A copper(II)-mediated regioselective cyclization-acetoxylation of 6,8-dien-1-ones for the synthesis of functionalized cyclopentanes.
This paper describes a copper(II) acetate-mediated cyclization-acetoxylation of 6,8-dien-1-ones in the presence of sodium acetate as base. A variety of functionalized cyclopentanes containing synthetic useful allylic alcohol moieties with three contiguous stereogenic centers were synthesized in moderate to good yields with moderate to high regioselectivities.
Wang
Yazhou
Y
Beijing National Laboratory of Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
Du
Haifeng
H
D000466:Alkadienes / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000466:Alkadienes; D003517:Cyclopentanes; D009942:Organometallic Compounds; D003300:Copper