title: Vitamin E and risk of cardiovascular diseases: a review of epidemiologic and clinical trial studies.
abstract: Cardiovascular diseases are the leading cause of worldwide mortality. There is strong epidemiologic evidence for a beneficial effect of vitamin E on cardiovascular disease risk. However, conflicting results have been reported by intervention studies. To assess the potential benefit of vitamin E intake on the risk of cardiovascular diseases, fifty-nine published reports from observational studies, retrospective and prospective, randomised clinical trials, meta-analyses as well as pooling analyses were reviewed. The paper provides a detailed discussion about design, quality and limitations of these studies with regard to the evidence of the hypothesized relationship between vitamin E and cardiovascular diseases.
authors.affiliation: Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrucke, Nuthetal, Germany. gonzalez@mail.dife.de
authors.forename: Zorabel
authors.initials: Z
authors.lastname: Cordero
authors.forename: Dagmar
authors.initials: D
authors.lastname: Drogan
authors.forename: Cornelia
authors.initials: C
authors.lastname: Weikert
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
mesh_terms: D000975:Antioxidants / Q000494:pharmacology*; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control*; D004032:Diet; D014943:Global Health; D006801:Humans; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D014810:Vitamin E