title: Expression and significance of FXYD-3 protein in gastric adenocarcinoma.
abstract: OBJECTIVE
  FXYD-3, also known as Mat-8, is a member of the FXYD protein family. It was reported that this protein can associate with and modify the transport properties of Na, K-ATPase, and may play an important role in a variety of physiological and pathological states. This protein is up-regulated in certain types of cancers (such as breast, prostate and pancreatic cancer), but down-regulated in other types of cancers (such as colon and kidney cancer). No study has been performed in gastric cancer; therefore, the aim of this project was to investigate FXYD-3 expression and its clinicopathological significance in gastric adenocarcinoma.
  
  
  METHODS
  FXYD-3 protein was examined by immunohistochemistry in normal gastric mucous (n= 29) and gastric adenocarcinoma (n=51), obtained from surgical resection of gastric cancer patients.
  
  
  RESULTS
  FXYD-3 protein was present in the cytoplasm of normal gastric epithelial cells or gastric cancer cells. The rate of FXYD-3 strong expression was significantly higher in cancer (51% of 51) than in normal mucosa (10% of 29, X<formula>;{2}</formula>=13.210, p < 0.0001). FXYD-3 expressed strongly in ulcerative/infiltrating types of cancers compared to polypoid/fungating ones (X<formula>;{2}</formula>=5.765, p=0.016). However, FXYD-3 expression was not correlated with patient's gender, age, tumor size, lymph node status and histological grade (p > 0.05). Conclosion: Up-regulated expression of FXYD-3 protein may be involved in tumourgenesis and invasion of gastric adenocarcinoma.
authors.affiliation: Center of Scientific Research, The First Hospital of Hebei Medical University, Shijiazhuang, China Department of Pathology, The First Hospital of Hebei Medical University, Shijiazhuang, China.
authors.forename: Zhen-Long
authors.initials: ZL
authors.lastname: Zhu
authors.forename: Zeng-Ren
authors.initials: ZR
authors.lastname: Zhao
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Yang
authors.forename: Zheng-Min
authors.initials: ZM
authors.lastname: Wang
authors.forename: Dong-Sheng
authors.initials: DS
authors.lastname: Cui
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Wang
authors.forename: Jörg
authors.initials: J
authors.lastname: Kleeff
authors.forename: Hany
authors.initials: H
authors.lastname: Kayed
authors.forename: Bao-Yong
authors.initials: BY
authors.lastname: Yan
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Sun
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D015854:Up-Regulation
chemical_list: C091777:FXYD3 protein, human; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D000254:Sodium-Potassium-Exchanging ATPase