title: Chiral phosphoric acid catalyzed addition of dihydropyrans to N-acyl imines: stereocontrolled access to enantioenriched spirocyclic oxazoletetrahydropyrans with three contiguous stereocenters.
abstract: Dihydropyran derivatives readily undergo addition to N-acyl imines in the presence of chiral phosphoric acids. This addition process yields an attractive product that is capable of a tandem oxidative-cyclization via an epoxide intermediate.
authors.affiliation: Department of Chemistry, University of South Florida, 4202 East Fowler Avenue CHE205A, Tampa, Florida 33620, USA.
authors.forename: Guilong
authors.initials: G
authors.lastname: Li
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Kaplan
authors.forename: Lukasz
authors.initials: L
authors.lastname: Wojtas
authors.forename: Jon C
authors.initials: JC
authors.lastname: Antilla
mesh_terms: D002384:Catalysis; D008958:Models, Molecular; D010756:Phosphoric Acids / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D010756:Phosphoric Acids; D011714:Pyrans; C030242:phosphoric acid