Metabolic crossroads of iron and copper.
Interactions between the essential dietary metals, iron and copper, have been known for many years. This review highlights recent advances in iron-copper interactions with a focus on tissues and cell types important for regulating whole-body iron and copper homeostasis. Cells that mediate dietary assimilation (enterocytes) and storage and distribution (hepatocytes) of iron and copper are considered, along with the principal users (erythroid cells) and recyclers of red cell iron (reticuloendothelial macrophages). Interactions between iron and copper in the brain are also discussed. Many unanswered questions regarding the role of these metals and their interactions in health and disease emerge from this synopsis, highlighting extensive future research opportunities.
Collins
James F
JF
Food Science and Human Nutrition Department, University of Florida, Gainesville, Florida 32611, USA.
Prohaska
Joseph R
JR
Knutson
Mitchell D
MD
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003300:Copper / Q000378:metabolism*; D004347:Drug Interactions; D020895:Enterocytes / Q000378:metabolism; D041905:Erythroid Cells / Q000378:metabolism; D022781:Hepatocytes / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism
D003300:Copper; D007501:Iron
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