Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology.
Genome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed significant heterozygote advantage for HLA class I alleles and NHL, and particularly DLBCL (P trend = .01 for elevated risk with increasing number of homozygous alleles). Our results support a role for HLA in the etiology of NHL and its subtypes.
Wang
Sophia S
SS
Division of Cancer Etiology, Department of Population Sciences, City of Hope, Duarte, CA 91010, USA. sowang@coh.org
Abdou
Amr M
AM
Morton
Lindsay M
LM
Thomas
Rasmi
R
Cerhan
James R
JR
Gao
Xiaojiang
X
Cozen
Wendy
W
Rothman
Nathaniel
N
Davis
Scott
S
Severson
Richard K
RK
Bernstein
Leslie
L
Hartge
Patricia
P
Carrington
Mary
M
D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D055106:Genome-Wide Association Study; D006579:Heterozygote; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II
Cancer Res. 2006 Oct 1;66(19):9771-80
17018637
Hepatology. 1998 Jan;27(1):240-4
9425943
J Gastroenterol Hepatol. 2008 Nov;23(11):1716-21
18761557
J Viral Hepat. 2007 Dec;14(12):841-8
18070287
Leukemia. 2010 May;24(5):1055-8
20147981
J Neuroimmunol. 2002 Jan;122(1-2):140-5
11777553
Nat Genet. 2009 Aug;41(8):873-5
19620980
Nat Genet. 2006 Oct;38(10):1166-72
16998491
J Immunol. 2004 Oct 1;173(7):4273-6
15383555
Am J Epidemiol. 2010 Feb 1;171(3):267-76
20047977
J Natl Cancer Inst Monogr. 2003;(31):35-40
12807943
J Hepatol. 1997 Mar;26(3):503-7
9075656
Nature. 1975 Jul 3;256(5512):50-2
1079575
J Hepatol. 1997 Aug;27(2):259-64
9288598
Science. 1999 Mar 12;283(5408):1748-52
10073943
Arthritis Rheum. 2010 May;62(5):1236-45
20131291
Lancet Oncol. 2006 Jan;7(1):27-38
16389181