title: One-pot synthesis of substituted di-hydrofurans from Lewis base-catalyzed three-component condensation.
abstract: A one-pot synthesis of substituted dihydrofurans was developed through a Lewis base-catalyzed three-component cascade condensation between nitroalkenes, aldehydes, and 1,3-dicarbonyl compounds. The desired cyclization products were prepared with a large substrate scope (22 examples) and excellent diastereoselectivity (only trans isomers) in good to excellent yields (up to 95%).
authors.affiliation: C. Eugene Bennett Department of Chemistry, West Virginia University, Morgantown, West Virginia 26506, USA.
authors.forename: Cheng
authors.initials: C
authors.lastname: Zhong
authors.forename: Tao
authors.initials: T
authors.lastname: Liao
authors.forename: Odbadrakh
authors.initials: O
authors.lastname: Tuguldur
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Shi