title: Effect of regional fat loss assessed by DXA on insulin resistance and dyslipidaemia in obese women.
abstract: OBJECTIVE
  To investigate the impact of reduction in total fat mass (FM) and regional FMs on indices of insulin resistance and dyslipidaemia in obese women (BMI > 30 kg/m(2)) after a 1-year weight loss (WL) program; and, secondly, to investigate the potential predictive effect of baseline insulin resistance on reduction in total and regional FMs.
  
  
  METHODS
  In 35 women with > 4 kg weight loss, body composition by DXA (dual X-ray absorptiometry), fasting insulin, C-Peptide, insulin resistance (HOMA-IR), insulin sensitivity (QUICKI), metabolic clearance rate (MCRestOGTT) and serum lipids were assessed.
  
  
  RESULTS
  Mean WL was 9.6%; trunk and leg FM were reduced proportionally (14.9-14.7%). Improvement in HOMA-IR was 34.7%, insulin 30.7%, QUICKI 8.6% and MCRest OGTT 74%. The reduction in total, trunk and leg FM were similarly correlated with improvement in indices of insulin resistance (p < 0.001-0.05) and also with initial HOMA-IR (p = 0.000-0.02). In linear regressions improvement in HOMA-IR was similarly related with these FMs (p = 0.008), and initial HOMA predicted loss of trunk FM (p = 0.01). In multivariate analysis improvement in HOMA-IR was explained by loss of total FM (R(2) = 0.20, p = 0.004); improvement of QUICKI by loss of leg FM (R(2) = 0.33, p < 0.001).
  
  
  CONCLUSIONS
  Loss of leg FM and trunk FM had similar importance for the improvement in insulin resistance. Baseline HOMA-IR predicted the potential for reduction in trunk FM.
authors.affiliation: Spesialistsenteret Pilestredet Park, Oslo, Norway. g.aasen@usa.net
authors.forename: Gunnar
authors.initials: G
authors.lastname: Aasen
authors.forename: Hans
authors.initials: H
authors.lastname: Fagertun
authors.forename: Johan
authors.initials: J
authors.lastname: Halse
mesh_terms: D015502:Absorptiometry, Photon; D050154:Adiposity; D000328:Adult; D000368:Aged; D050171:Dyslipidemias / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000000981:diagnostic imaging* / Q000453:epidemiology; D015431:Weight Loss