Brønsted acid-catalyzed cascade cycloisomerization of enynes via acetylene cations and sp3-hybridized C-H bond activation.
A novel Brønsted acid-catalyzed cascade cycloisomerization of cyclic and acyclic enynes via acetylene cation cyclization followed by cleavage of the entirely inactive C(sp(3))-H bond is described. The reaction proceeds efficiently under mild conditions to afford various tri- and bicyclic compounds in good to high yields.
Jin
Tienan
T
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan. tjin@mail.tains.tohoku.ac.jp
Himuro
Masafumi
M
Yamamoto
Yoshinori
Y