Preparation of syn-tertiary homoallylic alcohols utilizing allenyltitanocenes generated by reductive titanation of gamma-trimethylsilylpropargylic carbonates.
syn-Tertiary homoallylic alcohols were obtained by the reaction of alpha-silylallenyltitanocenes generated by the reductive titanation of gamma-silylpropargylic carbonates with Cp(2)Ti[P(OEt)(3)](2) with ketones and following desilylation and partial hydrogenation. High diastereoselectivity was observed when aromatic and alpha,beta-unsaturated ketones were employed.
Yatsumonji
Yasutaka
Y
Department of Applied Chemistry, Graduate School of Engineering, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan.
Sugita
Takenori
T
Tsubouchi
Akira
A
Takeda
Takeshi
T