title: Initial experience with 18F-fluoroethylcholine PET/CT in staging  and monitoring therapy response of advanced renal cell  carcinoma.
abstract: OBJECTIVE
  The use of 18F-fluoroethylcholine (FEC) PET/ CT in staging and monitoring therapy response of advanced renal cell carcinoma (RCC) was prospectively analysed.
  
  
  METHODS
  Preliminary results of two patients with metastatic RCC who underwent tumour nephrectomy as well as FEC PET/CT before and 10 weeks after two cycles of tyrosine kinase inhibitor therapy are presented.
  
  
  RESULTS
  All in all, 18 tumour lesions were detected by baseline PET/CT, of which 10 (56%) were positive in FEC PET and 17 (94%) visible on contrast-enhanced computed tomography (ceCT). Mainly, small lung metastases resulted in the lower detection rate of FEC PET compared with ceCT. In follow-up PET/CT of the first case, progressive disease (PD) occurred with increase in tumour diameters of all metastases but non-uniform metabolic response. In the second case, partial response (PR) was achieved with concordant results of PET and CT. These results were confirmed by further CT in the course of disease.
  
  
  CONCLUSIONS
  In this small sample more than half of the RCC metastases were evident in baseline FEC PET. Monitoring therapy, FEC PET showed heterogeneous results in the first case with PD and was consistent with ceCT in the second one displaying PR.
authors.affiliation: Department of Nuclear Medicine, Hospital of JW Goethe University, Theodor-Stern-Kai 7, 60590 Frankfurt am Main, Germany. marcus.middendorp@kgu.de
authors.forename: Marcus
authors.initials: M
authors.lastname: Middendorp
authors.forename: Luise
authors.initials: L
authors.lastname: Maute
authors.forename: Bruno
authors.initials: B
authors.lastname: Sauter
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Vogl
authors.forename: Frank
authors.initials: F
authors.lastname: Grünwald
mesh_terms: D000368:Aged; D002292:Carcinoma, Renal Cell / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D002794:Choline / Q000031:analogs & derivatives*; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis* / Q000473:pathology* / Q000628:therapy; D008297:Male; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: C448902:fluoroethylcholine; D002794:Choline