title: Suppressed levels of growth hormone and insulin-like growth factor-1 during successful pregnancy in persistent acromegaly.
abstract: Pregnancy is a rather rare event in acromegaly because fertility is often reduced during active disease. Previous reports of pregnancy in acromegalic patients showed that the pituitary growth hormone (GH) level was unaffected and the insulin-like growth factor (IGF)-1 level was elevated during the second and third trimesters. We describe here a case of persistent acromegaly that showed suppressed levels of GH and IGF-1 during pregnancy. The suppression of GH secretion and IGF-1 may be due to increased estrogen or other factors circulating in mid- to late pregnancy.
authors.affiliation: Clinical Research Institute, National Hospital Organization Kyoto Medical Center, Kyoto, Japan. ashimats@kyotolan.hosp.go.jp
authors.forename: Akira
authors.initials: A
authors.lastname: Shimatsu
authors.forename: Takeshi
authors.initials: T
authors.lastname: Usui
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Tagami
authors.forename: Hideshi
authors.initials: H
authors.lastname: Kuzuya
authors.forename: Jun A
authors.initials: JA
authors.lastname: Takahashi
mesh_terms: D000172:Acromegaly / Q000378:metabolism*; D000328:Adult; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*
chemical_list: D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I