title: Dianilides of dipicolinic acid function as synthetic chloride channels.
abstract: We report that N(2),N(6)-bis(4-nitrophenyl)pyridine-2,6-dicarboxamide, which is related to known isophthalic acid dianilides, transports Cl(-) ions through phospholipid bilayer membranes and shows clear evidence of channel activity.
authors.affiliation: Department of Chemistry, Washington University, Saint Louis, MO, USA.
authors.forename: Carl R
authors.initials: CR
authors.lastname: Yamnitz
authors.forename: Saeedeh
authors.initials: S
authors.lastname: Negin
authors.forename: I Alexandru
authors.initials: IA
authors.lastname: Carasel
authors.forename: Rudolph K
authors.initials: RK
authors.lastname: Winter
authors.forename: George W
authors.initials: GW
authors.lastname: Gokel
mesh_terms: D000813:Anilides / Q000737:chemistry*; D018118:Chloride Channels / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010848:Picolinic Acids / Q000737:chemistry*
chemical_list: D000813:Anilides; D018118:Chloride Channels; D010848:Picolinic Acids; C004860:dipicolinic acid