Inorganic nanoporous membranes for immunoisolated cell-based drug delivery.
Materials advances enabled by nanotecbnology have brought about promising approaches to improve the encapsulation mechanism for immunoisolated cell-based drug delivery. Cell-based drug delivery is a promising treatment for many diseases but has thus far achieved only limited clinical success. Treatment of insulin dependent diabetes mellitus (IDDM) by transplantation of pancreatic beta-cells represents the most anticipated application ofcell-based drug delivery technology. This review outlines the challenges involved with maintaining transplanted cell viability and discusses how inorganic nanoporous membranes may be useful in achieving clinical success.
Mendelsohn
Adam
A
UCSF/UCB Joint Graduate Group in Bioengineering, University of California, San Francisco, University of California, Berkeley, USA.
Desai
Tejal
T
D000537:Aluminum Oxide / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy; D004339:Drug Compounding; D016503:Drug Delivery Systems; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use; D016381:Islets of Langerhans Transplantation / Q000276:immunology; D008567:Membranes, Artificial; D049329:Nanostructures; D016062:Porosity; D012825:Silicon / Q000737:chemistry / Q000378:metabolism; D014025:Titanium / Q000737:chemistry / Q000378:metabolism
D007166:Immunosuppressive Agents; D007328:Insulin; D008567:Membranes, Artificial; C009495:titanium dioxide; D014025:Titanium; D000537:Aluminum Oxide; D012825:Silicon
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