title: Primary pulmonary coccidioidomycosis in China.
abstract: Coccidioidomycosis is a fungal infection endemic to south-west USA, north Mexico and parts of Central and South America. We report here a case of primary pulmonary coccidioidomycosis in a previously healthy 14-year-old boy in China, which is considered a non-endemic country. The patient had non-specific symptoms of pulmonary infection, including fever, non-productive cough and night sweats. Both spherules and endospores of Coccidioides immitis were seen histologically following transbronchial biopsy of a cavitary lesion. The patient was treated with amphotericin B and fluconazole. Follow up 6 months post discharge found that the patient made a good recovery.
authors.affiliation: Department of Respiratory Medicine, Tongji Hospital, Key Laboratory of Pulmonary Diseases of Ministry of Health of China, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Fen
authors.initials: F
authors.lastname: Lan
authors.forename: Yao-Zhi
authors.initials: YZ
authors.lastname: Tong
authors.forename: Hong
authors.initials: H
authors.lastname: Huang
authors.forename: Wei-Ning
authors.initials: WN
authors.lastname: Xiong
authors.forename: Yong-Jian
authors.initials: YJ
authors.lastname: Xu
authors.forename: Sheng-Dao
authors.initials: SD
authors.lastname: Xiong
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use*; D044466:Asian People; D003045:Coccidioides / Q000302:isolation & purification; D003047:Coccidioidomycosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D003371:Cough / Q000188:drug therapy / Q000473:pathology; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D008172:Lung Diseases, Fungal / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D016896:Treatment Outcome
chemical_list: D000666:Amphotericin B; D015725:Fluconazole