title: How neuroplasticity and cognitive reserve protect cognitive functioning.
abstract: Overall cognitive status can vary across an individual's life span in response to factors that promote either positive or negative neuroplasticity. Positive neuroplasticity refers to he physiological ability of the brain to form and strengthen dendritic connections, produce beneficial morphological changes, and increase cognitive reserve. Negative neuroplasticity refers to the same physiological ability of t he brain to atrophy and weaken dendritic connections, produce detrimental morphological changes, and decrease cognitive reserve. Factors that promote positive neuroplasticity include physical activity, education, social interaction, intellectual pursuits, and cognitive remediation. Factors that promote negative neuroplasticity include poor health, poor sleep hygiene, poor nutrition, substance abuse, and depression and anxiety. Implications for promoting positive neuroplasticity and avoiding negative neuroplasticity across the life span are emphasized to facilitate optimal cognitive health and ensure successful cognitive aging.
authors.affiliation: School of Nursing, Department of Psychology and Center for Research in Applied Gerontology, University of Alabama at Birmingham, Birmingham, AL 35294-1210, USA. devance@uab.edu
authors.forename: David E
authors.initials: DE
authors.lastname: Vance
authors.forename: Anthony J
authors.initials: AJ
authors.lastname: Roberson
authors.forename: Teena M
authors.initials: TM
authors.lastname: McGuinness
authors.forename: Pariya L
authors.initials: PL
authors.lastname: Fazeli
mesh_terms: D000367:Age Factors; D001008:Anxiety Disorders / Q000451:nursing / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology*; D003072:Cognition Disorders / Q000451:nursing* / Q000503:physiopathology; D058245:Cognitive Reserve / Q000502:physiology*; D003704:Dementia / Q000451:nursing* / Q000503:physiopathology; D003866:Depressive Disorder / Q000451:nursing / Q000503:physiopathology; D004522:Educational Status; D015438:Health Behavior; D006801:Humans; D007398:Interpersonal Relations; D007899:Leisure Activities; D009473:Neuronal Plasticity / Q000502:physiology*; D019966:Substance-Related Disorders / Q000451:nursing / Q000503:physiopathology