RAD51 135G>C polymorphism contributes to breast cancer susceptibility: a meta-analysis involving 26,444 subjects.
RAD51 plays a key role in homologous recombination repair of double-stranded DNA breaks which may cause chromosomal breaks and genomic instability. We performed a meta-analysis of 9 epidemiological studies involving 13,241 cases and 13,203 controls that examined the association between RAD51 135G>C polymorphism and breast cancer. No significant association of RAD51 135G>C polymorphism with breast cancer was found in overall and European populations. However, after the studies which did not fulfill Hardy-Weinberg equilibrium were excluded, we observed an overall significant increased breast cancer risk (for the recessive model CC vs. GG/CG: OR = 1.35, 95% CI = 1.05-1.74, P (heterogeneity) = 0.06). In summary, our meta-analysis suggested the RAD51 135G > C polymorphism may contribute to breast cancer susceptibility.
Wang
Zhanwei
Z
Department of Epidemiology and Biostatistics, Nanjing Medical University, Nanjing, China.
Dong
Hairong
H
Fu
Yuanyuan
Y
Ding
Haixia
H
D020121:5' Untranslated Regions; D001943:Breast Neoplasms / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D016014:Linear Models; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D051135:Rad51 Recombinase / Q000235:genetics*; D018570:Risk Assessment; D012307:Risk Factors
D020121:5' Untranslated Regions; C495153:RAD51 protein, human; D051135:Rad51 Recombinase