title: A case of rapid progression and vision loss in a patient with primary intraocular lymphoma.
abstract: OBJECTIVE
  To describe an atypical case of primary intraocular lymphoma (PIOL) with rapid progression leading to vision loss and death.
  
  
  METHODS
  A 71-year-old woman with a history of PIOL presented with a sudden decline in vision. MRI, CSF cytology, and ocular examination 2 months prior were unremarkable.
  
  
  RESULTS
  Repeat MRI of the brain and orbits at this time revealed a 0.8 x 2.4-cm lesion of the left choroid plexus. LP revealed rare atypical B cells. The patient rapidly deteriorated and died a month later.
  
  
  CONCLUSIONS
  Recognition of the potential for rapid progression and mortality in patients with PIOL is essential.
authors.affiliation: Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland 20892-1857, USA.
authors.forename: Amit
authors.initials: A
authors.lastname: Sangave
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Faia
authors.forename: Steven
authors.initials: S
authors.lastname: Yeh
authors.forename: Chi-Chao
authors.initials: CC
authors.lastname: Chan
authors.forename: Robert B
authors.initials: RB
authors.lastname: Nussenblatt
authors.forename: H Nida
authors.initials: HN
authors.lastname: Sen
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D001766:Blindness / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D018450:Disease Progression; D005134:Eye Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D011344:Procarbazine; D014750:Vincristine; D008727:Methotrexate