[S100A8, S100A9 and S100A12 proteins in rheumatoid arthritis].
Although S100 proteins represent 40% of the neutrophil cytoplasmic proteins, their physiological and pathological functions are still unclear. S100A8, S100A9 and S100A12 protein concentrations are dramatically enhanced in synovial fluid and synovium of patients suffering from rheumatoid arthritis. Their expression seems to correlate with disease activity and joint damage. These proteins are likely involved in rheumatoid arthritis pathogenesis by enhancing extracellular matrix proteolysis, autoimmunity and inducing the pseudotumoral phenotype of the synoviocytes in rheumatoid arthritis. S100A8, S100A9 and S100A12 assessment will probably constitute a relevant tool for rheumatoid arthritis diagnosis and will improve inflammatory arthritides management.
Baillet
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Clinique universitaire de rhumatologie, CHU hôpital Sud, avenue de Kimberley, BP 338, 38434 Echirolles cedex, France. abaillet@chu-grenoble.fr
D001172:Arthritis, Rheumatoid / Q000097:blood / Q000175:diagnosis* / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D040501:Calgranulin A / Q000097:blood*; D040502:Calgranulin B / Q000097:blood*; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000276:immunology; D011237:Predictive Value of Tests; D009418:S100 Proteins / Q000097:blood*; D000067616:S100A12 Protein; D012680:Sensitivity and Specificity; D013582:Synovial Fluid / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology
D015415:Biomarkers; D040501:Calgranulin A; D040502:Calgranulin B; D009418:S100 Proteins; D000067616:S100A12 Protein; C090441:S100A12 protein, human