How the sequence of a gene can tune its translation.
Sixty-one codons specify 20 amino acids, offering cells many options for encoding a polypeptide sequence. Two new studies (Cannarrozzi et al., 2010; Tuller et al., 2010) now foster the idea that patterns of codon usage can control ribosome speed, fine-tuning translation to increase the efficiency of protein synthesis.
Fredrick
Kurt
K
Department of Microbiology, Ohio State Biochemistry Program, and Center for RNA Biology, The Ohio State University, Columbus, OH 43210, USA. fredrick.5@osu.edu
Ibba
Michael
M
D001483:Base Sequence; D003062:Codon; D014176:Protein Biosynthesis; D012270:Ribosomes / Q000502:physiology*
D003062:Codon
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