title: Outcome of hematopoietic stem cell transplant as salvage therapy for Hodgkin's lymphoma in adolescents and young adults at a single institution.
abstract: For patients with relapsed Hodgkin's lymphoma (HL), high dose chemotherapy with stem cell rescue (HDCT-SCT) may improve survival over chemotherapy alone. We assessed the outcomes of HDCT-SCT in 37 consecutive adolescent and young adult patients with relapsed HL whose malignancy was categorized based on sensitivity to chemotherapy. We determined whether current outcomes supported the use of HDCT-SCT in all of our patients or just those patients with lower-risk characteristics such as chemosensitivity. With a median follow-up of 6.5 years, the 2-year overall survival (OS) was 89% (95% CI: 62-97%) for the chemosensitive patients (n = 21), whereas for patients with resistant disease (n = 16), OS was 53% (95% CI: 25-74%). Both autologous and allogeneic transplants were well tolerated, with 100-day treatment-related mortality under 10%. Our data show encouraging outcomes for patients with chemosensitive relapsed HL who receive hematopoietic stem cell transplant (HSCT) and support the value of the procedure even when the disease is chemoresistant.
authors.affiliation: Center for Cell and Gene Therapy, Houston, TX 77030, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Shafer
authors.forename: H E
authors.initials: HE
authors.lastname: Heslop
authors.forename: M K
authors.initials: MK
authors.lastname: Brenner
authors.forename: G
authors.initials: G
authors.lastname: Carrum
authors.forename: M F
authors.initials: MF
authors.lastname: Wu
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: N
authors.initials: N
authors.lastname: Ahmed
authors.forename: S
authors.initials: S
authors.lastname: Gottschalk
authors.forename: R
authors.initials: R
authors.lastname: Kamble
authors.forename: K S
authors.initials: KS
authors.lastname: Leung
authors.forename: G D
authors.initials: GD
authors.lastname: Myers
authors.forename: C M
authors.initials: CM
authors.lastname: Bollard
authors.forename: R A
authors.initials: RA
authors.lastname: Krance
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006689:Hodgkin Disease / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D006801:Humans; D011379:Prognosis; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000009:adverse effects; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult