title: Heterocyclic cycloalkanol ethylamines as norepinephrine reuptake inhibitors.
abstract: A series of heterocyclic cycloalkanol ethylamines have been prepared to expand our norepinephrine reuptake inhibitor (NRI) program. Synthesis of a variety of heterocycles identified (+)-S-21, a potent NRI efficacious in an animal model for thermoregulatory dysfunction.
authors.affiliation: Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. sabatuj@wyeth.com
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Sabatucci
authors.forename: Paige E
authors.initials: PE
authors.lastname: Mahaney
authors.forename: Jennifer
authors.initials: J
authors.lastname: Leiter
authors.forename: Grace
authors.initials: G
authors.lastname: Johnston
authors.forename: Kevin
authors.initials: K
authors.lastname: Burroughs
authors.forename: Scott
authors.initials: S
authors.lastname: Cosmi
authors.forename: Yingru
authors.initials: Y
authors.lastname: Zhang
authors.forename: Douglas
authors.initials: D
authors.lastname: Ho
authors.forename: Darlene C
authors.initials: DC
authors.lastname: Deecher
authors.forename: Eugene
authors.initials: E
authors.lastname: Trybulski
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D005021:Ethylamines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D008968:Molecular Conformation; D014179:Neurotransmitter Uptake Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D009638:Norepinephrine / Q000737:chemistry / Q000378:metabolism*; D010879:Piperazines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D005021:Ethylamines; D014179:Neurotransmitter Uptake Inhibitors; D010879:Piperazines; D013876:Thiophenes; D009638:Norepinephrine