PROTIS: use of combined biomarkers for providing diagnostic information on disease states.
We describe herein PROTIS, a software package that allows for the combination of urine biomarkers (proteins, small molecules, cells) to provide accurate diagnostic information on renal disease states. Such an approach exemplifies the advantage conferred by using multiple markers, and can be generalized for identification of biomarker signatures to separate distinct sample groups.
Hofmann
Walter
W
Institüt für Klinische Chemie, Städtisches Klinikum München GmbH, München, Germany.
Sedlmeir-Hofmann
Cornelia
C
Ivandić
Miroslav
M
Ruth
Dagmar
D
Luppa
Peter
P
D000293:Adolescent; D015415:Biomarkers / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood / Q000652:urine; D055316:Cystatin C / Q000097:blood; D003937:Diagnosis, Differential; D005260:Female; D005919:Glomerular Filtration Rate; D006417:Hematuria / Q000175:diagnosis / Q000652:urine; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D007674:Kidney Diseases / Q000175:diagnosis* / Q000378:metabolism / Q000503:physiopathology / Q000652:urine; D008297:Male; D011507:Proteinuria / Q000378:metabolism; D012984:Software; D055815:Young Adult
D015415:Biomarkers; D055316:Cystatin C; D003404:Creatinine