[A comparative study on behaviors of two depression models in rats induced by chronic forced swimming stress].
OBJECTIVE
To compare the behaviors of rats with depressions induced by chronic forced swimming stress under two different conditions.


METHODS
Eighteen male rats were randomly divided into 3 groups, with 6 rats in each group. The rats in the control group (C group) were not forced into swimming, while the rats in the stress groups (S1 and S2) were forced to swim for 14 consecutive days. The rats in S1 group and S2 group swam for five minutes every morning, in water with (23 +/- 1) degree C, and (10 +/- 0.5) degree C in temperature, respectively. The weight gain, food intake, open-field test and saccharin solution test were observed on the seventh day and fourteenth day.


RESULTS
On the seventh day following chronic swim stress, the rats in the S2 group had significant lower ratio in weight gain and food intake than the controls (P < 0.05). On the fourteenth day, the rats in the S2 group had significant lower ratio in weight gain (12.26 +/- 4.04)%, food intake (9.49 +/- 0.96)%, sucrose intake (28.63 +/- 3.51) g, and preference for saccharin solution (76.25 +/- 2.51)%, and less number of crossing (12.17 +/- 9.00) and times of rearing (3.17 +/- 3.60) than the controls (P < 0.05). The rats in the S1 group had significant lower ratio in weight gain and food intake than the controls on the seventh day following forced swimming. On the fourteenth day, the rats in the S1 group still had lower ratio in weight gain, but had higher ratio in food intake and preference for saccharin solution, and greater number of crossing than the controls.


CONCLUSIONS
Chronic forced swimming at a lower temperature could induce depression better than at a higher temperature.
Han
Ming-Fei
MF
Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China.
Gao
Dong
D
Sun
Xue-Li
XL
D000818:Animals; D001522:Behavior, Animal; D003080:Cold Temperature; D003863:Depression / Q000209:etiology; D004195:Disease Models, Animal; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013312:Stress, Physiological; D013550:Swimming; D013997:Time Factors