title: Diffusion tensor imaging of the cortical plate and subplate in very-low-birth-weight infants.
abstract: BACKGROUND
  Many intervention studies in preterm infants aim to improve neurodevelopmental outcome, but short-term proxy outcome measurements are lacking. Cortical plate and subplate development could be such a marker.
  
  
  OBJECTIVE
  Our aim was to provide normal DTI reference values for the cortical plate and subplate of preterm infants.
  
  
  METHODS
  As part of an ongoing study we analysed diffusion tensor imaging (DTI) images of 19 preterm infants without evidence of injury on conventional MRI, with normal outcome (Bayley-II assessed at age 2), and scanned in the first 4 days of life. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values in the frontal and temporal subplate and cortical plate were measured in single and multiple voxel regions of interest (ROI) placed on predefined regions.
  
  
  RESULTS
  Using single-voxel ROIs, statistically significant inverse correlation was found between gestational age (GA) and FA of the frontal (r = -0.5938, P = 0.0058) and temporal (r = -0.4912, P = 0.0327) cortical plate. ADC values had a significant positive correlation with GA in the frontal (r = 0.5427, P = 0.0164) and temporal (r = 0.5540, P = 0.0138) subplate.
  
  
  CONCLUSIONS
  Diffusion tensor imaging allows in vivo exploration of the evolving cortical plate and subplate. We provide FA and ADC values of the subplate and cortical plate in very-low-birth-weight (VLBW) infants with normal developmental outcome that can be used as reference values.
authors.affiliation: Division of Neonatology, Department of Paediatrics, Erasmus MC-Sophia Children's Hospital, Rotterdam, The Netherlands. j.dudink@erasmusmc.nl
authors.forename: Jeroen
authors.initials: J
authors.lastname: Dudink
authors.forename: Jan
authors.initials: J
authors.lastname: Buijs
authors.forename: Paul
authors.initials: P
authors.lastname: Govaert
authors.forename: Arjen L
authors.initials: AL
authors.lastname: van Zwol
authors.forename: Nikk
authors.initials: N
authors.lastname: Conneman
authors.forename: Johannes B
authors.initials: JB
authors.lastname: van Goudoever
authors.forename: Maarten
authors.initials: M
authors.lastname: Lequin
mesh_terms: D002540:Cerebral Cortex / Q000002:abnormalities / Q000000981:diagnostic imaging*; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D006801:Humans; D007231:Infant, Newborn; D019102:Infant, Very Low Birth Weight; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging / Q000379:methods; D011859:Radiography