title: Click reaction synthesis of carbohydrate derivatives from ristocetin aglycon with antibacterial and antiviral activity.
abstract: New sugar derivatives of ristocetin were prepared by copper-catalyzed 1,3-dipolar cycloaddition reaction using azido-ristocetin aglycon and various propargyl glycosides. Some of them were found to be active against gram-positive bacteria and showed favorable antiviral activity against the H1N1 subtype of influenza A virus.
authors.affiliation: Department of Pharmaceutical Chemistry, University of Debrecen, Egyetem tér 1, H-4010 Debrecen, Hungary.
authors.forename: Gábor
authors.initials: G
authors.lastname: Pintér
authors.forename: Ilona
authors.initials: I
authors.lastname: Bereczki
authors.forename: Gyula
authors.initials: G
authors.lastname: Batta
authors.forename: Réka
authors.initials: R
authors.lastname: Otvös
authors.forename: Ferenc
authors.initials: F
authors.lastname: Sztaricskai
authors.forename: Erzsébet
authors.initials: E
authors.lastname: Roth
authors.forename: Eszter
authors.initials: E
authors.lastname: Ostorházi
authors.forename: Ferenc
authors.initials: F
authors.lastname: Rozgonyi
authors.forename: Lieve
authors.initials: L
authors.lastname: Naesens
authors.forename: Mariann
authors.initials: M
authors.lastname: Szarvas
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Boda
authors.forename: Pál
authors.initials: P
authors.lastname: Herczegh
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000737:chemistry; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D012310:Ristocetin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; C488135:ristocetin aglycon; D012310:Ristocetin; D003300:Copper; D004317:Doxorubicin