[Comparative study of magnesium salts bioavailability in rats fed a magnesium-deficient diet].
The purpose of this study was to compare efficiency of compensation of alimentary Mg deficiency after administration of 12 organic and 8 inorganic magnesium salts and to evaluate the ability of vitamin B6 to accelerate their effect. Two hundred eighty rats were placed on a Mg-deficient diet (Mg content (15 mg/kg) and demineralized water for 7 weeks. Twelve control rats were fed a basal diet (Mg content 500 mg/kg). Starting from day 49 of the Mg-deficient diet, the rats were given magnesium salts (50 mg magnesium and 5 mg pyridoxine per kg): Mg chloride, Mg sulphate, Mg oxide, M nitrate, Mg thiosulphate, Mg hydrophosphate, Mg carbonate, Mg trisilicate, Mg (L-, D- and DL-) aspartate, Mg (L- and DL-) pyroglutamate, Mg succinate, Mg glycinate, Mg orotate, Mg taurate, Mg lactate or their combination with vitamin B6 (5 mg/kg b.w.). Erythrocyte and plasma Mg levels were measured by spectrophotometry following the colour reaction between Mg and titanium yellow. Mg L-aspartate compensated for magnesium deficit more effectively and faster than all other salts. Mg chloride showed the highest efficiency among inorganic magnesium salts. Both Mg chloride and Mg L-aspartate in combination with vitamin B6 caused statistically significant compensation of magnesium deficit.
Spasov
A A
AA
Petrov
V I
VI
Iezhitsa
I N
IN
Kravchenko
M S
MS
Kharitonova
M V
MV
Ozerov
A A
AA
D000284:Administration, Oral; D000818:Animals; D001224:Aspartic Acid / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D008274:Magnesium / Q000097:blood*; D015636:Magnesium Chloride / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008275:Magnesium Deficiency / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D008297:Male; D009751:Nutritional Requirements; D051381:Rats; D016896:Treatment Outcome; D025101:Vitamin B 6 / Q000008:administration & dosage / Q000493:pharmacokinetics
D015636:Magnesium Chloride; D001224:Aspartic Acid; D025101:Vitamin B 6; D008274:Magnesium