On-resin peptide macrocyclization using thiol-ene click chemistry.
A versatile and rapid synthetic strategy has been developed for the on-resin cyclization of peptides using thiol-ene photochemistry. This unique method exploits the thiol group of natural cysteine amino acids and allows for various alkenes to be incorporated orthogonal to the peptide backbone.
Aimetti
Alex A
AA
Department of Chemical & Biological Engineering, University of Colorado, Boulder, CO 80309, USA.
Shoemaker
Richard K
RK
Lin
Chien-Chi
CC
Anseth
Kristi S
KS
D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D003500:Cyclization; D003545:Cysteine / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D010777:Photochemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry*
D010456:Peptides, Cyclic; D013438:Sulfhydryl Compounds; D003545:Cysteine