title: The BARI 2D study: a randomised trial of therapies for type 2 diabetes and coronary artery disease.
abstract: The Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial randomized 2368 patients with type 2 diabetes (T2DM) and coronary artery disease to either prompt revascularization or intensive medical therapy alone; and to either insulin-sensitization or insulin-provision diabetes therapy. Randomization was stratified by proposed revascularization method. Five-year survival and major cardiovascular events (MACE) were similar in study subgroups except in the coronary bypass surgery (CABG) stratum where there were fewer MACE after revascularization. There was less hypoglycaemia and weight gain, and greater apparent benefit from CABG in the insulin sensitization group. BARI 2D has provided important data for clinicians.
authors.affiliation: Cardiovascular Research Group, School of Clinical and Laboratory Sciences, University of Manchester, Manchester, UK. martin.rutter@manchester.ac.uk
authors.forename: Martin K
authors.initials: MK
authors.lastname: Rutter
authors.forename: Richard W
authors.initials: RW
authors.lastname: Nesto
mesh_terms: D003324:Coronary Artery Disease / Q000401:mortality / Q000628:therapy*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use; D008687:Metformin / Q000627:therapeutic use; D009204:Myocardial Revascularization; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D045162:Thiazolidinediones / Q000627:therapeutic use
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D045162:Thiazolidinediones; D008687:Metformin