title: Genome-wide association of anthropometric traits in African- and African-derived populations.
abstract: Genome-wide association (GWA) studies have identified common variants that are associated with a variety of traits and diseases, but most studies have been performed in European-derived populations. Here, we describe the first genome-wide analyses of imputed genotype and copy number variants (CNVs) for anthropometric measures in African-derived populations: 1188 Nigerians from Igbo-Ora and Ibadan, Nigeria, and 743 African-Americans from Maywood, IL. To improve the reach of our study, we used imputation to estimate genotypes at approximately 2.1 million single-nucleotide polymorphisms (SNPs) and also tested CNVs for association. No SNPs or common CNVs reached a genome-wide significance level for association with height or body mass index (BMI), and the best signals from a meta-analysis of the two cohorts did not replicate in approximately 3700 African-Americans and Jamaicans. However, several loci previously confirmed in European populations showed evidence of replication in our GWA panel of African-derived populations, including variants near IHH and DLEU7 for height and MC4R for BMI. Analysis of global burden of rare CNVs suggested that lean individuals possess greater total burden of CNVs, but this finding was not supported in an independent European population. Our results suggest that there are not multiple loci with strong effects on anthropometric traits in African-derived populations and that sample sizes comparable to those needed in European GWA studies will be required to identify replicable associations. Meta-analysis of this data set with additional studies in African-ancestry populations will be helpful to improve power to detect novel associations.
authors.affiliation: Department of Biostatistics and Epidemiology, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Sun J
authors.initials: SJ
authors.lastname: Kang
authors.forename: Charleston W K
authors.initials: CW
authors.lastname: Chiang
authors.forename: Cameron D
authors.initials: CD
authors.lastname: Palmer
authors.forename: Bamidele O
authors.initials: BO
authors.lastname: Tayo
authors.forename: Guillaume
authors.initials: G
authors.lastname: Lettre
authors.forename: Johannah L
authors.initials: JL
authors.lastname: Butler
authors.forename: Rachel
authors.initials: R
authors.lastname: Hackett
authors.forename: Adebowale A
authors.initials: AA
authors.lastname: Adeyemo
authors.forename: Candace
authors.initials: C
authors.lastname: Guiducci
authors.forename: Ilze
authors.initials: I
authors.lastname: Berzins
authors.forename: Thutrang T
authors.initials: TT
authors.lastname: Nguyen
authors.forename: Tao
authors.initials: T
authors.lastname: Feng
authors.forename: Amy
authors.initials: A
authors.lastname: Luke
authors.forename: Daniel
authors.initials: D
authors.lastname: Shriner
authors.forename: Kristin
authors.initials: K
authors.lastname: Ardlie
authors.forename: Charles
authors.initials: C
authors.lastname: Rotimi
authors.forename: Rainford
authors.initials: R
authors.lastname: Wilks
authors.forename: Terrence
authors.initials: T
authors.lastname: Forrester
authors.forename: Colin A
authors.initials: CA
authors.lastname: McKenzie
authors.forename: Helen N
authors.initials: HN
authors.lastname: Lyon
authors.forename: Richard S
authors.initials: RS
authors.lastname: Cooper
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Zhu
authors.forename: Joel N
authors.initials: JN
authors.lastname: Hirschhorn
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American / Q000235:genetics*; D000368:Aged; D000886:Anthropometry; D044383:Black People / Q000235:genetics*; D056915:DNA Copy Number Variations; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007087:Illinois; D007563:Jamaica; D008875:Middle Aged; D015233:Models, Statistical; D009549:Nigeria; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
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