Current status on Alzheimer disease molecular genetics: from past, to present, to future.
Linkage studies, candidate gene and whole-genome association studies have resulted in a tremendous amount of putative risk genes for Alzheimer's disease (AD). Yet, besides the three causal genes-amyloid precursor protein and presenilin 1 and 2 genes-and one risk gene apolipoprotein E (APOE), no single functional risk variant was identified. Discussing the possible involvement of rare alleles and other types of genetic variants, this review summarizes the current knowledge on the genetic spectrum of AD and integrates different approaches and recent discoveries by genome-wide association studies.
Bettens
Karolien
K
Department of Molecular Genetics, Institute Born-Bunge, University of Antwerp, Antwerpen, Belgium.
Sleegers
Kristel
K
Van Broeckhoven
Christine
C
D000544:Alzheimer Disease / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans
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