Comparison of the Expression of Cell Adhesion Molecule  Markers (E-Cadherin and Syndecan-1) between Young  and Older Age Patients with Gastric Carcinoma.
OBJECTIVE
The aim of this study was to evaluate the relationship between age and cell adhesion molecule markers (E-cadherin and syndecan-1).


METHODS
Forty-three cases of gastric carcinoma below the age of 50 were referred to our center in the period of 5 years (2003–2008). Forty-three gastric carcinoma above the age of 50 years were sex-matched with the first group. Expression of syndecan-1 and E-cadherin were evaluated by immunohistochemistry in a total of 86 gastric carcinomas accompanying with all the clinicopathological findings in each case.


RESULTS
The expression of syndecan-1 and E-cadherin did not show significant difference between two age groups; in addition, there were no significant differences in all the clinicopathological findings in these two age groups.


CONCLUSIONS
Gastric carcinoma in young and old age adults showed no significant difference in respect of the expression of cell adhesion molecule markers. Our result shows that young age alone cannot be predictive of more metastasis and invasion potential.
Geramizadeh
Bita
B
Transplant Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. geramib@sums.ac.ir
Adeli
Omid-Ali
OA
Rahsaz
Marjan
M
Mokhtari
Maral
M
Sefidbakht
Salma
S
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015820:Cadherins / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology; D053668:Syndecan-1 / Q000378:metabolism*; D055815:Young Adult
D015703:Antigens, CD; D014408:Biomarkers, Tumor; C513384:CDH1 protein, human; D015820:Cadherins; C508241:SDC1 protein, human; D053668:Syndecan-1
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