title: Cilia self-organize in response to planar cell polarity and flow.
abstract: Cilia drive fluid flow in development and physiology, but this requires that all cilia in a tissue orient the same way. Earlier studies indicated that both planar cell polarity (PCP) signalling and cilia-generated fluid flows could influence ciliary orientation. We now learn how asymmetric localization of PCP proteins influences the position and orientation of cilia to control the direction of flow.
authors.affiliation: Department of Biochemistry & Biophysics, UCSF, San Francisco, CA 94158, USA. wallace.marshall@ucsf.edu
authors.forename: Wallace F
authors.initials: WF
authors.lastname: Marshall
mesh_terms: D000818:Animals; D016764:Cell Polarity; D002555:Cerebrospinal Fluid / Q000378:metabolism; D002923:Cilia / Q000378:metabolism; D004805:Ependyma / Q000166:cytology* / Q000196:embryology / Q000378:metabolism; D025461:Feedback, Physiological; D006801:Humans; D040542:Mechanotransduction, Cellular; D009024:Morphogenesis; D009038:Motion; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D013314:Stress, Mechanical
chemical_list: C431577:Ltap protein, mouse; D009419:Nerve Tissue Proteins; D011993:Recombinant Fusion Proteins