Cytotoxicity against KB and NCI-H187 cell lines of modified flavonoids from Kaempferia parviflora.
Flavones 1-4 isolated from Kaempferia parviflora were used for structural modification. Sixteen flavonoid derivatives, including four new derivatives, were synthesized and evaluated for cytotoxicity against KB and NCI-H187 cell lines. Flavanones 2a-4a demonstrated higher cytotoxic activity than the parent compounds. Cytotoxicity against KB cell line of oxime 1c was about 7 times higher than the ellipticine standard. Interestingly, oximes 1c and 2c exhibited highly potent cytotoxicity against NCI-H187 cell line with IC(50) values of 0.014 and 0.23 microM, respectively. Oximes 4c and 5c showed strong cytotoxicity against NCI-H187 cell line with IC(50) values of 4.04 and 2.32 microM, respectively.
Yenjai
Chavi
C
Natural Products Research Unit, Center for Innovation in Chemistry, Department of Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. chayen@kku.ac.th
Wanich
Suchana
S
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D010091:Oximes / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D030521:Zingiberaceae / Q000737:chemistry*
D000970:Antineoplastic Agents; D001578:Benzopyrans; D005419:Flavonoids; D010091:Oximes