Preparation and characterization of lectin-conjugated chitosan fluorescent nanoparticles.
The purpose of this study was to design and evaluate a novel target nanoparticle for disease detection and drug delivery using the biotin-avidin binding system. The formed lectin-conjugated chitosan fluorescent nanoparticles were of spherical shape(100-200 nm in diameter), which were more stable under light than pure fluorescein isothiocyanate (FITC).
Liu
Jingping
J
Nanomedicine Laboratory, Center for Regenerative Medicine, West China Hospital, Sichuan University, Chengdu 610041, P. R. China.
Zhang
Lanlan
L
Wang
Chen
C
Xu
Hongyan
H
Zhao
Xiaojun
X
D001710:Biotin / Q000737:chemistry; D048271:Chitosan / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D004339:Drug Compounding; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry; D037102:Lectins / Q000737:chemistry*; D018625:Microscopy, Atomic Force; D008856:Microscopy, Fluorescence; D008956:Models, Chemical; D053758:Nanoparticles / Q000737:chemistry*; D010835:Phytohemagglutinins / Q000737:chemistry; D013053:Spectrophotometry
D004337:Drug Carriers; D005456:Fluorescent Dyes; D037102:Lectins; D010835:Phytohemagglutinins; D001710:Biotin; D048271:Chitosan; D016650:Fluorescein-5-isothiocyanate