Exposing p120 catenin's most intimate affair.
p120-catenin regulates cell-cell adhesion by controlling cell surface retention of cadherin. In this issue, Ishiyama et al. (2010) present the first crystal structure of p120 in complex with cadherin, revealing molecular details of the functional interface and providing sophisticated new tools for dissecting p120's role in cell-cell adhesion.
Reynolds
Albert B
AB
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. al.reynolds@vanderbilt.edu