Metallo-organic G-quadruplex ligands in anticancer drug design.
Guanine-rich DNA sequences can form planar four-stranded structures via Hoogsteen hydrogen bonds. These sequences in telomeric DNA and some oncogenes have been identified as targets for novel anticancer drugs. Consequently, there is great current interest in developing small molecules that can facilitate the formation of, and stabilize G-quadruplexes as potent antitumor chemotherapeutic agents. Metal complexes with planar geometries and phi-delocalised ligands are emerging as a new class of quadruplex DNA ligand with unique features for optimal binding. This review will summarize the different types of metal-based compounds that target G-quadruplexes and provide useful information on the design of small ligands.
Jiang
Y-L
YL
Department of Organic Chemistry, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, PR China.
Liu
Z-P
ZP
D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D056831:Coordination Complexes / Q000737:chemistry* / Q000627:therapeutic use; D015195:Drug Design; D054856:G-Quadruplexes; D006801:Humans; D008024:Ligands; D009369:Neoplasms / Q000188:drug therapy; D010618:Phenanthrolines / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry
D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D010618:Phenanthrolines; D011725:Pyridines