Expression of STAMP2 in monocytes associates with cardiovascular alterations.
BACKGROUND
Metabolic and inflammatory pathways crosstalk at many levels. In this study, we aimed to investigate the expression of six-transmembrane protein of prostate 2 (STAMP2) in macrophages and tried to search for the association between the decreased STAMP2 expression, if any, and carotid atherosclerosis as well as cardiac adaptations.


METHODS
A total of 97 unrelated Chinese subjects were recruited including 48 subjects with metabolic syndrome (MetS) and 49 controls. Clinical and biochemical characteristics were collected from subjects, with quantification of STAMP2 in monocyte/macrophages. All subjects underwent ultrasonography.


RESULTS
STAMP2 expression in macrophages was significantly decreased in MetS as compared with the control group (10.25 +/- 9.20 vs. 15.20 +/- 9.18, P = 0.009), especially in women patients. Partial correlation analysis showed that STAMP2 expression in macrophages correlated with BMI (r = -0.375, P = 0.045), age (r = 0.414, P = 0.026) and HDL (r = 0.377, P = 0.044) after controlling for systolic blood pressure (SBP). Furthermore, STAMP2 expression was correlated with PI (r = -0.454, P = 0.013), LVEF (r = -0.503, P = 0.005), LA-ESR (r = -0.424, P = 0.022), LA-S (r = 0.469, P = 0.010) and mitral E/A ratio (r = 0.492, P = 0.005) after controlling for SBP. Still, in multivariable analysis, STAMP2 expression was independently associated with IMT(mean), PI and mitral E/A ratio.


CONCLUSIONS
In MetS patients, especially women patients, STAMP2 expression was down-regulated in peripheral blood mononuclear cell, which was correlated with carotid atherosclerosis and cardiac adaptation.
Wang
Zhi-Hao
ZH
Qilu Hospital of Shandong University, Ji'nan, China.
Zhang
Wei
W
Gong
Hui-Ping
HP
Guo
Zhong-Xiu
ZX
Zhao
Jing
J
Shang
Yuan-Yuan
YY
Feng
Jin-Bo
JB
Zhang
Yun
Y
Zhong
Ming
M
D000367:Age Factors; D044466:Asian People; D050197:Atherosclerosis / Q000378:metabolism; D015992:Body Mass Index; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D002340:Carotid Artery Diseases / Q000378:metabolism*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000032:analysis; D008264:Macrophages / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000378:metabolism*; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D015999:Multivariate Analysis; D010088:Oxidoreductases / Q000378:metabolism*; D012307:Risk Factors; D012737:Sex Factors; D014463:Ultrasonography; D016277:Ventricular Function, Left / Q000502:physiology
D008075:Lipoproteins, HDL; D008565:Membrane Proteins; D010088:Oxidoreductases; C503310:STEAP4 protein, human