New flavonoids with 2BS cell proliferation promoting effect from the seeds of Trigonella foenum-graecum L.
Ten flavonoids were isolated from the ethyl acetate-soluble fraction of the ethanolic extract of the seeds of Trigonella foenum-graecum and their structures were elucidated on the basis of spectroscopic methods to be 5,7,3'-trihydroxy-5'-methoxylisoflavone (1), biochanin A (2), formononetin (3), irilone (4), tricin (5), daidzein (6), calycosin (7), orientin-2''-O-p-trans-coumarate (8), vitexin-2''-O-p-trans-coumarate (9), and tricin-7-O-beta-D: -glucopyranoside (10). Compounds 1 and 8 are new flavonoids, and 8 and 9 strongly promoted 2BS cell proliferation induced by H(2)O(2).
Wang
Guo-Rong
GR
Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, China.
Tang
Wen-Zhao
WZ
Yao
Qing-Qiang
QQ
Zhong
Hao
H
Liu
Yong-Jun
YJ
D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D003373:Coumaric Acids / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D019833:Genistein / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007529:Isoflavones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry*; D029910:Trigonella / Q000737:chemistry*
D003373:Coumaric Acids; D005419:Flavonoids; D005960:Glucosides; D007529:Isoflavones; D010936:Plant Extracts; C530234:irilone; C121707:7,3'-dihydroxy-4'-methoxyisoflavone; C007768:formononetin; D006861:Hydrogen Peroxide; C017769:tricin; D019833:Genistein; C004541:biochanin A