title: Towards click bioconjugations on cube-octameric silsesquioxane scaffolds.
abstract: Cube-octameric silsesquioxane (POSS) based conjugation scaffolds for copper catalysed azide-alkyne [3+2] cycloaddition are reported. The synthetic route to octaazido and octaalkyno functionalised POSS templates without cage rearrangements is described. A set of click couplings is conducted including the first effective conjugation with a fully unprotected functional peptide towards a POSS assembled peptide octamer.
authors.affiliation: Clemens Schöpf Institute of Organic Chemistry and Biochemistry, Technische Universität Darmstadt, Petersenstr. 22, 64287, Darmstadt, Germany.
authors.forename: Sebastian
authors.initials: S
authors.lastname: Fabritz
authors.forename: Dirk
authors.initials: D
authors.lastname: Heyl
authors.forename: Viktor
authors.initials: V
authors.lastname: Bagutski
authors.forename: Martin
authors.initials: M
authors.lastname: Empting
authors.forename: Eckhard
authors.initials: E
authors.lastname: Rikowski
authors.forename: Holm
authors.initials: H
authors.lastname: Frauendorf
authors.forename: Ildiko
authors.initials: I
authors.lastname: Balog
authors.forename: Wolf-Dieter
authors.initials: WD
authors.lastname: Fessner
authors.forename: Jörg J
authors.initials: JJ
authors.lastname: Schneider
authors.forename: Olga
authors.initials: O
authors.lastname: Avrutina
authors.forename: Harald
authors.initials: H
authors.lastname: Kolmar
mesh_terms: D000480:Alkynes / Q000737:chemistry; D001386:Azides / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D017646:Organosilicon Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D001386:Azides; D017646:Organosilicon Compounds; D003300:Copper