title: The reliability and validity of a modified total neuropathy score-reduced and neuropathic pain severity items when used to measure chemotherapy-induced peripheral neuropathy in patients receiving taxanes and platinums.
abstract: BACKGROUND
  Assessment of chemotherapy-induced peripheral neuropathy signs and symptoms has been hampered because of the lack of simple, reliable, and valid measures.
  
  
  OBJECTIVE
  The study objective was to examine the internal consistency and interrater reliability as well as the structural validity of a 5-component total neuropathy score-reduced (TNSr) variant and a chemotherapy-induced neuropathy-specific Neuropathic Pain Scale.
  
  
  METHODS
  One hundred seventeen outpatients receiving taxanes or platinums were assessed by a consistent nurse practitioner using the 2 instruments. Ten subjects participated in interrater reliability testing.
  
  
  RESULTS
  Mean scores and SDs for individual items were low. The strength item was deleted because of low interitem correlations and a floor effect. The reflex item was deleted because of low interitem correlations and its negative influence on Cronbach alpha. Pin sensibility was deleted because of low factor loadings. The TNSr-short form and the chemotherapy-induced neuropathy-specific Neuropathic Pain Scale formed 2 distinct factors, providing evidence of structural validity. Cronbach alpha's for the 2 instruments were .80 and .96, respectively. The TNSr interrater reliability results suggested acceptable rater concordance, but minor revisions could further improve scoring precision.
  
  
  CONCLUSIONS
  Clinimetric evidence supports the use of 2 new instruments when monitoring taxane- and platinum-related neuropathy and pain. Further instrument modifications are recommended, followed by additional testing in diverse populations.
  
  
  CONCLUSIONS
  With these new instruments, nurses can more easily incorporate prospective neuropathy assessment into daily clinical practice. The outcome will be improved symptom awareness by oncology clinicians and patients, leading to fewer chemotherapy-induced peripheral neuropathy-related devastating effects on functionality and quality of life.
authors.affiliation: University of Michigan School of Nursing, Ann Arbor, MI 48109-5482, USA. Ellenls@umich.edu
authors.forename: Ellen M Lavoie
authors.initials: EM
authors.lastname: Smith
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Cohen
authors.forename: Marjorie A
authors.initials: MA
authors.lastname: Pett
authors.forename: Susan L
authors.initials: SL
authors.lastname: Beck
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects*; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000379:methods / Q000451:nursing / Q000592:standards; D009513:New Hampshire; D009515:New Jersey; D009722:Nurse Practitioners; D009730:Nursing Assessment / Q000379:methods / Q000592:standards; D015403:Nursing Evaluation Research; D015588:Observer Variation; D009859:Oncology Nursing; D010147:Pain Measurement / Q000379:methods* / Q000592:standards; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced / Q000175:diagnosis; D017671:Platinum Compounds / Q000009:adverse effects*; D011594:Psychometrics; D012720:Severity of Illness Index; D016037:Single-Blind Method; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires / Q000592:standards; D043823:Taxoids / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D017671:Platinum Compounds; D043823:Taxoids