The role of kisspeptin signalling in the regulation of the GnRH-gonadotrophin ovarian axis in mice.
Kisspeptins are a series of overlapping peptides encoded by the Kiss1 gene that are required for central activation of the hypothalamic-pituitary-ovarian axis at puberty. Mutations that interfere with kisspeptin signalling prevent normal pubertal development in humans and mice. Mutations in the kisspeptin receptor GPR54, cause infertility and hypogonadotrophic hypogonadism in humans. The failure of the Gpr54 and Kiss1 mutant mice to ovulate has led to the suggestion that kisspeptin signalling may be required for the preovulatory luteinizing hormone (LH) surge. Although kisspeptin signalling has been shown to have an important central role in regulating the physiology of the ovary, the expression profile of Kiss1 and Gpr54 suggests that they may also have direct functions in the ovary and the placenta.
Colledge
W H
WH
Reproductive Physiology Group, Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Street, Cambridge, CB2 3EG, United Kingdom. whc23@cam.ac.uk
d'Anglemont de Tassigny
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X
D000818:Animals; D005260:Female; D019204:GTP-Binding Proteins / Q000502:physiology; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology*; D006801:Humans; D059648:Kisspeptins; D051379:Mice; D010053:Ovary / Q000502:physiology*; D010060:Ovulation / Q000502:physiology; D010920:Placenta / Q000502:physiology; D011247:Pregnancy; D011627:Puberty; D015398:Signal Transduction; D025521:Tumor Suppressor Proteins / Q000502:physiology*
C106628:KISS1 protein, human; C491407:Kiss1 protein, mouse; D059648:Kisspeptins; D025521:Tumor Suppressor Proteins; D007987:Gonadotropin-Releasing Hormone; D019204:GTP-Binding Proteins