Where does the lactate come from? A rare cause of reversible inhibition of mitochondrial respiration.
Biguanide poisoning is associated with lactic acidosis. The exact mechanism of biguanide-induced lactic acidosis is not well understood. In the previous issue of Critical Care, Protti and colleagues demonstrated that biguanide-induced lactic acidosis may be due in part to a reversible inhibition of mitochondrial respiration. Thus, in the absence of an antidote, increased drug elimination through dialysis is logical.
Levy
Bruno
B
Service de Reanimation Médicale, CHU Nancy-Brabois, Vandoeuvre les Nancy, France. b.levy@chu-nancy.fr
Perez
Pierre
P
Perny
Jessica
J
D000140:Acidosis, Lactic / Q000139:chemically induced*; D001645:Biguanides / Q000009:adverse effects; D019069:Cell Respiration / Q000187:drug effects*; D006801:Humans; D008928:Mitochondria / Q000187:drug effects*
D001645:Biguanides