One-pot synthesis of substituted di-hydrofurans from Lewis base-catalyzed three-component condensation.
A one-pot synthesis of substituted dihydrofurans was developed through a Lewis base-catalyzed three-component cascade condensation between nitroalkenes, aldehydes, and 1,3-dicarbonyl compounds. The desired cyclization products were prepared with a large substrate scope (22 examples) and excellent diastereoselectivity (only trans isomers) in good to excellent yields (up to 95%).
Zhong
Cheng
C
C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506, USA.
Liao
Tao
T
Tuguldur
Odbadrakh
O
Shi
Xiaodong
X