title: Synthesis and preliminary biological evaluation of chrysin derivatives as potential anticancer drugs.
abstract: A series of chrysin derivatives were prepared from 2-hydroxyacetophenone, 2,4-dihydroxyacetophenone, 2,4,6-trihydroxy- acetophenone, using modified Baker-Venkataraman transformation. Their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of chrysin derivatives showed stronger anticancer activity than 5-fluorouracil.
authors.affiliation: Institute of Pharmacy & Pharmacology, University of South China, Hengyang, 421001, China. zhengxing5018@yahoo.com
authors.forename: Xing
authors.initials: X
authors.lastname: Zheng
authors.forename: Fei Fei
authors.initials: FF
authors.lastname: Zhao
authors.forename: Yun Mei
authors.initials: YM
authors.lastname: Liu
authors.forename: Xu
authors.initials: X
authors.lastname: Yao
authors.forename: Zi Tong
authors.initials: ZT
authors.lastname: Zheng
authors.forename: Xing
authors.initials: X
authors.lastname: Luo
authors.forename: Duan Fang
authors.initials: DF
authors.lastname: Liao
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50
chemical_list: D000970:Antineoplastic Agents; D005419:Flavonoids; C043561:chrysin