title: Dietary B vitamin intakes and urinary total arsenic concentration in the Health Effects of Arsenic Longitudinal Study (HEALS) cohort, Bangladesh.
abstract: OBJECTIVE
  The objective of this analysis was to evaluate the effects of dietary B vitamin intakes on creatinine-adjusted urinary total arsenic concentration among individuals participating in the Health Effects of Arsenic Longitudinal Study (HEALS) cohort in Araihazar, Bangladesh. Arsenic exposure is a major public health problem in Bangladesh, where nearly 77 million people have been chronically exposed to arsenic through the consumption of naturally contaminated groundwater. Dietary factors influencing the metabolism of ingested arsenic may potentially be important modifiers of the health effects of arsenic in this population.
  
  
  METHODS
  Daily average B vitamin intakes from a validated food frequency questionnaire and laboratory data on drinking water and urinary arsenic concentrations among 9,833 HEALS cohort participants were utilized. Statistical analyses were conducted using generalized estimating equations incorporating knotted spline linear regression.
  
  
  RESULTS
  Increasing dietary intakes of thiamin, niacin, pantothenic acid, and pyridoxine were found to significantly increase urinary total arsenic excretion, adjusted for daily arsenic intake from drinking water and other potential confounders.
  
  
  CONCLUSIONS
  These results suggest that higher intakes of certain B vitamins may enhance the excretion of arsenic from the body. This study offers new insights into modifiable dietary factors that relate to arsenic excretion and thus provides potential avenues for the prevention of arsenic-related health effects.
authors.affiliation: Department of Health Studies, The University of Chicago, 5841 S. Maryland Avenue, MC2007, Chicago, IL 60637, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Argos
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Rathouz
authors.forename: Brandon L
authors.initials: BL
authors.lastname: Pierce
authors.forename: Tara
authors.initials: T
authors.lastname: Kalra
authors.forename: Faruque
authors.initials: F
authors.lastname: Parvez
authors.forename: Vesna
authors.initials: V
authors.lastname: Slavkovich
authors.forename: Alauddin
authors.initials: A
authors.lastname: Ahmed
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Habibul
authors.initials: H
authors.lastname: Ahsan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001151:Arsenic / Q000652:urine*; D001459:Bangladesh; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D004032:Diet / Q000706:statistics & numerical data*; D004781:Environmental Exposure / Q000032:analysis; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D020011:Protective Agents / Q000008:administration & dosage; D012737:Sex Factors; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D014803:Vitamin B Complex / Q000008:administration & dosage*; D014874:Water Pollutants, Chemical / Q000652:urine*; D055815:Young Adult
chemical_list: D020011:Protective Agents; D014874:Water Pollutants, Chemical; D014803:Vitamin B Complex; D001151:Arsenic
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