title: A FTO variant and risk of acute coronary syndrome.
abstract: BACKGROUND
  The FTO gene plays an important role in the determination of body weight and BMI and it has been suspected of being associated with all-case mortality.
  
  
  METHODS
  We have analyzed the FTO rs17817449 variant in consecutive 1092 male patients with acute coronary syndrome (ACS) and in 1191 randomly selected Caucasian individuals (population controls).
  
  
  RESULTS
  The FTO variant was significantly associated with BMI both in controls (P<0.02) and ACS patients (P<0.01). In both groups, BMI was highest in GG homozygotes and lowest in TT homozygotes. There was a significant difference between the ACS patients and controls in the frequency of the FTO genotype GG (21.4% vs. 15.9%, P<0.005). FTO GG homozygotes had a significantly increased risk of ACS, compared with TT homozygotes which was independent of age and BMI (odds ratio 1.49, 95% confidence interval 1.16-1.93). The odds ratio of ACS patients for the GG genotype remained significant even after the exclusion of diabetics (100 controls and 339 ACS patients), with OR 1.32 (95% CI 1.01-1.72).
  
  
  CONCLUSIONS
  This study provides an evidence of an association between the FTO variant and risk of ACS in Caucasian males.
authors.affiliation: Institute for Clinical and Experimental Medicine, Prague, Czech Republic. jahb@ikem.cz
authors.forename: Jaroslav A
authors.initials: JA
authors.lastname: Hubacek
authors.forename: Vladimír
authors.initials: V
authors.lastname: Stanek
authors.forename: Marie
authors.initials: M
authors.lastname: Gebauerová
authors.forename: Alexandra
authors.initials: A
authors.lastname: Pilipcincová
authors.forename: Dana
authors.initials: D
authors.lastname: Dlouhá
authors.forename: Rudolf
authors.initials: R
authors.lastname: Poledne
authors.forename: Michal
authors.initials: M
authors.lastname: Aschermann
authors.forename: Hana
authors.initials: H
authors.lastname: Skalická
authors.forename: Jana
authors.initials: J
authors.lastname: Matousková
authors.forename: Andreas
authors.initials: A
authors.lastname: Kruger
authors.forename: Martin
authors.initials: M
authors.lastname: Penicka
authors.forename: Hana
authors.initials: H
authors.lastname: Hrabáková
authors.forename: Josef
authors.initials: J
authors.lastname: Veselka
authors.forename: Petr
authors.initials: P
authors.lastname: Hájek
authors.forename: Vera
authors.initials: V
authors.lastname: Lánská
authors.forename: Vera
authors.initials: V
authors.lastname: Adámková
authors.forename: Jan
authors.initials: J
authors.lastname: Pitha
mesh_terms: D054058:Acute Coronary Syndrome / Q000235:genetics*; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000235:genetics*; D012307:Risk Factors
chemical_list: D011506:Proteins; D000071516:Alpha-Ketoglutarate-Dependent Dioxygenase FTO; C526492:FTO protein, human