Form and function in cell motility: from fibroblasts to keratocytes.
It is plain enough that a horse is made for running, but similar statements about motile cells are not so obvious. Here the basis for structure-function relations in cell motility is explored by application of a new computational technique that allows realistic three-dimensional simulations of cells migrating on flat substrata. With this approach, some cyber cells spontaneously display the classic irregular protrusion cycles and handmirror morphology of a crawling fibroblast, and others the steady gliding motility and crescent morphology of a fish keratocyte. The keratocyte motif is caused by optimal recycling of the cytoskeleton from the back to the front so that more of the periphery can be devoted to protrusion. These calculations are a step toward bridging the gap between the integrated mechanics and biophysics of whole cells and the microscopic molecular biology of cytoskeletal components.
Herant
Marc
M
Biomedical Engineering Department, Boston University, Boston, Massachusetts, USA. herantm@bu.edu
Dembo
Micah
M
D000818:Animals; D001696:Biomechanical Phenomena; D002465:Cell Movement; D048430:Cell Shape; D003599:Cytoskeleton / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology*; D005399:Fishes; D008954:Models, Biological
Exp Cell Res. 1997 Jun 15;233(2):252-73
9194488
PLoS Comput Biol. 2009 Mar;5(3):e1000310
19282961
Multiscale Model Simul. 2005;3(2):413-439
19116671
J Cell Biol. 2006 Sep 11;174(6):767-72
16966418
Nature. 1993 Mar 11;362(6416):167-71
8450887
Biophys J. 1996 Apr;70(4):2008-22
8785360
Nature. 2008 May 22;453(7194):475-80
18497816
Mol Biol Cell. 2005 Feb;16(2):507-18
15548591
Biophys J. 2008 Oct;95(7):3488-96
18599642
Neuron. 1988 Nov;1(9):761-72
3078414
Annu Rev Cell Dev Biol. 2005;21:247-69
16212495
Biophys J. 2007 Dec 1;93(11):3811-9
17704154
Nat Cell Biol. 2007 Mar;9(3):299-309
17310241
Biophys J. 1986 Jul;50(1):109-21
3730497
Biophys J. 2005 Nov;89(5):3589-602
16085776
Mol Biol Cell. 2007 Oct;18(10):3723-32
17634292
Exp Cell Res. 1970 Mar;59(3):393-8
4907703
J Cell Biol. 2005 Feb 14;168(4):619-31
15716379
J Cell Sci. 1995 Jan;108 ( Pt 1):387-93
7738114
J Cell Biol. 1981 Jul;90(1):187-200
7195906
Science. 2003 Mar 14;299(5613):1743-7
12637748
Curr Biol. 1999 Jan 14;9(1):11-20
9889119
J Cell Biol. 2007 Sep 24;178(7):1207-21
17893245
Biophys J. 1993 Jul;65(1):316-24
8369439
Biophys J. 2008 May 1;94(9):3671-83
18199677
Arch Biochem Biophys. 2006 Dec 15;456(2):224-31
17094935
Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9660-5
15210979
J Cell Sci. 2004 May 1;117(Pt 11):2203-14
15126622
J Cell Sci. 2005 May 1;118(Pt 9):1789-97
15827090
J Cell Sci. 1981 Jun;49:1-13
7309801
J Cell Biol. 2007 Feb 26;176(5):573-80
17312025
Science. 2007 Jun 22;316(5832):1753-6
17588932
Semin Cell Dev Biol. 2008 Jun;19(3):215-23
18395478
Science. 2007 Feb 16;315(5814):992-5
17303755
Biophys J. 2003 May;84(5):3389-413
12719267
J Cell Sci. 2006 May 1;119(Pt 9):1903-13
16636075
Science. 2007 Jan 5;315(5808):111-5
17204653
Biophys J. 1999 Apr;76(4):2307-16
10096925
Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14725-30
15377785
PLoS Biol. 2007 Sep;5(9):e233
17760506
Biophys J. 2008 Dec 15;95(12):5508-23
18708450