[Study on the levels of the bisphenol A, octylphenol, 4-nonylphenol in serum of precocious girls].
OBJECTIVE
To investigate the role of bisphenol A (BPA), octylphenol (OP), 4-nonylphenol(4-NP) causing precocious girls.


METHODS
The blood samples were collected from 110 cases of precocious girls and 100 cases of normal girls. The concentrations of BPA, OP, 4-NP in serum samples were measured by using high performance liquid chromatography (HPLC), the volume of the uteruse and ovary, the content of estradiol (E2) were determined at the same time. The contents of BPA, OP, 4-NP in blood serum of precocious girls and the indices of the target organs were analyed by using correlation.


RESULTS
BPA and, OP were detected in blood serum for 40.9% and 33.6% of precocious girls respectively, BPA and OP were detected for only 2% and 5% in normal girls respectively, 4-NP was detected for 24.54% of precocious girls and 3% of normal girls. The ratio of BPA, OP, 4-NP in blood serum of precocious girls was higher than normal girls respectively (P < 0.01), BPA in blood serum of precocious girls patients was positive correlation with the volume of the uterus (r = 0.557, P < 0.05), and positive correlation with volume of the ovary (r = 0.469, P < 0.01). OP in blood serum of precocious girls patients was positive correlation with the volume of uterus (r = 0.576, P < 0.05), positive correlation with volume of ovary (r = 0.676, P < 0.01).


CONCLUSIONS
Precocious girls patients were contaminated more severely than normal girls, and BPA, OP could influence the volume of the uterus and ovary, so it had some relationship with cause of precocious girls.
Qiao
Lili
L
Songjiang Centred Hospital, Shanghai 201600, China. qiaolili1976@163.com
Zheng
Lixing
L
Cai
Depei
D
D001559:Benzhydryl Compounds; D002648:Child; D002675:Child, Preschool; D052244:Endocrine Disruptors / Q000097:blood; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D006801:Humans; D010636:Phenols / Q000097:blood*; D011629:Puberty, Precocious / Q000097:blood / Q000139:chemically induced*; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D004785:Environmental Pollutants; D010636:Phenols; C474055:octylphenol; C041594:4-nonylphenol; C006780:bisphenol A; D000098826:Bisphenol A Compounds