Does estrogen directly modulate anti-müllerian hormone secretion in women?
OBJECTIVE
To investigate whether estrogen may modulate anti-müllerian hormone (AMH) expression in women.


METHODS
Prospective analysis.


METHODS
Fertility clinic of tertiary university hospital.


METHODS
Cycling infertile women.


METHODS
Blood samples were taken at the early, middle, and late follicular phase in five groups: spontaneous cycle (n=10), ovulation induction with clomiphene-citrate (n=15) or gonadotropins (n=9), controlled ovarian hyperstimulation for IVF (COH-IVF; n=10) and in women who were treated with exogenous E2 for frozen-thawed embryo-transfer (FET) with no follicular development (n=20).


METHODS
AMH and E2 serum levels.


RESULTS
Basal serum AMH and E2 levels were similar in all groups. AMH levels were stable in all women during the follicular phase except for significant reduction in the COH-IVF group. In women in the FET group with high E2 levels, comparable to the COH-IVF group, AMH levels remained stable.


CONCLUSIONS
In women, estrogen does not appear to have a direct role in AMH regulation.
Liberty
Gad
G
Department of Obstetrics and Gynecology, Shaare Zedek Medical Center, Hebrew University, Jeusalem, Israel.
Ben-Chetrit
Avraham
A
Margalioth
Ehud J
EJ
Hyman
Jordana H
JH
Galoyan
Narine
N
Eldar-Geva
Talia
T
D000293:Adolescent; D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood / Q000378:metabolism*; D004334:Drug Administration Schedule; D004967:Estrogens / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007246:Infertility / Q000097:blood / Q000628:therapy; D008597:Menstrual Cycle / Q000097:blood / Q000187:drug effects; D010062:Ovulation Induction; D013997:Time Factors; D055815:Young Adult
D004967:Estrogens; D054304:Anti-Mullerian Hormone