title: Distinct mechanisms for the pro-apoptotic conformational transition and alkaline transition in cytochrome c.
abstract: We demonstrate for the first time that cytochrome c undergoes a distinct pathway in the alkaline conformational transition from its pro-apoptotic conformational transition, which may have important functional consequences in vivo.
authors.affiliation: Department of Chemistry & Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.
authors.forename: Tianlei
authors.initials: T
authors.lastname: Ying
authors.forename: Zhong-Hua
authors.initials: ZH
authors.lastname: Wang
authors.forename: Fangfang
authors.initials: F
authors.lastname: Zhong
authors.forename: Xiangshi
authors.initials: X
authors.lastname: Tan
authors.forename: Zhong-Xian
authors.initials: ZX
authors.lastname: Huang
mesh_terms: D017209:Apoptosis; D045304:Cytochromes c / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008672:Metals, Alkali / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D009154:Mutation; D011487:Protein Conformation
chemical_list: D008672:Metals, Alkali; D045304:Cytochromes c