Aging is not a process of wear and tear.
The idea that bodies wear out with age is so ancient, so pervasive, and so deeply rooted that it affects our thought in unconscious ways. Undeniably, many aspects of aging, e.g., oxidative damage, somatic mutations, and protein cross-linkage are characterized by increased entropy in biomolecules. However, it has been a scientific consensus for more than a century that there is no physical necessity for such damage. Living systems are defined by their capacity to gather order from their environment, concentrate it, and shed entropy with their waste. Organisms in their growth phase become stronger and more robust; no physical law prohibits this progress from continuing indefinitely. Indeed, some animals and many plants are known to grow indefinitely larger and more fertile through their lives. The same conclusion is underscored by experimental findings that various insults and challenges that directly damage the body or increase the rate of wear and tear have the paradoxical effect of extending life span. Hyperactive mice live longer than controls, and worms with their antioxidant systems impaired live longer than wild type. A fundamental understanding of aging must proceed not from physics but from an evolutionary perspective: The body is being permitted to decay because systems of repair and regeneration that are perfectly adequate to build and rebuild a body of ever-increasing resilience are being held back. Regardless of the reason for this retreat, it should be more fruitful to focus on signaling to effect the ongoing activity of systems of repair and regeneration than to attempt repair of the manifold damage left in the wake of their failure.
Mitteldorf
Josh
J
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, USA. josh@mathforum.org
D000375:Aging / Q000502:physiology*; D000818:Animals; D005075:Biological Evolution; D016922:Cellular Senescence / Q000502:physiology; D004194:Disease / Q000209:etiology; D006801:Humans; D051379:Mice; D018384:Oxidative Stress / Q000502:physiology; D014947:Wounds and Injuries / Q000150:complications* / Q000209:etiology