Multifaceted role of heat shock protein 70 in neurons.
Heat shock protein 70 (Hsp70) plays important roles in neural protection from stress by assisting cellular protein folding. In this review we discuss the current understanding of inducible and constitutive Hsp70 in maintaining and protecting neuronal synaptic function under normal and stressed conditions.
Lu
Tom Z
TZ
Department of Physiology, University of Toronto, 3306 MSB, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8.
Quan
Yi
Y
Feng
Zhong-Ping
ZP
D000818:Animals; D019610:Cytoprotection; D018840:HSP70 Heat-Shock Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism; D013312:Stress, Physiological; D013569:Synapses / Q000378:metabolism / Q000473:pathology
D018840:HSP70 Heat-Shock Proteins; D018377:Neurotransmitter Agents