Genetic variants of DNA repair gene XPC modulating susceptibility to cervical cancer in North India.
The objective of the study was to investigate the association of Xeroderma Pigmentoum group C (XPC) Lys939Gln (A > C) and poly (AT) insertion deletion (PAT -/+) gene polymorphism with the risk of cervical cancer. We enrolled 220 cervical cancer patients and 237 healthy individuals. Polymorphism for XPC gene (Lys939Gln, PAT -/+) was genotyped by polymerase chain reaction and restriction fragment length polymorphism method. XPC Lys939Gln CC genotype was associated with elevated risk of cervical cancer (OR = 2.15, p = 0.036). CC genotype of Lys939Gln (OR = 3.68; p = 0.02) and +/+ genotype of PAT (OR = 7.99; p = 0.01) were observed to have statistically significant elevated risk in stage IV of cervical cancer. Among tobacco users, carriers of the +/+ genotype of PAT showed a borderline significance (OR = 3.72, p = 0.032). Haplotypes A+ and C- (A > C of Lys939Gln, --> + of PAT) were significantly associated with higher susceptibility to cervical cancer (OR = 2.01, p = 0.005 and OR = 1.76, p = 0.002, respectively). Polymorphisms and haplotypes in XPC appear to influence cervical cancer risk and may modify risk attributable to tobacco usage.
Gangwar
Ruchika
R
Department of Urology and Renal Transplantation, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
Mittal
Balraj
B
Srivastava
Shruti
S
Singh
Hariom
H
Mittal
Rama Devi
RD
D004260:DNA Repair / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007194:India; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking / Q000235:genetics; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology
D004268:DNA-Binding Proteins; C086984:XPC protein, human