title: A butenolide intermediate in methylenomycin furan biosynthesis is implied by incorporation of stereospecifically 13C-labelled glycerols.
abstract: The label from [3-(13)C]-L-glycerol is incorporated into the hydroxymethyl group of methylenomycin furans suggesting a butenolide intermediate in their biosynthesis.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
authors.forename: Christophe
authors.initials: C
authors.lastname: Corre
authors.forename: Stuart W
authors.initials: SW
authors.lastname: Haynes
authors.forename: Nicolas
authors.initials: N
authors.lastname: Malet
authors.forename: Lijiang
authors.initials: L
authors.lastname: Song
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Challis
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002247:Carbon Isotopes / Q000378:metabolism; D005663:Furans / Q000378:metabolism*; D005990:Glycerol / Q000378:metabolism*; D013237:Stereoisomerism; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D002247:Carbon Isotopes; D005663:Furans; C004511:butenolide; D015107:4-Butyrolactone; D005990:Glycerol