Nitric oxide inhibits the formation of zinc protoporphyrin IX and protoporphyrin IX.
The aim of this study was to elucidate the mechanism by which curing agents, especially nitrite, inhibit the formation of zinc protoporphyrin IX (ZPP) in dry-cured hams such as Parma ham. The oxidation-reduction potential of model solutions was increased by the addition of nitrite, but it was not clear whether the formation of ZPP is inhibited by the oxidizing property of nitrite. The effect of nitric oxide (NO) produced from nitrite on the formation of ZPP was examined. The amount of ZPP formed was decreased by the addition of NO donors. The amount of protoporphyrin IX (PPIX), which is the precursor of ZPP, was also decreased by the addition of NO donors. It is concluded that NO produced from nitrite inhibited the formation of PPIX and ZPP was therefore not formed in cured meat products with the addition of nitrite or nitrate.
Wakamatsu
Jun-ichi
J
Division of Bio-systems Sustainability, Graduate School of Agriculture, Hokkaido University, Sapporo, Hokkaido, Japan. jwaka@anim.agr.hokudai.ac.jp
Hayashi
Nobutaka
N
Nishimura
Takanori
T
Hattori
Akihito
A
D000818:Animals; D002614:Chelating Agents / Q000737:chemistry; D005519:Food Preservation; D005520:Food Preservatives / Q000737:chemistry*; D008460:Meat / Q000032:analysis*; D008956:Models, Chemical; D009569:Nitric Oxide / Q000737:chemistry*; D020030:Nitric Oxide Donors / Q000737:chemistry; D009994:Osmolar Concentration; D010084:Oxidation-Reduction; D011524:Protoporphyrins / Q000737:chemistry*; D012977:Sodium Nitrite / Q000037:antagonists & inhibitors / Q000737:chemistry*; D034421:Sus scrofa
D002614:Chelating Agents; D005520:Food Preservatives; D020030:Nitric Oxide Donors; D011524:Protoporphyrins; C017803:zinc protoporphyrin; D009569:Nitric Oxide; C028025:protoporphyrin IX; D012977:Sodium Nitrite