title: [Depression and cardiovascular disease--is there an association?].
abstract: BACKGROUND
  Depression is associated with an increased risk of cardiovascular events. This review presents data from recent cohort- and interventional studies, and possible pathogenetic mechanisms.
  
  
  METHODS
  The article is based on literature from the period 1998 - 2008 identified through a non-systematic search in Medline.
  
  
  RESULTS
  Epidemiological studies of patients (outside of hospitals) with clinical depression suggest they have an increased risk of cardiovascular events. Possible mechanisms responsible for this increased cardiovascular risk are: an increased prevalence of unhealthy lifestyle factors, systemic inflammation, endocrine or autonomic dysfunction, increased platelet reactivity or endothelial dysfunction. Treatment with antidepressive drugs has not reduced the risk of cardiovascular events.
  
  
  CONCLUSIONS
  Clinicians should be aware of the influence of depression on cardiovascular risk.
authors.affiliation: Medisinsk divisjon, Akershus universitetssykehus, 1478 Lørenskog, og Institutt for sykehusmedisin, Universitetet i Oslo, Norway. geinvik@online.no
authors.forename: Gunnar
authors.initials: G
authors.lastname: Einvik
authors.forename: Toril
authors.initials: T
authors.lastname: Dammen
authors.forename: Torbjørn
authors.initials: T
authors.lastname: Omland
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use; D050197:Atherosclerosis / Q000209:etiology; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000523:psychology; D003863:Depression / Q000150:complications* / Q000188:drug therapy; D003866:Depressive Disorder / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008019:Life Style; D011602:Psychophysiologic Disorders / Q000209:etiology*; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents