[Analysis of safety and effects on the oral whole cell/recombinant B subunit cholera vaccine in university students and workers].
OBJECTIVE
To evaluate the safety, immunogenicity and protective efficiency of the oral whole cell/recombinant B subunit cholera vaccine in Beijing Olympic volunteers and workers.


METHODS
Analyzing the incidence rate of adverse reaction and Protective Rate (PR) after taking the vaccine in Olympic volunteers in 6 universities in Beijing; comparing the anti-cholera toxin (CT) detected with ELISA prior and after taking the vaccine in Olympic workers.


RESULTS
The total rate of adverse reaction of Olympic volunteers was 0.38%; the main side effects were gastrointestinal symptoms, such as bellyache and diarrhea which were mild and temple; the acute diarrhea incidence rate of Olympic volunteers after taking the vaccine was significantly lower than those not taking it, the PR was 76.27%; the positive rate of anti-CT of Olympic workers after taking the vaccine was significantly higher than those before taking it, the levels of anti-CT titers declined after 6 months since they had taken the vaccine.


CONCLUSIONS
The results from above two observed population indicate that the oral rBS-WC cholera vaccine is efficient and safe.
Shi
Nian-min
NM
Center of Disease Control and Prevention, Chaoyang District, Beijing 100021, China. shinianmin@sina.com
Luo
Feng-ji
FJ
Li
Shu-ming
SM
Bai
Yun-hua
YH
Qu
Yan
Y
Song
Xin
X
D000906:Antibodies / Q000032:analysis*; D002771:Cholera / Q000517:prevention & control*; D002772:Cholera Toxin / Q000276:immunology; D022121:Cholera Vaccines / Q000009:adverse effects* / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D013334:Students; D014614:Vaccines, Synthetic / Q000009:adverse effects / Q000276:immunology; D055815:Young Adult
D000906:Antibodies; D022121:Cholera Vaccines; D014614:Vaccines, Synthetic; D002772:Cholera Toxin