title: [Therapeutic effect of emodin in experimental periodonititis rats].
abstract: OBJECTIVE
  Through observing the change of Nitric Oxide (NO) in the peripheral blood and gingival tissue, to explore the mechanism of Emodin (EMD) in the therapy of periodontal disease.
  
  
  METHODS
  SD rats were randomly divided into four groups of thirty (group N, group P, group PL and the group PH). The periodontitis model was made and EMD was administered at PL and PH. At the 4th, 6th, 8th weeks after the animal models were established, the rats were killed respectively and the maxilla and the peripheral blood were collected. A side of maxilla was stained with HE for histological examination and the other side of gingival tissue surround ligated tooth was collected for the measurement of NO. Also, it was measured in the peripheral blood. GLM method using SPSS was used to compare changes in each of the variables over time.
  
  
  RESULTS
  The levels of NO in the peripheral blood and gingival tissue in PL and PH groups were significantly lower than that in P groups(P<0.05).
  
  
  CONCLUSIONS
  Emodin can take effect on periodontitis by reducing the levels of NO in the peripheral blood and gingival tissue.
authors.affiliation: Department of Oral Medicine, The Stomatologic Hospital of Hebei Medical University, Shijiazhuang 050017, China. bingren1975@sina.com
authors.forename: Bing
authors.initials: B
authors.lastname: Liu
authors.forename: Shu-juan
authors.initials: SJ
authors.lastname: Li
authors.forename: Dong-ru
authors.initials: DR
authors.lastname: Yang
authors.forename: Fu-sheng
authors.initials: FS
authors.lastname: Dong
authors.forename: Xiang-he
authors.initials: XH
authors.lastname: Huang
authors.forename: Tao
authors.initials: T
authors.lastname: Li
mesh_terms: D000818:Animals; D004642:Emodin / Q000494:pharmacology* / Q000627:therapeutic use*; D005260:Female; D005881:Gingiva / Q000187:drug effects / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism; D010510:Periodontal Diseases / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D013997:Time Factors
chemical_list: D009569:Nitric Oxide; D004642:Emodin