Degradation of human alpha- and beta-defensins by culture supernatants of Porphyromonas gingivalis strain 381.
Porphyromonas gingivalis produces proteases capable of degrading cytokines, host heme proteins and some antimicrobial peptides. In this study, we show that P. gingivalis culture supernatants fully or partially degrade human neutrophil peptide alpha-defensins and human beta-defensins after 30 min. This observation suggests that proteases from P. gingivalis degrade defensins and this activity could abrogate defensin-related innate immune functions.
Carlisle
M D
MD
Department of Periodontics, College of Dentistry, University of Iowa, Iowa City, Iowa 52242, USA.
Srikantha
R N
RN
Brogden
K A
KA
D001685:Biological Factors / Q000302:isolation & purification / Q000378:metabolism; D006801:Humans; D010447:Peptide Hydrolases / Q000302:isolation & purification / Q000378:metabolism; D016966:Porphyromonas gingivalis / Q000201:enzymology*; D023084:alpha-Defensins / Q000378:metabolism*; D023083:beta-Defensins / Q000378:metabolism*
D001685:Biological Factors; D023084:alpha-Defensins; D023083:beta-Defensins; D010447:Peptide Hydrolases