Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity.
New sugar derivatives of ristocetin were prepared by copper-catalyzed 1,3-dipolar cycloaddition reaction using azido-ristocetin aglycon and various propargyl glycosides. Some of them were found to be active against gram-positive bacteria and showed favorable antiviral activity against the H1N1 subtype of influenza A virus.
Pintér
Gábor
G
Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem tér 1, H-4010 Debrecen, Hungary.
Bereczki
Ilona
I
Batta
Gyula
G
Otvös
Réka
R
Sztaricskai
Ferenc
F
Roth
Erzsébet
E
Ostorházi
Eszter
E
Rozgonyi
Ferenc
F
Naesens
Lieve
L
Szarvas
Mariann
M
Boda
Zoltán
Z
Herczegh
Pál
P
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D012310:Ristocetin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; C488135:ristocetin aglycon; D012310:Ristocetin; D003300:Copper; D004317:Doxorubicin