Cycling toward elimination of leukemic stem cells.
In two recent articles in Science Translational Medicine and Nature Biotechnology, Saito et al. (2010) identify a molecular signature of acute myeloid leukemia (AML) stem cells and demonstrate that quiescent AML stem cells become sensitized to chemotherapy after G-CSF stimulation.
Goff
Daniel
D
Department of Medicine and Moores Cancer Center, University of California at San Diego, San Diego, CA 92093, USA.
Jamieson
Catriona
C
Department of Medicine and Moores Cancer Center, University of California at San Diego, San Diego, CA 92093, USA. Electronic address: cjamieson@ucsd.edu.