title: Factors associated with failure to achieve birth emphasizing a successful singleton at term following in vitro fertilization.
abstract: OBJECTIVE
  To evaluate the factors that might affect birth emphasizing a successful singleton at term (BESST) outcomes in women undergoing in vitro fertilization.
  
  
  METHODS
  A retrospective review of assisted reproduction cases from January 1, 2001, to July 31, 2005, at the Far Eastern Memorial Hospital, Taipei, Taiwan. Variables that were potentially associated with failure to achieve BESST were evaluated using univariate and multivariate logistic regression analysis.
  
  
  RESULTS
  Successful embryo transfer occurred in 297 of the 323 cases of assisted reproduction. In total, 123 women became pregnant and were enrolled for analysis, of whom 94 had live births and 55 achieved BESST. Multivariate analysis indicated that the number of embryos transferred, the presence of ovarian hyperstimulation syndrome, female infertility factors (other than tubal factors), and embryo quality were associated with increased relative risk of BESST failure, with odds ratios of 1.02 (95% confidence interval [CI], 1.01-1.02), 1.21 (95% CI, 1.08-1.36), 1.41 (95% CI, 1.22-1.62), and 0.79 (95% CI, 0.68-0.91), respectively.
  
  
  CONCLUSIONS
  The number of embryos transferred, the presence of ovarian hyperstimulation syndrome, female infertility factors other than tubal factors, and embryo quality correlate with the risk of failure to achieve BESST.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Taipei, Taiwan.
authors.forename: Yih-Ron
authors.initials: YR
authors.lastname: Lien
authors.forename: Hsin-Fen
authors.initials: HF
authors.lastname: Lu
authors.forename: Fu-Shiang
authors.initials: FS
authors.lastname: Peng
authors.forename: Bao-Chu
authors.initials: BC
authors.lastname: Chiu
authors.forename: Szu-Hsing
authors.initials: SH
authors.lastname: Yeh
authors.forename: Yu-Shih
authors.initials: YS
authors.lastname: Yang
mesh_terms: D000328:Adult; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000150:complications / Q000503:physiopathology; D016015:Logistic Models; D015999:Multivariate Analysis; D016471:Ovarian Hyperstimulation Syndrome / Q000150:complications; D011247:Pregnancy; D011256:Pregnancy Outcome; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan