title: Prognostic role of pigment epithelium-derived factor in clear cell renal cell carcinoma.
abstract: OBJECTIVE
  The purpose of this study was to investigate the prognostic significance of pigment epithelium-derived factor (PEDF) in human clear cell renal cell carcinoma (CCRCC) tissues.
  
  
  METHODS
  We investigated the expression of PEDF and its correlation with clinicopathological features in 203 patients who underwent radical nephrectomy for CCRCC. Expression of PEDF and CD34-positive vessels (microvessel density, MVD) in tumor samples was examined by immunohistochemistry. The relationship between PEDF expression and clinicopathologic features including tumor diameter, MVD, and survival was evaluated by univariate and multivariate analyses.
  
  
  RESULTS
  Of 203 patients, 116 cases (57.1%) were positive for PEDF. A significant association was found between PEDF expression and high MVD (p = 0.012). PEDF expression was inversely correlated with grade (p = 0.004) and pT stage (p = 0.001). Multivariate analysis using the Cox regression model indicated that PEDF expression was an independent favorable prognostic factor (risk ratio, 4.105; p = 0.001). However, no significant correlation was found between PEDF expression and age, gender, tumor diameter or lymph node invasion.
  
  
  CONCLUSIONS
  Our findings suggest that PEDF may be a favorable prognostic indicator in patients with CCRCC.
authors.affiliation: Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Jiang
authors.forename: Zhujun
authors.initials: Z
authors.lastname: Fang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ding
mesh_terms: D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000378:metabolism* / Q000401:mortality; D005136:Eye Proteins / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000032:analysis / Q000096:biosynthesis*; D011379:Prognosis; D012189:Retrospective Studies; D015843:Serpins / Q000032:analysis / Q000096:biosynthesis*; D015996:Survival Rate; D000099174:Pigment Epithelium-Derived Factor
chemical_list: D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor