title: Serum uric acid, plasma glucose and diabetes.
abstract: The objective of this study was to investigate the association of serum UA with either FPG or 2hPG levels among Chinese adults in Qingdao, China. A population-based survey for diabetes was performed in 2006 in Qingdao. The survey included 1,490 men and 2,325 women aged 35-74 years who had data stored as required for the current data analysis. The association of mean UA with plasma glucose was tested using a linear regression model. Serum UA concentration raised with increasing FPG levels up to FPG of 7.0 mmol/l, but significantly decreased thereafter with further increase in FPG levels. The multivariate adjusted beta coefficient between FPG and UA in individuals with newly diagnosed diabetes was -0.20 for men and -0.27 for women (p<0.01 for both). A declining trend for the UA concentration was also observed at 2hPG of 10 mmol/l or higher in both genders. Fasting serum UA levels was higher in the pre-diabetic population but lower in people with diabetes than in normoglycaemic people. UA may serve as a potential biomarker of deterioration in glucose metabolism, but its clinical implication need to be further studied.
authors.affiliation: Department of Public Health, University of Helsinki, Helsinki, Finland. hairong.nan@helsinki.fi
authors.lastname: Hairong Nan
authors.lastname: Zengchang Pang
authors.lastname: Shaojie Wang
authors.lastname: Weiguo Gao
authors.lastname: Lei Zhang
authors.lastname: Jie Ren
authors.lastname: Feng Ning
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
authors.lastname: Qing Qiao
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis* / Q000208:ethnology; D005260:Female; D006306:Health Surveys; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011236:Prediabetic State / Q000097:blood* / Q000175:diagnosis* / Q000208:ethnology; D012424:Rural Population / Q000706:statistics & numerical data; D014505:Urban Population / Q000706:statistics & numerical data; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D014527:Uric Acid