title: Effectiveness and safety of balloon dilation of native aortic coarctation in premature neonates weighing < or = 2,500 grams.
abstract: Six neonates weighing < or = 2,500 g with native coarctation of the aorta underwent balloon dilation. Of the 6 neonates, 4 were female and 2 were male, with a mean age of 14 days (range 9 to 20) and a mean weight of 1,900 g (range 790 to 2,500). The procedure was acutely successful in all 6 patients; the peak gradient decreased from 38 + or - 19 mm Hg to 11 + or - 3 mm Hg. The diameter increased from 1.5 + or - 0.6 mm to 3.6 + or - 0.7 mm. Of the 6 patients, 3 had required no additional intervention at a mean of 42 months after the initial dilation, and 3 had developed restenosis a mean of 2.4 months after the initial dilation and underwent successful redilation. Of the latter 3 patients, 2 developed restenosis and underwent surgical repair 37 and 68 days after the second dilation, and 1 of these patients developed recoarctation after surgery that was treated successfully with balloon dilation 54 days after the end-to-end repair. In conclusion, premature neonates weighing < or = 2,500 g with coarctation of the aorta appear to respond acutely to balloon dilation. Some patients will have a successful long-term result after a single balloon dilation procedure. However, restenosis is common and tends to develop rapidly.
authors.affiliation: Children's Heart Center Nevada, Las Vegas, Nevada, USA. rothman@childrensheartcenter.com
authors.forename: Abraham
authors.initials: A
authors.lastname: Rothman
authors.forename: Alvaro
authors.initials: A
authors.lastname: Galindo
authors.forename: William N
authors.initials: WN
authors.lastname: Evans
authors.forename: Juan C
authors.initials: JC
authors.lastname: Collazos
authors.forename: Humberto
authors.initials: H
authors.lastname: Restrepo
mesh_terms: D000792:Angiography; D000800:Angioplasty, Balloon / Q000379:methods*; D001017:Aortic Coarctation / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy*; D001835:Body Weight; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome