Spatial learning sculpts the dendritic arbor of adult-born hippocampal neurons.
Neurogenesis in the hippocampus is characterized by the birth of thousand of cells that generate neurons throughout life. The fate of these adult newborn neurons depends on life experiences. In particular, spatial learning promotes the survival and death of new neurons. Whether learning influences the development of the dendritic tree of the surviving neurons (a key parameter for synaptic integration and signal processing) is unknown. Here we show that learning accelerates the maturation of their dendritic trees and their integration into the hippocampal network. We demonstrate that these learning effects on dendritic arbors are homeostatically regulated, persist for several months, and are specific to neurons born during adulthood. Finally, we show that this dendritic shaping depends on the cognitive demand and relies on the activation of NMDA receptors. In the search for the structural changes underlying long-term memory, these findings lead to the conclusion that shaping neo-networks is important in forming spatial memories.
Tronel
Sophie
S
Institut National de la santé et de la Recherche Médicale, Unité 862, Neurocentre Magendie, Neurogenesis and Pathophysiology Group, 33077 Bordeaux, France. sophie.tronel@inserm.fr
Fabre
Annabelle
A
Charrier
Vanessa
V
Oliet
Stéphane H R
SH
Gage
Fred H
FH
Abrous
Djoher Nora
DN
D000704:Analysis of Variance; D000818:Animals; D003712:Dendrites / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology*; D007150:Immunohistochemistry; D007858:Learning / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000166:cytology*; D009483:Neuropsychological Tests; D051381:Rats; D017207:Rats, Sprague-Dawley; D013028:Space Perception / Q000502:physiology*