title: Chemokine decoy receptors: structure-function and biological properties.
abstract: Chemokines induce cell migration through the activation of a distinct family of structurally related heterotrimeric G protein-coupled receptors (GPCR). Over the last few years, several receptors in this family that recognize chemokines but do not induce cell migration have been identified. These "atypical" chemokine receptors are unable to activate transduction events that lead directly to cell migration, but appear nonetheless to play a nonredundant role in the control of leukocyte recruitment at inflammatory sites and in tumors by shaping the chemoattractant gradient, either by removing, transporting, or concentrating their cognate ligands.
authors.affiliation: Department of Translational Medicine, University of Milan, 20089 Rozzano, Milan, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Bonecchi
authors.forename: Benedetta
authors.initials: B
authors.lastname: Savino
authors.forename: Elena M
authors.initials: EM
authors.lastname: Borroni
authors.forename: Alberto
authors.initials: A
authors.lastname: Mantovani
authors.forename: Massimo
authors.initials: M
authors.lastname: Locati
mesh_terms: D000818:Animals; D002465:Cell Movement; D018925:Chemokines / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D007962:Leukocytes / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology; D019707:Receptors, Chemokine / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D013329:Structure-Activity Relationship
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine