title: Impact of HIV infection, highly active antiretroviral therapy, and hepatitis C coinfection on serum interleukin-27.
abstract: A newly described cytokine, interleukin-27 (IL-27), that activates naive CD4 T cells, has recently been shown to be an anti-HIV cytokine. However, the effect of HIV infection on IL-27 expression has not been characterized. We found that clinical characteristics, including HIV viral load, hepatitis C virus coinfection, and CD4 T cell counts, were associated with changes in serum IL-27. Overall, our results suggest circulating HIV may suppress IL-27, a critical concept in treatment development with this cytokine.
authors.affiliation: Department of Microbiology and Immunology, Queen's University, Kingston, Ontario, Canada.
authors.forename: Christina
authors.initials: C
authors.lastname: Guzzo
authors.forename: Wilma M
authors.initials: WM
authors.lastname: Hopman
authors.forename: Nor Fazila
authors.initials: NF
authors.lastname: Che Mat
authors.forename: Wendy
authors.initials: W
authors.lastname: Wobeser
authors.forename: Katrina
authors.initials: K
authors.lastname: Gee
mesh_terms: D023241:Antiretroviral Therapy, Highly Active; D015496:CD4-Positive T-Lymphocytes; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy; D015497:HIV-1; D006526:Hepatitis C / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D019562:Viral Load
chemical_list: D020381:Interleukin-17