title: Structural dissection of cyclin dependent kinases regulation and protein recognition properties.
abstract: Cyclin Dependent Kinases (CDKs) regulate the cell division cycle, apoptosis, transcription and differentiation in addition to functions in the nervous system. They are regulated by their cyclin partners and by a variety of additional protein effectors (inhibitors, kinases, phosphatases). Each CDK serves its function by means of specific protein recognition properties. These are also responsible for the differential regulation of CDKs/Cyclin couples involved in processes as different as cell cycle and transcription. The structural features determining general and specific properties for CDKs/Cyclin complexes are analyzed. They reside in an overall conserved architecture with divergent spots used by the complexes to present themselves to specific substrates or other protein effectors.
authors.affiliation: Venetian Institute of Molecular Medicine, University of Padua, Padua, Italy. graziano.lolli@unipd.it
authors.forename: Graziano
authors.initials: G
authors.lastname: Lolli
mesh_terms: D001665:Binding Sites; D018844:Cyclin-Dependent Kinases / Q000737:chemistry* / Q000378:metabolism; D016213:Cyclins / Q000737:chemistry / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000737:chemistry; D017434:Protein Structure, Tertiary
chemical_list: D016213:Cyclins; D047428:Protein Kinase Inhibitors; D018844:Cyclin-Dependent Kinases