title: Electrospun composite nanofiber fabrics containing uniformly dispersed antimicrobial agents as an innovative type of polymeric materials with superior antimicrobial efficacy.
abstract: Herein we report that electrospun composite nanofiber fabrics containing uniformly dispersed antimicrobial agents and having large surface-to-mass ratios are an innovative type of antimicrobial polymeric materials with durable, nonleachable, and biocompatible characteristics, and more importantly, superior antimicrobial efficacy. Specifically, electrospun cellulose acetate (CA) nanofiber fabrics containing an N-halamine antimicrobial agent of bis(N-chloro-2,2,6,6-tetramethyl-4-piperidinyl) sebacate (Cl-BTMP) were prepared and evaluated; the results of antimicrobial efficacy indicated that the electrospun composite nanofiber fabrics substantially outperformed the control samples that were solution-cast films containing identical amounts of CA and Cl-BTMP. Additionally, the results of trypan blue assay test suggested that the electrospun composite nanofiber fabrics also had excellent mammal cell viability. The developed electrospun composite nanofiber fabrics with superior antimicrobial efficacy are expected to find vital applications in biomedical, hygienic, and many other fields.
authors.forename: Xinbo
authors.initials: X
authors.lastname: Sun
authors.forename: Lifeng
authors.initials: L
authors.lastname: Zhang
authors.forename: Zhengbing
authors.initials: Z
authors.lastname: Cao
authors.forename: Ying
authors.initials: Y
authors.lastname: Deng
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Hao
authors.initials: H
authors.lastname: Fong
authors.forename: Yuyu
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning / Q000379:methods; D002470:Cell Survival; D002482:Cellulose / Q000031:analogs & derivatives* / Q000737:chemistry; D004563:Electrochemistry / Q000379:methods; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning / Q000379:methods; D057139:Nanofibers; D036103:Nanotechnology / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000382:microbiology; D013696:Temperature
chemical_list: D000890:Anti-Infective Agents; D011108:Polymers; C005062:acetylcellulose; D002482:Cellulose