title: Pregnancy complication and outcome in women with history of allergy to medicinal agents.
abstract: OBJECTIVE
  Pregnancy outcome in women with a previous history of drug allergy and the role of drug allergies in adverse pregnancy outcomes is unclear.
  
  
  METHODS
  A retrospective cohort study comparing pregnancies of women with and without history of drug allergy was conducted. Data were collected from the computerized perinatal database. A multiple logistic regression model, with background elimination, was constructed to control for confounders.
  
  
  RESULTS
  Of 186,443 deliveries, 4.6% (n = 8647) occurred in patients with a history of drug allergy. The following conditions were significantly associated with a history of drug allergy: advanced maternal age, recurrent abortions, fertility treatments, hypertensive disorders, and diabetes mellitus. Using multivariate analysis, with background elimination, history of drug allergy was significantly associated with intrauterine growth restriction (OR = 1.52, CI = 1.3-0.8, P < 0.001) and with preterm delivery (OR = 1.26, CI = 1.14-1.38, P < 0.001).
  
  
  CONCLUSIONS
  A history of drug allergy is an independent risk factor for intrauterine growth restriction and preterm delivery. Further prospective studies are needed to investigate the nature of this association.
authors.affiliation: Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: Iris
authors.initials: I
authors.lastname: Ohel
authors.forename: Amalia
authors.initials: A
authors.lastname: Levy
authors.forename: Aya
authors.initials: A
authors.lastname: Zweig
authors.forename: Gershon
authors.initials: G
authors.lastname: Holcberg
authors.forename: Eyal
authors.initials: E
authors.lastname: Sheiner
mesh_terms: D000328:Adult; D015331:Cohort Studies; D016208:Databases, Factual; D004342:Drug Hypersensitivity / Q000150:complications*; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D016015:Logistic Models; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000276:immunology*; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology / Q000276:immunology; D012189:Retrospective Studies; D012307:Risk Factors