HIV-1 and kidney cells: better understanding of viral interaction.
HIV-associated nephropathy (HIVAN) is the most common disease affecting untreated seropositive patients of African descent. Besides genetic (African descent) and HIV-1 infection (environmental), specific host factors such as activation of renin-angiotensin-aldosterone system (RAAS) have also been demonstrated to play a role in the manifestation of HIVAN. The recent identification of MYH9 as susceptible allele is a key step forward in our understanding for the pathogenesis of focal glomerulosclerosis in people of African-American descent. HIV-1 transgenic models have significantly advanced our knowledge base in terms of role of HIV-1 genes in general and individual gene in particular in the development of renal lesions mimicking HIVAN. These studies suggest that viral replication is not needed for the development of renal lesions. Renal biopsy data from HIVAN patients suggest that renal epithelial cells express HIV-1 genes and thus it may be sufficient to invoke HIVAN phenotype in the presence of specific host and genetic factors. On the other hand, immune response to infection may be required to induce HIV-1 associated immune complex kidney disease (HIVICK). Since renal cell lack conventional HIV-1 receptors, HIV-1 entry into renal cells has been a mystery. Recently, non-conventional pathways have been demonstrated to facilitate HIV-1 entry into renal cells in in vitro studies. These include presence of DEC-205 receptors in renal tubular cells and lipid rafts in podocytes. However, HIV-1 entry through these pathways only allows non-productive infection. It appears that the presence of specific genetic and host factors in in vivo conditions may be facilitating the development of the productive HIV-1 infection in kidney cells.
Mikulak
Joanna
J
Feinstein Institute for Medical Research and Long Island Jewish Medical Center, New Hyde Park, NY, USA.
Singhal
Pravin C
PC
D016263:AIDS-Associated Nephropathy / Q000821:virology*; D001741:Black or African American; D000818:Animals; D015703:Antigens, CD / Q000502:physiology; D001057:Apolipoproteins E / Q000502:physiology; D017209:Apoptosis; D002455:Cell Division; D002648:Child; D042783:Endothelial Cells / Q000821:virology; D004847:Epithelial Cells / Q000821:virology; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology / Q000473:pathology / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D054884:Host-Pathogen Interactions; D054298:Human Immunodeficiency Virus Proteins / Q000502:physiology; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000821:virology*; D007684:Kidney Tubules / Q000166:cytology / Q000821:virology; D037181:Lectins, C-Type / Q000502:physiology; D021962:Membrane Microdomains; D050527:Mesangial Cells / Q000821:virology; D051379:Mice; D008822:Mice, Transgenic; D015778:Minor Histocompatibility Antigens; D020409:Molecular Motor Proteins / Q000502:physiology; D018995:Myosin Heavy Chains / Q000502:physiology; D018384:Oxidative Stress; D050199:Podocytes / Q000473:pathology / Q000821:virology; D011956:Receptors, Cell Surface / Q000502:physiology; D014281:Trihexosylceramides / Q000502:physiology; D053586:Virus Internalization
D015703:Antigens, CD; D001057:Apolipoproteins E; C093569:DEC-205 receptor; D054298:Human Immunodeficiency Virus Proteins; D037181:Lectins, C-Type; C103814:MYH9 protein, human; D015778:Minor Histocompatibility Antigens; D020409:Molecular Motor Proteins; D011956:Receptors, Cell Surface; D014281:Trihexosylceramides; C018549:globotriaosylceramide; D018995:Myosin Heavy Chains
Nat Med. 2002 May;8(5):522-6
11984599
J Am Soc Nephrol. 2000 May;11(5):856-867
10770963
J Am Soc Nephrol. 1998 Aug;9(8):1441-7
9697666
J Virol. 1989 Jun;63(6):2527-33
2786088
Kidney Int. 2009 Jun;75(11):1209-1216
19212418
Nephrol Dial Transplant. 2006 Oct;21(10):2809-13
16864598
Am J Physiol Renal Physiol. 2007 Oct;293(4):F1214-21
17652372
Ann Intern Med. 2003 Aug 5;139(3):214-26
12899589
J Biol Chem. 2001 Dec 28;276(52):49142-7
11579084
J Am Soc Nephrol. 2006 Oct;17(10):2832-43
16988066
Ren Fail. 2009;31(4):303-12
19462280
Kidney Int. 2000 Aug;58(2):607-17
10916084
J Immunol. 2002 Jun 15;168(12):6244-52
12055238
Kidney Int. 2008 Oct;74(8):1049-58
18614999
Am J Physiol Renal Physiol. 2001 Feb;280(2):F333-42
11208609
J Biol Chem. 2009 Jun 12;284(24):16648-16658
19383602
Am J Pathol. 2002 Jul;161(1):53-61
12107089
J Am Soc Nephrol. 2002 Jul;13(7):1806-15
12089376
J Am Soc Nephrol. 2007 Mar;18(3):780-7
17287423
Nat Genet. 2008 Oct;40(10):1175-84
18794856
Kidney Int. 1998 May;53(5):1217-29
9573536
J Am Soc Nephrol. 2002 Mar;13(3):630-638
11856766
Kidney Int. 2005 Sep;68(3):1048-60
16105035
J Am Soc Nephrol. 2007 Feb;18(2):515-27
17229913
J Am Soc Nephrol. 1997 Jul;8(7):1140-6
9219164
Kidney Int. 2010 Jan;77(1):72-3; author reply 73-4
20010881
Kidney Int. 2004 Mar;65(3):860-70
14871405
J Clin Invest. 2009 May;119(5):1178-88
19381020
Pediatr Nephrol. 2005 Oct;20(10):1401-9
16047221
Am J Physiol Renal Physiol. 2009 Sep;297(3):F653-61
19553347
Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8356-60
1518869
Nephron Exp Nephrol. 2006;102(1):e30-8
16179804
Histol Histopathol. 2006 Apr;21(4):393-401
16437385
N Engl J Med. 2001 Jun 28;344(26):1979-84
11430327
Kidney Int. 2000 Sep;58(3):1148-59
10972678
J Virol. 2003 Dec;77(23):12865-74
14610207
AIDS. 2005 Nov 18;19(17):1975-80
16260903
EMBO Rep. 2000 Aug;1(2):190-6
11265761
Nephron. 1997;76(3):284-95
9226228
AIDS. 2007 Jan 11;21(2):263-4
17197829