Hantavirus outbreak associated with laboratory rats in Yunnan, China.
An outbreak of hemorrhagic fever with renal syndrome occurred among students in a college (College A) in Kunming, Yunnan province, China in 2003. Subsequent investigations revealed the presence of hantavirus antibodies and antigens in laboratory rats at College A and two other institutions. Hantavirus antibodies were detected in 15 additional individuals other than the index case in these three locations. Epidemiologic data indicated that the human infections were a result of zoonotic transmission of the virus from laboratory rats. A virus was isolated from rats in College A and the full-length genome sequence revealed that this was a new Hantaan virus isolate, designated strain KY. Sequence analysis of the three genome segments indicated that this new isolate is a reassortant derived from human and rat Hantaan viruses. Further sequence analysis of the medium (M) genome segment revealed that it originated from a recombination event between two rat Hantaan virus lineages.
Zhang
Yunzhi
Y
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People's Republic of China.
Zhang
Hailin
H
Dong
Xingqi
X
Yuan
Junfa
J
Zhang
Huajun
H
Yang
Xinglou
X
Zhou
Peng
P
Ge
Xingyi
X
Li
Yan
Y
Wang
Lin-Fa
LF
Shi
Zhengli
Z
D000818:Animals; D000830:Animals, Laboratory / Q000821:virology*; D001483:Base Sequence; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D004199:Disease Vectors; D018063:Hantaan virus / Q000145:classification / Q000235:genetics*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000032:analysis; D051381:Rats; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D014495:Universities; D055815:Young Adult; D015047:Zoonoses
D012367:RNA, Viral