New role for Agrin in T cells and its potential importance in immune system regulation.
Agrin plays a crucial role in the maintenance of the neuromuscular junction. However, it is expressed in other tissues as well, including T lymphocytes, where cell activation induces its expression. Agrin from activated T cells has the capacity to induce aggregation of key receptors and to regulate signalling. Interestingly, T cells isolated from patients with systemic lupus erythematosus over-express Agrin and its co-stimulation with the T cell receptor enhances production of pathogenic cytokines. These early studies point to an important function for Agrin in T cell biology and make the case for a more thorough and systematic investigation into its role in the immune system.
Jury
Elizabeth C
EC
Centre for Rheumatology, Royal Free and University College Medical School, University College London, London W1P 4JF, UK. e.jury@ucl.ac.uk
Kabouridis
Panagiotis S
PS
D018171:Agrin / Q000502:physiology*; D000938:Antigen-Presenting Cells / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000502:physiology*; D054992:Immunological Synapses / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
D018171:Agrin
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