Early and sustained systemic and renal hemodynamic effects of intravenous radiocontrast.
OBJECTIVE
To measure the extended renal hemodynamic changes induced by intravenous radiocontrast.


METHODS
Cross-ewes were studied in a randomized cross-over study. Intravenous saline or radiocontrast were administered, and continuous measurement of cardiac output and renal blood flow (RBF) was performed with flow probes.


RESULTS
Radiocontrast induced early but transient increases in cardiac output with vasodilatation, followed by return to baseline values within 2 h. There was an initial decline in RBF (-5.2 +/- 4.5 vs. 2.1 +/- 5.3%; p < 0.0001) and decreased renal vascular conductance (-4.0 +/- 7.2 vs. 3.3 +/- 7.1%, p < 0.0001; vasoconstriction). This renal vasoconstriction resolved within 2 h and was followed by sustained (72 h) renal vasodilatation with higher RBF (270 +/- 13 vs. 236 +/- 11 ml/min; p < 0.0001).


CONCLUSIONS
Radiocontrast induces short renal vasoconstriction followed by sustained vasodilatation and increased RBF. Short-term studies are not representative of the overall sustained renal hemodynamic effects of radiocontrast.
Saotome
Takao
T
Howard Florey Institute, University of Melbourne, Parkville, Vic., Australia.
Langenberg
Christoph
C
Wan
Li
L
Ramchandra
Rohit
R
May
Clive N
CN
Bellomo
Rinaldo
R
Bailey
Michael
M
Bagshaw
Sean M
SM
D000818:Animals; D002302:Cardiac Output; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology*; D018592:Cross-Over Studies; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007472:Iohexol / Q000008:administration & dosage / Q000494:pharmacology; D007668:Kidney / Q000098:blood supply*; D012039:Regional Blood Flow; D012756:Sheep; D014664:Vasodilation
D003287:Contrast Media; D007472:Iohexol