[New ophthalmic insert].
Controlled release of drugs on ocular level is an important care for modern pharmacology. New studies targets are medical ophthalmic products with prolonged action (controlled release, target release). The hydrogel is an important segment in these studies. The purpose of this study is to assess a monolithic thermosensible hydrogel for releasing a certain medical product.


METHODS
We used several materials for making thermosensible ophthalmic inserts that were processed (hydrogel synthesis, establish the inflation degree, hydrogel drug inclusion, establish the kinetics of in vitro drug releasing, in vivo studies).


RESULTS
The study show that MA-G and PNIPAm basis hydrogel is a smart one that have the ability to collapse on a temperature closed to the physiological one, the result is the drug release in a desired doses. The hydrogel is perfectly tolerated, an experimental study prove that.


CONCLUSIONS
Controlled release of active drug that are highly adequate to have a clinical response is based on small doses, without adverse effects. Is a target release.
Hamcerencu
Mihaela
M
"Gh. Asachi" Technical University, Faculty of Chemical Engineering, Department of Natural and Synthetic Polymers, Bd. D. Mangeron, nr. 71 A, 700050 Iasi, Romania.
Popa
Marcel
M
Costin
Danut
D
Bucatariu
Paul
P
Desebrieres
Jacques
J
Riess
Gerard
G
D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*; D004343:Drug Implants; D005128:Eye Diseases / Q000188:drug therapy*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000737:chemistry*; D016896:Treatment Outcome
D004337:Drug Carriers; D004343:Drug Implants; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate