[The actoprotective action of thiazoloindole antihypoxic agents].
A series of 12 compounds belonging to thiazoloindole derivatives possessing the antihypoxic activity were studied in order to reveal their actoprotective properties under usual and complicated (threatbahn running, exhaustive swimming) conditions in rats and mice. Five compounds were shown to protect animals from exhaustive loads in 1 h and 24 h after administration; four compounds produced the same effect under acute hypercapnic hypoxia conditions. In contrast, under the conditions of acute hemic hypoxia, all compound possessing high antihypoxic properties did not affect the physical endurance in rats and mice.
Gavreev
A I
AI
Marysheva
V V
VV
Shabanov
P D
PD
D000818:Animals; D006935:Hypercapnia / Q000517:prevention & control*; D000860:Hypoxia / Q000517:prevention & control*; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D010807:Physical Endurance; D051381:Rats; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D007211:Indoles; D013844:Thiazoles