Syntheses of amorphous and crystalline cupric sulfide nanoparticles and study on the specific activities on different cells.
Copper sulfide amorphous nanoparticles and nanocrystals were prepared successfully by a special process. These CuS nanoparticles could specifically and significantly induce the apoptosis and inhibit the proliferation of human cancer cells rather than normal cells. Moreover, the biological activities of these nanoparticles are related to their polymorphs.
Guo
Yuming
Y
College of Chemistry and Environmental Science, Henan Normal University, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, Xinxiang 453007, PR China.
Zhang
Jie
J
Yang
Lin
L
Wang
Huajie
H
Wang
Feifei
F
Zheng
Zhi
Z
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003300:Copper / Q000737:chemistry / Q000494:pharmacology*; D003460:Crystallization; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D013440:Sulfides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013499:Surface Properties; D014961:X-Ray Diffraction
D000970:Antineoplastic Agents; D013440:Sulfides; C099343:cuprous sulfide; D003300:Copper