title: Primary myxoid liposarcoma of the ovary in an adolescent girl: a case report.
abstract: A 13-year-old girl presented with pelvic pain and imaging revealed a large right ovarian cystic mass. Histologic examination showed a malignant myxoid tumor with chicken-wire vasculature characteristic of a myxoid liposarcoma. The morphologic appearances were supported by the presence of the rearrangement of the CHOP gene demonstrated by interphase fluorescent in situ hybridization. There was no evidence that this tumor represented metastatic disease. To the best of our knowledge, primary ovarian myxoid liposarcoma has not been previously reported in the English literature. We present the case and briefly discuss the differential diagnosis.
authors.affiliation: Department of Histopathology, The Royal National Orthopaedic Hospital, Stanmore, HA7 4LP, Middlesex, UK. roberto.tirabosco@rnoh.nhs.uk
authors.forename: Roberto
authors.initials: R
authors.lastname: Tirabosco
authors.forename: Rupali
authors.initials: R
authors.lastname: Arora
authors.forename: Hongtao
authors.initials: H
authors.lastname: Ye
authors.forename: Carol
authors.initials: C
authors.lastname: Brunell
authors.forename: Dina
authors.initials: D
authors.lastname: Halai
authors.forename: Adrienne M
authors.initials: AM
authors.lastname: Flanagan
mesh_terms: D000293:Adolescent; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D018208:Liposarcoma, Myxoid / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000235:genetics / Q000473:pathology* / Q000601:surgery; D051742:Transcription Factor CHOP / Q000235:genetics*
chemical_list: C497249:DDIT3 protein, human; D004273:DNA, Neoplasm; D051742:Transcription Factor CHOP