title: [Analysis of safety and effects on the oral whole cell/recombinant B subunit cholera vaccine in university students and workers].
abstract: OBJECTIVE
  To evaluate the safety, immunogenicity and protective efficiency of the oral whole cell/recombinant B subunit cholera vaccine in Beijing Olympic volunteers and workers.
  
  
  METHODS
  Analyzing the incidence rate of adverse reaction and Protective Rate (PR) after taking the vaccine in Olympic volunteers in 6 universities in Beijing; comparing the anti-cholera toxin (CT) detected with ELISA prior and after taking the vaccine in Olympic workers.
  
  
  RESULTS
  The total rate of adverse reaction of Olympic volunteers was 0.38%; the main side effects were gastrointestinal symptoms, such as bellyache and diarrhea which were mild and temple; the acute diarrhea incidence rate of Olympic volunteers after taking the vaccine was significantly lower than those not taking it, the PR was 76.27%; the positive rate of anti-CT of Olympic workers after taking the vaccine was significantly higher than those before taking it, the levels of anti-CT titers declined after 6 months since they had taken the vaccine.
  
  
  CONCLUSIONS
  The results from above two observed population indicate that the oral rBS-WC cholera vaccine is efficient and safe.
authors.affiliation: Center of Disease Control and Prevention, Chaoyang District, Beijing 100021, China. shinianmin@sina.com
authors.forename: Nian-min
authors.initials: NM
authors.lastname: Shi
authors.forename: Feng-ji
authors.initials: FJ
authors.lastname: Luo
authors.forename: Shu-ming
authors.initials: SM
authors.lastname: Li
authors.forename: Yun-hua
authors.initials: YH
authors.lastname: Bai
authors.forename: Yan
authors.initials: Y
authors.lastname: Qu
authors.forename: Xin
authors.initials: X
authors.lastname: Song
mesh_terms: D000906:Antibodies / Q000032:analysis*; D002771:Cholera / Q000517:prevention & control*; D002772:Cholera Toxin / Q000276:immunology; D022121:Cholera Vaccines / Q000009:adverse effects* / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D013334:Students; D014614:Vaccines, Synthetic / Q000009:adverse effects / Q000276:immunology; D055815:Young Adult
chemical_list: D000906:Antibodies; D022121:Cholera Vaccines; D014614:Vaccines, Synthetic; D002772:Cholera Toxin