The beneficial effects of olibanum on memory deficit induced by hypothyroidism in adult rats tested in Morris water maze.
Functional consequences of hypothyroidism include impaired learning and memory and inability to produce long-term potentiation (LTP) in hippocampus. Olibanum has been used for variety of therapeutic purposes. In traditional medicine, oilbanum is used to enhance learning and memory. In the present study the effect of olibanum on memory deficit in hypothyroid rats was investigated. Male wistar rats were divided into four groups and treated for 180 days. Group 1 received tap drinking water while in group 2, 0.03% methimazol was added to drinking water. Group 3 and 4 were treated with 0.03% methimazole as well as 100 and 500 mg/kg olibanum respectively. The animals were tested in Morris water maze. The swimming speed was significantly lower and the distance and time latency were higher in group 2 compared with group 1. In groups 3 and 4 the swimming speed was significantly higher while, the length of the swim path and time latency were significantly lower in comparison with group 2. It is concluded that methimazole-induced hypothyroidism impairs learning and memory in adult rats which could be prevented by using olibanum.
Hosseini
Mahmoud
M
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran. hosseinim@MUMS.ac.ir
Hadjzadeh
Mosa Al-Reza
MA
Derakhshan
Mohammad
M
Havakhah
Shahrzad
S
Rassouli
Fatemeh Behnam
FB
Rakhshandeh
Hassan
H
Saffarzadeh
Fatema
F
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D029743:Boswellia; D004195:Disease Models, Animal; D007037:Hypothyroidism / Q000139:chemically induced / Q000188:drug therapy* / Q000523:psychology; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D008569:Memory Disorders / Q000209:etiology / Q000517:prevention & control* / Q000523:psychology; D008713:Methimazole; D018697:Nootropic Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time; D012116:Resins, Plant / Q000494:pharmacology*; D013550:Swimming; D013997:Time Factors
D018697:Nootropic Agents; D012116:Resins, Plant; D008713:Methimazole