A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients.
Sustained attention as measured by the Continuous Performance Test (CPT) has proved a valuable endophenotype for schizophrenia. Recently pharmacological studies suggested a role of the serotonin (5-HT) 3 receptor in schizophrenia. The 5-HT3 receptors are the only ligand-gated ion channels within the 5-HT receptor family. Applying an endophenotype approach, we investigated a potential impact of the genes of the 5-HT3A and 5-HT3B subunits as well as the novel 5-HT3C, 5-HT3D, and 5-HT3E subunits on CPT performance in subjects with schizophrenia. The study included 196 patients with schizophrenia, 113 of their parents, and 205 healthy controls recruited from community registers. Sustained attention was assessed with the Continuous Performance Test-Identical Pairs (CPT-IP). Assessing functional and coding variants of the 5-HT3 receptor subunit genes, we found the GG genotype of the 5-HT3E subunit gene (rs7627615; Thr86Ala) to be associated with better attentional capacities in subjects with schizophrenia and healthy controls. This study provides additional evidence for a role of the serotonergic system and the 5-HT3 receptor in schizophrenia.
Lennertz
Leonhard
L
Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Wagner
Michael
M
Frommann
Ingo
I
Schulze-Rauschenbach
Svenja
S
Schuhmacher
Anna
A
Kühn
Kai-Uwe
KU
Pukrop
Ralf
R
Klosterkötter
Joachim
J
Wölwer
Wolfgang
W
Gaebel
Wolfgang
W
Rietschel
Marcella
M
Häfner
Heinz
H
Maier
Wolfgang
W
Mössner
Rainald
R
D000328:Adult; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology*; D004493:Education; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D016366:Open Reading Frames / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011597:Psychomotor Performance / Q000187:drug effects; D044406:Receptors, Serotonin, 5-HT3 / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology
C476055:HTR3E protein, human; D044406:Receptors, Serotonin, 5-HT3