Three new indole alkaloids from Trigonostemon lii.
Three unprecedented indole alkaloids, trigonoliimines A-C (1-3) with a unique polycyclic system, were isolated from the leaves of Trigonostemon lii Y. T. Chang. The structures of 1-3 were determined by the spectroscopic, computational, and CD exciton chirality approaches. Trigonoliimine A showed modest anti-HIV-1 activity (EC(50) = 0.95 microg/mL, TI = 7.9).
Tan
Cheng-Jian
CJ
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PRC.
Di
Ying-Tong
YT
Wang
Yue-Hu
YH
Zhang
Yu
Y
Si
Yi-Kang
YK
Zhang
Qiang
Q
Gao
Suo
S
Hu
Xu-Jia
XJ
Fang
Xin
X
Li
Shi-Fei
SF
Hao
Xiao-Jiang
XJ
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry; D013237:Stereoisomerism
D019380:Anti-HIV Agents; D026121:Indole Alkaloids; C551376:trigonoliimine A; C551378:trigonoliimine B; C551377:trigonoliimine C