Hypolipidemic activity of Hibiscus rosa sinensis root in rats.
The hypolipidemic activity of Hibiscus rosa sinensis (family Malvaceae) root extract was studied on triton and cholesterol-rich high fat diet (HFD) induced models of hyperlipidemia in rats. In triton WR-1339-induced hyperlipidemia, feeding with root extract (500 mg/kg body wt/day p.o.) exerted lipid-lowering effect, as assessed by reversal of plasma levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG) and reactivation of post-heparin lipolytic activity (PHLA) of plasma. The other model was fed with cholesterol-rich HFD and root extract (500 mg/kg body wt/ day p.o.) simultaneously for 30 days. This also caused lowering of lipid levels in plasma and liver homogenate and reactivation of plasma PHLA and hepatic total lipoprotein lipase activity. The hypolipidemic activity of Hibiscus rosa sinensis root was compared with a standard drug guggulipid (200 mg/kg body wt/day p.o.), a known lipid- lowering agent in both models. Histopathological findings in rat liver supported the protective role of H. rosa sinensis root extract in preventing cholesterol-rich HFD-induced hepatic steatosis.
Kumar
Vishnu
V
Department of Biochemistry & Pathology, Era's Lucknow Medical College & Hospital, Lucknow, India.
Singh
Pradyumn
P
Chander
Ramesh
R
Mahdi
Farzana
F
Singh
Sushma
S
Singh
Ranjana
R
Khanna
Ashok Kumar
AK
Saxena
Jitendra Kumar
JK
Mahdi
Abbas Ali
AA
Singh
Vinod Kumar
VK
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004041:Dietary Fats / Q000009:adverse effects; D031584:Hibiscus / Q000737:chemistry*; D006949:Hyperlipidemias / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats
D004041:Dietary Fats; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D011092:Polyethylene Glycols; D002784:Cholesterol; C016811:tyloxapol