Factors associated with failure to achieve birth emphasizing a successful singleton at term following in vitro fertilization.
OBJECTIVE
To evaluate the factors that might affect birth emphasizing a successful singleton at term (BESST) outcomes in women undergoing in vitro fertilization.


METHODS
A retrospective review of assisted reproduction cases from January 1, 2001, to July 31, 2005, at the Far Eastern Memorial Hospital, Taipei, Taiwan. Variables that were potentially associated with failure to achieve BESST were evaluated using univariate and multivariate logistic regression analysis.


RESULTS
Successful embryo transfer occurred in 297 of the 323 cases of assisted reproduction. In total, 123 women became pregnant and were enrolled for analysis, of whom 94 had live births and 55 achieved BESST. Multivariate analysis indicated that the number of embryos transferred, the presence of ovarian hyperstimulation syndrome, female infertility factors (other than tubal factors), and embryo quality were associated with increased relative risk of BESST failure, with odds ratios of 1.02 (95% confidence interval [CI], 1.01-1.02), 1.21 (95% CI, 1.08-1.36), 1.41 (95% CI, 1.22-1.62), and 0.79 (95% CI, 0.68-0.91), respectively.


CONCLUSIONS
The number of embryos transferred, the presence of ovarian hyperstimulation syndrome, female infertility factors other than tubal factors, and embryo quality correlate with the risk of failure to achieve BESST.
Lien
Yih-Ron
YR
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Taipei, Taiwan.
Lu
Hsin-Fen
HF
Peng
Fu-Shiang
FS
Chiu
Bao-Chu
BC
Yeh
Szu-Hsing
SH
Yang
Yu-Shih
YS
D000328:Adult; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007247:Infertility, Female / Q000150:complications / Q000503:physiopathology; D016015:Logistic Models; D015999:Multivariate Analysis; D016471:Ovarian Hyperstimulation Syndrome / Q000150:complications; D011247:Pregnancy; D011256:Pregnancy Outcome; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies; D012307:Risk Factors; D013624:Taiwan