title: Nosocomial transmission of Candida pelliculosa fungemia in a pediatric intensive care unit and review of the literature.
abstract: Horizontal transmission of Candida species in the hospital environment and the fungemia rates have increased in the past decade. We describe a nosocomial cluster of fungemia caused by Candida pelliculosa (teleomorph Pichia anomala) in four infants hospitalized in the pediatric intensive care unit. Candida isolates had strictly related fingerprints, as generated by randomly amplified polymorphic DNA analysis using five different primer sets. The four babies were all treated successfully and recovered. All of the isolates were susceptible to the antifungals tested including amphotericin B, flucytosine, fluconazole, miconazole, micafungin, itraconazole, and voriconazole. Infection control procedures were adapted in the unit and no relapse was detected. In addition, 30 publications presenting 450 pediatric and 28 adult cases are reviewed.
authors.affiliation: Department of Microbiology, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: Ayşe
authors.initials: A
authors.lastname: Kalkanci
authors.forename: Murat
authors.initials: M
authors.lastname: Dizbay
authors.forename: Ozden
authors.initials: O
authors.lastname: Turan
authors.forename: Işil
authors.initials: I
authors.lastname: Fidan
authors.forename: Burçe
authors.initials: B
authors.lastname: Yalçin
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Hirfanoğlu
authors.forename: Semra
authors.initials: S
authors.lastname: Kuştimur
authors.forename: Firdevs
authors.initials: F
authors.lastname: Aktaş
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugita
mesh_terms: D002175:Candida / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification; D002177:Candidiasis / Q000453:epidemiology / Q000635:transmission*; D016000:Cluster Analysis; D003428:Cross Infection / Q000453:epidemiology / Q000635:transmission*; D016469:Fungemia / Q000453:epidemiology / Q000382:microbiology / Q000635:transmission*; D006801:Humans; D007231:Infant, Newborn; D017053:Infection Control / Q000379:methods; D015278:Intensive Care Units, Pediatric; D007564:Japan / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D017422:Sequence Analysis, DNA