title: Object/context-specific memory deficits associated with loss of hippocampal granule cells after adrenalectomy in rats.
abstract: Chronic adrenalectomy (ADX) causes a gradual and selective loss of granule cells in the dentate gyrus (DG) of the rat. Here, we administered replacement corticosterone to rats beginning 10 wk after ADX. We then tested them in three discrimination tasks based on object novelty, location, or object/context association. Only during testing of the object/context association did ADX rats demonstrate deficits. These findings add to a body of evidence that the hippocampus is necessary when contextual information is important. We also confirm that memory deficits after chronic adrenalectomy are not a result of loss of corticosterone per se.
authors.affiliation: Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge AB T1K 3M4, Canada. simon.spanswick@uleth.ca
authors.forename: Simon C
authors.initials: SC
authors.lastname: Spanswick
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Sutherland
mesh_terms: D000315:Adrenalectomy / Q000009:adverse effects*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002452:Cell Count / Q000379:methods; D003345:Corticosterone / Q000494:pharmacology; D004193:Discrimination Learning / Q000502:physiology; D005106:Exploratory Behavior / Q000187:drug effects; D006624:Hippocampus / Q000473:pathology*; D007211:Indoles; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D009474:Neurons / Q000473:pathology*; D009483:Neuropsychological Tests; D051381:Rats; D013028:Space Perception / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects
chemical_list: D000893:Anti-Inflammatory Agents; D007211:Indoles; C007293:DAPI; D003345:Corticosterone
references.citation: Psychol Rev. 1995 Jul;102(3):419-457
references.pmid: 7624455
references.citation: Behav Neurosci. 1997 Jun;111(3):518-31
references.pmid: 9189267
references.citation: Prog Brain Res. 1990;83:287-300
references.pmid: 2392566
references.citation: Neurobiol Learn Mem. 2001 Jul;76(1):81-105
references.pmid: 11525255
references.citation: Philos Trans R Soc Lond B Biol Sci. 1971 Jul 1;262(841):23-81
references.pmid: 4399412
references.citation: Behav Neurosci. 2006 Aug;120(4):761-86
references.pmid: 16893284
references.citation: PLoS One. 2009;4(5):e5464
references.pmid: 19421325
references.citation: Hippocampus. 1995;5(1):1-15
references.pmid: 7787942
references.citation: Brain Res. 1991 Jul 19;554(1-2):312-5
references.pmid: 1933312
references.citation: J Neurosci. 2008 Jun 11;28(24):6211-9
references.pmid: 18550763
references.citation: Nature. 2004 Jul 22;430(6998):456-9
references.pmid: 15229614
references.citation: Science. 2009 Jul 10;325(5937):210-3
references.pmid: 19590004
references.citation: Hippocampus. 1996;6(6):601-20
references.pmid: 9034849
references.citation: Hippocampus. 2005;15(5):579-86
references.pmid: 15920719
references.citation: Learn Mem. 2009 Jan 29;16(2):147-54
references.pmid: 19181621
references.citation: Science. 1989 Jan 27;243(4890):535-8
references.pmid: 2911756
references.citation: Neuroscience. 1998 May;84(2):453-65
references.pmid: 9539216
references.citation: Hippocampus. 2001;11(1):8-17
references.pmid: 11261775
references.citation: Hippocampus. 1999;9(6):668-81
references.pmid: 10641760
references.citation: Learn Mem. 2002 Mar-Apr;9(2):49-57
references.pmid: 11992015
references.citation: Behav Brain Res. 1983 Feb;7(2):133-53
references.pmid: 6830648
references.citation: J Comp Neurol. 1993 Apr 15;330(3):337-51
references.pmid: 8468410
references.citation: Learn Mem. 2009 Sep 30;16(10):573-85
references.pmid: 19794181
references.citation: Hippocampus. 1993 Jul;3(3):359-71
references.pmid: 8353612
references.citation: Science. 1992 May 1;256(5057):675-7
references.pmid: 1585183
references.citation: Neurosci Lett. 1995 Jul 14;194(1-2):49-52
references.pmid: 7478210
references.citation: Hippocampus. 2007;17(2):137-46
references.pmid: 17183555
references.citation: Behav Neurosci. 2005 Feb;119(1):145-53
references.pmid: 15727520
references.citation: J Neurosci. 2008 Sep 3;28(36):9030-6
references.pmid: 18768697
references.citation: Learn Mem. 2009 Jun 24;16(7):417-20
references.pmid: 19553378
references.citation: Neuropsychologia. 2009 Aug;47(10):2107-13
references.pmid: 19467361
references.citation: Hippocampus. 2001;11(6):626-36
references.pmid: 11811656
references.citation: Behav Brain Res. 1990 Feb 12;37(1):57-79
references.pmid: 2310495
references.citation: Science. 2007 Feb 16;315(5814):961-6
references.pmid: 17303747
references.citation: Behav Brain Res. 2006 Jun 3;170(1):156-62
references.pmid: 16580742