Paeoniflorin ameliorates schistosomiasis liver fibrosis through regulating IL-13 and its signalling molecules in mice.
Treatment of liver fibrosis associated with Schistosoma japonicum ova-induced granulomas remains a challenging proposition. Paeoniflorin (PAE, C23H28O11) has anti-inflammatory, anti-allergic, and immunoregulatory effects and it is commonly used in Chinese Herbal prescriptions to treat hepatic disorders. The present study was carried out to investigate the effects of PAE on hepatic fibrosis of mice infected with S. japonicum and to explore its possible mechanism. Upon pathological examination of PAE-treated mice, the size of egg granuloma, fibrosis scores, the concentration of IL-13 and hydroxyproline in liver were significantly reduced compared with the model mice. In the primary culture of hepatic stellate cells (HSCs), PAE inhibited IL-13-induced collagen synthesis. These results suggested that PAE might alleviate the hepatic granulomas and fibrosis caused by S. japonicum and the inhibitory effect of PAE on hepatic fibrosis might be associated with its ability to decrease the level of IL-13 and to interfere with the IL-13 signalling molecule in HSCs.
Li
Xiaoyue
X
Institute of Clinical Pharmacology, Anhui Medical University, Hefei, China.
Shen
Jilong
J
Zhong
Zhengrong
Z
Peng
Jun
J
Wen
Huiqin
H
Li
Jing
J
Luo
Qingli
Q
Wei
Wei
W
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D001565:Benzoates / Q000494:pharmacology / Q000627:therapeutic use*; D001952:Bridged-Ring Compounds / Q000494:pharmacology / Q000627:therapeutic use*; D002478:Cells, Cultured; D003094:Collagen / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D006099:Granuloma / Q000473:pathology; D055166:Hepatic Stellate Cells / Q000187:drug effects / Q000378:metabolism; D018793:Interleukin-13 / Q000235:genetics / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D039821:Monoterpenes; D029596:Paeonia; D012549:Schistosoma japonicum / Q000187:drug effects / Q000472:pathogenicity*; D012554:Schistosomiasis japonica / Q000150:complications* / Q000188:drug therapy / Q000469:parasitology; D015398:Signal Transduction; D006027:Glycosides
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001565:Benzoates; D001952:Bridged-Ring Compounds; D003094:Collagen; D005960:Glucosides; D018793:Interleukin-13; D039821:Monoterpenes; C015423:peoniflorin; D006027:Glycosides