title: Experimental study of hypotensive effect of kardos in rats with inherited hypertension.
abstract: Kardos, a preparation containing ultralow doses of antibodies to C-terminal fragment of type 1 receptor of angiotensin II, intragastrically administered to SHR rats with hereditary hypertension for 28 days reduced blood pressure by 14.8%. Kardos was not inferior to losartan and, in contrast to the latter reduced HR by 9.4%.
authors.affiliation: Biological Faculty, M V Lomonosov Moscow State University.
authors.forename: N A
authors.initials: NA
authors.lastname: Medvedeva
authors.forename: M M
authors.initials: MM
authors.lastname: Artem'eva
authors.forename: I A
authors.initials: IA
authors.lastname: Kheyfets
authors.forename: Yu L
authors.initials: YL
authors.lastname: Dugina
authors.forename: L B
authors.initials: LB
authors.lastname: Sabanov
authors.forename: Yu A
authors.initials: YA
authors.lastname: Zabolotneva
authors.forename: M V
authors.initials: MV
authors.lastname: Kachanova
authors.forename: S A
authors.initials: SA
authors.lastname: Sergeeva
authors.forename: O I
authors.initials: OI
authors.lastname: Epshtein
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000276:immunology / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D019808:Losartan / Q000627:therapeutic use; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011945:Receptors, Angiotensin / Q000276:immunology
chemical_list: D000906:Antibodies; D000959:Antihypertensive Agents; D011945:Receptors, Angiotensin; D019808:Losartan