Hyperbaric oxygen treatment reduces mortality in acute iron intoxication in rats.
Acute iron intoxication is one of the leading causes of overdose morbidity and mortality in children. The toxicity of iron has been postulated to be related to free radical formation and subsequent lipid peroxidation. Hyperbaric oxygen treatment can result in a number of beneficial biochemical, cellular and physiological effects, and has recently been shown to induce cellular protection against ischaemia, and in some cases against free radical formation. In the current study, we aimed to investigate the effects of hyperbaric oxygen treatment on mortality in acute iron intoxication in rats. After iron administration, 57 animals were divided into two groups: a treatment group receiving hyperbaric oxygen treatment (n = 30) and a control group (n = 27), and followed for 48 hr for signs of severe intoxication. In the second part of the study, 21 animals were divided into a treatment group receiving hyperbaric oxygen treatment (n = 10) and a control group (n = 11), and markers of oxidative stress were evaluated. We showed a significant reduction in mortality in hyperbaric oxygen-treated animals from 17 of 27 (62.9%) among untreated rats to 6 of 30 (20%). Surprisingly, in the treatment group, levels of oxidative stress markers were higher. We postulate that hyperbaric oxygen has a potentially beneficial effect in acute iron intoxication.
Youngster
Ilan
I
Clinical Pharmacology and Toxicology Unit, Assaf Harofeh Medical Center, Zerifin, Israel. ilanyoungster@yahoo.com
Abu-Kishk
Ibrahim
I
Kozer
Eran
E
Braunstein
Rony
R
Bar-Haim
Adina
A
Berkovitch
Matitiahu
M
D000818:Animals; D006931:Hyperbaric Oxygenation; D007501:Iron / Q000506:poisoning*; D008297:Male; D011041:Poisoning / Q000401:mortality / Q000628:therapy; D051381:Rats; D017208:Rats, Wistar; D023382:Toxicity Tests, Acute
D007501:Iron