Klinefelter's syndrome and rheumatoid arthritis: report of a case and review of the literature.
Kilnefelter's syndrome (KFS) tends to be associated with autoimmune diseases. Although several reports describe association of KFS with different autoimmune diseases, association with rheumatoid arthritis is very rare. We report a case of (KFS) who had seropositive erosive rheumatoid arthritis, and discuss the role of sex hormones/X chromosome in the pathogenesis of disease.
Al-Arfaj
Hussein F
HF
Department of Medicine, Rheumatology Division, College of Medicine, King Saud University, Riyadh, Saudi Arabia. hfarfaj@gmail.com
D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D041321:Chromosomes, Human, X; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000378:metabolism; D008297:Male; D016896:Treatment Outcome
D018501:Antirheumatic Agents; D012739:Gonadal Steroid Hormones