[Presence of antibodies against gangliosides among patients with Lyme borreliosis--preliminary study].
THE AIM of the study was the evaluation of autoantibody reaction against endogenous gangliosides in the course of Lyme borreliosis.


METHODS
Antibodies against profile of gangliosides composed of GM1, GM2, GM3, GD1a,GD1b,GT1b, GQ1b were evaluated in serum patients with early disseminated (neuroborreliosis) Lyme disease (n = 16), patients with long lasting serologic response against Borrelia burgdorferi (n = 32) and in healthy subjects (n = 16). Immunoblot test for IgG was used.


RESULTS
Antibodies were detected in all evaluated groups. In group of neuroborreliosis (lymphocytic meningitis with cranial nerve invoIvement) there was no essential difference with control group. It was stated in group of forestry workers with serological features of infection B. burgdorferi lasting for years.


CONCLUSIONS
Results of the study do not support the thesis of participation of IgG autoantibodies against gangliosides in pathogenesis early disseminated Lyme borreliosis in form of lymphocytic meningitis with cranial nerves paresis. Antibodies against endogenous glicosfingolipides in Lyme borreliosis probably can lead to affecting nervous system (demielinisation and polineuropathy) but probably require long-term immunization, what is suggested by results of examined group of patients with the multi-annual serological features of infection.
Zajkowska
Joanna M
JM
Uniwersytet Medyczny w Białymstoku, Klinika Chorób Zakaznych i Neuroinfekcji, kierownik Kliniki. zajkowsk@umwb.edu.pl
Owłasiuk
Piotr
P
Pancewicz
Sławomir A
SA
Swierzbińska
Renata
R
Kondrusik
Maciej
M
Grygorczuk
Sambor
S
Moniuszko
Anna
A
Czupryna
Piotr
P
D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D003389:Cranial Nerve Diseases / Q000276:immunology; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008193:Lyme Disease / Q000276:immunology*; D020852:Lyme Neuroborreliosis / Q000276:immunology; D008297:Male; D016920:Meningitis, Bacterial / Q000276:immunology; D008875:Middle Aged
D001323:Autoantibodies; D005732:Gangliosides; D007074:Immunoglobulin G