title: [Development of an extended immunological system parameters for assessment influence of environmental factors on the population's health status].
abstract: The immune status of Moscow dwellers was studied. The findings indicate the criterion significance of immunological and allergological parameters in the estimation of a risk of allergic diseases under the influence of poor environmental factors influence. Hyperactivity in individuals with high immunoglobulin class E levels to environmental factors is suggested by the elevated concentrations of serum specific IgE to intrahouse factors that in combination with the increased levels of anti-inflammatory cytokines (interferon-gamma, tumor necrosis factor-alpha) and the suppressed production interleukin-4 are criteria for the early manifestations of allergy.
authors.forename: A K
authors.initials: AK
authors.lastname: Makovetskaia
authors.forename: V N
authors.initials: VN
authors.lastname: Fedoseeva
authors.forename: O V
authors.initials: OV
authors.lastname: Mislavskiĭ
mesh_terms: D016207:Cytokines / Q000097:blood* / Q000276:immunology; D004781:Environmental Exposure / Q000009:adverse effects*; D006304:Health Status; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D007107:Immune System / Q000378:metabolism*; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology; D009031:Moscow / Q000453:epidemiology; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors; D014505:Urban Population
chemical_list: D016207:Cytokines; D007073:Immunoglobulin E