Association analysis of TNFR2, VDR, A2M, GSTT1, GSTM1, and ACE genes with rheumatoid arthritis in South Asians and Caucasians of East Midlands in the United Kingdom.
Genetic associations of TNFR2, VDR (Bsm I and Fok I), A2M, GSTT(1), GSTM(1) and ACE in South Asian and Caucasian patients with rheumatoid arthritis (RA) were assessed in this study. DNA samples from South Asians (134 cases, 149 controls) and Caucasians (137 cases, 150 controls) from the East Midlands of the United Kingdom were genotyped for seven polymorphisms. All cases were rheumatoid-factor positive. Significant genetic associations were observed with TNFR2 R-R (OR = 3.16, CI 1.20-9.26, P < 0.05), A2M 1-1 (OR = 2.09, CI 1.21-3.64, P < 0.05) and GST T(1)null (OR = 1.97, CI 1.07-3.68, P < 0.05) among Caucasian patients. In South Asians, VDR Bsm I B-B genotype (OR = 2.08, CI 1.23-3.52, P < 0.05), A2M 2-2 genotype (OR = 3.99, CI 1.19-17.18, P < 0.05), and GST T(1)null genotype (OR = 2.81, CI 1.40-5.77, P < 0.002) genotypes were associated with RA. In the majority of cases, recessive and multiplicative modes of inheritance explained the observed associations. This study demonstrates that ethnicity affects the genetic associations in RA.
Ghelani
Anant M
AM
School of Science and Technology, Teesside University, Tees Valley, Middlesbrough, TS1 3BA, UK. A.Ghelani@tees.ac.uk
Samanta
Ash
A
Jones
Adrian C
AC
Mastana
Sarabjit S
SS
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000201:enzymology / Q000208:ethnology / Q000235:genetics*; D001208:Asia / Q000453:epidemiology / Q000208:ethnology; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D056726:Genetic Association Studies / Q000379:methods*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D018167:Receptors, Calcitriol / Q000235:genetics*; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000235:genetics*; D006113:United Kingdom / Q000453:epidemiology / Q000208:ethnology; D044465:White People / Q000208:ethnology / Q000235:genetics; D000511:alpha-Macroglobulins / Q000235:genetics*
D005982:Glutathione Transferase; D007703:Peptidyl-Dipeptidase A; D018167:Receptors, Calcitriol; D047889:Receptors, Tumor Necrosis Factor, Type II; D000511:alpha-Macroglobulins; C413545:glutathione S-transferase T1
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