title: Raman and Raman optical activity of glycosaminoglycans.
abstract: The first Raman optical activity spectra of glycosaminoglycans (GAGs) are reported and exhibited characteristic features specific to the major chemical differences in GAGs (N-, O-sulfation and N-acetylation). Furthermore, the lack of major features between 1050-1150 cm(-1) for heparin and N-acetyl heparin suggests that these molecules do not adopt strongly helical conformations in solution and indicate subtly different solution conformations.
authors.affiliation: School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK.
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Rudd
authors.forename: Rohanah
authors.initials: R
authors.lastname: Hussain
authors.forename: Giuliano
authors.initials: G
authors.lastname: Siligardi
authors.forename: Edwin A
authors.initials: EA
authors.lastname: Yates
mesh_terms: D002236:Carbohydrate Conformation; D006025:Glycosaminoglycans / Q000737:chemistry*; D006493:Heparin / Q000031:analogs & derivatives / Q000737:chemistry; D013059:Spectrum Analysis, Raman
chemical_list: D006025:Glycosaminoglycans; C089591:N-acetylheparin; D006493:Heparin