Monte carlo simulation of heterotypic cell aggregation in nonlinear shear flow.
In this paper, we develop a population balance model for cell aggregation and adhesion process in a nonuniform shear flow. Some Monte Carlo simulation results based on the model are presented for the heterotypic cell-cell collision and adhesion to a substrate under dynamic shear forces. In particular, we focus on leukocyte (PMN)-melanoma cell emboli formation and subsequent tethering to the vascular endothelium (EC) as a result of cell-cell aggregation. The simulation results are compared with the results of experimental measurement. Discussions are made on how we could further improve the accuracy of the population balance type modelling.
Wang
Jiakou
J
Department of Mathematics, Penn State University, University Park, PA 16802. jiakou@math.psu.edu.
Slattery
Margaret J
MJ
Hoskins
Meghan Henty
MH
Liang
Shile
S
Dong
Cheng
C
Du
Qiang
Q