title: Cellular fibroma of the ovary containing Leydig cell hyperplasia: a case report.
abstract: Ovarian stromal tumors containing Leydig cell components are rare. Only a few cases of ovarian stromal Leydig cell tumors characterized by clusters of Leydig cells have been reported to date. Here, we present the first case report of a 65-year-old woman with a cellular fibroma of the ovary containing Leydig cell hyperplasia. Microscopic examination revealed the proliferation of spindle cells arranged in intersecting bundles with mild nuclear atypia and an average of 2-3 mitotic figures per ten high-power fields. Multifocal nests of polygonal cells with abundant eosinophilic cytoplasm and round nuclei were seen within the spindle cells. Final pathology of the tumor revealed a cellular fibroma including Leydig cell hyperplasia.
authors.affiliation: Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University, Seoul, Korea.
authors.forename: Bo Sung
authors.initials: BS
authors.lastname: Yoon
authors.forename: Seok Ju
authors.initials: SJ
authors.lastname: Seong
authors.forename: Chong Taik
authors.initials: CT
authors.lastname: Park
authors.forename: Hyun
authors.initials: H
authors.lastname: Park
authors.forename: Jeong Yun
authors.initials: JY
authors.lastname: Shim
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Kim