title: [The expression of oncogene c-myc and its role on human laryngeal cancer].
abstract: OBJECTIVE
  To detect the expression of oncogene c-myc and explore its role on human laryngeal cancer.
  
  
  METHODS
  The mRNA and of oncogene c-myc levels were detected in human laryngeal cancer tissues and laryngeal normal tissues by the means of real-time PCR and immunohistochemistry, respectively.
  
  
  RESULTS
  Compared with normal laryngeal tissues, the mRNA and protein levels of oncogene c-myc were both upregulated in laryngeal cancer tissues of all differentiation degree (P<0.05). Moreover, the level of c-myc was inverse correlated with the differentiation degree in human laryngeal cancer tissues.
  
  
  CONCLUSIONS
  The oncogene c-myc is overexpressed in human laryngeal cancer tissues, and c-myc may play an important role in carcinogenesis and progression of human laryngeal cancer tissues. It may provide a new target for gene therapy of human laryngeal cancer.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Long
authors.forename: Shuang
authors.initials: S
authors.lastname: Hu
authors.forename: Pingping
authors.initials: P
authors.lastname: Cao
authors.forename: Zheng
authors.initials: Z
authors.lastname: Liu
authors.forename: Hongtao
authors.initials: H
authors.lastname: Zhen
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Cui
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger