title: Differences among Men and Women with Schizophrenia: A Study of US and Indian Samples.
abstract: OBJECTIVE
  To test the hypothesis that similar differences in psychopathology are present across cultures among men and women with schizophrenia (SZ).
  
  
  METHODS
  Sex based differences were tested systematically in two independent samples from the Northeastern USA and North India using the same procedures. The clinical variables were obtained from five interview instruments.
  
  
  RESULTS
  Among the US participants, the number of significant differences exceeded chance predictions (15/240 variables significant at p<0.02, 6.25%; expected number of significant differences: 5). Similarly, a greater than expected number of variables differed significantly between men and women among the Indian subjects (13/230 differences at p<0.02, 5.65%; expected: 5). One of these variables significantly differed in both samples (lifetime abuse of cannabis). When multivariate analyses were conducted in the combined US and Indian samples sex based differences remained for only four variables: course of the illness, history of inappropriate emotions, marital status and number of children.
  
  
  CONCLUSIONS
  Sex based differences in SZ/schizoaffective disorder are present in the USA and India at greater than chance probabilities. The majority of the variables differ across the samples. The biological underpinnings of these variables need further investigation.
authors.affiliation: Training Program for Psychiatric Genetics in India, Department of Psychiatry, PGIMER-Dr. Ram Manohar Lohia Hospital, Delhi, India.
authors.forename: Pramod
authors.initials: P
authors.lastname: Thomas
authors.forename: Joel
authors.initials: J
authors.lastname: Wood
authors.forename: Abha
authors.initials: A
authors.lastname: Chandra
authors.forename: Vishwajit L
authors.initials: VL
authors.lastname: Nimgaonkar
authors.forename: Smita N
authors.initials: SN
authors.lastname: Deshpande
references.citation: Seishin Shinkeigaku Zasshi. 2002;104(11):1033-54
references.pmid: 12642908
references.citation: Schizophr Bull. 1990;16(2):185-94
references.pmid: 2197713
references.citation: Br J Psychiatry. 1993 May;162:658-64
references.pmid: 8149118
references.citation: Clin Psychol Rev. 1998 Nov;18(7):795-819
references.pmid: 9827322
references.citation: Eur Psychiatry. 2003 Oct;18(6):282-4
references.pmid: 14611922
references.citation: Br J Psychiatry. 1983 Feb;142:145-51
references.pmid: 6839067
references.citation: Am J Psychiatry. 2004 Aug;161(8):1324-33
references.pmid: 15285956
references.citation: Arch Gen Psychiatry. 2003 Jun;60(6):565-71
references.pmid: 12796219
references.citation: Schizophr Res. 1992 Sep;7(3):225-31
references.pmid: 1390401
references.citation: Eur Arch Psychiatry Neurol Sci. 1988 Sep;237(6):351-64
references.pmid: 3053193
references.citation: Int J Soc Psychiatry. 1989 Autumn;35(3):237-44
references.pmid: 2583957
references.citation: Psychol Med. 1993 Nov;23(4):925-40
references.pmid: 8134516
references.citation: Thyroid. 2008 Jul;18(7):747-54
references.pmid: 18631003
references.citation: Compr Psychiatry. 2001 Jul-Aug;42(4):301-5
references.pmid: 11458304
references.citation: Actas Esp Psiquiatr. 2000 Jul-Aug;28(4):219-23
references.pmid: 11116792
references.citation: Acta Psychiatr Scand Suppl. 2000;(407):58-62
references.pmid: 11261642
references.citation: Psychiatry Res. 1989 Jun;28(3):243-53
references.pmid: 2762431
references.citation: Schizophr Res. 2001 Mar 1;47(2-3):141-7
references.pmid: 11278131
references.citation: Schizophr Bull. 1990;16(2):293-307
references.pmid: 2374885
references.citation: Schizophr Res. 2007 May;92(1-3):41-9
references.pmid: 17350224
references.citation: Arch Gen Psychiatry. 1991 Aug;48(8):764-70
references.pmid: 1883262
references.citation: Schizophr Bull. 1989;15(4):559-71
references.pmid: 2623438
references.citation: Neuro Endocrinol Lett. 2003 Jun-Aug;24(3-4):141-7
references.pmid: 14523347
references.citation: Schizophr Bull. 1992;18(4):701-15
references.pmid: 1359633
references.citation: J Coll Physicians Surg Pak. 2005 Jun;15(6):345-8
references.pmid: 15924839
references.citation: Schizophr Res. 1992 Apr;7(1):65-70
references.pmid: 1591198
references.citation: Endocr J. 2007 Feb;54(1):71-6
references.pmid: 17102569
references.citation: Soc Psychiatry Psychiatr Epidemiol. 2004 Dec;39(12):1017-22
references.pmid: 15583911
references.citation: Arch Gen Psychiatry. 1994 Nov;51(11):849-59; discussion 863-4
references.pmid: 7944874
references.citation: World Psychiatry. 2008 Oct;7(3):173-6
references.pmid: 18836543
references.citation: Acta Psychiatr Scand. 2002 Nov;106(5):337-42
references.pmid: 12366467
references.citation: Brain Res. 2007 Oct 10;1173:84-91
references.pmid: 17765209
references.citation: Schizophr Res. 1996 Dec 15;22(3):215-22
references.pmid: 9000318
references.citation: Acta Psychiatr Scand. 1991 Apr;83(4):307-13
references.pmid: 2028808
references.citation: Arch Gen Psychiatry. 1976 Jun;33(6):766-71
references.pmid: 938196
references.citation: Schizophr Bull. 1989;15(3):431-40
references.pmid: 2683040
references.citation: Compr Psychiatry. 1989 May-Jun;30(3):197-208
references.pmid: 2567229
references.citation: Psychiatr Serv. 2003 Oct;54(10):1407-9
references.pmid: 14557530
references.citation: Soc Psychiatry Psychiatr Epidemiol. 2004 May;39(5):369-74
references.pmid: 15133593
references.citation: Br J Psychiatry. 1994 May;164(5):625-9
references.pmid: 7921712
references.citation: Schizophr Res. 1995 Jan;14(2):105-12
references.pmid: 7710990
references.citation: J Nerv Ment Dis. 1995 Aug;183(8):522-8
references.pmid: 7643064
references.citation: Psychol Med. 1998 Mar;28(2):351-65
references.pmid: 9572092
references.citation: Schizophr Bull. 1990;16(2):211-27
references.pmid: 2197714
references.citation: Schizophr Res. 1990 May-Jun;3(3):159-72
references.pmid: 2278981
references.citation: Psychoneuroendocrinology. 2003 Apr;28 Suppl 2:1-16
references.pmid: 12650679
references.citation: Acta Psychiatr Scand Suppl. 2000;401:3-38
references.pmid: 10887978
references.citation: Am J Psychiatry. 1992 Aug;149(8):1070-4
references.pmid: 1636807
references.citation: Schizophr Res. 2004 Jun 1;68(2-3):387-94
references.pmid: 15099620
references.citation: Schizophr Bull. 1998;24(3):489-93
references.pmid: 9718640
references.citation: Schizophr Bull. 2002;28(2):351-62
references.pmid: 12693440