title: The mean platelet volume in patients with non-dipper hypertension compared to dippers and normotensives.
abstract: OBJECTIVE
  Increased platelet activation plays an important role in the development of atherosclerosis. Mean platelet volume (MPV) is a determinant of platelet activation. In our study, we aimed to determine whether MPV levels are elevated in non-dipper patients compared with dippers and healthy controls. In addition, we tried to find out if MPV levels are correlated with blood pressure measurements in hypertensive patients.
  
  
  METHODS
  This cross-sectional study included 56 hypertensive patients; 27 age- and sex-matched healthy volunteers were enrolled to study as a control subjects. Ambulatory blood pressure monitoring was performed for all patients. Hypertensive patients were divided into two groups: 28 dipper patients (10 male, mean age 51 +/-8 years) and 28 non-dipper patients (11 male, mean age 53+/-10 years). MPV was measured in a blood sample collected in EDTA tubes and was also used for whole blood counts in all patients.
  
  
  RESULTS
  In non-dipper patients, 24-h systolic blood pressure (141.5+/-10.21 vs 132.3+/-7.7 mmHg, p<0.001), 24-h diastolic blood pressure (88.2+/-8.5 vs 81.0+/-8.2 mmHg, p<0.01) and 24-h average blood pressure (105.7+/-8.5 vs 97.7+/-7.4 mmHg, p<0.001) are significantly higher than dippers. Whereas daytime measurements were similar between dippers and non-dippers, there was a significant difference between each group during night-time measurements (night-time systolic 137.1 +/-11.0 vs 120.2+/-8.0 mmHg, p<0.001; night-time diastolic 85.3+/-8.0 vs 72.8+/-7.9 mmHg, p<0.001). Non-dipper patients (9.61 +/-0.42 fl) demonstrated higher levels of MPV compared with dippers (9.24+/-0.35 fl) and normotensives (8.87+/-0.33 fl) (p<0.001 and p<0.001, respectively). There was significant correlation between MPV and ambulatory diastolic and systolic blood pressure in non-dipper hypertensives.
  
  
  CONCLUSIONS
  Our results suggest that MPV, a determinant of platelet activation, has a positively correlation with blood pressure and elevated in non-dipper compared with dippers and controls. Increased platelet activation could contribute to increase the atherosclerotic risk in non-dipper patients compared with dippers.
authors.affiliation: Erciyes University, Department of Cardiology, Kayseri, Turkey. mtinanc@yahoo.com
authors.forename: Tugrul
authors.initials: T
authors.lastname: Inanc
authors.forename: Mehmet Gungor
authors.initials: MG
authors.lastname: Kaya
authors.forename: Mikail
authors.initials: M
authors.lastname: Yarlioglues
authors.forename: Idris
authors.initials: I
authors.lastname: Ardic
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Ozdogru
authors.forename: Ali
authors.initials: A
authors.lastname: Dogan
authors.forename: Nihat
authors.initials: N
authors.lastname: Kalay
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Gunturk
authors.forename: Ozgur
authors.initials: O
authors.lastname: Gunebakmaz
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Gul
authors.forename: Ramazan
authors.initials: R
authors.lastname: Topsakal
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use; D001792:Blood Platelets / Q000473:pathology*; D001794:Blood Pressure / Q000502:physiology; D018660:Blood Pressure Monitoring, Ambulatory; D016022:Case-Control Studies; D002940:Circadian Rhythm / Q000502:physiology; D003430:Cross-Sectional Studies; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010976:Platelet Count
chemical_list: D000959:Antihypertensive Agents