Echinacea purpurea aerial extract alters course of influenza infection in mice.
Influenza infection is a major clinical problem and Echinacea purpurea, a widely consumed botanical product, is purported to alter the course of respiratory infections including influenza. Mice infected with WSN influenza A and treated with E. purpurea polysaccharide extract had less weight loss than untreated mice but similar pulmonary viral titers. Echinacea-treated mice had lower systemic and pulmonary KC and IL-10 levels and lower systemic IFN-gamma levels following influenza infection. These suggest that E. purpurea alters the clinical course of influenza infection in mice through modulation of cytokines and not direct antiviral activity.
Fusco
Dahlene
D
Division of Infectious Diseases, Weill Cornell Medical College, NY, United States.
Liu
Xinyan
X
Savage
Caroline
C
Taur
Ying
Y
Xiao
Weilie
W
Kennelly
Edward
E
Yuan
Jianda
J
Cassileth
Barrie
B
Salvatore
Mirella
M
Papanicolaou
Genovefa A
GA
D000818:Animals; D001835:Body Weight; D016207:Cytokines / Q000276:immunology; D020900:Echinacea / Q000737:chemistry*; D005260:Female; D053118:Influenza A Virus, H1N1 Subtype; D016753:Interleukin-10 / Q000276:immunology; D008168:Lung / Q000821:virology; D051379:Mice; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D008517:Phytotherapy; D035261:Plant Components, Aerial / Q000737:chemistry; D010936:Plant Extracts / Q000627:therapeutic use*; D011134:Polysaccharides / Q000627:therapeutic use; D019562:Viral Load
D016207:Cytokines; D010936:Plant Extracts; D011134:Polysaccharides; D016753:Interleukin-10
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