Role of GW182 proteins and PABPC1 in the miRNA pathway: a sense of déjà vu.
GW182 proteins have emerged as key components of microRNA (miRNA) silencing complexes in animals. Although the precise molecular function of GW182 proteins is not fully understood, new findings indicate that they act as poly(A)-binding protein (PABP)-interacting proteins (PAIPs) that promote gene silencing, at least in part, by interfering with cytoplasmic PABP1 (PABPC1) function during translation and mRNA stabilization. This recent discovery paves the way for future studies of miRNA silencing mechanisms.
Tritschler
Felix
F
Department of Biochemistry, Max Planck Institute for Developmental Biology, Spemannstrasse 35, Tübingen, Germany.
Huntzinger
Eric
E
Izaurralde
Elisa
E
D000595:Amino Acid Sequence; D000818:Animals; D001324:Autoantigens / Q000737:chemistry / Q000378:metabolism*; D001665:Binding Sites; D020868:Gene Silencing; D035683:MicroRNAs / Q000378:metabolism*; D008969:Molecular Sequence Data; D039122:Poly(A)-Binding Protein I / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011485:Protein Binding; D017434:Protein Structure, Tertiary
D001324:Autoantigens; D035683:MicroRNAs; D039122:Poly(A)-Binding Protein I