Interference of Pseudomonas aeruginosa signalling and biofilm formation for infection control.
Pseudomonas aeruginosa is the best described bacterium with regards to quorum sensing (QS), in vitro biofilm formation and the development of antibiotic tolerance. Biofilms composed of P. aeruginosa are thought to be the underlying cause of many chronic infections, including those in wounds and in the lungs of patients with cystic fibrosis. In this review, we provide an overview of the molecular mechanisms involved in QS, QS-enabled virulence, biofilm formation and biofilm-enabled antibiotic tolerance. We now have substantial knowledge of the multicellular behaviour of P. aeruginosa in vitro. A major task for the future is to investigate how such in vitro data correlate with the in vivo behaviour of P. aeruginosa, and how to treat chronic infections of this bacterium in patients.
Bjarnsholt
Thomas
T
Department of International Health, Immunology and Microbiology, University of Copenhagen, 2200 Copenhagen, Denmark.
Tolker-Nielsen
Tim
T
Høiby
Niels
N
Givskov
Michael
M
D000818:Animals; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development*; D002908:Chronic Disease; D006801:Humans; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000382:microbiology* / Q000473:pathology; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology*; D015398:Signal Transduction / Q000187:drug effects