title: Follicular non-Hodgkin's lymphoma.
abstract: Follicular non-Hodgkin's lymphoma (NHL) is a unique subtype of NHL, which is indolent, incurable with a high prevalence of residual mass after treatment, and may transform to more aggressive NHL. The aim of this review is to (1) describe the histological and flow cytometry characteristics of follicular NHL; (2) introduce the Follicular Lymphoma International Prognostic Index 2 (FLIPI-2), which allows better treatment selection and patient stratification for clinical trials; (3) illustrate the classic and atypical ultrasound, computed tomography (CT), magnetic resonance imaging (MRI), and positron-emission tomography (PET)/CT appearance of follicular NHL; and (4) characterize the appearance of nodal and extranodal follicular NHL with pathological correlation. Imaging is essential in every step of the management of patients with follicular lymphoma. Overall survival is improved with better predictive tools and new targeted biological therapies. Radiologists should be aware of possible active residual mass, indolent recurrence, transformation, and association with other primary cancers in patients treated for follicular lymphoma.
authors.affiliation: Department of Radiology, Boston University School of Medicine, FGH Building, 3rd Floor, Boston, MA 02118, USA. Daichi.Hayashi@bmc.org
authors.forename: D
authors.initials: D
authors.lastname: Hayashi
authors.forename: J C
authors.initials: JC
authors.lastname: Lee
authors.forename: B
authors.initials: B
authors.lastname: Devenney-Cakir
authors.forename: S
authors.initials: S
authors.lastname: Zaim
authors.forename: S
authors.initials: S
authors.lastname: Ounadjela
authors.forename: P
authors.initials: P
authors.lastname: Solal-Céligny
authors.forename: M
authors.initials: M
authors.lastname: Juweid
authors.forename: A
authors.initials: A
authors.lastname: Guermazi
mesh_terms: D000328:Adult; D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008224:Lymphoma, Follicular / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology; D009367:Neoplasm Staging / Q000379:methods; D018365:Neoplasm, Residual; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000473:pathology; D011379:Prognosis