title: An efficient entry to 1,2-benzisoxazoles via 1,3-dipolar cycloaddition of in situ generated nitrile oxides and benzyne.
abstract: An efficient protocol for the synthesis of a range of 1,2-benzisoxazoles using an improved 1,3-dipolar cycloaddition of nitrile oxides and benzyne is described. Key to the procedure is the in situ generation of the reactive nitrile oxide and benzyne reactants simultaneously.
authors.affiliation: School of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
authors.forename: Christian
authors.initials: C
authors.lastname: Spiteri
authors.forename: Christopher
authors.initials: C
authors.lastname: Mason
authors.forename: Fengzhi
authors.initials: F
authors.lastname: Zhang
authors.forename: Dougal J
authors.initials: DJ
authors.lastname: Ritson
authors.forename: Pallavi
authors.initials: P
authors.lastname: Sharma
authors.forename: Steve
authors.initials: S
authors.lastname: Keeling
authors.forename: John E
authors.initials: JE
authors.lastname: Moses
mesh_terms: D001555:Benzene Derivatives / Q000737:chemistry*; D003500:Cyclization; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D062367:ortho-Aminobenzoates / Q000737:chemistry
chemical_list: C441200:1,2-benzisoxazole; D001555:Benzene Derivatives; D007555:Isoxazoles; D009570:Nitriles; D010087:Oxides; C524146:benzyne; D062367:ortho-Aminobenzoates; C031385:anthranilic acid