Efficient kinetic resolution of racemic 3-nitro-2H-chromene derivatives catalyzed by Takemoto's organocatalyst.
Efficient kinetic resolution of racemic 3-nitro-2H-chromenes by bifunctional thiourea afforded optically active (R)-3-nitro-2H-chromene derivatives with moderate to good enantioselectivities, which simultaneously gave the multifunctional 3,4-diphenyl-3a-nitrobenzopyrano-[3,4-c]-pyrrolidine-1,1-dicarboxylate derivatives with four vicinal chiral carbon centers.
Xie
Jian-Wu
JW
Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, Department of Chemistry and Life Science, Zhejiang Normal University, Jinhua, 321004, China. xiejw@zjnu.cn
Fan
Li-Ping
LP
Su
Hong
H
Li
Xin-Sheng
XS
Xu
Dong-Cheng
DC
D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D007700:Kinetics; D008958:Models, Molecular; D015394:Molecular Structure; D013237:Stereoisomerism; D013890:Thiourea / Q000031:analogs & derivatives / Q000737:chemistry*
C412074:5,7-dimethoxy-2-methyl-2H-benzopyran; D001578:Benzopyrans; D013890:Thiourea