title: A new paradigm for high-sensitivity 19F magnetic resonance imaging of perfluorooctylbromide.
abstract: In the present work, the NMR properties of perfluorooctylbromide are revisited to derive a high-sensitivity fluorine MRI strategy. It is shown that the harmful effects of J-coupling can be eliminated by carefully choosing the bandwidth of the 180 degrees pulses in a spin-echo sequence. The T(2) of the CF(3) resonance of the molecule is measured using a multispin-echo sequence and shown to dramatically depend on the interpulse delay. Following these observations, an optimized multispin-echo imaging sequence is derived and compared with short TE/pulse repetition time gradient echo and chemical shift imaging sequences. The unparalleled sensitivity yielded by the multispin-echo sequence is promising for future applications, in particular for targeted contrast agents such as perfluorooctylbromide nanoparticles.
authors.affiliation: Neurospin, I2BM, Commissariat à l'Energie Atomique, Gif-sur-Yvette, France.
authors.forename: Céline
authors.initials: C
authors.lastname: Giraudeau
authors.forename: Julien
authors.initials: J
authors.lastname: Flament
authors.forename: Benjamin
authors.initials: B
authors.lastname: Marty
authors.forename: Fawzi
authors.initials: F
authors.lastname: Boumezbeur
authors.forename: Sébastien
authors.initials: S
authors.lastname: Mériaux
authors.forename: Caroline
authors.initials: C
authors.lastname: Robic
authors.forename: Marc
authors.initials: M
authors.lastname: Port
authors.forename: Nicolas
authors.initials: N
authors.lastname: Tsapis
authors.forename: Elias
authors.initials: E
authors.lastname: Fattal
authors.forename: Eric
authors.initials: E
authors.lastname: Giacomini
authors.forename: Franck
authors.initials: F
authors.lastname: Lethimonnier
authors.forename: Denis
authors.initials: D
authors.lastname: Le Bihan
authors.forename: Julien
authors.initials: J
authors.lastname: Valette
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D005461:Fluorine; D005466:Fluorocarbons / Q000737:chemistry*; D006842:Hydrocarbons, Brominated; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D005461:Fluorine; C003072:perflubron