title: Prospective randomized comparative study of macular thickness following phacoemulsification and manual small incision cataract surgery.
abstract: OBJECTIVE
  To compare macular thickness following uncomplicated phacoemulsification with foldable acrylic lens and manual small incision cataract surgery (MSICS) with non-foldable polymethyl methacrylate (PMMA) lens implantation.
  
  
  METHODS
  Prospective study was carried out with one eye each of 224 patients with senile cataract randomized into two groups, phacoemulsification and MSICS, by simple 1:1 randomization. Following surgery by either of the two methods, macular thickness was measured by optical coherence tomography (OCT) on the 1st, 7th, 42nd and 180th postoperative day. Main outcome measure was postoperative macular thickness.
  
  
  RESULTS
  On the first postoperative day, central subfield mean thickness (CSMT) in MSICS group was 192.8 +/- 17.9 microm and that in phacoemulsification group was 192.1 +/- 27.4 microm, with no significant difference (p = 0.12). On the 7th day, CSMT in MSICS group (198.9 +/- 21.4 microm) was significantly (p = 0.04) more than that in phacoemulsification group (193.1 +/- 19.3 microm). On the 42nd day, CSMT in MSICS group was 207.8 +/- 26.3 microm and that in phacoemulsification group was 198.3 +/- 23 microm, the difference being significant (p = 0.007). Clinically macular oedema was not diagnosed in any of the patients at any visit. The increase in macular thickness was sub-clinical and did not affect final visual outcome in any patient.
  
  
  CONCLUSIONS
  In spite of the greater theoretical risk of increased postoperative inflammation following MSICS, there was no evidence of cystoid macular oedema, either clinically or on OCT. However, chance of sub-clinical increase in CSMT was more following MSICS compared to phacoemulsification.
authors.affiliation: Regional Institute of Ophthalmology, Kolkata, West Bengal, India. sambuddhaghosh@gmail.com
authors.forename: Sambuddha
authors.initials: S
authors.lastname: Ghosh
authors.forename: Indranil
authors.initials: I
authors.lastname: Roy
authors.forename: Pradyot N
authors.initials: PN
authors.lastname: Biswas
authors.forename: Dipankar
authors.initials: D
authors.lastname: Maji
authors.forename: Lakshmi K
authors.initials: LK
authors.lastname: Mondal
authors.forename: Subhalakshmi
authors.initials: S
authors.lastname: Mukhopadhyay
authors.forename: Gautam
authors.initials: G
authors.lastname: Bhaduri
mesh_terms: D000180:Acrylic Resins; D001837:Body Weights and Measures; D002387:Cataract Extraction / Q000379:methods*; D005260:Female; D006801:Humans; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D008266:Macula Lutea / Q000473:pathology*; D008269:Macular Edema / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D018918:Phacoemulsification / Q000379:methods*; D019904:Polymethyl Methacrylate; D011183:Postoperative Complications / Q000175:diagnosis / Q000503:physiopathology; D011446:Prospective Studies; D019591:Pseudophakia / Q000503:physiopathology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology
chemical_list: D000180:Acrylic Resins; D019904:Polymethyl Methacrylate