A highly selective and sensitive fluorescent probe for Hg(2+) imaging in live cells based on a rhodamine-thioamide-alkyne scaffold.
A new fluorescence turn-on probe for Hg(2+) imaging in living cells was judiciously designed based on the interactions of Hg(2+) to both thiol and alkyne moieties in a rhodamine scaffold, and the likely novel sensing mechanism has been proposed.
Lin
Weiying
W
State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, Hunan 410082, PR China. weiyinglin@hnu.cn
Cao
Xiaowei
X
Ding
Yundi
Y
Yuan
Lin
L
Long
Lingliang
L
D000480:Alkynes / Q000737:chemistry*; D002460:Cell Line; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D008628:Mercury / Q000032:analysis*; D015394:Molecular Structure; D012235:Rhodamines / Q000737:chemistry*; D013237:Stereoisomerism; D013854:Thioamides / Q000737:chemistry*
D000480:Alkynes; D005456:Fluorescent Dyes; D012235:Rhodamines; D013854:Thioamides; D008628:Mercury