Primary diffuse leptomeningeal gliomatosis: report of a case presenting with chronic meningitis.
Neoplastic meningitis occurs in approximately 5% of patients with cancer. Primary diffuse leptomeningeal gliomatosis is a rare condition whereby a glioma arises from heterotopic cell nests in the leptomeninges. We report here a case presenting with clinical features similar to those of chronic infectious meningitis without positive cerebrospinal fluid cytology. Neurological signs in our patient deteriorated progressively without responding to antitubercular, antiviral, or antibiotic therapy. Leptomeningeal biopsy sampling revealed the condition to be primary diffuse leptomeningeal gliomatosis.
Kim
Sung-Hun
SH
Department of Neurology, Seoul National University College of Medicine, Seoul, Korea.
Jun
Dong-Chul
DC
Park
Jin Se
JS
Heo
Jae-Hyeok
JH
Kim
Sung-Min
SM
Kim
Juhan
J
Paek
Sun Ha
SH
Kim
Manho
M
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