Nuclear xenobiotic receptors: integrating gene regulation to physiological functions.
Nuclear receptors (NRs) belong to a superfamily of evolutionarily related DNA-binding transcription factors that can be activated by steroid and thyroid hormones, and other lipid metabolites. Ligand activated NRs can regulate target gene expression by binding to DNA response elements present in the target gene promoters. Through this regulation, NRs are broadly implicated in physiology and metabolism. In this chapter, we will focus on the more recently identified and characterized xenobiotic receptors and their functions in xeno- and endobiotic responses.
He
Jinhan
J
Center for Pharmacogenetics and Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania 15216, USA.
Xie
Wen
W
D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D008024:Ligands; D010829:Physiological Phenomena / Q000235:genetics*; D017434:Protein Structure, Tertiary; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry / Q000378:metabolism*; D015262:Xenobiotics / Q000378:metabolism*
D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; D015262:Xenobiotics