title: Possible involvement of signal transducers and activators of transcription 3 system on depression in the model mice brain.
abstract: The aim of this study was to examine gene expression changes in the frontal cortex and hippocampus of animals with different susceptibility to stressful stimuli. Using a learned helplessness (LH) paradigm, mice received moderate current stimulation to induce different extents of LH behavior. Changes in mRNA expression were investigated by microarray and semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). Comparisons of expression profiles between LH and control or non-learned helplessness (non-LH) animals revealed that the signal transducers and activators of transcription 3 (Stat3)-interacting protein (StIP1) gene is downregulated in LH animals and the suppressor of cytokine signaling 3 (Socs3) gene is up-regulated in non-LH animals. Since both StIP1 and Socs3 regulate the activity of Stat3 gene, these results suggest that Stat3 systems may be involved in the pathogenesis of depressive disorders.
authors.affiliation: Division of Medicinal Pharmacology, Institute of Natural Medicine, University of Toyama, Japan.
authors.forename: Salin
authors.initials: S
authors.lastname: Mingmalairak
authors.forename: Michihisa
authors.initials: M
authors.lastname: Tohda
authors.forename: Yukihisa
authors.initials: Y
authors.lastname: Murakami
authors.forename: Kinzo
authors.initials: K
authors.lastname: Matsumoto
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D003863:Depression / Q000209:etiology / Q000235:genetics*; D004195:Disease Models, Animal; D015870:Gene Expression; D005796:Genes; D020022:Genetic Predisposition to Disease; D006380:Helplessness, Learned; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D050796:STAT3 Transcription Factor / Q000235:genetics* / Q000378:metabolism; D015398:Signal Transduction / Q000235:genetics*; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation
chemical_list: D012333:RNA, Messenger; D050796:STAT3 Transcription Factor; D050826:Suppressor of Cytokine Signaling Proteins