Is neonatal antiretroviral therapy a risk factor for NEC occurrence?
An association between maternal human immunodeficiency virus (HIV) infection and increased necrotizing enterocolitis (NEC) risk has been reported. Viral exposure and maternal antiretroviral therapy have been described as mediators of this risk. We report a preterm patient with delayed meconium passage and subsequent NEC, in which both the above-mentioned mechanisms were excluded, suggesting that neonatal antiretroviral therapy could be the most relevant risk factor for NEC in a susceptible preterm gut.
De Carolis
Maria Pia
MP
Division of Neonatology, Department of Pediatrics, University Hospital "A. Gemelli" Catholic University of the Sacred Heart, Rome, Italy.
Lacerenza
Serafina
S
De Luca
Daniele
D
Bersani
Iliana
I
Costa
Simonetta
S
Romagnoli
Costantino
C
D019380:Anti-HIV Agents / Q000009:adverse effects; D020345:Enterocolitis, Necrotizing / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000139:chemically induced* / Q000453:epidemiology / Q000503:physiopathology; D010528:Peristalsis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D012307:Risk Factors; D015215:Zidovudine / Q000009:adverse effects
D019380:Anti-HIV Agents; D015215:Zidovudine