title: Anticancer drug development: the grand challenges.
abstract: Despite vast investment in oncology R&D, the translation of research advances into medicines that substantially improve the treatment of many cancers remains frustratingly slow. What are the key challenges in anticancer drug development, and how might they be addressed?
authors.affiliation: Ortho Biotech Oncology Research and Development, 920 Route 202, Raritan, New Jersey 08869, USA. Whait@its.jnj.com
authors.forename: William N
authors.initials: WN
authors.lastname: Hait
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D016503:Drug Delivery Systems; D015195:Drug Design; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D007880:Legislation, Drug; D009369:Neoplasms / Q000188:drug therapy* / Q000503:physiopathology; D057285:Precision Medicine; D012106:Research
chemical_list: D000970:Antineoplastic Agents