title: The rs1800629 polymorphism in the TNF gene interacts with physical activity on the changes in C-reactive protein levels in the Finnish Diabetes Prevention Study.
abstract: Physical activity exerts anti-inflammatory effects, but genetic variation may modify its influence. In particular, the rs1800629 single-nucleotide polymorphism (SNP) in the tumor necrosis factor ( TNF) gene and the rs1800795 SNP in the interleukin-6 ( IL6) gene have been found to modify the effect of exercise training on circulating levels of C-reactive protein (CRP) and IL-6, respectively. We assessed whether rs1800629 and rs1800795 modified the effect of moderate-to-vigorous physical activity on changes in serum levels of high-sensitivity CRP and IL-6 in the Finnish Diabetes Prevention Study (DPS). Genotype and 1-year data on changes in physical activity, serum CRP and IL-6 were available for 390 overweight subjects with impaired glucose tolerance. The rs1800629 SNP in TNF interacted with the 1-year change in moderate-to-vigorous physical activity on changes in CRP among those who had high (≥3 mg/L) baseline CRP levels ( P = 0.034 for interaction). Carriers of the GG genotype showed a greater decrease in CRP with increasing physical activity than the individuals with the A allele. No interaction between the rs1800795 SNP in IL6 and changes in moderate-to-vigorous physical activity on the 1-year change in serum IL-6 was found. In conclusion, the rs1800629 SNP in the TNF gene may modify the effect of moderate-to-vigorous physical activity on serum levels of CRP.
authors.affiliation: Institute of Biomedicine, Physiology, University of Kuopio, Kuopio, Finland. tuomas.kilpelainen@mrc-epid.cam.ac.uk
authors.forename: T O
authors.initials: TO
authors.lastname: Kilpeläinen
authors.forename: D E
authors.initials: DE
authors.lastname: Laaksonen
authors.forename: T A
authors.initials: TA
authors.lastname: Lakka
authors.forename: C
authors.initials: C
authors.lastname: Herder
authors.forename: W
authors.initials: W
authors.lastname: Koenig
authors.forename: J
authors.initials: J
authors.lastname: Lindström
authors.forename: J G
authors.initials: JG
authors.lastname: Eriksson
authors.forename: M
authors.initials: M
authors.lastname: Uusitupa
authors.forename: H
authors.initials: H
authors.lastname: Kolb
authors.forename: M
authors.initials: M
authors.lastname: Laakso
authors.forename: J
authors.initials: J
authors.lastname: Tuomilehto
mesh_terms: D002097:C-Reactive Protein / Q000032:analysis*; D003924:Diabetes Mellitus, Type 2 / Q000517:prevention & control; D005260:Female; D005387:Finland; D056726:Genetic Association Studies; D018149:Glucose Intolerance; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D050177:Overweight / Q000097:blood* / Q000628:therapy*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein