title: Immunogenicity of three different influenza vaccines against homologous and heterologous strains in nursing home elderly residents.
abstract: We studied whether MF59-adjuvanted influenza vaccine improves immunity against drifted influenza strains in institutionalised elderly with underling chronic health conditions. Sera from a randomized study, comparing MF59-adjuvanted (Sub/MF59, n = 72), virosomal (SVV, n = 39), and split (n = 88) vaccines, were retested using a hemagglutination inhibition (HI) assay against homologous (Northern Hemisphere [NH] 1998/99) and drifted (NH 2006/07) strains. Corrected postvaccination HI antibody titres were significantly higher with Sub/MF59 than SVV for all strains; GMTs against homologous A/H3N2 and B and both drifted A strains were significantly higher for Sub/MF59 than split. Seroprotection rates and mean-fold titer increases were generally higher with Sub/MF59 for all A influenza strains. MF59-adjuvanted influenza vaccine induced greater and broader immune responses in elderly people with chronic conditions, than conventional virosomal and split vaccines, particularly for A/H1 and A/H3 strains, potentially giving clinical benefit in seasons where antigenic mismatch occurs.
authors.affiliation: Department of Environmental Medicine and Public Health, Institute of Hygiene, University of Padua, Via loredan 18, 35151 Padua, Italy. vincenzo.baldo@unipd.it
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Baldo
authors.forename: Tatjana
authors.initials: T
authors.lastname: Baldovin
authors.forename: Michele
authors.initials: M
authors.lastname: Pellegrini
authors.forename: Gabriele
authors.initials: G
authors.lastname: Angiolelli
authors.forename: Silvia
authors.initials: S
authors.lastname: Majori
authors.forename: Annarosa
authors.initials: A
authors.lastname: Floreani
authors.forename: Marta Cecilia
authors.initials: MC
authors.lastname: Busana
authors.forename: Chiara
authors.initials: C
authors.lastname: Bertoncello
authors.forename: Renzo
authors.initials: R
authors.lastname: Trivello
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D056724:Immunity, Humoral; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000097:blood / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control; D007558:Italy; D008297:Male; D009735:Nursing Homes; D009975:Orthomyxoviridae / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D010802:Phylogeny; D013045:Species Specificity; D014611:Vaccination
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D007252:Influenza Vaccines