title: Validation of the International Criteria for Behçet's disease (ICBD) in Iran.
abstract: OBJECTIVE
  To evaluate the performance of the new International Criteria for Behçet's Disease (ICBD) in Iran. The ICBD was created in 2006 to replace the International Study Group (ISG) criteria (created in 1990). In this study, 14 existing diagnosis/classification criteria (Curth, Hewitt, Mason and Barnes, Japan original, Hubault and Hamza, O'Duffy, Cheng and Zhang, Dilsen, Japan revised, International Study Group, Iran traditional, Iran Classification Tree, revised Dilsen, Korea), were evaluated and compared to ICBD by calculating their sensitivity, specificity and accuracy.
  
  
  METHODS
  All patients from the Behçet's Disease registry (6128) and controls (3400), up to January 2008, entered the study. The diagnosis was clinical and not by any of the above-mentioned criteria. Sensitivity, specificity, accuracy (percent agreement), and 95% confidence interval were calculated. The performance of ICBD and ISG were compared by the McNemar test.
  
  
  RESULTS
  The sensitivity was 98.2% for ICBD and 78.1% for ISG (P < 0.0001). The specificity was 95.6% for ICBD and 98.4% for ISG (P < 0.0001). The accuracy was 97.3% for ICBD and 85.5% for ISG (P < 0.0001).
  
  
  CONCLUSIONS
  In Iranian patients, ICBD has 20.1% higher sensitivity and 11.8% higher accuracy than ISG, while the specificity was only 2.8% lower. ICBD was better optimized than ISG (difference between sensitivity and specificity 2.6% vs 20.3%).
  
  
  CONCLUSIONS
  ICBD has by far better performance than ISG in Iran. The difference is even more prominent in Iranian patients than in the cohort of the international patients upon whom the criteria were created.
authors.affiliation: Behçet's Unit, Rheumatology Research Center, Tehran University for Medical Sciences, Tehran 14114, Iran. fddh@davatchi.net
authors.forename: Fereydoun
authors.initials: F
authors.lastname: Davatchi
authors.forename: Bahar
authors.initials: B
authors.lastname: Sadeghi Abdollahi
authors.forename: Farhad
authors.initials: F
authors.lastname: Shahram
authors.forename: Abdolhadi
authors.initials: A
authors.lastname: Nadji
authors.forename: Cheyda
authors.initials: C
authors.lastname: Chams-Davatchi
authors.forename: Hormoz
authors.initials: H
authors.lastname: Shams
authors.forename: Nasim
authors.initials: N
authors.lastname: Naderi
authors.forename: Massoomeh
authors.initials: M
authors.lastname: Akhlaghi
authors.forename: Tahereh
authors.initials: T
authors.lastname: Faezi
authors.forename: Alireza
authors.initials: A
authors.lastname: Faridar
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D000368:Aged; D044466:Asian People; D001528:Behcet Syndrome / Q000150:complications / Q000175:diagnosis* / Q000208:ethnology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D007492:Iran / Q000453:epidemiology; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011237:Predictive Value of Tests; D012372:ROC Curve; D012042:Registries; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult