Some new biologically active metal-based sulfonamide.
A new series of sulfonamide derived Schiff bases has been synthesized by a condensation reaction of various sulfonamides with aromatic aldehydes. The so obtained sulfonamide were further investigated for their chelation and biological properties with first row d-transition metal ions [cobalt(II), copper(II), nickel(II) and zinc(II)]. The nature of bonding and structure of all the synthesized compounds have been inferred from magnetic susceptibility and conductivity measurements, IR, (1)H and (13)C NMR, electronic spectral, mass spectrometry and CHN analysis data. The structure of ligand, 4-{[(E)-(5-bromo-2-hydroxy phenyl)methylidene]amino}-N-(4,6-dimethylpyrimidin-2-yl)benzenesulfonamide has also been determined by X-ray diffraction method. An octahedral geometry has been suggested for all the complexes. The ligands and their metal complexes have been screened for in vitro antibacterial, antifungal and cytotoxic properties. The result of these studies have revealed that all compounds showed moderate to significant antibacterial activity against one or more bacterial strains and good antifungal activity against various fungal strains.
Chohan
Zahid H
ZH
Department of Chemistry, Bahauddin Zakariya University, Multan-60800, Pakistan. dr.zahidchohan@gmail.com
Shad
Hazoor A
HA
Youssoufi
Moulay H
MH
Ben Hadda
Taibi
T
D000818:Animals; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D001156:Artemia / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D018360:Crystallography, X-Ray; D004553:Electric Conductivity; D005658:Fungi / Q000187:drug effects; D008670:Metals / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D013057:Spectrum Analysis; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity
D000890:Anti-Infective Agents; D008670:Metals; D013449:Sulfonamides