title: Differences in postprandial inflammatory responses to a 'modern' v. traditional meat meal: a preliminary study.
abstract: A low-grade inflammatory response ('metaflammation') has been found to be associated with certain chronic diseases. Proposed inducers of this have been aspects of the modern lifestyle, including newly introduced foods. Plasma TAG, and the inflammatory cytokines C-reactive protein (CRP), TNF-alpha and IL-6 were compared in a randomised, cross-over trial using ten healthy subjects before and after eating 100 g of kangaroo, or a 'new' form of hybridised beef (wagyu) separated by about 1 week. Postprandial levels for 1 and 2 h of TAG, IL-6 and TNF-alpha were significantly higher after eating wagyu compared with kangaroo (P = 0.002 for TAG at 1 h, P < 0.001 at 2 h; P < 0.001 for IL-6 and TNF-alpha at 1 and 2 h). CRP was significantly higher 1 h postprandially after wagyu (P = 0.011) and non-significantly higher 2 h postprandially (P = 0.090). We conclude that the metaflammatory reaction to ingestion of a 'new' form of hybridised beef (wagyu) is indicative of a low-grade, systemic, immune reaction when compared with lean game meat (kangaroo). Further studies using isoenergetic intake and isolating fatty acid components of meats are proposed.
authors.affiliation: School of Human Nutrition, University of Sydney, Sydney, NSW, Australia.
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Arya
authors.forename: Sam
authors.initials: S
authors.lastname: Egger
authors.forename: David
authors.initials: D
authors.lastname: Colquhoun
authors.forename: David
authors.initials: D
authors.lastname: Sullivan
authors.forename: Sebely
authors.initials: S
authors.lastname: Pal
authors.forename: Garry
authors.initials: G
authors.lastname: Egger
mesh_terms: D000328:Adult; D000818:Animals; D002097:C-Reactive Protein / Q000378:metabolism; D002417:Cattle; D018592:Cross-Over Studies; D004032:Diet / Q000009:adverse effects*; D004041:Dietary Fats / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000209:etiology*; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood; D007614:Macropodidae; D008297:Male; D008460:Meat / Q000009:adverse effects*; D019518:Postprandial Period / Q000502:physiology; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood; D055815:Young Adult
chemical_list: D004041:Dietary Fats; D018836:Inflammation Mediators; D015850:Interleukin-6; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein