title: Can animal models of disease reliably inform human studies?
abstract: H. Bart van der Worp and colleagues discuss the controversies and possibilities of translating the results of animal experiments into human clinical trials.
authors.affiliation: Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands. H.B.vanderWorp@umcutrecht.nl
authors.forename: H Bart
authors.initials: HB
authors.lastname: van der Worp
authors.forename: David W
authors.initials: DW
authors.lastname: Howells
authors.forename: Emily S
authors.initials: ES
authors.lastname: Sena
authors.forename: Michelle J
authors.initials: MJ
authors.lastname: Porritt
authors.forename: Sarah
authors.initials: S
authors.lastname: Rewell
authors.forename: Victoria
authors.initials: V
authors.lastname: O'Collins
authors.forename: Malcolm R
authors.initials: MR
authors.lastname: Macleod
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D017594:Publication Bias; D015203:Reproducibility of Results; D057170:Translational Research, Biomedical