title: A polymorphism in a staphylococcal enterotoxin receptor gene (T cell receptor BV3 recombination signal sequence) is not associated with unexplained sudden unexpected death in infancy in an Australian cohort.
abstract: Polymorphisms in genes that influence the expression of toxin receptors could contribute to Sudden Infant Death Syndrome (SIDS) and unexplained Sudden Unexpected Death in Infancy (uSUDI) for which there is evidence of toxin involvement. We aimed to determine whether TCRBV3S1 allele 2 could be involved in a staphylococcal toxic shock hypothesis for uSUDI. Observed frequencies of the TCRBV3S1*2 allele and genotype in 48 Australian uSUDI cases and 96 live comparison infants did not differ. In future the role of other toxin receptor gene polymorphisms deserves investigation.
authors.affiliation: Department of Microbiology and Infectious Diseases, SA Pathology at the Women's & Children's Hospital, 72 King William Road, North Adelaide, South Australia, Australia. amanda.highet@adelaide.edu.au
authors.forename: Amanda R
authors.initials: AR
authors.lastname: Highet
authors.forename: Catherine S
authors.initials: CS
authors.lastname: Gibson
authors.forename: Paul N
authors.initials: PN
authors.lastname: Goldwater
mesh_terms: D000483:Alleles; D001315:Australia; D015331:Cohort Studies; D005260:Female; D006162:Guanylate Cyclase / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D011110:Polymorphism, Genetic; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled; D018000:Receptors, Peptide / Q000235:genetics*; D013398:Sudden Infant Death / Q000235:genetics*
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta; D018000:Receptors, Peptide; C484522:TCR Vbeta3 protein, human; D006162:Guanylate Cyclase; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled