title: Medial temporal lobe dysfunction during encoding and retrieval of episodic memory in non-demented APOE epsilon4 carriers.
abstract: Presence of the apolipoprotein E (APOE) epsilon4 allele is linked to an increased risk to develop Alzheimer's dementia (AD). However, there are controversial data concerning the impact of the APOE genotype on cognitive functioning and brain activity in healthy subjects. We used event-related functional magnetic resonance imaging (fMRI) to investigate the effects of APOE genotype on spatial contextual memory encoding and retrieval success in healthy older adults. Eighteen subjects (eight APOE4 heterozygotes (epsilon4+) and 10 non-carriers (epsilon4-), mean age 60.0+/-5.0 years) were included in the present analysis. Behaviorally, epsilon4+ subjects performed significantly worse than epsilon4- subjects in item memory and spatial context retrieval. fMRI data revealed that epsilon4+ subjects, compared to epsilon4-subjects, predominantly showed an increase of neural activity specific to encoding of items and their spatial context in prefrontal, temporal and parietal regions. In contrast, epsilon4+ subjects showed activity decreases in the right amygdala during successful item recognition and in the prefrontal cortex bilaterally during spatial context retrieval when compared to epsilon4- subjects. While the activity increases during encoding may reflect compensatory activity in the attempt to maintain normal performance, the decreases during retrieval indicate incipient neural decline in epsilon4+ subjects. These data highlight that preclinical ApoE-related changes in neural activity are not unidirectional but dissociate depending on the memory phase, i.e., encoding or retrieval.
authors.affiliation: Cognitive Neurology Section, Institute of Neuroscience and Medicine (INM-3), Research Centre Jülich, Jülich, Germany. juraj.kukolja@uk-koeln.de
authors.forename: J
authors.initials: J
authors.lastname: Kukolja
authors.forename: C M
authors.initials: CM
authors.lastname: Thiel
authors.forename: T
authors.initials: T
authors.lastname: Eggermann
authors.forename: K
authors.initials: K
authors.lastname: Zerres
authors.forename: G R
authors.initials: GR
authors.lastname: Fink
mesh_terms: D000368:Aged; D053327:Apolipoprotein E4 / Q000235:genetics*; D001519:Behavior; D001921:Brain / Q000503:physiopathology; D003704:Dementia / Q000235:genetics; D005260:Female; D006579:Heterozygote; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D012044:Regression Analysis; D013028:Space Perception; D013702:Temporal Lobe / Q000503:physiopathology*
chemical_list: D053327:Apolipoprotein E4