Gastrin: an acid-releasing, proliferative and immunomodulatory peptide?
Gastrin release is affected by gastric inflammatory conditions. Antral G cells respond to inflammatory mediators by increasing gastrin secretion. Accumulating experimental evidence suggests that gastrin exerts immunomodulatory and proinflammatory effects. Gastrin could be a contributing factor to these pathologies, which may constitute a new justification for pharmacological blockade of gastrin action.
Calatayud
Sara
S
Departamento de Farmacología and CIBERehd, Facultad de Medicina, Universidad de Valencia, Avd. Blasco Ibáñez 15, Valencia, Spain. sara.calatayud@uv.es
Alvarez
Angeles
A
Víctor
Víctor M
VM
D000818:Animals; D049109:Cell Proliferation; D005744:Gastric Acid / Q000378:metabolism*; D019863:Gastrin-Secreting Cells / Q000187:drug effects / Q000502:physiology; D015408:Gastrinoma / Q000503:physiopathology; D005755:Gastrins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005756:Gastritis / Q000503:physiopathology; D006801:Humans; D056747:Immunomodulation; D011498:Protein Precursors / Q000235:genetics / Q000378:metabolism; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors / Q000502:physiology; D015398:Signal Transduction
D005755:Gastrins; D011498:Protein Precursors; D011949:Receptors, Cholecystokinin; C042873:preprogastrin