[The expression and significance of Pin1 and CyclinD1 in adult papilloma of larynx].
OBJECTIVE
To study the expression and relationship of Pin1 and CyclinD1 in adult papilloma of larynx, and the effect of both in laryngeal papilloma's canceration.


METHODS
Ninety-two cases of paraffin section with immunoperoxidase (SP) staining method was used to detect the distribution of Pin1 and CyclinD1 in 10 cases of laryngeal normal epithelial tissue, 39 cases of laryngeal papilloma, 27 cases of laryngeal papilloma with middle, severe atypical hyperplasia and 16 cases of laryngeal carcinoma.


RESULTS
The distribution of Pin1 and CyclinD1 increased gradually from laryngeal normal epithelial tissue to laryngeal carcinoma (P<0.05); No difference of the expression of CyclinD1 (not including Pin1, for Pin1, P=0.009) was found between laryngeal papilloma and laryngeal papilloma with middle, severe atypical hyperplasia (P>0.0125), but there had significant difference of the expression of Pin1 and CyclinD1 among the rest groups; There was significantly direct correlation between the expression of Pin1 and CyclinD1 (P<0.05).


CONCLUSIONS
The hyper-expressions of Pin1 and CyclinD1 may play a key role in laryngeal papilloma's malignant change. Pin1 up-regulating the expressions of cyclinD1 possibly participate in its malignant change.
Fan
Guoliang
G
Department of Otolaryngology, Shengjing Hospital, China Medical University, Shenyang, 110003, China.
Wang
Dali
D
Fan
Xinlong
X
Wang
Tie
T
D000328:Adult; D000368:Aged; D019938:Cyclin D1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D010212:Papilloma / Q000378:metabolism* / Q000473:pathology; D019696:Peptidylprolyl Isomerase / Q000378:metabolism*; D055815:Young Adult
C530104:CCND1 protein, human; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D019938:Cyclin D1; C000606846:PIN1 protein, human; D019696:Peptidylprolyl Isomerase