2-hydroxyglutarate accumulation caused by IDH mutation is involved in the formation of malignant gliomas.
Sonoda
Yukihiko
Y
Tominaga
Teiji
T
D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism*; D005910:Glioma / Q000235:genetics* / Q000378:metabolism*; D005977:Glutarates / Q000378:metabolism*; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D009154:Mutation
D005977:Glutarates; C019417:alpha-hydroxyglutarate; C538784:IDH2 protein, human; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human