title: Brimonidine for glaucoma.
abstract: BACKGROUND
  Brimonidine is a drug used in the management of glaucoma throughout the world and is the most modern alpha(2)-adrenoceptor agonist available. This review comprehensively discusses the use of brimonidine for glaucoma.
  
  
  METHODS
  A historical insight into the development of selective adrenergic glaucoma drugs is given, followed by a description of the mechanisms of action and a discussion of the main clinical trials investigating clinical applications. The safety of brimonidine is evaluated, and our expert opinion is provided on how brimonidine is used in our clinical practice. The most relevant literature on the role of brimonidine in glaucoma is discussed.
  
  
  RESULTS
  A clear understanding of the role of brimonidine for glaucoma treatment, with an explanation of its efficacy, limitations and use in clinical practice.
  
  
  CONCLUSIONS
  Brimonidine is an effective drug for lowering intraocular pressure. It has potentially serious systemic effects in children, in whom it is contraindicated. Its use in adults is limited by its ocular side effects such as allergy. Brimonidine is, however, an important part of the range of intraocular pressure lowering drugs available to prescribers.
authors.affiliation: Gartnavel General Hospital, Tennent Institute of Ophthalmology, Glasgow, UK. mmnrahman@hotmail.com
authors.forename: Mamun Q
authors.initials: MQ
authors.lastname: Rahman
authors.forename: Kanna
authors.initials: K
authors.lastname: Ramaesh
authors.forename: Donald M I
authors.initials: DM
authors.lastname: Montgomery
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000818:Animals; D000959:Antihypertensive Agents / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000068438:Brimonidine Tartrate; D005901:Glaucoma / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects / Q000502:physiology; D011810:Quinoxalines / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D000316:Adrenergic alpha-Agonists; D000959:Antihypertensive Agents; D011810:Quinoxalines; D000068438:Brimonidine Tartrate