Pathogenicity, virulence factors, and strategies  to fight against Burkholderia cepacia complex pathogens  and related species.
The Burkholderia cepacia complex (Bcc) is a group of 17 closely related species of the beta-proteobacteria subdivision that emerged in the 1980s as important human pathogens, especially to patients suffering from cystic fibrosis. Since then, a remarkable progress has been achieved on the taxonomy and molecular identification of these bacteria. Although some progress have been achieved on the knowledge of the pathogenesis traits and virulence factors used by these bacteria, further work envisaging the identification of potential targets for the scientifically based design of new therapeutic strategies is urgently needed, due to the very difficult eradication of these bacteria with available therapies. An overview of these aspects of Bcc pathogenesis and opportunities for the design of future therapies is presented and discussed in this work.
Leitão
Jorge H
JH
IBB-Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal. jorgeleitao@ist.utl.pt
Sousa
Sílvia A
SA
Ferreira
Ana S
AS
Ramos
Christian G
CG
Silva
Inês N
IN
Moreira
Leonilde M
LM
D000818:Animals; D019121:Burkholderia Infections / Q000382:microbiology / Q000628:therapy*; D042602:Burkholderia cepacia complex / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000472:pathogenicity*; D004195:Disease Models, Animal; D024881:Drug Resistance, Bacterial; D006801:Humans; D037521:Virulence Factors / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*
D037521:Virulence Factors