A new chemo-enzymatic route to chiral 2-hydroxy-4-phenylbutyrates by combining lactonase-mediated resolution with hydrogenation over Pd/C.
A new chemo-enzymatic route to both isomers of 2-hydroxy-4-phenylbutyric acid is reported. The key step is the lactonase-catalyzed hydrolysis of cis- and trans-2-hydroxy-4-phenyl-4-butyrolactones followed by hydrogenation over Pd/C to afford optically pure 2-hydroxy-4-phenylbutyric acid.
Chen
Bing
B
Laboratory of Biocatalysis and Bioprocessing, State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, PR China.
Yin
Hai-Feng
HF
Wang
Zhen-Sheng
ZS
Liu
Jia-Ying
JY
Xu
Jian-He
JH
D002244:Carbon / Q000737:chemistry*; D002265:Carboxylic Ester Hydrolases / Q000737:chemistry*; D002384:Catalysis; D006865:Hydrogenation; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010654:Phenylbutyrates / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
D010654:Phenylbutyrates; C078196:2-hydroxy-4-phenylbutyric acid; D010165:Palladium; D002244:Carbon; D002265:Carboxylic Ester Hydrolases; C019103:delta-lactonase