cis-Clerodane-type furanoditerpenoids from Tinospora crispa.
Phytochemical and cytotoxicity investigations on organic solvent extracts of the aerial parts of Tinospora crispa have led to the isolation of 15 cis-clerodane-type furanoditerpenoids. Of these, nine compounds (1-9) were found to be new. Spectroscopic assignments of a previously reported compound, borapetoside A (13), were revised on the basis of HMQC and HMBC correlations. No discernible activity was observed when compounds 10-13 were subjected to evaluation in cytotoxicity assays against human prostate cancer (PC-3) and the normal mouse fibroblast (3T3) cell lines.
Choudhary
M Iqbal
MI
H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
Ismail
Muhammad
M
Shaari
Khozirah
K
Abbaskhan
Ahmed
A
Sattar
Samina A
SA
Lajis
Nordin H
NH
Atta-ur-Rahman
D016475:3T3 Cells; D000818:Animals; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008296:Malaysia; D008297:Male; D051379:Mice; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D011471:Prostatic Neoplasms; D013237:Stereoisomerism; D031610:Tinospora / Q000737:chemistry*
D045785:Diterpenes, Clerodane