title: Lung transplantation in patients with cystic fibrosis and Mycobacterium abscessus infection.
abstract: Mycobacterium abscessus lung disease is difficult to treat and has been considered a strong relative contraindication to lung transplantation. We performed double lung transplantation in three cystic fibrosis patients with ongoing, and a fourth with recent treatment for Mycobacterium abscessus lung infection. Despite prolonged antibiotic courses and adjustment of immunosuppressive therapy the first three patients developed skin infection and abscesses. At follow-up after 1, 3, 5 and 7years respectively no patient had evidence of M abscessus infection and all had stable lung function. Lung transplantation in patients with M abscessus lung infection is feasible but may involve severe complications.
authors.affiliation: Department of Respiratory Medicine and Allergology, Bruna Stråket 11b, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden. marita.gilljam@lungall.gu.se
authors.forename: Marita
authors.initials: M
authors.lastname: Gilljam
authors.forename: Henrik
authors.initials: H
authors.lastname: Scherstén
authors.forename: Martin
authors.initials: M
authors.lastname: Silverborn
authors.forename: Bodil
authors.initials: B
authors.lastname: Jönsson
authors.forename: Annika
authors.initials: A
authors.lastname: Ericsson Hollsing
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D003550:Cystic Fibrosis / Q000382:microbiology* / Q000601:surgery*; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D009164:Mycobacterium Infections / Q000150:complications* / Q000188:drug therapy; D020127:Recovery of Function; D019172:Transplantation Conditioning; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents