title: Changes of some amino acid concentrations in the medial vestibular nucleus of conscious rats following acute hypotension.
abstract: Microdialysis and high performance liquid chromatography (HPLC) were used to measure the changes of certain amino acids in the medial vestibular nucleus (MVN) of conscious rats in order to understand whether those amino acids are involved in the regulation of blood pressure. Acute hypotension was induced by infusing sodium nitroprusside (SNP) into the femoral vein. In the control group, glutamate (Glu) release increased, though gamma-aminobutyric acid (GABA) and taurine (Tau) release decreased in the MVN following acute hypotension. In the unilateral labyrinthectomy group, the levels of Glu, GABA, and Tau were unchanged in the ipsilateral MVN to the lesion following acute hypotension. Furthermore, in the contralateral MVN to the lesion, Glu release increased, and GABA and Tau release decreased following acute hypotension. These results suggest that SNP-induced acute hypotension can influence the activity of neurons in the MVN through afferent signals from peripheral vestibular receptors, and that certain amino acid transmitters in the MVN are involved in this process.
authors.affiliation: Department of Physiology and Pathophysiology, Yanbian University College of Basic Medicine and Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules (Yanbian University), Ministry of Education, 1829 Juzi Road, Yanji 133000, Jilin Province, China.
authors.forename: Xiang-Lan
authors.initials: XL
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: An
authors.forename: Qing-Hua
authors.initials: QH
authors.lastname: Jin
authors.forename: Min Sun
authors.initials: MS
authors.lastname: Kim
authors.forename: Byung Rim
authors.initials: BR
authors.lastname: Park
authors.forename: Yuan-Zhe
authors.initials: YZ
authors.lastname: Jin
mesh_terms: D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure; D002851:Chromatography, High Pressure Liquid; D018698:Glutamic Acid / Q000378:metabolism*; D007022:Hypotension / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D017551:Microdialysis; D051381:Rats; D013654:Taurine / Q000378:metabolism*; D014726:Vestibular Nuclei / Q000378:metabolism* / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
chemical_list: D013654:Taurine; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid