title: Flat detector CT in the evaluation of brain parenchyma, intracranial vasculature, and cerebral blood volume: a pilot study in patients with acute symptoms of cerebral ischemia.
abstract: OBJECTIVE
  The viability of both brain parenchyma and vascular anatomy is important in estimating the risk and potential benefit of revascularization in patients with acute cerebral ischemia. We tested the hypothesis that when used in conjunction with IV contrast, FD-CT imaging would provide both anatomic and physiologic information that would correlate well with that obtained by using standard multisection CT techniques.
  
  
  METHODS
  Imaging of brain parenchyma (FD-CT), cerebral vasculature (FD-CTA), and cerebral blood volume (FD-CBV) was performed in 10 patients. All patients also underwent conventional multisection CT, CTA, CTP (including CBV, CTP-CBV), and conventional catheter angiography. Correlation of the corresponding images was performed by 2 experienced neuroradiologists.
  
  
  RESULTS
  There was good correlation of the CBV color maps and absolute values between FD-CBV and CTP-CBV (correlation coefficient, 0.72; P < .001). The Bland-Altman test showed a mean difference of CBV values between FD-CT and CTP-CBV of 0.04 ± 0.55 mL/100 mL. All vascular lesions identified with standard CTA were also visualized with FD-CTA. Visualization of brain parenchyma by using FD-CT was poor compared with that obtained by using standard CT.
  
  
  CONCLUSIONS
  Both imaging of the cerebral vasculature and measurements of CBV by using FD-CT are feasible. The resulting vascular images and CBV measurements compared well with ones made by using standard CT techniques. The ability to measure CBV and also visualize cerebral vasculature in the angiography suite may offer significant advantages in the management of patients. FD-CT is not yet equivalent to CT for imaging of brain parenchyma.
authors.affiliation: Department of Neuroradiology, University of Erlangen-Nuremberg, Erlangen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Struffert
authors.forename: Y
authors.initials: Y
authors.lastname: Deuerling-Zheng
authors.forename: S
authors.initials: S
authors.lastname: Kloska
authors.forename: T
authors.initials: T
authors.lastname: Engelhorn
authors.forename: C M
authors.initials: CM
authors.lastname: Strother
authors.forename: W A
authors.initials: WA
authors.lastname: Kalender
authors.forename: M
authors.initials: M
authors.lastname: Köhrmann
authors.forename: S
authors.initials: S
authors.lastname: Schwab
authors.forename: A
authors.initials: A
authors.lastname: Doerfler
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D001810:Blood Volume; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging*; D002545:Brain Ischemia / Q000000981:diagnostic imaging*; D002533:Cerebral Angiography / Q000379:methods*; D002560:Cerebrovascular Circulation; D003287:Contrast Media; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media