Potential cancer gene therapy by baculoviral transduction.
Many different types of therapeutic genes, ranging from suicide genes, tumor suppressor genes, to genes encoding tumor-specific antigens, have been successfully delivered by insect baculoviral vectors to treat tumours in animal models. These encouraging results observed to date underscore the potential for using the non-human baculovirus to combat human cancer. The present review outlines the advances in this area and highlights the challenges behind translating the findings from research with baculoviral vectors into clinical practice.
Wang
Shu
S
Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos #04-01. Singapore 138669, Singapore. swang@ibn.a-star.edu.sg
Balasundaram
Ghayathri
G
D000951:Antigens, Neoplasm / Q000235:genetics / Q000276:immunology; D016367:Baculoviridae / Q000235:genetics* / Q000276:immunology; D005796:Genes; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D009423:Nervous System Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy; D012306:Risk
D000951:Antigens, Neoplasm