title: Search for new and novel chemotherapeutics for the treatment of human malignancies.
abstract: One of the hallmarks of cancer is the uncontrolled cell proliferation which causes more deaths among the human diseases throughout the globe. One in eight deaths worldwide are due to cancer, it is the second and third leading cause of death in economically developed and developing countries, respectively. As it is caused by both external and internal factors, a balanced approach to cancer control includes prevention, early detection, and effective treatment. In the treatment of cancer, chemotherapy is one of the practical methods and is widely used employing drugs that can destroy cancer cells by impeding their growth and reproduction. Despite the great strides made in the treatment of cancer over the past 50 years, it continues to be a major health concern and therefore, extensive efforts have been devoted to search for new scaffolds to develop chemotherapeutics. In this perspective, over the past two decades from this laboratory extensive efforts have been made in the development of new chemotherapeutic agents for the treatment of cancer. In this review, glimpses on types of current chemotherapeutic agents based on their action of inhibition and the new molecules that are being developed based on the scaffolds such as pyrrolo[2,1-c][1,4]benzodiazepines, podophyllotoxins, benzothiadiazine 1,1-dioxides, naphthalimides and monastrol across the world as well as in this laboratory have been articulated.
authors.affiliation: Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad-500 607, India. ahmedkamal@iict.res.in
authors.forename: Ahmed
authors.initials: A
authors.lastname: Kamal
authors.forename: Shaik
authors.initials: S
authors.lastname: Azeeza
authors.forename: E Vijaya
authors.initials: EV
authors.lastname: Bharathi
authors.forename: M Shaheer
authors.initials: MS
authors.lastname: Malik
authors.forename: Rajesh V C R N C
authors.initials: RV
authors.lastname: Shetti
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D001569:Benzodiazepines / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D001581:Benzothiadiazines / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D006801:Humans; D053644:Naphthalimides / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy*; D011034:Podophyllotoxin / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use; D013871:Thiones / Q000138:chemical synthesis / Q000737:chemistry / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D001581:Benzothiadiazines; D053644:Naphthalimides; D011743:Pyrimidines; D013871:Thiones; D001569:Benzodiazepines; C400223:monastrol; D011034:Podophyllotoxin