title: Highly effective and diastereoselective synthesis of axially chiral bis-sulfoxide ligands via oxidative aryl coupling.
abstract: A series of axially chiral bis-sulfoxide ligands have been efficiently synthesized via oxidative coupling with high diastereoselectivities. The axial chirality is well controlled by the tert-butylsulfinyl or the p-tolylsulfinyl group. These axially chiral bis-sulfoxides proved to be remarkably efficient ligands for the rhodium-catalyzed asymmetric 1,4-addition of arylboronic acids to 2-cyclohexenone with 99% ee.
authors.affiliation: State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, China.
authors.forename: Qing-An
authors.initials: QA
authors.lastname: Chen
authors.forename: Xiang
authors.initials: X
authors.lastname: Dong
authors.forename: Mu-Wang
authors.initials: MW
authors.lastname: Chen
authors.forename: Duo-Sheng
authors.initials: DS
authors.lastname: Wang
authors.forename: Yong-Gui
authors.initials: YG
authors.lastname: Zhou
authors.forename: Yu-Xue
authors.initials: YX
authors.lastname: Li