title: Reduced bone density in individuals with severe hemophilia B.
abstract: OBJECTIVE
  The reduced bone density in individuals with severe hemophilia A (decreased coagulation factor VIII level) and combined factor V and VIII deficiency have been reported. In the current case-control study we tried to address bone mineral density in individuals with severe hemophilia B (decreased coagulation factor IX).
  
  
  METHODS
  In our case-control study, we recruited bone density and biochemical indexes in 14 individuals with severe hemophilia B and compared obtained results with 14 age- and sex-matched control group results.
  
  
  RESULTS
  Our results showed individuals with severe hemophilia B had reduced bone density in lumbar (-0.34 +/- 0.97) and femur (-0.82 +/- 1.37) regions, compared to the control group (0.84 +/- 0.53 and 1.02 +/- 1.04 respectively; P-value = 0.000 and 0.000).
  
  
  CONCLUSIONS
  The foremost complication of coagulation disorders are various types of excessive bleedings. The current study revealed severe hemophiliac B patients are prone to reduced bone density similar to severe hemophiliac A patients.
authors.affiliation: Immunology Research Center, Ghaem Hospital, Mashhad, Iran. Mansouritorghabe@mums.ac.ir
authors.forename: Hassan
authors.initials: H
authors.lastname: Mansouritorghabeh
authors.forename: Zahra
authors.initials: Z
authors.lastname: Rezaieyazdi
authors.forename: Nayyereh
authors.initials: N
authors.lastname: Saadati
authors.forename: Masoud
authors.initials: M
authors.lastname: Saghafi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Mirfeizi
authors.forename: Javad
authors.initials: J
authors.lastname: Rezai
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D015519:Bone Density; D016022:Case-Control Studies; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging; D006306:Health Surveys; D002836:Hemophilia B / Q000150:complications*; D006801:Humans; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000000981:diagnostic imaging* / Q000209:etiology*; D012720:Severity of Illness Index; D055815:Young Adult