Object/context-specific memory deficits associated with loss of hippocampal granule cells after adrenalectomy in rats.
Chronic adrenalectomy (ADX) causes a gradual and selective loss of granule cells in the dentate gyrus (DG) of the rat. Here, we administered replacement corticosterone to rats beginning 10 wk after ADX. We then tested them in three discrimination tasks based on object novelty, location, or object/context association. Only during testing of the object/context association did ADX rats demonstrate deficits. These findings add to a body of evidence that the hippocampus is necessary when contextual information is important. We also confirm that memory deficits after chronic adrenalectomy are not a result of loss of corticosterone per se.
Spanswick
Simon C
SC
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge AB T1K 3M4, Canada. simon.spanswick@uleth.ca
Sutherland
Robert J
RJ
D000315:Adrenalectomy / Q000009:adverse effects*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002452:Cell Count / Q000379:methods; D003345:Corticosterone / Q000494:pharmacology; D004193:Discrimination Learning / Q000502:physiology; D005106:Exploratory Behavior / Q000187:drug effects; D006624:Hippocampus / Q000473:pathology*; D007211:Indoles; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D009483:Neuropsychological Tests; D051381:Rats; D013028:Space Perception / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects
D000893:Anti-Inflammatory Agents; D007211:Indoles; C007293:DAPI; D003345:Corticosterone
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