title: Transpedicular grafting after short-segment pedicle instrumentation for thoracolumbar burst fracture: calcium sulfate cement versus autogenous iliac bone graft.
abstract: METHODS
  A retrospective clinical and radiographic study was performed.
  
  
  OBJECTIVE
  To compare 2 grafting materials of anterior augmentation for thoracolumbar burst fractures: transpedicular cancellous bone (TPCB) grafting and transpedicular calcium sulfate grafting and to decide whether calcium sulfate cement can replace autogenous cancellous bone applied in anterior vertebral body augmentation after posterior short-segment instrumentation.
  
  
  BACKGROUND
  Additional TPCB grafting was developed as an alternative to prevent early implant failure. However, the results are inconsistent and donor-site complications are a major concern. Calcium sulfate has been offered as a bone substitute for treating patients with metaphysis fractures or bone defect, but the results of application in spinal surgeries are uncertain.
  
  
  METHODS
  Fifty-one patients with a single-level thoracolumbar burst fracture for treatment with short-segment pedicle screw fixation were enrolled in the study. Fractures in group 1 patients were reinforced with TPCB (n = 31), and fractures in group 2 patients were augmented with transpedicular calcium sulfate cement (TPCSC; n = 20). All patients were followed-up at least 2 years after surgery. Radiographic parameters and clinical outcomes were compared between the 2 groups.
  
  
  RESULTS
  The 2 groups were similar in age, sex, fracture levels, preoperative neurologic status distribution, and the associated injuries. The TPCB group had a longer period of follow-up (52.7 +/- 4.9 vs. 28.6 +/- 3.5 months, P < 0.001). Blood loss and operation time were less in the TPCSC group (247.5 +/- 164.2 vs. 600.0 +/- 403.1 mL, P = 0.001 and 161.7 +/- 28.5 vs. 227.2 +/- 43.6 minutes, P < 0.001). Radiographic parameters and clinical outcomes were similar in both groups. The TPCSC group had no surgical complication, but the TPCB group revealed 2 cases with wound infection after surgery. The failure rate, defined as an increase of 10 degrees or more in loss of correction or implant failure, was also not significantly different (TPCB = 9.6% and TPCSC = 15%; P = 0.565). All patients with partial neurologic deficits initially improved at the final follow-up.
  
  
  CONCLUSIONS
  Additional TPCB grafting after posterior short-segment instrumentation remains a reliable surgical method for correcting and maintaining sagittal alignment and vertebral body height in thoracolumbar burst fractures. Calcium sulfate cement also proved to be an effective bone substitute used in spinal surgeries for patients with thoracolumbar burst fractures.
authors.affiliation: Department of Orthopedics Surgery, Chang Gung Memorial Hospital, Chang Gung University, Kweishian, Taoyuan, Taiwan. jcl1265@adm.cgmh.org.tw
authors.forename: Jen-Chung
authors.initials: JC
authors.lastname: Liao
authors.forename: Kuo-Fon
authors.initials: KF
authors.lastname: Fan
authors.forename: Gun
authors.initials: G
authors.lastname: Keorochana
authors.forename: Wen-Jer
authors.initials: WJ
authors.lastname: Chen
authors.forename: Lih-Hui
authors.initials: LH
authors.lastname: Chen
mesh_terms: D000328:Adult; D001843:Bone Cements / Q000627:therapeutic use; D001863:Bone Screws; D016025:Bone Transplantation / Q000379:methods*; D002133:Calcium Sulfate / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D005593:Fracture Fixation, Internal / Q000295:instrumentation / Q000379:methods; D006801:Humans; D007085:Ilium / Q000637:transplantation; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016103:Spinal Fractures / Q000601:surgery*; D013904:Thoracic Vertebrae / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D001843:Bone Cements; D002133:Calcium Sulfate