title: Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches.
abstract: A typical feature of ageing is a chronic, low-grade inflammation characterized by a general increase in the production of pro-inflammatory cytokines and inflammatory markers ("inflamm-ageing"). This status may slowly damage one or several organs, especially when unfavorable genetic polymorphisms and epigenetic alterations are concomitant, leading to an increased risk of frailty together with the onset of age-related chronic diseases. The contribution of different tissues (adipose tissue, muscle), organs (brain, liver), immune system and ecosystems (gut microbiota) to age-related inflammation ("inflamm-ageing") will be discussed in this review in the context of its onset/progression leading to site-restricted and systemic effects. Moreover, some of the possible strategies and therapies to counteract the different sources of molecular mediators which lead to the age-related inflammatory phenotype will be presented.
authors.affiliation: Department of Experimental Pathology, University of Bologna, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Cevenini
authors.forename: C
authors.initials: C
authors.lastname: Caruso
authors.forename: G
authors.initials: G
authors.lastname: Candore
authors.forename: M
authors.initials: M
authors.lastname: Capri
authors.forename: D
authors.initials: D
authors.lastname: Nuzzo
authors.forename: G
authors.initials: G
authors.lastname: Duro
authors.forename: C
authors.initials: C
authors.lastname: Rizzo
authors.forename: G
authors.initials: G
authors.lastname: Colonna-Romano
authors.forename: D
authors.initials: D
authors.lastname: Lio
authors.forename: D
authors.initials: D
authors.lastname: Di Carlo
authors.forename: M G
authors.initials: MG
authors.lastname: Palmas
authors.forename: M
authors.initials: M
authors.lastname: Scurti
authors.forename: E
authors.initials: E
authors.lastname: Pini
authors.forename: C
authors.initials: C
authors.lastname: Franceschi
authors.forename: S
authors.initials: S
authors.lastname: Vasto
mesh_terms: D000375:Aging / Q000235:genetics / Q000276:immunology* / Q000473:pathology*; D000818:Animals; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology* / Q000473:pathology / Q000628:therapy*; D008136:Longevity / Q000235:genetics / Q000276:immunology*; D009928:Organ Specificity / Q000235:genetics / Q000276:immunology; D014018:Tissue Distribution / Q000235:genetics / Q000276:immunology