title: Laryngeal squamous cell carcinoma with knee and heel skin metastases: a case report.
abstract: Distant metastases from laryngeal carcinoma are frequently seen in the lung, bone and liver, while skin metastases are rarely observed. In these cases presented as case reports in the literature, the supradiaphragmatic region is usually involved. Skin metastasis in lower extremity has only been reported in a few cases. While being an indicator of poor prognosis, skin metastasis is also considered as a messenger of distant organ metastasis. Survival is very short after development of skin metastasis. In our case, nodular skin metastasis was found both in the superior-lateral margin of the left patella and in the right heel. This is the first case reported in the literature on laryngeal carcinoma metastasizing to these localizations.
authors.affiliation: Department of Medical Oncology, School of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.
authors.forename: Halil
authors.initials: H
authors.lastname: Kavgaci
authors.forename: Bulent
authors.initials: B
authors.lastname: Yildiz
authors.forename: Umit
authors.initials: U
authors.lastname: Cobanoglu
authors.forename: Evren
authors.initials: E
authors.lastname: Fidan
authors.forename: Feyyaz
authors.initials: F
authors.lastname: Ozdemir
authors.forename: Fazil
authors.initials: F
authors.lastname: Aydin
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000556:secondary*; D017809:Fatal Outcome; D006365:Heel; D006801:Humans; D007717:Knee; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000628:therapy; D008297:Male; D012878:Skin Neoplasms / Q000175:diagnosis / Q000556:secondary*