Impact of RANTES, MCP-1 and IL-8 in mast cells.
Chemokines are cytokines with chemotactic properties on inflammatory cells and other cell types. RANTES, MCP-1 and related molecules, constitute the C-C class of chemokine supergene family and a group of cytokines produced by hematopoietic cells, while IL-8 constitute the C-X-C class. The roles of most of these chemokines are not well known, although members of the chemokine family are inflammatory agents. The C-C chemokine plays a role in regulating Th-cell cytokine production and leukocyte trafficking. In this study we clearly show that RANTES and MCP-1 are mediators of acute inflammatory responses. Our report describes additional biological activities for RANTES, MCP-1, and IL-8, suggesting that these chemokines play a fundamental role in histamine and serotonin generation and cell function in mast cells.
Castellani
M L
ML
De Lutiis
M A
MA
Toniato
E
E
Conti
F
F
Felaco
P
P
Fulcheri
M
M
Theoharides
T C
TC
Caraffa
A
A
Antinolfi
P
P
Conti
P
P
Cuccurullo
C
C
Ciampoli
C
C
Felaco
M
M
Orso
C
C
Salini
V
V
Cerulli
G
G
Kempuraj
D
D
Tetè
S
S
Shaik
B
B
D000818:Animals; D018932:Chemokine CCL2 / Q000502:physiology*; D018946:Chemokine CCL5 / Q000502:physiology*; D006636:Histamine Release / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000503:physiopathology; D018836:Inflammation Mediators / Q000502:physiology; D016209:Interleukin-8 / Q000502:physiology*; D008407:Mast Cells / Q000502:physiology*; D012701:Serotonin / Q000502:physiology; D015398:Signal Transduction
D018932:Chemokine CCL2; D018946:Chemokine CCL5; D018836:Inflammation Mediators; D016209:Interleukin-8; D012701:Serotonin