Effect of atorvastatin on dendritic cells of tubulointerstitium in diabetic rats.
Inflammatory reactology has become increasingly important in diabetic kidney disease. In this study, we estabilished STZ-induced diabetic rat model to investigate whether dendritic cells (DCs) mediated tubulointerstitial damages, and whether the effects by DCs were mediated by P-selectin expression and can be inhibited by atorvastatin. The study demonstrated that there was an accumulation of DCs in diabetic rats mediated by P-selectin. It also showed the accumulation of DCs and expression of P-selectin was closely correlated with the degree of renal tubulointerstitial injury. These effects were markedly attenuated by atorvastatin. Thus, DCs play a role in tubulointerstitial damages, atorvasttin can prevent renal tubulointerstitium from damage by inhibiting the P-selectin expression and DCs migration.
Tu
Yafang
Y
Nephrology Department, Renmin Hospital of Wuhan University, Wuhan, China.
Jia
Ruhan
R
Ding
Guohua
G
Chen
Ling
L
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000069059:Atorvastatin; D002465:Cell Movement; D003713:Dendritic Cells / Q000187:drug effects* / Q000276:immunology; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D004195:Disease Models, Animal; D006538:Heptanoic Acids / Q000494:pharmacology*; D009395:Nephritis, Interstitial / Q000378:metabolism* / Q000473:pathology; D019007:P-Selectin / Q000378:metabolism; D011758:Pyrroles / Q000494:pharmacology*; D051381:Rats
D000893:Anti-Inflammatory Agents; D006538:Heptanoic Acids; D019007:P-Selectin; D011758:Pyrroles; D000069059:Atorvastatin