The role of carrier size in the pharmacodynamics of antisense and siRNA oligonucleotides.
Effective therapeutic utilization of antisense and siRNA oligonucleotides represents a major challenge to drug delivery science. Although many strategies and technologies have been applied to oligonucleotide delivery, a key issue remains the role of molecular or carrier size. In this brief review, we address some of the size-related parameters that regulate the biodistribution of oligonucleotides. We also reprise several recent studies that have examined the inter-relationship of size and shape in influencing delivery.
Huang
Leaf
L
Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA.
Sullenger
Bruce
B
Juliano
Rudy
R
D000818:Animals; D052157:Aptamers, Nucleotide / Q000493:pharmacokinetics / Q000627:therapeutic use; D002199:Capillary Permeability; D004337:Drug Carriers; D042783:Endothelial Cells / Q000378:metabolism; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D008081:Liposomes / Q000493:pharmacokinetics; D053758:Nanoparticles; D016376:Oligonucleotides, Antisense / Q000493:pharmacokinetics* / Q000494:pharmacology*; D010316:Particle Size; D034741:RNA, Small Interfering / Q000493:pharmacokinetics* / Q000494:pharmacology*
D052157:Aptamers, Nucleotide; D004337:Drug Carriers; D008081:Liposomes; D016376:Oligonucleotides, Antisense; D034741:RNA, Small Interfering