title: Delta-sarcoglycan gene polymorphism frequency in Amerindian and Mestizo populations of Mexico.
abstract: Mutations on the delta-sarcoglycan gene have been associated with the development of both hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy. Recently, the polymorphism c.-94C>G was associated with HCM in Japanese patients. The aim of our study was to evaluate the frequency of c.-94C>G polymorphism in Mexican-Amerindian and Mexican-Mestizo populations. We analyzed the frequency of this polymorphism in 165 Mexican-Amerindian individuals (23 Triquis, 25 Zapotecos, 24 Mayas, 41 Nahuas, and 52 Mixtecos) and 100 unrelated Mexican-Mestizos. Allele frequencies were similar in all Amerindian groups (0.33 Triquis, 0.54 Zapotecos, 0.54 Mayas, 0.46 Nahuas, and 0.49 Mixtecos). When compared with Mexican-Mestizos, only Triquis were different (p = 0.00742). However, when comparing the total sample of the Amerindian population with the Mestizos, the difference was not significant (p = 0.12225). Allele frequencies of Mexican populations were higher than in Asians and less than African and European populations (p < 0.05). These data show that the distribution of the C allele is higher in Mexican populations studied and consequently it is necessary to define if this may be associated with genetic susceptibility for HCM in the Mexican patients.
authors.affiliation: Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico. romaorr@yahoo.com.mx
authors.forename: Rosa María
authors.initials: RM
authors.lastname: Ordoñez-Razo
authors.forename: Samuel
authors.initials: S
authors.lastname: Canizales-Quinteros
authors.forename: Maricela
authors.initials: M
authors.lastname: Rodríguez-Cruz
authors.forename: Rosenda
authors.initials: R
authors.lastname: Peñaloza
authors.forename: Fernando
authors.initials: F
authors.lastname: Minauro-Sanmiguel
authors.forename: Thelma
authors.initials: T
authors.lastname: Canto-Cetina
authors.forename: Patricia
authors.initials: P
authors.lastname: Canto
authors.forename: Ramón
authors.initials: R
authors.lastname: Coral-Vázquez
authors.forename: Fabio
authors.initials: F
authors.lastname: Salamanca-Gómez
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D002311:Cardiomyopathy, Dilated / Q000235:genetics; D024741:Cardiomyopathy, Hypertrophic, Familial / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008800:Mexico; D008875:Middle Aged; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D049031:Sarcoglycans / Q000235:genetics*
chemical_list: D049031:Sarcoglycans