Combined solid/solution phase synthesis of large surface area scaffolds derived from aminomethyl-benzoates.
A set of macrocycles was generated by solid phase synthesis of linear trimers of 5-aminoacyl-3-aminomethyl-benzoates followed by resin cleavage and solution phase macrocyclization. These scaffolds can serve as useful building blocks for molecular recognition studies, especially where differentially functionalized molecular platforms spanning large surface areas are required.
Jain
Rishi K
RK
Department of Chemistry, Yale University, New Haven, CT 06520, U.S.A.
Tsou
Lun K
LK
Hamilton
Andrew D
AD