title: Metastatic breast carcinoma presenting with profound hypocalcemia.
abstract: Hypocalcemia is a rare complication of malignancy. We present the case of a 30-year-old lady presenting with a grand mal seizure due to profound hypocalcemia. She was subsequently found to be hypoparathyroid and was diagnosed with metastatic breast carcinoma. Treatment with goserelin and exemestane produced a significant reduction in her tumor load and a correction of her hypocalcemia, which was initially refractory to treatment. We believe this to be the first case of metastatic breast carcinoma actually presenting with hypocalcemia and feel that clinicians should be aware of this rare complication.
authors.affiliation: Diabetes and Endocrinology Unit, Department of Medicine, University Hospital of South Manchester, Wythenshawe, Manchester, United Kingdom. cooks199@hotmail.com
authors.forename: Timothy
authors.initials: T
authors.lastname: Cooksley
authors.forename: Moulinath
authors.initials: M
authors.lastname: Banerjee
authors.forename: Naveed
authors.initials: N
authors.lastname: Younis
mesh_terms: D000328:Adult; D000730:Androstadienes / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications* / Q000188:drug therapy; D002277:Carcinoma / Q000150:complications* / Q000188:drug therapy; D004830:Epilepsy, Tonic-Clonic / Q000209:etiology; D005260:Female; D017273:Goserelin / Q000627:therapeutic use; D006801:Humans; D006996:Hypocalcemia / Q000209:etiology*; D009362:Neoplasm Metastasis
chemical_list: D000730:Androstadienes; D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D017273:Goserelin; C056516:exemestane