title: Biological activities of phenolic compounds present in virgin olive oil.
abstract: The Mediterranean diet is associated with a lower incidence of atherosclerosis, cardiovascular disease, neurodegenerative diseases and certain types of cancer. The apparent health benefits have been partially ascribed to the dietary consumption of virgin olive oil by Mediterranean populations. Much research has focused on the biologically active phenolic compounds naturally present in virgin olive oils to aid in explaining reduced mortality and morbidity experienced by people consuming a traditional Mediterranean diet. Studies (human, animal, in vivo and in vitro) have demonstrated that olive oil phenolic compounds have positive effects on certain physiological parameters, such as plasma lipoproteins, oxidative damage, inflammatory markers, platelet and cellular function, antimicrobial activity and bone health. This paper summarizes current knowledge on the bioavailability and biological activities of olive oil phenolic compounds.
authors.affiliation: Deakin University, Melbourne, Australia. cicerale@deakin.edu.au
authors.forename: Sara
authors.initials: S
authors.lastname: Cicerale
authors.forename: Lisa
authors.initials: L
authors.lastname: Lucas
authors.forename: Russell
authors.initials: R
authors.lastname: Keast
mesh_terms: D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D002986:Clinical Trials as Topic; D004249:DNA Damage / Q000187:drug effects; D006801:Humans; D008055:Lipids / Q000097:blood; D000069463:Olive Oil; D010012:Osteogenesis / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology; D010938:Plant Oils / Q000737:chemistry*
chemical_list: D008055:Lipids; D000069463:Olive Oil; D010636:Phenols; D010938:Plant Oils
references.citation: J Sep Sci. 2005 Jun;28(9-10):837-58
references.pmid: 16013811
references.citation: Int J Cancer. 2005 Oct 20;117(1):1-7
references.pmid: 15880398
references.citation: Int J Cancer. 1994 Sep 15;58(6):774-80
references.pmid: 7927867
references.citation: J Neurochem. 2009 Aug;110(4):1339-51
references.pmid: 19549281
references.citation: Circulation. 2001 Apr 3;103(13):1823-5
references.pmid: 11282918
references.citation: J Agric Food Chem. 2002 Nov 6;50(23):6812-7
references.pmid: 12405780
references.citation: J Agric Food Chem. 2001 Nov;49(11):5502-8
references.pmid: 11714351
references.citation: J Agric Food Chem. 1998 Jan 19;46(1):32-35
references.pmid: 10554192
references.citation: J Agric Food Chem. 2006 Oct 4;54(20):7641-51
references.pmid: 17002434
references.citation: Toxicol Ind Health. 2009 May-Jun;25(4-5):301-10
references.pmid: 19651801
references.citation: J Nutr Biochem. 2002 Nov;13(11):636-644
references.pmid: 12550060
references.citation: J Agric Food Chem. 2002 Jan 30;50(3):571-7
references.pmid: 11804531
references.citation: N Engl J Med. 2003 Jun 26;348(26):2599-608
references.pmid: 12826634
references.citation: N Engl J Med. 2003 Jun 26;348(26):2595-6
references.pmid: 12826632
references.citation: Eur J Cancer. 2000 Jun;36(10):1235-47
references.pmid: 10882862
references.citation: Mol Nutr Food Res. 2009 Jul;53(7):897-903
references.pmid: 19685549
references.citation: J Agric Food Chem. 2007 Feb 7;55(3):680-6
references.pmid: 17263460
references.citation: Int J Cardiol. 2007 Oct 31;122(1):29-33
references.pmid: 17188378
references.citation: Atherosclerosis. 2006 Feb;184(2):389-96
references.pmid: 16019008
references.citation: J Nutr. 2002 Mar;132(3):409-17
references.pmid: 11880564
references.citation: Ann Oncol. 2007 Jan;18(1):36-39
references.pmid: 17018706
references.citation: Thromb Res. 2000 Nov 15;100(4):305-15
references.pmid: 11113274
references.citation: Clin Chem. 2001 Feb;47(2):341-3
references.pmid: 11159787
references.citation: J Nutr. 2004 Sep;134(9):2314-21
references.pmid: 15333722
references.citation: Eur J Nutr. 2007 Mar;46(2):70-8
references.pmid: 17200875
references.citation: Eur J Clin Invest. 1998 Oct;28(10):787-92
references.pmid: 9792990
references.citation: J Nutr. 2006 Mar;136(3):614-9
references.pmid: 16484533
references.citation: Toxicol Appl Pharmacol. 2009 Oct 15;240(2):189-97
references.pmid: 19631677
references.citation: Eur J Clin Nutr. 2003 Jan;57(1):191
references.pmid: 12548316
references.citation: Circulation. 1999 Feb 16;99(6):779-85
references.pmid: 9989963
references.citation: FASEB J. 2007 Jan;21(1):45-52
references.pmid: 17110467
references.citation: Int J Cancer. 2008 Feb 1;122(3):495-500
references.pmid: 17943720
references.citation: Life Sci. 2001 Jul 27;69(10):1213-22
references.pmid: 11508353
references.citation: J Agric Food Chem. 1999 Sep;47(9):3535-40
references.pmid: 10552681
references.citation: Free Radic Res. 2001 Mar;34(3):301-5
references.pmid: 11264904
references.citation: Biochem Biophys Res Commun. 2000 Nov 30;278(3):797-9
references.pmid: 11095986
references.citation: Free Radic Biol Med. 2003 Nov 1;35(9):1073-81
references.pmid: 14572610
references.citation: J Nutr. 1997 Feb;127(2):286-92
references.pmid: 9039829
references.citation: Eur J Clin Nutr. 2002 Oct;56(10):1024-9
references.pmid: 12373624
references.citation: Nutr Cancer. 2003;46(1):30-7
references.pmid: 12925301
references.citation: Int J Oncol. 2009 Jan;34(1):43-51
references.pmid: 19082476
references.citation: Cytotechnology. 2009 Jan;59(1):45-53
references.pmid: 19353300
references.citation: J Am Coll Cardiol. 2005 Nov 15;46(10):1864-8
references.pmid: 16286173
references.citation: Br J Nutr. 1999 Jul;82(1):31-9
references.pmid: 10655954
references.citation: Eur J Clin Nutr. 2002 Feb;56(2):114-20
references.pmid: 11857044
references.citation: Circulation. 2000 Oct 31;102(18):2169-71
references.pmid: 11056087
references.citation: Nutr Res Rev. 2005 Jun;18(1):98-112
references.pmid: 19079898
references.citation: Crit Rev Food Sci Nutr. 2009 Mar;49(3):218-36
references.pmid: 19093267
references.citation: Atherosclerosis. 1995 Sep;117(1):25-32
references.pmid: 8546752
references.citation: J Agric Food Chem. 2002 Sep 25;50(20):5566-70
references.pmid: 12236680
references.citation: Br J Nutr. 2001 Sep;86(3):349-57
references.pmid: 11570987
references.citation: Atherosclerosis. 2007 Jan;190(1):181-6
references.pmid: 16488419
references.citation: BMC Cancer. 2007 May 09;7:80
references.pmid: 17490486
references.citation: Crit Rev Food Sci Nutr. 2002;42(3):209-21
references.pmid: 12058980
references.citation: Ann Nutr Metab. 1998;42(5):251-60
references.pmid: 9812015
references.citation: Nutrition. 2002 Jan;18(1):60-5
references.pmid: 11827767
references.citation: Mol Nutr Food Res. 2009 May;53(5):609-16
references.pmid: 19340892
references.citation: Br J Nutr. 2006 Apr;95(4):742-51
references.pmid: 16571154
references.citation: J Agric Food Chem. 2009 May 13;57(9):3478-82
references.pmid: 19358606
references.citation: Ann Intern Med. 2006 Sep 5;145(5):333-41
references.pmid: 16954359
references.citation: J Agric Food Chem. 2005 Oct 5;53(20):8054-62
references.pmid: 16190670
references.citation: J Agric Food Chem. 2008 Oct 22;56(20):9417-22
references.pmid: 18800805
references.citation: J Pharm Pharmacol. 1999 Aug;51(8):971-4
references.pmid: 10504039
references.citation: J Nutr. 2008 Aug;138(8):1411-6
references.pmid: 18641183
references.citation: J Agric Food Chem. 2001 Nov;49(11):5609-14
references.pmid: 11714367
references.citation: Metabolism. 2001 Dec;50(12):1426-8
references.pmid: 11735087
references.citation: Eur J Nutr. 2004 Jun;43(3):140-7
references.pmid: 15168036
references.citation: Nature. 2005 Sep 1;437(7055):45-6
references.pmid: 16136122
references.citation: J Nutr. 2000 Dec;130(12):2996-3002
references.pmid: 11110859
references.citation: Nutr Rev. 2002 Jun;60(6):170-6
references.pmid: 12078915
references.citation: Eur J Clin Invest. 1994 Feb;24 Suppl 1:25-9
references.pmid: 7516879
references.citation: J Agric Food Chem. 2002 Feb 27;50(5):1077-80
references.pmid: 11853484
references.citation: Clin Nutr. 2001 Jun;20(3):211-5
references.pmid: 11407867
references.citation: J Nutr. 2003 Aug;133(8):2532-6
references.pmid: 12888632
references.citation: Am J Clin Nutr. 2004 Oct;80(4):1012-8
references.pmid: 15447913
references.citation: Am J Clin Nutr. 1995 Jun;61(6 Suppl):1402S-1406S
references.pmid: 7754995
references.citation: Lancet. 2002 Nov 9;360(9344):1455-61
references.pmid: 12433513
references.citation: Toxicol Ind Health. 2009 May-Jun;25(4-5):285-93
references.pmid: 19651799
references.citation: Biochem Biophys Res Commun. 2005 Dec 23;338(3):1368-73
references.pmid: 16263083
references.citation: Altern Med Rev. 2001 Jun;6(3):248-71
references.pmid: 11410071
references.citation: Br J Nutr. 2008 May;99(5):945-51
references.pmid: 17927845
references.citation: J Agric Food Chem. 2009 Mar 11;57(5):1793-6
references.pmid: 19219997
references.citation: J Agric Food Chem. 2002 Oct 9;50(21):5962-7
references.pmid: 12358466
references.citation: J Nutr. 2001 Jul;131(7):1993-6
references.pmid: 11435519
references.citation: Eur J Clin Nutr. 2005 May;59(5):727-30
references.pmid: 15798774
references.citation: Lipids. 2000 Jan;35(1):45-54
references.pmid: 10695923
references.citation: J Agric Food Chem. 2006 Sep 20;54(19):7130-6
references.pmid: 16968073
references.citation: Eur J Nutr. 2004 Mar;43 Suppl 1:I/2-5
references.pmid: 15052492
references.citation: FEBS Lett. 2000 Mar 31;470(3):341-4
references.pmid: 10745093
references.citation: Eur J Clin Nutr. 2008 Apr;62(4):570-4
references.pmid: 17375118
references.citation: J Agric Food Chem. 1999 Feb;47(2):417-24
references.pmid: 10563910
references.citation: Eur J Nutr. 2005 Mar;44(2):121-7
references.pmid: 15309433
references.citation: Clin Chem. 2008 Jan;54(1):24-38
references.pmid: 18160725
references.citation: Electrophoresis. 2005 Sep;26(18):3538-51
references.pmid: 16167367
references.citation: Atherosclerosis. 2005 Jul;181(1):149-58
references.pmid: 15939067
references.citation: J Agric Food Chem. 2003 Jan 29;51(3):667-72
references.pmid: 12537439
references.citation: Lancet. 1994 Sep 17;344(8925):793-5
references.pmid: 7916078
references.citation: FEBS Lett. 2000 Feb 25;468(2-3):159-60
references.pmid: 10692578
references.citation: Nutr Metab Cardiovasc Dis. 2000 Jun;10(3):111-20
references.pmid: 11006919
references.citation: Nature. 2001 May 17;411(6835):342-8
references.pmid: 11357141
references.citation: J Nutr Biochem. 2006 Jul;17(7):429-45
references.pmid: 16481154
references.citation: Clin Nutr. 2004 Aug;23(4):673-81
references.pmid: 15297105
references.citation: J Agric Food Chem. 2002 Oct 9;50(21):6102-8
references.pmid: 12358487
references.citation: J Agric Food Chem. 2002 Sep 11;50(19):5349-54
references.pmid: 12207473
references.citation: Arterioscler Thromb Vasc Biol. 2003 Apr 1;23(4):622-9
references.pmid: 12615669
references.citation: J Nutr Biochem. 2010 Apr;21(4):290-6
references.pmid: 19369055
references.citation: Thromb Res. 1995 Apr 15;78(2):151-60
references.pmid: 7482432
references.citation: J Agric Food Chem. 2009 Feb 25;57(4):1326-30
references.pmid: 19166297
references.citation: Arch Intern Med. 1981 Aug;141(9):1128-31
references.pmid: 7259370
references.citation: J Nutr. 2006 Nov;136(11):2844-8
references.pmid: 17056811
references.citation: Bioorg Chem. 2007 Apr;35(2):137-52
references.pmid: 17078995
references.citation: Circulation. 2009 Mar 3;119(8):1093-100
references.pmid: 19221219
references.citation: Am J Clin Nutr. 1995 Jun;61(6 Suppl):1416S-1427S
references.pmid: 7754997
references.citation: Carcinogenesis. 2008 Jan;29(1):139-46
references.pmid: 17999988
references.citation: J Agric Food Chem. 2006 Jul 12;54(14):4954-61
references.pmid: 16819902
references.citation: Anal Chim Acta. 2007 Feb 5;583(2):402-10
references.pmid: 17386573
references.citation: Br J Nutr. 2007 Dec;98(6):1243-50
references.pmid: 17617938
references.citation: J Nutr. 2004 Apr;134(4):785-91
references.pmid: 15051826
references.citation: Br J Nutr. 2002 Sep;88(3):225-34; discussion 223-4
references.pmid: 12207832
references.citation: J Agric Food Chem. 2006 Apr 19;54(8):3121-5
references.pmid: 16608240
references.citation: Am J Clin Nutr. 2007 Aug;86(2):341-6
references.pmid: 17684203
references.citation: Free Radic Biol Med. 2006 Feb 15;40(4):608-16
references.pmid: 16458191
references.citation: Neurosci Lett. 2008 Dec 3;446(2-3):143-6
references.pmid: 18809463
references.citation: J Agric Food Chem. 2004 Nov 3;52(22):6687-93
references.pmid: 15506801
references.citation: J Nutr. 1999 Dec;129(12):2177-83
references.pmid: 10573546
references.citation: Int J Mol Med. 2008 Oct;22(4):433-9
references.pmid: 18813848
references.citation: Eur J Clin Nutr. 2001 May;55(5):334-41
references.pmid: 11378806
references.citation: FASEB J. 2003 Jul;17(10):1195-214
references.pmid: 12832285