title: Positive association between plasma IGF1 and high-density lipoprotein cholesterol levels in adult nondiabetic subjects.
abstract: OBJECTIVE
  Low IGF1 levels have been associated with an increased cardiovascular risk. It is unknown however whether IGF1 mediates the atherosclerotic process by modulating high-density lipoprotein cholesterol (HDL-C) independently from confounders. To address this issue, we evaluated the association between IGF1 levels and HDL-C in nondiabetic subjects.
  
  
  METHODS
  A cross-sectional analysis was used in the context of the CAtanzaro MEtabolic RIsk factors Study. One thousand and four participants (aged 20-69 years), for whom HDL-C and IGF1 measurements were available, were eligible for the study.
  
  
  RESULTS
  After adjusting for gender and age, IGF1 levels were positively correlated with HDL-C, and negatively correlated with body mass index (BMI), waist circumference, blood pressure (BP), triglyceride, fasting insulin, and homeostasis model assessment (HOMA). In a logistic regression model adjusted for age and gender, IGF1 in the lowest tertile (<125 ng/ml) was associated with an increased risk of having low HDL-C (odds ratio (OR) 2.14, 95% confidence interval (CI) 1.4-3.0; P=4x10(-5)) compared with the highest tertile (>186 ng/ml). When BMI, waist circumference, total cholesterol, triglyceride, and HOMA index were added to the model, IGF1 remained significantly associated with increased risk of low HDL-C (OR 1.52, 95% CI 1.01-2.31; P=0.04). A stepwise multivariate regression analysis in a model including age, gender, BMI, total cholesterol, triglycerides, IGF1, HOMA, and BP showed that the variables significantly associated with HDL-C were gender (P<0.0001), triglycerides (P<0.0001), total cholesterol (P<0.0001), BMI (P<0.0001), IGF1 levels (P<0.0001), and HOMA (P=0.001), accounting for 32.6% of its variation.
  
  
  CONCLUSIONS
  These data provide evidence that IGF1 may be an independent modulator for HDL-C in nondiabetic individuals.
authors.affiliation: Department of Experimental and Clinical Medicine, University Magna-Graecia of Catanzaro, Via Europa, 88100 Catanzaro, Italy.
authors.forename: Elena
authors.initials: E
authors.lastname: Succurro
authors.forename: Franco
authors.initials: F
authors.lastname: Arturi
authors.forename: Alessandro
authors.initials: A
authors.lastname: Grembiale
authors.forename: Fiorella
authors.initials: F
authors.lastname: Iorio
authors.forename: Irma
authors.initials: I
authors.lastname: Laino
authors.forename: Francesco
authors.initials: F
authors.lastname: Andreozzi
authors.forename: Angela
authors.initials: A
authors.lastname: Sciacqua
authors.forename: Marta Letizia
authors.initials: ML
authors.lastname: Hribal
authors.forename: Francesco
authors.initials: F
authors.lastname: Perticone
authors.forename: Giorgio
authors.initials: G
authors.lastname: Sesti
mesh_terms: D000328:Adult; D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D055815:Young Adult
chemical_list: D008076:Cholesterol, HDL; D007334:Insulin-Like Growth Factor I