title: A strong inorganic acid-initiated methacrylate polymerization strategy for room temperature preparation of monolithic columns for capillary electrochromatography.
abstract: A facile strong inorganic acid-initiated methacrylate polymerization strategy was developed for fabricating monolithic columns at room temperature. The prepared monoliths were characterized by FTIR spectrometry, mercury intrusion porosimeter and SEM, while their performance was evaluated by CEC for the separation of various types of compounds including alkyl benzenes, polycyclic aromatic hydrocarbons, nonsteroidal anti-inflammatory drugs, anilines, and nitrophenol isomers. The column-to-column and batch-to-batch reproducibility for the prepared monoliths in terms of the RSD of EOF flow velocity, retention factor, and the minimum plate height of naphthalene ranged from 3.4 to 12.4%. The fabricated monoliths gave excellent performance for the separation of the test neutral compounds with the theoretical plates of 170,000-232,000 plates per meter for thiourea, and 77,400-112,300 plates per meter for naphthalene. The proposed strong inorganic acid-initiated methacrylate polymerization strategy is a promising alternative for fabricating organic polymer-based monoliths.
authors.affiliation: Research Center for Analytical Sciences, College of Chemistry, Nankai University, Tianjin, PR China.
authors.forename: Man-Man
authors.initials: MM
authors.lastname: Wang
authors.forename: He-Fang
authors.initials: HF
authors.lastname: Wang
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Jiang
authors.forename: Shan-Wei
authors.initials: SW
authors.lastname: Wang
authors.forename: Xiu-Ping
authors.initials: XP
authors.lastname: Yan
mesh_terms: D053801:Capillary Electrochromatography / Q000379:methods*; D003511:Cyclohexanols / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008689:Methacrylates / Q000737:chemistry*; D009281:Naphthalenes / Q000737:chemistry; D017942:Nitric Acid / Q000737:chemistry*; D009930:Organic Chemicals; D015203:Reproducibility of Results; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
chemical_list: D003511:Cyclohexanols; D008689:Methacrylates; D009281:Naphthalenes; D009930:Organic Chemicals; C031721:naphthalene; D017942:Nitric Acid