title: [Expression and clinical significance of Ang-2 and MMP-7 in laryngeal carcinoma].
abstract: OBJECTIVE
  To investigate the expression and clinical significance of Ang-2 and MMP-7 protein in laryngeal carcinoma tissue.
  
  
  METHODS
  Immunohistochemical technique was used to detect the expression of Ang-2 and MMP-7 protein in 65 tissues of laryngeal carcinoma and 34 biopsies of adjacent non- cancerous tissue. The relationship between the expression of Ang-2 and MMP-7 and invasion, metastasis or prognosis in laryngeal carcinoma tissue was analyzed.
  
  
  RESULTS
  The positive rates of Ang-2 and MMP-7 were significantly higher in laryngeal carcinoma tissue than those in adjacent non-cancerous tissue (P < 0.05). The level of Ang-2 and MMP-7 expression had no significant correlations with the age and course as well as the smoking, drinking, histological differentiation of carcinoma and clinical classification (P > 0.05). While the expression of Ang-2 significantly differed between patients with different T stage and clinical stage (P < 0.05), and the expression of MMP-7 was notably correlated with the T stage, clinical stage and lymph node metastases (P < 0.05). There was a correlation between the expression of Ang-2 and MMP-7 (P < 0.05). The Kaplan-Meier survival analysis showed that patients with positive expression of Ang-2 had worse overall survival (P < 0.05). However, MMP-7 expression was not related to overall survival or disease-free survival (all P > 0.05). Cox regression analysis indicated that Ang-2 and MMP-7 expression were independent prognostic factors of laryngeal carcinoma.
  
  
  CONCLUSIONS
  Overexpression of Ang-2 and MMP-7 was observed in laryngeal carcinoma and they might be served as an objective indicator for biological behaviour and prognosis.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Luzhou Medical College, Luzhou, 646000, China. qin-lzm@163.com
authors.forename: Gang
authors.initials: G
authors.lastname: Qin
authors.forename: Wenjun
authors.initials: W
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Yu
authors.forename: Zhuoping
authors.initials: Z
authors.lastname: Liang
authors.forename: Zuyao
authors.initials: Z
authors.lastname: Chen
authors.forename: Wanrong
authors.initials: W
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D042702:Angiopoietin-2 / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D020783:Matrix Metalloproteinase 7 / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
chemical_list: D042702:Angiopoietin-2; C060932:MMP7 protein, human; D020783:Matrix Metalloproteinase 7