Change in lifestyle behaviors and medication use after a diagnosis of ductal carcinoma in situ.
Women with ductal carcinoma in situ (DCIS) of the breast represent a growing cancer survivor population with a diagnosis of uncertain malignant potential. These survivors face an absence of scientific guidelines regarding lifestyle changes that can help to prevent a breast cancer recurrence. In this first report from the Wisconsin In Situ Cohort (WISC) study, we examine how women are currently changing their lifestyle behaviors and medication use following a diagnosis of DCIS. At study entry (1997-2006), 1,959 subjects (78% of eligible) with DCIS were identified from the Wisconsin cancer registry and administered an interview assessing behaviors prior to diagnosis. Follow-up interviews were completed every 2 years after the initial interview, beginning in 2003 and continuing through 2006. After adjusting for age and calendar year, women were 2.2 kg (95% CI 1.4, 3.0) heavier, 35% (95% CI 20, 47) less likely to be a smoker, 19% (95% CI -1, 43) more likely to use non-steroidal anti-inflammatory drugs, and 57% (95% CI 26, 95) more likely to use antidepressants after a DCIS diagnosis compared to 1 year prior to diagnosis. Use of postmenopausal hormones decreased sharply (OR = 0.06; 95% CI 0.04, 0.09) following a DCIS diagnosis. These findings indicate that women make substantial changes in their behaviors after a DCIS diagnosis. This cohort will be further monitored to evaluate the association between these behaviors and health outcomes following DCIS.
Sprague
Brian L
BL
Department of Population Health Sciences, University of Wisconsin-Madison, Madison, WI 53726, USA. bsprague@wisc.edu
Trentham-Dietz
Amy
A
Nichols
Hazel B
HB
Hampton
John M
JM
Newcomb
Polly A
PA
D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000523:psychology* / Q000628:therapy; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis / Q000401:mortality / Q000473:pathology / Q000523:psychology* / Q000628:therapy; D015331:Cohort Studies; D004032:Diet; D015914:Estrogen Replacement Therapy; D005260:Female; D015438:Health Behavior; D007722:Health Knowledge, Attitudes, Practice; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D016017:Odds Ratio; D011788:Quality of Life; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D040242:Risk Reduction Behavior; D016540:Smoking Cessation; D017741:Survivors / Q000523:psychology*; D013997:Time Factors; D016896:Treatment Outcome; D015430:Weight Gain; D014922:Wisconsin; D055815:Young Adult
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000928:Antidepressive Agents