title: Gamma knife radiosurgery for intracranial cavernous malformations.
abstract: OBJECTIVE
  To analyze and evaluate the role of Gamma knife radiosurgery (GKRS) and clinical outcome in patients with intracranial cavernous malformations.
  
  
  METHODS
  The medical records of 96 patients who underwent radiosurgery at our institute were reviewed retrospectively.
  
  
  RESULTS
  After a mean follow-up period of 4.3 years, 33 cases out of 44 (75.0%) with complaint of seizure had cleared or got improved, 9 (20.5%) were not improved and 2 (4.5%) got worse. Of the 100 lesions in the 96 patients, 24 (24.0%) had the lesions shrinkage on the follow-up imagings. One patient (1.6%) with symptom of headache and dizziness got worse and three patients (3.1%) presented with new cranial nerve palsy. We have compared the treatment results between different marginal dose groups and find that low marginal dose can get better therapeutic efficacy but with less complications.
  
  
  CONCLUSIONS
  GKRS is an effective and microinvasive treatment option for intracranial cavernous malformations.
authors.affiliation: Gamma Knife Center, Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Fangcheng
authors.initials: F
authors.lastname: Zhang
authors.forename: Hongyun
authors.initials: H
authors.lastname: Zhang
authors.forename: Hongyang
authors.initials: H
authors.lastname: Zhao
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001929:Brain Edema / Q000453:epidemiology / Q000209:etiology; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000473:pathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology; D011874:Radiometry; D016634:Radiosurgery / Q000009:adverse effects; D012189:Retrospective Studies; D012306:Risk; D012640:Seizures / Q000209:etiology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D055815:Young Adult