title: Structure and anti-TB activity of trachylobanes from the liverwort Jungermannia exsertifolia ssp. cordifolia.
abstract: In the critical search for new antituberculosis lead compounds, bryophytes represent a largely untapped resource of chemically diverse structures. From the liverwort Jungermannia exsertifolia subsp. cordifolia, 11 new trachylobane diterpene derivatives, as well as three known compounds, were isolated. Their structures were elucidated by spectroscopic means, and full (1)H NMR spin analysis of one model compound confirmed the relative configurational assignments of the congeners. Four of the isolates exhibited noticeable activity against virulent Mycobacterium tuberculosis H(37)Rv with minimal inhibitory concentrations of 61-24 microg/mL. This finding suggests that bryophytes in general and trachylobanes in particular deserve further attention in the search for new antimycobacterial leads.
authors.affiliation: Pharmakognosie und Analytische Phytochemie, Universität des Saarlandes, Saarbrücken, Germany. jochen.scher@web.de
authors.forename: Jochen M
authors.initials: JM
authors.lastname: Scher
authors.forename: Andreas
authors.initials: A
authors.lastname: Schinkovitz
authors.forename: Josef
authors.initials: J
authors.lastname: Zapp
authors.forename: Yuehong
authors.initials: Y
authors.lastname: Wang
authors.forename: Scott G
authors.initials: SG
authors.lastname: Franzblau
authors.forename: Hans
authors.initials: H
authors.lastname: Becker
authors.forename: David C
authors.initials: DC
authors.lastname: Lankin
authors.forename: Guido F
authors.initials: GF
authors.lastname: Pauli
mesh_terms: D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D035926:Hepatophyta / Q000737:chemistry*; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D019906:Nuclear Magnetic Resonance, Biomolecular; D013557:Switzerland
chemical_list: D000995:Antitubercular Agents; D004224:Diterpenes