title: D225G mutation in the hemagglutinin protein found in 3 severe cases of 2009 pandemic influenza A (H1N1) in Spain.
abstract: From 27 April to 16 December 2009, we analyzed the hemagglutinin gene sequence of 2009 pandemic influenza A (H1N1) virus in 189 respiratory specimens. We only found the D225G mutation in 3 severe cases. However, it was not found in samples from other cases with or without clinical criteria of severity. The biologic significance of this mutation remains still unclear.
authors.affiliation: Microbiology Laboratory, Hospital Clínic, 08036 Barcelona, Spain. aanton76@gmail.com
authors.forename: Andrés
authors.initials: A
authors.lastname: Antón
authors.forename: María Angeles
authors.initials: MA
authors.lastname: Marcos
authors.forename: Miguel Julián
authors.initials: MJ
authors.lastname: Martínez
authors.forename: Susana
authors.initials: S
authors.lastname: Ramón
authors.forename: Anna
authors.initials: A
authors.lastname: Martínez
authors.forename: Neus
authors.initials: N
authors.lastname: Cardeñosa
authors.forename: Pere
authors.initials: P
authors.lastname: Godoy
authors.forename: Nuria
authors.initials: N
authors.lastname: Torner
authors.forename: Patricia
authors.initials: P
authors.lastname: De Molina
authors.forename: Ricard
authors.initials: R
authors.lastname: Isanta
authors.forename: María Teresa
authors.initials: MT
authors.lastname: Jiménez de Anta
authors.forename: Tomàs
authors.initials: T
authors.lastname: Pumarola
mesh_terms: D006389:Hemagglutinins, Viral / Q000235:genetics* / Q000302:isolation & purification; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics* / Q000302:isolation & purification; D007251:Influenza, Human / Q000821:virology*; D020125:Mutation, Missense; D017354:Point Mutation; D017422:Sequence Analysis, DNA; D013030:Spain
chemical_list: D006389:Hemagglutinins, Viral; C458881:hemagglutinin fusogenic peptide, influenza virus