title: Microstimulation reveals limits in detecting different signals from a local cortical region.
abstract: Behavioral performance depends on the activity of neurons in sensory cortex, but little is known about the brain's capacity to access specific neuronal signals to guide behavior. Even the individual sensory neurons that are most sensitive to a relevant stimulus are only weakly correlated with behavior, suggesting that behavioral decisions are based on the combined activity of groups of neurons with sensitivities well matched to task demands. To explore how flexibly different patterns of activity can be accessed from a given cortical region, we trained animals to detect electrical microstimulation of local V1 sites. By allowing the animals to become expert at the detection of microstimulation of specific V1 sites that corresponded to particular retinotopic locations, we could measure the effects of that training on the ability of those sites to support the detection of visual stimuli. Training to detect electrical activation caused a large, reversible, retinotopically localized impairment of thresholds for detecting visual stimuli. Retraining on visual detection restored normal thresholds and in turn impaired thresholds for detecting microstimulation. These results suggest that there are substantial limits to the types of signals for which a local cortical region can be simultaneously optimized.
authors.affiliation: Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USA.
authors.forename: Amy M
authors.initials: AM
authors.lastname: Ni
authors.forename: John H R
authors.initials: JH
authors.lastname: Maunsell
mesh_terms: D000818:Animals; D004558:Electric Stimulation; D005133:Eye Movements / Q000502:physiology; D008253:Macaca mulatta / Q000502:physiology; D008297:Male; D009474:Neurons / Q000502:physiology; D010775:Photic Stimulation; D012160:Retina / Q000502:physiology; D012684:Sensory Thresholds / Q000502:physiology; D017603:Signal Detection, Psychological / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology; D014796:Visual Perception / Q000502:physiology
references.citation: J Neurophysiol. 2005 Nov;94(5):3443-50
references.pmid: 16079194
references.citation: Exp Brain Res. 2003 Jan;148(2):233-7
references.pmid: 12520412
references.citation: Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):9080-5
references.pmid: 15956204
references.citation: Curr Biol. 2007 May 15;17(10):862-7
references.pmid: 17462895
references.citation: Proc Natl Acad Sci U S A. 2008 May 20;105(20):7315-20
references.pmid: 18477698
references.citation: Annu Rev Psychol. 1998;49:585-612
references.pmid: 9496632
references.citation: Nat Rev Neurosci. 2003 Mar;4(3):203-18
references.pmid: 12612633
references.citation: Percept Psychophys. 1983 Feb;33(2):113-20
references.pmid: 6844102
references.citation: Med Biol Eng Comput. 1990 May;28(3):257-9
references.pmid: 2377008
references.citation: Nat Neurosci. 2009 May;12(5):655-63
references.pmid: 19377473
references.citation: J Neurosci. 1988 Jun;8(6):2201-11
references.pmid: 3385495
references.citation: Neurology. 2000 Feb 22;54(4):849-54
references.pmid: 10690975
references.citation: Neuron. 2009 Aug 27;63(4):508-22
references.pmid: 19709632
references.citation: Nature. 1998 Jan 8;391(6663):134-5
references.pmid: 9428760
references.citation: Nat Neurosci. 2000 Mar;3(3):264-9
references.pmid: 10700259
references.citation: J Neurophysiol. 2005 Jan;93(1):1-19
references.pmid: 15371496
references.citation: J Neurosci. 1992 Dec;12(12):4745-65
references.pmid: 1464765
references.citation: Annu Rev Neurosci. 1998;21:227-77
references.pmid: 9530497
references.citation: Nature. 1993 Sep 16;365(6443):250-2
references.pmid: 8371779
references.citation: J Neurophysiol. 2007 Aug;98(2):559-76
references.pmid: 17567774
references.citation: Neuron. 2008 Oct 23;60(2):367-77
references.pmid: 18957227
references.citation: Cereb Cortex. 1994 May-Jun;4(3):247-59
references.pmid: 8075530
references.citation: Vision Res. 1984;24(5):429-48
references.pmid: 6740964
references.citation: Nature. 2004 Oct 14;431(7010):775-81
references.pmid: 15483598
references.citation: Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5389-93
references.pmid: 19276119
references.citation: J Neurosci. 2007 Jul 18;27(29):7619-30
references.pmid: 17634356
references.citation: Nat Rev Neurosci. 2001 Jan;2(1):33-42
references.pmid: 11253357
references.citation: Science. 1974 Feb 1;183(4123):440-4
references.pmid: 4808973