[Possible role of glucocorticoids in pathogenesis of type II diabetes mellitus].
Etiology and pathogenesis of II type diabetes mellitus remain until now not finally studied. Modern ideas suppose the presence of two fundamental pathophysiologic defects: insulin resistance (IR) and dysfunctions of beta-cells of the pancreas, accompanied by absolute or relative insulin insufficiency. The article presents IR as the adaptive instead of pathological reaction serving for providing the necessary level of substrata of the metabolism--glucose and the free fat acids necessary to increase energy production in a cell. The author offers a new scheme of pathogenesis of II type diabetes mellitus basing probably on hyper production of the glucocorticoids, causing the main clinical and pathophysiological display of II type diabetes mellitus in people with the certain heredity, limiting the adequate energy production in a cell under the keen demands to an organism.
Chernysh
P P
PP
D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000378:metabolism; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism; D005938:Glucocorticoids / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance
D005227:Fatty Acids; D005938:Glucocorticoids; D005947:Glucose