title: A single-centre retrospective review of unilateral and bilateral Dysport injections in adductor spasmodic dysphonia.
abstract: We reviewed the results and side-effect profile of the Dysport preparation of botulinum toxin A (BTA) in the management of the adductor spasmodic dysphonia. We performed 272 injection episodes in 68 patients, 42 (62%) female, 26 (38%) male. A total of 116 of these injections were unilateral, and 156 were bilateral; 94% of the injections were considered to have been successful with a voice score of 2 or higher. The mean duration of effect (injection intervals) was 128.8 days in the unilateral cohort and 118.7 days in the bilateral (P > 0.05). We injected a relatively lower dose of BTA for unilateral injection episodes in our institution compared to those reported by others to produce comparable results and side-effect profiles.
authors.affiliation: The Royal National Throat Nose and Ear Hospital, London, UK. belmiyeh@doctors.net.uk
authors.forename: Behrad
authors.initials: B
authors.lastname: Elmiyeh
authors.forename: Vyas M N
authors.initials: VM
authors.lastname: Prasad
authors.forename: Tahwinder
authors.initials: T
authors.lastname: Upile
authors.forename: Nick
authors.initials: N
authors.lastname: Saunders
authors.forename: Bryan D
authors.initials: BD
authors.lastname: Youl
authors.forename: Ruth
authors.initials: R
authors.lastname: Epstein
authors.forename: John S
authors.initials: JS
authors.lastname: Rubin
mesh_terms: D019274:Botulinum Toxins, Type A / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D015331:Cohort Studies; D055154:Dysphonia / Q000188:drug therapy*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007267:Injections / Q000379:methods; D008297:Male; D008875:Middle Aged; D009465:Neuromuscular Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D014831:Voice / Q000187:drug effects
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A