Association between transforming growth factor beta1 polymorphisms and atrial fibrillation in essential hypertensive subjects.
BACKGROUND
The association of TGF beta1 polymorphisms and atrial fibrillation (AF) in essential hypertensive (EH) subjects remains unknown. Methods EH subjects with AF (EH+AF+) and sinus rhythm (EH+AF-) were enrolled. The polymorphisms of +869 T --> C at codon 10 and + 915 G --> C at codon 25, were genotyped. The clinical characteristics including serum TGF beta1 levels were detected.


RESULTS
The GG genotypes of TGF beta1 +915 G --> C at codon 25 were more prevalent in subjects from EH+AF+ group than those from EH+AF- group (P = 0.009). The subjects with GG genotype from EH+AF+ group had the highest mean serum TGF beta1 level, which was significantly higher than that of GG genotype subjects from EH+AF- group (3.18 +/- 0.24 ng/dl vs.2.29 +/- 0.14 ng/dl, P < 0.05). Multiple analyses revealed that the TGF beta1 GG genotype of +915 G --> C at codon 25 presented a 3.09 times higher risk in developing AF in the multivariate model after adjusting for age and gender.


CONCLUSIONS
The polymorphisms of TGF beta1 +915 G --> C at codon 25 were associated with occurrence of AF and serum TGF beta1 level in EH subjects.
Wang
Yongzheng
Y
Department of Interventional Radiology, The Second Hospital of Shandong University, Shangdong, PR China.
Hou
Xuwei
X
Li
Yuliang
Y
D001281:Atrial Fibrillation / Q000235:genetics*; D003062:Codon; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D053773:Transforming Growth Factor beta1 / Q000097:blood / Q000235:genetics*
D003062:Codon; D053773:Transforming Growth Factor beta1