Novel neuroprotective strategies in ischemic retinal lesions.
Retinal ischemia can be effectively modeled by permanent bilateral common carotid artery occlusion, which leads to chronic hypoperfusion-induced degeneration in the entire rat retina. The complex pathways leading to retinal cell death offer a complex approach of neuroprotective strategies. In the present review we summarize recent findings with different neuroprotective candidate molecules. We describe the protective effects of intravitreal treatment with: (i) urocortin 2; (ii) a mitochondrial ATP-sensitive K(+) channel opener, diazoxide; (iii) a neurotrophic factor, pituitary adenylate cyclase activating polypeptide; and (iv) a novel poly(ADP-ribose) polymerase inhibitor (HO3089). The retinoprotective effects are demonstrated with morphological description and effects on apoptotic pathways using molecular biological techniques.
Szabadfi
Krisztina
K
Department of Experimental Zoology and Neurobiology, University of Pecs, H-7624 Pecs, Hungary.
Mester
Laszlo
L
Department of Biochemistry and Medical Chemistry, University of Pecs, H-7624 Pecs, Hungary.
Reglodi
Dora
D
Department of Anatomy, University of Pecs, H-7624 Pecs, Hungary.
Kiss
Peter
P
Department of Anatomy, University of Pecs, H-7624 Pecs, Hungary.
Babai
Norbert
N
Department of Experimental Zoology and Neurobiology, University of Pecs, H-7624 Pecs, Hungary.
Racz
Boglarka
B
Department of Biochemistry and Medical Chemistry, University of Pecs, H-7624 Pecs, Hungary.
Kovacs
Krisztina
K
Department of Biochemistry and Medical Chemistry, University of Pecs, H-7624 Pecs, Hungary.
Szabo
Aliz
A
Department of Biochemistry and Medical Chemistry, University of Pecs, H-7624 Pecs, Hungary.
Tamas
Andrea
A
Department of Anatomy, University of Pecs, H-7624 Pecs, Hungary.
Gabriel
Robert
R
Department of Experimental Zoology and Neurobiology, University of Pecs, H-7624 Pecs, Hungary.
Atlasz
Tamas
T
Department of Experimental Zoology and Neurobiology, University of Pecs, H-7624 Pecs, Hungary.|Department of Sportbiology, University of Pecs, H-7624 Pecs, Hungary.
D000818:Animals; D001562:Benzimidazoles / Q000627:therapeutic use; D003981:Diazoxide / Q000627:therapeutic use; D004195:Disease Models, Animal; D007511:Ischemia / Q000188:drug therapy / Q000473:pathology; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide / Q000627:therapeutic use; D015356:Retinal Artery Occlusion / Q000188:drug therapy* / Q000473:pathology; D054832:Urocortins / Q000627:therapeutic use
D001562:Benzimidazoles; C508983:HO 3089; D018696:Neuroprotective Agents; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D054832:Urocortins; D003981:Diazoxide
Invest Ophthalmol Vis Sci. 2008 Nov;49(11):4971-81
18566458
Exp Eye Res. 2006 Mar;82(3):488-95
16168987
Dev Neurosci. 2002;24(1):14-23
12145407
Acta Ophthalmol. 2009 Jun;87(4):362-7
19416114
Eur J Ophthalmol. 2003 Jan-Feb;13(1):80-5
12635679
Prog Neurobiol. 2008 Feb;84(2):148-56
18078706
Graefes Arch Clin Exp Ophthalmol. 2004 Mar;242(3):240-4
14770318
Ann N Y Acad Sci. 1999 Jun 30;874:27-37
10415518
FEBS Lett. 2005 Aug 15;579(20):4259-64
16054139
Gen Comp Endocrinol. 2007 Aug-Sep;153(1-3):108-14
17289046
Invest Ophthalmol Vis Sci. 2002 Feb;43(2):528-36
11818401
Neuropharmacology. 2003 Oct;45(5):623-36
12941376
Naunyn Schmiedebergs Arch Pharmacol. 2000 Jul;362(1):74-81
10935536
J Neurochem. 2003 Nov;87(4):969-80
14622127
Graefes Arch Clin Exp Ophthalmol. 2006 Feb;244(2):199-204
15983810
Invest Ophthalmol Vis Sci. 1998 Apr;39(5):777-85
9538885
Brain Res Dev Brain Res. 1990 Feb 1;51(2):185-94
2323027
Neurosci Lett. 2009 May 8;455(1):42-5
19429103
Brain Res. 2001 Jan 26;890(1):118-29
11164774
J Mol Neurosci. 2008 Nov;36(1-3):16-25
18483879
Invest Ophthalmol Vis Sci. 2006 May;47(5):2114-24
16639023
J Cereb Blood Flow Metab. 2006 May;26(5):684-95
16177811
Vis Neurosci. 1991 Apr;6(4):383-91
2059572
Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1299-304
12601062
Ann N Y Acad Sci. 2009 Apr;1163:348-52
19456357
Endocrinology. 2004 Jan;145(1):24-35; discussion 21-3
12970163
Compr Ophthalmol Update. 2007 Jan-Feb;8(1):17-28
17394756
Prog Retin Eye Res. 2008 May;27(3):284-330
18448380
Vision Res. 1993 Mar;33(4):429-36
8099245
Trends Pharmacol Sci. 2004 May;25(5):259-64
15120492
Brain Res Bull. 1984 May;12(5):539-42
6380651
Neuropharmacology. 2000 Jun 8;39(8):1368-76
10818253
Prog Brain Res. 2008;173:583-90
18929136
Exp Eye Res. 2009 Mar;88(3):361-6
19101544
J Biol Chem. 2002 May 3;277(18):16075-80
11847214
Brain Res Rev. 2007 Apr;54(1):162-80
17296232
Eur J Pharmacol. 1994 Dec 27;271(2-3):489-95
7705449
Stroke. 1999 Dec;30(12):2713-8; discussion 2718-9
10583002
Brain Res. 1999 Aug 21;839(1):66-73
10482800
Ann N Y Acad Sci. 2006 Jul;1070:531-4
16888220
Ophthalmologe. 2010 Apr;107(4):347-53
19787355
Biochem Pharmacol. 2003 Apr 15;65(8):1373-82
12694878
Ann N Y Acad Sci. 2006 Jul;1070:507-11
16891269
Mol Endocrinol. 2005 Feb;19(2):441-58
15514029
Invest Ophthalmol Vis Sci. 2009 Feb;50(2):836-43
18936152
Science. 2002 Jul 12;297(5579):259-63
12114629
Invest Ophthalmol Vis Sci. 1994 Mar;35(3):907-15
8125754
Free Radic Biol Med. 2008 Apr 1;44(7):1286-94
18082149
Curr Pharm Des. 2004;10(23):2861-89
15379674
Prog Retin Eye Res. 2008 Nov;27(6):622-47
18940262
Brain Res. 2005 Jul 27;1051(1-2):72-80
16004973
Exp Eye Res. 2009 May;88(5):974-82
19166832
Toxicol Lett. 2003 Apr 4;139(2-3):153-62
12628750
Ann Thorac Surg. 2001 Dec;72(6):1849-54
11789759
Neuroscience. 2008 Aug 26;155(3):937-47
18640247
J Neurosci. 2002 Jan 15;22(2):404-12
11784785
Neurotox Res. 2009 Jul;16(1):68-76
19526300
Brain Res. 2004 Sep 3;1019(1-2):97-104
15306243
Neurotox Res. 2007 Sep;12(2):105-11
17967734
J Neurochem. 2009 Oct;111(2):488-98
19682205
J Neurochem. 2006 Sep;98(6):1732-45
16903875
Prog Retin Eye Res. 2004 Jan;23(1):91-147
14766318
Am J Ophthalmol. 1984 Feb;97(2):168-72
6421164
Am J Physiol Heart Circ Physiol. 2002 Sep;283(3):H1005-11
12181130
Neurosci Lett. 2004 Nov 30;372(1-2):110-3
15531098
Regul Pept. 2002 Nov 15;109(1-3):71-4
12409217
Neurosci Lett. 2005 Oct 28;387(3):168-72
16026930
Graefes Arch Clin Exp Ophthalmol. 2006 May;244(5):627-33
16205934
Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1237-44
12601054
Brain Res. 2005 Oct 26;1060(1-2):73-80
16202986
Pharmacol Rev. 2009 Sep;61(3):283-357
19805477
Biochem Biophys Res Commun. 2005 Oct 28;336(3):731-6
16061206
Neurotox Res. 2005 Nov;8(3-4):227-33
16371317
Brain Res Bull. 2010 Mar 16;81(4-5):497-504
19751807
Cell Death Differ. 2001 Aug;8(8):801-7
11526433
Exp Eye Res. 2006 May;82(5):767-79
16359664
Brain Res Bull. 2005 Jul 30;66(2):85-90
15982523
Pharmacol Rev. 2002 Sep;54(3):375-429
12223530
Anesthesiology. 2009 Apr;110(4):774-80
19322943
Retina. 2008 Mar;28(3):511-7
18327147
Am J Pathol. 2003 Nov;163(5):1997-2008
14578199
Brain Res Dev Brain Res. 1990 May 1;53(2):194-9
2357792
Am J Pathol. 2007 Jul;171(1):53-67
17591953
Ann N Y Acad Sci. 2006 Jul;1070:149-55
16888157
Brain Res. 2006 May 4;1087(1):168-74
16624259
Neurosci Lett. 2005 Jan 20;373(3):195-9
15619542
Stroke. 2002 Apr;33(4):1107-12
11935068
Tohoku J Exp Med. 1999 Mar;187(3):227-36
10458479
Vision Res. 1999 Dec;39(24):3995-4002
10748932
Brain Res. 2004 Jul 23;1015(1-2):154-60
15223379
Neurobiol Dis. 2009 Jun;34(3):535-44
19344761
Brain Res Brain Res Rev. 2004 Nov;46(3):282-94
15571770
J Neuropathol Exp Neurol. 2003 Apr;62(4):329-39
12722825
J Endocrinol. 2007 Apr;193(1):157-69
17400813
Regul Pept. 2000 Sep 25;93(1-3):85-92
11033056
J Neurosci. 2007 Sep 19;27(38):10311-9
17881537
BMC Neurosci. 2009 May 27;10:52
19473529
Neurosci Lett. 1992 Sep 14;144(1-2):124-6
1436691
Exp Eye Res. 2008 Feb;86(2):366-74
18160067
Front Neuroendocrinol. 2007 Apr;28(1):1-27
17083971
Retina. 2009 Feb;29(2):262-8
18854781
Surv Ophthalmol. 1999 Jun;43 Suppl 1:S102-28
10416754
Exp Eye Res. 2003 Apr;76(4):505-16
12634114
Cardiovasc Res. 2003 Jul 1;59(1):1-6
12829170
Neurotox Res. 2000;2(2-3):215-27
16787842
J Comp Neurol. 1989 Feb 15;280(3):424-35
2783937
Invest Ophthalmol Vis Sci. 2010 Apr;51(4):2197-207
19875663
Brain Res. 2004 May 22;1008(2):252-60
15145763
Prog Retin Eye Res. 2009 Jan;28(1):63-86
19070679
J Mol Neurosci. 2008 Nov;36(1-3):57-60
18642101
Doc Ophthalmol. 2003 Jan;106(1):51-9
12675486
Neurosci Lett. 1997 Dec 5;238(3):127-30
9464636
Brain Res. 2008 Jan 10;1188:35-43
18053973
Vis Neurosci. 1991 Mar;6(3):257-69
2054327
Ann N Y Acad Sci. 2000;921:366-9
11193854
J Biol Chem. 2006 Mar 31;281(13):8788-95
16446354
Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10659-64
12130665
Neurotox Res. 2007 Sep;12(2):95-104
17967733
Doc Ophthalmol. 2009 Feb;118(1):55-61
18483822
Histol Histopathol. 2003 Oct;18(4):1219-42
12973690
J Cereb Blood Flow Metab. 2002 Apr;22(4):431-43
11919514
J Neurosci Res. 2003 Jul 15;73(2):206-14
12836163
Curr Eye Res. 2001 Apr;22(4):245-52
11462162
Biol Pharm Bull. 2007 Oct;30(10):1895-7
17917258
Stroke. 2003 Jul;34(7):1796-802
12791941
Can J Physiol Pharmacol. 2005 Jun;83(6):459-65
16049545
Brain Res Bull. 2004 Feb 15;62(6):461-6
15036558
Mol Pharmacol. 2001 Jun;59(6):1497-505
11353811
Int J Biochem Cell Biol. 2002 Aug;34(8):907-10
12007627
J Neurosci Res. 2004 Jun 1;76(5):697-704
15139028
J Pharmacol Exp Ther. 2001 Jan;296(1):216-23
11123383
Regul Pept. 2006 Nov 15;137(1-2):20-6
16945433
Invest Ophthalmol Vis Sci. 2003 Jun;44(6):2750-6
12766083
Brain Res Dev Brain Res. 2005 May 12;156(2):193-201
16099306
Br J Ophthalmol. 1984 Jan;68(1):47-57
6689935
Am J Pathol. 2008 Jul;173(1):2-13
18535182