Squamous cell carcinoma of the conjunctiva: analysis of fifteen cases.
BACKGROUND
To document various clinical presentations and management options of conjunctival squamous cell carcinoma (CSCC) in patients attending ophthalmic out patients department (OPD) of a tertiary care centre. This case series was carried out in the Department of Ophthalmology Civil Hospital and, Dow University of Health Sciences, Karachi and were reviewed from June 2004 to December 2007.


METHODS
Socio-demographic data and clinical features of patients with biopsy proven conjunctival squamous cell carcinoma were recorded and analysed. All patients underwent complete ophthalmic examination by a fellow ophthalmologist and clinical findings were recorded on a prescribed Performa. Data was analysed in terms of frequency, means and median by SPSS for windows V.15.


RESULTS
Seventy-two percent of the patients were male and 28% were female, more than 80% of patients were in the age group of seventy years and above. Eighteen percent of patients developed intraocular invasion and the eyes had to be enucleated.


CONCLUSIONS
CSCC occurs in sun damaged ocular surface usually at limbus, elderly men are more commonly involve, recurrence is a feature of disease and high risk in older individual. In our treatment we used various therapies, excision with clear margin, topical mitomycin C adjunctive cryotherapy and amniotic graft.
Baig
Mirza Shafiq Ali
MS
Department of Ophthalmology Unit-I, Dow University of Health Sciences Karachi, Pakistan. drshafiqbaig@gmail.com
Dareshani
Shehla
S
Ali
Mir Amjad
MA
Khan
Mohammad Shafique
MS
D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000601:surgery / Q000628:therapy; D003228:Conjunctiva / Q000473:pathology*; D003230:Conjunctival Neoplasms / Q000175:diagnosis* / Q000601:surgery / Q000628:therapy; D017679:Cryotherapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use; D009364:Neoplasm Recurrence, Local; D012307:Risk Factors
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin