Impaired sperm aggregation in Adam2 and Adam3 null mice.
Previous studies have shown that sperm from Adam2 and Adam3 knockout mice have defective migration in the female reproductive tracts and cannot bind to the egg's zona pellucida (ZP), which leads to infertility. Here, we report that Adam2 and Adam3 knockout sperm have severely impaired sperm aggregation and that this defect is not restored over time during in vitro cultivation, suggesting the requirement of ADAM2 and ADAM3 in normal sperm association.
Han
Cecil
C
Department of Life Science, Gwangju Institute of Science and Technology, Gwangju, South Korea.
Kwon
Jun Tae
JT
Park
Inju
I
Lee
Boyeon
B
Jin
Sora
S
Choi
Heejin
H
Cho
Chunghee
C
D051722:ADAM Proteins / Q000172:deficiency*; D000818:Animals; D002449:Cell Aggregation / Q000502:physiology*; D005260:Female; D000072196:Fertilins; D008297:Male; D008562:Membrane Glycoproteins / Q000172:deficiency*; D051379:Mice; D018345:Mice, Knockout; D013094:Spermatozoa / Q000378:metabolism* / Q000502:physiology; D015044:Zona Pellucida / Q000378:metabolism*
D008562:Membrane Glycoproteins; D051722:ADAM Proteins; C000606458:Adam2 protein, mouse; C485429:Adam3 protein, mouse; D000072196:Fertilins