title: Radiation-induced cerebellar high-grade glioma accompanied by meningioma and cavernoma 29 years after the treatment of medulloblastoma: a case report.
abstract: Here, we report the case of a patient with cerebellar high-grade glioma that developed after the patient underwent treatment for medulloblastoma. A 34-year-old man visited our hospital with complaints of dizziness and truncal ataxia. Magnetic resonance image showed a cerebellar tumor with multiple cavernomas and two lesions that were suspected to be meningiomas. The cerebellar tumor was surgically removed. According to pathological examination, the tumor was a high-grade glioma that was positive for methylated O-6-methylguanine-DNA methyltransferase promoter. In the past, he had received radiotherapy at the age of 5, after which he was operated for desmoplastic medulloblastoma in his right cerebellar hemisphere. Seven years after the initial therapy, cavernoma-induced intracerebral hemorrhage of the right temporal lobe was noted. To our knowledge, this is the first case of radiation-induced double intracranial tumors accompanied by symptomatic cavernoma.
authors.affiliation: Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan.
authors.forename: Tomoya
authors.initials: T
authors.lastname: Kamide
authors.forename: Mitsutoshi
authors.initials: M
authors.lastname: Nakada
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Tomohide
authors.initials: T
authors.lastname: Suzuki
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Uchiyama
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Kijima
authors.forename: Jun-ichiro
authors.initials: J
authors.lastname: Hamada
mesh_terms: D000328:Adult; D002528:Cerebellar Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D019175:DNA Methylation; D015254:DNA Modification Methylases / Q000235:genetics; D045643:DNA Repair Enzymes / Q000235:genetics; D005910:Glioma / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D020786:Hemangioma, Cavernous, Central Nervous System / Q000209:etiology* / Q000235:genetics / Q000473:pathology; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy; D008577:Meningeal Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology; D008579:Meningioma / Q000209:etiology* / Q000235:genetics / Q000473:pathology*; D009381:Neoplasms, Radiation-Induced / Q000235:genetics / Q000473:pathology*; D016133:Polymerase Chain Reaction; D011401:Promoter Regions, Genetic / Q000235:genetics; D025521:Tumor Suppressor Proteins / Q000235:genetics
chemical_list: D025521:Tumor Suppressor Proteins; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes