title: Gastric ischemia following endoscopic submucosal dissection of early gastric cancer.
abstract: Procedure-related complications of gastric endoscopic submucosal dissection (ESD) mainly include bleeding and perforation. Another complication is stricture formation after ESD close to the pylorus or close to the gastroesophageal junction. We report a case of an 86-year-old patient who developed extensive gastric ischemia after ESD for early gastric cancer. We suppose that the most likely reason for the ischemia was the submucosal injection of a large volume of a mixture of glycerol (10%) and epinephrine (dilution 1: 50,000) that was used, in combination with the patient's underlying cardiovascular comorbidity. Gastric ischemia as a complication of gastric ESD has not been described previously. A conservative treatment approach seems justifiable. However, close endoscopic follow up for early recognition and treatment of a resulting stricture is recommended.
authors.affiliation: Department of Gastroenterology, Klinikum Augsburg, Augsburg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Probst
authors.forename: Bruno
authors.initials: B
authors.lastname: Maerkl
authors.forename: Maximilian
authors.initials: M
authors.lastname: Bittinger
authors.forename: Helmut
authors.initials: H
authors.lastname: Messmann
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000322:Adrenergic Agonists / Q000008:administration & dosage / Q000009:adverse effects; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000150:complications; D018450:Disease Progression; D004837:Epinephrine / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005773:Gastroscopy / Q000009:adverse effects*; D005990:Glycerol / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007511:Ischemia / Q000209:etiology*; D011183:Postoperative Complications / Q000209:etiology*; D012307:Risk Factors; D012997:Solvents / Q000008:administration & dosage / Q000009:adverse effects; D013270:Stomach / Q000098:blood supply* / Q000601:surgery; D013274:Stomach Neoplasms / Q000473:pathology / Q000601:surgery*; D013997:Time Factors
chemical_list: D000322:Adrenergic Agonists; D012997:Solvents; D005990:Glycerol; D004837:Epinephrine