[Growth inhibition and apoptosis-inducing effects of phytic acid in human gastric carcinoma cells].
OBJECTIVE
To explore the growth inhibition and apoptosis-inducing effects of phytic acid in human gastric cancer SGC-7901 cells.


METHODS
The growth inhibition action of phytic acid on SGC-7901 cells was examined by MTT assay. AO/EB fluorescence staining and DNA ladder assay were applied to study the proapoptosis effects of phytic acid. The expression of apoptosis relative proteins, P53, were analyzed by using immune histochemisty method.


RESULTS
Phytic acid treatment significantly inhibited the growth of human gastric cancer cell SGC-7901 and markedly caused their apoptosis following downregulation of P53 protein expression.


CONCLUSIONS
The downregulation of apoptosis relative protein P53 expression was the possible mechanism of phytic acid induced growth inhibition and apoptosis in SGC-7901 cells.
Wang
Lu
L
Harbin Institute of Technology, Harbin 150090, China. wanglu_tianfeng@yahoo.com.cn
Cheng
Cuilin
C
Zhao
Haitian
H
Yang
Zhiping
Z
Wei
Honglian
H
Cui
Hongbin
H
D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D010833:Phytic Acid / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
D000970:Antineoplastic Agents; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D010833:Phytic Acid