Poly(amino acid)s micelle-mediated assembly of magnetite nanoparticles for ultra-sensitive long-term MR imaging of tumors.
Micelles composed of a novel weakly cationic poly(amino acid)s shell and clustered magnetite nanoparticles as a core were prepared and evaluated as a potent MR imaging contrast agent based on their superior physicochemical and magnetic properties and the effective MR imaging of cancer in vitro and in vivo.
Lee
Hyun Jin
HJ
Dept. of Chem. and Biomol. Eng. (BK21 Graduate Program), KAIST, Daejeon 305-701, Republic of Korea.
Jang
Kwang-Suk
KS
Jang
Sujeong
S
Kim
Jin Woong
JW
Yang
Hee-Man
HM
Jeong
Yong Yeon
YY
Kim
Jong-Duk
JD
D000596:Amino Acids / Q000737:chemistry; D002412:Cations / Q000737:chemistry; D003110:Colonic Neoplasms / Q000175:diagnosis*; D003287:Contrast Media / Q000737:chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry; D013499:Surface Properties
D000596:Amino Acids; D002412:Cations; D003287:Contrast Media; D008823:Micelles; D011108:Polymers