Postradiotherapy plasma lutein, alpha-carotene, and beta-carotene are positively associated with survival in patients with head and neck squamous cell carcinoma.
The aim of our study was to compare plasma carotenoids (i.e., biomarkers of fruits and vegetables intake) and tocopherols in 29 head and neck squamous cell carcinoma (HNSCC) patients with 51 healthy controls and to explore the possibility whether these plasma antioxidants could be related to outcome among patients. The patients' blood samples were taken at the end of radiotherapy. We observed that plasma lutein, zeaxanthin, alpha-carotene, beta-carotene, lycopene, and total carotenoids were significantly lower in HNSCC patients than controls. Among the patients, 18 died and 11 were still alive during median follow-up of 55 mo for survivors. We found a significant positive association between postradiotherapy plasma carotenoids (lutein, alpha-carotene, and beta-carotene) and progression-free survival in these patients. This study indicates that increasing postradiotherapy plasma carotenoid concentration may reduce risk of premature death or recurrence of tumor in HNSCC patients. Increasing plasma carotenoid concentration should be done by increasing intake of carotenoid-rich fruits and vegetables, as other studies have shown either no or negative effects due to use of carotenoid supplements.
Sakhi
Amrit Kaur
AK
Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway.
Bøhn
Siv Kjølsrud
SK
Smeland
Sigbjørn
S
Thoresen
Magne
M
Smedshaug
Guro Berge
GB
Tausjø
Johan
J
Svilaas
Arne
A
Karlsen
Anette
A
Russnes
Kjell Magne
KM
Svilaas
Tone
T
Blomhoff
Rune
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000401:mortality / Q000532:radiotherapy*; D002338:Carotenoids / Q000097:blood*; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D014975:Lutein / Q000097:blood*; D008297:Male; D008875:Middle Aged; D024505:Tocopherols / Q000097:blood; D019207:beta Carotene / Q000008:administration & dosage / Q000097:blood*
D019207:beta Carotene; D002338:Carotenoids; C041635:alpha-carotene; D024505:Tocopherols; D014975:Lutein