title: 2-alkyl-2-carboxyazetidines as γ-turn inducers: incorporation into neurotrophin fragments.
abstract: Conveniently substituted 2-alkyl-2-carboxyazetidine amino acids have been incorporated into NGF and NT3 tetrapeptide sequences to investigate their utility as reverse turn inducers (γ- vs. β-turns). Despite the presence of an Asp residue at i position, highly preferred in β-turns, molecular modeling and NMR studies indicated that the azetidine-containing peptides mainly stabilized γ-turn conformations.
authors.affiliation: Instituto de Química Médica, CSIC, Juan de la Cierva 3, 28006, Madrid, Spain.
authors.forename: José Luis
authors.initials: JL
authors.lastname: Baeza
authors.forename: M Angeles
authors.initials: MA
authors.lastname: Bonache
authors.forename: M Teresa
authors.initials: MT
authors.lastname: García-López
authors.forename: Rosario
authors.initials: R
authors.lastname: González-Muñiz
authors.forename: Mercedes
authors.initials: M
authors.lastname: Martín-Martínez
mesh_terms: D001384:Azetidines / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D009414:Nerve Growth Factors / Q000737:chemistry*; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D001384:Azetidines; D009414:Nerve Growth Factors; D010446:Peptide Fragments