title: CD86 +1057 G/A polymorphism and the risk of colorectal cancer.
abstract: CD86 (B7-2), one of the costimulatory molecules on antigen-presenting cells, plays essential roles not only in autoimmunity and transplantation but also in tumor immunity. The purpose of this study was to investigate whether CD86 gene polymorphism was involved in predisposing an individual to colorectal cancer (CRC). The CD86 +1057 G/A polymorphism was genotyped by performing polymerase chain reaction-restriction fragment length polymorphism in 273 patients with CRC and 292 healthy controls. There were significant differences in the genotype and allele distribution of +1057 G/A polymorphism of the CD86 gene between cases and controls. The +1057 AA genotype was associated with a significantly increased risk of CRC when compared with the GG genotype (odds ratio [OR] = 2.16; 95% confidence interval [CI], 1.31-3.58). Using the G allele as a reference, a significant correlation was detected between the presence of the A allele and a risk of developing CRC (OR = 1.42; 95% CI, 1.12-1.80). Interestingly, the A allele in female patients with CRC was significantly higher than that in male patients after stratified analysis (OR = 1.49; 95% CI, 1.04-2.14). These data suggest that CD86 +1057G/A polymorphism may contribute to genetic susceptibility to CRC in a Chinese population.
authors.affiliation: Department of Forensic Biology, Sichuan University, Chengdu, People's Republic of China.
authors.forename: Xin-Min
authors.initials: XM
authors.lastname: Pan
authors.forename: Lin-Bo
authors.initials: LB
authors.lastname: Gao
authors.forename: Wei-Bo
authors.initials: WB
authors.lastname: Liang
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
authors.forename: Ming
authors.initials: M
authors.lastname: Tang
authors.forename: Ying-Bi
authors.initials: YB
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000483:Alleles; D000938:Antigen-Presenting Cells / Q000473:pathology; D044466:Asian People / Q000235:genetics; D051940:B7-2 Antigen / Q000235:genetics*; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors
chemical_list: D051940:B7-2 Antigen