Has innate immunity evolved through different routes?
Invertebrate self/non-self recognition, defense responses, mating and development share innate immune surveillance and functions challenged by competition and linked to fitness. Independent evolutionary branches of immune responses may use conserved gene traits. On the other hand immunity genes may be conserved due to their role in development. Finally, upregulation of innate immunity genes during ascidian metamorphosis supports the danger hypothesis.
Parrinello
Nicolò
N
Dipartimento di Biologia Animale, Università di Palermo, Via Archirafi 18, 9123 Palermo, Italy. nicpar@unipa.it
D000818:Animals; D005075:Biological Evolution; D016207:Cytokines / Q000276:immunology; D007113:Immunity, Innate / Q000276:immunology*; D007448:Invertebrates / Q000235:genetics / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000235:genetics; D018448:Models, Immunological
D016207:Cytokines