title: Does monosomy 5 really exist in myelodysplastic syndromes and acute myeloid leukemia?
abstract: Abnormalities of chromosome 5 are common aberrations in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML), being del(5q) the most frequent. In contrast, monosomy 5 is not so frequent and, usually, is associated with complex karyotypes, conferring poor prognosis. The aim of this study was to analyze, by FISH for 5q31 (EGR1), a series of 28 MDS and AML cases with monosomy 5 detected by G-banding. FISH results revealed deletion of 5q31 in 24 of them (85.7%) and monosomy 5 just in three. FISH for 5q31 can complement conventional cytogenetics and improve the karyotype definition, leading to a better diagnostic and prognostic stratification.
authors.affiliation: Laboratori de Citogenètica Molecular. Servei de Patologia, Parc Salut Mar. GRETNHE, IMIM-Hospital del Mar, Barcelona, Spain.
authors.forename: Ana Belén
authors.initials: AB
authors.lastname: Galván
authors.forename: Mar
authors.initials: M
authors.lastname: Mallo
authors.forename: Leonor
authors.initials: L
authors.lastname: Arenillas
authors.forename: Marta
authors.initials: M
authors.lastname: Salido
authors.forename: Blanca
authors.initials: B
authors.lastname: Espinet
authors.forename: Carmen
authors.initials: C
authors.lastname: Pedro
authors.forename: Lourdes
authors.initials: L
authors.lastname: Florensa
authors.forename: Sergi
authors.initials: S
authors.lastname: Serrano
authors.forename: Francesc
authors.initials: F
authors.lastname: Solé
mesh_terms: D002895:Chromosomes, Human, Pair 5; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D009006:Monosomy; D009190:Myelodysplastic Syndromes / Q000235:genetics*