title: Characterization of two low pathogenic avian influenza viruses isolated in Hungary in 2007.
abstract: Two low pathogenic (LP) avian influenza virus strains, A/mallard/Hungary/19616/07 (H3N8) and A/mute swan/Hungary/5973/07 (H7N7), isolated as part of the National Surveillance Program in Hungary, were fully sequenced and characterized. The two viruses showed the closest phylogenetic relationship regarding their acidic polymerase genes. The H7N7 Hungarian virus and some H5N2 influenza viruses isolated from Korean pigs appeared to have their basic polymerase gene 1 from a relatively recent common ancestor. The matrix gene nucleotide sequence of each Hungarian virus showed close relationship with contemporaneous Czech H3N8 mallard isolates, which belonged to distinct phylogenetic branches. The non-structural protein genes belonged to different alleles, rendering a peculiar characteristic to the H7N7 isolate compared to the so far analyzed Eurasian H7 viruses. The surface glycoprotein genes of the H3N8 isolate showed a close phylogenetic relationship and high nucleotide identities to H3N8 subtype isolates from Northern Europe collected in 2003-2006, and to an H3N2 isolate in Italy in 2006, extending the perceptions of this HA subtype across Northern and Southern Europe close to this period. These findings provide further data to the diversity of influenza viruses found in wild migratory birds and present useful information for large scale studies on influenza virus evolution.
authors.affiliation: Department of Virology, Central Agricultural Office Veterinary Diagnostic Directorate, Tábornok u. 2, H-1581 Budapest, Hungary.
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Szeleczky
authors.forename: Adám
authors.initials: A
authors.lastname: Bálint
authors.forename: Péter
authors.initials: P
authors.lastname: Gyarmati
authors.forename: Giorgi
authors.initials: G
authors.lastname: Metreveli
authors.forename: Adám
authors.initials: A
authors.lastname: Dán
authors.forename: Krisztina
authors.initials: K
authors.lastname: Ursu
authors.forename: Sándor
authors.initials: S
authors.lastname: Belák
authors.forename: Béla
authors.initials: B
authors.lastname: Lomniczi
authors.forename: István
authors.initials: I
authors.lastname: Kiss
mesh_terms: D000818:Animals; D000835:Animals, Wild / Q000821:virology; D046090:Anseriformes / Q000821:virology; D019951:DNA Polymerase beta / Q000235:genetics; D004372:Ducks / Q000821:virology; D005814:Genes, Viral / Q000235:genetics; D006023:Glycoproteins / Q000235:genetics; D006814:Hungary / Q000453:epidemiology; D053123:Influenza A Virus, H3N8 Subtype / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D053126:Influenza A Virus, H7N7 Subtype / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D005585:Influenza in Birds / Q000453:epidemiology / Q000821:virology*; D010802:Phylogeny; D014764:Viral Proteins / Q000235:genetics
chemical_list: D006023:Glycoproteins; D014764:Viral Proteins; C415367:DNA polymerase beta2; D019951:DNA Polymerase beta