In vitro / in vivo evaluation of NCDS-micro-fabricated biodegradable implant.
Using the nano-composite deposition system (NCDS) as a microfabrication technique, implantable scaffolds were prepared with poly(DL-lactide-co-glycolide)(85:15) [PLGA(85:15)] as a biodegradable polymer. 5-Fluorouracil (5-FU) was used as a model drug, and hydroxyapatite (HA) was incorporated as a release modifier. In vitro drug release was evaluated and we confirmed that HA could control the release of drug from the prepared scaffolds, especially in the initial phase of the release. Furthermore, in vivo tests demonstrated that the microfabricated scaffold with pores was useful in reducing immune response and maintained its original shape, indicating that the drug delivery system was highly biocompatible.
Park
Chun-Woong
CW
School of Mechanical, Sungkyunkwan University, Suwon, 440-746, Korea.
Rhee
Yun-Seok
YS
Park
Sung-Hoon
SH
Danh
Son Dao
SD
Ahn
Sung-Hoon
SH
Chi
Sang-Cheol
SC
Park
Eun-Seok
ES
D020341:Absorbable Implants; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D017886:Durapatite / Q000737:chemistry; D005472:Fluorouracil / Q000737:chemistry*; D005549:Foreign-Body Reaction / Q000276:immunology; D007249:Inflammation / Q000276:immunology; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry* / Q000276:immunology; D008297:Male; D008422:Materials Testing; D053761:Nanocomposites; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016062:Porosity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D054457:Tissue Scaffolds
D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D017886:Durapatite; D005472:Fluorouracil