Cross-talk of alloimmune response and autoimmunity: role in pathogenesis of chronic rejection.
Chronic rejection following organ transplantation continues to be a major problem in the long-term survival of the engraftment. Recent literature points to role of both the humoral and cellular alloimmune responses in the pathogenesis of chronic rejection. Our recent studies have provided evidence for alloimmune-response-induced de novo development of immune responses to self-antigens in the post-transplant period in the pathogenesis of chronic rejection following lung, heart, and kidney transplantation. This review details our current understanding of two distinct yet inter-dependent immune processes in the immunopathogenesis of chronic rejection.
Tiriveedhi
Venkataswarup
V
Department of Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA. kumart@wustl.edu
Weber
Joseph
J
Seetharam
Anil
A
Mohanakumar
Thalachallour
T
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis; D015551:Autoimmunity; D002908:Chronic Disease; D006084:Graft Rejection / Q000209:etiology*; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D008954:Models, Biological
D001323:Autoantibodies; D007518:Isoantibodies