title: Acute dichlorvos poisoning induces hemorheological abnormalities in rabbits via oxidative stress.
abstract: Dichlorvos is an important insecticide used largely. Some studies have demonstrated that organophosphate pesticide has effects on erythrocyte membrane structures, which is critical to erythrocyte function and hemorheology. The aim of the present study was to explore the effect of oxidative stress on hemorheological changes during dichlorvos poisoning in rabbits. Data indicated that after dichlorvos exposure the hematocrit adjusted viscosity at high shear rate increased and erythrocyte membrane fluidity decreased. Data obtained from plasma showed that lipid peroxidative substance-malonaldehyde was elevated and superoxide dismutase was reduced. In summary, oxidative stress does occur in dichlorvos poisoning and may lead to hemorheological alterations. The changes of hemorheology may be responsible for the pathophysiology of the dichlorvos poisoning.
authors.affiliation: Hemorheology Center, Department of Biophysics, Peking University Health Science Center, Beijing, China.
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Zhang
authors.forename: Weijuan
authors.initials: W
authors.lastname: Yao
authors.forename: Binbin
authors.initials: B
authors.lastname: Jia
authors.forename: Dagong
authors.initials: D
authors.lastname: Sun
authors.forename: Weibo
authors.initials: W
authors.lastname: Ka
authors.forename: Dongqi
authors.initials: D
authors.lastname: He
authors.forename: Xifu
authors.initials: X
authors.lastname: Wang
authors.forename: Zongyao
authors.initials: Z
authors.lastname: Wen
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood; D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D004006:Dichlorvos / Q000633:toxicity*; D004907:Erythrocyte Deformability / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects; D005340:Fibrinogen / Q000378:metabolism; D006400:Hematocrit; D018056:Hemorheology; D007306:Insecticides / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D008560:Membrane Fluidity / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D011817:Rabbits; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D002800:Cholinesterase Inhibitors; D007306:Insecticides; D004006:Dichlorvos; D005340:Fibrinogen; D013482:Superoxide Dismutase; D000110:Acetylcholinesterase