Regulation and role of organic anion-transporting polypeptides (OATPs) in drug delivery at the choroid plexus.
The organic anion-transporting polypeptides (rodents: Oatps; human: OATPs) belong to the growing family of organic anion/prostaglandin transporters and are important components of the active efflux transport system at the choroid plexus epithelial cells. OATPs facilitate the elimination of xenobiotics and endogenous waste from the cerebrospinal fluid and prevent waste accumulation in the central nervous system (CNS). This review summarizes the structures, regulations and roles of Oatps/OATPs at the choroid plexus in drug delivery to the CNS.
Zhang
Hao
H
Department of Pharmacology, School of Pharmaceutical Sciences, Shandong University, 44 WenHuaXi Road, Jinan 250012, China.
Song
Yu-Ning
YN
Liu
Wei-Guo
WG
Guo
Xiu-Li
XL
Yu
Lu-Gang
LG
D000818:Animals; D002831:Choroid Plexus / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods; D006801:Humans; D027361:Organic Anion Transporters / Q000145:classification / Q000235:genetics / Q000378:metabolism*; D021381:Protein Transport; D014018:Tissue Distribution
D027361:Organic Anion Transporters