title: Treatment of Wilms tumor: a report from the Turkish Pediatric Oncology Group (TPOG).
abstract: OBJECTIVE
  To standardize diagnosis and treatment of childhood Wilms tumor (WT) in Turkey.
  
  
  METHODS
  Between 1998 and 2006, WT patients were registered from 19 centers. Patients <16 years with unilateral WT whose treatment started in first postoperative 3 weeks were included. Treatments were stage I favorable (FH) and unfavorable histology (UH) patients, VCR + Act-D; stage IIA FH, VCR + Act-D; stage IIB FH, VCR + Act-D + radiotherapy (RT); stage III-IV FH, VCR + Act-D + adriamycin (ADR) + RT; stages II-IV UH tumors, VCR + Act-D + ADR + etoposide + RT.
  
  
  RESULTS
  165/254 registered cases were eligible (bilateral, 5.9%) [median age 3.0 years; M/F: 0.99; 50/165 cases < or =2 years]. 9.7% cases had UH tumors. Disease stages were stage I 23.6%; IIA 36.4%; IIB 5.5%; III 22.4%; IV 12.1%. Cases >2 years had significantly more advanced disease. 1/11 cases with recurrent disease died; 2/165 had progressive disease, 2/165 had secondary cancers, and all 4 died. In all cases 4-year OS and EFS were 92.8 and 86.5%, respectively. Both OS and EFS were significantly worse in stage IV.
  
  
  CONCLUSIONS
  Despite problems in patient management and follow-up, treatment results were encouraging in this first national experience with a multicentric study in pediatric oncology. Revisions and modifications are planned to further improve results and minimize short- and long-term side effects.
authors.affiliation: Hacettepe University Faculty of Medicine, Dept. of Pediatric Oncology, Ankara, Turkey. cakyuz@hacettepe.edu.tr
authors.forename: Canan
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authors.lastname: Akyüz
authors.forename: Bilgehan
authors.initials: B
authors.lastname: Yalçin
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authors.lastname: Yildiz
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authors.forename: Asim
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authors.lastname: Yörük
authors.forename: Gülnur
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authors.lastname: Tokuç
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authors.forename: Nebil
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authors.lastname: Büyükpamukçu
authors.forename: Gülsev
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authors.lastname: Atahan
authors.forename: Cenk
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authors.lastname: Büyükünal
authors.forename: Sergülen
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authors.lastname: Dervişoğlu
authors.forename: Gülyüz Akyil
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authors.lastname: Atkovar
authors.forename: Mustafa
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authors.lastname: Melikoğlu
authors.forename: Gülten
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authors.lastname: Karpuzoğlu
authors.forename: Nur
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authors.forename: Inci
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authors.forename: Aynur
authors.initials: A
authors.lastname: Oğuz
authors.forename: Nilgün
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authors.lastname: Yariş
authors.forename: Ayhan
authors.initials: A
authors.lastname: Dağdemir
authors.forename: Emin
authors.initials: E
authors.lastname: Darendeliler
authors.forename: Serdar
authors.initials: S
authors.lastname: Sander
authors.forename: Uğur
authors.initials: U
authors.lastname: Kuyumcuoğlu
authors.forename: Naciye
authors.initials: N
authors.lastname: Ozşeker
authors.forename: Funda
authors.initials: F
authors.lastname: Corapçioğlu
authors.forename: Atilla
authors.initials: A
authors.lastname: Tanyeli
authors.forename: Oznur
authors.initials: O
authors.lastname: Düzovali
authors.forename: G Burça
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authors.lastname: Aydin
authors.forename: Münevver
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authors.lastname: Büyükpamukçu
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007680:Kidney Neoplasms / Q000401:mortality / Q000628:therapy*; D008297:Male; D009396:Wilms Tumor / Q000401:mortality / Q000628:therapy*