title: A preliminary study of aquaporin 1 immunolocalization in chronic subdural hematoma membranes.
abstract: Aquaporin 1 (AQP1) is a molecular water channel expressed in many anatomical locations, particularly in epithelial barriers specialized in water transport. The aim of this study was to investigate AQP1 expression in chronic subdural hematoma (CSDH) membranes. In this preliminary study, 11 patients with CSDH underwent burr hole craniectomy and drainage. Membrane specimens were stained with a monoclonal antibody targeting AQP1 for immunohistochemical analysis. The endothelial cells of the sinusoid capillaries of the outer membranes exhibited an elevated immunoreactivity to AQP1 antibody compared to the staining intensity of specimens from the inner membrane and normal dura. These findings suggest that the outer membrane might be the source of the increased fluid accumulation responsible for chronic hematoma enlargement.
authors.affiliation: Department of Neurosurgery, Treviso Regional Hospital Ca'Foncello, University of Padova, Pzza. le Ospedale Civile No. 1, Treviso, Italy. luca.basaldella@mac.com
authors.forename: Luca
authors.initials: L
authors.lastname: Basaldella
authors.forename: Alessandro
authors.initials: A
authors.lastname: Perin
authors.forename: Enrico
authors.initials: E
authors.lastname: Orvieto
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Marton
authors.forename: David
authors.initials: D
authors.lastname: Itskevich
authors.forename: Angelo Paolo
authors.initials: AP
authors.lastname: Dei Tos
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Longatti
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D051398:Aquaporin 1 / Q000276:immunology / Q000378:metabolism*; D003399:Craniotomy / Q000379:methods; D004388:Dura Mater / Q000276:immunology / Q000378:metabolism* / Q000473:pathology; D004730:Endothelium, Vascular / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D045604:Extracellular Fluid / Q000276:immunology / Q000378:metabolism; D020200:Hematoma, Subdural, Chronic / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D026901:Membrane Transport Proteins / Q000276:immunology / Q000378:metabolism; D021381:Protein Transport / Q000276:immunology; D013355:Subdural Space / Q000276:immunology / Q000378:metabolism / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D026901:Membrane Transport Proteins; D051398:Aquaporin 1