title: Divergent effects on phagocytosis by macrophage-derived oxygen radicals.
abstract: Clearance of senescent cells from damaged tissue is a crucial step to successfully resolve an inflammatory response. Poor clearance has been attributed to defects in neutrophil apoptosis, a process that is regulated in part by reactive oxygen species (ROS) produced by activated neutrophils. Using ROS-deficient and wild-type macrophages treated with extracellular ROS scavengers we demonstrate that macrophage-derived ROS also influence phagocytosis and do so by direct and indirect mechanisms.
authors.affiliation: Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden.
authors.forename: Kelly L
authors.initials: KL
authors.lastname: Brown
authors.forename: Karin
authors.initials: K
authors.lastname: Christenson
authors.forename: Anna
authors.initials: A
authors.lastname: Karlsson
authors.forename: Claes
authors.initials: C
authors.lastname: Dahlgren
authors.forename: Johan
authors.initials: J
authors.lastname: Bylund
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000276:immunology; D002469:Cell Separation; D005434:Flow Cytometry; D006801:Humans; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000172:deficiency / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases / Q000172:deficiency / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D009504:Neutrophils / Q000276:immunology / Q000473:pathology; D010587:Phagocytosis / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000276:immunology* / Q000378:metabolism
chemical_list: D008562:Membrane Glycoproteins; D017382:Reactive Oxygen Species; C488842:Cybb protein, mouse; D000074662:NADPH Oxidase 2; D019255:NADPH Oxidases