White matter connectivity in bipolar disorder.
There is evidence that intra- and inter-hemispheric white matter communication, mainly fronto-limbic and callosal connectivity, is impaired in bipolar disorder as reported in several magnetic resonance (MR) diffusion imaging studies. In this review we will discuss diffusion imaging studies that examined white matter integrity in patients with bipolar disorder, trying to outline future research strategies.
Brambilla
Paolo
P
Division of Psychiatry, University of Edinburgh, Royal Edinburgh Hospital, Edinburgh EH10 5HF, UK.
Bellani
Marcella
M
Yeh
Ping-Hong
PH
Soares
Jair C
JC
Tansella
Michele
M
D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000473:pathology / Q000503:physiopathology*; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D003337:Corpus Callosum / Q000473:pathology / Q000503:physiopathology; D038524:Diffusion Magnetic Resonance Imaging; D004292:Dominance, Cerebral / Q000502:physiology; D005625:Frontal Lobe / Q000473:pathology / Q000503:physiopathology; D006179:Gyrus Cinguli / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008032:Limbic System / Q000473:pathology / Q000503:physiopathology; D009413:Nerve Fibers, Myelinated / Q000473:pathology / Q000502:physiology*; D009415:Nerve Net / Q000473:pathology / Q000503:physiopathology; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology*; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology; D055815:Young Adult