Microarray analysis of the liver in metallothionein-III null mice treated with cadmium.
In order to elucidate the effect of metallothionein (MT)-III on hepatic gene expression altered by cadmium (Cd), we examined gene expression patterns in the liver of MT-III null mice and wild-type mice after Cd injection using a DNA microarray containing 35,852 genes. In a comparison between Cd-injected MT-III null mice and Cd-injected wild-type mice, 9 genes were found to be up-regulated and 28 genes-including serum amyloid A1 (SAA-1) and SAA-2--were down-regulated.
Honda
Akiko
A
Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University, Nagoya, Aichi, Japan.
Komuro
Hiroaki
H
Nagase
Hisamitsu
H
Hozumi
Isao
I
Inuzuka
Takashi
T
Hara
Hideaki
H
Fujiwara
Yasuyuki
Y
Satoh
Masahiko
M
D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D000090023:Metallothionein 3; D051379:Mice; D009419:Nerve Tissue Proteins / Q000502:physiology*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods*; D000685:Serum Amyloid A Protein / Q000032:analysis
D000090023:Metallothionein 3; D009419:Nerve Tissue Proteins; D000685:Serum Amyloid A Protein; D002104:Cadmium