title: Lifetime manic-hypomanic symptoms in post-traumatic stress disorder: relationship with the 18 kDa mitochondrial translocator protein density.
abstract: Initially explored in military settings, post-traumatic stress disorder (PTSD) has shown increasing prevalence in the general population. The high comorbidity rates between bipolar disorder (BD) and PTSD have raised the issue of whether some characteristics of BD could represent risk factors for PTSD. In combat-related PTSD, the 18 kDa mitochondrial translocator protein (TSPO), essential for steroid synthesis, was found to be decreased. Aims of the present study were: 1) the assessment of the TSPO mitochondrial density in lymphomonocytes from civilian patients with non-combat-related PTSD, without current or lifetime Axis I mood comorbidity, versus controls; 2) the exploration of the correlations between TSPO density and the presence of comorbid manic/hypomanic lifetime spectrum symptoms. Assessments included the Structured Clinical Interview for DSM-IV (SCID), the Impact of Event Scale (IES), and the lifetime Mood Spectrum Self-Report (MOODS-SR). Blood samples were processed to assess TSPO binding parameters in lymphomonocyte mitochondrial membranes. PTSD patients showed a significant decrease in TSPO density, without changes in mitochondrial citrate synthase activity. Further, TSPO density correlated with the number of lifetime manic/hypomanic spectrum symptoms. For the first time, TSPO density was found to be decreased in non-war-related PTSD and such decreases correlated with comorbid manic/hypomanic spectrum symptoms, indicating a possible role of sub-threshold bipolar comorbidity in PTSD-related neurobiological dysregulation.
authors.affiliation: Department of Psychiatry, Neurobiology, Pharmacology and Biotechnologies, Pisa University, Pisa, Italy.
authors.forename: Liliana
authors.initials: L
authors.lastname: Dell'Osso
authors.forename: Eleonora
authors.initials: E
authors.lastname: Da Pozzo
authors.forename: Claudia
authors.initials: C
authors.lastname: Carmassi
authors.forename: Maria Letizia
authors.initials: ML
authors.lastname: Trincavelli
authors.forename: Antonio
authors.initials: A
authors.lastname: Ciapparelli
authors.forename: Claudia
authors.initials: C
authors.lastname: Martini
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000493:pharmacokinetics; D001714:Bipolar Disorder / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000493:pharmacokinetics; D008016:Life Change Events; D016014:Linear Models; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D051336:Mitochondrial Membranes / Q000187:drug effects; D011485:Protein Binding / Q000187:drug effects; D011569:Psychiatric Status Rating Scales; D018079:Receptors, GABA / Q000378:metabolism*; D013313:Stress Disorders, Post-Traumatic / Q000150:complications*; D014316:Tritium / Q000493:pharmacokinetics
chemical_list: D000970:Antineoplastic Agents; D007546:Isoquinolines; D018079:Receptors, GABA; C499229:TSPO protein, human; D014316:Tritium; C037850:PK 11195