Benzodiazepine reception in C57BL/6 and BALB/c mice depending on the type of stress factor.
Specific binding of (3)H-flunitrazepam with synaptosomal membranes after exposure to open field test and "contact with predator" test was measured in C57Bl/6 and BALB/c mice. Stress-induced decrease in benzodiazepine binding after open field test was observed only in BALB/c mice and after contact with predator in both animal strains.
Chekina
K S
KS
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
Yarkova
M A
MA
Seredenin
S B
SB
D000818:Animals; D014151:Anti-Anxiety Agents / Q000378:metabolism*; D001007:Anxiety; D001522:Behavior, Animal / Q000502:physiology; D001569:Benzodiazepines / Q000378:metabolism*; D002415:Cats; D005239:Fear; D005260:Female; D005445:Flunitrazepam / Q000378:metabolism*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011869:Radioligand Assay; D013315:Stress, Psychological; D013574:Synaptosomes / Q000378:metabolism / Q000648:ultrastructure
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D005445:Flunitrazepam