title: Lupus anticoagulant, antiphospholipid syndrome and cardiac surgery.
abstract: The presence of lupus anticoagulant and the related condition antiphospholipid syndrome present a challenge in cardiac surgery where measured anticoagulation may not reflect the in vivo patient status of hypercoagulation. We report the successful management of a patient with lupus anticoagulant presenting for aortic valve replacement and coronary revascularisation. We used heparin for anticoagulation, specialised additional tests of anticoagulation and a reduced protamine dose. We also used tranexamic acid. The clinical problems with anticoagulation in patients with lupus anticoagulant include anticoagulant choice, measurement of adequate anticoagulation, antifibrinolytic usage, protamine dosing and blood product transfusion.
authors.affiliation: Green Lane Department of Cardiothoracic Anaesthesia, Auckland City Hospital, Auckland, New Zealand. bcartwright@adhb.govt.nz
authors.forename: B L
authors.initials: BL
authors.lastname: Cartwright
authors.forename: M
authors.initials: M
authors.lastname: Bean
authors.forename: J O
authors.initials: JO
authors.lastname: Cooper
mesh_terms: D000368:Aged; D016736:Antiphospholipid Syndrome / Q000097:blood*; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood*; D008297:Male; D014148:Tranexamic Acid / Q000627:therapeutic use
chemical_list: D016682:Lupus Coagulation Inhibitor; D014148:Tranexamic Acid; D006493:Heparin