Applications of elastin-like polypeptides in tissue engineering.
Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality. This review presents a basic overview of ELP properties and modifications that are relevant to tissue engineering, as well as a discussion of the application of ELPs to cartilage, intervertebral disc, vascular graft, liver, ocular, and cell sheet engineering.
Nettles
Dana L
DL
Department of Biomedical Engineering, Durham, NC 27708, USA.
Chilkoti
Ashutosh
A
Setton
Lori A
LA
D004549:Elastin / Q000737:chemistry*; D006801:Humans; D010455:Peptides / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods*
D010455:Peptides; D004549:Elastin
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