title: Remote near-IR light activation of a hyaluronic acid/poly(l-lysine) multilayered film and film-entrapped microcapsules.
abstract: Spontaneous embedding of gold nanoparticle (NP) aggregates or polyelectrolyte microcapsules modified with NPs in biocompatible hyaluronic acid/poly(l-lysine) films is reported. The NPs were adsorbed in the aggregated state to induce near-IR light absorption. The films functionalized with gold NPs become active in response to a "biologically friendly" near-IR laser at a power of about 20 mW. The activation is characterized by a localized temperature increase in the film, allowing conversion of light energy to heat into confined volumes. Microcapsules adsorbed onto the film can release its cargo under stimulation with near-IR light because of localized permeability changes in their walls. This work is aimed at layer-by-layer film-based biomedical coatings and active surfaces with light-sensitive features wherein metal NPs and microcapsules are used as active centers or carriers with remote control of functionalities.
authors.affiliation: Max-Planck Institute of Colloids and Interfaces, Research Campus Golm, Potsdam D-14424, Germany. dmitry.volodkin@mpikg.mpg.de
authors.forename: D V
authors.initials: DV
authors.lastname: Volodkin
authors.forename: M
authors.initials: M
authors.lastname: Delcea
authors.forename: H
authors.initials: H
authors.lastname: Möhwald
authors.forename: A G
authors.initials: AG
authors.lastname: Skirtach
mesh_terms: D000042:Absorption; D000327:Adsorption; D001672:Biocompatible Materials / Q000737:chemistry; D002214:Capsules; D006820:Hyaluronic Acid / Q000737:chemistry*; D007259:Infrared Rays; D008027:Light; D018625:Microscopy, Atomic Force / Q000379:methods; D018613:Microscopy, Confocal / Q000379:methods; D046529:Microscopy, Electron, Transmission / Q000379:methods; D036103:Nanotechnology / Q000379:methods; D010539:Permeability; D011107:Polylysine / Q000737:chemistry*; D013499:Surface Properties; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D002214:Capsules; D011107:Polylysine; D006820:Hyaluronic Acid