title: Vitamin d deficiency and tuberculosis progression.
abstract: To assess the association between vitamin D deficiency and tuberculosis disease progression, we studied vitamin D levels in a cohort of tuberculosis patients and their contacts (N = 129) in Pakistan. Most (79%) persons showed deficiency. Low vitamin D levels were associated with a 5-fold increased risk for progression to tuberculosis.
authors.affiliation: Aga Khan University, Karachi, Pakistan.
authors.forename: Najeeha
authors.initials: N
authors.lastname: Talat
authors.forename: Sharon
authors.initials: S
authors.lastname: Perry
authors.forename: Julie
authors.initials: J
authors.lastname: Parsonnet
authors.forename: Ghaffa
authors.initials: G
authors.lastname: Dawood
authors.forename: Rabia
authors.initials: R
authors.lastname: Hussain
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis; D012307:Risk Factors; D012737:Sex Factors; D012959:Socioeconomic Factors; D014397:Tuberculosis, Pulmonary / Q000150:complications* / Q000382:microbiology / Q000473:pathology*; D014808:Vitamin D Deficiency / Q000209:etiology*
references.citation: Infect Immun. 1987 Dec;55(12):2945-50
references.pmid: 3119492
references.citation: Trends Microbiol. 2008 Jul;16(7):336-44
references.pmid: 18513971
references.citation: Int J Epidemiol. 2008 Feb;37(1):113-9
references.pmid: 18245055
references.citation: J Coll Physicians Surg Pak. 2009 May;19(5):267-8
references.pmid: 19409155
references.citation: Clin Vaccine Immunol. 2007 Dec;14(12):1578-86
references.pmid: 17928427
references.citation: N Engl J Med. 2007 Jul 19;357(3):266-81
references.pmid: 17634462
references.citation: Thorax. 1985 Mar;40(3):187-90
references.pmid: 3872485
references.citation: Clin Infect Dis. 2008 Feb 1;46(3):443-6
references.pmid: 18173355
references.citation: Science. 2006 Mar 24;311(5768):1770-3
references.pmid: 16497887
references.citation: J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):793-8
references.pmid: 17223549
references.citation: J Pak Med Assoc. 2008 Sep;58(9):482-4
references.pmid: 18846794
references.citation: J Immunol. 2007 Jun 1;178(11):7190-8
references.pmid: 17513768
references.citation: Am J Respir Crit Care Med. 2009 May 1;179(9):843-50
references.pmid: 19179490
references.citation: Am Rev Respir Dis. 1988 Oct;138(4):768-70
references.pmid: 2849343