title: In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses.
abstract: 4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)benzene sulphonamide and its derivatives were evaluated for antiviral activity against Pathogenic viruses such as Hepatitis C Virus and SARS-CoV in Vero and Huh 5-2 cells, respectively. The 5-fluoro derivative inhibited the HCV RNA synthesis at 6 mug/ml, without toxicity at a concentration up to 42 mug/ml in Huh 5-2 cells. Among the compounds tested SPIII-5F exhibits the 45% maximum protection against replication of SARS-CoV in Vero cells.
authors.affiliation: Arulmigu Kalasalingam College of Pharmacy, Krishnankoil - 626 190, India.
authors.forename: P
authors.initials: P
authors.lastname: Selvam
authors.forename: N
authors.initials: N
authors.lastname: Murgesh
authors.forename: M
authors.initials: M
authors.lastname: Chandramohan
authors.forename: E
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authors.lastname: De Clercq
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authors.lastname: Maes
authors.forename: J
authors.initials: J
authors.lastname: Neyts
authors.forename: M V
authors.initials: MV
authors.lastname: Ranst
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