title: The anatomy and physiology of the suspensory apparatus of the distal phalanx.
abstract: The equine hoof capsule protects the softer, more sensitive, structures within. Failure of the connection between hoof and bone (suspensory apparatus of the distal phalanx or SADP) results in the crippling lameness of laminitis. Active basal cell proliferation occurs principally in tubular hoof and proximal and distal lamellae. The remaining lamellae are virtually non-proliferative and the hoof wall moves past the stationary distal phalanx, by controlled activation and inhibition of constituent proteases. The lamellar corium derives most of its blood supply from the branches of the terminal arch which perforate the distal phalanx. Valveless veins within the foot can be exploited clinically for retrograde venous therapy or contrast radiography (venography). The basement membrane (BM) forms the interface between the lamellar epidermis and the adjacent dermis and the plasma membrane of each lamellar basal cell is attached to the BM by numerous electron dense adhesion plaques or hemidesmosomes the ultimate attachment unit of the SADP. Laminitis destroys and dislocates the BM and its components and without an intact, functional BM, the structure and function of the lamellar epidermis is pathologically compromised. Transcription and activation of constituent proteases occurs in normal hoof lamellae but in increased amounts during laminitis.
authors.affiliation: School of Veterinary Science, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia. c.pollitt@mailbox.uq.edu.au
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Pollitt
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000033:anatomy & histology / Q000502:physiology; D005534:Foot Diseases / Q000209:etiology / Q000662:veterinary; D022002:Hemidesmosomes; D006724:Hoof and Claw / Q000033:anatomy & histology / Q000098:blood supply / Q000294:innervation / Q000502:physiology; D006734:Horse Diseases / Q000209:etiology; D006736:Horses / Q000033:anatomy & histology / Q000502:physiology; D008022:Ligaments / Q000033:anatomy & histology / Q000502:physiology; D008023:Ligaments, Articular / Q000033:anatomy & histology* / Q000502:physiology*; D050277:Toe Phalanges / Q000033:anatomy & histology* / Q000502:physiology*