title: Antinociceptive and toxicological effects of Dioclea grandiflora seed pod in mice.
abstract: The acute treatment of mice with an ethanolic extract from the seed pod of Dioclea grandiflora (EDgP) at doses of 75, 150 and 300 mg/kg by intraperitoneal administration produced a significant antinociceptive effect as displayed by the acetic acid-induced writhing test and the formalin test. The antinociception was observed through the first (neurogenic pain) and second (inflammatory pain) phases in the formalin test. The hot plate test did not show an increase in the antinociceptive latency whereas the motor performance was affected by the administration at 300 mg/kg at the beginning (30 minutes) of the observation period but not at later periods (60 and 120 minutes). These results suggest that EDgP has a central antinociceptive action and a possible anti-inflammatory activity in mice.
authors.affiliation: Department of Biology, Federal University of Juiz de Fora-UFJF, Juiz de Fora, 36036-900 Minas Gerais, Brazil. ritacassia.sa@bol.com.br
authors.forename: Rita de Cássia
authors.initials: Rde C
authors.lastname: da Silveira e Sá
authors.forename: Leandra Eugênia Gomes
authors.initials: LE
authors.lastname: de Oliveira
authors.forename: Franklin Ferreira de Farias
authors.initials: FF
authors.lastname: Nóbrega
authors.forename: Jnanabrata
authors.initials: J
authors.lastname: Bhattacharyya
authors.forename: Reinaldo Nóbrega
authors.initials: RN
authors.lastname: de Almeida
mesh_terms: D000700:Analgesics / Q000494:pharmacology* / Q000633:toxicity; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D052598:Dioclea / Q000737:chemistry*; D005557:Formaldehyde; D006358:Hot Temperature; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D011597:Psychomotor Performance / Q000187:drug effects*; D012639:Seeds / Q000737:chemistry
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D005557:Formaldehyde