title: Sporothrix schenckii meningitis in AIDS during immune reconstitution syndrome.
abstract: Sporotrichosis is a fungal disease usually restricted to the cutaneous and lymphatic systems. Visceral involvement is unusual. To date, only 21 cases of sporotrichosis meningitis have been reported, some of these associated with immunosuppression. According to the reported cases, difficulty establishing the correct diagnosis is almost the rule which, undoubtedly, is associated with a worse prognosis. In this report, two HIV infected patients are described who developed meningitis due to Sporothrix schenckii associated with immune reconstitution inflammatory syndrome. This is the first report of sporotrichosis meningitis associated with immune reconstitution inflammatory syndrome in AIDS patients.
authors.affiliation: Evandro Chagas Clinical Research Institute (IPEC), Oswaldo Cruz Foundation (FIOCRUZ), Avenida Brasil, Rio de Janeiro, Brazil.
authors.forename: Maria Clara Gutierrez
authors.initials: MC
authors.lastname: Galhardo
authors.forename: Marcus Tulius T
authors.initials: MT
authors.lastname: Silva
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Lima
authors.forename: Estevão Portela
authors.initials: EP
authors.lastname: Nunes
authors.forename: Luiz Eduardo C
authors.initials: LE
authors.lastname: Schettini
authors.forename: Rodrigo Fernandes
authors.initials: RF
authors.lastname: de Freitas
authors.forename: Rodrigo de Almeida
authors.initials: Rde A
authors.lastname: Paes
authors.forename: Elizabeth de Sousa
authors.initials: Ede S
authors.lastname: Neves
authors.forename: Antonio Carlos Francesconi
authors.initials: AC
authors.lastname: do Valle
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000382:microbiology; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000150:complications*; D008297:Male; D016920:Meningitis, Bacterial / Q000150:complications* / Q000175:diagnosis / Q000209:etiology*; D013175:Sporothrix / Q000302:isolation & purification*; D013174:Sporotrichosis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology*; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B