[Feasibility study of ginsenoside Rg1 administrated via intranasal route].
OBJECTIVE
To study the feasibility of ginsenoside Rg1 administrated from nasal route.


METHODS
The safty of ginsenoside Rg1 was evaluated by testing cilia movement of the in situ toad palate model. The stability of ginsenoside Rg1 to nasal enzymes and pH was evaluated by HPLC method. Nasal circulatory perfusion test in vivo had been empolyed to investigated absorption effect of ginsenoside Rg1 from nasal mucosa.


RESULTS
Ginsenoside Rg1 was safe to the cilia movement. Meanwhile, it's stable to nasal enzymes and pH. Ginsenoside Rg1 can be absorbed from nasal route.


CONCLUSIONS
It's feasible to administrate ginsenoside Rg1 from nasal route.
Chen
Xinmei
X
Shan Dong Traditional Chinese Medical Uinversity, Jinan 250355, China. xinmeichen@126.com
D000281:Administration, Intranasal; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D004355:Drug Stability; D005260:Female; D036145:Ginsenosides / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008297:Male; D009297:Nasal Mucosa / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D036145:Ginsenosides; C035054:ginsenoside Rg1