Induction of apoptosis by tomato using space mutation breeding in human colon cancer SW480 and HT-29 cells.
BACKGROUND
As far as we know, there have been no reports concerning the functional characteristics of tomatoes using space mutation breeding. The aim of this study was to evaluate the anti-colon cancer effect of tomatoes M1 and M2 using space mutation breeding.


RESULTS
In the present study, obvious anti-cancer activity was shown with tomato juice of M1 and M2 and their parent CK treatment in colon cancer cell lines SW480 and HT-29 in cell growth inhibition. In addition, SW480 cells were more sensitive to M1 and M2 than HT-29 cells in cell apoptosis. Furthermore, M1 and M2 induced cell cycle arrest both in G0-G1 and G2/M phases.


CONCLUSIONS
These data suggest that consumption of tomato using space mutation breeding may provide benefits to inhibit growth of colon cancer cells. Therefore, tomato production using space mutation breeding may be a good candidate for development as a dietary supplement in drug therapy for colon cancer.
Shi
Jiahui
J
Department of Food Science and Nutrition, Zhejiang University, Hangzhou, China.
Yang
Bin
B
Feng
Pan
P
Li
Duo
D
Zhu
Jiajin
J
D000383:Agriculture / Q000379:methods; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use*; D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects*; D045744:Cell Line, Tumor; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005638:Fruit; D005821:Genetic Techniques; D019073:HT29 Cells; D006801:Humans; D018551:Solanum lycopersicum / Q000235:genetics*; D009154:Mutation; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology / Q000627:therapeutic use*
D000972:Antineoplastic Agents, Phytogenic; D028321:Plant Preparations