title: Carbamoylation of aryl halides by molybdenum or tungsten carbonyl amine complexes.
abstract: When aryl halide is treated with molybdenum carbonyl amine complex in the presence of base, carbamoylation proceeds to give amide in good yield. The proposed mechanism involves oxidative addition of aryl halide to molybdenum(0) complex, migratory insertion to carbon monoxide giving acyl(amino)molybdenum(II) or aryl(carbamoyl)molybdenum(II) intermediate, and reductive elimination of the amide. This method is simple and provides an alternative method to the conventional palladium-catalyzed amide formation using gaseous carbon monoxide.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
authors.forename: Wei
authors.initials: W
authors.lastname: Ren
authors.forename: Motoki
authors.initials: M
authors.lastname: Yamane
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D000588:Amines / Q000737:chemistry; D002248:Carbon Monoxide / Q000737:chemistry; D002384:Catalysis; D006219:Halogens / Q000737:chemistry*; D015394:Molecular Structure; D008982:Molybdenum / Q000737:chemistry*; D010084:Oxidation-Reduction; D014414:Tungsten / Q000737:chemistry*
chemical_list: D000577:Amides; D000588:Amines; D006219:Halogens; D002248:Carbon Monoxide; D008982:Molybdenum; D014414:Tungsten