[Extra- and paravasation of cytotoxic drugs. Pathomechanisms and current preventive measures].
Defined anticancer drugs are able to induce severe local damages in cases of accidental extravasation. The underlying pathomechanisms differ from each other, e.g. vincristine and conventional doxorubicin, when the corresponding intervention needs hyaluronidase and dexrazoxane, respectively. Whether an intensified diagnostic measure may help to assume extent and severity of local drug extravasation more accurately, needs further clinical investigation.
Lipp
Hans-Peter
HP
Universitätsapotheke, Röntgenweg 9, 72076 Tübingen. Hans-Peter.Lipp@med.uni-tuebingen.de
D000903:Antibiotics, Antineoplastic / Q000009:adverse effects / Q000493:pharmacokinetics; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000493:pharmacokinetics; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects / Q000493:pharmacokinetics; D000971:Antineoplastic Combined Chemotherapy Protocols; D001952:Bridged-Ring Compounds / Q000009:adverse effects / Q000493:pharmacokinetics; D004347:Drug Interactions; D005119:Extravasation of Diagnostic and Therapeutic Materials; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology; D016685:Mitomycin / Q000009:adverse effects / Q000493:pharmacokinetics; D009944:Organoplatinum Compounds / Q000009:adverse effects / Q000493:pharmacokinetics; D011929:Razoxane / Q000627:therapeutic use; D043823:Taxoids / Q000009:adverse effects / Q000493:pharmacokinetics; D014748:Vinca Alkaloids / Q000009:adverse effects / Q000493:pharmacokinetics
D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D001952:Bridged-Ring Compounds; D009944:Organoplatinum Compounds; D043823:Taxoids; D014748:Vinca Alkaloids; C080625:taxane; D016685:Mitomycin; D011929:Razoxane; D006821:Hyaluronoglucosaminidase