title: Impact of smoking on bone mineral density and bone metabolism in elderly men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study.
abstract: Our cross-sectional analysis of 1,576 men aged ≥65 years examined smoking effects on bone status. Number of smoking years was associated with decreased bone mineral density (BMD), after adjusting for age, height, weight, and number of cigarettes smoked daily. Smoking did not affect biochemical marker serum values for bone turnover.
  
  
  BACKGROUND
  The impact of smoking on bone status in men has not been conclusively established. We examined how smoking and its cessation influence bone status and metabolism in men.
  
  
  METHODS
  We analyzed 1,576 men among a baseline survey of Japanese men aged ≥65 years, the Fujiwara-kyo Osteoporosis Risk in Men study, conducted during 2007-2008.
  
  
  RESULTS
  Lumbar spine (LS) BMD values among never, former, and current smokers were 1.045 ± 0.194, 1.030 ± 0.189, and 1.001 ± 0.182 g/cm(2) (P = 0.005), respectively, while total hip (TH) BMD values were 0.888 ± 0.120, 0.885 ± 0.127, and 0.870 ± 0.124 (P = 0.078), respectively. The significant trend for LS BMD remained after adjusting for the covariates; age, height, weight, physical activity, milk consumption, and drinking habit (P = 0.036). Among never and ever (current and former) smokers, LS and TH BMD decreased with the number of pack years or the number of smoking years, respectively, adjusted for those covariates. Among ever smokers, LS and TH BMD decreased with the number of smoking years after adjusting for age, height, weight, and number of cigarettes smoked daily. Smoking did not reveal significant effect for serum osteocalcin or tartrate resistant acid phosphatase isoenzyme 5b.
  
  
  CONCLUSIONS
  The impact of smoking on bone status is mainly associated with the number of smoking years in elderly men.
authors.affiliation: Department of Public Health, Kinki University School of Medicine, 377-2, Oono-higasi, Osaka-sayama, Osaka, 589-8511, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Tamaki
authors.forename: M
authors.initials: M
authors.lastname: Iki
authors.forename: Y
authors.initials: Y
authors.lastname: Fujita
authors.forename: K
authors.initials: K
authors.lastname: Kouda
authors.forename: A
authors.initials: A
authors.lastname: Yura
authors.forename: E
authors.initials: E
authors.lastname: Kadowaki
authors.forename: Y
authors.initials: Y
authors.lastname: Sato
authors.forename: J S
authors.initials: JS
authors.lastname: Moon
authors.forename: K
authors.initials: K
authors.lastname: Tomioka
authors.forename: N
authors.initials: N
authors.lastname: Okamoto
authors.forename: N
authors.initials: N
authors.lastname: Kurumatani
mesh_terms: D000135:Acid Phosphatase / Q000097:blood; D000368:Aged; D015415:Biomarkers / Q000097:blood; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism*; D003430:Cross-Sectional Studies; D006621:Hip Joint / Q000503:physiopathology; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008159:Lumbar Vertebrae / Q000503:physiopathology; D008297:Male; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D012907:Smoking / Q000009:adverse effects / Q000378:metabolism / Q000503:physiopathology*; D016540:Smoking Cessation; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D015675:Osteocalcin; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase
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