Increased oral bioavailability of itraconazole and its active metabolite, 7-hydroxyitraconazole, when coadministered with a vitamin C beverage in healthy participants.
Bae
Soo Kyung
SK
Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, 633-165, Gaegum-Dong, Busanjin-Gu, Busan, 614-735, South Korea.
Park
Soo-Jin
SJ
Shim
Eon-Jeong
EJ
Mun
Ji-Hyun
JH
Kim
Eun-Young
EY
Shin
Jae-Gook
JG
Shon
Ji-Hong
JH
D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D001628:Beverages / Q000032:analysis*; D001682:Biological Availability; D001711:Biotransformation; D018592:Cross-Over Studies; D005260:Female; D018565:Food-Drug Interactions; D006207:Half-Life; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D008825:Miconazole / Q000097:blood / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry; D055815:Young Adult
D000935:Antifungal Agents; C084794:hydroxyitraconazole; D017964:Itraconazole; D008825:Miconazole; D001205:Ascorbic Acid