Intracranial manifestations in SAPHO syndrome: the first case report in literature.
A 41-year-old woman with SAPHO syndrome presented with numbness of her left arm followed by a generalized seizure. Computed tomography and magnetic resonance imaging of the brain revealed a small ring enhancing lesion in the right parietal lobe with adjacent meningeal thickening and enhancement. Surgical removal and histopathology showed evidence of severe chronic sterile inflammation and no malignant cell. Symptoms recurred and a lesion were again detected on radiological follow-up, but improvement occurred following treatment with antibiotics and biphosphonate, achieving a low inflammatory activity, reduction in CNS lesions and relative clinical well-being. This is a first report in literature about the central nervous system involvement in a patient with SAPHO syndrome.
Abul-Kasim
Kasim
K
Faculty of Medicine, Lund University, Diagnostic Centre for Imaging and Functional Medicine, Skåne University Hospital, 205 02, Malmö, Sweden. Kasim.Abul-Kasim@med.lu.se
Nilsson
Tomas
T
Turesson
Carl
C
D020083:Acquired Hyperostosis Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000601:surgery; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003399:Craniotomy; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008578:Meninges / Q000000981:diagnostic imaging / Q000473:pathology; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000473:pathology; D012008:Recurrence; D012640:Seizures / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D004164:Diphosphonates