Accuracy of bedside antigen tests in the diagnosis of new influenza A/H1N1v infection.
To evaluate the clinical reliability of two rapid influenza detection tests (RIDTs), we analyzed 107 specimens from patients with clinically suspected pandemic influenza A/H1N1v by these tests as well as by real-time PCR as a standard. Both RIDTs had a moderate sensitivity (28-32%), a high specificity (93-99%) and a negative predictive value of 80%. These results will impact on the clinical management and isolation precautions in patients with suspected infection. Although a positive RITD is mostly confirmatory, a negative result in the presence of high clinical likelihood of infection should be interpreted with caution and be re-evaluated by PCR.
Bellmann-Weiler
R
R
Department of Internal Medicine I, Clinical Immunology and Infectious Diseases, Medical University of Innsbruck, Innsbruck, Austria.
Beikircher
B
B
Kurz
K
K
Theurl
I
I
Weiss
G
G
D000956:Antigens, Viral / Q000032:analysis*; D001317:Austria; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology / Q000302:isolation & purification*; D007251:Influenza, Human / Q000175:diagnosis*; D019095:Point-of-Care Systems; D012680:Sensitivity and Specificity; D014773:Virology / Q000379:methods*
D000956:Antigens, Viral