title: [New ophthalmic insert].
abstract: Controlled release of drugs on ocular level is an important care for modern pharmacology. New studies targets are medical ophthalmic products with prolonged action (controlled release, target release). The hydrogel is an important segment in these studies. The purpose of this study is to assess a monolithic thermosensible hydrogel for releasing a certain medical product.
  
  
  METHODS
  We used several materials for making thermosensible ophthalmic inserts that were processed (hydrogel synthesis, establish the inflation degree, hydrogel drug inclusion, establish the kinetics of in vitro drug releasing, in vivo studies).
  
  
  RESULTS
  The study show that MA-G and PNIPAm basis hydrogel is a smart one that have the ability to collapse on a temperature closed to the physiological one, the result is the drug release in a desired doses. The hydrogel is perfectly tolerated, an experimental study prove that.
  
  
  CONCLUSIONS
  Controlled release of active drug that are highly adequate to have a clinical response is based on small doses, without adverse effects. Is a target release.
authors.affiliation: "Gh. Asachi" Technical University, Faculty of Chemical Engineering, Department of Natural and Synthetic Polymers, Bd. D. Mangeron, nr. 71 A, 700050 Iasi, Romania.
authors.forename: Mihaela
authors.initials: M
authors.lastname: Hamcerencu
authors.forename: Marcel
authors.initials: M
authors.lastname: Popa
authors.forename: Danut
authors.initials: D
authors.lastname: Costin
authors.forename: Paul
authors.initials: P
authors.lastname: Bucatariu
authors.forename: Jacques
authors.initials: J
authors.lastname: Desebrieres
authors.forename: Gerard
authors.initials: G
authors.lastname: Riess
mesh_terms: D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry*; D004343:Drug Implants; D005128:Eye Diseases / Q000188:drug therapy*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000138:chemical synthesis* / Q000737:chemistry*; D016896:Treatment Outcome
chemical_list: D004337:Drug Carriers; D004343:Drug Implants; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate