title: Profile of hepatitis A infection with atypical manifestations in children.
abstract: We assessed the clinical course and biochemical profile of symptomatic children with viral hepatitis A who had atypical manifestations. Of 229 children with hepatitis A, atypical manifestations were found in 32 (14%) subjects. Prolonged cholestasis (n = 14), acute liver failure (9), relapse (9), ascites (8), and hematological problems (8) were the common presentations. Liver histology was suggestive of chronic liver disease in six children with protracted jaundice. Patients with atypical presentations were older (7.7 [1.6] years vs. 6.5 [2.6] years; p=0.012) and had higher total serum bilirubin (13.7 [8.1] mg/dL vs. 7.2 [4.0] mg/dL; p=<0.001) than those with typical presentation. Approximately 15% of children with acute hepatitis A infection have atypical presentation which is associated with increase in morbidity.
authors.affiliation: Department of Pediatrics, Nilratan Sircar Medical College and Hospital, Kolkata, 700 014, India. ts_ped@rediffmail.com
authors.forename: Tryambak
authors.initials: T
authors.lastname: Samanta
authors.forename: Anjan Kumar
authors.initials: AK
authors.lastname: Das
authors.forename: Sutapa
authors.initials: S
authors.lastname: Ganguly
mesh_terms: D000367:Age Factors; D001201:Ascites / Q000209:etiology; D001663:Bilirubin / Q000097:blood; D002648:Child; D002779:Cholestasis / Q000209:etiology; D016001:Confidence Intervals; D005260:Female; D006506:Hepatitis A / Q000150:complications* / Q000453:epidemiology*; D006801:Humans; D007194:India / Q000453:epidemiology; D007565:Jaundice / Q000209:etiology; D017114:Liver Failure, Acute / Q000209:etiology; D008297:Male; D012307:Risk Factors
chemical_list: D001663:Bilirubin