Constituents from the testas of Castanea mollissima Blume with alpha-glucosidase inhibitory activity.
In the screening of biologically active constituents from medicinal plants, the 75% EtOH extract of the testas of Castanea mollissima Blume showed potent alpha-glucosidase inhibitory activity. By means of various chromatographic methods, the extract gave a new dammarane-type triterpene 1 along with 17 known compounds. The structure of 1 was determined to be 3beta-acetoxy-20-oxo-21-nordammaran-23-oic acid by HRMS and NMR studies including 2D NMR experiments. The new compound and some known compounds showed potent alpha-glucosidase inhibitory activity with acarbose as a positive control.
Gao
Hui-Yuan
HY
School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang, China.
Wu
Di
D
Lu
Chuan
C
Xu
Xiao-Min
XM
Huang
Jian
J
Sun
Bo-Hang
BH
Wu
Li-Jun
LJ
D029962:Fagaceae / Q000737:chemistry; D065089:Glycoside Hydrolase Inhibitors; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
C549176:3beta-acetoxy-20-oxo-21-nordammaran-23-oic acid; D065089:Glycoside Hydrolase Inhibitors; D014315:Triterpenes