[Plasma proteomic analysis in male normotensive, prehypertensive and hypertensive subjects].
OBJECTIVE
To compare the plasma proteome among male normotensive, prehypertensive, and hypertensive subjects.


METHODS
Plasma proteome was analyzed by two-dimensional electrophoresis combined with MALDI-TOF mass spectrometry in this case-control study among well matched male normotensive, prehypertensive and hypertensive subjects (n = 26 each).


RESULTS
The results showed that there were 22 differentially expressed protein spots among the protein samples derived from the 3 groups which corresponded to 18 proteins associated with inflammation and immunity, lipid metabolism, transport, coagulation and fibrinolysis, cell proliferation and apoptosis, and antioxidation.


CONCLUSIONS
Proteins were differentially expressed in male subjects with various blood pressure levels.
Wang
Zuo-guang
ZG
Department of Hypertension, Beijing Institute of Heart, Lung, Blood Vessel Diseases, Beijing Anzhen Hospital, Attached to Capital University of Medical Sciences, Beijing 100029, China.
Tao
Yan-duo
YD
Liu
Ya
Y
Liu
Jie-lin
JL
Chen
Xin-jun
XJ
Wen
Jie
J
Wen
Shao-jun
SJ
Wu
Zhao-su
ZS
D000328:Adult; D001794:Blood Pressure; D016022:Case-Control Studies; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D058246:Prehypertension / Q000235:genetics* / Q000503:physiopathology*; D040901:Proteomics; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization