title: The effect of incorporating Fréchet dendrons into rotaxanes and molecular shuttles containing the 1,2-bis(pyridinium)ethane⊂[24]crown-8 templating motif.
abstract: Fréchet-type dendrons (G0-G3) were added as both axle stoppering units and cyclic wheel appendages in a series of [2]rotaxanes, [3]rotaxanes, and molecular shuttles that employ 1,2-bis(pyridinium)ethane axles and 24-membered crown ethers wheels. The addition of dendrimer wedges as stoppering units dramatically increased the solubility of simple [2]rotaxanes in nonpolar solvents. The X-ray structure of a G1-stoppered [2]rotaxane shows how the dendritic units affect the structure of the interlocked components. Increased solubility allows observation of how the interaction of dendritic units on separate components in interlocked molecules influences switching properties and molecular size. In a series of [2]rotaxane molecular shuttles incorporating two recognition sites, it was demonstrated that an increase in generation on either the stoppering unit or cyclic wheel could influence both the rate of shuttling and the site preference of the wheel on the axle.
authors.affiliation: Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, N9B 3P4 (Canada), Fax: (+1) 519-973-7098.
authors.forename: David A
authors.initials: DA
authors.lastname: Tramontozzi
authors.forename: Natalie D
authors.initials: ND
authors.lastname: Suhan
authors.forename: S Holger
authors.initials: SH
authors.lastname: Eichhorn
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Loeb