Identification and determination of antihypertonics from the group of angiotensin-convertase inhibitors by densitometric method in comparition with HPLC method.
Conditions have been elaborated for the identification of all the compounds belonging to the group of angiotensin convertase inhibitors: lisinopril, quinapril, ramipril, spirapril, moexipril, trandolapril, benazepril, cilazapril, fosinopril, captopril, enalapril, imidapril and zofenopril by thin-layer chromatography. The selected conditions were used to design the densitometric method for the content determination of the above mentioned compounds in substances and medicines. The statistical data obtained for the designed method indicate adequate accuracy and precision.
Wyszomirska
Elzbieta
E
Department of Basic and Applied Pharmacy, National Medicines Institute, Warszawa, Poland. ewyszomirska@il.waw.pl
Czerwińska
Krystyna
K
Mazurek
Aleksander P
AP
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000032:analysis*; D000959:Antihypertensive Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002855:Chromatography, Thin Layer / Q000379:methods*; D003720:Densitometry / Q000379:methods*
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents