title: [Role of 125I seed implantation in treatment of unresectable pancreatic cancer].
abstract: OBJECTIVE
  To study the role of (125)I seed implantation in the treatment of unresectable pancreatic cancer.
  
  
  METHODS
  From April 2004 to march 2006, 66 untreated patients with locally advanced pancreatic cancer (LAPC) were randomized into two groups: Group A: (125)I seeds implantation (n = 31) and Group B: control (n = 34). The objective tumor response, clinical benefit response, toxicity, complications and survival of two groups were observed.
  
  
  RESULTS
  In Group A, the overall response rate (PR + NC) was 80.6%. Clinical benefit response rate was 54.8%. No toxicity was observed. Gastrointestinal hemorrhage and pancreatic fistula occurred in 1 patient respectively in Group A. The survival rates of 6 and 12 months were 56.0% vs 31.4% and 16.8% vs 2.9% respectively in two groups (P < 0.05). The median survival time of two groups was 8.0 months vs 4.0 months (P < 0.05).
  
  
  CONCLUSIONS
  (125)I seed implantation is a simple, safe and effective method in the treatment of locally advanced pancreatic cancer.
authors.affiliation: Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
authors.forename: Cheng-feng
authors.initials: CF
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Zhao
authors.forename: Ye-xiong
authors.initials: YX
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Shan
authors.forename: Dong-bing
authors.initials: DB
authors.lastname: Zhao
authors.forename: Yan-tao
authors.initials: YT
authors.lastname: Tian
authors.forename: Yue-min
authors.initials: YM
authors.lastname: Sun
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Bai
authors.forename: Xu
authors.initials: X
authors.lastname: Che
authors.forename: Hui
authors.initials: H
authors.lastname: Qu
authors.forename: Yi-bin
authors.initials: YB
authors.lastname: Xie
authors.forename: Rong
authors.initials: R
authors.lastname: Zheng
authors.forename: Chun-wu
authors.initials: CW
authors.lastname: Zhou
mesh_terms: D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D011859:Radiography; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D007457:Iodine Radioisotopes