[Epileptic seizure-like effect of Sophora alkaloid sophoridine on experimental animals].
OBJECTIVE
To investigate the epileptic seizure-like effect of Sophora alkaloid sophoridine on electroencepholography (EEG) and its possible characteristic and the mechanism of the seizure-like effect.


METHODS
Chronic electron implantation was employed for the intracranial electroencepholography (IEEG) recording in rat, and the traditional anti-seizure drugs were for the mechanism study in mice.


RESULTS
Compared with the medial perforant path (PP) area and the temporal cortex (TC), the granule cells in hippocampus dentate gyrus (DG) area is more sensitive in the kindling effect by sc sophoridine. Under-threshold hypnotic dosage of diazepam and the hypnotic dosage of pentobarbital sodium can block the sophoridine kinded seizure in mice, but the phenytoin sodium can not block the seizure, also the dosage of it can block the maximal electroconvulsive shock (MES) seizure.


CONCLUSIONS
Sophoridine-induced synchronous oscillations in the hippocampus could elicit the generation and development of seizure. And the hippocampus might play the crucial role and be the original part of the seizure. Sophoridine kinded seizure might belong to clonic seizures, and the diazepam is the ideal agent for the treatment.
Peng
Xiaodong
X
Department of Pharmacology, School of Basic Medicine, Ningxia Medical University, Yinchuan 750004, China. pengxd@nxmu.edu.cn
Lu
Zhaogang
Z
Mu
Qingchun
Q
Hou
Yanhui
Y
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D004827:Epilepsy / Q000139:chemically induced* / Q000378:metabolism; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D011807:Quinolizines / Q000737:chemistry / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D029909:Sophora / Q000737:chemistry*; D000093842:Matrines
D000470:Alkaloids; D011807:Quinolizines; D000093842:Matrines