title: NSAID-induced colopathy. A case series.
abstract: The adverse effects of non-steroidal anti-inflammatory drugs (NSAIDs) on the upper gastrointestinal tract and small intestine are well established. The effect of such therapy on the large intestine, so called NSAID colopathy, is less well described. We present four such cases demonstrating the characteristic endoscopic findings. One case in particular is, to our knowledge, the first report of the natural history of this clinical entity, initially presenting with the acute picture of inflammation and ulceration with subsequent progression to the more chronic development of diaphragm-like fibrous strictures. NSAID-induced colonic damage is a clinically significant condition. Two of our patients presented with bloody diarrhoea while the other two patients developed symptomatic anaemia. With the increasing use of enteric coated and sustained release NSAID preparations this condition is likely to become more frequent. Increasing awareness of its clinical presentation and of its spectrum of endoscopic findings facilitates a more prompt diagnosis and appropriate treatment to be established.
authors.affiliation: Department of Gastroenterology, St. Luke's Hospital, Kilkenny, Ireland. aftabar@hotmail.com
authors.forename: Abdur R
authors.initials: AR
authors.lastname: Aftab
authors.forename: Fergal
authors.initials: F
authors.lastname: Donnellan
authors.forename: Faisal
authors.initials: F
authors.lastname: Zeb
authors.forename: David
authors.initials: D
authors.lastname: Kevans
authors.forename: Garret
authors.initials: G
authors.lastname: Cullen
authors.forename: Garry
authors.initials: G
authors.lastname: Courtney
mesh_terms: D000368:Aged; D018798:Anemia, Iron-Deficiency / Q000139:chemically induced* / Q000175:diagnosis; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001706:Biopsy; D003106:Colon / Q000187:drug effects* / Q000473:pathology; D003108:Colonic Diseases / Q000139:chemically induced* / Q000175:diagnosis; D003113:Colonoscopy; D003967:Diarrhea / Q000139:chemically induced* / Q000175:diagnosis; D004008:Diclofenac / Q000009:adverse effects*; D018450:Disease Progression; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D008875:Middle Aged; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac