title: Correlation between an interleukin-6 -572C/G polymorphism and chronic periodontitis.
abstract: Genetic polymorphisms in the interleukin-6 (IL-6) gene are associated with bone homeostasis and diseases characterized by bone loss. The aim of this study was to investigate the correlation between the IL-6-572C/G polymorphism and the risk of chronic periodontitis in a Chinese Han population. The IL-6-572C/G polymorphism was genotyped in 93 patients suffering from chronic periodontitis and 96 control subjects by polymerase chain reaction-restriction fragment length polymorphism. DNA was extracted from the peripheral blood of patients and control subjects and amplified using a polymerase chain reaction. IL-6 genotypes were identified using gel electrophoresis. The IL-6-572 GG genotype and the G allele were more frequent in chronic periodontitis patients than in control subjects (P<.05). When compared with the CC genotype, the odds ratio for chronic periodontitis was 1.88 (95% confidence interval, 1.04 to 3.40; P<.05) for the CG+GG genotype. The frequency of the -572CG+GG genotype was significantly different between the control group and the group with chronic periodontitis. Therefore, the IL-6-572C/G polymorphism may contribute to the susceptibility to chronic periodontitis in the Chinese Han population.
authors.affiliation: Dental College, Zhengzhou University, and Department of Stomatology, Henan Provincial People's Hospital, Henan, China.
authors.forename: Liu
authors.initials: L
authors.lastname: Jingjin
authors.forename: Guan
authors.initials: G
authors.lastname: Zemin
authors.forename: Ma
authors.initials: M
authors.lastname: Xin
authors.forename: Wu
authors.initials: W
authors.lastname: Donghong
authors.forename: Geng
authors.initials: G
authors.lastname: Jianhua
authors.forename: Yi
authors.initials: Y
authors.lastname: Jie
authors.forename: Wang
authors.initials: W
authors.lastname: Yonggong
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D055113:Chronic Periodontitis / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: D015850:Interleukin-6