[Clinical study of non-melanoma skin cancer following human organ transplantation].
BACKGROUND
Increasing evidence suggests that non-melanoma skin cancers (NMSC) are the most frequent tumours in transplanted patients. In this study, we present the first Hungarian dermatological screening program to establish the incidence of NMSC after organ transplantations.


METHODS
116 adult, "Caucasian" (white skin) transplanted (kidney, simultaneous-pancreas-kidney) patients (70 male and 46 female) of the Surgical Department of Pécs University were enrolled from September 2008. All patients underwent a a full skin examination by a dermatologist for NMSC as well as a standardized questionnaire was filled in to assess risk factors.


RESULTS
Screening resulted in 16 NMSC (13.8%, median age: 49.3 years, male : female = 1 : 1) diagnoses with a median duration from transplantation of 4.1 years. Histology showed 13 basal cell carcinoma (BBC), 3 squamous cell carcinoma (SCC), with a 4 : 1 ratio of BCC : SCC. Incidence of NMSC was significantly higher on patients who were treated with cyclosporine as immunosuppressant, who had more than 2 sunburns prior to transplantation, or had outdoor workplace ( p < 0.05).


CONCLUSIONS
These data confirm the importance of skin cancer surveillance in transplant recipients via a close cooperation between Transplantation and Dermatological Centres. Our results reflect the international data, except for the BCC : SCC ratio. Further studies needed to elucidate this difference.
Fekecs
Tamás
T
Pécsi Tudományegyetem, Klinikai Központ Bor-, Nemikórtani és Onkodermatológiai Klinika 7624 Pécs Kodály Zoltán út 20. fekecst@hotmail.com
Kádár
Zsolt
Z
Battyáni
Zita
Z
Kalmár-Nagy
Károly
K
Szakály
Péter
P
Wéber
György
G
Horváth
Ors Péter
OP
Ferencz
Andrea
A
D002280:Basal Cell Carcinoma / Q000209:etiology; D002294:Carcinoma, Squamous Cell / Q000209:etiology; D005260:Female; D006258:Head and Neck Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology; D006686:Hobbies; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D015994:Incidence; D016030:Kidney Transplantation / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009790:Occupations; D016377:Organ Transplantation / Q000009:adverse effects*; D016035:Pancreas Transplantation / Q000009:adverse effects; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology; D013471:Sunburn / Q000150:complications; D011795:Surveys and Questionnaires; D013997:Time Factors
D007166:Immunosuppressive Agents