title: Sensitivity of zinc kinetics and nutritional assessment of children submitted to venous zinc tolerance test.
abstract: OBJECTIVE
  The purposes of this study were to investigate the kinetics of zinc in schoolchildren between the ages of 6 and 9 years, of both sexes, and to verify its sensitivity in detecting alterations in body zinc status.
  
  
  METHODS
  Nutritional assessment was performed by body mass index. Food intake, venous zinc tolerance test, and zinc kinetics were carried out before and after 3-month oral zinc supplementation.
  
  
  RESULTS
  Of the 42 children studied, 76.2% had healthy weight. Only energy, calcium, and fiber intake were suboptimal before and after oral zinc supplementation. Serum zinc and total-body zinc clearance, although at normal levels, increased significantly after zinc supplementation.
  
  
  CONCLUSIONS
  We concluded, therefore, that kinetics is a sensitive tool for detecting changes in body zinc status, even in children without a deficiency of this mineral. Furthermore, kinetics showed a positive response to supplementation and may be a sensitive parameter for evaluating the efficacy of this therapy.
authors.affiliation: Postgraduate Program in Health Sciences (PPGCSA), Universidade Federal do Rio Grande do Norte (UFRN), Natal-RN, BRAZIL.
authors.forename: Lúcia Dantas
authors.initials: LD
authors.lastname: Leite
authors.forename: Erika Dantas
authors.initials: ED
authors.lastname: de Medeiros Rocha
authors.forename: Maria
authors.initials: M
authors.lastname: das Graças Almeida
authors.forename: Adriana Augusto
authors.initials: AA
authors.lastname: Rezende
authors.forename: Carlos Antônio Bruno
authors.initials: CA
authors.lastname: da Silva
authors.forename: Mardone Cavalcante
authors.initials: MC
authors.lastname: França
authors.forename: Júlio Sérgio
authors.initials: JS
authors.lastname: Marchini
authors.forename: José
authors.initials: J
authors.lastname: Brandão-Neto
mesh_terms: D001798:Blood Proteins / Q000378:metabolism; D015992:Body Mass Index; D002648:Child; D003404:Creatinine / Q000652:urine; D019587:Dietary Supplements; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D015596:Nutrition Assessment; D015032:Zinc / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D001798:Blood Proteins; D006454:Hemoglobins; D003404:Creatinine; D015032:Zinc