Cilia self-organize in response to planar cell polarity and flow.
Cilia drive fluid flow in development and physiology, but this requires that all cilia in a tissue orient the same way. Earlier studies indicated that both planar cell polarity (PCP) signalling and cilia-generated fluid flows could influence ciliary orientation. We now learn how asymmetric localization of PCP proteins influences the position and orientation of cilia to control the direction of flow.
Marshall
Wallace F
WF
Department of Biochemistry & Biophysics, UCSF, San Francisco, CA 94158, USA. wallace.marshall@ucsf.edu
D000818:Animals; D016764:Cell Polarity; D002555:Cerebrospinal Fluid / Q000378:metabolism; D002923:Cilia / Q000378:metabolism; D004805:Ependyma / Q000166:cytology* / Q000196:embryology / Q000378:metabolism; D025461:Feedback, Physiological; D006801:Humans; D040542:Mechanotransduction, Cellular; D009024:Morphogenesis; D009038:Motion; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D013314:Stress, Mechanical
C431577:Ltap protein, mouse; D009419:Nerve Tissue Proteins; D011993:Recombinant Fusion Proteins