title: Effects of alpha-DT cement with hydroxypropyl cellulose on bone augmentation within a titanium cap in the rabbit calvarium.
abstract: The present study was performed to evaluate the effects of calcium phosphate cement (alpha-DT cement) containing alpha-TCP, dicalcium phosphate anhydrous, and tetracalcium phosphate mixed with hydroxypropyl cellulose (HPC) for bone augmentation within a titanium cap in the rabbit calvarium. A total of 24 male adult Japanese white rabbits were used in this study. In each rabbit, one side of the cap was filled with alpha-DT cement (alpha-DT) or alpha-DT cement mixed with HPC (alpha-DTH), and the other side of the cap was left empty (control). After 1 and 3 months, newly generated tissue and mineralized bone areas were measured histomorphometrically. Significant differences in newly generated tissue and mineralized tissue were observed between the alpha-DT or alpha-DTH group and the control at 3 months. Furthermore, alpha-DTH showed significantly more mineralized tissue than alpha-DT group. Our findings indicated that although alpha-DT cement was effective for bone augmentation, alpha-DTH was more useful than alpha-DT for bone maturation.
authors.affiliation: Division of Applied Oral Sciences, Nihon University Graduate School of Dentistry, Chiyoda-ku, Tokyo, Japan.
authors.forename: Tomihisa
authors.initials: T
authors.lastname: Fukuyama
authors.forename: Shuichi
authors.initials: S
authors.lastname: Sato
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Fukase
authors.forename: Koichi
authors.initials: K
authors.lastname: Ito
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D001843:Bone Cements / Q000627:therapeutic use*; D001847:Bone Diseases / Q000473:pathology / Q000601:surgery*; D001861:Bone Regeneration / Q000187:drug effects*; D002113:Calcification, Physiologic / Q000187:drug effects; D002130:Calcium Phosphates / Q000627:therapeutic use*; D002482:Cellulose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D048091:Guided Tissue Regeneration / Q000295:instrumentation*; D006253:Haversian System / Q000473:pathology; D007091:Image Processing, Computer-Assisted; D008297:Male; D008422:Materials Testing; D010006:Osteoblasts / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D011817:Rabbits; D012886:Skull / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D014025:Titanium
chemical_list: D001843:Bone Cements; D002130:Calcium Phosphates; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D002482:Cellulose; C008079:hydroxypropylcellulose; D014025:Titanium; C485829:calcium phosphate, dibasic, anhydrous