[A case of hemophagocytic syndrome complicated by acute viral hepatitis A infection].
Hemophagocytic syndrome (HPS) is a rare but serious condition that is histopathologically characterized by activation of macrophage or histiocytes with hemophagocytosis in bone marrow and reticuloendothelial systems. Clinically it presents with high fever, hepatosplenomegaly, pancytopenia, liver dysfunction, and hyperferritinemia. Hepatitis A virus is a very rare cause of secondary HPS. We report a case of a 22-year-old woman infected by hepatitis A virus who was consequently complicated with HPS. She presented typical clinical features of acute hepatitis A, and showed clinical and biochemical improvements. However, HPS developed as a complication of acute hepatitis A and the patient died of intraperitoneal bleeding caused by hepatic decompensation and disseminated intravascular coagulation.
Seo
Ji Young
JY
Department of Internal Medicine, Inje University College of Medicine, Sanggye Paik Hospital, Seoul, Korea.
Seo
Dong Dae
DD
Jeon
Tae Joo
TJ
Oh
Tae Hoon
TH
Shin
Won Chang
WC
Choi
Won Choong
WC
Yoo
Soo Jin
SJ
Han
Tae Hee
TH
D000208:Acute Disease; D004211:Disseminated Intravascular Coagulation / Q000150:complications; D005260:Female; D006470:Hemorrhage / Q000150:complications; D006506:Hepatitis A / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D017114:Liver Failure, Acute / Q000150:complications; D051359:Lymphohistiocytosis, Hemophagocytic / Q000150:complications / Q000175:diagnosis*; D014057:Tomography, X-Ray Computed; D055815:Young Adult