title: Nanosilicon carbide/hydroxyapatite nanocomposites: structural, mechanical and in vitro cellular properties.
abstract: In this study, bioceramic nanocomposites were synthesized by sintering compacted bodies of hydroxyapatite (HA) mixed with 5 or 15 wt% nanosilicon carbide at 1,100 or 1,200 degrees C in a reducing atmosphere. Pure hydroxyapatite was also prepared for comparison. Phase compositions, structural and physical properties of the composites were studied using appropriate techniques. Some in vitro biological properties of the composites were also investigated by using newrat calvaria osteoblastic cells. X-ray diffraction analysis indicated that tricalcium phosphate (TCP) comprising negligible alpha-TCP and considerable beta-TCP were formed in composites during sintering meanwhile hydroxyapatite and silicon carbide (SiC) were also existed in the composition. Based on the results, that composite made of 5 wt% nanosilicon carbide exhibited higher bending strength, fracture toughness and bulk density than pure HA and composite with 15 wt% silicon carbide. The scanning electron microscopy coupled with energy dispersive X-ray analysis revealed that the addition of nanosilicon carbide suppressed the grain growth and yielded a feature of island-type clusters consisting of blistered calcium phosphate (HA and TCP) and SiC grains. Also, in this study, better proliferation rate and alkaline phosphatase activity were observed for the osteoblastic cells seeded on top of the composites compared to pure HA. Overall, the results indicated that the composite of 95 wt% hydroxyapatite and 5 wt% SiC exhibited better mechanical and biological properties than pure HA and further addition of SiC failed strength and toughness.
authors.affiliation: Department of Ceramics, Materials and Energy Research Center, Tehran, Iran. s-hesaraki@merc.ac.ir
authors.forename: Saeed
authors.initials: S
authors.lastname: Hesaraki
authors.forename: Touraj
authors.initials: T
authors.lastname: Ebadzadeh
authors.forename: Shaghayegh
authors.initials: S
authors.lastname: Ahmadzadeh-Asl
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002130:Calcium Phosphates / Q000737:chemistry*; D017554:Carbon Compounds, Inorganic / Q000494:pharmacology; D017886:Durapatite / Q000737:chemistry*; D053761:Nanocomposites; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D051381:Rats; D017655:Silicon Compounds / Q000494:pharmacology; D012886:Skull / Q000166:cytology; D014961:X-Ray Diffraction; D014965:X-Rays
chemical_list: D002130:Calcium Phosphates; D017554:Carbon Compounds, Inorganic; D017655:Silicon Compounds; C485828:alpha-tricalcium phosphate; C485817:beta-tricalcium phosphate; D017886:Durapatite; C020243:calcium phosphate; C018392:tricalcium phosphate; C022088:silicon carbide