Influencing factors of QTc among the clinical characteristics in type 2 diabetes mellitus.
OBJECTIVE
Although the clinical implications of prolonged Q-T interval have been described, the clinical determinants of Q-T interval in type 2 diabetes mellitus are not clear. We examined the influencing factors of QTc in type 2 diabetes mellitus.


METHODS
This study involved 207 patients with type 2 diabetes mellitus and 141 healthy controls. QTc was estimated from resting lead II electrocardiogram. Data analysis was done using unpaired Student's 't' and Pearson correlation tests.


RESULTS
Only female diabetics with somatic neuropathy had longer QTc compared to controls (p<0.01). Only in male diabetics negative correlation was found between QTc and heart rate response to deep breathing (p<0.01). Male and female study subjects with diabetic retinopathy had longer QTc compared to controls (p<0.01, 0.05). Only male diabetics with hypertension had longer QTc compared to controls (p<0.05).


CONCLUSIONS
QTc prolongation is associated with diabetic neuropathy with sex difference in its manifestation. It is influenced by diabetic retinopathy in male and female diabetics. It is influenced by hypertension in male type 2 diabetics.
Subbalakshmi
N K
NK
Department of Physiology, Kasturba Medical College, Light House Hill Road, Hampanakatta, Mangalore 1, Karnataka, India. rao.subbalakshmink@rediffmail.com
Adhikari
P M R
PM
Sathyanarayana Rao
K N
KN
Jeganathan
P S
PS
D000368:Aged; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D003929:Diabetic Neuropathies / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D008133:Long QT Syndrome / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors