Highly enantioselective relay catalysis in the three-component reaction for direct construction of structurally complex heterocycles.
A highly enantioselective three-component cascade reaction, consisting of an enantioselective [4+2] cycloaddition reaction catalyzed by chiral phosphoric acid and a subsequent catalytic intramolecular hydroamination by gold(I) complex, provides a unique method to access structurally diverse julolidine derivatives in high optical purity.
Wang
Chao
C
Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
Han
Zhi-Yong
ZY
Luo
Hong-Wen
HW
Gong
Liu-Zhu
LZ
D002384:Catalysis; D003500:Cyclization; D006046:Gold / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D010756:Phosphoric Acids / Q000737:chemistry*; D011807:Quinolizines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D010756:Phosphoric Acids; D011807:Quinolizines; D006046:Gold