Cancer risk in patients hospitalised for Graves' disease: a population-based cohort study in Sweden.
BACKGROUND
The possibility of an association of Graves' disease (GD) with subsequent cancers raised by certain studies.


METHODS
Using a database on 18 156 hospitalised GD patients, subsequent cancers were ascertained.


RESULTS
Increased risks of thyroid and parathyroid tumours were limited to the early follow-up period, which is probably a surveillance bias. Cancer sites with observed excess included the mouth and breast, in contrast to decreased risks of colon cancer, melanoma and non-Hodgkin's lymphoma.


CONCLUSIONS
Increased subsequent cancers in GD patients appeared to be balanced by decreased risks at other sites; chance cannot be excluded.
Shu
X
X
Center for Family and Community Medicine, Karolinska Institute, 141 83 Huddinge, Sweden. xiaochen.shu@ki.se
Ji
J
J
Li
X
X
Sundquist
J
J
Sundquist
K
K
Hemminki
K
K
D001943:Breast Neoplasms / Q000453:epidemiology; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000453:epidemiology; D005260:Female; D006111:Graves Disease / Q000150:complications*; D006801:Humans; D015994:Incidence; D008137:Longitudinal Studies; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology; D008297:Male; D008545:Melanoma / Q000453:epidemiology; D009062:Mouth Neoplasms / Q000453:epidemiology; D009369:Neoplasms / Q000453:epidemiology*; D010282:Parathyroid Neoplasms / Q000453:epidemiology; D018570:Risk Assessment; D012307:Risk Factors; D013548:Sweden / Q000453:epidemiology; D013964:Thyroid Neoplasms / Q000453:epidemiology