title: Case report: massive blood transfusion in a patient with immunoglobulin a deficiency undergoing cesarean delivery.
abstract: Patients with immunoglobulin (Ig)A deficiency develop autoantibodies against IgA, which render them vulnerable to severe anaphylactic reactions when transfused with conventional blood or blood products containing IgA. In this report, we describe a patient with IgA deficiency and placenta accreta undergoing emergency cesarean delivery who required massive blood transfusion. We discuss the workup and treatment options in patients with known IgA deficiency.
authors.affiliation: Department of Anesthesiology, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033-0850, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Steel
authors.forename: Sonia
authors.initials: S
authors.lastname: Vaida
authors.forename: Berend
authors.initials: B
authors.lastname: Mets
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001034:Apgar Score; D001772:Blood Cell Count; D001803:Blood Transfusion; D002585:Cesarean Section; D004155:Diphenhydramine / Q000627:therapeutic use; D005260:Female; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D017098:IgA Deficiency / Q000628:therapy*; D007070:Immunoglobulin A / Q000032:analysis; D010921:Placenta Accreta / Q000601:surgery; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D006634:Histamine H1 Antagonists; D007070:Immunoglobulin A; D004155:Diphenhydramine