Exposing viruses: RNA patterns sensed by RIG-I-like receptors.
BACKGROUND
Virus infection triggers a multitude of innate immune pathways that limit viral replication, restrict viral spread and coordinate antigen-specific, adaptive immune responses. Type-I interferons (IFNs) play a crucial role in these events. Innate receptors expressed by the host cell recognize virus presence and signal for rapid IFN induction following infection.


METHODS
This review article discusses recent progress in our understanding of how cytoplasmic RIG-I-like receptors detect infection with RNA viruses.
Rehwinkel
Jan
J
Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK. jan.rehwinkel@cancer.org.uk
D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000276:immunology; D012328:RNA Viruses / Q000276:immunology*; D011971:Receptors, Immunologic; D051192:Receptors, Pattern Recognition / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology
D007370:Interferon Type I; D011971:Receptors, Immunologic; D051192:Receptors, Pattern Recognition; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases