title: Portal hypertensive gastropathy: correlation with portal hypertension and prognosis in cirrhosis.
abstract: BACKGROUND
  Portal hypertensive gastropathy (PHG) is a common endoscopic finding in patients with cirrhosis. However, the relationship between PHG and portal hypertension is controversial. Furthermore, nothing is known regarding the correlation between PHG and prognosis in patients with cirrhosis.
  
  
  METHODS
  The hepatic venous pressure gradient (HVPG), endoscopic PHG grade, Child-Pugh score, and model for end-stage liver disease (MELD) score were assessed at baseline and were followed prospectively in 331 cirrhotic patients (284 males, 85.8%; mean age, 52.16 ± 9.05 years) from January 2001 to April 2009. The relationship between PHG with HVPG and survival was investigated.
  
  
  RESULTS
  The HVPG was significantly higher in patients with severe PHG than in those with mild or no PHG (absent, 4.9 ± 1.7 mmHg; mild, 10.7 ± 4.1 mmHg; severe, 15.6 ± 4.6 mmHg; P < 0.001). During follow-up, 28 patients (8.5%) died from liver-related disease. In the Cox regression analysis, severe PHG (none and mild vs. severe) (hazard ratio 1.153, 95% confidence interval: 1.048-1.269) showed a significantly high relative risk of mortality, and in the Kaplan-Meier analysis, severe PHG showed a significantly shorter expected survival time than none or mild PHG (median survival time, 77.6 ± 9.6 months in severe PHG; log-rank test, P = 0.030).
  
  
  CONCLUSIONS
  PHG was associated with portal hypertension severity and prognosis in patients with cirrhosis.
authors.affiliation: Department of Internal Medicine and Institute of Basic Medical Science, Yonsei University, Wonju College of Medicine, Wonju, South Korea.
authors.forename: Moon Young
authors.initials: MY
authors.lastname: Kim
authors.forename: Hoon
authors.initials: H
authors.lastname: Choi
authors.forename: Soon Koo
authors.initials: SK
authors.lastname: Baik
authors.forename: Chang Jin
authors.initials: CJ
authors.lastname: Yea
authors.forename: Chan Sik
authors.initials: CS
authors.lastname: Won
authors.forename: Jong Won
authors.initials: JW
authors.lastname: Byun
authors.forename: So Yeon
authors.initials: SY
authors.lastname: Park
authors.forename: Yong Hwan
authors.initials: YH
authors.lastname: Kwon
authors.forename: Jae Woo
authors.initials: JW
authors.lastname: Kim
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Kim
authors.forename: Sang Ok
authors.initials: SO
authors.lastname: Kwon
authors.forename: Young Ju
authors.initials: YJ
authors.lastname: Kim
authors.forename: Seung Hwan
authors.initials: SH
authors.lastname: Cha
authors.forename: Sei Jin
authors.initials: SJ
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications* / Q000401:mortality; D053208:Kaplan-Meier Estimate; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D017082:Portal Pressure / Q000502:physiology; D011379:Prognosis; D011446:Prospective Studies; D013272:Stomach Diseases / Q000209:etiology* / Q000503:physiopathology
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