title: Systems biology in heart diseases.
abstract: Systems biology based on integrative computational analysis and high technology is in a position to construct networks, to study the interactions between molecular components and to develop models of cardiac function and anatomy. Clinical cardiology gets an integrated picture of parameters that are addressed to ventricular and vessel mechanics, cardiac metabolism and electrical activation. The achievement of clinical objectives is based on the interaction between modern technology and clinical phenotype. In this review the need for more sophisticated realization of the structure and function of the cardiovascular system is emphasized while the incorporation of the systems biology concept in predicting clinical phenotypes is a promising strategy that optimize diagnosis and treatment in cardiovascular disease.
authors.affiliation: Cardiology Department, Aristotle University of Thessaloniki, Greece. louridasg@gmail.com
authors.forename: G E
authors.initials: GE
authors.lastname: Louridas
authors.forename: I E
authors.initials: IE
authors.lastname: Kanonidis
authors.forename: K G
authors.initials: KG
authors.lastname: Lourida
references.citation: J Lipid Res. 2006 Nov;47(11):2355-66
references.pmid: 16946414
references.citation: Heart Fail Rev. 2002 Jan;7(1):5-8
references.pmid: 11790918
references.citation: Science. 2002 Nov 8;298(5596):1241-5
references.pmid: 12424381
references.citation: Ann N Y Acad Sci. 2005 Jun;1047:283-95
references.pmid: 16093504
references.citation: Heart Fail Rev. 2010 Jul;15(4):249-50
references.pmid: 19421853
references.citation: Circ Res. 2001 May 25;88(10):984-6
references.pmid: 11375266
references.citation: J Physiol. 1952 Aug;117(4):500-44
references.pmid: 12991237
references.citation: Nature. 2000 Mar 23;404(6776):394-8
references.pmid: 10746727
references.citation: Circ Res. 2000 Sep 29;87(7):E25-36
references.pmid: 11009627
references.citation: Prog Biophys Mol Biol. 2003 May-Jul;82(1-3):229-41
references.pmid: 12732282
references.citation: Science. 1994 Apr 29;264(5159):677-83
references.pmid: 8171319
references.citation: Mol Syst Biol. 2006;2:2006.0031
references.pmid: 16760902
references.citation: Circulation. 2006 May 16;113(19):2335-62
references.pmid: 16702488
references.citation: J Am Coll Cardiol. 2006 Nov 7;48(9):1733-41
references.pmid: 17084242
references.citation: Heart Fail Rev. 2007 Mar;12(1):1-11
references.pmid: 17393305
references.citation: J Mol Cell Cardiol. 2007 Aug;43(2):93-106
references.pmid: 17599348
references.citation: Nucleic Acids Res. 2004 Jan 1;32(Database issue):D463-7
references.pmid: 14681458
references.citation: Nucleic Acids Res. 2007 Jan;35(Database issue):D5-12
references.pmid: 17170002
references.citation: Genes Dev. 2007 May 1;21(9):1010-24
references.pmid: 17473168
references.citation: Biophys J. 2003 Apr;84(4):2734-55
references.pmid: 12668482
references.citation: Prog Biophys Mol Biol. 2004 Jun-Jul;85(2-3):179-95
references.pmid: 15142743
references.citation: Science. 2004 Apr 16;304(5669):445-8
references.pmid: 15031436
references.citation: J Thorac Cardiovasc Surg. 2007 Jan;133(1):210-4
references.pmid: 17198814
references.citation: Proc Natl Acad Sci U S A. 1983 Apr;80(7):1977-81
references.pmid: 6403942
references.citation: Nat Rev Genet. 2004 Feb;5(2):101-13
references.pmid: 14735121
references.citation: Nucleic Acids Res. 2007 Jan;35(Database issue):D21-5
references.pmid: 17202161
references.citation: Science. 1999 Jan 15;283(5400):381-7
references.pmid: 9888852
references.citation: Nat Rev Mol Cell Biol. 2006 Mar;7(3):198-210
references.pmid: 16496022
references.citation: Trends Cardiovasc Med. 2007 Feb;17(2):43-8
references.pmid: 17292045
references.citation: Nature. 1980 Oct 30;287(5785):795-801
references.pmid: 6776413
references.citation: Circ Res. 2004 Dec 10;95(12):1135-6
references.pmid: 15591234
references.citation: J Biomed Discov Collab. 2006 Dec 20;1:19
references.pmid: 17181854
references.citation: Mol Cancer Res. 2002 Dec;1(2):103-12
references.pmid: 12496357
references.citation: Nucleic Acids Res. 2007 Jan;35(Database issue):D193-7
references.pmid: 17142230
references.citation: Nat Rev Genet. 2004 Nov;5(11):811-25
references.pmid: 15520791
references.citation: J Clin Invest. 2004 Mar;113(5):686-93
references.pmid: 14991066
references.citation: Am J Physiol Cell Physiol. 2007 Jan;292(1):C164-77
references.pmid: 16885397
references.citation: Mamm Genome. 2006 Jun;17(6):466-79
references.pmid: 16783628
references.citation: Coron Artery Dis. 2006 Sep;17(6):545-51
references.pmid: 16905967
references.citation: Coron Artery Dis. 2006 May;17(4):351-8
references.pmid: 16707958
references.citation: Methods Mol Biol. 2000;132:301-12
references.pmid: 10547843
references.citation: Sci Am. 2003 May;288(5):60-9
references.pmid: 12701331
references.citation: Circ Res. 2001 May 25;88(10):1053-8
references.pmid: 11375275
references.citation: Circulation. 2007 Jul 31;116(5):e99-109
references.pmid: 17630410
references.citation: Bioinformatics. 2006 Aug 15;22(16):2053-4
references.pmid: 16787974
references.citation: Science. 1999 Oct 15;286(5439):509-12
references.pmid: 10521342
references.citation: Philos Trans R Soc Lond B Biol Sci. 2004 Jun 29;359(1446):857-71
references.pmid: 15306403
references.citation: Mol Diagn Ther. 2007;11(2):83-95
references.pmid: 17397244
references.citation: Nature. 1960 Nov 5;188:495-7
references.pmid: 13729365
references.citation: Anat Rec. 2000 Oct 1;260(2):148-57
references.pmid: 10993952
references.citation: Int J Cardiol. 2004 Nov;97(2):245-9
references.pmid: 15458691
references.citation: Curr Med Chem. 2004 Dec;11(24):3203-18
references.pmid: 15579008
references.citation: Nucleic Acids Res. 2007 Jan;35(Database issue):D760-5
references.pmid: 17099226
references.citation: J Am Coll Cardiol. 2006 Oct 3;48(7):1289-98
references.pmid: 17010784
references.citation: Nucleic Acids Res. 2006 Jan 1;34(Database issue):D411-4
references.pmid: 16381900
references.citation: Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H823-9
references.pmid: 14766671
references.citation: Science. 2000 Mar 24;287(5461):2185-95
references.pmid: 10731132
references.citation: Circ Res. 2001 Apr 27;88(8):763-73
references.pmid: 11325867
references.citation: Nucleic Acids Res. 2007 Jan;35(Database issue):D610-7
references.pmid: 17148474
references.citation: Ann N Y Acad Sci. 2006 Oct;1080:xi-xxiii
references.pmid: 17390423
references.citation: Circ Res. 2004 Dec 10;95(12):1216-24
references.pmid: 15528464
references.citation: JAMA. 2008 Mar 19;299(11):1351-2
references.pmid: 18349096
references.citation: Circ Res. 2003 May 16;92(9):953-61
references.pmid: 12750305
references.citation: J Mol Cell Cardiol. 2008 Mar;44(3):460-9
references.pmid: 18261742
references.citation: Nucleic Acids Res. 2004 Jan 1;32(Database issue):D277-80
references.pmid: 14681412
references.citation: Bioinformatics. 2002;18 Suppl 1:S233-40
references.pmid: 12169552
references.citation: Nucleic Acids Res. 2007 Jan;35(Database issue):D224-8
references.pmid: 17202162
references.citation: Methods Mol Med. 2006;126:157-69
references.pmid: 16930011
references.citation: Trends Biotechnol. 2003 Jun;21(6):255-62
references.pmid: 12788545
references.citation: Circulation. 2006 Dec 12;114(24):2644-54
references.pmid: 17145989
references.citation: Mol Syst Biol. 2007;3:78
references.pmid: 17299415