title: Polycationic nanoparticles as nonviral vectors employed for gene therapy in vivo.
abstract: Currently, polycationic nanoparticles (polycation) as nonviral vectors are promising to overcome the defects of traditional viral vectors. This review focuses on the recent progress and challenges to improve the transfection efficacy and circulation time of polyplexes (complexes between polycation and pDNA or oligonucleotides such as siRNA) in vivo.
authors.affiliation: Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, PR China. liangxj@nanoctr.cn
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Xing
authors.forename: Liandong
authors.initials: L
authors.lastname: Deng
authors.forename: Shutao
authors.initials: S
authors.lastname: Guo
authors.forename: Anjie
authors.initials: A
authors.lastname: Dong
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Liang
mesh_terms: D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D053758:Nanoparticles / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry / Q000494:pharmacology; D010957:Plasmids / Q000737:chemistry / Q000494:pharmacology; D011073:Polyamines / Q000737:chemistry* / Q000494:pharmacology; D000071228:Polyelectrolytes
chemical_list: D009841:Oligonucleotides; D011073:Polyamines; D000071228:Polyelectrolytes