title: [A comparative study of voxel-based morphometry in patients with paranoid schizophrenia and bipolar mania].
abstract: OBJECTIVE
  To assess volumetric abnormalities of grey matter in the brains of patients with paranoid schizophrenia and bipolar disorder (mania).
  
  
  METHODS
  3D T1 weighted images were acquired by magnetic resonance imaging from 20 patients with paranoid schizophrenia, 20 patients with bipolar disorder (mania) and 20 control subjects. Regional deviation in gray matter volume was assessed using optimized volumetric voxel-based morphometry. ANOVA was performed to test the difference of the gray matter volume (GMV).
  
  
  RESULTS
  Compared with controls, the patients with paranoid schizophrenia showed decreased gray matter volume in left superior temporal gyrus, right middle temporal gyrus and inferior temporal gyrus, and increased gray matter volume in bilateral inferior frontal gyrus and bilateral claustrum. Whereas, the patients with bipolar disorder (mania) showed decreased gray matter volume in right superior temporal gyrus, middle temporal gyrus, inferior temporal gyrus and bilateral caudate, and increased gray matter volume in bilateral precuneus, left postcentral gyrus, right superior frontal gyrus and left cingulated gyrus. The patients with paranoid schizophrenic patients had greater gray matter volume in left inferior frontal gyrus, left superior temporal gyrus and right caudate than the patients with bipolar disorder.
  
  
  CONCLUSIONS
  Patients with schizophrenic and bipolar disorder have different changes in brain structure. However, they also share the same reduction of GDV in right temporal gyrus.
authors.affiliation: Psychiatric Laboratory & Department of Psychiatry, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Li-Qian
authors.initials: LQ
authors.lastname: Cui
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Jiang
authors.forename: Chao-Hua
authors.initials: CH
authors.lastname: Huang
authors.forename: Zhuang-Fei
authors.initials: ZF
authors.lastname: Chen
authors.forename: Ming-Li
authors.initials: ML
authors.lastname: Li
authors.forename: Qi-Yong
authors.initials: QY
authors.lastname: Gong
authors.forename: Tao
authors.initials: T
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D012563:Schizophrenia, Paranoid / Q000473:pathology*; D055815:Young Adult