title: Letterer-Siwe disease associated with chronic myelomyonocytic leukemia: a fortuitous association?
abstract: Langerhans cell histiocytosis (LCH) and malignancy occurring in the same individual is unusual and has generally been the subject of isolated case reports. LCH is a rare condition in adults. Its cause is uncertain but, with the recent demonstration of clonality and its association with malignant disease, there has been a renewal of interest. We report a singular case of Letterer-Siwe disease associated with a chronic myelomonocytic leukemia developing in an elderly woman. The simultaneous occurrence of both malignant disorders supports the hypothesis of a common genetic origin.
authors.affiliation: Dermatology Department, La Rabta Hospital, Jabbari, Bab Saadoun, Tunis, 1007 Tunisia.
authors.forename: H
authors.initials: H
authors.lastname: Hammami
authors.forename: I
authors.initials: I
authors.lastname: Zaraa
authors.forename: D
authors.initials: D
authors.lastname: El Euch
authors.forename: I
authors.initials: I
authors.lastname: Chelly
authors.forename: S
authors.initials: S
authors.lastname: Haouet
authors.forename: M
authors.initials: M
authors.lastname: Mokni
authors.forename: A
authors.initials: A
authors.lastname: Ben Osman
mesh_terms: D000368:Aged; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications* / Q000473:pathology*; D006801:Humans; D015477:Leukemia, Myelomonocytic, Chronic / Q000150:complications*