title: Efficacy of anakinra treatment in a patient with colchicine-resistant familial Mediterranean fever.
abstract: Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by self-limited recurrent attacks of fever and serositis. The serious complication of FMF is AA-type amyloidosis, which can result in end-stage renal disease. Although colchicine is effective in the majority of patients, there is no established treatment for those who are resistant or intolerant to colchicine. We herein report the efficacy of anakinra in a 52-year-old Turkish patient with FMF, secondary amyloidosis and renal transplant, who was resistant to colchicine treatment.
authors.affiliation: Department of Internal Medicine, Istanbul School of Medicine, Istanbul University, Capa, Istanbul, Turkey. nalpay@istanbul.edu.tr
authors.forename: Nilüfer
authors.initials: N
authors.lastname: Alpay
authors.forename: Abdullah
authors.initials: A
authors.lastname: Sumnu
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Calışkan
authors.forename: Halil
authors.initials: H
authors.lastname: Yazıcı
authors.forename: Aydın
authors.initials: A
authors.lastname: Türkmen
authors.forename: Ahmet
authors.initials: A
authors.lastname: Gül
mesh_terms: D000686:Amyloidosis / Q000209:etiology / Q000628:therapy; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003078:Colchicine / Q000627:therapeutic use*; D004351:Drug Resistance; D010505:Familial Mediterranean Fever / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation; D008875:Middle Aged; D017211:Treatment Failure
chemical_list: D000893:Anti-Inflammatory Agents; D053590:Interleukin 1 Receptor Antagonist Protein; D003078:Colchicine
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