Relapsed APL patient with variant NPM-RARalpha fusion responded to arsenic trioxide-based therapy and achieved long-term survival.
The t(5;17)/NPM-RARalpha is the second variant chromosomal translocation in acute promyelocytic leukemia (APL) to be characterized and also the second most plentiful variant translocation. So far, there is a lack of information on the effectiveness of arsenic trioxide (ATO) in relapsed APL with variant RARalpha chimera including t(5;17)/NPM-RARalpha. We report here a long-term survived APL patient with variant NPM-RARalpha fusion who relapsed four times and each time responded well to ATO or ATO-based re-induction therapy. The patient had received a total of more than 3,500 mg of ATO, but showed no obvious arsenic-related toxicities. This case illustrates the long-term efficiency and safety of ATO-based therapy not only in newly diagnosed APL, but also in relapsed APL including those with variant translocations.
Chen
Yan
Y
Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Gu
Ling
L
Zhou
Chenyan
C
Wu
Xueqiang
X
Gao
Ju
J
Li
Qiang
Q
Zhu
Yiping
Y
Jia
Cangsong
C
Ma
Zhigui
Z
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000627:therapeutic use*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D010087:Oxides / Q000627:therapeutic use*; D012008:Recurrence; D012074:Remission Induction
D000970:Antineoplastic Agents; D001152:Arsenicals; C120276:NPM-RARalpha protein, human; D015514:Oncogene Proteins, Fusion; D010087:Oxides; D000077237:Arsenic Trioxide
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