title: Chromeno[2,3-d]pyrimidine-triones synthesis by a three-component coupling reaction.
abstract: A simple and one-pot synthesis of new chromeno[2,3-d]pyrimidine-triones by a three-component condensation reaction of barbituric acids, aldehydes and cyclohexane-1,3-diones in refluxing ethanol in the presence of p-toluenesulfonic acid (p-TSA) for 3-10 h is reported. Two cyclohexane-1,3-diones, four barbituric acids and six substituted aldehydes were chosen for the library validation. Prominent among the advantages of this new method are operational simplicity, good yields and easy work-up procedures employed.
authors.affiliation: Department of Chemistry, Shahid Beheshti University, Tehran, Iran.
authors.forename: Ramin
authors.initials: R
authors.lastname: Ghahremanzadeh
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Fereshtehnejad
authors.forename: Ayoob
authors.initials: A
authors.lastname: Bazgir
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D001463:Barbiturates / Q000737:chemistry; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques / Q000191:economics / Q000379:methods*; D003512:Cyclohexanones / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000447:Aldehydes; D001463:Barbiturates; D001578:Benzopyrans; D003512:Cyclohexanones; D011743:Pyrimidines; C004636:1,3-cyclohexanedione; C030986:pyrimidine; C032232:barbituric acid