title: Solitary intradural extramedullary lymphoma of the cervical spine.
abstract: The authors report on the case of a 64-year-old man with solitary intradural extramedullary non-Hodgkin lymphoma of the cervical spine. The lesion mimicked the appearance of meningioma on MR imaging. Positron emission tomography showed increased accumulation of fluorine-18-labeled fluorodeoxyglucose only in the cervical lesion. Serum levels of C-reactive protein and soluble interleukin-2 receptor were mildly elevated. At surgery, the intradural tumor in the subarachnoid space was totally extirpated. Based on histopathological findings, diffuse, large B-cell type non-Hodgkin lymphoma was diagnosed. Postoperatively, the patient was treated with 2 courses of chemotherapy by intrathecal injection of methotrexate, cytarabine, and prednisolone and 4 courses of intravenous rituximab, an antibody binding to CD20 on the surface of B cells. All preoperative symptoms completely resolved after surgery. Two years postoperatively, the patient was faring well with no evidence of local recurrence or new lesions at any other site. To the best of the authors' knowledge, this case is the first reported instance of solitary intradural extramedullary non-Hodgkin lymphoma of the cervical spine.
authors.affiliation: Department of Orthopaedic Surgery, Kansai Rosai Hospital, Amagasaki, Hyogo 660-0064, Japan. tomoya43@hotmail.com
authors.forename: Tomoya
authors.initials: T
authors.lastname: Yamashita
authors.forename: Hironobu
authors.initials: H
authors.lastname: Sakaura
authors.forename: Kazuya
authors.initials: K
authors.lastname: Oshima
authors.forename: Motoki
authors.initials: M
authors.lastname: Iwasaki
authors.forename: Hideki
authors.initials: H
authors.lastname: Yoshikawa
mesh_terms: D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D058846:Antibodies, Monoclonal, Murine-Derived; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage; D002574:Cervical Vertebrae; D017024:Chemotherapy, Adjuvant; D003561:Cytarabine / Q000008:administration & dosage; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007275:Injections, Intravenous; D007278:Injections, Spinal; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011239:Prednisolone / Q000008:administration & dosage; D019275:Radiopharmaceuticals; D000069283:Rituximab; D013125:Spinal Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D019275:Radiopharmaceuticals; D003561:Cytarabine; D019788:Fluorodeoxyglucose F18; D000069283:Rituximab; D011239:Prednisolone; D008727:Methotrexate