Influence of the severity of obstructive sleep apnea on heart rate.
BACKGROUND
We sought to clarify the influence of the severity of obstructive sleep apnea (OSA) on heart rate (HR) in patients with OSA.


METHODS
We examined 136 patients who underwent overnight polysomnography together with 24-h Holter electrocardiography and who were diagnosed as having OSA [apnea-hypopnea index (AHI) >/=5]. The patients were divided into the following 3 groups: 30 with 5</= AHI <15 (group A); 33 with 15</= AHI <30 (group B); 73 with AHI >/=30 (group C). Mean HRs during 24h, wakefulness, and sleep were calculated.


RESULTS
Mean HRs during 24h, wakefulness, and sleep were significantly higher in group C than in groups A and B. Mean HRs during 24h, wakefulness, and sleep correlated positively with AHI (Spearman's rho=0.36, p<0.001; Spearman's rho=0.32, p<0.001; Spearman's rho=0.38, p<0.001; respectively). Multiple regression analyses revealed that lnAHI was independently associated with mean HRs during 24h, wakefulness, and sleep. In 21 OSA patients who started nasal continuous positive airway pressure (nCPAP) therapy, mean HRs during 24h, wakefulness, and sleep were significantly reduced at 6 months after the initiation of nCPAP.


CONCLUSIONS
The severity of OSA was independently associated with mean HRs during 24h, wakefulness, and sleep, and 6-month treatment with nCPAP reduced the values. The prognostic significance of elevated mean HRs during 24h, wakefulness, and sleep is necessary to be clarified in patients with OSA.
Kawano
Yoshiyuki
Y
Internal Medicine 2, Faculty of Medicine, Oita University, Idaigaoka 1-1, Hasama-machi, Yufu 879-5593, Japan.
Tamura
Akira
A
Watanabe
Toru
T
Kadota
Junichi
J
D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography; D011379:Prognosis; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000503:physiopathology*