Influenza A (H1N1) pneumonia in an immunossupressed patient after heart transplantation.
The role of the immune response during Influenza H1N1 virus infection is not yet fully established, but it is believed that it decisively participates in the severity of the disease as well as in the development of acute respiratory distress syndrome. The role of immunomodulating therapies in the control of viral infections is not a consensus either, and data from the literature defining the indications for their use are lacking. The present report is, to our knowledge, the first on a heart transplant patient who developed H1N1 virus infection and had a favorable outcome, thus generating discussion on the real role of immunosuppressive therapy as a risk factor for the severe form of the disease.
Bacal
Fernando
F
Instituto do Coração, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil. fbacal@uol.com.br
Seguro
Luis Fernando
LF
Ogawa
Tania
T
Mangini
Sandrigo
S
Fiorelli
Alfredo
A
Bocchi
Edimar
E
D005260:Female; D016027:Heart Transplantation / Q000276:immunology*; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000276:immunology / Q000821:virology*; D008875:Middle Aged; D011024:Pneumonia, Viral / Q000209:etiology*; D012128:Respiratory Distress Syndrome / Q000517:prevention & control
D007166:Immunosuppressive Agents