title: Chlorin e6-cholesterol conjugate and its copper complex. Simple synthesis and entrapping in phospholipid vesicles.
abstract: Synthesis of 13'[(cholest-5-en)-3beta-yloxyethoxycarbamoyl]-chlorin e6 starting from methylpheophorbide and 3beta(2-hydroxy)-ethoxycholest-5-ene is presented, as well as the preparation of related copper complex. Both conjugates obtained may be simply incorporated in phosphatidyl choline vesicles.
authors.affiliation: V.N. Orekhovich Institute of Biomedical Chemistry RAMS, Moscow, Russia.
authors.forename: Irina A
authors.initials: IA
authors.lastname: Nikolaeva
authors.forename: Alexander Yu
authors.initials: AY
authors.lastname: Misharin
authors.forename: Gelii V
authors.initials: GV
authors.lastname: Ponomarev
authors.forename: Vladimir P
authors.initials: VP
authors.lastname: Timofeev
authors.forename: Yaroslav V
authors.initials: YV
authors.lastname: Tkachev
mesh_terms: D002735:Chlorophyllides; D002784:Cholesterol / Q000737:chemistry*; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011166:Porphyrins / Q000737:chemistry*
chemical_list: D002735:Chlorophyllides; D056831:Coordination Complexes; D008051:Lipid Bilayers; D017319:Photosensitizing Agents; D011166:Porphyrins; C062985:phytochlorin; D003300:Copper; D002784:Cholesterol