title: Attenuated total reflection Fourier transform infrared spectroscopy for on-chip monitoring of solute concentrations.
abstract: We report a cost-efficient Attenuated Total Reflection Fourier Transform Infrared Spectroscopy (ATR-FTIR) method for monitoring concentrations of solutes in solutions flowing through microfluidic channels. The method allows rapid acquisition of spectra and enables chemical characterisation and concentration measurements that are independent of the flow rate of liquids. The method enables independent measurement of concentrations of solutes with distinct spectral features in mixed solutions. For the polymer solutes studied in the present work, the method has a sensitivity of at least 10 microM (0.01 wt%). We also propose the applicability of the method for the differentiation between dissolved and adsorbed amphiphilic species.
authors.affiliation: Department of Chemistry, University of Toronto, 80 Saint George Street, Toronto, Ontario, Canada M5S 3H6.
authors.forename: Jesse
authors.initials: J
authors.lastname: Greener
authors.forename: Bardia
authors.initials: B
authors.lastname: Abbasi
authors.forename: Eugenia
authors.initials: E
authors.lastname: Kumacheva
mesh_terms: D000327:Adsorption; D046210:Microfluidic Analytical Techniques; D055668:Photochemical Processes; D011108:Polymers / Q000032:analysis / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared / Q000191:economics / Q000295:instrumentation*; D013501:Surface-Active Agents / Q000737:chemistry; D013997:Time Factors; D014466:Ultraviolet Rays
chemical_list: D011108:Polymers; D013501:Surface-Active Agents