title: A Mediterranean diet rich in virgin olive oil may reverse the effects of the -174G/C IL6 gene variant on 3-year body weight change.
abstract: Only a few studies have analyzed the effects of the potential interaction between the -174G/C polymorphism of IL6 gene and the adherence to the Mediterranean diet (MD) on adiposity indexes. Our aim was to investigate the interplay between the -174G/C polymorphism of the IL6 gene and a Mediterranean-style diet on body weight changes after 3 years of nutritional intervention in a high cardiovascular risk population. A total of 737 participants, aged 55-80 years were assigned to a low-fat diet or to a Mediterranean-style diet group with high intake of virgin olive oil (VOO) or nuts. Anthropometric measurements were taken at baseline and after 3-year follow-up. The -174G/C polymorphism of the IL6 gene was genotyped. Minor allele frequency (C) was 0.39. At baseline, the CC genotype was associated with higher measures of adiposity. After 3 years, a significant interaction (p=0.028) was found between the polymorphism (GG+GC versus CC) and the nutritional intervention: CC subjects following the MD+VOO had the lowest body weight gain. In conclusion, at baseline, CC subjects for the -174G/C polymorphism of IL6 had the highest body weight and BMI. However, after 3 years of nutritional intervention with MD+VOO, these subjects were predicted to have the greatest reduction in body weight.
authors.affiliation: Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Razquin
authors.forename: J Alfredo
authors.initials: JA
authors.lastname: Martinez
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Martinez-Gonzalez
authors.forename: Joaquin
authors.initials: J
authors.lastname: Fernández-Crehuet
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Santos
authors.forename: Amelia
authors.initials: A
authors.lastname: Marti
mesh_terms: D000368:Aged; D001794:Blood Pressure; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000453:epidemiology; D004247:DNA / Q000097:blood / Q000235:genetics / Q000302:isolation & purification; D003920:Diabetes Mellitus / Q000235:genetics; D038441:Diet, Mediterranean; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009754:Nuts; D000069463:Olive Oil; D010938:Plant Oils / Q000494:pharmacology*; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D015850:Interleukin-6; D000069463:Olive Oil; D010938:Plant Oils; D004247:DNA