title: Two successive ocular malignancies in the same eye of a HIV-positive patient: a case report.
abstract: OBJECTIVE
  To report 2 successive ocular malignancies in the same eye of a HIV-positive patient at different CD4 counts.
  
  
  METHODS
  A 36-year-old retrovirus-positive male presented with no perception of light in the left eye of 1 month duration. CD4 counts were 44 cells/mm(3). Ultrasonography showed an exudative retinal detachment. Retinal biopsy suggested an intraocular B-cell lymphoma for which he received radiotherapy and chemotherapy. He presented 3 years later with a growth in the left eye with CD4 counts of 360 cells/mm(3).
  
  
  RESULTS
  Histopathology of enucleated eye showed a low-grade conjunctival squamous cell carcinoma. At 1-year follow-up, there is no mass in the anophthalmic socket.
  
  
  CONCLUSIONS
  This case highlights the development of 2 ocular malignancies in the same eye of an HIV-positive patient, at different CD4 counts, allowing the authors to speculate on additional factors involved in the development of the second malignancy.
authors.affiliation: Vittala International Institute of Ophthalmology & Prabha Eye Clinic and Research Center, Bangalore, India. kb_7375@yahoo.co.in
authors.forename: Kalpana
authors.initials: K
authors.lastname: Babu
authors.forename: Krishna R
authors.initials: KR
authors.lastname: Murthy
authors.forename: Subramanian
authors.initials: S
authors.lastname: Krishnakumar
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001766:Blindness / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D018791:CD4 Lymphocyte Count; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D015353:Eye Enucleation / Q000009:adverse effects; D005134:Eye Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D006801:Humans; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008297:Male; D016609:Neoplasms, Second Primary / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D011239:Prednisolone / Q000008:administration & dosage; D012163:Retinal Detachment / Q000209:etiology / Q000473:pathology; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone