title: [Relations between ALT level and count of HBV special CTL and non-specific CTL in patients with chronic hepatitis B].
abstract: OBJECTIVE
  To explore relations between ALT level and hepatitis B virus (HBV) specific CTL and non-specific CTL in patients with chronic hepatitis B (CHB).
  
  
  METHODS
  148 cases of CHB were divided into three groups according to ALT level. 35 cases in group A, ALT > or =2 x upper limit of normal value (ULN)--5 x ULN (100-250 IU/L); 53 cases in group B, ALT > 5 x ULN-- < or =10 x ULN (251-500 IU/L); 60 cases in group C, ALT > 10 x ULN ( > 500 IU/L). Flow cytometry is used to determine non-specific CTV. HBV specific CTL was tested on 74 cases of CHB (17 in group A, 27 in group B and 30 in group C) with positive (HLA)-A2. Compare HBV specific CTL, non-specific CTL, HBV DNA levels and positive rate of HBeAg.
  
  
  RESULTS
  HBV specific CTL: Group A (0.42 +/- 0.10)% is higher than group B (0.25 +/- 0.08)%, t = 6.37, P < 0.01, group B is higher than group C (0.17 +/- 0.004)%, t = 5.14, P < 0.01; Non-specific CTL: Group A (15.01 +/- 3.01)% is lower than group B (18.1 +/- 5.02)%, t = 2.81, P < 0.01, group B is lower than group C (21.5 +/- 6.11)%, t = 3.07, P < 0.01; HBV DNA level: Group A [(4.97 +/- 0.86) log10 copies/ml] is lower than group B [(5.92 +/- 0.92) log10 copies/ml], t = 4.87, P < 0.01. Group B is lower than group C [(6.37 +/- 0.71) log10 copies/ml], t = 2.92, P < 0.01; Positive HBeAg: Group A (15 cases, 42.86%) is lower than group B (32 cases, 60.38%), chi2 = 2.59, P > 0.05. Group B is lower than group C (41 cases, 68.33%), chi2 = 0.78, P > 0.05. Group A is lower than group C, chi2 = 5.929, P < 0.05.
  
  
  CONCLUSIONS
  The higher the non-specific CTL of patients with CHB is, the higher the ALT level would be, whereas the lower the HBV specific CTL is, the stronger the HBV replication would be.
authors.affiliation: Wuxi Infectious Hospital, Wuzxi 214005, China. gxb188681@sina.com
authors.forename: Xi-bin
authors.initials: XB
authors.lastname: Gu
authors.forename: Xiao-juan
authors.initials: XJ
authors.lastname: Yang
authors.forename: Dong
authors.initials: D
authors.lastname: Wang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Hua
authors.forename: Hang-yuan
authors.initials: HY
authors.lastname: Wu
authors.forename: Yue-qin
authors.initials: YQ
authors.lastname: Xu
authors.forename: Zhong-hua
authors.initials: ZH
authors.lastname: Lu
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000378:metabolism*; D005260:Female; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology* / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000201:enzymology* / Q000276:immunology* / Q000821:virology; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014779:Virus Replication; D055815:Young Adult
chemical_list: D000410:Alanine Transaminase