Genetic loci influencing kidney function and chronic kidney disease.
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
Chambers
John C
JC
Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, UK. john.chambers@ic.ac.uk
Zhang
Weihua
W
Lord
Graham M
GM
van der Harst
Pim
P
Lawlor
Debbie A
DA
Sehmi
Joban S
JS
Gale
Daniel P
DP
Wass
Mark N
MN
Ahmadi
Kourosh R
KR
Bakker
Stephan J L
SJ
Beckmann
Jacqui
J
Bilo
Henk J G
HJ
Bochud
Murielle
M
Brown
Morris J
MJ
Caulfield
Mark J
MJ
Connell
John M C
JM
Cook
H Terence
HT
Cotlarciuc
Ioana
I
Davey Smith
George
G
de Silva
Ranil
R
Deng
Guohong
G
Devuyst
Olivier
O
Dikkeschei
Lambert D
LD
Dimkovic
Nada
N
Dockrell
Mark
M
Dominiczak
Anna
A
Ebrahim
Shah
S
Eggermann
Thomas
T
Farrall
Martin
M
Ferrucci
Luigi
L
Floege
Jurgen
J
Forouhi
Nita G
NG
Gansevoort
Ron T
RT
Han
Xijin
X
Hedblad
Bo
B
Homan van der Heide
Jaap J
JJ
Hepkema
Bouke G
BG
Hernandez-Fuentes
Maria
M
Hypponen
Elina
E
Johnson
Toby
T
de Jong
Paul E
PE
Kleefstra
Nanne
N
Lagou
Vasiliki
V
Lapsley
Marta
M
Li
Yun
Y
Loos
Ruth J F
RJ
Luan
Jian'an
J
Luttropp
Karin
K
Maréchal
Céline
C
Melander
Olle
O
Munroe
Patricia B
PB
Nordfors
Louise
L
Parsa
Afshin
A
Peltonen
Leena
L
Penninx
Brenda W
BW
Perucha
Esperanza
E
Pouta
Anneli
A
Prokopenko
Inga
I
Roderick
Paul J
PJ
Ruokonen
Aimo
A
Samani
Nilesh J
NJ
Sanna
Serena
S
Schalling
Martin
M
Schlessinger
David
D
Schlieper
Georg
G
Seelen
Marc A J
MA
Shuldiner
Alan R
AR
Sjögren
Marketa
M
Smit
Johannes H
JH
Snieder
Harold
H
Soranzo
Nicole
N
Spector
Timothy D
TD
Stenvinkel
Peter
P
Sternberg
Michael J E
MJ
Swaminathan
Ramasamyiyer
R
Tanaka
Toshiko
T
Ubink-Veltmaat
Lielith J
LJ
Uda
Manuela
M
Vollenweider
Peter
P
Wallace
Chris
C
Waterworth
Dawn
D
Zerres
Klaus
K
Waeber
Gerard
G
Wareham
Nicholas J
NJ
Maxwell
Patrick H
PH
McCarthy
Mark I
MI
Jarvelin
Marjo-Riitta
MR
Mooser
Vincent
V
Abecasis
Goncalo R
GR
Lightstone
Liz
L
Scott
James
J
Navis
Gerjan
G
Elliott
Paul
P
Kooner
Jaspal S
JS
D001692:Biological Transport; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000378:metabolism; D005060:Europe; D005786:Gene Expression Regulation; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007676:Kidney Failure, Chronic / Q000235:genetics* / Q000473:pathology; D008957:Models, Genetic
D055316:Cystatin C; D005819:Genetic Markers; D003404:Creatinine
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