Cytokinesis and cancer.
Cytokinesis is the final stage of cell division during which the two daughter cells separate completely. Although less well understood than some of the earlier phases of the cell cycle, recent discoveries have shed light on the mechanisms that orchestrate this process, including cleavage furrow formation, midbody maturation and abscission. One of the reasons why research on cytokinesis has been attracting increasing attention is the concept that failure of this process in mammals is associated with carcinogenesis. In this minireview, we will discuss the possible links between cytokinesis and cancer, and highlight key mechanisms that connect these processes.
Sagona
Antonia P
AP
Centre for Cancer Biomedicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Stenmark
Harald
H
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D018797:Cell Cycle Proteins / Q000502:physiology; D048749:Cytokinesis / Q000502:physiology*; D056827:Endosomal Sorting Complexes Required for Transport / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008869:Microtubule-Associated Proteins / Q000502:physiology; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology; D011123:Polyploidy; D011494:Protein Kinases / Q000502:physiology
D018797:Cell Cycle Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D008869:Microtubule-Associated Proteins; D011494:Protein Kinases