Expression of podoplanin in Warthin tumours.
OBJECTIVE
Warthin tumour is the second most common benign tumour of the parotid gland. This study was designed to investigate the lymphatic vessels in Warthin tumours in an effort to understand better its pathogenesis.


METHODS
Tissue specimens of 31 patients (19 men and 11 women; mean age 57 years, median size of the tumours 2.86 cm) were analysed by means of immunohistochemistry applying the monoclonal antibody D2-40.


RESULTS
We found numerous D2-40-positive sinus-like vessels particularly at the inner layer of the capsule.


CONCLUSIONS
Since subcapsular sinuses are a major morphological feature of lymph nodes in general, the finding of podoplanin expression in the large majority of subcapsular vessels in Warthin tumours confirms the view that this tumour has its origin in regional lymph nodes.
Hansen
Torsten
T
Institute of Pathology, University Medical Center, Johannes Gutenberg University of Mainz, Langenbeckstr. 1, 55101 Mainz, Germany. hansen@pathologie.klinik.uni-mainz.de
Kirkpatrick
C James
CJ
D000235:Adenolymphoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D014408:Biomarkers, Tumor / Q000032:analysis*; D042783:Endothelial Cells / Q000473:pathology; D004729:Endothelium, Lymphatic / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D042601:Lymphatic Vessels / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis*; D008875:Middle Aged; D010307:Parotid Neoplasms / Q000473:pathology*; D000098853:Podoplanin
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D014408:Biomarkers, Tumor; D008562:Membrane Glycoproteins; C117468:PDPN protein, human; D000098853:Podoplanin; C500987:monoclonal antibody D2-40
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