Variants in the adiponectin gene and serum adiponectin: the Coronary Artery Development in Young Adults (CARDIA) Study.
Circulating adiponectin is involved in the atherosclerotic process and has been associated with cardiovascular disease as well as obesity, insulin resistance, metabolic syndrome, and type 2 diabetes. The adiponectin gene (ADIPOQ) encodes the circulating protein adiponectin and affects its expression. Only a small proportion of all known ADIPOQ polymorphisms have been investigated in relation to circulating adiponectin concentrations. Using data from 3,355 African-American and white men and women aged 33-45 at the year 15 examination from the Coronary Artery Development in Young Adults (CARDIA) Study the association between 10 single-nucleotide polymorphisms (SNPs) within ADIPOQ and serum adiponectin was examined using linear regression. SNPs were chosen based on a tagSNP approach. Models were stratified by self-reported race to control for population stratification, and Bonferroni corrected for multiple comparisons. ADIPOQ SNPs rs17300539 (P < 0.0001), rs182052 (P = 0.0013), rs822393 (P = 0.0005), rs9882205 (P = 0.0001), and rs3774261 (P = 0.0001) were strongly associated with serum adiponectin concentrations in whites. In general, there was a dose-response relationship of adjusted mean adiponectin concentrations across genotypes. Only one SNP, rs17300539 was marginally associated with serum adiponectin concentrations (P = 0.0087) in African Americans. Significant interactions were found between waist and rs182052 (P = 0.0029) and between rs9882505 and smoking (P = 0.001) in whites. Many ADIPOQ SNPs have not yet been examined, and additional studies are needed to determine whether these may be functional variants.
Wassel
Christina L
CL
Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California, USA. cwassel@ucsd.edu
Pankow
James S
JS
Jacobs
David R
DR
Steffes
Michael W
MW
Li
Na
N
Schreiner
Pamela J
PJ
D052242:Adiponectin / Q000097:blood / Q000235:genetics*; D000328:Adult; D001741:Black or African American / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012907:Smoking / Q000208:ethnology / Q000235:genetics*; D055105:Waist Circumference / Q000208:ethnology / Q000235:genetics; D044465:White People / Q000235:genetics*
D052242:Adiponectin
Am J Epidemiol. 2007 Jan 15;165(2):164-74
17101706
Thromb Haemost. 2007 Mar;97(3):451-7
17334513
BMC Genet. 2005 Dec 30;6 Suppl 1:S80
16451695
Gene. 2004 Nov 10;342(1):25-8
15527961
Am J Hum Genet. 2004 Jan;74(1):106-20
14681826
J Clin Endocrinol Metab. 2006 Mar;91(3):1001-8
16352688
Hum Mol Genet. 2002 Oct 1;11(21):2607-14
12354786
J Clin Invest. 2006 Jul;116(7):1784-92
16823476
Clin Appl Thromb Hemost. 2006 Apr;12(2):163-8
16708117
Diabetes. 2005 May;54(5):1607-10
15855354
Clin Endocrinol (Oxf). 2006 Feb;64(2):196-202
16430720
J Clin Endocrinol Metab. 2007 Feb;92(2):571-6
17119002
Diabetes. 2007 May;56(5):1198-209
17303804
J Endocrinol. 2007 Apr;193(1):137-45
17400811
Circulation. 2006 Aug 15;114(7):623-9
16894037
Obesity (Silver Spring). 2006 Feb;14(2):319-26
16571859
JAMA. 2004 Apr 14;291(14):1730-7
15082700
J Cardiol. 2009 Apr;53(2):219-25
19304126
Metabolism. 2006 Dec;55(12):1653-7
17142139
Atherosclerosis. 2009 Aug;205(2):632-6
19217624
Eur Heart J. 2008 Mar;29(5):649-57
18263867
J Mol Med (Berl). 2005 Sep;83(9):711-9
15877215
Am J Clin Nutr. 2005 Oct;82(4):760-7
16210704
Clin Chim Acta. 2004 Jun;344(1-2):1-12
15149866
Diabetes. 2006 Feb;55(2):375-84
16443770
Bioinformatics. 2005 Jan 15;21(2):263-5
15297300
J Biol Chem. 2003 Nov 7;278(45):45021-6
12944390
Metab Syndr Relat Disord. 2008 Jun;6(2):87-102
18510434
Am J Physiol Heart Circ Physiol. 2007 Apr;292(4):H1655-63
17142348
Control Clin Trials. 1987 Dec;8(4 Suppl):68S-73S
3440391
J Am Coll Cardiol. 2006 Oct 3;48(7):1369-77
17010797
J Clin Endocrinol Metab. 2006 Dec;91(12):5044-50
16984981