title: Determination of stability constants and acute toxicity of potential hepatotropic gadolinium complexes.
abstract: Due to their high specificity for the hepatobiliary system, iminodiacetic acid derivatives are known to form a class of hepatobiliary agents. In this paper we present new hepatotropic gadolinium complexes to be used as potential MRI contrast agents. Derivatives of N-(2-phenylamine-2-oxoethyl) iminodiacetic acid are introduced as ligands into such complexes. In this way, we hope to achieve a valuable diagnostic tool for investigating of pathological changes in the liver. Stability constants of complexes were determined by potentiometric titration in 0.1 mol L(-1) NaNO3 solution at 20.0 +/- 0.1 degrees C. Stability and selectivity constants were also determined for endogenous metal ions such as Cu2+, Ca2+, and Zn2+ with the use of SUPERQUAD computer program. Acute toxicity of new gadolinium complexes was assessed in mice and histopathology examinations were carried out.
authors.affiliation: Department of Pharmaceutical Chemistry and Drug Analysis, Medical University of Lódź, 1 Muszyńskiego St., 90-151 Lódź, Poland. elzbieta.mikiciuk-olasik@umed.lodz.pl
authors.forename: Elzbieta
authors.initials: E
authors.lastname: Mikiciuk-Olasik
authors.forename: Emilia
authors.initials: E
authors.lastname: Wojewoda
authors.forename: Ireneusz
authors.initials: I
authors.lastname: Bilichowski
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Witczak
authors.forename: Bolesław
authors.initials: B
authors.lastname: Karwowski
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Wagrowska-Danilewicz
authors.forename: Olga
authors.initials: O
authors.lastname: Stasikowska
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000737:chemistry*; D004355:Drug Stability; D005260:Female; D005682:Gadolinium / Q000737:chemistry* / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D011199:Potentiometry; D023382:Toxicity Tests, Acute
chemical_list: D003287:Contrast Media; D005682:Gadolinium