Development of a molecularly imprinted polymer for selective extraction of bisphenol A in water samples.
A cross-linked methacrylate molecularly imprinted polymer (poly-4-vinylpyridine-co-trimethylolpropane-trimethacrylate) selective for bisphenol A (BPA) was synthesized, using a fluorinated BPA derivative (4,4'-(hexafluoroisopropylidene)-diphenol) as a mimic template, and applied to the analysis of real-world samples of process and potable waters. The molecularly imprinted polymer also showed a high affinity and selectivity for 17-beta-estradiol and ethynylestradiol. A method to analyze BPA, 17-beta-estradiol, and ethynylestradiol at ultratrace levels was thus developed from a screening procedure to monitor endocrine-disrupting chemicals in water samples. The method consists of the BPA-selective cleanup by molecularly imprinted SPE using cartridges packed with the polymer developed, its recovery by stir bar sorptive extraction after ad hoc derivatization to obtain the corresponding BPA-acetate, and its analysis by GC-time window-SIM-MS after online thermal desorption. The method showed good linearity in the working range (R(2)=0.9969), high repeatability (RSD% <10.1), recoveries always above 90%, and very low LOD (10 pg/L) and LOQ (1 ng/L) and can easily be extended to the determination of 17-beta-estradiol and ethynylestradiol ultratraces. The method's effectiveness was evaluated by analyzing the real-world water samples; it enabled preconcentration and detection of BPA at ultratrace levels.
Canale
Francesca
F
Dipartimento di Scienza e Tecnologia del Farmaco, Torino, Italy.
Cordero
Chiara
C
Baggiani
Claudio
C
Baravalle
Patrizia
P
Giovannoli
Cristina
C
Bicchi
Carlo
C
D000042:Absorption; D001559:Benzhydryl Compounds; D002621:Chemistry / Q000379:methods; D002623:Chemistry Techniques, Analytical; D002849:Chromatography, Gas / Q000379:methods; D003432:Cross-Linking Reagents / Q000737:chemistry; D004784:Environmental Monitoring / Q000379:methods; D004958:Estradiol / Q000737:chemistry; D004997:Ethinyl Estradiol / Q000737:chemistry; D007700:Kinetics; D008689:Methacrylates / Q000737:chemistry; D010636:Phenols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D015203:Reproducibility of Results; D014867:Water / Q000737:chemistry; D014874:Water Pollutants, Chemical / Q000032:analysis*; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D003432:Cross-Linking Reagents; D004958:Estradiol; D004997:Ethinyl Estradiol; D008689:Methacrylates; D010636:Phenols; D011108:Polymers; D014867:Water; D014874:Water Pollutants, Chemical; C006780:bisphenol A; D000098826:Bisphenol A Compounds