title: Oxindole synthesis by palladium-catalysed aromatic C-H alkenylation.
abstract: A strategy involving palladium-catalysed aromatic C-H functionalisation/intramolecular alkenylation provides a convenient and direct synthesis of 3-alkylideneoxindoles. In the presence of 5 mol% of PdCl(2)MeCN(2) and AgOCOCF(3), a wide variety of N-cinnamoylanilines gave 3-alkylideneoxindoles in moderate to good yield.
authors.affiliation: Laboratory of Medicinal and Pharmaceutical Chemistry, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu 501-1196, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ueda
authors.forename: Takahiro
authors.initials: T
authors.lastname: Okada
authors.forename: Hideko
authors.initials: H
authors.lastname: Nagasawa
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D000078183:Oxindoles; D010165:Palladium / Q000737:chemistry*
chemical_list: D000475:Alkenes; D007211:Indoles; D000078183:Oxindoles; C022960:2-oxindole; D010165:Palladium