[Role of 125I seed implantation in treatment of unresectable pancreatic cancer].
OBJECTIVE
To study the role of (125)I seed implantation in the treatment of unresectable pancreatic cancer.


METHODS
From April 2004 to march 2006, 66 untreated patients with locally advanced pancreatic cancer (LAPC) were randomized into two groups: Group A: (125)I seeds implantation (n = 31) and Group B: control (n = 34). The objective tumor response, clinical benefit response, toxicity, complications and survival of two groups were observed.


RESULTS
In Group A, the overall response rate (PR + NC) was 80.6%. Clinical benefit response rate was 54.8%. No toxicity was observed. Gastrointestinal hemorrhage and pancreatic fistula occurred in 1 patient respectively in Group A. The survival rates of 6 and 12 months were 56.0% vs 31.4% and 16.8% vs 2.9% respectively in two groups (P < 0.05). The median survival time of two groups was 8.0 months vs 4.0 months (P < 0.05).


CONCLUSIONS
(125)I seed implantation is a simple, safe and effective method in the treatment of locally advanced pancreatic cancer.
Wang
Cheng-feng
CF
Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China.
Zhao
Ping
P
Li
Ye-xiong
YX
Shan
Yi
Y
Zhao
Dong-bing
DB
Tian
Yan-tao
YT
Sun
Yue-min
YM
Bai
Xiao-feng
XF
Che
Xu
X
Qu
Hui
H
Xie
Yi-bin
YB
Zheng
Rong
R
Zhou
Chun-wu
CW
D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000628:therapy; D011859:Radiography; D015996:Survival Rate; D016896:Treatment Outcome
D007457:Iodine Radioisotopes