title: Adiposity in childhood is related to C-reactive protein and adiponectin in young adulthood: from the Bogalusa Heart Study.
abstract: To determine the association between cardiovascular (CV) risk factors in childhood and high-sensitivity C-reactive protein (hsCRP) and adiponectin in adulthood, 835 eligible white and African-American young adult subjects (age range 24-42 years, average 34 years, 43% men, 31% African Americans) who had CV risk-factor variable data from their childhood (20 years earlier, age range 5-18 years, average 14 years) were selected. Stepwise linear regression models revealed that mean logarithmic hsCRP level in adulthood was 0.02 greater with every increase of 1 mm in skinfold thickness in childhood, 0.25 greater for African Americans than whites, 0.36 greater for girls than boys, and 0.15 greater for every unit increase in BMI z score. Mean logarithmic adiponectin level in adulthood was 0.36 greater for girls than boys, 0.22 greater for whites than African Americans, and 0.01 less with every increase of 1 mm of childhood skinfold thickness. Seventy participants (8%) were overweight or obese in their childhood, and 64 of these (91%) remained obese in their young adulthood. In conclusion, childhood adiposity and African-American race were associated with higher hsCRP and lower adiponectin levels in their adulthood. Skinfold thickness and BMI z score in childhood were the main obesity determinants for higher hsCRP and lower adiponectin levels in young adulthood.
authors.affiliation: Tulane Center for Cardiovascular Health, New Orleans, Louisiana, USA.
authors.forename: Demet
authors.initials: D
authors.lastname: Toprak
authors.forename: Ahmet
authors.initials: A
authors.lastname: Toprak
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Ji Hua
authors.initials: JH
authors.lastname: Xu
authors.forename: Sathanur
authors.initials: S
authors.lastname: Srinivasan
authors.forename: Gerald S
authors.initials: GS
authors.lastname: Berenson
mesh_terms: D052242:Adiponectin / Q000032:analysis / Q000378:metabolism; D050154:Adiposity / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D001741:Black or African American; D000367:Age Factors; D002097:C-Reactive Protein / Q000032:analysis / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008145:Louisiana / Q000453:epidemiology; D008297:Male; D009765:Obesity / Q000097:blood* / Q000453:epidemiology / Q000208:ethnology / Q000378:metabolism; D044465:White People; D055815:Young Adult
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D002097:C-Reactive Protein