title: Platelet-rich fibrin matrix for improvement of deep nasolabial folds.
abstract: BACKGROUND
  Dermal augmentation continues to grow as an aesthetic facial procedure. Many exogenous filler materials rely on an autologous fibrotic response for volume augmentation.
  
  
  OBJECTIVE
  To evaluate the efficacy of a single injection of autologous platelet-rich fibrin matrix (PRFM) for the correction of deep nasolabial folds (NLFs).
  
  
  METHODS
  Whole blood was obtained from 15 adults, and an activated autologous PRFM produced using a proprietary system (Selphyl; Aesthetic Factors, Inc., Wayne, NJ, USA) was then injected into the dermis and immediate subdermis below the NLFs. Subjects were photographed before and after treatment; NLFs were rated by the treating physician before and after treatment using the Wrinkle Assessment Scale (WAS) and patients rated their appearance at each post-treatment visit using the Global Aesthetic Improvement Scale. Patients were evaluated at 1, 2, 6, and 12 weeks after treatment.
  
  
  RESULTS
  All patients were treated to maximal (no over-) correction, with a mean reduction in WAS score of 2.12 +/- 0.56. At 1 week after treatment, this difference was 0.65 +/- 0.68, but rose to 0.97 +/- 0.75, 1.08 +/- 0.59, and 1.13 +/- 0.72 at 2, 6, and 12 weeks after treatment, respectively (P < 0.001). No patient noted any fibrosis, irregularity, hardness, restricted movement, or lumpiness.
  
  
  CONCLUSIONS
  PRFM can provide significant long-term diminution of deep NLFs without the use of foreign materials. PRFM holds significant potential for stimulated dermal augmentation.
authors.affiliation: Division of Facial Plastic Surgery, The New York Eye & Ear Infirmary, New York, New York 10003, USA. asclafani@nyee.edu
authors.forename: Anthony P
authors.initials: AP
authors.lastname: Sclafani
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D006801:Humans; D007271:Injections, Intradermal; D007279:Injections, Subcutaneous; D008046:Lip; D008297:Male; D008875:Middle Aged; D009666:Nose; D053657:Platelet-Rich Plasma; D012060:Rejuvenation; D015595:Skin Aging; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D005337:Fibrin