title: Interleukin 10 polymorphisms differentially influence the risk of gastric cancer in East Asians and Caucasians.
abstract: BACKGROUND
  Although a number of association studies of gastric cancer (GC) risk have been conducted worldwide, their results have been inconsistent among different populations. The association between GC incidence and Helicobacter pylori (H. pylori) infection is somewhat of an enigma that has yet to be clearly explained. Geographically-restricted positive selection due to unique environmental pressures often result in large allele frequency differences between populations. Thus, population differences need to be investigated when attempting to identify genes that contribute to phenotypes that differ greatly between populations.
  
  
  METHODS
  We analyzed population differences in 18 polymorphisms of 12 GC-associated or immune response-related genes from 3 ethnic groups comprising 50 Koreans, 46 Indians, and 60 Caucasians; these groups differed in H. pylori seropositivity and susceptibility to GC.
  
  
  RESULTS
  An interleukin 10 (IL10) polymorphism demonstrated a significantly different genotype distribution (F(ST)=0.306, P=0.014), indicating a large difference between the Korean and Caucasian populations. The odds ratio of IL10 polymorphism allele between the populations was 38.32 (95% confidence interval, 11.49-127.83).
  
  
  CONCLUSIONS
  This finding, taken together with previous evidence, provides a possible explanation for previous discrepant association results and supports the idea that IL10 gene polymorphisms can differentially affect GC development among populations.
authors.affiliation: Samsung Biomedical Research Institute, Samsung Medical Center, 50 Ilwon-Dong, Gangnam-Gu, Seoul 135-710, Republic of Korea.
authors.forename: Hong-Hee
authors.initials: HH
authors.lastname: Won
authors.forename: Jong-Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Min-Ji
authors.initials: MJ
authors.lastname: Kim
authors.forename: Seonwoo
authors.initials: S
authors.lastname: Kim
authors.forename: Jun-Hee
authors.initials: JH
authors.lastname: Park
authors.forename: Kyung-A
authors.initials: KA
authors.lastname: Lee
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D007194:India / Q000208:ethnology; D016753:Interleukin-10 / Q000235:genetics*; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D056910:Republic of Korea / Q000208:ethnology; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics*; D044465:White People / Q000235:genetics*
chemical_list: D016753:Interleukin-10