title: On the potential of natural products in the discovery of pharma leads: a case for reassessment.
abstract: The central proposition advanced herein is that complex target oriented synthesis, enabled by historic advances in methodology, has enormously expanded the scope of the possible. Accordingly, natural products, a proven long-term source of pharma discovery, re-emerge as potentially valuable elements for synthesis-driven pharma exploitation.
authors.affiliation: Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
authors.forename: Samuel
authors.initials: S
authors.lastname: Danishefsky
mesh_terms: D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D055808:Drug Discovery; D034261:Epothilones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018942:Macrolides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009231:Myxococcales / Q000737:chemistry; D010881:Piperidones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry
chemical_list: D001688:Biological Products; D034261:Epothilones; D018942:Macrolides; D010881:Piperidones; C418199:migrastatin