Lipid coated mesoporous silica nanoparticles as photosensitive drug carriers.
This paper presents a strategy for the biofunctionalization of novel photosensitizer carriers, mesoporous silica nanoparticles (MSNs). After being calcined and absorbed with photosensitizers (hypocrellin B, HB), MSNs can be coated with a lipid layer. Transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM) results proved that HB molecules can be loaded into MSN porous and lipid can coated on the surface of the nanoparticles. When co-cultured with cancer cells (MCF-7), MSNs can transport HB molecules into cells and present low cytotoxicity. With the introduction of a lipid layer, the efficiency of MSN uptake by cells can be improved. These intracellular HB-loaded MSN materials also present cytotoxicity to MCF-7 cells after light irradiation which indicates the materials can be used as good photosensitizer carriers in photodynamic therapy.
Yang
Yang
Y
National Center for Nanoscience and Technology, No. 11, Bei Yi Tiao, Zhong guan cun, Beijing, 100190, China.
Song
Weixing
W
Wang
Anhe
A
Zhu
Pengli
P
Fei
Jinbo
J
Li
Junbai
J
D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D005434:Flow Cytometry; D006801:Humans; D008051:Lipid Bilayers / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D010569:Perylene / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage* / Q000633:toxicity; D016062:Porosity; D011809:Quinones / Q000008:administration & dosage* / Q000633:toxicity; D012822:Silicon Dioxide / Q000737:chemistry*
D004337:Drug Carriers; D008051:Lipid Bilayers; D017319:Photosensitizing Agents; D011809:Quinones; D010569:Perylene; D012822:Silicon Dioxide; C064522:hypocrellin B