[Myocardial dysfunction in sepsis--definition and pathogenetic mechanisms].
Sepsis is considered to be the major cause of morbidity and mortality of patients hospitalised in intensive care. It's defined as a systemic inflammatory response of organism to infection. Incidence of myocardial dysfunction in studies with severe sepsis patients is up to two thirds of patients. Cardiac dysfunction shows a continuum from isolated and mild diastolic dysfunction to combined severe diastolic and systolic failure of both ventricles mimicking even cardiogenic shock in some patients. Typical features of septic myocardial dysfunction (SMD) are decrease in ejection fraction (EF) with dilatation ofventricles, e.g. increase in end-diastolic volume (EDV). Reversibility of myocardial dysfunction during a period from 7 to 10 days in survivors is other typical manifestation of SMD. Hence, one can speculate that development of such a type ofSMD as a temporary protective compensatory mechanism could be advantageous for of an individual patient. A large body ofevidence about mechanisms ofSMD was described; endothelial dysfunction with consequent microcirculatory and mitochondrial dysfunction and role of circulating factors are considered to be the most important.
Muriová
K
K
Klinika anesteziologie, resuscitace a intenzivnl medicíny Lékarské fakulty MU a FN Brno. turbo_plum@yahoo.com
Maláska
J
J
Otevrel
F
F
Slezák
M
M
Kratochvíl
M
M
Sevík
P
P
D000818:Animals; D001341:Autonomic Nervous System / Q000503:physiopathology; D009202:Cardiomyopathies / Q000209:etiology / Q000503:physiopathology*; D003326:Coronary Circulation; D016207:Cytokines / Q000502:physiology; D004731:Endotoxins / Q000502:physiology; D006801:Humans; D008929:Mitochondria, Heart / Q000502:physiology; D009206:Myocardium / Q000378:metabolism; D009210:Myofibrils / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology; D018805:Sepsis / Q000150:complications*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D016207:Cytokines; D004731:Endotoxins; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide