title: Differential beta-catenin expression between glottic and supraglottic laryngeal carcinoma.
abstract: Glottic carcinomas present with a favorable prognosis comparing to supraglottic. This fact is mainly attributed to differences in anatomical, histological and embryological aspects. It is possible that differential molecular anatomy between the two distinct anatomical entities contributes to this clinical observation as well. The current study intended to evaluate, by immunohistochemistry in paraffin-embedded tissue samples from 97 invasive squamous laryngeal carcinomas, the possible differential expression of crucial molecules for malignant cell's function such as integrin-linked kinase, phosphorylated Akt, E-cadherin, beta-catenin, androgen receptor, estrogen receptor-beta and vimentin between glottic and supraglottic laryngeal carcinomas. We documented a correlation of supraglottic laryngeal carcinomas with high grade (p = 0.001) and enhanced tumor TNM stage (p < 0.001). The supraglottic location was correlated with the abolishment of beta-catenin from the membrane (p = 0.025). However, the diverse anatomical locations are not characterized by statistically significant differential expression of ILK, p-Akt, AR, ER-beta, E-cadherin and vimentin. Our results show that it is possible that molecular factors, such as beta-catenin, are differently expressed in glottic and supraglottic carcinomas, leading to the distinct clinical behavior of those tumors.
authors.affiliation: Anatomy Department, Medical School, University of Patras, Patras, Greece. goulioum@upatras.gr
authors.forename: Anastasios K
authors.initials: AK
authors.lastname: Goulioumis
authors.forename: John
authors.initials: J
authors.lastname: Varakis
authors.forename: Panos
authors.initials: P
authors.lastname: Goumas
authors.forename: Helen
authors.initials: H
authors.lastname: Papadaki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D051176:beta Catenin / Q000378:metabolism*
chemical_list: D051176:beta Catenin
references.citation: Acta Otorrinolaringol Esp. 2007 Dec;58(10):449-53
references.pmid: 18082073
references.citation: J Cell Biochem. 2000 Apr;78(1):141-50
references.pmid: 10797573
references.citation: Am J Otolaryngol. 1998 Mar-Apr;19(2):83-8
references.pmid: 9550437
references.citation: Cell Signal. 2002 May;14(5):381-95
references.pmid: 11882383
references.citation: Cells Tissues Organs. 2005;179(1-2):56-65
references.pmid: 15942193
references.citation: Neoplasma. 1999;46(1):66-71
references.pmid: 10355537
references.citation: Acta Otolaryngol. 1999;119(7):847-51
references.pmid: 10687946
references.citation: Cancer. 2008 May 1;112(9):2088-100
references.pmid: 18327819
references.citation: J Clin Epidemiol. 1989;42(8):755-8
references.pmid: 2788212
references.citation: Virchows Arch. 2008 Nov;453(5):511-9
references.pmid: 18813944
references.citation: Int J Cancer. 2004 Dec 20;112(6):1065-71
references.pmid: 15386361
references.citation: Trends Cell Biol. 1999 Aug;9(8):319-23
references.pmid: 10407411
references.citation: Oncol Rep. 2009 Nov;22(5):1063-8
references.pmid: 19787222
references.citation: Nucl Recept Signal. 2008 Feb 01;6:e001
references.pmid: 18301781
references.citation: Arch Otolaryngol Head Neck Surg. 1991 Jul;117(7):774-8
references.pmid: 1863444
references.citation: Pathology. 2007 Jun;39(3):305-18
references.pmid: 17558857
references.citation: Eur Arch Otorhinolaryngol. 2008 Jan;265(1):79-84
references.pmid: 17909831
references.citation: Eur J Cancer. 2002 Sep;38(13):1717-23
references.pmid: 12175687
references.citation: Otolaryngol Head Neck Surg. 1986 Apr;94(4):512-7
references.pmid: 3086815
references.citation: Cancer Res. 2004 Aug 15;64(16):5683-92
references.pmid: 15313908
references.citation: Biochim Biophys Acta. 2004 Apr 1;1691(1):1-15
references.pmid: 15053919
references.citation: Nat Rev Cancer. 2005 Jan;5(1):51-63
references.pmid: 15630415
references.citation: Virchows Arch. 2004 May;444(5):439-46
references.pmid: 15045586
references.citation: J Laryngol Otol. 2006 Dec;120(12):1042-8
references.pmid: 16995968
references.citation: Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4374-9
references.pmid: 9539744
references.citation: Otolaryngol Head Neck Surg. 2004 Jan;130(1):89-93
references.pmid: 14726916
references.citation: Arch Otolaryngol Head Neck Surg. 2007 Feb;133(2):145-50
references.pmid: 17309983