[Telomeres and telomerase: relevance and future prospects in systemic lupus erythematosus].
Telomeres are specialized structures that cap and protect the end of chromosomes. Telomeres progressively shorten after each cellular division unless an enzyme, the telomerase, counteracts. Telomeres are implicated in cellular senescence, acting like a biological clock. Telomere length and telomerase activity are important in the physiopathology of cancer. In the past years, research has focused on them in order to find new therapeutic targets. Yet, oxidative stress, inflammation and increased leucocytes renewal are major environmental factors associated with telomeres shortening acceleration and thus in concordance with biological age. Thus, telomeric erosion induces cell apoptosis; indeed, apoptotic cell clearance is impaired in systemic lupus. Considering these elements and data resulting from oncology, telomere/telomerase couple was studied during the last decade in systemic lupus erythematosus. The objective was to know if this couple could have an implication in the physiopathology of this disease. A systematic review of literature is proposed about telomere and/or telomerase in systemic lupus erythematosus in order to discuss their physiopathological implication. Among 273 tested patients, telomere seems to be eroded and telomerase activity insufficiently increased but correlated to the activity of the disease. The analysis of telomere length and telomerase activity could be useful as prognosis factor or disease activity index. Telomere erosion could reflect an accelerated replicative senescence of the immune system. The role of the regulator T lymphocytes has not yet been precised. Standardized studies on larger population could be realized in systemic lupus and open new avenues of research and/or therapy based upon the telomere/telomerase biology.
Georgin-Lavialle
S
S
Service d'hématologie adultes, hôpital Necker, UMR CNRS 8147, centre de référence des mastocytoses, faculté de médecine, université Paris Descartes, 161, rue de Sèvres, 75015 Paris, France.
Aouba
A
A
Lepelletier
Y
Y
Gabet
A-S
AS
Hermine
O
O
D017209:Apoptosis / Q000235:genetics; D015415:Biomarkers / Q000378:metabolism; D016922:Cellular Senescence / Q000235:genetics; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D018384:Oxidative Stress / Q000235:genetics; D011379:Prognosis; D012307:Risk Factors; D012720:Severity of Illness Index; D019098:Telomerase / Q000096:biosynthesis*; D016615:Telomere / Q000378:metabolism*
D015415:Biomarkers; D019098:Telomerase