title: Synthesis of 3-alkyl pyridinium alkaloids from the arctic sponge Haliclona viscosa.
abstract: 3-Alkyl pyridinium alkaloids (3-APAs) are common secondary metabolites in marine sponges of the order Haplosclerida. In recent years, our laboratory has isolated and synthesized several new members of this family such as haliclamines C-F, viscosamine, viscosaline and a cyclic monomer. All of them were isolated from the Arctic sponge Haliclona viscosa collected in Spitsbergen, Norway. In this article we report the syntheses of these secondary metabolites from Haliclona viscosa and related compounds and give a short overview of the bioactivity.
authors.affiliation: Alfred-Wegener-Institut für Polar- und Meeresforschung in der Helmholtz-Gemeinschaft, Am Handelshafen 12, D-27570 Bremerhaven, Germany.
authors.forename: Christoph
authors.initials: C
authors.lastname: Timm
authors.forename: Thorsten
authors.initials: T
authors.lastname: Mordhorst
authors.forename: Matthias
authors.initials: M
authors.lastname: Köck
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001688:Biological Products; D047129:Haliclona / Q000737:chemistry*; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D001688:Biological Products; D011726:Pyridinium Compounds
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