title: [Semen cryopreservation applied to intrauterine insemination cycles for oligospermia and asthenospermia in infertile men].
abstract: OBJECTIVE
  To explore the application value of semen cryopreservation in intrauterine insemination cycles for the treatment of oligospermia and asthenospermia in infertile males.
  
  
  METHODS
  A total of 152 cycles of intrauterine insemination were performed for 103 couples with constitutional infertility, which were divided into Groups 1 (normal semen, n=53), 2 (oligospermia and asthenospermia, n=52) and 3 (fresh combined with cryopreserved semen, n=47). Semen parameters and forward motile sperm count after processing were recorded by Makler chamber, and all were followed up for the outcome of clinical pregnancy.
  
  
  RESULTS
  Compared with Group 2, Group 3 showed obviously lower semen volume, sperm motility and grade a sperm count before semen processing, with extremely significant differences (P < 0.01), but a higher rate of grade a sperm after semen processing, though with no significant differences (P > 0.05). There were no statistically significant differences in the pregnancy rate between Groups 2 and 3 (9.6% versus 14.9%, P > 0.05).
  
  
  CONCLUSIONS
  Semen cryopreservation can improve the forward motile sperm count and pregnancy rate in oligospermia and asthenospermia patients after intrauterine insemination. Semen cryopreservation combined with intrauterine insemination seems an ideal treatment for oligospermia and asthenospermia in infertile men.
authors.affiliation: Department of Reproductive Medicine, The First Affiliated Hospital of Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu 210029, China.
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Nie
authors.forename: Yun
authors.initials: Y
authors.lastname: Qian
authors.forename: Cheng-yong
authors.initials: CY
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Tan
mesh_terms: D053627:Asthenozoospermia / Q000628:therapy*; D015925:Cryopreservation; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000628:therapy*; D007317:Insemination, Artificial, Homologous / Q000379:methods*; D008297:Male; D009845:Oligospermia / Q000628:therapy*; D011247:Pregnancy; D018873:Pregnancy Rate