title: Sry-negative XX sex reversal in a French Bulldog.
abstract: Here, we describe a 3-month-old XX male French Bulldog. The diagnosis was based on the clinical signs, gonadal histology and cytogenetic analysis. Additionally, the dog was confirmed to be Sry negative by semi-quantitative reverse transcription polymerase chain reaction (sqRT-PCR). Canine Sry-negative XX sex reversal is a disorder of gonadal development where individuals who have a female karyotype develop testes or ovotestes. To our knowledge, this case is the first XX male sex reversion described in a French Bulldog.
authors.affiliation: Universidad CEU-Cardenal Herrera, Facultad de Veterinaria, Moncada, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Campos
authors.forename: V
authors.initials: V
authors.lastname: Moreno-Manzano
authors.forename: M
authors.initials: M
authors.lastname: García-Roselló
authors.forename: E
authors.initials: E
authors.lastname: García-Roselló
mesh_terms: D000818:Animals; D012734:Disorders of Sex Development / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D004283:Dog Diseases / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D004285:Dogs; D005260:Female; D008297:Male; D051876:Sex-Determining Region Y Protein / Q000032:analysis*; D013737:Testis / Q000473:pathology; D014960:X Chromosome
chemical_list: D051876:Sex-Determining Region Y Protein