title: Comparison of efficacy of ivermectin and doramectin against mange mite (Sarcoptes scabiei) in naturally infested rabbits in Turkey.
abstract: The authors used 14 New Zealand rabbits (5 naturally infested rabbits and 9 in-contact rabbits) for Sarcoptes scabiei treatment in this study. Signs, such as itchy ears, eyes, tail and abdominal skin, alopecia and pyoderma, were considered to be the cause of these disorders. Infested rabbits were grouped according to the intensity of S. scabiei infestation (low, medium and high). Each group was then divided into two subgroups; in one subgroup the rabbits received ivermectin (1%) and, in the other, doramectin (1%). All subgroups received a subcutaneous injection at a dosage of 400 microg/kg body weight every 80 h on three occasions. On day 28 after commencing the treatment, all the rabbits in the first two groups had recovered completely. Although both drugs were applied at the same time and at the same dose, the third group (high degree of infestation), revealed, both microscopically and macroscopically, that ivermectin has more rapid effect than doramectin. Treatment was effective in all groups.
authors.affiliation: Department of Laboratory Animal Science, Faculty of Medicine, Dokuz Eylul University, Inciralti, 35340 Izmir, Turkey.
authors.forename: Dürdane
authors.initials: D
authors.lastname: Kaya
authors.forename: Tonay
authors.initials: T
authors.lastname: Inceboz
authors.forename: Efsun
authors.initials: E
authors.lastname: Kolatan
authors.forename: Ensari
authors.initials: E
authors.lastname: Güneli
authors.forename: Osman
authors.initials: O
authors.lastname: Yilmaz
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D007559:Ivermectin / Q000008:administration & dosage* / Q000031:analogs & derivatives*; D008924:Mite Infestations / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D011817:Rabbits / Q000469:parasitology*; D012520:Sarcoptes scabiei; D012876:Skin Diseases, Parasitic / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D014421:Turkey
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin; C084101:doramectin