title: Two cases of late-onset drug-induced lupus erythematosus caused by ticlopidine in elderly men.
abstract: We have experienced two cases of drug-induced lupus erythematosus caused by ticlopidine in the last three years. Both were late-onset cases (1 and 4 years) that occurred in elderly men (76 and 81 years old). The common features were fever, arthralgia, myalgia, serositis, and the presence of anti-histone autoantibodies. Because ticlopidine is widely used in elderly people with ischemic vascular disease, ticlopidine-induced lupus should be considered when patients taking ticlopidine present lupus-like symptoms.
authors.affiliation: Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Usui
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kiyama
authors.forename: Ran
authors.initials: R
authors.lastname: Nakashima
authors.forename: Naoichiro
authors.initials: N
authors.lastname: Yukawa
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kawabata
authors.forename: Takaki
authors.initials: T
authors.lastname: Nojima
authors.forename: Koichiro
authors.initials: K
authors.lastname: Ohmura
authors.forename: Takao
authors.initials: T
authors.lastname: Fujii
authors.forename: Tsuneyo
authors.initials: T
authors.lastname: Mimori
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D006657:Histones / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000276:immunology; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D013988:Ticlopidine / Q000009:adverse effects*
chemical_list: D001323:Autoantibodies; D006657:Histones; D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine