Systematic review and meta-analysis of the association between P53 codon 72 polymorphism and colorectal cancer.
BACKGROUND
A number of studies has evaluated the association between P53 codon 72 polymorphism and colorectal cancer. However, results were inconsistent. To clarify the role of this polymorphism in colorectal cancer, we conducted a meta-analysis on this topic.


METHODS
Two authors independently searched the PubMed and EMBASE database from 1966 to January 2010 for studies regarding the association of P53 codon 72 polymorphism with colorectal cancer. Summary odds ratios with their corresponding 95% confidence intervals were calculated by using random-effects model.


RESULTS
The combined results showed that P53 codon 72 variant genotypes were not associated with colorectal cancer risk when compared to Arg/Arg genotype (Pro/Pro: OR = 1.02, 95% CI = 0.80-1.29; Arg/Pro: OR = 1.00, 95% CI = 0.86-1.16; Pro allele: OR = 1.00, 95% CI = 0.86-1.17). When stratifying for study population, design and cancer location, no statistically significant results were observed either.


CONCLUSIONS
Our data indicate that the P53 codon 72 polymorphism may be not associated with colorectal cancer risk.
Tang
N-P
NP
National Shanghai Center for New Drug Safety Evaluation and Research, Shanghai institute of pharmaceutical industry, 199 Guoshoujing Road, Zhangjiang Hi-Tech Park, Pudong, Shanghai 201203, PR China. naping.tang@gmail.com
Wu
Y-M
YM
Wang
B
B
Ma
J
J
D003062:Codon; D015179:Colorectal Neoplasms / Q000235:genetics*; D005787:Gene Frequency; D016158:Genes, p53 / Q000235:genetics*; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic; D012307:Risk Factors
D003062:Codon