title: [Primary ovarian malignant melanoma].
abstract: BACKGROUND
  Primary ovarian malignant melanoma is extremely rare. It usually appears in the wall of a dermoid cyst or is associated with another teratomatous component. Metastatic primary malignant melanoma to ovary from a primary melanoma elsewhere is well known and has been often reported especially in autopsy studies.
  
  
  METHODS
  We presented a case of primary ovarian malignant melanoma in a 45-year old woman, with no evidence of extraovarian primary melanoma nor teratomatous component. The tumor was unilateral, macroscopically on section presented as solid mass, dark brown to black color. Microscopically, tumor cells showed positive immunohistochemical reaction for HMB-45, melan-A and S-100 protein, and negative immunoreactivity for estrogen and progesteron receptors.
  
  
  CONCLUSIONS
  Differentiate metastatic melanoma from rare primary ovarian malignant melanoma, in some of cases may be a histopathological diagnostic problem. Histopathological diagnosis of primary ovarian malignant melanoma should be confirmed by immunohistochemical analyses and detailed clinical search for an occult primary tumor.
authors.affiliation: Vojna bolnica, Odsek za patoloiku anatomiju, Nis, Srbija. kolepath@bankerinter.net
authors.forename: Milos
authors.initials: M
authors.lastname: Kostov
authors.forename: Biserka
authors.initials: B
authors.lastname: Vukomanović-Djurdjević
authors.forename: Dane
authors.initials: D
authors.lastname: Nenadić
authors.forename: Milos
authors.initials: M
authors.lastname: Pavlović
mesh_terms: D005260:Female; D006801:Humans; D008545:Melanoma / Q000473:pathology*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology*