Acute dichlorvos poisoning induces hemorheological abnormalities in rabbits via oxidative stress.
Dichlorvos is an important insecticide used largely. Some studies have demonstrated that organophosphate pesticide has effects on erythrocyte membrane structures, which is critical to erythrocyte function and hemorheology. The aim of the present study was to explore the effect of oxidative stress on hemorheological changes during dichlorvos poisoning in rabbits. Data indicated that after dichlorvos exposure the hematocrit adjusted viscosity at high shear rate increased and erythrocyte membrane fluidity decreased. Data obtained from plasma showed that lipid peroxidative substance-malonaldehyde was elevated and superoxide dismutase was reduced. In summary, oxidative stress does occur in dichlorvos poisoning and may lead to hemorheological alterations. The changes of hemorheology may be responsible for the pathophysiology of the dichlorvos poisoning.
Zhang
Xiaolan
X
Hemorheology Center, Department of Biophysics, Peking University Health Science Center, Beijing, China.
Yao
Weijuan
W
Jia
Binbin
B
Sun
Dagong
D
Ka
Weibo
W
He
Dongqi
D
Wang
Xifu
X
Wen
Zongyao
Z
D000110:Acetylcholinesterase / Q000097:blood; D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D004006:Dichlorvos / Q000633:toxicity*; D004907:Erythrocyte Deformability / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects; D005340:Fibrinogen / Q000378:metabolism; D006400:Hematocrit; D018056:Hemorheology; D007306:Insecticides / Q000633:toxicity; D015227:Lipid Peroxidation / Q000187:drug effects; D008560:Membrane Fluidity / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D011817:Rabbits; D013482:Superoxide Dismutase / Q000097:blood
D002800:Cholinesterase Inhibitors; D007306:Insecticides; D004006:Dichlorvos; D005340:Fibrinogen; D013482:Superoxide Dismutase; D000110:Acetylcholinesterase