title: Intracranial transplant of olfactory ensheathing cells in children and adolescents with cerebral palsy: a randomized controlled clinical trial.
abstract: Successful repair of damage in cerebral palsy (CP) needs effective clinical interventions other than simply symptomatic treatments. To elucidate the feasibility of using olfactory ensheathing cells (OECs) to treat CP in children and adolescents, we conducted a randomized controlled clinical trial (RCT) on 33 patients. The patients were randomly assigned into two groups (treatment group, n = 18; control group, n = 15), and OECs derived from aborted fetal tissue were injected into the bilateral corona radiata in the frontal lobes (a key point for neural network restoration, KPNNR). The Gross Motor Function Measure (GMFM-66) and the Caregiver Questionnaire Scale were used to evaluate the patients' neurological function and overall health status. Among the 14 patients who completed the 6-month study, six received the cell transplantation and the other eight served as controls. In OEC treatment group, GMFM-66 scores were 26.67 +/- 25.33 compared with 19.00 +/- 20.00 for the control group. Concurrently, the Caregiver Questionnaire Scale score decreased to 77.83 +/- 15.99 in the treatment group in comparison to 138.66 +/- 64.06 of the control group. This trial, albeit small in sample size, indicates OEC KPNNR transplantation is effective for functional improvement in children and adolescents with CP, yet without obvious side effects. This small-scale study suggests that the procedure may be a plausible alternative method to treat this not yet curable disorder, and we urge further evaluation with a large-scale RCT.
authors.affiliation: Center for Neurorestoratology, Beijing, P R China.
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.forename: Hongyun
authors.initials: H
authors.lastname: Huang
authors.forename: Haitao
authors.initials: H
authors.lastname: Xi
authors.forename: Zihang
authors.initials: Z
authors.lastname: Xie
authors.forename: Ruiwen
authors.initials: R
authors.lastname: Liu
authors.forename: Zhao
authors.initials: Z
authors.lastname: Jiang
authors.forename: Feng
authors.initials: F
authors.lastname: Zhang
authors.forename: Yancheng
authors.initials: Y
authors.lastname: Liu
authors.forename: Di
authors.initials: D
authors.lastname: Chen
authors.forename: Qingmiao
authors.initials: Q
authors.lastname: Wang
authors.forename: Hongmei
authors.initials: H
authors.lastname: Wang
authors.forename: Yushui
authors.initials: Y
authors.lastname: Ren
authors.forename: Changman
authors.initials: C
authors.lastname: Zhou
mesh_terms: D000293:Adolescent; D017690:Cell Transplantation / Q000379:methods*; D002547:Cerebral Palsy / Q000503:physiopathology / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009457:Neuroglia / Q000166:cytology / Q000637:transplantation*; D009833:Olfactory Pathways / Q000166:cytology*; D020127:Recovery of Function; D011795:Surveys and Questionnaires; D016896:Treatment Outcome