title: [Preliminary study to investigate dynamic extract process of Huanglian Jiedu Tang and the mechanism of subsidence produce].
abstract: OBJECTIVE
  To study the phenomenon of subsidence emergence in the process of Huanglian Jiedu Tang decoction extraction, and the mechanism of subsidence emergence.
  
  
  METHODS
  UV was applied to determine the concentration of total alkaloids and total flavones; Simultaneous determination of berberine, jatrorrhizine, palmatine, baicalin and geniposide were carried out by HPLC; The solid holdup and precipitation rate were calculated by the formula. The relativity among these parameters was analyzed by the SPSS software program.
  
  
  RESULTS
  The contains of berberine, jatrorrhizine, palmatine in total alkaloids showed a good correlation with total alkaloids. The correlation between baicalin and total flavones was lower than that between geniposide and total flavones. Compared to precipitation rate, solided hold up shows a larger relevance with index component
  
  
  CONCLUSIONS
  With the change of time, the total alkaloids represented by berberine alkaloids and baicalin at a certain concentration can be regarded as the equilibrium point, or one generated by the critical point of precipitation, the reaction can generate "sediments"; because "precipitation objects" generated, reducing the concentration of the above-mentioned components, destroy the" balance". The relevant components of herbal medicine increased dissolution rate, at the same time might partly dissolved sediment, reaching a new equilibrium state.
authors.affiliation: Separation Engineering of Chinese Traditional Medicine Compound, Nanjing University of Chinese Medicine, Nanjing 210029, China. linmeip@yahoo.com.cn
authors.forename: Linmei
authors.initials: L
authors.lastname: Pan
authors.forename: Jia
authors.initials: J
authors.lastname: Fu
authors.forename: Huaxu
authors.initials: H
authors.lastname: Zhu
authors.forename: Liwei
authors.initials: L
authors.lastname: Guo
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification*; D001599:Berberine / Q000031:analogs & derivatives / Q000302:isolation & purification; D001600:Berberine Alkaloids / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D047309:Flavones / Q000302:isolation & purification*; D005419:Flavonoids / Q000302:isolation & purification; D005590:Fractional Precipitation; D039823:Iridoids / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; D047309:Flavones; D005419:Flavonoids; D039823:Iridoids; C494417:huanglian; C055785:jatrorrhizine; D001599:Berberine; C007835:geniposide; C038044:baicalin; C005413:palmatine