Soft skills turned into hard facts: nucleosome remodelling at developmental switches.
Nucleosome remodelling factors are regulators of DNA accessibility in chromatin and lubricators of all major functions of eukaryotic genomes. Their action is transient and reversible, yet can be decisive for irreversible cell-fate decisions during development. In addition to the well-known local actions of nucleosome remodelling factors during transcription initiation, more global and fundamental roles for remodelling complexes in shaping the epigenome during development are emerging.
Chioda
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M
Adolf-Butenandt-Institute and Center for Integrated Protein Science (CiPSM), Ludwig-Maximilians-University, Munich, Germany.
Becker
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PB
D000818:Animals; D042002:Chromatin Assembly and Disassembly; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D009707:Nucleosomes / Q000235:genetics* / Q000378:metabolism*
D009707:Nucleosomes