Vitamin E and risk of cardiovascular diseases: a review of epidemiologic and clinical trial studies.
Cardiovascular diseases are the leading cause of worldwide mortality. There is strong epidemiologic evidence for a beneficial effect of vitamin E on cardiovascular disease risk. However, conflicting results have been reported by intervention studies. To assess the potential benefit of vitamin E intake on the risk of cardiovascular diseases, fifty-nine published reports from observational studies, retrospective and prospective, randomised clinical trials, meta-analyses as well as pooling analyses were reviewed. The paper provides a detailed discussion about design, quality and limitations of these studies with regard to the evidence of the hypothesized relationship between vitamin E and cardiovascular diseases.
Cordero
Zorabel
Z
Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrucke, Nuthetal, Germany. gonzalez@mail.dife.de
Drogan
Dagmar
D
Weikert
Cornelia
C
Boeing
Heiner
H
D000975:Antioxidants / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control*; D004032:Diet; D014943:Global Health; D006801:Humans; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D014810:Vitamin E