Antiangiogenic therapy in lung cancer: focus on vascular endothelial growth factor pathway.
Lung cancer (LC) is a leading cause of death worldwide. Recent advances in chemotherapeutic agents have not yielded any significant improvement in the prognosis of patients with LC. The five-year survival rate for all combined disease stages remains about 15%. For this reason, new therapies such as those that inhibit tumor angiogenesis or block activity of growth factor receptors are of special interest in this group of patients. In this review we will summarize the most recent clinical data on biologic therapies that inhibit tumor angiogenesis in LC, focusing on those that are most clinically relevant.
Korpanty
Grzegorz
G
Department of Medical Oncology, Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland. greg.korpanty@gmail.com
Smyth
Elizabeth
E
Sullivan
Laura A
LA
Brekken
Rolf A
RA
Carney
Desmond N
DN
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab; D002289:Carcinoma, Non-Small-Cell Lung / Q000098:blood supply / Q000628:therapy; D002986:Clinical Trials as Topic; D066246:ErbB Receptors / Q000037:antagonists & inhibitors; D006801:Humans; D008175:Lung Neoplasms / Q000098:blood supply* / Q000628:therapy*; D009389:Neovascularization, Pathologic; D010880:Piperidines / Q000627:therapeutic use; D011799:Quinazolines / Q000627:therapeutic use; D040262:Receptors, Vascular Endothelial Growth Factor / Q000037:antagonists & inhibitors; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors*
D020533:Angiogenesis Inhibitors; D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D010880:Piperidines; D011799:Quinazolines; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000068258:Bevacizumab; D066246:ErbB Receptors; D040262:Receptors, Vascular Endothelial Growth Factor; C452423:vandetanib
Clin Adv Hematol Oncol. 2004 Jan;2(1):37-45
16163158
Am J Physiol Lung Cell Mol Physiol. 2006 Jun;290(6):L1183-92
16428272
J Clin Oncol. 2007 Apr 20;25(12):1539-44
17442997
J Clin Oncol. 2008 Jan 1;26(1):60-5
18165641
Am J Physiol Lung Cell Mol Physiol. 2006 Feb;290(2):L209-21
16403941
Curr Opin Mol Ther. 2005 Oct;7(5):493-501
16248285
Nat Rev Cancer. 2002 Oct;2(10):795-803
12360282
Endocr Rev. 2004 Aug;25(4):581-611
15294883
N Engl J Med. 1971 Nov 18;285(21):1182-6
4938153
N Engl J Med. 2006 Mar 2;354(9):980-2; discussion 980-2
16514715
Cancer Res. 2001 Feb 15;61(4):1309-13
11245426
J Clin Oncol. 2008 Aug 20;26(24):4037-8
18711196
Histol Histopathol. 2004 Jan;19(1):37-42
14702169
J Thorac Oncol. 2008 Jun;3(6 Suppl 2):S107-12
18520291
N Engl J Med. 2006 Dec 14;355(24):2542-50
17167137
Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3609-14
9520413
N Engl J Med. 2004 Jun 3;350(23):2335-42
15175435
Am J Kidney Dis. 2007 Feb;49(2):186-93
17261421
Oncologist. 2006 Nov-Dec;11(10):1070-1
17110625
Oncologist. 2004;9 Suppl 1:19-26
15178812
J Thorac Oncol. 2008 Jun;3(6 Suppl 2):S146-9
18520300
Cancer Res. 2005 Jun 1;65(11):4739-46
15930292
J Biol Chem. 1995 Jan 20;270(3):1230-7
7836384
Thorax. 2003 Oct;58(10):892-900
14514947
Science. 2005 Jan 7;307(5706):58-62
15637262
J Clin Oncol. 2007 Sep 20;25(27):4270-7
17878479
N Engl J Med. 2002 Jan 10;346(2):126-8
11784881
J Clin Oncol. 2004 Jun 1;22(11):2184-91
15169807
Science. 1983 Feb 25;219(4587):983-5
6823562
J Clin Oncol. 2007 Oct 20;25(30):4743-50
17909199
Oncologist. 2007 Oct;12(10):1183-93
17962612
J Clin Oncol. 2005 Apr 10;23(11):2544-55
15753462
J Pathol. 1999 Aug;188(4):369-77
10440746
Lung Cancer. 2004 Aug;45(2):137-42
15246183
J Clin Oncol. 1998 Mar;16(3):1207-17
9508209
Curr Drug Discov Technol. 2009 Jun;6(2):91-102
19519336
Nat Rev Cancer. 2007 Jun;7(6):475-85
17522716
J Clin Oncol. 2001 Jan 15;19(2):432-41
11208836
J Clin Oncol. 2009 Mar 10;27(8):1227-34
19188680
N Engl J Med. 2005 Jul 14;353(2):172-87
16014887
Cancer Cell. 2005 Jan;7(1):101-11
15652753
Dev Biol. 2003 Dec 15;264(2):443-55
14651929
Nat Med. 2003 Jun;9(6):669-76
12778165
Drugs R D. 2008;9(4):261-9
18588357
Lung Cancer. 2001 Nov;34(2):233-41
11679182
N Engl J Med. 2004 Jan 22;350(4):379-92
14736930
Nature. 2005 Dec 15;438(7070):967-74
16355214
Br J Cancer. 2002 Jan 21;86(2):244-9
11870514
J Thorac Oncol. 2008 Jun;3(6 Suppl 2):S128-30
18520295
Hematol Oncol Clin North Am. 2004 Oct;18(5):1007-21, viii
15474332
Semin Cancer Biol. 2009 Oct;19(5):338-43
19481151
CA Cancer J Clin. 2007 Jan-Feb;57(1):43-66
17237035
Nature. 1995 Jul 6;376(6535):66-70
7596436
Curr Treat Options Oncol. 2007 Feb;8(1):15-27
17634832
Expert Rev Anticancer Ther. 2009 Jul;9(7):999-1007
19589038