title: Identifications of inhibitors of IgE production by human lymphocytes isolated from 'Cha Chuukanbohon Nou 6' tea leaves.
abstract: BACKGROUND
  Tea (Camellia sinensis L.) is consumed all over the world and in especially large quantities in Japan and China, where it has been used not only as a daily beverage but also for medicinal purposes for thousands of years. Tea has been found to exhibit various bioregulatory activities, including antiallergic, anticarcinogenic, antimetastatic, antioxidative, antihypertensive, antihypercholesterolemic, anti-dental caries and antibacterial effects, and to influence intestinal flora.
  
  
  RESULTS
  Cha Chuukanbohon Nou 6 is a tea cultivar improved by the National Institute of Vegetable and Tea Science (NIVTS) in Japan. On comparing chemical constituents of 11 varieties of tea leaves by high-performance liquid chromatography, we found two new major compounds in Cha Chuukanbohon Nou 6. Nuclear magnetic resonance spectroscopy revealed these compounds to be theogallin and 1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl-beta-D-glucopyranose. The two were similar in chemical structure to strictinin, an inhibitor of immunoglobulin (Ig) production. Thus their effects on the production of Igs by peripheral blood lymphocytes were tested. Both compounds, like strictinin, inhibited IgE production.
  
  
  CONCLUSIONS
  The results suggest Cha Chuukanbohon Nou 6 to be the basis of an antiallergic beverage.
authors.affiliation: Research Laboratory for Health and Gustatory Science, Asahi Breweries Ltd, Ibaraki 302-0106, Japan. daiki.honma@asahibeer.co.jp
authors.forename: Daiki
authors.initials: D
authors.lastname: Honma
authors.forename: Motoyuki
authors.initials: M
authors.lastname: Tagashira
authors.forename: Tomomasa
authors.initials: T
authors.lastname: Kanda
authors.forename: Mari
authors.initials: M
authors.lastname: Maeda-Yamamoto
mesh_terms: D000917:Antibody Formation / Q000187:drug effects; D001769:Blood / Q000276:immunology; D028241:Camellia sinensis / Q000737:chemistry* / Q000235:genetics; D002851:Chromatography, High Pressure Liquid; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005838:Genotype; D006801:Humans; D047348:Hydrolyzable Tannins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D010636:Phenols / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry / Q000235:genetics; D011801:Quinic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D013662:Tea / Q000737:chemistry
chemical_list: C552503:1,2-di-O-galloyl-4,6-O-(S)-hexahydroxydiphenoyl-beta-D-glucopyranose; D047348:Hydrolyzable Tannins; D007166:Immunosuppressive Agents; D010636:Phenols; D010936:Plant Extracts; D013662:Tea; C496786:strictinin; C523582:theogallin; D011801:Quinic Acid; D007073:Immunoglobulin E; D005707:Gallic Acid