title: Reduced systemic bone mineral density associated with a rare case of tooth and nail syndrome.
abstract: This is the first report of a rare genetic tooth and nail syndrome (TNS) diagnosed in a 14-year-old Caucasian girl with a complete absence of the permanent dentition and, additionally, reduced total and lumbar spine bone mineral density (BMD). This coincidence suggests a new clinical manifestation of the disorder in which genetic factors and/or shared mechanisms may be responsible for the deterioration of the stomatognathic system, anodontia, nail phenotype and osteopenia. Low bone mass appears to be a new component of the syndrome. There is a rationale for bone densitometry scans assuming that patients with TNS may have an increased risk of osteopenia. Reduced BMD and, possibly, impaired bone quality and strength may produce difficulties or even exclude such patients from future treatment with dental implants.
authors.affiliation: Department of Prosthetic Dentistry, Medical University of Bialystok, Bialystok, Poland. teresasierpinska@net.bialystok.pl
authors.forename: T
authors.initials: T
authors.lastname: Sierpinska
authors.forename: I
authors.initials: I
authors.lastname: Szarmach
authors.forename: J
authors.initials: J
authors.lastname: Konstantynowicz
authors.forename: J
authors.initials: J
authors.lastname: Szarmach
authors.forename: M
authors.initials: M
authors.lastname: Golebiewska
mesh_terms: D000293:Adolescent; D000848:Anodontia / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D009264:Nails, Malformed / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology; D014071:Tooth Abnormalities / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology