title: Distributed self-regulation of living tissue: beyond the ideal limit.
abstract: The present paper is devoted to mathematical description of the vascular network response to local perturbations in the cellular tissue state, being one of the basic mechanisms controlling the inner environment of human body. Keeping in mind individual organs we propose a model for distributed self-regulation of living tissue, which is regarded as an active hierarchical system without any controlling center. This model is based on the self-processing of information about the cellular tissue state and cooperative interaction of blood vessels governing redistribution of blood flow over the vascular network. The information self-processing is implemented via mass conservation, i.e., conservation of blood flow as well as special biochemical compounds called activators transported by blood. The cooperative interaction of blood vessels stems from the response of individual vessels to activators in blood flowing through them. The general regularities are used to specify the vessel behavior. The arterial and venous beds are considered to be individually of the tree form. The constructed governing equations are analyzed numerically. In particular, first, we show that the blood perfusion rate approximately (in the analyzed case within 10% accuracy) depends only on the local concentration of activators in the cellular tissue. It is due to the hierarchical structure of the vascular network rather than the ideal behavior of individual vessels accepted previously. Second, we demonstrate the distinction between the reaction thresholds of individual vessels and that of the vascular network as a whole. The latter effect is the cause for introducing the notion of activators instead of using such quantities as temperature in describing the living tissue self-regulation.
authors.affiliation: Moscow Technical University of Radioengineering, Electronics, and Automation, Vernadsky 78, 119454 Moscow, Russia. kloom@mail.ru
authors.forename: Wassily
authors.initials: W
authors.lastname: Lubashevsky
authors.forename: Ihor
authors.initials: I
authors.lastname: Lubashevsky
authors.forename: Reinhard
authors.initials: R
authors.lastname: Mahnke
mesh_terms: D001775:Blood Circulation; D001808:Blood Vessels / Q000166:cytology / Q000502:physiology*; D002470:Cell Survival; D006801:Humans; D008954:Models, Biological