Effect of prolactin on excretory function of the liver during the induction and relief of cholestasis in female rats.
The effect of hyperprolactinemia on bile excretion from the liver of female rats was shown to increase significantly during obstructive cholestasis. The observed changes were biphasic: initial increase in bilirubin release of into the bile was followed by its reduction. Under conditions of obstructive cholestasis, hyperprolactinemia had a negative effect on the recovery of bile flow rate during decompression of the duct (up to complete cessation of bile flow).
Kushnareva
N S
NS
Laboratory of Endocrinology, Biological Faculty, M V Lomonosov Moscow State University, Russia. kywnarevans@pochta.ru
Smirnova
O V
OV
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001663:Bilirubin / Q000378:metabolism; D002779:Cholestasis / Q000503:physiopathology*; D005260:Female; D006966:Hyperprolactinemia / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D011388:Prolactin / Q000494:pharmacology*; D051381:Rats
D011388:Prolactin; D001663:Bilirubin