title: Serum folate and DDT isomers and metabolites are inversely associated in Chinese women: a cross-sectional analysis.
abstract: BACKGROUND
  Vitamin nutritional status may influence some xenobiotic metabolism or vice versa.
  
  
  METHODS
  This analysis examines the relationship between B-vitamin concentrations and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDT) isomers and metabolites in healthy women. Serum pp'DDT, pp'DDE, pp'DDD, op'DDT, op'DDE, and serum folate, cysteine, and vitamins B6 and B12 were measured in 296 nonsmoking female textile workers (21-34 yr) in Anhui, China. Mean (SD) age and body mass index of this cohort were 24.9 (1.5) y and 19.7 (2.0) kg/m(2), respectively.
  
  
  RESULTS
  Median pp'DDT, pp'DDE, pp'DDD, op'DDT, and op'DDE were 1.5, 29.2, 0.22, 0.17, and 0.09 ng/g, respectively. Median folate and cysteine were 9.2 and 200.0 nmol/L, respectively. Folate was significantly inversely associated with pp'DDT and pp'DDE: beta (95% confidence interval [CI]) = -0.23 (-0.39, -0.07) and -0.20 (-0.36, -0.05), respectively, and it was marginally associated with pp'DDD. Cysteine was significantly inversely associated with pp'DDT, beta (95% CI) = -0.69 (-1.00, -0.37); pp'DDE, beta (95% CI) = -0.32 (-0.62, -0.02); pp'DDD, beta (95% CI) = -0.31 (-0.59, -0.03); and op'DDT, beta (95% CI) = -0.35 (-0.68, -0.02).
  
  
  CONCLUSIONS
  Folate and cysteine are independently inversely associated with DDT isomers, adjusting for vitamins B6 and B12, age, and body mass index. These nutrients may play a role in DDT metabolism; however, it is also possible that DDT may exert a negative impact on folate and cysteine levels. Longitudinal studies are needed to ascertain the direction of this association.
authors.affiliation: Center for Population Genetics, University of Illinois at Chicago, School of Public Health, Illinois, USA. Larguelles@childrensmemorial.org
authors.forename: Lester M
authors.initials: LM
authors.lastname: Arguelles
authors.forename: Xue
authors.initials: X
authors.lastname: Liu
authors.forename: Scott A
authors.initials: SA
authors.lastname: Venners
authors.forename: Alayne G
authors.initials: AG
authors.lastname: Ronnenberg
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Li
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Jianhua
authors.initials: J
authors.lastname: Yang
authors.forename: Xiping
authors.initials: X
authors.lastname: Xu
authors.forename: Xiaobin
authors.initials: X
authors.lastname: Wang
mesh_terms: D000328:Adult; D002681:China; D003430:Cross-Sectional Studies; D003545:Cysteine / Q000097:blood; D003634:DDT / Q000097:blood*; D005260:Female; D005492:Folic Acid / Q000097:blood*; D006801:Humans; D007536:Isomerism; D016014:Linear Models; D011446:Prospective Studies; D014805:Vitamin B 12 / Q000097:blood; D025101:Vitamin B 6 / Q000097:blood; D055815:Young Adult
chemical_list: D025101:Vitamin B 6; D005492:Folic Acid; D003634:DDT; D003545:Cysteine; D014805:Vitamin B 12