Synthesis and characterization of collagen/hydroxyapatite: magnetite composite material for bone cancer treatment.
Our purpose was obtaining and characterizing a complex composite system with multifunctional role: bone graft material and hyperthermia generator necessary for bone cancer therapy. The designed system was a magnetite enriched collagen/hydroxyapatite composite material, obtained by a co-precipitation method. Due to the applied electromagnetic field the magnetite will induce hyperthermia and cause tumoral cell apoptosis. The complex bone graft system was characterised by XRD, FTIR and SEM, while the hyperthermia was quantify by measuring the temperature increase due to the applied alternative electromagnetical field.
Andronescu
Ecaterina
E
Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 1-7 Polizu Street, 011061 Bucharest, Romania.
Ficai
Maria
M
Voicu
Georgeta
G
Ficai
Denisa
D
Maganu
Maria
M
Ficai
Anton
A
D001859:Bone Neoplasms / Q000628:therapy*; D016025:Bone Transplantation; D001842:Bone and Bones; D002128:Calcium Metabolism Disorders / Q000628:therapy; D003094:Collagen / Q000138:chemical synthesis / Q000737:chemistry; D017886:Durapatite / Q000138:chemical synthesis / Q000737:chemistry; D005109:Extracellular Matrix; D052203:Ferrosoferric Oxide
D003094:Collagen; D017886:Durapatite; D052203:Ferrosoferric Oxide