An estimate of cancers attributable to occupational exposures in France.
OBJECTIVE
To perform a quantitative estimate of the proportion of cancers attributable to occupational exposures in France in 2000.


METHODS
Exposure data for established carcinogens were obtained from a 1994 survey and other sources. Relative risks for 23 exposure-cancer combinations were derived from meta-analyses and pooled analyses.


RESULTS
A total of 4335 cases of cancer among men (2.7% of all cancers) and 403 cases among women (0.3% of all cancers) were attributed to occupational exposures. Asbestos, polycyclic aromatic hydrocarbons, and chromium VI were the main occupational carcinogens in men, and asbestos and involuntary smoking were the main carcinogens in women. Corresponding proportions for cancer deaths were 4.0% and 0.6% in men and women, respectively. Lung cancer represented 75% of deaths attributable to occupational exposures.


CONCLUSIONS
Our estimates are comparable with those obtained for other countries in studies based on similar methodology.
Boffetta
Paolo
P
International Prevention Research Institute, Lyon, France.
Autier
Philippe
P
Boniol
Mathieu
M
Boyle
Peter
P
Hill
Catherine
C
Aurengo
André
A
Masse
Roland
R
Thé
Guy de
Gd
Valleron
Alain-Jacques
AJ
Monier
Roger
R
Tubiana
Maurice
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D001194:Asbestos / Q000633:toxicity; D002273:Carcinogens / Q000633:toxicity*; D002857:Chromium / Q000633:toxicity; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology*; D009784:Occupational Diseases / Q000139:chemically induced* / Q000453:epidemiology*; D016273:Occupational Exposure; D011084:Polycyclic Aromatic Hydrocarbons / Q000633:toxicity; D012907:Smoking / Q000009:adverse effects; D055815:Young Adult
D002273:Carcinogens; D011084:Polycyclic Aromatic Hydrocarbons; D002857:Chromium; D001194:Asbestos