Role of cerebellar vermis in memory consolidation in different types of defense behavior.
Cycloheximide application on the cerebellar vermis 5 min after learning impairs consolidation of long-term extinction of the defense component of the acoustic startle response. Application 2 hours after training inhibits consolidation of extinction of orientation and exploratory components of the acoustic startle response and long-term fear memory in the experimental chamber before the start of acoustic stimulation. These findings indicate that the cerebellar vermis is selectively involved in long-term memory formation in certain types of defense behavior at different time after training.
Storozheva
Z I
ZI
PK Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow, Russia. storozheva_zi@mail.ru
D000161:Acoustic Stimulation; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D002531:Cerebellum / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D003513:Cycloheximide / Q000494:pharmacology; D005108:Extinction, Psychological / Q000187:drug effects / Q000502:physiology; D005239:Fear / Q000502:physiology*; D007858:Learning / Q000187:drug effects / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology*; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013216:Reflex, Startle / Q000187:drug effects / Q000502:physiology
D011500:Protein Synthesis Inhibitors; D003513:Cycloheximide