title: Platelet-rich plasma in sinus augmentation procedures: a systematic literature review: Part II.
abstract: BACKGROUND
  Although platelet-rich plasma (PRP) has been extensively studied for over a decade, there are no definitive reports, which prove the benefit of using PRP in sinus augmentation procedures. In addition, no systematic literature review has been done to report the benefit of treatment outcome in patients who received PRP in conjunction with bone/bone substitutes in maxillary sinus augmentation procedures. Therefore, it can be rightly stated that evidence for an adjunctive benefit of using PRP with bone grafts in sinus augmentation procedures is equivocal and inconclusive.
  
  
  OBJECTIVE
  : The objective of this systematic literature review was to examine this literature in determining whether PRP with bone and bone substitutes leads to more rapid and effective bone regeneration clinically, radiographically, and histologically with sinus augmentation procedures and was there any clinical data parallel to animal experiments providing clinical evidence in sinus augmentation procedures?
  
  
  METHODS
  A systematic review of randomized clinical trials of at least 6 months duration was conducted comparing PRP and bone/bone substitutes (test group) to bone/bone substitutes (control group) alone. Electronic databases such as MEDLINE and CENTRAL (Cochrane central register of controlled clinical trials) were searched for relevant articles. The reference list of all included articles was searched along with unpublished clinical trials whose abstracts were available.
  
  
  RESULTS
  Although, there is a lack of human studies, which show benefit of using PRP in conjunction with bone grafting materials, it can be stated that use of PRP does lead to early regeneration and reduction in healing time of soft and hard tissues. However, no significant statistical or clinical benefit was reported from studies that would satisfy the inclusion criteria. This study answers the question very clearly that at this point of time, there is no human study that strongly supports the benefit of using PRP in sinus augmentation procedures.
  
  
  CONCLUSIONS
  There is a paucity of clinically controlled trials regarding benefits of PRP in sinus augmentation procedures. Theoretically, it seems to have significant beneficial effects on the soft and hard tissue healing; however, the disparity in study design, surgical techniques, and different outcome assessment variables used, makes it difficult to assess the practical benefit of its clinical use. Although no obvious positive effects of PRP on healing of bone graft material in maxillary sinus augmentation procedures were noted, the handling of the particulate bone grafts was improved.
authors.affiliation: Division of Periodontology, Eastman Dental Center, Rochester, NY 14620, USA.
authors.forename: Navneet S
authors.initials: NS
authors.lastname: Arora
authors.forename: Thaminda
authors.initials: T
authors.lastname: Ramanayake
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Ren
authors.forename: Georgios E
authors.initials: GE
authors.lastname: Romanos
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods*; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use; D016025:Bone Transplantation; D006801:Humans; D008437:Maxilla / Q000601:surgery; D008443:Maxillary Sinus / Q000601:surgery*; D053657:Platelet-Rich Plasma; D016032:Randomized Controlled Trials as Topic
chemical_list: D018786:Bone Substitutes