[A drug with the broad spectrum of pharmacological activity for the treatment of complex neuropsychic disorders].
The influence of a pyrrolo-pyrazine derivative AL-613 (synthesized at the Zakusov Institute of Pharmacology) on the behavior of outbred male albino rats has been studied on various experimental models. It was established that AL-613 produces anxiolytic action in a conflict situation model and antidepressant action in forced swim paradigm test, improves active avoidance conditioned reflex acquisition, and increases the amplitude of transcallosal evoked potential. The substance demonstrated properties of anxiolytics, antidepressants, and nootropes. These effects were not accompanied by side effects, which are characteristic of many other drugs of these classes. The preparation exhibit low acute toxicity. It is concluded that AL-613 can be considered as a complex "optimizer" of damaged central nervous system functions.
Molodavkin
G M
GM
Aldarmaa
Jalsrai
J
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000633:toxicity; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology* / Q000633:toxicity; D011719:Pyrazines / Q000494:pharmacology* / Q000633:toxicity; D011758:Pyrroles / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D023382:Toxicity Tests, Acute
C549192:1,2,3,4-tetrahydropyrrolo(1,2-a)pyrazine; D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D018697:Nootropic Agents; D011719:Pyrazines; D011758:Pyrroles