[Comparison of breast cancer in young and old women based on clinicopathological features].
The two far ends of the age at the diagnosis of breast cancer are the age of younger than 35, and that of older than 70. Most probably, these two groups of patients differ in many ways. The aim of our present study was to underline the fact that age at the diagnosis of breast cancer is indeed a prognostic factor. Between October 1995 and March 2009, 80 old and 51 young breast cancer patients were treated at the Department of Diagnostic Radiology and Oncotherapy, Semmelweis University, Budapest. The prognostic and predictive factors of the tumors were analysed together with the disease-free and overall survival data. There were statistically significant differences between the two groups concerning the menstrual and reproductive factors, histological characteristics and immunophenotype of the tumors. Tumor size, nodal status and the Nottingham Prognostic Index did not show statistically significant differences. A trend to a shorter disease-free survival, higher rate of distant metastases and disease-specific death was seen in the group of young patients, but it was not significant. Overall survival was significantly shorter in the group of young patients. Therefore, we can state that young patients have a more aggressive disease and worse outcome. There is an increased importance of self examination in these groups, since both age groups are beyond the age limits of the screening population in Hungary. The media and primary school education as well should be involved in educating women concerning this aspect. The individual follow-up of young patients with positive family history should also be established.
Székely
Borbála
B
Semmelweis Egyetem, AOK, Radiológiai és Onkoterápiás Klinika, 1082 Budapest, Ulloi út 78/a. szekely@radi.sote.hu
Madaras
Lilla
L
Szentmártoni
Gyöngyvér
G
Szász
A Marcell
AM
Baranyák
Zsuzsanna
Z
Szittya
Liliána
L
Torgyík
László
L
Zergényi
Eva
E
Borbényi
Erika
E
Kenessey
István
I
Korompay
Anna
A
Langmár
Zoltán
Z
Bánhidy
Ferenc
F
Kulka
Janina
J
Dank
Magdolna
M
D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D019398:Genes, BRCA1; D024522:Genes, BRCA2; D016147:Genes, Tumor Suppressor; D006801:Humans; D006814:Hungary / Q000453:epidemiology; D008207:Lymphatic Metastasis; D009154:Mutation; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D012098:Reproduction; D012307:Risk Factors
D014408:Biomarkers, Tumor; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C508053:ERBB2 protein, human