Diacylglycerol-mediated insulin resistance.
Understanding the molecular mechanisms of insulin resistance remains a major medical challenge of the twenty-first century. Over the last half-century, many hypotheses have been proposed to explain insulin resistance, and, most recently, inflammation associated with alterations in adipocytokines has become the prevailing hypothesis. Here we discuss diacylglycerol-mediated insulin resistance as an alternative and unifying hypothesis to explain the most common forms of insulin resistance associated with obesity and type 2 diabetes mellitus, as well as lipodystrophy and aging.
Erion
Derek M
DM
Department of Internal Medicine, Howard Hughes Medical Institute, USA.
Shulman
Gerald I
GI
D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D004075:Diglycerides / Q000502:physiology*; D007249:Inflammation / Q000378:metabolism / Q000503:physiopathology; D007333:Insulin Resistance / Q000502:physiology*; D008055:Lipids / Q000502:physiology; D008099:Liver / Q000378:metabolism / Q000502:physiology; D018482:Muscle, Skeletal / Q000378:metabolism / Q000502:physiology; D009765:Obesity / Q000503:physiopathology
D004075:Diglycerides; D008055:Lipids