Bending affects entropy of semiflexible polymers: Application to protein-DNA complexes.
We discuss a class of generalized wormlike chain models of polymers with spontaneous curvature and show that the density of states and consequently the entropy of such natively bent polymers are higher than that of straight ones. This effect changes the classical Langmuir binding isotherm by giving rise to enhanced binding of DNA-bending proteins.
Rappaport
Shay M
SM
Department of Physics and Institute of Nanotechnology and Advanced Materials, Bar-Ilan University, Ramat-Gan 52900, Israel.
Rabin
Yitzhak
Y
D001665:Binding Sites; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry* / Q000648:ultrastructure*; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000648:ultrastructure*; D055119:Elastic Modulus; D019277:Entropy; D008956:Models, Chemical; D008958:Models, Molecular; D011108:Polymers / Q000737:chemistry; D011485:Protein Binding; D013816:Thermodynamics
D004268:DNA-Binding Proteins; D011108:Polymers; D004247:DNA