[Preliminary study of metabonomcs on aqueous extract of Evodia rutaecarpa in sprague-dawley rats].
OBJECTIVE
To study the change of endogenous metabolites of SD rats administrated of aqueous extract of Evodiae rutaecarpa.


METHODS
Six SD rats had been successively administrated aqueous extract of E. rutaecarpa (0.3857 g x kg(-1)) for 33 days. An agilent 1200 6410 triplequadrupole mass spectrometer was used for the analysis of endogenous metabolites in rat urine samples. These data was analyzed by the principal component analysis (PCA) and PLS-DA using the SIMCA-P 10.0 software.


RESULTS
The significant difference in metabolic profiles between the control group and the dosed group was well observed by PCA of the MS data.


CONCLUSIONS
The E. rulaecarpa has changed the endogenous metabolites of SD rats. This work can provide the base for the further research on the interpretation of drug property of E. rulaecarpa.
Zhang
Qiyun
Q
Key Laboratory of Modern Preparation, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330006, China.
Xu
Guoliang
G
Wu
Licun
L
Ma
Xiaoxue
X
Zeng
Zhijun
Z
Huang
Liping
L
Yu
Riyue
R
Liu
Hongning
H
D000818:Animals; D032086:Evodia / Q000737:chemistry*; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D008297:Male; D055432:Metabolomics / Q000379:methods*; D010936:Plant Extracts / Q000494:pharmacology*; D025341:Principal Component Analysis; D051381:Rats; D017207:Rats, Sprague-Dawley
D010936:Plant Extracts