title: Cancer prevention by bovine lactoferrin: from animal studies to human trial.
abstract: Colorectal cancer (CRC) is one of the most frequently diagnosed cancers and, despite improved colonoscopic screening, CRC is a leading cause of death from cancer. Administration of bovine lactoferrin (bLF) suppresses carcinogenesis in the colon and other organs of test animals, and recently it was shown that ingestion of bLF inhibits the growth of adenomatous polyps in human patients. Here we review work which established bLF as an anti-carcinogenic agent in laboratory animals and the results of a clinical trial which demonstrated that bLF can reduce the risk of colon carcinogenesis in humans.
authors.affiliation: Nanotoxicology Project, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tsuda
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kozu
authors.forename: Gen
authors.initials: G
authors.lastname: Iinuma
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Saito
authors.forename: Daizo
authors.initials: D
authors.lastname: Saito
authors.forename: Takayuki
authors.initials: T
authors.lastname: Akasu
authors.forename: David B
authors.initials: DB
authors.lastname: Alexander
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Futakuchi
authors.forename: Katsumi
authors.initials: K
authors.lastname: Fukamachi
authors.forename: Jiegou
authors.initials: J
authors.lastname: Xu
authors.forename: Tadao
authors.initials: T
authors.lastname: Kakizoe
authors.forename: Masaaki
authors.initials: M
authors.lastname: Iigo
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002417:Cattle; D015179:Colorectal Neoplasms / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D007781:Lactoferrin / Q000494:pharmacology*
chemical_list: D016588:Anticarcinogenic Agents; D007781:Lactoferrin