title: Gabapentin does not reduce preoperative anxiety when given prior to total hip arthroplasty.
abstract: BACKGROUND
  Gabapentin is an anti-epileptic drug which is also used for the treatment of postoperative pain and a variety of psychiatric diseases including chronic anxiety disorders. We tested the hypothesis that compared with a placebo control, gabapentin would reduce preoperative anxiety in patients undergoing total hip arthroplasty.
  
  
  METHODS
  Following ethics approval, patients participating in a larger double blind, randomized, trial of multimodal analgesia were given either gabapentin 600 mg (N = 22) or placebo (N = 48) 2 hours before spinal anesthesia. Prior to administering the study medication, baseline anxiety levels were measured using a visual analog scale (VAS). Two hours after the ingestion of gabapentin or placebo, and prior to surgery, patients again rated their anxiety using a VAS.
  
  
  RESULTS
  Anxiety scores did not differ significantly between the groups either before (P = 0.95) or 2 hours after (P = 0.61) ingestion of gabapentin or placebo. Baseline anxiety and postdrug anxiety scores failed to demonstrate a significant association with maximal postoperative pain at rest, maximal postoperative pain with movement, and cumulative morphine consumption 48 hours after surgery.
  
  
  CONCLUSIONS
  Administration of gabapentin 600 mg prior to surgery does not reduce preoperative anxiety.
authors.affiliation: Department of Anesthesia and Pain Management, Toronto General Hospital, Toronto, Ontario, Canada. hance.clarke@utoronto.ca
authors.forename: Hance
authors.initials: H
authors.lastname: Clarke
authors.forename: Joseph
authors.initials: J
authors.lastname: Kay
authors.forename: Beverley A
authors.initials: BA
authors.lastname: Orser
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Gollish
authors.forename: Nicholas
authors.initials: N
authors.lastname: Mitsakakis
authors.forename: Joel
authors.initials: J
authors.lastname: Katz
mesh_terms: D000368:Aged; D000588:Amines / Q000627:therapeutic use*; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy* / Q000209:etiology; D019644:Arthroplasty, Replacement, Hip / Q000523:psychology*; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D000077206:Gabapentin; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos / Q000627:therapeutic use; D057234:Preoperative Period; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid / Q000627:therapeutic use*
chemical_list: D000588:Amines; D014151:Anti-Anxiety Agents; D003509:Cyclohexanecarboxylic Acids; D010919:Placebos; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin