title: The effectiveness of gefitinib on spinal metastases of lung cancer - report of two cases -.
abstract: Lung cancer has a high mortality rate and is often diagnosed at the metastatic stage. Recently, gefitinib, a molecule target therapeutic drug, has offered a new approach for patients with non-small-cell lung cancer (NSCLC). This report describes the effects of gefitinib on bone metastases in two patients with NSCLC. The pain induced by a bone metastasis was relieved after the administration of gefitinib. Furthermore, the radiographs and CT findings showed sclerotic changes that matched those of the metastatic bone tumor after gefitinib administration in both patients. It is believed that gefitinib inhibited tumor cell proliferation and induced normal bone formation. In patients with NSCLC, gefitinib may be effective in the treatment of bone metastases.
authors.affiliation: Department of Orthopedic Surgery, University of Toyama, Faculty of Medicine, Toyama, Japan.
authors.forename: Mineyuki
authors.initials: M
authors.lastname: Zukawa
authors.forename: Masato
authors.initials: M
authors.lastname: Nakano
authors.forename: Norikazu
authors.initials: N
authors.lastname: Hirano
authors.forename: Keiichi
authors.initials: K
authors.lastname: Mizuhashi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kanamori
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