title: An efficient method for the synthesis of unsymmetrical 2,2'-bis(pyrrolyl)alkanes.
abstract: A new strategy for the preparation of unsymmetrical 2,2'-bis(pyrrolyl)alkanes has been developed. It involved the condensation of pyrrole derivatives onto N-benzylhydroxylamines in the presence of HCl. This two-step procedure provided access to a wide variety of 2,2'-dipyrromethanes (3a-m). It has also been extended to the synthesis of tripyrromethanes 4a-d and of N-confused dipyrromethanes 6a-d.
authors.affiliation: Département de Chimie Moléculaire (SERCO), UMR-5250, ICMG FR-2607, Université Joseph Fourier, CNRS, BP-53, 38041 Grenoble cedex 9, France.
authors.forename: Marie Laure
authors.initials: ML
authors.lastname: Murat-Onana
authors.forename: Christophe
authors.initials: C
authors.lastname: Berini
authors.forename: Frédéric
authors.initials: F
authors.lastname: Minassian
authors.forename: Nadia
authors.initials: N
authors.lastname: Pelloux-Léon
authors.forename: Jean-Noël
authors.initials: JN
authors.lastname: Denis
mesh_terms: D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000473:Alkanes; D011758:Pyrroles