Protective role of complement C5a in an experimental model of Staphylococcus aureus bacteremia.
The complement system is a key component of the innate immune response. Here, we have examined the role of complement anaphylatoxin C5a in an experimental model of Staphylococcus aureus bacteremia. Our data provide compelling evidence for a protective role of C5a during staphylococcal bloodstream infection.
von Köckritz-Blickwede
Maren
M
Infection Immunology Research Group, Helmholtz Center for Infection Research, Braunschweig, Germany.
Konrad
Stephanie
S
Foster
Simon
S
Gessner
J Engelbert
JE
Medina
Eva
E
D000818:Animals; D016470:Bacteremia / Q000276:immunology*; D015936:Complement C5a / Q000235:genetics / Q000276:immunology*; D005260:Female; D007113:Immunity, Innate / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013203:Staphylococcal Infections / Q000276:immunology*
D015936:Complement C5a