title: [Effect of fluoride on human hypothalamus-hypophysis-testis axis hormones].
abstract: OBJECTIVE
  To study of endocrine disturbing effect of fluoride on human hypothalamus-hypophysis-testis axis hormones.
  
  
  METHODS
  Sunying County, Kaifeng City was selected as polluted district which the fluoride in drinking water was 3.89 mg/L, and Shenlilou county was selected as control district which the fluoride was less than 1.0 mg/L. 150 individual lived there more than 5 years were srlected randomly. And investigated by medical examination, then blood and urine sample were collected, and the serum level of gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), testosterone (T) and estradiol (E2) were measured by RIA method, and the urine level of fluoride were measured. Other than that, the concentration of fluoride in the water, food, soil and air were detected by the standard methods.
  
  
  RESULTS
  The concentrations of fluoride in the water, food and soil of the fluoride polluted district were significantly higher than those of control district (P < 0.05), and the concentration fluoride in the air of two district were not found. There was no significant difference of serum level of GnRH between fluoride polluted district and control district (P > 0.05). The serum level of LH in men of fluoride polluted district was significantly higher than that of control group (P < 0.05), and the serum level of T in men of fluoride polluted district was significantly less than that of control group (P < 0.05). There was no significant difference of serum level of LH between fluoride polluted district and control district (P > 0.05), and the serum level of T in women of fluoride polluted district was significantly higher than that of control group (P < 0.05). There was no significant difference of serum level of E2 between fluoride polluted district and control district (P > 0.05).
  
  
  CONCLUSIONS
  Fluoride could effect hormone levels of each layer of the hypothalamus-hypophysis-testis axis, and show the reproductive endocrine disturbing effects. The reproductive endocrine disturbing effects of male maybe more severe than those of female.
authors.affiliation: Department of Environmental Hygiene, College of Public Health, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Pengfei
authors.initials: P
authors.lastname: Hao
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Ma
authors.forename: Xuemin
authors.initials: X
authors.lastname: Cheng
authors.forename: Yue
authors.initials: Y
authors.lastname: Ba
authors.forename: Jingyuan
authors.initials: J
authors.lastname: Zhu
authors.forename: Liuxin
authors.initials: L
authors.lastname: Cui
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002681:China; D052244:Endocrine Disruptors / Q000009:adverse effects / Q000032:analysis; D004781:Environmental Exposure / Q000009:adverse effects*; D004958:Estradiol / Q000097:blood; D005260:Female; D005459:Fluorides / Q000009:adverse effects* / Q000032:analysis; D007987:Gonadotropin-Releasing Hormone / Q000097:blood*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D013737:Testis / Q000187:drug effects*; D013739:Testosterone / Q000097:blood; D055815:Young Adult
chemical_list: D052244:Endocrine Disruptors; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005459:Fluorides