[Mineral and bone disturbances associated with chronic kidney disease].
In the course of chronic kidney disease (CKD) comes to the disturbances in mineral and bone metabolism and extra-skeletal calcification. In subsequent stages of CKD, these processes intensify, leading to a deterioration in the quality of life and disability. They are also a major cause of morbidity and mortality from cardiovascular causes in CKD. In 2005, the Organization of Kidney Disease: Improving Global Outcomes (KIDGO), proposed replacing the term Renal Osteodystrophy in mineral and bone complications CKD (chronic kidney disease mineral and bone related disorders; CKD-MBD) as the disorder is not confined to the skeleton. CKD-MBD is manifested by the presence of changes in laboratory tests (corrected serum calcium, organic phosphate, parathyroid hormone, concentrations of vitamin D derivatives), changes in bone (bone metabolism, bone mineralization and trabecular bone volume), the occurrence of calcifications in the soft tissues and the arterial vessels.
Suchowierska
Ewa
E
Uniwersytet Medyczny w Białymstoku, Klinika Nefrologii i Transplantologii. esuch@poczta.onet.pl
Myśliwiec
Michał
M
D001847:Bone Diseases / Q000209:etiology; D001842:Bone and Bones / Q000378:metabolism; D002114:Calcinosis / Q000209:etiology; D002318:Cardiovascular Diseases / Q000150:complications; D002908:Chronic Disease; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D006801:Humans; D007674:Kidney Diseases / Q000150:complications; D053245:RANK Ligand / Q000378:metabolism; D009626:Terminology as Topic
D053245:RANK Ligand; C505688:TNFSF11 protein, human