title: Label-free and naked eye detection of PNA/DNA hybridization using enhancement of gold nanoparticles.
abstract: Utilizing a gold enhancement process after inducing electrostatic interaction between positively charged gold nanoparticles and negatively charged target DNA hybridized to neutral PNA capture probes, a new method for label-free detection of DNA was developed and successfully applied to detect H5-type DNA.
authors.affiliation: BioNanotechnology Research Center, Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yuseong, Daejeon 305-600, Republic of Korea.
authors.forename: Sang Kyu
authors.initials: SK
authors.lastname: Kim
authors.forename: Hyunmin
authors.initials: H
authors.lastname: Cho
authors.forename: Jinyoung
authors.initials: J
authors.lastname: Jeong
authors.forename: Ji Na
authors.initials: JN
authors.lastname: Kwon
authors.forename: Yongwon
authors.initials: Y
authors.lastname: Jung
authors.forename: Bong Hyun
authors.initials: BH
authors.lastname: Chung
mesh_terms: D004247:DNA / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D017403:In Situ Hybridization; D053768:Metal Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D055672:Static Electricity; D013499:Surface Properties
chemical_list: D020135:Peptide Nucleic Acids; D006046:Gold; D004247:DNA