title: Magnetic resonance spectroscopy in metabolic and molecular imaging and diagnosis of cancer.
authors.affiliation: JHU ICMIC Program, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. kglunde@mri.jhu.edu
authors.forename: Kristine
authors.initials: K
authors.lastname: Glunde
authors.forename: Dmitri
authors.initials: D
authors.lastname: Artemov
authors.forename: Marie-France
authors.initials: MF
authors.lastname: Penet
authors.forename: Michael A
authors.initials: MA
authors.lastname: Jacobs
authors.forename: Zaver M
authors.initials: ZM
authors.lastname: Bhujwalla
mesh_terms: D000818:Animals; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D057054:Molecular Imaging / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism* / Q000473:pathology / Q000628:therapy; D016896:Treatment Outcome
references.citation: Mol Cell Biochem. 2005 Dec;280(1-2):1-8
references.pmid: 16511951
references.citation: Curr Mol Med. 2009 May;9(4):442-58
references.pmid: 19519402
references.citation: NMR Biomed. 2006 Feb;19(1):30-40
references.pmid: 16229059
references.citation: Int J Radiat Oncol Biol Phys. 2005 May 1;62(1):20-31
references.pmid: 15850898
references.citation: Radiology. 2001 Jul;220(1):40-6
references.pmid: 11425970
references.citation: Cancer Res. 1989 Dec 1;49(23):6449-65
references.pmid: 2684393
references.citation: NMR Biomed. 2007 Apr;20(2):128-40
references.pmid: 17006886
references.citation: Cancer Res. 2006 Oct 15;66(20):9929-36
references.pmid: 17047055
references.citation: NMR Biomed. 2002 Apr;15(2):114-9
references.pmid: 11870907
references.citation: Int J Radiat Oncol Biol Phys. 2000 Jul 1;47(4):1085-96
references.pmid: 10863082
references.citation: Radiology. 2004 Nov;233(2):424-31
references.pmid: 15516615
references.citation: Nat Med. 2007 Nov;13(11):1382-7
references.pmid: 17965722
references.citation: Magn Reson Med. 1993 Apr;29(4):546-50
references.pmid: 8464371
references.citation: NMR Biomed. 2009 Jan;22(1):65-76
references.pmid: 17957820
references.citation: Cancer Res. 1999 Apr 15;59(8):1861-8
references.pmid: 10213493
references.citation: Cancer Res. 2001 Sep 1;61(17):6524-31
references.pmid: 11522650
references.citation: Anticancer Res. 1996 May-Jun;16(3B):1429-39
references.pmid: 8694511
references.citation: Neoplasia. 2003 Jul-Aug;5(4):308-18
references.pmid: 14511402
references.citation: Chem Soc Rev. 2006 Jun;35(6):500-11
references.pmid: 16729144
references.citation: NMR Biomed. 1992 Sep-Oct;5(5):279-89
references.pmid: 1449969
references.citation: Biol Res. 2002;35(1):9-26
references.pmid: 12125211
references.citation: Neuro Oncol. 2010 Jan;12(1):71-9
references.pmid: 20150369
references.citation: Magn Reson Imaging. 2006 Jun;24(5):541-8
references.pmid: 16735174
references.citation: Magn Reson Med. 1998 Jan;39(1):53-60
references.pmid: 9438437
references.citation: Magn Reson Imaging. 2005 Feb;23(2):153-7
references.pmid: 15833606
references.citation: Cancer Res. 2001 Jul 1;61(13):5318-25
references.pmid: 11431377
references.citation: Cancer Res. 2005 Apr 15;65(8):3356-63
references.pmid: 15833869
references.citation: Clin Exp Metastasis. 2009;26(1):19-34
references.pmid: 18543068
references.citation: Cancer Res. 1998 May 1;58(9):1825-32
references.pmid: 9581820
references.citation: Cancer Res. 1976 Oct;36(10):3761-5
references.pmid: 986241
references.citation: Front Biosci. 2008 Jan 01;13:1371-84
references.pmid: 17981636
references.citation: Pharmacogenomics. 2006 Oct;7(7):1109-23
references.pmid: 17054420
references.citation: Magn Reson Med. 1994 Jul;32(1):88-97
references.pmid: 8084241
references.citation: Methods Enzymol. 2004;386:378-418
references.pmid: 15120262
references.citation: Cancer Res. 1988 May 15;48(10):2641-58
references.pmid: 3282647
references.citation: Radiology. 2005 Aug;236(2):465-75
references.pmid: 16040903
references.citation: Int J Radiat Oncol Biol Phys. 2001 Jun 1;50(2):317-23
references.pmid: 11380217
references.citation: Nat Rev Cancer. 2004 Nov;4(11):891-9
references.pmid: 15516961
references.citation: NMR Biomed. 1998 Nov;11(8):414-22
references.pmid: 10221584
references.citation: J Magn Reson Imaging. 2004 Jan;19(1):68-75
references.pmid: 14696222
references.citation: Cancer Res. 2005 Jul 1;65(13):5647-53
references.pmid: 15994937
references.citation: J Cell Biochem. 2003 Oct 15;90(3):525-33
references.pmid: 14523987
references.citation: Oncogene. 2002 Jun 20;21(27):4317-22
references.pmid: 12082619
references.citation: Adv Drug Deliv Rev. 2000 Mar 15;41(1):75-89
references.pmid: 10699306
references.citation: Radiol Clin North Am. 2000 Jan;38(1):115-38, viii-ix
references.pmid: 10664669
references.citation: Magn Reson Med. 2000 Nov;44(5):799-802
references.pmid: 11064415
references.citation: Magn Reson Med. 1991 Jul;20(1):17-26
references.pmid: 1943658
references.citation: Magn Reson Med. 1993 Jul;30(1):18-27
references.pmid: 8371670
references.citation: Radiology. 1996 Mar;198(3):795-805
references.pmid: 8628874
references.citation: Curr Med Chem. 1999 Jun;6(6):481-99
references.pmid: 10213795
references.citation: Nat Med. 2003 Aug;9(8):1085-90
references.pmid: 12872167
references.citation: NMR Biomed. 1996 Aug;9(5):185-94
references.pmid: 9067999
references.citation: J Proteome Res. 2007 Feb;6(2):498-505
references.pmid: 17269706
references.citation: Magn Reson Med. 2001 Jul;46(1):49-57
references.pmid: 11443710
references.citation: Anticancer Drug Des. 1998 Sep;13(6):703-30
references.pmid: 9755726
references.citation: Am J Physiol Endocrinol Metab. 2002 Oct;283(4):E623-30
references.pmid: 12217878
references.citation: J Am Chem Soc. 2006 Oct 18;128(41):13474-8
references.pmid: 17031960
references.citation: Lancet. 1983 Jun 25;1(8339):1435-6
references.pmid: 6134191
references.citation: Cancer Res. 1999 Jan 1;59(1):80-4
references.pmid: 9892190
references.citation: Radiology. 1972 Oct;105(1):135-42
references.pmid: 4506641
references.citation: Magn Reson Med. 2005 Jan;53(1):22-9
references.pmid: 15690498
references.citation: Cancer Res. 2009 Apr 15;69(8):3464-71
references.pmid: 19336572
references.citation: Cancer Res. 2001 Apr 1;61(7):3039-44
references.pmid: 11306485
references.citation: Bioorg Med Chem. 2002 Jul;10(7):2215-31
references.pmid: 11983519
references.citation: Cancer Res. 2009 Nov 15;69(22):8822-9
references.pmid: 19861534
references.citation: Clin Cancer Res. 2008 Jan 15;14(2):515-22
references.pmid: 18223227
references.citation: Cancer Res. 2009 Mar 15;69(6):2260-8
references.pmid: 19276390
references.citation: Cancer Res. 2005 Apr 15;65(8):3030-4
references.pmid: 15833828
references.citation: Eur J Cancer. 1993;29A(7):940-2
references.pmid: 8499146
references.citation: Br J Cancer. 2004 Jun 14;90(12):2326-31
references.pmid: 15162152
references.citation: Biochem Biophys Res Commun. 2002 Aug 23;296(3):580-3
references.pmid: 12176020
references.citation: J Neurosurg. 2002 Jun;96(6):1023-31
references.pmid: 12066902
references.citation: Cancer Res. 2007 Aug 15;67(16):7638-45
references.pmid: 17699768
references.citation: NMR Biomed. 1999 Nov;12(7):413-39
references.pmid: 10654290
references.citation: Radiology. 2009 Jun;251(3):653-62
references.pmid: 19276320
references.citation: Mol Cancer Res. 2003 Sep;1(11):789-800
references.pmid: 14517341
references.citation: NMR Biomed. 1999 Dec;12(8):495-504
references.pmid: 10668042
references.citation: NMR Biomed. 1998 Nov;11(8):395-404
references.pmid: 10221582
references.citation: Cancer Res. 1988 Sep 1;48(17):4736-42
references.pmid: 3409214
references.citation: Annu Rev Biomed Eng. 2005;7:287-326
references.pmid: 16004573
references.citation: J Magn Reson Imaging. 2002 Oct;16(4):464-76
references.pmid: 12353260
references.citation: Cancer Res. 2005 Dec 1;65(23):11034-43
references.pmid: 16322253
references.citation: Magn Reson Med. 2009 Mar;61(3):634-8
references.pmid: 19097235
references.citation: NMR Biomed. 1989 Dec;2(5-6):290-7
references.pmid: 2701809
references.citation: MAGMA. 2006 May;19(2):96-104
references.pmid: 16779565
references.citation: Magn Reson Med. 2008 Oct;60(4):803-12
references.pmid: 18816830
references.citation: Br J Cancer. 2002 Mar 18;86(6):963-70
references.pmid: 11953830
references.citation: Magn Reson Q. 1994 Dec;10(4):191-247
references.pmid: 7873353
references.citation: NMR Biomed. 2004 Jun;17(4):191-205
references.pmid: 15229932
references.citation: Science. 2009 May 22;324(5930):1029-33
references.pmid: 19460998
references.citation: Magn Reson Imaging. 1996;14(5):541-51
references.pmid: 8843366
references.citation: Cancer Lett. 2000 Dec 20;161(2):207-14
references.pmid: 11090971
references.citation: NMR Biomed. 1992 Sep-Oct;5(5):303-24
references.pmid: 1333263
references.citation: Cancer Res. 2006 Sep 15;66(18):8927-30
references.pmid: 16982728
references.citation: Int J Radiat Oncol Biol Phys. 1994 Apr 30;29(1):95-103
references.pmid: 8175452
references.citation: Science. 1983 Jun 10;220(4602):1170-3
references.pmid: 6857240
references.citation: Clin Imaging. 2005 Jan-Feb;29(1):10-5
references.pmid: 15859012
references.citation: Magn Reson Med. 2003 Feb;49(2):223-32
references.pmid: 12541241
references.citation: Neoplasia. 2000 Jan-Apr;2(1-2):152-65
references.pmid: 10933074
references.citation: Magn Reson Med. 1999 Feb;41(2):257-67
references.pmid: 10080272
references.citation: Cancer Lett. 2005 Oct 18;228(1-2):247-55
references.pmid: 15946794
references.citation: Magn Reson Med. 1988 Jul;7(3):319-36
references.pmid: 3205148
references.citation: Magn Reson Med. 2006 Feb;55(2):309-15
references.pmid: 16402385
references.citation: Nature. 2008 Apr 3;452(7187):580-9
references.pmid: 18385732
references.citation: Cancer Res. 2004 Jun 15;64(12):4270-6
references.pmid: 15205341
references.citation: Magn Reson Med. 2006 Apr;55(4):743-8
references.pmid: 16506157
references.citation: Radiology. 2002 Mar;222(3):715-21
references.pmid: 11867790
references.citation: Magn Reson Med. 2003 Nov;50(5):944-54
references.pmid: 14587005
references.citation: Magn Reson Imaging. 2005 May;23(4):571-6
references.pmid: 15919603
references.citation: NMR Biomed. 2005 Oct;18(6):371-82
references.pmid: 15959923
references.citation: NMR Biomed. 2002 Aug;15(5):327-37
references.pmid: 12203224
references.citation: Drug Discov Today. 2008 Jun;13(11-12):473-80
references.pmid: 18549972
references.citation: Rev Urol. 2006;8 Suppl 1:S4-S10
references.pmid: 17021625
references.citation: J Pharmacol Exp Ther. 1996 May;277(2):1049-57
references.pmid: 8627516
references.citation: Nat Rev Cancer. 2004 Jul;4(7):551-61
references.pmid: 15229480
references.citation: Mol Cancer Ther. 2008 Aug;7(8):2556-65
references.pmid: 18723500
references.citation: Cancer Res. 2006 Jan 1;66(1):427-34
references.pmid: 16397258
references.citation: Nat Med. 2007 Mar;13(3):372-7
references.pmid: 17322898
references.citation: Br J Cancer. 2006 Feb 13;94(3):427-35
references.pmid: 16465174
references.citation: J Neurochem. 1999 Jun;72(6):2445-55
references.pmid: 10349854
references.citation: Oncogene. 2002 Jan 31;21(6):937-46
references.pmid: 11840339
references.citation: Int J Radiat Oncol Biol Phys. 1992;22(1):95-101
references.pmid: 1727132
references.citation: Magn Reson Med. 2005 Jul;54(1):43-50
references.pmid: 15968678
references.citation: Anticancer Res. 1996 May-Jun;16(3B):1375-80
references.pmid: 8694504
references.citation: Oncogene. 2004 Oct 28;23(50):8247-59
references.pmid: 15378008
references.citation: Chem Commun (Camb). 2009 Oct 28;(40):6044-6
references.pmid: 19809638
references.citation: Nature. 1998 Feb 19;391(6669):806-11
references.pmid: 9486653
references.citation: Neoplasia. 2001 May-Jun;3(3):227-35
references.pmid: 11494116
references.citation: NMR Biomed. 2006 Jun;19(4):504-12
references.pmid: 16763965
references.citation: Magn Reson Med. 1993 Jan;29(1):38-43
references.pmid: 8110206
references.citation: Front Biosci. 2008 Jan 01;13:1733-52
references.pmid: 17981664
references.citation: Neurology. 2005 Jun 28;64(12):2085-9
references.pmid: 15985578
references.citation: Proc Natl Acad Sci U S A. 2003 Sep 2;100(18):10158-63
references.pmid: 12930897
references.citation: Magn Reson Med. 2008 Dec;60(6):1298-305
references.pmid: 19030163
references.citation: Magn Reson Med. 2001 Aug;46(2):228-39
references.pmid: 11477625
references.citation: Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19801-6
references.pmid: 19903889
references.citation: Int J Radiat Oncol Biol Phys. 1986 May;12(5):793-9
references.pmid: 3710861
references.citation: Nature. 1980 Jan 10;283(5743):167-70
references.pmid: 7350541
references.citation: Bioorg Med Chem. 1994 May;2(5):305-14
references.pmid: 7922141
references.citation: Magn Reson Med. 1995 Feb;33(2):151-5
references.pmid: 7707903
references.citation: Top Magn Reson Imaging. 2008 Dec;19(6):261-72
references.pmid: 19512848
references.citation: Magn Reson Med. 2006 Jun;55(6):1257-64
references.pmid: 16685733
references.citation: J Magn Reson. 1998 Nov;135(1):194-202
references.pmid: 9799694
references.citation: Magn Reson Med. 2006 Apr;55(4):755-61
references.pmid: 16508914
references.citation: Biochem J. 2007 Jul 1;405(1):1-9
references.pmid: 17555402
references.citation: Int J Cancer. 2007 Apr 15;120(8):1721-30
references.pmid: 17236204
references.citation: Magn Reson Med. 1988 Sep;8(1):104-9
references.pmid: 3173064
references.citation: Proc Natl Acad Sci U S A. 1982 Jun;79(11):3523-6
references.pmid: 6954498
references.citation: Radiology. 1996 Aug;200(2):489-96
references.pmid: 8685346
references.citation: J Biol Chem. 1973 Oct 25;248(20):7276-8
references.pmid: 4743524
references.citation: Radiat Res. 1989 Dec;120(3):477-93
references.pmid: 2594969
references.citation: Br J Cancer. 2009 Mar 24;100(6):923-31
references.pmid: 19259085
references.citation: IDrugs. 2001 Apr;4(4):419-26
references.pmid: 16015482
references.citation: Nat Biotechnol. 2007 Feb;25(2):217-9
references.pmid: 17259977
references.citation: Clin Cancer Res. 2007 Jun 15;13(12):3738-47
references.pmid: 17575240
references.citation: J Neurosurg. 1997 Oct;87(4):525-34
references.pmid: 9322843
references.citation: Eur Radiol. 2005 May;15(5):1037-43
references.pmid: 15351906
references.citation: Magn Reson Med. 1999 Apr;41(4):743-50
references.pmid: 10332850
references.citation: NMR Biomed. 2008 Oct;21(8):899-907
references.pmid: 18574806
references.citation: Clin Exp Metastasis. 1996 Mar;14(2):176-86
references.pmid: 8605731
references.citation: Neoplasia. 2000 Jan-Apr;2(1-2):139-51
references.pmid: 10933073
references.citation: Cancer Res. 2008 Jan 1;68(1):172-80
references.pmid: 18172309
references.citation: Nature. 2008 Apr 3;452(7187):548-52
references.pmid: 18385728
references.citation: AJR Am J Roentgenol. 1983 Dec;141(6):1101-10
references.pmid: 6196961
references.citation: J Cell Physiol. 2005 Mar;202(3):654-62
references.pmid: 15389572
references.citation: Magn Reson Med. 2002 Apr;47(4):639-48
references.pmid: 11948724
references.citation: Cancer Res. 2005 Oct 15;65(20):9369-76
references.pmid: 16230400
references.citation: J Comput Assist Tomogr. 1990 Jul-Aug;14(4):497-504
references.pmid: 2164536
references.citation: Int J Radiat Oncol Biol Phys. 1996 Dec 1;36(5):1251-61
references.pmid: 8985051
references.citation: J Magn Reson Imaging. 2005 Jan;21(1):23-8
references.pmid: 15611934
references.citation: Radiology. 1998 Oct;209(1):269-75
references.pmid: 9769842
references.citation: J Magn Reson Imaging. 2002 Sep;16(3):229-37
references.pmid: 12205577
references.citation: J Neuroimaging. 1995 Jul;5(3):157-63
references.pmid: 7626823
references.citation: Br J Cancer. 1991 Sep;64(3):425-7
references.pmid: 1911181
references.citation: NMR Biomed. 2005 Nov;18(7):413-20
references.pmid: 16075415
references.citation: Br J Surg. 2001 Sep;88(9):1234-40
references.pmid: 11531873
references.citation: NMR Biomed. 2006 Aug;19(5):593-8
references.pmid: 16645958
references.citation: Leuk Res. 2002 Oct;26(10):919-26
references.pmid: 12163053
references.citation: Prostate Suppl. 1992;4:43-50
references.pmid: 1374177
references.citation: Q Rev Biophys. 1984 Feb;17(1):83-124
references.pmid: 6091170
references.citation: Magn Reson Med. 2003 Dec;50(6):1134-43
references.pmid: 14648561
references.citation: Am J Physiol. 1994 Jul;267(1 Pt 1):C195-203
references.pmid: 8048479
references.citation: Br J Neurosurg. 2002 Aug;16(4):329-34
references.pmid: 12389884
references.citation: Semin Oncol. 2004 Oct;31(5):605-17
references.pmid: 15497114
references.citation: J Magn Reson Imaging. 2002 Oct;16(4):451-63
references.pmid: 12353259
references.citation: Top Magn Reson Imaging. 1993 Winter;5(1):32-45
references.pmid: 8416687
references.citation: Adv Drug Deliv Rev. 2000 Mar 15;41(1):55-74
references.pmid: 10699305
references.citation: Magn Reson Med. 2004 Nov;52(5):1043-51
references.pmid: 15508152
references.citation: Breast Cancer Res. 2001;3(1):36-40
references.pmid: 11250743
references.citation: Cancer Res. 2008 Oct 15;68(20):8607-15
references.pmid: 18922937
references.citation: IEEE Eng Med Biol Mag. 2004 Sep-Oct;23(5):57-64
references.pmid: 15565800
references.citation: Magn Reson Med. 1993 Nov;30(5):544-51
references.pmid: 8259054
references.citation: Cancer Sci. 2009 Aug;100(8):1366-73
references.pmid: 19459851
references.citation: Mol Imaging. 2008 Mar-Apr;7(2):92-100
references.pmid: 18706291
references.citation: J Magn Reson. 2000 Mar;143(1):79-87
references.pmid: 10698648
references.citation: NMR Biomed. 1992 Nov-Dec;5(6):351-9
references.pmid: 1489671
references.citation: Neoplasia. 2000 Jan-Apr;2(1-2):166-89
references.pmid: 10933075
references.citation: Nature. 2008 Jun 12;453(7197):940-3
references.pmid: 18509335
references.citation: FEBS J. 2007 Mar;274(5):1132-9
references.pmid: 17298437
references.citation: Nature. 2004 Sep 16;431(7006):343-9
references.pmid: 15372041
references.citation: Br J Radiol. 2002 Dec;75(900):959-66
references.pmid: 12515704
references.citation: Nat Med. 1999 Nov;5(11):1323-7
references.pmid: 10546002