[Haematological abnormalities in premature babies due to placental mesenchymal dysplasia].
Two premature babies were admitted separately to the Neonatal Intensive Care Unit. One patient, a girl, presented with severe anaemia and thrombocytopaenia, the other, another girl, showed isolated thrombocytopaenia. During both pregnancies, ultrasound showed abnormalities of the placenta. The first patient also had intra-uterine growth restriction. A postpartum pathological examination showed abnormalities of both placentae consistent with placental mesenchymal dysplasia. Placental mesenchymal dysplasia is a rare condition which is associated with intra-uterine growth restriction, intra-uterine mortality, prematurity and Beckwith-Wiedemann syndrome. Thrombocytopaenia and anaemia are less commonly described in literature and are caused by micro-angiopathic haemolysis in the placenta. Both children had unrestricted growth and development patterns at one year and 6 months follow-up, respectively.
Sengers
Florien B
FB
Máxima Medisch Centrum, Veldhoven, afd. Kindergeneeskunde en Neonatologie, Veldhoven, The Netherlands. florien_s@hotmail.com
van Lijnschoten
Gesina
G
van der Sluijs-Bens
Jacqueline P
JP
Porath
Martina M
MM
Dijkman
Koen P
KP
D003937:Diagnosis, Differential; D005260:Female; D005317:Fetal Growth Retardation / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008208:Lymphatic System / Q000000981:diagnostic imaging / Q000473:pathology*; D008648:Mesoderm / Q000000981:diagnostic imaging / Q000473:pathology*; D010920:Placenta / Q000000981:diagnostic imaging / Q000473:pathology*; D010922:Placenta Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D016216:Ultrasonography, Prenatal