Generation of a novel wing colour pattern by the Wingless morphogen.
The complex, geometric colour patterns of many animal bodies have important roles in behaviour and ecology. The generation of certain patterns has been the subject of considerable theoretical exploration, however, very little is known about the actual mechanisms underlying colour pattern formation or evolution. Here we have investigated the generation and evolution of the complex, spotted wing pattern of Drosophila guttifera. We show that wing spots are induced by the Wingless morphogen, which is expressed at many discrete sites that are specified by pre-existing positional information that governs the development of wing structures. Furthermore, we demonstrate that the elaborate spot pattern evolved from simpler schemes by co-option of Wingless expression at new sites. This example of a complex design developing and evolving by the layering of new patterns on pre-patterns is likely to be a general theme in other animals.
Werner
Thomas
T
Howard Hughes Medical Institute and Laboratory of Molecular Biology, University of Wisconsin, 1525 Linden Drive, Madison, Wisconsin 53706, USA.
Koshikawa
Shigeyuki
S
Williams
Thomas M
TM
Carroll
Sean B
SB
D000818:Animals; D003116:Color; D004330:Drosophila / Q000235:genetics / Q000502:physiology*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004742:Enhancer Elements, Genetic / Q000235:genetics; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D008969:Molecular Sequence Data; D009024:Morphogenesis / Q000235:genetics / Q000502:physiology; D010858:Pigmentation / Q000235:genetics / Q000502:physiology*; D014921:Wings, Animal / Q000033:anatomy & histology / Q000502:physiology*; D051155:Wnt1 Protein / Q000235:genetics / Q000378:metabolism*
D029721:Drosophila Proteins; D051155:Wnt1 Protein; C074622:wg protein, Drosophila; C050680:y protein, Drosophila