NW-G01, a novel cyclic hexapeptide antibiotic, produced by Streptomyces alboflavus 313: II. Structural elucidation.
NW-G01 is a novel cyclic hexapeptide antibiotic produced by Streptomyces alboflavus 313. Its relative structure was established by HR-ESI-MS, IR, 1D and 2D NMR techniques, the absolute structure was determined using a combination of single-crystal X-ray diffraction and Marfey's method finally. The antibiotic consists of L-valine, (3S)- and (3R)-piperazic acids, N-methyl-D-alanine and (2S,3aR,8aS)-6-chloro-3a-hydroxy-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid.
Guo
Zhengyan
Z
Institute of Pesticide Science, Northwest Agricultural & Forestry University, Shaanxi, China.
Ji
Zhiqin
Z
Zhang
Jiwen
J
Deng
Jing
J
Shen
Ling
L
Liu
Wei
W
Wu
Wenjun
W
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D047630:Depsipeptides / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism; D013302:Streptomyces / Q000378:metabolism; D014961:X-Ray Diffraction
D000900:Anti-Bacterial Agents; D047630:Depsipeptides; C544293:NW-G01