title: Copper-catalyzed enantioselective 1,4-addition to alpha,beta-unsaturated aldehydes.
abstract: The first asymmetric Cu-catalyzed conjugate addition of dialkylzinc zinc reagents to a large scope of enals in presence of phosphoramidite, SimplePhos, or (R)-BINAP ligands with enantiomeric excesses up to 90% is reported. Moreover, ACA of Grignard reagents afforded moderate to good 1,4-regioselectivities with enantioselectivities up to 90%.
authors.affiliation: Department of Organic Chemistry, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneve, Switzerland.
authors.forename: Laëtitia
authors.initials: L
authors.lastname: Palais
authors.forename: Lucille
authors.initials: L
authors.lastname: Babel
authors.forename: Adrien
authors.initials: A
authors.lastname: Quintard
authors.forename: Sébastien
authors.initials: S
authors.lastname: Belot
authors.forename: Alexandre
authors.initials: A
authors.lastname: Alexakis