title: Alterations of decision making and underlying neural correlates after resection of a mediofrontal cortical dysplasia: A single case study.
abstract: We investigated the impact of a congenital prefrontal lesion and its resection on decision making under risk and under ambiguity in a patient with right mediofrontal cortical dysplasia. Both kinds of decision making are normally associated with the medial prefrontal cortex. We additionally studied pre- and postsurgical fMRI activations when processing information relevant for risky decision making. Results indicate selective impairments of ambiguous decision making pre- and postsurgically. Decision making under risk was intact. In contrast to healthy subjects the patient exhibited no activation within the dysplastic anterior cingulate cortex but left-sided orbitofrontal activation on the fMRI task suggesting early reorganization processes.
authors.affiliation: Mara Hospital, Bethel Epilepsy Center, MRI Unit, Bielefeld, Germany. labudda@uni-bielefeld.de
authors.forename: Kirsten
authors.initials: K
authors.lastname: Labudda
authors.forename: Matthias
authors.initials: M
authors.lastname: Brand
authors.forename: Markus
authors.initials: M
authors.lastname: Mertens
authors.forename: Alois
authors.initials: A
authors.lastname: Ebner
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Markowitsch
authors.forename: Friedrich G
authors.initials: FG
authors.lastname: Woermann
mesh_terms: D001288:Attention / Q000502:physiology; D001931:Brain Mapping; D000077463:Carbamide Peroxide; D003072:Cognition Disorders / Q000209:etiology*; D003657:Decision Making / Q000502:physiology*; D056344:Executive Function / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007360:Intelligence; D008279:Magnetic Resonance Imaging / Q000379:methods; D054220:Malformations of Cortical Development / Q000150:complications* / Q000473:pathology / Q000601:surgery; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology; D010545:Peroxides / Q000097:blood; D010775:Photic Stimulation; D016896:Treatment Outcome; D014508:Urea / Q000031:analogs & derivatives / Q000097:blood
chemical_list: D010545:Peroxides; D000077463:Carbamide Peroxide; D014508:Urea