Gold nanoparticles capped with sulfate-ended ligands as anti-HIV agents.
Gold nanoparticles coated with multiple copies of an amphiphilic sulfate-ended ligand are able to bind the HIV envelope glycoprotein gp120 as measured by surface plasmon resonance (SPR) and inhibit in vitro the HIV infection of T-cells at nanomolar concentrations. A 50% density of sulfated ligands on approximately 2 nm nanoparticles (the other ligands being inert glucose derivatives) is enough to achieve high anti-HIV activities. This result opens up the possibility of tailoring both sulfated ligands and other anti-HIV molecules on the same gold cluster, thus contributing to the development of non-cocktail based multifunctional anti-HIV systems.
Di Gianvincenzo
Paolo
P
Laboratory of GlycoNanotechnology, CIC biomaGUNE/CIBER-BBN, P degrees Miramón 182, San Sebastián E-20009, Spain.
Marradi
Marco
M
Martínez-Avila
Olga María
OM
Bedoya
Luis Miguel
LM
Alcamí
José
J
Penadés
Soledad
S
D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000737:chemistry*; D002460:Cell Line; D004337:Drug Carriers; D006046:Gold / Q000737:chemistry*; D015699:HIV Envelope Protein gp120 / Q000737:chemistry / Q000378:metabolism; D015658:HIV Infections / Q000517:prevention & control; D006801:Humans; D008024:Ligands; D053768:Metal Nanoparticles / Q000737:chemistry*; D013431:Sulfates / Q000737:chemistry*; D020349:Surface Plasmon Resonance
D019380:Anti-HIV Agents; D004337:Drug Carriers; D015699:HIV Envelope Protein gp120; D008024:Ligands; D013431:Sulfates; D006046:Gold