Biomonitoring of arsenic in urine and saliva of children playing on playgrounds constructed from chromated copper arsenate-treated wood.
Children may be exposed to arsenic during contact with structures treated with chromated copper arsenate (CCA). A high frequency of hand-to-mouth activity may increase their risk of ingesting arsenic. Previous work showed that arsenic concentrations in the hand-wash samples of children playing on CCA playgrounds were four times higher than those playing on non-CCA playgrounds. It is not clear whether playing on CCA playgrounds results in elevated overall exposure to arsenic. The objective of this study was to perform arsenic biomonitoring in children to determine whether playing on CCA-treated playgrounds substantially contributes to their overall exposure to arsenic. One hundred and twenty five saliva samples from 61 children and 101 urine samples from 45 children were collected after children played on 8 CCA and 8 non-CCA playgrounds. Arsenic speciation analysis was conducted using high performance liquid chromatography combined with inductively coupled plasma mass spectrometry. The arsenic species detected in the urine and saliva samples from children playing on CCA and non-CCA playgrounds were similar. Dimethylarsinic acid and arsenobetaine were the main arsenic species found in urine samples. The sum of inorganic trivalent and pentavalent arsenic, monomethylarsonic acid, and dimethylarsinic acid in urine was 15 +/- 28 microg/L in the CCA group and 12 +/- 23 microg/L in the non-CCA group (p = 0.60). The sum of these species in saliva was 1.1 +/- 2.1 microg/L in the CCA group and 1.4 +/- 1.1 microg/L in the non-CCA group (p = 0.32). These results show that there is no significant difference in the concentration or speciation of arsenic between the samples from children playing on CCA and non-CCA playgrounds. Contact with CCA playgrounds is not likely to significantly contribute to the overall arsenic exposure in children; other sources such as dietary arsenic may be a main contributor to their overall exposure.
Lew
Kristi
K
Department of Laboratory Medicine and Pathology, Analytical and Environmental Toxicology Division, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2G3.
Acker
Jason P
JP
Gabos
Stephan
S
Le
X Chris
XC
D001151:Arsenic / Q000032:analysis* / Q000652:urine; D002648:Child; D002840:Chromates / Q000737:chemistry*; D006801:Humans; D010988:Play and Playthings; D012463:Saliva / Q000737:chemistry*; D014934:Wood
D002840:Chromates; D001151:Arsenic