title: Liver and brain imaging through dimercaptosuccinic acid-coated iron oxide nanoparticles.
abstract: OBJECTIVE
  Uptake, cytotoxicity and interaction of improved superparamagnetic iron oxide nanoparticles were studied in cells, tissues and organs after single and multiple exposures.
  
  
  METHODS
  We prepared dimercaptosuccinic acid-coated iron oxide nanoparticles by thermal decomposition in organic medium, resulting in aqueous suspensions with a small hydrodynamic size (< 100 nm), high saturation magnetization and susceptibility, high nuclear magnetic resonance contrast and low cytotoxicity.
  
  
  RESULTS
  In vitro and in vivo behavior showed that these nanoparticles are efficient carriers for drug delivery to the liver and brain that can be combined with MRI detection.
authors.affiliation: Centro Nacional de Biotecnología/CSIC, Spain.
authors.forename: Raquel
authors.initials: R
authors.lastname: Mejías
authors.forename: Sonia
authors.initials: S
authors.lastname: Pérez-Yagüe
authors.forename: Alejandro G
authors.initials: AG
authors.lastname: Roca
authors.forename: Nicolás
authors.initials: N
authors.lastname: Pérez
authors.forename: Angeles
authors.initials: A
authors.lastname: Villanueva
authors.forename: Magdalena
authors.initials: M
authors.lastname: Cañete
authors.forename: Santos
authors.initials: S
authors.lastname: Mañes
authors.forename: Jesús
authors.initials: J
authors.lastname: Ruiz-Cabello
authors.forename: Marina
authors.initials: M
authors.lastname: Benito
authors.forename: Amilcar
authors.initials: A
authors.lastname: Labarta
authors.forename: Xavier
authors.initials: X
authors.lastname: Batlle
authors.forename: Sabino
authors.initials: S
authors.lastname: Veintemillas-Verdaguer
authors.forename: M Puerto
authors.initials: MP
authors.lastname: Morales
authors.forename: Domingo F
authors.initials: DF
authors.lastname: Barber
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Serna
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D002470:Cell Survival; D005290:Ferric Compounds / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008099:Liver / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D051381:Rats; D004113:Succimer / Q000737:chemistry*
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide; D004113:Succimer