title: Molecular Medicine - CHI's 17th International Tri-Conference: Mastering Medicinal Chemistry - CHI's Seventh Annual Conference.
abstract: CHI's 17th International Tri-Conference on Molecular Medicine, held in San Francisco, included topics covering new developments in the field of medicinal chemistry. This conference report highlights selected presentations on fragment-based drug discovery, quantum mechanical energy decomposition for the analysis of SARs, medicinal chemistry strategies and the role of imaging in drug discovery. Investigational drugs discussed include MLN-4924 (Millennium Pharmaceuticals Inc), GDC-0449 (Chugai Pharmaceutical Co Ltd/Curis Inc/F Hoffmann-La Roche Ltd/Genentech Inc/NCI), RDEA-119 (Ardea Biosciences Inc/Bayer HealthCare AG) and tafamidis (Fx-1006A; FoldRx Pharmaceuticals Inc).
authors.affiliation: Ensemble Discovery, Cambridge, MA 02139, USA. nterrett@ensemblediscovery.com
authors.forename: Nick
authors.initials: N
authors.lastname: Terrett
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D000686:Amyloidosis / Q000188:drug therapy; D000813:Anilides / Q000627:therapeutic use; D000818:Animals; D001583:Benzoxazoles / Q000737:chemistry / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical; D055808:Drug Discovery / Q000379:methods / Q000639:trends*; D064420:Drug-Related Side Effects and Adverse Reactions; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors; D006801:Humans; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy; D010599:Pharmacokinetics; D049268:Positron-Emission Tomography / Q000379:methods; D011725:Pyridines / Q000627:therapeutic use; D011789:Quantum Theory; D011971:Receptors, Immunologic / Q000037:antagonists & inhibitors; D011982:Receptors, Prostaglandin / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship
chemical_list: D000813:Anilides; D001583:Benzoxazoles; D004791:Enzyme Inhibitors; D018841:HSP90 Heat-Shock Proteins; C538724:HhAntag691; D047028:Macrocyclic Compounds; D011725:Pyridines; D011971:Receptors, Immunologic; D011982:Receptors, Prostaglandin; C547076:tafamidis; C036293:prostaglandin D2 receptor