title: Two new xanthones from Artocarpus obtusus.
abstract: Two new xanthones, pyranocycloartobiloxanthone A (1) and dihydroartoindonesianin C (2), were isolated from the stem bark of Artocarpus obtusus Jarrett by chromatographic separation. Their structures were determined by using spectroscopic methods and comparison with known related compounds. Pyranocycloartobiloxanthone A (1) showed strong free radical scavenging activity by using DPPH assay as well as cytotoxicity towards K562, HL-60, and MCF7 cell lines.
authors.affiliation: Department of Chemistry, Universiti Putra Malaysia 43400 UPM, Selangor, Malaysia.
authors.forename: Najihah
authors.initials: N
authors.lastname: Hashim
authors.forename: Mawardi
authors.initials: M
authors.lastname: Rahmani
authors.forename: Mohd A
authors.initials: MA
authors.lastname: Sukari
authors.forename: Abdul M
authors.initials: AM
authors.lastname: Ali
authors.forename: Noorjahan B
authors.initials: NB
authors.lastname: Alitheen
authors.forename: Rosea
authors.initials: R
authors.lastname: Go
authors.forename: Hazar B M
authors.initials: HB
authors.lastname: Ismail
mesh_terms: D031622:Artocarpus / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008296:Malaysia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010851:Picrates / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D044004:Xanthones; C549170:dihydroartoindonesianin C; C549169:pyranocycloartobiloxanthone A; C004931:1,1-diphenyl-2-picrylhydrazyl