Chemokines and their receptors in the allergic airway inflammatory process.
The development of the allergic airway disease conveys several cell types, such as T-cells, eosinophils, mast cells, and dendritic cells, which act in a special and temporal synchronization. Cellular mobilization and its complex interactions are coordinated by a broad range of bioactive mediators known as chemokines. These molecules are an increasing family of small proteins with common structural motifs and play an important role in the recruitment and cell activation of both leukocytes and resident cells at the allergic inflammatory site via their receptors. Trafficking and recruitment of cell populations with specific chemokines receptors assure the presence of reactive allergen-specific T-cells in the lung, and therefore the establishment of an allergic inflammatory process. Different approaches directed against chemokines receptors have been developed during the last decades with promising therapeutic results in the treatment of asthma. In this review we explore the role of the chemokines and chemokine receptors in allergy and asthma and discuss their potential as targets for therapy.
Velazquez
Juan Raymundo
JR
Unidad de Investigación Médica Zacatecas, Instituto Mexicano del Seguro Social, Zacatecas City, Mexico. velazquez_juan@hotmail.com.
Teran
Luis Manuel
LM
D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000276:immunology*; D002450:Cell Communication; D002465:Cell Movement; D018925:Chemokines / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000276:immunology*; D007111:Immunity, Cellular; D007167:Immunotherapy / Q000639:trends; D019707:Receptors, Chemokine / Q000276:immunology*
D018925:Chemokines; D019707:Receptors, Chemokine