title: Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia.
abstract: Inhibition of the P50 evoked electroencephalographic response to the second of paired auditory stimuli has been frequently examined as a neurophysiological deficit in schizophrenia. The Consortium on the Genetics of Schizophrenia (COGS), a 7-site study funded by the National Institute of Mental Health, examined this endophenotype in recordings from 181 probands with schizophrenia, 429 of their first degree relatives, and 333 community comparison control subjects. Most probands were treated with second generation antipsychotic medications. Highly significant differences in P50 inhibition, measured as either the ratio of amplitudes or their difference in response to the two stimuli, were found between the probands and the community comparison sample. There were no differences between the COGS sites for these findings. For the ratio parameter, an admixture analysis found that nearly 40% of the relatives demonstrated deficiencies in P50 inhibition that are comparable to the deficit found in the probands. These results indicate that P50 auditory evoked potentials can be recorded across multiple sites and reliably demonstrate a physiological abnormality in schizophrenia. The appearance of the physiological abnormality in a substantial proportion of clinically unaffected first degree relatives is consistent with the hypothesis that deficits in cerebral inhibition are a familial neurobiological risk factor for the illness.
authors.affiliation: Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA. Ann.olincy@ucdenver.edu
authors.forename: Ann
authors.initials: A
authors.lastname: Olincy
authors.forename: David L
authors.initials: DL
authors.lastname: Braff
authors.forename: Lawrence E
authors.initials: LE
authors.lastname: Adler
authors.forename: Kristin S
authors.initials: KS
authors.lastname: Cadenhead
authors.forename: Monica E
authors.initials: ME
authors.lastname: Calkins
authors.forename: Dorcas J
authors.initials: DJ
authors.lastname: Dobie
authors.forename: Michael F
authors.initials: MF
authors.lastname: Green
authors.forename: Tiffany A
authors.initials: TA
authors.lastname: Greenwood
authors.forename: Raquel E
authors.initials: RE
authors.lastname: Gur
authors.forename: Reuben C
authors.initials: RC
authors.lastname: Gur
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Light
authors.forename: James
authors.initials: J
authors.lastname: Mintz
authors.forename: Keith H
authors.initials: KH
authors.lastname: Nuechterlein
authors.forename: Allen D
authors.initials: AD
authors.lastname: Radant
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Schork
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Seidman
authors.forename: Larry J
authors.initials: LJ
authors.lastname: Siever
authors.forename: Jeremy M
authors.initials: JM
authors.lastname: Silverman
authors.forename: William S
authors.initials: WS
authors.lastname: Stone
authors.forename: Neal R
authors.initials: NR
authors.lastname: Swerdlow
authors.forename: Debby W
authors.initials: DW
authors.lastname: Tsuang
authors.forename: Ming T
authors.initials: MT
authors.lastname: Tsuang
authors.forename: Bruce I
authors.initials: BI
authors.lastname: Turetsky
authors.forename: Brandie D
authors.initials: BD
authors.lastname: Wagner
authors.forename: Robert
authors.initials: R
authors.lastname: Freedman
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000235:genetics* / Q000502:physiology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009433:Neural Inhibition / Q000235:genetics* / Q000502:physiology*; D010641:Phenotype; D012016:Reference Values; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology*
references.citation: Biol Psychiatry. 1982 Jun;17(6):639-54
references.pmid: 7104417
references.citation: Biol Psychiatry. 1991 Sep 1;30(5):430-42
references.pmid: 1932393
references.citation: Psychophysiology. 1995 Sep;32(5):460-6
references.pmid: 7568640
references.citation: J Neurophysiol. 1997 Oct;78(4):2156-63
references.pmid: 9325382
references.citation: Psychophysiology. 1994 Sep;31(5):495-502
references.pmid: 7972604
references.citation: Am J Psychiatry. 1998 Dec;155(12):1691-4
references.pmid: 9842777
references.citation: Brain Res. 1988 Feb 23;442(1):131-8
references.pmid: 2834010
references.citation: Arch Gen Psychiatry. 2007 Nov;64(11):1242-50
references.pmid: 17984393
references.citation: Behav Genet. 2006 Nov;36(6):845-57
references.pmid: 16826459
references.citation: Neuroscience. 1995 Nov;69(2):371-81
references.pmid: 8552235
references.citation: Am J Psychiatry. 2004 Oct;161(10):1822-8
references.pmid: 15465979
references.citation: Biol Psychiatry. 1989 Mar 1;25(5):549-61
references.pmid: 2920190
references.citation: Psychiatry Res. 1992 Oct;44(1):21-32
references.pmid: 1461944
references.citation: Psychiatry Res. 1990 Mar;31(3):297-309
references.pmid: 2333360
references.citation: Arch Gen Psychiatry. 2002 Dec;59(12):1085-96
references.pmid: 12470124
references.citation: Schizophr Res. 2004 Oct 1;70(2-3):315-29
references.pmid: 15329307
references.citation: Schizophr Bull. 2007 Jan;33(1):33-48
references.pmid: 17035358
references.citation: Psychophysiology. 2003 Jan;40(1):29-38
references.pmid: 12751801
references.citation: Biol Psychiatry. 2007 Oct 1;62(7):822-5
references.pmid: 17448448
references.citation: Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):587-92
references.pmid: 9012828
references.citation: Schizophr Res. 2007 Jan;89(1-3):312-9
references.pmid: 17014995
references.citation: Mol Psychiatry. 2004 Mar;9(3):320-2
references.pmid: 14569275
references.citation: Clin Neurophysiol. 2001 Jul;112(7):1154-65
references.pmid: 11516727
references.citation: Am J Psychiatry. 2000 May;157(5):767-71
references.pmid: 10784470
references.citation: Arch Gen Psychiatry. 1984 Jun;41(6):607-12
references.pmid: 6732421
references.citation: Clin Neurophysiol. 2006 Nov;117(11):2549-63
references.pmid: 17008125
references.citation: Psychiatry Res. 2008 Mar 15;158(2):226-47
references.pmid: 18187207
references.citation: Schizophr Res. 2007 Dec;97(1-3):137-51
references.pmid: 17604606
references.citation: Schizophr Res. 2009 Mar;108(1-3):151-7
references.pmid: 19106034
references.citation: Schizophr Res. 2007 May;92(1-3):262-72
references.pmid: 17336502