Hyperimmunoglobulin E syndrome with juvenile dermatomyositis and calcinosis.
Juvenile dermatomyositis (JDM) is a rare childhood disease with autoimmune association. Environmental factors are known to trigger JDM in genetically susceptible individuals (Schmieder et al., Dermatol Online 6:3, 2009). Calcinosis is a well-established complication of JDM. Prevalence is higher in children (30-70%; Özkaya et al., Erciyes Med J 30(1):40-43, 2008). Hyperimmunoglobulin E syndrome is a primary immunodeficiency syndrome with multiple recurrent abscess formation and raised serum immunoglobulin E levels. We report a case of JDM with calcinosis cutis universalis with hyperimmunoglobulin E syndrome. With a previous similar case report (Min et al., Korean J Intern Med 14:95-98, 1999), this could well be a new sequence syndrome where abscesses are the trigger for the onset of JDM.
Saikia
Bedangshu
B
Department of Pediatrics, St Stephens Hospital, Tis Hazari, New Delhi, Delhi 110054, India. bedangshu@gmail.com
Aneja
Himanshu
H
Jain
Jyoti
J
Puliyel
Jacob M
JM
D000038:Abscess / Q000097:blood* / Q000150:complications / Q000473:pathology; D002114:Calcinosis / Q000097:blood* / Q000209:etiology / Q000473:pathology; D002648:Child; D003882:Dermatomyositis / Q000097:blood* / Q000150:complications / Q000473:pathology; D006801:Humans; D016867:Immunocompromised Host; D007073:Immunoglobulin E / Q000097:blood*; D007589:Job Syndrome / Q000097:blood* / Q000473:pathology; D008297:Male; D018908:Muscle Weakness
D007073:Immunoglobulin E