title: Longitudinal Doppler strain measurement for assessment of damaged and/or hibernating myocardium by dobutamine stress echocardiography in patients with old myocardial infarction.
abstract: BACKGROUND
  The ratio of systolic lengthening to combined late and postsystolic shortening (L/TS ratio) on longitudinal Doppler strain imaging (Doppler SI) may be an index of myocardial viability. We hypothesized that measuring the postsystolic index (PSI) and the L/TS ratio during dobutamine stress echocardiography (DSE) could quantitatively identify viable myocardium with the potential for regional functional recovery.
  
  
  METHODS
  Thirty-eight patients with old myocardial infarction (OMI) underwent DSE with Doppler SI and coronary angiography (Group 1). To clarify the value of measuring the PSI and L/TS ratio by DSE with Doppler SI in patients with OMI, these Doppler parameters and visual analysis of wall motion abnormality (WMA) were compared on a segmental basis. To investigate the prediction of regional functional recovery, 10 patients with OMI (Group 2) and stenosis of the infarct-related coronary artery underwent DSE with Doppler SI before and after percutaneous coronary intervention.
  
  
  RESULTS
  In Group 1, 143 out of 556 segments showed a biphasic WMA pattern during DSE. There were no segments with evidence of necrosis. The PSI at peak stress was > or =0.25 in 114 out of 143 segments and the L/TS ratio at peak stress was >0 in 82 out of 114 segments. Regarding functional recovery, 42 of the 73 segments with WMA at rest showed improvement after reperfusion. The wall motion score (WMS) showed 86% sensitivity and 71% specificity for predicting regional recovery, while PSI and L/TS ratio showed 61% vs. 84% sensitivity and 60% vs. 79% specificity, respectively. The AUC for the ROC curve of the L/TS ratio as a predictor of regional recovery was significantly larger compared with that of WMS (0.894 vs. 0.783, p<0.05).
  
  
  CONCLUSIONS
  The peak stress L/TS ratio could be a specific and quantitative marker for identifying myocardial viability that has the potential for regional functional recovery.
authors.affiliation: Department of Internal Medicine, Division of Cardiology, Nippon Medical School, 1-1-5, Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. fujihiro@eurus.dti.ne.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Fujimoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Honma
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Ohno
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Mizuno
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kumita
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D004280:Dobutamine; D025401:Echocardiography, Stress; D005260:Female; D006321:Heart / Q000502:physiology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D009203:Myocardial Infarction / Q000000981:diagnostic imaging*; D017682:Myocardial Stunning / Q000000981:diagnostic imaging*; D015588:Observer Variation; D012680:Sensitivity and Specificity; D013599:Systole / Q000502:physiology; D014022:Tissue Survival
chemical_list: D004280:Dobutamine