Traffic of cytoskeletal motors with disordered attachment rates.
Motivated by experimental results on the interplay between molecular motors and tau proteins, we extend lattice-based models of intracellular transport to include a second species of particle which locally influences the motor-filament attachment rate. We consider various exactly solvable limits of a stochastic multiparticle model before focusing on the low-motor-density regime. Here, an approximate treatment based on the random-walk behavior of single motors gives good quantitative agreement with simulation results for the tau dependence of the motor current. Finally, we discuss the possible physiological implications of our results.
Grzeschik
H
H
Fachrichtung Theoretische Physik, Universität des Saarlandes, 66041 Saarbrücken, Germany. rosemary.harris@qmul.ac.uk
Harris
R J
RJ
Santen
L
L
D001665:Binding Sites; D003198:Computer Simulation; D003599:Cytoskeleton / Q000737:chemistry* / Q000502:physiology*; D008954:Models, Biological; D008956:Models, Chemical; D020409:Molecular Motor Proteins / Q000737:chemistry* / Q000502:physiology*; D009038:Motion; D011485:Protein Binding
D020409:Molecular Motor Proteins