title: Effect of prenylated flavonoids and chalcones isolated from Artocarpus species on platelet aggregation in human whole blood.
abstract: Five prenylflavonoids and two prenylchalcones from Artocarpus lowii King, A. scortechinii King and A. teysmanii Miq., and acetylated derivatives of cycloheterophyllin and artonin E were investigated for their ability to inhibit arachidonic acid (AA), collagen and adenosine diphosphate (ADP)-induced platelet aggregation in human whole blood by using an electrical impedance method. Among the tested compounds, only cycloheterophyllin inhibited AA-induced platelet aggregation with an IC(50) value of 100.9 microM. It also showed strong inhibition against ADP-induced aggregation, with an IC(50) value of 57.1 microM. Isobavachalcone, 2',4'-dihydroxy-4-methoxy-3'-prenyldihydrochalcone, cycloartobiloxanthone, artonin E and artonin E triacetate showed selective inhibition against ADP-induced aggregation, with IC(50) values ranging from 55.3 to 192.0 microM, but did not show such effect against other inducers.
authors.affiliation: Faculty of Pharmacy, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia. ibj@pharmacy.ukm.my
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Jantan
authors.forename: Yusyila H
authors.initials: YH
authors.lastname: Mohd Yasin
authors.forename: Shajarahtunnur
authors.initials: S
authors.lastname: Jamil
authors.forename: Hasnah
authors.initials: H
authors.lastname: Sirat
authors.forename: Norazah
authors.initials: N
authors.lastname: Basar
mesh_terms: D031622:Artocarpus / Q000737:chemistry*; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D010974:Platelet Aggregation / Q000187:drug effects*
chemical_list: D047188:Chalcones; D005419:Flavonoids