Vitamin d deficiency and tuberculosis progression.
To assess the association between vitamin D deficiency and tuberculosis disease progression, we studied vitamin D levels in a cohort of tuberculosis patients and their contacts (N = 129) in Pakistan. Most (79%) persons showed deficiency. Low vitamin D levels were associated with a 5-fold increased risk for progression to tuberculosis.
Talat
Najeeha
N
Aga Khan University, Karachi, Pakistan.
Perry
Sharon
S
Parsonnet
Julie
J
Dawood
Ghaffa
G
Hussain
Rabia
R
D000293:Adolescent; D000328:Adult; D002648:Child; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis; D012307:Risk Factors; D012737:Sex Factors; D012959:Socioeconomic Factors; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000382:microbiology / Q000473:pathology*; D014808:Vitamin D Deficiency / Q000209:etiology*
Infect Immun. 1987 Dec;55(12):2945-50
3119492
Trends Microbiol. 2008 Jul;16(7):336-44
18513971
Int J Epidemiol. 2008 Feb;37(1):113-9
18245055
J Coll Physicians Surg Pak. 2009 May;19(5):267-8
19409155
Clin Vaccine Immunol. 2007 Dec;14(12):1578-86
17928427
N Engl J Med. 2007 Jul 19;357(3):266-81
17634462
Thorax. 1985 Mar;40(3):187-90
3872485
Clin Infect Dis. 2008 Feb 1;46(3):443-6
18173355
Science. 2006 Mar 24;311(5768):1770-3
16497887
J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):793-8
17223549
J Pak Med Assoc. 2008 Sep;58(9):482-4
18846794
J Immunol. 2007 Jun 1;178(11):7190-8
17513768
Am J Respir Crit Care Med. 2009 May 1;179(9):843-50
19179490
Am Rev Respir Dis. 1988 Oct;138(4):768-70
2849343