title: Formulation and evaluation of Cetirizine dihydrochloride orodispersible tablet.
abstract: Cetirizine orodispersible tablets were prepared to achieve quick onset of action and for maximum bioavailability. Tablets were prepared using cetirizine along with camphor and mannitol in the proportion of 1:1:1, 1:1:3, and 1:1:6. The flow property of granules was found to be good for the formulation CZ2 (1:1:3). The hardness and friability of all the formulations were found to be within the standard limit for orodispersible tablets. Disintegration time was found to be rapid in formulation CZ2 (1:1:3).The in vitro dissolution time was found to be 100% in 11 minutes for the formulation CZ2 (1:1:3).
authors.affiliation: Department of Pharmaceutics, PSG College of Pharmacy, Coimbatore - 641004. subbu3j@gmail.com
authors.forename: S
authors.initials: S
authors.lastname: Subramanian
authors.forename: V
authors.initials: V
authors.lastname: Sankar
authors.forename: Asha Asokan
authors.initials: AA
authors.lastname: Manakadan
authors.forename: Sareena
authors.initials: S
authors.lastname: Ismail
authors.forename: G
authors.initials: G
authors.lastname: Andhuvan
mesh_terms: D000284:Administration, Oral; D002164:Camphor / Q000737:chemistry; D017332:Cetirizine / Q000008:administration & dosage* / Q000737:chemistry; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D019245:Compressive Strength; D004339:Drug Compounding / Q000379:methods; D005079:Excipients / Q000737:chemistry; D006244:Hardness; D066298:In Vitro Techniques; D008353:Mannitol / Q000737:chemistry; D012995:Solubility; D013607:Tablets / Q000008:administration & dosage* / Q000737:chemistry*
chemical_list: D005079:Excipients; D013607:Tablets; D008353:Mannitol; D002164:Camphor; D017332:Cetirizine