Novel self-nanoemulsifying drug delivery system for enhanced solubility and dissolution of lutein.
Self-nanoemulsifying drug delivery system (SNEDDS) containing oil (Phosal 53 MCT), surfactant (Labrasol), and cosurfactant (Transcutol-HP or Lutrol-E400) was prepared to enhance solubility and dissolution of lutein. Ternary phase diagram of the SNEDDS was constructed to identify the self-emulsifying regions following which the percentage of oil, surfactant, and cosurfactant in the SNEDDS were optimized in terms of emulsification time and mean emulsion droplet size. The optimized SNEDDS consists of 25% oil, 60% surfactant, and 15% cosurfactant. When measured using USP XXIII dissolution apparatus II, the emulsification time of the SNEDDS prepared with Transcutol-HP as cosurfactant was less than 20 sec, and it was 20-30 sec in the SNEDDS prepared with Lutrol-E400. Mean emulsion droplet size was slightly smaller when Transcutol-HP was used as cosurfactant (80 +/- 6 nm), compared to when Lutrol- E400 was used (93 +/- 6 nm). Dissolution of lutein from the solid SNEDDS (physical mixture of the optimized SNEDDS and Aerosil 200) took place immediately (less than 5 min) in distilled water, and, once dissolved, no precipitation or aggregation of the drug were observed. In contrast, no drug was released from lutein powder or from the commercial product (Eyelac(R)) until 3 h of the study duration.
Yoo
Jeoung Hee
JH
College of Pharmacy, Chungbuk National University, Cheongju, 361-763, Korea.
Shanmugam
Srinivasan
S
Thapa
Pritam
P
Lee
Eung-Seok
ES
Balakrishnan
Prabagar
P
Baskaran
Rengarajan
R
Yoon
Sang-Kwon
SK
Choi
Han-Gon
HG
Yong
Chul Soon
CS
Yoo
Bong Kyu
BK
Han
Kun
K
D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D004339:Drug Compounding; D004655:Emulsions; D005026:Ethylene Glycols / Q000737:chemistry; D005989:Glycerides; D007700:Kinetics; D014975:Lutein / Q000737:chemistry*; D053758:Nanoparticles; D009930:Organic Chemicals / Q000737:chemistry; D010316:Particle Size; D010743:Phospholipids / Q000737:chemistry; D010938:Plant Oils / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D012715:Sesame Oil / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry; D012995:Solubility; D013024:Soybean Oil / Q000737:chemistry; D000074242:Sunflower Oil; D013501:Surface-Active Agents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods
D004337:Drug Carriers; D004655:Emulsions; D005026:Ethylene Glycols; D005989:Glycerides; C506200:Lutrol; D009930:Organic Chemicals; D010743:Phospholipids; D010938:Plant Oils; D000074242:Sunflower Oil; D013501:Surface-Active Agents; C440220:Labrasol; D011092:Polyethylene Glycols; D012822:Silicon Dioxide; D013024:Soybean Oil; D012715:Sesame Oil; C010111:carbitol; D014975:Lutein