New neuroprotective dibenzylbutane lignans isolated from Machilus thunbergii.
Two new dibenzylbutane lignans, namely rel-methyl (2S)-2-hydroxy-2-2'-((2''R,3''R)-4''-guaiacyl-2'',3''dimethylbutyl)-5'-oxo-2',5'-dihydro-2-furanylethnoate (1) and rel-methyl (2S)-2-hydroxy-2-2'-((2''R,3''S)-4''-guaiacyl-2'',3''dimethylbutyl)-5'-oxo-2',5'-dihydro-2-furanylethnoate (2), were isolated from the bark of Machilus thunbergii. Their structures were elucidated by spectral analysis. These two lignans exerted significant neuroprotective activities against glutamate-induced neurotoxicity in primary cultures of rat cortical cells. Compounds 1 and 2 represent a new type of lignan skeleton that has not been reported so far from nature.
Ma
Choong Je
CJ
School of Biotechnology and Bioengineering, Kangwon National University, Korea.
Sung
Sang Hyun
SH
Kim
Young Choong
YC
D000818:Animals; D001681:Biological Assay; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D005260:Female; D019770:Lauraceae / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification*; D018696:Neuroprotective Agents / Q000302:isolation & purification*; D024301:Plant Bark / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
D017705:Lignans; D018696:Neuroprotective Agents