title: Assessment of latent tuberculosis infection in Takayasu arteritis with tuberculin skin test and Quantiferon-TB Gold test.
abstract: A possible relationship between Takayasu arteritis (TA) and tuberculosis (TB) has been suggested. An increased frequency of tuberculin skin test (TST) was observed in TA patients. Quantiferon-TB Gold test (QFT) is a new in vitro assay measuring interferon-gamma response to M. tuberculosis antigens and helpful in diagnosing latent TB infection. The aim of this study was to investigate latent TB infection among TA patients by the use of both TST and QFT Gold test. Ninety-four (male/female: 7/87) TA patients fulfilling ACR 1990 TA criteria from three different university hospitals in Turkey and 107 control subjects without inflammatory diseases were included in the study. Data about medical history (TA and TB) were collected for both groups. TST and QFT were performed. TST values > or =5 mm for TA patients and > or =15 mm for controls was accepted as TST positivity. Even though TA group was older (40 +/- 12 vs. 32 +/- 8, P < 0.001), there was no significant difference between TA patients and controls regarding demographic characteristics. Six TA patients and one control had a history of previous TB infection (P = 0.054). Although TST positivity was higher in TA group [55 patients (62.5%) vs. 24 controls (41.4%), P = 0.008], QFT positivity was similar between two groups [21 patients (22.3%) vs. 24 controls (22.4%), P > 0.05]. QFT was negative in two of six TA patients with previous TB history. Rate of latent TB infection in TA patients measured with QFT is no more than controls. QFT seems to be a good and favorable test compared with TST in detecting LTBI in TA.
authors.affiliation: Faculty of Medicine, Department of Internal Medicine Unit of Rheumatology, Hacettepe University, Incesu Caddesi No: 72/2, Cankaya, Ankara, Turkey. omerk@hacettepe.edu.tr
authors.forename: Omer
authors.initials: O
authors.lastname: Karadag
authors.forename: Kenan
authors.initials: K
authors.lastname: Aksu
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Sahin
authors.forename: Figen Yargucu
authors.initials: FY
authors.lastname: Zihni
authors.forename: Burcin
authors.initials: B
authors.lastname: Sener
authors.forename: Nevsun
authors.initials: N
authors.lastname: Inanc
authors.forename: Umut
authors.initials: U
authors.lastname: Kalyoncu
authors.forename: Sibel Zehra
authors.initials: SZ
authors.lastname: Aydin
authors.forename: Sibel
authors.initials: S
authors.lastname: Ascioglu
authors.forename: Pinar Talu
authors.initials: PT
authors.lastname: Ocakci
authors.forename: Sule Apras
authors.initials: SA
authors.lastname: Bilgen
authors.forename: Gokhan
authors.initials: G
authors.lastname: Keser
authors.forename: Vedat
authors.initials: V
authors.lastname: Inal
authors.forename: Haner
authors.initials: H
authors.lastname: Direskeneli
authors.forename: Meral
authors.initials: M
authors.lastname: Calguneri
authors.forename: Ihsan
authors.initials: I
authors.lastname: Ertenli
authors.forename: Sedat
authors.initials: S
authors.lastname: Kiraz
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D005260:Female; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000097:blood; D055985:Latent Tuberculosis / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D011237:Predictive Value of Tests; D015995:Prevalence; D012680:Sensitivity and Specificity; D013625:Takayasu Arteritis / Q000150:complications* / Q000175:diagnosis*; D014374:Tuberculin Test / Q000379:methods* / Q000639:trends; D014421:Turkey; D055815:Young Adult
chemical_list: D007371:Interferon-gamma