title: Designing vaccines against cattle brucellosis.
abstract: The article presents the results from a study of two new vaccines against cattle brucellosis from Brucella abortus cultures. One of these is a live dry vaccine prepared from a weakly agglutinogenic strain in the SR form and the second, an inactivated adjuvant vaccine from an non-agglutinogenic strain in the R form. The immunogenic properties of the vaccines were studied in three tests on heifers with infection by a virulent B. abortus culture. The vaccines passed the farm-scale testing and were accepted in veterinary practice.
authors.affiliation: FSI(1) National Center on Quality and Standardization of Veterinary Medications and Feed (VGNKI), 5 Zvenigorodskoe shosse, D-22 Moscow, Russia. Vgnki-vet@mtu-net.ru
authors.forename: Konstantin V
authors.initials: KV
authors.lastname: Shumilov
authors.forename: Oleg
authors.initials: O
authors.lastname: Sklyarov
authors.forename: Arkadii
authors.initials: A
authors.lastname: Klimanov
mesh_terms: D000034:Abortion, Veterinary / Q000517:prevention & control*; D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D002004:Brucella Vaccine / Q000276:immunology*; D002003:Brucella abortus / Q000276:immunology*; D002007:Brucellosis, Bovine / Q000276:immunology / Q000517:prevention & control*; D002417:Cattle; D005260:Female; D011247:Pregnancy; D015164:Vaccines, Inactivated / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D002004:Brucella Vaccine; D015164:Vaccines, Inactivated