The role of LRP8 (ApoER2') in the pathophysiology of the antiphospholipid syndrome.
One of the greatest enigmas in thrombosis research is the observation that one can diagnose a person with a thrombotic risk with a prolongation of the clotting time. Our textbooks have taught us that prolongation of clotting correlates with a tendency to bleed. To confuse our textbook knowledge further, the same patients often have a prolonged bleeding time, a diagnostic test to detect a dysfunction in primary haemostasis. In this paper we critically review the literature that tries to explain the contradiction that exists between in-vitro diagnostic tests and the observed clinical manifestations and discuss our current opinion on how antiphospholipid antibodies can disturb the haemostatic balance.
de Groot
P G
PG
Department of Clinical Chemistry and Haematology, University Medical Center, Utrecht, The Netherlands. Ph.G.deGroot@umcutrecht.nl
Derksen
R H W M
RH
Urbanus
R T
RT
D000818:Animals; D017152:Antibodies, Antiphospholipid / Q000276:immunology*; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000276:immunology / Q000503:physiopathology*; D001760:Bleeding Time; D001780:Blood Coagulation Tests / Q000379:methods; D006487:Hemostasis / Q000276:immunology; D006801:Humans; D026502:LDL-Receptor Related Proteins; D018110:Receptors, Lipoprotein / Q000378:metabolism*; D013927:Thrombosis / Q000175:diagnosis / Q000209:etiology; D053482:beta 2-Glycoprotein I / Q000276:immunology
D017152:Antibodies, Antiphospholipid; D026502:LDL-Receptor Related Proteins; D018110:Receptors, Lipoprotein; D053482:beta 2-Glycoprotein I; C098773:low density lipoprotein receptor-related protein 8