Visceral fat decreased by long-term interdisciplinary lifestyle therapy correlated positively with interleukin-6 and tumor necrosis factor-α and negatively with adiponectin levels in obese adolescents.
The purpose of this study was to assess the level of cytokine expression in correlation with visceral and subcutaneous fat in obese adolescents admitted to long-term interdisciplinary weight loss therapy. The study was a longitudinal clinical intervention of interdisciplinary therapy. Adolescents (18, aged 15-19 years) with body mass indexes greater than the 95th percentile were admitted and evaluated at baseline and again after 1 year of interdisciplinary therapy. Visceral and subcutaneous fat was analyzed by ultrasonography. Blood samples were collected to analyze tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10), and adiponectin concentrations that were measured by enzyme-linked immunosorbent assay. The most important finding in the present investigation is that the long-term interdisciplinary lifestyle therapy decreased visceral fat. Positive correlations between IL-6 levels and visceral fat (r = 0.42, P < .02) and TNF-α levels and visceral fat (r = 0.40, P < .05) were observed. Negative correlations between TNF-α levels and subcutaneous fat (r = -0.46, P < .01) and adiponectin levels and subcutaneous fat (r = -0.43, P < .03) were also observed. In addition, we found a positive correlation between TNF-α levels and the visceral to subcutaneous fat ratio (r = 0.42, P < .02) and a negative correlation between adiponectin level and the visceral to subcutaneous fat ratio (r = -0.69, P < .001). Despite the limitation of sample size, our results indicate that the observed massive weight loss (mainly visceral fat) was highly correlated with a decreased inflammatory state, suggesting that the interdisciplinary therapy was effective in decreasing inflammatory markers.
Lira
Fábio Santos
FS
Postgraduate Program of Nutrition, Federal University of São Paulo-UNIFESP, São Paulo/SP 04020-060, Brazil. fabioslira@gmail.com
Rosa
Jose Cesar
JC
Dos Santos
Ronaldo Vagner
RV
Venancio
Daniel Paulino
DP
Carnier
June
J
Sanches
Priscila de Lima
Pde L
do Nascimento
Claudia Maria Oller
CM
de Piano
Aline
A
Tock
Lian
L
Tufik
Sergio
S
de Mello
Marco Túlio
MT
Dâmaso
Ana R
AR
Oyama
Lila Missae
LM
D052242:Adiponectin / Q000097:blood; D000293:Adolescent; D001521:Behavior Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000378:metabolism*; D008137:Longitudinal Studies; D008297:Male; D009765:Obesity / Q000097:blood / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000628:therapy*; D018709:Statistics, Nonparametric; D050151:Subcutaneous Fat / Q000000981:diagnostic imaging / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D014463:Ultrasonography; D015431:Weight Loss; D055815:Young Adult
D052242:Adiponectin; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10