title: Prospects for the development and use of gram-negative bacterial virulence protein secretion inhibitors for prophylaxis and treatment of infectious diseases.
abstract: As the breadth and number of bacterial pathogens exhibiting antibiotic resistance is rapidly increasing, our ability to treat new and re-emerging infectious diseases is being threatened. Therefore, the development of new therapeutic strategies, including drugs acting on new targets, is required. In this review, the feasibility of gram-negative bacterial secretion systems for the development of anti-virulence agents and possible arenas for their utility in therapeutic intervention of gram-negative bacterial infections such as gastroenteritis, nosocomial infections, and venereal diseases are discussed.
authors.affiliation: Department of Microbiology, University of Washington, Seattle, Washington 98195, USA. hrb@u.washington.edu.
authors.forename: Heather B
authors.initials: HB
authors.lastname: Felise
authors.forename: Samuel I
authors.initials: SI
authors.lastname: Miller
mesh_terms: D019072:Antibiotic Prophylaxis; D001426:Bacterial Proteins / Q000378:metabolism*; D003140:Communicable Disease Control; D003141:Communicable Diseases / Q000628:therapy*; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000472:pathogenicity*; D006801:Humans; D037521:Virulence Factors / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D037521:Virulence Factors