title: [Outline on the phylogenetic history of Metazoa aging phenomenon (to the study of number of dominating pseudo-scientific concepts in biology of aging)].
abstract: Natural selection is just one of the factors determining genome evolution of Metazoa. But it's not a domineering one along with non-adaptive processes: horizontal gene transfer and input of egoistic genetic elements. That's why in phylogenesis (1) there are more genes of first Metazoa lost than new ones acquired; (2) the appearance of new genes among Metazoa branches is a very rare occasion; (3) genetically Metazoa is a homogeneous group of species with similar set of cellular mechanisms which was established in the course of evolution. The genome of first Metazoa turned to be so successful that evolution connected with organism amplification didn't demand radical changes in the genetic repertoire but it demanded changes in DNA sites regulating genes work. These facts along with the fact of existence of species of Metazoa with negligible aging overturn the core theories of aging biology which consider this or that cellular mechanism to be the initiating factor of organism's aging as sets of cellular mechanisms in aging and non-aging Metazoa forms are practically identical. That's why the basis of aging biology is in essence a collection of theories and dogmas that have never been proved but which are still in use and which have since long ago turned into a dangerous myth standing in the way of progress. If we are interested in progress of biogerontology a number of domineering pseudo scientific dogmas must be revisited. The matter of conservatism in this issue is inappropriate.
authors.forename: A G
authors.initials: AG
authors.lastname: Boĭko
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Labas
authors.forename: A V
authors.initials: AV
authors.lastname: Gordeeva
mesh_terms: D000375:Aging / Q000235:genetics* / Q000502:physiology*; D000818:Animals; D001695:Biology / Q000379:methods* / Q000639:trends; D005853:Geriatrics / Q000379:methods* / Q000639:trends; D006801:Humans; D010802:Phylogeny