title: IL-17 is elevated in cerebrospinal fluids in bacterial meningitis in children.
abstract: Bacterial meningitis has a poor prognosis and neurologic complications. The present study aimed to investigate the cytokine/chemokine network in cerebrospinal fluid (CSF) from children with bacterial meningitis and aseptic meningitis. Interleukin (IL)-1beta, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12, IL-13, IL-17, interferon-gamma, tumor necrosis factor-alpha, granulocyte colony-stimulating factor, granulocyte monocyte colony-stimulating factor, monocyte chemoattractant protein-1 and macrophage inflammatory protein-1beta, were measured simultaneously in CSF supernatants. We found that, IL-17 was significantly elevated in CSF with bacterial meningitis. We believe that IL-17 plays a key role in neutrophil infiltration into CSF and neuronal protection in bacterial meningitis.
authors.affiliation: Department of Pediatrics, Nippon Medical School, Chiba Hokusoh Hospital, Chiba-Pref 270-1694, Japan. VFF13540@nifty.ne.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Asano
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Ichiki
authors.forename: Shinya
authors.initials: S
authors.lastname: Koizumi
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Kaizu
authors.forename: Takayuki
authors.initials: T
authors.lastname: Hatori
authors.forename: Osamu
authors.initials: O
authors.lastname: Fujino
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Mashiko
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Taku
authors.initials: T
authors.lastname: Miyasho
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Fukunaga
mesh_terms: D018925:Chemokines / Q000097:blood / Q000134:cerebrospinal fluid; D002648:Child; D003710:Demography; D005334:Fever / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications; D006801:Humans; D020381:Interleukin-17 / Q000097:blood / Q000134:cerebrospinal fluid*; D008582:Meningitis, Aseptic / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications; D016920:Meningitis, Bacterial / Q000097:blood / Q000134:cerebrospinal fluid* / Q000150:complications
chemical_list: D018925:Chemokines; D020381:Interleukin-17