A review: recent advances and future prospects of taxol-producing endophytic fungi.
In the urgent search for more effective ways to treat cancer, new extraction methods of taxol from endophytic fungus have demonstrated high potential in increasing the efficiency of taxol extraction for more efficient and sustainable production of taxol and cancer treatment products. This paper summarizes recent advances in taxol-producing endophytic fungi, both in China and abroad, in the following areas: isolation and identification of endophytic fungi types, extraction and detection methods of endophytic taxol in plants, and improved efficiency of the extraction process. With the advancement of science and technology, new techniques in biotechnology, such as fungal strain improvement and recombining technique and microbial fermentation engineering, have increased the extraction yield from taxol-producing fungi, thereby improved the overall efficiency of taxol production.
Zhou
Xuanwei
X
Plant Biotechnology Research Center, School of Agriculture and Biology, Fudan-SJTU-Nottingham Plant Biotechnology R&D Center, Shanghai Jiao Tong University, Shanghai, 200240, People's Republic of China. xuanweizhou@sjtu.edu.cn
Zhu
Huifang
H
Liu
Lu
L
Lin
Juan
J
Tang
Kexuan
K
D001709:Biotechnology / Q000379:methods / Q000639:trends; D002681:China; D005285:Fermentation; D005658:Fungi / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism*; D009154:Mutation; D009172:Mycology / Q000379:methods / Q000639:trends; D017239:Paclitaxel / Q000096:biosynthesis*
D017239:Paclitaxel