Effects of exercise training on resting energy expenditure and lean mass during pediatric burn rehabilitation.
Severe burns cause profound hormonal and metabolic disturbances resulting in hypermetabolism, reflected in extreme elevation of resting energy expenditure (REE) and extensive skeletal muscle catabolism. Aerobic and resistive exercise programs during rehabilitation have shown substantial benefits, although whether such training potentially exacerbates basal metabolism is unknown. Therefore, the effects of exercise training on REE during the rehabilitation of severely burned pediatric patients were examined. Children with 40% total body surface area burns and greater were enrolled at admission to the burn intensive care unit to participate in a 12-week, hospital-based exercise program (EX) or a home-based standard of care program (SOC), commencing 6 months after injury. Twenty-one patients (aged 7-17 years) were enrolled and randomized to SOC (n = 10) or EX (n = 11). Age, sex, and total body surface area burned were similar. Mean change (+/-standard deviation) in REE, normalized to individual lean body mass, was almost negligible between SOC and EX group patients (SOC, 0.03 +/- 17.40% vs EX, 0.01 +/- 26.38%). A significant increase in lean body mass was found for EX patients (SOC, 2.06 +/- 3.17% vs EX, 8.75 +/- 5.65%; P = .004), which persisted when normalized to height (SOC, 0.70 +/- 2.39% vs EX, 6.14 +/- 6.46%; P = .02). Peak torque also improved significantly more in EX patients (SOC, 12.29 +/- 16.49% vs EX, 54.31 +/- 44.25%; P = .02), reflecting improved strength. Exercise training significantly enhanced lean mass and strength, without observed exacerbation of postburn hypermetabolism. Therefore, the use of exercise conditioning as a safe and effective component of pediatric burn rehabilitation is advocated.
Al-Mousawi
Ahmed M
AM
Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, USA.
Williams
Felicia N
FN
Mlcak
Ronald P
RP
Jeschke
Marc G
MG
Herndon
David N
DN
Suman
Oscar E
OE
D015502:Absorptiometry, Photon; D000293:Adolescent; D001481:Basal Metabolism; D002053:Burn Units; D002056:Burns / Q000534:rehabilitation*; D002648:Child; D004734:Energy Metabolism; D015444:Exercise; D005080:Exercise Test; D005081:Exercise Therapy; D005260:Female; D006339:Heart Rate; D006699:Home Care Services; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D009119:Muscle Contraction; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000378:metabolism*; D010101:Oxygen Consumption; D010372:Pediatrics; D015397:Program Evaluation; D055070:Resistance Training; D012146:Rest; D019415:Torque