PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.
Schaller
Michael D
MD
Department of Biochemistry, West Virginia University, Morgantown, WV, USA.
Frisch
Steven M
SM
D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects*; D002352:Carrier Proteins / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D051416:Focal Adhesion Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D051379:Mice; D011485:Protein Binding / Q000187:drug effects; D047428:Protein Kinase Inhibitors / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects; D018874:Spheroids, Cellular / Q000187:drug effects; D014407:Tumor Cells, Cultured
D000631:Aminopyridines; D000970:Antineoplastic Agents; D002352:Carrier Proteins; C559284:PND 1186; D047428:Protein Kinase Inhibitors; D051416:Focal Adhesion Protein-Tyrosine Kinases