title: Synthesis and antitumor activity of new shikonin glycosides.
abstract: Eleven shikonin glycosides were synthesized and evaluated for their antitumor activity in vitro. Some of them were found to exhibit cytotoxic activities against both drug sensitive cell lines (K562, MCF-7 and HL60) and their drug resistant cell sublines (K562/ADR, MCF-7/ADR and HL60/ADR).
authors.affiliation: Department of Chemistry, Zhejiang University, 38# Zheda Road, Hangzhou 310027, PR China.
authors.forename: Yehua
authors.initials: Y
authors.lastname: Su
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Xie
authors.forename: Yanguang
authors.initials: Y
authors.lastname: Wang
authors.forename: Xun
authors.initials: X
authors.lastname: Hu
authors.forename: Xianfu
authors.initials: X
authors.lastname: Lin
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D009285:Naphthoquinones / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D006027:Glycosides; D009285:Naphthoquinones; C016101:shikonin