title: Novel chemoenzymatic methodology for the regioselective glycine loading on polyhydroxy compounds.
abstract: In the present work, we have developed a highly efficient temperature-dependent chemo-enzymatic methodology for the regioselective synthesis of novel esters of glycerol, G1 tri-glycerol dendrons and related esters for the first time using 4-nitrophenyl 2-(tert-butoxycarbonyl)acetate (Boc-gly-Ph-pNO(2)) (2) as the acylating agent. This methodology offers efficient and controlled loading of amino acid (glycine) on polyhydroxy compounds.
authors.affiliation: Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India.
authors.forename: Shashwat
authors.initials: S
authors.lastname: Malhotra
authors.forename: Marcelo
authors.initials: M
authors.lastname: Calderón
authors.forename: Ashok K
authors.initials: AK
authors.lastname: Prasad
authors.forename: Virinder S
authors.initials: VS
authors.lastname: Parmar
authors.forename: Rainer
authors.initials: R
authors.lastname: Haag
mesh_terms: D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D005990:Glycerol / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D005998:Glycine / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D004952:Esters; D005990:Glycerol; D005998:Glycine