title: Evidence of drug confinement into silica mesoporous matrices by STEM spherical aberration corrected microscopy.
abstract: For the first time it has been possible to detect drug molecules confined into the inner part of pore channels of ordered mesoporous materials. This has been possible using spherical aberration correctors incorporated to a STEM microscope, which allows illuminating an individual atom with the electron beam to identify an unknown substance.
authors.affiliation: Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040, Spain. vallet@farm.ucm.es
authors.forename: María
authors.initials: M
authors.lastname: Vallet-Regí
authors.forename: Miguel
authors.initials: M
authors.lastname: Manzano
authors.forename: José M
authors.initials: JM
authors.lastname: González-Calbet
authors.forename: Eiji
authors.initials: E
authors.lastname: Okunishi
mesh_terms: D004164:Diphosphonates / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D000077211:Zoledronic Acid
chemical_list: D004164:Diphosphonates; D007093:Imidazoles; D004364:Pharmaceutical Preparations; C509969:SBA-15; D000077211:Zoledronic Acid; D012822:Silicon Dioxide