Rhodium-catalyzed oxidative coupling/cyclization of 2-phenylindoles with alkynes via C-H and N-H bond cleavages with air as the oxidant.
The straightforward and efficient synthesis of indolo[2,1-a]isoquinoline derivatives has been achieved by the rhodium-catalyzed aerobic oxidative coupling/cyclization of 2-phenylindoles with alkynes. Some of the polycyclic products exhibit solid-state fluorescence.
Morimoto
Keisuke
K
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Hirano
Koji
K
Satoh
Tetsuya
T
Miura
Masahiro
M
D000388:Air; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D005453:Fluorescence; D006868:Hydrolysis; D007211:Indoles / Q000737:chemistry*; D016877:Oxidants / Q000737:chemistry*; D010084:Oxidation-Reduction; D012238:Rhodium / Q000737:chemistry*
D000480:Alkynes; D007211:Indoles; D016877:Oxidants; D012238:Rhodium; C542223:2-phenylindole