Voluntary exercise increases oligodendrogenesis in spinal cord.
Exercise has been shown to increase hippocampal neurogenesis, but the effects of exercise on oligodendrocyte generation have not yet been reported. In this study, we evaluated the hypothesis that voluntary exercise may affect neurogenesis, and more in particular, oligodendrogenesis in the thoracic segment of the intact spinal cord of adult nestin-GFP transgenic mice. Voluntary exercise for 7 and 14 days increased nestin-GFP expression around the ependymal area. In addition, voluntary exercise for 7 days significantly increased nestin-GFP expression in both the white and gray matter of the thoracic segment of the intact spinal cord, whereas, 14-day exercise decreased nestin-GFP expression. Markers for immature oligodendrocytes (transferrin and CNPase) were significantly increased after 7 days of voluntary exercise. These results suggest that voluntary exercise positively influences oligodendrogenesis in the intact spinal cord, emphasizing the beneficial effects of voluntary exercise as a possible co-treatment for spinal cord injury.
Krityakiarana
W
W
Intellectual and Developmental Disability Research Center, Semel Institute for Neuroscience and Human Behavior Department of Neurobiology, David Geffen, School of Medicine at UCLA, Los Angeles, California 90095, USA.
Espinosa-Jeffrey
A
A
Ghiani
C A
CA
Zhao
P M
PM
Topaldjikian
N
N
Gomez-Pinilla
F
F
Yamaguchi
M
M
Kotchabhakdi
N
N
de Vellis
J
J
D000704:Analysis of Variance; D000818:Animals; D002452:Cell Count / Q000379:methods; D005786:Gene Expression Regulation / Q000502:physiology; D049452:Green Fluorescent Proteins / Q000235:genetics; D007381:Intermediate Filament Proteins / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D064231:Nestin; D055495:Neurogenesis / Q000502:physiology*; D009836:Oligodendroglia / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000379:methods*; D013116:Spinal Cord / Q000166:cytology* / Q000502:physiology; D013997:Time Factors
D007381:Intermediate Filament Proteins; C577484:NES protein, human; D009419:Nerve Tissue Proteins; C577485:Nes protein, mouse; D064231:Nestin; D049452:Green Fluorescent Proteins