title: Genome-wide association study of height and body mass index in Australian twin families.
abstract: Human height and body mass index are influenced by a large number of genes, each with small effects, along with environment. To identify common genetic variants associated with these traits, we performed genome-wide association studies in 11,536 individuals composed of Australian twins, family members, and unrelated individuals at approximately 550,000 genotyped SNPs. We identified a single genome-wide significant variant for height (P value=1.06x10(-9)) located in HHIP, a well-replicated height-associated gene. Suggestive levels of association were found for other known genes associated with height (P values<1x10(-6)): ADAMTSL3, EFEMP1, GPR126, and HMGA2; and BMI (P values<1x10(-4)): FTO and MC4R. Together, these variants explain less than 2% of total phenotypic variation for height and 0.5% for BMI.
authors.affiliation: Queensland Statistical Genetics, Genetic Epidemiology and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Australia.
authors.forename: Jimmy Z
authors.initials: JZ
authors.lastname: Liu
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Medland
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Wright
authors.forename: Anjali K
authors.initials: AK
authors.lastname: Henders
authors.forename: Andrew C
authors.initials: AC
authors.lastname: Heath
authors.forename: Pamela A F
authors.initials: PA
authors.lastname: Madden
authors.forename: Alexis
authors.initials: A
authors.lastname: Duncan
authors.forename: Grant W
authors.initials: GW
authors.lastname: Montgomery
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Martin
authors.forename: Allan F
authors.initials: AF
authors.lastname: McRae
mesh_terms: D015992:Body Mass Index; D005190:Family; D005260:Female; D014644:Genetic Variation; D015894:Genome, Human; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D014427:Twins / Q000235:genetics
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