title: Metabolomic imaging for human prostate cancer detection.
abstract: As current radiological approaches cannot accurately localize prostate cancer in vivo, biopsies are conducted at random within prostates for patients at risk for prostate cancer, leading to high false-negative rates. Metabolomic imaging can map cancer-specific biomolecular profile values onto anatomical structures to direct biopsy. In this preliminary study, we evaluated five whole prostates removed during prostatectomy from biopsy-proven cancer patients on a 7-tesla human whole-body magnetic resonance scanner. Localized, multi-cross-sectional, multivoxel magnetic resonance spectra were used to construct a malignancy index based on prostate cancer metabolomic profiles obtained from previous intact tissue analyses with a 14-tesla spectrometer. This calculated malignancy index is linearly correlated with lesion size and demonstrates a 93 to 97% overall accuracy for detecting the presence of prostate cancer lesions, suggesting the potential clinical utility of this approach.
authors.affiliation: Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Chin-Lee
authors.initials: CL
authors.lastname: Wu
authors.forename: Kate W
authors.initials: KW
authors.lastname: Jordan
authors.forename: Eva M
authors.initials: EM
authors.lastname: Ratai
authors.forename: Jinhua
authors.initials: J
authors.lastname: Sheng
authors.forename: Christen B
authors.initials: CB
authors.lastname: Adkins
authors.forename: Elita M
authors.initials: EM
authors.lastname: Defeo
authors.forename: Bruce G
authors.initials: BG
authors.lastname: Jenkins
authors.forename: Leslie
authors.initials: L
authors.lastname: Ying
authors.forename: W Scott
authors.initials: WS
authors.lastname: McDougal
authors.forename: Leo L
authors.initials: LL
authors.lastname: Cheng
mesh_terms: D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D008297:Male; D055432:Metabolomics / Q000379:methods*; D008875:Middle Aged; D019047:Phantoms, Imaging; D025341:Principal Component Analysis; D011467:Prostate / Q000378:metabolism / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism*