title: Total synthesis of (+)-decarbamoylsaxitoxin and (+)-gonyautoxin 3.
abstract: Facile construction of the complex saxitoxin (STX) skeleton is carried out by using a novel, conformationally controlled, guanidine cyclization process that relies on the use of neighboring group participation. The utility of this methodology is verified by its employment in syntheses of both natural and unnatural STX derivatives.
authors.affiliation: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, 2-24-16 Nakamachi, Koganei, Tokyo 184-8588, Japan.
authors.forename: Osamu
authors.initials: O
authors.lastname: Iwamoto
authors.forename: Kazuo
authors.initials: K
authors.lastname: Nagasawa
mesh_terms: D003500:Cyclization; D008958:Models, Molecular; D012530:Saxitoxin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D012530:Saxitoxin; C076432:decarbamoylneosaxitoxin; C013007:gonyautoxins