title: B cell aplasia and hypogammaglobulinemia after carbamazepine treatment.
abstract: Although immunosuppressive effects of antiepileptic drug are well known, serious complications of antiepileptic drug are rare. We report a case of hypogammaglobulinemia associated with aplasia of B lymphocytes after carbamazepine treatment. Despite repeated intravenous immunoglobulin replacement therapy, this condition persisted for more than three months. The present case suggested that routine monitoring of the blood cell count and serum levels of immunoglobulin are important in patients treated with carbamazepine, and a lymphocyte subpopulation study is valuable in cases of hypogammaglobulinemia.
authors.affiliation: Department of Neurology, Graduate School of Medicine, Chiba University, Chiba. tatsuya-yamamoto@mbc.nifty.com
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Uchiyama
authors.forename: Hirokatsu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Himuro
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Kanai
authors.forename: Satoshi
authors.initials: S
authors.lastname: Kuwabara
mesh_terms: D000328:Adult; D000361:Agammaglobulinemia / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology*; D016175:B-Lymphocyte Subsets / Q000187:drug effects* / Q000473:pathology*; D002220:Carbamazepine / Q000009:adverse effects*; D006801:Humans; D008231:Lymphopenia / Q000139:chemically induced / Q000276:immunology* / Q000473:pathology*; D008297:Male
chemical_list: D002220:Carbamazepine