title: Potent inhibition of protein tyrosine phosphatase 1B by copper complexes: implications for copper toxicity in biological systems.
abstract: A new dinuclear copper complex and several Cu-amino acid complexes inhibit protein tyrosine phosphatase 1B competitively at submicromolar levels, suggesting that copper complexes may interfere with cellular signaling pathways by inhibiting protein tyrosine phosphatases.
authors.affiliation: Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, PR China.
authors.forename: Qingming
authors.initials: Q
authors.lastname: Wang
authors.forename: Liping
authors.initials: L
authors.lastname: Lu
authors.forename: Caixia
authors.initials: C
authors.lastname: Yuan
authors.forename: Kai
authors.initials: K
authors.lastname: Pei
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Liu
authors.forename: Maolin
authors.initials: M
authors.lastname: Guo
authors.forename: Miaoli
authors.initials: M
authors.lastname: Zhu
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects*
chemical_list: D000596:Amino Acids; D009942:Organometallic Compounds; D003300:Copper; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1