Identification of natural product fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening.
Fonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure.
Lee
Ho-Man
HM
Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong.
Chan
Daniel Shiu-Hin
DS
Yang
Fang
F
Lam
Ho-Yu
HY
Yan
Siu-Cheong
SC
Che
Chi-Ming
CM
Ma
Dik-Lung
DL
Leung
Chung-Hang
CH
D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000737:chemistry; D054856:G-Quadruplexes; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000494:pharmacology; D057166:High-Throughput Screening Assays; D008024:Ligands; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*
D001688:Biological Products; D006575:Heterocyclic Compounds, 3-Ring; D008024:Ligands; D016271:Proto-Oncogene Proteins c-myc; C552278:fonsecin B; D004247:DNA