title: Treatment modalities in children with teeth affected by molar-incisor enamel hypomineralisation (MIH): A systematic review.
abstract: OBJECTIVE
  This was to review the literature concerning the treatment of permanent teeth with molar-incisor hypomineralised enamel (MIH), comment about possible shortcomings and propose areas of future research.
  
  
  METHODS
  A search of MedLine, Scopus, ResearchGate, Isis and Google Scholar databases was conducted using all terms relevant to the subject. Relevant papers published in English were identified after a review of their titles, abstracts or full reading of the papers.
  
  
  RESULTS
  Of 189 references initially found, 66 papers were included; 34 directly relevant to the subject. From the latter, only 14 concerned laboratory or clinical studies dealing with treatment for MIH. Since 2000 11 reviews evaluated, to a certain extent, treatment options for affected teeth. Analysis of the proposed treatment modalities indicated options for prevention, restorations, and adhesion to hypomineralised enamel, full coronal coverage and extraction followed by orthodontics. Based on these findings, a treatment decision plan is proposed.
  
  
  CONCLUSIONS
  Although treatment approaches for MIH have started to be clearer, long-term clinical trials, supported by laboratory studies, should be conducted to further facilitate the clinical management of this dental defect.
authors.affiliation: Dept of Paediatric Dentistry, Community Dental Centre for Children, Athens, Greece. lygidakis@ath.forthnet.gr
authors.forename: N A
authors.initials: NA
authors.lastname: Lygidakis
mesh_terms: D002364:Caseins / Q000627:therapeutic use; D002648:Child; D003442:Crowns; D003731:Dental Caries / Q000517:prevention & control; D003744:Dental Enamel Hypoplasia / Q000628:therapy*; D003793:Dental Restoration, Permanent / Q000379:methods; D019229:Dentition, Permanent; D005459:Fluorides / Q000627:therapeutic use; D006801:Humans; D010895:Pit and Fissure Sealants / Q000627:therapeutic use; D014089:Tooth Remineralization
chemical_list: D002364:Caseins; D010895:Pit and Fissure Sealants; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex; D005459:Fluorides
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