[Diagnostic significance of B-type natriuretic peptide combined with noninvasive cardiac output monitoring in patients with dyspnea.].
OBJECTIVE
To explore the clinical significance of carrying out fast blood B-type natriuretic peptide (BNP) detection together with noninvasive hemodynamic monitoring for pathogenic diagnosis in patients with dyspnea and to assess further the application value of noninvasive cardiac output monitoring in emergency room.


METHODS
354 patients were diagnosed as dyspnea in the Emergency Department of Chaoyang Hospital, being Affiliated to Capital Medical University during a period from May 2007 to January 2008 by using USCOM noninvasive ultrasonic cardiac output monitor to measure cardiac output (CO). If CO was less than 4 L/min, cardiac dyspnea will be diagnosed. Meanwhile, certain amount of venous blood was kept for rapid measuring of BNP concentration. If BNP concentration was higher than 100 pg/ml, cardiac dyspnea would be diagnosed. After diagnosis was made clearly, all the 354 patients were divided in two groups according to Framingham standards whether they had cardiac dyspnea or not and then comparison was carried out between the patients with the diagnosis of cardiac dyspnea with CO and BNP. The relationship between CO and BNP was studied as well.


RESULTS
In a group of 127 patients with cardiac dyspnea, there was no difference in terms of the number of patients showing positive results with CO or BNP as judging criteria (122 vs 119, P = 0.393) and CO and BNP had negative correlation; while the results were opposite in a group of 227 patients with non-cardiac dyspnea (102 vs 11, showing negative CO or BNP P = 0.000) and there was no correlation between BNP and CO.


CONCLUSIONS
For patients with dyspnea in the emergency room, the value of BNP concentration of blood plasma to determine cardiac dyspnea is somewhat limited. Appling non-invasive ultrasonic cardiac output monitor in the emergency room to detect CO for identifying the cause of dyspnea is clinically valuable.
Wu
Cai-Jun
CJ
Emergency Department of Chaoyang Hospital Being Affiliated to Capital Medical University, Beijing 100020, China.
Li
Chun-Sheng
CS
Li
Hong
H
D002302:Cardiac Output; D004417:Dyspnea; D006333:Heart Failure / Q000097:blood; D006801:Humans; D008991:Monitoring, Physiologic; D020097:Natriuretic Peptide, Brain / Q000097:blood
D020097:Natriuretic Peptide, Brain