title: Cytotoxic and NF-kappaB inhibitory constituents of Artocarpus rigida.
abstract: Four new prenylated flavonoids (1-4), a new stilbenoid (5), and nine known compounds were isolated from the twigs of Artocarpus rigida, collected in Indonesia. The structures of the new compounds were determined by analysis of their spectroscopic data, and the absolute configuration at C-12 of 1 and 2 and the known compounds artonin O (6), artobiloxanthone (7), and cycloartobiloxanthone (8) was determined from their CD and NMR spectroscopic data. Several of the compounds obtained were cytotoxic toward HT-29 human colon cancer cells, with the most potent being compound 2 and the known compounds 6 and 8. Of the substances obtained, compounds 1 and 7 were the most active in the NF-kappaB p50 and p65 assay, respectively.
authors.affiliation: Division of Medicinal Chemistry and Pharmacognosy and Division of Pharmacy Practice and Administration, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: Yulin
authors.initials: Y
authors.lastname: Ren
authors.forename: Leonardus B S
authors.initials: LB
authors.lastname: Kardono
authors.forename: Soedarsono
authors.initials: S
authors.lastname: Riswan
authors.forename: Heebyung
authors.initials: H
authors.lastname: Chai
authors.forename: Norman R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: Djaja D
authors.initials: DD
authors.lastname: Soejarto
authors.forename: Esperanza J
authors.initials: EJ
authors.lastname: Carcache de Blanco
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D031622:Artocarpus / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019073:HT29 Cells; D006801:Humans; D007214:Indonesia; D015394:Molecular Structure; D016328:NF-kappa B / Q000037:antagonists & inhibitors*; D052002:NF-kappa B p50 Subunit / Q000032:analysis; D018547:Plant Stems / Q000737:chemistry; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051996:Transcription Factor RelA / Q000032:analysis
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D016328:NF-kappa B; D052002:NF-kappa B p50 Subunit; D013267:Stilbenes; D051996:Transcription Factor RelA
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