Synthesis and alpha-glucosidase inhibitory activity of oleanolic acid derivatives.
Glucosidations of oleanolic acid (1) and its dihydroxy-olide derivatives (2) were carried out to provide eight glycosides. All synthesized compounds were evaluated by in vitro alpha-glucosidase inhibitory activity assay. 3-Acetyl dihydroxy-olide oleanolic derivative 15 showed the most potent inhibitory effect. Structure-activity relationships within these compounds are discussed.
Qian
Shan
S
Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, China.
Li
Jiao Hai
JH
Zhang
Yu Wei
YW
Chen
Xin
X
Wu
Yong
Y
D065089:Glycoside Hydrolase Inhibitors; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D065089:Glycoside Hydrolase Inhibitors; D009828:Oleanolic Acid