title: Vitamin D deficiency in patients with osteoarthritis undergoing total hip replacement: a cause for concern?
abstract: We measured the plasma 25-hydroxyvitamin D(3) (25(OH)D(3)) levels in 62 consecutive Caucasian patients undergoing total hip replacement for osteoarthritis. The patients were divided into two groups based on whether they were vitamin D sufficient or deficient. The groups were matched for age, gender and the American Society of Anaesthesiologists (ASA) grade. The prevalence of vitamin D deficiency in our patients was comparable with recent population-based studies performed in the United Kingdom. Patients with vitamin D deficiency had lower pre-operative Harris hip scores (Mann-Whitney test, p = 0.018) and were significantly less likely to attain an excellent outcome from total hip replacement (chi-squared test, p = 0.038). Vitamin D levels were found to positively correlate with both pre- and post-operative Harris hip scores. These results warrant further study of vitamin D deficiency in patients undergoing joint replacement as it is a risk factor for a suboptimal outcome which is relatively simple and cheap to correct.
authors.affiliation: Department of Trauma and Orthopaedics University College Hospital, London NW1 2BU, UK.
authors.forename: D H
authors.initials: DH
authors.lastname: Nawabi
authors.forename: K F
authors.initials: KF
authors.lastname: Chin
authors.forename: R W
authors.initials: RW
authors.lastname: Keen
authors.forename: F S
authors.initials: FS
authors.lastname: Haddad
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip; D002112:Calcifediol / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000150:complications* / Q000601:surgery*; D010865:Pilot Projects; D011379:Prognosis; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014808:Vitamin D Deficiency / Q000097:blood / Q000150:complications*
chemical_list: D002112:Calcifediol