title: [Effect of the new propofol target controlled infusion system in children undergoing high ligation of hernial sac].
abstract: OBJECTIVE
  To discuss the effect of the new target controlled infusion (TCI) system in Chinese children undergoing minor operation and compared with TCI system with Marsh parameters.
  
  
  METHODS
  Ninety ASA I, aged 3 - 5 yrs children undergoing elective unilateral high ligation of hernial sac under general anesthesia were randomly divided into group L (n = 45) and group M (n = 45) 2 groups. All subjects were unpremedicated. Systolic blood pressure (SBP), diastolic blood pressure (DBP), ECG, SpO2 and BIS were monitored. Patients of Group L and group M were anesthetized with propofol by Lian propofol TCI system and Marsh system respectively, combined with regional block. The target plasma concentration of TCI system was set at 6 microg/ml initially and up-regulated 1 microg/ml gradually if obvious body movement occurred while skin incision. If the target plasma concentration up to 8 microg/ml but there still had body movement, the TCI venous anesthesia was replaced by inhaled anesthesia. HR, RR, SBP, DBP and BIS were recorded in time points of baseline (T(0)), after the induction (T(1)), skin incision (T(2)), 3, 5 min after skin incision (T(3), T(4)), the end of operation (T(5)). Complications, the awakening time and the number of cases which anesthetized with different propofol plasma concentrations or inhaled anesthesia were recorded respectively as well.
  
  
  RESULTS
  The number of cases which completed the operation under TCI plasma concentration 6 microg/ml in group L were significantly more than those in group M (P < 0.01). There were significantly different of T(1)-T(4) values of HR, RR, SBP, DBP and BIS in group M (P < 0.05), but not in group L. Compared with group L, T(2)-T(4) values of HR, RR, SBP, DBP and BIS were higher in group M (P < 0.05 or 0.01). Complications were lower in group L than those in group M.
  
  
  CONCLUSIONS
  Compared with Marsh system, propofol 6 microg/ml plasma concentration with the new target controlled infusion system applied in Chinese children undergoing unilateral high ligation of hernial sac could maintain stable hemodynamics, less stress reaction and complications.
authors.affiliation: Department of Anesthesiology, The 2nd Affiliated Hospital of Wenzhou Medical College, Wenzhou 325027, China.
authors.forename: Hua-cheng
authors.initials: HC
authors.lastname: Liu
authors.forename: Hai-long
authors.initials: HL
authors.lastname: Song
authors.forename: Xi-xi
authors.initials: XX
authors.lastname: Huang
authors.forename: Zhi-lian
authors.initials: ZL
authors.lastname: Huang
authors.forename: Wang-ning
authors.initials: WN
authors.lastname: Shangguan
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Qing-quan
authors.initials: QQ
authors.lastname: Lian
mesh_terms: D002675:Child, Preschool; D016503:Drug Delivery Systems; D005260:Female; D006552:Hernia, Inguinal / Q000601:surgery*; D006801:Humans; D008297:Male; D015742:Propofol / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D015742:Propofol