Mango extracts and the mango component mangiferin promote endothelial cell migration.
This study tested the hypothesis that mango extracts contain bioactive molecules capable of modulating endothelial cell migration, an essential step in the formation of new blood vessels or angiogenesis. The formation of new blood vessels is an important therapeutic target for diseases such as limb ischemia, coronary infarction or stroke. We examined the effect of mango peel and flesh extracts as well as the individual polyphenolic molecules, mangiferin and quercetin, on bovine aortic cell migration using a modified Boyden chamber assay. Our results show that mangiferin, and extracts rich in mangiferin, increase endothelial cell migration. The dose-effect relationship for various extracts further suggests that this action of mangiferin is modulated by other components present in the extracts. The promigratory effect of mango extracts or mangiferin was unrelated to an effect on cell proliferation, and did not involve a change in the production of matrix metalloprotease-2 or -9 by the endothelial cells. Taken together, these results suggest that mangiferin present in mango extracts may have health promoting effects in diseases related to the impaired formation of new blood vessels.
Daud
Noor Huda
NH
School of Pharmacy, University of Queensland, Woolloongabba, Queensland, Australia.
Aung
Cho Sanda
CS
Hewavitharana
Amitha K
AK
Wilkinson
Ashley S
AS
Pierson
Jean-Thomas
JT
Roberts-Thomson
Sarah J
SJ
Shaw
P Nicholas
PN
Monteith
Gregory R
GR
Gidley
Michael J
MJ
Parat
Marie-Odile
MO
D000818:Animals; D002417:Cattle; D002465:Cell Movement / Q000187:drug effects*; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D031022:Mangifera / Q000737:chemistry*; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D053719:Tandem Mass Spectrometry; D044004:Xanthones / Q000494:pharmacology*
D010936:Plant Extracts; D044004:Xanthones; C013592:mangiferin