Opioid-induced hyperalgesia: low-dose ketamine does work for some orthopaedic problems already.
Griffiths
R
R
D000701:Analgesics, Opioid / Q000009:adverse effects*; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use; D006801:Humans; D006930:Hyperalgesia / Q000517:prevention & control*; D007649:Ketamine / Q000627:therapeutic use*; D019637:Orthopedic Procedures; D010149:Postoperative Pain / Q000517:prevention & control*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors
D000701:Analgesics, Opioid; D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D007649:Ketamine