title: Chemical constituents of Periploca forrestii and their cytotoxicity activity.
abstract: OBJECTIVE
  To investigate the chemical constituents of the roots of Periploca forrestii and evaluate their cytotoxicity activities.
  
  
  METHODS
  Silica gel column chromatography was employed for the isolation and purification of chemical constituents. The structures were identified on the basis of spectral data and the cytotoxicities of compounds 2-4 were investigated by several tumors cell lines including blood tumor (HL-60, CCRT-CEM), prostate tumor (PC-3, DU-145) and Melanoma (UACC-62).
  
  
  RESULTS
  Four compounds were isolated and identified as follows, lupeol-20(29)-en-3-nonadecanoate (1), peroiforoside I (2), 3beta,5beta,14beta-3OH-8beta-H-car-20(22)-enolide (3), perplocin (4).
  
  
  CONCLUSIONS
  Compound 1 is a new lupane triterpene fatty acid ester. Compounds 2-4 showed notable cytotoxicity against all tumor lines.
authors.affiliation: The State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sinences, Kunming 650204, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Wang
authors.forename: Cuifang
authors.initials: C
authors.lastname: Wang
authors.forename: Jinxiong
authors.initials: J
authors.lastname: Chen
authors.forename: Jiang
authors.initials: J
authors.lastname: Du
authors.forename: Dewen
authors.initials: D
authors.lastname: Qiu
authors.forename: Minghua
authors.initials: M
authors.lastname: Qiu
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D031109:Periploca / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; D014315:Triterpenes