title: Modafinil effects on reinstatement of methamphetamine seeking in a rat model of relapse.
abstract: BACKGROUND
  Modafinil (Provigil) is a wake-promoting drug characterized by cognitive enhancing abilities. Recent clinical data have supported the use of modafinil for treatment of chronic psychostimulant addiction and relapse prevention.
  
  
  METHODS
  We used an intravenous methamphetamine (meth) self-administration procedure to assess the dose-dependent effects of modafinil on reinstatement following abstinence and after extinction on conditioned-cue and meth-primed reinstatement of meth seeking.
  
  
  RESULTS
  Modafinil attenuated active lever responding in multiple reinstatement conditions-context-induced, conditioned cue, and meth prime. The most pronounced and consistent effect was on meth-primed reinstatement, and modafinil did not reinstate meth seeking when tested alone.
  
  
  CONCLUSIONS
  These findings support clinical findings in humans that modafinil may be an effective therapeutic agent for the prevention of relapse in abstinent meth users.
authors.affiliation: Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, Charleston, SC 29425, USA.
authors.forename: Carmela M
authors.initials: CM
authors.lastname: Reichel
authors.forename: Ronald E
authors.initials: RE
authors.lastname: See
mesh_terms: D019969:Amphetamine-Related Disorders / Q000188:drug therapy* / Q000523:psychology; D000818:Animals; D016739:Behavior, Addictive / Q000188:drug therapy* / Q000517:prevention & control / Q000523:psychology; D001559:Benzhydryl Compounds / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage*; D000077408:Modafinil; D051381:Rats; D020318:Rats, Long-Evans; D055502:Secondary Prevention; D012646:Self Administration
chemical_list: D001559:Benzhydryl Compounds; D008694:Methamphetamine; D000077408:Modafinil