Efficient DNA photocleavage by [Ru(bpy)2(dppn)]2+ with visible light.
The population and reactivity of two low-lying excited states in [Ru(bpy)(2)(dppn)](2+) (bpy = 2,2'-bipyridine, dppn = benzo[i]dipyrido[3,2-a:2',3'-c]phenazine), a weakly emissive (3)MLCT state and a long-lived ligand-centered (3)pipi* state, lead to efficient photoinduced DNA damage. Irradiation with visible light results in nearly complete DNA cleavage within 30 s (lambda(irr) > or = 455 nm), likely from the combined action of guanine oxidation and the production of reactive oxygen species derived from (1)O(2).
Sun
Yujie
Y
Department of Chemistry, The Ohio State University, Columbus, OH 43210, USA.
Joyce
Lauren E
LE
Dickson
Nicole M
NM
Turro
Claudia
C
D056831:Coordination Complexes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000528:radiation effects; D053837:DNA Cleavage; D006147:Guanine / Q000737:chemistry; D008027:Light; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D010782:Photolysis; D017382:Reactive Oxygen Species / Q000378:metabolism; D012428:Ruthenium / Q000737:chemistry*
D056831:Coordination Complexes; D009942:Organometallic Compounds; D017382:Reactive Oxygen Species; D006147:Guanine; D012428:Ruthenium; D004247:DNA