The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: a cohort study of 95 patients with autoimmune thyroid disorders.
Complement mannan-binding lectin (MBL) deficiency is associated with increased susceptibility to infections and autoimmune diseases. Previous studies suggested that the production of MBL is stimulated by thyroid hormones. The aim of our study was to investigate this association in patients with autoimmune thyroid diseases (AITD). Serum levels of MBL and parameters of the thyroid function were determined in 62 patients with Hashimoto's thyroiditis, 33 with Graves' disease and 47 blood donors. Follow-up measurements were performed after 6 to 24 months. MBL2 genotypes were determined using multiplex PCR and compared to 359 healthy Czech individuals. Serum levels of MBL tightly correlated with thyroid hormones, leading to strongly increased MBL levels in hyperthyroidism and decreased levels in hypothyroidism. With normalization of the thyroid function during follow-up, MBL levels decreased or increased respectively. The observed correlations were not due to MBL polymorphisms since the frequency of MBL2 polymorphisms in AITD patients was not different from the general population. We conclude that AITD are not associated with MBL polymorphisms. However, the MBL production is strongly dependent on thyroid function, regardless of the genotype.
Potlukova
Eliska
E
Third Department of Medicine, General University Hospital and First Faculty of Medicine, Charles University in Prague, Czech Republic. eliska.potlukova@seznam.cz
Jiskra
Jan
J
Freiberger
Tomas
T
Limanova
Zdenka
Z
Zivorova
Dana
D
Malickova
Karin
K
Springer
Drahomira
D
Grodecka
Lucie
L
Antosova
Marie
M
Telicka
Zdenek
Z
Pesickova
Satu Sinikka
SS
Trendelenburg
Marten
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002097:C-Reactive Protein / Q000378:metabolism; D018153:Czech Republic; D005260:Female; D005838:Genotype; D006111:Graves Disease / Q000097:blood*; D050031:Hashimoto Disease / Q000097:blood*; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000097:blood* / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D055815:Young Adult
C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin; D013963:Thyroid Hormones; D014284:Triiodothyronine; D013972:Thyrotropin; D002097:C-Reactive Protein; D013974:Thyroxine