title: Exploration of secondary and tertiary pharmacophores in unsymmetrical N,N'-diaryl urea inhibitors of soluble epoxide hydrolase.
abstract: The impact of various secondary and tertiary pharmacophores on in vitro potency of soluble epoxide hydrolase (sEH) inhibitors based on the unsymmetrical urea scaffold 1 is discussed. N,N'-Diaryl urea inhibitors of soluble epoxide hydrolase exhibit subtle variations in inhibitory potency depending on the secondary pharmacophore but tolerate considerable structural variation in the second linker/tertiary pharmacophore fragment.
authors.affiliation: Arête Therapeutics, Inc., 7000 Shoreline Court, South San Francisco, CA 94080, USA. anandan30@yahoo.com
authors.forename: Sampath-Kumar
authors.initials: SK
authors.lastname: Anandan
authors.forename: Richard D
authors.initials: RD
authors.lastname: Gless
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D004851:Epoxide Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008956:Models, Chemical; D008958:Models, Molecular; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D014508:Urea; D004851:Epoxide Hydrolases