title: Development and evaluation of a chloramphenicol hypertonic ophthalmic solution.
abstract: Hypertonic ophthalmic solutions are used to treat ocular diseases associated with edema. In this study, we developed a chloramphenicol hypertonic ophthalmic solution. These drops were developed based on the cosolvency and additional dielectric constant concepts. Two different solvents: PEG 300 and glycerol were used as cosolvents. Solubility curves were plotted. Based on the solubility curves, two different solutions were selected. These solutions were evaluated for physical parameters and accelerated stability. The results indicated that chloramphenicol was stable in these formulations. The selected blend of solutions was hypertonic. Thus, the solubility and stability of chloramphenicol was enhanced using a cosolvency technique so as to develop a chloramphenicol hypertonic ophthalmic solution.
authors.affiliation: Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam - 530 003, India.
authors.forename: A V
authors.initials: AV
authors.lastname: Jithan
authors.forename: C Krishna
authors.initials: CK
authors.lastname: Mohan
authors.forename: M
authors.initials: M
authors.lastname: Vimaladevi
references.citation: Aust Vet J. 1991 Jan;68(1):8-9
references.pmid: 2018459
references.citation: J Pharm Sci. 1972 Jul;61(7):1160-2
references.pmid: 5044821
references.citation: Farmatsiia. 1977 Nov-Dec;26(6):30-3
references.pmid: 598523
references.citation: J Pharm Sci. 1976 Oct;65(10):1488-94
references.pmid: 978408