title: First case of multidrug-resistant tuberculosis caused by a rare "Beijing-like" genotype of Mycobacterium tuberculosis in Bogotá, Colombia.
abstract: This report describes a first case due to a genetically distinct and relatively rare "Beijing-like" strain of Mycobacterium tuberculosis isolated from a 15 years old female patient who died shortly after the initiation of antituberculous therapy with second-line drugs. Positive cultures obtained from lung, kidney and adrenal glands upon autopsy were identified as Mycobacterium tuberculosis complex characterized by an identical 15-banded IS6110-RFLP pattern, and were found to be resistant to all the 4 first-line antituberculous drugs tested (rifampin, isoniazid, ethambutol and streptomycin). Spoligotyping followed by comparison with the SITVIT2 database revealed that the isolate belonged to a rare pattern identified as Spoligotype International Type SIT190, which represents only 1.7% of all the Beijing strains worldwide. We present data on its worldwide distribution and present an evolutionary scenario based on available MIRU typing data.
authors.affiliation: Departamento de Microbiología, Facultad de Medicina, Universidad Nacional de Colombia, Bogotá, Colombia. mimurciaa@unal.edu.co
authors.forename: Martha I
authors.initials: MI
authors.lastname: Murcia
authors.forename: Marina
authors.initials: M
authors.lastname: Manotas
authors.forename: Yesica J
authors.initials: YJ
authors.lastname: Jiménez
authors.forename: Johana
authors.initials: J
authors.lastname: Hernández
authors.forename: Maria Irene Cerezo
authors.initials: MI
authors.lastname: Cortès
authors.forename: Lilia E
authors.initials: LE
authors.lastname: López
authors.forename: Thierry
authors.initials: T
authors.lastname: Zozio
authors.forename: Nalin
authors.initials: N
authors.lastname: Rastogi
mesh_terms: D000293:Adolescent; D000995:Antitubercular Agents / Q000627:therapeutic use; D015373:Bacterial Typing Techniques; D003105:Colombia; D005260:Female; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents