Mechanisms underlying the effects of ultralow doses of antibodies to granulocytic colony-stimulating factor on recovery of damaged pancreatic tissue in experimental diabetes mellitus.
Using the model of alloxan-induced diabetes mellitus on rats we demonstrated the effect of ultralow doses of antibodies to granulocytic colony-stimulating factor on recovery of the pancreas and normalization of blood glucose concentration. The preparation produced an antiinflammatory and antisclerotic effects associated with activation of stem cells and their determined homing into the pancreas.
Ermakova
N N
NN
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Tomsk.
Zhdanov
V V
VV
Dygai
A M
AM
Zyuz'kov
G N
GN
Stavrova
L A
LA
Gur'yantseva
L A
LA
Khrichkova
T Yu
TY
Udut
E V
EV
Vetoshkina
T V
TV
Fomina
T I
TI
Ermolaeva
L A
LA
Goldberg
E D
ED
D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000276:immunology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010179:Pancreas / Q000187:drug effects* / Q000473:pathology
D000906:Antibodies; D016179:Granulocyte Colony-Stimulating Factor