New automated hepatitis C virus (HCV) core antigen assay as an alternative to real-time PCR for HCV RNA quantification.
An automated hepatitis C virus (HCV) antigen (Ag) assay was evaluated with clinical samples. Determination of HCV Ag and RNA levels in 282 subjects using Abbott HCV Ag and Roche Cobas TaqMan assays revealed that these two tests were highly correlated (r = 0.9464). Thus, the HCV Ag assay could be an alternative test to quantitative reverse transcription-PCR.
Park
Yongjung
Y
Department of Laboratory Medicine, Yonsei University College of Medicine, 250 Seongsan-no, Seodaemun-gu, Seoul 120-752, South Korea.
Lee
Jong-Han
JH
Kim
Beom Seok
BS
Kim
Do Young
DY
Han
Kwang-Hyub
KH
Kim
Hyon-Suk
HS
D000956:Antigens, Viral / Q000097:blood*; D001331:Automation / Q000379:methods*; D016174:Hepacivirus / Q000302:isolation & purification*; D006801:Humans; D012367:RNA, Viral / Q000097:blood; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013223:Statistics as Topic; D014758:Viral Core Proteins / Q000097:blood*; D019562:Viral Load / Q000379:methods*
D000956:Antigens, Viral; D012367:RNA, Viral; D014758:Viral Core Proteins; C069130:nucleocapsid protein, Hepatitis C virus