Animal models in bariatric surgery--a review of the surgical techniques and postsurgical physiology.
Bariatric surgery is considered the most effective current treatment for morbid obesity. Since the first publication of an article by Kremen, Linner, and Nelson, many experiments have been performed using animal models. The initial experiments used only malabsorptive procedures like intestinal bypass which have largely been abandoned now. These experimental models have been used to assess feasibility and safety as well as to refine techniques particular to each procedure. We will discuss the surgical techniques and the postsurgical physiology of the four major current bariatric procedures (namely, Roux-en-Y gastric bypass, gastric banding, sleeve gastrectomy, and biliopancreatic diversion). We have also reviewed the anatomy and physiology of animal models. We have reviewed the literature and presented it such that it would be a reference to an investigator interested in animal experiments in bariatric surgery. Experimental animal models are further divided into two categories: large mammals that include dogs, cats, rabbits, and pig and small mammals that include rats and mice.
Rao
Raghavendra S
RS
Department Surgery, Mount Sinai School of Medicine, 5 E 98th Street, New York, NY 10029, USA. raghavendra.rao@mountsinai.org
Rao
Venkatesh
V
Kini
Subhash
S
D000818:Animals; D050110:Bariatric Surgery / Q000379:methods*; D015904:Biliopancreatic Diversion / Q000379:methods; D002415:Cats; D004285:Dogs; D005743:Gastrectomy / Q000379:methods; D015390:Gastric Bypass / Q000379:methods; D041981:Gastrointestinal Tract / Q000033:anatomy & histology / Q000502:physiology; D015391:Gastroplasty / Q000379:methods; D051379:Mice; D023421:Models, Animal; D011817:Rabbits; D051381:Rats; D034421:Sus scrofa
Surg Laparosc Endosc. 1997 Aug;7(4):294-7
9282759
J Am Coll Surg. 2004 Dec;199(6):887-95
15555972
Pediatr Surg Int. 2007 Jul;23(7):653-7
17505835
Metabolism. 1998 Dec;47(12):1494-8
9867080
Int J Obes. 1991 Jan;15(1):51-8
2010258
Am J Surg. 2007 Aug;194(2):221-4
17618808
J Laparoendosc Adv Surg Tech A. 2001 Apr;11(2):79-83
11327131
Microsurgery. 2008;28(3):197-202
18286660
Obes Surg. 2001 Feb;11(1):46-53
11361168
Obes Surg. 2006 May;16(5):597-602
16687028
Nutrition. 2008 Sep;24(9):832-42
18725080
Surgery. 2007 Jul;142(1):74-85
17630003
Obes Surg. 2007 Jun;17(6):815-9
17879583
Exp Physiol. 2007 Mar;92(2):399-408
17170058
Obes Surg. 2007 Dec;17(12):1599-607
18049841
Surgery. 2004 Aug;136(2):246-52
15300187
J Surg Res. 2002 Sep;107(1):56-63
12384065
Diabetes. 1994 May;43(5):640-4
8168639
Obes Surg. 2007 Sep;17(9):1193-8
18074494
Diabetes. 1998 Mar;47(3):358-64
9519740
Diabetologia. 1998 Nov;41(11):1374-80
9833947
Cell Metab. 2008 Sep;8(3):201-11
18762021
Obes Surg. 2008 Oct;18(10):1246-50
18581193
Phytother Res. 2003 Jun;17(6):591-8
12820223
Arq Gastroenterol. 2007 Apr-Jun;44(2):162-7
17962864
Obes Surg. 2007 Oct;17(10):1332-9
18098400
Cytokine. 2009 Jan;45(1):12-9
19026557
J Pediatr Surg. 1990 Mar;25(3):315-8
2313500
Surg Endosc. 2008 Apr;22(4):1029-34
18270777
J Gastrointest Surg. 2004 Jul-Aug;8(5):621-30
15240001
Obes Surg. 2009 Mar;19(3):357-62
18841429
Am J Physiol. 1996 Oct;271(4 Pt 1):E755-62
8897865
J Surg Res. 2009 Dec;157(2):243-50
19394650
Diabetes. 2001 Feb;50 Suppl 1:S89-93
11272210
World J Surg. 1998 Sep;22(9):955-63
9717421
Obes Surg. 2008 Oct;18(10):1263-7
18563496
Obes Surg. 2008 Jun;18(6):686-9
18322763
Atherosclerosis. 2000 Feb;148(2):231-41
10657558
Am J Surg. 1985 Feb;149(2):228-31
3970321
J Surg Res. 1987 Sep;43(3):264-70
3626545
Surgery. 2003 Aug;134(2):329-35
12947337
J Pharm Pharmacol. 2009 Apr;61(4):517-25
19298700
Br J Surg. 1979 Sep;66(9):613-7
497644
Obes Surg. 2009 Jul;19(7):921-5
18712452
Surgery. 2005 Aug;138(2):283-90
16153438
Endocrinology. 2005 Mar;146(3):1576-87
15591151
Am J Physiol Regul Integr Comp Physiol. 2007 Oct;293(4):R1474-89
17626126
Int J Obes (Lond). 2006 Mar;30(3):419-29
16302016
Diabetologia. 1999 Apr;42(4):427-34
10230646
Am J Surg. 1985 Mar;149(3):351-6
3976990
Diabetes. 2001 Nov;50(11):2521-9
11679430
Obes Surg. 2008 Jan;18(1):97-108
18066699
Am J Physiol. 1986 Mar;250(3 Pt 1):G287-94
3953815
Obes Surg. 2009 May;19(5):625-31
18972172
J Nippon Med Sch. 2008 Aug;75(4):202-6
18781041
Ann Surg. 2009 Feb;249(2):277-85
19212182
PLoS One. 2009;4(4):e5370
19401758
J Gastrointest Surg. 2006 Dec;10(10):1384-91
17175458
Int J Obes. 1989;13(2):147-54
2663746
Eur Surg Res. 2008;40(3):279-88
18253047
Cir Esp. 2008 Feb;83(2):89-92
18261415
Nutrition. 2004 Feb;20(2):218-24
14962690
Obes Surg. 2009 Apr;19(4):484-9
18855085
Obes Surg. 2006 Jan;16(1):48-51
16417758
Endocrinology. 2005 Apr;146(4):1745-51
15625244
Am J Physiol Endocrinol Metab. 2002 Mar;282(3):E626-33
11832366
Obes Res. 2005 Jan;13(1):3-10
15761158