Dysfunctional endothelial progenitor cells in chronic kidney disease.
Putative endothelial progenitor cells play a role in organ regeneration, and their incompetence may be important in the development of chronic kidney disease. The mechanisms of this incompetence are broad and range from poor mobilization, viability, and engraftment to impaired differentiation into mature endothelial cells. By contrasting the role of endothelial progenitor cells in tissue regeneration with their developing incompetence in chronic kidney disease, we emphasize the importance of designing rational pharmacologic strategies to tackle such incompetence in the broader search for therapies to attenuate chronic disease.
Goligorsky
Michael S
MS
Renal Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA. michael_goligorsky@nymc.edu
Yasuda
Kaoru
K
Ratliff
Brian
B
D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002908:Chronic Disease; D042783:Endothelial Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000502:physiology; D007674:Kidney Diseases / Q000473:pathology / Q000503:physiopathology*; D012038:Regeneration / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*