title: A CROC stronger than ROC: measuring, visualizing and optimizing early retrieval.
abstract: BACKGROUND
  The performance of classifiers is often assessed using Receiver Operating Characteristic ROC [or (AC) accumulation curve or enrichment curve] curves and the corresponding areas under the curves (AUCs). However, in many fundamental problems ranging from information retrieval to drug discovery, only the very top of the ranked list of predictions is of any interest and ROCs and AUCs are not very useful. New metrics, visualizations and optimization tools are needed to address this 'early retrieval' problem.
  
  
  RESULTS
  To address the early retrieval problem, we develop the general concentrated ROC (CROC) framework. In this framework, any relevant portion of the ROC (or AC) curve is magnified smoothly by an appropriate continuous transformation of the coordinates with a corresponding magnification factor. Appropriate families of magnification functions confined to the unit square are derived and their properties are analyzed together with the resulting CROC curves. The area under the CROC curve (AUC[CROC]) can be used to assess early retrieval. The general framework is demonstrated on a drug discovery problem and used to discriminate more accurately the early retrieval performance of five different predictors. From this framework, we propose a novel metric and visualization-the CROC(exp), an exponential transform of the ROC curve-as an alternative to other methods. The CROC(exp) provides a principled, flexible and effective way for measuring and visualizing early retrieval performance with excellent statistical power. Corresponding methods for optimizing early retrieval are also described in the Appendix.
  
  
  BACKGROUND
  Datasets are publicly available. Python code and command-line utilities implementing CROC curves and metrics are available at http://pypi.python.org/pypi/CROC/ CONTACT: pfbaldi@ics.uci.edu
authors.affiliation: Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University, St. Louis, MO 63110, USA.
authors.forename: S Joshua
authors.initials: SJ
authors.lastname: Swamidass
authors.forename: Chloé-Agathe
authors.initials: CA
authors.lastname: Azencott
authors.forename: Kenny
authors.initials: K
authors.lastname: Daily
authors.forename: Pierre
authors.initials: P
authors.lastname: Baldi
mesh_terms: D000465:Algorithms; D019540:Area Under Curve; D019295:Computational Biology / Q000379:methods*; D055808:Drug Discovery; D015233:Models, Statistical; D012372:ROC Curve; D012984:Software