title: Monte Carlo single-cell dosimetry of Auger-electron emitting radionuclides.
abstract: A hybrid Monte Carlo transport scheme combining event-by-event and condensed-history simulation with a full account of energy-loss straggling was used to study the dosimetric characteristics of the Auger-emitting radionuclides 67Ga, 99mTc, 111In, 123I, 125I and 201Tl at the single-cell level. The influence of the intracellular localization of the Auger radionuclide upon cellular S-values, radial dose rate profiles and dose-volume-histograms (DVHs) was investigated. For the case where the radiopharmaceutical was either internalized into the cytoplasm or remained bound onto the cell surface (non-internalized), the dose to the cell nucleus was found to differ significantly from the MIRD values and other published data. In this case, the assumption of a homogeneous distribution throughout the cell is shown to significantly overestimate the nuclear dose. A dosimetric case study relevant to the radioimmunotherapy of single lymphoma B-cells with 125I and 123I is presented.
authors.affiliation: Department of Medical Physics, University of Ioannina, Ioannina 45110, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Bousis
authors.forename: D
authors.initials: D
authors.lastname: Emfietzoglou
authors.forename: P
authors.initials: P
authors.lastname: Hadjidoukas
authors.forename: H
authors.initials: H
authors.lastname: Nikjoo
mesh_terms: D000911:Antibodies, Monoclonal; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000528:radiation effects; D004583:Electrons; D006801:Humans; D016393:Lymphoma, B-Cell / Q000473:pathology / Q000532:radiotherapy; D009010:Monte Carlo Method; D011829:Radiation Dosage; D011868:Radioisotopes / Q000627:therapeutic use*; D011874:Radiometry / Q000379:methods*
chemical_list: D000911:Antibodies, Monoclonal; D011868:Radioisotopes