Efficacy of anakinra treatment in a patient with colchicine-resistant familial Mediterranean fever.
Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by self-limited recurrent attacks of fever and serositis. The serious complication of FMF is AA-type amyloidosis, which can result in end-stage renal disease. Although colchicine is effective in the majority of patients, there is no established treatment for those who are resistant or intolerant to colchicine. We herein report the efficacy of anakinra in a 52-year-old Turkish patient with FMF, secondary amyloidosis and renal transplant, who was resistant to colchicine treatment.
Alpay
Nilüfer
N
Department of Internal Medicine, Istanbul School of Medicine, Istanbul University, Capa, Istanbul, Turkey. nalpay@istanbul.edu.tr
Sumnu
Abdullah
A
Calışkan
Yaşar
Y
Yazıcı
Halil
H
Türkmen
Aydın
A
Gül
Ahmet
A
D000686:Amyloidosis / Q000209:etiology / Q000628:therapy; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003078:Colchicine / Q000627:therapeutic use*; D004351:Drug Resistance; D010505:Familial Mediterranean Fever / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation; D008875:Middle Aged; D017211:Treatment Failure
D000893:Anti-Inflammatory Agents; D053590:Interleukin 1 Receptor Antagonist Protein; D003078:Colchicine
Ann Rheum Dis. 2007 Nov;66(11):1545-6
17934085
Semin Arthritis Rheum. 2004 Feb;33(4):273-82
14978665
Nephron. 1992;60(4):418-22
1584316
Clin Exp Rheumatol. 2004 Jul-Aug;22(4 Suppl 34):S37-40
15515782
Eur J Pediatr. 2008 Jun;167(6):695-6
17588171
Nephrol Dial Transplant. 2009 Feb;24(2):676-8
19033248
J Clin Rheumatol. 2007 Feb;13(1):38-40
17278949
Eur J Hum Genet. 2001 Jul;9(7):473-83
11464238
Arthritis Rheum. 2002 Mar;46(3):614-24
11920396
Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9982-7
16785446