Targeting resveratrol to mitochondria for cardiovascular diseases.
Resveratrol, a naturally occurring phytopolyphenol compound, has attracted extensive interest in recent years because of its diverse pharmacological characteristics. Considering the central role of mitochondria in cell signaling, growth and death, in the present paper we have tried to summarize the present data including patents and discuss the beneficial effects of resveratrol on cardiovascular diseases from the mitochondria perspective.
Fan
Enguo
E
Institute of Biochemistry and Molecular Biology, Freiburg University, Stefan-Meier-Strasse 19, 79104 Freiburg, Germany. fan@pflanzenphys.uni-halle.de
Zhang
Kai
K
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D002318:Cardiovascular Diseases / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control; D002319:Cardiovascular System / Q000187:drug effects / Q000378:metabolism; D016503:Drug Delivery Systems; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D010330:Patents as Topic; D000077185:Resveratrol; D013267:Stilbenes / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*
D000975:Antioxidants; D013267:Stilbenes; D000077185:Resveratrol