A novel approach to indoloditerpenes by Nazarov photocyclization: synthesis and biological investigations of terpendole E analogues.
The application of the Nazarov photocyclization as a mild and efficient method for access to the basic core of novel indoloditerpenoid derivatives is reported. The detailed synthesis of these new analogues of terpendole E, as well as their evaluation as potential inhibitors of KSP, is described.
Churruca
Fátima
F
Department of Chemistry and Mineralogy, Institute of Organic Chemistry, University of Leipzig, Johannisallee 29, 04103 Leipzig, Germany.
Fousteris
Manolis
M
Ishikawa
Yuichi
Y
Rekowski
Margarete von Wantoch
Mv
Hounsou
Candide
C
Surrey
Thomas
T
Giannis
Athanassios
A
D003500:Cyclization; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D010777:Photochemistry
D004224:Diterpenes; D007211:Indoles; C477863:terpendole E