title: Early outcomes and improvement of patients with juvenile idiopathic arthritis enrolled in a Canadian multicenter inception cohort.
abstract: OBJECTIVE
  To determine early outcomes and early improvements in a prospective inception cohort of children with juvenile idiopathic arthritis (JIA) treated with current standard therapies.
  
  
  METHODS
  Patients selected were enrolled in an inception cohort of JIA, the Research in Arthritis in Canadian Children Emphasizing Outcomes Study. The juvenile rheumatoid arthritis core criteria set measures were completed at enrollment and 6 months later. Frequencies of normal values for each of the core set measures and the American College of Rheumatology (ACR) Pediatric 30, 50, and 70 (Pedi 70) criteria response rates achieved at 6 months after enrollment were calculated for each JIA-onset subtype group.
  
  
  RESULTS
  Among 354 patients in the study, the median interval between diagnosis and enrollment was 0.7 months. At 6 months after enrollment, median values of active joint counts were highest in patients with rheumatoid factor (RF)-positive polyarthritis (4) and RF-negative polyarthritis (2), but were 0 or 1 for other subtypes. Fifty percent or more of patients with oligoarthritis, systemic arthritis, enthesitis-related arthritis, and undifferentiated arthritis had no active joints, and the ACR Pedi 70 criteria response rate was 48% or more in those with oligoarthritis, RF-negative polyarthritis, and systemic arthritis.
  
  
  CONCLUSIONS
  With current management strategies in clinical practice, improvement in disease activity was noted in considerable proportions of patients in all of the JIA subtype groups, but low levels of disease activity persisted in many. We expect that these early outcomes will prove to be significant predictors of long-term outcomes.
authors.affiliation: University of Manitoba, Winnipeg, Manitoba, Canada. koen@exchange.hsc.mb.ca
authors.forename: Kiem
authors.initials: K
authors.lastname: Oen
authors.forename: Ciarán M
authors.initials: CM
authors.lastname: Duffy
authors.forename: Shirley M L
authors.initials: SM
authors.lastname: Tse
authors.forename: Suzanne
authors.initials: S
authors.lastname: Ramsey
authors.forename: Janet
authors.initials: J
authors.lastname: Ellsworth
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Chédeville
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Chetaille
authors.forename: Claire
authors.initials: C
authors.lastname: Saint-Cyr
authors.forename: David A
authors.initials: DA
authors.lastname: Cabral
authors.forename: Lynn R
authors.initials: LR
authors.lastname: Spiegel
authors.forename: Rayfel
authors.initials: R
authors.lastname: Schneider
authors.forename: Bianca
authors.initials: B
authors.lastname: Lang
authors.forename: Adam M
authors.initials: AM
authors.lastname: Huber
authors.forename: Paul
authors.initials: P
authors.lastname: Dancey
authors.forename: Earl
authors.initials: E
authors.lastname: Silverman
authors.forename: Alan M
authors.initials: AM
authors.lastname: Rosenberg
authors.forename: Bonnie
authors.initials: B
authors.lastname: Cameron
authors.forename: Nicole
authors.initials: N
authors.lastname: Johnson
authors.forename: Jean
authors.initials: J
authors.lastname: Dorval
authors.forename: Rosie
authors.initials: R
authors.lastname: Scuccimarri
authors.forename: Sarah
authors.initials: S
authors.lastname: Campillo
authors.forename: Ross E
authors.initials: RE
authors.lastname: Petty
authors.forename: Karen N Watanabe
authors.initials: KN
authors.lastname: Duffy
authors.forename: Gilles
authors.initials: G
authors.lastname: Boire
authors.forename: Elie
authors.initials: E
authors.lastname: Haddad
authors.forename: Kristin
authors.initials: K
authors.lastname: Houghton
authors.forename: Ronald
authors.initials: R
authors.lastname: Laxer
authors.forename: Stuart E
authors.initials: SE
authors.lastname: Turvey
authors.forename: Paivi
authors.initials: P
authors.lastname: Miettunen
authors.forename: Katherine
authors.initials: K
authors.lastname: Gross
authors.forename: Jaime
authors.initials: J
authors.lastname: Guzman
authors.forename: Susanne
authors.initials: S
authors.lastname: Benseler
authors.forename: Brian M
authors.initials: BM
authors.lastname: Feldman
authors.forename: Victor
authors.initials: V
authors.lastname: Espinosa
authors.forename: Rae S M
authors.initials: RS
authors.lastname: Yeung
authors.forename: Lori
authors.initials: L
authors.lastname: Tucker
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001171:Arthritis, Juvenile / Q000175:diagnosis / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D015796:HLA-B27 Antigen / Q000032:analysis; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D011241:Prednisone / Q000008:administration & dosage; D011446:Prospective Studies; D012217:Rheumatoid Factor / Q000097:blood; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D018501:Antirheumatic Agents; D015796:HLA-B27 Antigen; D012217:Rheumatoid Factor; D011241:Prednisone