Prenylated benzophenone peroxide derivatives from Hypericum sampsonii.
Two new prenylated benzophenone peroxide derivatives, peroxysampsones A and B (1 and 2, resp.), together with a known compound, plukenetione C (3), were isolated from the roots of the Chinese medicinal plant Hypericum sampsonii, and their structures were elucidated by detailed spectral analysis. These compounds are the unusual peroxides of polyprenylated benzophenone derivatives, containing the unique caged moiety of 4,5-dioxatetracyclo[9.3.1.1(9,13).0(1,7)]hexadecane-12,14,15-trione. In the biological test, peroxysampsone A (1) showed comparable activity with norfloxacin against a NorA over-expressing multidrug-resistant (MDR) strain of Staphylococcus aureus SA-1199B.
Xiao
Zhi Yong
ZY
School of Pharmacy, Fudan University, Zhangheng Road 826, Zhangjiang Pudong, Shanghai 200032, P. R. China.
Zeng
Yi Han
YH
Mu
Qing
Q
Shiu
Winnie Ka Po
WK
Gibbons
Simon
S
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001577:Benzophenones / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry* / Q000494:pharmacology; D020902:Hypericum / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008968:Molecular Conformation; D010545:Peroxides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D054876:Prenylation
D000900:Anti-Bacterial Agents; D001577:Benzophenones; D006576:Heterocyclic Compounds, 4 or More Rings; D010545:Peroxides; C550988:peroxysampsone A; C550989:peroxysampsone B; C047723:benzophenone