title: Long-term dietary supplementation with a yang-invigorating Chinese herbal formula increases lifespan and mitigates age-associated declines in mitochondrial antioxidant status and functional ability of various tissues in male and female C57BL/6J mice.
abstract: To investigate whether Vigconic 28 (VI-28), a Yang-invigorating Chinese herbal formula, could affect survival of aging animals, male and female C57BL/6J mice were given a VI-28-supplemented diet (0.05 and 0.5%, wt/wt) starting at 36 weeks of age, until death. VI-28 dietary supplementation at 0.05% significantly increased median lifespans of both male and female mice as compared to controls. Survival enhancement was associated with protection against age-associated impairments in mitochondrial antioxidant status and functional ability in various tissues. In conclusion, VI-28 could retard the aging process in mice, probably by mitigating age-associated declines in mitochondrial antioxidant status and functional ability in tissues.
authors.affiliation: Department of Biochemistry, the Hong Kong University of Science & Technology, Clear Water Bay, Hong Kong SAR, China.
authors.forename: Kam Ming
authors.initials: KM
authors.lastname: Ko
authors.forename: Po Yee
authors.initials: PY
authors.lastname: Chiu
authors.forename: Hoi Yan
authors.initials: HY
authors.lastname: Leung
authors.forename: Ada Hoi Ling
authors.initials: AH
authors.lastname: Siu
authors.forename: Na
authors.initials: N
authors.lastname: Chen
authors.forename: Eriol Pou Kwan
authors.initials: EP
authors.lastname: Leong
authors.forename: Michel K T
authors.initials: MK
authors.lastname: Poon
mesh_terms: D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000821:Animal Feed; D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000502:physiology*; D019587:Dietary Supplements; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D008136:Longevity / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D016019:Survival Analysis; D013997:Time Factors; D016711:Yang Deficiency / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D016709:Yin-Yang
chemical_list: D000975:Antioxidants; D004365:Drugs, Chinese Herbal; C529538:VI-28 herbal formula