title: Emulsification of coenzyme Q10 using gum arabic increases bioavailability in rats and human and improves food-processing suitability.
abstract: We evaluated the characteristics of a coenzyme Q(10) (CoQ(10)) formulation created with gum arabic. We defined the formulation's "modulus of inclusion," a reference index of the emulsified state, as the CoQ(10) not extracted by hexane as a percentage of the total CoQ(10) content of the formulation. The emulsified CoQ(10) formulation had a smaller particle size and larger modulus of inclusion value than the equivalent unemulsified formulation. In a kinetic study in rats, serum CoQ(10) levels were significantly greater with the emulsified CoQ(10) formulation than with the equivalent unemulsified formulation, which barely increased the levels. In a human study, oral intake of the emulsified formulation significantly increased plasma CoQ(10) levels, which peaked 6 h after intake, compared with the equivalent unemulsified formulation or CoQ(10) bulk powder. There was a significant positive correlation between baseline plasma CoQ(10) and total cholesterol levels, but no correlation was observed between absorption of CoQ(10) and baseline CoQ(10) levels. The emulsified CoQ(10) formulation was highly stable against heat and high humidity and in the presence of some materials (magnesium oxide, vitamin C, and vitamin E). In conclusion, emulsification of CoQ(10) using gum arabic increased bioavailability in both rats and humans and improved suitability for food processing.
authors.affiliation: Healthcare Product Development Center, Kyowa Hakko Bio Co., Ltd., Ibaraki, Japan.
authors.forename: Aya
authors.initials: A
authors.lastname: Ozaki
authors.forename: Ayako
authors.initials: A
authors.lastname: Muromachi
authors.forename: Mika
authors.initials: M
authors.lastname: Sumi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sakai
authors.forename: Koji
authors.initials: K
authors.lastname: Morishita
authors.forename: Tadashi
authors.initials: T
authors.lastname: Okamoto
mesh_terms: D000328:Adult; D000818:Animals; D001682:Biological Availability; D002784:Cholesterol / Q000097:blood; D019587:Dietary Supplements; D004355:Drug Stability; D045703:Emulsifying Agents; D004655:Emulsions; D005511:Food Handling; D006170:Gum Arabic; D006801:Humans; D008297:Male; D010316:Particle Size; D011208:Powders; D051381:Rats; D017207:Rats, Sprague-Dawley; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics; D055815:Young Adult
chemical_list: D045703:Emulsifying Agents; D004655:Emulsions; D011208:Powders; D014451:Ubiquinone; D006170:Gum Arabic; D002784:Cholesterol; C024989:coenzyme Q10