title: [Expression of CD23 and CD19 on peripheral blood lymphocytes and its association with serum total IgE in patients with allergic rhinitis].
abstract: OBJECTIVE
  To explore the expression of CD23, CD19 on peripheral blood lymphocytes as well as its association with serum total IgE levels and nasal allergic symptoms in patients with allergic rhinitis (AR).
  
  
  METHODS
  Symptom scores were evaluated in 46 AR patients, expression of CD23, CD19 on peripheral blood lymphocytes were measured by flow cytometry, and serum total IgE levels were determined by immune chemiluminescence. Thirty two healthy individuals were enrolled as controls.
  
  
  RESULTS
  The percentage of CD23+, CD19+ and CD23+/ CD19+,on peripheral blood lymphocytes in AR patients were 11.6 +/- 1. , 22.8 +/- 3.3,10.2 +/- 1.7, respectively. Higher frequencies of CD23+, CD19+, and CD23+/CD19+ were found in AR patients compared with controls (P < 0.05). There were positive correlations between expression rates of CD23+, CD19+, CD23+/CD19+ and levels of serum total IgE, nasal allergic symptom scores, respectively. CD23+/CD19+ demonstrated greater correlations with serum total IgE and nasal allergic symptom (r = 0.65 and 0.49, P < 0.05) than CD23+ and CD19+ did. Correlation between CD23+/CD19+ and nasal allergic symptom scores was greater than the corresponding correlations of serum total IgE (r = 0.33, P < 0.05).
  
  
  CONCLUSIONS
  CD23 and CD19 are important factors that associated with serum total IgE in the pathogenesis of AR, Analysis on the expression of CD23+/CD19+ on peripheral blood lymphocytes is helpful for evaluating the severity of AR.
authors.affiliation: Department of Otorhinolaryngology, Taizhou Hospital of Zhejiang Province, Linhai, 317000, China. gtliangent@hotmail.com
authors.forename: Gengtian
authors.initials: G
authors.lastname: Liang
authors.forename: Guangbin
authors.initials: G
authors.lastname: Sun
authors.forename: Zhaohu
authors.initials: Z
authors.lastname: Pan
authors.forename: Zheng
authors.initials: Z
authors.lastname: Liu
authors.forename: Yonghua
authors.initials: Y
authors.lastname: Cui
mesh_terms: D000293:Adolescent; D000328:Adult; D018941:Antigens, CD19 / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000378:metabolism; D008875:Middle Aged; D017455:Receptors, IgE / Q000097:blood*; D012221:Rhinitis, Allergic, Perennial / Q000097:blood*; D055815:Young Adult
chemical_list: D018941:Antigens, CD19; D017455:Receptors, IgE; D007073:Immunoglobulin E