title: Early detection of amyloid aggregation using intrinsic fluorescence.
abstract: Beta-amyloid (Abeta) aggregation, believed to be responsible for Alzheimer's disease, is monitored using its intrinsic fluorescence decay. Alterations in the fluorescence decay of tyrosine correlate with the Abeta aggregation at a much earlier stage than the traditionally used fluorescence intensity of Thioflavin T (ThT). Potentially the finding may underpin progress towards an earlier diagnosis of the onset of Alzheimer's disease and an improved approach to developing intervention therapies.
authors.affiliation: Photophysics Group, Centre for Molecular Nanometrology, Department of Physics, Scottish Universities Physics Alliance, University of Strathclyde, 107 Rottenrow, Glasgow G4 0NG, UK. o.j.rolinski@strath.ac.uk
authors.forename: Olaf J
authors.initials: OJ
authors.lastname: Rolinski
authors.forename: Mariana
authors.initials: M
authors.lastname: Amaro
authors.forename: David J S
authors.initials: DJ
authors.lastname: Birch
mesh_terms: D016229:Amyloid beta-Peptides / Q000032:analysis* / Q000737:chemistry*; D046912:Multiprotein Complexes / Q000032:analysis / Q000737:chemistry; D010446:Peptide Fragments / Q000032:analysis* / Q000737:chemistry*; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D014443:Tyrosine / Q000737:chemistry*
chemical_list: D016229:Amyloid beta-Peptides; D046912:Multiprotein Complexes; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); D014443:Tyrosine