[Pathological study of radial sclerosing lesions].
OBJECTIVE
To investigate the pathological diagnostic features and the differential diagnosis of radial sclerosing lesions of the breast.


METHODS
Morphological observation and immunohistochemistry were applied to forty-four cases of radial sclerosing lesions of the breast.


RESULTS
All forty-four patients were females, the mean age was 40.3 years (range 17 to 54 years). In the 31 consultation cases, 13 were misdiagnosed as carcinoma. The lesions had a radiating outline, and a central scar area where squeezed or pressed irregular shaped tubules were frequently seen. Dilated tubules and proliferated ducts or lobules were seen radically arranged at the periphery accompanied sometimes with the apocrine glands or columnar cell metaplasia and hyperplasia. Aside, there were 14 cases displaying necroses and 8 cases showing atypical ductal hyperplasia. Immunostaining showed myoepithelial cells around the pseudo-infiltrating tubules, and the florid proliferating epithelial cells were positive for CK5/6.


CONCLUSIONS
Radial sclerosing lesions of the breast possess characteristic histological features, and may be misdiagnosed as carcinoma. The lesions should be differentiated from ductal carcinoma in situ, lobular neoplasia, tubular carcinoma and invasive ductal carcinoma.
Zhang
Xiao-li
XL
Shanxi Medical University, Taiyuan, China.
Yang
Guang-zhi
GZ
Ding
Hua-ye
HY
D000230:Adenocarcinoma / Q000473:pathology; D000293:Adolescent; D000328:Adult; D001940:Breast / Q000473:pathology*; D001941:Breast Diseases / Q000378:metabolism / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology; D002278:Carcinoma in Situ / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000473:pathology; D018275:Carcinoma, Lobular / Q000473:pathology; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D006801:Humans; D006965:Hyperplasia; D053547:Keratin-14 / Q000378:metabolism; D053555:Keratin-5 / Q000378:metabolism*; D007633:Keratins / Q000378:metabolism; D008875:Middle Aged; D012598:Sclerosis / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult
C121278:CK-34 beta E12; D053547:Keratin-14; D053555:Keratin-5; D007633:Keratins