Releasing properties of proteins on SBA-15 spherical nanoparticles functionalized with aminosilanes.
Based on morphology of SBA-15 particles, each has its own synthetic procedure and characteristics, resulting in different adsorption capacity as well as application in drug delivery system. This study focused on the synthesis mesoporous material SBA-15 with spherical morphology. The synthesized mesoporous silica SBA-15 were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), fourier transform infrared (FT-IR), and BET analysis. The release study of original and modified samples were carried out to assess application for controlled drug delivery system. The adsorbed proteins can be readily desorbed on amine-modified samples. Especially, the diamine-modified sample has the highest release amount for two proteins, Lysozyme (LYS) and Myoglobin (MYO).
Kim
Sun-Il
SI
Department of Chemical and Biochemical Engineering, Chosun University, Gwangju 501-759, Korea.
Pham
Thi Tra
TT
Lee
Jae-Wook
JW
Roh
Sung-Hee
SH