title: Elafin is a biomarker of graft-versus-host disease of the skin.
abstract: Graft-versus-host disease (GVHD), the major complication of allogeneic bone marrow transplantation, affects the skin, liver, and gastrointestinal tract. There are no plasma biomarkers specific for any acute GVHD target organ. We used a large-scale quantitative proteomic discovery procedure to identify biomarker candidates of skin GVHD and validated the lead candidate, elafin, with enzyme-linked immunosorbent assay in samples from 492 patients. Elafin was overexpressed in GVHD skin biopsies. Plasma concentrations of elafin were significantly higher at the onset of skin GVHD, correlated with the eventual maximum grade of GVHD, and were associated with a greater risk of death relative to other known risk factors (hazard ratio, 1.78). We conclude that elafin has significant diagnostic and prognostic value as a biomarker of skin GVHD.
authors.affiliation: Department of Pediatrics, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Sophie
authors.initials: S
authors.lastname: Paczesny
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Braun
authors.forename: John E
authors.initials: JE
authors.lastname: Levine
authors.forename: Jason
authors.initials: J
authors.lastname: Hogan
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Crawford
authors.forename: Bryan
authors.initials: B
authors.lastname: Coffing
authors.forename: Stephen
authors.initials: S
authors.lastname: Olsen
authors.forename: Sung W
authors.initials: SW
authors.lastname: Choi
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Vitor
authors.initials: V
authors.lastname: Faca
authors.forename: Sharon
authors.initials: S
authors.lastname: Pitteri
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Alice
authors.initials: A
authors.lastname: Chin
authors.forename: Carrie
authors.initials: C
authors.lastname: Kitko
authors.forename: Shin
authors.initials: S
authors.lastname: Mineishi
authors.forename: Gregory
authors.initials: G
authors.lastname: Yanik
authors.forename: Edward
authors.initials: E
authors.lastname: Peres
authors.forename: David
authors.initials: D
authors.lastname: Hanauer
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Pavan
authors.initials: P
authors.lastname: Reddy
authors.forename: Samir
authors.initials: S
authors.lastname: Hanash
authors.forename: James L M
authors.initials: JL
authors.lastname: Ferrara
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D053492:Elafin / Q000096:biosynthesis*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008875:Middle Aged; D011379:Prognosis; D012867:Skin / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D053492:Elafin