title: Vincristine, an efficacious alternative for diffuse neonatal haemangiomatosis.
abstract: Diffuse neonatal haemangiomatosis (DNH) is an uncommon condition characterized by multiple cutaneous and visceral haemangiomas frequently causing severe complications. Corticosteroids constitute the first therapeutic line; however, when they fail, other alternatives are available, provided possible side effects are closely monitored during and after treatment. We present a case of life-threatening DNH, non-responsive to corticosteroids, successfully treated with Vincristine with minor side effects. We conclude that Vincristine is a valid alternative in corticosteroid-resistant DNH.
authors.affiliation: Servicio de Neonatología, Hospital Universitario Materno-Infantil La Fe, Valencia, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Pérez-Valle
authors.forename: M
authors.initials: M
authors.lastname: Peinador
authors.forename: P
authors.initials: P
authors.lastname: Herraiz
authors.forename: P
authors.initials: P
authors.lastname: Saénz
authors.forename: G
authors.initials: G
authors.lastname: Montoliu
authors.forename: M
authors.initials: M
authors.lastname: Vento
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm; D006391:Hemangioma / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D008099:Liver / Q000201:enzymology; D008113:Liver Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*; D014750:Vincristine / Q000627:therapeutic use*
chemical_list: D000305:Adrenal Cortex Hormones; D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine