title: Perfusion magnetic resonance imaging of the liver.
abstract: Perfusion magnetic resonance imaging (MRI) studies quantify the microcirculatory status of liver parenchyma and liver lesions, and can be used for the detection of liver metastases, assessing the effectiveness of anti-angiogenic therapy, evaluating tumor viability after anti-cancer therapy or ablation, and diagnosis of liver cirrhosis and its severity. In this review, we discuss the basic concepts of perfusion MRI using tracer kinetic modeling, the common kinetic models applied for analyses, the MR scanning techniques, methods of data processing, and evidence that supports its use from published clinical and research studies. Technical standardization and further studies will help to establish and validate perfusion MRI as a clinical imaging modality.
authors.affiliation: Department of Oncologic Imaging, National Cancer Centre, Singapore 169610, Singapore.
authors.forename: Choon Hua
authors.initials: CH
authors.lastname: Thng
authors.forename: Tong San
authors.initials: TS
authors.lastname: Koh
authors.forename: David J
authors.initials: DJ
authors.lastname: Collins
authors.forename: Dow Mu
authors.initials: DM
authors.lastname: Koh
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000098:blood supply / Q000473:pathology* / Q000502:physiology; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000473:pathology; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D008954:Models, Biological; D010477:Perfusion; D015203:Reproducibility of Results; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D003287:Contrast Media