Calmodulin-an often-ignored signal in osteoclasts.
Calcium signaling plays a key role in bone turnover, regulating both osteoblasts and osteoclasts. Despite this the role of calmodulin, the primary intracellular calcium receptor regulatory protein, has received little attention. In this brief review, the function of Ca(2+)/calmodulin signaling in osteoclast development, function, and apoptosis is reviewed. Considerable evidence supports an important regulatory role for Ca(2+)/calmodulin signaling in each of these processes. The overall role of Ca(2+)/calmodulin in regulating bone turnover is also supported by animal and human studies showing that calmodulin antagonists preserve bone mass.
Williams
John P
JP
National Institute on Aging, Division of Aging Biology, Bethesda, MD, USA. mcdonald@uab.edu
Micoli
Keith
K
McDonald
Jay M
JM
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D050071:Bone Density Conservation Agents / Q000494:pharmacology; D016723:Bone Remodeling / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D002118:Calcium / Q000494:pharmacology; D002147:Calmodulin / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D002454:Cell Differentiation / Q000187:drug effects / Q000235:genetics; D005260:Female; D006801:Humans; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D010052:Ovariectomy; D012377:Rodentia; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics / Q000502:physiology*
D050071:Bone Density Conservation Agents; D002147:Calmodulin; D002118:Calcium
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