The apolipoprotein E gene and Taq1A polymorphisms in childhood obesity.
Obesity is a multifactorial disease that is influenced by genetic and environmental factors. The apolipoprotein E (Apo E) polymorphism has been reported to influence some lipid profile abnormalities associated with obesity in childhood. In this study, the relationship between the Apo E gene and Taq1A polymorphisms with childhood obesity has been studied. Regarding the Apo E genotypes, e3/4 was the most frequent in both the patient and control groups. Further, there was a significance between the Apo E genotypes with low density lipoprotein and total cholesterol levels. However, no relationship was found between the Taq1A polymorphism and obesity. In conclusion, polygenic inheritance should be kept in mind when dealing with childhood obesity.
Ergun
Mehmet Ali
MA
Department of Medical Genetics, Gazi University Faculty of Medicine, Ankara, Turkey. ergun@tr.net
Karaoguz
Meral Yirmibes
MY
Koc
Altug
A
Camurdan
Orhun
O
Bideci
Aysun
A
Yazici
A Canan
AC
Cinaz
Peyami
P
D001057:Apolipoproteins E / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008055:Lipids; D009765:Obesity / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D019914:Taq Polymerase / Q000235:genetics*
D001057:Apolipoproteins E; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D002784:Cholesterol; D019914:Taq Polymerase