Clerodane diterpenoids and prenylated flavonoids from Dodonaea viscosa.
Repeated column chromatography of the EtOAc-soluble fraction of the aerial parts of Dodonaea viscosa led to the isolation of two new modified clerodanes, methyl dodovisate A (1) and methyl dodovisate B (2), two new prenylated flavonoids, 5,7,4'-trihydroxy-3',5'-di(3-methylbut-2-enyl)-3,6-dimethoxyflavone (10) and 5,7,4'-trihydroxy-3'-(4-hydroxy-3-methylbutyl)-5'-(3-methylbut-2-enyl)-3,6-dimethoxyflavone (11), together with eight known compounds, dodonic acid (3), hautriwaic acid (4), hautriwaic lactone (5), (+)-hardwickiic acid (6), 5alpha-hydroxy-1,2-dehydro-5,10-dihydroprintzianic acid methyl ester (7), strictic acid (8), dodonolide (9), and aliarin (12). The structures of the new compounds were elucidated by spectroscopic data analysis. Compounds 1-9 and 11 were evaluated on larvicidal activity against the fourth-instar larvae of Aedes albopictus and Culex pipens quinquefasciatus.
Niu
Hong-Mei
HM
Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
Zeng
Dong-Qin
DQ
Long
Chun-Lin
CL
Peng
Ying-Hui
YH
Wang
Yue-Hu
YH
Luo
Ji-Feng
JF
Wang
Hong-Sheng
HS
Shi
Ya-Na
YN
Tang
Gui-Hua
GH
Zhao
Fu-Wei
FW
D000330:Aedes / Q000187:drug effects; D000818:Animals; D003465:Culex / Q000187:drug effects; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D029631:Sapindaceae / Q000737:chemistry*
D045785:Diterpenes, Clerodane; D004365:Drugs, Chinese Herbal; D005419:Flavonoids