Relationship of the polyunsaturated to saturated fatty acid ratio to cardiovascular risk factors and metabolic syndrome in Japanese: the INTERLIPID study.
OBJECTIVE
There have been few studies on the relationships of the dietary polyunsaturated to saturated fatty acid ratio (P/S) to cardiovascular risk factors and metabolic syndrome. We hypothesized that there would be favorable relationships.


METHODS
Metabolic cardiovascular risk factors from dietary nutrient intake were investigated in 1,004 men and women aged 40-59 years from 4 population samples of Japanese. Multiple linear regression analysis was used to examine the relationship of the dietary P/S ratio to the following risk factors: hemoglobin A1c, blood pressure, serum triglycerides, LDL and total cholesterol, and HDL-cholesterol. Adjusted odds ratio of having metabolic syndrome was also calculated.


RESULTS
The dietary P/S ratio was significantly and inversely related to serum total and LDL cholesterol with control for possible confounding variables. We did not find any significant relationship between the P/S ratio and single metabolic risk factors or the prevalence of metabolic syndrome.


CONCLUSIONS
Managing the P/S ratio is important to control serum LDL-cholesterol; however, increasing the P/S ratio may not improve metabolic risk factors. Other countermeasures, such as weight control, greater physical activity, and smoking cessation should be recommended to prevent and control metabolic syndrome.
Guo
Zhao
Z
Department of Health Science, Shiga University of Medical Science, Otsu, Japan. guozhao@belle.shiga-med.ac.jp
Miura
Katsuyuki
K
Turin
Tanvir Chowdhury
TC
Hozawa
Atsushi
A
Okuda
Nagako
N
Okamura
Tomonori
T
Saitoh
Shigeyuki
S
Sakata
Kiyomi
K
Nakagawa
Hideaki
H
Okayama
Akira
A
Yoshita
Katsushi
K
Kadowaki
Takashi
T
Choudhury
Sohel R
SR
Nakamura
Yasuyuki
Y
Rodriguez
Beatriz L
BL
Curb
David J
DJ
Elliott
Paul
P
Stamler
Jeremiah
J
Ueshima
Hirotsugu
H
D000328:Adult; D044466:Asian People; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood / Q000208:ethnology*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage; D005227:Fatty Acids / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000208:ethnology*; D008875:Middle Aged; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D006442:Glycated Hemoglobin; D014280:Triglycerides; C517652:hemoglobin A1c protein, human