title: Phloroglucinols from the argentine ferns Elaphoglossum gayanum and E. piloselloides.
abstract: Five new prenylated phloroglucinols were isolated from the diethyl ether extracts of the ferns Elaphoglossum gayanum and E. piloselloides. Their structures were established by analysis of their spectroscopic data (1D and 2D NMR, HRMS, and IR) and chemical derivatization. The two major compounds exhibited moderate molluscicidal activity against the snail Biomphalaria peregrina, a vector of the tropical disease schistosomiasis, with LD(50) 7.2 microg/mL (14.4 microM) and 11.7 microg/mL (22.2 microM).
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
authors.forename: Cecilia
authors.initials: C
authors.lastname: Socolsky
authors.forename: Susana A
authors.initials: SA
authors.lastname: Borkosky
authors.forename: Marcela
authors.initials: M
authors.lastname: Hernández de Terán
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Asakawa
authors.forename: Alicia
authors.initials: A
authors.lastname: Bardón
mesh_terms: D000818:Animals; D001118:Argentina; D029624:Ferns / Q000737:chemistry*; D015394:Molecular Structure; D008975:Molluscacides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012552:Schistosomiasis / Q000188:drug therapy; D012908:Snails / Q000187:drug effects*
chemical_list: D008975:Molluscacides; D010696:Phloroglucinol