Effects of SA13353, a transient receptor potential vanilloid 1 agonist, on leukocyte infiltration in lipopolysaccharide-induced acute lung injury and ovalbumin-induced allergic airway inflammation.
We recently demonstrated that SA13353, a transient receptor potential vanilloid 1 (TRPV1) agonist, reduced the severity of the symptoms of kidney injury, arthritis, and encephalomyelitis in disease models. Here, we investigated the effects of orally administered SA13353 on leukocyte infiltration in lipopolysaccharide (LPS)-induced acute lung injury and ovalbumin-induced allergic airway inflammation. In LPS-induced lung injury, SA13353 attenuated neutrophil infiltration and the increase of TNF-alpha and CINC-1 levels. In allergic airway inflammation, SA13353 tended to inhibit leukocyte infiltration and attenuated the increase of IL-4 and IL-12p40. These results suggest that somatosensory TRPV1 may play an anti-inflammatory role in lung inflammation.
Tsuji
Fumio
F
Research and Development Center, Santen Pharmaceutical Co., Ltd., Japan. ftsuji@minuet.plala.or.jp
Murai
Masaaki
M
Oki
Kenji
K
Inoue
Hiroyuki
H
Sasano
Minoru
M
Tanaka
Hiroyuki
H
Inagaki
Naoki
N
Aono
Hiroyuki
H
D000818:Animals; D007249:Inflammation / Q000139:chemically induced*; D007962:Leukocytes / Q000166:cytology*; D008070:Lipopolysaccharides / Q000633:toxicity*; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D010047:Ovalbumin / Q000633:toxicity*; D011725:Pyridines / Q000494:pharmacology*; D050916:TRPV Cation Channels / Q000819:agonists*; D014132:Trachea / Q000187:drug effects* / Q000473:pathology; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
C530925:1-(2-(1-adamantyl)ethyl)-1-pentyl-3-(3-(4-pyridyl)propyl)urea; D008070:Lipopolysaccharides; D011725:Pyridines; D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse; D014508:Urea; D010047:Ovalbumin