Metabolic fate of phenothiazine in the marmoset (Callithrix jacchus).
The fate of [35S]-phenothiazine, a veterinary anthelmintic, has been investigated in the adult male marmoset (Callithrix jacchus) following oral administration. A near complete recovery of radioactivity (c. 95%) was achieved in 0-3 days, with just over one-third of the dose (c. 37%) being present in the urine and the remainder (c. 58%) being accounted for in the faeces. The majority of the urinary radioactivity (c. 91%) was present as conjugates, tentatively identified as phenothiazine N-glucuronide and leucophenothiazone sulphate. Smaller amounts of phenothiazone, thionol, phenothiazine sulphoxide and unchanged phenothiazine were also identified. The only compound identified in the faeces was unchanged phenothiazine.
Mitchell
Stephen
S
Department of Biomolecular Medicine, SORA Division, Faculty of Medicine, Imperial College London, South Kensington, UK. s.c.mitchell@imperial.ac.uk
Steventon
Glyn
G
Waring
Rosemary
R
D000818:Animals; D000871:Anthelmintics / Q000493:pharmacokinetics* / Q000652:urine; D001711:Biotransformation; D002144:Callithrix / Q000378:metabolism* / Q000652:urine; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002855:Chromatography, Thin Layer / Q000379:methods; D005243:Feces / Q000737:chemistry; D008297:Male; D010640:Phenothiazines / Q000493:pharmacokinetics* / Q000652:urine
D000871:Anthelmintics; D010640:Phenothiazines; C031637:phenothiazine