title: [Extended preoperative course of radiotherapy as component of combined and complex treatment of locally-advanced ampular rectal cancer].
abstract: Sixty-two patients were treated for locally-advanced ampular rectal cancer at the Center's Clinic (2004-2008). Extended preoperative course of radiotherapy plus 5 = fluorouracil chemomodification was given to 55 patients (group 1) and the same plus hyperthermia--to 27 (group 2). Radiation injuries were reported in 37.1% (group 1) and 29.6% in group 2. Surgical complications occurred in 10 (group 1) (32.2%) and 8 (group 2) (32%). Relapse was registered in 3 (group 1) (12.5%) and 3 (group 2) (13.6%). Overall 3-year survival (group 1)--82%; (group 2)--63.9%; 3-year relapse-free survival (group 1)--69.8%; (group 2)--52.2%.
authors.forename: K V
authors.initials: KV
authors.lastname: Semikopov
authors.forename: A V
authors.initials: AV
authors.lastname: Vazhenin
authors.forename: E A
authors.initials: EA
authors.lastname: Nadvikova
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Lukina
mesh_terms: D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D006979:Hyperthermia, Induced; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods*; D011379:Prognosis; D011832:Radiation Injuries / Q000209:etiology; D018714:Radiotherapy, Adjuvant / Q000379:methods; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil