Uncovering residual effects of chronic sleep loss on human performance.
Sleep loss leads to profound performance decrements. Yet many individuals believe they adapt to chronic sleep loss or that recovery requires only a single extended sleep episode. To evaluate this, we designed a protocol whereby the durations of sleep and wake episodes were increased to 10 and 32.85 hours, respectively, to yield a reduced sleep-to-wake ratio of 1:3.3. These sleep and wake episodes were distributed across all circadian phases, enabling measurement of the effects of acute and chronic sleep loss at different times of the circadian day and night. Despite recurrent acute and substantial chronic sleep loss, 10-hour sleep opportunities consistently restored vigilance task performance during the first several hours of wakefulness. However, chronic sleep loss markedly increased the rate of deterioration in performance across wakefulness, particularly during the circadian "night." Thus, extended wake during the circadian night reveals the cumulative detrimental effects of chronic sleep loss on performance, with potential adverse health and safety consequences.
Cohen
Daniel A
DA
Division of Sleep Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Wang
Wei
W
Wyatt
James K
JK
Kronauer
Richard E
RE
Dijk
Derk-Jan
DJ
Czeisler
Charles A
CA
Klerman
Elizabeth B
EB
D000328:Adult; D001288:Attention; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D015233:Models, Statistical; D011597:Psychomotor Performance; D011930:Reaction Time; D012890:Sleep; D014851:Wakefulness; D014940:Work Schedule Tolerance