Comprehensive imaging of residual/ recurrent nasopharyngeal carcinoma using whole-body MRI at 3 T compared with FDG-PET-CT.
OBJECTIVE
To prospectively compare the diagnostic potential of 3-T wholebody magnetic resonance imaging (WB-MRI) and integrated fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) (FDG-PET-CT), and their combined interpretation for the detection of residual/recurrent nasopharyngeal carcinoma (NPC).


METHODS
We enrolled 179 NPC patients at high risk of residual disease or with suspected recurrence. WB-MRI and FDG-PET-CT were obtained with an interval of <10 days.


RESULTS
Fifty-five (30.7%) patients were found to have residual/recurrent tumours. In a patient-based analysis, the sensitivity, specificity and diagnostic capability of WB-MRI were similar to those of FDG-PET-CT (90.9% vs. 87.3%, P=0.69; 91.1% vs. 90.3%, P>0.99; 0.929 vs. 0.924, P=0.83, respectively). Combined interpretation of WB-MRI with FDGPET-CT increased the sensitivity to 94.5%. A slight improvement in the diagnostic capability was obtained using a combined interpretation of WB-MRI and FDG-PET-CT over WB-MRI alone (0.952 vs. 0.929, P=0.22) and FDG-PET-CT alone (0.952 vs. 0.924, P=0.11).


CONCLUSIONS
Three-Tesla WB-MRI achieved a similar diagnostic capability to FDGPET-CT for the detection of residual/recurrent NPC. Both techniques have different advantages, and their combined interpretation can yield a slightly higher diagnostic capability. In clinical practice, 3-T WB-MRI can offer an accurate and comprehensive assessment of residual/recurrent NPC.
Ng
Shu-Hang
SH
Molecular Imaging Center, Chang Gung University, Gueishan, Taiwan. shng6@ms25.hinet.net
Chan
Sheng-Chieh
SC
Yen
Tzu-Chen
TC
Liao
Chun-Ta
CT
Chang
Joseph Tung-Chieh
JT
Ko
Sheung-Fat
SF
Wang
Hung-Ming
HM
Lin
Chin-Yu
CY
Chang
Kai-Ping
KP
Lin
Yu-Chun
YC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D018365:Neoplasm, Residual / Q000175:diagnosis; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods*; D055815:Young Adult
D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
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