Warfarin: to use or not to use in chronic kidney disease patients?
Is the risk of major bleeding the only reason to be concerned about oral anticoagulant therapy in chronic kidney disease patients? We consider another potential adverse effect of long-term Coumadin use in chronic kidney disease patients as comparably devastating: the threat of inducing creeping vascular calcification.
Cozzolino
Mario
M
Division of Nephrology, University of Milan, S. Paolo Hospital, Via A. di Rudini 8, Milan, Italy. mariocozzolino@hotmail.com
Brandenburg
Vincent
V
D000925:Anticoagulants / Q000009:adverse effects*; D002135:Calcium-Binding Proteins / Q000502:physiology; D002908:Chronic Disease; D016326:Extracellular Matrix Proteins / Q000502:physiology; D006801:Humans; D007674:Kidney Diseases / Q000150:complications*; D007676:Kidney Failure, Chronic / Q000150:complications; D006435:Renal Dialysis; D014859:Warfarin / Q000009:adverse effects*; D000097568:Matrix Gla Protein
D000925:Anticoagulants; D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; D014859:Warfarin; D000097568:Matrix Gla Protein