title: Evaluation of MR spectroscopy and diffusion-weighted MRI in detecting bone marrow changes in postmenopausal women with osteoporosis.
abstract: OBJECTIVE
  To prospectively investigate the role of MR spectroscopy (MRS) and diffusion-weighted magnetic resonance imaging (DWI) in assessing vertebral marrow changes in postmenopausal women with osteoporosis.
  
  
  METHODS
  Seventy-eight postmenopausal women (mean age 63.7+/-3.5 years; range 55-81 years), who underwent dual-energy x-ray absorptiometry of the spine, were divided into three bone density groups (24 with normal, 25 with osteopaenic, and 29 with osteoporotic) based on T score. Both MRS and DWI of the L3 vertebral body were performed to calculate the marrow fat content and apparent diffusion coefficient (ADC). The results were compared between three groups and correlated with BMD.
  
  
  RESULTS
  Vertebral marrow fat content was significantly increased in the osteoporotic group (59.97+/-5.78%), when compared with that of the osteopaenic group (53.04+/-7.66%, p=0.001) and the normal bone density group (48.79+/-7.1%, p<0.001). ADC values in the osteoporotic, osteopaenic, and normal bone density groups were 0.39+/-0.02x10(-3)mm(2)/s, 0.41+/-0.02x10(-3)mm(2)/s, and 0.47+/-0.03x10(-3)mm(2)/s, respectively, with statistically significant difference (P<0.001). A statistically significant positive correlation between T scores and ADC existed (r=0.835, p<0.001). The vertebral marrow fat content was negatively correlated to the bone density (r=-0.639, p<0.001) and to marrow ADC (r=-0.554, p<0.001).
  
  
  CONCLUSIONS
  The postmenopausal women with osteoporosis exhibited a corresponding increase in vertebral marrow fat content as the bone density decreased. Marrow fat content and ADC were related to the bone density. MRS and DWI are helpful in evaluating the bone marrow changes in postmenopausal women.
authors.affiliation: Department of Radiology, Affiliated Tenth People's Hospital of Tongji University, Shanghai, China. tgy17@126.com
authors.forename: G Y
authors.initials: GY
authors.lastname: Tang
authors.forename: Z W
authors.initials: ZW
authors.lastname: Lv
authors.forename: R B
authors.initials: RB
authors.lastname: Tang
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: Y F
authors.initials: YF
authors.lastname: Peng
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: Y S
authors.initials: YS
authors.lastname: Cheng
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density / Q000502:physiology; D001855:Bone Marrow Diseases / Q000175:diagnosis*; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000175:diagnosis*