title: [The effects of occupational soluble chromate exposure on immunological function of T-cell].
abstract: OBJECTIVE
  To investigate the early changes of some immunological function of T-cell in chromate workers.
  
  
  METHODS
  A total of 115 workers exposed to different levels of soluble chromate were enrolled in exposed group; while 90 non-exposure workers who lived far away from the chromate plant were enrolled as control. The air concentration of soluble chromate was determined by atomic absorption spectrometry. CD3(+), CD3(+)CD4(+), CD3(+)CD8(+) and CD4(+)/CD8(+) of T-cell were determined by flow cytometry analysis.
  
  
  RESULTS
  The individual air chromate concentration in the exposed group was (27.51 +/- 33.25) microg/m(3), and the control group was (0.16 +/- 0.15) microg/m(3). The significant difference between the two groups was observed (z = 8.045, P < 0.01). The levels of the lymphocyte subsets (CD3(+), CD3(+)CD4(+), CD3(+)CD8(+) and CD4(+)/CD8(+)) in exposed group were (30.08 +/- 17.75)%, (1.04 +/- 1.73)%, (11.94 +/- 9.78)%, 0.10 +/- 0.14. While, those of control group were (63.00 +/- 13.57)%, (30.51 +/- 5.16)%, (14.82 +/- 4.59)%, 2.17 +/- 0.53, higher than that of the exposed group (z values were 4.484, 5.227, 1.976, -5.218, respectively, P < 0.05).
  
  
  CONCLUSIONS
  On the basis of individual air monitoring, the cellular immune function affected by soluble chromate is mainly based on T lymphocyte inhibition. The indicators CD3(+)CD4(+) mentioned above may be considered as efficient biomarkers in further research.
authors.affiliation: Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing 100191, China.
authors.forename: Lei
authors.initials: L
authors.lastname: Yan
authors.forename: Tian-Cheng
authors.initials: TC
authors.lastname: Wang
authors.forename: Ping-Ping
authors.initials: PP
authors.lastname: He
authors.forename: Yan-Hui
authors.initials: YH
authors.lastname: Ma
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
authors.forename: Lan-Zheng
authors.initials: LZ
authors.lastname: Liu
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Jing-Wen
authors.initials: JW
authors.lastname: Zhou
authors.forename: Xian-Mei
authors.initials: XM
authors.lastname: DU
authors.forename: Jia-Jie
authors.initials: JJ
authors.lastname: Zang
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Guang
authors.initials: G
authors.lastname: Jia
mesh_terms: D000328:Adult; D016516:CD4-CD8 Ratio; D016022:Case-Control Studies; D002840:Chromates / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D037182:T-Cell Antigen Receptor Specificity / Q000187:drug effects / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology*
chemical_list: D002840:Chromates