title: Antinuclear antibody-negative systemic lupus erythematosus in a case with pregnancy.
abstract: We described a 30-year-old pregnant woman developing antinuclear antibodies (ANA)-negative systemic lupus erythematosus (SLE) accompanied with arthritis, malar rash, lymphopenia, autoimmune hemolytic anemia, pericardial and pleural effusion, proteinuria and seizures. All serum autoantibodies except anti-Ro antibody were negative. An artificially induced abortion was performed to prevent SLE deterioration. Steroid and cyclophosphamide therapy were effective for this patient. During the 2-year follow-up period, her ANA and other SLE-related autoantibodies in serum remained negative. This case suggests that ANA may not be required in the pathogenesis of SLE, even in the case with pregnancy, and ANA-negative SLE may also have a dangerous clinical course.
authors.affiliation: Department of Rheumatology and Immunology, West China Hospital of Sichuan University, 610041 Chengdu, Sichuan, China.
authors.forename: Qibing
authors.initials: Q
authors.lastname: Xie
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Nanping
authors.initials: N
authors.lastname: Yang
authors.forename: Geng
authors.initials: G
authors.lastname: Yin
mesh_terms: D000032:Abortion, Therapeutic; D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D008279:Magnetic Resonance Imaging; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D012720:Severity of Illness Index; D013256:Steroids / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000974:Antibodies, Antinuclear; D015415:Biomarkers; D007166:Immunosuppressive Agents; C035356:SS-A antibodies; D013256:Steroids
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