title: Biomarkers in systemic sclerosis.
abstract: Systemic sclerosis is an autoimmune inflammatory disorder of unknown etiologycharacterized b y pronounced fibroproliferative alterations in the microvasculature, and frequent cellular and humoral immunity abnormalities, culminating in a severe and often progressive fibrotic process. Numerous biomarkers reflecting the three main pathogenetic mechanisms in systemic sclerosis have been described; however, aside from several disease-specific autoantibodies, other biomarkers have not been thoroughly validated and require further study. Thus, there is an unmet need for validated biomarkers for diagnosis, disease classification, and evaluation of organ involvement and therapeutic response in systemic sclerosis.
authors.affiliation: Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, PA 19107-15541, USA. sergio.jimenez@jefferson.edu
authors.forename: Susan V
authors.initials: SV
authors.lastname: Castro
authors.forename: Sergio A
authors.initials: SA
authors.lastname: Jimenez
mesh_terms: D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism; D042783:Endothelial Cells / Q000502:physiology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D007111:Immunity, Cellular; D008954:Models, Biological; D020411:Oligonucleotide Array Sequence Analysis; D040901:Proteomics; D011658:Pulmonary Fibrosis / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism; D012595:Scleroderma, Systemic / Q000145:classification / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D016207:Cytokines
references.citation: Rheumatology (Oxford). 2008 Dec;47(12):1754-60
references.pmid: 18829709
references.citation: Clin Rheumatol. 1990 Mar;9(1 Suppl 1):136-9
references.pmid: 2203592
references.citation: Acta Derm Venereol. 1999 May;79(3):207-10
references.pmid: 10384918
references.citation: Treat Respir Med. 2004;3(6):339-52
references.pmid: 15658881
references.citation: Am J Pathol. 1997 Sep;151(3):831-41
references.pmid: 9284832
references.citation: Rheum Dis Clin North Am. 2003 May;29(2):255-73, vi
references.pmid: 12841294
references.citation: Am J Respir Crit Care Med. 2000 Jul;162(1):258-63
references.pmid: 10903251
references.citation: J Rheumatol. 2001 Nov;28(11):2454-9
references.pmid: 11708418
references.citation: Rheumatol Int. 2008 May;28(7):657-60
references.pmid: 18092166
references.citation: J Rheumatol. 2007 Jan;34(1):104-9
references.pmid: 17117486
references.citation: Br J Rheumatol. 1995 Nov;34(11):1048-54
references.pmid: 8542206
references.citation: Autoimmunity. 2005 Feb;38(1):65-72
references.pmid: 15804707
references.citation: J Rheumatol. 1997 Oct;24(10):1936-43
references.pmid: 9330935
references.citation: J Rheumatol. 2009 Apr;36(4):773-80
references.pmid: 19286849
references.citation: Ann Intern Med. 1981 Apr;94(4 pt 1):482-4
references.pmid: 6782927
references.citation: Ann Rheum Dis. 2008 Jan;67(1):105-9
references.pmid: 17604287
references.citation: J Immunol. 2002 Apr 1;168(7):3649-59
references.pmid: 11907131
references.citation: Clin Chem Lab Med. 2008;46(6):748-63
references.pmid: 18601595
references.citation: J Rheumatol. 2004 Apr;31(4):795-800
references.pmid: 15088311
references.citation: Arthritis Rheum. 2006 Jun;54(6):1961-73
references.pmid: 16736506
references.citation: Rheum Dis Clin North Am. 2008 Feb;34(1):41-55; vi
references.pmid: 18329531
references.citation: Rheumatology (Oxford). 2008 Nov;47(11):1727-8
references.pmid: 18820309
references.citation: Semin Arthritis Rheum. 2007 Oct;37(2):93-8
references.pmid: 17363039
references.citation: Arthritis Rheum. 2007 Jul;56(7):2422-31
references.pmid: 17599771
references.citation: Scand J Rheumatol. 2005 Jul-Aug;34(4):293-7
references.pmid: 16195162
references.citation: Folia Biol (Praha). 2007;53(2):66-8
references.pmid: 17448296
references.citation: J Clin Invest. 2007 Mar;117(3):557-67
references.pmid: 17332883
references.citation: Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12319-24
references.pmid: 14530402
references.citation: Am J Physiol Lung Cell Mol Physiol. 2008 Oct;295(4):L603-11
references.pmid: 18676875
references.citation: J Rheumatol. 2005 Dec;32(12):2477-80
references.pmid: 16331791
references.citation: Hum Pathol. 2006 Feb;37(2):190-7
references.pmid: 16426919
references.citation: Clin Exp Rheumatol. 2003;21(3 Suppl 29):S32-8
references.pmid: 12889220
references.citation: Arthritis Res. 2002;4(6):R11
references.pmid: 12453314
references.citation: J Rheumatol. 2000 Apr;27(4):930-4
references.pmid: 10782818
references.citation: Ann N Y Acad Sci. 2005 Jun;1051:404-12
references.pmid: 16126982
references.citation: Clin Rev Allergy Immunol. 2009 Jun;36(2-3):150-75
references.pmid: 19067252
references.citation: Trends Mol Med. 2008 Jun;14(6):261-7
references.pmid: 18487087
references.citation: Curr Rheumatol Rep. 2006 Apr;8(2):131-7
references.pmid: 16569372
references.citation: Respirology. 2009 Aug;14(6):788-95
references.pmid: 19703061
references.citation: Dermatology. 2000;200(3):196-201
references.pmid: 10828626
references.citation: Arthritis Res Ther. 2003;5(2):80-93
references.pmid: 12718748
references.citation: Curr Opin Rheumatol. 2007 Nov;19(6):561-7
references.pmid: 17917536
references.citation: Clin Exp Rheumatol. 1989 Sep-Oct;7 Suppl 3:S57-62
references.pmid: 2691161
references.citation: J Rheumatol. 2007 Oct;34(10):2056-62
references.pmid: 17896803
references.citation: Clin Exp Rheumatol. 2003 Jul-Aug;21(4):429-36
references.pmid: 12942693
references.citation: J Rheumatol. 2003 Oct;30(10):2147-51
references.pmid: 14528508
references.citation: Pathobiology. 1995;63(1):48-56
references.pmid: 7546275
references.citation: Rheum Dis Clin North Am. 2008 Feb;34(1):73-9; vi
references.pmid: 18329533
references.citation: Eur Respir J. 2010 Jan;35(1):95-104
references.pmid: 19643943
references.citation: Front Biosci (Schol Ed). 2009 Jun 01;1(1):226-35
references.pmid: 19482698
references.citation: Trends Immunol. 2005 Nov;26(11):587-95
references.pmid: 16168711
references.citation: Eur Heart J. 2006 Jun;27(12):1485-94
references.pmid: 16682379
references.citation: Semin Arthritis Rheum. 2005 Aug;35(1):35-42
references.pmid: 16084222
references.citation: Rheumatology (Oxford). 2009 Jun;48 Suppl 3:iii25-31
references.pmid: 19487219
references.citation: Genes Immun. 2009 Apr;10(3):210-8
references.pmid: 19129850
references.citation: Joint Bone Spine. 2006 Oct;73(5):490-4
references.pmid: 16798048
references.citation: Br J Dermatol. 1998 Dec;139(6):1020-5
references.pmid: 9990365
references.citation: Autoimmun Rev. 2003 Jun;2(4):181-91
references.pmid: 12848944
references.citation: J Rheumatol. 2007 Mar;34(3):501-9
references.pmid: 17299843
references.citation: Lab Invest. 2007 Nov;87(11):1077-91
references.pmid: 17724448
references.citation: Arthritis Rheum. 2005 Sep;52(9):2889-96
references.pmid: 16142750
references.citation: Br J Rheumatol. 1995 Sep;34(9):814-9
references.pmid: 7582719
references.citation: J Rheumatol. 1996 Apr;23(4):646-9
references.pmid: 8730120
references.citation: J Rheumatol. 2003 Jan;30(1):68-73
references.pmid: 12508392
references.citation: Autoimmun Rev. 2008 Sep;7(8):588-93
references.pmid: 18617021
references.citation: Arthritis Res Ther. 2007;9(5):R85
references.pmid: 17784951
references.citation: Semin Arthritis Rheum. 2003 Apr;32(5):285-95
references.pmid: 12701039
references.citation: Rheum Dis Clin North Am. 2008 Feb;34(1):57-71; vi
references.pmid: 18329532
references.citation: Nat Rev Rheumatol. 2009 Apr;5(4):200-6
references.pmid: 19337284
references.citation: PLoS One. 2008 Jul 16;3(7):e2696
references.pmid: 18648520
references.citation: Arthritis Res. 2001;3(3):178-82
references.pmid: 11299058
references.citation: Clin Rheumatol. 2008 May;27(5):655-8
references.pmid: 18204995
references.citation: Arthritis Res Ther. 2007;9 Suppl 2:S3
references.pmid: 17767741
references.citation: Clin Exp Rheumatol. 2005 Mar-Apr;23(2):165-72
references.pmid: 15895885
references.citation: Br J Rheumatol. 1998 Nov;37(11):1188-92
references.pmid: 9851267
references.citation: Haematologica. 2003 Aug;88(8):914-8
references.pmid: 12935979
references.citation: Wien Med Wochenschr. 2008;158(1-2):19-28
references.pmid: 18286246
references.citation: Rev Med Interne. 2007 Jun;28(6):371-6
references.pmid: 17291632
references.citation: J Rheumatol. 2007 Feb;34(2):353-8
references.pmid: 17295440
references.citation: Clin Rheumatol. 2005 Apr;24(2):111-6
references.pmid: 15349798
references.citation: Arthritis Rheum. 2007 May;56(5):1685-93
references.pmid: 17469163
references.citation: Ann Rheum Dis. 1996 Feb;55(2):122-7
references.pmid: 8712862
references.citation: Arthritis Rheum. 1995 Feb;38(2):184-9
references.pmid: 7848308
references.citation: Ann Rheum Dis. 2009 Mar;68(3):435-41
references.pmid: 18408251
references.citation: Arthritis Rheum. 2006 Jan;54(1):192-201
references.pmid: 16385515
references.citation: Matrix Biol. 2006 May;25(4):213-22
references.pmid: 16520029
references.citation: Arthritis Rheum. 2005 Mar;52(3):865-76
references.pmid: 15751056
references.citation: Br J Rheumatol. 1989 Apr;28(2):98-103
references.pmid: 2706431
references.citation: Curr Rheumatol Rep. 2007 May;9(2):151-7
references.pmid: 17502046
references.citation: Ann Intern Med. 2004 Jan 6;140(1):37-50
references.pmid: 14706971
references.citation: Clin Exp Rheumatol. 2008 May-Jun;26(3):414-20
references.pmid: 18578962
references.citation: Respir Res. 2004 Nov 30;5:24
references.pmid: 15571627
references.citation: J Rheumatol. 2003 Jul;30(7):1630-47
references.pmid: 12858472
references.citation: N Engl J Med. 2009 May 7;360(19):1989-2003
references.pmid: 19420368
references.citation: Curr Opin Mol Ther. 2007 Dec;9(6):563-71
references.pmid: 18041667
references.citation: Semin Arthritis Rheum. 2004 Aug;34(1):442-53
references.pmid: 15305243
references.citation: Transl Res. 2008 Apr;151(4):197-207
references.pmid: 18355767
references.citation: J Rheumatol. 2003 Jul;30(7):1529-33
references.pmid: 12858453
references.citation: Arthritis Rheum. 2009 Feb;60(2):584-91
references.pmid: 19180499
references.citation: Crit Rev Clin Lab Sci. 2006;43(5-6):497-560
references.pmid: 17050080
references.citation: QJM. 2005 Jul;98(7):485-92
references.pmid: 15955800
references.citation: Rheumatology (Oxford). 2009 Jun;48 Suppl 3:iii40-4
references.pmid: 19487223
references.citation: Rheumatology (Oxford). 2005 Dec;44(12):1518-24
references.pmid: 16159952
references.citation: Rheum Dis Clin North Am. 1996 Nov;22(4):675-94
references.pmid: 8923590
references.citation: Ann Rheum Dis. 2007 Jul;66(7):940-4
references.pmid: 17329309
references.citation: Arthritis Rheum. 2001 Jun;44(6):1363-9
references.pmid: 11407696
references.citation: J Invest Dermatol. 2010 Mar;130(3):694-705
references.pmid: 19812599
references.citation: Arthritis Rheum. 1990 Mar;33(3):375-80
references.pmid: 2317223
references.citation: Rheumatology (Oxford). 2006 Oct;45 Suppl 3:iii8-10
references.pmid: 16987839
references.citation: J Rheumatol. 2008 Jan;35(1):120-5
references.pmid: 18085738
references.citation: J Rheumatol. 1991 Dec;18(12):1826-32
references.pmid: 1795320
references.citation: Ann Rheum Dis. 2008 Sep;67(9):1242-8
references.pmid: 18065498
references.citation: Arthritis Rheum. 1991 Feb;34(2):243-4
references.pmid: 1994925
references.citation: Acta Derm Venereol. 2000 Sep-Oct;80(5):383
references.pmid: 11200843
references.citation: Arthritis Res Ther. 2007;9 Suppl 2:S2
references.pmid: 17767740
references.citation: Arthritis Rheum. 2007 Aug;56(8):2740-6
references.pmid: 17665460
references.citation: Curr Rheumatol Rep. 2002 Apr;4(2):136-42
references.pmid: 11890879
references.citation: Autoimmun Rev. 2009 Jul;8(8):692-6
references.pmid: 19393194
references.citation: Ann Rheum Dis. 2005 Mar;64(3):481-3
references.pmid: 15708899
references.citation: Arthritis Rheum. 2008 Jan;58(1):284-91
references.pmid: 18163505
references.citation: Rheumatology (Oxford). 2008 Jan;47(1):45-9
references.pmid: 18077490