Impact of arginase II on CBF in experimental cortical impact injury in mice using MRI.
Traumatic brain injury (TBI) results in reduced cerebral blood flow (CBF) and low levels of the vasodilator nitric oxide (NO) may be involved. Arginase II negatively regulates NO production through competition for the substrate L-arginine. We determined whether arginase II-deficient (ArgII(-/-)) mice would show improved CBF after TBI through arterial spin-labeling magnetic resonance imaging (MRI). The ArgII(-/-) mice exhibit a significantly improved CBF recovery after trauma in the perilesional brain (P=0.0015) and in various other brain regions. In conclusion, arginase II deficiency leads to a better CBF recovery after TBI and implicates arginase II in hemodynamic processes.
Bitner
Brittany R
BR
Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, USA.
Brink
Danielle C
DC
Mathew
Leela C
LC
Pautler
Robia G
RG
Robertson
Claudia S
CS
D000818:Animals; D001119:Arginase; D001783:Blood Flow Velocity; D001930:Brain Injuries / Q000000981:diagnostic imaging / Q000201:enzymology* / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000098:blood supply* / Q000473:pathology; D002560:Cerebrovascular Circulation; D018810:Magnetic Resonance Angiography; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D011859:Radiography
C481673:Arg2 protein, mouse; D001119:Arginase