Glutarimide alkaloids and a terpenoid benzoquinone from Cordia globifera.
Three new compounds, a meroterpene (2) having a cyclopropane moiety named globiferane and glutarimide alkaloids named cordiarimides A (3) and B (4), were isolated from the roots of Cordia globifera. Compounds 2-4 exhibited weak cytotoxic activity. Cordiarimide B (4) exhibited radical scavenging activity, as it inhibited superoxide anion radical formation in the xanthine/xanthine oxidase (XXO) assay, and also suppressed superoxide anion generation in differentiated HL-60 human promyelocytic leukemia cells when induced by 12-O-tetradecanoylphorbol-13-acetate (TPA). This is the first report on the presence of glutarimide alkaloids in the genus Cordia.
Parks
Joshua
J
Chulabhorn Research Institute, Vibhavadi-Rangsit Road, Laksi, Bangkok 10210, Thailand.
Gyeltshen
Thinley
T
Prachyawarakorn
Vilailak
V
Mahidol
Chulabhorn
C
Ruchirawat
Somsak
S
Kittakoop
Prasat
P
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016227:Benzoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031213:Cordia / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D010881:Piperidones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D013481:Superoxides / Q000378:metabolism; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013785:Thailand; D014969:Xanthine Oxidase / Q000187:drug effects / Q000378:metabolism
D000470:Alkaloids; D016227:Benzoquinones; D016166:Free Radical Scavengers; D010881:Piperidones; D013729:Terpenes; C550052:cordiarimide A; C550053:cordiarimide B; C550054:globiferane; D013481:Superoxides; C004532:quinone; D014969:Xanthine Oxidase; D013755:Tetradecanoylphorbol Acetate