title: Maintenance of physical activity and body weight in relation to subsequent quality of life in postmenopausal breast cancer patients.
abstract: BACKGROUND
  We prospectively examined the association between physical activity, body weight and quality of life in Dutch postmenopausal early breast cancer patients treated with adjuvant endocrine therapy.
  
  
  METHODS
  In this side study of a large clinical trial, lifestyle and quality-of-life questionnaires were filled out 1 and 2 years after the start of endocrine therapy (T1 and T2, respectively) and included a pre-diagnosis lifestyle assessment (T0). A total of 435 breast cancer patients returned both questionnaires.
  
  
  RESULTS
  Individuals with a physical activity level above the median who maintained this level from T0 to T1 reported the best global quality of life and physical functioning and the least fatigue at T2, as compared with individuals with low levels of physical activity which further decreased after diagnosis (difference of +16, +14, and -22 points on a 0-100 quality-of-life scale, respectively; P < 0.01). Overweight or obese women who gained body weight after diagnosis reported worst quality of life and most fatigue as compared with women who maintained a stable body weight (difference of -8, -10 and +2 points, respectively; P < 0.01).
  
  
  CONCLUSIONS
  Maintaining high pre-diagnosis physical activity levels and a healthy body weight is associated with better quality of life after breast cancer.
authors.affiliation: Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam. Electronic address: d.w.voskuil@hhs.nl.
authors.forename: D W
authors.initials: DW
authors.lastname: Voskuil
authors.affiliation: Department of Surgery, Leiden University Medical Centre, Leiden.
authors.forename: J G H
authors.initials: JGH
authors.lastname: van Nes
authors.affiliation: Department of Surgery, Leiden University Medical Centre, Leiden.
authors.forename: J M C
authors.initials: JMC
authors.lastname: Junggeburt
authors.affiliation: Department of Surgery, Leiden University Medical Centre, Leiden.
authors.forename: C J H
authors.initials: CJH
authors.lastname: van de Velde
authors.affiliation: Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam.
authors.forename: F E
authors.initials: FE
authors.lastname: van Leeuwen
authors.affiliation: Department of Medical Psychology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: J C J M
authors.initials: JCJM
authors.lastname: de Haes
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D001835:Body Weight; D001943:Breast Neoplasms / Q000503:physiopathology* / Q000628:therapy; D015444:Exercise / Q000502:physiology*; D005221:Fatigue; D005260:Female; D006801:Humans; D007390:International Agencies; D008019:Life Style; D008875:Middle Aged; D009367:Neoplasm Staging; D050177:Overweight; D017698:Postmenopause; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D012307:Risk Factors; D015996:Survival Rate