An anti-influenza component of the bark of Alnus japonica.
This study to identify anti-influenza components of the bark of Alnus japonica resulted in the isolation of four lupane-type triterpenes (1-4) and one steroid (5). Their structures were characterized on the basis of physicochemical properties, NMR evidence, and ESI-MS data compared with reported data in the literature. Betulinic aldehyde (3) exhibited a particularly strong anti-influenza effect against KBNP-0028 relative to a positive control.
Tung
Nguyen Huu
NH
College of Pharmacy, Chungnam National University, Daejeon, 305-764, Korea.
Kwon
Hyuk-Joon
HJ
Kim
Jae-Hong
JH
Ra
Jeong Chan
JC
Kim
Jeong Ah
JA
Kim
Young Ho
YH
D029661:Alnus / Q000737:chemistry; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology; D053127:Influenza A Virus, H9N2 Subtype / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes / Q000494:pharmacology; D024301:Plant Bark; D012855:Sitosterols / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D000094062:Betulinic Acid; D000094042:Lupanes
D000998:Antiviral Agents; D053978:Pentacyclic Triterpenes; D012855:Sitosterols; D013256:Steroids; D014315:Triterpenes; C025473:gamma-sitosterol; C002503:betulin; D000094062:Betulinic Acid; C010480:lupeol; D000094042:Lupanes