title: Trichodermaketones A-D and 7-O-methylkoninginin D from the marine fungus Trichoderma koningii.
abstract: Five new polyketide derivatives, 7-O-methylkoninginin D (1) and trichodermaketones A-D (2-5), together with four known compounds, koninginins A, D, E, and F, were isolated from the marine-derived fungus Trichoderma koningii. Trichodermaketones A (2) and B (3) are unprecedented polyketides with a bistetrafuran-containing tricyclic skeleton. The chemical structures and absolute configurations of compounds 1-5 were elucidated by comparing with literature data and extensive spectroscopic methods, including 2D NMR and CD spectroscopic analysis. Compounds 1-5 were evaluated for action against bacteria and fungi and for synergistic antifungal activity. Compound 2 showed synergistic antifungal activity against Candida albicans with 0.05 microg/mL ketoconazole.
authors.affiliation: Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China.
authors.forename: Fuhang
authors.initials: F
authors.lastname: Song
authors.forename: Huanqin
authors.initials: H
authors.lastname: Dai
authors.forename: Yaojun
authors.initials: Y
authors.lastname: Tong
authors.forename: Biao
authors.initials: B
authors.lastname: Ren
authors.forename: Caixia
authors.initials: C
authors.lastname: Chen
authors.forename: Nuo
authors.initials: N
authors.lastname: Sun
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Liu
authors.forename: Jiang
authors.initials: J
authors.lastname: Bian
authors.forename: Mei
authors.initials: M
authors.lastname: Liu
authors.forename: Hong
authors.initials: H
authors.lastname: Gao
authors.forename: Hongwei
authors.initials: H
authors.lastname: Liu
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Chen
authors.forename: Lixin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D007654:Ketoconazole / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014242:Trichoderma / Q000737:chemistry*
chemical_list: C549947:7-O-methylkoninginin D; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001578:Benzopyrans; D018942:Macrolides; D007654:Ketoconazole