LCT-13910C>T polymorphism-associated lactose malabsorption and risk for colorectal cancer in Italy.
BACKGROUND
The activity of epithelial lactase (LCT) associates with a polymorphism 13910 bp upstream the LCT-encoding gene (LCT-13910C>T). The relationship between LCT-13910C>T polymorphism and risk for colorectal cancer is unclear.


OBJECTIVE
We examined the relationship between the LCT-13910C>T polymorphism causing lactose intolerance and risk for colorectal cancer/polyps onset in the Italian population.


METHODS
793 subjects (306 with colorectal cancer, 176 with polyps and 311 controls) were genotyped for the LCT-13910C>T variant by TaqMan real time-PCR.


RESULTS
Lactose malabsorption linked to the CC genotype did not associate with an increased risk for either colorectal cancer (OR=1.041; 95% CI=0.751-1.442; p=0.868) or polyps (OR=0.927; 95% CI=0.630-1.363; p=0.769). There was no association with colorectal cancer/polyps site. 60% of the subjects overall bore the CC genotype.


CONCLUSIONS
In the Italian population the LCT-13910C>T polymorphism is not associated to the risk for colorectal cancer or polyps.
Tarabra
Elena
E
Center for Predictive Medicine, Presidio Sanitario Gradenigo, C.so Regina Margherita 8, 10153, Turin, Italy.
Pazienza
Paola
P
Borghesio
Elisabetta
E
Actis
Giovanni C
GC
Tappero
Gianfranco
G
Framarin
Luciana
L
Ayoubi
Mohammad
M
Castellino
Francesca
F
Leone
Nicola
N
Sansoè
Giovanni
G
De Paolis
Paolo
P
Comandone
Alessandro
A
Rosina
Floriano
F
D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D043322:Lactase / Q000235:genetics* / Q000378:metabolism; D007787:Lactose Intolerance / Q000150:complications / Q000201:enzymology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D043322:Lactase