title: Palatinose-blended sugar compared with sucrose: different effects on insulin sensitivity after 12 weeks supplementation in sedentary adults.
abstract: BACKGROUND
  We investigated the effects of daily palatinose intake on the risk factors of metabolic syndrome in sedentary non-obese Japanese adults.
  
  
  METHODS
  Japanese adults (40 females and 10 males, age: 53 +/- 9 years, range: 31-72 years old) were randomized into two groups for a double-blind, placebo-controlled intervention study and given either 40 g/day palatinose-blended sugar (PS group) or 40 g/day sucrose (S group) in their diet for 12 weeks.
  
  
  RESULTS
  After the intervention, the insulin resistance index (HOMA-IR) had significantly decreased only in the PS group; the inter-group difference was significant at P = 0.006. Although the S group showed a significant increase in the leptin concentration and the systolic blood pressure, the PS group showed no significant changes; the inter-group differences were significant at P = 0.018 and P = 0.037, respectively.
  
  
  CONCLUSIONS
  Palatinose intake possibly improves insulin sensitivity when compared with sucrose intake.
authors.affiliation: Research Laboratory, Mitsui Sugar Co., Ltd, Chigasaki, Kanagawa, Japan. masahiro.okuno@mitsui-sugar.co.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okuno
authors.forename: Maeng-Kyu
authors.initials: MK
authors.lastname: Kim
authors.forename: Masami
authors.initials: M
authors.lastname: Mizu
authors.forename: Mari
authors.initials: M
authors.lastname: Mori
authors.forename: Hideki
authors.initials: H
authors.lastname: Mori
authors.forename: Yukio
authors.initials: Y
authors.lastname: Yamori
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D019422:Dietary Sucrose / Q000008:administration & dosage / Q000494:pharmacology*; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D007534:Isomaltose / Q000031:analogs & derivatives* / Q000494:pharmacology; D020738:Leptin / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000517:prevention & control*; D008875:Middle Aged; D012307:Risk Factors; D057185:Sedentary Behavior; D013395:Sucrose / Q000494:pharmacology*
chemical_list: D019422:Dietary Sucrose; D020738:Leptin; D013395:Sucrose; D007534:Isomaltose; C008189:isomaltulose