title: [Successful cumulative treatment with pre/post-operative interferon-alpha, nephrectomy, and surgical resection of metastasis in advanced renal cell carcinoma : a case report].
abstract: A 55-year-old man was admitted with cough and sputum. Computed tomography revealed a left renal tumor, 7 cm in diameter, and multiple lung tumors with left pleural effusion. We considered nephrectomy impossible given his poor performance status. He received 500 x 104 IU/day of interferon alpha subcutaneously three times a week. Five months after the start of interferon alpha therapy, the renal and lung tumors were markedly reduced in size. Because of improvement of his condition and downsizing of tumors, radical nephrectomy was performed. In addition, interferon alpha therapy was continued for seven more months. At that point, all metastatic pulmonary lesions but one had disappeared. Interferon alpha therapy was then continued for one more year. About five years after the first admission, he is alive without evidence of disease.
authors.affiliation: The Department of Urology, Kouseikai Hospital, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hisamatsu
authors.forename: Syuji
authors.initials: S
authors.lastname: Yamashita
mesh_terms: D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000628:therapy*; D003131:Combined Modality Therapy; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000473:pathology / Q000628:therapy*; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy
chemical_list: D016898:Interferon-alpha