title: Novel 2-pyrazoline derivatives as potential antibacterial and antifungal agents.
abstract: The 1,3,5-trisubstituted-2-pyrazolines were synthesized by refluxing isoniazid with various substituted diarylchalcones in N,N-dimethylformamide at 120-140 degrees . The physical and spectral data such as M.P., R(f), elemental analysis, IR, NMR and Mass was obtained for the synthesized compounds and the structures were confirmed. The screening of the synthesized compounds for antimicrobial activity was performed against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli and Aspergillus niger.
authors.affiliation: Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, India.
authors.forename: Suvarna
authors.initials: S
authors.lastname: Kini
authors.forename: A M
authors.initials: AM
authors.lastname: Gandhi
references.citation: J Med Chem. 1993 Jan 8;36(1):134-9
references.pmid: 8421279