Fetal anatomy of peripheral lymphatic vessels: a D2-40 immunohistochemical study using an 18-week human fetus (CRL 155 mm).
We demonstrated fetal peripheral lymphatic vessels (LVs) using D2-40 immunohistochemistry in a whole female fetus (18 weeks of gestation, CRL 155 mm) except for the head. There were abundant LVs in the thyroid gland, lung, stomach, small intestine, rectum and pancreas, whereas no LVs were seen in the parathyroid gland, spleen and adrenal cortex. In the liver, except for the gallbladder bed, LVs were still restricted to around hilar thick portal veins and around the hepatic vein terminals. Subcutaneous LVs were well developed throughout the body even in areas where no or few perforating LVs connected with the deep LVs. The diaphragm contained abundant, dilated LVs in the pleural half of its thickness. LVs were also seen not only along supplying arteries of muscles and cartilage but also along the epimysium and perichondrium. LVs ran in a space between the obliquus internus and transversus abdominis but not between the obliquus internus and obliquus externus. Some tight connective tissues such as the sacrotuberous ligament contained abundant LVs. The intervertebral foramen contained a lymphatic plexus. The present observations provide a better understanding of peripheral lymphatic development. The fetal lymphatic morphology seems not to represent a mini-version of the adult morphology.
Jin
Zhe Wu
ZW
Department of Surgery and Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonju, Korea.
Nakamura
Takuo
T
Yu
Hee Chul
HC
Kimura
Wataru
W
Murakami
Gen
G
Cho
Baik Hwan
BH
D005260:Female; D005333:Fetus / Q000033:anatomy & histology* / Q000166:cytology / Q000196:embryology; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D042601:Lymphatic Vessels / Q000033:anatomy & histology* / Q000166:cytology / Q000196:embryology*
Histopathology. 2006 Sep;49(3):265-73
16918973
Lymphology. 1990 Mar;23(1):36-8
2352442
Plast Reconstr Surg. 2007 Sep 15;120(4):982-991
17805128
Surg Radiol Anat. 1991;13(2):89-104
1925922
Acta Anat (Basel). 1974;89(1):149-60
4846336
Anat Rec (Hoboken). 2008 Jun;291(6):643-52
18484610
Nat Immunol. 2004 Jan;5(1):74-80
14634646
Biol Reprod. 2004 Dec;71(6):2029-36
15317687
Arch Histol Cytol. 2008 May;71(1):1-22
18622090
Br J Surg. 1971 Dec;58(12):925-30
5130202
Surg Radiol Anat. 1988;10(2):121-35
3135617
J Thorac Cardiovasc Surg. 2009 Jun;137(6):1406-14
19464457
Anat Anz. 1970;127(2):189-99
4097040
Microsc Res Tech. 1997 Jun 1-15;37(5-6):456-77
9220424
Am J Anat. 1975 Jan;142(1):15-27
1167215
Clin Anat. 2009 Sep;22(6):716-29
19644969
Lymphat Res Biol. 2003;1(1):33-40
15624319
Arch Histol Cytol. 1992 Dec;55(5):525-38
1295550
Acta Morphol Neerl Scand. 1980 Dec;18(4):323-35
7211499
Lymphat Res Biol. 2008;6(2):89-95
18564924