Diagnosis of post-transplant lymphoproliferative disorder in solid organ transplant recipients - BCSH and BTS Guidelines.
A joint working group established by the Haemato-oncology subgroup of the British Committee for Standards in Haematology (BCSH) and the British Transplantation Society (BTS) has reviewed the available literature and made recommendations for the diagnosis and management of post-transplant lymphoproliferative disorder (PTLD) in adult recipients of solid organ transplants. This review details the risk factors predisposing to development, initial features and diagnosis. It is important that the risk of developing PTLD is considered when using post transplant immunosuppression and that the appropriate investigations are carried out when there are suspicions of the diagnosis. These must include tissue for histology and computed tomography scan to assess the extent of disease. These recommendations have been made primarily for adult patients, there have been some comments made with regard to paediatric practice.
Parker
Anne
A
The Beatson, West of Scotland Cancer Centre, Glasgow, UK. bcsh@b-s-h.org.uk
Bowles
Kristin
K
Bradley
J Andrew
JA
Emery
Vincent
V
Featherstone
Carrie
C
Gupte
Girish
G
Marcus
Robert
R
Parameshwar
Jayan
J
Ramsay
Alan
A
Newstead
Charles
C
D020031:Epstein-Barr Virus Infections / Q000150:complications; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D016377:Organ Transplantation / Q000009:adverse effects*; D011159:Population Surveillance / Q000379:methods; D011182:Postoperative Care / Q000379:methods; D011300:Preoperative Care / Q000379:methods; D012307:Risk Factors