title: Periodic heart rate decelerations in premature infants.
abstract: The pacemaking system of the heart is complex; a healthy heart constantly integrates and responds to extracardiac signals, resulting in highly complex heart rate patterns with a great deal of variability. In the laboratory and in some pathological or age-related states, however, dynamics can show reduced complexity that is more readily described and modeled. Reduced heart rate complexity has both clinical and dynamical significance - it may provide warning of impending illness or clues about the dynamics of the heart's pacemaking system. In this paper, we describe simple and interesting heart rate dynamics that we have observed in premature human infants - reversible transitions to large-amplitude periodic oscillations - and we show that the appearance and disappearance of these periodic oscillations can be described by a simple mathematical model, a Hopf bifurcation.
authors.affiliation: Structural, Computational Biology and Biophysics Program, University of Virginia, Charlottesville, VA 22903, USA.
authors.forename: Abigail A
authors.initials: AA
authors.lastname: Flower
authors.forename: J Randall
authors.initials: JR
authors.lastname: Moorman
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Lake
authors.forename: John B
authors.initials: JB
authors.lastname: Delos
mesh_terms: D001683:Biological Clocks / Q000502:physiology; D003654:Deceleration; D006329:Heart Conduction System / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008955:Models, Cardiovascular; D010507:Periodicity
references.citation: Sci Am. 1990 Feb;262(2):42-9
references.pmid: 2296715
references.citation: Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Jun;71(6 Pt 1):061917
references.pmid: 16089775
references.citation: Pediatr Res. 2007 Feb;61(2):222-7
references.pmid: 17237726
references.citation: Chaos. 2009 Jun;19(2):028501
references.pmid: 19566276
references.citation: Pediatr Res. 2003 Jun;53(6):920-6
references.pmid: 12646726
references.citation: Am J Physiol. 1987 Sep;253(3 Pt 2):H680-9
references.pmid: 3631301
references.citation: Proc Natl Acad Sci U S A. 2002 Feb 19;99 Suppl 1:2466-72
references.pmid: 11875196
references.citation: Science. 1999 Apr 2;284(5411):87-9
references.pmid: 10102823
references.citation: J Math Biol. 1997 Nov;36(1):41-63
references.pmid: 9440304
references.citation: Cardiovasc Res. 2006 Apr 1;70(1):12-21
references.pmid: 16360130
references.citation: Neurobiol Aging. 2002 Jan-Feb;23(1):23-6
references.pmid: 11755014
references.citation: Phys Rev E Stat Nonlin Soft Matter Phys. 2002 May;65(5 Pt 1):051923
references.pmid: 12059609
references.citation: Science. 2000 Nov 17;290(5495):1358-60
references.pmid: 11082063
references.citation: Pediatrics. 2005 Apr;115(4):937-41
references.pmid: 15805367
references.citation: Phys Rev E Stat Nonlin Soft Matter Phys. 2003 May;67(5 Pt 2):056216
references.pmid: 12786259
references.citation: Nature. 1996 Sep 26;383(6598):323-7
references.pmid: 8848043
references.citation: Phys Rev E Stat Nonlin Soft Matter Phys. 2006 May;73(5 Pt 1):052902
references.pmid: 16802980
references.citation: Science. 1981 Dec 18;214(4527):1350-3
references.pmid: 7313693
references.citation: Circulation. 1999 Mar 23;99(11):1435-40
references.pmid: 10086966
references.citation: Pediatrics. 2005 Nov;116(5):1070-4
references.pmid: 16263991
references.citation: Phys Rev E Stat Nonlin Soft Matter Phys. 2003 Mar;67(3 Pt 1):031914
references.pmid: 12689108
references.citation: Phys Rev E Stat Nonlin Soft Matter Phys. 2006 Apr;73(4 Pt 1):041907
references.pmid: 16711836
references.citation: Am J Respir Crit Care Med. 2001 May;163(6):1289-90
references.pmid: 11371381
references.citation: Pediatr Res. 2003 Jan;53(1):89-97
references.pmid: 12508086
references.citation: Curr Opin Crit Care. 2002 Aug;8(4):311-5
references.pmid: 12386491
references.citation: IEEE Trans Biomed Eng. 2006 Jan;53(1):126-32
references.pmid: 16402612
references.citation: Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Aug;66(2 Pt 2):026702
references.pmid: 12241313
references.citation: Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Jun;77(6 Pt 1):061921
references.pmid: 18643314
references.citation: Phys Rev Lett. 2004 May 14;92(19):198105
references.pmid: 15169451
references.citation: Pediatr Res. 2004 Feb;55(2):220-3
references.pmid: 14630986
references.citation: Pediatr Res. 2003 Jun;53(6):889-90
references.pmid: 12646723
references.citation: Phys Rev A Gen Phys. 1985 Feb;31(2):1077-1084
references.pmid: 9895588
references.citation: Curr Opin Crit Care. 2004 Oct;10(5):378-82
references.pmid: 15385755
references.citation: Methods Inf Med. 2000 Jun;39(2):118-21
references.pmid: 10892243
references.citation: Pediatrics. 2001 Jan;107(1):97-104
references.pmid: 11134441
references.citation: Phys Rev A Gen Phys. 1985 Sep;32(3):1744-1751
references.pmid: 9896261