IL-17 is elevated in cerebrospinal fluids in bacterial meningitis in children.
Bacterial meningitis has a poor prognosis and neurologic complications. The present study aimed to investigate the cytokine/chemokine network in cerebrospinal fluid (CSF) from children with bacterial meningitis and aseptic meningitis. Interleukin (IL)-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, interferon-gamma, tumor necrosis factor-alpha, granulocyte colony-stimulating factor, granulocyte monocyte colony-stimulating factor, monocyte chemoattractant protein-1 and macrophage inflammatory protein-1beta, were measured simultaneously in CSF supernatants. We found that, IL-17 was significantly elevated in CSF with bacterial meningitis. We believe that IL-17 plays a key role in neutrophil infiltration into CSF and neuronal protection in bacterial meningitis.
Asano
Takeshi
T
Department of Pediatrics, Nippon Medical School, Chiba Hokusoh Hospital, Chiba-Pref 270-1694, Japan. VFF13540@nifty.ne.jp
Ichiki
Kunihiko
K
Koizumi
Shinya
S
Kaizu
Kiyohiko
K
Hatori
Takayuki
T
Fujino
Osamu
O
Mashiko
Kunihiro
K
Sakamoto
Yuichiro
Y
Miyasho
Taku
T
Fukunaga
Yoshitaka
Y
D018925:Chemokines / Q000097:blood / Q000134:cerebrospinal fluid; D002648:Child; D003710:Demography; D005334:Fever / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications; D006801:Humans; D020381:Interleukin-17 / Q000097:blood / Q000134:cerebrospinal fluid*; D008582:Meningitis, Aseptic / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications; D016920:Meningitis, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid* / Q000150:complications
D018925:Chemokines; D020381:Interleukin-17