Protein annotation in the era of personal genomics.
Protein annotation provides a condensed and systematic view on the function of individual proteins. It has traditionally dealt with sorting proteins into functional categories, which for example has proven to be successful for the comparison of different species. However, if we are to understand the differences between many individuals of the same species-humans in particular - the focus needs be on the functional impact of individual residue variation. To fulfil the promises of personal genomics, we need to start asking not only what is in a genome but also how millions of small differences between individual genomes affect protein function and in turn human health.
Blicher
Thomas
T
NNF Center for Protein Research, Faculty of Health Sciences, Blegdamsvej 3b, DK-2200 Copenhagen N, Denmark. Thomas.Blicher@cpr.ku.dk
Gupta
Ramneek
R
Wesolowska
Agata
A
Jensen
Lars Juhl
LJ
Brunak
Søren
S
D020816:Amino Acid Motifs; D000595:Amino Acid Sequence; D000818:Animals; D015894:Genome, Human / Q000235:genetics; D023281:Genomics / Q000379:methods*; D006801:Humans; D008969:Molecular Sequence Data; D011506:Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
D011506:Proteins