title: Trajectory control of PbSe-gamma-Fe2O3 nanoplatforms under viscous flow and an external magnetic field.
abstract: The flow behavior of nanostructure clusters, consisting of chemically bonded PbSe quantum dots and magnetic gamma-Fe(2)O(3) nanoparticles, has been investigated. The clusters are regarded as model nanoplatforms with multiple functionalities, where the gamma-Fe(2)O(3) magnets serve as transport vehicles, manipulated by an external magnetic field gradient, and the quantum dots act as fluorescence tags within an optical window in the near-infrared regime. The clusters' flow was characterized by visualizing their trajectories within a viscous fluid (mimicking a blood stream), using an optical imaging method, while the trajectory pictures were analyzed by a specially developed processing package. The trajectories were examined under various flow rates, viscosities and applied magnetic field strengths. The results revealed a control of the trajectories even at low magnetic fields (<1 T), validating the use of similar nanoplatforms as active targeting constituents in personalized medicine.
authors.affiliation: Russell Berrie Nanotechnology Institute (RBNI), Technion-Israel Institute of Technology, Haifa, Israel.
authors.forename: Lioz
authors.initials: L
authors.lastname: Etgar
authors.forename: Arie
authors.initials: A
authors.lastname: Nakhmani
authors.forename: Allen
authors.initials: A
authors.lastname: Tannenbaum
authors.forename: Efrat
authors.initials: E
authors.lastname: Lifshitz
authors.forename: Rina
authors.initials: R
authors.lastname: Tannenbaum
mesh_terms: D000465:Algorithms; D016503:Drug Delivery Systems; D004574:Electromagnetic Fields; D005290:Ferric Compounds / Q000737:chemistry*; D007854:Lead / Q000737:chemistry*; D044085:Microfluidics / Q000379:methods; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D045663:Quantum Dots; D018036:Selenium Compounds / Q000737:chemistry*; D014584:User-Computer Interface; D014783:Viscosity
chemical_list: D005290:Ferric Compounds; D018036:Selenium Compounds; C088065:lead selenide; C000499:ferric oxide; D007854:Lead