Radiotherapy: Neurocognitive considerations in the treatment of brain metastases.
The results of a randomized, controlled trial investigating the neurocognitive effects of stereotactic radiosurgery (SRS), with or without whole-brain radiation therapy (WBRT), to treat brain metastases demonstrated a significant reduction in learning and memory, associated with the addition of WBRT to SRS. the results indicate that SRS monotherapy is an effective and safe initial management strategy for brain metastases.
Marko
Nicholas F
NF
Department of Neurosurgery, The Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, ND-40, 9500 Euclid Avenue, Cleveland, OH 44195, USA. markon@ccf.org
Weil
Robert J
RJ
D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D003072:Cognition Disorders; D018450:Disease Progression; D006801:Humans; D017567:Karnofsky Performance Status; D007858:Learning; D007859:Learning Disabilities; D008568:Memory; D008569:Memory Disorders; D011788:Quality of Life; D016634:Radiosurgery; D011878:Radiotherapy; D016896:Treatment Outcome