[Efficacy evaluation of lafutidine for mild reflux esophagitis in Japanese patients].
To evaluate the efficacy of lafutidine (20mg) , famotidine (40mg) and placebo in patients with mild reflux esophagitis (Grades A and B according to the Los Angeles classification) , a double-blind, multicenter, randomized clinical trial was performed for the first time in Japanese patients. In addition to each physician's evaluation, efficacy was evaluated by judging panels using images submitted by each physician. The healing rate after 8 weeks for lafutidine, famotidine and placebo were 67.7%, 56.6% and 41.2%, respectively. Lafutidine was significantly more effective than placebo (p=0.002, according to the judging panels) . Based on the evaluation of endoscopic images by the judging panels, 91 (27.1%) of 336 images submitted by each physician were judged to not be mucosal breaks. Judging panels are considered one of the ways to resolve the problem of the need to unify the criteria.
Ohara
Shuichi
S
Department of Gastroenterology, Tohoku Rosai Hospital, Japan. sohara1122@tohokuh.rofuku.go.jp
Haruma
Ken
K
Kinoshita
Yoshikazu
Y
Kusano
Motoyasu
M
D000081:Acetamides / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D044466:Asian People; D004942:Esophagitis, Peptic / Q000188:drug therapy*; D015738:Famotidine / Q000627:therapeutic use; D005260:Female; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*
D000081:Acetamides; D006635:Histamine H2 Antagonists; D010880:Piperidines; D011725:Pyridines; C076948:lafutidine; D015738:Famotidine