[Study on the association between severe chronic hepatitis B and HLA-DRB1 gene polymorphism].
OBJECTIVE
To study the association between HLA-DRB1 gene polymorphism and severe chronic hepatitis B.


METHODS
26 patients with severe chronic hepatitis B were investigated for HLA-DRB1 gene polymorphism by polymerase chain reaction-sequence specific primers technique. The results were compared with those from 45 normal healthy people by use of chi2-test of Microsoft SPSS 13.0.


RESULTS
The frequency of HLA-DRB1 * 1301/1302 allele in severe chronic hepatitis B group was significantly higher than the frequency in the control group, while the frequencies of HLA-DRB1 * 1201/1202, 1501/1502 allele were not significantly different.


CONCLUSIONS
HLA-DRB1 * 1301,1302 is closely associated with the suseptibility to severe chronic hepatitis B, While HLA-DRB1 * 1201/1202, 1501/1502 have no association with severe chronic hepatitis B.
Liang
Hong-xia
HX
The Department of Infectious Disease, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Yu
Zu-jiang
ZJ
Jiang
He-qing
HQ
Zhang
Xian-qiang
XQ
D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006515:Hepatitis B virus / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000235:genetics* / Q000473:pathology / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012720:Severity of Illness Index; D055815:Young Adult
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains