New tools for detecting occult monoclonal gammopathy, a cause of secondary osteoporosis.
Most patients with multiple myeloma or other monoclonal gammopathies present with anemia, hypercalcemia, or renal insufficiency. However, osteoporosis may be the first sign. Measuring the concentration and ratio of free light chains in the serum can help detect monoclonal gammopathy and help to differentiate myeloma-related bone loss from other secondary forms of osteoporosis.
Faiman
Beth
B
Taussig Cancer Institute, R33, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. faimanb@ccf.org
Licata
Angelo A
AA
D015502:Absorptiometry, Photon; D000369:Aged, 80 and over; D001416:Back Pain / Q000175:diagnosis* / Q000209:etiology*; D015519:Bone Density; D001862:Bone Resorption; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000150:complications* / Q000175:diagnosis*; D009101:Multiple Myeloma / Q000175:diagnosis*; D010024:Osteoporosis / Q000175:diagnosis* / Q000209:etiology*; D016103:Spinal Fractures / Q000175:diagnosis* / Q000209:etiology*