The influence of pk/pd on the structure of optimal controls in cancer chemotherapy models.
Mathematical models for cancer chemotherapy as optimal control problems are considered. Results on scheduling optimal therapies when the controls represent the effectiveness of chemotherapeutic agents, or, equivalently, when the simplifying assumption is made that drugs act instantaneously, are compared with more realistic models that include pharmacokinetic (PK) equations modelling the drug's plasma concentration and various pharmaco-dynamic (PD) models for the effect the concentrations have on cells.
Ledzewicz
Urszula
U
Department of Mathematics and Statistics, Southern Illinois University at Edwardsville, Edwardsville, IL, 62026. uledzew@siue.edu.
Schattler
Heinz
H