[Research progress in treatment of bone defect with osteomyelitis by using drug-carried bionic nano-bone].
OBJECTIVE
To review the research progress in the treatment of bone defect or osteomyelitis with drug-carried bionic nano-bone so as to offer some theoretic supports and experimental references for those relative researchers.


METHODS
The related literature was reviewed. The research progress in the treatment of bone defect or osteomyelitis with drug-carried bionic nano-bone was analyzed, which included the designing and preparing of drug-carried nano composites, the way of making infected bone defect animal models, and the general steps, test indexes and results.


RESULTS
Traumatic osteomyelitis and bone defect were two kinds of disease to difficulty cure in nowadays clinical orthopaedics. The osteomyelitis, especially chronic one was quite troublesome during the treatments. Many researchers made artificial bone with nano-materials and added drugs into them by various ways for the purpose of controlling infection and repairing bone defection simultaneously. But these researches were still at the laboratory phase, lacking the criterions of making relative animal models, and needed to be improved in the way of drug slow-releasing and nano-scaffold producing.


CONCLUSIONS
The drug-carried bionic nano-bone as a kind of newly emerging replacement material has splendid effects in the treatments of traumatic large area bone defect or osteomyelitis and will have a brilliant future.
Gong
Jiahong
J
Department of Orthopaedics, Subei People's Hospital of Jiangsu Province, Yangzhou Jiangsu, 225001, P.R. China.
Wang
Jingcheng
J
Wang
Daxin
D
D000818:Animals; D040761:Biomimetic Materials; D001847:Bone Diseases / Q000601:surgery; D018786:Bone Substitutes; D004337:Drug Carriers; D049329:Nanostructures; D010019:Osteomyelitis / Q000601:surgery*
D018786:Bone Substitutes; D004337:Drug Carriers