title: Post-prandial glucose levels and consumption of omega 3 fatty acids and saturated fats among two rural populations in Kenya.
abstract: BACKGROUND
  Amount and quality of dietary fat modifies glucose tolerance. Omega 3 Fatty Acids (n-3F A) are polyunsaturated fats, mainly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) found primarily in fish and they have a positive effect on glucose tolerance.
  
  
  OBJECTIVE
  To compare risk of type 2 diabetes mellitus (T2DM), as demonstrated thourough impaired glucose tolerance (IGT), and n-3FA intake among two rural populations.
  
  
  METHODS
  A descriptive, cross-sectional comparative study.
  
  
  METHODS
  Bondo District (Luo Community) and Kericho District (Kipsigis Community) of the Lake Victoria basin of Kenya.
  
  
  METHODS
  Sample of 150 individuals, aged above 18 years was randomly selected from each of the two communities.
  
  
  METHODS
  Impaired glucose tolerance (IGT) was measured according to World Health Organisation diagnostic criteria. The intake of n-3FA was determined using a 24 hour dietary recall and food frequency schedule. Data was analysed using SPSS and Pearson Correlation Coefficient was used to test correlation between n-3FA consumption and IGT. The inter-group comparisons were done using the t-test and analysis of variance.
  
  
  RESULTS
  The prevalence of IGT was 11.8% among the Kipsigis and 4.8% among the Luo (P<0.001). The mean EPA and DHA intake was found to be 0.29 g/day and 0.34 g/day respectively among the Luo and 0.01 g/day and 0.01 g/day among the Kipsigis (P<0.001). The relationship between 2 hour post-prandial glucose level and consumption of DHA was (r=-0.111, p<0.05), EPA (r=-0.123, p<0.05), polyunsaturated fatty acids (r=-0.128, p<0.05) and saturated fats (r=-0.002, p=0.973).
  
  
  CONCLUSIONS
  The levels of IGT were significantly lower (P<0.001) among the Luo, than among the Kipsigis. There was also evidence of significant inverse relationship between IGT and consumption of n-3FA and polyunsaturated fatty acids (PUFA) but no association between saturated fats intake and IGT. The saturated fat ingested did not affect the level of post-prandial glucose. The Luo who consumed higher n-3FA amounts, recorded lower levels of IGT than the Kipsigis who had significantly lower consumption.
  
  
  CONCLUSIONS
  Effective screening methods should be used at the existing health units to determine risk factors of type 2 diabetes mellitus like IGT among patients. This could help in advising them accordingly on lifestyle changes, especially concerning diet and beneficial fats.
authors.affiliation: Centre for Public Health Research, Kenya Medical Research Institute, P.O. Box 20752-00202, Nairobi, Kenya.
authors.forename: V W
authors.initials: VW
authors.lastname: Wanjihia
authors.forename: F K
authors.initials: FK
authors.lastname: Kiplamai
authors.forename: J N
authors.initials: JN
authors.lastname: Waudo
authors.forename: M K
authors.initials: MK
authors.lastname: Boit
mesh_terms: D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D004041:Dietary Fats / Q000008:administration & dosage*; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage; D005260:Female; D018149:Glucose Intolerance / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D015995:Prevalence; D012423:Rural Health; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated