Fractional compartmental models and multi-term Mittag-Leffler response functions.
Systems of fractional differential equations (SFDE) have been increasingly used to represent physical and control system, and have been recently proposed for use in pharmacokinetics (PK) by (J Pharmacokinet Pharmacodyn 36:165-178, 2009) and (J Phamacokinet Pharmacodyn, 2010). We contribute to the development of a theory for the use of SFDE in PK by, first, further clarifying the nature of systems of FDE, and in particular point out the distinction and properties of commensurate versus non-commensurate ones. The second purpose is to show that for both types of systems, relatively simple response functions can be derived which satisfy the requirements to represent single-input/single-output PK experiments. The response functions are composed of sums of single- (for commensurate) or two-parameters (for non-commensurate) Mittag-Leffler functions, and establish a direct correspondence with the familiar sums of exponentials used in PK.
Verotta
Davide
D
Department of Bioengineering and Therapeutic Sciences, University of California, Box 0912, San Francisco, CA 94143, USA. davide.verotta@ucsf.edu
D008432:Mathematical Computing; D008954:Models, Biological; D010599:Pharmacokinetics
Crit Rev Biomed Eng. 2004;32(1):1-104
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J Pharmacokinet Pharmacodyn. 2009 Apr;36(2):165-78
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J Pharmacokinet Pharmacodyn. 2010 Apr;37(2):119-34
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J Pharmacokinet Pharmacodyn. 2010 Apr;37(2):203-7; discussion 217-20
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