Design, synthesis, and complementary recognition of beta-hairpin peptides stabilized by artificial DNA base-pairing amino acids.
A novel DNA base-pairing beta-hairpin peptide involving intramolecular hydrogen bonds for induction of beta-hairpin secondary structure and intermolecular complementary hydrogen bonds between thymine and diaminopyridine for molecular recognition has been synthesized.
Isozaki
Katsuhiro
K
Organic Nanomaterials Center, National Institute for Materials Science, 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan. ISOZAKI.Katsuhiro@nims.go.jp
Miki
Kazushi
K
D000596:Amino Acids / Q000737:chemistry*; D000631:Aminopyridines / Q000737:chemistry; D020029:Base Pairing; D004247:DNA / Q000737:chemistry*; D006860:Hydrogen Bonding; D020135:Peptide Nucleic Acids / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D017433:Protein Structure, Secondary; D013941:Thymine / Q000737:chemistry
D000596:Amino Acids; D000631:Aminopyridines; D020135:Peptide Nucleic Acids; D010455:Peptides; D004247:DNA; D013941:Thymine