title: Detection technologies for Bacillus anthracis: prospects and challenges.
abstract: Bacillus anthracis is a Gram-positive, spore-forming bacterium representing the etiological agent of acute infectious disease anthrax, a lethal but rare disease of animals and humans in nature. With recent use of anthrax as a bioweapon, a number of techniques have been recently developed and evaluated to facilitate its rapid detection of B. anthracis in the environment as well as in point-of-care settings for humans suspected of exposure to the pathogen. Complex laboratory methods for B. anthracis identification are required since B. anthracis has similarities with other Bacillus species and its existence in both spore and vegetative forms. This review discusses current challenges and various improvements associated with anthrax agent detection.
authors.affiliation: Section of Cell Biology, Laboratory of Cellular Hematology, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20892, United States.
authors.forename: Shilpakala Sainath
authors.initials: SS
authors.lastname: Rao
authors.forename: Ketha V K
authors.initials: KV
authors.lastname: Mohan
authors.forename: Chintamani D
authors.initials: CD
authors.lastname: Atreya
mesh_terms: D000818:Animals; D000881:Anthrax / Q000175:diagnosis / Q000382:microbiology*; D001408:Bacillus anthracis / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D001431:Bacteriological Techniques / Q000379:methods*; D019411:Clinical Laboratory Techniques / Q000379:methods*; D006801:Humans