Quantitative analysis of single particle trajectories: mean maximal excursion method.
An increasing number of experimental studies employ single particle tracking to probe the physical environment in complex systems. We here propose and discuss what we believe are new methods to analyze the time series of the particle traces, in particular, for subdiffusion phenomena. We discuss the statistical properties of mean maximal excursions (MMEs), i.e., the maximal distance covered by a test particle up to time t. Compared to traditional methods focusing on the mean-squared displacement we show that the MME analysis performs better in the determination of the anomalous diffusion exponent. We also demonstrate that combination of regular moments with moments of the MME method provides additional criteria to determine the exact physical nature of the underlying stochastic subdiffusion processes. We put the methods to test using experimental data as well as simulated time series from different models for normal and anomalous dynamics such as diffusion on fractals, continuous time random walks, and fractional Brownian motion.
Tejedor
Vincent
V
Physics Department, Technical University of Munich, Garching, Germany.
Bénichou
Olivier
O
Voituriez
Raphael
R
Jungmann
Ralf
R
Simmel
Friedrich
F
Selhuber-Unkel
Christine
C
Oddershede
Lene B
LB
Metzler
Ralf
R
D000465:Algorithms; D001703:Biophysics / Q000379:methods*; D004058:Diffusion; D017709:Fractals; D008055:Lipids / Q000737:chemistry; D008954:Models, Biological; D008968:Molecular Conformation; D009038:Motion; D015203:Reproducibility of Results; D013269:Stochastic Processes; D013997:Time Factors
D008055:Lipids