Morphological development of multilamellar phospholipid film depending on drying kinetics.
The mechanism for the formation of solid-supported phospholipid membranes during a drying process was investigated. Terracelike multilamellar structures were found to develop from a micellar solution with either spinodal decompositionlike process or nucleation growth, depending on the evaporation rate of an organic solvent. In contrast to the well-known kinetics of phase separation, fast drying induces nucleation while slow drying induces spinodal decompositionlike lipid-film formation. The existing models for the interpretation of phase separation are not sufficient to understand this unexpected kinetics. We suggest a schematic model with which this kinetic feature can be interpreted in terms of a self-assembly pathway in a three-component phase diagram for a phospholipid, organic solvent, and water.
Hishida
M
M
Department of Physics, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan. hishida@scphys.kyoto-u.ac.jp
Yamada
N L
NL
Yoshikawa
K
K
Seto
H
H
D003198:Computer Simulation; D003890:Desiccation / Q000379:methods*; D007700:Kinetics; D008051:Lipid Bilayers / Q000737:chemistry*; D008560:Membrane Fluidity; D008567:Membranes, Artificial; D008956:Models, Chemical; D044367:Phase Transition; D010743:Phospholipids / Q000737:chemistry*
D008051:Lipid Bilayers; D008567:Membranes, Artificial; D010743:Phospholipids