title: Oxepinochromenones, furochromenone, and their putative precursors from the endolichenic fungus Coniochaeta sp.
abstract: Six new polyketides including four oxepinochromenones, conioxepinols A-D (1-4), one furochromenone, coniofurol A (5), and one xanthone, conioxanthone A (6), have been isolated from the crude extract of the endolichenic fungus Coniochaeta sp. The absolute configurations of C-7 in 1 and the 7,8-diol moiety in 3 were assigned using the modified Mosher's and Snatzke's method, respectively, whereas that of C-8 in 5 was deduced via the circular dichroism data of the [Rh(2)(OCOCF(3))(4)] complex. Compounds 2-4 showed modest cytotoxicity against a small panel of human tumor cell lines.
authors.affiliation: Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
authors.forename: Yinchao
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Zheng
authors.forename: Shuchun
authors.initials: S
authors.lastname: Liu
authors.forename: Hua
authors.initials: H
authors.lastname: Zhang
authors.forename: Erwei
authors.initials: E
authors.lastname: Li
authors.forename: Liangdong
authors.initials: L
authors.lastname: Guo
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008011:Lichens / Q000382:microbiology; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins