Dengue vaccines: state of the art.
BACKGROUND
Dengue is a significant public health problem transcending geographical boundaries to place nearly 50% of the global population at risk. A vaccine to prevent dengue is an unmet need that should be addressed urgently.


METHODS
A brief introduction to dengue and a detailed review of the classical and modern approaches being undertaken currently to develop dengue vaccines described in recent patent literature, highlighting the inherent hurdles and challenges.


RESULTS
An understanding of the approaches being deployed to develop multiple viral and non-viral vaccine candidates and an appreciation of the complexity of developing dengue vaccines.


CONCLUSIONS
Live viral vaccines, which have advanced to clinical trials, have revealed new challenges, emphasizing the need to pursue non-viral alternatives simultaneously.
Swaminathan
Sathyamangalam
S
International Centre for Genetic Engineering & Biotechnology, Recombinant Gene Products Group, PO Box 10504, Aruna Asaf Ali Marg, New Delhi-110067, India. swami@icgeb.res.in
Batra
Gaurav
G
Khanna
Navin
N
D000818:Animals; D003715:Dengue / Q000276:immunology / Q000517:prevention & control*; D053059:Dengue Vaccines / Q000276:immunology*; D003716:Dengue Virus / Q000187:drug effects* / Q000276:immunology; D015195:Drug Design; D006801:Humans; D010330:Patents as Topic; D011634:Public Health
D053059:Dengue Vaccines