Folate conjugated poly(ester amine) for lung cancer therapy.
Folate conjugated poly(ester amine) (PEA) was prepared by reaction of folic acid with PEAs based on polycaprolactone (PCL) and low molecular weight polyethylenimine (LMW-PEI) with PEG as a linker. This novel gene carrier showed excellent physicochemical properties and relatively low cytotoxicity compared with PEI 25K. It showed excellent transfection efficiency through folate receptor mediated endocytosis.
Arote
Rohidas B
RB
School of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea.
Yoon
Mi-Kyong
MK
Kim
Tae-Hee
TH
Jere
Dhananjay
D
Jiang
Hu-Lin
HL
Kim
You-Kyoung
YK
Park
In-Kyu
IK
Cho
Chong-Su
CS
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005492:Folic Acid / Q000008:administration & dosage* / Q000737:chemistry*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D050997:Nanomedicine / Q000379:methods*; D011091:Polyesters / Q000737:chemistry*; D013499:Surface Properties
D000970:Antineoplastic Agents; D046911:Macromolecular Substances; D053769:Nanocapsules; D011091:Polyesters; C016240:polycaprolactone; D005492:Folic Acid