The role of heart-type fatty acid-binding protein in the evaluation of carbon monoxide poisoning in rats.
Acute carbon monoxide (CO) poisoning can cause early and persistent damages in tissues sensitive to hypoxia. This study investigated serum heart-type fatty acid-binding protein (H-FABP) levels as a biomarker of acute CO poisoning in rats. The rats were exposed to a mixture of either 3000 (group A) or 5000 (group B) parts per million (ppm) CO in air, or to ambient air (group C, control group). Blood samples were taken just before, immediately after and 6 hours after the exposure, and serum H-FABP and troponin-I levels were measured. The consciousness level was evaluated just after the exposure. The survival rate was monitored for 7 days. Serum H-FABP levels increased just after the CO exposure in both groups A and B. Additionally, H-FABP level was higher in group B than in group A, immediately after the exposure. However, serum troponin-I levels only increased at 6 hours after the CO exposure in groups A and B. Consciousness and survival rates in group B were lower than that in group A. Our results suggest that H-FABP might have potential to be an early and quantitative parameter of clinical severity and prognosis in CO poisoning.
Yardan
Turker
T
Department of Emergency Medicine, School of Medicine, Ondokuz Mayis University, Samsun, Turkey. tyardan@yahoo.com
Meric
Murat
M
Bozkurt
Ayhan
A
Bilge
Sirri
S
Bas
Duygu Belkis
DB
Bedir
Abdulkerim
A
Ozdemir
Tulay
T
Baydin
Ahmet
A
D000818:Animals; D015415:Biomarkers / Q000097:blood; D002249:Carbon Monoxide Poisoning / Q000097:blood* / Q000175:diagnosis; D002263:Carboxyhemoglobin / Q000032:analysis; D004195:Disease Models, Animal; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D008297:Male; D011379:Prognosis; D051381:Rats; D017207:Rats, Sprague-Dawley; D019210:Troponin I / Q000097:blood
D015415:Biomarkers; C509948:FABP3 protein, rat; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D019210:Troponin I; D002263:Carboxyhemoglobin