[Analysis of risk factors for low bone mineral density in patients with inflammatory bowel disease].
OBJECTIVE
Several clinical risk factors for low bone mineral density (BMD) in the patients with inflammatory bowel disease (IBD) have been suggested. However, its prevalence and pathophysiology in Korean population have not been fully studied. The aim of this study was to investigate the prevalence and risk factors for low BMD in Korean IBD patient.


METHODS
BMD of the lumbar spine and femur was evaluated using dual-energy X-ray absorptiometry in 30 patients with IBD. Biochemical parameters of bone metabolism, such as serum calcium, phosphorus, osteocalcin, and deoxypyridinoline were measured. The associations between low BMD and clinical parameters such as disease duration, disease activity, drug history, body mass index (BMI), and others were evaluated retrospectively using medical records.


RESULTS
Low BMD at the lumbar spine or femur was observed in 63.3% of the patients, and there was no significant difference between the patients with Crohns disease and ulcerative colitis. Clinical and biochemical parameters were irrelevant to BMD. In the patients without glucocorticoid treatment prior to BMD measurement, already 50.0% of patients had low BMD.


CONCLUSIONS
Low BMD is a common feature in Korean IBD patients, even those who do not use glucocorticoid. The multiple factors may be involved in the pathogenesis of low BMD. Therefore, BMD should be examined in all IBD patients, irrespective of glucocorticoid treatment.
Park
Jae Jung
JJ
Department of Internal Medicine, Ewha Womans University School of Medicine, Ewha Medical Research Institute, Seoul, Korea.
Jung
Sung Ae
SA
Noh
Young Wook
YW
Kang
Min Jung
MJ
Jung
Ji Min
JM
Kim
Seong Eun
SE
Jung
Hye Kyung
HK
Shim
Ki Nam
KN
Kim
Tae Hun
TH
Yoo
Kwon
K
Moon
Il Hwan
IH
Hong
Young Sun
YS
D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000097:blood; D015992:Body Mass Index; D015519:Bone Density; D002118:Calcium / Q000097:blood; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000000981:diagnostic imaging; D003424:Crohn Disease / Q000175:diagnosis / Q000000981:diagnostic imaging; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010758:Phosphorus / Q000097:blood; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors
D000596:Amino Acids; D005938:Glucocorticoids; D015675:Osteocalcin; D010758:Phosphorus; C036020:deoxypyridinoline; D002118:Calcium