title: Acute lymphoblastic leukemia complicated by acute renal failure: a case report and review of the literature.
abstract: The patient, a previously healthy woman, presenting with acute renal failure and anemia, was admitted to our hospital. Her serum creatinine (Scr) had increased from 0.79 - 2.69 mg/dl over three days and hemoglobin had decreased from 12.1 - 7.8 g/dl over 4 weeks. Mild compression fracture and degeneration of the lumbar vertebra and skull were observed in X-ray. The renal biopsy showed acute proximal tubular lesions induced by multiple calcium deposition. A bone marrow biopsy showed that primitive lymphocyte was up to 92.5%. After making a diagnosis of acute lymphoblastic leukemia complicated with acute kidney injury induced by hypercalcemia, CRRT (continued renal replacement therapy) and chemotherapy were used immediately. Ten days later, the blood calcium had gradually decreased from 3.88 to normal range (1.8 mmol/l) and the renal function was back to normal (Scr 0.93 mg/dl). This unusual case shows that a patient who has a syndrome of acute renal failure, electrolyte disturbances, anemia, and elevated LDH needs bone marrow puncture to eliminate renal injury caused by hematologic diseases.
authors.affiliation: Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing, China. zhouyan780101@hotmail.com
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.forename: Z
authors.initials: Z
authors.lastname: Tang
authors.forename: Z-H
authors.initials: ZH
authors.lastname: Liu
authors.forename: L-S
authors.initials: LS
authors.lastname: Li
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D000740:Anemia / Q000150:complications / Q000473:pathology; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications* / Q000473:pathology; D007668:Kidney / Q000473:pathology*; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D016896:Treatment Outcome