Effect of thioglycolic acid instillation to stop hair growth on the urethral mucosa after urethroplasty with hairy skin in a rat model.
OBJECTIVE
The aim of this study was to investigate the impact of thioglycolic acid on normal urethral mucosa.


METHODS
Twenty-four rats were used. Three control and three study groups were formed each consisting of 4 rats. Controls groups were given 0.9% NaCl and study groups received thioglycolic acid instillation. The groups were allocated according to the time of urethral resection and the number of thioglycolic acid instillations (2, 4 or 8 instillations). The urethras of the rats were resected and examined under a light microscope in control and study groups 1, 2 and 3 on days 15, 30 and 60.


RESULTS
There was no difference in the urethral mucosa of rats in the study or control groups, and no differences were found when the study groups were compared to each of the other groups at the microscopic level.


CONCLUSIONS
The application of thioglycolic acid is an easy and inexpensive way of clearing urethral hair and does not cause pathological changes in the normal urethral mucosa.
Sunay
Melih
M
1st Clinic of Urology, Ministry of Health Ankara Training and Research Hospital, Ankara, Turkey. dr.m.sunay@gmail.com
Dadali
Mümtaz
M
Emir
Levent
L
Karabulut
Ayhan
A
Erol
Demokan
D
D000818:Animals; D004195:Disease Models, Animal; D006197:Hair / Q000187:drug effects* / Q000254:growth & development*; D007322:Instillation, Drug; D008297:Male; D009092:Mucous Membrane; D051381:Rats; D017208:Rats, Wistar; D016038:Skin Transplantation; D013864:Thioglycolates / Q000008:administration & dosage*; D014521:Urethra / Q000601:surgery*
D013864:Thioglycolates; C017487:2-mercaptoacetate