Early detection of amyloid aggregation using intrinsic fluorescence.
Beta-amyloid (Abeta) aggregation, believed to be responsible for Alzheimer's disease, is monitored using its intrinsic fluorescence decay. Alterations in the fluorescence decay of tyrosine correlate with the Abeta aggregation at a much earlier stage than the traditionally used fluorescence intensity of Thioflavin T (ThT). Potentially the finding may underpin progress towards an earlier diagnosis of the onset of Alzheimer's disease and an improved approach to developing intervention therapies.
Rolinski
Olaf J
OJ
Photophysics Group, Centre for Molecular Nanometrology, Department of Physics, Scottish Universities Physics Alliance, University of Strathclyde, 107 Rottenrow, Glasgow G4 0NG, UK. o.j.rolinski@strath.ac.uk
Amaro
Mariana
M
Birch
David J S
DJ
D016229:Amyloid beta-Peptides / Q000032:analysis* / Q000737:chemistry*; D046912:Multiprotein Complexes / Q000032:analysis / Q000737:chemistry; D010446:Peptide Fragments / Q000032:analysis* / Q000737:chemistry*; D011485:Protein Binding; D025941:Protein Interaction Mapping / Q000379:methods*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D014443:Tyrosine / Q000737:chemistry*
D016229:Amyloid beta-Peptides; D046912:Multiprotein Complexes; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); D014443:Tyrosine