title: Synthesis of beta-hydroxyphosphonate and 1,2-dihydroxy acyclic nucleoside analogs via 1,3-dipolar cycloaddition strategy.
abstract: A convenient synthetic approach toward nucleoside analogs where beta-hydroxyphosphonate- or 1,2-dihydroxy units are connected to the nucleic acid base through a triazole spacer is discussed.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai, India.
authors.forename: M
authors.initials: M
authors.lastname: Ganesan
authors.forename: K M
authors.initials: KM
authors.lastname: Muraleedharan
mesh_terms: D002625:Chemistry, Organic / Q000379:methods*; D018360:Crystallography, X-Ray; D003500:Cyclization; D009690:Nucleic Acid Conformation; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry*; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D011409:Propylene Glycols / Q000138:chemical synthesis* / Q000737:chemistry; D011687:Purines / Q000138:chemical synthesis* / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000737:chemistry
chemical_list: D009705:Nucleosides; D063065:Organophosphonates; D011409:Propylene Glycols; D011687:Purines; D011743:Pyrimidines; D014230:Triazoles