title: B cells have distinct roles in host protection against different nematode parasites.
abstract: B cells can mediate protective responses against nematode parasites by supporting Th2 cell development and/or by producing Abs. To examine this, B cell-deficient mice were inoculated with Nippostrongylus brasiliensis or Heligmosomoides polygyrus. B cell-deficient and wild type mice showed similar elevations in Th2 cytokines and worm expulsion after N. brasiliensis inoculation. Worm expulsion was inhibited in H. polygyrus-inoculated B cell-deficient mice, although Th2 cytokine elevations in mucosal tissues were unaffected. Impaired larval migration and development was compromised as early as day 4 after H. polygyrus challenge, and administration of immune serum restored protective immunity in B cell-deficient mice, indicating a primary role for Ab. Immune serum even mediated protective effects when administered to naive mice prior to inoculation. This study suggests variability in the importance of B cells in mediating protection against intestinal nematode parasites, and it indicates an important role for Ab in resistance to tissue-dwelling parasites.
authors.affiliation: Department of Medicine, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07101, USA.
authors.forename: Qian
authors.initials: Q
authors.lastname: Liu
authors.forename: Timothy
authors.initials: T
authors.lastname: Kreider
authors.forename: Scott
authors.initials: S
authors.lastname: Bowdridge
authors.forename: Zhugong
authors.initials: Z
authors.lastname: Liu
authors.forename: Youngmia
authors.initials: Y
authors.lastname: Song
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Gaydo
authors.forename: Joseph F
authors.initials: JF
authors.lastname: Urban
authors.forename: William C
authors.initials: WC
authors.lastname: Gause
mesh_terms: D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000469:parasitology* / Q000637:transplantation; D005260:Female; D006790:Host-Parasite Interactions / Q000276:immunology*; D007156:Immunologic Memory; D051379:Mice; D008807:Mice, Inbred BALB C; D008817:Mice, Mutant Strains; D009351:Nematospiroides dubius / Q000254:growth & development / Q000276:immunology*; D009559:Nippostrongylus / Q000254:growth & development / Q000276:immunology*; D017206:Strongylida Infections / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D018418:Th2 Cells / Q000276:immunology / Q000469:parasitology / Q000473:pathology