Mechanisms of pathogenesis in drug hepatotoxicity putting the stress on mitochondria.
Mitochondria play key roles in aerobic life and in cell death. Thus, interference of normal mitochondrial function impairs cellular energy and lipid metabolism and leads to the unleashing of mediators of cell death. The role of mitochondria in cell death due to drug hepatotoxicity has been receiving renewed attention and it is therefore timely to assess the current status of this area.
Jones
Dean P
DP
Dept of Medicine, Emory University, 4131 Rollins Research Center, Atlanta, GA 30322, USA.
Lemasters
John J
JJ
Han
Derick
D
Boelsterli
Urs A
UA
Kaplowitz
Neil
N
D056486:Chemical and Drug Induced Liver Injury; D064420:Drug-Related Side Effects and Adverse Reactions; D022781:Hepatocytes / Q000187:drug effects*; D006801:Humans; D008099:Liver / Q000187:drug effects*; D053858:Metabolic Networks and Pathways / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects*; D008954:Models, Biological