title: Efficacy of terbinafine compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis in a guinea pig model.
abstract: The in vivo efficacy of terbinafine was compared to lanoconazole and luliconazole in the topical treatment of dermatophytosis caused by Trichophyton mentagrophytes using a guinea pig model. Topical antifungal treatment commenced three days post-infection, and each agent was applied once daily for seven consecutive days. Upon completion of the treatment period, evaluations of clinical and mycological efficacies were performed, as was scanning electron microscopy (SEM) analyses. Data showed that while all tested antifungals demonstrated significant mycological efficacy in terms of eradicating the fungi over untreated control, terbinafine and luliconazole showed superior clinical efficacy compared to lanoconazole (P-values < 0.001 & 0.003, respectively). Terbinafine demonstrated the highest clinical percent efficacy. SEM analysis revealed hairs from terbinafine and lanoconazole-treated animals had near complete clearance of fungi, while samples from luliconazole-treated animals were covered with debris and few conidia. This study demonstrates that, in general, terbinafine possessed similar efficacy to lanoconazole and luliconazole in the treatment of dermatophytosis. Terbinafine tended to have superior clinical efficacy compared to the azoles tested, although this difference was not statistically significant against luliconazole. This apparent superiority may be due to the fungicidal activity of terbinafine compared to the fungistatic effect of the other two drugs.
authors.affiliation: Center for Medical Mycology, Case Western Reserve University School of Medicine and University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106-5028, USA. mag3@case.edu
authors.forename: M A
authors.initials: MA
authors.lastname: Ghannoum
authors.forename: L
authors.initials: L
authors.lastname: Long
authors.forename: H G
authors.initials: HG
authors.lastname: Kim
authors.forename: A J
authors.initials: AJ
authors.lastname: Cirino
authors.forename: A R
authors.initials: AR
authors.lastname: Miller
authors.forename: P
authors.initials: P
authors.lastname: Mallefet
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003881:Dermatomycoses / Q000188:drug therapy*; D004195:Disease Models, Animal; D006168:Guinea Pigs; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D000077291:Terbinafine; D016896:Treatment Outcome; D014249:Trichophyton / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D009281:Naphthalenes; C072774:latoconazole; D000077291:Terbinafine; C112528:luliconazole