Comment on "Modafinil shifts human locus coeruleus to low-tonic, high-phasic activity during functional MRI" and "Homeostatic sleep pressure and responses to sustained attention in the suprachiasmatic area".
Minzenberg et al. (Reports, 12 December 2008, p. 1700) and Schmidt et al. (Reports, 24 April 2009, p. 516) reported blood oxygen level-dependent (BOLD) responses in the human locus coeruleus (LC). Here, we show that these LC responses do not correspond to the anatomical location of the LC and present cautionary data concerning the quality of BOLD signals measured from the LC using standard functional magnetic resonance imaging acquisition parameters.
Astafiev
Serguei V
SV
Department of Radiology, Washington University in St. Louis, Box 8225, St. Louis, MO 63110, USA.
Snyder
Abraham Z
AZ
Shulman
Gordon L
GL
Corbetta
Maurizio
M
D001288:Attention; D001559:Benzhydryl Compounds / Q000494:pharmacology; D001931:Brain Mapping; D001933:Brain Stem / Q000033:anatomy & histology; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D006706:Homeostasis; D006801:Humans; D008125:Locus Coeruleus / Q000033:anatomy & histology* / Q000187:drug effects / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008543:Melanins / Q000032:analysis; D000077408:Modafinil; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D010100:Oxygen / Q000097:blood; D012890:Sleep; D013493:Suprachiasmatic Nucleus / Q000502:physiology
D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D008543:Melanins; C014121:neuromelanin; D000077408:Modafinil; D010100:Oxygen
Science. 2008 Feb 29;319(5867):1264-7
18309087
Neuroreport. 2008 Nov 19;19(17):1649-54
18852680
J Neurosci. 1996 Aug 15;16(16):5196-204
8756448
J Neurosci. 2009 Apr 8;29(14):4392-407
19357267
Neuroreport. 2006 Jul 31;17(11):1215-8
16837857
J Neurosci. 1988 May;8(5):1776-88
3367220
Science. 2008 Dec 12;322(5908):1700-2
19074351
Annu Rev Neurosci. 2005;28:403-50
16022602
Exp Brain Res. 1989;77(2):257-70
2571514
Neuroimage. 2009 Oct 1;47(4):1261-7
19524044
Magn Reson Med Sci. 2008;7(4):205-10
19110515
Science. 2009 Apr 24;324(5926):516-9
19390047