NRAMP1 (SLC11A1) variants: genetic susceptibility to multiple Sclerosis.
OBJECTIVE
Multiple sclerosis (MS) is an inflammatory, autoimmune demyelinating disease of the central nervous system. Human Natural Resistance Associated Macrophage Protein 1 (NRAMP1) gene polymorphisms have been implicated in the immune mediated diseases susceptibility. This study aimed to investigate the plausible association between NRAMP1 gene and MS susceptibility.


METHODS
We analyzed (GT)(n,) INT4, 3'UTR and D543N polymorphisms of NRAMP1 gene in 100 MS patients and 104 healthy subjects by using amplification refractory mutation system-polymerase chain reaction and sequence analysis.


RESULTS
No significant association was found between (GT)(n,) INT4, 3'UTR and D543N polymorphisms and MS. There was also no correlation between NRAMP1 polymorphisms and MS clinical forms.


CONCLUSIONS
Our findings suggest that NRAMP1 polymorphisms do not play a role in MS susceptibility and clinical finding of MS in Turkish patients.
Ates
Omer
O
Department of Medical Biology, Medical Faculty, Gaziosmanpasa University, 60100, Tokat, Turkey. omerates27@yahoo.com
Kurt
Semiha
S
Bozkurt
Nihan
N
Karaer
Hatice
H
D016022:Case-Control Studies; D027682:Cation Transport Proteins / Q000235:genetics*; D004252:DNA Mutational Analysis / Q000379:methods; D020022:Genetic Predisposition to Disease; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics*; D011110:Polymorphism, Genetic; D014421:Turkey; D000099173:Natural Resistance-associated Macrophage Protein 1
D027682:Cation Transport Proteins; D000099173:Natural Resistance-associated Macrophage Protein 1
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