title: Naloxone effects on behavior of inbred mice with different response to emotional stress in open field test.
abstract: Effects of nonspecific opiate receptor antagonist naloxone in doses of 0.1, 0.5, 1.0, 5.0, 10.0 mg/kg on open field behavior and spontaneous motor activity were studied in male BALB/c and C57Bl/6 mice. Differently directed effects of naloxone on behavioral parameters of emotional-stress reaction in BALB/c and C57Bl/6 mice were observed. Naloxone increased motor activity in the open field test in BALB/c mice, but decreased it in C57Bl/6 mice. In the absence of stress, naloxone in the studied dose range did not affect spontaneous motor activity in C57Bl/6 mice, and significantly reduced activity in BALB/c mice in doses 0.5 and 1.0 mg/kg.
authors.affiliation: Department of Pharmacogenetics V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. av-nadorova@mail.ru
authors.forename: A V
authors.initials: AV
authors.lastname: Nadorova
authors.forename: M M
authors.initials: MM
authors.lastname: Kozlovskaja
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009483:Neuropsychological Tests; D013315:Stress, Psychological
chemical_list: D009292:Narcotic Antagonists; D009270:Naloxone