title: Regulatory mechanisms for apoptosis in placental tissue during normal pregnancy and gestosis-complicated pregnancy.
abstract: The localization of apoptosis and expression of proapoptotic and antiapoptotic factors by the placental tissue were compared during normal pregnancy and gestosis-complicated pregnancy. The degree of apoptosis did not differ in the third trimester of normal pregnancy and gestosis-complicated pregnancy. Increased expression of Fas, caspase-8, and caspase-3 in placental tissue during normal pregnancy was shown to contribute to the suppression of angiogenesis and growth of placental tissue. No differences were found in the expression of FasL (CD95L), caspase-2, caspase-9, and Mcl-1 by placental cells during normal pregnancy and gestosis-complicated pregnancy. Increased expression of TRAIL by trophoblast cells is a protective mechanism from apoptotic signals of maternal cytotoxic lymphocytes and NK cells during gestosis.
authors.affiliation: DO Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St Petersburg, Russia. corbie@hotmail.ru
authors.forename: D I
authors.initials: DI
authors.lastname: Sokolov
authors.forename: A V
authors.initials: AV
authors.lastname: Kolobov
authors.forename: M V
authors.initials: MV
authors.lastname: Lesnichija
authors.forename: I N
authors.initials: IN
authors.lastname: Kostiouchek
authors.forename: O I
authors.initials: OI
authors.lastname: Stepanova
authors.forename: I M
authors.initials: IM
authors.lastname: Kvetnoy
authors.forename: S A
authors.initials: SA
authors.lastname: Selkov
mesh_terms: D017209:Apoptosis / Q000502:physiology*; D015415:Biomarkers / Q000378:metabolism; D053143:Caspase 2 / Q000378:metabolism; D053453:Caspase 9 / Q000378:metabolism; D053222:Fas Ligand Protein / Q000378:metabolism; D005260:Female; D005865:Gestational Age; D006801:Humans; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D010920:Placenta / Q000473:pathology / Q000502:physiology; D011225:Pre-Eclampsia / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism
chemical_list: D015415:Biomarkers; D053222:Fas Ligand Protein; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D019253:Proto-Oncogene Proteins c-bcl-2; D053143:Caspase 2; D053453:Caspase 9