title: [Early relapse of hemophagocytic syndrome after reduced-intensity cord blood transplantation for relapsed acute lymphoblastic leukemia].
abstract: We report a 4-year-old girl who presented with acute onset of hemophagocytic syndrome (HPS) after induction therapy and HPS relapsed immediately after reduced-intensity cord blood transplantation (RI-CBT) for relapse of acute lymphoblastic leukemia. The patient underwent CBT from 2 locus-mismatched donor, after reduced-intensity conditioning therapy consisting of fludarabine, melphalan, and total body irradiation 4Gy. Prednisolone and cyclosporine were administered for prophylaxis against graft-versus-host disease. Bone marrow examination on day 20 revealed activated macrophages displaying hemophagocytosis. The origin of macrophages was 2(nd) donor derived. After administration of steroids, intravenous immunoglobulin and VP-16, the patient exhibited complete chimerism and remained in complete remission for over one year.
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Seishiro
authors.initials: S
authors.lastname: Nodomi
authors.forename: Itaru
authors.initials: I
authors.lastname: Kato
authors.forename: Tomoo
authors.initials: T
authors.lastname: Daifu
authors.forename: Satoshi
authors.initials: S
authors.lastname: Saida
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Morishima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsubara
authors.forename: Katsuji
authors.initials: K
authors.lastname: Umeda
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Watanabe
authors.forename: Etsuko
authors.initials: E
authors.lastname: Maruya
authors.forename: Hiroo
authors.initials: H
authors.lastname: Saji
authors.forename: Tatsutoshi
authors.initials: T
authors.lastname: Nakahata
authors.forename: Souichi
authors.initials: S
authors.lastname: Adachi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D005312:Fetal Blood / Q000637:transplantation*; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000209:etiology* / Q000628:therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012008:Recurrence; D012074:Remission Induction; D019172:Transplantation Conditioning; D016896:Treatment Outcome; D014916:Whole-Body Irradiation