Cyclin B-Cdk1 activates its own pump to get into the nucleus.
The transition to mitosis requires extensive nuclear and cytoplasmic rearrangements that must be spatially and temporally coordinated. In this issue, Gavet and Pines (2010a. J. Cell Biol. doi:10.1083/jcb.200909144) report on a simple yet elegant mechanism as to how this is achieved. By monitoring the activity of cyclin B-Cdk1 in real time, the authors show that concomitant with its activation in the cytoplasm, the kinase complex is rapidly imported into the nucleus by modifying the activity of the nucleocytoplasmic transport machinery. Thus, cyclin B-Cdk1 activates its own pump to get into the nucleus.
Lindqvist
Arne
A
Department of Medical Oncology, University Medical Center Utrecht, 3584CG Utrecht, Netherlands. a.lindqvist@umcutrecht.nl
D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D016203:CDC2 Protein Kinase / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle / Q000502:physiology; D002467:Cell Nucleus / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D019926:Cyclin B / Q000235:genetics / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D004789:Enzyme Activation
D002843:Chromatin; D019926:Cyclin B; D016203:CDC2 Protein Kinase
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