title: The effects of Saccharum officinarium (sugar cane) molasses on cytokine secretion by human blood cultures.
abstract: This study investigated the effects of sugar cane molasses on the immune system, using cytokines as biomarkers. Whole blood cultures, stimulated in vitro with endotoxin or PHA, were incubated with various concentrations of molasses. No cell death occurred in whole blood cultures incubated with molasses samples. The addition of molasses (800 microg/mL) to unstimulated whole blood cultures resulted in increased levels of the biomarker of inflammation, Interleukin-6 (P < 0.001) and also the biomarker of humoral immunity, Interleukin-10 (P < 0.001). Molasses addition (800 microg/mL) to unstimulated whole blood cultures has no effect on the cell mediated immunity biomarker, Interferon gamma secretion. Molasses has no effect on Interleukin-6, Interleukin-10 and Interferon gamma secretion in stimulated whole blood cultures. Immunostimulation by molasses requires further investigation as it may have potential health impacts.
authors.affiliation: Department of Medical Bioscience, University of the Western Cape, Bellville, South Africa.
authors.forename: Farzana
authors.initials: F
authors.lastname: Rahiman
authors.forename: Edmund John
authors.initials: EJ
authors.lastname: Pool
mesh_terms: D000917:Antibody Formation; D002454:Cell Differentiation; D016207:Cytokines / Q000097:blood / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008965:Molasses; D031786:Saccharum / Q000737:chemistry*; D018417:Th1 Cells / Q000166:cytology / Q000378:metabolism; D018418:Th2 Cells / Q000166:cytology / Q000378:metabolism
chemical_list: D016207:Cytokines; D007770:L-Lactate Dehydrogenase