Sequential reaction of arynes via insertion into the pi-bond of amides and trapping reaction with dialkylzincs.
The sequential transformation of arynes into ortho-disubstituted arenes is achieved by a one-pot procedure using formamides and dialkylzincs. This reaction proceeded via a route involving the trapping reaction of the formal [2 + 2] cycloaddition adducts or quinone methides generated by the insertion of arynes into the C=O bond of amides.
Yoshioka
Eito
E
School of Pharmacy, Hyogo University of Health Sciences, Minatojima, Chuo-ku, Kobe 650-8530, Japan.
Kohtani
Shigeru
S
Miyabe
Hideto
H
D000577:Amides / Q000737:chemistry*; D017967:Zinc Compounds / Q000737:chemistry*
D000577:Amides; D017967:Zinc Compounds