Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice.
Compared with apoE3, apoE4 is associated with increased risk to develop age-related cognitive decline, particularly in women. In this study, young, middle-aged, and old female mice expressing human apoE under control of the mouse apoE promoter were behaviorally analyzed. Cognitive performance in the water maze decreased with age in all mice. Compared with apoE2 and apoE3 mice, apoE4 mice showed better cognitive performance and higher measures of anxiety than apoE2 and apoE3 mice. Measures of anxiety correlated with cognitive performance in the water maze and passive avoidance tests and might have contributed to the enhanced cognitive performance of the apoE4 mice. ApoE4 mice showed better water maze learning and higher cortical apoE levels than mice expressing apoE4 in astrocytes under control of the GFAP promoter. This was not seen in apoE3 mice. There were no line differences in either genotype in spatial memory retention in the probe trial following the last day of hidden platform training. Thus, the promoter used to express apoE4 critically modulates its effects on brain function.
Siegel
Jessica A
JA
Department of Behavioral Neuroscience, Oregon Health and Science University, 8131 SW Sam Jackson Park Road, Portland, OR 97239, USA.
Haley
Gwendolen E
GE
Raber
Jacob
J
D000375:Aging / Q000235:genetics*; D000818:Animals; D001007:Anxiety / Q000150:complications / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D001921:Brain / Q000503:physiopathology*; D003071:Cognition; D003072:Cognition Disorders / Q000150:complications / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D051379:Mice; D008822:Mice, Transgenic; D020033:Protein Isoforms
D001057:Apolipoproteins E; D020033:Protein Isoforms
J Neural Transm Suppl. 1996;47:205-18
8841967
Radiat Res. 2006 Dec;166(6):883-91
17149978
Neuropsychology. 2005 Mar;19(2):199-211
15769204
J Neuropathol Exp Neurol. 1994 Sep;53(5):429-37
8083686
J Neurosci. 1997 Jan 15;17(2):516-29
8987775
Neurobiol Aging. 2005 May;26(5):637-43
15708438
Neurobiol Learn Mem. 2009 Mar;91(3):260-5
19010430
J Neurol Neurosurg Psychiatry. 2007 Feb;78(2):123-6
16980336
Psychosomatics. 2004 Jan-Feb;45(1):49-57
14709760
Neurology. 2002 Apr 9;58(7):1115-8
11940706
Neuropsychopharmacology. 2004 Mar;29(3):441-9
14628000
Neuroscience. 2006;137(2):413-23
16330151
JAMA. 1997 Oct 22-29;278(16):1349-56
9343467
J Biol Chem. 1997 Jul 18;272(29):17972-80
9218423
J Neurol Neurosurg Psychiatry. 1996 Jun;60(6):644-9
8648331
Eur J Neurosci. 2004 Apr;19(7):1992-6
15078574
J Neurosci. 2005 Nov 16;25(46):10658-63
16291938
Lancet Neurol. 2007 Jun;6(6):494-500
17509484
Nature. 2000 Mar 23;404(6776):352-4
10746713
Mol Endocrinol. 1992 Feb;6(2):288-98
1373819
Pediatr Res. 2003 Dec;54(6):819-25
12930912
J Lipid Res. 1991 Oct;32(10):1611-8
1665849
Radiat Res. 2008 Oct;170(4):422-8
19024648
Science. 1988 Apr 29;240(4852):622-30
3283935
Biol Psychiatry. 1985 Jan;20(1):86-93
3965040
J Neurosci Methods. 1985 Aug;14(3):149-67
2864480
Brain Res. 2006 Feb 3;1071(1):113-23
16412995
J Neuropsychiatry Clin Neurosci. 2004 Summer;16(3):320-9
15377739
Neurobiol Learn Mem. 2003 Mar;79(2):194-8
12591227
Behav Brain Res. 2007 Jan 25;176(2):372-5
17126420
Radiats Biol Radioecol. 2008 Mar-Apr;48(2):167-70
18666648
Psychoneuroendocrinology. 2004 Aug;29(7):953-60
15177712
J Gerontol. 1991 Nov;46(6):P362-71
1940093
Neurology. 2002 Sep 10;59(5):746-8
12221169
J Biol Chem. 1997 Jun 13;272(24):15057-60
9182522
Neuroscience. 2004;124(4):725-33
15026113
Psychol Sci. 2006 Jun;17(6):466-70
16771794
Nature. 2002 Aug 29;418(6901):932
12198535
Psychol Med. 2000 Jan;30(1):11-22
10722172
Neuropsychology. 2005 Nov;19(6):830-40
16351359
Br J Psychiatry. 1991 Jan;158:64-71
2015452
Behav Neurosci. 1993 Aug;107(4):618-26
8397866
Ann Neurol. 1995 Jul;38(1):6-14
7611727
Alzheimer Dis Assoc Disord. 1994;8(Suppl. 1):S360-7
11657168
Pediatr Res. 2010 Mar;67(3):293-9
19952867
J Neuropsychiatry Clin Neurosci. 2003 Spring;15(2):180-6
12724459
J Neurosci. 2002 Jun 15;22(12):5204-9
12077215
Behav Brain Res. 2008 Nov 21;193(2):174-82
18572260
JAMA. 1982 Jul 16;248(3):333-5
7087127
Rev Neurol. 2004 May 16-31;38(10):901-5
15175968
Biol Psychiatry. 2002 Jan 1;51(1):11-7
11801227
Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10914-9
9724804
Annu Rev Neurosci. 1992;15:353-75
1575447
Biol Psychol. 2007 Jul;75(3):229-38
17433528
J Clin Invest. 1999 Jun;103(11):1579-86
10359567
Atherosclerosis. 1999 Dec;147(2):293-6
10559515
Mol Pathol. 2003 Jun;56(3):132-6
12782758
Childs Nerv Syst. 2008 Mar;24(3):349-56
17932679
Biol Psychiatry. 2002 Jan 1;51(1):68-80
11801232
Neurosci Lett. 2000 Nov 24;294(3):179-81
11072144
Behav Brain Res. 2006 Mar 15;168(1):92-9
16310870
J Neurosci. 2000 Mar 1;20(5):2064-71
10684907
Neuroscience. 2007 Jun 15;147(1):6-17
17509769
Sci Aging Knowledge Environ. 2004 Mar 17;2004(11):re2
15028864
Neurosci Lett. 2001 Feb 16;299(1-2):97-100
11166947
Neural Plast. 2007;2007:91236
17710250
Behav Neurosci. 2005 Apr;119(2):512-7
15839797
Behav Brain Res. 2005 Apr 15;159(1):1-14
15794991
Neurobiol Aging. 2005 Apr;26(4):475-84
15653176
Neurology. 1993 Aug;43(8):1467-72
8350998
Psychopharmacology (Berl). 1994 Sep;116(1):56-64
7862931