title: Saving and empowering young lives in Europe (SEYLE): a randomized controlled trial.
abstract: BACKGROUND
  There have been only a few reports illustrating the moderate effectiveness of suicide-preventive interventions in reducing suicidal behavior, and, in most of those studies, the target populations were primarily adults, whereas few focused on adolescents. Essentially, there have been no randomized controlled studies comparing the efficacy, cost-effectiveness and cultural adaptability of suicide-prevention strategies in schools. There is also a lack of information on whether suicide-preventive interventions can, in addition to preventing suicide, reduce risk behaviors and promote healthier ones as well as improve young people's mental health.The aim of the SEYLE project, which is funded by the European Union under the Seventh Framework Health Program, is to address these issues by collecting baseline and follow-up data on health and well-being among European adolescents and compiling an epidemiological database; testing, in a randomized controlled trial, three different suicide-preventive interventions; evaluating the outcome of each intervention in comparison with a control group from a multidisciplinary perspective; as well as recommending culturally adjusted models for promoting mental health and preventing suicidal behaviors.
  
  
  METHODS
  The study comprises 11,000 adolescents emitted from randomized schools in 11 European countries: Austria, Estonia, France, Germany, Hungary, Ireland, Israel, Italy, Romania, Slovenia and Spain, with Sweden serving as the scientific coordinating center. Each country performs three active interventions and one minimal intervention as a control group. The active interventions include gatekeeper training (QPR), awareness training on mental health promotion for adolescents, and screening for at-risk adolescents by health professionals. Structured questionnaires are utilized at baseline, 3- and 12-month follow-ups in order to assess changes.
  
  
  CONCLUSIONS
  Although it has been reported that suicide-preventive interventions can be effective in decreasing suicidal behavior, well-documented and randomized studies are lacking. The effects of such interventions in terms of combating unhealthy lifestyles in young people, which often characterize suicidal individuals, have never been reported. We know that unhealthy and risk-taking behaviors are detrimental to individuals' current and future health. It is, therefore, crucial to test well-designed, longitudinal mental health-promoting and suicide-preventive interventions by evaluating the implications of such activities for reducing unhealthy and risk behaviors while concurrently promoting healthy ones.
  
  
  BACKGROUND
  The German Clinical Trials Register, DRKS00000214.
authors.affiliation: National Swedish Prevention of Mental Ill-Health and Suicide (NASP), Karolinska Institutet, Stockholm, Sweden. danuta.wasserman@ki.se
authors.forename: Danuta
authors.initials: D
authors.lastname: Wasserman
authors.forename: Vladimir
authors.initials: V
authors.lastname: Carli
authors.forename: Camilla
authors.initials: C
authors.lastname: Wasserman
authors.forename: Alan
authors.initials: A
authors.lastname: Apter
authors.forename: Judit
authors.initials: J
authors.lastname: Balazs
authors.forename: Julia
authors.initials: J
authors.lastname: Bobes
authors.forename: Renata
authors.initials: R
authors.lastname: Bracale
authors.forename: Romuald
authors.initials: R
authors.lastname: Brunner
authors.forename: Cendrine
authors.initials: C
authors.lastname: Bursztein-Lipsicas
authors.forename: Paul
authors.initials: P
authors.lastname: Corcoran
authors.forename: Doina
authors.initials: D
authors.lastname: Cosman
authors.forename: Tony
authors.initials: T
authors.lastname: Durkee
authors.forename: Dana
authors.initials: D
authors.lastname: Feldman
authors.forename: Julia
authors.initials: J
authors.lastname: Gadoros
authors.forename: Francis
authors.initials: F
authors.lastname: Guillemin
authors.forename: Christian
authors.initials: C
authors.lastname: Haring
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Kahn
authors.forename: Michael
authors.initials: M
authors.lastname: Kaess
authors.forename: Helen
authors.initials: H
authors.lastname: Keeley
authors.forename: Dragan
authors.initials: D
authors.lastname: Marusic
authors.forename: Bogdan
authors.initials: B
authors.lastname: Nemes
authors.forename: Vita
authors.initials: V
authors.lastname: Postuvan
authors.forename: Stella
authors.initials: S
authors.lastname: Reiter-Theil
authors.forename: Franz
authors.initials: F
authors.lastname: Resch
authors.forename: Pilar
authors.initials: P
authors.lastname: Sáiz
authors.forename: Marco
authors.initials: M
authors.lastname: Sarchiapone
authors.forename: Merike
authors.initials: M
authors.lastname: Sisask
authors.forename: Airi
authors.initials: A
authors.lastname: Varnik
authors.forename: Christina W
authors.initials: CW
authors.lastname: Hoven
mesh_terms: D000293:Adolescent; D000328:Adult; D003362:Cost-Benefit Analysis; D005060:Europe; D005260:Female; D005500:Follow-Up Studies; D015438:Health Behavior; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D010865:Pilot Projects; D015397:Program Evaluation; D012017:Referral and Consultation; D012309:Risk-Taking; D012572:School Health Services / Q000191:economics; D013405:Suicide / Q000523:psychology; D011795:Surveys and Questionnaires; D000092864:Suicide Prevention
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