Regulatory T cell as a target for cancer therapy.
Advances in our understanding of CD4(+)CD25(+)Foxp3(+) regulatory T cells (T(Regs)) enabled the characterization of their activities in maintaining peripheral tolerance, preventing autoimmune diseases, and limiting chronic inflammatory diseases. Ironically, an effective action of these cells during tumor development can limit beneficial responses by suppressing immunity and limiting antitumor resistance, whereas one of the main functions of the immune system is to eliminate malignant cells. During the last years, the immunological role, mechanism of action, and clinical importance of these cells were profoundly characterized and the relationship between this subset of lymphocytes and cancerous cells arises as a key factor that influences tumor development. Recent insights obtained from clinical studies and experimental mouse models expand our perception of the potential role of T(Regs) in cancer treatment. In this review we describe the basic mechanisms of T(Reg) origin and differentiation, their potential role in cancer, as well as the future perspectives concerning the modulation of these cells as a potential approach for anticancer strategies.
de Rezende
Lucas Cunha Dias
LC
Laboratory of Cellular and Molecular Biology of Human Cancer, Department of Pharmaceutical Sciences, Universidade Federal do Espírito Santo, Av. Marechal Campos S/N, Prédio do Básico Sala 5, Maruípe, Vitória, ES 29040-090, Brazil.
Silva
Ian Victor
IV
Rangel
Letícia Batista Azevedo
LB
Guimarães
Marco Cesar Cunegundes
MC
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy; D000077269:Lenalidomide; D051379:Mice; D023421:Models, Animal; D019653:Myeloablative Agonists / Q000494:pharmacology / Q000627:therapeutic use; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology; D013792:Thalidomide / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D014740:Vidarabine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use
D000970:Antineoplastic Agents; D019653:Myeloablative Agonists; D013792:Thalidomide; D003520:Cyclophosphamide; C467566:pomalidomide; D000077269:Lenalidomide; D014740:Vidarabine; C024352:fludarabine