[Importance of molecular diagnostics in Alzheimer dementia. A case report].
Alzheimer's disease (AD) is the most frequent form of dementia worldwide. The increasing incidence of AD is due to the dramatic rise in life expectancy. Generally, AD shows a multifactorial etiology and manifests itself only at an older age. However, a small percentage of cases have a monogenic cause, are inherited as an autosomal dominant trait, and begin much earlier. In these cases, molecular analysis and genetic consultation may make sense.
Honneth
J
J
Contilia GmbH, Geriatrie-Zentrum Haus Berge, Elisabeth-Krankenhaus Essen GmbH, Essen, Deutschland. j.honneth@contilia.de
Nehen
H G
HG
Haseke
J
J
D000328:Adult; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D003704:Dementia / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D005817:Genetic Counseling; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D015336:Molecular Probe Techniques; D010375:Pedigree; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D001057:Apolipoproteins E; D005819:Genetic Markers