Palladium-catalyzed asymmetric addition of diarylphosphines to enones toward the synthesis of chiral phosphines.
An asymmetric addition of diarylphosphines to beta-substituted enones under mild conditions using a chiral pincer-palladium catalyst has been developed for the synthesis of chiral phosphines with excellent stereoselectivity (up to 99% ee).
Feng
Jian-Jun
JJ
School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
Chen
Xue-Feng
XF
Shi
Min
M
Duan
Wei-Liang
WL