title: Prospects for new antimicrobials based on N,N-dimethylbiguanide complexes as effective agents on both planktonic and adhered microbial strains.
abstract: Metal-free N,N-dimethylbiguanidium acetate and novel complexes M(DMBG)(2)(CH(3)COO)(2).nH(2)O (M: Mn(II), Ni(II), Cu(II) and Zn(II)) were screened for their antimicrobial properties against Gram-positive (Bacillus subtilis, Listeria monocytogenes, Staphylococcus aureus), Gram-negative (Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa) bacteria and fungal (Candida albicans) strains. The ability of compounds to inhibit the microbial adherence ability to the inert substratum as well as their cytotoxicity was also assessed. Our results are demonstrating that some of the tested compounds are exhibiting potent antimicrobial activity accompanied by low cytotoxicity on HeLa cells. The complexes were characterized using microanalytical, IR, EPR, (1)H NMR as well as UV-vis methods. The redox behaviour of complexes was investigated by cyclic voltammetry. The new derivative (HDMBG)(CH(3)COO) crystallizes in the monoclinic P2(1)/n space group as X-ray single-crystal data indicate.
authors.affiliation: Department of Inorganic Chemistry, University of Bucharest, 90-92 Panduri St., 050663 Bucharest, Romania. rodica_m_olar@yahoo.com
authors.forename: Rodica
authors.initials: R
authors.lastname: Olar
authors.forename: Mihaela
authors.initials: M
authors.lastname: Badea
authors.forename: Dana
authors.initials: D
authors.lastname: Marinescu
authors.forename: Carmen-Mariana
authors.initials: CM
authors.lastname: Chifiriuc
authors.forename: Coralia
authors.initials: C
authors.lastname: Bleotu
authors.forename: Maria Nicoleta
authors.initials: MN
authors.lastname: Grecu
authors.forename: Emilia Elena
authors.initials: EE
authors.lastname: Iorgulescu
authors.forename: Marcela
authors.initials: M
authors.lastname: Bucur
authors.forename: Veronica
authors.initials: V
authors.lastname: Lazar
authors.forename: Adriana
authors.initials: A
authors.lastname: Finaru
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001422:Bacterial Adhesion / Q000187:drug effects*; D018441:Biofilms / Q000187:drug effects; D018360:Crystallography, X-Ray; D004563:Electrochemistry; D005658:Fungi / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D008280:Magnetics; D008687:Metformin / Q000737:chemistry* / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010933:Plankton / Q000187:drug effects*; D013057:Spectrum Analysis
chemical_list: D000890:Anti-Infective Agents; D008687:Metformin