title: Caripyrin, a new inhibitor of infection-related morphogenesis in the rice blast fungus Magnaporthe oryzae.
abstract: Caripyrin (trans-5-(3-methyloxiranyl)pyridincarboxylic acid methyl ester, 1), a new pyridyloxirane, was isolated from submerged cultures of the basidiomycete Caripia montagnei. The compound was found to inhibit conidial germination and appressorium formation in the rice blast fungus Magnaporthe oryzae, whereas the infection-related morphogenesis in several other phytopathogenic fungi was not affected. In plant assays on rice, 1 was found to protect plants more efficiently against fungal infection than the structurally related fungal secondary metabolite, fusaric acid. Contrary to the latter, 1 was neither cytotoxic, antibacterial, nor nematicidal.
authors.affiliation: Institute of Biotechnology and Drug Research (IBWF e.V.), Kaiserslautern, Germany.
authors.forename: Patrick H
authors.initials: PH
authors.lastname: Rieger
authors.forename: Johannes C
authors.initials: JC
authors.lastname: Liermann
authors.forename: Till
authors.initials: T
authors.lastname: Opatz
authors.forename: Heidrun
authors.initials: H
authors.lastname: Anke
authors.forename: Eckhard
authors.initials: E
authors.lastname: Thines
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001487:Basidiomycota / Q000378:metabolism*; D004852:Epoxy Compounds / Q000302:isolation & purification / Q000494:pharmacology*; D005285:Fermentation; D020082:Magnaporthe / Q000187:drug effects*; D009024:Morphogenesis / Q000187:drug effects; D012275:Oryza / Q000254:growth & development / Q000382:microbiology*; D010935:Plant Diseases / Q000517:prevention & control*; D011725:Pyridines / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D004852:Epoxy Compounds; D011725:Pyridines; C550681:trans-5-(3-methyloxiranyl)pyridincarboxylic acid methyl ester