[Expressions of neurotrophic factors and their receptors in prostate cancer].
OBJECTIVE
To investigate the expressions of neurotrophic factors (NTFs) and their receptors in prostate cancer.


METHODS
We detected the expressions of the nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and their receptors TrkA, TrkB and p75 in 35 specimens of prostate cancer by Western blotting, and included 10 specimens of normal prostate tissue from young males that died accidentally.


RESULTS
Compared with the control group, the expressions of NGF and p75 were significantly decreased (P < 0.01), while those of BDNF, TrkA and TrkB significantly increased in prostate cancer (P < 0.05).


CONCLUSIONS
The changes in the expressions of NTFs and their receptors were related with the pathogenesis and progression of prostate cancer, which may be considered as reference indexes for the diagnosis of the disease.
Liu
Min
M
Department of Urology, Central Hospital of Cangzhou City, Cangzhou, Hebei 061001, China. liuminhb@126.com
Su
Yong-Hong
YH
Chen
Yu
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D016022:Case-Control Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology*; D020800:Receptor, Nerve Growth Factor / Q000378:metabolism; D020917:Receptor, trkA / Q000378:metabolism; D020813:Receptor, trkB / Q000378:metabolism; D055815:Young Adult
D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D020800:Receptor, Nerve Growth Factor; D020917:Receptor, trkA; D020813:Receptor, trkB