Chemoselective coupling reactions of 5,7-dimethoxyphthalide with the remotely functionalized alkyl iodides: facile racemic synthesis of Helicobacter pylori antibiotics.
Highly chemoselective coupling reactions of 5,7-dimethoxyphthalide carbanion with the remotely functionalized long chain alkyl iodides have been demonstrated to accomplish the concise and efficient synthesis of Helicobacter pylori antibiotics, the CJ-molecules, and sporotricale methyl ether.
Singh
Mandeep
M
Division of Organic Chemistry, National Chemical Laboratory (CSIR), Pune 411 008, India.
Argade
Narshinha P
NP
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry*; D003500:Cyclization; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry*; D015394:Molecular Structure; D013141:Spiro Compounds / Q000138:chemical synthesis; D013237:Stereoisomerism
C551130:5,7-dimethoxyphthalide; D000900:Anti-Bacterial Agents; D001572:Benzofurans; D006847:Hydrocarbons, Iodinated; D013141:Spiro Compounds