title: Serotonin-induced region-specific responses of the arcuate and ventromedial hypothalamic nuclei.
abstract: The arcuate nucleus (ARC) modulates both satiety and hunger signals at the lateral and medial sites, respectively, though these competing responses may be both mediated by serotonin (5-HT). We sought to determine region-specific effects of 5-HT on ARC neurons. Electrical activities in rat hypothalamic slices were simultaneously recorded with an extracellular multielectrode array. 5-HT effects on the ARC were region-specific: primary inhibition of medial ARC and stimulation of lateral ARC neurons. 5-HT primarily inhibited ventromedial nucleus neurons. These results suggest ARC region-specific responses to 5-HT consistent with the anatomical location of lateral ARC anorexigenic proopiomelanocortin neurons and medial ARC orexigenic neuropeptide Y neurons.
authors.affiliation: Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Torrance, California 90502, USA.
authors.forename: Yousheng
authors.initials: Y
authors.lastname: Jia
authors.forename: Mostafa
authors.initials: M
authors.lastname: El-Haddad
authors.forename: Alfred
authors.initials: A
authors.lastname: Gendy
authors.forename: Tri
authors.initials: T
authors.lastname: Nguyen
authors.forename: Michael G
authors.initials: MG
authors.lastname: Ross
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000187:drug effects / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D004347:Drug Interactions; D005277:Fenfluramine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D010879:Piperazines / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D016713:Ritanserin / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects / Q000502:physiology*
chemical_list: D002118:Calcium; D005277:Fenfluramine; D010879:Piperazines; D011725:Pyridines; D016713:Ritanserin; D012701:Serotonin; D012702:Serotonin Antagonists; D017367:Selective Serotonin Reuptake Inhibitors; C090413:N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide