What's so special about RB?
RB, p107, and p130 are highly related proteins, each capable of regulating cellular proliferation. However, only RB is frequently mutated in cancer. In this issue of Cancer Cell, Chicas et al. shed new light on this conundrum, defining a "special," nonredundant role for RB in promoting cellular senescence.
Burd
Christin E
CE
Department of Genetics, The Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7295, USA.
Sharpless
Norman E
NE
D002453:Cell Cycle / Q000502:physiology; D016922:Cellular Senescence; D019927:Cyclin E / Q000378:metabolism; D004249:DNA Damage; D004261:DNA Replication; D006801:Humans; D015513:Oncogene Proteins / Q000378:metabolism; D018384:Oxidative Stress; D056286:Retinoblastoma Binding Proteins / Q000378:metabolism*
C475820:CCNE1 protein, human; D019927:Cyclin E; D015513:Oncogene Proteins; D056286:Retinoblastoma Binding Proteins
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