title: Validation of a new micro-manometer pressure sensor for cardiovascular measurements in mice.
abstract: Abstract The Scisense (London, ON, Canada) micro-manometer pressure sensor is currently being used by investigators to evaluate cardiovascular physiology in mice, but has not been validated to date. The purpose of the current study is to compare the 1.2 F Scisense pressure sensor to the current gold standard produced by Millar Instruments (Houston, TX) (1.4 F). In vitro comparisons were preformed including temperature drift, frequency response analysis up to 250 Hz, and damping coefficient and natural frequency determined via a pop test. The authors also performed in vivo comparisons including pressure drift, dose-response studies to IV isoproterenol, maximum adrenergic stimulation with IV dobutamine, and simultaneous placement of both micro-manometer pressure sensors in the same intact murine hearts. The authors conclude that both sensors are equivalent, and that the Scisense pressure sensor represents an alternative to the current gold standard, the Millar micro-manometer pressure sensor for in vivo pressure measurements in the mouse.
authors.forename: Rodolfo J
authors.initials: RJ
authors.lastname: Trevino
authors.forename: Douglas L
authors.initials: DL
authors.lastname: Jones
authors.forename: Daniel
authors.initials: D
authors.lastname: Escobedo
authors.forename: John
authors.initials: J
authors.lastname: Porterfield
authors.forename: Erik
authors.initials: E
authors.lastname: Larson
authors.forename: Gary B
authors.initials: GB
authors.lastname: Chisholm
authors.forename: Amanda
authors.initials: A
authors.lastname: Barton
authors.forename: Marc D
authors.initials: MD
authors.lastname: Feldman
mesh_terms: D000818:Animals; D001698:Biomedical Engineering; D002319:Cardiovascular System / Q000473:pathology*; D004280:Dobutamine / Q000494:pharmacology; D004867:Equipment Design; D004864:Equipment and Supplies; D006352:Heart Ventricles / Q000473:pathology; D008365:Manometry / Q000295:instrumentation* / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008904:Miniaturization; D018670:Monitoring, Ambulatory / Q000379:methods*; D011312:Pressure; D013997:Time Factors
chemical_list: D004280:Dobutamine