Preparation of photocontrollable, nontoxicity complex of phenylazophenylalanine modified CdS quantum dots with cyclodextrin.
A novel complex of beta-cyclodextrin with phenylazophenylalanine (PAP)-conjugated CdS quantum dot (Fazo-CdS QD) was fabricated for a photocontrollable toxicity study of CdS. Photocontrolling release of Fazo-CdS QDs from the complex was confirmed under UV irradiation by the steady state photoluminescence (PL) spectroscopy. The cytotoxicity of the surface modified CdS QDs was evaluated in vivo. The results suggest that the Fazo-CdS QDs conjugated with beta-CD could be almost nontoxicity, which may have great potential applications in biological labeling and imaging.
Li
Yingying
Y
College of Materials Science and Technology, Nanjing University of Aeronautics and Astronautics, Naniing 210016, Jiangsu, China.
He
Zhipeng
Z
Zhang
Peigen
P
Gao
Junshan
J
Cheng
Chuanwei
C
Zhang
Haiqian
H
D000818:Animals; D001391:Azo Compounds / Q000737:chemistry* / Q000633:toxicity; D019187:Cadmium Compounds / Q000737:chemistry* / Q000633:toxicity; D005260:Female; D008099:Liver / Q000187:drug effects; D008163:Luminescent Measurements; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008819:Mice, Nude; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity; D045663:Quantum Dots; D018036:Selenium Compounds / Q000737:chemistry* / Q000633:toxicity; D047392:beta-Cyclodextrins / Q000737:chemistry* / Q000633:toxicity
C087328:4-phenylazophenylalanine; D001391:Azo Compounds; D019187:Cadmium Compounds; D008823:Micelles; D018036:Selenium Compounds; D047392:beta-Cyclodextrins; D010649:Phenylalanine; C058667:cadmium selenide