title: Gender differences of low-dose aspirin-associated gastroduodenal ulcer in Japanese patients.
abstract: OBJECTIVE
  To clarify the gender differences about the clinical features and risk factors of low-dose aspirin (LDA) (81-100 mg daily)-associated peptic ulcer in Japanese patients.
  
  
  METHODS
  There were 453 patients under treatment with LDA (298 males, 155 females) who underwent esophagogastroduodenoscopy at the Department of Gastroenterology and Hepatology of Hiratsuka City Hospital between January 2003 and December 2007. They had kept taking the LDA or started treatment during the study period and kept taking LDA during the whole period of observation. Of these, 119 patients (87 males, 32 females) were diagnosed as having LDA-associated peptic ulcer. We examined the clinical factors associated with LDA-associated peptic ulcer in both sexes.
  
  
  RESULTS
  A history of peptic ulcer was found to be the risk factor for LDA-associated peptic ulcer common to both sexes. In female patients, age greater than 70 years (prevalence ORs 8.441, 95% CI: 1.797-33.649, P = 0.0069) was found to be another significant risk factor, and the time to diagnosis as having LDA-associated peptic ulcer by endoscopy was significantly shorter than that in the male patients (P = 0.0050).
  
  
  CONCLUSIONS
  We demonstrated gender differences about the clinical features and risk factors of LDA-associated peptic ulcer. Special attention should be paid to aged female patients taking LDA.
authors.affiliation: Department of Gastroenterology and Hepatology, Hiratsuka City Hospital, 1-19-1, Nanbara, Hiratsuka 254-0066, Japan.
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Okada
authors.forename: Masahiko
authors.initials: M
authors.lastname: Inamori
authors.forename: Kento
authors.initials: K
authors.lastname: Imajyo
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Chiba
authors.forename: Takashi
authors.initials: T
authors.lastname: Nonaka
authors.forename: Tadahiko
authors.initials: T
authors.lastname: Shiba
authors.forename: Takashi
authors.initials: T
authors.lastname: Sakaguchi
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Atsukawa
authors.forename: Hisao
authors.initials: H
authors.lastname: Takahashi
authors.forename: Etsuo
authors.initials: E
authors.lastname: Hoshino
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000009:adverse effects*; D004724:Endoscopy / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010437:Peptic Ulcer / Q000175:diagnosis / Q000209:etiology*; D012307:Risk Factors; D012737:Sex Factors
chemical_list: D001241:Aspirin
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