Tea, coffee, carbonated soft drinks and upper gastrointestinal tract cancer risk in a large United States prospective cohort study.
The authors investigated the relationship between hot tea, iced tea, coffee and carbonated soft drinks consumption and upper gastrointestinal tract cancers risk in the NIH-AARP Study. During 2,584,953 person-years of follow-up on 481,563 subjects, 392 oral cavity, 178 pharynx, 307 larynx, 231 gastric cardia, 224 gastric non-cardia cancer, 123 Oesophageal Squamous Cell Carcinoma (ESCC) and 305 Oesophageal Adenocarcinoma (EADC) cases were accrued. Hazard ratios (HRs) and 95% confidence intervals (95% CIs) were calculated by multivariate-adjusted Cox regression. Compared to non-drinking, the hazard ratio for hot tea intake of > or =1 cup/day was 0.37 (95% CI: 0.20, 0.70) for pharyngeal cancer. The authors also observed a significant association between coffee drinking and risk of gastric cardia cancer (compared to <1 cup/day, the hazard ratio for drinking >3 cups/day was 1.57 (95% CI: 1.03, 2.39)), and an inverse association between coffee drinking and EADC for the cases occurring in the last 3 years of follow-up (compared to <1 cup/day, the hazard ratio for drinking >3 cups/day was 0.54 (95% CI: 0.31, 0.92)), but no association in earlier follow-up. In summary, hot tea intake was inversely associated with pharyngeal cancer, and coffee was directly associated with gastric cardia cancer, but was inversely associated with EADC during some follow-up periods.
Ren
J S
JS
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States.
Freedman
N D
ND
Kamangar
F
F
Dawsey
S M
SM
Hollenbeck
A R
AR
Schatzkin
A
A
Abnet
C C
CC
D000368:Aged; D002253:Carbonated Beverages / Q000009:adverse effects*; D003069:Coffee / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D005770:Gastrointestinal Neoplasms / Q000453:epidemiology / Q000209:etiology*; D006358:Hot Temperature / Q000009:adverse effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D013662:Tea / Q000009:adverse effects*; D014481:United States / Q000453:epidemiology
D003069:Coffee; D013662:Tea
Cancer Causes Control. 1995 Jan;6(1):57-67
7718736
Chin Med. 2008 Oct 22;3:12
18940008
Anticancer Agents Med Chem. 2006 Sep;6(5):389-406
17017850
Int J Cancer. 2000 Nov 15;88(4):658-64
11058886
BMJ. 2009 Mar 26;338:b929
19325180
J Natl Cancer Inst. 1986 May;76(5):823-31
3457969
Epidemiology. 1994 Nov;5(6):583-90
7841239
Cancer Causes Control. 1994 Sep;5(5):401-8
7999961
Nutr Cancer. 1984;6(4):220-8
6545578
Am J Epidemiol. 2001 Dec 15;154(12):1119-25
11744517
Cancer Causes Control. 2008 Aug;19(6):577-84
18231869
Ann Epidemiol. 2007 Oct;17(10):821-6
17606381
J Natl Cancer Inst. 1994 Jun 1;86(11):855-8
8182766
Int J Cancer. 2000 Jul 15;87(2):289-94
10861489
J Natl Cancer Inst. 2006 Aug 16;98(16):1158-61
16912268
Eur J Gastroenterol Hepatol. 2007 Feb;19(2):171-6
17273005
Asian Pac J Cancer Prev. 2005 Apr-Jun;6(2):202-7
16101334
J Natl Cancer Inst. 2006 Jan 4;98(1):72-5
16391374
Aliment Pharmacol Ther. 2004 Mar 1;19(5):497-510
14987318
Am J Epidemiol. 2008 Dec 15;168(12):1425-32
18974083
Nutr Cancer. 1987;10(1-2):103-13
3112746
Oral Oncol. 2004 Feb;40(2):207-13
14693246
J Epidemiol. 2006 Sep;16(5):185-92
16951537
Cancer Causes Control. 1998 Mar;9(2):209-16
9578298
Zhonghua Liu Xing Bing Xue Za Zhi. 2003 Mar;24(3):192-5
12816709
Br J Cancer. 1999 May;80(3-4):614-20
10408875
Cad Saude Publica. 2006 May;22(5):889-900
16680342
Gan To Kagaku Ryoho. 2002 Feb;29 Suppl 1:159-72
11890101
Int J Cancer. 2009 Feb 1;124(3):670-7
18973231
Nutr Cancer. 1992;17(1):27-31
1574442
Cancer. 1993 Aug 15;72(4):1369-75
8339227
Oral Oncol. 2003 Oct;39(7):695-700
12907209
CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108
15761078
Nutr Cancer. 2000;38(2):186-91
11525596
Int J Cancer. 2009 Aug 1;125(3):491-524
19415743
Br J Cancer. 2002 Feb 1;86(3):346-7
11875696
J Laryngol Otol. 2002 Jul;116(7):523-31
12238672
J Food Prot. 2001 Aug;64(8):1268-70
11510675
Cancer Res. 1989 Feb 15;49(4):1049-51
2912550
Asia Pac J Clin Nutr. 2008;17 Suppl 1:245-8
18296347
Asian Pac J Cancer Prev. 2004 Jan-Mar;5(1):58-65
15075007
Arh Hig Rada Toksikol. 2008 Mar;59(1):11-8
18407867
J Agric Food Chem. 2004 Dec 29;52(26):8268-71
15612828
Cancer Causes Control. 2009 Oct;20(8):1303-8
19430969