Perinatal exposure to bisphenol-a and the development of metabolic syndrome in CD-1 mice.
Bisphenol-A (BPA) is an endocrine-disrupting chemical used in the production of plastic food and beverage containers, leading to ubiquitous low-dose human exposure. It has been suggested that exposure to even low doses of BPA during development may be associated with increased susceptibility to obesity and diabetes later in life. Despite growing public concern, the existing empirical data are equivocal, prompting The Endocrine Society, the National Institute of Environmental Health Sciences, and others to call for further research. In this study, we tested the hypothesis that perinatal exposure to an ecologically relevant dose of BPA (1 part per billion via the diet) results in increased susceptibility to high-fat diet-induced obesity and glucose intolerance in adult CD-1 mice. The data did not support this hypothesis. In agreement with previous reports, we find that weanling mice exposed to BPA during gestation and lactation are heavier compared with control mice. We also find that BPA mice are longer than controls at 4 wk of age, but these differences are no longer apparent when the mice reach adulthood, even when tested on a high-fat diet. We conclude that this larger size-for-age represents a faster rate of growth early in development rather than an obese, diabetic phenotype in adulthood.
Ryan
Karen K
KK
Department of Internal Medicine, Division of Endocrinology, The University of Cincinnati College of Medicine, 2170 East Galbraith Road, Mail Location 0503, Cincinnati, Ohio 45237, USA.
Haller
April M
AM
Sorrell
Joyce E
JE
Woods
Stephen C
SC
Jandacek
Ronald J
RJ
Seeley
Randy J
RJ
D000818:Animals; D019540:Area Under Curve; D001559:Benzhydryl Compounds; D001823:Body Composition; D004968:Estrogens, Non-Steroidal / Q000633:toxicity*; D005260:Female; D005951:Glucose Tolerance Test; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced* / Q000209:etiology*; D051379:Mice; D010636:Phenols / Q000633:toxicity*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced*; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D004968:Estrogens, Non-Steroidal; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds