title: Synthesis and structural analysis of a new class of azaspiro[3.3]heptanes as building blocks for medicinal chemistry.
abstract: Straightforward access toward previously unreported substituted, heterocyclic spiro[3.3]heptanes is disclosed. These spirocyclic systems may be considered as alternatives to 1,3-heteroatom-substituted cyclohexanes, which are otherwise insufficiently stable to allow their use in drug discovery. Conformational details are discussed on the basis of X-ray crystallographic structures.
authors.affiliation: Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland.
authors.forename: Johannes A
authors.initials: JA
authors.lastname: Burkhard
authors.forename: Carine
authors.initials: C
authors.lastname: Guérot
authors.forename: Henner
authors.initials: H
authors.lastname: Knust
authors.forename: Mark
authors.initials: M
authors.lastname: Rogers-Evans
authors.forename: Erick M
authors.initials: EM
authors.lastname: Carreira
mesh_terms: D018360:Crystallography, X-Ray; D006536:Heptanes / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D006536:Heptanes