title: Proteomic and metabolomic strategies to investigate HIV-associated neurocognitive disorders.
abstract: Diagnosing neurodegenerative diseases, monitoring their progression and assessing responses to treatments will all be aided by the identification of molecular markers of different stages of pathology. Protein biomarkers for HIV-associated neurocognitive disorders that have been discovered using proteomics include complement C3, soluble superoxide dismutase and a prostaglandin synthase. Metabolomics has not yet been widely used for biomarker discovery, but early work shows that it has great potential.
authors.affiliation: Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, 985800 Nebraska Medical Center, Omaha, NE 68198, USA. gpendyala@unmc.edu.
authors.forename: Gurudutt
authors.initials: G
authors.lastname: Pendyala
authors.forename: Howard S
authors.initials: HS
authors.lastname: Fox