Immune promotion of epithelial-mesenchymal transition and generation of breast cancer stem cells.
Elements of the immune system act as intimate regulators of cancer progression, inhibiting early stages of tumor growth, through immunosurveillance while facilitating later stages of tumor progression. Recent findings have revealed that activated CD8 T cells can stimulate mammary epithelial tumor cells to undergo epithelial-mesenchymal transition (EMT) and to acquire the greatly increased tumorigenic capability and chemotherapeutic resistance of breast cancer stem cells (BCSC). These studies provide a window to understanding how BCSC arise and are maintained within tumors, and how to best target these processes for therapeutic benefit.
Reiman
Jennifer M
JM
Department of Immunology, Mayo Clinic, Rochester, Minnesota, USA.
Knutson
Keith L
KL
Radisky
Derek C
DC
D000818:Animals; D001943:Breast Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000628:therapy*; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology; D018450:Disease Progression; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007107:Immune System; D008648:Mesoderm / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000166:cytology / Q000378:metabolism*; D051381:Rats
Cancer Cell. 2009 Aug 4;16(2):91-102
19647220
Cell. 2004 Mar 19;116(6):769-78
15035980
Cell. 2009 Aug 21;138(4):645-659
19682730
Am J Pathol. 2007 Sep;171(3):861-71
17675578
Dev Cell. 2008 Jun;14(6):818-29
18539112
Semin Cancer Biol. 2007 Aug;17(4):275-87
17662614
J Clin Oncol. 2008 Jun 10;26(17):2813-20
18539959
Nature. 1994 Feb 17;367(6464):645-8
7509044
Mech Dev. 2003 Nov;120(11):1351-83
14623443
Carcinogenesis. 2008 Oct;29(10):1930-7
18667445
Cancer Res. 2009 Apr 1;69(7):2887-95
19276366
J Am Soc Nephrol. 2004 Feb;15(2):390-7
14747385
Cell. 2008 May 16;133(4):704-15
18485877
Cancer Cell. 2005 May;7(5):411-23
15894262
J Clin Invest. 2009 Jun;119(6):1438-49
19487820
Eur J Immunol. 2008 Mar;38(3):640-6
18266270
J Mammary Gland Biol Neoplasia. 2009 Mar;14(1):29-43
19242781
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3983-8
12629218
Mol Biol Cell. 2003 May;14(5):1790-800
12802055
Mol Cancer Res. 2006 Apr;4(4):221-33
16603636
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13820-5
19666588
J Cell Physiol. 2007 Nov;213(2):374-83
17680632
J Immunol. 2006 Aug 1;177(3):1526-33
16849459
Eur J Immunol. 2007 Mar;37(3):675-85
17304628
PLoS One. 2008 Aug 06;3(8):e2888
18682804
Cancer Cell. 2006 Sep;10(3):227-39
16959614
Annu Rev Immunol. 2004;22:329-60
15032581