title: Salivary gland function in continuous ambulatory peritoneal dialysis patients by 99mTc-pertechnetate scintigraphy.
abstract: The purpose of this study was to evaluate the alterations in salivary gland function in patients who receiving continuous ambulatory peritoneal dialysis (CAPD) for chronic renal failure (CRF) using technetium-99m pertechnetate ((99m)Tc-P) salivary gland scintigraphy. The study population consisted of 36 CAPD patients (16 males and 20 females, ranging in age from 19 to 73 years, mean age 44.94+/-15.01 years) and 20 healthy controls (11 males and 9 females, ranging in age from 31 to 51 years, mean age 41.25+/-5.62 years). All patients and healthy controls underwent salivary gland scintigraphy. After the intravenous administration of 185MBq of (99m)Tc-P, dynamic salivary gland scintigraphy was performed for 25min. On the basis of the time-activity curves, the following glandular function parameters were calculated for the parotid and submandibular salivary glands: uptake ratio, maximum accumulation, and ejection fraction. Our results showed: All functional parameters obtained for CAPD patients were significantly lower than for healthy controls (P<0.05). In conclusion, this study demonstrated that salivary gland function, an important determinant of oral health, is impaired among the CRF patients treated with CAPD compared with healthy controls, as evaluated by (99m)Tc-P salivary gland scintigraphy.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Ataturk University, Medical School, 25240 Erzurum, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Keles
authors.forename: Bedri
authors.initials: B
authors.lastname: Seven
authors.forename: Erhan
authors.initials: E
authors.lastname: Varoglu
authors.forename: Abdullah
authors.initials: A
authors.lastname: Uyanik
authors.forename: Kerim
authors.initials: K
authors.lastname: Cayir
authors.forename: Arif
authors.initials: A
authors.lastname: Kursad Ayan
authors.forename: Habib
authors.initials: H
authors.lastname: Emre
authors.forename: Ramazan
authors.initials: R
authors.lastname: Cetinkaya
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012469:Salivary Glands / Q000000981:diagnostic imaging*; D012680:Sensitivity and Specificity; D013670:Sodium Pertechnetate Tc 99m; D014987:Xerostomia / Q000000981:diagnostic imaging* / Q000209:etiology*; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m