title: Pregnancy increases the growth rates of World Health Organization grade II gliomas.
abstract: Twelve pregnancies in 11 adult women harboring World Health Organization (WHO) grade II gliomas (GIIGs) prior to pregnancy were reviewed to address whether pregnancy affects tumor growth using a quantitative approach of the radiological velocity of diametric expansion (VDE) on successive magnetic resonance images. VDE was significantly increased during pregnancy as compared to prepregnancy (p < 0.001) and to postdelivery (p = 0.012) periods. Pregnancy increases the radiological growth rates of GIIGs. An increase in seizure frequency was observed concomitantly in 40% of cases and further oncological treatment was started after delivery in 25% of cases.
authors.affiliation: Department of Neurosurgery, Sainte-Anne Hospital, 1 rue Cabanis, 75674 Paris Cedex 14, France. johanpallud@hotmail.com
authors.forename: Johan
authors.initials: J
authors.lastname: Pallud
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Mandonnet
authors.forename: Christophe
authors.initials: C
authors.lastname: Deroulers
authors.forename: Denys
authors.initials: D
authors.lastname: Fontaine
authors.forename: Mathilde
authors.initials: M
authors.lastname: Badoual
authors.forename: Laurent
authors.initials: L
authors.lastname: Capelle
authors.forename: Frédérique
authors.initials: F
authors.lastname: Guillet-May
authors.forename: Philippe
authors.initials: P
authors.lastname: Page
authors.forename: Philippe
authors.initials: P
authors.lastname: Peruzzi
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Jouanneau
authors.forename: Marc
authors.initials: M
authors.lastname: Frenay
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Cartalat-Carel
authors.forename: Hugues
authors.initials: H
authors.lastname: Duffau
authors.forename: Luc
authors.initials: L
authors.lastname: Taillandier
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D001932:Brain Neoplasms / Q000145:classification / Q000473:pathology* / Q000503:physiopathology; D049109:Cell Proliferation; D018450:Disease Progression; D005260:Female; D005910:Glioma / Q000145:classification / Q000473:pathology* / Q000503:physiopathology; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D009361:Neoplasm Invasiveness / Q000473:pathology*; D009837:Oligodendroglioma / Q000473:pathology / Q000503:physiopathology; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology* / Q000503:physiopathology; D012640:Seizures / Q000209:etiology / Q000503:physiopathology; D014944:World Health Organization; D055815:Young Adult
chemical_list: D012739:Gonadal Steroid Hormones; D013006:Growth Hormone