Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis.
Spermatogenesis is a highly regulated process of germ cell proliferation and differentiation, starting from spermatogonia to spermatocytes and giving rise to spermatids, the future spermatozoa. In addition to endocrine regulation, testicular cell-cell interactions are essential for spermatogenesis. This precise control is mediated through paracrine/autocrine pathways, direct intercellular contacts and through intercellular communication channels, consisting of gap junctions and their constitutive proteins, the connexins. Gap junctions are localized between adjacent Leydig cells, between Sertoli cells and between Sertoli cells and specific germ cells. This review focuses on the distribution of connexins within the seminiferous epithelium, their participation in gap junction channel formation, the control of their expression and the physiological relevance of these junctions in both the Sertoli-Sertoli cell functional synchronization and the Sertoli-germ cell dialogue. In this review, we also discuss the potential implication of disrupted connexin in testis cancer, since impaired expression of connexin has been described as a typical feature of tumoral proliferation.
Pointis
Georges
G
INSERM U 895, Team 5 Physiopathology of Germ Cell Control: Genomic and Non-genomic Mechanisms, Bâtiment Universitaire ARCHIMED, C3M, 151 route Saint-Antoine de Ginestière, BP 2 3194, 06204 Nice Cedex 3, France.
Gilleron
Jérome
J
Carette
Diane
D
Segretain
Dominique
D
D000818:Animals; D002450:Cell Communication / Q000502:physiology; D017630:Connexins / Q000235:genetics / Q000502:physiology*; D017629:Gap Junctions / Q000502:physiology*; D006801:Humans; D008297:Male; D012670:Seminiferous Epithelium / Q000166:cytology / Q000502:physiology; D012708:Sertoli Cells / Q000166:cytology / Q000502:physiology; D013091:Spermatogenesis / Q000502:physiology*; D013094:Spermatozoa / Q000502:physiology
D017630:Connexins
Am J Physiol Cell Physiol. 2002 Sep;283(3):C960-70
12176752
Biol Reprod. 2007 Jan;76(1):2-8
16971556
Toxicol Sci. 2003 Feb;71(2):146-53
12563100
J Coll Physicians Surg Pak. 2006 Jan;16(1):55-60
16441992
Biol Reprod. 2002 Sep;67(3):945-52
12193406
Biol Reprod. 2003 Jul;69(1):37-47
12606389
J Cell Sci. 2004 Sep 15;117(Pt 20):4665-72
15331631
J Toxicol Environ Health A. 2002 Mar;65(5-6):447-59
11936224
Science. 1995 Mar 24;267(5205):1831-4
7892609
J Cell Physiol. 2006 Oct;209(1):153-61
16823880
Toxicol Sci. 2004 Sep;81(1):179-89
15159524
Neuron Glia Biol. 2007 Aug;3(3):199-208
18634611
Int J Oncol. 2003 Dec;23(6):1615-35
14612934
Toxicol In Vitro. 2008 Oct;22(7):1719-25
18706992
Neoplasia. 2006 Jun;8(6):499-509
16820096
J Androl. 1995 Sep-Oct;16(5):400-9
8575979
Traffic. 2009 Sep;10(9):1272-85
19548984
Reprod Fertil Dev. 1995;7(3):603-11
8606973
Indian J Physiol Pharmacol. 2003 Apr;47(2):147-56
15255617
J Cell Sci. 2008 Dec 15;121(Pt 24):4069-78
19033388
Biochim Biophys Acta. 2005 Dec 20;1719(1-2):125-45
16359943
Curr Biol. 1998 Feb 26;8(5):295-8
9501069
J Biol Chem. 1992 Jan 25;267(3):2057-64
1370487
Reprod Toxicol. 2004 May;18(3):413-21
15082077
Endokrynol Pol. 2008 Mar-Apr;59(2):112-8
18465685
J Neurosci. 2003 Jun 1;23(11):4549-59
12805295
Histochem Cell Biol. 1999 Sep;112(3):215-20
10502068
Cell Tissue Res. 1999 Oct;298(1):113-21
10555545
FEBS Lett. 1999 Jun 25;453(3):243-8
10405153
Development. 2006 Sep;133(17):3451-60
16887824
J Membr Biol. 2007 Aug;218(1-3):73-7
17657524
Cardiovasc Res. 2004 May 1;62(2):378-87
15094357
J Membr Biol. 1996 Feb;149(3):179-87
8801350
Dev Biol. 2002 Nov 15;251(2):206-20
12435353
Biol Reprod. 2001 Sep;65(3):829-38
11514348
Cell Biol Int Rep. 1986 Aug;10(8):631-9
3019577
J Endocrinol. 2003 May;177(2):327-35
12740021
Apoptosis. 2006 Jul;11(7):1215-29
16699959
Dev Biol. 2001 Mar 15;231(2):334-47
11237463
Curr Biol. 2000 Sep 21;10(18):1083-91
10996788
Front Biosci. 1998 Feb 15;3:d208-36
9458335
Physiol Rev. 2003 Oct;83(4):1359-400
14506308
Novartis Found Symp. 1999;219:76-88; discussion 88-96
10207899
J Biol Chem. 2002 Oct 11;277(41):38272-83
12154091
Front Biosci. 2007 Jan 01;12:1552-62
17127402
Prog Biophys Mol Biol. 2007 May-Jun;94(1-2):245-64
17462721
Curr Biol. 1998 Feb 26;8(5):299-302
9501070
Am J Physiol Cell Physiol. 2006 Mar;290(3):C733-40
16236818
Microsc Res Tech. 2009 Nov;72(11):845-55
19455679
Biol Reprod. 2004 Aug;71(2):392-404
15056568
J Membr Biol. 2007 Jun;217(1-3):13-9
17568974
Biol Reprod. 2000 Dec;63(6):1661-8
11090433
Sci STKE. 2005 Jul 05;2005(291):pe33
15998870
Biochim Biophys Acta. 2008 Jan;1778(1):56-67
17949680
J Biol Chem. 1992 Aug 25;267(24):17225-33
1512260
Acta Histochem Cytochem. 2007 Jul 3;40(3):69-75
17653298
Anat Rec. 2001 Nov 1;264(3):237-46
11596006
J Cell Physiol. 1999 Nov;181(2):258-72
10497305
J Membr Biol. 1994 Apr;139(2):81-96
8064845
Development. 2002 May;129(10):2529-39
11973283
FEBS Lett. 2003 Apr 10;540(1-3):151-6
12681499
Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13644-9
14597722
Circulation. 2001 Mar 20;103(11):1591-8
11257090
Cell Commun Adhes. 2003 Jul-Dec;10(4-6):173-80
14681012
Am J Pathol. 2007 Jul;171(1):19-31
17591950
Circ Res. 2005 Sep 30;97(7):655-62
16123333
Fertil Steril. 2008 Jul;90(1):141-7
17825302
J Membr Biol. 1996 Feb;149(3):169-77
8801349
J Mol Histol. 2005 Feb;36(1-2):97-110
15704004
APMIS. 2004 Feb;112(2):79-88
15056223
J Cell Physiol. 2004 Jul;200(1):146-54
15137067
Biol Reprod. 1999 May;60(5):1263-70
10208994
Endocr Rev. 2004 Oct;25(5):747-806
15466940
Am J Physiol. 1994 Aug;267(2 Pt 1):C570-80
7521131
Genomics. 2004 Apr;83(4):706-16
15028292
J Invest Dermatol. 2007 Dec;127(12):2713-25
18007692
Physiol Rev. 1972 Jan;52(1):198-236
4621362
Cell. 1997 Dec 12;91(6):833-43
9413992
J Biol Chem. 1999 May 21;274(21):14716-23
10329667
Biol Reprod. 1996 Jun;54(6):1300-10
8724358
Am J Physiol. 1994 Aug;267(2 Pt 1):C563-9
8074190
Prog Biophys Mol Biol. 2007 May-Jun;94(1-2):29-65
17507078
Bioessays. 1996 Sep;18(9):709-18
8831287
Biol Reprod. 2007 May;76(5):804-12
17229929
Trends Endocrinol Metab. 2005 Sep;16(7):300-6
16054834
J Cell Biol. 1998 Mar 23;140(6):1453-61
9508777
J Cell Biol. 1998 Nov 2;143(3):815-25
9813099
Dev Biol. 1996 Apr 10;175(1):50-6
8608868
J Cell Biol. 1989 Dec;109(6 Pt 2):3391-401
2557354
Dev Biol. 2008 Mar 1;315(1):173-88
18234180
Biol Reprod. 2008 Mar;78(3):445-54
18057314
J Pathol. 2002 Aug;197(5):647-53
12210085
Biol Chem. 2002 May;383(5):725-37
12108537
Histochem Cell Biol. 2008 Sep;130(3):537-48
18542985
Eur J Histochem. 2007 Oct-Dec;51(4):261-8
18162455
Soc Reprod Fertil Suppl. 2007;63:11-23
17566257
Cancer Res. 1998 Nov 15;58(22):5089-96
9823317
Cell Tissue Res. 1998 Nov;294(2):279-87
9799444
Nature. 1997 Feb 6;385(6616):525-9
9020357
Biol Reprod. 2005 May;72(5):1232-40
15647452
BMC Dev Biol. 2007 Apr 04;7:26
17408477
Carcinogenesis. 2001 Sep;22(9):1537-42
11532877
Exp Cell Res. 2001 Nov 1;270(2):235-47
11640887
Glia. 2006 Nov 15;54(7):758-73
17006904
Antioxid Redox Signal. 2009 Feb;11(2):323-38
18834328
Biochim Biophys Acta. 2005 Dec 20;1719(1-2):36-58
16216217
Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9565-70
8790370
J Pathol. 2004 Feb;202(2):241-6
14743507
Lab Invest. 2003 Mar;83(3):449-56
12649345
J Cell Sci. 1992 Sep;103 ( Pt 1):81-96
1331136
Carcinogenesis. 2003 Aug;24(8):1415-23
12807735
Apoptosis. 2005 May;10(3):459-69
15909108
J Histochem Cytochem. 2000 Jun;48(6):793-805
10820153
Mol Carcinog. 2003 Dec;38(4):179-87
14639657
Aquat Toxicol. 2008 Jan 20;86(1):38-48
18006156
Biol Reprod. 2008 Jan;78(1):101-14
17928626
Dev Genet. 1999;24(1-2):43-56
10079510
Int J Cancer. 2007 Aug 1;121(3):536-46
17372902
Curr Drug Targets. 2002 Dec;3(6):465-82
12448698
Biochim Biophys Acta. 2005 Jun 10;1711(2):126-41
15955298
Biol Reprod. 2003 Apr;68(4):1232-40
12606457
J Androl. 2005 Jan-Feb;26(1):75-84
15611570
Reproduction. 2003 Jun;125(6):769-84
12773099
Biochem Biophys Res Commun. 2003 Aug 8;307(4):782-90
12878178
Physiol Rev. 2002 Oct;82(4):825-74
12270945
Cell Mol Life Sci. 2006 May;63(10):1125-40
16568237
Biol Reprod. 2000 Mar;62(3):748-54
10684819
Curr Med Chem. 2007;14(21):2288-303
17896977
Zygote. 2006 Nov;14(4):349-57
17266793
Anat Rec. 2001 Sep 1;264(1):13-24
11505367
Biochim Biophys Acta. 2009 Jan;1795(1):53-61
18801412
J Endocrinol. 2000 Aug;166(2):447-53
10927634
Int J Biochem Cell Biol. 2009 Jun;41(6):1381-90
19136074