title: Single-molecule rupture dynamics on multidimensional landscapes.
abstract: We explore emergent effects of multidimensionality of the free energy landscape on single-molecule kinetics under constant force. The proposed minimal model reveals the existence of a spectrum of unusual scenarios for the force-dependent lifetime, all of which are shown to occur on a free energy landscape with a single transition state. We present an analytical solution that governs single-molecule responses to a constant force and relates them to microscopic parameters of the system.
authors.affiliation: Department of Physics and Center for Theoretical Biological Physics, University of California at San Diego, La Jolla, California 92093, USA.
authors.forename: Yohichi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Olga K
authors.initials: OK
authors.lastname: Dudko
mesh_terms: D003198:Computer Simulation; D008956:Models, Chemical; D013816:Thermodynamics; D013997:Time Factors