[Research on liposoluble ingredients of Quchiling].
OBJECTIVE
To study the liposoluble ingredients of Quchiling (LQ), which enter the blood and the brain,and to confirm the active ingredients of LQ in vivo.


METHODS
Serum pharmacochemistry and gas chromatography mass spectroscopy were used to analyze ingredients of LQ entering the blood and the brain.


RESULTS
There were eleven ingredients of LQ to enter the blood and six ingredients of LQ to enter the brain.


CONCLUSIONS
It is confirmed that eleven ingredients of LQ entered the blood, which are beta-asarone, schisandrol A, schisandrol B, deoxyschisandrin, schisandrin B, schisantherrin A, schisantherrin B, schisantherrin C, delta-cadinene, delta-cadinol and calamendiol in the blood, and that six ingredients are beta-asarone, schisandrol A, schisandrol B, deoxyschisandrin, schisandrin B and calamendiol in the brain.
Weng
Wen
W
Neuropharmacological Research Laboratory, College of Pharmacy, Jinan University, Guangzhou 510632, China. qyk968150@office.jnu.edu.cn
Xiao
Fei
F
Li
Xiaoguang
X
Gao
Qin
Q
Luo
Huanmin
H
D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000737:chemistry / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D034242:Cyclooctanes / Q000737:chemistry / Q000378:metabolism; D004149:Dioxoles / Q000737:chemistry / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D017705:Lignans / Q000737:chemistry / Q000378:metabolism; D008297:Male; D011083:Polycyclic Compounds / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D034242:Cyclooctanes; D004149:Dioxoles; D004365:Drugs, Chinese Herbal; D017705:Lignans; D011083:Polycyclic Compounds; C012195:asarone; C520474:schisandrol A; C015499:schizandrin B; C033585:schizandrol B; C034734:schizandrin A