Genetically modified mesenchymal stem cells and their clinical potential in acute cardiovascular disease.
Adult mesenchymal stem cells (MSCs) are non-hematopoietic cells with multi-lineage potential to differentiate into various tissues of mesodermal origin. They can be isolated from bone marrow and other tissues and have the capacity to extensively proliferate in vitro. Moreover, MSCs have also been shown to produce anti-inflammatory molecules which can modulate humoral and cellular immune responses. Considering their regenerative potential and immunoregulatory effect, MSC therapy is a promising tool in the treatment of degenerative, inflammatory, and autoimmune diseases. However, the current understanding from results of clinical trials is that MSC-therapy is safe but its therapeutic efficiency needs to be improved. In this article we will focus on options for genetic manipulation of MSCs and on current progress in adapting genetically-modified MSCs for clinical use in acute cardiovascular disease.
Griffin
Matthew
M
College of Medicine, Nursing and Health Sciences and Regenerative Medicine Institute, National Centre for Biomedical Engineering Science, National University of Ireland, Galway, Ireland.
Greiser
Udo
U
Barry
Frank
F
O'Brien
Timothy
T
Ritter
Thomas
T
D000208:Acute Disease; D000818:Animals; D002318:Cardiovascular Diseases / Q000628:therapy*; D002469:Cell Separation; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D006801:Humans; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000378:metabolism*