title: 1H, 13C, and 15N resonance assignment of the TIR domain of human MyD88.
abstract: Myeloid differentiating factor 88 (MyD88) is one of a critical adaptor molecule in the Toll-like receptor (TLR) signaling pathway. The TIR domain of MyD88 serves as a protein-protein interaction module and interacts with other TIR-containing proteins such as Mal (MyD88 adaptor-like) and Toll-like receptor 4 to form signal initiation complexes. Here we report the (15)N, (13)C, and (1)H chemical shift assignments of the TIR domain of MyD88. The resonance assignments obtained in this work will contribute to the study of heteromeric TIR-TIR interactions between MyD88 and TIR-containing receptors or adaptors.
authors.affiliation: Department of Pediatrics, Graduate School of Medicine, Gifu University, Yanagido 1-1, Gifu, 501-1194, Japan. ohnishih@gifu-u.ac.jp
authors.forename: Hidenori
authors.initials: H
authors.lastname: Ohnishi
authors.forename: Hidehito
authors.initials: H
authors.lastname: Tochio
authors.forename: Zenichiro
authors.initials: Z
authors.lastname: Kato
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kimura
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Hiroaki
authors.forename: Naomi
authors.initials: N
authors.lastname: Kondo
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shirakawa
mesh_terms: D002247:Carbon Isotopes; D006801:Humans; D006859:Hydrogen; D053594:Myeloid Differentiation Factor 88 / Q000737:chemistry*; D009587:Nitrogen Isotopes; D019906:Nuclear Magnetic Resonance, Biomolecular; D017434:Protein Structure, Tertiary
chemical_list: D002247:Carbon Isotopes; D053594:Myeloid Differentiation Factor 88; D009587:Nitrogen Isotopes; D006859:Hydrogen