The expression of EFEMP1 in cervical carcinoma and its relationship with prognosis.
OBJECTIVE
The study was to explore the role of EFEMP1 protein in angiogenesis and its relationship with prognosis of cervical carcinoma.


METHODS
EFEMP1 expression was evaluated by immunohistochemistry. The microvascular density (MVD) was detected with CD34 staining, and VEGF mRNA expression was evaluated by hybridization in situ. The associations of EFEMP1 with clinicopathologic characteristics, MVD, VEGF mRNA and overall survival were studied.


RESULTS
EFEMP1 expression was positively correlated with MVD and VEGF mRNA, and its overexpression was found to be significantly associated with lymph node metastasis, vascular invasion and poor survival. Multivariate analysis showed that EFEMP1 overexpression was independently related to poor prognosis of cervical cancer.


CONCLUSIONS
EFEMP1 promotes angiogenesis and associates with lymph node metastasis, vascular invasion and poor prognosis of cervical carcinoma. The current study shows that EFEMP1 may be a useful prognostic factor for patients with cervical carcinoma.
En-lin
Song
S
Biomedical Engineering Center, Department of Anatomy, the Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.
Sheng-guo
Chen
C
Hua-qiao
Wang
W
D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis / Q000096:biosynthesis; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis / Q000235:genetics; D055815:Young Adult
D018952:Antigens, CD34; C119630:EFEMP1 protein, human; D016326:Extracellular Matrix Proteins; D012333:RNA, Messenger; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A