Solid focal liver lesions: dynamic and late enhancement patterns with the dual phase contrast agent gadobenate dimeglumine.
BACKGROUND
The purpose of this paper is to illustrate contrast enhancement patterns of solid focal liver lesions on dynamic and late phase imaging with gadobenate dimeglumine (Gd-BOPTA).


RESULTS
Unenhanced T2- and T1-weighted, dynamic T1-weighted (arterial, portal-venous, and equilibrium) and late phase (1-3 h) Gd-BOPTA-enhanced MR imaging of different focal liver lesions (nodular regenerative hyperplasia, hepatic adenoma, liver adenomatosis, hepatocellular carcinoma, peripheral cholangiocarcinoma, hypervascular metastases, and hypovascular metastases) are shown. Dynamic imaging was performed using GRE T1-w sequences after the bolus injection of 0.1 mmol/kg Gd-BOPTA; late-phase imaging was obtained at 1-3 h after contrast injection.


CONCLUSIONS
Dynamic imaging with Gd-BOPTA provides the same information as with conventional gadolinium-based extracellular contrast agents, while late-phase imaging gives additional information for lesion identification and characterization.
Grazioli
Luigi
L
Department of Radiology, University of Brescia, Brescia, Italy. lgrazioli@yahoo.com
Bondioni
Maria Pia
MP
Faccioli
Niccolò
N
Gambarini
Sebastiana
S
Tinti
Rita
R
Schneider
Günther
G
Kirchin
Miles
M
D003287:Contrast Media; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D008107:Liver Diseases / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008536:Meglumine / Q000031:analogs & derivatives*; D009942:Organometallic Compounds
D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine
J Comput Assist Tomogr. 1999 Sep-Oct;23(5):670-7
10524843
AJR Am J Roentgenol. 2000 Oct;175(4):1111-20
11000175
AJR Am J Roentgenol. 2002 Apr;178(4):877-83
11906867
Radiology. 2001 Dec;221(3):731-9
11719669
J Magn Reson Imaging. 1999 May;9(5):704-10
10331767
Hepatogastroenterology. 2001 Sep-Oct;48(41):1425-9
11677979
Eur Radiol. 2001;11(8):1374-88
11519546
J Pediatr Gastroenterol Nutr. 1997 Mar;24(3):276-9
9138172
Prog Liver Dis. 1996;14:265-78
9055582
Magn Reson Imaging Clin N Am. 1997 May;5(2):319-30
9113677
Hepatology. 1995 Dec;22(6):1674-81
7489973
AJR Am J Roentgenol. 2001 Jun;176(6):1499-507
11373220
Acad Radiol. 1998 Apr;5 Suppl 1:S86-9; discussion S93-4
9561052
Radiology. 2005 Jul;236(1):166-77
15955857
J Magn Reson Imaging. 2003 May;17(5):593-602
12720270
Radiology. 1996 May;199(2):513-20
8668804
Radiology. 1994 Aug;192(2):393-9
8029403
Invest Radiol. 2000 Jan;35(1):25-34
10639033
Invest Radiol. 1998 Nov;33(11):798-809
9818314
Semin Liver Dis. 1987 Aug;7(3):257-68
3317862
J Comput Assist Tomogr. 1997 Jan-Feb;21(1):59-65
9022771
Invest Radiol. 2003 Feb;38(2):85-94
12544071
AJR Am J Roentgenol. 2004 May;182(5):1217-23
15100122
Invest Radiol. 2001 Nov;36(11):632-41
11606840
Cancer. 1986 Jul 15;58(2):321-8
3013389
Radiology. 1994 Nov;193(2):507-12
7972769
Radiology. 2000 Jun;215(3):727-36
10831691
Invest Radiol. 2006 Mar;41(3):222-8
16481904
Invest Radiol. 1997 Dec;32(12):780-96
9406019
Dig Dis Sci. 1992 Jul;37(7):1105-9
1618060
AJR Am J Roentgenol. 1993 Jun;160(6):1177-87
8388618
Eur Radiol. 2005 Feb;15(2):220-8
15624108
Eur Radiol. 2004 Jan;14(1):5-13
14600778
Hepatology. 1990 May;11(5):787-97
2189821
J Comput Assist Tomogr. 1999 Nov;23 Suppl 1:S161-8
10608412
Hepatology. 1985 Nov-Dec;5(6):1194-200
4065824
Acad Radiol. 1999 May;6(5):282-91
10228617
J Magn Reson Imaging. 1995 Mar-Apr;5(2):165-70
7766977
Hum Pathol. 1991 Feb;22(2):172-8
1848205
J Hepatol. 2001 Sep;35(3):421-30
11592607
Invest Radiol. 2006 Mar;41(3):213-21
16481903
Ann Surg. 1988 Nov;208(5):558-64
3190282
Radiol Clin North Am. 1994 Jan;32(1):39-54
8284360