title: Paraoxonase 1 (PON1) polymorphisms and risk for migraine.
abstract: The polymorphic enzyme human serum paraoxonase 1 (PON1), encoded by the gene PON1 (chromosome 7q21.3) plays a role as an antioxidant molecule through several mechanisms. Because oxidative stress has been implicated in the pathogenesis of migraine, we have investigated the possible association between the nonsynonymous polymorphisms 55LM and 192QR in the PON1 and the risk for migraine. We studied the frequency of the PON1 genotypes and allelic variants in 197 patients with migraine and 220 healthy controls using a TaqMan single nucleotide polymorphism analysis. The frequencies of the PON1 genotypes and PON1 allelic variants did not differ significantly between patients with migraine and controls, and were unrelated with gender, family history of migraine, and presence or absence of aura. The frequencies of the genotype PON1 192QQ and the allelic variant PON1 192Q were significantly higher in patients with earlier onset of migraine. The results of the present study suggest that PON1 polymorphisms are not related with the risk for migraine in Caucasian Spanish people, although PON1 192Q/Q genotype and PON1 192Q allelic variant should be related with an earlier onset of migraine.
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Extremadura, Badajoz, Spain.
authors.forename: Elena
authors.initials: E
authors.lastname: García-Martín
authors.forename: Carmen
authors.initials: C
authors.lastname: Martínez
authors.forename: Mercedes
authors.initials: M
authors.lastname: Serrador
authors.forename: Hortensia
authors.initials: H
authors.lastname: Alonso-Navarro
authors.forename: Francisco
authors.initials: F
authors.lastname: Navacerrada
authors.forename: José A G
authors.initials: JA
authors.lastname: Agúndez
authors.forename: Félix Javier
authors.initials: FJ
authors.lastname: Jiménez-Jiménez
mesh_terms: D000328:Adult; D043303:Aryldialkylphosphatase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
references.citation: Cephalalgia. 2004 Jul;24(7):528-32
references.pmid: 15196294
references.citation: Nat Genet. 2003 Feb;33(2):192-6
references.pmid: 12539047
references.citation: Psychiatr Genet. 2008 Dec;18(6):289-94
references.pmid: 19018234
references.citation: Cephalalgia. 1997 Aug;17(5):580-4
references.pmid: 9251872
references.citation: Lancet. 2005 Jul 30-Aug 5;366(9483):371-7
references.pmid: 16054936
references.citation: Cephalalgia. 2007 Oct;27(10):1136-41
references.pmid: 17725652
references.citation: Cephalalgia. 2005 May;25(5):353-8
references.pmid: 15839850
references.citation: Cephalalgia. 1994 Jun;14(3):215-8; discussion 181
references.pmid: 7954742
references.citation: Cephalalgia. 2004 Jan;24(1):37-43
references.pmid: 14687011
references.citation: Nat Genet. 1993 Jan;3(1):73-6
references.pmid: 8098250
references.citation: Curr Opin Lipidol. 2002 Aug;13(4):357-62
references.pmid: 12151850
references.citation: Cephalalgia. 2003 Feb;23(1):39-42
references.pmid: 12534579
references.citation: Biol Trace Elem Res. 2008 Winter;126(1-3):92-7
references.pmid: 18690416
references.citation: Tohoku J Exp Med. 2007 Jan;211(1):23-30
references.pmid: 17202769
references.citation: Atherosclerosis. 1998 Aug;139(2):341-9
references.pmid: 9712341
references.citation: Curr Opin Lipidol. 1996 Apr;7(2):69-76
references.pmid: 8743898
references.citation: J Mol Med (Berl). 2003 Dec;81(12):766-79
references.pmid: 14551701
references.citation: Cardiovasc Pathol. 2008 Jul-Aug;17(4):226-32
references.pmid: 18402813
references.citation: Cell. 1996 Nov 1;87(3):543-52
references.pmid: 8898206
references.citation: Am J Hum Genet. 1993 Mar;52(3):598-608
references.pmid: 7916578
references.citation: BMJ. 1995 Aug 26;311(7004):541-4
references.pmid: 7663209
references.citation: Pharmacol Rep. 2008 Jul-Aug;60(4):542-8
references.pmid: 18799823
references.citation: Toxicol Appl Pharmacol. 2001 May 15;173(1):1-6
references.pmid: 11350209