title: [Primary aspergillus laryngitis: report of six cases].
abstract: OBJECTIVE
  To discuss the distinctive clinical manifestation of primary aspergillus laryngitis.
  
  
  METHODS
  Six cases of primary aspergillus laryngitis in our department were reviewed, among which 3 cases were diabetes patients, and were laryngeal mucosal barrier impairment. 2 cases were smoking, 2 cases were over use of voice and 1 case was gastro-pharyngeal reflux. Refractory hoarseness was the main clinical manifestation of all patients. The prophase treatment with antibiotics and glucocorticoid should breakdown the balance of flora and exacerbate the disease.
  
  
  RESULTS
  Stop using antibiotics and glucocorticoid and alter to oral administration of itraconazole in 2 to 4 weeks after final diagnosis can effectively cure the disease. No recurrence was found in 6 month to 4 years follow up.
  
  
  CONCLUSIONS
  Diffuse hyperemia, pachynsis and scattered lamellar leukasmus of vocal cord were the characteristic physical findings of primary aspergillus laryngitis. Pathology is the major means to get the final diagnosis. Oral administration of itraconazole could be effective.
authors.affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, the Second Affiliated Hospital of Shantou University, Shantou, 515000, China. gdhfcrh@yahoo.com.cn
authors.forename: Renhui
authors.initials: R
authors.lastname: Chen
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Zhuohua
authors.initials: Z
authors.lastname: Yao
mesh_terms: D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000175:diagnosis / Q000188:drug therapy; D001230:Aspergillus; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D007827:Laryngitis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole