title: Optical-fiber-microsphere for remote fluorescence correlation spectroscopy.
abstract: Fluorescence correlation spectroscopy (FCS) is a versatile method that would greatly benefit to remote optical-fiber fluorescence sensors. However, the current state-of-the-art struggles with high background and low detection sensitivities that prevent the extension of fiber-based FCS down to the single-molecule level. Here we report the use of an optical fiber combined with a latex microsphere to perform FCS analysis. The sensitivity of the technique is demonstrated at the single molecule level thanks to a photonic nanojet effect. This offers new opportunities for reducing the bulky microscope setup and extending FCS to remote or in vivo applications.
authors.affiliation: Institut Fresnel, CNRS, Aix-Marseille Université, Ecole Centrale Marseille, Campus de St Jérôme, 13397 Marseille, France.
authors.forename: Heykel
authors.initials: H
authors.lastname: Aouani
authors.forename: Frédérique
authors.initials: F
authors.lastname: Deiss
authors.forename: Jérôme
authors.initials: J
authors.lastname: Wenger
authors.forename: Patrick
authors.initials: P
authors.lastname: Ferrand
authors.forename: Neso
authors.initials: N
authors.lastname: Sojic
authors.forename: Hervé
authors.initials: H
authors.lastname: Rigneault