title: TSH suppressive therapy: an overview of long-term clinical consequences.
abstract: An overview of long-term clinical consequences of TSH suppressive therapy provides evidence that serum TSH levels should be maintained at levels <0.1 mU/l in high-risk (stage III and IV) patients, whereas lower-risk patients should be allowed to have their TSH levels rise into the normal range after residual disease has been ruled out by imaging and/or stimulated thyroglobulin measurement. The proper management of patients with known residual thyroid cancer, who are also elderly or who have underlying serious comorbidities (e.g., osteoporosis, cardiovascular disease, diabetes), is uncertain and requires a high degree of clinical experience and judgment.
authors.affiliation: Division of Endocrinology and Metabolism, the Johns Hopkins University School of Medicine, Baltimore, USA. dscooper@jhmi.edu
authors.forename: David S
authors.initials: DS
authors.lastname: Cooper
mesh_terms: D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009367:Neoplasm Staging; D018365:Neoplasm, Residual; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D013954:Thyroglobulin / Q000097:blood; D013964:Thyroid Neoplasms / Q000150:complications / Q000188:drug therapy*; D016606:Thyroid Nodule / Q000150:complications / Q000188:drug therapy*; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000009:adverse effects* / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D013972:Thyrotropin; D013954:Thyroglobulin; D013974:Thyroxine