title: Nhatrangins A and B, aplysiatoxin-related metabolites from the marine cyanobacterium Lyngbya majuscula from Vietnam.
abstract: Two polyketide metabolites, nhatrangins A (1) and B (2), were isolated from a Vietnamese collection of Lyngbya majuscula. These compounds are related to the aplysiatoxin series of metabolites, which have also been isolated from this species of marine cyanobacterium. The use of 900 MHz cryoprobe NMR allowed the elucidation of the 2D structure of 1 from approximately 0.3 mg of compound. LC-MS analysis was utilized to direct the isolation of additional material as well as the isolation of 2. Conformational analysis was completed using J-based coupling constant analysis and selective NOE experiments.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, 833 S. Wood Street, Chicago, Illinois 60612, USA.
authors.forename: George E
authors.initials: GE
authors.lastname: Chlipala
authors.forename: Huu Tri
authors.initials: HT
authors.lastname: Pham
authors.forename: Van Hung
authors.initials: VH
authors.lastname: Nguyen
authors.forename: Aleksej
authors.initials: A
authors.lastname: Krunic
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Shim
authors.forename: D Doel
authors.initials: DD
authors.lastname: Soejarto
authors.forename: Jimmy
authors.initials: J
authors.lastname: Orjala
mesh_terms: D000458:Cyanobacteria / Q000737:chemistry; D008235:Lyngbya Toxins / Q000737:chemistry / Q000302:isolation & purification*; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014744:Vietnam
chemical_list: D008235:Lyngbya Toxins; C549735:nhatrangin A; C549736:nhatrangin B; C006610:aplysiatoxin