Clinical and virological features of Dengue in Vietnamese infants.
BACKGROUND
Infants account for a small proportion of the overall dengue case burden in endemic countries but can be clinically more difficult to manage. The clinical and laboratory features in infants with dengue have not been extensively characterised.


RESULTS
This prospective, cross-sectional descriptive study of infants hospitalized with dengue was conducted in Vietnam from November 2004 to December 2007. More than two-thirds of 303 infants enrolled on clinical suspicion of dengue had a serologically confirmed dengue virus (DENV) infection. Almost all were primary dengue infections and 80% of the infants developed DHF/DSS. At the time of presentation and during hospitalization, the clinical signs and symptoms in infants with dengue were difficult to distinguish from those with other febrile illnesses, suggesting that in infants early laboratory confirmation could assist appropriate management. Detection of plasma NS1 antigen was found to be a sensitive marker of acute dengue in infants with primary infection, especially in the first few days of illness.


CONCLUSIONS
Collectively, these results provide a systematic description of the clinical features of dengue in infants and highlight the value of NS1 detection for diagnosis.
Chau
Tran Nguyen Bich
TN
Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Anders
Katherine L
KL
Lien
Le Bich
le B
Hung
Nguyen Thanh
NT
Hieu
Lu Thi Minh
LT
Tuan
Nguyen Minh
NM
Thuy
Tran Thi
TT
Phuong
Le Thi
le T
Tham
Nguyen Thi Hong
NT
Lanh
Mai Ngoc
MN
Farrar
Jeremy J
JJ
Whitehead
Stephen S
SS
Simmons
Cameron P
CP
D000328:Adult; D003430:Cross-Sectional Studies; D003715:Dengue / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D003716:Dengue Virus / Q000302:isolation & purification*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014744:Vietnam; D017361:Viral Nonstructural Proteins / Q000097:blood; D055815:Young Adult
D017361:Viral Nonstructural Proteins
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