Role of extracellular DNA in initial bacterial adhesion and surface aggregation.
Extracellular DNA (eDNA) is an important component of the biofilm matrix. We show that removal of eDNA from Gram-positive bacteria reduces initial adhesion to and aggregation of bacteria on surfaces. Thermodynamic analyses indicated that eDNA introduces favorable acid-base interactions, explaining the effect of eDNA on aggregation and adhesion to the surface.
Das
Theerthankar
T
Department of Biomedical Engineering, University Medical Center Groningen, Groningen, Netherlands.
Sharma
Prashant K
PK
Busscher
Henk J
HJ
van der Mei
Henny C
HC
Krom
Bastiaan P
BP
D001422:Bacterial Adhesion / Q000235:genetics / Q000502:physiology*; D018441:Biofilms; D004247:DNA / Q000378:metabolism*; D006094:Gram-Positive Bacteria / Q000235:genetics / Q000254:growth & development* / Q000378:metabolism*; D057927:Hydrophobic and Hydrophilic Interactions; D009154:Mutation
D004247:DNA