title: Panton-Valentine leukocidin Staphylococcus aureus osteomyelitis of the adult tibia--a case report.
abstract: Panton-Valentine leukocidin toxin producing Staphylococcus aureus (PVLSA) is known to be responsible for recurrent soft tissue infections and more serious invasive infections including necrotising pneumonia, pyomyositis, and osteomyelitis. Most reported cases involving musculoskeletal infection in adults are associated with methicillin-resistant S. aureus (MRSA) PVL-producing strains. We present the case of an adult male with PVL toxin-producing methicillin-sensitive S. aureus (MSSA) osteomyelitis of the tibia which has not previously been described in adults and highlight issues of recognition, treatment, and surgical management of PVLSA osteomyelitis.
authors.affiliation: Derriford Hospital, Plymouth, UK. matthall50@yahoo.com
authors.forename: M J
authors.initials: MJ
authors.lastname: Hall
authors.forename: J A
authors.initials: JA
authors.lastname: Steer
authors.forename: J
authors.initials: J
authors.lastname: Keenan
mesh_terms: D001427:Bacterial Toxins / Q000096:biosynthesis*; D005098:Exotoxins / Q000096:biosynthesis*; D006801:Humans; D007956:Leukocidins / Q000096:biosynthesis*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000175:diagnosis* / Q000382:microbiology / Q000601:surgery; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000382:microbiology / Q000601:surgery; D013211:Staphylococcus aureus / Q000378:metabolism*; D013977:Tibia / Q000382:microbiology* / Q000601:surgery
chemical_list: D001427:Bacterial Toxins; D005098:Exotoxins; D007956:Leukocidins; C078284:Panton-Valentine leukocidin