Alcohol intake and pancreatic cancer: a pooled analysis from the pancreatic cancer cohort consortium (PanScan).
The literature has consistently reported no association between low to moderate alcohol consumption and pancreatic cancer; however, a few studies have shown that high levels of intake may increase risk. Most single studies have limited power to detect associations even in the highest alcohol intake categories or to examine associations by alcohol type. We analyzed these associations using 1,530 pancreatic cancer cases and 1,530 controls from the Pancreatic Cancer Cohort Consortium (PanScan) nested case-control study. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated using unconditional logistic regression, adjusting for potential confounders. We observed no significant overall association between total alcohol (ethanol) intake and pancreatic cancer risk (OR = 1.38, 95% CI = 0.86-2.23, for 60 or more g/day vs. >0 to <5 g/day). A statistically significant increase in risk was observed among men consuming 45 or more grams of alcohol from liquor per day (OR = 2.23, 95% CI = 1.02-4.87, compared to 0 g/day of alcohol from liquor, P-trend = 0.12), but not among women (OR = 1.35, 95% CI = 0.63-2.87, for 30 or more g/day of alcohol from liquor, compared to none). No associations were noted for wine or beer intake. Overall, no significant increase in risk was observed, but a small effect among heavy drinkers cannot be ruled out.
Michaud
Dominique S
DS
Division of Epidemiology, Public Health and Primary Care, Imperial College London, London, UK. d.michaud@imperial.ac.uk
Vrieling
Alina
A
Jiao
Li
L
Mendelsohn
Julie B
JB
Steplowski
Emily
E
Lynch
Shannon M
SM
Wactawski-Wende
Jean
J
Arslan
Alan A
AA
Bas Bueno-de-Mesquita
H
H
Fuchs
Charles S
CS
Gross
Myron
M
Helzlsouer
Kathy
K
Jacobs
Eric J
EJ
Lacroix
Andrea
A
Petersen
Gloria
G
Zheng
Wei
W
Allen
Naomi
N
Ammundadottir
Laufey
L
Bergmann
Manuela M
MM
Boffetta
Paolo
P
Buring
Julie E
JE
Canzian
Federico
F
Chanock
Stephen J
SJ
Clavel-Chapelon
Françoise
F
Clipp
Sandra
S
Freiberg
Matthew S
MS
Michael Gaziano
J
J
Giovannucci
Edward L
EL
Hankinson
Susan
S
Hartge
Patricia
P
Hoover
Robert N
RN
Allan Hubbell
F
F
Hunter
David J
DJ
Hutchinson
Amy
A
Jacobs
Kevin
K
Kooperberg
Charles
C
Kraft
Peter
P
Manjer
Jonas
J
Navarro
Carmen
C
Peeters
Petra H M
PH
Shu
Xiao-Ou
XO
Stevens
Victoria
V
Thomas
Gilles
G
Tjønneland
Anne
A
Tobias
Geoffrey S
GS
Trichopoulos
Dimitrios
D
Tumino
Rosario
R
Vineis
Paolo
P
Virtamo
Jarmo
J
Wallace
Robert
R
Wolpin
Brian M
BM
Yu
Kai
K
Zeleniuch-Jacquotte
Anne
A
Stolzenberg-Solomon
Rachael Z
RZ
D000368:Aged; D000428:Alcohol Drinking / Q000009:adverse effects / Q000453:epidemiology*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D010190:Pancreatic Neoplasms / Q000453:epidemiology* / Q000209:etiology; D011446:Prospective Studies