title: Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus.
abstract: BACKGROUND
  Metformin is an oral anti-hyperglycemic agent that has been shown to reduce total mortality compared to other anti-hyperglycemic agents, in the treatment of type 2 diabetes mellitus. Metformin, however, is thought to increase the risk of lactic acidosis, and has been considered to be contraindicated in many chronic hypoxemic conditions that may be associated with lactic acidosis, such as cardiovascular, renal, hepatic and pulmonary disease, and advancing age.
  
  
  OBJECTIVE
  To assess the incidence of fatal and nonfatal lactic acidosis, and to evaluate blood lactate levels, for those on metformin treatment compared to placebo or non-metformin therapies.
  
  
  METHODS
  A comprehensive search was performed of electronic databases to identify studies of metformin treatment. The search was augmented by scanning references of identified articles, and by contacting principal investigators.
  
  
  METHODS
  Prospective trials and observational cohort studies in patients with type 2 diabetes of least one month duration were included if they evaluated metformin, alone or in combination with other treatments, compared to placebo or any other glucose-lowering therapy.
  
  
  METHODS
  The incidence of fatal and nonfatal lactic acidosis was recorded as cases per patient-years, for metformin treatment and for non-metformin treatments. The upper limit for the true incidence of cases was calculated using Poisson statistics. In a second analysis lactate levels were measured as a net change from baseline or as mean treatment values (basal and stimulated by food or exercise) for treatment and comparison groups. The pooled results were recorded as a weighted mean difference (WMD) in mmol/L, using the fixed-effect model for continuous data.
  
  
  RESULTS
  Pooled data from 347 comparative trials and cohort studies revealed no cases of fatal or nonfatal lactic acidosis in 70,490 patient-years of metformin use or in 55,451 patients-years in the non-metformin group. Using Poisson statistics the upper limit for the true incidence of lactic acidosis per 100,000 patient-years was 4.3 cases in the metformin group and 5.4 cases in the non-metformin group. There was no difference in lactate levels, either as mean treatment levels or as a net change from baseline, for metformin compared to non-metformin therapies.
  
  
  CONCLUSIONS
  There is no evidence from prospective comparative trials or from observational cohort studies that metformin is associated with an increased risk of lactic acidosis, or with increased levels of lactate, compared to other anti-hyperglycemic treatments.
authors.affiliation: Medicine, Stanford University, and Santa Clara Valley Medical Center, 2400 Moorpark Ave, Suite 118, San Jose, CA, USA, 95128.
authors.forename: Shelley R
authors.initials: SR
authors.lastname: Salpeter
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Greyber
authors.forename: Gary A
authors.initials: GA
authors.lastname: Pasternak
authors.forename: Edwin E
authors.initials: EE
authors.lastname: Salpeter
mesh_terms: D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000401:mortality; D015331:Cohort Studies; D000075202:Contraindications; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D015994:Incidence; D019344:Lactic Acid / Q000097:blood; D008687:Metformin / Q000009:adverse effects*; D011446:Prospective Studies; D012306:Risk
chemical_list: D007004:Hypoglycemic Agents; D019344:Lactic Acid; D008687:Metformin
references.citation: Clin Invest Med. 1995 Aug;18(4):318-24
references.pmid: 8549019
references.citation: Diabetes Obes Metab. 2009 Jan;11(1):27-32
references.pmid: 17941873
references.citation: Farmaco Prat. 1979 Jan;34(1):32-41
references.pmid: 378687
references.citation: Curr Med Res Opin. 2005 Dec;21(12):2029-35
references.pmid: 16368054
references.citation: Diabete Metab. 1991 May;17(1 Pt 2):235-40
references.pmid: 1936483
references.citation: Diabetologia. 1978 Feb;14(2):75-87
references.pmid: 344119
references.citation: Diabet Med. 2005 Jul;22(7):907-13
references.pmid: 15975107
references.citation: Am J Physiol Endocrinol Metab. 2009 Sep;297(3):E767-73
references.pmid: 19622782
references.citation: Diabetes Res Clin Pract. 2008 Feb;79(2):196-203
references.pmid: 17931733
references.citation: J Diabetes Complications. 2007 May-Jun;21(3):137-42
references.pmid: 17493545
references.citation: Diabet Med. 2001 Oct;18(10):828-34
references.pmid: 11678974
references.citation: Diabetes Care. 2002 Dec;25(12):2123-8
references.pmid: 12453948
references.citation: Clin Ther. 2000 Dec;22(12):1395-409
references.pmid: 11192132
references.citation: Diabet Med. 2007 Sep;24(9):955-61
references.pmid: 17509069
references.citation: Cardiology. 1999;91(3):195-202
references.pmid: 10516414
references.citation: Int J Obes Relat Metab Disord. 1997 Sep;21(9):756-63
references.pmid: 9376887
references.citation: Pharmacotherapy. 2005 Jun;25(6):810-6
references.pmid: 15927899
references.citation: J Egypt Med Assoc. 1978;61(9-10):673-92
references.pmid: 262252
references.citation: Orv Hetil. 1962 Jun 3;103:1029-32
references.pmid: 14458361
references.citation: Acta Diabetol. 2007 Sep;44(3):149-56
references.pmid: 17721754
references.citation: Atherosclerosis. 2008 Apr;197(2):718-24
references.pmid: 17765245
references.citation: Diabetes Care. 1991 Jan;14(1):12-9
references.pmid: 1899368
references.citation: J Clin Endocrinol Metab. 2005 Dec;90(12):6523-8
references.pmid: 16189256
references.citation: Acta Med Austriaca. 1978;5(3):91-5
references.pmid: 752221
references.citation: Int J Clin Pharmacol Ther Toxicol. 1990 Aug;28(8):329-32
references.pmid: 2272714
references.citation: Diabetes Metab Res Rev. 2009 Mar;25(3):224-31
references.pmid: 19156705
references.citation: Srp Arh Celok Lek. 2007 Jul-Aug;135(7-8):447-52
references.pmid: 17929538
references.citation: Diabetes Res Clin Pract. 2001 Mar;51(3):205-13
references.pmid: 11269893
references.citation: Endocr Pract. 2009 May-Jun;15(4):343-8
references.pmid: 19454394
references.citation: Diabet Med. 1996 May;13(5):471-7
references.pmid: 8737030
references.citation: Diabet Med. 2002 Feb;19(2):136-43
references.pmid: 11874430
references.citation: Diabet Med. 1999 Sep;16(9):755-61
references.pmid: 10510952
references.citation: Diabetes Care. 1990 Jan;13(1):1-8
references.pmid: 2404714
references.citation: Diabetes Res Clin Pract. 2007 Oct;78(1):132-5
references.pmid: 17445933
references.citation: Diabetes Res Clin Pract. 2008 Mar;79(3):453-60
references.pmid: 18160120
references.citation: Exp Clin Endocrinol Diabetes. 1999;107 Suppl 4:S136-9
references.pmid: 10522839
references.citation: Int J Clin Pract. 2009 Jan;63(1):46-55
references.pmid: 19125992
references.citation: Diabetes Metab Rev. 1995 Sep;11 Suppl 1:S57-62
references.pmid: 8529486
references.citation: Br Med J. 1968 Oct 5;4(5622):25-8
references.pmid: 5677210
references.citation: Clin Nutr. 2006 Aug;25(4):606-16
references.pmid: 16698134
references.citation: Diabetes Obes Metab. 2001 Oct;3(5):319-25
references.pmid: 11703421
references.citation: Eur J Endocrinol. 2009 Sep;161(3):391-5
references.pmid: 19528204
references.citation: Diabetes Care. 1996 Mar;19(3):252-4
references.pmid: 8742572
references.citation: Scand J Prim Health Care. 2007 Sep;25(3):147-53
references.pmid: 17846932
references.citation: Diabetologia. 1978 Aug;15(2):95-8
references.pmid: 700278
references.citation: Diabete Metab. 1991 May;17(1 Pt 2):209-12
references.pmid: 1936478
references.citation: Cochrane Database Syst Rev. 2005 Jul 20;(3):CD002966
references.pmid: 16034881
references.citation: Diabete Metab. 1995 Oct;21(4):274-80
references.pmid: 8529763
references.citation: Diabetes Care. 1993 Jul;16(7):1035-8
references.pmid: 8359098
references.citation: Metabolism. 1997 Feb;46(2):227-33
references.pmid: 9030834
references.citation: Diabet Med. 2007 Jul;24(7):714-9
references.pmid: 17403126
references.citation: Ther Ggw. 1975 Sep;114(9):1426-37
references.pmid: 1103353
references.citation: Mt Sinai J Med. 2009 Jun;76(3):234-43
references.pmid: 19421967
references.citation: Diabetes. 1994 Jul;43(7):920-8
references.pmid: 8013758
references.citation: Diabetes Obes Metab. 2008 Sep;10(10):959-69
references.pmid: 18201203
references.citation: Pharmacol Res. 1994 Oct-Nov;30(3):187-228
references.pmid: 7862618
references.citation: Endocr Pract. 2000 Nov-Dec;6(6):442-6
references.pmid: 11155215
references.citation: Intern Med. 2008;47(13):1181-8
references.pmid: 18591838
references.citation: Diabete Metab. 1994 Jul-Aug;20(4):394-400
references.pmid: 7843470
references.citation: Diabetes Care. 2005 May;28(5):995-1000
references.pmid: 15855556
references.citation: Obes Res. 2001 Nov;9(11):662-7
references.pmid: 11707532
references.citation: JAMA. 2000 Apr 5;283(13):1695-702
references.pmid: 10755495
references.citation: Clin Ther. 2000 Jun;22(6):709-18
references.pmid: 10929918
references.citation: J Clin Endocrinol Metab. 1995 Apr;80(4):1369-75
references.pmid: 7536208
references.citation: Diabetes Care. 1997 Dec;20(12):1863-9
references.pmid: 9405908
references.citation: Diabetes. 2002 Feb;51(2):443-8
references.pmid: 11812753
references.citation: Clin Chem Lab Med. 2001 Sep;39(9):818-21
references.pmid: 11601679
references.citation: Diabet Med. 1998 Aug;15(8):651-6
references.pmid: 9702467
references.citation: Nutr Metab Cardiovasc Dis. 2008 Jun;18(5):373-9
references.pmid: 17919894
references.citation: Diabetes. 1985 Aug;34(8):793-8
references.pmid: 2862087
references.citation: Acta Diabetol. 2009 Jun;46(2):113-8
references.pmid: 18839053
references.citation: Ann Intern Med. 1996 Jan 1;124(1 Pt 2):136-45
references.pmid: 8554206
references.citation: Diabetes Care. 2006 Jan;29(1):170-1
references.pmid: 16373921
references.citation: Diabetes Care. 1994 Oct;17(10):1093-9
references.pmid: 7821127
references.citation: Diabetologia. 1989 Aug;32(8):599-605
references.pmid: 2506091
references.citation: Lancet. 1984 Jul 21;2(8395):122-5
references.pmid: 6146033
references.citation: Eur J Clin Pharmacol. 1988;34(2):129-32
references.pmid: 3289948
references.citation: Diabetes Res Clin Pract. 2003 Jun;60(3):161-9
references.pmid: 12757988
references.citation: Clin Ter. 1965 Nov 15;35(3):227-51
references.pmid: 5865542
references.citation: Am J Ther. 2007 Mar-Apr;14(2):194-202
references.pmid: 17414590
references.citation: Diabetes Care. 1999 Jan;22(1):33-7
references.pmid: 10333900
references.citation: Therapie. 1959;14:625-30
references.pmid: 13834497
references.citation: Aust N Z J Med. 1991 Oct;21(5):714-9
references.pmid: 1759920
references.citation: J Clin Pharmacol. 2008 Jun;48(6):696-707
references.pmid: 18372428
references.citation: Diabet Med. 2008 Mar;25(3):333-40
references.pmid: 18307460
references.citation: Thromb Haemost. 1986 Jun 30;55(3):361-5
references.pmid: 3092392
references.citation: Diabetes Res Clin Pract. 1995 Aug;28 Suppl:S151-7
references.pmid: 8529508
references.citation: J Ir Med Assoc. 1960 Dec;47:142-5
references.pmid: 13723763
references.citation: Ann Intern Med. 1999 Aug 17;131(4):281-303
references.pmid: 10454950
references.citation: Diabetes Obes Metab. 2002 Nov;4(6):368-75
references.pmid: 12406033
references.citation: Clin Ther. 1998 Jul-Aug;20(4):691-8
references.pmid: 9737829
references.citation: Diabetes Obes Metab. 2006 Jul;8(4):419-28
references.pmid: 16776749
references.citation: J Clin Endocrinol Metab. 1994 Dec;79(6):1553-60
references.pmid: 7989455
references.citation: Horm Metab Res. 1997 Sep;29(9):411-6
references.pmid: 9370106
references.citation: Diabetes Care. 1987 Jan-Feb;10(1):62-7
references.pmid: 3552515
references.citation: Diabet Med. 1994 Aug-Sep;11(7):701-4
references.pmid: 7955998
references.citation: Int J Clin Pract. 2006 Jul;60(7):783-90
references.pmid: 16846398
references.citation: Diabetes Obes Metab. 2008 Jun;10 Suppl 1:1-7
references.pmid: 18435668
references.citation: Diabetes Care. 1998 Aug;21(8):1301-5
references.pmid: 9702437
references.citation: Diabetes Obes Metab. 2001 Jun;3(3):195-201
references.pmid: 11412284
references.citation: Diabetes Res Clin Pract. 1996 Jul;33(2):83-7
references.pmid: 8879962
references.citation: Clin Ter. 1992 Mar;140(3):259-63
references.pmid: 1568370
references.citation: J Altern Complement Med. 2007 Jan-Feb;13(1):97-102
references.pmid: 17309383
references.citation: Diabetes Care. 2008 Sep;31(9):1761-6
references.pmid: 18509209
references.citation: Diabet Med. 2005 Aug;22(8):973-9
references.pmid: 16026360
references.citation: Diabetes Care. 2002 Dec;25(12):2133-40
references.pmid: 12453950
references.citation: Control Clin Trials. 1996 Feb;17(1):1-12
references.pmid: 8721797
references.citation: Diabetes Care. 1999 Jun;22(6):925-7
references.pmid: 10372243
references.citation: Diabetes Res Clin Pract. 2007 Oct;78(1):34-41
references.pmid: 17374417
references.citation: J Pak Med Assoc. 1998 Nov;48(11):336-8
references.pmid: 10323055
references.citation: Minerva Endocrinol. 1998 Sep;23(3):71-5
references.pmid: 10063324
references.citation: Eur J Clin Pharmacol. 1991;41(3):263-5
references.pmid: 1748145
references.citation: J Clin Endocrinol Metab. 1992 May;74(5):1020-6
references.pmid: 1569149
references.citation: Acta Diabetol. 2000 Mar;37(1):13-8
references.pmid: 10928231
references.citation: Journ Annu Diabetol Hotel Dieu. 1991;:297-314
references.pmid: 1832200
references.citation: Diabetologia. 2009 Oct;52(10):2046-55
references.pmid: 19688338
references.citation: Int J Clin Pract. 2005 Oct;59(10):1131-6
references.pmid: 16178978
references.citation: Exp Clin Endocrinol Diabetes. 2008 Jan;116(1):58-64
references.pmid: 17973208
references.citation: Atherosclerosis. 2009 Jul;205(1):221-6
references.pmid: 19135671
references.citation: JAMA. 1999 Jun 2;281(21):2005-12
references.pmid: 10359389
references.citation: Clin Endocrinol (Oxf). 2006 Dec;65(6):722-8
references.pmid: 17121522
references.citation: Prensa Med Mex. 1971 Jul-Aug;36(7):347-9
references.pmid: 5096256
references.citation: Diabete Metab. 1977 Sep;3(3):183-8
references.pmid: 913750
references.citation: J Indian Med Assoc. 2005 Aug;103(8):447-50
references.pmid: 16363204
references.citation: Diabetes Care. 2000 Nov;23(11):1660-5
references.pmid: 11092289
references.citation: Diabetes Care. 2006 Nov;29(11):2371-7
references.pmid: 17065670
references.citation: Diabet Med. 2005 May;22(5):612-8
references.pmid: 15842517
references.citation: Diabete Metab. 1991 May;17(1 Pt 2):201-8
references.pmid: 1936477
references.citation: N Engl J Med. 2006 Dec 7;355(23):2427-43
references.pmid: 17145742
references.citation: Diabetologia. 2008 Nov;51(11):2031-40
references.pmid: 18769904
references.citation: Diabetes Res Clin Pract. 2008 Nov;82(2):214-8
references.pmid: 18778865
references.citation: Diabetes Obes Metab. 2007 Mar;9(2):194-205
references.pmid: 17300595
references.citation: Med J Aust. 2008 Apr 21;188(8):446-9
references.pmid: 18429709
references.citation: J Diabetes Complications. 2007 Mar-Apr;21(2):118-23
references.pmid: 17331860
references.citation: Diabetes Care. 2006 Nov;29(11):2361-4
references.pmid: 17065668
references.citation: S Afr Med J. 1961 Apr 8;35:286-8
references.pmid: 13713605
references.citation: Diabetes Care. 1993 Apr;16(4):621-9
references.pmid: 8462390
references.citation: Diabetes Obes Metab. 2005 Jan;7(1):28-39
references.pmid: 15642073
references.citation: Diabetes Obes Metab. 2008 Nov;10(11):1039-46
references.pmid: 18355332
references.citation: Riv Eur Sci Med Farmacol. 1989 Feb;11(1):45-9
references.pmid: 2798990
references.citation: Diabetes Care. 1994 Oct;17(10):1100-9
references.pmid: 7821128
references.citation: J Fam Pract. 1998 Nov;47(5 Suppl):S13-22
references.pmid: 9834750
references.citation: Diabetologia. 1993 Aug;36(8):741-4
references.pmid: 8405741
references.citation: Rev Invest Clin. 1992 Jan-Mar;44(1):71-6
references.pmid: 1523352
references.citation: Br Med J (Clin Res Ed). 1984 Jun 30;288(6435):1956-9
references.pmid: 6428619
references.citation: Diabetes Care. 2006 Mar;29(3):554-9
references.pmid: 16505505
references.citation: Diabete Metab. 1975 Mar;1:23-8
references.pmid: 1234063
references.citation: Diabetologia. 1994 Aug;37(8):826-32
references.pmid: 7988785
references.citation: Diabetes Care. 1998 Oct;21(10):1612-8
references.pmid: 9773719
references.citation: Diabet Med. 2005 Aug;22(8):980-5
references.pmid: 16026361
references.citation: Diabetes Care. 1992 Apr;15(4):539-42
references.pmid: 1499473
references.citation: Endocr Pract. 1997 Mar-Apr;3(2):73-6
references.pmid: 15251479
references.citation: Diabet Med. 1995 Feb;12(2):164-72
references.pmid: 7743764
references.citation: Diabetes Metab Res Rev. 2006 Nov-Dec;22(6):477-82
references.pmid: 16634115
references.citation: Diabete Metab. 1991 May;17(1 Pt 2):213-7
references.pmid: 1936479
references.citation: J Am Geriatr Soc. 2007 Feb;55(2):182-8
references.pmid: 17302653
references.citation: Diabetes Care. 2006 Apr;29(4):759-64
references.pmid: 16567811
references.citation: Curr Med Res Opin. 2009 May;25(5):1111-9
references.pmid: 19309251
references.citation: Diabetes Care. 2005 Feb;28(2):266-72
references.pmid: 15677777
references.citation: Horm Metab Res Suppl. 1985;15:105-11
references.pmid: 3935560
references.citation: J Endocrinol Invest. 2009 Jan;32(1):23-7
references.pmid: 19337010
references.citation: Hypertens Res. 2007 Jan;30(1):23-30
references.pmid: 17460368
references.citation: Am J Med. 1997 Dec;103(6):483-90
references.pmid: 9428831
references.citation: Acta Endocrinol (Copenh). 1989 Mar;120(3):257-65
references.pmid: 2648723
references.citation: Metabolism. 1993 Sep;42(9):1217-22
references.pmid: 8412779
references.citation: J Endocrinol Invest. 1998 Dec;21(11):744-7
references.pmid: 9972673
references.citation: Postgrad Med. 2009 May;121(3):5-15
references.pmid: 19491535
references.citation: Diabetes Care. 2002 Jan;25(1):89-94
references.pmid: 11772907
references.citation: Diabete Metab. 1991 Sep-Oct;17(5):483-9
references.pmid: 1752350
references.citation: Clin Sci (Lond). 1987 Jul;73(1):41-5
references.pmid: 3301165
references.citation: Minerva Med. 1961 Aug 18;52:2770-3
references.pmid: 13685617
references.citation: Eur J Clin Pharmacol. 1993;44(6):589-91
references.pmid: 8405019
references.citation: Diabetes. 1995 Jan;44(1):37-42
references.pmid: 7813812
references.citation: Journ Annu Diabetol Hotel Dieu. 1996;:273-88
references.pmid: 8965430
references.citation: J Intern Med. 1998 Aug;244(2):169-74
references.pmid: 10095804
references.citation: Diabet Med. 2005 Sep;22(9):1282-4
references.pmid: 16108864
references.citation: Diabet Med. 1991 May;8(4):361-5
references.pmid: 1713132
references.citation: Diabetologia. 1977 Apr;13(2):145-52
references.pmid: 404205
references.citation: Diabetes Care. 2000 Sep;23(9):1236-41
references.pmid: 10977012
references.citation: Diabetes Res Clin Pract. 1996 Jul;33(2):111-8
references.pmid: 8879966
references.citation: Diabetes Metab Res Rev. 2007 May;23(4):299-303
references.pmid: 16952199
references.citation: Diabetes Care. 2005 Aug;28(8):1936-40
references.pmid: 16043735
references.citation: Diabetes Obes Metab. 2007 Jul;9(4):483-9
references.pmid: 17587390
references.citation: Diabete Metab. 1991 May;17(1 Pt 2):197-200
references.pmid: 1936476
references.citation: Diabete. 1964 Oct;12:239-45
references.pmid: 14228352
references.citation: Diabetes Care. 1998 Sep;21(9):1489-94
references.pmid: 9727896
references.citation: Diabetes Metab Res Rev. 2005 Mar-Apr;21(2):167-74
references.pmid: 15386821
references.citation: Diabetes Res Clin Pract. 2006 Jun;72(3):265-70
references.pmid: 16406190
references.citation: Diabetes Res Clin Pract. 2008 Jul;81(1):42-9
references.pmid: 18394743
references.citation: Diabetes Care. 2005 Mar;28(3):539-43
references.pmid: 15735184
references.citation: Circulation. 2005 Feb 8;111(5):583-90
references.pmid: 15699279
references.citation: Diabete Metab. 1991 May;17(1 Pt 2):224-31
references.pmid: 1936481
references.citation: Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008 Jun;25(3):682-5
references.pmid: 18693456
references.citation: Diabetes Obes Metab. 2008 Apr;10(4):293-300
references.pmid: 18333888
references.citation: Nephrol Dial Transplant. 1994;9 Suppl 4:126-9
references.pmid: 7800245
references.citation: Diabetes Care. 1998 Jan;21(1):87-92
references.pmid: 9538975
references.citation: Int J Clin Pract. 2008 May;62(5):695-700
references.pmid: 18412932
references.citation: Diabete Metab. 1991 May;17(1 Pt 2):218-23
references.pmid: 1936480
references.citation: Diabetes Care. 1995 Mar;18(3):307-14
references.pmid: 7555472
references.citation: Acta Endocrinol (Copenh). 1965 Jul;49:479-86
references.pmid: 14332328
references.citation: Diabete. 1963 Dec;11:342-3
references.pmid: 14097463
references.citation: Acta Med Austriaca. 1978;5(3):88-90
references.pmid: 752220
references.citation: Aten Primaria. 1999 Nov 15;24(8):462-7
references.pmid: 10630028
references.citation: Ann Intern Med. 1999 Mar 2;130(5):389-96
references.pmid: 10068412
references.citation: Bosn J Basic Med Sci. 2008 Nov;8(4):309-12
references.pmid: 19125700
references.citation: Obes Res. 1998 Jan;6(1):47-53
references.pmid: 9526970
references.citation: Curr Med Res Opin. 2009 Mar;25(3):569-83
references.pmid: 19232032
references.citation: Diabet Med. 2007 Jun;24(6):618-25
references.pmid: 17403121
references.citation: Acta Clin Belg. 1961;16:575-89
references.pmid: 14486867
references.citation: Diabetes Res Clin Pract. 2005 May;68(2):167-75
references.pmid: 15860246
references.citation: Diabetologia. 1982 Dec;23(6):507-10
references.pmid: 6818080
references.citation: Diabete Metab. 1986 Aug;12(4):219-24
references.pmid: 3533670
references.citation: Diabetes Care. 1996 Nov;19(11):1185-9
references.pmid: 8908377
references.citation: J Clin Endocrinol Metab. 1996 Nov;81(11):4059-67
references.pmid: 8923861
references.citation: Clin Endocrinol (Oxf). 2007 Feb;66(2):282-9
references.pmid: 17224000
references.citation: Diabet Med. 2005 Aug;22(8):1101-6
references.pmid: 16026380
references.citation: Diabetes. 2005 May;54(5):1459-67
references.pmid: 15855334
references.citation: Diabetes Metab Res Rev. 2008 Mar-Apr;24(3):231-7
references.pmid: 17966969
references.citation: Horm Metab Res. 1996 Feb;28(2):89-94
references.pmid: 8867905
references.citation: J Proteome Res. 2009 Apr;8(4):1623-30
references.pmid: 19714868
references.citation: Atherosclerosis. 1990 May;82(1-2):97-103
references.pmid: 2193640
references.citation: J Clin Endocrinol Metab. 2004 Dec;89(12):6068-76
references.pmid: 15579760
references.citation: Diabetes Res Clin Pract. 2008 Jul;81(1):56-60
references.pmid: 18358555
references.citation: Kardiologiia. 2008;48(3):58-68
references.pmid: 18429758
references.citation: JAMA. 1995 Feb 1;273(5):408-12
references.pmid: 7823387
references.citation: Horm Metab Res. 1989 Jun;21(6):317-9
references.pmid: 2777189
references.citation: J Diabetes Complications. 1999 Mar-Apr;13(2):62-7
references.pmid: 10432168
references.citation: BMJ. 2007 Sep 8;335(7618):497
references.pmid: 17761999
references.citation: Diabetologia. 1999 Apr;42(4):406-12
references.pmid: 10230643
references.citation: Diabetes Care. 2004 Jun;27(6):1349-57
references.pmid: 15161787
references.citation: N Engl J Med. 1995 Aug 31;333(9):550-4
references.pmid: 7623903
references.citation: Diabetes Care. 1998 Oct;21(10):1659-63
references.pmid: 9773726
references.citation: Acta Diabetol. 2009 Mar;46(1):75-7
references.pmid: 18820825
references.citation: Int J Cardiol. 2008 May 23;126(2):247-51
references.pmid: 17512619
references.citation: Diabetes. 2008 Jan;57(1):24-31
references.pmid: 17914032
references.citation: Diabet Med. 1996 Aug;13(8):753-7
references.pmid: 8862952
references.citation: Klin Wochenschr. 1983 Sep 1;61(17):851-8
references.pmid: 6632727
references.citation: Clin Sci (Lond). 2008 Feb;114(3):251-6
references.pmid: 17922677
references.citation: Hormones (Athens). 2008 Jan-Mar;7(1):70-6
references.pmid: 18359746
references.citation: Wien Klin Wochenschr. 1978 May 12;90(10):332-7
references.pmid: 654296
references.citation: Naika Hokan. 1962;9:405-7
references.pmid: 13979113
references.citation: Przegl Lek. 1999;56(5):335-41
references.pmid: 10554569
references.citation: Lancet. 1998 Sep 12;352(9131):854-65
references.pmid: 9742977
references.citation: Diabetes Care. 1998 Oct;21(10):1587-8
references.pmid: 9773715
references.citation: Diabetologia. 2005 Dec;48(12):2477-81
references.pmid: 16283239
references.citation: Diabetes Obes Metab. 2007 May;9(3):394-407
references.pmid: 17391168
references.citation: N Engl J Med. 1998 Mar 26;338(13):867-72
references.pmid: 9516221
references.citation: Am J Hypertens. 2004 Mar;17(3):223-7
references.pmid: 15001195
references.citation: S Afr Med J. 1977 Aug 13;52(8):301-2
references.pmid: 897932
references.citation: Ann Intern Med. 1994 Dec 15;121(12):928-35
references.pmid: 7734015
references.citation: Lancet. 1965 Aug 7;2(7406):256-9
references.pmid: 14330058
references.citation: Diabete Metab. 1984 Oct;10(4):219-23
references.pmid: 6391973
references.citation: Diabetes Care. 1998 Dec;21(12):2050-5
references.pmid: 9839093
references.citation: Diabetes Care. 2009 Jan;32(1):84-90
references.pmid: 18931095
references.citation: Curr Med Res Opin. 2008 Feb;24(2):537-50
references.pmid: 18194595
references.citation: Diabetes Care. 2001 Nov;24(11):1957-60
references.pmid: 11679464
references.citation: Diabetes Obes Metab. 2007 Jul;9(4):512-20
references.pmid: 17587394
references.citation: Curr Med Res Opin. 2006 Apr;22(4):751-9
references.pmid: 16684436
references.citation: J Am Board Fam Pract. 1997 May-Jun;10(3):213-21
references.pmid: 9159660
references.citation: J Intern Med. 2009 Apr;265(4):476-87
references.pmid: 19298459
references.citation: J R Soc Med. 1989 Feb;82(2):93-4
references.pmid: 2647992
references.citation: Br Med J. 1977 Dec 17;2(6102):1576-8
references.pmid: 589351
references.citation: Am J Cardiol. 1991 Apr 15;67(9):843-7
references.pmid: 1707221
references.citation: Diabetes. 2002 Jan;51(1):30-6
references.pmid: 11756319
references.citation: Metabolism. 1985 Oct;34(10):923-5
references.pmid: 4046836
references.citation: Diabetes Obes Metab. 2007 Sep;9(5):733-45
references.pmid: 17593236
references.citation: Ann Intern Med. 1999 Aug 3;131(3):182-8
references.pmid: 10428734
references.citation: Diabetes Care. 1996 Jan;19(1):64-6
references.pmid: 8720537
references.citation: Diabetes Care. 2008 Nov;31(11):2086-91
references.pmid: 18782901
references.citation: Diabetes Care. 2001 Jun;24(6):989-94
references.pmid: 11375358
references.citation: Diabet Med. 1988 Oct;5(7):653-8
references.pmid: 2975549
references.citation: Can Fam Physician. 2008 Apr;54(4):550-8
references.pmid: 18411384
references.citation: Diabetes Care. 2007 Apr;30(4):790-4
references.pmid: 17392540
references.citation: Rev Invest Clin. 2004 May-Jun;56(3):327-33
references.pmid: 15612515
references.citation: Clin Ther. 2003 Mar;25(3):890-903
references.pmid: 12852706
references.citation: Curr Med Res Opin. 2008 Sep;24(9):2437-47
references.pmid: 18662495
references.citation: Clin Ter. 1992 Dec;141(12):483-92
references.pmid: 1493670
references.citation: J Assoc Physicians India. 2007 May;55:333-7
references.pmid: 17844692
references.citation: J Clin Pathol. 1988 Sep;41(9):933-5
references.pmid: 3192752
references.citation: Ther Drug Monit. 1999 Jun;21(3):330-4
references.pmid: 10365648
references.citation: J Am Coll Cardiol. 2001 Apr;37(5):1344-50
references.pmid: 11300445
references.citation: Diabetes Obes Metab. 2007 Jul;9(4):506-11
references.pmid: 17587393
references.citation: Diabete Metab. 1995 Oct;21(4):256-60
references.pmid: 8529760
references.citation: Diabetologia. 2006 May;49(5):930-6
references.pmid: 16525843
references.citation: J Med Assoc Thai. 1995 Nov;78(11):578-85
references.pmid: 8576667
references.citation: Arch Med Res. 1992 Spring;23(1):19-24
references.pmid: 1308787
references.citation: Metabolism. 2005 Mar;54(3):314-20
references.pmid: 15736108
references.citation: Eur J Nucl Med Mol Imaging. 2008 Jan;35(1):95-9
references.pmid: 17786437
references.citation: Eur Heart J. 2008 Jan;29(2):166-76
references.pmid: 18156614
references.citation: Arch Intern Med. 2002 Feb 25;162(4):434-7
references.pmid: 11863476
references.citation: Diabetes Obes Metab. 2008 Aug;10(8):652-60
references.pmid: 17941876
references.citation: J Med Lyon. 1966 Mar 5;47(94):407-13
references.pmid: 5909923
references.citation: Clin Pharmacokinet. 1996 May;30(5):359-71
references.pmid: 8743335
references.citation: Rev Invest Clin. 1978 Apr-Jun;30(2):131-4
references.pmid: 353940
references.citation: Presse Med (1893). 1962 Oct 20;70:2038-40
references.pmid: 14018300
references.citation: Ann Intern Med. 2008 Oct 21;149(8):531-9
references.pmid: 18936501
references.citation: Diabetes Care. 1999 Jun;22(6):960-4
references.pmid: 10372249
references.citation: Diabete Metab. 1989 Nov-Dec;15(6):420-5
references.pmid: 2534084
references.citation: Clin Cardiol. 2001 Feb;24(2):151-8
references.pmid: 11460818
references.citation: Intern Med. 2009;48(5):265-71
references.pmid: 19252346
references.citation: Rev Med Liege. 1965 Nov 15;20(22):607-13
references.pmid: 5854952
references.citation: Diabetes Res Clin Pract. 1997 Jul;37(1):21-33
references.pmid: 9279474
references.citation: Diabetes Obes Metab. 2002 May;4(3):201-8
references.pmid: 12047399
references.citation: Wien Klin Wochenschr. 1964 May 8;76:335-7
references.pmid: 14222131
references.citation: Prensa Med Mex. 1969 Sep-Oct;34(9):378-81
references.pmid: 5378263
references.citation: Med Clin (Barc). 2008 Nov 29;131(19):721-30
references.pmid: 19091199
references.citation: Postgrad Med J. 1996 Jun;72(848):352-4
references.pmid: 8758014
references.citation: Neth J Med. 2000 Mar;56(3):86-90
references.pmid: 10759019
references.citation: Q J Med. 1988 Feb;66(250):137-46
references.pmid: 3051084
references.citation: J Indian Med Assoc. 1963 Feb 16;40:151-5
references.pmid: 13934517
references.citation: Braz J Med Biol Res. 2006 Apr;39(4):489-94
references.pmid: 16612472
references.citation: Diabetes Care. 1999 Jan;22(1):119-24
references.pmid: 10333912
references.citation: Am Heart J. 2007 Mar;153(3):445.e1-6
references.pmid: 17307426
references.citation: Sem Hop. 1961 Jan 20;37:247-54
references.pmid: 13739320
references.citation: Horm Metab Res. 2009 May;41(5):368-73
references.pmid: 19221978
references.citation: Diabet Med. 1990 Mar-Apr;7(3):242-5
references.pmid: 2158410
references.citation: Diabete Metab. 1986 Dec;12(6):346-50
references.pmid: 3817257
references.citation: J Intern Med. 2003 Nov;254(5):455-63
references.pmid: 14535967
references.citation: Br Med J. 1962 Mar 10;1(5279):680-2
references.pmid: 13900753
references.citation: Horm Metab Res. 2008 Jul;40(7):491-7
references.pmid: 18401838
references.citation: Diabete Metab. 1991 May;17(1 Pt 2):174-9
references.pmid: 1936472
references.citation: Diabete Metab. 1991 May;17(1 Pt 2):180-4
references.pmid: 1936473
references.citation: Eur J Endocrinol. 2008 May;158(5):631-41
references.pmid: 18426821
references.citation: Metabolism. 2003 Jul;52(7):862-7
references.pmid: 12870162
references.citation: J Assoc Physicians India. 2005 May;53:441-5
references.pmid: 16124352
references.citation: Medicina (Firenze). 1989 Apr-Jun;9(2):200-4
references.pmid: 2682123
references.citation: Diabetes Care. 2009 Apr;32(4):650-7
references.pmid: 19114612
references.citation: JAMA. 2000 Apr 19;283(15):2008-12
references.pmid: 10789670
references.citation: Diabetologia. 2006 Feb;49(2):375-82
references.pmid: 16395615
references.citation: Diabetes Res Clin Pract. 2008 Jan;79(1):42-7
references.pmid: 17714824
references.citation: Diabet Med. 2006 Oct;23(10):1069-78
references.pmid: 16978370
references.citation: Clin Ther. 2005 Oct;27(10):1535-47
references.pmid: 16330290
references.citation: Arzneimittelforschung. 1999 Apr;49(4):330-4
references.pmid: 10337452
references.citation: Diabetes Care. 1991 Apr;14(4):342-4
references.pmid: 2060439
references.citation: Diabete. 1966 Feb;14(2):75-9
references.pmid: 5910138
references.citation: Diabet Med. 1992 May;9(4):341-3
references.pmid: 1600704
references.citation: Diabetes Obes Metab. 2001 Oct;3(5):326-31
references.pmid: 11703422
references.citation: Diabet Med. 2005 May;22(5):634-40
references.pmid: 15842521
references.citation: Diabetes Care. 1997 Jun;20(6):925-8
references.pmid: 9167101
references.citation: J Pak Med Assoc. 2000 Nov;50(11):381-6
references.pmid: 11126815
references.citation: Diabetes Obes Metab. 2003 May;5(3):163-70
references.pmid: 12681023
references.citation: Endocr J. 2007 Apr;54(2):247-53
references.pmid: 17303931
references.citation: BMJ. 1995 Jan 14;310(6972):83-8
references.pmid: 7833731
references.citation: Diabetes Res Clin Pract. 1989 Jan 3;6(1):61-7
references.pmid: 2702918
references.citation: Acta Diabetol Lat. 1990 Apr-Jun;27(2):139-55
references.pmid: 2198745
references.citation: J Clin Pharm Ther. 2006 Aug;31(4):375-83
references.pmid: 16882108
references.citation: Diabetes Care. 1998 Dec;21(12):2135-9
references.pmid: 9839106
references.citation: Diabete Metab. 1994 Jan-Feb;20(1):15-9
references.pmid: 8056129
references.citation: Practitioner. 1964 Apr;192:567-72
references.pmid: 14143336
references.citation: Diabetes Care. 1999 Jan;22(1):38-44
references.pmid: 10333901
references.citation: Diabetes Care. 2004 Jan;27(1):41-6
references.pmid: 14693964
references.citation: Diabet Med. 1997 Sep;14(9):798-802
references.pmid: 9300232
references.citation: Diabetes Res Clin Pract. 1995 Aug;28 Suppl:S167-72
references.pmid: 8529510
references.citation: Diabetes Care. 2005 Oct;28(10):2345-51
references.pmid: 16186261
references.citation: Diabet Med. 2002 Aug;19(8):673-80
references.pmid: 12147149
references.citation: Horm Metab Res. 2006 Dec;38(12):838-44
references.pmid: 17163361
references.citation: Gaz Med Fr. 1965 Jul 25;72(14):2763-5
references.pmid: 5850517
references.citation: Diabet Med. 1987 Sep-Oct;4(5):457-62
references.pmid: 2959438
references.citation: Diabetes Care. 1999 May;22(5):859
references.pmid: 10332699
references.citation: Acta Med Scand. 1979;206(4):269-73
references.pmid: 506799
references.citation: Diabet Med. 1999 Aug;16(8):692-6
references.pmid: 10477216
references.citation: J Indian Med Assoc. 2008 Jul;106(7):464-7
references.pmid: 18975505
references.citation: Saudi Med J. 2006 Oct;27(10):1483-8
references.pmid: 17013468
references.citation: Prensa Med Mex. 1973 Jul-Aug;38(7):281-2
references.pmid: 4789184
references.citation: J Clin Pharmacol. 1996 Nov;36(11):1012-21
references.pmid: 8973990
references.citation: Metabolism. 2007 Oct;56(10):1418-24
references.pmid: 17884455
references.citation: Korean J Intern Med. 1992 Jul;7(2):81-6
references.pmid: 1306076
references.citation: Diabetes Metab Res Rev. 1999 Nov-Dec;15(6):400-4
references.pmid: 10634965
references.citation: Diabetes. 1999 Jan;48(1):198-202
references.pmid: 9892243
references.citation: Diabetes Care. 1996 Feb;19(2):160-4
references.pmid: 8718438
references.citation: Med Welt. 1975 Mar 14;26(11):516-9
references.pmid: 1091803
references.citation: Arch Med Res. 2008 May;39(4):412-9
references.pmid: 18375253
references.citation: Clin Ther. 1999 Oct;21(10):1678-87
references.pmid: 10566564
references.citation: JAMA. 2009 Sep 16;302(11):1186-94
references.pmid: 19755697
references.citation: Atherosclerosis. 2008 Aug;199(2):362-7
references.pmid: 18206891
references.citation: J Med Lyon. 1966 Mar 5;47(94):395-404
references.pmid: 5909922
references.citation: Pak J Pharm Sci. 2007 Jan;20(1):67-71
references.pmid: 17337432
references.citation: Diabete Metab. 1979 Sep;5(3):223-9
references.pmid: 574098
references.citation: Br Med J. 1978 Aug 12;2(6135):464-6
references.pmid: 678924
references.citation: Diabetes Obes Metab. 2009 May;11(5):506-15
references.pmid: 19320662
references.citation: Diabetes Technol Ther. 2007 Aug;9(4):387-98
references.pmid: 17705695
references.citation: J Clin Endocrinol Metab. 2003 Apr;88(4):1637-45
references.pmid: 12679450
references.citation: Diabetes. 1987 May;36(5):632-40
references.pmid: 3552795
references.citation: J Fam Pract. 1999 Nov;48(11):879-82
references.pmid: 10907625
references.citation: Minerva Endocrinol. 1996 Sep;21(3):101-10
references.pmid: 9072666
references.citation: Diabetes Obes Metab. 2009 Aug;11(8):804-12
references.pmid: 19476473
references.citation: Diabet Med. 1989 Apr;6(3):249-56
references.pmid: 2523787
references.citation: Wien Med Wochenschr. 1963 Aug 3;113:599-602
references.pmid: 13983969
references.citation: Diabetes. 1983 Dec;32(12):1083-6
references.pmid: 6360756
references.citation: Exp Clin Endocrinol Diabetes. 2008 Jan;116(1):6-13
references.pmid: 18095238
references.citation: N Engl J Med. 1996 Feb 29;334(9):574-9
references.pmid: 8569826
references.citation: Lancet. 2009 Jun 20;373(9681):2125-35
references.pmid: 19501900
references.citation: Transl Res. 2008 Jun;151(6):309-14
references.pmid: 18514142
references.citation: Diabetes Care. 1996 Sep;19(9):934-9
references.pmid: 8875085
references.citation: Am J Ther. 2008 Jul-Aug;15(4):409-16
references.pmid: 18645347
references.citation: Rev Invest Clin. 1998 Sep-Oct;50(5):389-94
references.pmid: 9949668
references.citation: Ann Intern Med. 2005 Oct 18;143(8):559-69
references.pmid: 16230722
references.citation: Acta Diabetol. 1999 Jun;36(1-2):61-5
references.pmid: 10436254
references.citation: Diabetes. 1995 Nov;44(11):1249-58
references.pmid: 7589820
references.citation: J Int Med Res. 2005 May-Jun;33(3):284-94
references.pmid: 15938589
references.citation: Diabetes Obes Metab. 2007 Mar;9(2):186-93
references.pmid: 17300594
references.citation: Diabet Med. 1994 Dec;11(10):953-60
references.pmid: 7895460
references.citation: Diabetes Res. 1992 Feb;19(2):69-76
references.pmid: 1286541
references.citation: Diabet Med. 1998 Dec;15(12):997-1002
references.pmid: 9868971
references.citation: Diabetes Care. 2002 Oct;25(10):1691-8
references.pmid: 12351463
references.citation: Rev Fr Endocrinol Clin. 1961 Jul-Aug;2:347-52
references.pmid: 14036692
references.citation: Med J Aust. 1970 Feb 7;1(6):271-3
references.pmid: 5440868
references.citation: Med Welt. 1965 Dec 4;49:2743-6
references.pmid: 5884734
references.citation: Diabetes Obes Metab. 2008 Mar;10(3):238-45
references.pmid: 18269639
references.citation: Arch Med Res. 2000 Nov-Dec;31(6):571-5
references.pmid: 11257323
references.citation: Metabolism. 2007 Aug;56(8):1087-92
references.pmid: 17618954
references.citation: N Engl J Med. 1998 Jan 22;338(4):265-6
references.pmid: 9441244
references.citation: Am J Manag Care. 1999 Jan;5(1):62-8
references.pmid: 10345968
references.citation: Diabetes Obes Metab. 2006 Jan;8(1):39-48
references.pmid: 16367881
references.citation: Diabetes Care. 2009 Jul;32(7):1224-30
references.pmid: 19289857
references.citation: Diabetes Obes Metab. 2006 Mar;8(2):156-63
references.pmid: 16448519
references.citation: Diabet Med. 1990 Jul;7(6):510-4
references.pmid: 2142054
references.citation: J Diabetes Complications. 1998 Mar-Apr;12(2):110-9
references.pmid: 9559489
references.citation: Diabetes Res Clin Pract. 2009 Jan;83(1):69-76
references.pmid: 19019476
references.citation: Ann Intern Med. 1980 Feb;92(2 Pt 1):227-37
references.pmid: 6766289
references.citation: Gaz Med Fr. 1960 Jul 10;67:1555-8
references.pmid: 13795379
references.citation: Rev Clin Esp. 2000 Feb;200(2):74-6
references.pmid: 10776038
references.citation: Clin Ther. 2007 May;29(5):844-855
references.pmid: 17697903
references.citation: Diabetes Care. 2009 Jul;32(7):1237-43
references.pmid: 19366970
references.citation: Eur J Intern Med. 2002 Oct;13(7):428
references.pmid: 12384131
references.citation: Diabetes. 2000 Dec;49(12):2063-9
references.pmid: 11118008
references.citation: Diabetes Care. 1998 Jul;21(7):1154-8
references.pmid: 9653611
references.citation: Eur J Clin Pharmacol. 1993;44(2):107-12
references.pmid: 8453955
references.citation: Acta Diabetol. 2008 Mar;45(1):53-9
references.pmid: 18180864
references.citation: Diabetes Care. 1997 May;20(5):692-7
references.pmid: 9135928
references.citation: Diabetes Care. 2007 Aug;30(8):1979-87
references.pmid: 17485570
references.citation: Med Princ Pract. 2009;18(4):266-71
references.pmid: 19494532
references.citation: Curr Med Res Opin. 2009 May;25(5):1265-72
references.pmid: 19364302
references.citation: Curr Med Res Opin. 2007 Aug;23(8):1775-81
references.pmid: 17712875
references.citation: Int J Obes (Lond). 2007 Jan;31(1):138-46
references.pmid: 16703004
references.citation: Br Med J (Clin Res Ed). 1983 Mar 12;286(6368):830-1
references.pmid: 6403102
references.citation: Metabolism. 2009 Aug;58(8):1059-66
references.pmid: 19394976
references.citation: Ann Pharmacother. 1997 Apr;31(4):474-80
references.pmid: 9101010
references.citation: Georgian Med News. 2007 Apr;(145):52-5
references.pmid: 17525501
references.citation: Diabetes Obes Metab. 2009 Jun;11(6):611-22
references.pmid: 19515181
references.citation: Diabetes Res Clin Pract. 1996 Jun;33(1):53-8
references.pmid: 8877276
references.citation: N Engl J Med. 2008 Oct 9;359(15):1577-89
references.pmid: 18784090
references.citation: Metabolism. 1999 Jul;48(7):897-903
references.pmid: 10421233
references.citation: Am J Med. 1970 Feb;48(2):209-25
references.pmid: 4906508
references.citation: Curr Med Res Opin. 2006 Oct;22(10):1939-47
references.pmid: 17022853
references.citation: Circulation. 2009 Apr 21;119(15):2069-77
references.pmid: 19349323
references.citation: Horm Metab Res. 2008 Dec;40(12):892-5
references.pmid: 18726829
references.citation: Diabetes. 1999 Dec;48(12):2414-21
references.pmid: 10580431
references.citation: Ir J Med Sci. 1964 Jan;457:3-11
references.pmid: 14113902
references.citation: Exp Clin Endocrinol Diabetes. 2006 Oct;114(9):527-32
references.pmid: 17115351
references.citation: Ann Intern Med. 2001 May 1;134(9 Pt 1):737-45
references.pmid: 11329231
references.citation: Am J Med. 1997 Dec;103(6):491-7
references.pmid: 9428832
references.citation: J Clin Endocrinol Metab. 1991 Dec;73(6):1294-301
references.pmid: 1955512
references.citation: Arch Intern Med. 1992 Nov;152(11):2333-6
references.pmid: 1444694
references.citation: Ann Intern Med. 2007 Sep 18;147(6):386-99
references.pmid: 17638715
references.citation: Diabetes Care. 2000 Sep;23(9):1227-31
references.pmid: 10977010
references.citation: Z Allgemeinmed. 1975 May 20;51(14):681-3
references.pmid: 1108460
references.citation: Diabetes Care. 1998 May;21(5):701-5
references.pmid: 9589227
references.citation: Eur J Clin Pharmacol. 1983;25(1):41-5
references.pmid: 6352281
references.citation: Intern Med. 2007;46(22):1837-46
references.pmid: 18025765
references.citation: Diabetologia. 1982 Jul;23(1):34-6
references.pmid: 6749582
references.citation: CMAJ. 2006 Jan 17;174(2):169-74
references.pmid: 16415461
references.citation: Diabetes Care. 1995 Jun;18(6):779-84
references.pmid: 7555503
references.citation: J Clin Endocrinol Metab. 1983 Oct;57(4):713-8
references.pmid: 6350337
references.citation: Diabete Metab. 1991 May;17(1 Pt 2):232-4
references.pmid: 1936482
references.citation: Diabet Med. 2009 Apr;26(4):409-15
references.pmid: 19388972
references.citation: Ann Intern Med. 1998 Feb 1;128(3):165-75
references.pmid: 9454524
references.citation: Cardiovasc Diabetol. 2008 Apr 24;7:10
references.pmid: 18435852
references.citation: Diabetes Care. 2005 Sep;28(9):2093-9
references.pmid: 16123472
references.citation: S Afr Med J. 1962 Sep 1;36:727-9
references.pmid: 14450632
references.citation: Horm Metab Res. 2006 Aug;38(8):513-7
references.pmid: 16941277
references.citation: J Intern Med. 2005 Jan;257(1):100-9
references.pmid: 15606381
references.citation: Diabet Med. 1992 Jan-Feb;9(1):61-5
references.pmid: 1551312
references.citation: Diabetes Care. 1999 May;22(5):854
references.pmid: 10332695
references.citation: N Engl J Med. 1995 Aug 31;333(9):541-9
references.pmid: 7623902
references.citation: Lancet. 1968 Jan 20;1(7534):123-6
references.pmid: 4169605
references.citation: Arch Intern Med. 2009 Mar 23;169(6):616-25
references.pmid: 19307526
references.citation: Thromb Haemost. 1998 Jul;80(1):209-10
references.pmid: 9684819
references.citation: Diabetologia. 1983 May;24(5):351-4
references.pmid: 6347782
references.citation: Diabetes. 2004 Aug;53(8):2169-76
references.pmid: 15277403
references.citation: Curr Med Res Opin. 1989;11(5):273-8
references.pmid: 2702849
references.citation: Cardiovasc Diabetol. 2008 Jun 22;7:20
references.pmid: 18570678
references.citation: Diabetes Obes Metab. 2009 Apr;11(4):330-7
references.pmid: 19267711
references.citation: Curr Med Res Opin. 2004 Jun;20(6):883-9
references.pmid: 15200747
references.citation: J Diabetes Complications. 2008 Mar-Apr;22(2):104-11
references.pmid: 18280440
references.citation: Diabetes Care. 2008 Aug;31(8):1672-8
references.pmid: 18458139
references.citation: Diabetes Obes Metab. 2009 Sep;11(9):865-73
references.pmid: 19476470
references.citation: Clin Ther. 2005 Oct;27(10):1548-61
references.pmid: 16330291