Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida.
Four new prenylated flavonoids (1-4), a new stilbenoid (5), and nine known compounds were isolated from the twigs of Artocarpus rigida, collected in Indonesia. The structures of the new compounds were determined by analysis of their spectroscopic data, and the absolute configuration at C-12 of 1 and 2 and the known compounds artonin O (6), artobiloxanthone (7), and cycloartobiloxanthone (8) was determined from their CD and NMR spectroscopic data. Several of the compounds obtained were cytotoxic toward HT-29 human colon cancer cells, with the most potent being compound 2 and the known compounds 6 and 8. Of the substances obtained, compounds 1 and 7 were the most active in the NF-kappaB p50 and p65 assay, respectively.
Ren
Yulin
Y
Division of Medicinal Chemistry and Pharmacognosy and Division of Pharmacy Practice and Administration, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA.
Kardono
Leonardus B S
LB
Riswan
Soedarsono
S
Chai
Heebyung
H
Farnsworth
Norman R
NR
Soejarto
Djaja D
DD
Carcache de Blanco
Esperanza J
EJ
Kinghorn
A Douglas
AD
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031622:Artocarpus / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D007214:Indonesia; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D052002:NF-kappa B p50 Subunit / Q000032:analysis; D018547:Plant Stems / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051996:Transcription Factor RelA / Q000032:analysis
D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D016328:NF-kappa B; D052002:NF-kappa B p50 Subunit; D013267:Stilbenes; D051996:Transcription Factor RelA
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