title: Synthesis and alpha-glucosidase inhibitory activity of oleanolic acid derivatives.
abstract: Glucosidations of oleanolic acid (1) and its dihydroxy-olide derivatives (2) were carried out to provide eight glycosides. All synthesized compounds were evaluated by in vitro alpha-glucosidase inhibitory activity assay. 3-Acetyl dihydroxy-olide oleanolic derivative 15 showed the most potent inhibitory effect. Structure-activity relationships within these compounds are discussed.
authors.affiliation: Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, China.
authors.forename: Shan
authors.initials: S
authors.lastname: Qian
authors.forename: Jiao Hai
authors.initials: JH
authors.lastname: Li
authors.forename: Yu Wei
authors.initials: YW
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Chen
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
mesh_terms: D065089:Glycoside Hydrolase Inhibitors; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D065089:Glycoside Hydrolase Inhibitors; D009828:Oleanolic Acid