The diagnostic value of beta-human chorionic gonadotropin, progesterone, CA125 in the prediction of abortions.
This study was conducted to investigate the effectiveness of serum levels of free beta-hCG, progesterone, CA125 and their combined use in the prediction of first trimester abortions. A total of 140 singleton pregnant women between 5 and 13 weeks' gestational age were included as Group I (n = 21) who resulted in abortion including missed abortion, incomplete abortion, complete abortion and inevitable abortion; Group II (n = 129) included normal pregnancies. When using the free beta-hCG level of <20 ng/ml as a cut off point, the sensitivity, specificity, PPV and NPV were 91%, 82%, 46% and 98%, when using a progesterone of <15 ng/ml as a cut off point, they were 91%, 89%, 59%, 98%. The single measurement of free beta-hCG or progesterone levels can be useful in the prediction of first trimester spontaneous abortions, but using progesterone may be recommended since it has high availability and low cost.
Osmanağaoğlu
M A
MA
Department of Obstetrics and Gynecology, Karadeniz Technical University, Trabzon, Turkey. drmaosmanaga@gmail.com
Erdoğan
I
I
Eminağaoğlu
S
S
Karahan
S C
SC
Ozgün
S
S
Can
G
G
Bozkaya
H
H
D000022:Abortion, Spontaneous / Q000175:diagnosis*; D000328:Adult; D018394:CA-125 Antigen / Q000097:blood*; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood*; D005260:Female; D006801:Humans; D007118:Immunoassay / Q000191:economics / Q000379:methods; D016015:Logistic Models; D008565:Membrane Proteins / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011374:Progesterone / Q000097:blood*; D011446:Prospective Studies; D014421:Turkey; D055815:Young Adult
D018394:CA-125 Antigen; D018997:Chorionic Gonadotropin, beta Subunit, Human; C451759:MUC16 protein, human; D008565:Membrane Proteins; D011374:Progesterone