title: Increased prevalence of the metabolic syndrome in patients with psoriatic arthritis.
abstract: OBJECTIVE
  Psoriasis (PsO) is a common chronic T cell-mediated inflammatory disorder traditionally thought to manifest in the skin and joints (psoriatic arthritis, PsA). Recently, it has been shown that these patients have an increased risk for myocardial infarction and this was greater with increasing severity of psoriasis. Patients with psoriasis have reported to have cardiometabolic disturbances including obesity, insulin resistance, and dyslipidemia. This constellation of risk factors, referred to as the metabolic syndrome, increases the risk for atherosclerotic cardiovascular disease (ASCVD) and type 2 diabetes mellitus. The aim of this study was to determine the prevalence of metabolic syndrome in PsA.
  
  
  METHODS
  In our study, we examined the records of 105 patients with PsA to determine the prevalence of metabolic syndrome in PsA. This was a retrospective analysis of the Sacramento Veterans Affairs database.
  
  
  RESULTS
  Our results demonstrated an increased prevalence of the metabolic syndrome in patients with PsA (61/105 patients or 58.1%) compared to the 35.2 % reported for the Third National Health and Nutrition Examination Survery (NHANES III) data.
  
  
  CONCLUSIONS
  Thus, patients with PsA have a very high prevalence of metabolic syndrome, which predisposes them to an increased risk of both diabetes and ASCVD.
authors.affiliation: VA Medical Center, Mather, California, USA.
authors.forename: Smriti K
authors.initials: SK
authors.lastname: Raychaudhuri
authors.forename: Sidhartha
authors.initials: S
authors.lastname: Chatterjee
authors.forename: Caroline
authors.initials: C
authors.lastname: Nguyen
authors.forename: Manpreet
authors.initials: M
authors.lastname: Kaur
authors.forename: Ishwarlal
authors.initials: I
authors.lastname: Jialal
authors.forename: Siba P
authors.initials: SP
authors.lastname: Raychaudhuri
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015535:Arthritis, Psoriatic / Q000453:epidemiology* / Q000209:etiology; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood; D014481:United States / Q000453:epidemiology; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D014280:Triglycerides