title: [Growth inhibition and apoptosis-inducing effects of phytic acid in human gastric carcinoma cells].
abstract: OBJECTIVE
  To explore the growth inhibition and apoptosis-inducing effects of phytic acid in human gastric cancer SGC-7901 cells.
  
  
  METHODS
  The growth inhibition action of phytic acid on SGC-7901 cells was examined by MTT assay. AO/EB fluorescence staining and DNA ladder assay were applied to study the proapoptosis effects of phytic acid. The expression of apoptosis relative proteins, P53, were analyzed by using immune histochemisty method.
  
  
  RESULTS
  Phytic acid treatment significantly inhibited the growth of human gastric cancer cell SGC-7901 and markedly caused their apoptosis following downregulation of P53 protein expression.
  
  
  CONCLUSIONS
  The downregulation of apoptosis relative protein P53 expression was the possible mechanism of phytic acid induced growth inhibition and apoptosis in SGC-7901 cells.
authors.affiliation: Harbin Institute of Technology, Harbin 150090, China. wanglu_tianfeng@yahoo.com.cn
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Cuilin
authors.initials: C
authors.lastname: Cheng
authors.forename: Haitian
authors.initials: H
authors.lastname: Zhao
authors.forename: Zhiping
authors.initials: Z
authors.lastname: Yang
authors.forename: Honglian
authors.initials: H
authors.lastname: Wei
authors.forename: Hongbin
authors.initials: H
authors.lastname: Cui
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006801:Humans; D010833:Phytic Acid / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000473:pathology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D010833:Phytic Acid