Use of the Diels-Alder adduct of pyrrole in organic synthesis. Formal racemic synthesis of Tamiflu.
A new synthetic route to Tamiflu was developed via the Diels-Alder reaction of pyrrole and bromoacetylene.
Kamimura
Akio
A
Department of Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi University, Ube 755-8611 Japan. ak10@yamaguchi-u.ac.jp
Nakano
Toshiki
T
D000114:Acetylene / Q000031:analogs & derivatives* / Q000737:chemistry*; D000998:Antiviral Agents / Q000138:chemical synthesis*; D015394:Molecular Structure; D053139:Oseltamivir / Q000138:chemical synthesis*; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D011758:Pyrroles; D053139:Oseltamivir; D000114:Acetylene