title: Evaluation of the diagnostic value of a Modified Liquid-Based Cytology using OralCDx Brush in early detection of oral potentially malignant lesions and oral cancer.
abstract: OBJECTIVE
  To determine diagnostic value of modified Liquid Based Brush Biopsy technique.
  
  
  METHODS
  26 oral premalignant and malignant lesions in 25 patients (12 females; 54.23+/-19.77 years and 13 males; 53.77+/-15.43 years) underwent Modified (Liquid Based) Brush Biopsy and scalpel biopsy simultaneously from the same area.
  
  
  RESULTS
  There were 16 positive and 10 negative brush biopsy results, with no inadequate readings. Histological findings were compatible with oral leukoplakia (n=5) with dysplasia, Oral lichen planus and lichenoid reaction (n=7) (with or without dysplasia) oral squamous cell carcinoma (n=11),verrucous carcinoma (n=1) and granular cell tumors (n=2). Sensitivity, specificity, positive predictive value, negative predictive value, positive diagnostic likelihood ratio (LR+) and negative diagnostic likelihood ratio (LR-) were 88.8%, 100%, 100%, 80%, infinity and 0.11 respectively (no false positive results).
  
  
  CONCLUSIONS
  It is the first attempt to do LBC with a specialized oral brush. Our results show that modified technique is a useful tool for screening of oral premalignant and malignant lesions.
authors.affiliation: Dental Research Center of Mashhad Dental School, Mashhad University of Medical Sciences, Mashhad, Khorasane Razavi State, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Delavarian
authors.forename: Nooshin
authors.initials: N
authors.lastname: Mohtasham
authors.forename: Pegah
authors.initials: P
authors.lastname: Mosannen-Mozafari
authors.forename: Atessa
authors.initials: A
authors.lastname: Pakfetrat
authors.forename: Mohammad-Taghi
authors.initials: MT
authors.lastname: Shakeri
authors.forename: Rasoul
authors.initials: R
authors.lastname: Ghafoorian-Maddah
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy / Q000379:methods; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology*; D055815:Young Adult