title: Experimental investigation of the immunoregulatory and anti-inflammatory effects of the traditional Chinese medicine "Li-Yan Zhi-Ke Granule" for relieving chronic pharyngitis in rats.
abstract: Chronic pharyngitis, a chronic inflammation of the pharyngeal mucous membrane and submucous lymphoid tissues, is often caused by unsatisfactory treatment of acute pharyngitis or repeated occurrences of upper respiratory tract infection and is related to a high-dust environment. Traditional herbal pharmacotherapy is well known for combining plant species to create complex phytochemical mixtures in the attempt to ameliorate pathophysiological processes. The aim of current study is to investigate the effect of immunoregulation and anti-inflammation with the traditional Chinese medicine (TCM) "Li-Yan Zhi-Ke Granule" in rats. Determination of serum hemolysin and the carbon particle clearance test were performed. The results demonstrate that administration of the TCM "Li-Yan Zhi-Ke Granule" may improve the effect of phagocytosis by mononuclear macrophages and immune function in rats, and may also increase the immunoregulatory and anti-inflammatory responses of rats with chronic pharyngitis. This traditional drug could relieve the symptoms of sore throat and cough in rats with chronic pharyngitis.
authors.affiliation: Chengdu Medical College, and West China Hospital, Chengdu, 610083, Sichuan Province, China.
authors.forename: Yiyi
authors.initials: Y
authors.lastname: Sun
authors.forename: Zhihe
authors.initials: Z
authors.lastname: Zang
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Xu
authors.forename: Zhonglin
authors.initials: Z
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Zhong
authors.forename: Wang
authors.initials: W
authors.lastname: Zan
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Lin
authors.initials: L
authors.lastname: Sun
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D000917:Antibody Formation / Q000187:drug effects; D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use*; D006460:Hemolysin Proteins / Q000097:blood / Q000276:immunology; D056747:Immunomodulation / Q000187:drug effects*; D008516:Medicine, Chinese Traditional; D051379:Mice; D012157:Mononuclear Phagocyte System / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D010612:Pharyngitis / Q000097:blood / Q000188:drug therapy*; D008517:Phytotherapy; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D006460:Hemolysin Proteins; C556667:li-yan zhi-ke