Estimation of monocyte-chemoattractantprotein-1 (Mcp-1) level in patients with lupus nephritis.
OBJECTIVE
To evaluate the use of non-invasive estimation of CP-1 in urine as a good indicator for lupus nephritis activity.


METHODS
The study was conducted on 30 patients with systemic lupus erythematosus (SLE) (group I): 15 of these patients were selected without renal involvement (group I [A]), and the other 15 were selected with evidence of renal involvement (group I [B]). Further 10 age- and sex-matched healthy subjects were taken as a control group (group II). The SLE disease activity index (SLEDAI) was applied. Laboratory investigations done for the studied group of patients included: renal function tests (antinuclear antibody) titer, (anti-double-stranded DNA) titer, and monocyte chemotactic protein 1 (MCP-1) level in serum and urine samples.


RESULTS
Serum MCP-1 was significantly higher in SLE patients with nephritis than in the control group, while no significant difference was found between SLE patients without nephritis and the control group. Urinary MCP-1 in patients with active lupus nephritis (LN) were significantly higher than both patients with inactive LN and control the group. Urinary MCP-1 in SLE patients with nephritis was significantly higher than both group I (A) and group II. Urinary MCP-1 correlated positively with proteinuria, and negatively with creatinine clearance and hemoglobin; thus, urinary MCP-1 correlates with the severity of nephritis.


CONCLUSIONS
Urinary and not serum MCP-1 is a useful invasive technique for the assessment of renal disease activity in patients with LN.
Alzawawy
Ashraf
A
Alexandria Faculty of Medicine-Internal Medicine, Rheumatology Unit, Alexandria, Egypt. ashrafzawawy@hotmail.com
Zohary
Magdy
M
Ablordiny
Magdy
M
Eldalie
Mona
M
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000974:Antibodies, Antinuclear / Q000032:analysis; D015415:Biomarkers / Q000097:blood / Q000652:urine; D018932:Chemokine CCL2 / Q000097:blood / Q000652:urine*; D004247:DNA / Q000276:immunology; D005260:Female; D006801:Humans; D007677:Kidney Function Tests; D008181:Lupus Nephritis / Q000097:blood / Q000503:physiopathology / Q000652:urine*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012720:Severity of Illness Index; D055815:Young Adult
D000974:Antibodies, Antinuclear; D015415:Biomarkers; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D004247:DNA