title: PROTIS: use of combined biomarkers for providing diagnostic information on disease states.
abstract: We describe herein PROTIS, a software package that allows for the combination of urine biomarkers (proteins, small molecules, cells) to provide accurate diagnostic information on renal disease states. Such an approach exemplifies the advantage conferred by using multiple markers, and can be generalized for identification of biomarker signatures to separate distinct sample groups.
authors.affiliation: Institüt für Klinische Chemie, Städtisches Klinikum München GmbH, München, Germany.
authors.forename: Walter
authors.initials: W
authors.lastname: Hofmann
authors.forename: Cornelia
authors.initials: C
authors.lastname: Sedlmeir-Hofmann
authors.forename: Miroslav
authors.initials: M
authors.lastname: Ivandić
authors.forename: Dagmar
authors.initials: D
authors.lastname: Ruth
authors.forename: Peter
authors.initials: P
authors.lastname: Luppa
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood / Q000652:urine; D055316:Cystatin C / Q000097:blood; D003937:Diagnosis, Differential; D005260:Female; D005919:Glomerular Filtration Rate; D006417:Hematuria / Q000175:diagnosis / Q000652:urine; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007674:Kidney Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology / Q000652:urine; D008297:Male; D011507:Proteinuria / Q000378:metabolism; D012984:Software; D055815:Young Adult
chemical_list: D015415:Biomarkers; D055316:Cystatin C; D003404:Creatinine