title: [Gitelman syndrome associated with chondrocalcinosis: description of two cases].
abstract: Gitelman syndrome is a rare inherited tubulopathy, characterized by hypomagnesemia, hypokalemia, metabolic alkalosis, hypocalciuria and hyperreninemic hyperaldosteronism. The clinical spectrum is wide and includes: cramps, myalgias, muscle weakness, until episodes of carpo-podalic spasm, tetania, rhabdomyolysis and paralysis. Some cases have been described in literature underlining the association of this condition with chondrocalcinosis, as a typical example of hypomagnesemia-induced crystal deposition disease. The therapy of Gitelman syndrome consists on the administration of defective electrolytes, although not always effective. We describe two cases of Gitelman syndrome associated with chondrocalcinosis showing the wide range of presentation of this clinical condition.
authors.affiliation: Clinica Reumatologica, Università Politecnica delle Marche, Ospedale "A. Murri", Jesi (AN), Italia. dr.gmarwin@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Gutierrez
authors.forename: F
authors.initials: F
authors.lastname: Silveri
authors.forename: C
authors.initials: C
authors.lastname: Bertolazzi
authors.forename: G
authors.initials: G
authors.lastname: Giacchetti
authors.forename: M
authors.initials: M
authors.lastname: Tardella
authors.forename: L
authors.initials: L
authors.lastname: Di Geso
authors.forename: E
authors.initials: E
authors.lastname: Filippucci
authors.forename: W
authors.initials: W
authors.lastname: Grassi
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use; D002805:Chondrocalcinosis / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000188:drug therapy; D005260:Female; D053579:Gitelman Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007008:Hypokalemia / Q000209:etiology; D007719:Knee Joint / Q000000981:diagnostic imaging; D008274:Magnesium / Q000097:blood; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged; D011859:Radiography; D014463:Ultrasonography
chemical_list: D018712:Analgesics, Non-Narcotic; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D000082:Acetaminophen; D008274:Magnesium; D008775:Methylprednisolone