Coffee and caffeine ameliorate hyperglycemia, fatty liver, and inflammatory adipocytokine expression in spontaneously diabetic KK-Ay mice.
Epidemiological surveys have demonstrated that habitual coffee consumption reduces the risk of type 2 diabetes. The aim of this work was to study the antidiabetic effect of coffee and caffeine in spontaneously diabetic KK-A(y) mice. KK-A(y) mice were given regular drinking water (controls) or 2-fold diluted coffee for 5 weeks. Coffee ingestion ameliorated the development of hyperglycemia and improved insulin sensitivity. White adipose tissue mRNA levels of inflammatory cytokines (MCP-1, IL-6, and TNFalpha), adipose tissue MCP-1 concentration, and serum IL-6 concentration in the coffee group were lower than the control group. Moreover, coffee ingestion improved the fatty liver. Caffeine ingestion as drinking water also caused an amelioration of hyperglycemia and an improvement of fatty liver. These results suggest that coffee exerts a suppressive effect on hyperglycemia by improving insulin sensitivity, partly due to reducing inflammatory cytokine expression and improving fatty liver. Moreover, caffeine may be one of the effective antidiabetic compounds in coffee.
Yamauchi
Rie
R
Department of Applied Molecular Bioscience, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan.
Kobayashi
Misato
M
Matsuda
Yuji
Y
Ojika
Makoto
M
Shigeoka
Shigeru
S
Yamamoto
Yuko
Y
Tou
Yoshie
Y
Inoue
Takashi
T
Katagiri
Takao
T
Murai
Atsushi
A
Horio
Fumihiko
F
D054392:Adipokines / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002110:Caffeine / Q000494:pharmacology*; D003069:Coffee / Q000737:chemistry*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005234:Fatty Liver / Q000517:prevention & control*; D006943:Hyperglycemia / Q000517:prevention & control*; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics
D054392:Adipokines; D001786:Blood Glucose; D003069:Coffee; D012333:RNA, Messenger; D002110:Caffeine