title: Novel bioactive scaffolds incorporating nanogels as potential drug eluting devices.
abstract: Big advances are being achieved in the design of new implantable devices with enhanced properties. For example, synthetic porous three-dimensional structures can mimic the architecture of the tissues, and serve as templates for cell seeding. In addition, polymeric nanoparticles are able to provide a programmable and sustained local delivery of different types of biomolecules. In this study novel alternative scaffolds with controlled bioactive properties and architectures are presented. Two complementary approaches are described. Firstly, scaffolds with nanogels as active controlled release devices incorporated inside the three-dimensional structure are obtained using the thermally induced phase separation (TIPS) method. Secondly, a novel coating method using the spraying technique to load these nanometric crosslinked hydrogels on the surface of two-dimensional (2D) and three-dimensional (3D) biodegradable scaffolds is described. The scanning electron microscopy (SEM) images show the distribution of the nanogels on the surface of different substrates and also inside the porous structure of poly-alpha-hydroxy ester derivative foams. Both of them are compared in terms of manufacturability, dispersion and other processing variables.
authors.affiliation: INASMET-TECNALIA, Mikeletegi Pasealekua, 2, Parque Tecnológico, Donostia-San Sebastian, E-20009, Spain; Ciber-BBN, San Sebastian, E-20009, Spain.
authors.forename: Virginia
authors.initials: V
authors.lastname: Saez-Martinez
authors.forename: Beatriz
authors.initials: B
authors.lastname: Olalde
authors.forename: Maria Jesus
authors.initials: MJ
authors.lastname: Juan
authors.forename: Maria Jesus
authors.initials: MJ
authors.lastname: Jurado
authors.forename: Nerea
authors.initials: N
authors.lastname: Garagorri
authors.forename: Isabel
authors.initials: I
authors.lastname: Obieta
mesh_terms: D000042:Absorption; D001672:Biocompatible Materials / Q000737:chemistry*; D003460:Crystallization / Q000379:methods*; D004339:Drug Compounding / Q000379:methods; D004343:Drug Implants / Q000737:chemistry*; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D000080385:Nanogels; D050997:Nanomedicine / Q000379:methods*; D049329:Nanostructures / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D011091:Polyesters; D011092:Polyethylene Glycols / Q000737:chemistry*; D011094:Polyethyleneimine / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D004343:Drug Implants; D000080385:Nanogels; D011091:Polyesters; D011108:Polymers; C413692:polyethylene glycol polyethyleneimine nanogel; D019344:Lactic Acid; D011092:Polyethylene Glycols; C033616:poly(lactide); D011094:Polyethyleneimine