Oocyte maturation failure: a syndrome of bad eggs.
To show that disruption of meiotic competence results in cell cycle arrest, and the production of immature oocytes that are not capable of fertilization. Through an extensive review of animal studies and clinical case reports, we define the syndrome of oocyte maturation failure as a distinct oocyte disorder, present a classification system based on clinical parameters, and discuss the potential molecular origins for the disease.
Beall
Stephanie
S
Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Brenner
Carol
C
Segars
James
J
D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods; D002454:Cell Differentiation / Q000502:physiology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000473:pathology*; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D009865:Oocytes / Q000166:cytology* / Q000502:physiology*; D009866:Oogenesis / Q000502:physiology; D027724:Reproductive Techniques, Assisted; D013577:Syndrome; D017211:Treatment Failure; D015053:Zygote / Q000166:cytology / Q000473:pathology*