title: Primary meningeal sarcoma with leiomyoblastic differentiation complicating pregnancy.
abstract: Intracranial malignant tumors during pregnancy are rare. Primary meningeal sarcoma with leiomyoblastic differentiation during pregnancy has not been reported. We present the case of a 25-year-old woman in the third trimester of pregnancy with a large intracranial tumor destructing the parietal calvaria and invasion of soft tissues. Histological examination revealed primary meningeal sarcoma with leiomyoblastic differentiation. A gross macroscopical resection of the tumor with removal of the infiltrated parietal calvaria was performed after delivery of a healthy baby through caesarean section. A mass on the head rapidly enlarging during pregnancy should be considered for a malignancy of intracranial origin. Early radiological exams as well as tumor resection followed by staging and multimodality treatment should be urgently performed.
authors.affiliation: Department of Neurosurgery, Hannover Medical School, 30625 Hannover, Germany. hong.bujung@mh-hannover.de
authors.forename: Bujung
authors.initials: B
authors.lastname: Hong
authors.forename: Elvis J
authors.initials: EJ
authors.lastname: Hermann
authors.forename: Bettina
authors.initials: B
authors.lastname: Hollwitz
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Klein
authors.forename: Armen
authors.initials: A
authors.lastname: Agaronjan
authors.forename: Joachim K
authors.initials: JK
authors.lastname: Krauss
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology; D002585:Cesarean Section; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018230:Leiomyoma, Epithelioid / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000150:complications* / Q000473:pathology / Q000628:therapy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000473:pathology* / Q000628:therapy; D011256:Pregnancy Outcome; D012509:Sarcoma / Q000150:complications* / Q000473:pathology / Q000628:therapy