title: Abiotrophia defectiva endophthalmitis with retinal involvement and infiltrative keratitis: case report and review of the literature.
abstract: We report the exceptional case of a severe intraocular Abiotrophia defectiva infection which developed after cataract surgery. Retinal involvement as a complication of A. defectiva endophthalmitis or the combination of acute-onset endophthalmitis with infiltrative keratitis caused by this pathogen has not been described. Moreover, our report represents the first documented ocular A. defectiva infection in Germany. A. defectiva was identified using biotyping and 16S ribosomal RNA gene sequence analysis. Despite vigorous antimicrobial therapy and repeated ocular surgery, visual outcome was poor.
authors.affiliation: Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Universitätsklinikum Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany. hor@labor-froreich.de
authors.forename: M A
authors.initials: MA
authors.lastname: Horstkotte
authors.forename: S
authors.initials: S
authors.lastname: Dobinsky
authors.forename: H
authors.initials: H
authors.lastname: Rohde
authors.forename: J K-M
authors.initials: JK
authors.lastname: Knobloch
authors.forename: A
authors.initials: A
authors.lastname: Hassenstein
authors.forename: M
authors.initials: M
authors.lastname: Kalitzky
authors.forename: G
authors.initials: G
authors.lastname: Richard
authors.forename: S J
authors.initials: SJ
authors.lastname: Linke
mesh_terms: D056567:Aerococcaceae / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000378:metabolism; D000368:Aged; D015373:Bacterial Typing Techniques; D002387:Cataract Extraction / Q000009:adverse effects; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D009877:Endophthalmitis / Q000150:complications / Q000382:microbiology*; D005260:Female; D005858:Germany; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis* / Q000382:microbiology; D006801:Humans; D007634:Keratitis / Q000150:complications / Q000382:microbiology*; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D012173:Retinitis / Q000150:complications / Q000382:microbiology*; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D013530:Surgical Wound Infection / Q000382:microbiology
chemical_list: D004269:DNA, Bacterial; D004275:DNA, Ribosomal; D012336:RNA, Ribosomal, 16S
references.citation: Ann Ophthalmol. 1993 Feb;25(2):51-3
references.pmid: 8447648
references.citation: J Bacteriol. 1991 Jan;173(2):697-703
references.pmid: 1987160
references.citation: J Clin Microbiol. 2001 Oct;39(10):3520-3
references.pmid: 11574566
references.citation: J Clin Microbiol. 2004 Sep;42(9):4323-6
references.pmid: 15365035
references.citation: J Cataract Refract Surg. 2007 Jun;33(6):978-88
references.pmid: 17531690
references.citation: Curr Opin Ophthalmol. 2005 Feb;16(1):65-70
references.pmid: 15650583
references.citation: Clin Infect Dis. 2001 May 15;32(10):E140-2
references.pmid: 11317266
references.citation: Clin Infect Dis. 2004 Feb 15;38(4):542-6
references.pmid: 14765348
references.citation: Acta Ophthalmol Scand. 2004 Aug;82(4):463-7
references.pmid: 15291943
references.citation: Enferm Infecc Microbiol Clin. 2004 Jan;22(1):55-6
references.pmid: 14757009
references.citation: Enferm Infecc Microbiol Clin. 2005 Aug-Sep;23(7):455
references.pmid: 16159549
references.citation: Diagn Microbiol Infect Dis. 2004 Mar;48(3):161-5
references.pmid: 15023423
references.citation: J Med Microbiol. 2003 Feb;52(Pt 2):137-140
references.pmid: 12543919
references.citation: J Clin Microbiol. 1999 May;37(5):1564-6
references.pmid: 10203522
references.citation: Ophthalmology. 1991 Feb;98(2):159-69
references.pmid: 2008273
references.citation: Cornea. 2000 Nov;19(6):864-9
references.pmid: 11095068
references.citation: Nature. 1961 Aug 12;191:728-30
references.pmid: 13701753