title: Malignant minor salivary gland tumors: a retrospective study of 27 cases.
abstract: OBJECTIVE
  Malignant tumors of the intra-oral minor salivary glands are uncommon. The aim of this study was to give information concerning the clinical features of these tumors, the distribution of location, treatment opportunities, and outcome.
  
  
  METHODS
  Twenty-seven patients with malignant salivary gland tumors that were treated between January 1999 and December 2008 were evaluated retrospectively.
  
  
  RESULTS
  Of the 27 minor salivary gland carcinomas, 48.1% were adenoid cystic carcinomas (ACC), 29.7% mucoepidermoid carcinomas (MEC), 22.2% adenocarcinomas (ADCA). The most common first symptom was a painless swelling in 60% of the cases, with the second most common symptom being ulcers (28%). Four recurrences and two metastases were found. No recurrence was observed in ADCA. All four patients experiencing a recurrence developed it in the first 3 years after treatment.
  
  
  CONCLUSIONS
  Wide excision with a clinical margin of 1 cm and in large tumors, positive surgical margins or perineural infiltration and postoperative radiotherapy (RT) can be recommended; but in order to give exact information concerning the possible benefit from postoperative RT, it needs large prospective multicenter studies. Long-term follow-up controls and in particularly longer than 5 years in ACC including yearly chest X-rays should be offered to these patients because of late metastasis and recurrences.
authors.affiliation: Clinic for Cranio-Maxillofacial Surgery, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: Astrid L D
authors.initials: AL
authors.lastname: Kruse
authors.forename: Klaus W
authors.initials: KW
authors.lastname: Grätz
authors.forename: Joachim A
authors.initials: JA
authors.lastname: Obwegeser
authors.forename: Heinz-Theo
authors.initials: HT
authors.lastname: Lübbers
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000556:secondary; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000453:epidemiology / Q000556:secondary; D018277:Carcinoma, Mucoepidermoid / Q000453:epidemiology / Q000556:secondary; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D019226:Oral Ulcer / Q000453:epidemiology; D010157:Palatal Neoplasms / Q000453:epidemiology; D018714:Radiotherapy, Adjuvant / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000453:epidemiology*; D012470:Salivary Glands, Minor / Q000473:pathology*; D015996:Survival Rate; D013557:Switzerland / Q000453:epidemiology; D016896:Treatment Outcome