Conjugated polyelectrolyte capsules: light-activated antimicrobial micro "Roach Motels".
Microcapsules consisting of alternating layers of oppositely charged poly(phenylene ethynylene)-type conjugated polyelectrolytes (CPEs) were prepared via layer-by-layer deposition onto MnCO3 template particles followed by dissolution of the template particles using an ethylenediaminetetraacetate solution. The resulting microcapsules exhibit bright-green fluorescence emission characteristics of the CPEs. Strong antimicrobial activity was observed upon mixing of polyelectrolyte capsules with Cobetia marina or Pseudomonas aeruginosa followed by white-light irradiation. It was demonstrated that the materials act as highly effective light-activated micro "Roach Motels" with greater than 95% kill after exposure to approximately 1 h of white light.
Corbitt
Thomas S
TS
Sommer
Jonathan R
JR
Chemburu
Sireesha
S
Ogawa
Katsu
K
Ista
Linnea K
LK
Lopez
Gabriel P
GP
Whitten
David G
DG
Schanze
Kirk S
KS
D000480:Alkynes / Q000737:chemistry; D004202:Disinfectants / Q000737:chemistry* / Q000494:pharmacology / Q000528:radiation effects; D004573:Electrolytes / Q000737:chemistry; D004987:Ethers / Q000737:chemistry; D018613:Microscopy, Confocal; D008856:Microscopy, Fluorescence; D055616:Microtechnology / Q000379:methods*; D044130:Oceanospirillaceae / Q000187:drug effects; D055668:Photochemical Processes; D011108:Polymers / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects
D000480:Alkynes; D004202:Disinfectants; D004573:Electrolytes; D004987:Ethers; D011108:Polymers; C436384:phenyleneethynylene