title: Preparation and characterization of a new hydrophilic C60 derivative (OH)16C60CHCOOH.
abstract: C60 and its derivatives are very important nanomaterials in biological and materials science. Unfortunately, due to the high hydrophobicity of the C60 cage, most of these materials are insoluble in water and their usages are quitely restricted. Here we reported the preparation and characterization of (OH)16C60CHCOOH, a new multihydroxylated methanofullerene carboxylic acid (MMFCA) derivative with high aqueous solubility. The elementary analysis, FT-IR and 1HNMR confirmed the structure of this material. Like other C60 and its derivatives, this new derivative also contains the free radical scavenging ability, measured by electron spin resonance (ESR) test. On the other hand, the MTT assay showed it had low cytotoxicity. Therefore, this new MMFCA derivative might be a potential vehicle for the introduction of hydrophobic C60 derivatives into water or a hydrophilic environment.
authors.affiliation: School of Life Sciences, Sichuan University, Sichuan 610064, China.
authors.forename: Engao
authors.initials: E
authors.lastname: Zhu
authors.forename: Ruili
authors.initials: R
authors.lastname: Liu
authors.forename: Min
authors.initials: M
authors.lastname: Lv
authors.forename: Qingnuan
authors.initials: Q
authors.lastname: Li
authors.forename: Wenxin
authors.initials: W
authors.lastname: Li
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhao
authors.forename: Qing
authors.initials: Q
authors.lastname: Huang
mesh_terms: D002460:Cell Line; D002470:Cell Survival; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers / Q000737:chemistry; D037741:Fullerenes / Q000737:chemistry*; D006801:Humans; D017665:Hydroxyl Radical / Q000737:chemistry; D008958:Models, Molecular
chemical_list: D016166:Free Radical Scavengers; D037741:Fullerenes; D017665:Hydroxyl Radical; C069837:fullerene C60