A case of rapid progression and vision loss in a patient with primary intraocular lymphoma.
OBJECTIVE
To describe an atypical case of primary intraocular lymphoma (PIOL) with rapid progression leading to vision loss and death.


METHODS
A 71-year-old woman with a history of PIOL presented with a sudden decline in vision. MRI, CSF cytology, and ocular examination 2 months prior were unremarkable.


RESULTS
Repeat MRI of the brain and orbits at this time revealed a 0.8 x 2.4-cm lesion of the left choroid plexus. LP revealed rare atypical B cells. The patient rapidly deteriorated and died a month later.


CONCLUSIONS
Recognition of the potential for rapid progression and mortality in patients with PIOL is essential.
Sangave
Amit
A
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-1857, USA.
Faia
Lisa J
LJ
Yeh
Steven
S
Chan
Chi-Chao
CC
Nussenblatt
Robert B
RB
Sen
H Nida
HN
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001766:Blindness / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D018450:Disease Progression; D005134:Eye Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D011344:Procarbazine; D014750:Vincristine; D008727:Methotrexate