[Optimization of cataplasm matrix with face-centered design-response surface method].
OBJECTIVE
To optimize the matrix formulation of cataplasm.


METHODS
Face-centered design was used in the experimental design, and response surface was produced in quadratic polynomial after data fitting in order to explore the impacts of Sodium Polyacrylate, Carbomer and the cross-linking agent on stickiness of cataplasm, optimize the prescription of the cataplasm matrix and perform the evaluation analysis.


RESULTS
The multiple correlation coefficient (R2) and adjusted R2 in the fitting method using quadratic polynomial were 0.970 and 0. 952 (F = 53.953, P = 0.0001), respectively, and the model was significant different. The ratio of optimum proportion of Sodium Polyacrylate, Carbomer and the cross-linking agent in the matrix of cataplasm was determined, which was proved efficaciously.


CONCLUSIONS
Face-centered design-response surface method is a simple method with good prediction result for the optimization of cataplasm matrix.
Liu
Shuzhi
S
Institute of Chinese Materia Medical, China Academy of Chinese Medical Sciences, Beijing 100700, China. liushuzhi2004@sina.com
Li
Junhong
J
Jin
Rixian
R
Du
Maobo
M
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008962:Models, Theoretical
D004365:Drugs, Chinese Herbal