MicroRNAs and their role in gynecological tumors.
There have been only few events in the history of molecular biology that could be compared to the discovery of microRNAs and their role in cell physiology and pathology. MicroRNAs are small, single-stranded, noncoding RNAs composed of 19-25 nucleotides (∼22 nt), which have been proven to regulate gene expression at the posttranscriptional level. The regulatory function of microRNAs was demonstrated in normal and diseased conditions. In particular, it has been linked to cell cycle regulation, cell proliferation and differentiation, inflammatory response, and apoptosis. Altered expression profiles of microRNA have been observed in many pathologies, including diabetes, rheumatoid arthritis, and several cancers. To date, more than 700 human microRNAs have been identified and in silico-based analyses estimate at least 500 more to be identified. The purpose of this review is to present the current perspective on microRNAs structure and biogenesis as well as their contribution to the etiopathogenesis of gynecological tumors. We discuss results of the recent publications that indicate possibilities of microRNAs use as novel markers for tumors screening, early diagnosis, and treatment monitoring. The possible utilization of microRNAs as prognostic factors and specific therapy targets is also reviewed.
Torres
Anna
A
Laboratory of Biostructure, Human Anatomy Department, Medical University of Lublin, Lublin, Poland. anna.torres@wp.pl
Torres
Kamil
K
Maciejewski
Ryszard
R
Harvey
William H
WH
D000818:Animals; D016889:Endometrial Neoplasms / Q000235:genetics*; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008495:Medical Oncology / Q000379:methods; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*; D008954:Models, Biological; D008957:Models, Genetic; D010051:Ovarian Neoplasms / Q000235:genetics*; D002583:Uterine Cervical Neoplasms / Q000235:genetics*
D035683:MicroRNAs