Nursing our microbiota: molecular linkages between bifidobacteria and milk oligosaccharides.
As the sole nutrition provided to infants, bioactive molecules dissolved in milk influence the development of our gut microbiota. Accordingly, human milk oligosaccharides (HMOs) are minimally digested by the infant and persist to negatively and positively regulate gut microbiota. Infant-type bifidobacteria utilize these soluble carbohydrate oligomers by convergent mechanisms. Bifidobacterium longum subsp. infantis efficiently consumes several small mass HMOs and possesses a large gene cluster and other loci dedicated to HMO metabolism. In contrast, adult-associated bifidobacteria such as the closely related B. longum subsp. longum are deficient for HMO utilization, although they retain the capacity to ferment plant oligosaccharides and constituent pentose sugars. Thus, the ability to subsist on HMO could demark infant-associated ecotypes potentially adapted to colonize the nursing infant.
Sela
David A
DA
Microbiology Graduate Group, University of California, Davis, CA 95616, USA.
Mills
David A
DA
D001644:Bifidobacterium / Q000254:growth & development / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000382:microbiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D008895:Milk, Human / Q000737:chemistry*; D009844:Oligosaccharides / Q000378:metabolism*
D009844:Oligosaccharides
J Nutr. 2006 Aug;136(8):2127-30
16857829
Biosci Biotechnol Biochem. 2009 May;73(5):1175-9
19420691
J Mol Microbiol Biotechnol. 2007;12(1-2):9-19
17183207
J Biol Chem. 2008 May 9;283(19):13165-73
18332142
Glycoconj J. 2001 May;18(5):357-71
11925504
Appl Environ Microbiol. 2002 Jan;68(1):219-26
11772630
Microbiology (Reading). 2006 Nov;152(Pt 11):3281-3290
17074899
Res Microbiol. 2007 Jan-Feb;158(1):31-7
17224259
Microb Biotechnol. 2009 May;2(3):333-42
21261928
Pediatrics. 1993 Mar;91(3):637-41
8441573
J Agric Food Chem. 2007 Oct 31;55(22):8914-9
17915960
Annu Rev Nutr. 2000;20:699-722
10940350
Pediatr Res. 2004 Oct;56(4):536-40
15295093
Appl Environ Microbiol. 2008 Mar;74(6):1936-40
18223105
J Anim Sci. 2009 Apr;87(13 Suppl):26-34
19028867
Isotopes Environ Health Stud. 1999;35(1-2):119-25
10902537
Nucleic Acids Res. 2008 Jan;36(Database issue):D475-9
17981842
BMC Microbiol. 2009 Jun 09;9:123
19508720
Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):18-22
7904066
J Bacteriol. 2009 Jul;191(13):4144-51
19376856
Appl Environ Microbiol. 2007 Oct;73(20):6444-9
17720833
Appl Environ Microbiol. 2008 Jul;74(13):3996-4004
18469123
Science. 2003 Mar 28;299(5615):2074-6
12663928
J Biol Chem. 2003 Apr 18;278(16):14112-20
12562767
PLoS Biol. 2007 Jul;5(7):e177
17594176
J Pediatr Gastroenterol Nutr. 2000 Jan;30(1):61-7
10630441
Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18964-9
19033196
Pediatrics. 2007 Mar;119(3):e724-32
17332189
BMC Genomics. 2008 May 27;9:247
18505588
Appl Environ Microbiol. 2009 May;75(9):2668-76
19286790
Int J Syst Evol Microbiol. 2008 Apr;58(Pt 4):767-72
18398167
Nucleic Acids Res. 2008 Jan;36(Database issue):D528-33
17933782
J Nutr. 2008 Jun;138(6):1091-5
18492839
J Appl Microbiol. 2008 Feb;104(2):305-44
18215222
Microbiol Mol Biol Rev. 2007 Sep;71(3):495-548
17804669
J Nutr. 2005 May;135(5):1289-93
15867326
Appl Environ Microbiol. 2005 Jun;71(6):3158-62
15933016
Pediatrics. 1983 Sep;72(3):317-21
6412205
Appl Environ Microbiol. 2010 Jan;76(1):54-9
19854932
Glycobiology. 2005 Jan;15(1):31-41
15342550
Curr Issues Intest Microbiol. 2003 Sep;4(2):61-9
14503690
J Biol Chem. 2007 Jun 22;282(25):18497-18509
17459873
Mol Nutr Food Res. 2007 Nov;51(11):1398-405
17966141
J Bacteriol. 2004 Aug;186(15):4885-93
15262925
Acta Paediatr. 2009 Feb;98(2):229-38
19143664
Appl Environ Microbiol. 2006 Oct;72(10):6854-8
16950914
Eur J Clin Nutr. 2008 Apr;62(4):488-94
17375110
Chem Phys Lipids. 2007 Nov;150(1):1-11
17686469
J Mammary Gland Biol Neoplasia. 2002 Jul;7(3):225-52
12751889
DNA Res. 2007 Aug 31;14(4):169-81
17916580
Nat Rev Microbiol. 2009 Jan;7(1):61-71
19029955
Glycobiology. 2009 Sep;19(9):1010-7
19520709
Glycobiology. 2004 Mar;14(3):253-63
14638628
J Nutr. 2007 Mar;137(3 Suppl 2):847S-9S
17311985
J Nutr. 2000 Dec;130(12):3014-20
11110861
Curr Probl Pediatr Adolesc Health Care. 2007 Jan;37(1):7-36
17157245
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Sep 1;63(Pt 9):751-3
17768345
Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14422-7
12381787
J Nutr. 1998 Jan;128(1):11-9
9430596
Acta Paediatr Suppl. 2005 Oct;94(449):18-21
16214760
Biosci Biotechnol Biochem. 2007 Jun;71(6):1587-91
17587697
Appl Environ Microbiol. 2008 Oct;74(20):6271-9
18689518
Br J Nutr. 1999 Nov;82(5):375-82
10673910
Biosci Biotechnol Biochem. 2007 Aug;71(8):2101-4
17690443
Gastroenterology. 1995 Apr;108(4):975-82
7698613
Appl Environ Microbiol. 2007 Jan;73(2):545-53
17098914
Antonie Van Leeuwenhoek. 2008 Jun;94(1):35-50
18338233
Infect Immun. 1999 Jul;67(7):3302-7
10377105
Proc Natl Acad Sci U S A. 1998 Sep 29;95(20):11751-6
9751737
J Agric Food Chem. 2006 Oct 4;54(20):7471-80
17002410
J Infect Dis. 1986 Feb;153(2):232-7
3484772
Arch Dis Child. 2006 Oct;91(10):814-9
16873437
Pediatrics. 2006 Aug;118(2):511-21
16882802
J Biol Chem. 2005 Nov 11;280(45):37415-22
16141207
Am J Clin Nutr. 2000 Jun;71(6):1589-96
10837303
Appl Environ Microbiol. 2006 Jun;72(6):4497-9
16751577
J Dairy Sci. 2008 Oct;91(10):3768-78
18832198