title: INSIG2 is Associated with Lower Gain in Weight-for-Length Between Birth and Age 6 Months.
abstract: Researchers have described the association of a common DNA polymorphism, rs7566605, near INSIG2 (insulin-induced gene 2) with obesity in multiple independent populations that include subjects ages 11-60 years.1 To our knowledge, no studies have examined the association of this polymorphism with weight status during early childhood. We explored the association of the rs7566605 polymorphism with weight-for-length among 319 children at 6 months and 3 years participating in Project Viva, a pre-birth cohort study. In contrast to studies of older individuals, CC homozygosity was associated with lower gain in weight-for-length z-score between birth and age 6 months than GG homozygosity or GC heterozygosity. At age 3, we did not find an association. The association of INSIG2 gene with obesity may change direction with age.
authors.affiliation: Center for Child Health Care Studies, Department of Ambulatory Care and Prevention, Harvard Pilgrim Health Care and Harvard Medical School, Boston, Massachusetts, U.S.A.
authors.forename: Ann Chen
authors.initials: AC
authors.lastname: Wu
authors.forename: Matthew W
authors.initials: MW
authors.lastname: Gillman
authors.forename: Elsie M
authors.initials: EM
authors.lastname: Taveras
authors.forename: Augusto A
authors.initials: AA
authors.lastname: Litonjua