[Genetic risk factors for recurrent abortion and obstetric complications].
Maternal risk factors dominate among younger women with multiple miscarriages. In all patients, genetic variants associated with low plasma mannose binding lectin or thrombophilia affect the prognosis negatively. In women with secondary recurrent miscarriage, the HLA-DRB1*03 allele or homozygocity for a HLA-G14 basepair insertion is more frequent than in controls. In patients with a first-born boy carrying HLA class II alleles restricting recognition of HY antigens, the live-birth rate is low. Women with these risk genes also have an increased risk of delivering children with a low birth weight.
Christiansen
Ole Bjarne
OB
Obstetrisk og Gynaekologisk Afdeling, Arhus Universitetshospital, Aalborg Sygehus, DK-9100 Aalborg, Denmark. olbc@rn.dk
D000026:Abortion, Habitual / Q000209:etiology / Q000235:genetics* / Q000628:therapy; D000328:Adult; D000483:Alleles; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology / Q000235:genetics* / Q000628:therapy; D012307:Risk Factors
D005819:Genetic Markers; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II