New medicines for malaria.
Development of new medicines for malaria is a challenging and important topic of applied research because malarial parasites rapidly adapt to man-made interventions. Best studied examples are widely used drugs such as chloroquine, sulfadoxin-pyrimethamine (SP), and, recently, artemisinins; all of them can lose efficacy after large-scale introduction. In addition to drugs, malaria vaccines re-emerged on the agenda of funding bodies and research institutions after a period of quietness and desperation. This time the communities' aims are high: a registered and effective malaria-vaccine. So far, only one candidate shows modest efficacy, a quantum leap in malaria vaccine research, whereas others have not met the high expectations. In this overview, I will summarize basic thoughts and principles behind our work and illustrate them with examples of current projects of my group.
Mordmüller
Benjamin
B
Institut für Tropenmedizin, Eberhard Karls Universität Tübingen, Tübingen, Germany. benjamin.mordmueller@uni-tuebingen.de
D000962:Antimalarials / Q000627:therapeutic use*; D015195:Drug Design; D006801:Humans; D008288:Malaria / Q000517:prevention & control*; D017780:Malaria Vaccines / Q000627:therapeutic use*
D000962:Antimalarials; D017780:Malaria Vaccines