title: The global introduction of inactivated polio vaccine can circumvent the oral polio vaccine paradox.
abstract: This literature review identifies the factors that influence the decision to introduce inactivated polio vaccine (IPV) in developing countries as opposed to the policy of vaccine cessation. Attenuated viruses in the oral polio vaccine (OPV) can replicate, revert to neurovirulence and become transmissible circulating vaccine-derived polioviruses (cVDPVs), preventing use of the vaccine in the post-eradication era. This literature review identifies (1) risks of complete cessation of vaccination, (2) barriers and (3) solutions for the introduction of IPV in developing countries. The reviewed literature favours to circumvent the so-called "OPV paradox" by global introduction of IPV.
authors.affiliation: Athena Institute for Research on Innovation and Communication in Health and Life Sciences, Faculty of Earth and Life Sciences (FALW), VU University Amsterdam, De Boelelaan 1085, 1081 HV Amsterdam, The Netherlands. e_heinsbroek@hotmail.com
authors.forename: Ellen
authors.initials: E
authors.lastname: Heinsbroek
authors.forename: E Joost
authors.initials: EJ
authors.lastname: Ruitenberg
mesh_terms: D003906:Developing Countries; D006801:Humans; D017589:Immunization Programs; D011051:Poliomyelitis / Q000517:prevention & control*; D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects; D018570:Risk Assessment
chemical_list: D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral