Adipose tissue lipolysis revisited (again!): lactate involvement in insulin antilipolytic action.
Lactate is produced from glucose by adipose tissue. In this issue of Cell Metabolism, Ahmed et al. (2010) show that the metabolite is involved in the antilipolytic effect of insulin, providing a new link between fat and carbohydrate metabolism.
Langin
Dominique
D
Inserm U858, Obesity Research Laboratory, Rangueil Institute of Molecular Medicine, Toulouse F-31432, France. dominique.langin@inserm.fr
D000273:Adipose Tissue / Q000378:metabolism / Q000502:physiology*; D007328:Insulin / Q000378:metabolism*; D019344:Lactic Acid / Q000378:metabolism*; D008066:Lipolysis / Q000502:physiology*; D008954:Models, Biological
D007328:Insulin; D019344:Lactic Acid