title: Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents.
abstract: A series of N-alkyl substituted urea derivatives were synthesized and evaluated for their in vitro antibacterial and antifungal activities. The N-alkyl substituted urea derivatives bearing morpholine moiety (3a-3k) showed better activities than those bearing diethylamine moiety (2a-2f). Compounds having fluoro substituent at ortho (3c) and para (3b) positions of the phenyl ring exhibited potent antimicrobial activities against Gram-positive and Gram-negative bacteria as well as fungi.
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.
authors.forename: Qing-Zhong
authors.initials: QZ
authors.lastname: Zheng
authors.forename: Kui
authors.initials: K
authors.lastname: Cheng
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Zhang
authors.forename: Kai
authors.initials: K
authors.lastname: Liu
authors.forename: Qing-Cai
authors.initials: QC
authors.lastname: Jiao
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Zhu
mesh_terms: D000473:Alkanes / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D014508:Urea / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000473:Alkanes; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D014508:Urea