Pulmonary non-Hodgkin's lymphoma developed during long-term methotrexate therapy for rheumatoid arthritis.
Methotrexate is effective in treating rheumatoid arthritis (RA). Some reports have discussed the possible association between methotrexate and lymphoma. Here, we report a case of pulmonary non-Hodgkin's lymphoma (NHL) developed after 11 years' methotrexate therapy for RA. Biopsy of the pulmonary mass demonstrated a diffuse large B-cell lymphoma. After withdrawal of methotrexate without any other intervention for 4 weeks, a significant reduction in the size of the lymphoma was observed. The causative relationship between methotrexate and pulmonary lymphoma is suggested by the persistent remission after stopping methotrexate therapy.
Wang
Huiying
H
Department of Respiratory Medicine, The Second Affiliated Hospital of Zhejiang University Medical School, Respiratory Institute of Zhejiang University, 88 Jiefang Road, 310009 Hangzhou, Zhejiang Province, People's Republic of China. w_huiying@yahoo.com
Wu
Dandan
D
Xiang
Hua
H
Chen
Aifeng
A
Liu
Jin
J
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced* / Q000473:pathology; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use
D008727:Methotrexate
Ann Rheum Dis. 2005 Jul;64(7):1098-9
15958773
Joint Bone Spine. 2006 Mar;73(2):218-9
16495108
Am J Hematol. 2007 Dec;82(12):1106-9
17654684
Clin Endocrinol (Oxf). 2006 Jun;64(6):716-7
16712679
Clin Nucl Med. 2006 May;31(5):272-4
16622335
J Clin Oncol. 1996 Jun;14(6):1943-9
8656264
J Rheumatol. 2001 Dec;28(12):2573-5
11764198
J Natl Cancer Inst. 2004 Nov 17;96(22):1691-702
15547182
Chest. 2003 Jun;123(6):2150-3
12796204