Long term follow-up results of external beam radiotherapy as primary treatment for retinoblastoma.
The authors reviewed their experiences of external beam radiotherapy (EBR) as an initial treatment in retinoblastoma patients to determine its long-term effect on subsequent tumor control and complications. A total of 32 eyes in 25 patients that underwent EBR for retinoblastoma were reviewed retrospectively. The patients consisted of 21 boys and 4 girls of median age at treatment of 7.1 months. Radiation doses ranged from 35 to 59.4 Gy. The 10-yr ocular and patient survivals were 75.4% and 92.3%, respectively. Nine of the 32 eyes progressed; 7 of these were enucleated and 2 were salvaged by focal treatment. According to the Reese-Ellsworth classification, 4 of 5 eyes of Group II, 13 of 16 Group III eyes, 2 of 4 Group IV eyes, and 5 of 7 Group V eyes were retained, and of the 32 eyes, 13 had visual acuity better than 20/200. Eleven patients experienced a radiation-induced complication. No patient developed a second malignancy during follow-up. Despite the limited number of patients enrolled, EBR may provide a mean of preserving eyeball and vision for some advanced lesions.
Choi
Sang Yul
SY
Department of Ophthalmology, Korea Institute of Radiological & Medical Sciences, Seoul, Korea.
Kim
Mi-Sook
MS
Yoo
Sungyul
S
Cho
Chulkoo
C
Ji
YoungHoon
Y
Kim
KumBae
K
Seo
YoungSeok
Y
Park
Kyung Duk
KD
Lee
JunAh
J
Lee
Tai-Won
TW
D002648:Child; D002675:Child, Preschool; D015353:Eye Enucleation; D005260:Female; D006801:Humans; D007223:Infant; D007723:Korea; D008297:Male; D011878:Radiotherapy / Q000379:methods*; D011879:Radiotherapy Dosage; D019572:Retinal Neoplasms / Q000532:radiotherapy*; D012175:Retinoblastoma / Q000532:radiotherapy*; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome