title: Computational fluid dynamics analysis of thrombosis potential in left ventricular assist device drainage cannulae.
abstract: Cannulation is necessary when blood is removed from the body, for example in hemodialysis, cardiopulmonary bypass, blood oxygenators, and ventricular assist devices. Artificial blood contacting surfaces are prone to thrombosis, especially in the presence of stagnant or recirculating flow. In this work, computational fluid dynamics was used to investigate the blood flow fields in three clinically available cannulae (Medtronic DLP 12, 16, and 24 F), used as drainage for pediatric circulatory support and to calculate parameters that may be indicative of thrombosis potential. The results show that using the 24 F cannula below flow rates of about 0.75 L/min produces hemodynamic conditions, which may increase the risk of blood clotting within the cannula. No reasons are indicated for not using the 12 or 16 F cannulae with flow rates between 0.25 and 3.0 L/min.
authors.affiliation: Department of Surgery, Artificial Organs Laboratory, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
authors.forename: Katharine H
authors.initials: KH
authors.lastname: Fraser
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
authors.forename: M Ertan
authors.initials: ME
authors.lastname: Taskin
authors.forename: Bartley P
authors.initials: BP
authors.lastname: Griffith
authors.forename: Zhongjun J
authors.initials: ZJ
authors.lastname: Wu
mesh_terms: D002315:Cardiopulmonary Bypass; D002404:Catheterization / Q000295:instrumentation*; D002648:Child; D004322:Drainage; D006352:Heart Ventricles / Q000503:physiopathology; D006353:Heart-Assist Devices; D006439:Hemodynamics; D006801:Humans; D012307:Risk Factors; D013927:Thrombosis / Q000628:therapy
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