[Disturbances in the cytokine system and oxidative stress in patients with chronic cardiac insufficiency].
A total of 99 patients with systolic chronic cardiac insufficiency (CCI) of NYHA functional class II-III (ejection fraction below 45%) were examined to evaluate cytokine activities, levels of oxidative stress markers and BNP fragment of brain natriuretic peptide. Patients aged 65-75 yr (group 2) had much higher levels of IL-1-beta, FNO-a, and malonic aldehyde than 26-56 year-old ones (group 1). The latter had a higher catalase activity. It is concluded that elderly patients with CCI develop more pronounced inflammatory reaction manifest as elevated C-reactive protein level, activated cytokine system, and endothelial dysfunction due to a longer history of the disease, higher frequency of ischemic etiology of CCI, and impaired NO-production in endothelium.
Iakhontov
D A
DA
Sukmanova
I A
IA
Dymova
D M
DM
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood*; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology; D005500:Follow-Up Studies; D054143:Heart Failure, Systolic / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D011379:Prognosis; D012720:Severity of Illness Index; D013318:Stroke Volume / Q000502:physiology; D055815:Young Adult
D015415:Biomarkers; D016207:Cytokines