NF-kappaB fans the flames of lung carcinogenesis.
This perspective on Deng et al. (beginning on p. 424 in this issue of the journal) examines the link between NF-kappaB and lung tumorigenesis. Experiments in genetically engineered mouse models of lung cancers are elucidating protumorigenic roles of NF-kappaB activation in lung cancer pathogenesis. Our growing understanding of the tumor-promoting NF-kappaB downstream effector pathways could lead to the development of novel approaches for lung cancer therapy and chemoprevention.
Wong
Kwok-Kin
KK
Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA. Kwong1@partners.org
Jacks
Tyler
T
Dranoff
Glenn
G
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D008175:Lung Neoplasms / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D016328:NF-kappa B / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D016328:NF-kappa B