title: Preparation and characterization of n-hydroxyapatite/PCL-pluronic-PCL nanocomposites for tissue engineering.
abstract: In this paper, a new kind of polymeric nanocomposite materials based on nano-hydroxyapatite (n-HA) and PCL-Pluronic-PCL (PCFC) copolymer were prepared by in situ combination method. Firstly, the PCFC copolymer was synthesized by ring-opening polymerization of epsilon-caprolactone initiated by Pluronic (PEG-PPG-PEG); Secondly, n-HA powder were combined with PCFC to form polymeric composites in the presence of hexamethylene diisocyanate (HDI). The obtained composites were characterized by 1H-NMR, FTIR, XRD, TEM, SEM, DTA/TGA, and tensile testing. The results revealed that n-HA could be dispersed into polymer matrix uniformly, and the n-HA/PCFC composite showed great mechanical properties when the content of n-HA was 10 wt%. The microstructure and thermal properties of the composites were discussed in the paper too. The experimental results suggested that this polymeric nanocomposite might have great potential application in the field of tissue engineering.
authors.affiliation: State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China.
authors.forename: Shaozhi
authors.initials: S
authors.lastname: Fu
authors.forename: Gang
authors.initials: G
authors.lastname: Guo
authors.forename: Xinlong
authors.initials: X
authors.lastname: Wang
authors.forename: Liangxue
authors.initials: L
authors.lastname: Zhou
authors.forename: Tingting
authors.initials: T
authors.lastname: Liu
authors.forename: Pengwei
authors.initials: P
authors.lastname: Dong
authors.forename: Feng
authors.initials: F
authors.lastname: Luo
authors.forename: Yingchun
authors.initials: Y
authors.lastname: Gu
authors.forename: Xingyu
authors.initials: X
authors.lastname: Shi
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
authors.forename: Yuquan
authors.initials: Y
authors.lastname: Wei
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Qian
mesh_terms: D017886:Durapatite; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D020442:Poloxamer; D017550:Spectroscopy, Fourier Transform Infrared; D023822:Tissue Engineering; D014961:X-Ray Diffraction
chemical_list: D020442:Poloxamer; D017886:Durapatite