Parkinson disease: a role for autophagy?
Autophagy is a term used to describe the process by which lysosomes degrade intracellular components. Known originally as an adaptive response to nutrient deprivation, autophagy has now been recognized to play important roles in several human disorders including neurodegenerative diseases. Experimental results from genetic, cellular, and toxicological studies indicate that many of the etiological factors associated with Parkinson disease (PD) can perturb the autophagic process in various model systems. Thus, the emerging data support the view that dysregulation of autophagy may play a critical role in the pathogenic process of PD.
Yang
Qian
Q
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322-3090, USA.
Mao
Zixu
Z
D001343:Autophagy / Q000502:physiology*; D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008954:Models, Biological; D010300:Parkinson Disease / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology