title: Reduced clearance of penile human papillomavirus infection in uncircumcised men.
abstract: The relationship between circumcision and the acquisition and clearance of human papillomavirus (HPV) infection was examined in a cohort of 357 men followed up at 2-month intervals for an average of 431 days. There were no differences in HPV acquisition by circumcision status. Clearance of HPV infection, including infection with oncogenic types, was slower in the glans/coronal sulcus of the penis of uncircumcised men than circumcised men. The median duration of HPV infection of the glans/coronal sulcus was significantly longer in uncircumcised men (154 days) than circumcised men (91 days) (P=.04). Circumcision may protect against HPV-associated disease by enhancing the resolution of infection.
authors.affiliation: Cancer Research Center of Hawaii, 1236 Lauhala St, Honolulu, HI 96813, USA. brenda@crch.hawaii.edu
authors.forename: Brenda Y
authors.initials: BY
authors.lastname: Hernandez
authors.forename: Yurii B
authors.initials: YB
authors.lastname: Shvetsov
authors.forename: Marc T
authors.initials: MT
authors.lastname: Goodman
authors.forename: Lynne R
authors.initials: LR
authors.lastname: Wilkens
authors.forename: Pamela
authors.initials: P
authors.lastname: Thompson
authors.forename: Xuemei
authors.initials: X
authors.lastname: Zhu
authors.forename: Lily
authors.initials: L
authors.lastname: Ning
mesh_terms: D000328:Adult; D002944:Circumcision, Male; D052816:Foreskin / Q000821:virology; D006801:Humans; D008297:Male; D027383:Papillomaviridae / Q000378:metabolism*; D030361:Papillomavirus Infections / Q000821:virology*; D010409:Penile Diseases / Q000821:virology*; D010413:Penis / Q000821:virology; D012307:Risk Factors; D013997:Time Factors