title: [Antipyretic strategies for acute stroke: a nationwide survey among German stroke units].
abstract: BACKGROUND
  Fever in acute stroke is associated with poor prognosis, but evidence-based recommendations on antipyretic therapy are lacking.
  
  
  METHODS
  A nation-wide survey was carried out among all certified stoke units in Germany about principles and organization of antipyretic strategies.
  
  
  RESULTS
  In all cases antipyretic treatment is the standard of care. The use of paracetamol is part of the first-line therapy in 94%. In cases of non-response, distinct heterogeneity of therapeutic methods and intensities becomes apparent leading potentially to insufficient antipyretic treatment.
  
  
  CONCLUSIONS
  So far, there is uncertainty about the optimal antipyretic treatment strategy after acute stroke. While current guidelines are not very explicit, efforts should be made to define a standardized, evidence-based antipyretic protocol to improve patient care, outcome on stroke units and comparability of therapeutic strategies.
authors.affiliation: Neurologische Klinik der Friedrich-Alexander-Universität Erlangen-Nürnberg, Schwabachanlage 6, Erlangen, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Kallmünzer
authors.forename: A
authors.initials: A
authors.lastname: Beck
authors.forename: S
authors.initials: S
authors.lastname: Schwab
authors.forename: R
authors.initials: R
authors.lastname: Kollmar
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D017679:Cryotherapy; D003625:Data Collection; D004177:Dipyrone / Q000627:therapeutic use; D005858:Germany; D006782:Hospitals, Special; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use; D017410:Practice Guidelines as Topic; D020521:Stroke / Q000188:drug therapy*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D018712:Analgesics, Non-Narcotic; D000082:Acetaminophen; D004177:Dipyrone; D007052:Ibuprofen
references.citation: Lancet. 1996 Feb 17;347(8999):422-5
references.pmid: 8618482
references.citation: Stroke. 2001 Jul;32(7):1607-12
references.pmid: 11441208
references.citation: Br J Anaesth. 1997 Feb;78(2):123-7
references.pmid: 9068325
references.citation: Cerebrovasc Dis. 2008;25(5):457-507
references.pmid: 18477843
references.citation: Clin Infect Dis. 1997 Jun;24(6):1208-13
references.pmid: 9195084
references.citation: Eur J Clin Pharmacol. 2005 Jan;60(11):821-9
references.pmid: 15580488
references.citation: Brain. 2007 Dec;130(Pt 12):3063-74
references.pmid: 17478443
references.citation: Stroke. 2009 Dec;40(12):e657-65
references.pmid: 19762706
references.citation: Stroke. 2009 Sep;40(9):3051-9
references.pmid: 19644066
references.citation: N Engl J Med. 2002 Feb 21;346(8):549-56
references.pmid: 11856793
references.citation: Nurs Crit Care. 2003 Jan-Feb;8(1):37-45
references.pmid: 12680517
references.citation: Stroke. 2000 Feb;31(2):410-4
references.pmid: 10657414
references.citation: Clin Infect Dis. 2000 Oct;31 Suppl 5:S224-9
references.pmid: 11113027
references.citation: Stroke. 2009 May;40(5):1907-9
references.pmid: 19182084
references.citation: Neurology. 2001 Dec 26;57(12):2301-3
references.pmid: 11756615
references.citation: BMC Cardiovasc Disord. 2003 Feb 6;3:2
references.pmid: 12657165
references.citation: Clin Geriatr Med. 1994 Feb;10(1):213-29
references.pmid: 8168025
references.citation: Lancet Neurol. 2009 May;8(5):434-40
references.pmid: 19297248
references.citation: Stroke. 2002 Jan;33(1):130-4
references.pmid: 11779901
references.citation: Cochrane Database Syst Rev. 2009 Jan 21;(1):CD001247
references.pmid: 19160194
references.citation: Stroke. 1996 Sep;27(9):1578-85
references.pmid: 8784133
references.citation: J Int Med Res. 2002 Sep-Oct;30(5):488-95
references.pmid: 12449518
references.citation: JAMA. 1986 Oct 3;256(13):1749-57
references.pmid: 3747087
references.citation: Acad Emerg Med. 2006 Aug;13(8):820-7
references.pmid: 16766740
references.citation: Neurology. 2000 Jan 25;54(2):354-61
references.pmid: 10668696
references.citation: Stroke. 2008 Nov;39(11):3029-35
references.pmid: 18723420