Decoding the function of nuclear long non-coding RNAs.
Long non-coding RNAs (lncRNAs) are mRNA-like, non-protein-coding RNAs that are pervasively transcribed throughout eukaryotic genomes. Rather than silently accumulating in the nucleus, many of these are now known or suspected to play important roles in nuclear architecture or in the regulation of gene expression. In this review, we highlight some recent progress in how lncRNAs regulate these important nuclear processes at the molecular level.
Chen
Ling-Ling
LL
Department of Genetics and Developmental Biology, University of Connecticut Stem Cell Institute, Farmington, CT 06030-3301, USA. linchen@uchc.edu
Carmichael
Gordon G
GG
D000818:Animals; D002467:Cell Nucleus / Q000235:genetics*; D042002:Chromatin Assembly and Disassembly; D005786:Gene Expression Regulation; D006801:Humans; D015138:RNA, Nuclear / Q000378:metabolism*; D022661:RNA, Untranslated / Q000378:metabolism*; D014158:Transcription, Genetic
D015138:RNA, Nuclear; D022661:RNA, Untranslated