Synthesis and characterization of tin(II) complexes of fluorinated Schiff bases derived from amino acids.
New tin(II) complexes of general formula Sn(L)(2) (L=monoanion of 3-methyl-4-fluoro-acetophenone phenylalanine L(1)H, 3-methyl-4-fluoro-acetophenone alanine L(2)H, 3-methyl-4-fluoro acetophenone tryptophan L(3)H, 3-methyl-4-fluoro-acetophenone valine L(4)H, 3-methyl-4-fluoro-acetophenone isoleucine L(5)H and 3-methyl-4-fluoro-acetophenone glycine L(6)H) have been prepared. It is characterized by elemental analyses, molar conductance measurements and molecular weight determinations. Bonding of these complexes is discussed in terms of their UV-visible, infrared, and nuclear magnetic resonance ((1)H, (13)C, (19)F and (119)Sn NMR) spectral studies. The ligands act as bidentate towards metal ions, via the azomethine nitrogen and deprotonated oxygen of the respective amino acid. Elemental analyses and NMR spectral data of the ligands with their tin(II) complexes agree with their proposed square pyramidal structures. A few representative ligands and their tin complexes have been screened for their antibacterial activities and found to be quite active in this respect.
Singh
Har Lal
HL
Department of Chemistry, Faculty of Engineering & Technology, Mody Institute of Technology and Science, On NH-11, Lakshmangarh, Sikar 332311, Rajasthan, India. hlsingh9@rediffmail.com
D000596:Amino Acids / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D054879:Halogenation; D009682:Magnetic Resonance Spectroscopy; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D017971:Tin Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D012545:Schiff Bases; D017971:Tin Compounds