title: [Antisense oligonucleotides as potential drugs for prophylaxis of prion infections].
abstract: Prion mRNA translation inhibition by antisense oligodeoxynucleotides (asODN) incorporated into immunoliposomes was investigated. It was shown that asODN complementary to cap region, start-codon region and a part of open reading frame can decrease the prion expression by 80% in L1210 cell line and by 60% in prion-replicating organs of laboratory rats. These results give grounds for further research asODN to be used as a means of prevention and treatment of prion infections.
authors.forename: V V
authors.initials: VV
authors.lastname: Stadnyk
authors.forename: L A
authors.initials: LA
authors.lastname: Iziumova
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Rzhepets'kyĭ
authors.forename: Kh Ia
authors.initials: KhIa
authors.lastname: Maĭor
authors.forename: P I
authors.initials: PI
authors.lastname: Verbyts'kyĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Vlizlo
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D045744:Cell Line, Tumor; D018387:Codon, Initiator / Q000235:genetics; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D007939:Leukemia L1210; D008081:Liposomes; D051379:Mice; D020319:Oligodeoxyribonucleotides, Antisense / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D018621:PrPC Proteins / Q000096:biosynthesis* / Q000235:genetics; D017096:Prion Diseases / Q000517:prevention & control*; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000378:metabolism
chemical_list: D018387:Codon, Initiator; D008081:Liposomes; D020319:Oligodeoxyribonucleotides, Antisense; D018621:PrPC Proteins