title: Diagnostics and treatment of spontaneous intracranial hypotension.
abstract: OBJECTIVE
  Intracranial hypotension is a frequently misdiagnosed syndrome which is caused by reduced intracranial cerebrospinal fluid (CSF) pressure due to spontaneous spinal CSF leakage. We present our series of intracranial hypotension regarding especially the required diagnostic imaging and the treatment.
  
  
  METHODS
  A retrospective analysis was performed on 8 patients (5 males, 3 females, mean age 49 years) with postural and non-postural headache due to spinal CSF collection.
  
  
  RESULTS
  Cranial MRI showed diffuse pachymeningeal gadolinium enhancement in all cases. CSF leakage detected by gadolinium-enhanced MR cisternography could be either diffuse (n=5) or precisely located around a dural tear (n=3). All but one leakages were located at the thoracic spine. In 6 patients 40-65 mL of blood were injected through epidurally placed drainages. In 1 patient, a dural tear was sealed with fibrin glue and fat. One patient refused surgical intervention. One epidural haematoma had to be revised. 5 of 7 patients showed excellent results.
  
  
  CONCLUSIONS
  Gadolinium-enhanced MR cisternography best revealed CSF leaks. In the majority of patients with spontaneous intracranial hypotension, complete recovery may be achieved via a midthoracic epidural blood patch with minimal complications.
authors.affiliation: Clinic of Neurological Surgery, Wedau Kliniken Duisburg, Duisburg, Germany. Uta_Schick@web.de
authors.forename: U
authors.initials: U
authors.lastname: Schick
authors.forename: C
authors.initials: C
authors.lastname: Musahl
authors.forename: K
authors.initials: K
authors.lastname: Papke
mesh_terms: D000328:Adult; D017217:Blood Patch, Epidural; D003287:Contrast Media / Q000008:administration & dosage; D003937:Diagnosis, Differential; D004388:Dura Mater / Q000293:injuries / Q000601:surgery; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D019786:Gadolinium DTPA; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007278:Injections, Spinal; D019585:Intracranial Hypotension / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery*; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009192:Myelography; D009460:Neurologic Examination; D011183:Postoperative Complications / Q000209:etiology; D012189:Retrospective Studies; D013353:Subdural Effusion / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery*; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media; D015718:Fibrin Tissue Adhesive; D019786:Gadolinium DTPA