Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes.
The synthesis of three pairs of orthogonally labelled fluorinated Cu bis(thiosemicarbazonato) complexes is presented. These are the first examples of (18)F-labelled Cu(II)-complexes designed to serve as new hypoxia selective PET tracers and as mechanistic probes to study the mode of action of this class of markers. In vitro evaluation revealed that the fluorinated Cu-complex derived from amide coupling is suitable for in vivo work.
Carroll
Laurence
L
University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK.
Bejot
Romain
R
Hueting
Rebekka
R
King
Robert
R
Bonnitcha
Paul
P
Bayly
Simon
S
Christlieb
Martin
M
Dilworth
Jonathan R
JR
Gee
Antony D
AD
Declerck
Jérôme
J
Gouverneur
Véronique
V
D015687:Cell Hypoxia; D002460:Cell Line; D003301:Copper Radioisotopes / Q000737:chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*; D013882:Thiosemicarbazones / Q000737:chemistry
D003301:Copper Radioisotopes; D005462:Fluorine Radioisotopes; D013882:Thiosemicarbazones