title: Successful treatment of post-stroke apathy by the dopamine receptor agonist ropinirole.
abstract: Dopamine D2/3 receptor agonists have been widely used to treat motor symptoms in Parkinson's disease and are also reported to improve cognitive and emotional disturbances. Here we describe a patient who developed severe apathy after cerebral infarction in the prefrontal cortex. After administration of ropinirole, his verbal output and spontaneity in daily life was improved remarkably. This improvement was associated with increased blood flow in the prefrontal cortex and basal ganglia. We suggest that ropinirole may be a treatment option for deficits in motivated behavior after prefrontal damage.
authors.affiliation: Department of Neurology, Faculty of Medicine, Shimane University, 89-1 Enya-cho, Izumo 693 8501, Japan.
authors.forename: Naoto
authors.initials: N
authors.lastname: Kohno
authors.forename: Satoshi
authors.initials: S
authors.lastname: Abe
authors.forename: Genya
authors.initials: G
authors.lastname: Toyoda
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Oguro
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Bokura
authors.forename: Shuhei
authors.initials: S
authors.lastname: Yamaguchi
mesh_terms: D019797:3-Iodobenzylguanidine; D000369:Aged, 80 and over; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D018491:Dopamine Agonists / Q000627:therapeutic use*; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D019964:Mood Disorders / Q000188:drug therapy* / Q000209:etiology*; D011877:Radionuclide Imaging; D020521:Stroke / Q000150:complications*
chemical_list: D018491:Dopamine Agonists; D007211:Indoles; C046649:ropinirole; D019797:3-Iodobenzylguanidine