Endoplasmic reticulum stress response as a potential therapeutic target in multiple sclerosis.
Multiple Sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system (CNS). Since current treatments are aimed at nonspecifically down-regulating inflammation and natural mechanisms of repair and remyelination within the CNS are inadequate for recovery of function, MS patients presently only have available treatments that delay symptom progression. The complex nature of this disease means that only multifaceted treatments hold the promise of a cure. Recent studies indicate that the ER stress response, a cellular pathway that allows a cell to survive and recover from a stressful event, could be elicited to help the myelin-generating and myelin-support cells of the CNS survive inflammatory insult.
Getts
Meghann Teague
MT
Department of Microbiology-Immunology and Interdepartmental Immunobiology, Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
Getts
Daniel R
DR
Kohm
Adam P
AP
Miller
Stephen D
SD