title: Rigiflex lithography-based nanodot arrays for localized surface plasmon resonance biosensors.
abstract: We present a facile and robust means of fabricating metallic nanodot arrays for localized surface plasmon resonance (LSPR) biosensors through the strategic coupling of a polymeric template prepared with rigiflex lithography and a subsequent metallization via electrodeposition. Rigiflex lithography provides the capability to realize large-scale nanosized features as well as process flexibility during contact molding. In addition, the electrodeposition process enables wet-based nanoscale metallization with high pattern fidelity and geometric controllability. Generated metallic nanodot arrays can be used as a general platform for LSPR biosensors via the sequential binding of chemicals and biomolecules. Extinction spectra of the corresponding LSPR signal are measured with UV-vis-NIR spectroscopy, from which the pattern size and shape dependence of LSPR are readily confirmed. The feasibility of a very sensitive biosensor is demonstrated by the targeted binding of human immunoglobulin G, yielding subnanomolar detection capability with high selectivity.
authors.affiliation: School of Chemical Engineering, Sungkyunkwan University, Suwon 440-746, Republic of Korea.
authors.forename: Dong Kyu
authors.initials: DK
authors.lastname: Park
authors.forename: Hye In
authors.initials: HI
authors.lastname: Kim
authors.forename: Jun Pyo
authors.initials: JP
authors.lastname: Kim
authors.forename: Je Seob
authors.initials: JS
authors.lastname: Park
authors.forename: Su Yeon
authors.initials: SY
authors.lastname: Lee
authors.forename: Seung-Man
authors.initials: SM
authors.lastname: Yang
authors.forename: Jeewon
authors.initials: J
authors.lastname: Lee
authors.forename: Chan-Hwa
authors.initials: CH
authors.lastname: Chung
authors.forename: Sang Jun
authors.initials: SJ
authors.lastname: Sim
authors.forename: Pil J
authors.initials: PJ
authors.lastname: Yoo
mesh_terms: D000327:Adsorption; D004595:Electroplating; D006046:Gold / Q000737:chemistry; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D011093:Polyethylene Terephthalates / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D020349:Surface Plasmon Resonance / Q000295:instrumentation* / Q000379:methods*
chemical_list: D007074:Immunoglobulin G; D011093:Polyethylene Terephthalates; D011108:Polymers; D006046:Gold