title: Soybean lipoxygenase inhibitory and DPPH radical-scavenging activities of aspernolide A and butyrolactones I and II.
abstract: Aspernolide A and butyrolactones I and II showed inhibitory activities against soybean lipoxygenase. All of them also had DPPH (2,2-diphenyl-1-picrylhydrazyl) radical-scavenging activity. An analysis of the mechanism for radical scavenging allowed us to deduce that aspernolide A was converted to a quinone methide by a reaction with two molecules of the DPPH radical.
authors.affiliation: Laboratory of Applied Microbiology, School of Food and Nutritional Sciences, University of Shizuoka, Japan. sugiyasu@u-shizuoka-ken.ac.jp
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Sugiyama
authors.forename: Kayo
authors.initials: K
authors.lastname: Yoshida
authors.forename: Naoki
authors.initials: N
authors.lastname: Abe
authors.forename: Akira
authors.initials: A
authors.lastname: Hirota
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives; D001713:Biphenyl Compounds; D004032:Diet; D007287:Inorganic Chemicals; D008084:Lipoxygenase / Q000378:metabolism*; D009930:Organic Chemicals; D010851:Picrates; D013025:Glycine max / Q000201:enzymology
chemical_list: D015107:4-Butyrolactone; D001713:Biphenyl Compounds; D007287:Inorganic Chemicals; D008084:Lipoxygenase; D009930:Organic Chemicals; D010851:Picrates; C010574:biphenyl; C082868:butyrolactone I; C004931:1,1-diphenyl-2-picrylhydrazyl