[Morphological manifestations of neonatal bronchopulmonary dysplasia and cell renewal in the lung in this condition].
The lungs of 184 dead neonates and babies who were from birth on artificial ventilation with rough parameters and hyperoxygenation were found to have peculiar pathohistological changes that were used to work out an illustrated algorithm for the morphological diagnosis of neonatal bronchopulmonary dysplasia (NBPD). An immunohistochemical study was used to identify the cell renewal markers Ki67, Bcl2, P53, and CPP32. In NBPD, there was an extremely high expression of all the markers in the cells of the bronchial, alveolar epithelium and lung interstitium as compared with the control group. It is concluded that cell renewal is accelerated in the lung in NBPD and the disease progresses until death occurs in infants.
Samokhin
P A
PA
Tsetkova
Iu V
IuV
D015415:Biomarkers / Q000378:metabolism; D001980:Bronchi / Q000378:metabolism / Q000473:pathology; D001997:Bronchopulmonary Dysplasia / Q000378:metabolism / Q000473:pathology; D053148:Caspase 3 / Q000096:biosynthesis*; D049109:Cell Proliferation; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008297:Male; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D011650:Pulmonary Alveoli / Q000378:metabolism / Q000473:pathology; D020545:Respiratory Mucosa / Q000378:metabolism / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis
D015415:Biomarkers; D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; C505407:CASP3 protein, human; D053148:Caspase 3