Increased leukotriene E4 excretion in systemic mastocytosis.
Cysteinyl leukotrienes such as LTE(4) are produced by mast cells, neutrophils, eosinophils, and macrophages. LTE(4) levels have not been reported in systemic mastocytosis, a disorder with a large increase in mast cell numbers. Urinary LTE(4) from patients referred for symptoms potentially due to mast cell degranulation or systemic mastocytosis was measured by a commercial cysteinyl leukotriene enzyme immunoassay kit. The diagnosis of systemic mastocytosis was established using current World Health Organization criteria. Compared with a control group of patients with various potential mast cell-related symptoms (e.g., "spells"), patients with systemic mastocytosis had a significant (P=.01) increase in urinary LTE(4) excretion, whether expressed as LTE(4) ng/g creatinine or as LTE(4) ng/24h. There was a moderate correlation of LTE(4) ng/24h with excretion of N-methyl histamine and serum tryptase but not with urinary 11beta-prostaglandin F(2alpha) (11beta-PGF(2alpha)) excretion. LTE(4) excretion is increased in patients with systemic mastocytosis and potentially contributes to clinical symptoms.
Butterfield
Joseph H
JH
Division of Allergic Diseases, Mayo Clinic, 200 SW 1st Street, Rochester, MN 55905, USA. butterfield.joseph@mayo.edu
D015237:Dinoprost / Q000652:urine; D006801:Humans; D017999:Leukotriene E4 / Q000378:metabolism* / Q000652:urine; D034721:Mastocytosis, Systemic / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008761:Methylhistamines / Q000652:urine; D053802:Tryptases / Q000097:blood
D008761:Methylhistamines; D017999:Leukotriene E4; D015237:Dinoprost; D053802:Tryptases