title: Versatile synthesis and micropatterning of nonfouling polymer brushes on the wafer scale.
abstract: In this article, the authors describe new approaches to synthesize and pattern surfaces with poly[oligo(ethylene glycol) methyl methacrylate] (POEGMA) polymer brushes synthesized by surface-initiated atom transfer radical polymerization. These patterned coatings confer "nonfouling" properties protein and cell resistance-to the surface in a biological milieu. The versatile routes for the synthesis of POEGMA demonstrated here offer clear advantages over other techniques previously used in terms of their simplicity, reliability, and ability to pattern large-area substrates. They also demonstrate that POEGMA polymer brushes can be patterned directly by photolithography, plasma ashing, and reactive ion etching to create patterns at the micro- and nanoscale over large areas with high throughput and repeatability, while preserving the protein and cell resistance of the POEGMA brush.
authors.affiliation: Department of Biomedical Engineering, and Center for Biologically Inspired Materials and Material Systems, Duke University, Durham, North Carolina 27708, USA.
authors.forename: Angus
authors.initials: A
authors.lastname: Hucknall
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Simnick
authors.forename: Ryan T
authors.initials: RT
authors.lastname: Hill
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Chilkoti
authors.forename: Andres
authors.initials: A
authors.lastname: Garcia
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Johannes
authors.forename: Robert L
authors.initials: RL
authors.lastname: Clark
authors.forename: Stefan
authors.initials: S
authors.lastname: Zauscher
authors.forename: Buddy D
authors.initials: BD
authors.lastname: Ratner