title: Oral and dental findings in a child with growth hormone insensitivity syndrome.
abstract: Growth hormone insensitivity syndrome, also known as Laron syndrome, is an autosomal recessive disorder caused by defects the of growth hormone receptor gene and may lead to increased growth hormone levels. This syndrome's main clinical features are: dwarfism; acromicria; organomicria; cervical spinal stenosis; early osteoarthritic changes of the atlantoaxial joint; small oropharynx; decreased growth velocity; insulin resistance; hypoglycemia; delayed skeletal maturation and osteoporosis; and muscular and central nervous tissue underdevelopment. The facial bones, especially sphenoid and mandibular, are also underdeveloped. No reports of the incidence of growth hormone insensitivity syndrome in the population are available in the literature. The purpose this case report was to describe oral findings and particularities of dental treatment in a child with growth hormone insensitivity syndrome.
authors.affiliation: Department of Pediatric Dentistry, Dental School, University of São Paulo-USP, São Paulo, Brazil. atjennyaa@usp.br
authors.forename: Jenny
authors.initials: J
authors.lastname: Abanto
authors.forename: Paula
authors.initials: P
authors.lastname: Celiberti
authors.forename: Fabiana Bucholdz Teixeira
authors.initials: FB
authors.lastname: Alves
authors.forename: Viviane
authors.initials: V
authors.lastname: Rossier
authors.forename: Stella Alves Campos
authors.initials: SA
authors.lastname: Vieira
authors.forename: Ana Lidia
authors.initials: AL
authors.lastname: Ciamponi
authors.forename: Daniela Prócida
authors.initials: DP
authors.lastname: Raggio
mesh_terms: D002648:Child; D006801:Humans; D046150:Laron Syndrome / Q000175:diagnosis*; D008297:Male; D009960:Oropharynx / Q000002:abnormalities*; D014071:Tooth Abnormalities / Q000175:diagnosis* / Q000628:therapy; D014076:Tooth Diseases / Q000175:diagnosis* / Q000628:therapy