Multicomponent reactions of amines with aldehydes and H(2)S as efficient route to heterocycles and thioaza macrocycles.
Here we provide new experimental results on multicomponent reactions of amines with aldehydes and H(2)S in the directed synthesis of functionally-substituted 1,3-thiazetidines, 1,3,5-dithiazinanes, 1,3,5-thiadiazinanes, 1,5-dithia-3,7-diazacyclooctanes, and thioaza macrocycles. X-ray analysis gave insight into the structure of the synthesized compounds. New kinds of multicomponent reactions (MCR) have been discovered and characterized.
Akhmetova
V R
VR
Institute of Petrochemistry and Catalysis of Russian Academy of Sciences, Prospekt Oktyabrya, 141, Ufa 450075, Russia. ink@anrb.ru
Khabibullina
G R
GR
Rakhimova
E B
EB
Vagapov
R A
RA
Khairullina
R R
RR
Niatshina
Z T
ZT
Murzakova
N N
NN
D000447:Aldehydes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D001372:Aza Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D018360:Crystallography, X-Ray; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006834:Hydrazines / Q000737:chemistry; D006862:Hydrogen Sulfide / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry; D013696:Temperature
D000447:Aldehydes; D000588:Amines; D001372:Aza Compounds; D006571:Heterocyclic Compounds; D006834:Hydrazines; D047028:Macrocyclic Compounds; D010636:Phenols; D006862:Hydrogen Sulfide