Role of hematopoietic cells in the maintenance of chronic human torquetenovirus plasma viremia.
Many aspects of the life cycle of torquetenoviruses (TTVs) are essentially unexplored. In particular, it is still a matter of speculation which cell type(s) replicates the viruses and maintains the generally high viral loads found in the blood of infected hosts. In this study, we sequentially measured the TTV loads in the plasma of four TTV-positive leukemia patients who were strongly myelosuppressed and then transplanted with haploidentical hematopoietic stem cells. The findings provide clear quantitative evidence for an extremely important role of hematopoietic cells in the maintenance of TTV viremia.
Maggi
Fabrizio
F
Virology Section and Retrovirus Centre, Department of Experimental Pathology, University of Pisa, Italy, Via San Zeno, 35-37, 56127 Pisa, Italy. maggif@biomed.unipi.it
Focosi
Daniele
D
Albani
Melania
M
Lanini
Letizia
L
Vatteroni
Maria Linda
ML
Petrini
Mario
M
Ceccherini-Nelli
Luca
L
Pistello
Mauro
M
Bendinelli
Mauro
M
D000328:Adult; D004267:DNA Viruses / Q000254:growth & development* / Q000302:isolation & purification; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000821:virology*; D019562:Viral Load; D014766:Viremia
D004279:DNA, Viral
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