title: Asymmetric total synthesis of the caspase-1 inhibitor (-)-berkeleyamide A.
abstract: The asymmetric total synthesis of (-)-berkeleyamide A (1), a naturally occurring caspase-1 inhibitor, has been achieved by employing Evans' syn-aldol reaction of N-acyl-(4R)-benzyl oxazolidin-2-one 3 as the key step.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.
authors.forename: Swapnil J
authors.initials: SJ
authors.lastname: Kulkarni
authors.forename: Yakambram
authors.initials: Y
authors.lastname: Pedduri
authors.forename: Amar G
authors.initials: AG
authors.lastname: Chittiboyina
authors.forename: Mitchell A
authors.initials: MA
authors.lastname: Avery
mesh_terms: D061945:Caspase Inhibitors; D002384:Catalysis; D015394:Molecular Structure; D023303:Oxazolidinones / Q000737:chemistry; D011480:Protease Inhibitors / Q000138:chemical synthesis*; D011760:Pyrrolidinones / Q000138:chemical synthesis*
chemical_list: D061945:Caspase Inhibitors; D023303:Oxazolidinones; D011480:Protease Inhibitors; D011760:Pyrrolidinones; C547261:berkeleyamide A