title: Effect of losartan on vascular function in fructose-fed rats: the role of perivascular adipose tissue.
abstract: Recent studies have shown the effect of perivascular adipose tissue (PVAT) on the regulation of vascular function; however, its role in the model of metabolic syndrome remains unclear. The aim of this study was to examine the effect of losartan on PVAT-derived vascular dysfunction in fructose-induced hypertensive rats. Rats were fed with either water, 10% fructose, or 10% fructose with 10mg/kg losartan for 8 weeks. In the isolated aorta with PVAT and endothelium, contraction induced by norepinephrine (NE) was more potent in fructose-fed rats compared to control rats. Losartan normalized blood pressure, insulin resistance, and NE-induced vasoconstriction in fructose-fed rats. In the aortic rings with/without endothelium and with/without PVAT, losartan could not improve the acetylcholine-induced relaxation in fructose-fed rats. The observation suggested that losartan partly improved the PVAT-associated vascular regulation in fructose-induced hypertensive rats.
authors.affiliation: Department of Pharmacology and Toxicology, Hospital Infantil de México Federico Gómez, México.
authors.forename: Fengyang
authors.initials: F
authors.lastname: Huang
authors.forename: Miguel Angel Rosas
authors.initials: MA
authors.lastname: Lezama
authors.forename: José Alfredo Pérez
authors.initials: JA
authors.lastname: Ontiveros
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Bravo
authors.forename: Santiago
authors.initials: S
authors.lastname: Villafaña
authors.forename: Blanca Estela
authors.initials: BE
authors.lastname: del-Rio-Navarro
authors.forename: Enrique
authors.initials: E
authors.lastname: Hong
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000273:Adipose Tissue / Q000187:drug effects* / Q000503:physiopathology*; D047228:Angiotensin II Type 1 Receptor Blockers / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000503:physiopathology*; D004195:Disease Models, Animal; D005632:Fructose / Q000633:toxicity; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology*; D019808:Losartan / Q000494:pharmacology*; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000150:complications / Q000503:physiopathology; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
chemical_list: D047228:Angiotensin II Type 1 Receptor Blockers; D005632:Fructose; D019808:Losartan; D000109:Acetylcholine; D009638:Norepinephrine