title: Maternal pesticide use and birth weight in the agricultural health study.
abstract: Studies examining the association between maternal pesticide exposure and low birth weight yield conflicting results. The authors examined the association between maternal pesticide use and birth weight among women in the Agricultural Health Study, a large study of pesticide applicators and their spouses in Iowa and North Carolina. The authors evaluated self-reported pesticide use of 27 individual pesticides in relation to birth weight among 2246 farm women whose most recent singleton birth occurred within 5 years of enrollment (1993-1997). The authors used linear regression models adjusted for site, preterm birth, medical parity, maternal body mass index, height, and smoking. The results showed that mean infant birth weight was 3586 g (+/- 546 g), and 3% of the infants were low birth weight (<2500 g). First-trimester pesticide-related tasks were not associated with birth weight. Ever use of the pesticide carbaryl was associated with decreased birth weight (-82 g, 95% confidence interval [CI] = -132, -31). This study thus provides limited evidence about pesticide use as a modulator of birth weight. Overall, the authors observed no associations between birth weight and pesticide-related activities during early pregnancy; however, the authors have no data on temporal specificity of individual pesticide exposures prior to or during pregnancy and therefore cannot draw conclusions related to these exposure windows. Given the widespread exposure to pesticide products, additional evaluation of maternal pregnancy exposures at specific time windows and subsequent birth outcomes is warranted.
authors.affiliation: Department of Pediatrics, University of Washington, Seattle, Washington 98101, USA. sheela.sathyanarayana@seattlechildrens.org
authors.forename: Sheela
authors.initials: S
authors.lastname: Sathyanarayana
authors.forename: Olga
authors.initials: O
authors.lastname: Basso
authors.forename: Catherine J
authors.initials: CJ
authors.lastname: Karr
authors.forename: Paula
authors.initials: P
authors.lastname: Lozano
authors.forename: Michael
authors.initials: M
authors.lastname: Alavanja
authors.forename: Dale P
authors.initials: DP
authors.lastname: Sandler
authors.forename: Jane A
authors.initials: JA
authors.lastname: Hoppin
mesh_terms: D000293:Adolescent; D000328:Adult; D000383:Agriculture; D012721:Carbaryl / Q000009:adverse effects*; D005260:Female; D006306:Health Surveys; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007306:Insecticides / Q000009:adverse effects*; D007484:Iowa; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects*; D008875:Middle Aged; D009035:Mothers; D009657:North Carolina; D016273:Occupational Exposure / Q000009:adverse effects*; D016272:Occupational Health; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000378:metabolism; D055815:Young Adult
chemical_list: D007306:Insecticides; D012721:Carbaryl
references.citation: Environ Health Perspect. 2004 Jul;112(10):1125-32
references.pmid: 15238288
references.citation: J Toxicol Environ Health. 1984;14(2-3):267-78
references.pmid: 6438344
references.citation: Diabetes Care. 2007 Mar;30(3):529-34
references.pmid: 17327316
references.citation: Semin Perinatol. 2004 Feb;28(1):41-50
references.pmid: 15058901
references.citation: Occup Environ Med. 2006 Jul;63(7):469-75
references.pmid: 16698811
references.citation: Environ Health Perspect. 2007 Nov;115(11):1677-82
references.pmid: 18008003
references.citation: Environ Res. 2002 Oct;90(2):89-97
references.pmid: 12483798
references.citation: Occup Med. 1993 Oct-Dec;8(4):869-82
references.pmid: 8303498
references.citation: Pediatr Res. 1998 Oct;44(4):538-45
references.pmid: 9773843
references.citation: Epidemiology. 2005 Sep;16(5):648-56
references.pmid: 16135941
references.citation: Ann Epidemiol. 2003 Mar;13(3):151-7
references.pmid: 12604157
references.citation: Environ Health Perspect. 1996 Apr;104(4):362-9
references.pmid: 8732939
references.citation: Am J Epidemiol. 1998 Jan 15;147(2):136-40
references.pmid: 9457002
references.citation: Occup Environ Med. 2005 Jun;62(6):400-5
references.pmid: 15901888
references.citation: Environ Health Perspect. 1997 Mar;105(3):308-14
references.pmid: 9171992
references.citation: Environ Health Perspect. 2003 Feb;111(2):201-5
references.pmid: 12573906
references.citation: Environ Res. 2007 Nov;105(3):307-15
references.pmid: 17659274
references.citation: Epidemiology. 2002 Jan;13(1):94-9
references.pmid: 11805592
references.citation: Environ Health Perspect. 2002 Dec;110(12):A787-92
references.pmid: 12460819
references.citation: Pediatr Res. 2007 Feb;61(2):243-50
references.pmid: 17237730
references.citation: Reprod Toxicol. 2008 Apr;25(3):316-26
references.pmid: 18434086
references.citation: Environ Health Perspect. 2002 May;110(5):549-53
references.pmid: 12003762
references.citation: Am J Epidemiol. 1997 Jan 1;145(1):58-67
references.pmid: 8982023
references.citation: Epidemiology. 2007 Jan;18(1):120-9
references.pmid: 17179760
references.citation: J Cell Physiol. 2007 Oct;213(1):177-86
references.pmid: 17503468
references.citation: Ecotoxicol Environ Saf. 2003 Mar;54(3):330-8
references.pmid: 12651189
references.citation: Environ Health Perspect. 2004 Jul;112(10):1116-24
references.pmid: 15238287
references.citation: J Occup Environ Hyg. 2005 Jul;2(7):357-67
references.pmid: 16020099