Computational genetic mapping in mice: the ship has sailed.
Computational haplotype-based genetic mapping can be used to discover new biological mechanisms, disease-related pathways, and unexpected uses for existing drugs. Here we discuss the benefits and limitations of this methodology, its impact on translational medicine, and its future course.
Zheng
Ming
M
Department of Anesthesia, Stanford University, Stanford, CA, USA.
Shafer
Steve
S
Liao
Guochun
G
Liu
Hong-Hsing
HH
Peltz
Gary
G
D000818:Animals; D051379:Mice / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci; D011995:Recombination, Genetic