Memory formation: from network structure to neural dynamics.
Understanding the neural correlates of brain function is an extremely challenging task, since any cognitive process is distributed over a complex and evolving network of neurons that comprise the brain. In order to quantify observed changes in neuronal dynamics during hippocampal memory formation, we present metrics designed to detect directional interactions and the formation of functional neuronal ensembles. We apply these metrics to both experimental and model-derived data in an attempt to link anatomical network changes with observed changes in neuronal dynamics during hippocampal memory formation processes. We show that the developed model provides a consistent explanation of the anatomical network modifications that underlie the activity changes observed in the experimental data.
Feldt
Sarah
S
Physics Department, University of Michigan, Ann Arbor, MI 48109, USA.
Wang
Jane X
JX
Hetrick
Vaughn L
VL
Berke
Joshua D
JD
Zochowski
Michal
M
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D016000:Cluster Analysis; D003198:Computer Simulation; D004566:Electrodes; D006624:Hippocampus / Q000033:anatomy & histology / Q000166:cytology / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D009043:Motor Activity / Q000502:physiology; D009415:Nerve Net / Q000033:anatomy & histology / Q000166:cytology / Q000502:physiology*; D009474:Neurons / Q000166:cytology*; D012890:Sleep / Q000502:physiology; D013569:Synapses / Q000378:metabolism; D013997:Time Factors