title: Effect of early cerebral magnetic resonance imaging on clinical decisions in infective endocarditis: a prospective study.
abstract: BACKGROUND
  Neurologic complications of endocarditis can influence diagnosis, therapeutic plans, and prognosis.
  
  
  OBJECTIVE
  To describe how early cerebral magnetic resonance imaging (MRI) affects the diagnosis and management of endocarditis in hospitalized adults.
  
  
  METHODS
  Single-center prospective study between June 2005 and October 2008. (ClinicalTrials.gov registration number: NCT00144885)
  
  
  METHODS
  Tertiary care university hospital in France.
  
  
  METHODS
  130 patients with endocarditis.
  
  
  METHODS
  Cerebral MRI with angiography performed up to 7 days after admission and before any surgical intervention.
  
  
  METHODS
  2 experts jointly established the endocarditis diagnostic classification (according to Duke-modified criteria) and therapeutic plans just before and after MRI and then compared them.
  
  
  RESULTS
  Endocarditis was initially classified as definite in 77 patients and possible in 50 and was excluded in 3. Sixteen patients (12%) had acute neurologic symptoms. Cerebral lesions were detected by MRI in 106 patients (82% [95% CI, 75% to 89%]), including ischemic lesions in 68, microhemorrhages in 74, and silent aneurysms in 10. Solely on the basis of MRI results and excluding microhemorrhages, diagnostic classification of 17 of 53 (32%) cases of nondefinite endocarditis was upgraded to either definite (14 patients) or possible (3 patients). Endocarditis therapeutic plans were modified for 24 (18%) of the 130 patients, including surgical plan modifications for 18 (14%). Overall, early MRI led to modifications of diagnosis or therapeutic plan in 36 patients (28% [CI, 20% to 36%]).
  
  
  CONCLUSIONS
  Investigators did not assess whether the MRI-related changes in diagnosis and therapeutic plans improved patient outcomes or led to unnecessary procedures and increased costs.
  
  
  CONCLUSIONS
  Cerebral lesions were identified by MRI in many patients with endocarditis but no neurologic symptoms. The MRI findings affected both diagnostic classifications and clinical management plans.
  
  
  BACKGROUND
  French Ministry of Health.
authors.affiliation: Paris 7 University Medical School, AP-HP Bichat University Hospital, and INSERM CIC 007, Paris, France. xavier.duval@bch.aphp.fr
authors.forename: Xavier
authors.initials: X
authors.lastname: Duval
authors.forename: Bernard
authors.initials: B
authors.lastname: Iung
authors.forename: Isabelle
authors.initials: I
authors.lastname: Klein
authors.forename: Eric
authors.initials: E
authors.lastname: Brochet
authors.forename: Gabriel
authors.initials: G
authors.lastname: Thabut
authors.forename: Florence
authors.initials: F
authors.lastname: Arnoult
authors.forename: Laurent
authors.initials: L
authors.lastname: Lepage
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Laissy
authors.forename: Michel
authors.initials: M
authors.lastname: Wolff
authors.forename: Catherine
authors.initials: C
authors.lastname: Leport
mesh_terms: D000368:Aged; D000792:Angiography; D001921:Brain / Q000473:pathology*; D002561:Cerebrovascular Disorders / Q000209:etiology / Q000473:pathology*; D004696:Endocarditis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome