells and other cell types. Ets-1 also directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. In this review, we summarize the known roles for Ets-1 in regulating the differentiation of immune cells and other cell types. Furthermore, we review in detail the current understanding of Ets-1 regulation of cytokine and chemokine expression and how this may relate to the biological roles of Ets-1 in regulating immunity as well as in cancer progression.
Russell
Lisa
L
Department of Biochemistry, Developmental Genetics Focus Group, Center of Excellence in Bioinformatics and Life Sciences, State University of New York at Buffalo, Buffalo, NY 14203, USA.
Garrett-Sinha
Lee Ann
LA
D000818:Animals; D018925:Chemokines / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007107:Immune System / Q000378:metabolism; D050784:Proto-Oncogene Protein c-ets-1 / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics; D013601:T-Lymphocytes / Q000378:metabolism
D018925:Chemokines; D050784:Proto-Oncogene Protein c-ets-1