Synthesis of some novel analogues of 4-(1-Pyrrolidinyl) Piperidine and their effect on plasma glucose level.
In the present study some compounds of 4-(1-Pyrrolidinyl) Piperidine (I) have been synthesized. Structures of compounds were confirmed by using HNMR, IR, Mass and UV spectrophotometer techniques. All the derivatives (II, III, IV and V) and the parent compound (I) at the dose of 100 mg/kg were evaluated for their effect on plasma glucose level. Compound (II) was the only derivative which showed effect on plasma glucose level.
Mushtaq
Nousheen
N
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Karachi, Karachi, Pakistan. noshin_mushtaq@yahoo.com
Saify
Z S
ZS
Akhtar
Shamim
S
Arif
Muhammad
M
Haider
Saida
S
Saba
Nazish
N
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004353:Drug Evaluation, Preclinical; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010880:Piperidines