Study of the triplet periodicity phase shifts in genes.
The definition of a phase shift of triplet periodicity (TP) is introduced. The mathematical algorithm for detection of TP phase shift of nucleotide sequences has been developed. Gene sequences from Kegg-46 data bank were analyzed with a purpose of searching genes with a phase shift of TP. The presence of a phase shift of triplet periodicity has been shown for 318329 genes (approximately 10% from the number of genes in Kegg-46). We suppose that shifts of the TP phase may indicate the shifts of reading frame (RF) in genes. A relationship between the phase shifts of TP and the frame shifts in genes is discussed.
Korotkov
Eugene V
EV
Bioinformatics laboratory, Centre of Bioengineering, Russian Academy of Sciences, Prospect 60-tya Oktyabrya 7/1, Moscow 117312, Russia. genekorotkov@gmail.com
Korotkova
Maria A
MA
D000465:Algorithms; D001419:Bacteria / Q000235:genetics; D001483:Base Sequence; D030541:Databases, Genetic; D005798:Genes, Bacterial / Q000235:genetics*; D016366:Open Reading Frames / Q000235:genetics; D010507:Periodicity; D017386:Sequence Homology, Amino Acid