Palatinose-blended sugar compared with sucrose: different effects on insulin sensitivity after 12 weeks supplementation in sedentary adults.
BACKGROUND
We investigated the effects of daily palatinose intake on the risk factors of metabolic syndrome in sedentary non-obese Japanese adults.


METHODS
Japanese adults (40 females and 10 males, age: 53 +/- 9 years, range: 31-72 years old) were randomized into two groups for a double-blind, placebo-controlled intervention study and given either 40 g/day palatinose-blended sugar (PS group) or 40 g/day sucrose (S group) in their diet for 12 weeks.


RESULTS
After the intervention, the insulin resistance index (HOMA-IR) had significantly decreased only in the PS group; the inter-group difference was significant at P = 0.006. Although the S group showed a significant increase in the leptin concentration and the systolic blood pressure, the PS group showed no significant changes; the inter-group differences were significant at P = 0.018 and P = 0.037, respectively.


CONCLUSIONS
Palatinose intake possibly improves insulin sensitivity when compared with sucrose intake.
Okuno
Masahiro
M
Research Laboratory, Mitsui Sugar Co., Ltd, Chigasaki, Kanagawa, Japan. masahiro.okuno@mitsui-sugar.co.jp
Kim
Maeng-Kyu
MK
Mizu
Masami
M
Mori
Mari
M
Mori
Hideki
H
Yamori
Yukio
Y
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D019422:Dietary Sucrose / Q000008:administration & dosage / Q000494:pharmacology*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D007534:Isomaltose / Q000031:analogs & derivatives* / Q000494:pharmacology; D020738:Leptin / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000517:prevention & control*; D008875:Middle Aged; D012307:Risk Factors; D057185:Sedentary Behavior; D013395:Sucrose / Q000494:pharmacology*
D019422:Dietary Sucrose; D020738:Leptin; D013395:Sucrose; D007534:Isomaltose; C008189:isomaltulose