The in vitro platelet toxicity assay (iPTA): a novel approach for assessment of drug hypersensitivity syndrome.
Elzagallaai
Abdelbaset A
AA
Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada N6A 5C1.
Rieder
Michael J
MJ
Koren
Gideon
G
D000328:Adult; D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000378:metabolism; D000927:Anticonvulsants / Q000009:adverse effects / Q000378:metabolism; D001792:Blood Platelets / Q000187:drug effects* / Q000276:immunology / Q000473:pathology / Q000502:physiology; D002220:Carbamazepine / Q000009:adverse effects / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D002648:Child; D003601:Cytotoxicity Tests, Immunologic; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D006898:Hydroxylamines / Q000009:adverse effects / Q000378:metabolism; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology; D008862:Microsomes, Liver / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013420:Sulfamethoxazole / Q000009:adverse effects / Q000378:metabolism
D000890:Anti-Infective Agents; D000927:Anticonvulsants; D006898:Hydroxylamines; D002220:Carbamazepine; D013420:Sulfamethoxazole