Synthesis and antimicrobial activity of new substituted fused 1,2,4-triazole derivatives.
A number of new substituted 1,2,4-triazole, 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole and 1,2,4-triazolo[3,4-b]1,3,4-thiadiazine derivatives were synthesized and tested for their antimicrobial activity against Bacillus subtilis (Gram-positive), Pseudomonas aeruginosa (Gram-negative), and Streptomyces species (Actinomycetes). The synthesized compounds displayed different degrees of antimicrobial activities or inhibitory actions.
El-Sayed
Wael A
WA
Photochemistry Department, National Research Centre, Cairo, Egypt. waelshendy@gmail.com
Ali
Omar M
OM
Hathoot
Marwa M
MM
Abdel-Rahman
Adel A-H
AA
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013302:Streptomyces / Q000187:drug effects*; D013829:Thiadiazines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D013829:Thiadiazines; D013830:Thiadiazoles; D014230:Triazoles; C045575:1,2,4-triazole