[Mantoux versus immunoferon-gamma test for diagnosis of latent tuberculosis infection in TB patient contacts].
OBJECTIVE
To compare the sensitivity, specificity and efficiency between Mantoux and Interferon-gamma techniques, using secondary sources.


METHODS
Study of the published literature with a high evidence-based sources of scientific information.


METHODS
A bibliographic search in the Cochrane database and Trip-database.


METHODS
We found three Clinical Practice Guidelines and nine articles, which included one Systematic Review, one Meta-analysis, one article on the sensitivity of the new techniques, three cost-efficiency studies, and three prospective studies on the role of interferon-gamma release in the diagnosis of TB.


RESULTS
The new techniques have a higher specificity than Mantoux for the diagnosis of LTBI in contacts vaccinated in childhood with BCG. The most cost-effective diagnostic strategy for LTBI was Mantoux screening and confirmation with QFT-G.


CONCLUSIONS
Resources should be coordinated, limiting its use in studies of contacts in immunocompetent adults vaccinated with BCG, with Mantoux>5mm or Tuberculin doubtful cases.
Fernández Arias
Antonio
A
Medicina Familiar y Comunitaria, Unidad de Gestión Clínica Algeciras Sur, Área Sanitaria Campo de Gibraltar, Cádiz, Spain. afdzarias@hotmail.com
D000276:Adjuvants, Immunologic; D002130:Calcium Phosphates; D006020:Glycopeptides; D006801:Humans; D055985:Latent Tuberculosis / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D014374:Tuberculin Test
D000276:Adjuvants, Immunologic; D002130:Calcium Phosphates; D006020:Glycopeptides; C038773:Immunoferon
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