title: Pathophysiology and antioxidant status of patients with fibromyalgia.
abstract: Fibromyalgia syndrome (FMS) is characterized by systemic pain of unknown etiology and is often accompanied by various psychological symptoms. Research on different parameters in fibromyalgia (FM) indicates that multifactors are involved in its pathophysiology; such as genetic factors, substance P, serotonin, hypothalamic pituitary adrenal axis (HPA), muscles metabolic dysfunction, reactive oxygen species (ROS) and reactive nitrogen species (RNS). Oxidative stress has also been implicated in the pathophysiology of FM; therefore, supplementation with antioxidants may be important in modulation of the effects of ROS in patients with FM.
authors.affiliation: Zoology Department, G. C. University, Lahore, 54000, Pakistan.
authors.forename: Riffat
authors.initials: R
authors.lastname: Iqbal
authors.forename: M S
authors.initials: MS
authors.lastname: Mughal
authors.forename: Najma
authors.initials: N
authors.lastname: Arshad
authors.forename: Muhammad
authors.initials: M
authors.lastname: Arshad
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism* / Q000627:therapeutic use; D015673:Fatigue Syndrome, Chronic / Q000503:physiopathology; D005356:Fibromyalgia / Q000235:genetics / Q000503:physiopathology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D051379:Mice; D018384:Oxidative Stress; D010146:Pain / Q000378:metabolism / Q000503:physiopathology; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D013373:Substance P / Q000378:metabolism
chemical_list: D000975:Antioxidants; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D013373:Substance P