Chemical proteomics discloses petrosapongiolide M, an antiinflammatory marine sesterterpene, as a proteasome inhibitor.
Margarucci
Luigi
L
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte don Melillo, 84084 Fisciano, Italy.
Monti
Maria Chiara
MC
Tosco
Alessandra
A
Riccio
Raffaele
R
Casapullo
Agostino
A
D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D030562:Databases, Protein; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D046988:Proteasome Endopeptidase Complex / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding; D040901:Proteomics
D000893:Anti-Inflammatory Agents; D004791:Enzyme Inhibitors; C118309:petrosaspongiolide m; D009828:Oleanolic Acid; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease