Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention.
Tobacco carcinogen and toxicant biomarkers are metabolites or protein or DNA adducts of specific compounds in tobacco products. Highly reliable analytical methods, based mainly on mass spectrometry, have been developed and applied in large studies of many of these biomarkers. A panel of tobacco carcinogen and toxicant biomarkers is suggested here, and typical values for smokers and nonsmokers are summarized. This panel of biomarkers has potential applications in the new and challenging area of tobacco product regulation and in the development of rational approaches to cancer prevention by establishing carcinogen and toxicant uptake and excretion in people exposed to tobacco products.
Hecht
Stephen S
SS
Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA. hecht002@umn.edu
Yuan
Jian-Min
JM
Hatsukami
Dorothy
D
D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism*; D002273:Carcinogens / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000517:prevention & control*; D012907:Smoking / Q000331:legislation & jurisprudence / Q000378:metabolism*; D062789:Tobacco Products
D014408:Biomarkers, Tumor; D002273:Carcinogens
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