Neuroprotective effect of lipoxin A4 methyl ester in a rat model of permanent focal cerebral ischemia.
Neuroprotective effect of lipoxin A(4) methyl ester (LXA(4) ME) was tested in a rat model of permanent middle cerebral artery occlusion. LXA(4) ME was administrated through intracerebroventricular injection immediately after middle cerebral artery was occluded. Administration of LXA(4) ME ameliorated neurological deficit, reduced infarct volume, attenuated histological damage, and decreased number of apoptotic neuron induced by ischemic insult. These neuroprotective effects of LXA(4) ME were associated with inhibition of neutrophil infiltration, lipid peroxidation, and astrocyte activation. In addition, LXA(4) ME also attenuated proinflammatory cytokines (TNF-alpha and IL-1beta) production. These data suggest that LXA(4) ME protects neuron against permanent cerebral ischemia by inhibiting inflammatory responses.
Wu
Yan
Y
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ye
Xi-Hong
XH
Guo
Pei-Pei
PP
Xu
San-Peng
SP
Wang
Jie
J
Yuan
Shi-Ying
SY
Yao
Shang-Long
SL
Shang
You
Y
D000818:Animals; D001253:Astrocytes / Q000187:drug effects; D002545:Brain Ischemia / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D002544:Cerebral Infarction / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D004660:Encephalitis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D004952:Esters / Q000494:pharmacology*; D007276:Injections, Intraventricular; D015227:Lipid Peroxidation / Q000187:drug effects; D044045:Lipoxins / Q000008:administration & dosage*; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D009504:Neutrophils / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000187:drug effects
D004952:Esters; D044045:Lipoxins; D018696:Neuroprotective Agents; C040527:lipoxin A4
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