title: Densitometric and geometric measurement of the proximal femur in elderly women with and without osteoporotic vertebral fractures by volumetric quantitative multi-slice CT.
abstract: There is a lack of research on volumetric multi-slice CT (MSCT) application in hip densitometric assessment and geometric measures in elderly women with osteoporotic vertebral fractures. A total of 237 elderly women were divided into three groups based on BMD values of the lumbar spine (AP-SPINE) and/or the femoral neck (NECK) by dual energy X-ray absorptiometry (DXA): osteoporosis with (OP_FX, 53 cases) or without vertebral fracture (OP_NONFX, 94 cases), or normal BMD (CONTROL, 90 cases). Volumetric BMD of trabecular bone (TRAB), integral bone (INTGL) and cortical bone (CORT) with neck axis length (NAL) and minimum cross-section area (mCSA) measures of the left femoral neck were calculated, respectively, by using OsteoCAD software based on MSCT scans of the abdominal-pelvic region of all participants, then the index of femoral neck strength (FNSI) was estimated. The values of TRAB, CORT and INTGL of OP_FX were significantly lower than those of OP_NONFX, with the decrease in 6.8-21.8%, as well as being lower than those in CONTROL, whereas no significant differences in the values of AP-SPINE and NECK were found between OP_FX and OP_NONFX. No significant difference of the value of mCSA was found among these three groups. The NAL value of OP_NONFX was larger than that of CONTROL. FNSI of femoral neck in OP_FX (0.42 ± 0.15 g(2)/cm(4)) was significantly lower than OP_NONFX (0.50 ± 0.14 g(2)/cm(4)) (p < 0.05). vQCT measurement seemed to be more effective than DXA in evaluating hip densitometric changes and discriminating osteoporotic elderly subjects with fractured vertebrae from the non-fractured in a group of Chinese women.
authors.affiliation: Medical Image Institute of Tianjin, 24 Fukang Road, Tianjin, People's Republic of China. cjr.wushengyong@vip.163.com
authors.forename: Sheng-yong
authors.initials: SY
authors.lastname: Wu
authors.forename: Ji
authors.initials: J
authors.lastname: Qi
authors.forename: Ying
authors.initials: Y
authors.lastname: Lu
authors.forename: Jing
authors.initials: J
authors.lastname: Lan
authors.forename: Jin-chao
authors.initials: JC
authors.lastname: Yu
authors.forename: Lian-qing
authors.initials: LQ
authors.lastname: Wen
authors.forename: Zhuo-li
authors.initials: ZL
authors.lastname: Zhang
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D001837:Body Weights and Measures; D015519:Bone Density; D002681:China; D005260:Female; D005269:Femur / Q000000981:diagnostic imaging*; D005272:Femur Neck / Q000000981:diagnostic imaging; D006620:Hip Fractures / Q000209:etiology; D006801:Humans; D021621:Imaging, Three-Dimensional; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000503:physiopathology*; D058866:Osteoporotic Fractures / Q000503:physiopathology*; D012720:Severity of Illness Index; D016103:Spinal Fractures / Q000209:etiology*; D014057:Tomography, X-Ray Computed / Q000379:methods*