title: Breast cancer cell survival signal is affected by bergapten combined with an ultraviolet irradiation.
abstract: In this study we have reported that bergapten (B) and bergapten plus UV (PUVA) are able to significantly affect MCF-7, ZR-75 and SKBR-3 breast cancer cell proliferations. B induced a lowering of PI3K/AKT survival signal in MCF-7 cells even in presence of IGF-I stimulation. Furthermore, B and in a higher extent, PUVA up-regulated the p53 mRNA and the protein content. An increased co-association between p21 WAF and proliferating cell nuclear antigen (PCNA) has been observed in PUVA-treated MCF-7 cells, thus inhibiting DNA replication. These results highlight how B, and its photoactivated compound, exert antiproliferative effects and induce apoptotic responses in breast cancer cells.
authors.affiliation: Department of Cellular Biology, University of Calabria, Cosenza, Italy. mamissina@yahoo.it
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Panno
authors.forename: Francesca
authors.initials: F
authors.lastname: Giordano
authors.forename: Fabrizia
authors.initials: F
authors.lastname: Mastroianni
authors.forename: M Grazia
authors.initials: MG
authors.lastname: Palma
authors.forename: Viviana
authors.initials: V
authors.lastname: Bartella
authors.forename: Amalia
authors.initials: A
authors.lastname: Carpino
authors.forename: Saveria
authors.initials: S
authors.lastname: Aquila
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Andò
mesh_terms: D000078223:5-Methoxypsoralen; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology; D008730:Methoxsalen / Q000031:analogs & derivatives* / Q000494:pharmacology; D017319:Photosensitizing Agents / Q000494:pharmacology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D011827:Radiation; D015398:Signal Transduction / Q000187:drug effects*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D017319:Photosensitizing Agents; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53; D000078223:5-Methoxypsoralen; D007334:Insulin-Like Growth Factor I; D051057:Proto-Oncogene Proteins c-akt; D008730:Methoxsalen