title: The phosphoinositide-3 kinase survival signaling mechanism in sepsis.
abstract: Phosphoinositide-3 kinases (PI3Ks) are critical regulatory proteins in the immunologic defense system against sepsis. The PI3K mechanism helps modulate cellular survival, innate and adaptive immunities, inflammation, nuclear factor-κB transcription, and may, in turn, play a protective role in sepsis. Animal studies confirm its role in the prevention of organ dysfunction and improvement of survival outcomes. Further advances in the understanding of this key immunomodulatory pathway may provide valuable insights into the manipulation of cellular function for therapeutic treatment of sepsis and other inflammatory diseases.
authors.affiliation: Clarian Cardiovascular Surgery, Methodist Hospital, Indianapolis, Indiana, USA.
authors.forename: Mariuxi C
authors.initials: MC
authors.lastname: Manukyan
authors.forename: Brent R
authors.initials: BR
authors.lastname: Weil
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Abarbanell
authors.forename: Jeremy L
authors.initials: JL
authors.lastname: Herrmann
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Poynter
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Meldrum
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002470:Cell Survival; D004789:Enzyme Activation; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000201:enzymology; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009102:Multiple Organ Failure / Q000201:enzymology / Q000209:etiology / Q000517:prevention & control; D016328:NF-kappa B / Q000502:physiology; D010538:Peritonitis / Q000201:enzymology / Q000276:immunology / Q000503:physiopathology; D019869:Phosphatidylinositol 3-Kinases / Q000276:immunology / Q000502:physiology*; D020033:Protein Isoforms / Q000502:physiology; D011494:Protein Kinases / Q000502:physiology; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology; D018805:Sepsis / Q000150:complications / Q000201:enzymology* / Q000276:immunology / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology
chemical_list: D016328:NF-kappa B; D020033:Protein Isoforms; D011494:Protein Kinases; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt