Primary adenomyoepithelioma of tonsil.
We present a case of adenomyoepithlioma (AME) arising from the tonsil. AME is an uncommon tumor that typically arises in breast, but rarely found in salivary glands, lung, and skin. Its biological features have not been thoroughly characterized. Here we describe a primary AME originating from the tonsil. The pathologic changes were characterized by hypercellularity, the dominance of both epithelial and myoepithelial cells. Malignancy was evidenced by the presence of a high mitotic rate and invasive growth. The epithelial cells express high levels of cytokeratin and epithelial membrane antigen (EMA). The myoepithelial cells show positive staining for calponin, p63, vimentin, and S-100. A thorough review of the literature indicates that this is likely the first reported case of AME from the tonsil. Following descriptions of the diagnosis, treatment, and prognosis of this specific case, pathologic and clinical characteristics of AME from other tissues are also compiled and discussed.
Ren
Juan
J
Cancer center, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
Song
Liping
L
Cancer center, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
Dang
Qiang
Q
Medical school of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, PR China.
Zhang
Xiaozhi
X
Cancer center, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
Jiang
Shi-Wen
SW
Department of Basic Biomedical Sciences, Mercer University School of Medicine, GA 31404, USA.|Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN 55905, USA.
Zhang
Guanjun
G
Cancer center, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
Wang
Ning
N
Medical school of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, PR China.
Liu
Zi
Z
Cancer center, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
Wang
Jiansheng
J
Cancer center, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
Hwa
Yi Lisa
YL
Department of Internal Medicine, Mayo Clinic, MN, 55905, USA.
Li
Zongfang
Z
Second Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
Zhao
Xinhan
X
Cancer center, First Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaan'xi Province, 710061 PR China.
Liu
Yuan
Y
Department of pathology, Dental Hospital, Fourth Military Medical University, 710038 PR China.
D055331:Adenomyoepithelioma / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D014067:Tonsillar Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000628:therapy