Osteoarthritis: another component of metabolic syndrome?
Osteoarthritis (OA) has become a major public health problem not only because of its increasing prevalence worldwide but also because of its frequent association with cardiovascular disease, the leading cause of death in industrialized countries. There is growing evidence that OA is not simply a disease related to aging or mechanical stress of joints but rather a "metabolic disorder" in which various interrelated lipid, metabolic, and humoral mediators contribute to the initiation and progression of the disease process. Indeed, OA has been linked not only to obesity but also to other cardiovascular risk factors, namely, diabetes, dyslipidemia, hypertension, and insulin resistance.
Velasquez
Manuel T
MT
Division of Renal Diseases and Hypertension, The George Washington University, Washington, District of Columbia 20037, USA. mvelasquez@mfa.gwu.edu
Katz
James D
JD
D000328:Adult; D000368:Aged; D016207:Cytokines / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D050171:Dyslipidemias / Q000150:complications; D005227:Fatty Acids / Q000502:physiology; D005947:Glucose / Q000502:physiology; D006728:Hormones / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000150:complications; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins / Q000502:physiology; D024821:Metabolic Syndrome / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism; D009765:Obesity / Q000150:complications; D010003:Osteoarthritis / Q000150:complications* / Q000453:epidemiology / Q000235:genetics; D017382:Reactive Oxygen Species; D012307:Risk Factors; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology; D014481:United States / Q000453:epidemiology
D016207:Cytokines; D005227:Fatty Acids; D006728:Hormones; D036341:Intercellular Signaling Peptides and Proteins; D017382:Reactive Oxygen Species; D014157:Transcription Factors; D009569:Nitric Oxide; D005947:Glucose