title: [Antiviral activity of sulfated polysaccharide from the brown algae Laminaria japonica against avian influenza A (H5N1) virus infection in the cultured cells].
abstract: The antiviral activity of the sulfated polysaccharide fucoidan from the brown sea algae Laminaria japonica against infection caused by highly virulent avian influenza virus (Alduck/Novosibirsk/02/05, H5N1) in the sensitive pig embryo kidney cell cultures was studied. Fucoidan was ascertained to have no cytotoxic activity and to show virucidal activity against influenza A/H5N1 virus. When given at concentrations of 50 to 500 microg/ml, fucoidan protected the cell cultures from the cytopathogenic activity of influenza virus in a dose of 0.01 TCID50/1.0 ml and was able to suppress influenza A/H5N1 virus production within 24 hours of infection when prophylactic and therapeutic-and-prophylactic treatment regimens were used.
authors.forename: I D
authors.initials: ID
authors.lastname: Makarenkova
authors.forename: P G
authors.initials: PG
authors.lastname: Deriabin
authors.forename: D K
authors.initials: DK
authors.lastname: L'vov
authors.forename: T N
authors.initials: TN
authors.lastname: Zviagintseva
authors.forename: N N
authors.initials: NN
authors.lastname: Besednova
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D053124:Influenza A Virus, H5N1 Subtype / Q000187:drug effects* / Q000502:physiology; D007795:Laminaria / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013552:Swine; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D011134:Polysaccharides; C007789:fucoidan