title: Multicentric reticulohistiocytosis with S100 protein positive staining: a case report.
abstract: Multicentric reticulohistiocytosis is a very rare systemic disease that affects skin, mucosa and joints. We reported a case of a woman with multicentric reticulohistiocytosis who presented typical skin syndromes and arthralgia. Immunohistochemical analysis showed positive staining for S100 protein, which was reported negative in the majority of previously presented cases. Other immunohistochemical markers (CD68(+), CD1a(-), lagerin (-) and complete histologic and clinical picture were specific enough to make the definitive diagnosis of multicentric reticulohistiocytosis. The patient was administered prednisone just when arthritis appeared and we believe that this therapy protected her from the development of destructive arthritis. No autoimmune disease or internal malignancy was observed during 12-month follow up.
authors.affiliation: Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, Chalubinskiego 1, 50-368 Wroclaw, Poland. rafalb@derm.am.wroc.pl
authors.forename: Rafal
authors.initials: R
authors.lastname: Bialynicki-Birula
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Sebastian-Rusin
authors.forename: Joanna
authors.initials: J
authors.lastname: Maj
authors.forename: Zdzislaw
authors.initials: Z
authors.lastname: Wozniak
authors.forename: Eugeniusz
authors.initials: E
authors.lastname: Baran
authors.forename: Piotr
authors.initials: P
authors.lastname: Dziegiel
mesh_terms: D000328:Adult; D001706:Biopsy; D003937:Diagnosis, Differential; D005148:Facial Dermatoses / Q000175:diagnosis*; D005260:Female; D006229:Hand Dermatoses / Q000175:diagnosis*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000175:diagnosis* / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D009418:S100 Proteins / Q000276:immunology*
chemical_list: D009418:S100 Proteins; C110294:S100A1 protein