Neuromagnetic biomarkers of visuocortical development in healthy children.
OBJECTIVE
The objective of the present study was to investigate noninvasive biomarkers for visuocortical development in healthy children.


METHODS
Sixty healthy children and 20 adults were studied with a whole-head magnetoencephalography (MEG) system. The adults were included to find out when the markers stabilize. Visual evoked magnetic fields (VEFs) were evoked with full-field pattern-reversal checks.


RESULTS
Three response peaks were identified at 77+/-8 ms (M75), 111+/-9 ms (M100) and 150+/-11 ms (M145) for children. The latency of M75 and M100 decreased with age (p<0.01). The amplitude ratio of M100/M75 increased significantly with age (p<0.001). The differences of MEG source images between the left and right occipital cortices for M75 and M145 increased significantly with age (r=0.47 and 0.46, respectively, p<0.01).


CONCLUSIONS
The latency of M75 and M100 and the amplitude ratio of M100/M75 are robust biomarkers for the development of visual function in children.


CONCLUSIONS
The development of visual function in childhood is noninvasively measurable. The results lay a foundation for quantitative identification of developmental delay and/or abnormalities of visual function in children with brain disorders.
Chen
Yangmei
Y
Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA; Department of Neurology, The Second Affiliated Hospital, Chongqing Medical University, 76 Lin Jiang Road, Chongqing 400010, China.
Xiang
Jing
J
Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Electronic address: jing.xiang@cchmc.org.
Kirtman
Elijah G
EG
Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Wang
Yingying
Y
Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Kotecha
Rupesh
R
Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Liu
Yang
Y
Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D015415:Biomarkers; D001931:Brain Mapping; D002648:Child; D005260:Female; D006801:Humans; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods; D015225:Magnetoencephalography / Q000379:methods; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation / Q000379:methods; D011930:Reaction Time / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology*; D055815:Young Adult
D015415:Biomarkers