[The inhibition effect of paclitaxel on the proliferation of human pulmonary fibroblasts].
OBJECTIVE
To observe the influence of paclitaxel on the proliferation of human pulmonary fibroblast (HPF), and therefore to explore the possible effect on granulation tissue formation in-stent restenosis after airway stent.


METHODS
The HPFS were divided into 3 groups: 24 h group, 48 h group and 72 h group, and there were 3 different dosage groups in each time group. MTT assay was used for detecting cell proliferation.


RESULTS
The inhibition ratio of 4.5 microg/ml group, 13.5 microg/ml group and 45 microg/ml group were 43.7%, 58.8% and 68.1% after 24 hours; 75.5%, 77.7%, 91.9% after 48 hours; 95.1%, 97.1%, 97.0% after 72 hours.


CONCLUSIONS
Paclitaxel inhibited the proliferation of HPF, and the inhibition ratio has partly relation with time and dosage.
Wang
Ting
T
Department of Respiratory Medicine, Beijing Tiantan Hospital, Affiliated Hospital of Capital Medical University, Beijing 100050, China.
Zhang
Jie
J
Wang
Juan
J
Pei
Ying-Hua
YH
Xu
Min
M
Zhang
Xia
X
Wang
Yu-Ling
YL
D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D054855:Drug-Eluting Stents; D005347:Fibroblasts / Q000187:drug effects*; D006097:Granulation Tissue; D006801:Humans; D008168:Lung / Q000166:cytology / Q000196:embryology; D017239:Paclitaxel / Q000494:pharmacology*
D017239:Paclitaxel