title: The role of the PTEN gene in malignant gliomas.
abstract: This article focuses on the latest data about the role of the gene for phosphatase and tensin homologue located on chromosome 10 (PTEN) in malignant gliomas. PTEN acts as a tumour suppressor gene and plays a critical role in cell cycle progression, angiogenesis, migration, invasions and stem cell regulation. Furthermore, there is an interaction with other tumour suppressor genes. We discuss the role of miRNAs in modulating PTEN expression and also PTEN's role in the nucleus.
authors.affiliation: Department of Neurosurgery, University Hospital of Ioannia, Ioannina, Greece. alexiougrg@yahoo.gr
authors.forename: George A
authors.initials: GA
authors.lastname: Alexiou
authors.forename: Spyridon
authors.initials: S
authors.lastname: Voulgaris
mesh_terms: D021581:Active Transport, Cell Nucleus; D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics*; D002467:Cell Nucleus / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000235:genetics*; D006801:Humans; D051059:PTEN Phosphohydrolase / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human