Novel benzimidazole-pyrimidine conjugates as potent antitumor agents.
As a continuation to our previous work in synthesizing antitumor benzimidazoles, a series of 2-((1H-benzo[d]imidazol-2-yl)methylthio)-4-(substituted)-6-phenylpyrimidine-5-carbonitriles was synthesized. Evaluation of the synthesized compounds for their in vitro cytotoxic activity against twelve cell lines namely, Cervical carcinoma (KB), Ovarial carcinoma (SK OV-3), CNS cancer (SF-268), Non small lung cancer (NCI H460), Colonadenocarcinoma (RKOP27), Leukaemia (HL60, U937, K562), Melanoma (G361, SK-MEL-28) and Neuroblastoma (GOTO, NB-1) revealed their marked potency when compared with known anticancer drugs.
Abdel-Mohsen
Heba T
HT
Department of Chemistry of Natural and Microbial Products, Division of Pharmaceutical and Drug Industries Research, National Research Centre, Cairo, Egypt.
Ragab
Fatma A F
FA
Ramla
Mostafa M
MM
El Diwani
Hoda I
HI
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001562:Benzimidazoles / Q000737:chemistry*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D007928:Lethal Dose 50; D011743:Pyrimidines / Q000737:chemistry*
D000970:Antineoplastic Agents; D001562:Benzimidazoles; D011743:Pyrimidines; C031000:benzimidazole; C030986:pyrimidine