Effect of neuroleptic haloperidol, L-DOPA precursor dopamine, and neurotoxic dopamine analog 6-OHDA on acquisition of conditioned defensive reflex in edible snail.
The effect of neuroleptic haloperidol, a dopamine precursor L-DOPA, and dopamine analog 6-OHDA on the development of conditioned defensive reflex was studied in edible snails. Injection of L-DOPA to intact snails and to snails pretreated with 6-OHDA 2 h before learning session decelerated acquisition of the conditioned reflex and exerted a toxic action. In contrast, injection of 6-OHDA or haloperidol did not affect acquisition of the conditioned reflex.
Muranova
L N
LN
Kazan Physic and Technology Institute, Kazan Scientific Center, Russian Academy of Sciences, Russia.
Andrianov
V V
VV
Gainutdinov
Kh L
KhL
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects*; D004298:Dopamine / Q000494:pharmacology*; D015259:Dopamine Agents / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology*; D006372:Helix, Snails / Q000187:drug effects / Q000502:physiology; D016627:Oxidopamine / Q000494:pharmacology*; D013565:Sympatholytics / Q000494:pharmacology
D014150:Antipsychotic Agents; D015259:Dopamine Agents; D018492:Dopamine Antagonists; D013565:Sympatholytics; D016627:Oxidopamine; D006220:Haloperidol; D004298:Dopamine