Two acetylated megastigmane glycosides from the leaves of Ilex paraguariensis.
Two acetylated megastigmane glycosides, matenosides A (1) and B (2), have been isolated from the MeOH extract of Ilex paraguariensis leaves, and their structures were elucidated on the basis of spectroscopic analysis. Compounds 1 and 2 exhibited human neutrophil elastase (HNE) inhibitory activity with IC(50) values of 50.4 muM and 11.1 microM, respectively.
Xu
Guang-Hua
GH
Korea Research Institute of Bioscience and Biotechnology, Daejeon, 305-806, Korea.
Kim
Young-Hee
YH
Choo
Soo-Jin
SJ
Ryoo
In-Ja
IJ
Yoo
Jae-Kuk
JK
Ahn
Jong-Seog
JS
Yoo
Ick-Dong
ID
D000107:Acetylation; D002851:Chromatography, High Pressure Liquid; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D030019:Ilex paraguariensis / Q000737:chemistry*; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors / Q000378:metabolism; D015394:Molecular Structure; D045792:Norisoprenoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves; D053491:Proteinase Inhibitory Proteins, Secretory / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013329:Structure-Activity Relationship
D006027:Glycosides; D045792:Norisoprenoids; D053491:Proteinase Inhibitory Proteins, Secretory; D019272:Leukocyte Elastase