New diterpenoids from Caesalpinia species and their cytotoxic activity.
Chemical investigation on Caesalpinia crista afforded two new diterpenoids, 6beta-cinnamoyloxy-7beta-acetoxyvouacapen-5alpha-ol and 6beta,7beta-dibenzoyloxyvouacapen-5alpha-ol and on Caesalpiniapulcherrima another new diterpenoid, 12-demethyl neocaesalpin F along with several known constituents. The structures of the new compounds were settled from their 1D and 2D NMR spectral data. The cytotoxicity of these compounds was measured on two different cancer cell lines.
Das
Biswanath
B
Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 007, India. biswanathdas@yahoo.com
Srinivas
Yallamalla
Y
Sudhakar
Chithaluri
C
Mahender
Ibram
I
Laxminarayana
Keetha
K
Reddy
Parigi Raghavendar
PR
Raju
Tuniki Venugopal
TV
Jakka
Naga Mahesh
NM
Rao
Janapala Venkateswara
JV
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D029911:Caesalpinia / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology / Q000633:toxicity; D018922:HL-60 Cells; D006367:HeLa Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation
C551003:12-demethyl neocaesalpin F; C551002:6,7-dibenzoyloxyvouacapen-5-ol; C551001:6-cinnamoyloxy-7-acetoxyvouacapen-5-ol; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes