A novel structural motif and structural trees for proteins containing it.
In the present study, a novel structural motif that can be represented as a combination of the known betaalphabeta-unit and psi-motif is described and analyzed. In theory, there are four possible combinations of the motifs since each of them can exist in two forms, left-handed and right-handed. For this study, we have selected 140 nonhomologous proteins in which 158 combinations of such types have been found. The combination of the right-handed psi-motif and the right-handed betaalphabeta-unit has been shown to occur most often (87 cases out of 158) and the combination of the left-handed betaalphabeta-unit and the left-handed psi-motif does not occur at all. Three novel structural trees in which the commonly occurring combinations are taken as the root structures have been constructed.
Kargatov
A M
AM
Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, 142290, Russia.
Efimov
A V
AV
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D019295:Computational Biology; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*
D010455:Peptides; D011506:Proteins