Regulation of IkappaBalpha function and NF-kappaB signaling: AEBP1 is a novel proinflammatory mediator in macrophages.
NF-kappaB comprises a family of transcription factors that are critically involved in various inflammatory processes. In this paper, the role of NF-kappaB in inflammation and atherosclerosis and the regulation of the NF-kappaB signaling pathway are summarized. The structure, function, and regulation of the NF-kappaB inhibitors, IkappaBalpha and IkappaBbeta, are reviewed. The regulation of NF-kappaB activity by glucocorticoid receptor (GR) signaling and IkappaBalpha sumoylation is also discussed. This paper focuses on the recently reported regulatory function that adipocyte enhancer-binding protein 1 (AEBP1) exerts on NF-kappaB transcriptional activity in macrophages, in which AEBP1 manifests itself as a potent modulator of NF-kappaB via physical interaction with IkappaBalpha and a critical mediator of inflammation. Finally, we summarize the regulatory roles that recently identified IkappaBalpha-interacting proteins play in NF-kappaB signaling. Based on its proinflammatory roles in macrophages, AEBP1 is anticipated to serve as a therapeutic target towards the treatment of various inflammatory conditions and disorders.
Majdalawieh
Amin
A
Department of Biology and Chemistry, Faculty of Arts and Sciences, American University of Sharjah, P.O. Box 26666, Sharjah, UAE. amajdalawieh@aus.edu
Ro
Hyo-Sung
HS
D000595:Amino Acid Sequence; D000818:Animals; D050197:Atherosclerosis / Q000378:metabolism; D002268:Carboxypeptidases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D020672:I-kappa B Proteins / Q000235:genetics / Q000378:metabolism*; D007249:Inflammation / Q000378:metabolism*; D000071518:Liver X Receptors; D008264:Macrophages / Q000276:immunology / Q000502:physiology*; D008969:Molecular Sequence Data; D000072000:NF-KappaB Inhibitor alpha; D016328:NF-kappa B / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D057093:Orphan Nuclear Receptors / Q000378:metabolism; D047495:PPAR gamma / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D016415:Sequence Alignment; D012772:Shock, Septic / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology*
C484818:AEBP1 protein, human; C083487:I kappa B beta protein; D020672:I-kappa B Proteins; D000071518:Liver X Receptors; D016328:NF-kappa B; C000606204:NFKBIA protein, human; D057093:Orphan Nuclear Receptors; D047495:PPAR gamma; D011965:Receptors, Glucocorticoid; D012097:Repressor Proteins; D000072000:NF-KappaB Inhibitor alpha; D002268:Carboxypeptidases
Cell. 1992 Mar 20;68(6):1109-20
1339305
Mol Endocrinol. 2004 Jun;18(6):1376-95
15016838
Mol Cell Biol. 1991 Dec;11(12):5867-77
1944267
Cell. 2004 Sep 17;118(6):671-4
15369667
J Biol Chem. 2001 Mar 30;276(13):10199-206
11152475
EMBO J. 1994 Oct 3;13(19):4597-607
7925300
Mol Cell Biol. 1995 Jun;15(6):3100-9
7760806
J Mol Med (Berl). 2004 Jul;82(7):434-48
15175863
Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7637-41
7644469
J Biol Chem. 2004 Jun 18;279(25):26115-25
15073170
Protein Sci. 1998 Jul;7(7):1626-31
9684896
Science. 1996 Nov 1;274(5288):782-4
8864118
Cell Microbiol. 2008 Sep;10(9):1879-92
18503636
Clin Endocrinol (Oxf). 2005 Mar;62(3):362-5
15730420
Science. 1988 Oct 28;242(4878):540-6
3140380
J Cell Sci. 1997 Feb;110 ( Pt 3):369-78
9057089
J Biol Chem. 1997 Apr 11;272(15):9942-9
9092533
FASEB J. 2000 Nov;14(14):2147-57
11053235
J Biol Chem. 1999 Oct 22;274(43):30353-6
10521409
Endocr Rev. 2003 Aug;24(4):488-522
12920152
Mol Cell Endocrinol. 2009 Feb 27;299(2):219-31
19007848
Curr Opin Immunol. 1999 Feb;11(1):13-8
10047546
Arterioscler Thromb Vasc Biol. 1997 Oct;17(10):1901-9
9351352
Cell. 1994 Oct 7;79(1):13-21
7923371
Mol Endocrinol. 1998 Mar;12(3):355-63
9514153
Mol Cell Biol. 1996 Mar;16(3):1058-65
8622650
J Exp Med. 1998 Jan 19;187(2):147-59
9432973
Nat Cell Biol. 2006 Sep;8(9):986-93
16906147
Annu Rev Immunol. 1994;12:141-79
8011280
Nature. 1998 Sep 17;395(6699):297-300
9751060
Nature. 1995 Nov 2;378(6552):92-6
7477299
Mol Cell Biol. 1995 Mar;15(3):1294-301
7862123
Science. 1995 Oct 13;270(5234):283-6
7569975
Mol Cell. 2002 Mar;9(3):625-36
11931769
J Mol Cell Cardiol. 2001 Apr;33(4):799-810
11273732
J Biol Chem. 1999 Oct 22;274(43):30874-81
10521480
Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2489-93
1532257
Cell. 1995 Apr 21;81(2):149-52
7736567
J Biol Chem. 1995 Jul 14;270(28):17050-5
7622526
Eur J Cell Biol. 2001 Aug;80(8):554-61
11561906
J Biol Chem. 1996 May 3;271(18):10690-6
8631876
Science. 1997 Oct 31;278(5339):866-9
9346485
EMBO J. 1997 Mar 17;16(6):1413-26
9135156
J Biol Chem. 2004 Nov 26;279(48):50050-9
15355994
Exp Cell Res. 1999 Jul 10;250(1):213-22
10388535
Rheumatology (Oxford). 2005 Nov;44(11):1390-3
16159953
Science. 1991 Sep 13;253(5025):1268-71
1891714
Biochim Biophys Acta. 2009 Mar;1792(3):155-62
19162180
Oncogene. 1996 Mar 7;12(5):1159-64
8649809
Genes Dev. 1989 Nov;3(11):1689-98
2691328
J Biol Chem. 2009 May 15;284(20):13686-13695
19297320
Nature. 1995 Jan 26;373(6512):303-10
7530332
J Biol Chem. 2005 Mar 18;280(11):9957-62
15642694
Cell. 1997 Jan 10;88(1):97-107
9019411
Genes Dev. 1992 Sep;6(9):1654-67
1325392
Biochim Biophys Acta. 2009 Mar;1793(3):439-46
19110010
J Nutr. 1999 Nov;129(11):1933-6
10539765
Proc Natl Acad Sci U S A. 1989 Apr;86(8):2839-43
2704749
J Biol Chem. 2001 Apr 20;276(16):12654-9
11124955
Science. 1995 Mar 10;267(5203):1485-8
7878466
Mol Cell. 1998 Apr;1(5):661-71
9660950
Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12740-4
7809113
Blood. 2003 Jun 15;101(12):4667-79
12623839
Oncogene. 2001 Dec 6;20(56):8142-7
11781828
J Biol Chem. 2003 Mar 21;278(12):10443-9
12531895
Nucleic Acids Res. 1993 Nov 11;21(22):5059-66
8255759
Genes Dev. 1993 Nov;7(11):2064-70
8224838
J Thorac Cardiovasc Surg. 2002 Nov;124(5):933-41
12407376
J Biol Chem. 2004 Dec 31;279(53):55633-43
15489227
Cell. 1995 Feb 24;80(4):573-82
7867065
Cell. 1984 Dec;39(3 Pt 2):557-64
6509552
J Biol Chem. 1996 Jan 5;271(1):376-9
8550590
Exp Physiol. 1997 Mar;82(2):297-304
9129944
Am J Physiol Heart Circ Physiol. 2000 Jun;278(6):H2084-93
10843908
J Biol Chem. 1990 Oct 5;265(28):17252-6
2170369
Proc Natl Acad Sci U S A. 1992 May 15;89(10):4333-7
1533932
EMBO J. 1997 Aug 1;16(15):4698-707
9303314
Cell. 1988 Apr 22;53(2):211-7
3129195
Dev Biol. 2007 Jun 1;306(1):160-9
17433289
Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):752-6
8290595
Proc Natl Acad Sci U S A. 1973 Sep;70(9):2554-7
4517669
Genes Dev. 2000 Sep 15;14(18):2314-29
10995388
Biochem J. 1999 Oct 15;343 Pt 2:341-5
10510298
Biochem Biophys Res Commun. 1995 Oct 4;215(1):292-301
7575604
FASEB J. 2007 Jan;21(1):74-80
17099067
Mol Cell Biol. 1999 Sep;19(9):6345-54
10454581
J Biol Chem. 2000 Nov 24;275(47):36703-7
10980195
J Virol. 1993 Jan;67(1):288-93
8416374
J Biol Chem. 2009 Sep 25;284(39):26803-15
19648110
Proc Natl Acad Sci U S A. 1986 Sep;83(18):6800-4
3092220
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3792-7
9520446
Mol Endocrinol. 2005 Apr;19(4):885-97
15591535
Trends Cell Biol. 2000 Apr;10(4):129-33
10740266
Mol Cell Biol. 1995 Oct;15(10):5339-45
7565683
J Clin Invest. 2005 Oct;115(10):2625-32
16200195
EMBO J. 1993 Oct;12(10):3893-901
8404857
EMBO J. 1996 Dec 2;15(23):6716-26
8978697
Diabetes Metab Res Rev. 2008 Feb;24(2):93-102
17990297
Mol Cell Biol. 2001 Feb;21(3):771-80
11154265
Eur J Nutr. 2008 Aug;47(5):235-43
18654736
Cell Metab. 2008 Nov;8(5):372-83
19046569
J Biol Chem. 1995 Feb 17;270(7):3123-31
7852394
Cell. 1992 Mar 20;68(6):1121-33
1547506
Oncogene. 1996 Jun 6;12(11):2425-35
8649784
Mol Cell Biol. 1995 Feb;15(2):872-82
7823953
Cardiovasc Res. 2004 Mar 1;61(4):671-82
14985064
Genes Dev. 1992 Oct;6(10):1899-913
1340770
Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5677-81
8390675
Science. 1998 Aug 28;281(5381):1360-3
9721103
Mol Cell Biol. 2003 Nov;23(21):7780-93
14560022
EMBO J. 2002 Oct 1;21(19):5184-94
12356734
Mol Biol Cell. 2007 Mar;18(3):930-42
17202411
Mol Cell Biol. 1995 Mar;15(3):1302-11
7862124
Invest Ophthalmol Vis Sci. 2007 Mar;48(3):991-1000
17325137
Proc Natl Acad Sci U S A. 1990 Nov;87(21):8417-21
2122462
Arthritis Rheum. 2000 Apr;43(4):801-11
10765924
Trends Biochem Sci. 2005 Jan;30(1):43-52
15653325
J Exp Med. 1998 Jan 19;187(2):185-96
9432976
Toxicology. 2000 Nov 30;155(1-3):27-35
11154794
Mol Cell Biol. 2002 Nov;22(22):7802-11
12391149
Nature. 1995 Jan 26;373(6512):311-7
7830764
Nature. 1992 Sep 24;359(6393):339-42
1406939
Science. 1999 Apr 9;284(5412):309-13
10195894
Nat Immunol. 2002 Jan;3(1):69-75
11743587
Mol Cell Biol. 1996 Oct;16(10):5444-9
8816457
J Immunol. 2008 Jul 1;181(1):235-42
18566389
Cell. 1998 Jun 26;93(7):1231-40
9657155
Proc Natl Acad Sci U S A. 2008 Nov 18;105(46):17818-23
19008357
Semin Cancer Biol. 1997 Apr;8(2):63-73
9299584
Cell Mol Life Sci. 2004 Jul;61(13):1589-95
15224183
Trends Cell Biol. 1992 May;2(5):127-9
14731966
Proc Natl Acad Sci U S A. 2007 Nov 20;104(47):18601-6
18006655
DNA Cell Biol. 1999 Feb;18(2):175-85
10073577
Eur J Biochem. 1998 May 15;254(1):81-9
9652398
J Biol Chem. 1998 Oct 2;273(40):25573-80
9748221
Endocrinology. 2003 Feb;144(2):412-22
12538600
Mol Cell Biol. 1996 Mar;16(3):899-906
8622692
J Neuroimmunol. 1994 Nov;55(1):99-106
7962486
Mol Cell Biol. 1996 Apr;16(4):1295-304
8657102
Mol Cell. 2005 Apr 1;18(1):1-12
15808504
J Biol Chem. 1994 Feb 18;269(7):5387-90
7508937
Am J Physiol. 1996 Jan;270(1 Pt 2):F123-30
8769830
J Biol Chem. 2003 Jan 10;278(2):919-26
12419817
J Clin Invest. 2001 Jul;108(2):203-13
11457873
Semin Cancer Biol. 1997 Apr;8(2):75-82
9299585
Nature. 1998 Jan 1;391(6662):79-82
9422508
J Cell Sci Suppl. 1995;19:79-84
8655651
Biochem Biophys Res Commun. 2009 Apr 17;381(4):477-81
19222990
Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):11884-8
7991551
Mol Cell Biol. 1992 Oct;12(10):4412-21
1406630
Biochem Biophys Res Commun. 2004 Sep 3;321(4):879-85
15358108
Genes Dev. 1995 Nov 15;9(22):2723-35
7590248
EMBO J. 1998 Jan 2;17(1):61-70
9427741
Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):28-32
8278379
Nature. 1993 Sep 9;365(6442):182-5
8371761
J Endotoxin Res. 2000;6(6):453-7
11521070
Nature. 1997 Aug 7;388(6642):548-54
9252186
J Biol Chem. 2006 May 5;281(18):12645-54
16513645
Mol Cell Biol. 1992 Feb;12(2):444-54
1732726
J Biol Chem. 1991 Jan 5;266(1):252-60
1985897
Mol Endocrinol. 1995 Apr;9(4):401-12
7659084
Phytother Res. 2008 Jul;22(7):935-42
18384190
J Immunol. 2009 Sep 1;183(5):3259-67
19641141
Nature. 1990 Apr 12;344(6267):678-82
2157987
J Biol Chem. 2000 Oct 20;275(42):32681-7
10934192
Cell Mol Life Sci. 2007 Aug;64(15):1979-96
17530464
Cardiovasc Res. 2004 Jul 1;63(1):8-10
15194456
Cell Mol Life Sci. 2001 Nov;58(12-13):1790-804
11766880
Mol Cell Biol. 1998 Dec;18(12):7336-43
9819420
Gene. 2001 Dec 12;280(1-2):123-33
11738825
Int Immunopharmacol. 2001 Apr;1(4):625-35
11357875
Cell. 1990 Sep 7;62(5):1019-29
2203532
Adv Immunol. 1995;58:1-27
7741027
Mol Cell Biol. 2000 Sep;20(18):6891-903
10958685
Cell. 1997 Jul 25;90(2):373-83
9244310
Oncogene. 2006 Oct 30;25(51):6717-30
17072324
Oncogene. 2007 Feb 1;26(5):641-51
16862178
Nat Genet. 2004 Aug;36(8):837-41
15247916
Mol Cell Biol. 1999 Feb;19(2):1526-38
9891086
Am J Respir Crit Care Med. 2000 Jan;161(1):224-31
10619824
Arterioscler Thromb Vasc Biol. 1995 Oct;15(10):1591-8
7583532
Science. 1997 Oct 31;278(5339):860-6
9346484
Biochem J. 2004 May 15;380(Pt 1):173-80
14763901
J Rheumatol. 2006 Jul;33(7):1235-9
16821265
Mol Cell Biol. 1998 Jan;18(1):19-29
9418849
Nature. 1990 Mar 1;344(6261):36-42
2137557
Science. 1992 Jun 5;256(5062):1452-6
1604322
Nature. 1999 Mar 18;398(6724):252-6
10094049
Mol Med. 2005 Jan-Dec;11(1-12):39-47
16307171
J Biol Chem. 2003 Aug 22;278(34):31980-7
12791687
J Immunol. 2006 Apr 15;176(8):4666-74
16585559
J Biol Chem. 2001 Jun 1;276(22):18934-40
11259436
Mol Cell Biol. 1995 May;15(5):2413-9
7739525
Biochemistry. 2005 Jan 25;44(3):926-31
15654748
FASEB J. 2007 Sep;21(11):2642-54
17431096
EMBO J. 2003 Aug 1;22(15):3910-8
12881425
Mol Cell Biol. 1996 Jul;16(7):3554-9
8668171
Cell. 2003 Nov 26;115(5):565-76
14651848
Curr Opin Cell Biol. 2008 Jun;20(3):288-93
18468876
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3537-42
9520401
J Biol Chem. 2003 Oct 3;278(40):39242-50
12874295
J Clin Invest. 1993 Jul;92(1):471-8
8392092
J Biol Chem. 1996 Aug 9;271(32):19612-6
8702657
Mol Cell Biol. 1994 May;14(5):2926-35
8164652
EMBO J. 1994 Oct 3;13(19):4608-16
7925301
Biochem Biophys Res Commun. 2000 Jul 14;273(3):1008-14
10891363
DNA Cell Biol. 1998 Oct;17(10):897-909
9809751
J Exp Med. 1997 Mar 3;185(5):953-61
9120401
Cell. 1991 Jun 28;65(7):1281-9
1829648
Obesity (Silver Spring). 2007 Feb;15(2):288-302
17299101
Mol Cell Biol. 1996 May;16(5):2083-90
8628274
J Biol Chem. 2004 Apr 30;279(18):18137-45
14963024
Mol Cell Biol. 1994 Jun;14(6):3915-26
8196632
EMBO J. 1994 Nov 15;13(22):5433-41
7957109
Curr Opin Cell Biol. 1995 Apr;7(2):215-23
7612274
Nature. 1995 Jul 13;376(6536):167-70
7603567
Cancer Res. 2004 Mar 1;64(5):1757-64
14996737
Ann Rheum Dis. 2006 Jun;65(6):791-5
16249223
J Exp Med. 2006 Jan 23;203(1):7-13
16380507
Science. 1999 Apr 9;284(5412):316-20
10195896
Science. 1994 Aug 12;265(5174):966-70
8052857
J Biol Chem. 1999 Jan 29;274(5):2672-81
9915797
Mol Cell Biol. 1995 May;15(5):2689-96
7739549
Int J Biochem Cell Biol. 2009 Jul;41(7):1518-25
19166963
Annu Rev Immunol. 1998;16:225-60
9597130
EMBO J. 1993 Jan;12(1):201-11
7679069
Cell. 1992 Oct 16;71(2):243-53
1423592
EMBO J. 1991 Jul;10(7):1827-32
1675604
Mol Cell Biol. 1997 Aug;17(8):4390-6
9234697
Cell. 1995 Jan 27;80(2):331-40
7834753
J Biol Chem. 1994 May 6;269(18):13551-7
8175790
Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2346-51
16461908
Genes Dev. 2004 Sep 15;18(18):2195-224
15371334
Gene Expr. 1993;3(2):135-50
8268718
EMBO J. 2001 Dec 17;20(24):7168-73
11742993
Mol Cell Biol. 1993 Jun;13(6):3557-66
8497270
J Immunol. 2006 Aug 15;177(4):2527-35
16888014
Nature. 1987 Oct 15-21;329(6140):651-4
2821408
Int J Obes Relat Metab Disord. 2003 Dec;27 Suppl 3:S49-52
14704745
Genes Dev. 1993 Apr;7(4):705-18
8458581
Diabetes. 2005 Dec;54(12):3582-6
16306380
J Biol Chem. 1994 Dec 2;269(48):30089-92
7982908
J Gen Virol. 2008 Aug;89(Pt 8):1881-1889
18632959
Science. 1993 Mar 26;259(5103):1912-5
8096091
Mol Cell Biol. 1995 May;15(5):2809-18
7739562
Genes Dev. 1995 Aug 15;9(16):1965-77
7649478
Cell. 1990 Apr 20;61(2):255-65
2184941
Cell. 1994 Sep 9;78(5):773-85
8087845
Oncogene. 2000 Apr 27;19(18):2224-32
10822372
Am J Pathol. 1990 Sep;137(3):503-9
1698022
Science. 2004 Jun 25;304(5679):1963-7
15218148
Cell. 1997 May 2;89(3):413-24
9150141
J Clin Invest. 1996 Apr 1;97(7):1715-22
8601637
J Biol Chem. 2000 Oct 20;275(42):32592-7
10938077
Cell. 1997 Oct 17;91(2):243-52
9346241
J Exp Med. 1993 Jun 1;177(6):1651-62
8496683
Biochem Biophys Res Commun. 2007 Jun 8;357(3):772-8
17445767
Mol Cell Biol. 1994 Nov;14(11):7226-34
7935437
Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4844-9
10781090
Cell. 1995 Jan 27;80(2):321-30
7834752
J Cell Biol. 1996 Dec;135(6 Pt 1):1457-70
8978815
Mol Cell Biol. 1993 Mar;13(3):1572-82
8441398
Genes Dev. 1995 Jul 1;9(13):1586-97
7628694
J Mol Med (Berl). 2004 Sep;82(9):621-8
15197457
EMBO J. 1999 Jul 15;18(14):4004-12
10406805
Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):11259-63
7479976
EMBO J. 2001 Dec 17;20(24):7108-16
11742987
Biochem J. 2004 Jul 15;381(Pt 2):547-59
15084145
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):986-91
12552083
J Immunol. 2001 Aug 1;167(3):1592-600
11466381
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2994-9
10077625
Curr Biol. 1998 Jan 1;8(1):R19-22
9427616
Mol Pharmacol. 2002 Jan;61(1):177-85
11752219
J Clin Invest. 2001 Jan;107(2):135-42
11160126
J Biol Chem. 2002 Jul 19;277(29):26238-43
12011091
Mol Cell Biol. 1991 Sep;11(9):4732-8
1875949
Mol Cell. 1998 Aug;2(2):233-9
9734360
Science. 1999 Jan 22;283(5401):543-6
9915703
Proc Natl Acad Sci U S A. 1996 Apr 16;93(8):3308-12
8622934
J Exp Med. 1999 Jun 7;189(11):1839-45
10359587
Eur J Pharmacol. 2001 Oct 19;429(1-3):327-34
11698053
EMBO J. 1999 Dec 1;18(23):6682-93
10581242
J Clin Endocrinol Metab. 2006 Aug;91(8):3138-43
16735488
Nat Med. 2003 Feb;9(2):213-9
12524534
Mol Endocrinol. 2009 Jan;23(1):86-99
18945810
Mol Cell Biol. 1999 Jul;19(7):4798-805
10373529
Mol Cell Biol. 1993 Dec;13(12):7826-35
8246997
J Rheumatol. 2006 Jun;33(6):1048-51
16755651
Mol Cell Biol. 1994 Nov;14(11):7377-84
7935451
Science. 1991 Feb 15;251(4995):788-91
1990440
Mol Cell Biol. 1999 Jul;19(7):4547-51
10373503
J Exp Med. 1991 Dec 1;174(6):1517-26
1744583
Mol Cell. 2004 May 7;14(3):303-17
15125834
Mol Cell Biol. 1996 Dec;16(12):6736-43
8943328
Annu Rev Immunol. 1996;14:649-83
8717528
Proc Natl Acad Sci U S A. 1988 Jul;85(13):4700-4
3133660
Proc Natl Acad Sci U S A. 1999 Jan 5;96(1):49-54
9874770
Genes Dev. 1992 May;6(5):775-87
1577272
J Ethnopharmacol. 2007 Dec 3;114(3):316-24
17931811
Mol Cell Biol. 1996 Apr;16(4):1401-9
8657113
Cell. 1986 Aug 29;46(5):705-16
3091258
J Biol Chem. 2005 Jul 29;280(30):27783-91
15917220
Biochim Biophys Acta. 2004 Nov 29;1695(1-3):113-31
15571812
Proc Natl Acad Sci U S A. 2003 May 27;100(11):6712-7
12740443
Biochem J. 1994 Oct 15;303 ( Pt 2):499-506
7980409
Microbiol Mol Biol Rev. 2004 Jun;68(2):320-44
15187187
J Biol Chem. 2000 Aug 11;275(32):24383-91
10823840
Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10599-603
7479848
J Clin Invest. 2001 Jan;107(1):7-11
11134171
Planta Med. 2009 Jan;75(1):7-11
19003727
Science. 1995 Oct 13;270(5234):286-90
7569976
EMBO J. 2003 Mar 17;22(6):1313-24
12628924
Oncogene. 1993 Aug;8(8):2067-73
8336935
Mol Cell Biol. 1995 Feb;15(2):943-53
7823959
EMBO J. 1995 Jun 15;14(12):2876-83
7796813
Cell. 1998 May 15;93(4):531-41
9604929
Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):552-6
7831327
J Mol Cell Cardiol. 2001 Feb;33(2):283-94
11162133
Nature. 1993 Apr 29;362(6423):801-9
8479518
Can J Physiol Pharmacol. 2008 Nov;86(11):777-84
19011673
Mol Biol Cell. 1992 Dec;3(12):1339-52
1493333