title: [The Neuropad test in the screening of peripheral neuropathy in diabetic patients].
abstract: One of the first signs of peripheral neuropathy is the loss of perspiration of the feet. Untill now, the Semmes-Weinstein monofilament test has been considered the gold test to detect early peripheral neuropathy. Recently, the Neuropad test has become available: it is a cobalt salt plaster designed to change colour from blue to pink in contact with liquids, namely sweating. The objective of this study was to find if the Neuropad test could be considered as a test for detecting peripheral autonomic neuropathy and to compare its sensitivity and specificity to the Semmes-Weinstein monofilament test. Forty diabetic patients were studied, 22 of them presented with peripheral neuropathy. The criteria used for the definition of neuropathy was based on the Neuropathy Disability Score (NDS). Under Semmes-Weinstein monofilament test, we found a sensitivity and specificity of 82% and 94%, respectively, and with the Neuropad test, a specificity of 44%, but a sensitivity of 100%. Ten patients presented a sudomotor dysfunction of the feet in the absence of peripheral neuropathy (based on the NDS criteria), and were considered as false positives. We concluded that the Neuropad test is a simple, sensitive test to screen for diabetic neuropathy. Based on the false positive results, we may consider it as a reliable test detecting neuropathy in a earlier phase.
authors.affiliation: Serviços de Endocrinologia, Hospital de Santo António, Porto.
authors.forename: Cláudia
authors.initials: C
authors.lastname: Freitas
authors.forename: André
authors.initials: A
authors.lastname: Carvalho
authors.forename: Gustavo
authors.initials: G
authors.lastname: Melo-Rocha
authors.forename: Cláudia
authors.initials: C
authors.lastname: Amaral
authors.forename: Sara
authors.initials: S
authors.lastname: Pinto
authors.forename: Rosa
authors.initials: R
authors.lastname: Guimarães
authors.forename: Helena
authors.initials: H
authors.lastname: Neto
authors.forename: José
authors.initials: J
authors.lastname: Suascun
authors.forename: José
authors.initials: J
authors.lastname: Muras
authors.forename: Isabel
authors.initials: I
authors.lastname: Gonçalves
authors.forename: Joana
authors.initials: J
authors.lastname: Martins
authors.forename: Jorge
authors.initials: J
authors.lastname: Dores
authors.forename: Rui
authors.initials: R
authors.lastname: Carvalho
authors.forename: Fátima
authors.initials: F
authors.lastname: Borges
mesh_terms: D003929:Diabetic Neuropathies / Q000175:diagnosis*; D003943:Diagnostic Techniques, Neurological; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity