title: What variables were associated with the inducibility of ventricular fibrillation during electrophysiologic stimulation test in patients without apparent organic heart disease?
abstract: OBJECTIVE
  The purpose of our study was to determine what variables were associated with ventricular fibrillation (VF) induced during electrophysiological stimulation test in patients without apparent organic heart disease.
  
  
  METHODS
  Our study evaluated 77 patients (51+/-15 years) who underwent electrophysiological stimulation test, signal averaging, and Na+ channel-blocker challenge test (pilsicainide test). The subjects were divided into two groups, the Brugada group and non-Brugada group. Further, the patients were divided into three subgroups on the base of symptoms (8, 7 symptomatic; 9, 13 syncope; 28, 12 asymptomatic group; in the Brugada and non-Brugada groups, respectively). Multivariate analyses evaluated the association between baseline clinical factors and the induction of VF.
  
  
  RESULTS
  The inducibility of VF was significantly (p<0.0001) higher in the Brugada group (n=33, 73%) than the non-Brugada group (n=4, 13%). The multivariate analysis demonstrated that symptoms (odds ratio (OR) 31.6; 95% confidence interval (CI): 2.3-430.6; p<0.01), type 1 electrocardiogram after pilsicainide test (OR 21.3; CI: 1.7-272.2; p<0.02), and syncope (OR 13.5; CI: 1.2-158.8; p<0.05) were strongly associated with the inducibility of VF, but not with family history, type 1 electrocardiogram in control, positive in late potential, maxDeltaST elevation (>==200microV) after pilsicainide test.
  
  
  CONCLUSIONS
  The symptoms, syncope, and type 1 electrocardiogram after pilsicainide test were independently associated with the electrophysiological substrate of VF in patients without apparent heart disease.
authors.affiliation: Division of Cardiology, Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Yamaguchi, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Sugi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Shimizu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ueyama
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yoshiga
authors.forename: Masahiro
authors.initials: M
authors.lastname: Doi
authors.forename: Toshihide
authors.initials: T
authors.lastname: Ohmiya
authors.forename: Makoto
authors.initials: M
authors.lastname: Ohno
authors.forename: Masaaki
authors.initials: M
authors.lastname: Yoshida
authors.forename: Masunori
authors.initials: M
authors.lastname: Matsuzaki
mesh_terms: D053840:Brugada Syndrome / Q000503:physiopathology; D004558:Electric Stimulation; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D026941:Sodium Channel Blockers; D014693:Ventricular Fibrillation / Q000209:etiology*
chemical_list: D026941:Sodium Channel Blockers; D008012:Lidocaine; C042288:pilsicainide