title: Microbial events in the hindgut during carbohydrate-induced equine laminitis.
abstract: Equine laminitis is the most serious foot disease of the horse, often resulting in death or euthanasia. Laminitis has long been recognized as an affliction of horses, as has the association of this condition with the ingestion of carbohydrates. Research into the pathophysiology of this condition has been facilitated by the development of reliable models for experimentally inducing laminitis, and DNA-based techniques for profiling complex microbiomes have dramatically increased the knowledge of the microbiology of this disease. Recent studies have provided substantial evidence showing equine hindgut streptococcal species to be the most likely causative agent. Although these studies are not definitive, they provide the foundations for future work to determine the source of laminitis trigger factors and their mechanisms of action.
authors.affiliation: Australian Equine Laminitis Research Unit, School of Veterinary Science, The University of Queensland, St Lucia, Queensland 4072, Australia. g.milinovich@gmail.com
authors.forename: Gabriel J
authors.initials: GJ
authors.lastname: Milinovich
authors.forename: Athol V
authors.initials: AV
authors.lastname: Klieve
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Pollitt
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Trott
mesh_terms: D000824:Animal Nutritional Physiological Phenomena / Q000502:physiology; D000818:Animals; D004040:Dietary Carbohydrates / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D004195:Disease Models, Animal; D005232:Fatty Acids, Volatile / Q000032:analysis / Q000378:metabolism; D005534:Foot Diseases / Q000382:microbiology / Q000662:veterinary*; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006724:Hoof and Claw / Q000473:pathology; D006734:Horse Diseases / Q000382:microbiology*; D006736:Horses; D007249:Inflammation / Q000382:microbiology / Q000662:veterinary*; D009844:Oligosaccharides / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D013291:Streptococcus / Q000378:metabolism*
chemical_list: D004040:Dietary Carbohydrates; D005232:Fatty Acids, Volatile; D009844:Oligosaccharides; C120489:oligofructose