A common progenitor for retinal astrocytes and oligodendrocytes.
Developing neural tissue undergoes a period of neurogenesis followed by a period of gliogenesis. The lineage relationships among glial cell types have not been defined for most areas of the nervous system. Here we use retroviruses to label clones of glial cells in the chick retina. We found that almost every clone had both astrocytes and oligodendrocytes. In addition, we discovered a novel glial cell type, with features intermediate between those of astrocytes and oligodendrocytes, which we have named the diacyte. Diacytes also share a progenitor cell with both astrocytes and oligodendrocytes.
Rompani
Santiago B
SB
Departments of Genetics and Ophthalmology and Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Cepko
Constance L
CL
D000818:Animals; D000831:Animals, Newborn; D001253:Astrocytes / Q000737:chemistry / Q000145:classification / Q000166:cytology*; D002642:Chick Embryo; D002645:Chickens; D055495:Neurogenesis / Q000502:physiology; D009836:Oligodendroglia / Q000737:chemistry / Q000145:classification / Q000166:cytology*; D012160:Retina / Q000737:chemistry / Q000166:cytology* / Q000502:physiology; D013234:Stem Cells / Q000737:chemistry / Q000145:classification / Q000166:cytology*