title: Multiple cranial neuropathy as the initial presentation of metastatic prostate adenocarcinoma: case report and review of literature.
abstract: The skull base is an atypical metastatic site for prostate carcinoma. It is usually encountered late in the disease process in patients with known advanced disease. However, skull base involvement causing cranial nerve palsies may rarely be the presenting sign of prostate carcinoma. Such patients may present to a number of specialties including neurosurgery and can pose a diagnostic challenge in the absence of lower urinary tract symptoms. Here, we describe an unusual case of prostate adenocarcinoma presenting as a central skull base tumour with multiple cranial neuropathy.
authors.affiliation: Department of Neurosurgery, Leeds General Infirmary, Great George Street, Leeds, LS1 3EX, UK. angeloskolias@gmail.com
authors.forename: Angelos G
authors.initials: AG
authors.lastname: Kolias
authors.forename: Christopher
authors.initials: C
authors.lastname: Derham
authors.forename: Kshitij
authors.initials: K
authors.lastname: Mankad
authors.forename: Harutomo
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Roddy
authors.initials: R
authors.lastname: O'Kane
authors.forename: Azzam
authors.initials: A
authors.lastname: Ismail
authors.forename: Nicholas I
authors.initials: NI
authors.lastname: Phillips
mesh_terms: D000368:Aged; D003388:Cranial Fossa, Posterior / Q000473:pathology / Q000503:physiopathology; D003389:Cranial Nerve Diseases / Q000175:diagnosis / Q000209:etiology / Q000473:pathology*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis / Q000175:diagnosis / Q000473:pathology*; D019291:Skull Base / Q000473:pathology / Q000503:physiopathology; D019292:Skull Base Neoplasms / Q000175:diagnosis / Q000556:secondary*