title: Emerging anticancer therapeutic targets and the cardiovascular system: is there cause for concern?
abstract: The race for a cure to cancer continues, fueled by unprecedented discoveries of fundamental biology underlying carcinogenesis and tumorigenesis. The expansion of the target list and tools to approach them is moving the oncology community extraordinarily rapidly to clinical trials, bringing new hope for cancer patients. This effort is also propelling biological discoveries in cardiovascular research, because many of the targets being explored in cancer play fundamental roles in the heart and vasculature. The combined efforts of cardiovascular and cancer biologists, along with clinical investigators in these fields, will be needed to understand how to safely exploit these efforts. Here, we discuss a few of the many research foci in oncology where we believe such collaboration will be particularly important.
authors.affiliation: Cardiovascular Medicine, Vanderbilt University Medical Center, PRB 359B Pierce Ave., Nashville, TN 37232, USA. xu-yang.peng@vanderbilt.edu
authors.forename: Xuyang
authors.initials: X
authors.lastname: Peng
authors.forename: Laura
authors.initials: L
authors.lastname: Pentassuglia
authors.forename: Douglas B
authors.initials: DB
authors.lastname: Sawyer
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D017209:Apoptosis / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000139:chemically induced* / Q000235:genetics / Q000378:metabolism; D002319:Cardiovascular System / Q000187:drug effects* / Q000378:metabolism; D004260:DNA Repair / Q000187:drug effects; D015507:Drugs, Investigational / Q000009:adverse effects*; D044127:Epigenesis, Genetic / Q000187:drug effects; D005109:Extracellular Matrix / Q000187:drug effects / Q000378:metabolism; D022001:Focal Adhesions / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D016023:Integrins / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism; D019899:Paracrine Communication / Q000187:drug effects; D046988:Proteasome Endopeptidase Complex / Q000187:drug effects / Q000378:metabolism; D018570:Risk Assessment; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D015507:Drugs, Investigational; D016023:Integrins; D018832:Molecular Chaperones; D046988:Proteasome Endopeptidase Complex