title: Metformin, naltrexone, or the combination of prednisolone and antiandrogenic oral contraceptives as first-line therapy in hyperinsulinemic women with polycystic ovary syndrome.
abstract: To compare the short-term effects of metformin (M), naltrexone (N), and a combination of OC and prednisolone (OC/Pr) on the metabolic state and the ovarian function of PCOS women, we randomized 29 women to a 3-month course of therapy. We observed significant improvements in hyperandrogenemia and ovulation rates in PCOS women of all three groups, in the absence of changes in the metabolic state, suggesting that insulin resistance in PCOS patients is only one of several factors leading to hyperandrogenemic ovarian failure.
authors.affiliation: Department of Gynecologic Endocrinology and Reproductive Medicine, Medical University of Innsbruck, Innsbruck, Austria.
authors.forename: Dijana
authors.initials: D
authors.lastname: Hadžiomerović-Pekić
authors.forename: Ludwig
authors.initials: L
authors.lastname: Wildt
authors.forename: Jürgen Michael
authors.initials: JM
authors.lastname: Weiss
authors.forename: Kay
authors.initials: K
authors.lastname: Moeller
authors.forename: Verena
authors.initials: V
authors.lastname: Mattle
authors.forename: Beata E
authors.initials: BE
authors.lastname: Seeber
mesh_terms: D000293:Adolescent; D000328:Adult; D000726:Androgen Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D003276:Contraceptives, Oral / Q000008:administration & dosage* / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects; D008687:Metformin / Q000008:administration & dosage* / Q000009:adverse effects; D009271:Naltrexone / Q000008:administration & dosage* / Q000009:adverse effects; D020360:Neoadjuvant Therapy; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage* / Q000009:adverse effects; D055815:Young Adult
chemical_list: D000726:Androgen Antagonists; D000970:Antineoplastic Agents; D003276:Contraceptives, Oral; D005938:Glucocorticoids; D007004:Hypoglycemic Agents; D009271:Naltrexone; D008687:Metformin; D011239:Prednisolone