title: Predictive value of subclinical autistic traits at age 14-15 months for behavioural and cognitive problems at age 3-5 years.
abstract: It is unclear whether subclinical autistic traits at very young age are transient or stable, and have clinical relevance. This study investigated the relationship between early subclinical autistic traits and the occurrence of later developmental and behavioural problems as well as problems in cognitive and language functioning. Parents of infants aged 14-15 months from the general population completed the Early Screening of Autistic Traits Questionnaire (ESAT). Three groups of children with high, moderate, and low ESAT-scores (total n = 103) were selected. Follow-up assessments included the CBCL 1(1/2)-5 at age 3 years, and the SCQ, the ADI-R, the ADOS-G, an on-verbal intelligence test, and language tests for comprehension and production at age 4-5 years. None of the children met criteria for autism spectrum disorder at follow-up. Children with high ESAT-scores at 14-15 months showed significantly more internalizing and externalizing problems at age 3 years and scored significantly lower on language tests at age 4-5 years than children with moderate or low ESAT-scores. Further, significantly more children with high ESAT-scores (14/26, 53.8%) than with moderate and low ESAT-scores (5/36, 13.9% and 1/41, 2.4%, respectively) were in the high-risk/clinical range on one or more outcome domains (autistic symptoms, behavioural problems, cognitive and language abilities). Subclinical autistic traits at 14-15 months predict later behavioural problems and delays in cognitive and language functioning rather than later ASD-diagnoses. The theoretical implications of the findings lie in the pivotal role of early social and communication skills for the development of self-regulation of emotions and impulses. The practical implications bear on the early recognition of children at risk for behavioural problems and for language and cognitive problems.
authors.affiliation: Department of Psychiatry (966), Nijmegen Centre for Evidence-Based Practice (NCEBP), Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Esmé
authors.initials: E
authors.lastname: Möricke
authors.forename: Sophie H N
authors.initials: SH
authors.lastname: Swinkels
authors.forename: Karin T
authors.initials: KT
authors.lastname: Beuker
authors.forename: Jan K
authors.initials: JK
authors.lastname: Buitelaar
mesh_terms: D002653:Child Behavior Disorders / Q000145:classification / Q000175:diagnosis* / Q000523:psychology; D002659:Child Development Disorders, Pervasive / Q000145:classification / Q000175:diagnosis* / Q000523:psychology; D002675:Child, Preschool; D003072:Cognition Disorders / Q000145:classification / Q000175:diagnosis* / Q000523:psychology; D042241:Early Diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007389:Internal-External Control; D007805:Language Development Disorders / Q000145:classification / Q000175:diagnosis / Q000523:psychology; D008403:Mass Screening; D009426:Netherlands; D010552:Personality Assessment / Q000706:statistics & numerical data; D011594:Psychometrics; D015203:Reproducibility of Results
references.citation: J Atten Disord. 2009 Sep;13(2):117-26
references.pmid: 19380514
references.citation: J Autism Dev Disord. 2000 Jun;30(3):205-23
references.pmid: 11055457
references.citation: Autism. 2006 Mar;10(2):199-220
references.pmid: 16613868
references.citation: Clin Child Fam Psychol Rev. 2005 Dec;8(4):271-89
references.pmid: 16362256
references.citation: J Am Acad Nurse Pract. 2007 Aug;19(8):408-17
references.pmid: 17655570
references.citation: J Am Acad Child Adolesc Psychiatry. 2008 Aug;47(8):921-9
references.pmid: 18645422
references.citation: J Autism Dev Disord. 2006 Nov;36(8):993-1005
references.pmid: 16845578
references.citation: J Abnorm Child Psychol. 1998 Dec;26(6):441-52
references.pmid: 9915651
references.citation: J Autism Dev Disord. 2008 Apr;38(4):606-15
references.pmid: 17924183
references.citation: J Am Acad Child Adolesc Psychiatry. 2004 Feb;43(2):172-80
references.pmid: 14726723
references.citation: J Autism Dev Disord. 2006 Aug;36(6):713-22
references.pmid: 16633887
references.citation: J Autism Dev Disord. 1994 Oct;24(5):659-85
references.pmid: 7814313
references.citation: Lang Speech Hear Serv Sch. 2003 Jul 1;34(3):180-193
references.pmid: 27764320
references.citation: J Dev Behav Pediatr. 2006 Apr;27(2 Suppl):S95-S103
references.pmid: 16685191
references.citation: Nat Clin Pract Neurol. 2008 Mar;4(3):138-47
references.pmid: 18253102
references.citation: Psychiatr Clin North Am. 2002 Dec;25(4):811-36
references.pmid: 12462862
references.citation: J Psychiatr Pract. 2003 Mar;9(2):111-27
references.pmid: 15985922
references.citation: J Autism Dev Disord. 2008 Sep;38(8):1426-38
references.pmid: 18188685
references.citation: J Autism Dev Disord. 2006 Aug;36(6):723-32
references.pmid: 16614790
references.citation: Clin Psychol Rev. 2008 Apr;28(4):692-708
references.pmid: 18036711
references.citation: J Am Acad Child Adolesc Psychiatry. 1997 Feb;36(2):165-78
references.pmid: 9031569
references.citation: J Am Acad Child Adolesc Psychiatry. 2007 Oct;46(10):1324-1332
references.pmid: 17885574
references.citation: Ment Retard Dev Disabil Res Rev. 2004;10(2):106-11
references.pmid: 15362165
references.citation: Am J Speech Lang Pathol. 2003 Aug;12(3):349-58
references.pmid: 12971823
references.citation: Semin Pediatr Neurol. 2004 Sep;11(3):205-13
references.pmid: 15575415
references.citation: J Child Psychol Psychiatry. 2006 Mar-Apr;47(3-4):395-422
references.pmid: 16492265
references.citation: J Autism Dev Disord. 2006 Nov;36(8):1065-76
references.pmid: 16865549
references.citation: Eur Child Adolesc Psychiatry. 2007 Jun;16(4):271-80
references.pmid: 17417714
references.citation: J Autism Dev Disord. 2007 Oct;37(9):1721-34
references.pmid: 17180717
references.citation: J Child Psychol Psychiatry. 2007 Sep;48(9):932-40
references.pmid: 17714378
references.citation: J Autism Dev Disord. 2004 Aug;34(4):379-93
references.pmid: 15449514
references.citation: Br J Psychiatry. 1999 Nov;175:444-51
references.pmid: 10789276
references.citation: Can J Psychiatry. 2003 Sep;48(8):506-16
references.pmid: 14574826
references.citation: J Autism Dev Disord. 2007 Aug;37(7):1272-8
references.pmid: 17080270