title: A new alternative mechanism in glioblastoma vascularization: tubular vasculogenic mimicry.
abstract: Glioblastoma is one of the most angiogenic human tumours and endothelial proliferation is a hallmark of the disease. A better understanding of glioblastoma vasculature is needed to optimize anti-angiogenic therapy that has shown a high but transient efficacy. We analysed human glioblastoma tissues and found non-endothelial cell-lined blood vessels that were formed by tumour cells (vasculogenic mimicry of the tubular type). We hypothesized that CD133+ glioblastoma cells presenting stem-cell properties may express pro-vascular molecules allowing them to form blood vessels de novo. We demonstrated in vitro that glioblastoma stem-like cells were capable of vasculogenesis and endothelium-associated genes expression. Moreover, a fraction of these glioblastoma stem-like cells could transdifferentiate into vascular smooth muscle-like cells. We describe here a new mechanism of alternative glioblastoma vascularization and open a new perspective for the antivascular treatment strategy.
authors.affiliation: UMR975, Hôpital de la Salpêtrière, Université Pierre et Marie Curie, Paris, France. soufiane.elhallani@yahoo.ca
authors.forename: Soufiane
authors.initials: S
authors.lastname: El Hallani
authors.forename: Blandine
authors.initials: B
authors.lastname: Boisselier
authors.forename: Florent
authors.initials: F
authors.lastname: Peglion
authors.forename: Audrey
authors.initials: A
authors.lastname: Rousseau
authors.forename: Carole
authors.initials: C
authors.lastname: Colin
authors.forename: Ahmed
authors.initials: A
authors.lastname: Idbaih
authors.forename: Yannick
authors.initials: Y
authors.lastname: Marie
authors.forename: Karima
authors.initials: K
authors.lastname: Mokhtari
authors.forename: Jean-Léon
authors.initials: JL
authors.lastname: Thomas
authors.forename: Anne
authors.initials: A
authors.lastname: Eichmann
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Delattre
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Maniotis
authors.forename: Marc
authors.initials: M
authors.lastname: Sanson
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D001808:Blood Vessels / Q000166:cytology / Q000254:growth & development*; D002461:Cell Line, Transformed; D002478:Cells, Cultured; D042783:Endothelial Cells / Q000473:pathology / Q000502:physiology*; D005260:Female; D005909:Glioblastoma / Q000098:blood supply* / Q000235:genetics / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D018716:Molecular Mimicry / Q000502:physiology*; D014411:Neoplastic Stem Cells / Q000473:pathology / Q000502:physiology; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000503:physiopathology* / Q000628:therapy; D051381:Rats; D014407:Tumor Cells, Cultured