title: Modifier-concept of colorectal carcinogenesis: lipidomics as a technical tool in pathway analysis.
abstract: In the modifier concept of intestinal carcinogenesis, lipids have been established as important variables and one focus is given to long-chain fatty acids. Increased consumption of long-chain fatty acids is in discussion to modify the development of colorectal carcinoma in humans. Saturated long-chain fatty acids, in particular, are assumed to promote carcinogenesis, whereas polyunsaturated forms are likely to act in the opposite way. At present, the molecular mechanisms behind these effects are not well understood. Recently, it has been demonstrated by lipidomics and associated molecular techniques, that activation and metabolic channeling of long-chain fatty acids are important mechanisms to modify colorectal carcinogenesis. In this Editorial, an overview about the present concept of long-chain fatty acids and its derivatives in colorectal carcinogenesis as well as technical algorithms in lipid analysis is given.
authors.forename: Nikolaus
authors.initials: N
authors.lastname: Gassler
authors.forename: Christina
authors.initials: C
authors.lastname: Klaus
authors.forename: Elke
authors.initials: E
authors.lastname: Kaemmerer
authors.forename: Andrea
authors.initials: A
authors.lastname: Reinartz
mesh_terms: D000214:Acyl Coenzyme A / Q000378:metabolism; D017209:Apoptosis; D002273:Carcinogens; D015179:Colorectal Neoplasms / Q000378:metabolism*; D004041:Dietary Fats; D018450:Disease Progression; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008954:Models, Biological; D040901:Proteomics / Q000379:methods
chemical_list: D000214:Acyl Coenzyme A; D002273:Carcinogens; D004041:Dietary Fats; D005227:Fatty Acids; D008055:Lipids
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