Comparison of the incidence of imidapril and enalapril induced cough.
BACKGROUND
Imidapril is an angiotensin converting enzyme (ACE) inhibitor without a sulfhydril group which has been shown from previous study to have low incidence of ACE inhibitor induced cough.


OBJECTIVE
To compare the incidence of cough between two ACE inhibitors, imidapril and enalapril.


METHODS
A comparative cross over study was performed in 119 patients with hypertension or left ventricular dysfunction. Patients were assigned to one of the two treatment groups, either a group receiving imidapril or enalapril for 4 weeks (Period I) and then these same groups were crossed over to receive either enalapril or imidapril for 4 weeks (Period II). The occurrence of cough during treatment was monitored by interviewing the patients.


RESULTS
The incidence of cough was 44 % while on imidapril treatment and 66% while on enalapril treatment (p = 0.0014). The antihypertensive effects of two drugs were not different.


CONCLUSIONS
The incidence of cough was significantly less under imidapril than under enalapril treatment, while there was no difference in the antihypertensive effects between the two ACE inhibitors.
Boonyapisit
Warangkna
W
Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. waran_byps@yahoo.com
Tresukosol
Damras
D
D000284:Administration, Oral; D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D003371:Cough / Q000139:chemically induced*; D018592:Cross-Over Studies; D004656:Enalapril / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology; D048289:Imidazolidines / Q000494:pharmacology* / Q000627:therapeutic use; D015994:Incidence; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy* / Q000453:epidemiology
D000806:Angiotensin-Converting Enzyme Inhibitors; D048289:Imidazolidines; D004656:Enalapril; C065166:imidapril