Engineering nanoscopic hydrogels via photo-crosslinking salt-induced polymer assembly for targeted drug delivery.
We report the preparation of biodegradable nanoscopic hydrogels and their application for targeted drug delivery. The nanogel is synthesized in a template-free method by photo-crosslinking salt-induced polymer assemblies. With convenient incorporation of targeted lactosyl moieties, the nanogels efficiently deliver doxorubicin to HepG2 cells through receptor-mediated internalization.
Wang
Yu-Cai
YC
Department of Polymer Science and Engineering and CAS Key Laboratory of Soft Matter Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China.
Wu
Juan
J
Li
Yang
Y
Du
Jin-Zhi
JZ
Yuan
You-Yong
YY
Wang
Jun
J
D004317:Doxorubicin / Q000494:pharmacology; D016503:Drug Delivery Systems; D056945:Hep G2 Cells; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010316:Particle Size; D010777:Photochemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D012492:Salts / Q000737:chemistry; D013499:Surface Properties
D020100:Hydrogels; D011108:Polymers; D012492:Salts; D004317:Doxorubicin