A substrate-independent approach for bactericidal surfaces.
Existing methods for imparting antibacterial performance to solid surfaces tend to either be substrate-specific or rely upon leaching modes of action that cause ecological damage. An alternative approach is outlined comprising plasmachemical functionalization of solid surfaces with poly(4-vinyl pyridine) moieties and their subsequent activation (quaternization) with bromobutane to yield bactericidal activity. These bioactive surfaces can be applied to a host of different substrate materials and are easily regenerated by rinsing in water.
Schofield
W C E
WC
Department of Chemistry, Science Laboratories, Durham University, Durham DH1 3LE, England, United Kingdom.
Badyal
J P S
JP
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D015169:Colony Count, Microbial; D006842:Hydrocarbons, Brominated / Q000737:chemistry / Q000494:pharmacology*; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D056951:Photoelectron Spectroscopy; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D013499:Surface Properties / Q000187:drug effects
D000900:Anti-Bacterial Agents; D006842:Hydrocarbons, Brominated; D011725:Pyridines; C029351:4-vinylpyridine; C047757:butyl bromide