title: Oocyte maturation failure: a syndrome of bad eggs.
abstract: To show that disruption of meiotic competence results in cell cycle arrest, and the production of immature oocytes that are not capable of fertilization. Through an extensive review of animal studies and clinical case reports, we define the syndrome of oocyte maturation failure as a distinct oocyte disorder, present a classification system based on clinical parameters, and discuss the potential molecular origins for the disease.
authors.affiliation: Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
authors.forename: Stephanie
authors.initials: S
authors.lastname: Beall
authors.forename: Carol
authors.initials: C
authors.lastname: Brenner
authors.forename: James
authors.initials: J
authors.lastname: Segars
mesh_terms: D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods; D002454:Cell Differentiation / Q000502:physiology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000473:pathology*; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D009865:Oocytes / Q000166:cytology* / Q000502:physiology*; D009866:Oogenesis / Q000502:physiology; D027724:Reproductive Techniques, Assisted; D013577:Syndrome; D017211:Treatment Failure; D015053:Zygote / Q000166:cytology / Q000473:pathology*