New approaches to the total synthesis of the bryostatin antitumor macrolides.
In this Focus Review, we give an overview of various bryostatin total syntheses. We also discuss the synthesis of various bryostatin analogues and their biological activity. Work reviewed includes that of Masamune, Evans, Nishiyama and Yamamura, Hale and Manaviazar, Trost, Wender, Keck, Burke, Thomas, and Krische. Our coverage is primarily for the period 2001-2009, since detailed reviews already exist on bryostatin total synthesis work and biology up to this time.
Hale
Karl J
KJ
School of Chemistry & Chemical Engineering, Queen's Universty Belfast, Stranmillis Road, Belfast BT9 5AG, Northern Ireland, UK. k.j.hale@qub.ac.uk
Manaviazar
Soraya
S
D000544:Alzheimer Disease / Q000188:drug therapy; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D054713:Bryostatins / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism
D000970:Antineoplastic Agents; D054713:Bryostatins; D011493:Protein Kinase C