Gene profiling in experimental models of eye growth: clues to myopia pathogenesis.
To understand the complex regulatory pathways that underlie the development of refractive errors, expression profiling has evaluated gene expression in ocular tissues of well-characterized experimental models that alter postnatal eye growth and induce refractive errors. Derived from a variety of platforms (e.g. differential display, spotted microarrays or Affymetrix GeneChips), gene expression patterns are now being identified in species that include chicken, mouse and primate. Reconciling available results is hindered by varied experimental designs and analytical/statistical features. Continued application of these methods offers promise to provide the much-needed mechanistic framework to develop therapies to normalize refractive development in children.
Stone
Richard A
RA
Department of Ophthalmology, University of Pennsylvania School of Medicine, Scheie Eye Institute, Philadelphia, PA 19104-6075, USA. stone@mail.upenn.edu
Khurana
Tejvir S
TS
D000818:Animals; D002645:Chickens; D004195:Disease Models, Animal; D005123:Eye / Q000254:growth & development*; D020869:Gene Expression Profiling; D006801:Humans; D051379:Mice; D046228:Microarray Analysis; D009216:Myopia / Q000235:genetics* / Q000503:physiopathology*; D011323:Primates; D012029:Refraction, Ocular / Q000235:genetics*; D012030:Refractive Errors / Q000235:genetics*