Fish oil containing intravenous lipid emulsions in parenteral nutrition-associated cholestatic liver disease.
OBJECTIVE
Lipid emulsions containing fish oils have been proposed to improve parenteral nutrition associated cholestasis (PNAC), a very serious complication of prolonged parenteral nutrition occurring particularly in infants and children with intestinal failure. Here, we summarize current data.


RESULTS
The cause of PNAC is multifactorial. Prevention is possible by appropriate management, surgical procedures, infection prevention, and optimal parenteral nutrition management. Plausible hypotheses and experimental data support potential benefits of fish oils for treatment and prevention of PNAC. Improvement of PNAC over weeks and months has been reported in observational case studies in part of the children who received parenteral lipids with fish oil, but similar improvements also occurred by withholding or reducing standard lipid emulsions. No controlled trials are available that would allow final conclusions on efficacy and safety of fish oil-based emulsions in PNAC. Concerns exist regarding possible untoward effects and an inadequate supply of n-6 fatty acids with parenteral fish oil only. First data from controlled trials with mixed lipid emulsions containing partly fish oil suggest safety in infants and children and some possible benefits for liver function.


CONCLUSIONS
The observed improvement of PNAC on parenteral lipids with fish oil deserves further exploration. No controlled trials are available, nutritional adequacy and safety of 100% fish oil emulsions are not adequately documented, and currently their use cannot be considered standard care. First data on mixed lipid emulsions with some fish oil are encouraging, and their effects in PNAC should also be explored.
Koletzko
Berthold
B
Division of Metabolic and Nutritional Medicine, Dr von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany. office.koletzko@med.uni-muenchen.de
Goulet
Olivier
O
D002648:Child; D002780:Cholestasis, Intrahepatic / Q000209:etiology / Q000517:prevention & control*; D005217:Fat Emulsions, Intravenous / Q000737:chemistry*; D043371:Fatty Acids, Omega-6 / Q000627:therapeutic use; D005395:Fish Oils / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D007410:Intestinal Diseases / Q000628:therapy*; D010288:Parenteral Nutrition / Q000009:adverse effects*
D005217:Fat Emulsions, Intravenous; D043371:Fatty Acids, Omega-6; D005395:Fish Oils