title: Surveillance of FAP: a prospective blinded comparison of capsule endoscopy and other GI imaging to detect small bowel polyps.
abstract: BACKGROUND
  Familial adenomatous polyposis (FAP) is a hereditary disorder characterized by polyposis along the gastrointestinal tract. Information on adenoma status below the duodenum has previously been restricted due to its inaccessibility in vivo. Capsule Endoscopy (CE) may provide a useful adjunct in screening for polyposis in the small bowel in FAP patients. This study aims to evaluate the effectiveness of CE in the assessment of patients with FAP, compared to other imaging modalities for the detection of small bowel polyps.
  
  
  METHODS
  20 consecutive patients with previously diagnosed FAP and duodenal polyps, presenting for routine surveillance of polyps at The Royal Melbourne Hospital were recruited. Each fasted patient initially underwent a magnetic resonance image (MRI) of the abdomen, and a barium small bowel follow-through study. Capsule Endoscopy was performed four weeks later on the fasted patient. An upper gastrointestinal side-viewing endoscopy was done one (1) to two (2) weeks after this. Endoscopists and investigators were blinded to results of other investigations and patient history.
  
  
  RESULTS
  Within the stomach, upper gastrointestinal endoscopy found more polyps than other forms of imaging. SBFT and MRI generally performed poorly, identifying fewer polyps than both upper gastrointestinal and capsule endoscopy. CE was the only form of imaging that identified polyps in all segments of the small bowel as well as the only form of imaging able to provide multiple findings outside the stomach/duodenum.
  
  
  CONCLUSIONS
  CE provides important information on possible polyp development distal to the duodenum, which may lead to surgical intervention. The place of CE as an adjunct in surveillance of FAP for a specific subset needs consideration and confirmation in replication studies.
  
  
  BACKGROUND
  Australian New Zealand Clinical Trials Registry ACTRN12608000616370.
authors.affiliation: Department of Colorectal Medicine and Genetics, The Royal Melbourne Hospital, Melbourne, Australia. Finlay.Macrae@mh.org.au.
authors.forename: Paul
authors.initials: P
authors.lastname: Tescher
authors.forename: Finlay A
authors.initials: FA
authors.lastname: Macrae
authors.forename: Tony
authors.initials: T
authors.lastname: Speer
authors.forename: Damien
authors.initials: D
authors.lastname: Stella
authors.forename: Robert
authors.initials: R
authors.lastname: Gibson
authors.forename: Jason A
authors.initials: JA
authors.lastname: Tye-Din
authors.forename: Geeta
authors.initials: G
authors.lastname: Srivatsa
authors.forename: Ian T
authors.initials: IT
authors.lastname: Jones
authors.forename: Kaye
authors.initials: K
authors.lastname: Marion