title: [Optimization of cataplasm matrix with face-centered design-response surface method].
abstract: OBJECTIVE
  To optimize the matrix formulation of cataplasm.
  
  
  METHODS
  Face-centered design was used in the experimental design, and response surface was produced in quadratic polynomial after data fitting in order to explore the impacts of Sodium Polyacrylate, Carbomer and the cross-linking agent on stickiness of cataplasm, optimize the prescription of the cataplasm matrix and perform the evaluation analysis.
  
  
  RESULTS
  The multiple correlation coefficient (R2) and adjusted R2 in the fitting method using quadratic polynomial were 0.970 and 0. 952 (F = 53.953, P = 0.0001), respectively, and the model was significant different. The ratio of optimum proportion of Sodium Polyacrylate, Carbomer and the cross-linking agent in the matrix of cataplasm was determined, which was proved efficaciously.
  
  
  CONCLUSIONS
  Face-centered design-response surface method is a simple method with good prediction result for the optimization of cataplasm matrix.
authors.affiliation: Institute of Chinese Materia Medical, China Academy of Chinese Medical Sciences, Beijing 100700, China. liushuzhi2004@sina.com
authors.forename: Shuzhi
authors.initials: S
authors.lastname: Liu
authors.forename: Junhong
authors.initials: J
authors.lastname: Li
authors.forename: Rixian
authors.initials: R
authors.lastname: Jin
authors.forename: Maobo
authors.initials: M
authors.lastname: Du
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D008962:Models, Theoretical
chemical_list: D004365:Drugs, Chinese Herbal