Formation and growth of lipofuscin in the retinal pigment epithelium cells.
The kinetics of lipofuscin growth in diseased retinal pigment epithelium cells is investigated using Monte Carlo simulations and scaling theory on a cluster aggregation model. The model captures the essential physics of lipofuscin growth in the cells. A remarkable feature is that small particles may be removed from the cells while the larger ones become fixed and grow by aggregation. Model simulations are compared to the number of lipofuscin granules in eyes with early age-related degeneration.
Mazzitello
K I
KI
Facultad de Ingeniería, Universidad Nacional de Mar del Plata, 7600 Mar del Plata, Argentina.
Arizmendi
C M
CM
Family
F
F
Grossniklaus
H E
HE
D002478:Cells, Cultured; D020256:Choroidal Neovascularization / Q000378:metabolism* / Q000473:pathology; D003198:Computer Simulation; D006801:Humans; D008062:Lipofuscin / Q000096:biosynthesis* / Q000138:chemical synthesis*; D008954:Models, Biological; D008956:Models, Chemical; D055213:Retinal Pigment Epithelium / Q000737:chemistry* / Q000378:metabolism* / Q000473:pathology
D008062:Lipofuscin