title: A visual migraine aura locus maps to 9q21-q22.
abstract: OBJECTIVE
  To identify susceptibility loci for visual migraine aura in migraine families primarily affected with scintillating scotoma type of aura.
  
  
  METHODS
  We included Finnish migraine families with at least 2 affected family members with scintillating scotoma as defined by the International Criteria for Headache Disorders-II. A total of 36 multigenerational families containing 351 individuals were included, 185 of whom have visual aura and 159 have scintillating scotoma. Parametric and nonparametric linkage analyses were performed with 378 microsatellite markers. The most promising linkage loci found were fine-mapped with additional microsatellite markers.
  
  
  RESULTS
  A novel locus on chromosome 9q22-q31 for migraine aura was identified (HLOD = 4.7 at 104 cM). Fine-mapping identified a shared haplotype segment of 12 cM (9.8 Mb) on 9q21-q22 among the aura affected. Four other loci showed linkage to aura: a locus on 12p13 showed significant evidence of linkage, and suggestive evidence of linkage was detected to loci on chromosomes 5q13, 6q25, and 13q14.
  
  
  CONCLUSIONS
  A novel visual migraine aura locus has been mapped to chromosome 9q21-q22. Interestingly, this region has previously been linked to occipitotemporal lobe epilepsy with prominent visual symptoms. Our finding further supports a shared genetic background in migraine and epilepsy and suggests that susceptibility variant(s) to visual aura for both of these traits are located in the 9q21-q22 locus.
authors.affiliation: Folkhälsan Research Center, Biomedicum Helsinki, PO Box 63, 00014 University of Helsinki, Finland. maija.wessman@helsinki.fi
authors.forename: P
authors.initials: P
authors.lastname: Tikka-Kleemola
authors.forename: V
authors.initials: V
authors.lastname: Artto
authors.forename: S
authors.initials: S
authors.lastname: Vepsäläinen
authors.forename: E M
authors.initials: EM
authors.lastname: Sobel
authors.forename: S
authors.initials: S
authors.lastname: Räty
authors.forename: M A
authors.initials: MA
authors.lastname: Kaunisto
authors.forename: V
authors.initials: V
authors.lastname: Anttila
authors.forename: E
authors.initials: E
authors.lastname: Hämäläinen
authors.forename: M-L
authors.initials: ML
authors.lastname: Sumelahti
authors.forename: M
authors.initials: M
authors.lastname: Ilmavirta
authors.forename: M
authors.initials: M
authors.lastname: Färkkilä
authors.forename: M
authors.initials: M
authors.lastname: Kallela
authors.forename: A
authors.initials: A
authors.lastname: Palotie
authors.forename: M
authors.initials: M
authors.lastname: Wessman
mesh_terms: D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005387:Finland; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D020325:Migraine with Aura / Q000235:genetics*; D009460:Neurologic Examination; D010375:Pedigree; D012607:Scotoma / Q000235:genetics*; D012737:Sex Factors
references.citation: Neurol Sci. 2007 May;28 Suppl 2:S150-5
references.pmid: 17508163
references.citation: Lancet Neurol. 2007 Jun;6(6):521-32
references.pmid: 17509487
references.citation: Eur J Neurol. 2001 Jan;8(1):61-6
references.pmid: 11509082
references.citation: Science. 2008 Nov 7;322(5903):881-8
references.pmid: 18988837
references.citation: Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4687-92
references.pmid: 11287655
references.citation: Am J Hum Genet. 2003 Nov;73(5):986-93
references.pmid: 14513409
references.citation: Am J Hum Genet. 2008 May;82(5):1051-63
references.pmid: 18423523
references.citation: J Neurosci Res. 2005 Jun 1;80(5):715-26
references.pmid: 15880382
references.citation: Hum Mol Genet. 2008 Nov 1;17(21):3318-31
references.pmid: 18676988
references.citation: J Neurophysiol. 1947 Nov;10(6):409-14
references.pmid: 20268874
references.citation: Am J Hum Genet. 1996 Jun;58(6):1347-63
references.pmid: 8651312
references.citation: Neurology. 1994 Nov;44(11):2105-10
references.pmid: 7969967
references.citation: Hum Mol Genet. 2003 Oct 1;12(19):2511-7
references.pmid: 12915447
references.citation: Am J Hum Genet. 1998 Jul;63(1):259-66
references.pmid: 9634505
references.citation: J Headache Pain. 2006 Oct;7(5):324-30
references.pmid: 17058048
references.citation: Am J Hum Genet. 2006 Jul;79(1):85-99
references.pmid: 16773568
references.citation: Proc Natl Acad Sci U S A. 1984 Jun;81(11):3443-6
references.pmid: 6587361
references.citation: Proc Natl Acad Sci U S A. 1989 Jun;86(11):4175-8
references.pmid: 2726769
references.citation: Dev Med Child Neurol. 2008 Sep;50(9):648-54
references.pmid: 18754913
references.citation: Ann Neurol. 2006 Jan;59(1):210-3
references.pmid: 16374824
references.citation: Am J Hum Genet. 2003 Jan;72(1):161-7
references.pmid: 12474141
references.citation: Am J Hum Genet. 1997 Nov;61(5):1179-88
references.pmid: 9345087
references.citation: J Neurol Neurosurg Psychiatry. 2005 Dec;76(12):1730-2
references.pmid: 16291905
references.citation: Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15476-81
references.pmid: 15494442
references.citation: Am J Hum Genet. 1996 Jun;58(6):1323-37
references.pmid: 8651310
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2008 Oct 5;147B(7):1186-95
references.pmid: 18361423
references.citation: Cephalalgia. 2008 Feb;28(2):105-13
references.pmid: 18197881
references.citation: Curr Protoc Bioinformatics. 2007 Mar;Chapter 1:Unit 1.4
references.pmid: 18428780
references.citation: Am J Hum Genet. 2005 Sep;77(3):500-12
references.pmid: 16080125
references.citation: Am J Hum Genet. 2002 Mar;70(3):652-62
references.pmid: 11836652
references.citation: Headache. 2006 Oct;46(9):1327-33
references.pmid: 17040330
references.citation: Neurology. 2002 Dec 10;59(11):1804-7
references.pmid: 12473779
references.citation: Am J Hum Genet. 2002 Feb;70(2):496-508
references.pmid: 11791215
references.citation: Neurology. 2007 Jun 5;68(23):1995-2002
references.pmid: 17460155
references.citation: Cephalalgia. 2004;24 Suppl 1:9-160
references.pmid: 14979299
references.citation: Curr Opin Neurol. 2008 Jun;21(3):288-93
references.pmid: 18451712
references.citation: Twin Res Hum Genet. 2005 Feb;8(1):16-21
references.pmid: 15836805