title: Three new indole alkaloids from Trigonostemon lii.
abstract: Three unprecedented indole alkaloids, trigonoliimines A-C (1-3) with a unique polycyclic system, were isolated from the leaves of Trigonostemon lii Y. T. Chang. The structures of 1-3 were determined by the spectroscopic, computational, and CD exciton chirality approaches. Trigonoliimine A showed modest anti-HIV-1 activity (EC(50) = 0.95 microg/mL, TI = 7.9).
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PRC.
authors.forename: Cheng-Jian
authors.initials: CJ
authors.lastname: Tan
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: Di
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yi-Kang
authors.initials: YK
authors.lastname: Si
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Suo
authors.initials: S
authors.lastname: Gao
authors.forename: Xu-Jia
authors.initials: XJ
authors.lastname: Hu
authors.forename: Xin
authors.initials: X
authors.lastname: Fang
authors.forename: Shi-Fei
authors.initials: SF
authors.lastname: Li
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019665:Euphorbiaceae / Q000737:chemistry*; D015497:HIV-1 / Q000187:drug effects; D026121:Indole Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D018515:Plant Leaves / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D019380:Anti-HIV Agents; D026121:Indole Alkaloids; C551376:trigonoliimine A; C551378:trigonoliimine B; C551377:trigonoliimine C