Researching genetic versus nongenetic determinants of disease: a comparison and proposed unification.
Research standards deviate in genetic versus nongenetic epidemiology. Besides some immutable differences, such as the correlation pattern between variables, these divergent research standards can converge considerably. Current research designs that dissociate genetic and nongenetic measurements are reaching their limits. Studies are needed that massively measure genotypes, nongenetic exposures, and outcomes concurrently.
Ioannidis
John P A
JP
Clinical and Molecular Epidemiology Unit, Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece. jioannid@cc.uoi.gr
Loy
En Yun
EY
Poulton
Richie
R
Chia
Kee Seng
KS
D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D008957:Models, Genetic