Hemostimualting properties of preparation containing ultralow doses of antibodies to stem cell factor in cytostatic myelosuppression.
Preparation containing ultralow doses of antibodies to stem cell factor considerably activates bone marrow myelopoiesis suppressed by cyclophosphamide. This effect of the preparation is based on stimulation of proliferation of committed hemopoietic precursors and increase in functional activity of adherent elements of hemopoiesis-inducing microenvironment.
Stavrova
L A
LA
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Tomsk.
Zyuz'kov
G N
GN
Simanina
E V
EV
Miroshnichenko
L A
LA
Udut
E V
EV
Khrichkova
T Yu
TY
Skurikhin
E G
EG
Pershina
O V
OV
Ermakova
N N
NN
Firsova
T V
TV
Zhdanov
V V
VV
Dygai
A M
AM
Gol'dberg
E D
ED
D000818:Animals; D000906:Antibodies / Q000276:immunology* / Q000627:therapeutic use*; D001854:Bone Marrow Cells / Q000166:cytology; D006410:Hematopoiesis / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D019089:Stem Cell Factor / Q000276:immunology*; D013234:Stem Cells / Q000187:drug effects
D000906:Antibodies; D019089:Stem Cell Factor