title: Ophthalmic disorders in adult lymphoma patients in Africa.
abstract: BACKGROUND
  Ocular manifestations of lymphoma are rare events. Most reports of ocular involvement in lymphoma are case reports or reports of a few patients.
  
  
  OBJECTIVE
  To determine the ophthalmic disorders in adult, African, lymphoma patients.
  
  
  METHODS
  A prospective study of ocular disorders in adult patients with lymphoma was conducted at the University of Benin Teaching Hospital, Benin City, Nigeria, between July 2004 and June 2007.
  
  
  METHODS
  The patients were interviewed and examined by the authors and the ocular findings recorded.
  
  
  METHODS
  Data was analyzed on computer with the aid of the Instat GraghPad v2.05a statistical package software. The mean, standard deviation, Mann-Whitney U-statistic and P value were calculated.
  
  
  RESULTS
  A total of 111 patients with hematological malignancies were seen over a period of three years of which 62 (55.85%) had lymphomas. Of these, 51(82.3%) were non-Hodgkin's lymphoma and 11(17.7%) were Hodgkin's lymphoma. Ocular disorders occurred in 16 patients (31.4%) with non-Hodgkin's lymphoma and none of the patients with Hodgkin's lymphoma (Mann-Whitney U-statistic is equal to 7.500, U' is equal to161.50, P< 0.0001). The ocular disorders due to non-Hodgkin's lymphoma were seen as - proptosis in six patients (11.8%), retinopathies in three (5.9%), conjunctival infiltration in three (5.9%), optic atrophy in two (3.9%), keratoconjunctivitis in one (two per cent), desquamating nodular lid lesions in one (two per cent), papilloedema in one (two per cent), and upper lid mass in one (two per cent). Four patients (6.5%) had monocular blindness.
  
  
  CONCLUSIONS
  Ophthalmic disorders are relatively common in non-Hodgkin's lymphoma. Ophthalmic evaluation is needed in these patients for early identification and treatment of potentially blinding conditions.
authors.affiliation: Department of Ophthalmology, University of Benin Teaching Hospital, PMB 1111, Benin City, Edo State, Nigeria.
authors.forename: Afekhide E
authors.initials: AE
authors.lastname: Omoti
authors.forename: Caroline E
authors.initials: CE
authors.lastname: Omoti
authors.forename: Rita O
authors.initials: RO
authors.lastname: Momoh
references.citation: Surv Ophthalmol. 2001 May-Jun;45(6):463-71
references.pmid: 11425352
references.citation: Ann Afr Med. 2007 Sep;6(3):89-93
references.pmid: 18240494
references.citation: Klin Monbl Augenheilkd. 2004 May;221(5):401-3
references.pmid: 15162291
references.citation: Klin Oczna. 2004;106(6):783-7
references.pmid: 15787182
references.citation: Ophthalmology. 2003 May;110(5):1057-60
references.pmid: 12750114
references.citation: Can J Ophthalmol. 2005 Oct;40(5):623-6
references.pmid: 16391629
references.citation: Surv Ophthalmol. 2008 May-Jun;53(3):285-95
references.pmid: 18501272
references.citation: Ann Oncol. 2000;11 Suppl 1:3-10
references.pmid: 10707771
references.citation: Med J Malaysia. 2003 Oct;58(4):546-55
references.pmid: 15190631
references.citation: Curr Opin Ophthalmol. 2002 Dec;13(6):411-8
references.pmid: 12441846
references.citation: Ophthalmology. 1999 Jul;106(7):1339-44
references.pmid: 10406618
references.citation: Ophthalmology. 2002 Sep;109(9):1717-22
references.pmid: 12208722
references.citation: Int J Lab Hematol. 2007 Dec;29(6):426-32
references.pmid: 17988297
references.citation: Clin Lab Haematol. 2005 Oct;27(5):302-6
references.pmid: 16178909
references.citation: Ann Hematol. 1997 Apr;74(4):163-8
references.pmid: 9174543