Type B insulin resistance in a systemic lupus erythematosus patient.
In type B insulin resistance and acanthosis nigricans, the insulin resistance is due to the presence of anti-insulin receptor antibody 1. Approximately one-third of patients with these antibodies have an associated illness such as systemic lupus erythematosus (SLE) or Sjögren's syndrome. This report describes a case wherein the patient had presented with uncontrolled diabetes and required > 3000 units of human insulin to control hyperglycemia. She also had features of SLE. There was complete recovery following treatment with steroids.
Ostwal
Vikas
V
Department of Medicine, LTM Medical College & LTMG Hospital, Mumbai, India. dr.vikas.ostwal@gmail.com
Oak
Jyotsna
J
D001323:Autoantibodies / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000276:immunology*; D007328:Insulin / Q000008:administration & dosage / Q000276:immunology*; D007333:Insulin Resistance / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology*; D008875:Middle Aged
D001323:Autoantibodies; D007004:Hypoglycemic Agents; D007328:Insulin