An efficient method for the synthesis of unsymmetrical 2,2'-bis(pyrrolyl)alkanes.
A new strategy for the preparation of unsymmetrical 2,2'-bis(pyrrolyl)alkanes has been developed. It involved the condensation of pyrrole derivatives onto N-benzylhydroxylamines in the presence of HCl. This two-step procedure provided access to a wide variety of 2,2'-dipyrromethanes (3a-m). It has also been extended to the synthesis of tripyrromethanes 4a-d and of N-confused dipyrromethanes 6a-d.
Murat-Onana
Marie Laure
ML
Département de Chimie Moléculaire (SERCO), UMR-5250, ICMG FR-2607, Université Joseph Fourier, CNRS, BP-53, 38041 Grenoble cedex 9, France.
Berini
Christophe
C
Minassian
Frédéric
F
Pelloux-Léon
Nadia
N
Denis
Jean-Noël
JN
D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
D000473:Alkanes; D011758:Pyrroles