title: Phospholipase D in brain function and Alzheimer's disease.
abstract: Alzheimer's disease is the most common neurodegenerative disorder. Although lipids are major constituents of brain, their role in Alzheimer's disease pathogenesis is poorly understood. Much attention has been given to cholesterol, but growing evidence suggests that other lipids, such as phospholipids, might play an important role in this disorder. In this review, we will summarize the evidence linking phospholipase D, a phosphatidic acid-synthesizing enzyme, to multiple aspects of normal brain function and to Alzheimer's disease. The role of phospholipase D in signaling mechanisms downstream of beta-amyloid as well as in the trafficking and processing of amyloid precursor protein will be emphasized.
authors.affiliation: Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA.
authors.forename: Tiago Gil
authors.initials: TG
authors.lastname: Oliveira
authors.forename: Gilbert
authors.initials: G
authors.lastname: Di Paolo
mesh_terms: D000544:Alzheimer Disease / Q000201:enzymology / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009410:Nerve Degeneration / Q000209:etiology / Q000378:metabolism; D010739:Phospholipase D / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D010739:Phospholipase D
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