Model-based correction of the influence of body position on continuous segmental and hand-to-foot bioimpedance measurements.
Bioimpedance spectroscopy (BIS) is suitable for continuous monitoring of body water content. The combination of body posture and time is a well-known source of error, which limits the accuracy and therapeutic validity of BIS measurements. This study evaluates a model-based correction as a possible solution. For this purpose, an 11-cylinder model representing body impedance distribution is used. Each cylinder contains a nonlinear two-pool model to describe fluid redistribution due to changing body position and its influence on segmental and hand-to-foot (HF) bioimpedance measurements. A model-based correction of segmental (thigh) and HF measurements (Xitron Hydra 4200) in nine healthy human subjects (following a sequence of 7 min supine, 20 min standing, 40 min supine) has been evaluated. The model-based compensation algorithm represents a compromise between accuracy and simplicity, and reduces the influence of changes in body position on the measured extracellular resistance and extracellular fluid by up to 75 and 70%, respectively.
Medrano
Guillermo
G
Philips Chair for Medical Information Technology (MedIT), Helmholtz-Institute for Biomedical Engineering, RWTH Aachen University, Pauwelsstrasse 20, 52074, Aachen, Germany. medrano@hia.rwth-aachen.de
Eitner
Frank
F
Walter
Marian
M
Leonhardt
Steffen
S
D000328:Adult; D000465:Algorithms; D001834:Body Water / Q000378:metabolism*; D058266:Dielectric Spectroscopy / Q000379:methods; D017097:Electric Impedance; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D008991:Monitoring, Physiologic / Q000379:methods*; D011187:Posture / Q000502:physiology; D055815:Young Adult
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