title: Diversity-oriented construction of highly substituted indolizinones.
abstract: Rapid generation of a small library of highly functionalized indolizonones was realized by exploiting three palladium-catalyzed cross-coupling reactions of 2-iodoindolizinones which in turn were readily accessed via sequential iodine-mediated cyclization/1,2-shift reactions of propargylic alcohols.
authors.affiliation: Medicinal Chemistry Research Center, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea.
authors.forename: Kyungsun
authors.initials: K
authors.lastname: Kim
authors.forename: Ikyon
authors.initials: I
authors.lastname: Kim
mesh_terms: D000480:Alkynes / Q000737:chemistry; D002384:Catalysis; D003432:Cross-Linking Reagents / Q000737:chemistry; D003500:Cyclization; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry; D008956:Models, Chemical; D010165:Palladium / Q000737:chemistry; D020005:Propanols / Q000737:chemistry; D054852:Small Molecule Libraries
chemical_list: D000480:Alkynes; D003432:Cross-Linking Reagents; D007212:Indolizines; D020005:Propanols; D054852:Small Molecule Libraries; D010165:Palladium; D007455:Iodine; C028255:propargyl alcohol