MicroRNA-146a and human disease.
MicroRNAs (MiRNAs) belong to a class of small non-coding regulatory RNAs that act through repression of protein expression at post-transcriptional level and emerge to play important roles in many physiological and pathophysiological processes. MiR-146a is a miRNA supposed to regulate innate immune, inflammatory response and antiviral pathway negatively. In this review, we focus on the recent progress in functional role of miR-146a in innate immune, inflammatory response, virus infection and human diseases. Together, these findings indicate that manipulation of miR-146a expression may represent a potential new therapy for several human diseases. Potential use of miR-146a as a biomarker for disease diagnosis, prevention and treatment is also discussed.
Li
L
L
Department of Pharmacology, School of Pharmaceutical Science, Central South University, Changsha, Hunan, China.
Chen
X-P
XP
Li
Y-J
YJ
D014408:Biomarkers, Tumor / Q000235:genetics; D006801:Humans; D007154:Immune System Diseases / Q000235:genetics*; D035683:MicroRNAs / Q000276:immunology*
D014408:Biomarkers, Tumor; D035683:MicroRNAs