title: Pup grows up: in vitro characterization of the degradation of pupylated proteins.
abstract: By reconstituting the recently discovered prokaryotic ubiquitin-like protein (Pup)--proteasome degradation system in vitro, Weber-Ban and colleagues (Striebel et al, 2010) elucidate its mechanism and describe a surprising variation on the established principles of protease targeting. Nevertheless, their findings suggest that the bacterial and eukaryotic systems follow the same overall principles even if the details differ.
authors.affiliation: Department of Biochemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, IL, USA. matouschek@northwestern.edu
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Kraut
authors.forename: Andreas
authors.initials: A
authors.lastname: Matouschek
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D009169:Mycobacterium tuberculosis / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism*; D014452:Ubiquitins / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D014452:Ubiquitins; D046988:Proteasome Endopeptidase Complex; D000251:Adenosine Triphosphatases; C479920:Mpa protein, Mycobacterium tuberculosis