title: Assessment of long term status of sputum positive pulmonary TB patients successfully treated with short course chemotherapy.
abstract: BACKGROUND
  Long term status of pulmonary tuberculosis (PTB) patients treated with short course chemotherapy (SCC) regimens remains unknown.
  
  
  OBJECTIVE
  To assess the clinical, bacteriological, radiological status and health related quality of life (HRQoL) of PTB patients 14-18 years after successful treatment with SCC.
  
  
  METHODS
  In a cross-sectional study, cured PTB patients treated during 1986-1990 at the Tuberculosis Research Centre (TRC) were investigated for their current health status including pulmonary function tests (PFT). The St Georges respiratory questionnaire (SGRQ) was used to assess the HRQoL.
  
  
  RESULTS
  The mean period after treatment completion for the 363 eligible participants was 16.5 yrs (range 14-18 yrs., 84% coverage); 25 (7%) had been re-treated and 52 (14%) died. Among the investigated, 58 (29%) had persistent respiratory symptoms; 170 (86%) had radiological sequelae but none had active disease. Abnormal PFT was observed in 96 (65%) with predominantly restrictive type of disease in 66 (45%). The SGRQ scores for activity and impact were high implying impairment in HRQoL.
  
  
  CONCLUSIONS
  Assessment of long term status of cured PTB patients showed an impairment of lung functions and HRQoL highlighting the need to address these issues in the management of TB that may provide added value to patient care.
authors.affiliation: Tuberculosis Research Centre, Chennai.
authors.forename: V V
authors.initials: VV
authors.lastname: Banu Rekha
authors.forename: Rajeswari
authors.initials: R
authors.lastname: Ramachandran
authors.forename: K V
authors.initials: KV
authors.lastname: Kuppu Rao
authors.forename: Fathima
authors.initials: F
authors.lastname: Rahman
authors.forename: A R
authors.initials: AR
authors.lastname: Adhilakshmi
authors.forename: D
authors.initials: D
authors.lastname: Kalaiselvi
authors.forename: P
authors.initials: P
authors.lastname: Murugesan
authors.forename: V
authors.initials: V
authors.lastname: Sundaram
authors.forename: P R
authors.initials: PR
authors.lastname: Narayanan
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012129:Respiratory Function Tests; D012907:Smoking / Q000453:epidemiology; D013183:Sputum / Q000382:microbiology*; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology
chemical_list: D000995:Antitubercular Agents