Fc gamma receptor biology and systemic lupus erythematosus.
The maintenance of immune homeostasis and the regulation of pro-inflammatory responses that underlie autoimmune pathology require a coordinated interplay between cytokines, cellular receptors and downstream signaling pathways. The family of fragment crystallizable receptors for immunoglobulin G (IgG) (Fc gammaR) represents a good example of how controlling the simultaneous triggering of activatory and/or inhibitory receptors results in a balanced immune response. Fc gammaRs play a crucial role in linking the antibody-mediated recognition of pathogens, allergens or auto-antigens to the cellular arm of the immune response. In this review, we detail how dysfunction in Fc gammaR pathways is linked to the development of the autoimmune disease, systemic lupus erythematosus.
Jovanovic
Vojislav
V
Department of Microbiology, Life Sciences Institute Immunology Program, The Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore.
Dai
Xilei
X
Lim
Yan Ting
YT
Kemeny
David M
DM
MacAry
Paul A
PA
D000818:Animals; D000917:Antibody Formation; D004195:Disease Models, Animal; D006801:Humans; D056747:Immunomodulation; D008180:Lupus Erythematosus, Systemic / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D051379:Mice; D017452:Receptors, IgG / Q000502:physiology*; D015398:Signal Transduction
D017452:Receptors, IgG