Growth and associations between auxology, caregiving environment, and cognition in socially deprived Romanian children randomized to foster vs ongoing institutional care.
OBJECTIVE
To determine effects of improved nurturing compared with institutional care on physical growth and to investigate the association between growth and cognitive development.


METHODS
A randomized controlled trial beginning in infants (mean age, 21.0 months; range, 5-32 months), with follow-up at 30, 42, and 54 months of age.


METHODS
Institutionalized and community children in Bucharest, Romania.


METHODS
One hundred thirty-six healthy institutionalized children from 6 orphanages and 72 typically developing, never-institutionalized children.


METHODS
Institutionalized children were randomly assigned to receive foster care or institutional care as usual.


METHODS
Auxology and measures of intelligence over time.


RESULTS
Growth in institutionalized children was compromised, particularly in infants weighing less than 2500 g at birth. Mean height and weight, though not head size, increased to near normal within 12 months in foster care. Significant independent predictors for greater catch-up in height and weight included age younger than 12 months at randomization, lower baseline z scores, and higher caregiving quality, particularly caregiver sensitivity and positive regard. Baseline developmental quotient, birth weight, and height catch-up were significant independent predictors of cognitive abilities at follow-up. Each incremental increase of 1 in standardized height scores between baseline and 42 months was associated with a mean increase of 12.6 points (SD, 4.7 points) in verbal IQ (P < .05).


CONCLUSIONS
Foster care had a significant effect on growth, particularly with early placement and high-quality care. Growth and IQ in low-birth-weight children are particularly vulnerable to social deprivation. Catch-up growth in height under more nurturing conditions is a useful indicator of caregiving quality and cognitive improvement.
Johnson
Dana E
DE
Department of Pediatrics, Division of Neonatology, 420 Delaware St SE, Minneapolis, MN 55455, USA. johns008@umn.edu
Guthrie
Donald
D
Smyke
Anna T
AT
Koga
Sebastian F
SF
Fox
Nathan A
NA
Zeanah
Charles H
CH
Nelson
Charles A
CA
D000886:Anthropometry; D017028:Caregivers; D002674:Child, Institutionalized; D002675:Child, Preschool; D003071:Cognition; D005260:Female; D005500:Follow-Up Studies; D005581:Foster Home Care; D006130:Growth Disorders; D006801:Humans; D007223:Infant; D008297:Male; D019372:Orphanages; D012383:Romania; D012934:Social Isolation