The role of perfluorocarbon in organ preservation.
Perfluorocarbons (PFCs) are inert solutions that have a high capacity for dissolving oxygen. There has been a continuing level of research into the delivery of oxygen during solid organ preservation with the use of PFCs. The one- and two-layer methods have been used as static storage techniques, proving particularly successful for pancreas preservation. They can also be formulated as an emulsion for continual perfusion or as a simple flush solution. The success of PFCs in organ preservation seems to be somewhat organ and species dependant, and further experimental evidence is needed to establish their application.
Hosgood
Sarah A
SA
Nicholson
Michael L
ML
D000241:Adenosine; D000493:Allopurinol; D000818:Animals; D002477:Cells / Q000378:metabolism; D004285:Dogs; D004655:Emulsions; D005466:Fluorocarbons / Q000378:metabolism / Q000627:therapeutic use*; D005978:Glutathione; D006321:Heart / Q000502:physiology; D006801:Humans; D007035:Hypothermia; D007328:Insulin; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D009926:Organ Preservation / Q000379:methods*; D019188:Organ Preservation Solutions; D010477:Perfusion / Q000379:methods; D011817:Rabbits; D011887:Raffinose; D051381:Rats; D013696:Temperature
D004655:Emulsions; D005466:Fluorocarbons; D007328:Insulin; D019188:Organ Preservation Solutions; C055206:University of Wisconsin-lactobionate solution; D000493:Allopurinol; D005978:Glutathione; D000241:Adenosine; D011887:Raffinose