Prognosis of cancer with branch duct type IPMN of the pancreas.
OBJECTIVE
To examine the coexistence of metachronous and synchronous cancer in branch duct intraductal papillary mucinous neoplasms of the pancreas (IPMN).


METHODS
We reviewed the records of 145 patients with branch duct IPMN between January 1991 and April 2008 and assessed the relationship between IPMN and intra- or extra-pancreatic carcinoma and the outcome of IPMN.


RESULTS
The mean observation period was 55.9 +/- 45.3 mo. Among the 145 patients, the frequency of extra-pancreatic cancer was 29.0%. The frequency of gastric cancer, colon cancer, breast cancer, and pancreatic cancer were 25.5%, 15.7%, 13.7%, and 9.8%, respectively. Twenty (13.8%) of the patients died. The cause of death was extra-pancreatic carcinoma in 40%, pancreatic cancer in 25%, IPMN per se in 20%, and benign disease in 15% of the patients.


CONCLUSIONS
The prognosis for IPMN depends not on the IPMN per se, but on the presence of intra- or extra-pancreatic cancer.
Ikeuchi
Nobuhito
N
Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjyuku, Shinjyuku-ku, Tokyo 160-0023, Japan.
Itoi
Takao
T
Sofuni
Atsushi
A
Itokawa
Fumihide
F
Tsuchiya
Takayoshi
T
Kurihara
Toshio
T
Ishii
Kentaro
K
Tsuji
Shujiro
S
Umeda
Junko
J
Moriyasu
Fuminori
F
Tsuchida
Akihiko
A
Kasuya
Kazuhiko
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D016896:Treatment Outcome
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