title: Engineering nanoscopic hydrogels via photo-crosslinking salt-induced polymer assembly for targeted drug delivery.
abstract: We report the preparation of biodegradable nanoscopic hydrogels and their application for targeted drug delivery. The nanogel is synthesized in a template-free method by photo-crosslinking salt-induced polymer assemblies. With convenient incorporation of targeted lactosyl moieties, the nanogels efficiently deliver doxorubicin to HepG2 cells through receptor-mediated internalization.
authors.affiliation: Department of Polymer Science and Engineering and CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China.
authors.forename: Yu-Cai
authors.initials: YC
authors.lastname: Wang
authors.forename: Juan
authors.initials: J
authors.lastname: Wu
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Jin-Zhi
authors.initials: JZ
authors.lastname: Du
authors.forename: You-Yong
authors.initials: YY
authors.lastname: Yuan
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
mesh_terms: D004317:Doxorubicin / Q000494:pharmacology; D016503:Drug Delivery Systems; D056945:Hep G2 Cells; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010316:Particle Size; D010777:Photochemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D012492:Salts / Q000737:chemistry; D013499:Surface Properties
chemical_list: D020100:Hydrogels; D011108:Polymers; D012492:Salts; D004317:Doxorubicin