title: Electropolymerized tricopolymer based on N-pyrrole derivatives as a primer coating for improving the performance of a drug-eluting stent.
abstract: The coating of medical implants by polymeric films aims at increasing their biocompatibility as well as providing a durable matrix for the controlled release of a drug. In many cases, the coating is divided into a primer layer, which bridges between the medical implant and the drug-eluting matrix. The primer coating must be very carefully designed in order to provide optimal interactions with the surface of the medical implant and the outer layer. Here we present a simple and versatile approach for designing the primer layer based on electropolymerization of a carefully chosen blend of three different pyrrole derivatives: N-methylpyrrole (N-me), N-(2-carboxyethyl)pyrrole (PPA), and the butyl ester of N-(2-carboxyethyl)pyrrole (BuOPy). The composition and physical properties of the primer layer were studied in detail by atomic force microscopy (AFM) and a nano scratch tester. The latter provides the in-depth analysis of the adhesion and viscoelasticity of the coating. AFM phase imaging reveals a uniform distribution of the three monomers forming rough morphology. This primer layer significantly improved the morphology, stability, and paclitaxel release profile of a paclitaxel-eluting matrix based on methyl and lauryl methacrylates.
authors.affiliation: Department of Inorganic and Analytical Chemistry, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
authors.forename: Regina
authors.initials: R
authors.lastname: Okner
authors.forename: Yulia
authors.initials: Y
authors.lastname: Shaulov
authors.forename: Noam
authors.initials: N
authors.lastname: Tal
authors.forename: Gregory
authors.initials: G
authors.lastname: Favaro
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Domb
authors.forename: Daniel
authors.initials: D
authors.lastname: Mandler
mesh_terms: D000042:Absorption; D001807:Blood Vessel Prosthesis; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D054855:Drug-Eluting Stents; D004563:Electrochemistry / Q000379:methods; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006244:Hardness; D008422:Materials Testing; D017239:Paclitaxel / Q000008:administration & dosage* / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D011108:Polymers; D011758:Pyrroles; D017239:Paclitaxel