title: New flavonoids with 2BS cell proliferation promoting effect from the seeds of Trigonella foenum-graecum L.
abstract: Ten flavonoids were isolated from the ethyl acetate-soluble fraction of the ethanolic extract of the seeds of Trigonella foenum-graecum and their structures were elucidated on the basis of spectroscopic methods to be 5,7,3'-trihydroxy-5'-methoxylisoflavone (1), biochanin A (2), formononetin (3), irilone (4), tricin (5), daidzein (6), calycosin (7), orientin-2''-O-p-trans-coumarate (8), vitexin-2''-O-p-trans-coumarate (9), and tricin-7-O-beta-D: -glucopyranoside (10). Compounds 1 and 8 are new flavonoids, and 8 and 9 strongly promoted 2BS cell proliferation induced by H(2)O(2).
authors.affiliation: Institute of Materia Medica, Shandong Academy of Medical Sciences, Jinan 250062, China.
authors.forename: Guo-Rong
authors.initials: GR
authors.lastname: Wang
authors.forename: Wen-Zhao
authors.initials: WZ
authors.lastname: Tang
authors.forename: Qing-Qiang
authors.initials: QQ
authors.lastname: Yao
authors.forename: Hao
authors.initials: H
authors.lastname: Zhong
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Liu
mesh_terms: D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects*; D003373:Coumaric Acids / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry* / Q000494:pharmacology*; D019833:Genistein / Q000737:chemistry; D005960:Glucosides / Q000737:chemistry; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007529:Isoflavones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry*; D029910:Trigonella / Q000737:chemistry*
chemical_list: D003373:Coumaric Acids; D005419:Flavonoids; D005960:Glucosides; D007529:Isoflavones; D010936:Plant Extracts; C530234:irilone; C121707:7,3'-dihydroxy-4'-methoxyisoflavone; C007768:formononetin; D006861:Hydrogen Peroxide; C017769:tricin; D019833:Genistein; C004541:biochanin A