title: Microheater based on magnetic nanoparticle embedded PDMS.
abstract: A microheater was established by embedding magnetic nanoparticles into PDMS (MNP-PDMS). MNP-PDMS generated heat under an AC magnetic field and the temperature was controlled by varying the magnetic particle content and the magnetic field intensity. In this study, the MNP-PDMS chip was demonstrated to amplify the target DNA (732 bp) with > 90% efficiency compared to the conventional PCR thermocycler, and exhibited good performance in regards to temperature control. This system holds great promise for reliably controlling the temperature of thermal processes on an integrated microchip platform for biochemical applications.
authors.affiliation: School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744, Korea.
authors.forename: Jeong Ah
authors.initials: JA
authors.lastname: Kim
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Lee
authors.forename: Hongsuk
authors.initials: H
authors.lastname: Park
authors.forename: Jong Hyo
authors.initials: JH
authors.lastname: Kim
authors.forename: Tai Hyun
authors.initials: TH
authors.lastname: Park
mesh_terms: D004129:Dimethylpolysiloxanes / Q000737:chemistry*; D004574:Electromagnetic Fields; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006361:Heating / Q000295:instrumentation*; D008280:Magnetics / Q000295:instrumentation*; D008904:Miniaturization; D053758:Nanoparticles / Q000737:chemistry* / Q000528:radiation effects*; D036103:Nanotechnology / Q000295:instrumentation*
chemical_list: D004129:Dimethylpolysiloxanes; C013830:baysilon