title: Solution-phase racemization in the presence of an enantiopure solid phase.
abstract: Solution-phase racemization drives the evolution of single chirality in the solid phase by the "chiral amnesia" process first described by Viedma. The current investigations lay the basis for a better understanding of the mechanism of the solid-phase deracemization by uncoupling the chemical rate processes associated with the interconversion of enantiomers in the solution phase from the physical processes associated with solution-solid phase transfer via dissolution and reaccretion of molecules onto crystals. In addition, the enantiomer concentration profiles presented in this work, together with an analytical treatment of the racemization process in the presence of excess enantiopure solid, unequivocally reconfirm the validity of the Meyerhoffer double solubility rule for systems under solution racemization conditions.
authors.affiliation: Departamento Cristalografia-Mineralogia, Facultad Geologia, Universidad Complutense, 28040 Madrid, Spain. viedma@geo.ucm.es
authors.forename: Cristobal
authors.initials: C
authors.lastname: Viedma
authors.forename: Bastiaan J V
authors.initials: BJ
authors.lastname: Verkuijl
authors.forename: José E
authors.initials: JE
authors.lastname: Ortiz
authors.forename: Trinidad
authors.initials: T
authors.lastname: de Torres
authors.forename: Richard M
authors.initials: RM
authors.lastname: Kellogg
authors.forename: Donna G
authors.initials: DG
authors.lastname: Blackmond
mesh_terms: D000577:Amides / Q000737:chemistry*; D001224:Aspartic Acid / Q000737:chemistry*; D001593:Benzyl Compounds / Q000737:chemistry*; D003461:Crystallography; D005998:Glycine / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D012995:Solubility; D012996:Solutions / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D001593:Benzyl Compounds; C531368:N-(2-methylbenzylidene)-phenylglycine amide; D012996:Solutions; D001224:Aspartic Acid; D005998:Glycine