title: New lobane and cembrane diterpenes from two comorian soft corals.
abstract: Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively. Bioassay-guided fractionations provided a known antitumor promoter cembrane diterpenoid, (+)-sarcophytol-A (1), along with a new lobane diterpenoid, carbomethoxyfuscol (2), from Sarcophyton sp., and a new cembranoid, crassumolide E (3), from Lobophytum sp. The structures of compounds 1-3 were determined by spectroscopic analysis and by comparison of the spectral data with previously reported values. The cembranoid 3 was found to exhibit a moderate inhibitory effect on acetylcholinesterase.
authors.affiliation: Laboratoire de Chimie des Biomolécules et de l'Environnement, Centre de Phytopharmacie, Université de Perpignan, Perpignan Cedex, France. sabelle.bonnard@univ-perp.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bonnard
authors.forename: Sabina B
authors.initials: SB
authors.lastname: Jhaumeer-Laulloo
authors.forename: Nataly
authors.initials: N
authors.lastname: Bontemps
authors.forename: Bernard
authors.initials: B
authors.lastname: Banaigs
authors.forename: Maurice
authors.initials: M
authors.lastname: Aknin
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D001156:Artemia; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy
chemical_list: D002800:Cholinesterase Inhibitors; D004224:Diterpenes
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