title: Gliosis in the amygdala following myocardial infarction in the rat.
abstract: We observed gliosis with cell death in the rat amygdala 3 and 14 days after myocardial infarction (MI). Cresyl violet-positive neurons had condensed cytoplasm, and Fluoro-Jade B-positive cells were detected in the amygdala 14 days, not 3 days, after MI. Only a few glial fibrillary acidic protein (GFAP)-immunoreactive astrocytes and ionized calcium-binding adapter molecule 1 (Iba-1)-immunoreactive microglia showed activated form; hypertrophied cytoplasm, and highly ramified and retracted processes of astrocytes and microglia in the amygdala at 3 days after MI, respectively. At 14 days after MI, many astrocytes and most of microglia showed activated forms. These results suggest that MI may induce neuronal death and reactive gliosis in the amygdala.
authors.affiliation: Department of Pediatrics, Chuncheon Sacred Heart Hospital, College of Medicine, Hallym University, Chuncheon, South Korea.
authors.forename: Eunjoo
authors.initials: E
authors.lastname: Bae
authors.forename: In Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Ki-Yeon
authors.initials: KY
authors.lastname: Yoo
authors.forename: Tae Hee
authors.initials: TH
authors.lastname: Han
authors.forename: Choong Hyun
authors.initials: CH
authors.lastname: Lee
authors.forename: Jung Hoon
authors.initials: JH
authors.lastname: Choi
authors.forename: Sun Shin
authors.initials: SS
authors.lastname: Yi
authors.forename: So Yeong
authors.initials: SY
authors.lastname: Lee
authors.forename: Pan Dong
authors.initials: PD
authors.lastname: Ryu
authors.forename: Yeo Sung
authors.initials: YS
authors.lastname: Yoon
authors.forename: Moo-Ho
authors.initials: MH
authors.lastname: Won
mesh_terms: D000679:Amygdala / Q000276:immunology / Q000473:pathology*; D000818:Animals; D001253:Astrocytes / Q000473:pathology; D001402:B-Lymphocytes / Q000473:pathology; D002135:Calcium-Binding Proteins / Q000032:analysis; D016923:Cell Death; D003593:Cytoplasm / Q000473:pathology; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D005911:Gliosis / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D008285:Major Histocompatibility Complex; D008840:Microfilament Proteins; D009203:Myocardial Infarction / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D009206:Myocardium / Q000473:pathology; D009474:Neurons / Q000276:immunology / Q000473:pathology; D051381:Rats; D013997:Time Factors
chemical_list: C100745:Aif1 protein, rat; D002135:Calcium-Binding Proteins; D005904:Glial Fibrillary Acidic Protein; D008840:Microfilament Proteins