title: Preclinical studied of general toxic properties of preparations containing ultralow doses of antibodies to endogenous regulators.
abstract: Preclinical study of the safety of 6 preparations containing ultralow doses of antibodies to endogenous regulators showed that they are relatively safe, are well tolerated by animals in doses more than 1000-fold surpassing the therapeutic dose for humans, and produce no general toxic effect on the organism of laboratory animals.
authors.affiliation: Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Tomsk.
authors.forename: G V
authors.initials: GV
authors.lastname: Karpova
authors.forename: T I
authors.initials: TI
authors.lastname: Fomina
authors.forename: T V
authors.initials: TV
authors.lastname: Vetoshkina
authors.forename: T Yu
authors.initials: TY
authors.lastname: Dubskaya
authors.forename: O L
authors.initials: OL
authors.lastname: Voronova
authors.forename: E A
authors.initials: EA
authors.lastname: Timina
authors.forename: E V
authors.initials: EV
authors.lastname: Abramova
authors.forename: L A
authors.initials: LA
authors.lastname: Ermolaeva
authors.forename: A V
authors.initials: AV
authors.lastname: Perova
mesh_terms: D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000633:toxicity*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D051379:Mice; D011817:Rabbits; D051381:Rats; D018675:Toxicity Tests
chemical_list: D000906:Antibodies; D000911:Antibodies, Monoclonal; C503436:Artrofoon; C534505:IMPAZA; C533336:afala; C547732:anaferon