title: TYMS, MTHFR, p53 and MDR1 gene polymorphisms in breast cancer patients treated with adjuvant therapy.
abstract: OBJECTIVE
  The distribution of TSER (TYMS), C677T (MTHFR), Arg72Pro (p53) and C3435T (MDR1) gene polymorphisms was investigated in 80 consecutive breast cancer patients treated with adjuvant chemotherapy.
  
  
  RESULTS
  Observed allelic frequencies were: TSER, (2) 0.55 and (3) 0.45; MTHFR C677T, (C) 0.65 and (T) 0.35; p53 Arg72Pro, (Arg) 0.76 and (Pro) 0.24; MDR1 C3435T, (C) 0.51 and (T) 0.49. MTHFR C677T was found to be a strong predictor of the presence of multifocal tumour (odds ratio, 4.1; 95% CI, 1.1-15.7; P=0.035).
  
  
  CONCLUSIONS
  Our data indicate that breast cancer patients with the C/C variant may present multifocal tumour most frequently.
authors.affiliation: Clinical Science Department, Universidad de Las Palmas de Gran Canaria, Spain. lhenriquez@dcc.ulpgc.es
authors.forename: Luis Alberto
authors.initials: LA
authors.lastname: Henríquez-Hernández
authors.forename: Leandro Fernández
authors.initials: LF
authors.lastname: Pérez
authors.forename: Ana González
authors.initials: AG
authors.lastname: Hernández
authors.forename: Antonio Cabrera
authors.initials: AC
authors.lastname: de León
authors.forename: Bonifacio
authors.initials: B
authors.lastname: Díaz-Chico
authors.forename: A Murias
authors.initials: AM
authors.lastname: Rosales
mesh_terms: D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D018275:Carcinoma, Lobular / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D005260:Female; D005838:Genotype; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D013940:Thymidylate Synthase / Q000235:genetics*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics*
chemical_list: C513055:ABCB1 protein, human; D018435:ATP Binding Cassette Transporter, Subfamily B; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D013940:Thymidylate Synthase