Comparison of Langevin and Markov channel noise models for neuronal signal generation.
The stochastic opening and closing of voltage-gated ion channels produce noise in neurons. The effect of this noise on the neuronal performance has been modeled using either an approximate or Langevin model based on stochastic differential equations or an exact model based on a Markov process model of channel gating. Yet whether the Langevin model accurately reproduces the channel noise produced by the Markov model remains unclear. Here we present a comparison between Langevin and Markov models of channel noise in neurons using single compartment Hodgkin-Huxley models containing either Na+ and K+, or only K+ voltage-gated ion channels. The performance of the Langevin and Markov models was quantified over a range of stimulus statistics, membrane areas, and channel numbers. We find that in comparison to the Markov model, the Langevin model underestimates the noise contributed by voltage-gated ion channels, overestimating information rates for both spiking and nonspiking membranes. Even with increasing numbers of channels, the difference between the two models persists. This suggests that the Langevin model may not be suitable for accurately simulating channel noise in neurons, even in simulations with large numbers of ion channels.
Sengupta
B
B
Neural Circuit Design Group, Department of Zoology, University of Cambridge, Cambridge CB2 3EJ, UK. bs393@cam.ac.uk
Laughlin
S B
SB
Niven
J E
JE
D000200:Action Potentials; D000465:Algorithms; D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D003198:Computer Simulation; D007257:Information Theory; D008390:Markov Chains; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D016011:Normal Distribution; D024642:Potassium Channels, Voltage-Gated / Q000378:metabolism*; D011336:Probability; D015222:Sodium Channels / Q000378:metabolism*; D013269:Stochastic Processes
D024642:Potassium Channels, Voltage-Gated; D015222:Sodium Channels