title: First Zn(II) bowl-complexes modeling the tris(histidine) metallo-site of enzymes.
abstract: The bowl-shaped resorcin[4]arene-based ligand was prepared as a model of the trihistidine coordination core present in many mononuclear metalloenzymes. The -CH(2)-O-CH(2)- linkers connecting the imidazoles to the cavity allow three imidazoles to simultaneously bind a metal ion, and favor cis-coordination of two exchangeable ligands. The corresponding mononuclear Zn(II) complexes were shown to be capable of the selective guest binding and exchange at both endo and exo positions.
authors.affiliation: Laboratoire de Chimie et de Biochimie pharmacologiques et toxicologiques, Université Paris Descartes, CNRS UMR 8601 45, 75006 Paris, France.
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Visnjevac
authors.forename: Jérôme
authors.initials: J
authors.lastname: Gout
authors.forename: Nicolas
authors.initials: N
authors.lastname: Ingert
authors.forename: Olivia
authors.initials: O
authors.lastname: Bistri
authors.forename: Olivia
authors.initials: O
authors.lastname: Reinaud
mesh_terms: D001665:Binding Sites; D006639:Histidine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015032:Zinc / Q000737:chemistry*
chemical_list: D006639:Histidine; D015032:Zinc