Synthesis and Pharmacological Evaluation of (6-Substituted 4-Oxo-4H-chromene-3 yl) methyl N-substituted Aminoacetates.
A series of the title compounds were synthesized and characterized by spectral data. All the compounds were evaluated for in vitro antihistaminic activity by inhibition of isotonic contractions induced by histamine on isolated guinea pig ileum and the compound 6-k showed significant activity. A few compounds have also been screened for in vivo bronchodilatory activity. These compounds exhibited significant protection against histamine-induced convulsions in guinea pig at the dose of 50 mumol.
Gajbhiye
Asmita
A
Medicinal Chemistry Research Lab, University College of Pharmaceutical Sciences, Kakatiya University, Warangal - 506 009, India.
Mallareddy
V
V
Achaiah
G
G
Chem Pharm Bull (Tokyo). 1974 Dec;22(12):2959-65
4468116
J Med Chem. 1996 Jul 19;39(15):2962-70
8709130
J Med Chem. 1998 Dec 31;41(27):5402-9
9876110