Neuroimaging and neuropsychological follow-up study in a pediatric brain tumor patient treated with surgery and radiation.
Intracranial tumors are the most common neoplasms of childhood, accounting for approximately 20% of all pediatric malignancies. Radiation therapy has led directly to significant increases in survival of children with certain types of intracranial tumors; however, given the aggressive nature of this therapy, children are at risk for exhibiting changes in brain structure, neuronal biochemistry, and neurocognitive functioning. In this case report, we present neuropsychological, magnetic resonance imaging, proton magnetic resonance spectroscopic imaging, and diffusion tensor imaging data for two adolescents (one patient with ependymal spinal cord tumor with intracranial metastases, and one healthy, typically developing control) from three time points as defined by the patient's radiation schedule (baseline before the patient's radiation therapy, 6 months following completion of the patient's radiation, and 27 months following the patient's radiation). In the patient, there were progressive decreases in gray and white matter volumes as well as early decreases in mean N-acetyl aspartate/choline (NAA/Cho) ratios and fractional anisotropy (FA) in regions with normal appearance on conventional MRI. At the last follow-up, NAA/Cho and FA tended to change in the direction to normal values in selected regions. At the same time, the patient had initial reduction in language and motor skills, followed by return to baseline, but later onset delay in visuospatial and visual perceptual skills. Results are discussed in terms of sensitivity of the four techniques to early and late effects of treatment, and avenues for future investigations.
Schmidt
Adam T
AT
Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX, USA.
Martin
Rebecca B
RB
Ozturk
Arzu
A
Kates
Wendy R
WR
Wharam
Moody D
MD
Mahone
E Mark
EM
Horska
Alena
A
D000293:Adolescent; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001931:Brain Mapping; D003071:Cognition / Q000502:physiology*; D004806:Ependymoma / Q000601:surgery*; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007802:Language; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008297:Male; D008568:Memory / Q000502:physiology; D009483:Neuropsychological Tests; D010372:Pediatrics; D061766:Proton Therapy; D011597:Psychomotor Performance / Q000502:physiology; D016634:Radiosurgery / Q000379:methods*; D013125:Spinal Neoplasms / Q000601:surgery*; D014796:Visual Perception / Q000502:physiology
D001224:Aspartic Acid; C000179:N-acetylaspartate
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