title: Antiplasmodial benzophenone derivatives from the root barks of Symphonia globulifera (Clusiaceae).
abstract: In an effort to find antimalarial drugs, a systematic in vitro evaluation on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) was undertaken on sixty plant extracts collected in French Guiana. The ethyl acetate extract obtained from the root barks of Symphonia globulifera exhibited a strong antiplasmodial activity (97% at 10 microg/ml). The phytochemical investigation of this extract led to the isolation of nine polycyclic polyprenylated acylphloroglucinol (PPAPs) compounds and two oxidized derivatives. All compounds showed antiplasmodial activity with IC(50)s ranged from 2.1 to 10.1 microM. A LC/ESI-MS(n) study performed on polyprenylated benzophenones previously isolated from Moronobea coccinea provided a reliable method for their detection in the extract and structural elucidation.
authors.affiliation: Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, Gif-sur-Yvette, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Marti
authors.forename: Véronique
authors.initials: V
authors.lastname: Eparvier
authors.forename: Christian
authors.initials: C
authors.lastname: Moretti
authors.forename: Soizic
authors.initials: S
authors.lastname: Prado
authors.forename: Philippe
authors.initials: P
authors.lastname: Grellier
authors.forename: Nathalie
authors.initials: N
authors.lastname: Hue
authors.forename: Odile
authors.initials: O
authors.lastname: Thoison
authors.forename: Bernard
authors.initials: B
authors.lastname: Delpech
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001577:Benzophenones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D028084:Clusiaceae / Q000737:chemistry*; D004351:Drug Resistance / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D005616:French Guiana; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D021261:Parasitic Sensitivity Tests; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D001577:Benzophenones; D002738:Chloroquine