26-Week carcinogenicity study of di-isodecyl phthalate by dietary administration to CB6F1-rasH2 transgenic mice.
This study examined the carcinogenic potential of di-isodecyl phthalate (DIDP) in rasH2 mice. DIDP was administered to 15 rasH2 mice/gender/group at dietary levels of 0, 0.1, 0.33, or 1% and 15 wild-type mice/gender/group at dietary levels of 0 and 1% for 26 weeks. Non-neoplastic changes were observed in the liver (parenchymal inflammation, fatty changes, diffuse hepatocyte hypertrophy with eosinophilic granules and focal necrosis) and kidneys (tubular basophilia and tubular hyperplasia) after administration of DIDP in the rasH2 and wild-type mice. In the neoplastic lesions, there were a higher number of hepatocellular adenomas in the male rasH2 mice receiving 1% DIDP, compared with the findings in the liver of control rasH2 mice or wild-type mice. The incidence of hepatocellular adenomas in the 0.1, 0.33, and 1% DIDP exposed rasH2 mice was 7% (1/15), 7% (1/15), and 33% (5/15), respectively. This study adds a set of results for an additional test chemical for the performance of the rasH2 short-term transgenic model to the existing database of 3 compounds (WY-14643, DEHP, and clofibrate) tested in the ILSI/HESI ACT project.
Cho
Wan-Seob
WS
Centre for Inflammation Research, The Queen's Medical Research Institute, The University of Edinburgh, UK.
Jeong
Jayoung
J
Choi
Mina
M
Park
Sue Nie
SN
Han
Beom Seok
BS
Son
Woo-Chan
WC
D018248:Adenoma, Liver Cell / Q000139:chemically induced*; D000284:Administration, Oral; D000818:Animals; D015197:Carcinogenicity Tests / Q000379:methods*; D002273:Carcinogens / Q000633:toxicity*; D002994:Clofibrate / Q000633:toxicity; D004051:Diethylhexyl Phthalate / Q000633:toxicity; D004195:Disease Models, Animal; D005260:Female; D011905:Genes, ras; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008297:Male; D008770:Methylnitrosourea / Q000633:toxicity; D051379:Mice; D008822:Mice, Transgenic; D010795:Phthalic Acids / Q000633:toxicity*; D011743:Pyrimidines / Q000633:toxicity; D013997:Time Factors
D002273:Carcinogens; D010795:Phthalic Acids; D011743:Pyrimidines; D008770:Methylnitrosourea; C006253:pirinixic acid; D004051:Diethylhexyl Phthalate; D002994:Clofibrate; C042080:diisodecyl phthalate