title: Comparative study of the immunobiological properties of live brucellosis vaccines.
abstract: Findings from the comparative study of the immunobiological properties of live brucellosis vaccines in guinea pigs are presented in the article. Vaccines from strains Brucella abortus 19 (U.S.) and 82 (Russia), in the S and SR forms, respectively, exhibited the highest and most pronounced immunological efficacy, while vaccines from strains B. abortus 82-PS (in the RS form) and B. abortus RB-51 and 75/79-AB (in the R forms) exhibited the lowest. The live vaccine from strain B. abortus 82, together with a high immunological activity, possesses inagglutinogenic properties. The great advantage of this vaccine over the vaccine from strain B. abortus 19 is that after its use in animals the problem of the differential diagnosis of brucellosis becomes much simpler. The live vaccine from strain B. abortus 82 was adopted in veterinary practice in the Russian Federation; it is widely used for the targeted prevention of bovine brucellosis, but can also be used successfully for wild animals such as bison, deer, elk, and others.
authors.affiliation: Federal Center for Toxicological and Radiation Animal Safety, A Federal State Institute FCTRAS-VNIVI [All-Russian Research Veterinary Institute], 2 Nauchnyi proezd, Kazan, Tatarstan, Russia. vnivi@mail.ru
authors.forename: K M
authors.initials: KM
authors.lastname: Salmakov
authors.forename: A M
authors.initials: AM
authors.lastname: Fomin
authors.forename: E M
authors.initials: EM
authors.lastname: Plotnikova
authors.forename: G M
authors.initials: GM
authors.lastname: Safina
authors.forename: G M
authors.initials: GM
authors.lastname: Galimova
authors.forename: A V
authors.initials: AV
authors.lastname: Salmakova
authors.forename: A V
authors.initials: AV
authors.lastname: Ivanov
authors.forename: A N
authors.initials: AN
authors.lastname: Panin
authors.forename: O D
authors.initials: OD
authors.lastname: Sklyarov
authors.forename: K V
authors.initials: KV
authors.lastname: Shumilov
authors.forename: A I
authors.initials: AI
authors.lastname: Klimanov
mesh_terms: D000034:Abortion, Veterinary / Q000382:microbiology / Q000517:prevention & control; D000818:Animals; D002004:Brucella Vaccine / Q000008:administration & dosage / Q000276:immunology*; D002003:Brucella abortus / Q000276:immunology* / Q000472:pathogenicity; D002006:Brucellosis / Q000276:immunology / Q000517:prevention & control*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D011247:Pregnancy; D014774:Virulence
chemical_list: D002004:Brucella Vaccine