Association between mammalian lifespan and circadian free-running period: the circadian resonance hypothesis revisited.
Biological rhythms that oscillate with periods close to 24 h (circadian cycles) are pervasive features of mammalian physiology, facilitating entrainment to the 24 h cycle generated by the rotation of the Earth. In the absence of environmental time cues, circadian rhythms default to their endogenous period called tau, or the free-running period. This sustained circadian rhythmicity in constant conditions has been reported across the animal kingdom, a ubiquity that could imply that innate rhythmicity confers an adaptive advantage. In this study, we found that the deviation of tau from 24 h was inversely related to the lifespan in laboratory mouse strains, and in other rodent and primate species. These findings support the hypothesis that misalignment of endogenous rhythms and 24 h environmental cycles may be associated with a physiological cost that has an effect on longevity.
Wyse
C A
CA
Institute of Biological and Environmental Sciences, University of Aberdeen, Tillydrone Avenue, Aberdeen, AB24 2TZ, UK. c.wyse@abdn.ac.uk
Coogan
A N
AN
Selman
C
C
Hazlerigg
D G
DG
Speakman
J R
JR
D000818:Animals; D002940:Circadian Rhythm; D008017:Life Expectancy; D008322:Mammals / Q000502:physiology*; D010802:Phylogeny
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