[Study on correlation of JAK/STAT signal pathway with progression and prognosis in hepatocellular carcinoma].
OBJECTIVE
To investigate the expression of JAK/STAT signal pathway in human hepatocellular carcinoma, and to evaluate its clinical significance in the progression and prognosis in hepatocellular carcinoma.


METHODS
196 patients with hepatocellular carcinoma were examined for the expression of JAK-1 protein and STAT-3 protein by SABC immunohistochemistry.


RESULTS
The positive expression rates of JAK-1 protein and STAT-3 protein in patients with hepatocellular carcinoma were significantly higher than those in 20 cases of normal liver tissue (P=0.02 and 0.01, respectively). There was no significant relation between the positive expression rates of JAK-1 protein and STAT-3 protein and patients'sex, age, tumor size, and cirrhosis of the hepatocellular carcinoma tissues (all P>0.05). The JAK-1 protein and STAT-3 protein were expressed more frequently in hepatocellular carcinoma tissues with incomplete capsule (P=0.01 and 0.008, respectively), venous tumor emboli (both P=0.02), poorly differentiated (P=0.01 and 0.009, respectively) or clinical III-IV stage (P=0.02 and 0.008, respectively) than in those with complete capsule, no venous tumor emboli, maturely differentiated or clinical I-II stage. Cox proportional hazard regression model analysis indicated that the expression of JAK-1 protein and STAT-3 protein was significantly correlated with the prognosis of patients with hepatocellular carcinoma.


CONCLUSIONS
The results suggest that the over-expression of JAK/STAT signal pathway may be an important feature of hepatocellular carcinoma.
Zhang
Bin
B
Department of General Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China. zbpbzxl@sina.com.cn
Zhong
De-wu
DW
Wang
Qun-wei
QW
Miao
Xiong-ying
XY
Dai
Wei-dong
WD
Liu
Chun
C
Pan
Kai-hua
KH
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D016022:Case-Control Studies; D018450:Disease Progression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D053613:Janus Kinase 1 / Q000378:metabolism*; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D050796:STAT3 Transcription Factor / Q000378:metabolism*; D015398:Signal Transduction
D050796:STAT3 Transcription Factor; D053613:Janus Kinase 1