Copper-catalyzed enantioselective 1,4-addition to alpha,beta-unsaturated aldehydes.
The first asymmetric Cu-catalyzed conjugate addition of dialkylzinc zinc reagents to a large scope of enals in presence of phosphoramidite, SimplePhos, or (R)-BINAP ligands with enantiomeric excesses up to 90% is reported. Moreover, ACA of Grignard reagents afforded moderate to good 1,4-regioselectivities with enantioselectivities up to 90%.
Palais
Laëtitia
L
Department of Organic Chemistry, University of Geneva, 30 quai Ernest Ansermet, 1211 Geneve, Switzerland.
Babel
Lucille
L
Quintard
Adrien
A
Belot
Sébastien
S
Alexakis
Alexandre
A