title: Assessement by laser Doppler of the peripheral tumour perfusion after radiofrequency ablation for colorectal liver mestasis--experimental study.
abstract: Colorectal cancer became one of the most frequent malignant conditions of the past two decades. Non-resecable liver metastases might be destroyed in situ by radiofrequency although the local recurrence is still very important. Laser-Doppler flowmetry has proved to be a simple technique for monitoring the microcirculation, hereby the tissue perfusion at the edge of the post radiofrequency necrosis. The aim of the study was to evaluate microcirculation using lasser-Doppler for hepatic tissue and peripheral tumour perfusion after radiofrequency and the influence of local temperature increasing at 42 degrees C on tissular perfusion. Colorectal adenocarcinoma (CC531s) was used for liver tumour inoculationin on 15 Wag/Rij rats. Twenty-one days after inoculation, perfusion in hepatic tissue, on the tumour before and after radiofrequency treatment was mesured. When hepatic tissue was heated at 42 degrees C there was an increase in tissular perfusion, on the other part, heating the tumoural tissue do not increase perfusion. After radiofrequency in the periphery of necrosis the perfusion was still present, despite a clear drop towards initial level. Assessing the local microcirculation and tissue temperature during RF ablation by Laser-Doppler might be useful not only for RF efficiency evaluation but also as an indication for associating adjuvant local chemotherapy.
authors.affiliation: Department of Surgery no 1, University of Medicine and Pharmacy "Iuliu Haţieganu", Cluj-Napoca, Romania.
authors.forename: C G
authors.initials: CG
authors.lastname: Precup
authors.forename: D
authors.initials: D
authors.lastname: Gonganau-Nitu
authors.forename: R R
authors.initials: RR
authors.lastname: Scurtu
authors.forename: G
authors.initials: G
authors.lastname: Dindelegan
authors.forename: A
authors.initials: A
authors.lastname: Biro
authors.forename: O
authors.initials: O
authors.lastname: Soritau
authors.forename: C
authors.initials: C
authors.lastname: Crişan
authors.forename: O
authors.initials: O
authors.lastname: Serban
authors.forename: G
authors.initials: G
authors.lastname: Pufu
authors.forename: C
authors.initials: C
authors.lastname: Ciuce
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply* / Q000556:secondary / Q000601:surgery; D000818:Animals; D017115:Catheter Ablation; D015179:Colorectal Neoplasms / Q000098:blood supply* / Q000473:pathology / Q000601:surgery; D004195:Disease Models, Animal; D006498:Hepatectomy / Q000379:methods; D017078:Laser-Doppler Flowmetry; D008113:Liver Neoplasms / Q000098:blood supply* / Q000556:secondary / Q000601:surgery; D008297:Male; D008833:Microcirculation / Q000528:radiation effects; D009365:Neoplasm Regression, Spontaneous; D009367:Neoplasm Staging; D051381:Rats; D017208:Rats, Wistar; D018570:Risk Assessment; D012680:Sensitivity and Specificity