Effect of a controlled release device containing minocycline microspheres on the treatment of chronic periodontitis: A comparative study.
BACKGROUND
Adjunctive therapy with locally delivered antimicrobials has resulted in improved clinical outcomes. The aim of this study was to evaluate the efficacy and safety of locally administered minocycline microspheres (Arestin) in the treatment of chronic periodontitis.


METHODS
A total of 60 sites from 15 patients in the age group of 35-50 years, who had periodontal pockets measuring 5-8 mm and had been diagnosed with chronic periodontitis, were selected for the study. The selected groups were randomly assigned to either the control group (group A) or the treatment/test group (group B). Only scaling and root planing were done at the base line visit for the control sites followed by local application of Arestin (1 mg). Clinical parameters such as plaque index, gingival index, and gingival bleeding index were recorded at baseline, day 30, day 90, and day 180 in the selected sites of both the groups. Probing pocket depth also was recorded at baseline, day 90, and day 180 for both the groups.


RESULTS
A statistically significant reduction was observed in both groups. Group B showed better results than Group A and these differences were statistically significant.


CONCLUSIONS
The results of this study clearly indicate that treatment with scaling and root planing plus minocycline microspheres (Arestin) is more effective and safer than scaling and root planing alone in reducing the signs of chronic periodontitis.
Gopinath
V
V
Senior Lecturer, Department of Periodontics, Saveetha Dental College and Hospital, Poonamalee High Road, Velapanchavadi, Chennai - 77, India.
Ramakrishnan
T
T
Emmadi
Pamela
P
Ambalavanan
N
N
Mammen
Biju
B
Vijayalakshmi
J Periodontol. 1990 Sep;61(9):579-84
2213468
J Periodontal Res. 1987 May;22(3):217-21
2955102
Compend Contin Educ Dent. 2003 Feb;24(2):121-6, 128, 130 passim; quiz 133
12723407
J Periodontol. 1993 Jul;64(7):637-44
8396177
Nihon Shishubyo Gakkai Kaishi. 1988 Mar;30(1):182-90
3254384
J Clin Periodontol. 1993 Aug;20(7):498-504
8354724
J Periodontol. 1998 Jan;69(1):92-9
9527568
J Periodontol. 1998 May;69(5):507-20
9623893
J Periodontol. 1994 Nov;65(11):1058-66
7853130
Compend Contin Educ Dent. 2003 Apr;24(4):247-50, 252-7; quiz 258
12769027
J Periodontol. 1999 Jan;70(1):1-7
10052765
J Periodontol. 1996 Apr;67(4):422-7
8708969
J Periodontol. 1997 Nov;68(11):1102-9
9407404
J Periodontol. 1993 Jun;64(6):509-19
8336251
J Periodontol. 1988 May;59(5):306-10
3290431
J Clin Periodontol. 1996 Aug;23(8):707-16
8877655
J Periodontol. 1996 Sep;67(9):860-5
8884642
J Periodontol. 1994 Sep;65(9):835-9
7990019
J Periodontol. 1996 Jul;67(7):682-7
8832479
J Periodontol. 1999 Jun;70(6):657-67
10397521
J Periodontol. 2001 Nov;72(11):1535-44
11759865