title: Impaired sperm aggregation in Adam2 and Adam3 null mice.
abstract: Previous studies have shown that sperm from Adam2 and Adam3 knockout mice have defective migration in the female reproductive tracts and cannot bind to the egg's zona pellucida (ZP), which leads to infertility. Here, we report that Adam2 and Adam3 knockout sperm have severely impaired sperm aggregation and that this defect is not restored over time during in vitro cultivation, suggesting the requirement of ADAM2 and ADAM3 in normal sperm association.
authors.affiliation: Department of Life Science, Gwangju Institute of Science and Technology, Gwangju, South Korea.
authors.forename: Cecil
authors.initials: C
authors.lastname: Han
authors.forename: Jun Tae
authors.initials: JT
authors.lastname: Kwon
authors.forename: Inju
authors.initials: I
authors.lastname: Park
authors.forename: Boyeon
authors.initials: B
authors.lastname: Lee
authors.forename: Sora
authors.initials: S
authors.lastname: Jin
authors.forename: Heejin
authors.initials: H
authors.lastname: Choi
authors.forename: Chunghee
authors.initials: C
authors.lastname: Cho
mesh_terms: D051722:ADAM Proteins / Q000172:deficiency*; D000818:Animals; D002449:Cell Aggregation / Q000502:physiology*; D005260:Female; D000072196:Fertilins; D008297:Male; D008562:Membrane Glycoproteins / Q000172:deficiency*; D051379:Mice; D018345:Mice, Knockout; D013094:Spermatozoa / Q000378:metabolism* / Q000502:physiology; D015044:Zona Pellucida / Q000378:metabolism*
chemical_list: D008562:Membrane Glycoproteins; D051722:ADAM Proteins; C000606458:Adam2 protein, mouse; C485429:Adam3 protein, mouse; D000072196:Fertilins