Cytotoxic nor-chamigrane and chamigrane endoperoxides from a basidiomycetous fungus.
A new nor-chamigrane endoperoxide, merulin A (1), and two new chamigrane endoperoxides, merulins B and C (2, 3), were isolated from the culture broth extract of an endophytic fungus of Xylocarpus granatum. Their structures were elucidated on the basis of spectroscopic, mainly NMR and MS, data. X-ray crystallographic analysis confirmed the structure of 1. Compounds 1 and 3 displayed significant cytotoxicity against human breast (BT474) and colon (SW620) cancer cell lines.
Chokpaiboon
Supichar
S
Program in Biotechnology, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand.
Sommit
Damrong
D
Teerawatananond
Thapong
T
Muangsin
Nongnuj
N
Bunyapaiboonsri
Taridaporn
T
Pudhom
Khanitha
K
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D001943:Breast Neoplasms / Q000188:drug therapy; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
D000970:Antineoplastic Agents; D010545:Peroxides; C550059:merulin A; C550060:merulin B; C550061:merulin C