title: Improvement of L: -Lactic Acid Production under Glucose Feedback Controlled Culture by Lactobacillus rhamnosus.
abstract: In this study, a glucose feedback controller had been designed. Under the controller, the glucose concentration in l-lactic acid culture could be automatically controlled at 15 ± 1 g/L. Furthermore, l-lactic acid production by Lactobacillus rhamnosus LA-04-1 in fed-batch culture was significantly increased to 170 g/L l-lactic acid using the controller compared with 130 g/L l-lactic acid in pulse fed-batch and 135 g/L in l-lactic acid constant feed rate fed-batch cultures. The results showed that the controller was effective at glucose control in l-lactic acid culture. The control strategy could also be used in other fermentation processes.
authors.affiliation: Key Laboratory of Bioprocess of Beijing, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, People's Republic of China. lizheng_nx@163.com
authors.forename: Zheng
authors.initials: Z
authors.lastname: Li
authors.forename: JiKe
authors.initials: J
authors.lastname: Lu
authors.forename: Liqiang
authors.initials: L
authors.lastname: Zhao
authors.forename: Kai
authors.initials: K
authors.lastname: Xiao
authors.forename: Tianwei
authors.initials: T
authors.lastname: Tan
mesh_terms: D061249:Batch Cell Culture Techniques / Q000295:instrumentation / Q000379:methods*; D003470:Culture Media / Q000737:chemistry*; D025461:Feedback, Physiological; D005285:Fermentation; D005947:Glucose / Q000032:analysis* / Q000378:metabolism; D019344:Lactic Acid / Q000096:biosynthesis*; D052201:Lacticaseibacillus rhamnosus / Q000378:metabolism*
chemical_list: D003470:Culture Media; D019344:Lactic Acid; D005947:Glucose