Telemetry in a motion-sickness model implicates the abdominal vagus in motion-induced gastric dysrhythmia.
In humans, motion sickness is associated with disruption of normal gastric myoelectric activity, and it has been proposed that this results from an imbalance of autonomic nervous system activity. We used the established Suncus murinus (house musk shrew) model of motion-induced emesis to investigate the effect of horizontal motion on gastric myoelectric activity (recorded using telemetry) and the involvement of the abdominal vagi. Surgical vagotomy increased baseline dysrhythmia and reduced the dominant power of the gastric myoelectric signals. In response to motion, normal gastric myoelectric activity was reduced in sham-operated animals but not in vagotomized animals. Vagotomy, however, failed to affect motion-induced emesis. In conclusion, motion had a differential effect in sham-operated and vagotomized animals, which is consistent with the hypothesis that motion-induced dysrhythmia arises from an autonomic nervous system imbalance.
Percie du Sert
Nathalie
N
University of London, UK. npercied@sgul.ac.uk
Chu
Kit M
KM
Wai
Man K
MK
Rudd
John A
JA
Andrews
Paul L R
PL
D000818:Animals; D001341:Autonomic Nervous System / Q000502:physiology; D008297:Male; D008564:Membrane Potentials / Q000502:physiology; D009041:Motion Sickness / Q000503:physiopathology*; D012788:Shrews; D013270:Stomach / Q000502:physiology; D013686:Telemetry; D014630:Vagus Nerve / Q000502:physiology*; D014839:Vomiting / Q000209:etiology