title: Do we already know how spectrin attracts ankyrin?
abstract: The interaction of ankyrin and spectrin yields the major anchor between the membrane skeleton and the lipid bilayer. It is critical for red cell deformability and stability, and it is also involved in the cellular localization of several proteins, in cell differentiation, and in neuron activity. Therefore, its nature is of great interest, and recently, several researchers have had varying degrees of success in elucidating the structural basis of ankyrin-spectrin recognition. In this short paper, we briefly summarize the data obtained and compare the resulting conclusions.
authors.affiliation: Research and Development Centre Novasome Sp. z o.o., 51-423 Wrocław, Poland. aleksander.czogalla@cbr.novasome.pl
authors.forename: Aleksander
authors.initials: A
authors.lastname: Czogalla
authors.forename: Aleksander F
authors.initials: AF
authors.lastname: Sikorski
mesh_terms: D017487:Ankyrins / Q000097:blood / Q000378:metabolism*; D004907:Erythrocyte Deformability; D004912:Erythrocytes / Q000502:physiology; D051272:Glucose Transporter Type 1 / Q000097:blood / Q000378:metabolism; D006021:Glycophorins / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000097:blood / Q000378:metabolism; D007700:Kinetics; D008051:Lipid Bilayers / Q000378:metabolism; D008954:Models, Biological; D013049:Spectrin / Q000378:metabolism*
chemical_list: D017487:Ankyrins; D051272:Glucose Transporter Type 1; D006021:Glycophorins; D047908:Intracellular Signaling Peptides and Proteins; D008051:Lipid Bilayers; C486467:UNC5CL protein, human; D013049:Spectrin
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