Cytotherapy of osteonecrosis of the femoral head: a mini review.
The pathogenesis and aetiology of nontraumatic osteonecrosis of the femoral head has not been revealed completely. However, with advances in stem cell research and regenerative medicine, it is believed that the onset of osteonecrosis of the femoral head probably has a cellular origin, and the possible therapy of osteonecrosis of the femoral head based on cytotherapy has great potential. In this review, the aetiology of osteonecrosis of the femoral head, animal experiments and clinical applications of cytotherapy are summarized and analysed. Current problems and future challenges are discussed.
Gao
You-Shui
YS
Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China.
Zhang
Chang-Qing
CQ
D000818:Animals; D016026:Bone Marrow Transplantation; D004195:Disease Models, Animal; D005271:Femur Head Necrosis / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D011817:Rabbits