title: Mitochondria-targeted plastoquinone derivative SkQ1 increases early reproduction of Drosophila melanogaster at the cost of early survival.
abstract: It was previously found that 20 pM SkQ1 (10-(6'-plastoquinonyl) decyltriphenylphosphonium) solution increased lifespan of virgin females and males of the fruit fly Drosophila melanogaster with maximal and highly reproducible effect on early survival of females. In this paper we demonstrate that SkQ1 solution of the same concentration does not increase lifespan of mated females and males, early effect on female survival being absent, whereas early fertility and the total number of progeny are elevated in treated flies. Increase in fertility observed in young mated females instead of increase of survival typical for young virgin females might illustrate the trade-off between the fly's lifespan and reproduction.
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, pl. Kurchatova 2, Moscow, Russia.
authors.forename: E A
authors.initials: EA
authors.lastname: Tsybul'ko
authors.forename: N V
authors.initials: NV
authors.lastname: Roshina
authors.forename: O Yu
authors.initials: OY
authors.lastname: Rybina
authors.forename: E G
authors.initials: EG
authors.lastname: Pasyukova
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000502:physiology*; D005260:Female; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D010971:Plastoquinone / Q000378:metabolism*; D012098:Reproduction / Q000502:physiology*
chemical_list: D010971:Plastoquinone