Cognitive and psychiatric predictors to psychosis in velocardiofacial syndrome: a 3-year follow-up study.
OBJECTIVE
To predict prodromal psychosis in adolescents with velocardiofacial syndrome (VCFS).


METHODS
A total of 70 youth with VCFS, 27 siblings of youth with VCFS, and 25 community controls were followed from childhood (mean age = 11.8 years) into mid-adolescence (mean age = 15.0 years). Psychological tests measuring intelligence, academic achievement, learning/memory, attention, and executive functioning as well as measures of parent and clinician ratings of child psychiatric functioning were completed at both time points.


RESULTS
Major depressive disorder, oppositional defiant disorder, and generalized anxiety disorder diagnoses increased in the VCFS sample. With very low false positive rates, the best predictor of adolescent prodromal psychotic symptoms was parent ratings of childhood odd/eccentric symptoms and child performance on a measure of executive functioning, the Wisconsin Card Sorting Test.


CONCLUSIONS
Similar to the non-VCFS prodromal psychosis literature, a combination of cognitive and psychiatric variables appears to predict psychosis in adolescence. A child with VCFS who screens positive is noteworthy and demands clinical attention.
Antshel
Kevin M
KM
Department of Psychiatry and Behavioral Sciences, State University of New York-Upstate Medical University, Syracuse, NY 13210, USA. AntshelK@upstate.edu
Shprintzen
Robert
R
Fremont
Wanda
W
Higgins
Anne Marie
AM
Faraone
Stephen V
SV
Kates
Wendy R
WR
D000293:Adolescent; D000296:Adolescent Psychiatry; D001008:Anxiety Disorders / Q000150:complications; D001288:Attention; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000150:complications; D015984:Causality; D002648:Child; D002665:Child Psychiatry; D003071:Cognition; D003865:Major Depressive Disorder / Q000150:complications; D004062:DiGeorge Syndrome / Q000150:complications / Q000453:epidemiology* / Q000523:psychology*; D004522:Educational Status; D056344:Executive Function; D005500:Follow-Up Studies; D006801:Humans; D007360:Intelligence / Q000502:physiology; D008568:Memory; D010290:Parents; D011569:Psychiatric Status Rating Scales; D011581:Psychological Tests; D011618:Psychotic Disorders / Q000175:diagnosis / Q000453:epidemiology
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