title: Predictors of nonalcoholic steatohepatitis in patients with elevated alanine aminotransferase activity.
abstract: Incidence of obesity and hepatic steatosis is increasing worldwide. Almost one quarter of western countries population suffer from non alcoholic fatty liver disease (NAFLD). The aim of this study was to investigate the frequency and predictors of nonalcoholic steatohepatitis (NASH) in patients with unexplained alanine aminotransferase activity elevation (ALT), and therefore avoid unnecessary biopsies in cases of simple steatosis. Earlier studies provided different results and have not answered the question how to distinguish NASH from simple steatosis. Ultrasound (US), computed tomography (CT) and magnetic resonance (MRI) can detect steatosis with great sensitivity level, but not NASH. This study included 50 patients (18 women and 32 men) with mean age 43 +/- 9 years, and with defined selected biochemical, anthropometric and hormone biomarkers. The average BMI was 27.1 +/- 3.81 (kg/m2), insulin resistance HOMA IR 3.89 +/-3.81. All patients underwent liver biopsy and NASH was staged by NASH activity score (NAS) from 1 to 8. Results are compared to pathohistological finding as relevant method. The results show that 90% of patients (n=45) had NAFLD (minimal stage at least), and 15 (30%) had nonalcoholic steatohepatitis (NASH). High triglyceride, low HDL and high ferritin serum levels correspond with NASH. As in earlier studies, insulin resistance as basic mechanism of NAFLD and NASH was confirmed.
authors.affiliation: Department of Gastroenterology, University Hospital Center Split, Split, Croatia. zpuljiz@sve.mo.ba
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Puljiz
authors.forename: Davor
authors.initials: D
authors.lastname: Stimac
authors.forename: Drazen
authors.initials: D
authors.lastname: Kovac
authors.forename: Mario
authors.initials: M
authors.lastname: Puljiz
authors.forename: Andro
authors.initials: A
authors.lastname: Bratanić
authors.forename: Vedran
authors.initials: V
authors.lastname: Kovacić
authors.forename: Dusko
authors.initials: D
authors.lastname: Kardum
authors.forename: Damir
authors.initials: D
authors.lastname: Bonacin
authors.forename: Izet
authors.initials: I
authors.lastname: Hozo
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D015992:Body Mass Index; D005234:Fatty Liver / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005293:Ferritins / Q000097:blood; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D005293:Ferritins; D000410:Alanine Transaminase