Knocking down gene expression with dendritic vectors.
The aim of this review is to provide the reader with an overview on the potential of dendritic polymers in the antisense delivery technology. Special emphasis has been placed on the different types of dendritic structures that have been reported and the modifications performed to increase their efficacy and safety. Therefore the advances made in their chemistry and how it has been adapted to meet the specific requirements of the antisense delivery technology are reviewed and discussed.
Raviña
M
M
Department of Pharmacy and Pharmaceutical Technology, University of Santiago de Compostela, Santiago de Compostela, Spain.
Paolicelli
P
P
Seijo
B
B
Sanchez
A
A
D000818:Animals; D016375:Antisense Elements (Genetics); D021881:DNA, Catalytic / Q000378:metabolism / Q000627:therapeutic use; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry; D005786:Gene Expression Regulation; D055785:Gene Knockdown Techniques / Q000379:methods* / Q000639:trends; D015316:Genetic Therapy; D006801:Humans; D016376:Oligonucleotides, Antisense; D034622:RNA Interference; D016337:RNA, Catalytic / Q000378:metabolism; D034741:RNA, Small Interfering
D016375:Antisense Elements (Genetics); D021881:DNA, Catalytic; D050091:Dendrimers; D016376:Oligonucleotides, Antisense; C104700:PAMAM Starburst; D016337:RNA, Catalytic; D034741:RNA, Small Interfering