[Endocrine regulation in critically ill patients].
Disturbances of the hormonal regulation of critically ill patients are known since many years. In the last years, two topics received a lot of attention since a single intervention led to a mortality benefit: the intensive blood glucose control in surgical intensive care patients and the low dose hydrocortisone therapy in sepsis. These results were quickly incorporated in guidelines. However, large multi-center studies failed to support the initial results in several points. This review discusses these and other disturbances of endocrine regulation of critically ill patients.
Wrede
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CE
Interdisziplinäres Notfallzentrum mit Rettungsstelle, Helios-Klinikum Berlin-Buch. christian.wrede@helios-kliniken.de
D001786:Blood Glucose / Q000378:metabolism; D002986:Clinical Trials as Topic; D003422:Critical Care / Q000379:methods; D016638:Critical Illness; D004734:Energy Metabolism / Q000502:physiology; D006706:Homeostasis / Q000502:physiology; D020249:Hormone Replacement Therapy; D006728:Hormones / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007328:Insulin / Q000097:blood; D007362:Intensive Care Units; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D011379:Prognosis; D013312:Stress, Physiological / Q000502:physiology; D015996:Survival Rate; D013961:Thyroid Gland / Q000503:physiopathology*
D001786:Blood Glucose; D006728:Hormones; D007328:Insulin