title: Enhanced osteointegration of orthopaedic implant gradient coating composed of bioactive glass and nanohydroxyapatite.
abstract: We conducted histologic and histomorphometric studies to evaluate the osteointegration of gradient coatings composed of bioactive glass and nanohydroxyapatite (BG-nHA) on titanium-alloy orthopaedic implants and surrounding bone tissue in vivo. Titanium-alloy implants with a gradient coating (gradient coating group), uncoated implants (uncoated group), and implants with a conventional hydroxyapatite (HA) coating (HA coating group) were randomly implanted in bilateral femoral condyles of 36 male New Zealand rabbits. The bone-implant contact at 12 and 24 weeks and the new bone volume in the notch created for observing bone ingrowth at 4, 12, and 24 weeks were found greater in the gradient coating group than those in both the uncoated group and the HA coating group (p < 0.05). Fluorescence micrographs showed active osteogenesis in the gradient coating group at 4 weeks after implantation. These findings indicated that BG-nHA gradient coatings could enhance the osteointegration of orthopaedic implant.
authors.affiliation: Department of Orthopedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Xin-Hui
authors.initials: XH
authors.lastname: Xie
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Yu
authors.forename: Shao-Xian
authors.initials: SX
authors.lastname: Zeng
authors.forename: Rui-Lin
authors.initials: RL
authors.lastname: Du
authors.forename: Yu-Huai
authors.initials: YH
authors.lastname: Hu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yuan
authors.forename: Er-Yi
authors.initials: EY
authors.lastname: Lu
authors.forename: Ke-Rong
authors.initials: KR
authors.lastname: Dai
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Tang
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000473:pathology; D002516:Ceramics; D017886:Durapatite / Q000737:chemistry*; D005269:Femur / Q000473:pathology; D008297:Male; D010012:Osteogenesis / Q000502:physiology*; D019736:Prostheses and Implants; D011817:Rabbits; D014025:Titanium
chemical_list: C022107:Bioglass; C070282:Ti-6Al-7Nb alloy; D017886:Durapatite; D014025:Titanium