Primary ovarian mucinous cystic tumor with prominent theca cell proliferation and focal granulosa cell tumor in its stroma: case report, literature review, and comparison with Sertoli-Leydig cell tumor with heterologous elements.
A 73-year-old woman was found to have a 22 cm unilateral multilocular mucinous cystic tumor of the ovary. Microscopic examination showed a routine appearance of the epithelial component, which ranged from benign to borderline to low-grade carcinoma. The stromal component was unusual because of a striking cellular theca cell component in the stroma, which, in turn, merged with a component of adult granulosa cell tumor. The "parent" neoplasm in this case and 3 other similar cases in the literature appears to be the mucinous neoplasm, in contrast with the other example of mucinous neoplasia associated with sex cord neoplasia, the Sertoli-Leydig cell tumor with heterologous elements, in which the "parent" neoplasm is likely the Sertoli-Leydig cell tumor.
Staats
Paul N
PN
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. pstaats@umm.edu
Coutts
Michael A
MA
Young
Robert H
RH
D002288:Adenocarcinoma, Mucinous / Q000473:pathology* / Q000601:surgery; D000368:Aged; D005260:Female; D006106:Granulosa Cell Tumor / Q000473:pathology* / Q000601:surgery; D006651:Histocytochemistry; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D018310:Sertoli-Leydig Cell Tumor / Q000473:pathology*; D013798:Thecoma / Q000473:pathology* / Q000601:surgery