Metastatic breast carcinoma presenting with profound hypocalcemia.
Hypocalcemia is a rare complication of malignancy. We present the case of a 30-year-old lady presenting with a grand mal seizure due to profound hypocalcemia. She was subsequently found to be hypoparathyroid and was diagnosed with metastatic breast carcinoma. Treatment with goserelin and exemestane produced a significant reduction in her tumor load and a correction of her hypocalcemia, which was initially refractory to treatment. We believe this to be the first case of metastatic breast carcinoma actually presenting with hypocalcemia and feel that clinicians should be aware of this rare complication.
Cooksley
Timothy
T
Diabetes and Endocrinology Unit, Department of Medicine, University Hospital of South Manchester, Wythenshawe, Manchester, United Kingdom. cooks199@hotmail.com
Banerjee
Moulinath
M
Younis
Naveed
N
D000328:Adult; D000730:Androstadienes / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy; D002277:Carcinoma / Q000150:complications* / Q000188:drug therapy; D004830:Epilepsy, Tonic-Clonic / Q000209:etiology; D005260:Female; D017273:Goserelin / Q000627:therapeutic use; D006801:Humans; D006996:Hypocalcemia / Q000209:etiology*; D009362:Neoplasm Metastasis
D000730:Androstadienes; D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D017273:Goserelin; C056516:exemestane