Dodecaborate lipid liposomes as new vehicles for boron delivery system of neutron capture therapy.
Closo-dodecaborate lipid liposomes were developed as new vehicles for boron delivery system (BDS) of neutron capture therapy. The current approach is unique because the liposome shell itself possesses cytocidal potential in combination with neutron irradiation. The liposomes composed of closo-dodecaborate lipids DSBL and DPBL displayed high cytotoxicity with thermal neutron irradiation. The closo-dodecaborate lipid liposomes were taken up into the cytoplasm by endocytosis without degradation of the liposomes. Boron concentration of 22.7 ppm in tumor was achieved by injection with DSBL-25% PEG liposomes at 20mg B/kg. Promising BNCT effects were observed in the mice injected with DSBL-25% PEG liposomes: the tumor growth was significantly suppressed after thermal neutron irradiation (1.8 x 10(12)neutrons/cm(2)).
Ueno
Manabu
M
Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima-ku, Tokyo 171-8588, Japan.
Ban
Hyun Seung
HS
Nakai
Kei
K
Inomata
Ryu
R
Kaneda
Yasufumi
Y
Matsumura
Akira
A
Nakamura
Hiroyuki
H
D000818:Animals; D001895:Boron / Q000008:administration & dosage*; D001896:Boron Compounds / Q000737:chemistry*; D016754:Boron Neutron Capture Therapy; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D005260:Female; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D046529:Microscopy, Electron, Transmission; D009369:Neoplasms / Q000532:radiotherapy*; D019275:Radiopharmaceuticals; D014018:Tissue Distribution; D047368:Tumor Burden
D001896:Boron Compounds; D008055:Lipids; D008081:Liposomes; D019275:Radiopharmaceuticals; C119788:dodecaborate; D001895:Boron