title: Natural progression of blood-induced joint damage in patients with haemophilia: clinical relevance and reproducibility of three-dimensional gait analysis.
abstract: A major complication in haemophilia is the destruction of joint cartilage because of recurrent intraarticular and intramuscular bleeds. Therefore, joint assessment is critical to quantify the extent of joint damage, which has traditionally been evaluated using both radiological and clinical joint scores. Our study aimed to evaluate the natural progression of haemophilic arthopathy using three-dimensional gait analysis (3DGA) and to assess the reproducibility of this technique. We hypothesized that the musculoskeletal function was relatively stable in patients with haemophilia. Eighteen adults with established haemophilic arthropathies were evaluated twice by 3DGA (mean follow-up: 18 +/- 5 weeks). Unexpectedly, our findings revealed infraclinical deterioration of gait pattern, characterized by a 3.2% decrease in the recovery index, which is indicative of the subject's ability to save energy while walking. A tendency towards modification of segmental joint function was also observed. Gait analysis was sufficiently reproducible with regards to spatiotemporal parameters as well as kinetic, mechanical and energetic gait variables. The kinematic variables were reproducible in both the sagittal and frontal planes. In conclusion, 3DGA is a reproducible tool to assess abnormal gait patterns and monitor natural disease progression in haemophilic patients.
authors.affiliation: Haemostasis and Thrombosis Unit, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Lobet
authors.forename: C
authors.initials: C
authors.lastname: Detrembleur
authors.forename: B
authors.initials: B
authors.lastname: Francq
authors.forename: C
authors.initials: C
authors.lastname: Hermans
mesh_terms: D000328:Adult; D001696:Biomechanical Phenomena / Q000502:physiology; D004185:Disability Evaluation; D018450:Disease Progression; D005684:Gait; D006467:Hemophilia A / Q000150:complications*; D002836:Hemophilia B / Q000150:complications*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D007592:Joint Diseases / Q000209:etiology / Q000503:physiopathology*; D008875:Middle Aged; D015203:Reproducibility of Results; D016138:Walking / Q000502:physiology*; D055815:Young Adult