title: Alcohol absorption modification after a laparoscopic sleeve gastrectomy due to obesity.
abstract: BACKGROUND
  The different bariatric surgery techniques that alter the digestive anatomy also modify the gastric absorption surface. Since alcohol is a substance that is mainly metabolized in the stomach, the goal of this study was to determine alcohol absorption before and after a laparoscopic sleeve gastrectomy (LSG) in the same patients.
  
  
  METHODS
  Studies were carried out on 12 morbidly obese patients who underwent a LSG (eight men and four women). Each patient was given 3.6 ml of red wine to drink at 14% for each liter of body water mass. Alcotest values (Alcoscan Alcomate AL-6000) were measured 10 min after the wine dose had been consumed. Measurements were then repeated every 5 min until the alcohol had been completely eliminated from the bloodstream. During the postoperatory period (median of 2.3 months), the measurement was repeated with the total dose per kg adjusted to the new water body mass. The results were measured with a nonparametric analysis for repeated samples.
  
  
  RESULTS
  The maximum average peak of the Alcotest was 2.02 g/l during the postoperative period compared to 0.87 g/l during the preoperative period (p = 0.001 Wilcoxon). At 175 min, the blood alcohol level value reaches zero (0) in all pre-operatory patients, while after surgery, an average value of 0.26 g/l was observed (p = 0.027 Wilcoxon). After 4 h, an Alcotest average of 0.20 g/l was observed in these patients.
  
  
  CONCLUSIONS
  Alcohol absorption was considerably modified after LSG with higher and longer blood alcohol values for equivalent amounts of alcohol.
authors.affiliation: Department of Surgery, German Clinic of Santiago, Santiago, Chile. fmaluenda@alemana.cl
authors.forename: Fernando
authors.initials: F
authors.lastname: Maluenda
authors.forename: Attila
authors.initials: A
authors.lastname: Csendes
authors.forename: Xabier
authors.initials: X
authors.lastname: De Aretxabala
authors.forename: Jaime
authors.initials: J
authors.lastname: Poniachik
authors.forename: Karen
authors.initials: K
authors.lastname: Salvo
authors.forename: Iris
authors.initials: I
authors.lastname: Delgado
authors.forename: Patricia
authors.initials: P
authors.lastname: Rodriguez
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000378:metabolism*; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics; D005260:Female; D005743:Gastrectomy / Q000009:adverse effects* / Q000379:methods; D006801:Humans; D010535:Laparoscopy / Q000379:methods; D008297:Male; D009767:Obesity, Morbid / Q000378:metabolism*; D013997:Time Factors; D016896:Treatment Outcome; D014920:Wine
chemical_list: D000431:Ethanol