Oral and dental findings in a child with growth hormone insensitivity syndrome.
Growth hormone insensitivity syndrome, also known as Laron syndrome, is an autosomal recessive disorder caused by defects the of growth hormone receptor gene and may lead to increased growth hormone levels. This syndrome's main clinical features are: dwarfism; acromicria; organomicria; cervical spinal stenosis; early osteoarthritic changes of the atlantoaxial joint; small oropharynx; decreased growth velocity; insulin resistance; hypoglycemia; delayed skeletal maturation and osteoporosis; and muscular and central nervous tissue underdevelopment. The facial bones, especially sphenoid and mandibular, are also underdeveloped. No reports of the incidence of growth hormone insensitivity syndrome in the population are available in the literature. The purpose this case report was to describe oral findings and particularities of dental treatment in a child with growth hormone insensitivity syndrome.
Abanto
Jenny
J
Department of Pediatric Dentistry, Dental School, University of São Paulo-USP, São Paulo, Brazil. atjennyaa@usp.br
Celiberti
Paula
P
Alves
Fabiana Bucholdz Teixeira
FB
Rossier
Viviane
V
Vieira
Stella Alves Campos
SA
Ciamponi
Ana Lidia
AL
Raggio
Daniela Prócida
DP
D002648:Child; D006801:Humans; D046150:Laron Syndrome / Q000175:diagnosis*; D008297:Male; D009960:Oropharynx / Q000002:abnormalities*; D014071:Tooth Abnormalities / Q000175:diagnosis* / Q000628:therapy; D014076:Tooth Diseases / Q000175:diagnosis* / Q000628:therapy