Evidence of a novel somatopic map in the human neocerebellum during complex actions.
The human neocerebellum has been hypothesized to contribute to many high-level cognitive processes including attention, language, and working memory. Support for these nonmotor hypotheses comes from evidence demonstrating structural and functional connectivity between the lateral cerebellum and cortical association areas as well as a lack of somatotopy in lobules VI and VII, a hallmark of motor representations in other areas of the cerebellum and cerebral cortex. We set out to test whether somatotopy exists in these lobules by using functional magnetic resonance imaging to measure cerebellar activity while participants produced simple or complex movements, using either fingers or toes. We observed a previously undiscovered somatotopic organization in neocerebellar lobules VI and VIIA that was most prominent when participants executed complex movements. In contrast, activation in the anterior lobe showed a similar somatotopic organization for both simple and complex movements. While the anterior somatotopic representation responded selectively during ipsilateral movements, the new cerebellar map responded during both ipsi- and contralateral movements. The presence of a bilateral, task-dependent somatotopic map in the neocerebellum emphasizes an important role for this region in the control of skilled actions.
Schlerf
J E
JE
Department of Psychology and Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA. rspencer@psych.umass.edu
Verstynen
T D
TD
Ivry
R B
RB
Spencer
R M C
RM
D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D002531:Cerebellum / Q000098:blood supply / Q000502:physiology*; D005260:Female; D005385:Fingers / Q000294:innervation; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D009044:Motor Cortex / Q000098:blood supply / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D009434:Neural Pathways / Q000098:blood supply / Q000502:physiology; D010100:Oxygen / Q000097:blood; D055815:Young Adult
D010100:Oxygen
J Neurophysiol. 2005 Mar;93(3):1209-22
15525809
Neuroimage. 2002 Apr;15(4):870-8
11906227
Ann Neurol. 2005 Oct;58(4):553-60
16178033
Hum Brain Mapp. 2001 Jun;13(2):55-73
11346886
Brain. 2006 Feb;129(Pt 2):290-2
16434422
Neuroimage. 2007 Jun;36(2):378-87
17459731
J Neurosci. 2005 Oct 26;25(43):9919-31
16251440
J Neurophysiol. 1999 Jan;81(1):383-7
9914297
Learn Mem. 1997 May-Jun;4(1):1-35
10456051
Ann N Y Acad Sci. 2002 Dec;978:289-301
12582061
Neuroimage. 2003 Mar;18(3):670-4
12667844
J Neurophysiol. 2004 Jul;92(1):523-35
14973321
Nat Rev Neurosci. 2004 Mar;5(3):241-9
14976523
Brain. 1996 Jun;119 ( Pt 3):1023-9
8673479
Conf Proc IEEE Eng Med Biol Soc. 2004;2004:4637-40
17271341
J Neurosci. 2002 Feb 15;22(4):1426-35
11850469
Neuroimage. 2006 May 1;30(4):1088-96; discussion 1097-9
16635578
J Neurosci. 1996 Jan 15;16(2):808-22
8551361
J Neurosci. 2003 Sep 10;23(23):8432-44
12968006
J Neurosci. 2001 Jan 15;21(2):700-12
11160449
Neuroreport. 1999 Nov 26;10(17):3653-8
10619661
Brain. 2006 Feb;129(Pt 2):306-20
16317024
Neuroimage. 2009 May 15;46(1):39-46
19457380
Trends Neurosci. 2007 Jun;30(6):251-9
17462748
J Neurophysiol. 2005 May;93(5):2950-8
15625099
Neuroimage. 1998 May;7(4 Pt 1):368-76
9626676
Neuroimage. 2009 Jan 15;44(2):489-501
18835452
J Neurosci. 1998 Dec 1;18(23):10105-15
9822764
Behav Neurosci. 1992 Oct;106(5):731-8
1445653
J Physiol. 2006 Mar 15;571(Pt 3):619-37
16423861
Exp Brain Res. 2008 Jun;188(2):223-36
18369608
Neuroreport. 2004 Mar 22;15(4):595-9
15094459
J Neurophysiol. 2004 Jan;91(1):576-82
12878717
Cereb Cortex. 2009 Oct;19(10):2485-97
19592571
Annu Rev Neurosci. 2009;32:413-34
19555291
Neuroimage. 2006 Oct 15;33(1):127-38
16904911
Annu Rev Neurosci. 1992;15:403-42
1575449
Neuroreport. 2004 Jul 19;15(10):1571-4
15232285