The changed metabolic world with human brown adipose tissue: therapeutic visions.
That adult humans possess active brown adipose tissue potentially leads to a paradigm shift in the understanding of human metabolism and of obesity. Adaptive adrenergic thermogenesis in humans represents brown adipose tissue activity, the absence of which may contribute to middle-age obesity.
Nedergaard
Jan
J
The Wenner-Gren Institute, The Arrhenius Laboratories, Stockholm University, SE-10691 Stockholm, Sweden. jan@metabol.su.se
Cannon
Barbara
B
D002001:Adipose Tissue, Brown / Q000502:physiology*; D000375:Aging / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D020738:Leptin / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000378:metabolism*; D008954:Models, Biological; D009765:Obesity / Q000209:etiology* / Q000503:physiopathology; D022722:Thermogenesis / Q000502:physiology*; D000071256:Uncoupling Protein 1
D007473:Ion Channels; D020738:Leptin; D024101:Mitochondrial Proteins; D000071256:Uncoupling Protein 1