An unprecedented method for the generation of tert-butylperoxy radical using DIB/TBHP protocol: solvent effect and application on allylic oxidation.
tert-Butylperoxy radical was generated with PhI(OAc)(2) and tBuOOH. Ester solvent was found to be critical and the protocol was applied in the allylic oxidation of various olefinic substrates, which gave the corresponding alpha,beta-unsaturated enones in good yield and regioselectivity.
Zhao
Yi
Y
Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
Yeung
Ying-Yeung
YY