Synthesis of the C9-C23 (C9'-C23') fragment of the dimeric natural product rhizopodin.
A stereoselective assembly of the C9-C23 (C9'-C23') fragment of rhizopodin, a 38-membered bis-lactone natural product, has been developed. A highly efficient approach to this fragment assembles >50% of the carbon skeleton and the stereochemical elements present in the natural product.
Chen
Zheng
Z
Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School, University Town of Shenzhen, Xili, Nanshan District, Shenzhen, China.
Song
Liankai
L
Xu
Zhengshuang
Z
Ye
Tao
T
D001688:Biological Products / Q000737:chemistry*; D019281:Dimerization; D018942:Macrolides; D010080:Oxazoles / Q000138:chemical synthesis*; D013237:Stereoisomerism
D001688:Biological Products; D018942:Macrolides; D010080:Oxazoles; C081739:rhizopodin