title: [Feasibility study of ginsenoside Rg1 administrated via intranasal route].
abstract: OBJECTIVE
  To study the feasibility of ginsenoside Rg1 administrated from nasal route.
  
  
  METHODS
  The safty of ginsenoside Rg1 was evaluated by testing cilia movement of the in situ toad palate model. The stability of ginsenoside Rg1 to nasal enzymes and pH was evaluated by HPLC method. Nasal circulatory perfusion test in vivo had been empolyed to investigated absorption effect of ginsenoside Rg1 from nasal mucosa.
  
  
  RESULTS
  Ginsenoside Rg1 was safe to the cilia movement. Meanwhile, it's stable to nasal enzymes and pH. Ginsenoside Rg1 can be absorbed from nasal route.
  
  
  CONCLUSIONS
  It's feasible to administrate ginsenoside Rg1 from nasal route.
authors.affiliation: Shan Dong Traditional Chinese Medical Uinversity, Jinan 250355, China. xinmeichen@126.com
authors.forename: Xinmei
authors.initials: X
authors.lastname: Chen
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D005260:Female; D036145:Ginsenosides / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D036145:Ginsenosides; C035054:ginsenoside Rg1