Aortic Customize: an in vivo feasibility study of a percutaneous technique for the repair of aortic aneurysms using injectable elastomer.
OBJECTIVE
This study aimed to test a percutaneous technique for aneurysm-sac filling by means of in situ polymerisation in an in vivo model.


METHODS
Aortic Customize is a new endovascular treatment concept for aortic aneurysms: a non-cross-linked liquid elastomer is injected to fill the aneurysm sac around a balloon-catheter. With this method, a compliant elastomer mould with a patent lumen is created.


METHODS
The formulation used in the experiments consisted of a two-component addition-cure liquid-silicone formulation, based on vinyl-terminated polydimethylsiloxane (PDMS).


METHODS
The concept of aneurysm-sac filling was tested in vivo in porcine experiments (n = 3).


RESULTS
In vivo porcine experiments with the sac-filling application showed successful exclusion of the created aneurysms with patent lumens and absence of endoleaks. The aneurysms were excluded successfully in the in vivo model, injecting elastomer through a 7-French catheter, filling up the entire aneurysm sac.


CONCLUSIONS
These in vivo experiments demonstrate that the principle of aneurysm-sac filling by means of in situ curing is feasible, excluding the aneurysm and creating a new lumen. Further long-term animal experiments must be done prior to consideration of clinical application.
Bosman
W M P F
WM
Department of Surgery, Leiden University Medical Center, Post box 9600, K6-R, 2300 RC Leiden, The Netherlands. w.m.p.f.bosman@lumc.nl
Vlot
J
J
van der Steenhoven
T J
TJ
van den Berg
O
O
Hamming
J F
JF
de Vries
A C
AC
Brom
H L F
HL
Jacobs
M J
MJ
D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000628:therapy*; D001027:Aortography; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000295:instrumentation* / Q000379:methods*; D002404:Catheterization; D004129:Dimethylpolysiloxanes / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005240:Feasibility Studies; D015552:Injections, Intralesional; D011474:Prosthesis Design; D012826:Silicone Elastomers / Q000008:administration & dosage*; D013552:Swine
D004129:Dimethylpolysiloxanes; D012826:Silicone Elastomers