title: Organocatalyzed enantioselective one-pot three-component access to indoloquinolizidines by a Michael addition-Pictet-Spengler sequence.
abstract: The enantioselective three-component Michael addition-Pictet-Spengler sequence of beta-ketoesters 1, alpha,beta-unsaturated aldehydes 2 and tryptamines 4 represents a facile and rapid one-pot access to highly substituted indoloquinolizidines in moderate to excellent yields and good to excellent enantioselectivities.
authors.affiliation: Department of Chemistry, Shanghai University, 99 Shangda Rd, Shanghai 200444, People's Republic of China. wuxy@shu.edu.cn
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Wu
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Dai
authors.forename: Linlin
authors.initials: L
authors.lastname: Nie
authors.forename: Huihui
authors.initials: H
authors.lastname: Fang
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Zhongjiao
authors.initials: Z
authors.lastname: Ren
authors.forename: Weiguo
authors.initials: W
authors.lastname: Cao
authors.forename: Gang
authors.initials: G
authors.lastname: Zhao
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D009930:Organic Chemicals / Q000737:chemistry; D054837:Quinolizidines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007211:Indoles; D009930:Organic Chemicals; D054837:Quinolizidines