title: Sequential reaction of arynes via insertion into the pi-bond of amides and trapping reaction with dialkylzincs.
abstract: The sequential transformation of arynes into ortho-disubstituted arenes is achieved by a one-pot procedure using formamides and dialkylzincs. This reaction proceeded via a route involving the trapping reaction of the formal [2 + 2] cycloaddition adducts or quinone methides generated by the insertion of arynes into the C=O bond of amides.
authors.affiliation: School of Pharmacy, Hyogo University of Health Sciences, Minatojima, Chuo-ku, Kobe 650-8530, Japan.
authors.forename: Eito
authors.initials: E
authors.lastname: Yoshioka
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kohtani
authors.forename: Hideto
authors.initials: H
authors.lastname: Miyabe
mesh_terms: D000577:Amides / Q000737:chemistry*; D017967:Zinc Compounds / Q000737:chemistry*
chemical_list: D000577:Amides; D017967:Zinc Compounds