title: Association of 22 cytokine gene polymorphisms with tuberculosis in Macedonians.
abstract: OBJECTIVE
  To examine the possible role of 22 cytokine gene polymorphisms in host susceptibility to or protection against tuberculosis (TB) in Macedonians.
  
  
  METHODS
  301 healthy unrelated individuals and 75 patients with pulmonary TB were studied. Cytokine genotyping was performed by PCR with sequence-specific priming (PCR-SSP) (Heidelberg kit).
  
  
  RESULTS
  TNF-alpha-238/G, IL-1R psti1970/C, IL-1beta + 3962/T:T, IL-4-1098/T:T, IFNgamma utr5644/A:A, IL-10-1082/G:G, IL-4-590/C:C, IL-10/ATC, IL-4/TCT, IL-4/TCC, IL-10/ATC:GCC, IL-4/TCT:TTT, IL-4/TCC:TTC, IL-10/GCC:GCC and IL-4/TCC:TCC were positively associated with TB, while protective association was identified for IL-4-098/G, IL-1beta + 3962/C, IFNgamma utr5644/T, IL-1beta + 3962/C:T, IL-4-1098/G:T, IL-4-590/C:T, IFNgamma utr5644/A:T, IL-4/GCC, IL-4/TTC and IL-4/GCC:TTC.
  
  
  CONCLUSIONS
  These results suggest that some cytokine polymorphisms are significantly associated and affect host susceptibility/resistance to TB in Macedonians.
authors.affiliation: Institute of Immunobiology and Human Genetics, Faculty of Medicine, University St. Kiril and Metodij, Skopje, Republic of Macedonia.
authors.forename: Dejan
authors.initials: D
authors.lastname: Trajkov
authors.forename: Mirjana
authors.initials: M
authors.lastname: Trajchevska
authors.forename: Todor
authors.initials: T
authors.lastname: Arsov
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Petlichkovski
authors.forename: Ana
authors.initials: A
authors.lastname: Strezova
authors.forename: Olivija
authors.initials: O
authors.lastname: Efinska-Mladenovska
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Sandevski
authors.forename: Mirko
authors.initials: M
authors.lastname: Spiroski
mesh_terms: D000328:Adult; D016207:Cytokines / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006115:Greece; D006239:Haplotypes; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics; D007378:Interleukins / Q000235:genetics; D008875:Middle Aged; D011110:Polymorphism, Genetic; D014376:Tuberculosis / Q000453:epidemiology*
chemical_list: D016207:Cytokines; D007376:Interleukin-2; D007378:Interleukins