title: Detection of atypical texture features in early malignant melanoma.
abstract: BACKGROUND
  The presence of an atypical (irregular) pigment network (APN) can indicate a diagnosis of melanoma. This study sought to analyze the APN with texture measures.
  
  
  METHODS
  For 106 dermoscopy images including 28 melanomas and 78 benign dysplastic nevi, the areas of APN were selected manually. Ten texture measures in the CVIPtools image analysis system were applied.
  
  
  RESULTS
  Of the 10 texture measures used, correlation average provided the highest discrimination accuracy, an average of 95.4%. Discrimination of melanomas was optimal at a pixel distance of 20 for the 768 x 512 images, consistent with a melanocytic lesion texel size estimate of 4-5 texels per mm.
  
  
  CONCLUSIONS
  Texture analysis, in particular correlation average at an optimized pixel spacing, may afford automatic detection of an irregular pigment network in early malignant melanoma.
authors.affiliation: Department of Electrical and Computer Engineering, Missouri University of Science and Technology, Rolla, MO, USA.
authors.forename: Bijaya
authors.initials: B
authors.lastname: Shrestha
authors.forename: Joseph
authors.initials: J
authors.lastname: Bishop
authors.forename: Keong
authors.initials: K
authors.lastname: Kam
authors.forename: Xiaohe
authors.initials: X
authors.lastname: Chen
authors.forename: Randy H
authors.initials: RH
authors.lastname: Moss
authors.forename: William V
authors.initials: WV
authors.lastname: Stoecker
authors.forename: Scott
authors.initials: S
authors.lastname: Umbaugh
authors.forename: R Joe
authors.initials: RJ
authors.lastname: Stanley
authors.forename: M Emre
authors.initials: ME
authors.lastname: Celebi
authors.forename: Ashfaq A
authors.initials: AA
authors.lastname: Marghoob
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Argenziano
authors.forename: H Peter
authors.initials: HP
authors.lastname: Soyer
mesh_terms: D002278:Carcinoma in Situ / Q000473:pathology; D016208:Databases, Factual; D046169:Dermoscopy / Q000379:methods* / Q000592:standards*; D003937:Diagnosis, Differential; D004416:Dysplastic Nevus Syndrome / Q000473:pathology*; D042241:Early Diagnosis; D006801:Humans; D018327:Hutchinson's Melanotic Freckle / Q000473:pathology; D007091:Image Processing, Computer-Assisted / Q000379:methods / Q000592:standards; D008545:Melanoma / Q000473:pathology*; D015203:Reproducibility of Results; D012878:Skin Neoplasms / Q000473:pathology*
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