title: Cucurbitane-type triterpenoids from Momordica charantia.
abstract: One new cucurbitane-type triterpenoid glycoside, momordicoside U (1), together with five known cucurbitane-type triterpenoids and related glycosides, 3β,7 β,25-trihydroxycucurbita-5,23 (E)-dien-19-al (2), momordicine I (3), momordicine II (4), 3-hydroxycucurbita-5,24-dien-19-al-7,23-di-O-β-glucopyranoside (5), and kuguaglycoside G (6), were isolated from the whole plant of Momordica charantia. Their structures were determined by chemical and spectroscopic methods. Momordicoside U (1) was evaluated for insulin secretion activity in an in vitro insulin secretion assay and displayed moderate activity.
authors.affiliation: Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U. S. Food and Drug Administration, College Park, MD 20740, USA. jun.ma@fda.hhs.gov
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: Paul
authors.initials: P
authors.lastname: Whittaker
authors.forename: Amy C
authors.initials: AC
authors.lastname: Keller
authors.forename: Eugene P
authors.initials: EP
authors.lastname: Mazzola
authors.forename: Rahul S
authors.initials: RS
authors.lastname: Pawar
authors.forename: Kevin D
authors.initials: KD
authors.lastname: White
authors.forename: John H
authors.initials: JH
authors.lastname: Callahan
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Kennelly
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: Krynitsky
authors.forename: Jeanne I
authors.initials: JI
authors.lastname: Rader
mesh_terms: D000818:Animals; D002460:Cell Line; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000187:drug effects*; D051379:Mice; D029777:Momordica charantia / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D006027:Glycosides; D007328:Insulin; D012503:Saponins; D014315:Triterpenes; C557380:momordicoside U