title: Toxicokinetics of a dipyridamole (Persantin) intoxication: case report.
abstract: We report a case of a 51-year-old woman who was admitted to the hospital after ingestion of large doses of dipyridamole (12 g), temazepam (1 g) and oxazepam (0.2 g) with suicidal intent. The highest dipyridamole concentration that was measured in serum was 9.2 mg/L, which was paralleled by impaired platelet activation. For temazepam and oxazepam, peak serum concentrations were 8.5 and 1.3 mg/L, respectively. The patient was treated with activated charcoal, magnesium sulfate and aminophylline and could be discharged in good physical condition within 17 hours. This is the first report that provides toxicokinetic data and a corresponding pharmacodynamic effect after an intoxication with dipyridamole.
authors.affiliation: Department of Pharmacy & Pharmacology, Slotervaart Hospital, Louwesweg 6, Amsterdam, The Netherlands. jurjen.lagas@slz.nl
authors.forename: Jurjen S
authors.initials: JS
authors.lastname: Lagas
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Wilhelm
authors.forename: René M
authors.initials: RM
authors.lastname: Vos
authors.forename: Erik-Jan
authors.initials: EJ
authors.lastname: van den Dool
authors.forename: Yvonne
authors.initials: Y
authors.lastname: van der Heide
authors.forename: Sandra
authors.initials: S
authors.lastname: Huissoon
authors.forename: Jos H
authors.initials: JH
authors.lastname: Beijnen
authors.forename: Desiderius P M
authors.initials: DP
authors.lastname: Brandjes
mesh_terms: D014151:Anti-Anxiety Agents / Q000506:poisoning; D004176:Dipyridamole / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010076:Oxazepam / Q000506:poisoning; D010975:Platelet Aggregation Inhibitors / Q000097:blood / Q000493:pharmacokinetics* / Q000506:poisoning*; D013406:Suicide, Attempted; D013693:Temazepam / Q000506:poisoning
chemical_list: D014151:Anti-Anxiety Agents; D010975:Platelet Aggregation Inhibitors; D004176:Dipyridamole; D010076:Oxazepam; D013693:Temazepam