title: Parkinson's disease-associated DJ-1 modulates innate immunity signaling in Caenorhabditis elegans.
abstract: DJ-1 is a neuroprotective gene mutated in recessive Parkinson's disease (PD). In addition to direct protective functions in neurons, DJ-1 regulates neuroinflammatory signaling in primary mouse brain astrocytes. To assess the influence of DJ-1 on innate immunity signaling in vivo, we have generated djr-1 knockout Caenorhabditis elegans. When grown on pathogenic gram-negative bacteria, djr-1 (-/-) worms showed stronger phosphorylation of p38 mitogen-activated protein kinase (PMK-1) and hyper-induction of PMK-1 target genes. Thus, PD-associated DJ-1 contributes to regulation of innate immunity.
authors.affiliation: Laboratory of Functional Neurogenetics, Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, German Center for Neurodegenerative Diseases, University of Tübingen, Otfried-Müller-Strasse 27, 72076 Tübingen, Germany.
authors.forename: Elena M
authors.initials: EM
authors.lastname: Cornejo Castro
authors.forename: Jens
authors.initials: J
authors.lastname: Waak
authors.forename: Stephanie S
authors.initials: SS
authors.lastname: Weber
authors.forename: Fabienne C
authors.initials: FC
authors.lastname: Fiesel
authors.forename: Philipp
authors.initials: P
authors.lastname: Oberhettinger
authors.forename: Monika
authors.initials: M
authors.lastname: Schütz
authors.forename: Ingo B
authors.initials: IB
authors.lastname: Autenrieth
authors.forename: Wolfdieter
authors.initials: W
authors.lastname: Springer
authors.forename: Philipp J
authors.initials: PJ
authors.lastname: Kahle
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics / Q000276:immunology* / Q000378:metabolism*; D029742:Caenorhabditis elegans Proteins / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology; D055786:Gene Knockout Techniques; D007113:Immunity, Innate / Q000235:genetics*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D010300:Parkinson Disease / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D010766:Phosphorylation / Q000502:physiology; D015398:Signal Transduction / Q000276:immunology*; D029961:Zebrafish Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D029742:Caenorhabditis elegans Proteins; D009419:Nerve Tissue Proteins; D029961:Zebrafish Proteins; C515379:park7 protein, zebrafish; D020928:Mitogen-Activated Protein Kinases; C463460:Pmk-1 protein, C elegans