[Comparative efficiency of indapamide combinations with various derivaties of calcium antagonists in patients with arterial hypertension].
The study included 59 patients aged 42-65 yr with grade II AH. They underwent 24 hour AP monitoring and Doppler echocardiography before and 16 weeks after onset of the study. The patients were randomly allocated to 2 groups. In group 1, they were given combined therapy with indapamide and verapamil retard. Patients of group 2 were treated with indapamide and amlodipine. AP circadian rhythm returned to normal in 83 and 78.6% of the patients in groups 1 and 2 respectively. Combined therapy in group 1 was especially beneficial for patients with type 1 left ventricular diastolic dysfunction, daily non-dipper profile, and hyperkinetic type of blood circulation. In group 2, the most pronounced changes were documented in patients with type II-III left ventricular diastolic dysfunction and hypokinetic type of circulation.
Iskenderov
B G
BG
Sisina
O N
ON
Gridneva
E V
EV
Lokhina
T V
TV
D000328:Adult; D000368:Aged; D017311:Amlodipine / Q000008:administration & dosage / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D007190:Indapamide / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D016277:Ventricular Function, Left / Q000187:drug effects / Q000502:physiology; D014700:Verapamil / Q000008:administration & dosage / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D017311:Amlodipine; D014700:Verapamil; D007190:Indapamide