title: Folate conjugated poly(ester amine) for lung cancer therapy.
abstract: Folate conjugated poly(ester amine) (PEA) was prepared by reaction of folic acid with PEAs based on polycaprolactone (PCL) and low molecular weight polyethylenimine (LMW-PEI) with PEG as a linker. This novel gene carrier showed excellent physicochemical properties and relatively low cytotoxicity compared with PEI 25K. It showed excellent transfection efficiency through folate receptor mediated endocytosis.
authors.affiliation: School of Agricultural Biotechnology, Seoul National University, Seoul 151-921, Korea.
authors.forename: Rohidas B
authors.initials: RB
authors.lastname: Arote
authors.forename: Mi-Kyong
authors.initials: MK
authors.lastname: Yoon
authors.forename: Tae-Hee
authors.initials: TH
authors.lastname: Kim
authors.forename: Dhananjay
authors.initials: D
authors.lastname: Jere
authors.forename: Hu-Lin
authors.initials: HL
authors.lastname: Jiang
authors.forename: You-Kyoung
authors.initials: YK
authors.lastname: Kim
authors.forename: In-Kyu
authors.initials: IK
authors.lastname: Park
authors.forename: Chong-Su
authors.initials: CS
authors.lastname: Cho
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005492:Folic Acid / Q000008:administration & dosage* / Q000737:chemistry*; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D046911:Macromolecular Substances / Q000737:chemistry; D008422:Materials Testing; D008968:Molecular Conformation; D053769:Nanocapsules / Q000737:chemistry* / Q000648:ultrastructure; D050997:Nanomedicine / Q000379:methods*; D011091:Polyesters / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D000970:Antineoplastic Agents; D046911:Macromolecular Substances; D053769:Nanocapsules; D011091:Polyesters; C016240:polycaprolactone; D005492:Folic Acid