title: Chaperoning ribosome assembly.
abstract: Chaperones help proteins fold in all cellular compartments, and many associate directly with ribosomes, capturing nascent chains to assist their folding and prevent aggregation. In this issue, new data from Koplin et al. (2010. J. Cell Biol. doi: 10.1083/jcb.200910074) and Albanèse et al. (2010. J. Cell Biol. doi: 10.1083/jcb.201001054) suggest that in addition to promoting protein folding, the chaperones ribosome-associated complex (RAC), nascent chain-associated complex (NAC), and Jjj1 also help in the assembly of ribosomes.
authors.affiliation: Department of Chemistry and 2 Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA. kkarbst@umich.edu
authors.forename: Katrin
authors.initials: K
authors.lastname: Karbstein
mesh_terms: D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism*; D017510:Protein Folding; D012270:Ribosomes / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D018832:Molecular Chaperones; D029701:Saccharomyces cerevisiae Proteins