title: Regulating redox balance gene expression in healthy individuals by nutraceuticals: a pilot study.
abstract: We tested the effect of a fermented papaya preparation (FPP; ORI, Gifu, Japan) on redox balance gene expression in 11 healthy nonsmoker, teetotaller individuals subjected to a detailed dietary and lifestyle questionnaire who refrained from any multivitamin supplement or fortified food. Redox status was assessed by erythrocyte and plasma parameters together with related leukocyte mRNA (glutathione peroxidase [GPx], superoxide dismutase [SOD], catalase, 8-oxoguanine glycosylase [hOGG1]) before/after 6 grams of FPP supplementation. At 2 and 4 weeks after FPP administration, plasma parameters remained unchanged, whereas FPP significantly upregulated all tested gene expression (p < 0.05). Although posttranscriptional/translation protein modifications do occur and larger and longer studies are awaited, these preliminary data suggest that a transcriptomic modification of key redox and DNA repair genes may offer further insights when attempting to interrelate "nutragenomics" to clinical phenomena.
authors.affiliation: ReGenera Research Group, Milano, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Marotta
authors.forename: Keiko
authors.initials: K
authors.lastname: Koike
authors.forename: Aldo
authors.initials: A
authors.lastname: Lorenzetti
authors.forename: Shalini
authors.initials: S
authors.lastname: Jain
authors.forename: Paola
authors.initials: P
authors.lastname: Signorelli
authors.forename: Yussef
authors.initials: Y
authors.lastname: Metugriachuk
authors.forename: Pierre
authors.initials: P
authors.lastname: Mantello
authors.forename: Nicola
authors.initials: N
authors.lastname: Locorotondo
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D029441:Carica / Q000737:chemistry; D002374:Catalase / Q000097:blood / Q000235:genetics / Q000378:metabolism; D045647:DNA Glycosylases / Q000097:blood / Q000235:genetics / Q000378:metabolism; D019587:Dietary Supplements; D005260:Female; D005285:Fermentation; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects*; D005979:Glutathione Peroxidase / Q000097:blood / Q000235:genetics / Q000378:metabolism; D006262:Health; D006801:Humans; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D010865:Pilot Projects; D010936:Plant Extracts / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000097:blood / Q000235:genetics / Q000378:metabolism; D055815:Young Adult
chemical_list: D000975:Antioxidants; D016877:Oxidants; D010936:Plant Extracts; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human