Conformational changes in receptor tyrosine kinase signaling: an ErbB garden of delights.
The ErbB family of receptor tyrosine kinases plays important roles in cell proliferation, differentiation, and apoptosis. Recent structural studies of these receptors have demonstrated dramatic conformational effects that are critical to their ligand binding and activation, and have shown that these receptors provide levels of control beyond the classic dimerization/activation mechanism. These results indicate that this class of receptors has evolved subtle regulatory mechanisms via genetic and protein structural changes to influence their effects on cell behaviors.
Carraway
Kermit L
KL
Departments of Cell Biology & Anatomy and Biochemistry & Molecular Biology, University of Miami School of Medicine, 1550 NW 10 Avenue, Miami, FL 33136, USA.
Kozloski
Goldi A
GA