Functional correlates of instrumental activities of daily living in mild Alzheimer's disease.
Instrumental activities of daily living (IADL) includes the integration of task-initiation, -planning, and -performance. Little is known on the cerebral perfusion correlates of these subcomponents of IADL in Alzheimer's disease (AD). In 121 AD patients, cerebral perfusion, using single-photon emission computed tomography, in 13 bilateral regions of interest (ROI) and the perfusion correlates of IADL subcomponents, rated on the Disability Assessment in Dementia scale, were explored. Significant correlations were observed between IADL initiation and multiple bilateral prefrontal-striatal-anterior cingulate ROI (p < 0.01), IADL planning and right occipital ROI (p < 0.05), and IADL performance and right parietal ROI (p < 0.05). Multiple regression, accounting for age, cognitive impairment, and depression severity, revealed significant relationship between right basal ganglia perfusion and IADL-initiation (R = 0.6, R(2) = 0.39, F(4,117) = 17.8, SE = 1.56; p < 0.001) and right occipital perfusion and IADL-planning (R = 0.6, R(2) = 0.34, F(4,117) = 19.5, SE = 1.47; p < 0.001). In AD, perfusion correlates of these subcomponents may be linked to the heterogenous cognitive processes involved in IADL.
Nadkarni
Neelesh K
NK
L C Campbell Cognitive Neurology Research Unit, Neuroscience Research Program, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. neelesh.nadkarni@utoronto.ca
Levy-Cooperman
Naama
N
Black
Sandra E
SE
D000203:Activities of Daily Living; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000503:physiopathology* / Q000523:psychology; D001479:Basal Ganglia / Q000098:blood supply / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D003071:Cognition; D056344:Executive Function; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000098:blood supply / Q000000981:diagnostic imaging*; D010296:Parietal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging*; D017397:Prefrontal Cortex / Q000098:blood supply / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D012044:Regression Analysis; D012720:Severity of Illness Index