title: Expression of syncytin in leukemia and lymphoma cells.
abstract: Syncytin is a placenta-specific protein and generally believed to play a pivotal role in syncytiotrophoblast morphogenesis. In this study, transcripts of this gene were quantified by real-time RT-PCR and the translated products were measured by an indirect immunofluorescence assay. Results showed that syncytin was found to be expressed in all nine leukemia and lymphoma cell lines studied albeit at different levels and in 43 peripheral blood samples of 57 leukemia or lymphoma patients. Neither the transcripts nor the translated syncytin was detected in blood samples of normal individuals. In conclusion, peripheral blood syncytin may serve as a marker for leukemia and lymphoma.
authors.affiliation: Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, 32 Jiaochang Donglu, Kunming 650223, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Sun
authors.forename: Dong-Yun
authors.initials: DY
authors.lastname: Ouyang
authors.forename: Wei
authors.initials: W
authors.lastname: Pang
authors.forename: Yuan-Quan
authors.initials: YQ
authors.lastname: Tu
authors.forename: Yu-Ye
authors.initials: YY
authors.lastname: Li
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Shen
authors.forename: Siu-Cheung
authors.initials: SC
authors.lastname: Tam
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Yang
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
mesh_terms: D015153:Blotting, Western; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D015686:Gene Products, env / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007938:Leukemia / Q000378:metabolism* / Q000473:pathology; D008223:Lymphoma / Q000378:metabolism* / Q000473:pathology; D008297:Male; D011257:Pregnancy Proteins / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D015686:Gene Products, env; D011257:Pregnancy Proteins; D012333:RNA, Messenger; C405335:syncytin