title: Congenital tracheal atresia in newborn: case report and review of the literature.
abstract: Tracheal atresia is an uncommon congenital malformation with a high mortality rate. Clinical symptoms occur suddenly after birth. The diagnosis is suspected in any infant in whom improved ventilation is obtained despite aggressive attempts at resuscitation. We describe a small gestational week 34 male newborn affected by tracheal atresia without esophageal fistula with associated fetal growth restriction, ascites and polyhydramnios. Post mortem examination revealed a diffuse cyanotic status, abdominal ascites and a low birth weight. A 3 cm tract of trachea was documented that distantly ended in a blind pouch and without tracheoesophageal fistulae and enlarged bulky lungs connected to each other by a common thin-walled bronchus. Histological examination showed a normal conformed larynx and scratchily cartilaginous disks in the proximal tract of the short trachea. Vascular space referred to small arteries and veins, thin bands of fibrous tissue and adipose tissue were detected under the blind pouch. Lung distal airspaces were lined by premature cubic epithelium separated by a broad poorly vascularized interstitium. A striking interstitial and alveolar edema was remarkable.
authors.affiliation: Dipartimento Integrato Servizi Diagnostici e di Laboratorio e di Medicina Legale, Sezione di Anatomia Patologica, Università di Modena e Reggio Emilia, Modena.
authors.forename: M
authors.initials: M
authors.lastname: Lupi
authors.forename: L Reggiani
authors.initials: LR
authors.lastname: Bonetti
authors.forename: N
authors.initials: N
authors.lastname: Trani
authors.forename: L
authors.initials: L
authors.lastname: Maccio
authors.forename: A
authors.initials: A
authors.lastname: Maiorana
mesh_terms: D000015:Abnormalities, Multiple / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000473:pathology*; D008297:Male; D014132:Trachea / Q000002:abnormalities*; D014133:Tracheal Diseases / Q000151:congenital*