Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination.
Hepatitis B-specific memory B cell (HSMBC) frequencies were measured following hepatitis B vaccination in 15 HIV uninfected and 12 HIV infected adolescents. HSMBC were detected at significantly lower frequencies in HIV infected than in HIV uninfected individuals. The detection of HBsAb >10mIU/ml at study week 28 was strongly associated with the detection of HSMBC and a direct correlation between HBsAb titers and HSMBC frequencies was observed. In HIV uninfected individuals, antibody titers >1000mIU/ml were associated with higher HSMC frequencies. Lower HSMBC frequencies, reduced memory B cell (MBC) proliferation, and altered B cell phenotypes were measured in viremic HIV infected individuals compared with aviremic HIV infected or HIV uninfected individuals.
Mehta
Nishaki
N
Department of Pediatrics and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA, United States.
Cunningham
Coleen K
CK
Flynn
Patricia
P
Pepe
Joyce
J
Obaro
Stephen
S
Kapogiannis
Bill G
BG
Bethel
James
J
Luzuriaga
Katherine
K
D000293:Adolescent; D001402:B-Lymphocytes / Q000276:immunology* / Q000821:virology; D049109:Cell Proliferation; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology; D006509:Hepatitis B / Q000150:complications / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D008137:Longitudinal Studies; D008297:Male; D055815:Young Adult
D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines