title: Investigating Association of Three Polymorphisms of Coagulation Factor XIII and Recurrent Pregnancy Loss.
abstract: OBJECTIVE
  among important suspected causes of thrombophilia in women with recurrent pregnancy loss (RPL) are the polymorphisms of coagulation factor XIII (FXIII) gene. We performed a case-control study on the association between three polymorphisms of factor XIII (FXIII G103T, FXIII A614T and FXIII C1694T) and RPL in Iranian women.
  
  
  METHODS
  DNA samples from peripheral blood of 100 female patients with at least two recurrent abortions, as case group, and 100 healthy women with history of at least two successful deliveries were subjected to PCR-RFLP, and the frequencies of the polymorphisms were calculated and compared between the two groups.
  
  
  RESULTS
  the prevalence of FXIII G103T polymorphism was 29% in the case group and 17% in the control group (P = 0.158). The frequencies of FXIII A614T and FXIII C1694T were 84% and 66% in the case group and 48% and 31% in the control group (P <0.001 and P < 0.001), respectively. The two latter polymorphisms are associated with RPL in Iranian women and increase the risk of RPL. A correlation was also found between FXIII A614T and FXIII C1694T polymorphisms (P < 0.001).
  
  
  CONCLUSIONS
  we suggest the evaluation of FXIII A614T and FXIII C1694T polymorphisms in women with RPL.
authors.affiliation: Monoclonal Antibody Research Center, Avicenna Research Institute, ACECR, Tehran, Iran. mahjed@yahoo.com
authors.forename: Mahmood
authors.initials: M
authors.lastname: Jeddi-Tehrani
authors.forename: Raheleh
authors.initials: R
authors.lastname: Torabi
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Mohammadzadeh
authors.forename: Soheila
authors.initials: S
authors.lastname: Arefi
authors.forename: Mohammad
authors.initials: M
authors.lastname: Keramatipour
authors.forename: Hojjat
authors.initials: H
authors.lastname: Zeraati
authors.forename: Amir Hasan
authors.initials: AH
authors.lastname: Zarnani
authors.forename: Mohammad Mehdi
authors.initials: MM
authors.lastname: Akhondi
authors.forename: Jafar
authors.initials: J
authors.lastname: Mahmoudian
authors.forename: Ahmad Reza
authors.initials: AR
authors.lastname: Mahmoudi
authors.forename: Saeed
authors.initials: S
authors.lastname: Zarei
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology / Q000235:genetics* / Q000503:physiopathology; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005176:Factor XIII / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007492:Iran; D011110:Polymorphism, Genetic; D011247:Pregnancy; D012307:Risk Factors; D019851:Thrombophilia
chemical_list: D005176:Factor XIII