Toxicokinetics of a dipyridamole (Persantin) intoxication: case report.
We report a case of a 51-year-old woman who was admitted to the hospital after ingestion of large doses of dipyridamole (12 g), temazepam (1 g) and oxazepam (0.2 g) with suicidal intent. The highest dipyridamole concentration that was measured in serum was 9.2 mg/L, which was paralleled by impaired platelet activation. For temazepam and oxazepam, peak serum concentrations were 8.5 and 1.3 mg/L, respectively. The patient was treated with activated charcoal, magnesium sulfate and aminophylline and could be discharged in good physical condition within 17 hours. This is the first report that provides toxicokinetic data and a corresponding pharmacodynamic effect after an intoxication with dipyridamole.
Lagas
Jurjen S
JS
Department of Pharmacy & Pharmacology, Slotervaart Hospital, Louwesweg 6, Amsterdam, The Netherlands. jurjen.lagas@slz.nl
Wilhelm
Abraham J
AJ
Vos
René M
RM
van den Dool
Erik-Jan
EJ
van der Heide
Yvonne
Y
Huissoon
Sandra
S
Beijnen
Jos H
JH
Brandjes
Desiderius P M
DP
D014151:Anti-Anxiety Agents / Q000506:poisoning; D004176:Dipyridamole / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010076:Oxazepam / Q000506:poisoning; D010975:Platelet Aggregation Inhibitors / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning*; D013406:Suicide, Attempted; D013693:Temazepam / Q000506:poisoning
D014151:Anti-Anxiety Agents; D010975:Platelet Aggregation Inhibitors; D004176:Dipyridamole; D010076:Oxazepam; D013693:Temazepam