title: Retrospective analysis of 521 endosseous implants placed under antibiotic prophylaxis and review of literature.
abstract: OBJECTIVE
  Antibiotic prophylaxis in surgical implants has not a consensus in the scientific world. This is due both to reports and statistical studies with contradictory results, both to the risk of severe anaphylactic reactions and the emergence of antibiotic resistance and, finally, to the lack of published RCTs. The purpose of this study is to retrospectively analyze and assess the success of surgical therapy with endosseous implants inserted under antibiotic prophylaxis at the Department of Oral Sciences "S. Palazzi", University of Pavia. The data presented are compared to those published in international literature. The work is complemented by a statistical data analysis in order to propose a statistically valid judgement on the effectiveness of antibiotic prophylaxis in preventing postoperative infections.
  
  
  METHODS
  Retrospective observational study with an average follow-up of 4.5 months, until the abutment connection. Furthermore, after extensive review of the literature, published data are compared with what retrieved in our department. Patients operated consecutively from June 2002 to December 2007. Review of literature data concerning the influence of antibiotic prophylaxis on the implant success.
  
  
  RESULTS
  The data relating to post-operative complications encountered at the Division of Oral Surgery, University of Pavia and the comparison with those presented in the bibliography indicate statistically significant differences in favor of the antibiotic prophylaxis used in our department.
  
  
  CONCLUSIONS
  There were no anaphylactic reactions recorded. It seems advisable to perform implantology with prophylactic antibiotic coverage.
authors.affiliation: Departement of Oral Sciences "S. Palazzi", University of Pavia, Pavia, Italy. srizzo@unipv.it
authors.forename: S
authors.initials: S
authors.lastname: Rizzo
authors.forename: P
authors.initials: P
authors.lastname: Zampetti
authors.forename: R
authors.initials: R
authors.lastname: Rodriguez Y Baena
authors.forename: D
authors.initials: D
authors.lastname: Svanosio
authors.forename: S M
authors.initials: SM
authors.lastname: Lupi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019072:Antibiotic Prophylaxis; D003758:Dental Implantation, Endosseous; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult