Dietary glucoraphanin-rich broccoli sprout extracts protect against UV radiation-induced skin carcinogenesis in SKH-1 hairless mice.
Feeding broccoli sprout extracts providing daily doses of 10 micromol of glucoraphanin to SKH-1 hairless mice with prior chronic exposure to UV radiation (30 mJ cm(-2) of UVB, twice a week, for 17 weeks) inhibited the development of skin tumors during the subsequent 13 weeks; compared to the controls, tumor incidence, multiplicity, and volume were reduced by 25, 47, and 70%, respectively, in the animals that received the protective agent.
Dinkova-Kostova
Albena T
AT
The Lewis B. and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA. a.dinkovakostova@dundee.ac.uk
Fahey
Jed W
JW
Benedict
Andrea L
AL
Jenkins
Stephanie N
SN
Ye
Lingxiang
L
Wehage
Scott L
SL
Talalay
Paul
P
D000818:Animals; D001937:Brassica / Q000737:chemistry* / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000378:metabolism; D005260:Female; D005961:Glucosinolates / Q000378:metabolism*; D007096:Imidoesters / Q000378:metabolism*; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced / Q000473:pathology / Q000517:prevention & control*; D010091:Oximes; D010936:Plant Extracts / Q000494:pharmacology*; D012306:Risk; D012878:Skin Neoplasms / Q000473:pathology / Q000517:prevention & control*; D013454:Sulfoxides; D013997:Time Factors; D014466:Ultraviolet Rays / Q000009:adverse effects*
D004040:Dietary Carbohydrates; D005961:Glucosinolates; D007096:Imidoesters; D010091:Oximes; D010936:Plant Extracts; D013454:Sulfoxides; C119494:glucoraphanin