Absence of mutations in GJB2 (Connexin-26) gene in an ethnic group of southwest Iran.
BACKGROUND
The common GJB2 gene mutation (35delG) has been previously reported from Iranian patients that were affected with nonsyndromic autosomal recessive deafness. We, therefore, for the first time, investigated the prevalence and frequency of the GJB2 gene mutation in the Iranian deaf population with Arabian origins.


METHODS
We amplified and sequenced the entire coding sequence of the GJB2 gene from 61 deaf patients and 26 control subjects.


RESULTS
None of the analyzed samples revealed deafness-associated mutation.


CONCLUSIONS
This finding differs from several reports from Iran as we have focused on the GJB2 gene that possesses various mutations as the cause of congenital recessive deafness.
Galehdari
Hamid
H
Department of Genetics, Faculty of Science, Chamran University, Ahwaz, Iran.
Foroughmand
Ali Mohammad
AM
Soorki
Maryam Naderi
MN
Mohammadian
Gholamreza
G
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