title: Organochlorine pesticides in colostrums in case of normal and preterm labor (Iasi, Romania).
abstract: Assessment of organochlorine pesticides (OCPs) in human body is important for human health because they have weak estrogenic or antiestrogenic effects and are considered endocrine disrupters. We used colostrum of women as indicator for levels of OCPs in human body for mothers with normal and preterm labor from eastern part of Romania. Sixty- three samples of colostrum were extracted by solid-phase extraction. Analyses were carried out using gas chromatography coupled to mass spectrometry (GC-MS). OCPs have been detected in all samples, with p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) and gamma-hexachlorocyclohexane (gamma-HCH) being at the highest concentrations. Of the organochlorines measured in clostrum samples from women in preterm labor, median levels of DDTs (470 ng/g) and HCHs (99 ng/g) were higher than for the same compounds from women in normal labor (median of DDTs=268 ng/g and median of HCHs=96 ng/g). Normal labor had higher median concentrations of HCB (19.5 ng/g) versus preterm labor (14 ng/g). Statistical data show high Spearman correlation coefficients between various OCPs. We found a good correlation between alpha-, gamma-, beta- and delta- HCH isomers (p<0.001) for both normal and preterm labor. The most abundant target compound was p,p'-DDE (median value 96 ng/g, and 137 ng/g for mother with normal and preterm labor, respectively) in all colostrum samples. The estimated daily intakes of HCHs by infants exceeded corresponding Health Canada guidelines.
authors.affiliation: Department of Chemistry, Al. I. Cuza University of Iasi, Boulevard Carol. I 11, Iasi, Romania. mona.cioroiu@ymail.com
authors.forename: Mona
authors.initials: M
authors.lastname: Cioroiu
authors.forename: Doina
authors.initials: D
authors.lastname: Tarcau
authors.forename: Raluca
authors.initials: R
authors.lastname: Mocanu
authors.forename: Simona
authors.initials: S
authors.lastname: Cucu-Man
authors.forename: Bogdan
authors.initials: B
authors.lastname: Nechita
authors.forename: Maria
authors.initials: M
authors.lastname: Luca
mesh_terms: D000293:Adolescent; D000328:Adult; D003126:Colostrum / Q000378:metabolism*; D003634:DDT / Q000378:metabolism; D003633:Dichlorodiphenyl Dichloroethylene / Q000378:metabolism; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000378:metabolism*; D062665:Epidemiological Monitoring; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D006581:Hexachlorobenzene / Q000378:metabolism; D001556:Hexachlorocyclohexane / Q000378:metabolism; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000378:metabolism*; D007743:Labor, Obstetric / Q000378:metabolism*; D018811:Maternal Exposure / Q000706:statistics & numerical data; D007752:Obstetric Labor, Premature / Q000453:epidemiology / Q000378:metabolism*; D010573:Pesticide Residues / Q000378:metabolism*; D011247:Pregnancy; D018570:Risk Assessment; D012383:Romania / Q000453:epidemiology; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D004967:Estrogens; D006843:Hydrocarbons, Chlorinated; D010573:Pesticide Residues; D003633:Dichlorodiphenyl Dichloroethylene; D006581:Hexachlorobenzene; D001556:Hexachlorocyclohexane; D003634:DDT