title: Bone tissue, lyophilized and stored at room temperature for 15 days or more, is not capable of transmitting HIV, HCV or HBV.
abstract: Over the past 57 years, 17 recipients of frozen bone have been infected with: HIV (Centers for Disease Control and Prevention in Morb Mortal Wkly Rep MMWR 37(39):597-599, 1988; Li et al. in J Formos Med Assoc 100(5):350-351, 2001; Simonds et al. in NEJM 326(11):726-732, 1992; Schratt et al. in Unfallchirurg 99(9):679-684, 1996); HCV (Eggen and Nordbo in NEJM 326(6):411, 1992; Conrad et al. in J Bone Joint Surg Am 77:214-224, 1995; Trotter in J Bone Joint Surg Am 851(11):2215-2217, 2003; Tugwell et al. in Ann of Internal Med 143(9):648-654, 2005); or HBV (Shutkin in J Bone Joint Surg Am 36:160-162, 1954). However, bone, lyophilized and stored at room temperature, has never transmitted these viral diseases. A literature review was undertaken to determine whether there is any evidence that lyophilized bone is capable of transmitting HIV, HCV and HBV.
authors.affiliation: Nelson Levine de Luca & Horst, LLC, 518 E. Township Line Road, Blue Bell, PA 19422, USA. jsalvucci@nldhlaw.com
authors.forename: John T
authors.initials: JT
authors.lastname: Salvucci
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000821:virology*; D005612:Freeze Drying / Q000379:methods*; D006678:HIV / Q000472:pathogenicity; D015658:HIV Infections / Q000635:transmission*; D016174:Hepacivirus / Q000472:pathogenicity; D006515:Hepatitis B virus / Q000472:pathogenicity; D019694:Hepatitis B, Chronic / Q000635:transmission*; D019698:Hepatitis C, Chronic / Q000635:transmission*; D006801:Humans