title: Effect of prolactin on excretory function of the liver during the induction and relief of cholestasis in female rats.
abstract: The effect of hyperprolactinemia on bile excretion from the liver of female rats was shown to increase significantly during obstructive cholestasis. The observed changes were biphasic: initial increase in bilirubin release of into the bile was followed by its reduction. Under conditions of obstructive cholestasis, hyperprolactinemia had a negative effect on the recovery of bile flow rate during decompression of the duct (up to complete cessation of bile flow).
authors.affiliation: Laboratory of Endocrinology, Biological Faculty, M V Lomonosov Moscow State University, Russia. kywnarevans@pochta.ru
authors.forename: N S
authors.initials: NS
authors.lastname: Kushnareva
authors.forename: O V
authors.initials: OV
authors.lastname: Smirnova
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism; D002779:Cholestasis / Q000503:physiopathology*; D005260:Female; D006966:Hyperprolactinemia / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D011388:Prolactin / Q000494:pharmacology*; D051381:Rats
chemical_list: D011388:Prolactin; D001663:Bilirubin