title: Surgical spacer placement and proton radiotherapy for unresectable hepatocellular carcinoma.
abstract: Few potentially curative treatment options exist apart from hepatic resection for patients with huge hepatocellular carcinoma (HCC). Proton radiotherapy is a promising new modality which has an inherent anti-tumor effect against HCC. However, the application of proton radiotherapy for tumors adjacent to the gastrointestinal tract is restricted because the tolerance dose of the intestine is extremely low. A novel two-step treatment was developed with surgical spacer placement and subsequent proton radiotherapy to administer proton radiotherapy with curative intent. This report presents a case of a patient with a huge unresectable HCC treated by this method who achieved disease-free survival of more than 2 years. This new strategy may potentially be an innovative and standard therapy for unresectable HCC in the near future.
authors.affiliation: Department of Surgery, Division of Hepato-Biliary-Pancreatic Surgery, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
authors.forename: Shohei
authors.initials: S
authors.lastname: Komatsu
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hori
authors.forename: Takumi
authors.initials: T
authors.lastname: Fukumoto
authors.forename: Masao
authors.initials: M
authors.lastname: Murakami
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Hishikawa
authors.forename: Yonson
authors.initials: Y
authors.lastname: Ku
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000601:surgery; D018572:Disease-Free Survival; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011138:Polytetrafluoroethylene; D061766:Proton Therapy; D013526:Surgical Mesh; D014057:Tomography, X-Ray Computed
chemical_list: D011138:Polytetrafluoroethylene