title: Biodegradable poly(L-lactic acid)-lavender nanocapsules: synthesis, controlled release, and application in remedy of sleep disorder.
abstract: In this study, nanocapsules of poly(L-lactic acid) (PLLA) containing lavender oil were synthesized by solvent evaporation emulsion. Poly(L-lactic acid) is a biodegradable aliphatic polyester derived from lactic acid formed by bacterial fermentation of glucose-rich substances. Lavender oil is a plant extract that finds uses in phytotherapy. It is reputed as anti-septic, anti-depressant and sleep promoter. Encapsulation is a technique used to encase tiny oil droplets with a thin and permeable coating that allows for a controlled release of the volatile oil. The size and morphology of the nanocapsules were characterized by scanning electron microscope. The particle size and distribution were measured by photon correlation spectroscopy. The time-controlled release of the lavender oil was studied and the use of the lavender capsules in the remedy of sleep disorder was investigated.
authors.affiliation: School of Applied Sciences and Engineering, Monash University, Churchill, VIC 3842, Australia.
authors.forename: Walid A
authors.initials: WA
authors.lastname: Daoud
authors.forename: Mandy
authors.initials: M
authors.lastname: Ngan
authors.forename: Kevin
authors.initials: K
authors.lastname: Cheuk
mesh_terms: D005260:Female; D005285:Fermentation; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism* / Q000627:therapeutic use; D027523:Lavandula; D008297:Male; D053769:Nanocapsules; D010316:Particle Size; D011091:Polyesters; D011108:Polymers / Q000378:metabolism* / Q000627:therapeutic use; D012893:Sleep Wake Disorders / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D053769:Nanocapsules; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)