A target-specific electrode and lead design for internal globus pallidus deep brain stimulation.
In nearly all deep brain stimulation (DBS) applications, the same quadripolar electrode design is used for different anatomical targets even if shape and volume differences exist between nuclei. Taking into account the electrode location within the internal globus pallidus (GPi) and the size of the GPi, 2 electrodes were designed in order to improve the therapeutic benefit, to minimize side effects from DBS and to obtain a more homogeneous electric field distribution. The electrodes were evaluated numerically by using a stereotactic model measuring the correlation between the electric field and the GPi. The model was applied to 26 dystonodyskinetic patients who underwent surgery for a bilateral lead implantation into the posteroventral part of the GPi. The designed electrodes produced a more homogeneous distribution of the electric field than the quadripolar electrode.
Vasques
Xavier
X
Service de Neurochirurgie, CHRU Montpellier, Montpellier, France.
Cif
Laura
L
Mennessier
Gérard
G
Coubes
Philippe
P
D000293:Adolescent; D000328:Adult; D046690:Deep Brain Stimulation / Q000295:instrumentation*; D020821:Dystonic Disorders / Q000628:therapy*; D004567:Electrodes, Implanted; D005260:Female; D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008959:Models, Neurological; D016896:Treatment Outcome