Pregnancy increases the growth rates of World Health Organization grade II gliomas.
Twelve pregnancies in 11 adult women harboring World Health Organization (WHO) grade II gliomas (GIIGs) prior to pregnancy were reviewed to address whether pregnancy affects tumor growth using a quantitative approach of the radiological velocity of diametric expansion (VDE) on successive magnetic resonance images. VDE was significantly increased during pregnancy as compared to prepregnancy (p < 0.001) and to postdelivery (p = 0.012) periods. Pregnancy increases the radiological growth rates of GIIGs. An increase in seizure frequency was observed concomitantly in 40% of cases and further oncological treatment was started after delivery in 25% of cases.
Pallud
Johan
J
Department of Neurosurgery, Sainte-Anne Hospital, 1 rue Cabanis, 75674 Paris Cedex 14, France. johanpallud@hotmail.com
Mandonnet
Emmanuel
E
Deroulers
Christophe
C
Fontaine
Denys
D
Badoual
Mathilde
M
Capelle
Laurent
L
Guillet-May
Frédérique
F
Page
Philippe
P
Peruzzi
Philippe
P
Jouanneau
Emmanuel
E
Frenay
Marc
M
Cartalat-Carel
Stéphanie
S
Duffau
Hugues
H
Taillandier
Luc
L
D000328:Adult; D001254:Astrocytoma / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D001932:Brain Neoplasms / Q000145:classification / Q000473:pathology* / Q000503:physiopathology; D049109:Cell Proliferation; D018450:Disease Progression; D005260:Female; D005910:Glioma / Q000145:classification / Q000473:pathology* / Q000503:physiopathology; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009837:Oligodendroglioma / Q000473:pathology / Q000503:physiopathology; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology* / Q000503:physiopathology; D012640:Seizures / Q000209:etiology / Q000503:physiopathology; D014944:World Health Organization; D055815:Young Adult
D012739:Gonadal Steroid Hormones; D013006:Growth Hormone