title: Circadian disruption induced by light-at-night accelerates aging and promotes tumorigenesis in young but not in old rats.
abstract: We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span, tumorigenesis and age-related dynamics of antioxidant enzymes activity in various organs in comparison to the rats maintained at the standard (12:12 light/dark) light/dark regimen. We found that exposure to constant light started at the age of 1 month accelerated spontaneous tumorigenesis and shortened life span both in male and female rats as compared to the standard regimen. At the same time, the exposure to constant light started at the age of 14 months failed to influence survival of male and female rats. While delaying tumors in males, constant light accelerated tumors in females. We conclude that circadian disruption induced by light-at-night started at the age of 1 month accelerates aging and promotes tumorigenesis in rats, however failed affect survival when started at the age of 14 months.
authors.affiliation: Petrozavodsk State University, Petrozavodsk 185910, Russia. aging@mail.ru
authors.forename: Irina A
authors.initials: IA
authors.lastname: Vinogradova
authors.forename: Vladimir N
authors.initials: VN
authors.lastname: Anisimov
authors.forename: Andrey V
authors.initials: AV
authors.lastname: Bukalev
authors.forename: Viktor A
authors.initials: VA
authors.lastname: Ilyukha
authors.forename: Evgeniy A
authors.initials: EA
authors.lastname: Khizhkin
authors.forename: Tatiana A
authors.initials: TA
authors.lastname: Lotosh
authors.forename: Anna V
authors.initials: AV
authors.lastname: Semenchenko
authors.forename: Mark A
authors.initials: MA
authors.lastname: Zabezhinski
mesh_terms: D000367:Age Factors; D000375:Aging / Q000528:radiation effects*; D000818:Animals; D002374:Catalase / Q000378:metabolism; D002940:Circadian Rhythm / Q000528:radiation effects*; D005260:Female; D008027:Light / Q000009:adverse effects*; D008136:Longevity / Q000528:radiation effects; D008297:Male; D009369:Neoplasms / Q000209:etiology*; D018384:Oxidative Stress / Q000528:radiation effects; D017440:Photoperiod; D010870:Pineal Gland / Q000528:radiation effects; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D002374:Catalase; D013482:Superoxide Dismutase