title: An anti-influenza component of the bark of Alnus japonica.
abstract: This study to identify anti-influenza components of the bark of Alnus japonica resulted in the isolation of four lupane-type triterpenes (1-4) and one steroid (5). Their structures were characterized on the basis of physicochemical properties, NMR evidence, and ESI-MS data compared with reported data in the literature. Betulinic aldehyde (3) exhibited a particularly strong anti-influenza effect against KBNP-0028 relative to a positive control.
authors.affiliation: College of Pharmacy, Chungnam National University, Daejeon, 305-764, Korea.
authors.forename: Nguyen Huu
authors.initials: NH
authors.lastname: Tung
authors.forename: Hyuk-Joon
authors.initials: HJ
authors.lastname: Kwon
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Kim
authors.forename: Jeong Chan
authors.initials: JC
authors.lastname: Ra
authors.forename: Jeong Ah
authors.initials: JA
authors.lastname: Kim
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D029661:Alnus / Q000737:chemistry; D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects / Q000473:pathology; D053127:Influenza A Virus, H9N2 Subtype / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes / Q000494:pharmacology; D024301:Plant Bark; D012855:Sitosterols / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D000094062:Betulinic Acid; D000094042:Lupanes
chemical_list: D000998:Antiviral Agents; D053978:Pentacyclic Triterpenes; D012855:Sitosterols; D013256:Steroids; D014315:Triterpenes; C025473:gamma-sitosterol; C002503:betulin; D000094062:Betulinic Acid; C010480:lupeol; D000094042:Lupanes