Plasma level of platelet-derived microparticles is associated with coronary heart disease risk score in healthy men.
OBJECTIVE
The aim of this study was to clarify the relationship between platelet-derived microparticles (PDMPs) and the Framingham 10-yr coronary heart disease (CHD) risk score.


METHODS
A cross-sectional study of healthy volunteers free of medication, and cardiovascular or cerebrovascular disease was conducted. The subjects were 190 Japanese men (median age 41). An ELISA kit and monoclonal antibodies against CD42b and CD42a (glycoprotein Ib and IX) were used.


RESULTS
PDMPs are correlated with platelet count, high sensitivity C-reactive protein (hsCRP), and diastolic blood pressure by multivariate analysis (R(2)=0.316, p <0.001). Quartile range of PDMPs is significantly associated with the 10-yr CHD risk score after adjusting for age, platelet count, hsCRP, and hypertension (p=0.033) and for age, platelet count, hsCRP, and presence of metabolic syndrome (MS) (p=0.020). In individuals with a predicted 10-yr risk for CHD >or=8% (corresponding with the highest quartile), compared to those with a predicted 10-yr risk <8%, the odds ratio (OR), adjusted for age, platelet count, hsCRP, and hypertension, was 3.3 (1.2-8.9) and adjusted for age, platelet count, hsCRP, and MS, was 4.5 (1.6-11.8). The age-, platelet count-, hsCRP- and hypertension-adjusted OR for a 10-yr CHD risk score >or=8% was 0.8 (0.5-1.3) for hsCRP and 3.9 (1.6-9.4) for hypertension. The age-, platelet count-, hsCRP- and MS -adjusted OR for a 10-yr CHD risk score >or=8% was 0.7 (0.4-1.2) for hsCRP and 7.9 (2.6-24.5) for MS.


CONCLUSIONS
Elevated PDMPs are associated with the 10-yr CHD risk score in healthy men.
Ueba
Tetsuya
T
Department of Neurosurgery, Kishiwada City Hospital, Osaka, Japan. a.fenton@liverpool.ac.uk
Nomura
Shosaku
S
Inami
Norihito
N
Nishikawa
Tomofumi
T
Kajiwara
Motohiro
M
Iwata
Ryoichi
R
Yamashita
Kohsuke
K
D000328:Adult; D000368:Aged; D001777:Blood Coagulation / Q000502:physiology; D001792:Blood Platelets / Q000378:metabolism*; D002097:C-Reactive Protein / Q000378:metabolism; D055252:Cell-Derived Microparticles; D003327:Coronary Disease / Q000097:blood* / Q000209:etiology; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications; D008875:Middle Aged; D019038:Platelet Glycoprotein GPIb-IX Complex / Q000378:metabolism*; D012307:Risk Factors
D019038:Platelet Glycoprotein GPIb-IX Complex; D002097:C-Reactive Protein