Elevated blood markers 1 year before manifestation of malignant glioma.
We detected distinct plasma concentration profiles of S100B, neuropeptide Y, and secretagogin in 3 of 191 patients enrolled in a previous study investigating brain-tissue-related markers in the blood of patients with atrial fibrillation. Intriguingly, 2 of these 3 patients, both of whom were without neurological symptoms at the time of blood sampling, were diagnosed with malignant glioma (MG) approximately 1 year later. To our knowledge, this is the first report indicating that distinct blood biomarker profiles may be detected long before clinical manifestation of MG.
Gartner
Wolfgang
W
Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
Ilhan
Aysegül
A
Neziri
Dashurie
D
Base
Wolfgang
W
Weissel
Michael
M
Wöhrer
Adelheid
A
Heinzl
Harald
H
Waldhör
Thomas
T
Wagner
Ludwig
L
Preusser
Matthias
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D001932:Brain Neoplasms / Q000097:blood*; D002135:Calcium-Binding Proteins / Q000097:blood*; D005260:Female; D005910:Glioma / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D009478:Neuropeptide Y / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D064046:Secretagogins; D055815:Young Adult
D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D009414:Nerve Growth Factors; D009478:Neuropeptide Y; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; C576556:SCGN protein, human; D064046:Secretagogins