Advanced glycation end products and acute myocardial infarction.
OBJECTIVE
The aim of this study was to analyse the dynamics of advanced glycation end products (AGEs) after acute myocardial infarction (MI).


METHODS
Blood samples were taken from 20 non-diabetic patients with acute MI on the 1st, 2nd, 3rd and 5th day after the onset of symptoms. Serum AGE levels were estimated spectrofluorometrically.


RESULTS
A marked decrease in the AGE-specific fluorescence was observed, especially between the 1st and the 2nd days after MI.


CONCLUSIONS
The findings of this study tend to contradict the suggestion that AGEs are relatively stable markers of carbonyl stress. Although the reason for this is currently unknown, this observation may have implications for ongoing studies of AGEs in cardiovascular diseases.
Celec
Peter
P
Institute of Pathophysiology, Department of Molecular Biology, Faculty of Medicine, Comenius University, and 1st Department of Internal Medicine, Faculty Hospital, Bratislava, Slovak Republic. petercelec@gmail.com
Burská
Stella
S
Sebeková
Katarína
K
Kalousová
Marta
M
Zima
Tomás
T
Murín
Ján
J
D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D013050:Spectrometry, Fluorescence; D013997:Time Factors
D015415:Biomarkers; D017127:Glycation End Products, Advanced