Simultaneous determination of ascorbic acid and uric acid by a new modified carbon nanotube-paste electrode using chloromercuriferrocene.
The electrochemical behavior of ascorbic acid (AA) and uric acid (UA) at the surface of a multiwall carbon nanotube-paste electrode (MCNTPE) modified with incorporate chloromercuriferrocene (CMF) was investigated. The voltammetric studies using the MCNTPE/CMF electrode show two well-resolved anodic peaks for AA and UA with a potential difference of 430 mV, revealing the possibility of the simultaneous electrochemical detection of these compounds. The optimum analytical conditions were sought. Linear calibration plots were obtained over the range of 8.0 x 10(-6)-6.9 x 10(-4) M and 2.4 x 10(-6)-6.9 x 10(-4) M with detection limits (3sigma) of 2.6 x 10(-6) and 7.9 x 10(-7) M for AA and UA, respectively. The electrode with the best conditions is applied for selective determination of AA and UA in complex biological and clinical matrices.
Akbari
Reza
R
Analytical Research Laboratory, Department of Chemistry, University of Sistan & Baluchestan, Zahedan, P. O. Box 98155-147, Iran.
Noroozifar
Meissam
M
Khorasani-Motlagh
Mozhgan
M
Taheri
Aboozar
A
D001205:Ascorbic Acid / Q000032:analysis* / Q000097:blood / Q000737:chemistry / Q000652:urine; D002384:Catalysis; D004563:Electrochemistry; D004566:Electrodes; D006801:Humans; D057230:Limit of Detection; D037742:Nanotubes, Carbon / Q000737:chemistry*; D009824:Ointments; D009941:Organomercury Compounds / Q000737:chemistry*; D013997:Time Factors; D014527:Uric Acid / Q000032:analysis* / Q000097:blood / Q000737:chemistry / Q000652:urine
D037742:Nanotubes, Carbon; D009824:Ointments; D009941:Organomercury Compounds; C010077:chloromercuriferrocene; D014527:Uric Acid; D001205:Ascorbic Acid