[To investigate the overexpression of Stat3 and Cyclin D1 in laryngeal neoplasm by immunohistochemistry].
OBJECTIVE
To investigate the overexpression of Stat3 and Cyclin D1 in laryngeal neoplasm with immunohistochemistry method.


METHODS
With immunohistochemistry method, we investigated the expression of Stat3 and Cyclin D1 in laryngeal neoplasm and analysis the relationship between Stat3 and clinical pathological factor.


RESULTS
Stat3 and Cyclin D1 overexpressed in laryngeal neoplasm tissue and they have positive relationship.


CONCLUSIONS
Active Stat3 may promote the transcription of target gene Cyclin D1, which could accelerate carcinomatous change.
Liang
Hongjun
H
Department of Otolaryngology, Shengjing Hospital, China Medical University, Shenyang, 110004, China.
Liu
Bin
B
Ji
Wenyue
W
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D019938:Cyclin D1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D050796:STAT3 Transcription Factor / Q000378:metabolism*
C530104:CCND1 protein, human; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D019938:Cyclin D1