Cytotoxic activity of epsilon-aminocaproylamino acids in breast cancer MCF-7 and fibroblast cell lines.
The effect of H-EACA-L-Cys(S-Bzl)-OH, H-EACA-L-Leu-OH, H-EACA-L-Nle-OH and EACA on the viability of MCF-7 and fibroblast cells was examined. The antibacterial activity of these compounds was also tested. H-EACA-L-Leu-OH and H-EACA-L-Nle-OH showed cytotoxic activity against MCF-7 and fibroblast cell lines, particularly in the highest studied 20 mM concentration. None of the examined dipeptides showed antibacterial activity.
Midura-Nowaczek
Krystyna
K
Department of Organic Chemistry, Medical University of Białystok, 1 Kiliński St., 15-223 Białystok, Poland. krystyna.midura-nowaczek@umwb.edu.pl
Markowska
Agnieszka
A
Krajewska
Dorota
D
Wołczyński
Sławomir
S
D015119:Aminocaproic Acid / Q000494:pharmacology*; D000933:Antifibrinolytic Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002460:Cell Line; D005260:Female; D005347:Fibroblasts / Q000187:drug effects*; D006801:Humans
D000933:Antifibrinolytic Agents; D000970:Antineoplastic Agents; D015119:Aminocaproic Acid