title: Natural products: potential for developing Phellodendron amurense bark extract for prostate cancer management.
abstract: Our ability to detect and treat most primary cancers has improved dramatically given the advances in our understanding of cancer biology. However, with increased life expectancy and our inability to treat or cure advanced stages of cancers, the number of cancer-related deaths is expected to double in the next decade. Epidemiological studies suggest that dietary factors are an important aspect that influences cancer risk. Despite a lack of scientific evidence in most cases, cancer patients have whole-heartedly accepted the concept of "alternative medicine" using natural compounds and spent more than $1B a year on herbal supplements. Given the significant toxicity-associated problems with current long-term standard of care, scientifically validated natural supplements can serve as novel and effective alternative strategies for effective cancer management. We will discuss the utility of natural products in modulating critical signaling pathways for effective cancer prevention with special emphasis on prostate cancer and their potential translational benefit.
authors.affiliation: Department of Urology, School of Medicine, 7703 Floyd Curl Drive, The University of Texas Health Science Center, San Antonio, TX 78229, USA. kumara3@uthscsa.edu
authors.forename: Addanki P
authors.initials: AP
authors.lastname: Kumar
authors.forename: Heather
authors.initials: H
authors.lastname: Graham
authors.forename: Craig
authors.initials: C
authors.lastname: Robson
authors.forename: Ian M
authors.initials: IM
authors.lastname: Thompson
authors.forename: Rita
authors.initials: R
authors.lastname: Ghosh
mesh_terms: D016588:Anticarcinogenic Agents / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D001688:Biological Products / Q000302:isolation & purification / Q000627:therapeutic use* / Q000633:toxicity; D006801:Humans; D008297:Male; D032102:Phellodendron / Q000737:chemistry*; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use / Q000633:toxicity; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D016588:Anticarcinogenic Agents; D001688:Biological Products; C512605:Nexrutine; D010936:Plant Extracts