title: [First case report of respiratory infection with Rothia aeria].
abstract: A 53-year-old woman was admitted to our hospital with dysbasia and forgetfulness. Her past history included uveitis at age 39. Medical examinations led to a diagnosis of neurosarcoidosis. Although she was treated with prednisolone, her symptoms remained, so she received steroid pulse therapy twice, and administration of azathioprine. In early January 2007, a chest X-ray film showed nodules in the right upper lung that rapidly increased in size and number. A CT scan revealed multiple nodules including cavitary lesions in both lung fields. Examination of bronchial lavage fluid and a transbronchial lung biopsy showed a mycelium-like gram-negative filament. After the treatment with benzylpenicillin for 1 month, her laboratory data and radiological abnormalities markedly ima proved. However, switching to oral administration of amoxicillin caused the regrowth of the nodules. She was retreated with intravenous benzylpenicillin for 8 weeks, followed by oral administration of amoxicillin for 5 months, and her condition completely resolved. The causative organism was identified as Rothia aeria (described in 2004) by 16S rRNA gene sequencing. This is the first report of a case of pulmonary infection with this species.
authors.affiliation: Department of Respiratory Diseases, Hamanomachi Hospital.
authors.forename: Hiroto
authors.initials: H
authors.lastname: Hiyamuta
authors.forename: Nobuko
authors.initials: N
authors.lastname: Tsuruta
authors.forename: Tomomi
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Marie
authors.initials: M
authors.lastname: Satake
authors.forename: Kiyofumi
authors.initials: K
authors.lastname: Ohkusu
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Higuchi
mesh_terms: D000196:Actinomycosis / Q000382:microbiology*; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000382:microbiology*; D008875:Middle Aged; D010400:Penicillin G / Q000627:therapeutic use
chemical_list: D000900:Anti-Bacterial Agents; D000658:Amoxicillin; D010400:Penicillin G