Cancer sequencing gets a little more personal.
In this Perspective, we discuss a paper in this issue of Science Translational Medicine, in which Leary and colleagues present a new method based on massive, parallel, and near-complete sequencing of individual tumor genomes. Their findings support the notion that cancer genomes house a spectrum of genetic alterations, many of which are unique to the individual tumor. More validation and a reduction in cost are required for this approach to become common in clinics.
Prokunina-Olsson
Ludmila
L
Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892-4605, USA.
Chanock
Stephen J
SJ
D016678:Genome; D023281:Genomics / Q000379:methods; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods