title: Temporal stability of urinary and plasma biomarkers of tobacco smoke exposure among cigarette smokers.
abstract: Intraindividual variability of measurements of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), nicotine, cotinine, and r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT) over time is uncertain. From 70 habitual smokers' plasma and urine sampled bimonthly for a year we analysed plasma for NNAL, cotinine and PheT, and urine for NNAL, cotinine and nicotine. We estimated the intraclass correlation coefficients (rho(I)) for each measurement. Plasma and creatinine-corrected urinary NNAL were stable (rho(I) > or =70%); plasma PheT and plasma and urinary total cotinine were fairly stable (rho(I) > or =50%), but urinary nicotine rho(I) approximately 40% was not. Except for nicotine, single measurements from plasma or urine adequately represent individual mean exposure over time.
authors.affiliation: Division of Environmental Health Sciences, University of Minnesota School of Public Health, Minneapolis, MN 55455, USA. trc@cccs.umn.edu
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Church
authors.forename: Kristin E
authors.initials: KE
authors.lastname: Anderson
authors.forename: Chap
authors.initials: C
authors.lastname: Le
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Diane M
authors.initials: DM
authors.lastname: Kampa
authors.forename: Adam R
authors.initials: AR
authors.lastname: Benoit
authors.forename: Andrea R
authors.initials: AR
authors.lastname: Yoder
authors.forename: Steven G
authors.initials: SG
authors.lastname: Carmella
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Hecht
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis* / Q000097:blood / Q000652:urine; D003367:Cotinine / Q000097:blood / Q000652:urine; D006801:Humans; D008875:Middle Aged; D009538:Nicotine / Q000652:urine; D009602:Nitrosamines / Q000097:blood / Q000652:urine; D010616:Phenanthrenes / Q000097:blood; D011725:Pyridines / Q000097:blood / Q000652:urine; D012907:Smoking / Q000097:blood* / Q000652:urine*; D013995:Time
chemical_list: D015415:Biomarkers; D009602:Nitrosamines; D010616:Phenanthrenes; D011725:Pyridines; C502234:r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene; D009538:Nicotine; C099565:4-(methylnitrosamino)-1-(3-pyridyl)-1-butan-1-ol; D003367:Cotinine