Palladium-catalyzed cyclocarbonylation of arynes with methyl allyl carbonates: selective synthesis of 1H-inden-1-ones.
A selective protocol for the synthesis of 2-methylene-3-substituted-2,3-dihydro-1H-inden-1-ones and 2-benzylidene-2,3-dihydro-1H-inden-1-ones has been developed via palladium-catalyzed cyclocarbonylation reactions of arynes with allyl carbonates and carbon monooxide (CO). It is noteworthy that the selectivity of this new route is depended on both substrates and ligands.
Pi
Shao-Feng
SF
Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education), Hunan Normal University, Changsha 410081, China.
Yang
Xu-Heng
XH
Huang
Xiao-Cheng
XC
Liang
Yun
Y
Yang
Guan-Nan
GN
Zhang
Xiao-Hong
XH
Li
Jin-Heng
JH
D000480:Alkynes / Q000737:chemistry*; D000498:Allyl Compounds / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry; D002254:Carbonates / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007192:Indenes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
D000480:Alkynes; D000498:Allyl Compounds; D002254:Carbonates; D007192:Indenes; D010165:Palladium; D002248:Carbon Monoxide