title: Association of -308G/A polymorphism in the tumor necrosis factor-alpha gene promoter with susceptibility to development of hantavirus cardiopulmonary syndrome in the Ribeirão Preto region, Brazil.
abstract: Activation of the immune response in hantavirus cardiopulmonary syndrome (HCPS) leads to a high TNF production, probably contributing to the disease. The polymorphic TNF2 allele (TNF -308G/A) has been associated with increased cytokine production. We investigated the association of the TNF2 allele with the outcome of hantavirus infection in Brazilian patients. A total of 122 hantavirus-exposed individuals (26 presenting HCPS and 96 only hantavirus seroconversion) were studied. The TNF2 allele was more frequently found in HCPS patients than in individuals with positive serology for hantavirus but without a history of HCPS illness, suggesting that the TNF2 allele could represent a risk factor for developing HCPS.
authors.affiliation: Virology Research Center, School of Medicine of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto, SP, Brazil.
authors.forename: Alessandra Abel
authors.initials: AA
authors.lastname: Borges
authors.forename: Eduardo Antônio
authors.initials: EA
authors.lastname: Donadi
authors.forename: Gelse Mazzoni
authors.initials: GM
authors.lastname: Campos
authors.forename: Marcos Lázaro
authors.initials: ML
authors.lastname: Moreli
authors.forename: Ricardo Luiz Moro
authors.initials: RL
authors.lastname: de Sousa
authors.forename: Fabiano Pinto
authors.initials: FP
authors.lastname: Saggioro
authors.forename: Glauciane Garcia
authors.initials: GG
authors.lastname: de Figueiredo
authors.forename: Soraya Jabur
authors.initials: SJ
authors.lastname: Badra
authors.forename: Neifi Hassan Saloum
authors.initials: NH
authors.lastname: Deghaide
authors.forename: Luiz Tadeu Moraes
authors.initials: LT
authors.lastname: Figueiredo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001938:Brazil; D005260:Female; D020022:Genetic Predisposition to Disease; D018778:Hantavirus Infections / Q000235:genetics* / Q000821:virology; D018804:Hantavirus Pulmonary Syndrome / Q000235:genetics* / Q000821:virology; D006331:Heart Diseases / Q000235:genetics* / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D013577:Syndrome; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*; D055815:Young Adult
chemical_list: D014409:Tumor Necrosis Factor-alpha