title: High risk of sudden death associated with a PRKAG2-related familial Wolff-Parkinson-White syndrome.
abstract: Familial appearance of Wolff-Parkinson-White (WPW) syndrome is rare and displays an autosomal dominant inheritance. Here we report a Chinese kindred of WPW syndrome whose unique clinical features consist of a high risk of sudden cardiac death due to atrial fibrillation, causing a rapid antegrade conduct over the accessory pathway. The mutation in the PRKAG2 gene was identified as responsible for the familial form of WPW syndrome.
authors.affiliation: The Second Hospital of Lanzhou University, Lanzhou, China.
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Zhang
authors.forename: Bin
authors.initials: B
authors.lastname: Hui
authors.forename: Bing-Ren
authors.initials: BR
authors.lastname: Gao
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics*; D002681:China; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D020125:Mutation, Missense; D010375:Pedigree; D014927:Wolff-Parkinson-White Syndrome / Q000150:complications* / Q000235:genetics* / Q000503:physiopathology; D055815:Young Adult
chemical_list: C526223:PRKAG2 protein, human; D055372:AMP-Activated Protein Kinases