title: Effects of alpha-glucosylhesperidin on the peripheral body temperature and autonomic nervous system.
abstract: We studied the effects of alpha-glucosylhesperidin (G-Hsp) on the peripheral body temperature and autonomic nervous system in humans. We first conducted a survey of 97 female university students about excessive sensitivity to the cold; 74% of them replied that they were susceptible or somewhat susceptible to the cold. We subsequently conducted a three-step experiment. In the first experiment, G-Hsp (500 mg) was proven to prevent a decrease in the peripheral body temperature under an ambient temperature of 24 degrees C. In the second experiment, a warm beverage containing G-Hsp promoted blood circulation and kept the finger temperature higher for a longer time. We finally used a heart-rate variability analysis to study whether G-Hsp changed the autonomic nervous activity. The high-frequency (HF) component tended to be higher, while the ratio of the low-frequency (LF)/HF components tended to be lower after the G-Hsp administration. These results suggest that the mechanism for temperature control by G-Hsp might involve an effect on the autonomic nervous system.
authors.affiliation: Institute of Health Sciences, Ezaki Glico Co., Ltd., Nishiyodogawa, Osaka, Japan. takumi-hiroko@glico.co.jp
authors.forename: Hiroko
authors.initials: H
authors.lastname: Takumi
authors.forename: Noboru
authors.initials: N
authors.lastname: Fujishima
authors.forename: Koso
authors.initials: K
authors.lastname: Shiraishi
authors.forename: Yuka
authors.initials: Y
authors.lastname: Mori
authors.forename: Ai
authors.initials: A
authors.lastname: Ariyama
authors.forename: Takashi
authors.initials: T
authors.lastname: Kometani
authors.forename: Shinichi
authors.initials: S
authors.lastname: Hashimoto
authors.forename: Tomonori
authors.initials: T
authors.lastname: Nadamoto
mesh_terms: D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology*; D003080:Cold Temperature; D004562:Electrocardiography; D005260:Female; D006801:Humans; D055815:Young Adult