The role of Gβ5 in vision.
Recent advances in our understanding of R7RGS proteins have benefited from studies involving the fifth member of the Gβ family (Gβ5) that is found throughout the visual system. Unlike conventional Gβsthat form dimers with Gγ, Gβ5 partners with R7RGS proteins, which contain the G-protein gamma-like (GGL) domain, to act as a GTPase accelerating protein (GAP) complex on certain Gα subunits. Recent studies in the retina underscore the necessity of Gβ5 for normal recovery in photoreceptors and light responses in ON-bipolar cells. Gβ5 may also be important for the generation and propagation of spontaneous retinal waves in retina and proper synapse formation in lateral geniculate nucleus (LGN). Here, we review these findings and discuss future investigative directions concerning Gβ5's function in vision.
Morhardt
Duncan R
DR
Department of Biochemistry and Molecular Biology, Virginia Commonwealth University, Richmond, Virginia 23298, USA.
Guido
William
W
Chen
Ching-Kang Jason
CK
D000818:Animals; D044387:GTP-Binding Protein beta Subunits / Q000378:metabolism*; D006801:Humans; D055537:Light Signal Transduction; D020710:RGS Proteins / Q000378:metabolism; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism; D051245:Retinal Bipolar Cells / Q000378:metabolism; D014785:Vision, Ocular / Q000502:physiology*
D044387:GTP-Binding Protein beta Subunits; D020710:RGS Proteins; D018094:Receptors, Metabotropic Glutamate; C113897:metabotropic glutamate receptor 6; C116925:regulator of g-protein signaling 9