title: Towards a molecular understanding of sex differences in memory formation.
abstract: Sex differences exist in brain function and behavior. However, the underlying molecular mechanisms are only beginning to emerge. Recent studies in rodents have revealed molecular mechanisms underlying sex differences in memory formation. It is becoming clear that sex differences are not simply reflective of differences in sex hormones, but also reflect distinctions in synaptic signaling mechanisms including the role of synaptic kinases. Furthermore, there are sex differences in the activation of transcription factors and gene transcription during memory formation. This review discusses emerging evidence in the field and how these findings are providing a first step towards a molecular understanding of how sex differences impact on memory formation both in health and disease.
authors.affiliation: King's College London, Institute of Psychiatry, Department of Neuroscience, London SE5 9NU, UK. keiko.mizuno@kcl.ac.uk
authors.forename: Keiko
authors.initials: K
authors.lastname: Mizuno
authors.forename: K Peter
authors.initials: KP
authors.lastname: Giese
mesh_terms: D000818:Animals; D012739:Gonadal Steroid Hormones / Q000235:genetics; D006801:Humans; D008568:Memory / Q000502:physiology*; D008954:Models, Biological; D012728:Sex Chromatin / Q000235:genetics*; D012737:Sex Factors; D013569:Synapses / Q000235:genetics* / Q000502:physiology
chemical_list: D012739:Gonadal Steroid Hormones