title: QA-driven guidelines generation for bacteriotherapy.
abstract: OBJECTIVE
  We propose a question-answering (QA) driven generation approach for automatic acquisition of structured rules that can be used in a knowledge authoring tool for antibiotic prescription guidelines management.
  
  
  METHODS
  The rule generation is seen as a question-answering problem, where the parameters of the questions are known items of the rule (e.g. an infectious disease, caused by a given bacterium) and answers (e.g. some antibiotics) are obtained by a question-answering engine.
  
  
  RESULTS
  When looking for a drug given a pathogen and a disease, top-precision of 0.55 is obtained by the combination of the Boolean engine (PubMed) and the relevance-driven engine (easyIR), which means that for more than half of our evaluation benchmark at least one of the recommended antibiotics was automatically acquired by the rule generation method.
  
  
  CONCLUSIONS
  These results suggest that such an automatic text mining approach could provide a useful tool for guidelines management, by improving knowledge update and discovery.
authors.affiliation: Medical Informatics Service, University Hospitals of Geneva and University of Geneva.
authors.forename: Emilie
authors.initials: E
authors.lastname: Pasche
authors.forename: Douglas
authors.initials: D
authors.lastname: Teodoro
authors.forename: Julien
authors.initials: J
authors.lastname: Gobeill
authors.forename: Patrick
authors.initials: P
authors.lastname: Ruch
authors.forename: Christian
authors.initials: C
authors.lastname: Lovis
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D057225:Data Mining; D003661:Decision Support Techniques; D001330:Electronic Data Processing; D006801:Humans; D016247:Information Storage and Retrieval; D017410:Practice Guidelines as Topic; D039781:PubMed; D057386:Search Engine; D018875:Vocabulary, Controlled
chemical_list: D000900:Anti-Bacterial Agents