title: Lesion load of the corticospinal tract predicts motor impairment in chronic stroke.
abstract: OBJECTIVE
  Previous studies have shown motor impairment after a stroke relates to lesion size and location, but unexplained variability in recovery still exists. In this study, we used lesion-mapping techniques in combination with diffusion tensor imaging to quantitatively test the hypothesis that motor recovery in patients with chronic stroke is inversely related to the proportion of the corticospinal tract (CST) affected by the lesion.
  
  
  METHODS
  We studied 50 patients with chronic stroke, all of whom presented with moderate to severe motor impairments in the acute stage, using high-resolution anatomic MRI. We evaluated the degree of motor impairment with the Upper Extremity module of the Fugl-Meyer Assessment. To analyze the relationship between CST damage and impairment scores, we calculated a CST-lesion load for each patient by overlaying the patient's lesion map with a probabilistic tract derived from diffusion tensor images of age-matched healthy subjects.
  
  
  RESULTS
  CST-lesion load was a significant predictor of motor deficit. Infarct size, despite correlating with motor scores, did not significantly predict impairment.
  
  
  CONCLUSIONS
  Our results show the degree of functional motor deficit after a stroke is highly dependent on the overlap of the lesion with the CST and not lesion size per se. In the future, automated calculation of CST-lesion load may allow more precise prediction of motor impairment after stroke.
authors.affiliation: Department of Neurology, Beth Israel Deaconess Medical Center/Harvard Medical School, 330 Brookline Avenue, Boston, MA 02215, USA.
authors.forename: Lin L
authors.initials: LL
authors.lastname: Zhu
authors.forename: Robert
authors.initials: R
authors.lastname: Lindenberg
authors.forename: Michael P
authors.initials: MP
authors.lastname: Alexander
authors.forename: Gottfried
authors.initials: G
authors.lastname: Schlaug
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology; D002908:Chronic Disease; D056324:Diffusion Tensor Imaging / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019957:Motor Skills Disorders / Q000209:etiology / Q000473:pathology*; D011237:Predictive Value of Tests; D011712:Pyramidal Tracts / Q000473:pathology*; D020521:Stroke / Q000150:complications / Q000473:pathology*