title: [Effect of Arg-Gly-Asp peptide on the secretion of vascular endothelial growth factor from vascular endothelial cells].
abstract: OBJECTIVE
  To investigate the effect of Arg-Gly-Asp peptides (RGD peptides)on the secretion of vascular endothelial growth factor (VEGF) from vascular endothelial cells (VEC) and the mechanism.
  
  
  METHODS
  Using VEC cultured from the arteries of human greater omentum as a model, and detecting the content of VEGF and the activity of protein kinase C (PKC) under different concentration of RGD.
  
  
  RESULTS
  After incubation with 100-300 mg/ml of RGD peptide for 24h, the VEGF content and the activity of PKC in experimental group was significantly higher than that in control group (P < 0.01).
  
  
  CONCLUSIONS
  The stimulation of RGD peptide to the secretion of VEGF from VEC is in a dose-dependent way, and the stimulation is regulated by activating PKC.
authors.affiliation: School of Nursing, Jilin Medical College, Jilin 132013, China. georgina27@sina.com
authors.forename: Qing
authors.initials: Q
authors.lastname: Guan
authors.forename: Zhongyan
authors.initials: Z
authors.lastname: Li
authors.forename: Soban
authors.initials: S
authors.lastname: Uumar
authors.forename: Shijie
authors.initials: S
authors.lastname: Lü
mesh_terms: D001158:Arteries / Q000166:cytology; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D009842:Oligopeptides / Q000494:pharmacology*; D009852:Omentum / Q000098:blood supply; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D009842:Oligopeptides; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C047981:arginyl-glycyl-aspartic acid