[Studies on inhibitive effect of low-voltage electrochemotherapy on head and neck cancer-bearing nude mice].
OBJECTIVE
To analyse the therapie effect of low-voltage electrochemotherapy (EP) on the head and neck cancer.


METHODS
YCU-N861 human head and neck cancer cells were subcutaneously inoculated in the neck of nude mice to establish tumor-bearing models. Then the mice were treated with bleomycin (BLM, 20 microg per mouse), accompanied with electric stimulation (50 V or 100 V).


RESULTS
BLM treatment applied with EP can significantly inhibit the proliferation of tumor cells than BLM or EP treatment separately (P < 0.01). The tumor volume, the mitotic index (MI) and the labeling index (LI) of Ki67 in BLM+EP group were all obviously decreased than BLM group, EP group and control group (P < 0.01).


CONCLUSIONS
Low-voltage electrochemotherapy can offer promising method in the local treatment of head and neck cancer.
Wang
Xuefeng
X
Department of Otorhinolaryngology, the First Affiliated Hospital, Liaoning Medical University, Jinzhou,121001, China. jzswang@126.com
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage / Q000627:therapeutic use; D045744:Cell Line, Tumor; D053672:Electrochemotherapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy / Q000628:therapy*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation
D000964:Antimetabolites, Antineoplastic; D001761:Bleomycin