Adsorption of proteins on a lipid bilayer.
In our analysis of protein adsorption on a lipid bilayer, the protein surface is considered to contain one or a few charged spots, and the bilayer contains a significant amount of lipids with oppositely charged head groups. After adsorption, a folded protein is assumed to change its shape slightly due to the electrostatic attraction, so that one of the spots forms a flat contact with the oppositely charged lipid heads of the lipid bilayer. With realistic parameters, this model predicts that the contribution of electrostatic interactions to the protein adsorption energy per charged amino acid-lipid pair is 16-25 kJ/mol. Thus, a few (four or five) pairs is sufficient for irreversible adsorption.
Zhdanov
Vladimir P
VP
Department of Applied Physics, Chalmers University of Technology, 412 96 Göteborg, Sweden. zhdanov@catalysis.ru
Kasemo
Bengt
B
D000327:Adsorption; D008051:Lipid Bilayers / Q000737:chemistry* / Q000378:metabolism; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D055672:Static Electricity; D013816:Thermodynamics
D008051:Lipid Bilayers; D011506:Proteins
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