title: Plasma levels of inter-alpha inhibitor proteins in children with acute Dengue virus infection.
abstract: BACKGROUND
  Inter-alpha inhibitor proteins (IaIp) belong to a family of protease inhibitors that are involved in the haemostatic and the vascular system. Dengue viruses (DENV) infections are characterized by coagulopathy and increased vascular permeability. In this study we measured the concentration of IaIp during DENV infections and evaluated its potential as a biomarker.
  
  
  RESULTS
  Concentrations of IaIp were measured in patients with acute DENV infections using a quantitative, competitive enzyme linked immunoassay. Concentrations of IaIp measured in pediatric patients suffering from severe DENV infections were significantly lower than in healthy controls.
  
  
  CONCLUSIONS
  This is the first report to demonstrate changes in concentration of IaIp during viral infections. The data also highlight the potential of IaIp as a biological marker for severity of DENV infections.
authors.affiliation: Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.
authors.forename: Penelope
authors.initials: P
authors.lastname: Koraka
authors.forename: Yow-Pin
authors.initials: YP
authors.lastname: Lim
authors.forename: Michael D
authors.initials: MD
authors.lastname: Shin
authors.forename: Tatty E
authors.initials: TE
authors.lastname: Setiati
authors.forename: Albert T A
authors.initials: AT
authors.lastname: Mairuhu
authors.forename: Eric C M
authors.initials: EC
authors.lastname: van Gorp
authors.forename: Augustinus
authors.initials: A
authors.lastname: Soemantri
authors.forename: Albert D M E
authors.initials: AD
authors.lastname: Osterhaus
authors.forename: Byron E E
authors.initials: BE
authors.lastname: Martina
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000510:Alpha-Globulins / Q000032:analysis*; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000097:blood / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods / Q000592:standards; D005260:Female; D006801:Humans; D008297:Male
chemical_list: D000510:Alpha-Globulins; D015415:Biomarkers; C011877:inter-alpha-inhibitor
references.citation: J Med Virol. 2000 Oct;62(2):267-77
references.pmid: 11002258
references.citation: Infect Immun. 2005 Aug;73(8):5101-5
references.pmid: 16041026
references.citation: J Med Virol. 2004 Mar;72(3):445-50
references.pmid: 14748068
references.citation: J Clin Microbiol. 2001 Dec;39(12):4332-8
references.pmid: 11724841
references.citation: Proteomics. 2006 May;6(9):2874-85
references.pmid: 16596706
references.citation: J Med Virol. 2002 Aug;67(4):549-54
references.pmid: 12116003
references.citation: BMC Infect Dis. 2007 Mar 26;7:22
references.pmid: 17386105
references.citation: Crit Care Med. 2004 Aug;32(8):1747-52
references.pmid: 15286553
references.citation: J Infect Dis. 2003 Sep 15;188(6):919-26
references.pmid: 12964125
references.citation: J Immunol. 2007 Sep 15;179(6):4187-92
references.pmid: 17785858
references.citation: J Immunol. 1996 Feb 15;156(4):1609-15
references.pmid: 8568267
references.citation: J Pediatr. 2009 Apr;154(4):620-622.e1
references.pmid: 19324226
references.citation: Arch Med Res. 2005 Sep-Oct;36(5):425-35
references.pmid: 16099317