Efficient methodology for alkylation of vinylnitroso compounds with carbon nucleophiles.
A diverse array of nitrosoalkenes derived from both acyclic and cyclic ketones, as well as aldehydes, via the Denmark protocol using alpha-chloro-O-TBS-oximes can be trapped efficiently in situ by a wide variety of potassium ester enolates to afford conjugate addition products in good yields.
Li
Puhui
P
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802 USA.
Majireck
Max M
MM
Witek
Jason A
JA
Weinreb
Steven M
SM
J Am Chem Soc. 2007 Aug 29;129(34):10342-3
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