Fingered for a fat fate.
Differentiation of preadipocytes to adipocytes is controlled by the nuclear receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but little is known about earlier transcriptional events in mesenchymal stem cells that define the adipocyte lineage. A recent report (Gupta et al., 2010) identifies the zinc finger protein Zfp423 as a determining factor in preadipocyte commitment.
Schupp
Michael
M
Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, The Institute for Diabetes, Obesity, and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Lazar
Mitchell A
MA
D017667:Adipocytes / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D047495:PPAR gamma / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
D004268:DNA-Binding Proteins; C484557:Ebfaz protein, mouse; D047495:PPAR gamma; D014157:Transcription Factors