title: Total synthesis of (+)-crocacin C.
abstract: Two approaches toward the total synthesis of cytotoxic polyketide natural product (+)-crocacin C (1) are described. The first approach, which was ultimately unsuccessful, was replaced altogether with a second that afforded target 1 in 10 linear steps from commercially available Evans' chiral propionimide (5% overall yield). No protecting groups were utilized in the total synthesis of 1.
authors.affiliation: Temple University, Department of Chemistry, Philadelphia, PA 19122, USA.
authors.forename: Gopal
authors.initials: G
authors.lastname: Sirasani
authors.forename: Tapas
authors.initials: T
authors.lastname: Paul
authors.forename: Rodrigo B
authors.initials: RB
authors.lastname: Andrade
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis*; D000577:Amides / Q000138:chemical synthesis*; D015394:Molecular Structure; D055601:Organic Chemistry Phenomena; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000577:Amides; C500918:crocacin C