title: Vaginal birth after caesarean for women with three or more prior caesareans: assessing safety and success.
abstract: OBJECTIVE
  To estimate the rate of success and risk of maternal morbidities in women with three or more prior caesareans who attempt vaginal birth after caesarean (VBAC).
  
  
  METHODS
  Retrospective cohort design.
  
  
  METHODS
  Multicentre, from 1996 to 2000, including 17 tertiary and community delivery centres in north-eastern USA.
  
  
  METHODS
  A total of 25 005 women who had had at least one prior caesarean delivery.
  
  
  METHODS
  Women who attempted VBAC with three or more prior caesareans were compared with those who attempted after one and two prior caesareans. Univariable and stratified analyses were used to select factors for multivariable analyses for maternal morbidity. Maternal characteristics were compared using a Student's t test, Mann-Whitney U test, chi-square test or Fisher's exact test, as appropriate.
  
  
  METHODS
  The primary outcome was composite maternal morbidity, defined as at least one of the following: uterine rupture, bladder or bowel injury, or uterine artery laceration. Secondary outcomes were VBAC success, blood transfusion and fever.
  
  
  RESULTS
  Of 25 005 women, 860 had three or more prior caesarean deliveries: 89 attempted VBAC and 771 elected for repeat caesarean. Of the 89 who attempted VBAC, there were no cases of composite maternal morbidity. They were also as likely to have a successful VBAC as women with one prior caesarean (79.8% versus 75.5%, adjusted OR 1.4, 95% CI 0.81-2.41, P = 0.22).
  
  
  CONCLUSIONS
  Women with three or more prior caesareans who attempt VBAC have similar rates of success and risk for maternal morbidity as those with one prior caesarean, and as those delivered by elective repeat caesarean.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA. cahilla@wustl.edu
authors.forename: A G
authors.initials: AG
authors.lastname: Cahill
authors.forename: M
authors.initials: M
authors.lastname: Tuuli
authors.forename: A O
authors.initials: AO
authors.lastname: Odibo
authors.forename: D M
authors.initials: DM
authors.lastname: Stamilio
authors.forename: G A
authors.initials: GA
authors.lastname: Macones
mesh_terms: D000328:Adult; D017604:Cesarean Section, Repeat / Q000009:adverse effects* / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D007744:Obstetric Labor Complications / Q000209:etiology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D012307:Risk Factors; D016064:Vaginal Birth after Cesarean / Q000009:adverse effects* / Q000706:statistics & numerical data