A consensus on criteria for cure of acromegaly.
OBJECTIVE
The Acromegaly Consensus Group met in April 2009 to revisit the guidelines on criteria for cure as defined in 2000.


METHODS
Participants included 74 neurosurgeons and endocrinologists with extensive experience of treating acromegaly. EVIDENCE/CONSENSUS PROCESS: Relevant assays, biochemical measures, clinical outcomes, and definition of disease control were discussed, based on the available published evidence, and the strength of consensus statements was rated.


CONCLUSIONS
Criteria to define active acromegaly and disease control were agreed, and several significant changes were made to the 2000 guidelines. Appropriate methods of measuring and achieving disease control were summarized.
Giustina
A
A
Department of Medical and Surgical Sciences, University of Brescia, Endocrine Service, Montichiari Hospital, Via Ciotti 154, 25018 Montichiari, Italy. a.giustina@libero.it
Chanson
P
P
Bronstein
M D
MD
Klibanski
A
A
Lamberts
S
S
Casanueva
F F
FF
Trainer
P
P
Ghigo
E
E
Ho
K
K
Melmed
S
S
D000172:Acromegaly / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy*; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D017410:Practice Guidelines as Topic
D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I