Differing effect of systemic anti psoriasis therapies on platelet physiology--a case report and review of literature.
BACKGROUND
Psoriasis is a common, chronic relapsing inflammatory skin disease. Lately, there is increasing evidence that psoriasis is more than "skin deep". Epidemiological studies showed that severe psoriasis might have also important systemic manifestations such as metabolic deregulations, cardiovascular disease (CVD) and increased mortality. Moreover, recently psoriasis patients were found to have platelet hyperactivity.


METHODS
This is a case report and review of the literature. We present a patient with long standing severe psoriasis vulgaris with marked thrombocytosis. His thrombocytosis did not correlate with disease severity but rather with the different treatments that he was exposed to, subsiding only during treatment with anti Tumor Necrosis Factor (TNF)- agents. A literature review revealed that in rheumatoid arthritis, another systemic inflammatory disease; interleukin (IL)-6 might be implicated in causing thrombocytosis.


CONCLUSIONS
This unique case report illustrates that different systemic treatments for psoriasis might have implications beyond the care of skin lesions. This insight is especially important in psoriasis patients in view of their deranged hemostatic balance toward a prothrombotic state, which might increase the risk of thrombosis and CVD. Therefore, further studies analyzing the effect of different drugs on platelets physiology are warranted.
Davidovici
Batya B
BB
Laboratory for Investigative Dermatology, The Rockefeller University, New York, NY, USA.
Sullivan-Whalen
Mary M
MM
Gilleaudeau
Patricia
P
Krueger
James G
JG
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D010976:Platelet Count; D011565:Psoriasis / Q000097:blood / Q000188:drug therapy*; D013922:Thrombocytosis / Q000097:blood / Q000139:chemically induced*
D007166:Immunosuppressive Agents