Myeloid sarcoma of the vagina: a report of 2 cases.
OBJECTIVE
To describe 2 cases of myeloid sarcoma of the vagina, in a patient without a history of acute myeloid leukemia (AML) and in another whose condition was previously diagnosed with AML.


METHODS
The clinical histories of 2 patients whose conditions were diagnosed with myeloid sarcoma of the vagina were obtained from their medical records.


RESULTS
Case 1: A 77-year-old woman with no systemic illnesses presented with a vaginal lump. Clinically, there was a 6-cm periurethral mass that was examined by biopsy. The histopathologic specimen was evaluated on routine and immunohistochemical stains, and myeloid sarcoma was diagnosed after extensive immunohistochemical analysis. The patient was treated with pelvic radiation. She developed extensive myeloid sarcoma of the skin and AML 4.5 months later; she died 2 weeks later, 5 months after the initial presentation. Case 2: A 36-year-old woman with a known history of AML who has had multiple leukemic and extramedullary recurrences presented with a pelvic mass. Physical findings revealed large masses in the vagina and rectovaginal septum, which were confirmed as myeloid sarcoma after biopsy and histologic examination. The patient was treated with pelvic/vaginal radiation. Five months later, she had another leukemic relapse and died within 1 day of palliative chemotherapy.


CONCLUSIONS
Myeloid sarcoma of the vagina is extremely rare. Most patients have a poor prognosis and either have a history of or will subsequently develop AML.
Skeete
Desiree H-A
DH
Department of Pathology, Faculty of Medical Sciences, Queen Elizabeth Hospital, St. Michael, Barbados.
Cesar-Rittenberg
Paula
P
Jong
Roland
R
Murray
Shawn K
SK
Colgan
Terence J
TJ
D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications; D023981:Sarcoma, Myeloid / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy; D012878:Skin Neoplasms / Q000556:secondary; D014621:Vagina / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy
D000951:Antigens, Neoplasm; C412325:SAGE1 protein, human