title: Lipid profiles and trans fatty acids in serum phospholipids of semi-nomadic Fulani in northern Nigeria.
abstract: The Fulani are semi-nomadic pastoralists of West Africa whose diet, culture, and economy are centred on cattle. Previous studies have shown that the Fulani of northern Nigeria derive 50% of their total calories from fat and 30% of their calories from milk, cheese, yogurt, and butter oil that contain significant amounts of trans fatty acids (TFAs), primarily vaccenic acid, which raise total serum cholesterol and low-density lipoproteincholesterol (LDL-C), and lower high-density lipoprotein-cholesterol (HDL-C). The study was conducted to know how the consumption of relatively large amounts of dairy products by adult Fulani affected the TFA content of their serum phospholipids. Blood samples were collected from 22 male and 29 female Fulani, aged 35-60 years, who were living in rural areas of Gombe state in northeastern Nigeria. The total serum phospholipid fraction was isolated, and its fatty acid composition was determined. Surprisingly, vaccenic acid was not detected, and three other TFAs--18:1-t6, 18:1-t9, and 18:2-t9,t12--together accounted for only 0.16% of the total fatty acid. The mean serum total cholesterol, LDL-C, and triglyceride concentrations of the subjects were within the normal range for populations in developed countries; however, at 32 mg/dL, the mean serum HDL-C concentration of the Fulani males was slightly below the lower limit of the reference range. No correlations were observed between the total TFA percentage or that of the three individual TFAs and any of the parameters of the serum lipid profile. These findings indicate that, with respect to TFAs at least, the fatty acid pattern of the serum phospholipids of Fulani pastoralists does not reflect the high TFA content of their traditional diet. Despite the consumption of rumenic acid-rich dairy products, for unknown reasons, the semi-nomadic Fulani manage to maintain a low level of TFAs in their blood and a relatively healthful serum lipid profile. While the mechanism that accounts for this disconnect between the consumption of TFAs by Fulani pastoralists and the proportion of TFAs in their serum phospholipids is obscure, possibilities include discrimination against rumenic acid during the process of triglyceride synthesis and chylomicron synthesis in the intestine and the preferential oxidation of TFAs by Fulani the people compared to other ethnic groups.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA.
authors.forename: Robert H
authors.initials: RH
authors.lastname: Glew
authors.forename: Lu-Te
authors.initials: LT
authors.lastname: Chuang
authors.forename: Tammy
authors.initials: T
authors.lastname: Berry
authors.forename: Henry
authors.initials: H
authors.lastname: Okolie
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Crossey
authors.forename: Dorothy J
authors.initials: DJ
authors.lastname: VanderJagt
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood*; D004032:Diet / Q000379:methods; D017097:Electric Impedance; D005260:Female; D006801:Humans; D044243:Linoleic Acids, Conjugated / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D009549:Nigeria; D010743:Phospholipids / Q000097:blood*; D012424:Rural Population / Q000706:statistics & numerical data; D012737:Sex Factors; D044242:Trans Fatty Acids / Q000097:blood*; D014171:Transients and Migrants / Q000706:statistics & numerical data*; D014280:Triglycerides / Q000097:blood*
chemical_list: D015415:Biomarkers; D044243:Linoleic Acids, Conjugated; D008055:Lipids; D010743:Phospholipids; D044242:Trans Fatty Acids; D014280:Triglycerides; C046938:9,11-linoleic acid; D002784:Cholesterol
references.citation: Clin Chim Acta. 2006 May;367(1-2):48-54
references.pmid: 16480970
references.citation: J Nutr. 2003 Mar;133 Suppl 3(3):925S-932S
references.pmid: 12612178
references.citation: J Nutr. 2005 Mar;135(3):562-6
references.pmid: 15735094
references.citation: Am J Clin Nutr. 2008 Apr;87(4):887-95
references.pmid: 18400711
references.citation: N Engl J Med. 2006 Apr 13;354(15):1601-13
references.pmid: 16611951
references.citation: Atherosclerosis. 1996 Sep 27;126(1):155-61
references.pmid: 8879443
references.citation: J Biol Chem. 1957 May;226(1):497-509
references.pmid: 13428781
references.citation: Am J Clin Nutr. 2008 Mar;87(3):558-66
references.pmid: 18326592
references.citation: Clin Chim Acta. 2006 Apr;366(1-2):130-6
references.pmid: 16413009
references.citation: Lipids. 2003 Jun;38(6):657-64
references.pmid: 12934676
references.citation: Br J Nutr. 2005 Apr;93(4):529-35
references.pmid: 15946416
references.citation: J Health Popul Nutr. 2004 Dec;22(4):357-69
references.pmid: 15663169
references.citation: Nutr Metab (Lond). 2005 Oct 10;2:26
references.pmid: 16216119
references.citation: Prostaglandins Leukot Essent Fatty Acids. 2003 Oct;69(4):245-52
references.pmid: 12907134
references.citation: Nutrition. 1996 Nov-Dec;12(11-12):749-62
references.pmid: 8974099
references.citation: Arch Intern Med. 2008 May 26;168(10):1055-62
references.pmid: 18504333
references.citation: Am J Clin Nutr. 2008 Mar;87(3):515-6
references.pmid: 18326587
references.citation: Am J Clin Nutr. 2009 Jan;89(1):331-46
references.pmid: 19056549
references.citation: Arch Dis Child. 2002 Sep;87(3):252-4
references.pmid: 12193445
references.citation: J Am Diet Assoc. 2008 Oct;108(10):1693-9
references.pmid: 18926136
references.citation: Curr Opin Clin Nutr Metab Care. 2005 May;8(3):311-7
references.pmid: 15809535
references.citation: Am J Clin Nutr. 2004 Dec;80(6):1521-5
references.pmid: 15585763
references.citation: Physiol Res. 2008;57 Suppl 1:S57-S65
references.pmid: 18271691
references.citation: J Lipid Res. 1992 Oct;33(10):1493-501
references.pmid: 1431574
references.citation: Am J Clin Nutr. 2008 Mar;87(3):593-9
references.pmid: 18326596
references.citation: Nutrition. 1999 Nov-Dec;15(11-12):874-80
references.pmid: 10575664
references.citation: Clin Chem. 1974 Apr;20(4):470-5
references.pmid: 4818200
references.citation: Am J Clin Nutr. 1995 Sep;62(3):572-8
references.pmid: 7661119
references.citation: Clin Nutr. 2004 Oct;23(5):1226-43
references.pmid: 15380917
references.citation: Am J Clin Nutr. 2001 Dec;74(6):730-6
references.pmid: 11722953
references.citation: Eur J Clin Nutr. 2000 May;54(5):367-72
references.pmid: 10822282
references.citation: J Trop Pediatr. 2000 Apr;46(2):67-72
references.pmid: 10822931
references.citation: J Natl Med Assoc. 2004 Jun;96(6):826-32
references.pmid: 15233494