'Safe' photoantimicrobials for skin and soft-tissue infections.
In light of increasing bacterial drug resistance, novel agents and/or modes of bactericidal action are required. In particular, agents that can act at multiple sites within the bacterial cell appear to offer less potential for the development of resistance. This effect may be achieved using combinations of established drugs. Similar effects have been reported as a result of photodynamic antimicrobial action alone. The photoactivation requirement suggests the utility of such agents in light-accessible presentations such as skin and soft-tissue infections. This approach also offers considerable potential in decreasing conventional antibacterial use and allowing the conservation of important life-saving systemic agents.
Wainwright
Mark
M
School of Pharmacy & Biomolecular Science, Liverpool John Moores University, Liverpool L3 3AF, UK. mark_wainwright@hotmail.com
D006801:Humans; D017319:Photosensitizing Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D017192:Skin Diseases, Bacterial / Q000188:drug therapy*; D018461:Soft Tissue Infections / Q000188:drug therapy*
D017319:Photosensitizing Agents