title: Association between transforming growth factor beta1 polymorphisms and atrial fibrillation in essential hypertensive subjects.
abstract: BACKGROUND
  The association of TGF beta1 polymorphisms and atrial fibrillation (AF) in essential hypertensive (EH) subjects remains unknown. Methods EH subjects with AF (EH+AF+) and sinus rhythm (EH+AF-) were enrolled. The polymorphisms of +869 T --> C at codon 10 and + 915 G --> C at codon 25, were genotyped. The clinical characteristics including serum TGF beta1 levels were detected.
  
  
  RESULTS
  The GG genotypes of TGF beta1 +915 G --> C at codon 25 were more prevalent in subjects from EH+AF+ group than those from EH+AF- group (P = 0.009). The subjects with GG genotype from EH+AF+ group had the highest mean serum TGF beta1 level, which was significantly higher than that of GG genotype subjects from EH+AF- group (3.18 +/- 0.24 ng/dl vs.2.29 +/- 0.14 ng/dl, P < 0.05). Multiple analyses revealed that the TGF beta1 GG genotype of +915 G --> C at codon 25 presented a 3.09 times higher risk in developing AF in the multivariate model after adjusting for age and gender.
  
  
  CONCLUSIONS
  The polymorphisms of TGF beta1 +915 G --> C at codon 25 were associated with occurrence of AF and serum TGF beta1 level in EH subjects.
authors.affiliation: Department of Interventional Radiology, The Second Hospital of Shandong University, Shangdong, PR China.
authors.forename: Yongzheng
authors.initials: Y
authors.lastname: Wang
authors.forename: Xuwei
authors.initials: X
authors.lastname: Hou
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Li
mesh_terms: D001281:Atrial Fibrillation / Q000235:genetics*; D003062:Codon; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D053773:Transforming Growth Factor beta1 / Q000097:blood / Q000235:genetics*
chemical_list: D003062:Codon; D053773:Transforming Growth Factor beta1