Total synthesis of (+/-)-galanthamine via a C3-selective Stille coupling and IMDA cycloaddition cascade of 3,5-dibromo-2-pyrone.
A new efficient synthetic route to (+/-)-galanthamine was devised by using a tandem C3-selective Stille coupling-IMDA cascade of 3,5-dibromo-2-pyrone as a key strategy.
Chang
Jay Hyok
JH
Department of Chemistry, Hanyang University, Seoul 133-791, Korea.
Kang
Ho-Ung
HU
Jung
In-Hak
IH
Cho
Cheon-Gyu
CG
D003500:Cyclization; D005702:Galantamine / Q000138:chemical synthesis* / Q000737:chemistry; D011753:Pyrones / Q000737:chemistry*; D013237:Stereoisomerism
C450850:3,5-dibromo-2-pyrone; D011753:Pyrones; D005702:Galantamine