The first F-ring modified ciguatoxin analogue showing significant toxicity.
Ciguatoxins, the principal causative toxins of ciguatera seafood poisoning, are potent neurotoxic polycyclic ethers. We report herein the total synthesis of a 10-membered F-ring analogue of 51-hydroxyCTX3C, which constitutes the first example of an F-ring modified ciguatoxin that exhibits potent cytotoxicity as well as mouse acute toxicity.
Ishihara
Yuuki
Y
Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan.
Lee
Nayoung
N
Oshiro
Naomasa
N
Matsuoka
Shigeru
S
Yamashita
Shuji
S
Inoue
Masayuki
M
Hirama
Masahiro
M
D000818:Animals; D036841:Ciguatera Poisoning; D002922:Ciguatoxins / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000633:toxicity; D007274:Injections, Intraperitoneal; D051379:Mice; D008968:Molecular Conformation
D002922:Ciguatoxins