title: Behind the smile: cell biology and disease mechanisms of Giardia species.
abstract: The eukaryotic intestinal parasite Giardia intestinalis was first described in 1681, when Antonie van Leeuwenhoek undertook a microscopic examination of his own diarrhoeal stool. Nowadays, although G. intestinalis is recognized as a major worldwide contributor to diarrhoeal disease in humans and other mammals, the disease mechanisms are still poorly understood. Owing to its reduced complexity and proposed early evolutionary divergence, G. intestinalis is used as a model eukaryotic system for studying many basic cellular processes. In this Review we discuss recent discoveries in the molecular cell biology and pathogenesis of G. intestinalis.
authors.affiliation: Department of Cell and Molecular Biology, Biomedical Center, BOX 596, Uppsala University, SE-751 24 Uppsala, Sweden.
authors.forename: Johan
authors.initials: J
authors.lastname: Ankarklev
authors.forename: Jon
authors.initials: J
authors.lastname: Jerlström-Hultqvist
authors.forename: Emma
authors.initials: E
authors.lastname: Ringqvist
authors.forename: Karin
authors.initials: K
authors.lastname: Troell
authors.forename: Staffan G
authors.initials: SG
authors.lastname: Svärd
mesh_terms: D000818:Animals; D000940:Antigenic Variation; D003967:Diarrhea / Q000382:microbiology; D016829:Giardia lamblia / Q000166:cytology / Q000254:growth & development / Q000472:pathogenicity*; D005873:Giardiasis / Q000209:etiology / Q000469:parasitology; D006801:Humans; D008018:Life Cycle Stages; D010802:Phylogeny; D053058:Trophozoites / Q000166:cytology; D037521:Virulence Factors / Q000145:classification
chemical_list: D037521:Virulence Factors
references.citation: J Biol Chem. 2005 Aug 26;280(34):30557-63
references.pmid: 15985435
references.citation: Science. 2008 Mar 14;319(5869):1530-3
references.pmid: 18339940
references.citation: Infect Immun. 2007 Sep;75(9):4514-8
references.pmid: 17620354
references.citation: Cell Microbiol. 2001 Jan;3(1):55-62
references.pmid: 11207620
references.citation: FEMS Immunol Med Microbiol. 2007 Nov;51(2):302-9
references.pmid: 17714487
references.citation: Parasitol Res. 2004 Oct;94(4):254-264
references.pmid: 15349774
references.citation: J Biol Chem. 1995 Dec 8;270(49):29307-13
references.pmid: 7493963
references.citation: Int J Parasitol. 2008 Jul;38(8-9):923-34
references.pmid: 18281046
references.citation: Mol Biol Evol. 2006 Mar;23(3):615-25
references.pmid: 16308337
references.citation: Mol Microbiol. 2005 Nov;58(4):999-1011
references.pmid: 16262786
references.citation: Proc Natl Acad Sci U S A. 1990 Jun;87(12):4463-7
references.pmid: 2352929
references.citation: J Eukaryot Microbiol. 1996 Sep-Oct;43(5):416-29
references.pmid: 8822813
references.citation: Mem Inst Oswaldo Cruz. 2006 Sep;101(6):693-6
references.pmid: 17072486
references.citation: J Infect Dis. 1987 Dec;156(6):974-84
references.pmid: 3680997
references.citation: J Biol Chem. 2003 Jul 4;278(27):24837-48
references.pmid: 12711599
references.citation: J Biol Chem. 2008 Dec 19;283(51):35996-6010
references.pmid: 18930915
references.citation: Clin Microbiol Rev. 2001 Jul;14(3):447-75
references.pmid: 11432808
references.citation: Infect Immun. 2005 Dec;73(12):8204-8
references.pmid: 16299316
references.citation: J Cell Sci. 2008 Sep 1;121(Pt 17):2930-8
references.pmid: 18697833
references.citation: Am J Trop Med Hyg. 1977 Jan;26(1):23-30
references.pmid: 842783
references.citation: Science. 2007 Sep 28;317(5846):1921-6
references.pmid: 17901334
references.citation: Infect Immun. 2004 Jun;72(6):3536-42
references.pmid: 15155662
references.citation: Crit Rev Microbiol. 2002;28(2):123-47
references.pmid: 12109771
references.citation: Trends Parasitol. 2003 Oct;19(10):440-6
references.pmid: 14519581
references.citation: J Antimicrob Chemother. 2007 Aug;60(2):280-7
references.pmid: 17561498
references.citation: Science. 2006 Jul 21;313(5785):314-8
references.pmid: 16857931
references.citation: Exp Parasitol. 1986 Jun;61(3):379-89
references.pmid: 3709752
references.citation: Microbiology (Reading). 2004 May;150(Pt 5):1237-1243
references.pmid: 15133086
references.citation: Science. 2006 Jan 13;311(5758):195-8
references.pmid: 16410517
references.citation: Nature. 2003 Nov 13;426(6963):172-6
references.pmid: 14614504
references.citation: Science. 1989 Jan 6;243(4887):75-7
references.pmid: 2911720
references.citation: Gut. 2007 Mar;56(3):316-7
references.pmid: 17339241
references.citation: Cell. 1997 May 2;89(3):437-44
references.pmid: 9150143
references.citation: Am J Hyg. 1954 Mar;59(2):209-20
references.pmid: 13138586
references.citation: PLoS Pathog. 2008 Dec;4(12):e1000243
references.pmid: 19096520
references.citation: J Cell Sci. 2006 Dec 1;119(Pt 23):4889-900
references.pmid: 17105767
references.citation: J Cell Sci. 1990 Mar;95 ( Pt 3):353-60
references.pmid: 2384520
references.citation: J Biol Chem. 2008 Nov 7;283(45):31021-9
references.pmid: 18768462
references.citation: Mol Microbiol. 2002 Aug;45(3):585-90
references.pmid: 12139606
references.citation: Nature. 2008 Dec 11;456(7223):750-4
references.pmid: 19079052
references.citation: BMC Gastroenterol. 2009 Apr 21;9:27
references.pmid: 19383162
references.citation: Trends Parasitol. 2009 Feb;25(2):93-100
references.pmid: 19135417
references.citation: J Biol Chem. 2009 Jul 3;284(27):17975-88
references.pmid: 19423705
references.citation: Scand J Gastroenterol. 1997 Jan;32(1):48-51
references.pmid: 9018766
references.citation: Gastroenterology. 2002 Oct;123(4):1179-90
references.pmid: 12360480
references.citation: J Infect Dis. 2001 Jan 1;183(1):119-24
references.pmid: 11087204
references.citation: Curr Biol. 2005 Jan 26;15(2):185-91
references.pmid: 15668177
references.citation: Mol Biochem Parasitol. 2008 Aug;160(2):75-80
references.pmid: 18501440
references.citation: Curr Opin Microbiol. 2007 Dec;10(6):560-8
references.pmid: 18024150
references.citation: Curr Biol. 2007 Nov 20;17(22):1984-8
references.pmid: 17980591
references.citation: J Cell Sci. 2009 Aug 15;122(Pt 16):2846-56
references.pmid: 19622633
references.citation: Mol Biochem Parasitol. 2006 Mar;146(1):45-57
references.pmid: 16310259
references.citation: Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10924-9
references.pmid: 16040811
references.citation: Infect Immun. 2006 Apr;74(4):2473-6
references.pmid: 16552082
references.citation: Eukaryot Cell. 2009 Oct;8(10):1584-91
references.pmid: 19717741
references.citation: Int J Parasitol. 2003 Sep 15;33(10):1005-12
references.pmid: 13129521
references.citation: Parasitol Res. 2007 May;100(6):1169-75
references.pmid: 17252271
references.citation: Mol Biol Evol. 2009 Sep;26(9):1941-7
references.pmid: 19531743
references.citation: J Biol Chem. 2007 Mar 23;282(12):8905-14
references.pmid: 17244608
references.citation: Int J Parasitol. 2008 Jul;38(8-9):935-44
references.pmid: 18289546
references.citation: J Biol Chem. 2006 Mar 17;281(11):7595-604
references.pmid: 16407213
references.citation: Curr Opin Microbiol. 2007 Dec;10(6):554-9
references.pmid: 17981075
references.citation: Mol Biochem Parasitol. 2005 Jun;141(2):199-207
references.pmid: 15850703
references.citation: Curr Biol. 2008 Jan 22;18(2):R66-8
references.pmid: 18211841
references.citation: Int J Syst Evol Microbiol. 2003 Nov;53(Pt 6):1759-77
references.pmid: 14657103
references.citation: Gastroenterology. 1995 Sep;109(3):766-73
references.pmid: 7657104
references.citation: Cell Microbiol. 2009 Dec;11(12):1706-15
references.pmid: 19709056
references.citation: Mol Microbiol. 2002 Nov;46(4):971-84
references.pmid: 12421304
references.citation: Mol Microbiol. 1995 Mar;15(5):955-63
references.pmid: 7596296
references.citation: Infect Immun. 1989 Mar;57(3):963-8
references.pmid: 2917795
references.citation: J Biol Chem. 2002 Mar 8;277(10):8474-81
references.pmid: 11773053
references.citation: Exp Parasitol. 1990 Nov;71(4):415-21
references.pmid: 1699782
references.citation: J Biol Chem. 2003 Jun 13;278(24):21701-8
references.pmid: 12686559
references.citation: J Biol Chem. 2002 Dec 27;277(52):50557-63
references.pmid: 12354777
references.citation: Chromosoma. 2007 Feb;116(1):65-78
references.pmid: 17086421
references.citation: PLoS Pathog. 2008 Nov;4(11):e1000224
references.pmid: 19043559
references.citation: Mol Biochem Parasitol. 2008 Jun;159(2):85-91
references.pmid: 18359106
references.citation: Int J Parasitol. 2008 Sep;38(11):1297-304
references.pmid: 18625508
references.citation: Mol Microbiol. 2006 Sep;61(6):1533-42
references.pmid: 16968226
references.citation: J Exp Med. 1988 Jan 1;167(1):109-18
references.pmid: 3335828
references.citation: Mol Biochem Parasitol. 2007 Mar;152(1):80-9
references.pmid: 17204341
references.citation: PLoS One. 2007 May 30;2(5):e488
references.pmid: 17534438
references.citation: J Cell Physiol. 2009 Oct;221(1):10-7
references.pmid: 19562686
references.citation: J Biol Chem. 1999 Oct 15;274(42):29805-11
references.pmid: 10514458
references.citation: Acta Trop. 2008 Apr;106(1):44-53
references.pmid: 18325480
references.citation: FEMS Microbiol Lett. 2003 Jan 21;218(1):3-7
references.pmid: 12583890
references.citation: PLoS One. 2006 Dec 20;1:e44
references.pmid: 17183673
references.citation: Int J Parasitol. 2001 Jan;31(1):73-9
references.pmid: 11165274
references.citation: Clin Infect Dis. 1997 Sep;25(3):545-9; quiz 550
references.pmid: 9314441
references.citation: Infect Immun. 1994 Aug;62(8):3583-5
references.pmid: 8039934
references.citation: BMC Genomics. 2007 Feb 14;8:51
references.pmid: 17298675
references.citation: J Pediatr Gastroenterol Nutr. 1997 Jan;24(1):79-88
references.pmid: 9093992
references.citation: Traffic. 2008 Jan;9(1):57-71
references.pmid: 17892527
references.citation: Mol Biochem Parasitol. 2000 Jun;109(1):61-5
references.pmid: 10924757
references.citation: Trends Parasitol. 2006 Jan;22(1):26-31
references.pmid: 16303332
references.citation: J Parasitol. 2000 Aug;86(4):800-6
references.pmid: 10958459
references.citation: Mol Microbiol. 1998 Dec;30(5):979-89
references.pmid: 9988475
references.citation: PLoS Pathog. 2009 Aug;5(8):e1000560
references.pmid: 19696920
references.citation: Int J Parasitol. 2005 May;35(6):617-26
references.pmid: 15862575
references.citation: Parasitology. 2002 Jul;125(Pt 1):11-9
references.pmid: 12166516
references.citation: Eukaryot Cell. 2002 Apr;1(2):191-9
references.pmid: 12455954
references.citation: PLoS One. 2007 Aug 06;3(8):e2879
references.pmid: 18663385
references.citation: Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):229-34
references.pmid: 9419358
references.citation: Exp Parasitol. 1998 Mar;88(3):172-83
references.pmid: 9562420
references.citation: J Eukaryot Microbiol. 2005 Sep-Oct;52(5):399-451
references.pmid: 16248873
references.citation: Mol Microbiol. 1999 Oct;34(2):327-40
references.pmid: 10564476
references.citation: J Biol Chem. 2003 Jan 24;278(4):2533-40
references.pmid: 12397071
references.citation: Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3701-5
references.pmid: 11854456
references.citation: Mol Biochem Parasitol. 2002 Jun;122(1):95-8
references.pmid: 12076774
references.citation: J Parasitol. 1998 Apr;84(2):222-6
references.pmid: 9576491
references.citation: Gut. 2007 Mar;56(3):328-35
references.pmid: 16935925
references.citation: Int J Parasitol. 2003 Jan;33(1):3-28
references.pmid: 12547343
references.citation: Infect Immun. 1988 Jun;56(6):1420-3
references.pmid: 3372015
references.citation: Glycobiology. 2002 Aug;12(8):499-505
references.pmid: 12145190
references.citation: J Biol Chem. 2008 Jun 27;283(26):18024-31
references.pmid: 18445589
references.citation: J Parasitol. 1987 Jun;73(3):487-93
references.pmid: 3598798
references.citation: J Biol Chem. 2001 Mar 30;276(13):10320-9
references.pmid: 11104758
references.citation: Infect Immun. 2002 Jul;70(7):3673-80
references.pmid: 12065509
references.citation: Gastroenterology. 1992 Aug;103(2):506-13
references.pmid: 1634068
references.citation: Int J Parasitol. 2003 Oct;33(12):1341-51
references.pmid: 14527517