[Expression of toll-like receptors signaling pathway in chronic rhinosinusitis with nasal polyps].
OBJECTIVE
To investigate the expression of Toll-like receptors (TLRs) signaling pathway in chronic rhinosinusitis (CRS) with nasal polyps.


METHODS
Gene microarray analysis was used to detect the expression of TLRs signaling pathway in CRS with nasal polyps.


RESULTS
Of 19 differentially expressed (two fold changes), 4 genes were upregulated and 15 genes were downregulated.


CONCLUSIONS
The differentially expressed genes in TLRs signaling pathway may exert its effect in the pathogenesis of CRS. In addition, the roles of TLR9 and its agonists need further study.
Wang
Xin
X
Department of Otorhinolaryngology Head and Neck Surgery, Second Hospital Affiliated to Harbin Medical Universitry, Harbin,150086, China.
Zhao
Chunyuan
C
Liu
Ming
M
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism; D009298:Nasal Polyps / Q000235:genetics / Q000378:metabolism*; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000235:genetics; D015398:Signal Transduction; D012852:Sinusitis / Q000235:genetics / Q000378:metabolism*; D051193:Toll-Like Receptors / Q000235:genetics / Q000378:metabolism*; D055815:Young Adult
D012333:RNA, Messenger; D051193:Toll-Like Receptors