title: Dodecaborate lipid liposomes as new vehicles for boron delivery system of neutron capture therapy.
abstract: Closo-dodecaborate lipid liposomes were developed as new vehicles for boron delivery system (BDS) of neutron capture therapy. The current approach is unique because the liposome shell itself possesses cytocidal potential in combination with neutron irradiation. The liposomes composed of closo-dodecaborate lipids DSBL and DPBL displayed high cytotoxicity with thermal neutron irradiation. The closo-dodecaborate lipid liposomes were taken up into the cytoplasm by endocytosis without degradation of the liposomes. Boron concentration of 22.7 ppm in tumor was achieved by injection with DSBL-25% PEG liposomes at 20mg B/kg. Promising BNCT effects were observed in the mice injected with DSBL-25% PEG liposomes: the tumor growth was significantly suppressed after thermal neutron irradiation (1.8 x 10(12)neutrons/cm(2)).
authors.affiliation: Department of Chemistry, Faculty of Science, Gakushuin University, Mejiro, Toshima-ku, Tokyo 171-8588, Japan.
authors.forename: Manabu
authors.initials: M
authors.lastname: Ueno
authors.forename: Hyun Seung
authors.initials: HS
authors.lastname: Ban
authors.forename: Kei
authors.initials: K
authors.lastname: Nakai
authors.forename: Ryu
authors.initials: R
authors.lastname: Inomata
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Kaneda
authors.forename: Akira
authors.initials: A
authors.lastname: Matsumura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakamura
mesh_terms: D000818:Animals; D001895:Boron / Q000008:administration & dosage*; D001896:Boron Compounds / Q000737:chemistry*; D016754:Boron Neutron Capture Therapy; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D005260:Female; D008055:Lipids / Q000737:chemistry*; D008081:Liposomes / Q000737:chemistry*; D051379:Mice; D008807:Mice, Inbred BALB C; D046529:Microscopy, Electron, Transmission; D009369:Neoplasms / Q000532:radiotherapy*; D019275:Radiopharmaceuticals; D014018:Tissue Distribution; D047368:Tumor Burden
chemical_list: D001896:Boron Compounds; D008055:Lipids; D008081:Liposomes; D019275:Radiopharmaceuticals; C119788:dodecaborate; D001895:Boron