title: Role of dietary iodine and cruciferous vegetables in thyroid cancer: a countrywide case-control study in New Caledonia.
abstract: Exceptionally high incidence rates of thyroid cancer have been reported in New Caledonia, particularly in Melanesian women. To clarify the reasons of this elevated incidence, we conducted a countrywide population-based case-control study in the multiethnic population of Caledonian women. The study included 293 cases of thyroid cancer and 354 population controls. Based on a food frequency questionnaire, we investigated the role in thyroid cancer of food items rich in iodine-such as seafood-and of vegetables containing goitrogens-such as cruciferous vegetables. A measure of total daily iodine intake based on a food composition table was also used. Our findings provided little support for an association between thyroid cancer and consumption of fish and seafood. We found that high consumption of cruciferous vegetables was associated with thyroid cancer among women with low iodine intake (OR = 1.86; 95% CI: 1.01-3.43 for iodine intake <96 microg/day). The high consumption of cruciferous vegetables among Melanesian women, a group with mild iodine deficiency, may contribute to explain the exceptionally high incidence of thyroid cancer in this group.
authors.affiliation: Environmental Epidemiology of Cancer, CESP Centre for Research in Epidemiology and Population Health, U1018, Inserm, 16 Avenue Paul Vaillant-Couturier, 94807, Villejuif Cedex, France.
authors.forename: Thérèse
authors.initials: T
authors.lastname: Truong
authors.forename: Dominique
authors.initials: D
authors.lastname: Baron-Dubourdieu
authors.forename: Yannick
authors.initials: Y
authors.lastname: Rougier
authors.forename: Pascal
authors.initials: P
authors.lastname: Guénel
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001937:Brassica; D016022:Case-Control Studies; D004032:Diet; D005260:Female; D006801:Humans; D007455:Iodine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009510:New Caledonia / Q000453:epidemiology; D011795:Surveys and Questionnaires; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000209:etiology; D014675:Vegetables; D055815:Young Adult
chemical_list: D007455:Iodine