title: [Expression of toll-like receptors signaling pathway in chronic rhinosinusitis with nasal polyps].
abstract: OBJECTIVE
  To investigate the expression of Toll-like receptors (TLRs) signaling pathway in chronic rhinosinusitis (CRS) with nasal polyps.
  
  
  METHODS
  Gene microarray analysis was used to detect the expression of TLRs signaling pathway in CRS with nasal polyps.
  
  
  RESULTS
  Of 19 differentially expressed (two fold changes), 4 genes were upregulated and 15 genes were downregulated.
  
  
  CONCLUSIONS
  The differentially expressed genes in TLRs signaling pathway may exert its effect in the pathogenesis of CRS. In addition, the roles of TLR9 and its agonists need further study.
authors.affiliation: Department of Otorhinolaryngology Head and Neck Surgery, Second Hospital Affiliated to Harbin Medical Universitry, Harbin,150086, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Chunyuan
authors.initials: C
authors.lastname: Zhao
authors.forename: Ming
authors.initials: M
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism; D009298:Nasal Polyps / Q000235:genetics / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000235:genetics; D015398:Signal Transduction; D012852:Sinusitis / Q000235:genetics / Q000378:metabolism*; D051193:Toll-Like Receptors / Q000235:genetics / Q000378:metabolism*; D055815:Young Adult
chemical_list: D012333:RNA, Messenger; D051193:Toll-Like Receptors