[Comparative study of resistance to acycloguanosine and acycloguanosine H-phosphonate in herpes simplex virus].
The ability of acycloguanosine H-phosphate to inhibit the reproduction of herpes simplex virus type 1 (HSV-1) variants, including its acycloguanosine (acyclovir)-resistant ones, was studied. Acycloguanosine H-phosphate-resistant HSV-1 variants were obtained. It was found that these variants were cross-resistant to thymidine kinase-dependent HSV reproduction inhibitors, but preserved sensitivity to Apa-A and phosphonoacetic acid.
Andronova
V L
VL
Galegov
G A
GA
Ias'ko
M V
MV
Kukhanova
M K
MK
Skoblov
Iu S
IuS
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D024882:Drug Resistance, Viral; D006561:Herpes Simplex / Q000821:virology*; D008826:Microbial Sensitivity Tests; D063065:Organophosphonates / Q000494:pharmacology*; D018139:Simplexvirus / Q000187:drug effects* / Q000502:physiology; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D063065:Organophosphonates; C550134:acycloguanosine H-phosphonate; D000212:Acyclovir