title: Highly chemo- and enantioselective synthesis of 3-allyl-3-aryl oxindoles via the direct palladium-catalyzed alpha-arylation of amides.
abstract: A new NHC x Pd-catalyzed asymmetric alpha-arylation of amides is reported that gives direct access to synthetically valuable, allylated oxindoles with quaternary carbon centers. The reaction is made possible by the introduction of a new chiral NHC ligand. The palladium complexes derived therefrom combine excellent reactivity with high chemo- and enantioselectivity for the title transformation.
authors.affiliation: Organic Chemistry Institute, University of Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.
authors.forename: Xinjun
authors.initials: X
authors.lastname: Luan
authors.forename: Linglin
authors.initials: L
authors.lastname: Wu
authors.forename: Emma
authors.initials: E
authors.lastname: Drinkel
authors.forename: Ronaldo
authors.initials: R
authors.lastname: Mariz
authors.forename: Michele
authors.initials: M
authors.lastname: Gatti
authors.forename: Reto
authors.initials: R
authors.lastname: Dorta
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D007211:Indoles; D010165:Palladium