title: Elective colonic surgery for cancer in the elderly: an investigation into postoperative mortality in English NHS hospitals between 1996 and 2007.
abstract: BACKGROUND
  This study was primarily aimed to quantify perioperative mortality risk in elderly patients undergoing elective colonic resectional surgery. In addition, the safety of minimally invasive colonic surgery in this patient group was evaluated.
  
  
  METHODS
  All patients aged > 75 undergoing elective colonic resection for colorectal malignancy between 1996 and 2007 in English NHS hospitals were included from the Hospital Episode Statistics (HES) dataset.
  
  
  RESULTS
  Between the study dates, 28,746 patients > 75 years underwent elective colonic resection. The national annual number of colonic excisions carried out amongst elderly patients increased from 2188 patients in 1996/7 to 3240 patients in 2006/7. Following adjustment for gender, comorbidity and surgical approach, advancing age was an independent predictor for 30-day mortality (OR 2.47 for patients aged 85-89 vs 75-79, P < 0.001). Use of laparoscopy was a significant predictor of reduced perioperative mortality (OR 0.56, P = 0.003) once adjusted for advancing age, gender and comorbidity. Comparison of 30-day and 1-year postoperative mortality following elective colonic resection in patients aged 90 revealed a large excess of patients dying outside of the immediate perioperative period (10.1% and 26.2% for proximal cancers, respectively; 12.9% and 36.1% for distal colonic resections, respectively).
  
  
  CONCLUSIONS
  Advancing age is an independent risk factor for postoperative death in elderly patients undergoing elective colonic resection for cancer. The risk of death in the elderly is extremely high and surgical decision-making should incorporate the mortality risk that occurs outside the immediate perioperative period. In this national series, patients selected for a laparoscopic procedure were at lower risk of perioperative death than those undergoing the conventional approach.
authors.affiliation: Department of Biosurgery and Surgical and Technology, Imperial College, St Mary's Hospital, London, UK. omarfaiz@aol.com
authors.forename: O
authors.initials: O
authors.lastname: Faiz
authors.forename: A
authors.initials: A
authors.lastname: Haji
authors.forename: A
authors.initials: A
authors.lastname: Bottle
authors.forename: S K
authors.initials: SK
authors.lastname: Clark
authors.forename: A W
authors.initials: AW
authors.lastname: Darzi
authors.forename: P
authors.initials: P
authors.lastname: Aylin
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D003082:Colectomy / Q000379:methods / Q000401:mortality*; D003110:Colonic Neoplasms / Q000601:surgery*; D017558:Elective Surgical Procedures / Q000401:mortality*; D005260:Female; D017052:Hospital Mortality; D006779:Hospitals, Public / Q000706:statistics & numerical data*; D006801:Humans; D010535:Laparoscopy / Q000401:mortality; D008297:Male; D009313:National Health Programs; D006113:United Kingdom / Q000453:epidemiology