title: Highly efficient diastereoselective reduction of alpha-fluoroimines.
abstract: A highly selective reduction of alpha-fluoroimines to the corresponding beta-fluoroamines has been developed utilizing trichlorosilane as the reductant. The key aspect of this reaction is the ability of fluorine and nitrogen to activate organosilanes leading to high diastereoselectivity (>100:1) in the product distribution. This new method provides a new avenue for the diastereoselective synthesis of beta-fluorinated amines in good yields and selectivity.
authors.affiliation: Department of Chemistry, Idaho State University, Campus Box 8023, Pocatello, Idaho 83209, USA.
authors.forename: Roy M
authors.initials: RM
authors.lastname: Malamakal
authors.forename: Whitney R
authors.initials: WR
authors.lastname: Hess
authors.forename: Todd A
authors.initials: TA
authors.lastname: Davis
mesh_terms: D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D007097:Imines
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