title: Acidic pH-responsive nanogels as smart cargo systems for the simultaneous loading and release of short oligonucleotides and magnetic nanoparticles.
abstract: Smart materials able to sense environmental stimuli can be exploited as intelligent carrier systems. Acidic pH-responsive polymers, for instance, exhibit a variation in the ionization state upon lowering the pH, which leads to their swelling. The different permeability of these polymers as a function of the pH could be exploited for the incorporation and subsequent release of previously trapped payload molecules/nanoparticles. We provide here a proof of concept of a novel use of pH-responsive polymer nanostructures based on 2-vinylpyridine and divinylbenzene, having an overall size below 200 nm, as cargo system for magnetic nanoparticles, for oligonucleotide sequences, as well as for their simultaneous loading and controlled release mediated by the pH.
authors.affiliation: Istituto Italiano di Tecnologia, via Morego 30, 16163, Genova, Italy.
authors.forename: Smriti R
authors.initials: SR
authors.lastname: Deka
authors.forename: Alessandra
authors.initials: A
authors.lastname: Quarta
authors.forename: Riccardo
authors.initials: R
authors.lastname: Di Corato
authors.forename: Andrea
authors.initials: A
authors.lastname: Falqui
authors.forename: Liberato
authors.initials: L
authors.lastname: Manna
authors.forename: Roberto
authors.initials: R
authors.lastname: Cingolani
authors.forename: Teresa
authors.initials: T
authors.lastname: Pellegrino
mesh_terms: D004337:Drug Carriers / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008280:Magnetics; D000080385:Nanogels; D053758:Nanoparticles / Q000737:chemistry; D009841:Oligonucleotides / Q000737:chemistry* / Q000378:metabolism; D010539:Permeability; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000493:pharmacokinetics; D011094:Polyethyleneimine / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D004337:Drug Carriers; D000080385:Nanogels; D009841:Oligonucleotides; C413692:polyethylene glycol polyethyleneimine nanogel; D011092:Polyethylene Glycols; D011094:Polyethyleneimine