Antitumor activity of methylan polysaccharide derivatives.
Methylan polysaccharide derivatives were prepared by dialkylaminoalkylation and reductive amination followed by quaternization. Their antitumor activity was investigated and a relationship between structure and activity is suggested. For quaternized DEAE-methylan at only 75 mug ml(-1), tumor cell proliferation was suppressed by 58-84% in three cell lines tested in the order Colo < Hela < HepG2.
Ramachandran
Priyadharshini
P
Department of Chemical Enginering, Konkuk University, Hwayang-Dong, Kwangjin-Ku, Seoul, 143-701, Korea.
Jeya
Marimuthu
M
Moon
Hee-Jung
HJ
Lee
Kyoung-Mi
KM
Kim
In-Won
IW
Kim
Jung-Hoe
JH
Lee
Jung-Kul
JK
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D015394:Molecular Structure; D011134:Polysaccharides / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D011134:Polysaccharides