Menin dynamics and functional insight: take your partners.
Despite the large number of recent findings and novelties, menin, the protein encoded by the gene responsible for multiple endocrine neoplasia type 1 syndrome, still remains a mystery. Although we have extensive knowledge about its interactions and functions, but it seems that we still cannot see the story in its full complexity. Here, the authors summarize recent findings and former basics on menin dynamics and function by following the way from regulation of MEN1 gene transcription and translation towards the role of menin within and outside of the nucleus, highlighting new data on the possible role of its interactions with nuclear receptors.
Balogh
Katalin
K
2nd Department of Medicine, Semmelweis University, 46 Szentkiralyi, Budapest H-1088, Hungary.
Patócs
Attila
A
Hunyady
László
L
Rácz
Károly
K
D002453:Cell Cycle; D002467:Cell Nucleus / Q000235:genetics; D006801:Humans; D018761:Multiple Endocrine Neoplasia Type 1 / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000378:metabolism*
C105373:MEN1 protein, human; D011518:Proto-Oncogene Proteins; D025521:Tumor Suppressor Proteins