title: [Association of the ALOX5AP gene SG13S114 A/T polymorphism with atherosclerosis].
abstract: OBJECTIVE
  To investigate the relationship between the polymorphism of SG13S114 A/T in the 5-lipoxygenase-activating protein (ALOX5AP) gene and the stability of carotid atherosclerosis.
  
  
  METHODS
  Polymorphism of SG13S114 A/T in the ALOX5AP gene was analyzed in 152 cases of acute infarction with stable plaque, and 132 cases of acute infarction with vulnerable plaques, by using polymerase chain reaction and restriction fragment length polymorphism. Carotid artery plaque was analyzed by carotid artery color ultrasound.
  
  
  RESULTS
  The frequencies of SG13S114 AA genotype and the A allele in the vulnerable plaque group were higher than that in the stable plaque group (P< 0.01).
  
  
  CONCLUSIONS
  The polymorphism of SG13S114 A/T in the ALOX5AP gene may be associated with the instability of atherosclerosis. And the SG13S114 A allele may be a risk factor of vulnerable plaques.
authors.affiliation: Department of Neurology, Taizhou Hospital, Taizhou, Zhejiang, P.R. China. yinglei1525@126.com
authors.forename: Ying-lei
authors.initials: YL
authors.lastname: He
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Jin
authors.forename: Min
authors.initials: M
authors.lastname: Zhu
authors.forename: Xian-fang
authors.initials: XF
authors.lastname: Lin
authors.forename: Zong-lin
authors.initials: ZL
authors.lastname: Xie
authors.forename: Qiu-yue
authors.initials: QY
authors.lastname: Chen
mesh_terms: D058927:5-Lipoxygenase-Activating Proteins; D000368:Aged; D000369:Aged, 80 and over; D002340:Carotid Artery Diseases / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: D058927:5-Lipoxygenase-Activating Proteins; C548592:ALOX5AP protein, human; D002352:Carrier Proteins; D008565:Membrane Proteins