Association between serum ferritin and goitre in Iranian school children.
Despite long-standing supplementation of iodine in Iran, the prevalence of goitre among general people remains high in some regions. The study investigated the role of iron status in the aetiology of goitre in school children in Isfahan, Iran. Two thousand three hundred and thirty-one school children were selected by multi-stage random sampling. Thyroid size was estimated by inspection and palpation. Urinary iodine concentration (UIC) and serum ferritin (SF) were measured. Overall, 32.9% of the children had goitre. The median UIC was 195.5 microg/L. The mean +/- SD of SF in the goitrous and non-goitrous children was 47.65 +/- 42.51 and 44.55 +/- 37.07 microg/L respectively (p=0.52). The prevalence of iron deficiency in goitrous and non-goitrous children was 9.6% and 3.1% respectively (p=0.007). Goitre is still prevalent in school children of Isfahan. However, their median UIC was well in the accepted range. Iron deficiency is associated with goitre in a small group of goitrous children. The role of goitrogens should also be investigated in this region.
Hashemipour
Mahin
M
Isfahan Endocrine and Metabolism Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Soheilipour
Fahimeh
F
Keshteli
Ammar Hassanzadeh
AH
Siavash
Mansour
M
Amini
Masoud
M
Kelishadi
Roya
R
D015415:Biomarkers / Q000097:blood / Q000652:urine; D002648:Child; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D005293:Ferritins / Q000097:blood* / Q000172:deficiency; D006042:Goiter / Q000097:blood* / Q000453:epidemiology* / Q000652:urine; D006801:Humans; D007455:Iodine / Q000652:urine; D007492:Iran / Q000453:epidemiology; D007501:Iron / Q000097:blood / Q000652:urine; D000090463:Iron Deficiencies; D008297:Male; D009929:Organ Size; D015995:Prevalence; D013961:Thyroid Gland
D015415:Biomarkers; D005293:Ferritins; D007455:Iodine; D007501:Iron
Eur J Clin Nutr. 1990 Jan;44(1):17-22
2354688
Am J Clin Nutr. 1969 Dec;22(12):1584-8
5362485
J Nutr. 1998 Aug;128(8):1401-8
9687562
Eur J Endocrinol. 2002 Dec;147(6):747-53
12457449
Am J Clin Nutr. 1990 Nov;52(5):813-9
2239756
Int J Vitam Nutr Res. 2002 Oct;72(5):296-9
12463104
Br J Nutr. 1993 Sep;70(2):593-607
8260484
Biomed Environ Sci. 1996 Sep;9(2-3):348-57
8886349
Clin Chem. 1996 Feb;42(2):239-43
8595717
Am J Clin Nutr. 2004 Nov;80(5):1283-90
15531677
Arch Iran Med. 2008 Mar;11(2):157-61
18298292
Biol Trace Elem Res. 2009 Summer;129(1-3):70-7
19093076
Am J Clin Nutr. 2000 Jan;71(1):88-93
10617951
Lancet. 1996 Feb 24;347(9000):552-3
8596306
Asia Pac J Clin Nutr. 2006;15(1):50-5
16500878
J Endocrinol Invest. 2002 May;25(5):409-13
12035935
J Biol Chem. 1984 Aug 25;259(16):10053-9
6432778
Am J Clin Nutr. 2002 Apr;75(4):743-8
11916762
Int J Food Sci Nutr. 2009;60 Suppl 5:19-27
19115122
Int J Vitam Nutr Res. 2004 Mar;74(2):103-15
15255447
Am J Physiol. 1980 Nov;239(5):R377-81
7435650
Eur J Endocrinol. 2000 Mar;142(3):217-23
10700714
Horm Res. 2006;66(1):45-50
16710096
J Nutr. 2002 Jul;132(7):1951-5
12097675
J Endocrinol Invest. 2004 Jun;27(6):516-22
15717647
Eur J Endocrinol. 2000 Dec;143(6):727-31
11124854
Endocr Pract. 2001 Mar-Apr;7(2):95-8
11421552