title: Smart nanofibers with a photoresponsive surface for controlled release.
abstract: A novel photocontrolled "ON-OFF" release system for the alpha-cyclodextrin-5-fluorouracial (alpha-CD-5FU) prodrug, based on host-guest interaction on the photoresponsive and cross-linked nanofiber surface, was demonstrated. The nanofibers with a stimuli-responsive surface were electrospun from the block copolymer prepared via controlled radical polymerization, followed by surface modification via "Click Chemistry", and loading of the prodrug via host-guest interaction.
authors.forename: Guo-Dong
authors.initials: GD
authors.lastname: Fu
authors.forename: Li-Qun
authors.initials: LQ
authors.lastname: Xu
authors.forename: Fang
authors.initials: F
authors.lastname: Yao
authors.forename: Guo-Liang
authors.initials: GL
authors.lastname: Li
authors.forename: En-Tang
authors.initials: ET
authors.lastname: Kang
mesh_terms: D003432:Cross-Linking Reagents / Q000494:pharmacology; D003692:Delayed-Action Preparations; D008027:Light; D057139:Nanofibers / Q000737:chemistry* / Q000648:ultrastructure; D056951:Photoelectron Spectroscopy; D013499:Surface Properties / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors; D047391:alpha-Cyclodextrins / Q000494:pharmacology*
chemical_list: D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D047391:alpha-Cyclodextrins; C032613:alpha-cyclodextrin