title: Oncological patterns of care and outcome for 952 patients with newly diagnosed glioblastoma in 2004.
abstract: This report, an audit requested by the French government, describes oncological patterns of care, prognostic factors, and survival for patients with newly diagnosed and histologically confirmed glioblastoma multiforme (GBM) in France. The French Brain Tumor DataBase, which is a national multidisciplinary (neurosurgeons, neuropathologists, radiotherapists, neurooncologists, epidemiologists, and biostatisticians) network, prospectively collected initial data for the cases of GBM in 2004, and a specific data card was used to retrospectively collect data on the management and follow-up care of these patients between January 1, 2004, and December 1, 2006. We recorded 952 cases of GBM (male/female ratio 1.6, median age 63.9 years, mean preoperative Karnofsky performance status [KPS] 79). Surgery consisted of resection (RS; n = 541) and biopsy (n = 411); 180 patients did not have subsequent oncological treatment. After surgery, first-line treatment (n = 772) consisted of radiotherapy (RT) and temozolomide (TMZ) concomitant +/- adjuvant in 314 patients, RT alone in 236 patients, chemotherapy (CT) alone in 157 patients, and other treatment modalities in 65 patients. Median overall survival was 286 days (95% CI, 266-314) and was significantly affected by age, KPS, and tumor location. Median survival (days, 95% CI) associated with these main strategies, when analyzed by a surgical group, were as follows: RS + RT-TMZ((n=224)): 476 (441-506), biopsy + RT-TMZ((n=90)): 329 (301-413), RS + RT((n=147)): 363 (331-431), biopsy + RT((n=89)): 178 (153-237), RS + CT((n=61)): 245 (190-361), biopsy + CT((n=96)): 244 (198-280), and biopsy only((n=118)): 55 (46-71). This study illustrates the usefulness of a national brain tumor database. To our knowledge, this work is the largest report of recent GBM management in Europe.
authors.affiliation: Department of Neurosurgery, Hospital Gui de Chauliac, CHU Montpellier, 80 avenue A. Fliche, 34295 Montpellier cedex 5, France. l-bauchet@chu-montpellier.fr
authors.forename: Luc
authors.initials: L
authors.lastname: Bauchet
authors.forename: Hélène
authors.initials: H
authors.lastname: Mathieu-Daudé
authors.forename: Pascale
authors.initials: P
authors.lastname: Fabbro-Peray
authors.forename: Valérie
authors.initials: V
authors.lastname: Rigau
authors.forename: Michel
authors.initials: M
authors.lastname: Fabbro
authors.forename: Olivier
authors.initials: O
authors.lastname: Chinot
authors.forename: Loreleï
authors.initials: L
authors.lastname: Pallusseau
authors.forename: Charlotte
authors.initials: C
authors.lastname: Carnin
authors.forename: Karl
authors.initials: K
authors.lastname: Lainé
authors.forename: Aline
authors.initials: A
authors.lastname: Schlama
authors.forename: Agnes
authors.initials: A
authors.lastname: Thiebaut
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Patru
authors.forename: Fabienne
authors.initials: F
authors.lastname: Bauchet
authors.forename: Martine
authors.initials: M
authors.lastname: Lionnet
authors.forename: Michel
authors.initials: M
authors.lastname: Wager
authors.forename: Thierry
authors.initials: T
authors.lastname: Faillot
authors.forename: Luc
authors.initials: L
authors.lastname: Taillandier
authors.forename: Dominique
authors.initials: D
authors.lastname: Figarella-Branger
authors.forename: Laurent
authors.initials: L
authors.lastname: Capelle
authors.forename: Hugues
authors.initials: H
authors.lastname: Loiseau
authors.forename: Didier
authors.initials: D
authors.lastname: Frappaz
authors.forename: Chantal
authors.initials: C
authors.lastname: Campello
authors.forename: Christine
authors.initials: C
authors.lastname: Kerr
authors.forename: Hugues
authors.initials: H
authors.lastname: Duffau
authors.forename: Monique
authors.initials: M
authors.lastname: Reme-Saumon
authors.forename: Brigitte
authors.initials: B
authors.lastname: Trétarre
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Daures
authors.forename: Dominique
authors.initials: D
authors.lastname: Henin
authors.forename: François
authors.initials: F
authors.lastname: Labrousse
authors.forename: Philippe
authors.initials: P
authors.lastname: Menei
authors.forename: Jérome
authors.initials: J
authors.lastname: Honnorat
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D005602:France / Q000453:epidemiology; D005909:Glioblastoma / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D058028:Research Report / Q000592:standards*; D012189:Retrospective Studies; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult