title: [Paraneoplastic sclerodermiform syndrome].
abstract: BACKGROUND
  Despite the known association between scleroderma and cancer, the current systemic sclerosis classifications do not clearly identify paraneoplastic sclerodermiform syndrome or sclerodermiform syndrome secondary to cancer treatments.
  
  
  METHODS
  A 56 year old man was hospitalized for severe Raynaud's phenomenon with bilateral digital necrosis and otherwise good health status. X-rays did not show any subcutaneous calcification. Levels of serum antinuclear antibodies were high but anticentromere and anti-topoisomerase 1 antibodies were negative. Chest X-ray and CT-scan identified an irregular opacity in the right upper lobe with enlarged mediastinal lymph nodes. A diagnosis of bronchial adenocarcinoma was made following mediastinoscopy and the patient was treated with neo-adjuvant chemotherapy and lobectomy. After two cycles of treatment, his skin lesions had almost disappeared.
  
  
  CONCLUSIONS
  The presence of a sclerodermiform syndrome may suggest the existence of an underlying neoplasm. In this case report, the skin lesions disappeared quickly after antineoplastic treatment. We suggest that sclerodermiform syndrome be included in the systemic sclerosis classification.
authors.affiliation: Service de pneumologie et unité de soins intensifs respiratoires, université de Rouen, hôpital de Bois-Guillaume, CHU de Rouen, UPRES EA 3830 (IFR MP23), institut hospitalo-universitaire de recherche biomédicale, 76031 Rouen cedex, France. frederic.hounkpati@chu-rouen.fr
authors.forename: A
authors.initials: A
authors.lastname: Hounkpati
authors.forename: I
authors.initials: I
authors.lastname: Marie
authors.forename: D
authors.initials: D
authors.lastname: Paillotin
authors.forename: J-F
authors.initials: JF
authors.lastname: Muir
authors.forename: A
authors.initials: A
authors.lastname: Cuvelier
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000209:etiology*; D012595:Scleroderma, Systemic / Q000209:etiology*