[Experimental study of the wound-healing effect of new drug compositions intended for the therapy of esophageal burns].
The anti-inflammatory and wound-healing effects of new formulations for the treatment of esophageal burns have been studied in Chinchilla rabbits with model chemical burns of skin. The healing process was evaluated according to the clinical and morphological criteria on the 3rd, 7th, 10th, 14th, and 21st day. It is established that the new drugs accelerate the regeneration of skin tissue in comparison to that in the control and reference groups of animals. At the late stage of skin regeneration, this is manifested by reliable differences in the degrees of cicatrization and tissue collagenization. Two hydrophilic polymer-based drug compositions, which are successively applied in accordance with the burn process development, exhibit pronounced anti-inflammatory and skin-regenerative effects. These formulations can be recommended for the therapy of esophageal burns.
Vorob'eva
V M
VM
Polukhin
D G
DG
Lepilov
A V
AV
Smirnov
A K
AK
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002057:Burns, Chemical / Q000188:drug therapy* / Q000473:pathology; D002482:Cellulose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004338:Drug Combinations; D004935:Esophageal Diseases / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D008297:Male; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; C070907:Regenkur; D002482:Cellulose