title: Two cases of statin-induced rhabdomyolysis associated with mononeuropathy.
abstract: HMG-CoA reductase inhibitors (statins) are highly effective drugs for prevention of cardiovascular events in high-risk patients. Due to the widespread prescription of these agents, special attention should be given to their rare adverse effects when these may have severe outcomes. Here, we report two cases of localized rhabdomyolysis associated with mononeuropathy in patients taking statins and suggest possible explanations for this uncommon association. Close monitoring for myopathic/neuropathic events is warranted in high-risk patients with pre-existing neuropathies who are taking statins.
authors.affiliation: Department of Clinical and Experimental Medicine, University of Padova, Medical School, Padova, Italy. gianpaolofadini@hotmail.com
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Fadini
authors.forename: Enzo
authors.initials: E
authors.lastname: Manzato
authors.forename: Cristina
authors.initials: C
authors.lastname: Crepaldi
authors.forename: Saula
authors.initials: S
authors.lastname: de Kreutzenberg
authors.forename: Antonio
authors.initials: A
authors.lastname: Tiengo
authors.forename: Angelo
authors.initials: A
authors.lastname: Avogaro
mesh_terms: D000328:Adult; D016903:Drug Monitoring; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D020422:Mononeuropathies / Q000139:chemically induced* / Q000209:etiology; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000209:etiology; D012307:Risk Factors
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors
references.citation: Nutr Metab Cardiovasc Dis. 2007 Jan;17(1):32-40
references.pmid: 17174224
references.citation: Drugs Today (Barc). 2005 Apr;41(4):267-93
references.pmid: 16034491
references.citation: Arch Intern Med. 2004 Jul 12;164(13):1427-36
references.pmid: 15249352
references.citation: Atherosclerosis. 2007 Nov;195(1):7-16
references.pmid: 17094994
references.citation: Arch Intern Med. 2006 Jul 24;166(14):1519-24
references.pmid: 16864763
references.citation: Arch Intern Med. 2005 Apr 11;165(7):725-30
references.pmid: 15824290
references.citation: Am J Cardiol. 2006 Apr 17;97(8A):52C-60C
references.pmid: 16581329
references.citation: Am J Med. 2006 May;119(5):400-9
references.pmid: 16651050