[Difficulties in determining of the equivalent doses of inhaled glucocorticoids].
Inhaled glucocorticoids are the most effective anti-inflammatory medicines used to treat asthma. Determination of equivalent dose is important, because different preparations vary in potency and bioavailability. Despite the large knowledge about the effect of inhaled glucocorticoids the data of their dosing are not consistent and continue to be verified in clinical studies. The authors discuss some of the indicators of pharmacodynamic and pharmacokinetic properties that may help determine the effectiveness, safety and equivalence of different doses of inhaled corticosteroids.
Grzanka
Alicja
A
Slaski Uniwersytet Medyczny w Katowicach, Katedra i Oddział Kliniczny Chorób Wewngtrznych, Dermatologii i Alergologii w Zabrzu. alicjag@mp.pl
Jarzab
Jerzy
J
D000280:Administration, Inhalation; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D001249:Asthma / Q000188:drug therapy; D001682:Biological Availability; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D006801:Humans; D008168:Lung / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids