title: DNA interactions and promotion in antibacterial activities of ciprofloxacin drug due to formation of mixed-ligand complexes of oxovanadium(IV).
abstract: Mixed-ligand complexes of oxovanadium(IV) of the type [VOAL]*2H(2)O [where A = ciprofloxacin and L = uninegative bidentate ligands] have been synthesized and characterized using infrared spectra, electronic spectra, magnetic measurements, elemental analyses, thermal investigation, and mass spectroscopy. Here, we tried to increase an antibacterial activity of ciprofloxacin drug due to formation of mixed-ligand complexes. The complexes were found to be more potent compare to some standard drugs, ligands and metal salt against selective gram(+ve) and gram(-ve) organisms. Binding of the complexes with DNA have been investigated by spectroscopic absorption titration and viscometric techniques. The mixed-ligand complexes show good binding ability. The cleavage efficacy has been determined using gel electrophoresis method and complexes were found to be more active compared to parental ligands and metal salt.
authors.affiliation: Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India. jeenenpatel@yahoo.co.in
authors.forename: M N
authors.initials: MN
authors.lastname: Patel
authors.forename: S H
authors.initials: SH
authors.lastname: Patel
authors.forename: M R
authors.initials: MR
authors.lastname: Chhasatia
authors.forename: C R
authors.initials: CR
authors.lastname: Desai
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D002939:Ciprofloxacin / Q000737:chemistry* / Q000494:pharmacology*; D004247:DNA / Q000737:chemistry*; D053837:DNA Cleavage / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005399:Fishes; D008024:Ligands; D008297:Male; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013094:Spermatozoa / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D017968:Vanadium Compounds / Q000737:chemistry; D014783:Viscosity
chemical_list: D000900:Anti-Bacterial Agents; D008024:Ligands; D009942:Organometallic Compounds; D017968:Vanadium Compounds; D002939:Ciprofloxacin; C034028:vanadyl sulfate; D004247:DNA