Serum uric acid, plasma glucose and diabetes.
The objective of this study was to investigate the association of serum UA with either FPG or 2hPG levels among Chinese adults in Qingdao, China. A population-based survey for diabetes was performed in 2006 in Qingdao. The survey included 1,490 men and 2,325 women aged 35-74 years who had data stored as required for the current data analysis. The association of mean UA with plasma glucose was tested using a linear regression model. Serum UA concentration raised with increasing FPG levels up to FPG of 7.0 mmol/l, but significantly decreased thereafter with further increase in FPG levels. The multivariate adjusted beta coefficient between FPG and UA in individuals with newly diagnosed diabetes was -0.20 for men and -0.27 for women (p<0.01 for both). A declining trend for the UA concentration was also observed at 2hPG of 10 mmol/l or higher in both genders. Fasting serum UA levels was higher in the pre-diabetic population but lower in people with diabetes than in normoglycaemic people. UA may serve as a potential biomarker of deterioration in glucose metabolism, but its clinical implication need to be further studied.
Hairong Nan
Department of Public Health, University of Helsinki, Helsinki, Finland. hairong.nan@helsinki.fi
Zengchang Pang
Shaojie Wang
Weiguo Gao
Lei Zhang
Jie Ren
Feng Ning
Tuomilehto
Jaakko
J
Qing Qiao
D000328:Adult; D000368:Aged; D044466:Asian People / Q000706:statistics & numerical data; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000175:diagnosis* / Q000208:ethnology; D005260:Female; D006306:Health Surveys; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011236:Prediabetic State / Q000097:blood* / Q000175:diagnosis* / Q000208:ethnology; D012424:Rural Population / Q000706:statistics & numerical data; D014505:Urban Population / Q000706:statistics & numerical data; D014527:Uric Acid / Q000097:blood*
D015415:Biomarkers; D001786:Blood Glucose; D014527:Uric Acid