title: Plasmodium falciparum isolates with increased pfmdr1 copy number circulate in West Africa.
abstract: Amplification of pfmdr1 in Plasmodium falciparum is linked to resistance to aryl-amino-alcohols and in reduced susceptibility to artemisinins. We demonstrate here that duplicated pfmdr1 genotypes circulate in West Africa. The monitoring of this prevalence in Africa appears essential for determining the antimalarial policy and to maintain the efficiency of artemisinin-based combination therapy (ACT) for as long as possible.
authors.affiliation: Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
authors.forename: Benoit
authors.initials: B
authors.lastname: Witkowski
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Nicolau
authors.forename: Patrice Njomnang
authors.initials: PN
authors.lastname: Soh
authors.forename: Xavier
authors.initials: X
authors.lastname: Iriart
authors.forename: Sandie
authors.initials: S
authors.lastname: Menard
authors.forename: Muriel
authors.initials: M
authors.lastname: Alvarez
authors.forename: Bruno
authors.initials: B
authors.lastname: Marchou
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Magnaval
authors.forename: Françoise
authors.initials: F
authors.lastname: Benoit-Vical
authors.forename: Antoine
authors.initials: A
authors.lastname: Berry
mesh_terms: D000349:Africa; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D037621:Artemisinins / Q000627:therapeutic use; D018628:Gene Dosage; D005838:Genotype; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics* / Q000472:pathogenicity
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C513498:Mdr1 protein, Plasmodium falciparum
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