Whole-genome characterization and genotyping of global WU polyomavirus strains.
Exploration of the genetic diversity of WU polyomavirus (WUV) has been limited in terms of the specimen numbers and particularly the sizes of the genomic fragments analyzed. Using whole-genome sequencing of 48 WUV strains collected in four continents over a 5-year period and 16 publicly available whole-genome sequences, we identified three main WUV clades and five subtypes, provisionally termed Ia, Ib, Ic, II, IIIa, and IIIb. Overall nucleotide variation was low (0 to 1.2%). The discriminatory power of the previous VP2 fragment typing method was found to be limited, and a new, larger genotyping region within the VP2/1 interface was proposed.
Bialasiewicz
Seweryn
S
Sir Albert Sakzewski Virus Research Centre, Building C28, Back Rd., Herston, Queensland 4029, Australia. seweryn@uq.edu.au
Rockett
Rebecca
R
Whiley
David W
DW
Abed
Yacine
Y
Allander
Tobias
T
Binks
Michael
M
Boivin
Guy
G
Cheng
Allen C
AC
Chung
Ju-Young
JY
Ferguson
Patricia E
PE
Gilroy
Nicole M
NM
Leach
Amanda J
AJ
Lindau
Cecilia
C
Rossen
John W
JW
Sorrell
Tania C
TC
Nissen
Michael D
MD
Sloots
Theo P
TP
D001483:Base Sequence; D014644:Genetic Variation; D016679:Genome, Viral; D006801:Humans; D008969:Molecular Sequence Data; D010802:Phylogeny; D011120:Polyomavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D027601:Polyomavirus Infections / Q000821:virology*