Depolarization induced suppression of excitation and the emergence of ultraslow rhythms in neural networks.
Ultraslow fluctuations (0.01-0.1 Hz) are a feature of intrinsic brain activity of as yet unclear origin. We propose a candidate mechanism based on retrograde endocannabinoid signaling in a synaptically coupled network of excitatory neurons. This is known to cause depolarization-induced suppression of excitation (DISE), which we model phenomenologically. We construct emergent network oscillations in a globally coupled network and show that for strong synaptic coupling DISE can lead to a synchronized population burst at the frequencies of resting brain rhythms.
Hlinka
J
J
Division of Academic Radiology, University of Nottingham, Nottingham, NG7 2UH, United Kingdom.
Coombes
S
S
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology