title: [Influencing factors for cerebral microbleeds in patients with acute ischemic stroke].
abstract: OBJECTIVE
  To investigate the relationship between cerebral microbleeds (CMB), cardiovascular risk factors, and plasma fibrinogen in patients with acute ischemic stroke.
  
  
  METHODS
  Sixty-eight patients with acute ischemic stroke from June 2008 to March 2009 were enroued prospectively. All patients received cranial magnetic resonance imaging at the first week, and T2(*)-weighted gradient echo MRI sequence was performed to detect CMB. Plasma fibrinogen, uric acid levels and other biochemical parameters were measured on the next day of admission. All data were selected from Nanjing Stroke Registry Program.
  
  
  RESULTS
  Among a total 68 patients, 29 (43%) patients had 109 lesions of cerebral microbleeds on gradient-echo MRI. Age, hypertension, fibrinogen and uric acid were significantly associated with the presence of CMB (P = 0.004, 0.024, 0.020, 0.027 respectively). Through a logistic regression analysis, age, hypertension and plasma fibrinogen were significantly associated with the presence of cerebral microbleeds [(P = 0.02, OR = 1.10, 95%CI 1.02 to 1.19; P = 0.003, OR = 9.35, 95%CI 2.17 to 40.23; P = 0.019, OR = 1.01, 95%CI 1.00 to 1.02].
  
  
  CONCLUSIONS
  There is a high prevalence of CMB in patients with acute ischemic stroke. And it has a strong relationship with high plasma fibrinogen.
authors.affiliation: Department of Neurology, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China.
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Zhou
authors.forename: Song
authors.initials: S
authors.lastname: Yang
authors.forename: Xuan-Ye
authors.initials: XY
authors.lastname: Yue
authors.forename: Wu-Sheng
authors.initials: WS
authors.lastname: Zhu
authors.forename: Min-Min
authors.initials: MM
authors.lastname: Ma
authors.forename: Ge-Lin
authors.initials: GL
authors.lastname: Xu
authors.forename: Xin-Feng
authors.initials: XF
authors.lastname: Liu
mesh_terms: D000368:Aged; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000150:complications* / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000209:etiology* / Q000473:pathology; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D020521:Stroke / Q000150:complications*
chemical_list: D005340:Fibrinogen