[Comparison of in vitro release behavior of proanthocyanidins flexible nanoliposomes and general nanoliposomes].
OBJECTIVE
To prepare flexible proanthocyanidins nanoliposomes, and explore the in vitro release behavior of proanthocyanidins flexible nanoliposomes and general nanoliposomes.


METHODS
Flexible proanthoeyanidins nanoliposomes were prepared proanthocyanidins using a film dispersion method, characterized by transmission electron microscope, and the in vitro release action was studied in different dissolution mediums using dynamic dialyse method with the content of total phenol as index.


RESULTS
The in vitro release of both proanthocyanidins flexible nanoliposomes and general nanoliposomes were in accordance with Weibull distribution.


CONCLUSIONS
Proanthocyanidins flexible nanoliposomes without pressure had similar in vitro release behavior with general nanoliposomes.
Chen
Yanjun
Y
Institute of Chinese Materia Medica, China Academy of Chinese Medical Science, Beijing 100700, China.
Wu
Huibin
H
Yuan
Junlin
J
Shi
Lei
L
Jin
Rixian
R
Liu
Huafeng
H
Xiong
Weizheng
W
Huang
Luqi
L
D016503:Drug Delivery Systems / Q000379:methods*; D008081:Liposomes / Q000737:chemistry / Q000648:ultrastructure; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D044945:Proanthocyanidins / Q000737:chemistry*
D008081:Liposomes; D044945:Proanthocyanidins