title: Life events and risk of subarachnoid hemorrhage: the australasian cooperative research on subarachnoid hemorrhage study (ACROSS).
abstract: OBJECTIVE
  Because little evidence exists and the topic often raises concerns, we aimed to determine the relationship between life events and subarachnoid hemorrhage (SAH) in a population-based case-control setting.
  
  
  METHODS
  In 388 SAH incident cases and 473 frequency-matched community SAH-free control subjects, information on the occurrence of 12 types of adverse life events in the preceding 1 and 2 to 12 months was obtained by interview using a questionnaire based on the Social Behavior Assessment Schedule. Analyses involved logistic regression models with adjustment for confounding variables.
  
  
  RESULTS
  Among 12 life events, only 2 ("financial/legal problems" and "other") in the past month were marginally associated with SAH (P=0.04 and 0.03, respectively), whereas "physical attack/assault" and "injury/disease of a relative/friend/pet" during the past 2 to 12 months also showed similarly marginally significant and imprecise associations (inversely) with SAH. There were no clear associations between multiple life events and SAH for both the prior month and 2 to 12 months (both P>0.4).
  
  
  CONCLUSIONS
  Life events are unlikely to have appreciable effects on the risk of SAH.
authors.affiliation: The George Institute for International Health, Royal Prince Alfred Hospital and the University of Sydney, PO Box M201, Missenden Road, NSW 2050, Australia.
authors.forename: Ivy
authors.initials: I
authors.lastname: Shiue
authors.forename: Hisatomi
authors.initials: H
authors.lastname: Arima
authors.forename: Craig S
authors.initials: CS
authors.lastname: Anderson
mesh_terms: D000328:Adult; D000368:Aged; D001315:Australia / Q000453:epidemiology; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D012307:Risk Factors; D012919:Social Behavior; D013345:Subarachnoid Hemorrhage / Q000453:epidemiology* / Q000209:etiology*; D011795:Surveys and Questionnaires