title: Effect of treatment with cyproterone acetate on uterine bleeding at the beginning of GnRH analogue therapy in girls with idiopathic central precocious puberty.
abstract: BACKGROUND
  The flare-up effect of GnRH analogues may cause transient uterine bleeding in girls affected with idiopathic central precocious puberty (ICPP).
  
  
  OBJECTIVE
  To assess the incidence of endometrial bleeding and verify whether pretreatment with cyproterone acetate could counteract it.
  
  
  METHODS
  Fifty-four girls affected by ICPP were divided into 2 groups. The first group (30 girls) was treated with triptorelin (3.75 mg, i.m. injection) every 28 days. The second group (24 girls) was treated with cyproterone acetate and triptorelin: cyproterone acetate (50 mg/m(2)) was administered every day for 8 weeks, and triptorelin (3.75 mg) was commenced 4 weeks after starting the cyproterone, then the intramuscular injection of triptorelin was repeated every 28 days.
  
  
  RESULTS
  Eight of 54 girls (15%) had mild withdrawal bleeding. There were no differences in incidence between groups 1 and 2. Girls with pubertal uterus at pelvic ultrasound had a higher incidence of uterine bleeding than girls with infantile uterus (25 vs. 7%), but this difference was not significant.
  
  
  CONCLUSIONS
  Co-administration of cyproterone acetate and GnRH analogues does not significantly decrease the incidence of uterine bleeding.
authors.affiliation: Paediatric Endocrinology Unit, Department of Paediatrics, University of Florence, AOU Meyer, Florence, Italy. seminara@unifi.it
authors.forename: S
authors.initials: S
authors.lastname: Seminara
authors.forename: L
authors.initials: L
authors.lastname: Nanni
authors.forename: M
authors.initials: M
authors.lastname: Generoso
authors.forename: S
authors.initials: S
authors.lastname: Mirri
authors.forename: V
authors.initials: V
authors.lastname: Leonardi
authors.forename: T
authors.initials: T
authors.lastname: Slabadzianiuk
authors.forename: M L
authors.initials: ML
authors.lastname: Vetrano
authors.forename: A
authors.initials: A
authors.lastname: Buongiorno
authors.forename: S
authors.initials: S
authors.lastname: Losi
authors.forename: F
authors.initials: F
authors.lastname: Galluzzi
mesh_terms: D002648:Child; D002675:Child, Preschool; D017373:Cyproterone Acetate / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011629:Puberty, Precocious / Q000188:drug therapy*; D012189:Retrospective Studies; D017329:Triptorelin Pamoate / Q000008:administration & dosage / Q000627:therapeutic use*; D014463:Ultrasonography; D014592:Uterine Hemorrhage / Q000517:prevention & control*; D014599:Uterus / Q000000981:diagnostic imaging / Q000187:drug effects
chemical_list: D017329:Triptorelin Pamoate; D017373:Cyproterone Acetate