title: Triethanolamine-mediated palladium-catalyzed regioselective C-2 direct arylation of free NH-pyrroles.
abstract: An atom-economical phosphane-free palladium-catalyzed direct C-2 arylation of unactivated free NH-pyrroles is devised. This method provides a straightforward route to a wide variety of substituted 2-aryl-1H-pyrroles from readily accessible starting materials. Iodoarenes bearing electron-withdrawing and electron-donating substituents are tolerated under the presented reaction conditions. The scope of the reaction is also expanded to N-aryl and -alkylpyrroles albeit in lower yields.
authors.affiliation: School of Chemistry, University College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran. jafarpur@khayam.ut.ac.ir
authors.forename: Farnaz
authors.initials: F
authors.lastname: Jafarpour
authors.forename: Soraya
authors.initials: S
authors.lastname: Rahiminejadan
authors.forename: Hamideh
authors.initials: H
authors.lastname: Hazrati
mesh_terms: D002384:Catalysis; D004983:Ethanolamines / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry; D008956:Models, Chemical; D010165:Palladium / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D004983:Ethanolamines; D006847:Hydrocarbons, Iodinated; D011758:Pyrroles; D010165:Palladium; C009546:triethanolamine