title: Evidence for a relationship between body mass and energy metabolism in the human brain.
abstract: Cerebral energy metabolism has been suggested to have an important function in body weight regulation. We therefore examined whether there is a relationship between body mass and adenosine triphosphate (ATP) metabolism in the human brain. On the basis of our earlier findings indicating a neuroprotective preferential energy supply of the brain, as compared with peripheral muscle on experimentally induced hypoglycemia, we examined whether this physiological response is preserved also in low-weight and obese participants. We included 45 healthy male subjects with a body mass index (BMI) ranging from 17 to 44 kg/m(2). Each participant underwent a hypoglycemic glucose-clamp intervention, and the ATP metabolism, that is, the content of high-energy phosphates phosphocreatine (PCr) and ATP, was measured repeatedly by (31)phosphor magnetic resonance spectroscopy ((31)P-MRS) in the cerebral cortex and skeletal muscle. Results show an inverse correlation between BMI and high-energy phosphate content in the brain (P<0.01), whereas there was no such relationship found between skeletal muscle and BMI. The hypoglycemic clamp intervention did not affect the ATP metabolism in both tissues. Our data show an inverse correlation between BMI and cerebral high-energy phosphate content in healthy humans, suggesting a close relationship between energetic supply of the brain and body weight regulation.
authors.affiliation: Department of Psychiatry and Psychotherapy, University of Luebeck, Ratzeburger Allee 160, Luebeck, Germany. andre.schmoller@uk-sh.de
authors.forename: André
authors.initials: A
authors.lastname: Schmoller
authors.forename: Torben
authors.initials: T
authors.lastname: Hass
authors.forename: Olga
authors.initials: O
authors.lastname: Strugovshchikova
authors.forename: Uwe H
authors.initials: UH
authors.lastname: Melchert
authors.forename: Harald G
authors.initials: HG
authors.lastname: Scholand-Engler
authors.forename: Achim
authors.initials: A
authors.lastname: Peters
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schweiger
authors.forename: Fritz
authors.initials: F
authors.lastname: Hohagen
authors.forename: Kerstin M
authors.initials: KM
authors.lastname: Oltmanns
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D001835:Body Weight; D001921:Brain / Q000033:anatomy & histology / Q000378:metabolism*; D004734:Energy Metabolism / Q000502:physiology*; D015309:Glucose Clamp Technique; D006801:Humans; D007328:Insulin / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D009765:Obesity / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin; D010710:Phosphates; D000255:Adenosine Triphosphate
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