title: Singlet oxygen generation using iodinated squaraine and squaraine-rotaxane dyes.
abstract: The goal of this study was to assess the ability of squaraine-rotaxanes to generate singlet oxygen for potential application in photodynamic therapy (PDT). Specifically, we compare the aggregation and photophysical properties of an iodinated squaraine dye and an iodinated squaraine-rotaxane. Even under strongly aggregating conditions, the absorption spectra of both remain relatively sharp. An X-ray crystal structure of the iodinated squaraine dye shows that it adopts perpendicular, end-to-face orientations in the solid state. Singlet oxygen generation efficiency was measured by trapping with 1,3-diphenylisobenzofuran. The triplet state of the rotaxane was characterized using laser flash photolysis. The results of this study suggest that heavily halogenated squaraine-rotaxanes have potential as singlet oxygen photosensitizers for PDT.
authors.affiliation: Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA; ; Tel: 5746318632.
authors.forename: Easwaran
authors.initials: E
authors.lastname: Arunkumar
authors.forename: Pallikkara K
authors.initials: PK
authors.lastname: Sudeep
authors.forename: Prashant V
authors.initials: PV
authors.lastname: Kamat
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Noll
authors.forename: Bradley D
authors.initials: BD
authors.lastname: Smith