Energotropic effect of succinate-containing derivatives of 3-hydroxypyridine.
Succinate-containing derivatives of 3-hydroxypyridine, mexidol and proxypin, serve as succinate donors for the respiratory chain and contribute to activation of the succinate oxidase pathway of oxidation. Under conditions of hypoxia, these changes promote recovery of aerobic energy production, normalization of intracellular ATP concentration, and development of the antihypoxic effect. Succinate-free analogues of the test compounds exhibit no such properties. Both agents are considered as energotropic substances. The specific effect of these compounds is manifested in direct interaction with the respiratory chain and normalization of ATP synthesis under conditions of hypoxia/ischemia. The test compounds can be used for the correction of energy metabolism disorders during acute oxygen deficiency. Moreover, they can be used for the treatment of associated functional disturbances.
Lukyanova
L D
LD
Laboratory of Bioenergetics, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia. ldluk@mail.ru
Germanova
E L
EL
Tsybina
T A
TA
Chernobaeva
G N
GN
D000255:Adenosine Triphosphate / Q000378:metabolism; D000654:Amobarbital / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D004579:Electron Transport / Q000187:drug effects* / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008314:Malonates / Q000494:pharmacology; D010084:Oxidation-Reduction; D010725:Phosphocreatine / Q000378:metabolism; D010847:Picolines / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013386:Succinates / Q000737:chemistry / Q000494:pharmacology
D000975:Antioxidants; D006993:Hypnotics and Sedatives; D008314:Malonates; D010847:Picolines; D011725:Pyridines; D013386:Succinates; D010725:Phosphocreatine; C070020:emoxypine succinate; C023500:3-hydroxypyridine; D000255:Adenosine Triphosphate; C030290:malonic acid; D000654:Amobarbital