Antidepressant-like effect of trans-resveratrol: Involvement of serotonin and noradrenaline system.
The antidepressant-like effect of trans-resveratrol, a phenolic compound present in polygonum cuspidatum, was evaluated through behavioral and neurochemical methods. trans-Resveratrol (20, 40 and 80 mg/kg, via gavage) significantly decreased the immobility time in mouse models of despair tests, but did not influence locomotor activity. Two behavioral models and neurochemical assays suggested that trans-resveratrol produced a significant increase in serotonin and noradrenaline levels at 40 or 80 mg/kg in brain regions. In addition, trans-resveratrol dose dependently inhibited MAO-A activity. These findings indicate that the antidepressant-like effect of trans-resveratrol might be related to serotonergic and noradrenergic activation.
Xu
Ying
Y
J. Crayton Pruitt Family Department of Biomedical Engineering and Evelyn F. & William L. Mcknight Brain Institute, University of Florida, Gainesville, FL 32611, USA.
Wang
Zhichao
Z
You
Wenting
W
Zhang
Xiuhua
X
Li
Shan
S
Barish
Philip A
PA
Vernon
Matthew M
MM
Du
Xia
X
Li
Gaowen
G
Pan
Jianchun
J
Ogle
William O
WO
D000818:Animals; D000928:Antidepressive Agents; D000975:Antioxidants / Q000494:pharmacology*; D001058:Apomorphine; D001522:Behavior, Animal / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D003863:Depression / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D010134:Fenclonine / Q000494:pharmacology; D019417:Hindlimb Suspension; D007035:Hypothermia / Q000139:chemically induced / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors; D009043:Motor Activity / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology*; D000077185:Resveratrol; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*; D013239:Stereotyped Behavior / Q000187:drug effects; D013267:Stilbenes / Q000494:pharmacology*; D013550:Swimming / Q000523:psychology
D000928:Antidepressive Agents; D000975:Antioxidants; D008996:Monoamine Oxidase Inhibitors; D013267:Stilbenes; D012701:Serotonin; D008995:Monoamine Oxidase; D001058:Apomorphine; D000077185:Resveratrol; D010134:Fenclonine; D009638:Norepinephrine