The role of the PTEN gene in malignant gliomas.
This article focuses on the latest data about the role of the gene for phosphatase and tensin homologue located on chromosome 10 (PTEN) in malignant gliomas. PTEN acts as a tumour suppressor gene and plays a critical role in cell cycle progression, angiogenesis, migration, invasions and stem cell regulation. Furthermore, there is an interaction with other tumour suppressor genes. We discuss the role of miRNAs in modulating PTEN expression and also PTEN's role in the nucleus.
Alexiou
George A
GA
Department of Neurosurgery, University Hospital of Ioannia, Ioannina, Greece. alexiougrg@yahoo.gr
Voulgaris
Spyridon
S
D021581:Active Transport, Cell Nucleus; D000818:Animals; D001932:Brain Neoplasms / Q000235:genetics*; D002467:Cell Nucleus / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D005910:Glioma / Q000235:genetics*; D006801:Humans; D051059:PTEN Phosphohydrolase / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human