Prospects for new antimicrobials based on N,N-dimethylbiguanide complexes as effective agents on both planktonic and adhered microbial strains.
Metal-free N,N-dimethylbiguanidium acetate and novel complexes M(DMBG)(2)(CH(3)COO)(2).nH(2)O (M: Mn(II), Ni(II), Cu(II) and Zn(II)) were screened for their antimicrobial properties against Gram-positive (Bacillus subtilis, Listeria monocytogenes, Staphylococcus aureus), Gram-negative (Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa) bacteria and fungal (Candida albicans) strains. The ability of compounds to inhibit the microbial adherence ability to the inert substratum as well as their cytotoxicity was also assessed. Our results are demonstrating that some of the tested compounds are exhibiting potent antimicrobial activity accompanied by low cytotoxicity on HeLa cells. The complexes were characterized using microanalytical, IR, EPR, (1)H NMR as well as UV-vis methods. The redox behaviour of complexes was investigated by cyclic voltammetry. The new derivative (HDMBG)(CH(3)COO) crystallizes in the monoclinic P2(1)/n space group as X-ray single-crystal data indicate.
Olar
Rodica
R
Department of Inorganic Chemistry, University of Bucharest, 90-92 Panduri St., 050663 Bucharest, Romania. rodica_m_olar@yahoo.com
Badea
Mihaela
M
Marinescu
Dana
D
Chifiriuc
Carmen-Mariana
CM
Bleotu
Coralia
C
Grecu
Maria Nicoleta
MN
Iorgulescu
Emilia Elena
EE
Bucur
Marcela
M
Lazar
Veronica
V
Finaru
Adriana
A
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001422:Bacterial Adhesion / Q000187:drug effects*; D018441:Biofilms / Q000187:drug effects; D018360:Crystallography, X-Ray; D004563:Electrochemistry; D005658:Fungi / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D008280:Magnetics; D008687:Metformin / Q000737:chemistry* / Q000494:pharmacology*; D010084:Oxidation-Reduction; D010933:Plankton / Q000187:drug effects*; D013057:Spectrum Analysis
D000890:Anti-Infective Agents; D008687:Metformin