title: On-resin peptide macrocyclization using thiol-ene click chemistry.
abstract: A versatile and rapid synthetic strategy has been developed for the on-resin cyclization of peptides using thiol-ene photochemistry. This unique method exploits the thiol group of natural cysteine amino acids and allows for various alkenes to be incorporated orthogonal to the peptide backbone.
authors.affiliation: Department of Chemical & Biological Engineering, University of Colorado, Boulder, CO 80309, USA.
authors.forename: Alex A
authors.initials: AA
authors.lastname: Aimetti
authors.forename: Richard K
authors.initials: RK
authors.lastname: Shoemaker
authors.forename: Chien-Chi
authors.initials: CC
authors.lastname: Lin
authors.forename: Kristi S
authors.initials: KS
authors.lastname: Anseth
mesh_terms: D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003500:Cyclization; D003545:Cysteine / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D010777:Photochemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry*
chemical_list: D010456:Peptides, Cyclic; D013438:Sulfhydryl Compounds; D003545:Cysteine