Effects of depressive-like behavior of rats on brain glutamate uptake.
Learned helplessness paradigm is a widely accepted animal model of depressive-like behavior based on stress. Glutamatergic system is closely involved with the stress-neurotoxicity in the brain and recently it is pointed to have a relevant role in the pathophysiology of depression disorder. Glutamate uptake is the main mechanism to terminate the glutamatergic physiological activity and to neuroprotection against excitotoxicity. We investigated the profile of glutamate uptake in female rats submitted to the learned helplessness paradigm and to different classes of stress related to the paradigm, in slices of brain cortex, striatum and hippocampus. Glutamate uptake in slices of hippocampus differ between learned helplessness (LH) and non-learned helplessness (NLH) animals immediately persisting up to 21 days after the paradigm. In addition, there were a decrease of glutamate uptake in the three brain structures analyzed at 21 days after the paradigm for LH animals. These results may contribute to better understand the role of the glutamatergic system on the depressive-like behavior.
Almeida
Roberto Farina
RF
Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Thomazi
Ana Paula
AP
Godinho
Graça Fabiana
GF
Saute
Jonas Alex Morales
JA
Wofchuk
Susana Tchernin
ST
Souza
Diogo Onofre
DO
Ganzella
Marcelo
M
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D003863:Depression / Q000378:metabolism* / Q000523:psychology; D005260:Female; D018698:Glutamic Acid / Q000378:metabolism*; D006380:Helplessness, Learned; D006624:Hippocampus / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000378:metabolism* / Q000523:psychology
D018698:Glutamic Acid
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