title: Eukaryotic chromosome DNA replication: where, when, and how?
abstract: DNA replication is central to cell proliferation. Studies in the past six decades since the proposal of a semiconservative mode of DNA replication have confirmed the high degree of conservation of the basic machinery of DNA replication from prokaryotes to eukaryotes. However, the need for replication of a substantially longer segment of DNA in coordination with various internal and external signals in eukaryotic cells has led to more complex and versatile regulatory strategies. The replication program in higher eukaryotes is under a dynamic and plastic regulation within a single cell, or within the cell population, or during development. We review here various regulatory mechanisms that control the replication program in eukaryotes and discuss future directions in this dynamic field.
authors.affiliation: Genome Dynamics Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan. masai-hs@igakuken.or.jp
authors.forename: Hisao
authors.initials: H
authors.lastname: Masai
authors.forename: Seiji
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Zhiying
authors.initials: Z
authors.lastname: You
authors.forename: Naoko
authors.initials: N
authors.lastname: Yoshizawa-Sugata
authors.forename: Masako
authors.initials: M
authors.lastname: Oda
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000378:metabolism*; D004261:DNA Replication; D006801:Humans; D018741:Replication Origin; D016196:S Phase