title: [Plasma proteomic analysis in male normotensive, prehypertensive and hypertensive subjects].
abstract: OBJECTIVE
  To compare the plasma proteome among male normotensive, prehypertensive, and hypertensive subjects.
  
  
  METHODS
  Plasma proteome was analyzed by two-dimensional electrophoresis combined with MALDI-TOF mass spectrometry in this case-control study among well matched male normotensive, prehypertensive and hypertensive subjects (n = 26 each).
  
  
  RESULTS
  The results showed that there were 22 differentially expressed protein spots among the protein samples derived from the 3 groups which corresponded to 18 proteins associated with inflammation and immunity, lipid metabolism, transport, coagulation and fibrinolysis, cell proliferation and apoptosis, and antioxidation.
  
  
  CONCLUSIONS
  Proteins were differentially expressed in male subjects with various blood pressure levels.
authors.affiliation: Department of Hypertension, Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Attached to Capital University of Medical Sciences, Beijing 100029, China.
authors.forename: Zuo-guang
authors.initials: ZG
authors.lastname: Wang
authors.forename: Yan-duo
authors.initials: YD
authors.lastname: Tao
authors.forename: Ya
authors.initials: Y
authors.lastname: Liu
authors.forename: Jie-lin
authors.initials: JL
authors.lastname: Liu
authors.forename: Xin-jun
authors.initials: XJ
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Wen
authors.forename: Shao-jun
authors.initials: SJ
authors.lastname: Wen
authors.forename: Zhao-su
authors.initials: ZS
authors.lastname: Wu
mesh_terms: D000328:Adult; D001794:Blood Pressure; D016022:Case-Control Studies; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D058246:Prehypertension / Q000235:genetics* / Q000503:physiopathology*; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization