title: Fatal outcome of spontaneous cerebral and intraventricular hemorrhage in a child with idiopathic thrombocytopenic purpura (ITP)--case report.
abstract: BACKGROUND
  Idiopathic thrombocytopenic purpura (ITP) is the most prevalent acquired hemorrhagic diathesis in children characterised by antibody-mediated destruction of platelets. ITP is generally a self-limiting benign disorder but despite this good prognosis, ITP carries the risk of severe bleeding (mainly intracranial) that may threaten the child's life.
  
  
  METHODS
  We describe a case of a 5-year-old girl with idiopathic thrombocytopenic purpura in the course of EBV infection with massive cerebral and intraventricular hemorrhage and fatal outcome.
  
  
  CONCLUSIONS
  This extremely rare case of intracranial haemorrhage in a child with ITP coexisting with EBV infection (a likely additional risk factor for hemorrhage) deserves attention considering the fatal outcome despite intensive treatment.
authors.affiliation: Klinika Pediatrii, Hematologii i Onkologui Dzieciecej Pomorskiej Akademii Medycznej w Szczecinie ul. Unii Lubelskiej 1,71-252 Szczecin
authors.forename: Andrzej
authors.initials: A
authors.lastname: Brodkiewicz
authors.forename: Jarosław
authors.initials: J
authors.lastname: Peregud-Pogorzelski
authors.forename: Elwira
authors.initials: E
authors.lastname: Szychot
authors.forename: Beata
authors.initials: B
authors.lastname: Badowicz
authors.forename: Cezary
authors.initials: C
authors.lastname: Pakulski
authors.forename: Hanna
authors.initials: H
authors.lastname: Marciniak
mesh_terms: D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000209:etiology*; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications*