First Zn(II) bowl-complexes modeling the tris(histidine) metallo-site of enzymes.
The bowl-shaped resorcin[4]arene-based ligand was prepared as a model of the trihistidine coordination core present in many mononuclear metalloenzymes. The -CH(2)-O-CH(2)- linkers connecting the imidazoles to the cavity allow three imidazoles to simultaneously bind a metal ion, and favor cis-coordination of two exchangeable ligands. The corresponding mononuclear Zn(II) complexes were shown to be capable of the selective guest binding and exchange at both endo and exo positions.
Visnjevac
Aleksandar
A
Laboratoire de Chimie et de Biochimie pharmacologiques et toxicologiques, Université Paris Descartes, CNRS UMR 8601 45, 75006 Paris, France.
Gout
Jérôme
J
Ingert
Nicolas
N
Bistri
Olivia
O
Reinaud
Olivia
O
D001665:Binding Sites; D006639:Histidine / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015032:Zinc / Q000737:chemistry*
D006639:Histidine; D015032:Zinc