title: Molecular Medicine - CHI's 17th International Tri-Conference: Mastering Medicinal Chemistry - CHI's Seventh Annual Conference.
abstract: CHI's 17th International Tri-Conference on Molecular Medicine, held in San Francisco, included topics covering the drug discovery process, with an emphasis on lead optimization. This conference report highlights selected presentations on the development of several launched and investigational drugs, including Plerixafor, Trox-1 (CombinatoRX Inc), lorcaserin (Arena Pharmaceuticals Inc), vorapaxar (Merck & Co Inc) and ulimorelin (Tranzyme Pharma Inc).
authors.affiliation: Arena Pharmaceuticals, San Diego, CA 92127, USA. gsemple@arenapharm.com
authors.forename: Graeme
authors.initials: G
authors.lastname: Semple
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001552:Benzazepines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001596:Benzylamines; D002121:Calcium Channel Blockers / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical; D003324:Coronary Artery Disease / Q000188:drug therapy; D000080027:Cyclams; D055808:Drug Discovery / Q000379:methods / Q000639:trends*; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D045823:Ileus / Q000188:drug therapy; D007783:Lactones / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D009765:Obesity / Q000188:drug therapy; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D019718:Receptors, CXCR4 / Q000037:antagonists & inhibitors; D054440:Receptors, Ghrelin / Q000819:agonists; D058826:Serotonin 5-HT2 Receptor Agonists; D017366:Serotonin Receptor Agonists / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors
chemical_list: D019380:Anti-HIV Agents; D001552:Benzazepines; D001596:Benzylamines; C527276:CXCR4 protein, human; D002121:Calcium Channel Blockers; D000080027:Cyclams; D006571:Heterocyclic Compounds; D007783:Lactones; D047028:Macrocyclic Compounds; D011725:Pyridines; D019718:Receptors, CXCR4; D054440:Receptors, Ghrelin; D058826:Serotonin 5-HT2 Receptor Agonists; D017366:Serotonin Receptor Agonists; C506658:lorcaserin; C528884:ulimorelin; C088327:plerixafor; C530299:vorapaxar; D010975:Platelet Aggregation Inhibitors