title: [Laparoscopic total mesorectal excision for extraperitoneal rectal cancer. Oncological outcome at 5 years].
abstract: Total mesorectal excision (TME) is the cornerstone of surgical treatment for extraperitoneal rectal cancer. The aim of the present study was to analyse our five-year experience with laparoscopic TME, evaluating the overall five-year and disease-free survival rates. Twenty-five patients with low-middle rectal cancer were treated with laparoscopic TME. Patients with advanced rectal cancer were treated preoperatively with neoadjuvant radiochemotherapy. Five-year overall survival and disease-free survival were calculated according to the Kaplan-Meier method. Twenty-three ultralow anterior resections with Knight-Griffen anastomosis and 3 abdominoperineal resections were performed. At 30 days mortality was zero, while morbidity was 20% (all minor complications). The mean follow-up period was 30.5 months. Five-year overall survival was 80.2%, and five-year disease-free survival 80.9%. Our experience shows that laparoscopic TME is a safe and oncologically correct procedure. Oncologic outcomes were comparable to those reported in all major international experiences, and the results were very similar to those obtained with the laparotomic approach. However, it remains a complex technique, requiring an adequate learning curve. More prospective, randomised trials are needed in order to define laparoscopic TME as the new gold standard for the treatment of extraperitoneal rectal cancer.
authors.affiliation: U.O.C. Chirurgia Generale e Mininvasiva, Ospedale "San Paolo", ASL-RM/F, Civitavecchia, Roma.
authors.forename: Luca Maria
authors.initials: LM
authors.lastname: Siani
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Ferranti
authors.forename: Antonio
authors.initials: A
authors.lastname: De Carlo
authors.forename: Marco
authors.initials: M
authors.lastname: Marzano
authors.forename: Alberto
authors.initials: A
authors.lastname: Quintiliani
mesh_terms: D000328:Adult; D000368:Aged; D003107:Colorectal Surgery / Q000379:methods; D005260:Female; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery*; D012187:Retroperitoneal Space; D016896:Treatment Outcome