Evidence for a relationship between body mass and energy metabolism in the human brain.
Cerebral energy metabolism has been suggested to have an important function in body weight regulation. We therefore examined whether there is a relationship between body mass and adenosine triphosphate (ATP) metabolism in the human brain. On the basis of our earlier findings indicating a neuroprotective preferential energy supply of the brain, as compared with peripheral muscle on experimentally induced hypoglycemia, we examined whether this physiological response is preserved also in low-weight and obese participants. We included 45 healthy male subjects with a body mass index (BMI) ranging from 17 to 44 kg/m(2). Each participant underwent a hypoglycemic glucose-clamp intervention, and the ATP metabolism, that is, the content of high-energy phosphates phosphocreatine (PCr) and ATP, was measured repeatedly by (31)phosphor magnetic resonance spectroscopy ((31)P-MRS) in the cerebral cortex and skeletal muscle. Results show an inverse correlation between BMI and high-energy phosphate content in the brain (P<0.01), whereas there was no such relationship found between skeletal muscle and BMI. The hypoglycemic clamp intervention did not affect the ATP metabolism in both tissues. Our data show an inverse correlation between BMI and cerebral high-energy phosphate content in healthy humans, suggesting a close relationship between energetic supply of the brain and body weight regulation.
Schmoller
André
A
Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, Luebeck, Germany. andre.schmoller@uk-sh.de
Hass
Torben
T
Strugovshchikova
Olga
O
Melchert
Uwe H
UH
Scholand-Engler
Harald G
HG
Peters
Achim
A
Schweiger
Ulrich
U
Hohagen
Fritz
F
Oltmanns
Kerstin M
KM
D000255:Adenosine Triphosphate / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001835:Body Weight; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D015309:Glucose Clamp Technique; D006801:Humans; D007328:Insulin / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D009765:Obesity / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D055815:Young Adult
D001786:Blood Glucose; D007328:Insulin; D010710:Phosphates; D000255:Adenosine Triphosphate
MAGMA. 2001 May;12(2-3):141-52
11390270
Neurosci Biobehav Rev. 2004 Apr;28(2):143-80
15172762
Science. 2005 Jan 21;307(5708):375-9
15662002
Am J Physiol Regul Integr Comp Physiol. 2008 Jan;294(1):R12-6
17977922
Science. 1999 Jan 22;283(5401):496-7
9988650
Nature. 2007 Sep 13;449(7159):228-32
17728716
Harv Rev Psychiatry. 2003 Mar-Apr;11(2):51-63
12868506
Diabetes. 1988 Jun;37(6):760-2
3289996
J Clin Invest. 2008 Jun;118(6):2132-47
18451994
Magn Reson Med. 1999 Feb;41(2):400-6
10080290
Fertil Steril. 2009 Jul;92(1):271-6
18692843
Annu Rev Physiol. 2008;70:513-35
17988209
Magn Reson Med. 2001 Feb;45(2):226-32
11180430
Nature. 2005 Apr 21;434(7036):1026-31
15846348
Magn Reson Med. 1990 Jul;15(1):165-72
2165209
Nat Neurosci. 2006 Feb;9(2):227-33
16415870
Nat Neurosci. 2000 Aug;3(8):757-8
10903566
FEBS Lett. 2008 Jan 9;582(1):132-41
18061579
Nature. 2000 Apr 6;404(6778):661-71
10766253
Proc Natl Acad Sci U S A. 1983 May;80(9):2748-51
6573678
J Cereb Blood Flow Metab. 2001 Jan;21(1):85-91
11149672
N Engl J Med. 1970 Mar 19;282(12):668-75
4915800
J Magn Reson. 1997 Nov;129(1):35-43
9405214
Science. 2000 Sep 22;289(5487):2122-5
11000114
Am J Physiol. 1999 May;276(5):R1223-31
10233011
Nat Neurosci. 2005 May;8(5):561-5
15856063
Clin Endocrinol (Oxf). 2005 Feb;62(2):217-22
15670199
Prog Neurobiol. 2007 Feb;81(2):61-88
17270337
Diabetologia. 2004 Apr;47(4):648-51
15298341
PLoS Med. 2005 Sep;2(9):e233
16089501