MicroRNA-regulated protein-protein interaction networks: how could they help in searching for pro-longevity targets?
In spite of enormous efforts and accumulated knowledge, our capabilities for tackling aging and age-related diseases (ARDs), and ultimately to promote longevity, are still very modest. What is lacking--essential data on key players, efficient analytic tools, or both? Here we discuss how the existing data may be integrated and analyzed in the context of microRNA (miRNA)-regulated protein-protein interaction networks. The proposed model highlighted: (1) The strong molecular links between aging, longevity, and ARDs; (2) the possibility and even the preferability of initiating longevity-promoting interventions in adult life; (3) the potentially important role for miRNA- (or small interfering RNA [siRNA]) mediated targeting of certain genes with features of antagonistic pleiotropy; (4) the superiority of systemic interventions to the common single-target approach in curing ARDs and promoting longevity.
Tacutu
Robi
R
The Shraga Segal Department of Microbiology and Immunology, Center for Multidisciplinary Research on Aging, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Budovsky
Arie
A
Wolfson
Marina
M
Fraifeld
Vadim E
VE
D000328:Adult; D000818:Animals; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks / Q000502:physiology; D056726:Genetic Association Studies / Q000379:methods; D006801:Humans; D008136:Longevity / Q000235:genetics*; D051379:Mice; D035683:MicroRNAs / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis; D011485:Protein Binding / Q000187:drug effects; D025941:Protein Interaction Mapping; D011506:Proteins / Q000378:metabolism*; D054928:Validation Studies as Topic
D035683:MicroRNAs; D011506:Proteins