title: Integrated network analysis of transcriptomic and proteomic data in psoriasis.
abstract: BACKGROUND
  Psoriasis is complex inflammatory skin pathology of autoimmune origin. Several cell types are perturbed in this pathology, and underlying signaling events are complex and still poorly understood.
  
  
  RESULTS
  In order to gain insight into molecular machinery underlying the disease, we conducted a comprehensive meta-analysis of proteomics and transcriptomics of psoriatic lesions from independent studies. Network-based analysis revealed similarities in regulation at both proteomics and transcriptomics level. We identified a group of transcription factors responsible for overexpression of psoriasis genes and a number of previously unknown signaling pathways that may play a role in this process. We also evaluated functional synergy between transcriptomics and proteomics results.
  
  
  CONCLUSIONS
  We developed network-based methodology for integrative analysis of high throughput data sets of different types. Investigation of proteomics and transcriptomics data sets on psoriasis revealed versatility in regulatory machinery underlying pathology and showed complementarities between two levels of cellular organization.
authors.affiliation: Vavilov Institute of General Genetics, Russian Academy of Sciences, Gubkina St, 3 GSP-1, 119991 Moscow, Russia.
authors.forename: Eleonora
authors.initials: E
authors.lastname: Piruzian
authors.forename: Sergey
authors.initials: S
authors.lastname: Bruskin
authors.forename: Alex
authors.initials: A
authors.lastname: Ishkin
authors.forename: Rustam
authors.initials: R
authors.lastname: Abdeev
authors.forename: Sergey
authors.initials: S
authors.lastname: Moshkovskii
authors.forename: Stanislav
authors.initials: S
authors.lastname: Melnik
authors.forename: Yuri
authors.initials: Y
authors.lastname: Nikolsky
authors.forename: Tatiana
authors.initials: T
authors.lastname: Nikolskaya
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D007249:Inflammation; D008297:Male; D008957:Models, Genetic; D015233:Models, Statistical; D020411:Oligonucleotide Array Sequence Analysis; D040901:Proteomics / Q000379:methods*; D011565:Psoriasis / Q000378:metabolism*; D012867:Skin / Q000473:pathology; D049490:Systems Biology; D014158:Transcription, Genetic