Abscission accomplished by PtdIns(3)P.
Cytokinesis - the final step of mitosis in which the two daughter cells separate - requires accumulation of specific proteins and lipids at the connecting bridge to ensure cleavage by abscission. Phosphatidylinositol-3-phosphate (PtdIns(3)P), an endosomal phosphoinositide, and FYVE-CENT, a PtdIns3P-binding protein, are found in the bridge, where they contribute to the mechanism of abscission.
Montagnac
Guillaume
G
Institut Curie, Centre de Recherche, 26 rue d'Ulm, 75248 Paris Cedex 05, France. guillaume.montagnac@curie.fr
Chavrier
Philippe
P
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D002453:Cell Cycle; D018385:Centrosome / Q000201:enzymology; D048749:Cytokinesis; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism; D006801:Humans; D016547:Kinesins / Q000378:metabolism; D008938:Mitosis; D009154:Mutation; D019869:Phosphatidylinositol 3-Kinases / Q000235:genetics / Q000378:metabolism*; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D011485:Protein Binding; D021381:Protein Transport; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000201:enzymology
D002352:Carrier Proteins; D056827:Endosomal Sorting Complexes Required for Transport; D016547:Kinesins; D019869:Phosphatidylinositol 3-Kinases; D018129:Phosphatidylinositol Phosphates; D011993:Recombinant Fusion Proteins; C417670:KIF13A protein, human; C528699:ZFYVE26 protein, human; C055525:phosphatidylinositol 3-phosphate