Drug release behavior from nanoporous anodic aluminum oxide.
In this study, we developed a new drug delivery system using anodic oxidation. The growth of a porous oxide layer on aluminum under anodic bias in various electrolytes has been studied for more than 40 years. Anodic Aluminum Oxide (AAO) has many uniform nanopores on its surface. This nanoporous surface can be used for drug storage. The effects of the diameter and depth of the AAO on the release characteristics of a drug were investigated. Paclitaxel was used for the drug loading and release test. Paclitaxel was loaded on the inside of the AAO by ultrasonication. The amount of the drug released from the AAO was analyzed by high performance liquid chromatography (HPLC). The pore size did not affect the drug release behavior. However, the depth of the pores had a significant influence on the release rate of the drug.
Kwak
Dae-Hyun
DH
School of Advanced Materials Science and Engineering, Sungkyunkwan University, Suwon, 440-746, Korea.
Yoo
Ji-Beom
JB
Kim
Deug Joong
DJ
D000537:Aluminum Oxide / Q000737:chemistry* / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D016503:Drug Delivery Systems / Q000379:methods*; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000008:administration & dosage / Q000737:chemistry* / Q000648:ultrastructure; D017239:Paclitaxel / Q000737:chemistry* / Q000493:pharmacokinetics; D010316:Particle Size; D016062:Porosity
D000537:Aluminum Oxide; D017239:Paclitaxel