title: Cyclin B-Cdk1 activates its own pump to get into the nucleus.
abstract: The transition to mitosis requires extensive nuclear and cytoplasmic rearrangements that must be spatially and temporally coordinated. In this issue, Gavet and Pines (2010a. J. Cell Biol. doi:10.1083/jcb.200909144) report on a simple yet elegant mechanism as to how this is achieved. By monitoring the activity of cyclin B-Cdk1 in real time, the authors show that concomitant with its activation in the cytoplasm, the kinase complex is rapidly imported into the nucleus by modifying the activity of the nucleocytoplasmic transport machinery. Thus, cyclin B-Cdk1 activates its own pump to get into the nucleus.
authors.affiliation: Department of Medical Oncology, University Medical Center Utrecht, 3584CG Utrecht, Netherlands. a.lindqvist@umcutrecht.nl
authors.forename: Arne
authors.initials: A
authors.lastname: Lindqvist
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000502:physiology*; D016203:CDC2 Protein Kinase / Q000235:genetics / Q000378:metabolism*; D002453:Cell Cycle / Q000502:physiology; D002467:Cell Nucleus / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism; D019926:Cyclin B / Q000235:genetics / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D004789:Enzyme Activation
chemical_list: D002843:Chromatin; D019926:Cyclin B; D016203:CDC2 Protein Kinase
references.citation: PLoS Biol. 2007 May;5(5):e123
references.pmid: 17472438
references.citation: J Cell Biol. 2004 Mar 29;164(7):965-71
references.pmid: 15037602
references.citation: Nat Cell Biol. 2003 Feb;5(2):143-8
references.pmid: 12524548
references.citation: Proc Natl Acad Sci U S A. 1997 Jan 21;94(2):502-7
references.pmid: 9012813
references.citation: J Exp Zool. 1971 Jun;177(2):129-45
references.pmid: 5106340
references.citation: Curr Biol. 1999 Jul 1;9(13):680-9
references.pmid: 10395539
references.citation: Cell. 1990 Nov 30;63(5):1013-24
references.pmid: 2147872
references.citation: Genes Dev. 2004 Mar 1;18(5):512-27
references.pmid: 15014043
references.citation: Dev Cell. 2010 Apr 20;18(4):533-43
references.pmid: 20412769
references.citation: Oncogene. 2002 Nov 28;21(54):8282-92
references.pmid: 12447691
references.citation: Trends Genet. 1996 Sep;12(9):345-50
references.pmid: 8855663
references.citation: Nature. 2001 Mar 8;410(6825):215-20
references.pmid: 11242082
references.citation: J Cell Biol. 2010 Apr 19;189(2):247-59
references.pmid: 20404109