title: Hybrid dysfunction: population genetic and quantitative genetic perspectives.
abstract: In the wake of seminal work by Dobzhansky and Muller, hybrid dysfunction is usually attributed to incompatible mutations in different genes arising in different populations. This Dobzhansky-Muller (D-M) model is among the most important contributions of theoretical population genetics. Here I make formal connections between the D-M model and the quantitative genetic interpretation of hybrid dysfunction as a combination of additive, dominance, and epistatic effects. Concerns over conceptual differences between the two approaches are unwarranted; the D-M model can be expressed as a special case of the statistical model developed for line-cross analysis in quantitative genetics. This unified theoretical framework encourages application of quantitative genetic methods to the study of speciation.
authors.affiliation: Department of Ecology and Evolutionary Biology, University of Tennessee, Knoxville, Tennessee 37996, USA. benfitz@utk.edu
authors.forename: Benjamin M
authors.initials: BM
authors.lastname: Fitzpatrick
mesh_terms: D004843:Epistasis, Genetic; D005828:Genetics, Population; D006824:Hybridization, Genetic; D008957:Models, Genetic; D015233:Models, Statistical; D019655:Quantitative Trait, Heritable