Synthesis and structural analysis of a new class of azaspiro[3.3]heptanes as building blocks for medicinal chemistry.
Straightforward access toward previously unreported substituted, heterocyclic spiro[3.3]heptanes is disclosed. These spirocyclic systems may be considered as alternatives to 1,3-heteroatom-substituted cyclohexanes, which are otherwise insufficiently stable to allow their use in drug discovery. Conformational details are discussed on the basis of X-ray crystallographic structures.
Burkhard
Johannes A
JA
Laboratorium für Organische Chemie, ETH Zürich, CH-8093 Zürich, Switzerland.
Guérot
Carine
C
Knust
Henner
H
Rogers-Evans
Mark
M
Carreira
Erick M
EM
D018360:Crystallography, X-Ray; D006536:Heptanes / Q000138:chemical synthesis* / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure
D006536:Heptanes