title: Variants in the adiponectin gene and serum adiponectin: the Coronary Artery Development in Young Adults (CARDIA) Study.
abstract: Circulating adiponectin is involved in the atherosclerotic process and has been associated with cardiovascular disease as well as obesity, insulin resistance, metabolic syndrome, and type 2 diabetes. The adiponectin gene (ADIPOQ) encodes the circulating protein adiponectin and affects its expression. Only a small proportion of all known ADIPOQ polymorphisms have been investigated in relation to circulating adiponectin concentrations. Using data from 3,355 African-American and white men and women aged 33-45 at the year 15 examination from the Coronary Artery Development in Young Adults (CARDIA) Study the association between 10 single-nucleotide polymorphisms (SNPs) within ADIPOQ and serum adiponectin was examined using linear regression. SNPs were chosen based on a tagSNP approach. Models were stratified by self-reported race to control for population stratification, and Bonferroni corrected for multiple comparisons. ADIPOQ SNPs rs17300539 (P < 0.0001), rs182052 (P = 0.0013), rs822393 (P = 0.0005), rs9882205 (P = 0.0001), and rs3774261 (P = 0.0001) were strongly associated with serum adiponectin concentrations in whites. In general, there was a dose-response relationship of adjusted mean adiponectin concentrations across genotypes. Only one SNP, rs17300539 was marginally associated with serum adiponectin concentrations (P = 0.0087) in African Americans. Significant interactions were found between waist and rs182052 (P = 0.0029) and between rs9882505 and smoking (P = 0.001) in whites. Many ADIPOQ SNPs have not yet been examined, and additional studies are needed to determine whether these may be functional variants.
authors.affiliation: Department of Family and Preventive Medicine, University of California San Diego, La Jolla, California, USA. cwassel@ucsd.edu
authors.forename: Christina L
authors.initials: CL
authors.lastname: Wassel
authors.forename: James S
authors.initials: JS
authors.lastname: Pankow
authors.forename: David R
authors.initials: DR
authors.lastname: Jacobs
authors.forename: Michael W
authors.initials: MW
authors.lastname: Steffes
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Pamela J
authors.initials: PJ
authors.lastname: Schreiner
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics*; D000328:Adult; D001741:Black or African American / Q000235:genetics*; D002318:Cardiovascular Diseases / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012907:Smoking / Q000208:ethnology / Q000235:genetics*; D055105:Waist Circumference / Q000208:ethnology / Q000235:genetics; D044465:White People / Q000235:genetics*
chemical_list: D052242:Adiponectin
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