Alternative sources of pluripotent stem cells: ethical and scientific issues revisited.
Stem cell researchers in the United States continue to face an uncertain future, because of the changing federal guidelines governing this research, the restrictive patent situation surrounding the generation of new human embryonic stem cell lines, and the ethical divide over the use of embryos for research. In this commentary, we describe how recent advances in the derivation of induced pluripotent stem cells and the isolation of germ-line-derived pluripotent stem cells resolve a number of these uncertainties. The availability of patient-matched, pluripotent stem cells that can be obtained by ethically acceptable means provides important advantages for stem cell researchers, by both avoiding protracted ethical debates and giving U.S. researchers full access to federal funding. Thus, ethically uncompromised stem cells, such as those derived by direct reprogramming or from germ-cell precursors, are likely to yield important advances in stem cell research and move the field rapidly toward clinical applications.
Condic
Maureen L
ML
Department of Neurobiology and Anatomy, University of Utah School of Medicine, Salt Lake City, Utah 84132-3401, USA. mlcondic@neuro.utah.edu
Rao
Mahendra
M
D000818:Animals; D053595:Embryonic Stem Cells / Q000166:cytology; D005854:Germ Cells / Q000166:cytology; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology; D039904:Pluripotent Stem Cells / Q000166:cytology*; D057905:Stem Cell Research / Q000191:economics / Q000941:ethics* / Q000331:legislation & jurisprudence
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