title: [Corneal penetration of PAMAM dendrimers-coated puerarin liposomes].
abstract: OBJECTIVE
  To study the corneal penetration of PAMAM dendrimers-coated puerarin liposomes in rabbits.
  
  
  METHODS
  Evaluated PAMAM (G2, G3) dendrimers-coated puerarin liposomes were prepared and the in vitro transcorneal penetration were compared to puerarin drop solution and uncoated liposomes. The effect of different proportion of PAMAM to phospholipids in formulation on corneal penetration and the penetration parameters were investigated.
  
  
  RESULTS
  The steady state fluxes and permeability coefficients of puerarin by PAMAM G2 (1.0%) and PAMAM G3 (0.5%) coated puerarin liposomes were greater than that by puerarin drop solution and uncoated liposomess (P < 0.01), meanwhile the PAMAM G2 (1.0%) and PAMAM G3 (0.5%) coated liposomes were better than other ratios of coated liposomes for improvement of corneal penetration (P < 0.01).
  
  
  CONCLUSIONS
  The PAMAM coated liposomes is able to enhance the corneal penetration of puerarin and promising as an ocular drug carriers.
authors.affiliation: School of Pharmacy, Yantai University, Yantai 264005, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Kaoxiang
authors.initials: K
authors.lastname: Sun
authors.forename: Wenjun
authors.initials: W
authors.lastname: Yao
authors.forename: Na
authors.initials: N
authors.lastname: Liang
authors.forename: Hongjie
authors.initials: H
authors.lastname: Mu
authors.forename: Rongcai
authors.initials: R
authors.lastname: Liang
authors.forename: Chen
authors.initials: C
authors.lastname: Yao
mesh_terms: D000818:Animals; D003315:Cornea / Q000378:metabolism*; D050091:Dendrimers / Q000737:chemistry* / Q000378:metabolism*; D066298:In Vitro Techniques; D007529:Isoflavones / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry* / Q000378:metabolism*; D011817:Rabbits
chemical_list: D050091:Dendrimers; D007529:Isoflavones; D008081:Liposomes; C104700:PAMAM Starburst; C033607:puerarin