title: Clerodane diterpenoids and prenylated flavonoids from Dodonaea viscosa.
abstract: Repeated column chromatography of the EtOAc-soluble fraction of the aerial parts of Dodonaea viscosa led to the isolation of two new modified clerodanes, methyl dodovisate A (1) and methyl dodovisate B (2), two new prenylated flavonoids, 5,7,4'-trihydroxy-3',5'-di(3-methylbut-2-enyl)-3,6-dimethoxyflavone (10) and 5,7,4'-trihydroxy-3'-(4-hydroxy-3-methylbutyl)-5'-(3-methylbut-2-enyl)-3,6-dimethoxyflavone (11), together with eight known compounds, dodonic acid (3), hautriwaic acid (4), hautriwaic lactone (5), (+)-hardwickiic acid (6), 5alpha-hydroxy-1,2-dehydro-5,10-dihydroprintzianic acid methyl ester (7), strictic acid (8), dodonolide (9), and aliarin (12). The structures of the new compounds were elucidated by spectroscopic data analysis. Compounds 1-9 and 11 were evaluated on larvicidal activity against the fourth-instar larvae of Aedes albopictus and Culex pipens quinquefasciatus.
authors.affiliation: Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, China.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Niu
authors.forename: Dong-Qin
authors.initials: DQ
authors.lastname: Zeng
authors.forename: Chun-Lin
authors.initials: CL
authors.lastname: Long
authors.forename: Ying-Hui
authors.initials: YH
authors.lastname: Peng
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.forename: Ji-Feng
authors.initials: JF
authors.lastname: Luo
authors.forename: Hong-Sheng
authors.initials: HS
authors.lastname: Wang
authors.forename: Ya-Na
authors.initials: YN
authors.lastname: Shi
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Tang
authors.forename: Fu-Wei
authors.initials: FW
authors.lastname: Zhao
mesh_terms: D000330:Aedes / Q000187:drug effects; D000818:Animals; D003465:Culex / Q000187:drug effects; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D029631:Sapindaceae / Q000737:chemistry*
chemical_list: D045785:Diterpenes, Clerodane; D004365:Drugs, Chinese Herbal; D005419:Flavonoids