[Analysis of therapeutic effects of rural patients with hypertension by combination administration of low dosage of hydrochlorothiazide and nitrendipine].
OBJECTIVE
To evaluate the therapeutic effects of combination administration of hydrochlorothiazide and nitrendipine at low dosage in the treatment of rural hypertension patients.


METHODS
By the method of cluster random sampling, 5292 primary hypertension patients from Fuxin, Liaoning Province were divided into health education group (control group) and drug intervention group in June 2006. The drug intervention group were treated with hydrochlorothiazide, nitrendipine and captopril by stepwise approach and we observe the antihypertensive effect of drug and the effect on the onset of stroke.


RESULTS
The average follow-up time was 15 months. At last, 308 patients were lost to follow-up (the lost follow-up rate was 5.8 percent). The 4984 in cohort, including 2530 of intervention group and 2454 of control group, had examination of all indicators. Through health education and drug intervention, the average blood pressure in drug intervention group decreased by 16.1/9.4 mm Hg (1 mm Hg = 0.133 kPa) while the average blood pressure in control group decreased by 6.7/3.5 mm Hg. The control rate of blood pressure in drug intervention group was higher than control group (33.1% vs. 15.1%, P < 0.001). Through drug intervention, the morbidity risk of nonfatal stroke in drug intervention group decreased by 57.3% compared to control group, the total morbidity risk of stroke decreased by 59.4%. The results had significant statistical difference. And, the morbidity of severe hypopotassaemia (K(+) < 3.0 mmol/L) and diabetes mellitus had no significant statistical difference between two groups.


CONCLUSIONS
The low-cost antihypertensive program based on thiazide had good antihypertensive effect, high safety and good cost-effect ratio. The program could be used in rural areas of China.
Sun
Zhao-Qing
ZQ
Department of Cardiology, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Zheng
Li-Qiang
LQ
Zhang
Da-Yi
DY
Zhang
Xin-Zhong
XZ
Zhang
Xin-Gang
XG
Liu
Shuang-Shuang
SS
Xu
Chang-Lu
CL
Li
Jue
J
Hu
Da-Yi
DY
Sun
Ying-Xian
YX
D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D002681:China; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009568:Nitrendipine / Q000627:therapeutic use*; D010353:Patient Education as Topic; D012424:Rural Population
D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; D009568:Nitrendipine