Copper-promoted N-cyclopropylation of anilines and amines by cyclopropylboronic acid.
Reaction of anilines, primary and secondary aliphatic amines with cyclopropylboronic acid in dichloroethane in the presence of Cu(OAc)(2) (1 equiv.), 2,2'-bipyridine (1 equiv.) and sodium carbonate or sodium bicarbonate (2 equiv.) under air atmosphere afforded the corresponding N-cyclopropyl derivatives in good to excellent yields.
Bénard
Sébastien
S
Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette, France.
Neuville
Luc
L
Zhu
Jieping
J
D000588:Amines / Q000737:chemistry*; D000814:Aniline Compounds / Q000737:chemistry*; D001897:Boronic Acids / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D003521:Cyclopropanes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism
D000588:Amines; D000814:Aniline Compounds; D001897:Boronic Acids; D003521:Cyclopropanes; D009942:Organometallic Compounds; D003300:Copper; C023650:aniline