[Effects of perinatal exposure to sulphamethazine on the thyroid gland function of SD rats].
OBJECTIVE
To study the effect of perinatal exposure sulphamethazine on the function of thyroid gland of SD rats.


METHODS
Dams were given sulphamethazine 0, 50, 100 and 200 mg/(kg x d) respectively from gestational day (GD) 7 to postpartum day (P) 21. The sections of thyroid gland of pups 20 days after birth were stained by hematoxylin-eosin, and the expression of proliferating cell nuclear antigen (PCNA) were observed by immunohistochemistry staining.


RESULTS
Compare with control, thyroid gland showed proliferation of follicular epithelium in each experimental group, and the numbers of PCNA positive cells in thyroid gland significantly higher than that of control (P < 0.05).


CONCLUSIONS
Perinatal exposure to sulphamethazine may affect the function of thyroid gland of offspring.
Wang
Jintao
J
Department of Environmental Health, West China School of Public Health, China. wangjt620@126.com
Sun
Ding
D
Qiu
Yunliang
Y
Zhang
Hao
H
Wu
Desheng
D
D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity; D005260:Female; D008297:Male; D018811:Maternal Exposure; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013418:Sulfamethazine / Q000633:toxicity*; D013961:Thyroid Gland / Q000378:metabolism / Q000473:pathology / Q000502:physiology*
D000890:Anti-Infective Agents; D018809:Proliferating Cell Nuclear Antigen; D013418:Sulfamethazine