title: Lower-extremity function in cognitively healthy aging, mild cognitive impairment, and Alzheimer's disease.
abstract: OBJECTIVE
  To examine differences in lower-extremity function in cognitive healthy older persons, older persons with mild cognitive impairment (MCI), and older persons with Alzheimer's disease (AD).
  
  
  METHODS
  Descriptive study.
  
  
  METHODS
  University Alzheimer's disease clinical and research program.
  
  
  METHODS
  Older persons (N=66) were studied (mean age, 76.7y); 22 were cognitively normal, 22 were diagnosed with probable MCI, 22 were diagnosed with probable AD.
  
  
  METHODS
  Not applicable.
  
  
  METHODS
  Lower-extremity function was assessed by the four-meter walk test (4MWT), Timed Up & Go (TUG) test, and sit-to-stand (STS) test.
  
  
  RESULTS
  Analysis of variance, adjusting for covariates, revealed that performance on the 4MWT was significantly lower in the MCI and AD groups as compared with controls. TUG test performance was worse in the AD group compared with controls. No significant group differences were found for STS performance.
  
  
  CONCLUSIONS
  These results suggest an association between cognitive impairment and lower-limb function in older persons. Walking speed could be evaluated for its possible utility in screening older persons at risk for cognitive impairment and falls.
authors.affiliation: Alzheimer's Disease Clinical and Research Program, Boston University School of Medicine, Boston, MA 02118-2526, USA.
authors.forename: Laura H
authors.initials: LH
authors.lastname: Eggermont
authors.forename: Brandon E
authors.initials: BE
authors.lastname: Gavett
authors.forename: Karin M
authors.initials: KM
authors.lastname: Volkers
authors.forename: Christiaan G
authors.initials: CG
authors.lastname: Blankevoort
authors.forename: Erik J
authors.initials: EJ
authors.lastname: Scherder
authors.forename: Angela L
authors.initials: AL
authors.lastname: Jefferson
authors.forename: Eric
authors.initials: E
authors.lastname: Steinberg
authors.forename: Anil
authors.initials: A
authors.lastname: Nair
authors.forename: Robert C
authors.initials: RC
authors.lastname: Green
authors.forename: Robert A
authors.initials: RA
authors.lastname: Stern
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000150:complications / Q000503:physiopathology*; D003072:Cognition Disorders / Q000150:complications / Q000503:physiopathology*; D005260:Female; D020233:Gait Disorders, Neurologic / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D035002:Lower Extremity / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D026741:Physical Therapy Modalities; D012720:Severity of Illness Index; D016138:Walking
references.citation: J Psychiatr Res. 1975 Nov;12(3):189-98
references.pmid: 1202204
references.citation: J Am Geriatr Soc. 1991 Feb;39(2):142-8
references.pmid: 1991946
references.citation: Alzheimer Dis Assoc Disord. 2006 Jan-Mar;20(1):37-40
references.pmid: 16493234
references.citation: J Neurol Neurosurg Psychiatry. 2007 Sep;78(9):929-35
references.pmid: 17237140
references.citation: Neurosci Biobehav Rev. 2007;31(4):485-97
references.pmid: 17306372
references.citation: J Gerontol A Biol Sci Med Sci. 2005 Oct;60(10):1304-9
references.pmid: 16282564
references.citation: J Am Geriatr Soc. 2003 Nov;51(11):1633-7
references.pmid: 14687395
references.citation: Exp Aging Res. 2007 Jul-Sep;33(3):355-71
references.pmid: 17497375
references.citation: J Gerontol A Biol Sci Med Sci. 2000 Nov;55(11):M691-7
references.pmid: 11078100
references.citation: J Gerontol A Biol Sci Med Sci. 2001 Oct;56(10):M633-7
references.pmid: 11584036
references.citation: J Am Geriatr Soc. 2008 Aug;56(8):1575-7
references.pmid: 18808608
references.citation: Age Ageing. 2003 May;32(3):315-20
references.pmid: 12720619
references.citation: J Gerontol A Biol Sci Med Sci. 2000 Apr;55(4):M221-31
references.pmid: 10811152
references.citation: Arch Clin Neuropsychol. 2006 Aug;21(5):405-12
references.pmid: 16893623
references.citation: J Clin Epidemiol. 2008 Feb;61(2):186-91
references.pmid: 18177792
references.citation: Nat Rev Neurosci. 2004 May;5(5):347-60
references.pmid: 15100718
references.citation: Neurology. 1999 Sep 22;53(5):956-62
references.pmid: 10496252
references.citation: Hum Brain Mapp. 2003 May;19(1):47-62
references.pmid: 12731103
references.citation: Dement Geriatr Cogn Disord. 2005;19(5-6):299-304
references.pmid: 15785030
references.citation: Dement Geriatr Cogn Disord. 2002;13(4):213-6
references.pmid: 12006731
references.citation: Neurobiol Aging. 2002 May-Jun;23(3):421-31
references.pmid: 11959405
references.citation: Res Q Exerc Sport. 1999 Jun;70(2):113-9
references.pmid: 10380242
references.citation: Gait Posture. 2008 Jan;27(1):91-6
references.pmid: 17383185
references.citation: J Psychiatr Res. 1982-1983;17(1):37-49
references.pmid: 7183759
references.citation: Alzheimer Dis Assoc Disord. 2006 Oct-Dec;20(4):210-6
references.pmid: 17132964
references.citation: Mov Disord. 1994 Jan;9(1):76-83
references.pmid: 8139608
references.citation: Neurology. 1984 Jul;34(7):939-44
references.pmid: 6610841
references.citation: Behav Res Methods. 2007 May;39(2):175-91
references.pmid: 17695343
references.citation: J Am Geriatr Soc. 1999 Apr;47(4):463-9
references.pmid: 10203123
references.citation: Arch Clin Neuropsychol. 2008 Mar;23(2):129-37
references.pmid: 18178372
references.citation: J Gerontol B Psychol Sci Soc Sci. 1997 Jan;52B(1):P28-39
references.pmid: 9008673
references.citation: Pain Med. 2000 Dec;1(4):340-50
references.pmid: 15101880
references.citation: J Neurol Neurosurg Psychiatry. 2006 Jul;77(7):874-6
references.pmid: 16788015
references.citation: Arch Neurol. 2006 Dec;63(12):1763-9
references.pmid: 17172617
references.citation: Dement Geriatr Cogn Disord. 2007;24(2):125-37
references.pmid: 17622760
references.citation: Neurology. 1993 Nov;43(11):2412-4
references.pmid: 8232972
references.citation: J Intern Med. 2004 Sep;256(3):240-6
references.pmid: 15324367
references.citation: J Geriatr Psychiatry Neurol. 2007 Mar;20(1):58-62
references.pmid: 17341772
references.citation: Psychol Bull. 1992 Jul;112(1):155-9
references.pmid: 19565683
references.citation: Neuropsychology. 2006 Mar;20(2):215-23
references.pmid: 16594782