A nanoencapsulated hypocrellin A prepared by an improved microemulsion method for photodynamic treatment.
A new hypocrellin A (HA) encapsulated silica nanoparticles was prepared by an improved microemulsion method based on the unique character of cetyl trimethyl ammonium bromide (CTAB). Stable aqueous dispersions of the HA-loaded nanoparticles, with the diameter about 50 nm, owned superior photo-stability and singlet oxygen generation ability to free HA. In vitro studies demonstrated the active uptake of HA-doped nanoparticles into the cytosol of HeLa (human cervix epithelioid carcinoma) cells. Significant morphology change and phototoxicity to such impregnated tumor cells was observed upon irradiation with light. Thus, the potential of using this method to prepare silica nanoparticles as drug carriers for photodynamic therapy has been demonstrated.
Zhou
Lin
L
Department of Complex Prescription of TCM, China Pharmaceutical University, 211198 Nanjing, People's Republic of China.
Ning
Yu-Wei
YW
Wei
Shao-Hua
SH
Feng
Yu-Ying
YY
Zhou
Jia-Hong
JH
Yu
Bo-Yang
BY
Shen
Jian
J
D000970:Antineoplastic Agents / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D005260:Female; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry / Q000648:ultrastructure; D036103:Nanotechnology; D010569:Perylene / Q000031:analogs & derivatives*; D019800:Phenol; D010778:Photochemotherapy / Q000379:methods*; D011809:Quinones; D012822:Silicon Dioxide / Q000737:chemistry; D026082:Singlet Oxygen / Q000737:chemistry
D000970:Antineoplastic Agents; D004337:Drug Carriers; D011809:Quinones; D026082:Singlet Oxygen; D019800:Phenol; D010569:Perylene; D012822:Silicon Dioxide; C048388:hypocrellin A