title: Application of poly(amidoamine) dendrimers for use in bionanomotor systems.
abstract: The study and utilization of bionanomotors represents a rapid and progressing field of nanobiotechnology. Here, we demonstrate that poly(amidoamine) (PAMAM) dendrimers are capable of supporting heavy meromyosin dependent actin motility of similar quality to that observed using nitrocellulose, and that microcontact printing of PAMAM dendrimers can be exploited to produce tracks of active myosin motors leading to the restricted motion of actin filaments across a patterned surface. These data suggest that the use of dendrimer surfaces will increase the applicability of using protein biomolecular motors for nanotechnological applications.
authors.affiliation: Cell Differentiation and Development Center, Joan C. Edwards School of Medicine, Huntington, West Virginia, USA.
authors.forename: Madhukar B
authors.initials: MB
authors.lastname: Kolli
authors.forename: B Scott
authors.initials: BS
authors.lastname: Day
authors.forename: Hideyo
authors.initials: H
authors.lastname: Takatsuki
authors.forename: Siva K
authors.initials: SK
authors.lastname: Nalabotu
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Rice
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kohama
authors.forename: Murali K
authors.initials: MK
authors.lastname: Gadde
authors.forename: Sunil K
authors.initials: SK
authors.lastname: Kakarla
authors.forename: Anjaiah
authors.initials: A
authors.lastname: Katta
authors.forename: Eric R
authors.initials: ER
authors.lastname: Blough
mesh_terms: D000818:Animals; D002417:Cattle; D003101:Collodion / Q000737:chemistry; D050091:Dendrimers / Q000737:chemistry*; D004560:Electricity; D009068:Movement; D009218:Myosins / Q000378:metabolism; D036103:Nanotechnology / Q000379:methods*; D013499:Surface Properties; D017971:Tin Compounds / Q000737:chemistry
chemical_list: D050091:Dendrimers; C104700:PAMAM Starburst; D017971:Tin Compounds; C109984:indium tin oxide; D003101:Collodion; D009218:Myosins