title: Regulation of membrane biogenesis in autophagy via PI3P dynamics.
abstract: In autophagy, cytoplasmic substrates are targeted for degradation in the lysosome via membrane structures called autophagosomes. The formation of the autophagosome is the primary regulatory point for autophagy activity, and PI3P plays a central role in this process. In this review, we will discuss the role of PI3P in autophagosome formation from three different perspectives: PI3-kinase, PI3-binding proteins, and PI3-phosphatase. Recent developments in this field suggest that the local PI3P concentration is dynamically regulated during autophagy, and that this molecule is critical to the proper control of autophagy.
authors.affiliation: Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, Japan. takenoda@biken.osaka-u.ac.jp
authors.forename: Takeshi
authors.initials: T
authors.lastname: Noda
authors.forename: Kohichi
authors.initials: K
authors.lastname: Matsunaga
authors.forename: Naoko
authors.initials: N
authors.lastname: Taguchi-Atarashi
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Yoshimori
mesh_terms: D000818:Animals; D001343:Autophagy; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D010588:Phagosomes / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism
chemical_list: D018129:Phosphatidylinositol Phosphates; D019869:Phosphatidylinositol 3-Kinases; D010744:Phosphoric Monoester Hydrolases