title: [A multi-center randomized controlled trial on treatment of diarrhea-predominant irritable bowel syndrome by Chinese medicine syndrome-differentiation therapy].
abstract: OBJECTIVE
  To verify the clinical efficacy of Chinese Medicine syndrome-differentiation therapy in treating diarrhea-predominant irritable bowel syndrome IBS-D.
  
  
  METHODS
  With a blinded randomized controlled design adopted, 360 patients with IBS-D were randomly assigned to two groups, the treated group and the control group, they were treated with Chinese medicine and Pinaverium bromide for four weeks respectively.
  
  
  RESULTS
  Comprehensive evaluation showed that the total effective rate in the treated group was higher than that in the control group significantly (93.8% vs 81.3%, P<0.01). Efficacy assessment on symptoms (by scoring) showed that the efficacy in the treated group was better than that in the control group in aspects of improving abdominal pain (86.1% vs 70.3%), defecation coziness (involving the frequency of defecation, incidence of tenesmus in the latest 10 days and Bristol typing of stool characters), living interfering, and total BSS score (P<0.05 or P<0.01).
  
  
  CONCLUSIONS
  Chinese medicine syndrome-differentiation dependent therapy shows good efficacy in treating IBS-D.
authors.affiliation: Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010. zss2000@sohu.com
authors.forename: Sheng-sheng
authors.initials: SS
authors.lastname: Zhang
authors.forename: Hong-bing
authors.initials: HB
authors.lastname: Wang
authors.forename: Zhen-hua
authors.initials: ZH
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003967:Diarrhea / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D043183:Irritable Bowel Syndrome / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D016037:Single-Blind Method; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D004365:Drugs, Chinese Herbal