title: The risk of performing cardiopulmonary bypass in malaria patients: a small case series.
abstract: The effects of cardiopulmonary bypass on patients who have active or dormant malaria are unknown. What is known is that malaria-induced hemolysis can be exacerbated by cardiopulmonary bypass. We report 3 cases in which patients with active or dormant malaria underwent open-heart surgery. Two of them received quinine prophylaxis, and the 3rd patient (who presented with an active infection) received longer-term preoperative treatment with quinine. In all 3 cases, the surgery was performed uneventfully. We suggest preoperative quinine prophylaxis for patients with a history of malaria whose blood smears are negative for parasites, and we advocate more radical preoperative treatment with quinine for patients whose blood smears are positive at presentation. These measures appear to prevent hemolysis and fever during both the preoperative and postoperative periods. However, there is need of a multicenter study to ascertain the actual effects of cardiopulmonary bypass on patients with malaria.
authors.affiliation: Cardiovascular Intensive Care Unit, Mohamed V Military Hospital, Rabat, Morocco. moutaouekkil@hotmail.com
authors.forename: El Mehdi
authors.initials: el M
authors.lastname: Moutaouekkil
authors.forename: Mohamed
authors.initials: M
authors.lastname: Drissi
authors.forename: Mahdi Ait
authors.initials: MA
authors.lastname: Houssa
authors.forename: Abdelletif
authors.initials: A
authors.lastname: Boulahya
authors.forename: Abdelmajid
authors.initials: A
authors.lastname: El Kirat
mesh_terms: D000962:Antimalarials / Q000008:administration & dosage*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D002648:Child; D004334:Drug Administration Schedule; D005260:Female; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D008288:Malaria / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D011300:Preoperative Care; D011802:Quinidine / Q000008:administration & dosage*; D018570:Risk Assessment; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials; D011802:Quinidine
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