New analogues of acyclovir--synthesis and biological activity.
New acyclovir esters with peptidomimetics were synthesized and evaluated in vitro for their antiviral activity against the replication of Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2). The influence of peptidomimetics containing oxazole and thiazolyl-thiazole moieties on the antiviral activity is also reported. The esters were synthesized using the coupling reagents N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC) and N,N-dimethyl-4-aminopyridine (DMAP) as a catalyst.
Stankova
Ivanka
I
Department of Chemistry, South-West University Neofit Rilski, Ivan Michailov Str. 66, Blagoevgrad 2700, Bulgaria. ivastankova@abv.bg
Schichkov
Stoyan
S
Kostova
Kalina
K
Galabov
Angel
A
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002234:Carbodiimides; D004952:Esters; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000254:growth & development; D011725:Pyridines; D014779:Virus Replication / Q000187:drug effects
C518491:1-ethyl-3-(3-(diethylamino)propyl)carbodiimide; C417980:4-(dimethylamine)pyridine; D000998:Antiviral Agents; D002234:Carbodiimides; D004952:Esters; D011725:Pyridines; D000212:Acyclovir