Association of -308G/A polymorphism in the tumor necrosis factor-alpha gene promoter with susceptibility to development of hantavirus cardiopulmonary syndrome in the Ribeirão Preto region, Brazil.
Activation of the immune response in hantavirus cardiopulmonary syndrome (HCPS) leads to a high TNF production, probably contributing to the disease. The polymorphic TNF2 allele (TNF -308G/A) has been associated with increased cytokine production. We investigated the association of the TNF2 allele with the outcome of hantavirus infection in Brazilian patients. A total of 122 hantavirus-exposed individuals (26 presenting HCPS and 96 only hantavirus seroconversion) were studied. The TNF2 allele was more frequently found in HCPS patients than in individuals with positive serology for hantavirus but without a history of HCPS illness, suggesting that the TNF2 allele could represent a risk factor for developing HCPS.
Borges
Alessandra Abel
AA
Virology Research Center, School of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, Brazil.
Donadi
Eduardo Antônio
EA
Campos
Gelse Mazzoni
GM
Moreli
Marcos Lázaro
ML
de Sousa
Ricardo Luiz Moro
RL
Saggioro
Fabiano Pinto
FP
de Figueiredo
Glauciane Garcia
GG
Badra
Soraya Jabur
SJ
Deghaide
Neifi Hassan Saloum
NH
Figueiredo
Luiz Tadeu Moraes
LT
D000293:Adolescent; D000328:Adult; D000368:Aged; D001938:Brazil; D005260:Female; D020022:Genetic Predisposition to Disease; D018778:Hantavirus Infections / Q000235:genetics* / Q000821:virology; D018804:Hantavirus Pulmonary Syndrome / Q000235:genetics* / Q000821:virology; D006331:Heart Diseases / Q000235:genetics* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D013577:Syndrome; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D055815:Young Adult
D014409:Tumor Necrosis Factor-alpha