Cucurbitane-type triterpenoids from Momordica charantia.
One new cucurbitane-type triterpenoid glycoside, momordicoside U (1), together with five known cucurbitane-type triterpenoids and related glycosides, 3β,7 β,25-trihydroxycucurbita-5,23 (E)-dien-19-al (2), momordicine I (3), momordicine II (4), 3-hydroxycucurbita-5,24-dien-19-al-7,23-di-O-β-glucopyranoside (5), and kuguaglycoside G (6), were isolated from the whole plant of Momordica charantia. Their structures were determined by chemical and spectroscopic methods. Momordicoside U (1) was evaluated for insulin secretion activity in an in vitro insulin secretion assay and displayed moderate activity.
Ma
Jun
J
Office of Regulatory Science, Center for Food Safety and Applied Nutrition, U. S. Food and Drug Administration, College Park, MD 20740, USA. jun.ma@fda.hhs.gov
Whittaker
Paul
P
Keller
Amy C
AC
Mazzola
Eugene P
EP
Pawar
Rahul S
RS
White
Kevin D
KD
Callahan
John H
JH
Kennelly
Edward J
EJ
Krynitsky
Alexander J
AJ
Rader
Jeanne I
JI
D000818:Animals; D002460:Cell Line; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D050417:Insulin-Secreting Cells / Q000187:drug effects*; D051379:Mice; D029777:Momordica charantia / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D006027:Glycosides; D007328:Insulin; D012503:Saponins; D014315:Triterpenes; C557380:momordicoside U