title: Environmental factors in cancer: trichloroethylene and related solvents: science, regulation, and cancer prevention.
abstract: In summary, I have used the case of TCE exposure as an example of: (1) The importance of population-based research to identify and characterize possible environmental risk factors for cancer, and the need for a greater emphasis and proportional increase in public funding of research on prevention as compared to treatment. We need to understand these risks better, and use this information to drive effective public health prevention actions. (2) The imposition of strong restrictions on requests by bona fide researchers for access to data as a barrier to research that could be used to help resolve some of the most controversial issues in TCE epidemiology, in particular, and environmental risks in general, especially access to individual level data including data of event and location of residence. Researchers need ready access these data to more accurately characterize environmental exposures, diseases and their possible associations, and to help develop more effective public health preventive actions, although they should also protect confidentiality. (3) The need for more accurate and comprehensive biomarkers of exposure and disease to better assess possible associations between environmental and occupational exposures and disease; (4) The role of non-scientific concerns in limiting regulatory and advisory agencies in the reevaluation of their positions relative to preventing or lowering allowable exposures to TCE, in light of the growing body of evidence on the possible carcinogenicity of a compound still widely in use, to which many workers, and substantial segments of the general public, are exposed.
authors.affiliation: Division of Environmental Epidemiology, Department of Environmental and Occupational Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School and The Cancer Institute of New Jersey 170 Frelinghuysen Road, Room 234A, Piscataway, NJ 08854, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Wartenberg
mesh_terms: D035843:Biomedical Research; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced* / Q000517:prevention & control; D009784:Occupational Diseases / Q000139:chemically induced / Q000517:prevention & control; D016273:Occupational Exposure / Q000009:adverse effects*; D016272:Occupational Health / Q000331:legislation & jurisprudence; D011159:Population Surveillance; D012997:Solvents / Q000009:adverse effects*; D014241:Trichloroethylene / Q000009:adverse effects*; D014481:United States
chemical_list: D012997:Solvents; D014241:Trichloroethylene
references.citation: J Occup Med. 1978 Mar;20(3):194-6
references.pmid: 627938
references.citation: Environ Health Perspect. 2006 Sep;114(9):1471-8
references.pmid: 16966107
references.citation: J Natl Cancer Inst. 1999 May 19;91(10):854-61
references.pmid: 10340905
references.citation: J Occup Med. 1980 Mar;22(3):158-62
references.pmid: 7365552
references.citation: IARC Monogr Eval Carcinog Risks Hum. 1995;63:33-477
references.pmid: 9139128
references.citation: Toxicology. 2004 Nov 15;204(2-3):187-95
references.pmid: 15388244
references.citation: Environ Health Perspect. 2000 May;108 Suppl 2:161-76
references.pmid: 10807550
references.citation: Environ Health Perspect. 2006 Sep;114(9):1445-9
references.pmid: 16966103
references.citation: Arch Toxicol. 1980 Feb;43(4):237-48
references.pmid: 7387385
references.citation: Toxicol Lett. 2004 Jun 15;151(1):301-10
references.pmid: 15177666
references.citation: Am J Public Health. 1981 Mar;71(3):305-7
references.pmid: 7468868
references.citation: Am J Public Health. 1979 May;69(5):508-11
references.pmid: 434285