Nogo-A expresses on neural stem cell surface.
Nogo-A, as a myelin-associated molecule to inhibit axon regeneration in the injured adult central nervous system (CNS), has been detected to be enriched in numerous populations of cells in CNS. In this study, we found that Nogo-A was also expressed on the surface of neural stem cells (NSCs). The possible effects of NSCs-expressed Nogo-A on the NSC transplantation for CNS repair were discussed.
Hou
Teng
T
Institute of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Shi
Ying
Y
Cheng
Shigang
S
Yang
Xiong
X
Li
Lulu
L
Xiao
Chuanguo
C
D000818:Animals; D015153:Blotting, Western; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism; D005786:Gene Expression Regulation; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000235:genetics; D009185:Myelin Proteins / Q000096:biosynthesis* / Q000235:genetics; D009416:Nerve Regeneration; D009474:Neurons / Q000166:cytology* / Q000378:metabolism; D000070798:Nogo Proteins; D051381:Rats; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism; D013119:Spinal Cord Injuries / Q000601:surgery; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000378:metabolism*
D008565:Membrane Proteins; D009185:Myelin Proteins; D000070798:Nogo Proteins; C000603197:Rtn4 protein, rat