One-pot multicomponent synthesis of two novel thiolactone scaffolds.
We designed two novel thiolactone scaffolds. Both scaffolds can be accessed by a convergent Ugi multicomponent reaction (MCR) and are, thus, amenable to library synthesis. Design, stereoselectivity, structures, full experimental details, and virtual libraries will be reported.
Beck
B
B
Department of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Srivastava
S
S
Khoury
K
K
Herdtweck
E
E
Dömling
Alexander
A
D000215:Acylation; D002625:Chemistry, Organic / Q000379:methods*; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009025:Morpholines / Q000138:chemical synthesis / Q000737:chemistry; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry*
D007783:Lactones; D009025:Morpholines; D013876:Thiophenes; C028971:thiamorpholine
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