The updated view concerning the possibility of growing old without senescence.
New findings paradoxically highlight the capability of old mitochondria, precursor cells, tissues, and organs for rejuvenation during vital activity at appropriate conditions and modes. But most studies of aging are conducted in living beings situated in rather artificial conditions. Such external conditions are less adequate to the evolutionarily adjusted genetic construction of an organism and lead to the appearance of senescence due to incomplete self-maintenance processes. These arguments as well as other findings suggest that imitation of appropriate external signals or peculiar modification of control systems of an organism can lead to the state of full nonsenescence.
Khalyavkin
Alexander V
AV
Institute of Biochemical Physics of RAS, Moscow, Russia and Institute for Systems Analysis of RAS, Moscow, Russia. ab3711@mail.sitek.net
D000375:Aging / Q000473:pathology* / Q000502:physiology*; D000818:Animals; D005075:Biological Evolution; D016922:Cellular Senescence / Q000502:physiology; D004777:Environment; D006801:Humans; D012060:Rejuvenation / Q000502:physiology