Nuclear transport and the mitotic apparatus: an evolving relationship.
The trafficking of macromolecules between the cytoplasm and the nucleus is controlled by the nuclear pore complexes (NPCs) and various transport factors that facilitate the movement of cargos through the NPCs and their accumulation in the target compartment. While their functions in transport are well established, an ever-growing number of observations have also linked components of the nuclear transport machinery to processes that control chromosome segregation during mitosis, including spindle assembly, kinetochore function, and the spindle assembly checkpoint. In this review, we will discuss this evolving area of study and emerging hypotheses that propose key roles for components of the nuclear transport apparatus in mitotic progression.
Wozniak
Richard
R
Department of Cell Biology, University of Alberta, Edmonton, AB, T6G 2H7, Canada. rick.wozniak@ualberta.ca
Burke
Brian
B
Doye
Valérie
V
D021581:Active Transport, Cell Nucleus; D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D018386:Kinetochores / Q000378:metabolism; D008938:Mitosis; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism; D008941:Spindle Apparatus / Q000502:physiology*
D018797:Cell Cycle Proteins; D028861:Nuclear Pore Complex Proteins