title: Pediatric abdominal masses: diagnostic accuracy of diffusion weighted MRI.
abstract: OBJECTIVE
  To retrospectively identify apparent diffusion coefficient (ADC) values of pediatric abdominal mass lesions, to determine whether measured ADC of the lesions and signal intensity on diffusion-weighted (DW) images allow discrimination between benign and malignant mass lesions.
  
  
  METHODS
  Approval for this retrospective study was obtained from the institutional review board. Children with abdominal mass lesions, who were examined by DW magnetic resonance imaging (MRI) were included in this study. DW MR images were obtained in the axial plane by using a non breath-hold single-shot spin-echo sequence on a 1.5-T MR scanner. ADCs were calculated for each lesion. ADC values were compared with Mann-Whitney U test. Receiver operating characteristic curve analysis was performed to determine cut-off values for ADC. The results of visual assessment on b800 images and ADC map images were compared with chi-square test.
  
  
  RESULTS
  Thirty-one abdominal mass lesions (16 benign, 15 malignant) in 26 patients (15 girls, 11 boys, ranging from 2 days to 17 years with 6.9 years mean) underwent MRI. Benign lesions had significantly higher ADC values than malignant ones (P < .001). The mean ADCs of malignant lesions were 0.84 +/- 1.7x10(-3) mm2/s, while the mean ADCs of the benign ones were 2.28 +/- 1.00x10(-3) mm2/s. With respect to cutoff values of ADC: 1.11x10(-3) mm2/s, sensitivity and negative predictive values were 100%, specificity was 78.6% and positive predictive value was 83.3%. For b800 and ADC map images, there were statistically significant differences on visual assessment. All malignant lesions had variable degrees of high signal intensity whereas eight of the 16 benign ones had low signal intensities on b800 images (P < .001). On ADC map images, all malignant lesions were hypointense and most of the benign ones (n=11, 68.7%) were hyperintense (P < .001).
  
  
  CONCLUSIONS
  DW imaging can be used for reliable discrimination of benign and malignant pediatric abdominal mass lesions based on considerable differences in the ADC values and signal intensity changes.
authors.affiliation: Department of Radiology, Gulhane Military Medical School, Ankara, Turkey. kocaoglumurat@yahoo.com
authors.forename: Murat
authors.initials: M
authors.lastname: Kocaoglu
authors.forename: Nail
authors.initials: N
authors.lastname: Bulakbasi
authors.forename: Hatice T
authors.initials: HT
authors.lastname: Sanal
authors.forename: Erol
authors.initials: E
authors.lastname: Kismet
authors.forename: Bahadir
authors.initials: B
authors.lastname: Caliskan
authors.forename: Veysel
authors.initials: V
authors.lastname: Akgun
authors.forename: Cem
authors.initials: C
authors.lastname: Tayfun
mesh_terms: D000008:Abdominal Neoplasms / Q000175:diagnosis*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult