title: Four-component domino reaction providing an easy access to multifunctionalized tricyclo[6.2.2.0(1,6)]dodecane derivatives.
abstract: A novel four-component domino reaction has been discovered. The reaction is easy to perform simply by mixing four common reactants and Cs(2)CO(3) in ethylene glycol under microwave heating. The reaction proceeds at fast rates and can be finished within 15-24 min, which makes workup convenient. Four stereogenic centers with one quaternary carbon-amino function have been controlled completely. The stereochemistry has been unequivocally determined by X-ray structural analysis. The resulting tricyclo[6.2.2.0(1,6)]dodecane derivatives are of importance for organic and medicinal research.
authors.affiliation: School of Chemistry and Chemical Engineering, Xuzhou Normal University, Xuzhou, 221116, Jiangsu, People's Republic of China.
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Shi
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
authors.forename: Parminder
authors.initials: P
authors.lastname: Kaur
authors.forename: Walter
authors.initials: W
authors.lastname: Wever
authors.forename: Guigen
authors.initials: G
authors.lastname: Li
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis*; D002254:Carbonates / Q000737:chemistry*; D002586:Cesium / Q000737:chemistry*; D019855:Ethylene Glycol / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: D000473:Alkanes; D002254:Carbonates; D011083:Polycyclic Compounds; C007548:n-dodecane; D002586:Cesium; D019855:Ethylene Glycol; C545311:cesium carbonate