Diorganotin(IV) derivatives of ONO tridentate Schiff base: synthesis, crystal structure, in vitro antimicrobial, anti-leishmanial and DNA binding studies.
Six new diorganotin(IV) derivatives of N'-(2-hydroxybenzylidene)formohydrazide (H(2)L) with general formula R(2)SnL, where R = Ph (1), Me (2), Bu (3), Oct (4), t-Bu (5), Et (6), and L = [OC(6)H(4)CHNNCHO] have been synthesized and characterized by different analytical techniques. Crystal structure of Me(2)SnL (2) authenticated distorted square-pyramidal geometry around the Sn atom. The CV and UV-Vis spectroscopic data indicated intercalation of complexes into DNA with binding affinity varying in the sequence: 3 (1.69 x 10(4) M(-1)) > 1 (1.10 x 10(4) M(-1)) > 2 (9.61 x 10(3) M(-1)). Some of these compounds were found to be good antibacterial, antifungal and leishmanicidal agents.
Shujha
Shaukat
S
Department of Chemistry, Quaid-i-Azam University, Islamabad 45320, Pakistan.
Shah
Afzal
A
Zia-Ur-Rehman
Muhammad
Niaz
N
Ali
Saqib
S
Qureshi
Rumana
R
Khalid
Nasir
N
Meetsma
Auke
A
D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology* / Q000633:toxicity; D001156:Artemia / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism; D004563:Electrochemistry; D005658:Fungi / Q000187:drug effects; D018320:Leishmania major / Q000187:drug effects*; D008958:Models, Molecular; D008968:Molecular Conformation; D009947:Organotin Compounds / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology* / Q000633:toxicity; D012545:Schiff Bases / Q000737:chemistry*; D013057:Spectrum Analysis
D000890:Anti-Infective Agents; D009947:Organotin Compounds; D012545:Schiff Bases; D004247:DNA