title: Brown fat uptake of 18F-FDG on dual time point PET/CT imaging.
abstract: The aim of this report was to assess the changes in the 18F-fluorodeoxyglucose (18F-FDG) uptake of brown fats on integrated positron emission tomography/computed tomography (PET/CT) imaging. The patient presented with an enlargement of the neck lymph nodes, and was suspicious for tuberculous lymphadenitis. A whole body PET/CT imaging was performed, followed by a delayed imaging of the neck and thoracic regions. A visually increased 18F-FDG uptake was taken as a positive finding. A semi-quantitative evaluation was performed using a maximum standardised uptake value (SUVmax), with a cut-off value above 2.5. There were a number of 18F-FDG avid activity areas seen at the supraclavicular, mediastinal, paravertebral and perirenal regions. These are in keeping with the physiological 18F-FDG uptake in brown fat. The differences in SUVmax between the two images ranged from -20 percent to +20 percent. Based on our observations, dual time point imaging may not be a reliable method for assessing the 18F-FDG uptake of brown fat.
authors.affiliation: Discipline of Medical Radiations, School of Medical Sciences, Bundoora West Campus, Royal Melbourne Institute of Technology University, Bundoora, Victoria 3083, Australia.
authors.forename: A R
authors.initials: AR
authors.lastname: Hairil Rashmizal
authors.forename: A R
authors.initials: AR
authors.lastname: Noraini
authors.forename: C
authors.initials: C
authors.lastname: Rossetti
authors.forename: N
authors.initials: N
authors.lastname: Abdul Jalil
mesh_terms: D002001:Adipose Tissue, Brown / Q000000981:diagnostic imaging* / Q000378:metabolism; D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*; D014388:Tuberculosis, Lymph Node / Q000000981:diagnostic imaging
chemical_list: D019788:Fluorodeoxyglucose F18