Time domain and spectral domain optical coherence tomography in multiple sclerosis: a comparative cross-sectional study.
Conventional time domain optical coherence tomography has been established for the in vivo assessment of retinal axonal loss in multiple sclerosis. The innovative spectral domain imaging is superior to the conventional technique with respect to data acquisition speed, resolution and reproducibility. However, until now comparability of the two techniques has not been investigated in multiple sclerosis. In this study involving 55 multiple sclerosis patients, data obtained using both techniques (Stratus time domain optical coherence tomography and Cirrus spectral domain optical coherence tomography, Carl Zeiss Meditec) showed an excellent correlation (Pearson's r = 0.926, p < 0.001). However, owing to considerable differences in absolute retinal nerve fibre layer measurements (mean +/- standard deviation 8.1 microm +/- 6.2, range -12 to 23 microm), results from the two devices are not interchangeable.
Bock
Markus
M
NeuroCure Clinical Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany, Cecilie Vogt Clinic, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Brandt
Alexander Ulrich
AU
Dörr
Jan
J
Pfueller
Caspar F
CF
Ohlraun
Stephanie
S
Zipp
Frauke
F
Paul
Friedemann
F
D000328:Adult; D001369:Axons / Q000473:pathology*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D004867:Equipment Design; D005260:Female; D005858:Germany; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000503:physiopathology; D011237:Predictive Value of Tests; D055351:Retinal Neurons / Q000473:pathology*; D013997:Time Factors; D041623:Tomography, Optical Coherence / Q000295:instrumentation / Q000379:methods*; D014792:Visual Acuity; D055815:Young Adult