title: CD147 expression in pituitary adenomas and its significance for clinical outcome.
abstract: CD147, a transmembrane glycoprotein member of the immunoglobulin superfamily of receptors, is involved in invasion and angiogenesis of some types of tumors; but its roles and clinicopathologic significance in pituitary adenomas are not clear. Using immunohistochemistry and quantitative reverse transcriptase polymerase chain reaction, we measured the expression of CD147, matrix metalloproteinase-2, and Ki-67 in 74 pituitary adenomas and evaluated the associations of CD147 with matrix metalloproteinase-2, Ki-67 labeling index, clinicopathologic characteristics, and prognosis. The CD147 protein was expressed in 35 (87.5%) of 40 invasive and in 16 (47.1%) of 34 noninvasive pituitary adenomas; and matrix metalloproteinase-2, in 32 (80.0%) and in 14 (41.2%) of 34, respectively. The Ki-67 labeling index was 3.93% +/- 2.48% for invasive samples and 1.32% +/- 1.04% for noninvasive ones. In addition, the expression of CD147 was positively correlated with matrix metalloproteinase-2, Ki-67 labeling index, or both in invasive pituitary adenomas (P< .01 and P< .01, respectively). All of the 4 recurrent adenomas were concurrently positive for CD147 and matrix metalloproteinase-2, and the Ki-67 labeling indexes of all were greater than 3%. Thus, CD147 may play a pivotal role in the development and progression of invasive pituitary adenomas and also be a useful prognostic biomarker.
authors.affiliation: Department of Neurosurgery, Shandong Provincial Hospital, Shandong University, Jinan, 250021, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Qu
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: Meng
authors.initials: M
authors.lastname: Jiang
authors.forename: Tao
authors.initials: T
authors.lastname: Han
authors.forename: Lizhang
authors.initials: L
authors.lastname: Han
authors.forename: Yuanming
authors.initials: Y
authors.lastname: Qu
authors.forename: Guodong
authors.initials: G
authors.lastname: Wang
authors.forename: Dongli
authors.initials: D
authors.lastname: Shi
authors.forename: Guangming
authors.initials: G
authors.lastname: Xu
mesh_terms: D000236:Adenoma / Q000378:metabolism* / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D051926:Basigin / Q000096:biosynthesis* / Q000235:genetics; D014408:Biomarkers, Tumor / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D051926:Basigin; D020778:Matrix Metalloproteinase 2