title: Antibody persistence 12 months after a booster dose of meningococcal-C conjugated vaccine in the second year of life.
abstract: We report on the results of the 12-month follow-up of children aged 14 to 18 months who received primary and booster vaccinations with either a meningococcal-C vaccine conjugated to tetanus toxoid or CRM197. Seroprotection (92.8%) and geometric mean titers/serum bactericidal activity (410.5; 95% CI: 273.4-616.3) were higher in children receiving the meningococcal serogroup C tetanus toxoid conjugate, compared with 61.5% and serum bactericidal antibody geometric mean titer of 45.1 (95% CI: 28.5-71.3) when MenC-CRM197 conjugate was used.
authors.affiliation: Centro Superior de Investigación en Salud Pública, Valencia, Spain. diez_jav@gva.es
authors.forename: Javier
authors.initials: J
authors.lastname: Diez-Domingo
authors.forename: M Victoria
authors.initials: MV
authors.lastname: Planelles-Cantarino
authors.forename: Jose M
authors.initials: JM
authors.lastname: Baldo-Torrenti
authors.forename: Isabel
authors.initials: I
authors.lastname: Ubeda-Sansano
authors.forename: Angels
authors.initials: A
authors.lastname: Jubert-Rosich
authors.forename: Joan
authors.initials: J
authors.lastname: Puig-Barbera
authors.forename: M Victoria
authors.initials: MV
authors.lastname: Gutierrez-Gimeno
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D002675:Child, Preschool; D006801:Humans; D007117:Immunization, Secondary / Q000379:methods*; D007223:Infant; D008589:Meningococcal Infections / Q000517:prevention & control; D022401:Meningococcal Vaccines / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013745:Tetanus Toxoid / Q000276:immunology*; D013997:Time Factors; D014611:Vaccination / Q000379:methods*
chemical_list: D000907:Antibodies, Bacterial; D022401:Meningococcal Vaccines; D011135:Polysaccharides, Bacterial; D013745:Tetanus Toxoid; C052181:meningococcal group C polysaccharide-tetanus toxoid conjugate; C410218:serogroup C meningococcal conjugate vaccine