Lifetime physical activity and risk of endometrial cancer.
BACKGROUND
The role of moderate physical activity and life patterns of activity in reducing endometrial cancer risk remains uncertain.


METHODS
We assessed lifetime histories of activity from recreation, transportation, chores, and occupation and other risk factors in a population-based case-control study of endometrial cancer conducted in the San Francisco Bay area. The analysis was based on 472 newly diagnosed cases ascertained by the regional cancer registry and 443 controls identified by random-digit dialing who completed an in-person interview.


RESULTS
Reduced risks associated with greater lifetime physical activity (highest versus lowest tertile) were found for both total activity [odds ratio (OR), 0.61; 95% confidence interval (95% CI), 0.43-0.87; Ptrend=0.01] and activity of moderate intensity (OR, 0.44; 95% CI, 0.30-0.64; Ptrend<0.0001). Compared with women with low lifetime physical activity (below median), those with greater activity throughout life had a higher reduction in risk (OR, 0.62; 95% CI, 0.44-0.88). Inverse associations were stronger in obese and overweight women, but differences were not statistically significantly different from those in normal-weight women.


CONCLUSIONS
These findings suggest that physical activity in adulthood, even of moderate intensity, may be effective in lowering the risk of endometrial cancer, particularly among those at highest risk for this disease.


CONCLUSIONS
The results emphasize the importance of evaluating lifetime histories of physical activity from multiple sources, including both recreational and nonrecreational activities of various intensities, to fully understand the relation between physical activity and disease risk.
John
Esther M
EM
Cancer Prevention Institute of California, 2201 Walnut Avenue, Suite 300, Fremont, CA 94538, USA. Esther.john@cpic.org
Koo
Jocelyn
J
Horn-Ross
Pamela L
PL
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D015444:Exercise; D005260:Female; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D012307:Risk Factors; D018426:SEER Program
Br J Cancer. 1993 Apr;67(4):846-51
8471444
Cancer Causes Control. 2000 Oct;11(9):829-37
11075872
Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):779-85
15824143
Cancer Causes Control. 2009 Sep;20(7):1107-15
19247787
Med Sci Sports Exerc. 1993 Jan;25(1):71-80
8292105
Nat Rev Cancer. 2004 Aug;4(8):579-91
15286738
Int J Cancer. 2009 May 1;124(9):2139-47
19123463
Cancer Causes Control. 2000 Sep;11(8):707-11
11065007
Cancer Res. 2004 Apr 15;64(8):2923-8
15087413
Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):639-48
17416752
Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2136-40
17057024
Cancer Causes Control. 2007 May;18(4):399-413
17297555
Int J Cancer. 2008 Oct 15;123(8):1877-82
18651569
Cancer Epidemiol Biomarkers Prev. 2003 Nov;12(11 Pt 1):1143-52
14652273
Am J Epidemiol. 2001 Nov 15;154(10):924-33
11700247
Cancer Causes Control. 2007 Apr;18(3):243-58
17206535
Ann Epidemiol. 1997 Jan;7(1):46-53
9034406
Int J Cancer. 2007 Jul 15;121(2):347-55
17357139
Int J Cancer. 1999 Jul 2;82(1):38-42
10360818
J Natl Cancer Inst. 2004 Nov 3;96(21):1635-8
15523093
Oncology. 1996 Sep-Oct;53(5):354-9
8784467
Int J Cancer. 2003 May 10;104(6):669-76
12640672
Cancer Causes Control. 1998 Mar;9(2):199-207
9578297
Eur J Cancer Prev. 2009 Aug;18(4):303-6
19542982
Int J Cancer. 1998 May 29;76(5):665-70
9610723
Br J Cancer. 1993 Sep;68(3):584-9
8353048
J Clin Endocrinol Metab. 1988 May;66(5):927-33
3360900
Cancer Causes Control. 2003 Aug;14(6):559-67
12948287
Cancer. 1993 Jun 1;71(11):3620-4
8490910
Epidemiology. 1993 Jul;4(4):342-9
8347745
Am J Epidemiol. 1997 Sep 15;146(6):476-82
9290508
Cancer Res. 1997 Nov 15;57(22):5077-85
9371506
Cancer Epidemiol Biomarkers Prev. 2002 Dec;11(12):1531-43
12496040
J Natl Cancer Inst. 2003 Aug 6;95(15):1158-64
12902445
Am J Epidemiol. 1989 Jun;129(6):1120-31
2729251
Cancer Res. 1988 Jan 15;48(2):246-53
2825969
Eur J Cancer Prev. 1993 Sep;2(5):369-76
8401170
Jpn J Cancer Res. 1996 Sep;87(9):1001-9
8878465
Cancer Causes Control. 1993 Jul;4(4):313-21
8347780