title: Pertussis disease burden in the household: how to protect young infants.
abstract: BACKGROUND
  We conducted a population-based, nation-wide, prospective study to identify who introduced pertussis into the household of infants aged 6 months admitted to the hospital for pertussis in the Netherlands.
  
  
  METHODS
  During the period 2006-2008, a total of 560 household contacts of 164 hospitalized infants were tested by polymerase chain reaction, culture, and serological examination to establish Bordetella pertussis infection. Clinical symptoms and vaccination history were obtained by a questionnaire submitted during sample collection and 4-6 weeks afterwards.
  
  
  RESULTS
  Overall, 299 household contacts (53%) had laboratory-confired pertussis; 159 (53%) had symptoms compatible with typical pertussis infection, and 42 (14%) had no symptoms. Among children vaccinated with a whole-cell vaccine, 17 (46%) of 37 had typical pertussis 1-3 years after completion of the primary series, compared with 9 (29%) of 31 children who had been completely vaccinated with an acellular vaccine. For 96 households (60%), the most likely source of infection of the infant was established, being a sibling (41%), mother (38%), or father (17%).
  
  
  CONCLUSIONS
  If immunity to pertussis in parents is maintained or boosted, 35%-55% of infant cases could be prevented. Furthermore, we found that, 1-3 years after vaccination with whole-cell or acellular vaccine, a significant percentage of children are again susceptible for typical pertussis. In the long term, pertussis vaccines and vaccination strategies should be improved to provide longer protection and prevent transmission.
authors.affiliation: Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands. sabine.de.greeff@rivm.nl
authors.forename: S C
authors.initials: SC
authors.lastname: de Greeff
authors.forename: F R
authors.initials: FR
authors.lastname: Mooi
authors.forename: A
authors.initials: A
authors.lastname: Westerhof
authors.forename: J M M
authors.initials: JM
authors.lastname: Verbakel
authors.forename: M F
authors.initials: MF
authors.lastname: Peeters
authors.forename: C J
authors.initials: CJ
authors.lastname: Heuvelman
authors.forename: D W
authors.initials: DW
authors.lastname: Notermans
authors.forename: L H
authors.initials: LH
authors.lastname: Elvers
authors.forename: J F P
authors.initials: JF
authors.lastname: Schellekens
authors.forename: H E
authors.initials: HE
authors.lastname: de Melker
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D001886:Bordetella pertussis / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D004269:DNA, Bacterial / Q000235:genetics; D005191:Family Characteristics; D005192:Family Health; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D014611:Vaccination / Q000706:statistics & numerical data; D014917:Whooping Cough / Q000453:epidemiology / Q000473:pathology / Q000517:prevention & control* / Q000635:transmission*
chemical_list: D000907:Antibodies, Bacterial; D004269:DNA, Bacterial