Evaluation of regional cerebral blood flow in a patient with musical hallucinations.
A 52-year-old woman with musical hallucinations was examined using brain single photon emission computed tomography (SPECT) with 99mTc-ECD. Changes in regional cerebral blood flow (rCBF) after carbamazepine treatment were assessed using a three-dimensional stereotaxic ROI template. Following treatment, rCBF was decreased in the subcortical structures and increased in the global cortical regions. From our findings, we propose that rCBF values in subcortical structures represent abnormalities similar to those reported in previous reports or other psychiatric disorders, while those in cortical regions suggest background brain dysfunctions that result in generation of musical hallucinations.
Shoyama
Masaru
M
Department of Neuropsychiatry, Wakayama Medical University, Wakayama, Japan. shouyama@wakayama-med.ac.jp
Ukai
Satoshi
S
Kitabata
Yuji
Y
Yamamoto
Masahiro
M
Okumura
Masatoshi
M
Kose
Asami
A
Tsuji
Tomikimi
T
Shinosaki
Kazuhiro
K
D001299:Audiometry / Q000379:methods; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000098:blood supply* / Q000000981:diagnostic imaging; D005260:Female; D006212:Hallucinations / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D009146:Music; D012039:Regional Blood Flow / Q000502:physiology; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods