[Preparation of submicron emulsion of fresh Zhongjiefeng volatile oil].
OBJECTIVE
To prepare the submicron emulsion of fresh Zhongjiefeng volatile oil.


METHODS
The Zhongjiefeng volatile oil submicron emulsion was obtained after passing the elementary emulsion through a high pressure homogenizer. The physical and chemical stability of the emulsion was evaluated with the stability parameter of centrifugation, appearance of emulsion and the pH. The formulation and processing factors were optimized by single factor reviewing and orthogonal experimental design.


RESULTS
By controlling various processing factors and optimizing formulation, the stable submicron emulsion of Zhongjiefeng volatile oil was prepared. Its mean particle diameter was 164-169 nm with PDI 0.084-0.107 and Zeta electric potential was -40 mV.


CONCLUSIONS
The formulation and preparation technique of the emulsion is reasonable.
Wu
Suxiang
S
Zhejiang Chinese Medical University, Hangzhou 310053, China.
Lv
Guiyuan
G
Chen
Suhong
S
Zhang
Shengna
S
Zhao
Lishan
L
Zhou
Rihe
R
Zhou
Huakang
H
D004355:Drug Stability; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry*; D009822:Oils, Volatile / Q000737:chemistry*
D004365:Drugs, Chinese Herbal; D004655:Emulsions; D009822:Oils, Volatile