title: Neonatal tracheal changes following in utero fetoscopic balloon tracheal occlusion in severe congenital diaphragmatic hernia.
abstract: OBJECTIVE
  To report postnatal tracheal changes after in utero fetoscopic balloon tracheal occlusion in severe congenital diaphragmatic hernia (CDH).
  
  
  METHODS
  Case series.
  
  
  METHODS
  Tertiary care center, CDH National Reference Center.
  
  
  METHODS
  Seven consecutive newborn infants with severe CDH who underwent fetoscopic balloon tracheal occlusion.
  
  
  METHODS
  Flexible laryngotracheoscopy and histological aspect observed at necropsy in 2 nonsurvivors.
  
  
  RESULTS
  All infants displayed elongation and relaxation of the posterior tracheal wall, intermittently obstructing the lumen during tidal breathing. Whereas the cartilage displayed adequate rigidity, the pars membranacea appeared both flaccid and loose. Tracheal widening (tracheomegaly) was seen in all cases. Histology (n = 2) pointed to structural modifications throughout the pars membranacea, that is, loss of epithelial folding and of longitudinal elastic network and focal muscular disruption. The cartilage displayed no visible or histologic changes. The above tracheal changes were not symptomatic, except for a barking cough during increased respiratory efforts.
  
  
  CONCLUSIONS
  Tracheal widening and intermittent collapse of the posterior wall of the trachea during tidal breathing was found in 7 consecutive newborns who underwent fetoscopic balloon tracheal occlusion, causing mild clinical symptoms. Endoscopic tracheal assessment might provide useful information in children with CDH, in particular, when they underwent in utero fetoscopic balloon tracheal occlusion.
authors.affiliation: Department of Pediatric Otorhinolaryngology, Jeanne de Flandre Hospital, CHRU de Lille, France. p-fayoux@chru-lille.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Fayoux
authors.forename: Gregory
authors.initials: G
authors.lastname: Hosana
authors.forename: Louise
authors.initials: L
authors.lastname: Devisme
authors.forename: Jan
authors.initials: J
authors.lastname: Deprest
authors.forename: Jacques
authors.initials: J
authors.lastname: Jani
authors.forename: Pascal
authors.initials: P
authors.lastname: Vaast
authors.forename: Laurent
authors.initials: L
authors.lastname: Storme
mesh_terms: D021721:Balloon Occlusion / Q000009:adverse effects*; D005260:Female; D005315:Fetal Diseases / Q000628:therapy*; D005332:Fetoscopy; D006548:Hernia, Diaphragmatic / Q000628:therapy*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D014132:Trachea / Q000293:injuries* / Q000473:pathology / Q000648:ultrastructure; D016896:Treatment Outcome