Preclinical study of proproten-100 for mutagenicity.
Experiments on CBA/CaLac mice showed that single and course administration of proproten-100 did not increase the percent of abnormal metaphases in red bone marrow cells and produced no genotoxic effects in Drosophila melanogaster wing cells in the test of somatic mosaicism.
Voronova
O L
OL
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Tomsk.
D000818:Animals; D000906:Antibodies / Q000009:adverse effects* / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D004330:Drosophila; D005260:Female; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009152:Mutagenicity Tests; D009153:Mutagens / Q000009:adverse effects*; D009418:S100 Proteins / Q000276:immunology
D000906:Antibodies; D009153:Mutagens; D009418:S100 Proteins