Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid.
OBJECTIVE
Lactobionic acid (LA) is a newer cosmeceutical active belonging to the class of alpha-hydroxyacids (AHAs), showing advantages over them. The aim of part I of this study was to compare efficacy and irritation potential of LA vs. glycolic acid (GA) from two types of vehicles - gel and emulsion. In part II, effects of LA-containing emulsions based on a new, natural emulsifier of alkylpolyglucoside (APG) type were evaluated.


METHODS
Skin bioengineering was used on 77 healthy volunteers to assess: color as erythema and melanin (MI) index, transepidermal water loss, electrical capacitance and pH of the skin. In part I of the study, the parameters were measured after occlusion and periodically during 2 weeks of test samples application; in part II parameters were measured periodically during 4 weeks.


CONCLUSIONS
LA-containing samples has produced better skin performance when compared with corresponding GA-containing ones, particularly the lack of both skin irritation and skin barrier impairment. When used in vehicles based on a new APG-emulsifier, LA and GA have shown better efficacy, emphasizing the importance of vehicle on the effects of topical actives. LA (6%) in the emulsion based on APGs could be proposed as an alternative to low-molecular AHAs in cosmeceuticals.
Tasic-Kostov
Marija
M
Department of Pharmacy, School of Medicine, University of Nis, Nis, Serbia.
Savic
Snezana
S
Lukic
Milica
M
Tamburic
Slobodanka
S
Pavlovic
Milos
M
Vuleta
Gordana
G
D000279:Administration, Cutaneous; D000328:Adult; D004187:Disaccharides / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D004655:Emulsions / Q000494:pharmacology; D005233:Fatty Alcohols / Q000494:pharmacology; D005260:Female; D005782:Gels / Q000494:pharmacology; D005960:Glucosides / Q000494:pharmacology; D006016:Glycolates / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D014677:Pharmaceutical Vehicles / Q000494:pharmacology; D012016:Reference Values; D023422:Skin Irritancy Tests; D013473:Sunscreening Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
D004187:Disaccharides; D004655:Emulsions; D005233:Fatty Alcohols; D005782:Gels; D005960:Glucosides; D006016:Glycolates; D007641:Keratolytic Agents; D014677:Pharmaceutical Vehicles; D013473:Sunscreening Agents; C031149:glycolic acid; C005608:lactobionic acid