Mild arming and derivatization of natural products via an In(OTf)3-catalyzed arene iodination.
Iodination of arene-containing natural products employing N-iodosuccinimide catalyzed by In(OTf)(3) at ambient temperature is reported as a versatile and mild method for natural product derivatization amenable to small scale. This process facilitates natural product derivatization of arene moieties for SAR studies, homo- and heterodimerization of natural products, and also conjugation with reporters such as biotin via subsequent metal-mediated coupling reactions.
Zhou
Cong-Ying
CY
Department of Chemistry, P.O. Box 30012, Texas A&M University, College Station, Texas 77842-3012, USA.
Li
Jing
J
Peddibhotla
Satyamaheshwar
S
Romo
Daniel
D
D001688:Biological Products / Q000737:chemistry*; D002384:Catalysis; D007204:Indium / Q000737:chemistry*; D013329:Structure-Activity Relationship; D013388:Succinimides / Q000737:chemistry; D013696:Temperature
D001688:Biological Products; D013388:Succinimides; D007204:Indium; C008155:N-iodosuccinimide