D225G mutation in the hemagglutinin protein found in 3 severe cases of 2009 pandemic influenza A (H1N1) in Spain.
From 27 April to 16 December 2009, we analyzed the hemagglutinin gene sequence of 2009 pandemic influenza A (H1N1) virus in 189 respiratory specimens. We only found the D225G mutation in 3 severe cases. However, it was not found in samples from other cases with or without clinical criteria of severity. The biologic significance of this mutation remains still unclear.
Antón
Andrés
A
Microbiology Laboratory, Hospital Clínic, 08036 Barcelona, Spain. aanton76@gmail.com
Marcos
María Angeles
MA
Martínez
Miguel Julián
MJ
Ramón
Susana
S
Martínez
Anna
A
Cardeñosa
Neus
N
Godoy
Pere
P
Torner
Nuria
N
De Molina
Patricia
P
Isanta
Ricard
R
Jiménez de Anta
María Teresa
MT
Pumarola
Tomàs
T
D006389:Hemagglutinins, Viral / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics* / Q000302:isolation & purification; D007251:Influenza, Human / Q000821:virology*; D020125:Mutation, Missense; D017354:Point Mutation; D017422:Sequence Analysis, DNA; D013030:Spain
D006389:Hemagglutinins, Viral; C458881:hemagglutinin fusogenic peptide, influenza virus