Fighting back: peptidomimetics as a new weapon in the battle against antibiotic resistance.
The discovery, development, and clinical exploitation of antibiotics with new mechanisms of action is a top priority in the battle against untreatable infectious diseases. Peptidomimetics can successfully control infections caused by multidrug-resistant pathogens. This Perspective discusses findings in a recent Science paper on a member of this class of therapeutic agents that targets bacterial outer-membrane synthesis.
Bragonzi
Alessandra
A
Infections and Cystic Fibrosis Unit, Division of Immunology, Transplantation, and Infectious Diseases, San Raffaele Scientific Institute, Milano, Italy. bragonzi.alessandra@hsr.it
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D032701:Biomimetics; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D006801:Humans; D051379:Mice; D008826:Microbial Sensitivity Tests; D018805:Sepsis / Q000188:drug therapy / Q000382:microbiology
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides