Developing and evaluating comprehensive HIV infection control strategies: issues and challenges.
As described elsewhere in this supplement, development of effective methods for prevention of human immunodeficiency virus (HIV) infection has proven to be more challenging than development of effective treatment for the disease. New strategies to control the HIV epidemic are urgently needed; this urgency creates interest in investigation of the possibility of using antiretroviral treatment in combination with other modalities to control the epidemic. This article summarizes current knowledge concerning prevention modalities in the context of the drivers of the HIV epidemic in specific communities, describes challenges in investigating test-and-treat strategies, and proposes research directions for addressing these challenges to investigate the impact of prevention strategies on mitigation of epidemics.
DeGruttola
Victor
V
Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA. victor@sdac.harvard.edu
Smith
Davey M
DM
Little
Susan J
SJ
Miller
Veronica
V
D003140:Communicable Disease Control / Q000379:methods*; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control*; D006302:Health Services Research / Q000379:methods*; D006801:Humans
Reprod Health Matters. 2007 May;15(29):62-7
17512377
HIV Med. 2007 Sep;8(6):382-7
17661846
Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11236-40
1763038
J Virol. 2007 Dec;81(23):13050-6
17898057
PLoS One. 2008 May 21;3(5):e2212
18493593
AIDS. 2009 Jan 14;23(2):225-32
19098493
PLoS Med. 2009 Sep;6(9):e1000109
19901974
Am J Obstet Gynecol. 2007 Sep;197(3 Suppl):S42-55
17825650
Sex Transm Infect. 2002 Dec;78(6):448-51
12473809
Public Health Rep. 1998 Jun;113 Suppl 1:75-80
9722812
AIDS. 2006 Apr 4;20(6):923-8
16549978
Science. 1992 May 22;256(5060):1165-71
1589796
PLoS Clin Trials. 2007 May 25;2(5):e27
17525796
AIDS. 1997 Apr;11(5):641-8
9108946
J Infect Dis. 2005 May 1;191(9):1403-9
15809897
J Virol. 1997 Sep;71(9):6348-58
9261352
BMJ. 2009 Apr 30;338:b1649
19406887
N Engl J Med. 2008 Aug 28;359(9):888-90
18753644
Focus. 2007 May;22(5):1-4
18333632
Drug Alcohol Depend. 2009 Apr 1;101(1-2):101-6
19117698
Clin Infect Dis. 2010 May 15;50 Suppl 3:S85-95
20397961
AIDS. 2006 Mar 21;20(5):731-9
16514304
J Infect Dis. 2007 Apr 1;195(7):951-9
17330784
Curr Opin Infect Dis. 2006 Feb;19(1):1-7
16374210
AIDS Rev. 2006 Jul-Sep;8(3):125-40
17078483
Contemp Clin Trials. 2007 Feb;28(2):182-91
16829207
Lancet. 2007 Feb 24;369(9562):657-66
17321311
Curr Opin Infect Dis. 2008 Dec;21(6):644-52
18978533
Lancet. 2008 Jun 21;371(9630):2064-5
18572064
Science. 2004 Jan 16;303(5656):327-32
14726583
PLoS Med. 2005 Nov;2(11):e298
16231970
PLoS Med. 2006 Jul;3(7):e262
16822094
AIDS. 2008 Jul;22 Suppl 1:S67-74
18664956
J Int AIDS Soc. 2009 May 27;12:7
19473540
Am J Obstet Gynecol. 2007 Sep;197(3 Suppl):S26-32
17825647
N Engl J Med. 2005 Feb 10;352(6):570-85
15703422
Lancet. 2008 Sep 6;372(9641):831-44
18687457
Nature. 2006 Dec 14;444(7121):836-7
17171825
Cochrane Database Syst Rev. 2009 Jan 21;(1):CD007189
19160329
J Infect Dis. 2006 Jan 1;193(1):16-26
16323127
Am J Mens Health. 2008 Sep;2(3):291-5
19477792
J Immigr Minor Health. 2009 Feb;11(1):1-6
18247117
Curr HIV Res. 2009 May;7(3):279-86
19442123
AIDS Behav. 2009 Aug;13(4):615-29
19205867
Cochrane Database Syst Rev. 2008 Jul 16;(3):CD001230
18646068
Microbes Infect. 2003 Feb;5(2):189-96
12650777
J Acquir Immune Defic Syndr. 2004 Nov 1;37(3):1404-14
15483470
Cochrane Database Syst Rev. 2001;(3):CD003255
11687062
J Acquir Immune Defic Syndr. 2009 May 1;51 Suppl 1:S21-5
19384097
MMWR Morb Mortal Wkly Rep. 1994 May 20;43(19):347, 353-6
8177193
AIDS. 2009 Jun 19;23(10):1277-84
19440142
N Engl J Med. 2000 Mar 30;342(13):921-9
10738050
Sex Transm Dis. 2009 May;36(5):284-9
19295472
Lancet. 2007 Feb 24;369(9562):643-56
17321310
Stud Fam Plann. 2008 Dec;39(4):295-308
19248716
Science. 2001 May 11;292(5519):1106-9
11352065
J Exp Med. 2001 Jan 15;193(2):169-80
11148221
J R Soc Interface. 2005 Sep 22;2(4):295-307
16849187
PLoS Med. 2008 Mar 25;5(3):e71
18366249
Sex Transm Infect. 2009 Oct;85(6):420-6
19188211
PLoS Med. 2008 Mar 18;5(3):e50
18351795
J Acquir Immune Defic Syndr. 2009 Aug 15;51(5):593-600
19421070
BMJ. 2001 Nov 17;323(7322):1174-7
11711413
Am J Public Health. 2009 Jun;99(6):1093-9
19372521