title: [Prognostic value of pretherapeutic 18F-FDG PET/CT in cancer of the uterine cervix: a retrospective study of 53 patients].
abstract: OBJECTIVE
  Assessment of prognostic value of pretherapeutic (18)F-FDG PET/CT (PET).
  
  
  METHODS
  Retrospective study of 53 patients with invasive uterine cervix carcinoma. Each patient has been evaluated with pretherapeutic whole-body FDG PET/CT and pelvic MRI. Minimal follow-up lasted for 1 year. On PET/CT, we have visually analyzed metabolism of primary tumor, pelvic and para-aortic lymph nodes in comparison with surrounding structures. We have compared prognostic factors as pretherapeutic haemoglobin rate, FIGO staging, MRI and PET/CT data using Mann-Whitney univariate analysis and Cox multivariate analysis.
  
  
  RESULTS
  Para-aortic lymph node abnormal uptake on PET/CT was the only independent predictor of progression-free survival. Pelvic lymph node involvement on PET/CT was the only independent predictor of overall survival. MRI did not provide any additional information.
  
  
  CONCLUSIONS
  Lymph node involvement visually assessed by (18)F-FDG PET/CT was the most significant prognostic factor for overall and progression-free survival.
authors.affiliation: Département de médecine nucléaire, centre Henri-Becquerel et centre hospitalo-universitaire de Rouen, Rouen, France. m.chastan@hotmail.fr
authors.forename: M
authors.initials: M
authors.lastname: Chastan
authors.forename: A
authors.initials: A
authors.lastname: Manrique
authors.forename: M
authors.initials: M
authors.lastname: Baron
authors.forename: A Edet
authors.initials: AE
authors.lastname: Sanson
authors.forename: B
authors.initials: B
authors.lastname: Diologent
authors.forename: P
authors.initials: P
authors.lastname: Vera
authors.forename: A
authors.initials: A
authors.lastname: Hitzel
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology; D018572:Disease-Free Survival; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D011379:Prognosis; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18