PET designated flouride-18 production and chemistry.
Positron emission tomography (PET) is a nuclear medicine imaging technology which allows for four-dimensional, quantitative determination of the distribution of labeled biological compounds within the human body. PET is becoming an increasingly important tool for the measurement of physiological, biochemical and pharmacological functions at the molecular level in healthy and pathological conditions. This review will focus on Flouride-18, one of the common isotopes used for PET imaging, which has a half life of 109.8 minutes. This isotope can be produced with an efficient yield in a cyclotron as a nucleophile or as an electrophile. Flouride-18 can be thereafter introduced into small molecules or biomolecules using various chemical synthetic routes, to give the desired imaging agent.
Jacobson
Orit
O
Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
Chen
Xiaoyuan
X
D019788:Fluorodeoxyglucose F18 / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D015336:Molecular Probe Techniques; D009369:Neoplasms / Q000175:diagnosis*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000737:chemistry*
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
J Nucl Med. 2007 Sep;48(9):1536-44
17704249
Appl Radiat Isot. 1993 Aug;44(8):1085-91
8358398
Int J Appl Radiat Isot. 1977 Jan-Feb;28(1-2):53-65
323160
J Urol. 2006 Sep;176(3):940-4; discussion 944
16890661
Int J Appl Radiat Isot. 1985 Apr;36(4):318-9
4018894
Appl Radiat Isot. 2001 Jan;54(1):73-80
11144255
Nucl Med Biol. 2003 May;30(4):345-50
12767390
J Nucl Med. 1987 Apr;28(4):462-70
3494825
J Org Chem. 2002 May 3;67(9):3057-64
11975567
Appl Radiat Isot. 1999 Dec;51(6):643-50
10581679
Angew Chem Int Ed Engl. 2006 Sep 11;45(36):6047-50
16888726
Curr Med Chem. 2005;12(7):807-18
15853713
Bioorg Med Chem. 2008 Apr 15;16(8):4242-51
18343125
Bioconjug Chem. 2009 Mar 18;20(3):432-6
19226160
Bioconjug Chem. 2008 Dec;19(12):2462-70
19053298
J Org Chem. 2008 Feb 1;73(3):957-62
18166063
Eur J Nucl Med Mol Imaging. 2007 Nov;34(11):1823-1831
17492285
Appl Radiat Isot. 2007 Oct;65(10):1140-51
17574425
Int J Rad Appl Instrum A. 1986;37(12):1181-8
3028984
Bioconjug Chem. 2008 Jun;19(6):1202-10
18481886
Bioconjug Chem. 2008 Sep;19(9):1871-9
18754574
J Fluor Chem. 2008 Sep;129(9):799-805
19727427
Chembiochem. 2009 May 25;10(8):1321-4
19422010
Int J Rad Appl Instrum A. 1990;41(6):531-3
2163371
Appl Radiat Isot. 1994 Dec;45(12):1155-63
7894395
Curr Top Med Chem. 2007;7(18):1817-28
17979790
Biochemistry. 1989 May 30;28(11):4801-6
2669963
Synapse. 2007 Aug;61(8):637-45
17492764
Semin Nucl Med. 2007 Nov;37(6):400-19
17920348
J Fluor Chem. 1988 Jun;39(3):339-47
26523070
J Am Chem Soc. 2006 Dec 20;128(50):16394-7
17165796
Int J Radiat Oncol Biol Phys. 1992;22(1):199-212
1727119
Appl Radiat Isot. 2002 Sep;57(3):347-52
12201141
J Nucl Med. 1980 Aug;21(8):750-7
7400831
Nucl Med Biol. 2004 Feb;31(2):179-89
15013483
Nucl Med Biol. 1996 Apr;23(3):365-72
8782249
Ann Acad Med Singap. 2004 Mar;33(2):146-54
15098627
Nucl Med Biol. 2005 Jul;32(5):553-8
15982586
Curr Pharm Des. 2005;11(25):3221-35
16250851
Chemistry. 2009;15(15):3736-43
19267382
Chem Commun (Camb). 2007 Jun 21;(23):2330-2
17844736
Nucl Med Biol. 1999 May;26(4):473-9
10382853
Appl Radiat Isot. 2003 Oct;59(4):237-43
14522231
Int J Rad Appl Instrum A. 1992 Aug;43(8):989-96
1330984
Eur J Cancer. 2006 Aug;42(12):1720-7
16797972
Bioconjug Chem. 1994 Jul-Aug;5(4):352-6
7948102
Eur J Nucl Med. 2001 Jul;28(7):929-38
11504093
J Nucl Med. 2009 Jun;50(6):991-8
19443594
Bioconjug Chem. 2009 Apr;20(4):817-23
19323495
Nat Protoc. 2006;1(4):1655-61
17487148
Angew Chem Int Ed Engl. 2008;47(26):4922-5
18496798
Appl Radiat Isot. 1997 Feb;48(2):169-73
9219343
Int J Rad Appl Instrum A. 1986;37(8):685-93
3021669
J Nucl Med. 2008 Apr;49(4):573-86
18344441
Lancet Oncol. 2007 Sep;8(9):822-30
17765191
Radiat Res. 1987 Aug;111(2):292-304
3628717
Bioconjug Chem. 2003 Nov-Dec;14(6):1253-9
14624642
Int J Rad Appl Instrum A. 1986;37(8):649-61
3021666
Angew Chem Int Ed Engl. 2002 Jul 15;41(14):2596-9
12203546
Bioorg Med Chem. 2005 Nov 15;13(22):6195-205
16054371
Radiol Clin North Am. 2004 Nov;42(6):1033-53, viii
15488556
Nucl Med Biol. 2000 Feb;27(2):143-56
10773543
J Med Chem. 2007 Mar 8;50(5):1028-40
17328524
Neurodegener Dis. 2004;1(2-3):109-12
16908982
Nucl Med Biol. 1997 Nov;24(8):755-60
9428602
Nucl Med Biol. 2009 Feb;36(2):147-53
19217526
Bioconjug Chem. 2009 Feb;20(2):317-21
19132825
Chemistry. 2009;15(9):2140-7
19156812
Int J Rad Appl Instrum B. 1992 Apr;19(3):275-81
1629016
Semin Nucl Med. 2007 Nov;37(6):440-50
17920351
Bioconjug Chem. 2008 Aug;19(8):1684-8
18627198
Bioconjug Chem. 2005 Sep-Oct;16(5):1329-33
16173815
Int J Rad Appl Instrum A. 1990;41(6):583-6
2163375
Semin Nucl Med. 1985 Oct;15(4):377-94
3904006
Appl Radiat Isot. 2002 Sep;57(3):335-42
12201139
Int J Nucl Med Biol. 1984;11(2):141-2
6480255
J Nucl Med. 2006 Aug;47(8):1326-34
16883013
Nucl Med Biol. 1997 Apr;24(3):269-73
9228662
J Am Chem Soc. 2007 Jun 27;129(25):8018-25
17536798
Nucl Med Biol. 1994 Oct;21(7):1005-10
9234356
J Nucl Med. 1989 Mar;30(3):343-50
2738663
Appl Radiat Isot. 2001 Jun;54(6):927-33
11300406
Int J Radiat Oncol Biol Phys. 1996 Sep 1;36(2):417-28
8892467
Am Heart J. 1993 Mar;125(3):848-54
8438714
Int J Rad Appl Instrum A. 1986;37(12):1173-80
3028983
Nucl Med Biol. 2001 May;28(4):359-74
11395308
J Nucl Med. 1984 Nov;25(11):1212-21
6092569
Nucl Med Biol. 2003 Jan;30(1):1-9
12493537
Bioconjug Chem. 1994 Sep-Oct;5(5):491-2
7849082
Curr Opin Drug Discov Devel. 2008 Nov;11(6):803-19
18946845