Hopane-type triterpenes and binaphthopyrones from the scale insect pathogenic fungus Aschersonia paraphysata BCC 11964.
Two new triterpenes, 17(21)-hopene-6alpha,12beta-diol (1) and 17(21)-hopen-12beta-ol (2), the known 17(21)-hopen-6alpha-ol (zeorinin, 3), and two new biarylic dihydronaphthopyrones, aschernaphthopyrones A (4) and B (5), were isolated from the scale insect pathogenic fungus Aschersonia paraphysata BCC 11964. Hopene 1 and aschernaphthopyrone A (4) exhibited antimalarial activity with IC(50) values of 15 and 7.3 microM, respectively.
Isaka
Masahiko
M
National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand. isaka@biotec.or.th
Yangchum
Arunrat
A
Rachtawee
Pranee
P
Komwijit
Somjit
S
Lutthisungneon
Apisara
A
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D018432:Drug Resistance, Multiple / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D006999:Hypocreales / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D007313:Insecta / Q000382:microbiology; D007624:KB Cells; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D013785:Thailand; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014709:Vero Cells
C549673:17(21)-hopen-12beta-ol; C549672:17(21)-hopene-6alpha,12beta-diol; D000962:Antimalarials; D009281:Naphthalenes; D011753:Pyrones; D014315:Triterpenes; C549670:aschernaphthopyrone A; C549671:aschernaphthopyrone B; C028765:diploptene