title: Mild asthma in overweight women: A new phenotype?
abstract: BACKGROUND
  Epidemics of asthma and overweight have been linked recently. They might be associated with systemic inflammation. In asthma hyperresponsiveness to adenosine (AMP) is more closely related to inflammation than to methacholine (MCh). The aim of the study was to determine responsiveness to AMP and MCh in overweight compared with normal weight asthmatics.
  
  
  METHODS
  Thirty women were enrolled (19 overweight) with mild controlled asthma according to GINA. A Body Mass Index (BMI) less than 25kg/m(2) was considered as normal and a BMI above 25kg/m(2) as overweight. We assessed the recent control of asthma (ACQ), pulmonary function tests, bronchial responsiveness to MCh and AMP (PC(20) and O'Connor two-point dose-response slope), perception of symptoms (Borg scale), and blood inflammatory markers (leptin and hs-CRP by ELISA).
  
  
  RESULTS
  Overweight had a significant lower dose-response slope of the MCh challenge (p=0.009) as compared to normal weight patients, whereas no significant difference was observed for AMP challenge (p=0.27). Overweight patients had higher intercepts of the Borg scale measured before the MCh and AMP challenge tests (p=0.01 and p=0.03). Plasma leptin (p=0.001) and hs-CRP (p=0.05) concentrations were higher in overweight than normal weight patients. There was no correlation between challenges and inflammatory markers.
  
  
  CONCLUSIONS
  Overweight asthmatic women have more pronounced systemic inflammation, but are less responsive to MCh. AMP responsiveness appeared to be comparable between both groups. Our findings suggest that overweight asthmatic women do not feature increased airway inflammation, but do represent a distinct phenotype as compared to normal weight patients.
authors.affiliation: CHU-Montpellier, Respiratory Department, Hôpital Arnaud de Villeneuve, 371 av doyen Gaston Giraud, 34295 Montpellier Cx 5, France.
authors.forename: Marissa
authors.initials: M
authors.lastname: Engbers
authors.forename: Isabelle
authors.initials: I
authors.lastname: Vachier
authors.forename: Peter
authors.initials: P
authors.lastname: Sterk
authors.forename: Arnaud
authors.initials: A
authors.lastname: Bourdin
authors.forename: Delphine
authors.initials: D
authors.lastname: Gras
authors.forename: Philippe
authors.initials: P
authors.lastname: Godard
authors.forename: Pascal
authors.initials: P
authors.lastname: Chanez
mesh_terms: D000249:Adenosine Monophosphate / Q000235:genetics; D000328:Adult; D000368:Aged; D001249:Asthma / Q000175:diagnosis* / Q000235:genetics; D015992:Body Mass Index; D016085:Bronchoconstrictor Agents; D005260:Female; D006801:Humans; D016210:Methacholine Chloride; D008875:Middle Aged; D050177:Overweight / Q000503:physiopathology*; D010641:Phenotype; D012129:Respiratory Function Tests; D011795:Surveys and Questionnaires
chemical_list: D016085:Bronchoconstrictor Agents; D016210:Methacholine Chloride; D000249:Adenosine Monophosphate