title: Elevated blood markers 1 year before manifestation of malignant glioma.
abstract: We detected distinct plasma concentration profiles of S100B, neuropeptide Y, and secretagogin in 3 of 191 patients enrolled in a previous study investigating brain-tissue-related markers in the blood of patients with atrial fibrillation. Intriguingly, 2 of these 3 patients, both of whom were without neurological symptoms at the time of blood sampling, were diagnosed with malignant glioma (MG) approximately 1 year later. To our knowledge, this is the first report indicating that distinct blood biomarker profiles may be detected long before clinical manifestation of MG.
authors.affiliation: Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Gartner
authors.forename: Aysegül
authors.initials: A
authors.lastname: Ilhan
authors.forename: Dashurie
authors.initials: D
authors.lastname: Neziri
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Base
authors.forename: Michael
authors.initials: M
authors.lastname: Weissel
authors.forename: Adelheid
authors.initials: A
authors.lastname: Wöhrer
authors.forename: Harald
authors.initials: H
authors.lastname: Heinzl
authors.forename: Thomas
authors.initials: T
authors.lastname: Waldhör
authors.forename: Ludwig
authors.initials: L
authors.lastname: Wagner
authors.forename: Matthias
authors.initials: M
authors.lastname: Preusser
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D001932:Brain Neoplasms / Q000097:blood*; D002135:Calcium-Binding Proteins / Q000097:blood*; D005260:Female; D005910:Glioma / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000097:blood*; D009478:Neuropeptide Y / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*; D064046:Secretagogins; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D009414:Nerve Growth Factors; D009478:Neuropeptide Y; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; C576556:SCGN protein, human; D064046:Secretagogins