Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis.
In recent years, a number of gene clusters involved in the biosynthesis of polyketide compounds have been characterized and the genes have been used for designing and developing novel chemical entities by combinatorial biosynthesis. This review covers the highlights of combinatorial biosynthesis using polyketide-modifying enzymes such as oxidoreductases, group transferases, halogenases, cyclases and deoxysugar biosynthesis enzymes, focusing on those from actinomycetes (with 315 references cited).
Olano
Carlos
C
Departamento de Biología Funcional, Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, 33006, Oviedo, Spain.
Méndez
Carmen
C
Salas
José A
JA
D039903:Actinobacteria / Q000737:chemistry*; D001688:Biological Products; D020650:Combinatorial Chemistry Techniques; D018942:Macrolides; D015394:Molecular Structure; D048630:Polyketide Synthases / Q000378:metabolism*
D001688:Biological Products; D018942:Macrolides; D048630:Polyketide Synthases