Endoplasmic reticulum stress and atherosclerosis.
Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to human health worldwide. Despite important progress in prevention and treatment, these conditions still account for one third of all deaths annually. Often presented together with obesity, insulin resistance and type 2 diabetes, these chronic diseases are strongly influenced by pathways that lie at the interface of chronic inflammation and nutrient metabolism. Here I discuss recent advances in the study of endoplasmic reticulum stress as one mechanism that links immune response with nutrient sensing in the pathogenesis of atherosclerosis and its complications.
Hotamisligil
Gökhan S
GS
Department of Genetics, and the Broad Institute of Massachusetts Institute of Technology and Harvard, Harvard School of Public Health, Boston, Massachusetts, USA. ghotamis@hsph.harvard.edu
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D050197:Atherosclerosis / Q000209:etiology*; D004721:Endoplasmic Reticulum / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D050356:Lipid Metabolism / Q000502:physiology; D008264:Macrophages / Q000502:physiology; D013312:Stress, Physiological / Q000502:physiology*; D056811:Unfolded Protein Response / Q000502:physiology