title: Mango extracts and the mango component mangiferin promote endothelial cell migration.
abstract: This study tested the hypothesis that mango extracts contain bioactive molecules capable of modulating endothelial cell migration, an essential step in the formation of new blood vessels or angiogenesis. The formation of new blood vessels is an important therapeutic target for diseases such as limb ischemia, coronary infarction or stroke. We examined the effect of mango peel and flesh extracts as well as the individual polyphenolic molecules, mangiferin and quercetin, on bovine aortic cell migration using a modified Boyden chamber assay. Our results show that mangiferin, and extracts rich in mangiferin, increase endothelial cell migration. The dose-effect relationship for various extracts further suggests that this action of mangiferin is modulated by other components present in the extracts. The promigratory effect of mango extracts or mangiferin was unrelated to an effect on cell proliferation, and did not involve a change in the production of matrix metalloprotease-2 or -9 by the endothelial cells. Taken together, these results suggest that mangiferin present in mango extracts may have health promoting effects in diseases related to the impaired formation of new blood vessels.
authors.affiliation: School of Pharmacy, University of Queensland, Woolloongabba, Queensland, Australia.
authors.forename: Noor Huda
authors.initials: NH
authors.lastname: Daud
authors.forename: Cho Sanda
authors.initials: CS
authors.lastname: Aung
authors.forename: Amitha K
authors.initials: AK
authors.lastname: Hewavitharana
authors.forename: Ashley S
authors.initials: AS
authors.lastname: Wilkinson
authors.forename: Jean-Thomas
authors.initials: JT
authors.lastname: Pierson
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Roberts-Thomson
authors.forename: P Nicholas
authors.initials: PN
authors.lastname: Shaw
authors.forename: Gregory R
authors.initials: GR
authors.lastname: Monteith
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Gidley
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Parat
mesh_terms: D000818:Animals; D002417:Cattle; D002465:Cell Movement / Q000187:drug effects*; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D031022:Mangifera / Q000737:chemistry*; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D053719:Tandem Mass Spectrometry; D044004:Xanthones / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D044004:Xanthones; C013592:mangiferin