title: Correlation between single-slice muscle anatomical cross-sectional area and muscle volume in thigh extensors, flexors and adductors of perimenopausal women.
abstract: Quantitative data on muscle volume (MV) are important for estimating maximal muscle power. The objective of this study was to determine the correlation between anatomical cross-sectional areas (ACSAs) and the MV in thigh muscles (extensors, flexors, adductors, and sartorius) in perimenopausal women, and to identify at which proximal-to-distal level a single-slice ACSA measurement with magnetic resonance imaging (MRI) displays the highest correlation in each of these. Axial MRIs of the thigh were acquired in 41 perimenopausal women aged 50.8 +/- 3.2 years. Segmentation of the extensors, flexors, adductors, and the sartorius was performed between the femoral neck (0%) and the distal end of the intermediate vastus (100%). MVs were determined by numerical integration, and the ACSA was calculated from three-dimensional reconstructions at 10% intervals from proximal to distal. The extensors contributed 50%, the flexors 19%, the adductors 28%, and the sartorius 3% of the total thigh MV. Maximal correlations between ACSA and MV were observed at the 20-40% proximal-to-distal level in the extensors (R (2) = 0.73), at 30% in the adductors (R (2) = 0.82), and at 70% in the flexors (R (2) = 0.72) and sartorius (R (2) = 0.85), respectively. ACSA at 50% displayed the highest overall correlations (R (2) >or= 0.69) with MV for all muscle groups. Single-slice ACSAs from MRI displayed high correlations with MVs. Although the (proximal to distal) measurement locations with the highest correlation varied between the muscle groups, a single slice at the 50% location achieved the best compromise in terms of correlation between ACSA and MV across extensors, flexors, adductors and the sartorius.
authors.affiliation: Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University, Strubergasse 21, 5020 Salzburg, Austria. sebastian.cotofana@pmu.ac.at
authors.forename: S
authors.initials: S
authors.lastname: Cotofana
authors.forename: M
authors.initials: M
authors.lastname: Hudelmaier
authors.forename: W
authors.initials: W
authors.lastname: Wirth
authors.forename: M
authors.initials: M
authors.lastname: Himmer
authors.forename: S
authors.initials: S
authors.lastname: Ring-Dimitriou
authors.forename: A M
authors.initials: AM
authors.lastname: Sänger
authors.forename: F
authors.initials: F
authors.lastname: Eckstein
mesh_terms: D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D053580:Muscle Strength; D018482:Muscle, Skeletal / Q000033:anatomy & histology*; D009716:Numerical Analysis, Computer-Assisted; D009929:Organ Size; D047648:Perimenopause; D052097:Quadriceps Muscle / Q000033:anatomy & histology; D013848:Thigh
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