title: A look behind closed doors: interaction of persistent viruses with dendritic cells.
abstract: Persistent infections with HIV, hepatitis B virus and hepatitis C virus are major causes of morbidity and mortality worldwide. As sentinels of the immune system, dendritic cells (DCs) are crucial for the generation of protective antiviral immunity. Recent advances in our understanding of the role of DCs during infection with these viruses provide insights into the mechanisms used by these viruses to exploit DC function and evade innate and adaptive immunity. In this Review we highlight the current knowledge about the interaction between DCs and these viruses and the underlying mechanisms that might influence the outcome of viral infections.
authors.affiliation: Inserm, U748, 3 rue Koeberlé, F-67000 Strasbourg, France.
authors.forename: Mélanie
authors.initials: M
authors.lastname: Lambotin
authors.forename: Sukanya
authors.initials: S
authors.lastname: Raghuraman
authors.forename: Françoise
authors.initials: F
authors.lastname: Stoll-Keller
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Baumert
authors.forename: Heidi
authors.initials: H
authors.lastname: Barth
mesh_terms: D017951:Antigen Presentation; D003713:Dendritic Cells / Q000145:classification / Q000276:immunology* / Q000821:virology*; D006678:HIV / Q000276:immunology* / Q000472:pathogenicity*; D015658:HIV Infections / Q000276:immunology / Q000821:virology; D016174:Hepacivirus / Q000276:immunology* / Q000472:pathogenicity*; D006509:Hepatitis B / Q000276:immunology / Q000821:virology; D006515:Hepatitis B virus / Q000276:immunology* / Q000472:pathogenicity*; D006526:Hepatitis C / Q000276:immunology / Q000821:virology; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D008099:Liver / Q000276:immunology / Q000821:virology; D018448:Models, Immunological