The iPS technique provides hope for Parkinson's disease treatment.
More recently, reprogramming of somatic cells to an embryonic stem cell-like state presents a milestone in the realm of stem cells, making it possible to derive all cell types from any patients bearing specific genetic mutations. With the development of induced pluripotent stem (iPS) cells, we are now able to use the derivatives of iPS cells to study the mechanisms of disease and to perform drug screening and toxicology testing. In addition, differentiated iPS cells are now close to be used in clinical practice. Here we review the progress of iPS technique and the possible application in the area of Parkinson's disease treatment.
Xu
Liang
L
Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, No.197, Rui Jin Er Road, Shanghai, 200025, China.
Tan
Yu-Yan
YY
Ding
Jian-Qing
JQ
Chen
Sheng-Di
SD
D002454:Cell Differentiation; D065150:Cellular Reprogramming / Q000502:physiology; D053595:Embryonic Stem Cells; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000502:physiology* / Q000637:transplantation; D008954:Models, Biological; D010300:Parkinson Disease / Q000628:therapy*