title: Simple quantitative analysis of asbestos body using the sediment of formalin injected into surgically resected lung cancers.
abstract: A simple screening method for quantitatively analyzing asbestos bodies that can be carried out even in community hospitals, is needed in order for laborers and neighborhoods in the vicinity of asbestos factories to apply for compensation for asbestos-related injury. Eighty-eight consecutive cases of surgically resected primary lung cancer were analyzed for asbestos bodies using two methods, and the correlation between them was statistically examined. The first was the conventional technique using lung tissue digestion and phase-contrast scanning, and the second was the authors' method using light microscopy to scan the sediment of formalin-injected lung specimens. The overall correlation coefficient of the concentration of asbestos bodies between the authors' method (C(AB/SED)) and the conventional method (C(AB/DLT)) was 0.4576, a weak statistically significant correlation; in patients with occupational asbestos exposure, however, the correlation coefficient was 0.7341. Despite the cost, it may be prudent to use the conventional method under the present law for patients with C(AB/SED)>or=3.5/mL. C(AB/DLT) >3000/g dry lung tissue when C(AB/SED) is >or=3.5/mL suggests the potential for the accumulation of asbestos absorption by lung tissue.
authors.affiliation: Department of Pathology, Hyogo Cancer Center, Hyogo, Japan.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Sakai
authors.forename: Chiho
authors.initials: C
authors.lastname: Ohbayashi
authors.forename: Hiroe
authors.initials: H
authors.lastname: Itami
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Kajimoto
authors.forename: Toshiko
authors.initials: T
authors.lastname: Sakuma
authors.forename: Kazuya
authors.initials: K
authors.lastname: Uchino
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshimura
authors.forename: Shoji
authors.initials: S
authors.lastname: Matsumoto
authors.forename: Yuka
authors.initials: Y
authors.lastname: Idei
authors.forename: Teruaki
authors.initials: T
authors.lastname: Oka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001194:Asbestos / Q000032:analysis*; D019411:Clinical Laboratory Techniques; D005260:Female; D005557:Formaldehyde; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016273:Occupational Exposure / Q000009:adverse effects
chemical_list: D001194:Asbestos; D005557:Formaldehyde