title: Isolation and structure elucidation of an interaction product of aminotadalafil found in an illegal health food product.
abstract: An interaction product of aminotadalafil was isolated from an illegal health food product. The structure of the interaction product was elucidated by means of IR, NMR, and mass spectroscopy. The hitherto unknown compound was characterized as condensation product of aminotadalafil and hydroxymethylfuraldehyde and is probably the result of a drug-excipient incompatibility.
authors.affiliation: Official Medicines Control Laboratory, Swissmedic, Hallerstrasse 7, CH-3000 Berne 9, Switzerland.
authors.forename: Adrian
authors.initials: A
authors.lastname: Häberli
authors.forename: Philippe
authors.initials: P
authors.lastname: Girard
authors.forename: Min-Yong
authors.initials: MY
authors.lastname: Low
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Ge
mesh_terms: D052117:Benzodioxoles / Q000737:chemistry*; D002243:Carbolines / Q000737:chemistry*; D004340:Drug Contamination; D004344:Drug Incompatibility; D058870:Food, Organic / Q000032:analysis*; D005662:Furaldehyde / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D015394:Molecular Structure; D013055:Spectrophotometry, Infrared
chemical_list: D052117:Benzodioxoles; D002243:Carbolines; D005662:Furaldehyde; C551065:aminotadalafil