title: Therapeutic implications of heparin-induced thrombocytopenia complicating acute hemodialysis.
abstract: Although patients undergoing acute hemodialysis (HD) constitute a group at risk for heparin-induced thrombocytopenia (HIT), the optimal therapeutic strategy remains undefined. We describe a case of HIT complicated with right subclavian vein thrombosis in a patient with chronic renal insufficiency undergoing acute HD for oligoanuria and pulmonary edema. Circulating anti-heparin-PF4 complex antibodies were detected. Past medical history was relevant for an otherwise unexplained self-limited episode of thrombocytopenia following acute HD one year earlier after an anterior STEMI. All sources of heparin were discontinued and alternative anticoagulation was initiated with argatroban, a direct-thrombin inhibitor with hepatic clearance, followed by transition to warfarin. Prevention of tunneled HD catheter obstruction was accomplished with low-dose alteplase catheter locking solution. No bleeding occurred with argatroban anticoagulation. Platelet count recovered and no further thrombotic complications were observed. The present report illustrates the diagnostic and therapeutic challenges of HIT complicating acute HD.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine of Porto, Hospital S. João, Porto, Portugal.
authors.forename: R
authors.initials: R
authors.lastname: Roncon-Albuquerque
authors.forename: A
authors.initials: A
authors.lastname: Beco
authors.forename: A L
authors.initials: AL
authors.lastname: Ferreira
authors.forename: C
authors.initials: C
authors.lastname: Gomes-Carvalho
authors.forename: A
authors.initials: A
authors.lastname: Costa
authors.forename: J
authors.initials: J
authors.lastname: Frazão
authors.forename: M
authors.initials: M
authors.lastname: Pestana
authors.forename: P
authors.initials: P
authors.lastname: von Hafe
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects; D005260:Female; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D006435:Renal Dialysis; D051436:Renal Insufficiency, Chronic / Q000150:complications* / Q000628:therapy; D013350:Subclavian Vein; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000150:complications* / Q000188:drug therapy*
chemical_list: D000925:Anticoagulants; D006493:Heparin