title: Action-potential-encoded second-harmonic generation as an ultrafast local probe for nonintrusive membrane diagnostics.
abstract: The Hodgkin-Huxley treatment of the dynamics of a nerve impulse on a cell membrane is combined with a phenomenological description of molecular hyperpolarizabilities to develop a closed-form model of an action-potential-sensitive second-harmonic response of membrane-bound chromophores. This model is employed to understand the key properties of the map between the action potential and modulation of the second harmonic from a cell membrane stained with hyperpolarizable chromophore molecules.
authors.affiliation: Department of Mechanical and Aerospace Engineering, Princeton University, Princeton, New Jersey 08544-5263, USA.
authors.forename: M N
authors.initials: MN
authors.lastname: Shneider
authors.forename: A A
authors.initials: AA
authors.lastname: Voronin
authors.forename: A M
authors.initials: AM
authors.lastname: Zheltikov
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D002462:Cell Membrane / Q000502:physiology*; D003198:Computer Simulation; D008564:Membrane Potentials / Q000502:physiology*; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*