Orphan nuclear receptors as targets for drug development.
Orphan nuclear receptors regulate diverse biological processes. These important molecules are ligand-activated transcription factors that act as natural sensors for a wide range of steroid hormones and xenobiotic ligands. Because of their importance in regulating various novel signaling pathways, recent research has focused on identifying xenobiotics targeting these receptors for the treatment of multiple human diseases. In this review, we will highlight these receptors in several physiologic and pathophysiologic actions and demonstrate how their functions can be exploited for the successful development of newer drugs.
Mukherjee
Subhajit
S
Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Chanin 302-D1, Bronx, New York 10461, USA.
Mani
Sridhar
S
D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D008024:Ligands; D008954:Models, Biological; D057093:Orphan Nuclear Receptors / Q000502:physiology
D008024:Ligands; D057093:Orphan Nuclear Receptors