title: IL-8 -251A/T polymorphism is associated with decreased cancer risk among population-based studies: evidence from a meta-analysis.
abstract: Growing evidence suggests that interleukin-8 (IL-8) play pivotal roles in the pathogenesis of cancer through the modulation of tumour immune response or enhanced angiogenesis. A single nucleotide polymorphism, -251A/T, has been identified in the promoter region of the IL-8 gene and has been shown to influence its production. Results from previous studies on the association of -251A/T polymorphism with different cancer types remained contradictory. To assess the effect of -251A/T of IL-8 on cancer susceptibility, we conducted a meta-analysis, up to May 2009, of 14,876 cases with different cancer types and 18,465 controls from 45 published case-control studies. Summary odds ratios and corresponding 95% confidence intervals (CIs) for IL-8 polymorphism and cancer were estimated using fixed- and random-effects models when appropriate. The AA/AT genotypes were associated with a significantly increased risk of nasopharyngeal carcinoma when compared with TT genotype (OR=1.48; 95% CI, 1.16-1.89). Moreover, significantly elevated risks were observed in 'other cancers', and also in African population when population is concerned. Interestingly, when stratified separately by population-based studies and hospital-based studies, significantly elevated risk was found among hospital-based studies (OR=1.21, 95% CI, 1.07-1.37), whereas significantly decreased risk was found among population-based studies (OR=0.90, 95% CI, 0.83-0.97). This meta-analysis shows that IL-8 -251A/T polymorphism may play a complex role in cancer development.
authors.affiliation: Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China.
authors.forename: Lin-Bo
authors.initials: LB
authors.lastname: Gao
authors.forename: Xin-Min
authors.initials: XM
authors.lastname: Pan
authors.forename: Jing
authors.initials: J
authors.lastname: Jia
authors.forename: Wei-Bo
authors.initials: WB
authors.lastname: Liang
authors.forename: Li
authors.initials: L
authors.lastname: Rao
authors.forename: Hui
authors.initials: H
authors.lastname: Xue
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhu
authors.forename: Shi-Liu
authors.initials: SL
authors.lastname: Li
authors.forename: Mei-Li
authors.initials: ML
authors.lastname: Lv
authors.forename: Wei
authors.initials: W
authors.lastname: Deng
authors.forename: Tian-Yi
authors.initials: TY
authors.lastname: Chen
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Wei
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics* / Q000378:metabolism; D008297:Male; D009369:Neoplasms / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D016209:Interleukin-8