title: Mhc haplotype M3 is associated with early control of SHIVsbg infection in Mauritian cynomolgus macaques.
abstract: The restricted major histocompatibilty complex of Mauritian cynomolgus macaques confers exceptional potential on this species in human immunodeficiency virus (HIV) vaccine development. However, knowledge of the effects of Mhc genetics on commonly used simian immunodeficiency virus (SIV) and simian/human immunodeficiency virus (SHIV) stocks is incomplete. We determined the effect of Mhc haplotypes on SHIVsbg replication kinetics in a cohort of 25 naïve cynomolgus macaques. Haplotype M3 was associated with a 1.58log(10) reduction in viraemia at day 28 post infection (p.i.). Haplotype M6 was associated with elevated SHIVsbg viraemia at days 28 and 56. No significant effect of Mhc class II haplotypes on viral replication was observed. These data emphasise the importance of genetic characterisation of experimental macaques and advance our understanding of host genetic effects in SIV/SHIV models of HIV infection.
authors.affiliation: Division of Retrovirology, National Institute for Biological Standards and Control, Health Protection Agency, Hertfordshire, UK. Edward.Mee@nibsc.hpa.org.uk
authors.forename: E T
authors.initials: ET
authors.lastname: Mee
authors.forename: N
authors.initials: N
authors.lastname: Berry
authors.forename: C
authors.initials: C
authors.lastname: Ham
authors.forename: A
authors.initials: A
authors.lastname: Aubertin
authors.forename: J
authors.initials: J
authors.lastname: Lines
authors.forename: J
authors.initials: J
authors.lastname: Hall
authors.forename: R
authors.initials: R
authors.lastname: Stebbings
authors.forename: M
authors.initials: M
authors.lastname: Page
authors.forename: N
authors.initials: N
authors.lastname: Almond
authors.forename: N J
authors.initials: NJ
authors.lastname: Rose
mesh_terms: D000818:Animals; D005805:Genes, MHC Class I; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D008252:Macaca fascicularis / Q000235:genetics* / Q000276:immunology*; D008436:Mauritius; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000276:immunology*; D019562:Viral Load; D014766:Viremia / Q000235:genetics*; D014779:Virus Replication