title: [An outbreak of human rabies transmitted by a cat in the town of Santander de Quilichao, Colombia, 2008].
abstract: OBJECTIVE
  A sylvatic rabies outbreak during March 2008 caused two human deaths in the town of Santander de Quilichao in Cauca, Colombia. This article describes the diagnostic laboratory techniques used, the field investigation and focus control used, as well as this outbreak's epidemiological significance and implications for public health.
  
  
  METHODS
  Rabies was diagnosed by direct immunofluorescence, biological tests involving inoculating mice, histopathology and immunohistochemistry and then typed by using monoclonal antibodies. Field investigation focused on searching for human and animal contacts, identifying suspicious cases and conducting an institutional search for rabid accidents. Focus control consisted of post-exposure treatment of the exposed population, vaccinating dogs and cats, collecting and eliminating stray animals and educating the community.
  
  
  RESULTS
  Two human rabies cases were confirmed in the laboratory and another was inferred in a cat by epidemiological nexus. Antigenic variant 3 was isolated from the human cases. 11,369 dogs, 3,325 cats and 217 humans were vaccinated.
  
  
  CONCLUSIONS
  This study confirmed that rabies in the wild represents a threat for humans. The outbreak described here originated in vampire bats and was transmitted to humans by a cat, pointing out the nexus between wild rabies and the urban ecosystem which cats represent, thereby becoming a target for rabies' control and prevention activities. This study underlines the urgency of implementing and maintaining rabies control and prevention activities in the wild to minimise its impact on humans.
authors.affiliation: Laboratorio de Virología, Laboratorio de Patología, Subdirección de Vigilancia y Control en Salud Pública, Instituto Nacional de Salud, Bogotá, Colombia. apaezm@ins.gov.co
authors.forename: Andrés
authors.initials: A
authors.lastname: Paez
authors.forename: Luis
authors.initials: L
authors.lastname: Polo
authors.forename: Damaris
authors.initials: D
authors.lastname: Heredia
authors.forename: Constanza
authors.initials: C
authors.lastname: Nuñez
authors.forename: Milena
authors.initials: M
authors.lastname: Rodriguez
authors.forename: Carlos
authors.initials: C
authors.lastname: Agudelo
authors.forename: Edgar
authors.initials: E
authors.lastname: Parra
authors.forename: Andrea
authors.initials: A
authors.lastname: Paredes
authors.forename: Teresa
authors.initials: T
authors.lastname: Moreno
authors.forename: Gloria
authors.initials: G
authors.lastname: Rey
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000635:transmission; D002415:Cats; D002648:Child; D003105:Colombia; D004196:Disease Outbreaks; D006801:Humans; D008297:Male; D011818:Rabies / Q000453:epidemiology* / Q000635:transmission* / Q000662:veterinary