[Effect of oral contraceptive pills upon IVF outcomes of patients under a short GnRH agonist protocol].
OBJECTIVE
To determine the link between oral contraceptive pill (OCP) use and IVF/ICSI treatment outcomes under a short GnRH agonist protocol.


METHODS
A total of 186 patients (one cycle each patient) received a short GnRH agonist protocol at Day 2 of menstrual cycle for IVF/ICSI. Among them, 83 patients took OCP pre-treatment prior to the stimulation protocol (OCP group) and 103 patients received no OCP (non-OCP group). The triggering of final oocyte maturation was performed with 10 000 IU of hCG.


RESULTS
The ongoing pregnancy rates per started cycle in the non-OCP group and OCP group were 27.8% and 12.7% (P < 0.05) respectively. The clinical pregnancy rate and embryo implantation rate were significantly reduced in OCP group (clinical pregnancy rate 16.5%, implantation rate 11.2%) as compared with non-OCP group (32.2% and 19.9%, P < 0.05). The endometrium on hCG day was thicker in non-OCP group than OCP group (9.5 mm vs 8.7 mm, P < 0.05).


CONCLUSIONS
Pretreatment with OCP, as compared with initiation of stimulation at Day 2 of cycle in patients treated with GnRH-a short protocol antagonist appears to be associated with a significant difference in ongoing pregnancy rates per started cycle.
Tian
Li
L
Department of Obstetrics & Gynecology, Peking University People's Hospital, Beijing 100044, China.
Wu
Dan
D
Shen
Huan
H
Wei
Li-hui
LH
D000328:Adult; D003276:Contraceptives, Oral / Q000494:pharmacology*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy; D018873:Pregnancy Rate
D003276:Contraceptives, Oral; D007987:Gonadotropin-Releasing Hormone