A new paradigm for high-sensitivity 19F magnetic resonance imaging of perfluorooctylbromide.
In the present work, the NMR properties of perfluorooctylbromide are revisited to derive a high-sensitivity fluorine MRI strategy. It is shown that the harmful effects of J-coupling can be eliminated by carefully choosing the bandwidth of the 180 degrees pulses in a spin-echo sequence. The T(2) of the CF(3) resonance of the molecule is measured using a multispin-echo sequence and shown to dramatically depend on the interpulse delay. Following these observations, an optimized multispin-echo imaging sequence is derived and compared with short TE/pulse repetition time gradient echo and chemical shift imaging sequences. The unparalleled sensitivity yielded by the multispin-echo sequence is promising for future applications, in particular for targeted contrast agents such as perfluorooctylbromide nanoparticles.
Giraudeau
Céline
C
Neurospin, I2BM, Commissariat à l'Energie Atomique, Gif-sur-Yvette, France.
Flament
Julien
J
Marty
Benjamin
B
Boumezbeur
Fawzi
F
Mériaux
Sébastien
S
Robic
Caroline
C
Port
Marc
M
Tsapis
Nicolas
N
Fattal
Elias
E
Giacomini
Eric
E
Lethimonnier
Franck
F
Le Bihan
Denis
D
Valette
Julien
J
D003287:Contrast Media / Q000737:chemistry*; D005461:Fluorine; D005466:Fluorocarbons / Q000737:chemistry*; D006842:Hydrocarbons, Brominated; D007089:Image Enhancement / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D012680:Sensitivity and Specificity
D003287:Contrast Media; D005466:Fluorocarbons; D006842:Hydrocarbons, Brominated; D005461:Fluorine; C003072:perflubron