title: Microarray analysis of the liver in metallothionein-III null mice treated with cadmium.
abstract: In order to elucidate the effect of metallothionein (MT)-III on hepatic gene expression altered by cadmium (Cd), we examined gene expression patterns in the liver of MT-III null mice and wild-type mice after Cd injection using a DNA microarray containing 35,852 genes. In a comparison between Cd-injected MT-III null mice and Cd-injected wild-type mice, 9 genes were found to be up-regulated and 28 genes-including serum amyloid A1 (SAA-1) and SAA-2--were down-regulated.
authors.affiliation: Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University, Nagoya, Aichi, Japan.
authors.forename: Akiko
authors.initials: A
authors.lastname: Honda
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Komuro
authors.forename: Hisamitsu
authors.initials: H
authors.lastname: Nagase
authors.forename: Isao
authors.initials: I
authors.lastname: Hozumi
authors.forename: Takashi
authors.initials: T
authors.lastname: Inuzuka
authors.forename: Hideaki
authors.initials: H
authors.lastname: Hara
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Fujiwara
authors.forename: Masahiko
authors.initials: M
authors.lastname: Satoh
mesh_terms: D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D000090023:Metallothionein 3; D051379:Mice; D009419:Nerve Tissue Proteins / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D000685:Serum Amyloid A Protein / Q000032:analysis
chemical_list: D000090023:Metallothionein 3; D009419:Nerve Tissue Proteins; D000685:Serum Amyloid A Protein; D002104:Cadmium