Rigiflex lithography-based nanodot arrays for localized surface plasmon resonance biosensors.
We present a facile and robust means of fabricating metallic nanodot arrays for localized surface plasmon resonance (LSPR) biosensors through the strategic coupling of a polymeric template prepared with rigiflex lithography and a subsequent metallization via electrodeposition. Rigiflex lithography provides the capability to realize large-scale nanosized features as well as process flexibility during contact molding. In addition, the electrodeposition process enables wet-based nanoscale metallization with high pattern fidelity and geometric controllability. Generated metallic nanodot arrays can be used as a general platform for LSPR biosensors via the sequential binding of chemicals and biomolecules. Extinction spectra of the corresponding LSPR signal are measured with UV-vis-NIR spectroscopy, from which the pattern size and shape dependence of LSPR are readily confirmed. The feasibility of a very sensitive biosensor is demonstrated by the targeted binding of human immunoglobulin G, yielding subnanomolar detection capability with high selectivity.
Park
Dong Kyu
DK
School of Chemical Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
Kim
Hye In
HI
Kim
Jun Pyo
JP
Park
Je Seob
JS
Lee
Su Yeon
SY
Yang
Seung-Man
SM
Lee
Jeewon
J
Chung
Chan-Hwa
CH
Sim
Sang Jun
SJ
Yoo
Pil J
PJ
D000327:Adsorption; D004595:Electroplating; D006046:Gold / Q000737:chemistry; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D011093:Polyethylene Terephthalates / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D020349:Surface Plasmon Resonance / Q000295:instrumentation* / Q000379:methods*
D007074:Immunoglobulin G; D011093:Polyethylene Terephthalates; D011108:Polymers; D006046:Gold