Host responses to Candida albicans: Th17 cells and mucosal candidiasis.
Candida albicans causes mucosal and disseminated candidiasis, which represent serious problems for the rapidly expanding immunocompromised population. Until recently, Th1-mediated immunity was thought to confer the primary protection, particularly for oral candidiasis. However, emerging data indicate that the newly-defined Th17 compartment appears to play the predominant role in mucosal candidiasis.
Conti
Heather R
HR
University at Buffalo, SUNY, Department of Oral Biology, Buffalo, NY, USA.
Gaffen
Sarah L
SL
D056704:Adaptive Immunity; D000818:Animals; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000276:immunology* / Q000378:metabolism; D002460:Cell Line; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D020381:Interleukin-17 / Q000378:metabolism*; D053759:Interleukin-23 / Q000378:metabolism; D007378:Interleukins / Q000378:metabolism; D023421:Models, Animal; D009092:Mucous Membrane / Q000276:immunology* / Q000378:metabolism / Q000382:microbiology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D000097043:Interleukin-22
D020381:Interleukin-17; D053759:Interleukin-23; D007378:Interleukins; D000097043:Interleukin-22
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