title: Differences in prognostic factors according to viral status in patients with hepatocellular carcinoma.
abstract: The number and ratio of both HBsAg- and HCV Ab-negative hepatocellular carcinoma (HCC-nonBC) cases have been steadily increasing in Japan. The aim of this study was to examine the frequency of detection of HCC-nonBC by screening methods and to elucidate the clinical characteristics of HCC-nonBC compared with those of hepatitis C and/or B virus-associated HCC (HCC-virus). We recruited 624 patients with HCC who were diagnosed between 1982 and 2007 at the Department of Gastroenterology and Hepatology, Nagasaki University Hospital. They were categorized into 2 groups as follows: i) 550 were included in the HCC-virus group: positive for HBsAg and/or positive for HCV Ab, and ii) 74 were included in the HCC-nonBC group: negative for both HBsAg and HCV Ab. The follow-up patterns until the initial detection of HCC and the survival rates were analyzed and compared between the 2 groups. Multivariate analysis identified follow-up, alcohol consumption, albumin level, total bilirubin level, alpha-fetoprotein (AFP) level, and tumor-node-metastasis (TNM) stage as independent and significant risk factors for prognosis. Among the 397 patients with HCC in TNM stage I or II, multivariate analysis identified the cause of liver disease, gender, Child-Pugh score, serum albumin level and TNM stage as independent and significant risk factors for prognosis. We reported that the poor prognoses of patients with HCC-nonBC were attributable to its late detection in an advanced condition due to the absence of a surveillance system for the early detection of HCC. However, in early-stage patients, patients with HCC-nonBC showed significantly better prognosis than those in the HCC-virus group.
authors.affiliation: Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852-8501, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Akahoshi
authors.forename: Naota
authors.initials: N
authors.lastname: Taura
authors.forename: Tatsuki
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Hisamitsu
authors.initials: H
authors.lastname: Miyaaki
authors.forename: Motohisa
authors.initials: M
authors.lastname: Akiyama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Miuma
authors.forename: Eisuke
authors.initials: E
authors.lastname: Ozawa
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Takeshita
authors.forename: Toru
authors.initials: T
authors.lastname: Muraoka
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: Masashi
authors.initials: M
authors.lastname: Ohtani
authors.forename: Hajime
authors.initials: H
authors.lastname: Isomoto
authors.forename: Takehiro
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Fuminao
authors.initials: F
authors.lastname: Takeshima
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakao
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000401:mortality / Q000628:therapy / Q000821:virology*; D016009:Chi-Square Distribution; D055088:Early Detection of Cancer; D005260:Female; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology; D006509:Hepatitis B / Q000150:complications* / Q000175:diagnosis; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000276:immunology; D018937:Hepatitis C Antibodies / Q000097:blood; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000628:therapy / Q000821:virology*; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D012367:RNA, Viral / Q000097:blood; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies; D012367:RNA, Viral