title: [To investigate the overexpression of Stat3 and Cyclin D1 in laryngeal neoplasm by immunohistochemistry].
abstract: OBJECTIVE
  To investigate the overexpression of Stat3 and Cyclin D1 in laryngeal neoplasm with immunohistochemistry method.
  
  
  METHODS
  With immunohistochemistry method, we investigated the expression of Stat3 and Cyclin D1 in laryngeal neoplasm and analysis the relationship between Stat3 and clinical pathological factor.
  
  
  RESULTS
  Stat3 and Cyclin D1 overexpressed in laryngeal neoplasm tissue and they have positive relationship.
  
  
  CONCLUSIONS
  Active Stat3 may promote the transcription of target gene Cyclin D1, which could accelerate carcinomatous change.
authors.affiliation: Department of Otolaryngology, Shengjing Hospital, China Medical University, Shenyang, 110004, China.
authors.forename: Hongjun
authors.initials: H
authors.lastname: Liang
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Wenyue
authors.initials: W
authors.lastname: Ji
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D019938:Cyclin D1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D050796:STAT3 Transcription Factor / Q000378:metabolism*
chemical_list: C530104:CCND1 protein, human; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D019938:Cyclin D1