title: Microencephaloceles: another dual pathology of intractable temporal lobe epilepsy in childhood.
abstract: Temporal lobe encephaloceles can be associated with temporal lobe epilepsy. The authors report on the case of an adolescent with multiple microencephaloceles, in the anterolateral middle fossa floor, identified at surgery (temporal lobectomy) for intractable partial-onset seizures of temporal origin. Magnetic resonance imaging revealed only hippocampal atrophy. Subdural electrodes demonstrated ictal activity arising primarily from the anterior and lateral temporal lobe, close to the microencephaloceles, spreading to the anterior and posterior mesial structures. Pathological examination revealed diffuse temporal gliosis involving the hippocampus, together with microdysgenesis of the amygdala. The literature on epilepsy secondary to encephaloceles is reviewed and the contribution of the microencephaloceles to the seizure disorder in this patient is discussed.
authors.affiliation: Department of Neurosurgery, Frenchay Hospital, Bristol, United Kingdom.
authors.forename: Kristian
authors.initials: K
authors.lastname: Aquilina
authors.forename: Dave F
authors.initials: DF
authors.lastname: Clarke
authors.forename: James W
authors.initials: JW
authors.lastname: Wheless
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Boop
mesh_terms: D000293:Adolescent; D000679:Amygdala / Q000473:pathology / Q000601:surgery; D035301:Cranial Fossa, Middle / Q000473:pathology / Q000601:surgery; D004569:Electroencephalography; D004677:Encephalocele / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D004833:Epilepsy, Temporal Lobe / Q000209:etiology* / Q000473:pathology* / Q000601:surgery; D005260:Female; D005911:Gliosis / Q000473:pathology / Q000601:surgery; D006624:Hippocampus / Q000473:pathology / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D008588:Meningocele / Q000150:complications* / Q000473:pathology* / Q000601:surgery; D013702:Temporal Lobe / Q000473:pathology / Q000601:surgery