[The role of lectins from probiotic microorganisms in sustaining the macroorganism].
The notion of lectins has been expanded with special reference to lectins of probiotic microorganisms (LPM). New data on LPM and their properties are considered in the context of a new concept of systemic organization of LPM being developed. Conditions for complete separation of poly (N-acetylgalactosamine-?)-binding lectins and polyMan-?/oligomannoside/mannan-binding lectins are developed on the assumption that they contain a single carbohydrate-binding site in their structure. It is shown that strain typing of probiotic microorganisms is possible based not only on protein but also on LPM composition. The observed peculiarities of LPM functioning substantially extend the concept of informational superiority of integral interatomic networks over their isolated components. This approach makes it possible to set functioning of LPM systems against that of lectin systems of other components of human microbiota as prevailing in the support of the normal status of the macrorganism. The results demonsatrate the unique character of LPM systems and suggest good prospects for their application in medicine, biotechnology and nanotechnology.
Lakhtin
M V
MV
Aleshkin
V A
VA
Lakhtin
V M
VM
Nesvizhskiĭ
Iu V
IuV
Afanas'ev
S S
SS
Pospelova
V V
VV
D000818:Animals; D001709:Biotechnology / Q000379:methods; D003585:Cell Biology; D006801:Humans; D007422:Intestines / Q000382:microbiology*; D007777:Lactobacillaceae / Q000502:physiology*; D037102:Lectins / Q000502:physiology*; D019936:Probiotics / Q000494:pharmacology*
D037102:Lectins