Interplay between DNA replication and gene expression: a harmonious coexistence.
Multicellular organisms have evolved highly sophisticated machinery to that their genomes are accurately duplicated and that the various gene expression programs are established correctly. Recent large-scale studies have shed light on how these fundamental processes interact. Although the machinery mediating these processes share similar cis-regulatory elements, they are not strictly coregulated. Furthermore, studies of the replisome show that highly transcribed genes present a major obstacle to its operation. Further studies will be needed to identify key regulators of the spatio-temporal program of DNA replication, for the elucidation of the complex interplay between replication and transcription.
Maric
Chrystelle
C
Institut Jacques Monod, Centre National de la Recherche Scientifique, Université Paris 7, Paris, France.
Prioleau
Marie-Noëlle
MN
D000818:Animals; D004261:DNA Replication / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D018741:Replication Origin / Q000235:genetics; D013997:Time Factors; D014158:Transcription, Genetic