title: Evaluating tamoxifen effect in the prevention of hypertrophic scars following surgical incisions.
abstract: OBJECTIVE
  To evaluate the clinical utility of tamoxifen in the prevention of hypertrophic scars (HTSs).
  
  
  METHODS
  In a double-blind randomized clinical trial, 300 patients with a history of HTSs who underwent surgery with different skin incisions were assigned randomly to two groups. The first received tamoxifen tablets postoperatively according to a standard protocol, and the control group received placebo. After 2 months, the two groups were compared according to the development of HTSs, and the results were analyzed.
  
  
  RESULTS
  The studied population comprised 235 men (78.7%) and 65 women (21.7%) who developed HTSs after surgical incision, 138 of whom (92%) were in the study group and 78 (52%) in the control group.
  
  
  CONCLUSIONS
  Tamoxifen seems to be an effective agent in the prevention of HTSs after surgery.
authors.affiliation: Department of Surgery, Shahid Beheshti University of Medical Sciences, Shohada Tahrish Hospital, Tehran, Iran. seyed29@yahoo.com
authors.forename: Seyed Reza
authors.initials: SR
authors.lastname: Mousavi
authors.forename: Mohamad
authors.initials: M
authors.lastname: Raaiszadeh
authors.forename: Mohamad
authors.initials: M
authors.lastname: Aminseresht
authors.forename: Shahin
authors.initials: S
authors.lastname: Behjoo
mesh_terms: D000284:Administration, Oral; D017439:Cicatrix, Hypertrophic / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004965:Estrogen Antagonists / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011183:Postoperative Complications; D012189:Retrospective Studies; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013629:Tamoxifen / Q000008:administration & dosage*; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D004965:Estrogen Antagonists; D013629:Tamoxifen