Effect of Xuebijing injection on peripheral T-lymphocyte subpopulations in patients with severe trauma.
OBJECTIVE
To investigate the effect and clinical significance of Xuebijing injection on peripheral T-lymphocyte subpopulations in patients with severe trauma.


METHODS
Thirty-three patients with severe trauma were randomly divided into a control group (n=16) and a treatment group (n=17). The patients of two groups were all treated conventionally, and the only difference was that Xuebijing injection was given to patients of the treatment group. The CD4+ and CD8+ subpopulations of T-lymphocyte in the peripheral blood were detected respectively on admission, 3rd and 5th days after trauma by double antibody labeling and flow cytometry.


RESULTS
The CD4+ T-lymphocytes and CD4+/CD8+ ratio of peripheral blood in patients with severe trauma decreased markedly on the 3rd and 5th days after trauma. Furthermore, compared with control group, the peripheral CD4+ T-lymphocytes and CD4+/CD8+ ratio of treatment group renewed obviously on the 5th day after trauma, and showed statistical differences (P<0.05).


CONCLUSIONS
In the treatment of patients with severe trauma, the early use of Xuebijing injection is effective in correcting disorder or suppression of T-lymphocyte subpopulations regulating network, and promoting a more balanced profile of immunologic function.
Lu
Yuan-qiang
YQ
Department of Emergency, First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. luyuanqiang@yahoo.cn
Gu
Lin-hui
LH
Huang
Wei-dong
WD
D000328:Adult; D016516:CD4-CD8 Ratio; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016176:T-Lymphocyte Subsets / Q000187:drug effects*; D014947:Wounds and Injuries / Q000188:drug therapy* / Q000276:immunology
D004365:Drugs, Chinese Herbal; C549376:Xuebijing