title: Taking the septic patient to the operating room.
abstract: The acutely septic patient is a multifaceted challenge for the anesthetist. Unlike most elective surgery patients, acutely septic patients have severe systemic disease before the physiologic insults of anesthesia and surgery. The decision to operate is usually informed by the urgent or emergent need to correct a severe surgical problem and weighed against the higher risks of morbidity and mortality from the procedure itself. The care of the septic patient in the intensive care unit can help guide operating room management. However, the acuity and time course of intraoperative events, including hemorrhage and drug-induced shock states, compel the anesthetist to respond aggressively with therapies that may or may not be strongly substantiated with long-term data in the intensive care unit setting. The anesthesiologist must place considerations concerning short-term survival from the acute insult of surgery ahead of longer-term considerations.
authors.affiliation: Department of Anesthesia and Critical Care, The University of Chicago Hospitals, 5841 South Maryland Avenue, MC 4028, Chicago, IL 60637, USA. jhofer@dacc.uchicago.edu
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Hofer
authors.forename: Mark E
authors.initials: ME
authors.lastname: Nunnally
mesh_terms: D000138:Acidosis / Q000188:drug therapy; D000309:Adrenal Insufficiency / Q000209:etiology / Q000628:therapy; D000758:Anesthesia; D001786:Blood Glucose / Q000378:metabolism; D001803:Blood Transfusion; D013502:General Surgery; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D016343:Monitoring, Intraoperative; D019148:Neuromuscular Blockade; D010952:Plasma Substitutes; D018805:Sepsis / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*; D012772:Shock, Septic / Q000150:complications / Q000628:therapy
chemical_list: D001786:Blood Glucose; D010952:Plasma Substitutes