title: In vitro / in vivo evaluation of NCDS-micro-fabricated biodegradable implant.
abstract: Using the nano-composite deposition system (NCDS) as a microfabrication technique, implantable scaffolds were prepared with poly(DL-lactide-co-glycolide)(85:15) [PLGA(85:15)] as a biodegradable polymer. 5-Fluorouracil (5-FU) was used as a model drug, and hydroxyapatite (HA) was incorporated as a release modifier. In vitro drug release was evaluated and we confirmed that HA could control the release of drug from the prepared scaffolds, especially in the initial phase of the release. Furthermore, in vivo tests demonstrated that the microfabricated scaffold with pores was useful in reducing immune response and maintained its original shape, indicating that the drug delivery system was highly biocompatible.
authors.affiliation: School of Mechanical, Sungkyunkwan University, Suwon, 440-746, Korea.
authors.forename: Chun-Woong
authors.initials: CW
authors.lastname: Park
authors.forename: Yun-Seok
authors.initials: YS
authors.lastname: Rhee
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Park
authors.forename: Son Dao
authors.initials: SD
authors.lastname: Danh
authors.forename: Sung-Hoon
authors.initials: SH
authors.lastname: Ahn
authors.forename: Sang-Cheol
authors.initials: SC
authors.lastname: Chi
authors.forename: Eun-Seok
authors.initials: ES
authors.lastname: Park
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D017886:Durapatite / Q000737:chemistry; D005472:Fluorouracil / Q000737:chemistry*; D005549:Foreign-Body Reaction / Q000276:immunology; D007249:Inflammation / Q000276:immunology; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry* / Q000276:immunology; D008297:Male; D008422:Materials Testing; D053761:Nanocomposites; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D016062:Porosity; D051381:Rats; D017207:Rats, Sprague-Dawley; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods; D054457:Tissue Scaffolds
chemical_list: D000964:Antimetabolites, Antineoplastic; D003692:Delayed-Action Preparations; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D017886:Durapatite; D005472:Fluorouracil