Phosphatase 2A puts the brakes on mTORC1 nutrient signaling.
Nutrients such as amino acids (aa) and glucose mediate mammalian target of rapamycin complex 1 (mTORC1) signaling to control cell growth and metabolism. Recent studies (Yan et al., 2010) identify a contributor, PP2A phosphatase subunit PR61varepsilon, in regulating the aa-sensitive input to mTORC1.
Selvaraj
Anand
A
Department of Cancer and Cell Biology, Metabolic Diseases Institute, University of Cincinnati, 2180 East Galbraith Road, Cincinnati, OH 45237, USA.
Thomas
George
G
D005947:Glucose / Q000378:metabolism; D006801:Humans; D000076222:Mechanistic Target of Rapamycin Complex 1; D008954:Models, Biological; D046912:Multiprotein Complexes; D009747:Nutritional Physiological Phenomena / Q000502:physiology*; D009765:Obesity / Q000150:complications / Q000209:etiology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D010766:Phosphorylation; D054648:Protein Phosphatase 2 / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D011506:Proteins; D015398:Signal Transduction / Q000502:physiology*; D058570:TOR Serine-Threonine Kinases; D014157:Transcription Factors / Q000378:metabolism*
D005947:Glucose; D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes; D019869:Phosphatidylinositol 3-Kinases; D054648:Protein Phosphatase 2; D017346:Protein Serine-Threonine Kinases; D011506:Proteins; D058570:TOR Serine-Threonine Kinases; D014157:Transcription Factors; C543044:MAP4K3 protein, human