title: How the sequence of a gene can tune its translation.
abstract: Sixty-one codons specify 20 amino acids, offering cells many options for encoding a polypeptide sequence. Two new studies (Cannarrozzi et al., 2010; Tuller et al., 2010) now foster the idea that patterns of codon usage can control ribosome speed, fine-tuning translation to increase the efficiency of protein synthesis.
authors.affiliation: Department of Microbiology, Ohio State Biochemistry Program, and Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA. fredrick.5@osu.edu
authors.forename: Kurt
authors.initials: K
authors.lastname: Fredrick
authors.forename: Michael
authors.initials: M
authors.lastname: Ibba
mesh_terms: D001483:Base Sequence; D003062:Codon; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000502:physiology*
chemical_list: D003062:Codon
references.citation: Antonie Van Leeuwenhoek. 2008 Jun;94(1):111-26
references.pmid: 18320344
references.citation: J Biol Chem. 2009 May 15;284(20):13746-13754
references.pmid: 19289464
references.citation: Biochimie. 2010 Jan;92(1):12-20
references.pmid: 19835927
references.citation: Nature. 2009 May 7;459(7243):118-21
references.pmid: 19424157
references.citation: Mol Cell. 2008 Feb 29;29(4):419-27
references.pmid: 18313381
references.citation: Eur J Biochem. 1985 Mar 1;147(2):281-9
references.pmid: 3971983
references.citation: Science. 2009 Apr 10;324(5924):218-23
references.pmid: 19213877
references.citation: Science. 2009 Apr 10;324(5924):255-8
references.pmid: 19359587
references.citation: J Mol Biol. 2010 Feb 26;396(3):821-31
references.pmid: 20026070
references.citation: J Biol Chem. 2009 Sep 11;284(37):25254-67
references.pmid: 19546227
references.citation: J Mol Biol. 2010 Mar 12;396(5):1310-8
references.pmid: 20043920
references.citation: Nat Struct Mol Biol. 2009 Mar;16(3):274-80
references.pmid: 19198590
references.citation: J Cell Biol. 1984 Aug;99(2):373-7
references.pmid: 6746733
references.citation: Cell. 2010 Apr 16;141(2):355-67
references.pmid: 20403329
references.citation: Mol Cell. 2006 Apr 7;22(1):105-15
references.pmid: 16600874
references.citation: J Mol Biol. 2003 Aug 22;331(4):737-43
references.pmid: 12909006
references.citation: Science. 2003 Jun 13;300(5626):1718-22
references.pmid: 12805541
references.citation: EMBO Rep. 2005 Feb;6(2):151-7
references.pmid: 15678157
references.citation: Science. 2000 Aug 11;289(5481):905-20
references.pmid: 10937989