title: Reduced cerebral blood flow in older men with higher levels of blood pressure.
abstract: OBJECTIVE
  To examine relations of blood pressure (BP) with single photon emission computed tomography (SPECT)-derived estimates of cerebral blood flow in older men and women.
  
  
  METHODS
  Seventy-four stroke and dementia-free, community-dwelling older adults (ages 54-83 years; 68% men; 91% white) free of major medical, neurological, or psychiatric disease, engaged in clinical assessment of resting SBP and DBP, MRI rated for brain atrophy, and brain single photon emission computed tomography (SPECT) studies with computerized coding of cortical and select subcortical regions of interest.
  
  
  RESULTS
  Given significant interactions of BP and sex with respect to multiple SPECT outcomes, sex-stratified multiple regression models were computed. Models were adjusted for age, fasting glucose levels, antihypertensive medication, BMI, and MRI ratings of brain atrophy. In men (n = 50), higher levels of SBP and/or DBP were associated significantly with lower estimates of cerebral perfusion in the right and left frontal, temporal, parietal, and occipital cortex, thalamus, head of caudate, and cingulate cortex accounting for up to 28% of the variance in these measures (P < 0.05). In women (n = 24), higher DBP was related marginally to higher levels of perfusion in the right temporal cortex (P = 0.05).
  
  
  CONCLUSIONS
  Higher resting SBP or DBP was associated with lower levels of cerebral perfusion in otherwise healthy older men, but not women, in the present sample. Reduced cerebral blood flow may play a pathogenic role in increasing risk for stroke, dementia, and/or cognitive decline, particularly among older men with high BP.
authors.affiliation: Department of Psychology, University of Maryland, Baltimore County, Baltimore, MD 21250, USA. waldstei@umbc.edu
authors.forename: Shari R
authors.initials: SR
authors.lastname: Waldstein
authors.forename: David M
authors.initials: DM
authors.lastname: Lefkowitz
authors.forename: Eliot L
authors.initials: EL
authors.lastname: Siegel
authors.forename: William F
authors.initials: WF
authors.lastname: Rosenberger
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Spencer
authors.forename: Carol F
authors.initials: CF
authors.lastname: Tankard
authors.forename: Zorayr
authors.initials: Z
authors.lastname: Manukyan
authors.forename: Evie J
authors.initials: EJ
authors.lastname: Gerber
authors.forename: Leslie
authors.initials: L
authors.lastname: Katzel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003971:Diastole; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D013599:Systole; D015899:Tomography, Emission-Computed, Single-Photon
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