title: Exposing viruses: RNA patterns sensed by RIG-I-like receptors.
abstract: BACKGROUND
  Virus infection triggers a multitude of innate immune pathways that limit viral replication, restrict viral spread and coordinate antigen-specific, adaptive immune responses. Type-I interferons (IFNs) play a crucial role in these events. Innate receptors expressed by the host cell recognize virus presence and signal for rapid IFN induction following infection.
  
  
  METHODS
  This review article discusses recent progress in our understanding of how cytoplasmic RIG-I-like receptors detect infection with RNA viruses.
authors.affiliation: Immunobiology Laboratory, Cancer Research UK London Research Institute, 44 Lincoln's Inn Fields, London, WC2A 3PX, UK. jan.rehwinkel@cancer.org.uk
authors.forename: Jan
authors.initials: J
authors.lastname: Rehwinkel
mesh_terms: D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D007370:Interferon Type I / Q000276:immunology; D012328:RNA Viruses / Q000276:immunology*; D011971:Receptors, Immunologic; D051192:Receptors, Pattern Recognition / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology
chemical_list: D007370:Interferon Type I; D011971:Receptors, Immunologic; D051192:Receptors, Pattern Recognition; C452820:RIGI protein, human; D000071457:DEAD Box Protein 58; D053487:DEAD-box RNA Helicases