Matriptase does not require hepatocyte growth factor activator inhibitor type-1 for activation in an epithelial cell expression model.
Matriptase is a type II transmembrane serine protease. Paradoxically, activation of this protease is thought to require its physiological inhibitor, hepatocyte growth factor activator inhibitor type-1 (HAI-1). In the present study, however, we obtained evidence in a stable transfection experiment using Madin-Darby canine kidney cells that matriptase activation does not require HAI-1.
Miyake
Yuka
Y
Laboratory of Enzyme Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Japan.
Tsuzuki
Satoshi
S
Fushiki
Tohru
T
Inouye
Kuniyo
K
D000818:Animals; D002460:Cell Line; D004285:Dogs; D004847:Epithelial Cells / Q000378:metabolism*; D051381:Rats; D012697:Serine Endopeptidases; D057057:Serine Proteases / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D014162:Transfection
D057057:Serine Proteases; C081092:HGF activator; D012697:Serine Endopeptidases; C485595:matriptase