title: Internet-delivered exposure and mindfulness based therapy for irritable bowel syndrome--a randomized controlled trial.
abstract: The aim of this study was to investigate if cognitive behavior therapy (CBT) based on exposure and mindfulness exercises delivered via the Internet would be effective in treating participants with irritable bowel syndrome (IBS). Participants were recruited through self-referral. Eighty-six participants were included in the study and randomized to treatment or control condition (an online discussion forum). One participant was excluded after randomization. The main outcome measure was IBS-symptom severity and secondary measures included IBS-related quality of life, GI-specific anxiety, depression and general functioning. Participants were assessed at pre-treatment, post-treatment and 3 month follow-up (treatment condition only). Four participants (5% of total sample) in the treatment condition did not participate in post-treatment assessment. Participants in the treatment condition reported a 42% decrease and participants in the control group reported a 12% increase in primary IBS-symptoms. Compared to the control condition, participants in the treatment group improved on all secondary outcome measures with a large between group effect size on quality of life (Cohen's d = 1.21). We conclude that CBT-based on exposure and mindfulness delivered via the Internet can be effective in treating IBS-patients, alleviating the total burden of symptoms and increasing quality of life.
authors.affiliation: Center for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, University Hospital Huddinge,Stockholm, Sweden. brjann.ljotsson@ki.se
authors.forename: Brjánn
authors.initials: B
authors.lastname: Ljótsson
authors.forename: Lisa
authors.initials: L
authors.lastname: Falk
authors.forename: Amanda Wibron
authors.initials: AW
authors.lastname: Vesterlund
authors.forename: Erik
authors.initials: E
authors.lastname: Hedman
authors.forename: Perjohan
authors.initials: P
authors.lastname: Lindfors
authors.forename: Christian
authors.initials: C
authors.lastname: Rück
authors.forename: Timo
authors.initials: T
authors.lastname: Hursti
authors.forename: Sergej
authors.initials: S
authors.lastname: Andréewitch
authors.forename: Liselotte
authors.initials: L
authors.lastname: Jansson
authors.forename: Nils
authors.initials: N
authors.lastname: Lindefors
authors.forename: Gerhard
authors.initials: G
authors.lastname: Andersson
mesh_terms: D000328:Adult; D001364:Awareness; D015928:Cognitive Behavioral Therapy / Q000295:instrumentation / Q000379:methods*; D003695:Delivery of Health Care / Q000379:methods; D003887:Desensitization, Psychologic / Q000379:methods*; D005260:Female; D006801:Humans; D020407:Internet; D043183:Irritable Bowel Syndrome / Q000523:psychology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D017216:Telemedicine / Q000295:instrumentation / Q000379:methods; D013813:Therapy, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult