Influence of STAT4 polymorphism in primary Sjögren's syndrome.
OBJECTIVE
To examine the influence of STAT4 rs7574865 gene polymorphism on patients with primary Sjögren's syndrome (SS).


METHODS
Two different cohorts were studied: 69 patients with primary SS and 296 controls from Colombia and 108 patients with primary SS and 227 controls from Germany. Samples were genotyped for the STAT4 rs7574865 single-nucleotide polymorphism with a predesigned TaqMan single-nucleotide polymorphism genotyping assay. We carried out a metaanalysis of our results combined with data published to date.


RESULTS
Although no significant differences were observed in the allele frequencies of STAT4 rs7574865 gene polymorphism between patients and controls in Colombians (p = 0.28, OR 1.24, 95% CI 0.82-1.87) and Germans (p = 0.08, OR 1.40, 95% CI 0.96-2.02), the metaanalysis disclosed a significant effect of the T allele on disease (p = 4.7 x 10(-6), OR 1.40, 95% CI 1.21-1.62).


CONCLUSIONS
These data reinforce the influence of STAT4 gene on primary SS and as a general autoimmune gene.
Palomino-Morales
Rogelio J
RJ
Instituto de Parasitología y Biomedicina López-Neyra, Consejo Superior de Investigaciones Científicas, Granada, Spain. rpm@ipb.csic.es
Diaz-Gallo
Lina-Marcela
LM
Witte
Torsten
T
Anaya
Juan-Manuel
JM
Martín
Javier
J
D000328:Adult; D000483:Alleles; D015551:Autoimmunity / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D050797:STAT4 Transcription Factor / Q000235:genetics*; D012859:Sjogren's Syndrome / Q000235:genetics*
D050797:STAT4 Transcription Factor; C494090:STAT4 protein, human