The complete genome sequence and molecular analysis of human hepatitis E virus genotype IV identified from a Korean patient.
Hepatitis E virus (HEV) was originally identified as the etiological agent of non-HAV enterically transmitted hepatitis. One HEV strain (FJ763142) was identified from an acute viral hepatitis E patient with IgM anti-HEV in Korea. The complete genome sequence consisted of 7,238 nucleotides (nt) plus a 22-nt poly(A) tail. The strain belongs to genotype IV, with 91% homology compared with AB197674, which was found in a Japanese patient who had traveled to China. This finding suggests that HEV genotype IV already circulates in Korea, and this HEV might be the first example of an indigenous strain.
Yun
Haesun
H
Division of Enteric and Hepatitis Viruses, Center for Infectious Diseases, Korea National Institute of Health, Nokbun-dong, Eunpyung-gu, Seoul, Republic of Korea. suni93@hanmail.net
Kim
Jin Seon
JS
Lee
Hyeok Jin
HJ
Jeong
Sook Hyang
SH
Kim
Jeong Sim
JS
Park
Sang Jong
SJ
Hwang
Seong Gyu
SG
Kang
Sook Kyoung
SK
Jee
Youngmee
Y
Kim
Jong Hyun
JH
D000818:Animals; D001483:Base Sequence; D005260:Female; D016679:Genome, Viral; D005838:Genotype; D016751:Hepatitis E / Q000821:virology*; D016752:Hepatitis E virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007723:Korea; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D017422:Sequence Analysis, DNA