title: Daily practice of mechanical ventilation in Italian pediatric intensive care units: a prospective survey.
abstract: OBJECTIVE
  To assess how children requiring endotracheal intubation are mechanically ventilated in Italian pediatric intensive care units (PICUs).
  
  
  METHODS
  A prospective, national, observational, multicenter, 6-month study.
  
  
  METHODS
  Eighteen medical-surgical PICUs.
  
  
  METHODS
  A total of 1943 consecutive children, aged 0-16 yrs, admitted between November 1, 2006 and April 30, 2007.
  
  
  METHODS
  None.
  
  
  RESULTS
  Data on cause of respiratory failure, length of mechanical ventilation (MV), mode of ventilation, use of specific interventions were recorded for all children requiring endotracheal intubation for >24 hrs. Children were stratified for age, type of patient, and cause of respiratory failure. A total of 956 (49.2%) patients required MV via an endotracheal tube; 673 (34.6%) were ventilated for >24 hrs. The median length of MV was 4.5 days for all patients. If postoperative patients were excluded, the median time was 5 days. Bronchiolitis (6.7%), pneumonia (6.7%), and upper airway obstruction (5.3%) were the most frequent causes of acute respiratory failure, and altered mental status (9.2%) was the most frequent reason for MV. The overall mortality was 6.7% with highest rates for heart disease (nonoperative), sepsis, and acute respiratory distress syndrome (26.1%, 22.2%, and 16.7% respectively). Length of stay, associated chronic disease, severity score on admission, and PICU mortality were significantly higher in children who received MV (p < .05) than in children who did not. Controlled MV and pressure support ventilation + synchronized intermittent mandatory ventilation were the most frequently used modes of ventilatory assistance during PICU stay.
  
  
  CONCLUSIONS
  Mechanical ventilation is frequently used in Italian PICUs with almost one child of two requiring endotracheal intubation. Children treated with MV represent a more severe category of patients than children who are breathing spontaneously. Describing the standard care and how MV is performed in children can be useful for future clinical studies.
authors.affiliation: Department of Anesthesia and Intensive Care, Children's Hospital V Buzzi, Milan, Italy. andrea.wolfler@icp.mi.it
authors.forename: Andrea
authors.initials: A
authors.lastname: Wolfler
authors.forename: Edoardo
authors.initials: E
authors.lastname: Calderoni
authors.forename: Giancarlo
authors.initials: G
authors.lastname: Ottonello
authors.forename: Giorgio
authors.initials: G
authors.lastname: Conti
authors.forename: Simonetta
authors.initials: S
authors.lastname: Baroncini
authors.forename: Pierantonio
authors.initials: P
authors.lastname: Santuz
authors.forename: Pasquale
authors.initials: P
authors.lastname: Vitale
authors.forename: Ida
authors.initials: I
authors.lastname: Salvo
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002985:Clinical Protocols; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric; D007442:Intubation, Intratracheal / Q000706:statistics & numerical data; D007558:Italy; D008297:Male; D011446:Prospective Studies; D012121:Respiration, Artificial / Q000379:methods* / Q000706:statistics & numerical data; D012131:Respiratory Insufficiency / Q000628:therapy