[The blocade of glutamate metabotropic 5-th tipe receptors prevents the locomotor behavior changes produced by intrastriatal picrotoxin microinjections in rats].
It was demonstrated in chronic experiments in Wistar rats that only the first of daily multiple microinjections of glutamate metabotropic 5-th type receptor antagonist MTEP into the rostral region of neostriatum impaired the avoidance conditioning in a shuttle box. Within the next two weeks, MTEP was ineffective but being injected into the neostriatum simultaneously with picrotoxin prevented the impairment of avoidance conditioning in a shuttle-box and decreased the hyperactivity (open-field locomotor hyperactivity and choreic hyperkinesis) produced by this GABA-A receptor antagonist. The results do not suggest the involvement of striatal glutamate metabotropic 5-th type receptors in avoidance conditioning control but demonstrate that glutamate metabotropic system is involved in behavioral disorders mediated by inhibition of GABA-A receptors. In principle, it might be possible to treat the human hyperkinetic basal ganglia dysfunction (Huntington's horea), athetosis and similar disorders with glutamate metabotropic receptor antagonists.
Iakimovskiĭ
A F
AF
Red'ka
Iu A
IuA
Iakubenko
A L
AL
D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects*; D004924:Escape Reaction / Q000187:drug effects; D018756:GABA Antagonists / Q000008:administration & dosage; D006801:Humans; D006816:Huntington Disease / Q000188:drug therapy; D006948:Hyperkinesis / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D008124:Locomotion / Q000187:drug effects; D008845:Microinjections; D017072:Neostriatum / Q000187:drug effects; D010852:Picrotoxin / Q000008:administration & dosage; D011725:Pyridines / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors*; D013844:Thiazoles / Q000008:administration & dosage*
D018756:GABA Antagonists; D010852:Picrotoxin; D011725:Pyridines; D064529:Receptor, Metabotropic Glutamate 5; D018094:Receptors, Metabotropic Glutamate; D013844:Thiazoles; C472365:3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine