title: [Value of biomarkers in urology].
abstract: As part of the diagnosis and treatment of cancer objective biological measures are becoming increasingly important and may help to elicit the individual patient's risk of future outcome. Among theses measures are markers as determinants for the biological potential of the malignant disease, the prediction of recurrence after systemic treatment or the response to a specific therapy. In counselling patients with uro-oncologic diseases, the emerging role of evidence-based treatment choices reveals with cumulative certainty that the available information on markers is inconclusive.The aim of this review is to provide a summary of the current evidence of the evaluation of markers, which may be supportive for a treatment decision and/or provide additional valuable information as part of the treatment option. In addition, this may provide access to some of the most promising investigations, which may yield perspectives for future relevant clinical questions.
authors.affiliation: Urologische Klinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstr. 12, 91054, Erlangen, Deutschland. peter.goebell@uk-erlangen.de
authors.forename: P J
authors.initials: PJ
authors.lastname: Goebell
authors.forename: B
authors.initials: B
authors.lastname: Keck
authors.forename: S
authors.initials: S
authors.lastname: Wach
authors.forename: B
authors.initials: B
authors.lastname: Wullich
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D002292:Carcinoma, Renal Cell / Q000097:blood / Q000175:diagnosis / Q000235:genetics / Q000556:secondary / Q000628:therapy; D018450:Disease Progression; D019317:Evidence-Based Medicine; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D011237:Predictive Value of Tests; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D014565:Urogenital Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers