title: Mutative expression in Candida albicans infection and cytokine signaling network in gene knockout mice.
abstract: The interactions of Candida species with host cells are crucial for candidiasis. Recognition and adherence to host constituents are the keys to initial colonization of mucosal surfaces and the invasion of host cells. Resistance to mucosal candidiasis is mediated by cell-mediated immunity. Knowledge about host receptors on immune cells and the adhesins on the surface of C. albicans are more redundant, respectively, than about the ligands on the fungal surface and the structures on the host cells bound by adhesions. Silencing or disrupting specific genes both in the pathogen and the host are developing optimistically. The research on IL-12/23 p40 knockout (KO) mice is sound in providing preliminary array data about the principal pathways in oral C. albicans infection and clues about the molecular differences between wild-type (WT) and p40 KO mice of candidiasis in different sites, thus, hints that certain specific drug targets accessible to topical agents for the clinical treatment of oral candidiasis and relevant mucocutaneous precancerous lesions.
authors.affiliation: Department of Stomatology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
authors.forename: H
authors.initials: H
authors.lastname: He
authors.forename: Y
authors.initials: Y
authors.lastname: Cong
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Dong
mesh_terms: D000818:Animals; D002176:Candida albicans / Q000276:immunology* / Q000472:pathogenicity*; D002177:Candidiasis / Q000276:immunology* / Q000382:microbiology*; D020869:Gene Expression Profiling; D054884:Host-Pathogen Interactions; D053762:Interleukin-12 Subunit p40 / Q000172:deficiency*; D051379:Mice; D018345:Mice, Knockout; D015398:Signal Transduction
chemical_list: D053762:Interleukin-12 Subunit p40
references.citation: J Infect Dis. 2004 Oct 1;190(7):1327-34
references.pmid: 15346345
references.citation: Curr Opin Microbiol. 2006 Aug;9(4):333-9
references.pmid: 16837237
references.citation: Immunol Cell Biol. 2004 Apr;82(2):196-204
references.pmid: 15061774
references.citation: J Dent Res. 2005 Nov;84(11):966-77
references.pmid: 16246925
references.citation: Microbiology (Reading). 2008 Nov;154(Pt 11):3266-3280
references.pmid: 18957581
references.citation: Front Biosci. 2008 May 01;13:3334-51
references.pmid: 18508436
references.citation: Oral Microbiol Immunol. 2006 Aug;21(4):252-5
references.pmid: 16842510
references.citation: Immunology. 2006 Apr;117(4):433-42
references.pmid: 16556256
references.citation: Cell Microbiol. 2005 Apr;7(4):499-510
references.pmid: 15760450
references.citation: Microbiology (Reading). 2005 Sep;151(Pt 9):2923-2931
references.pmid: 16151204
references.citation: J Dent Res. 2005 May;84(5):445-50
references.pmid: 15840781
references.citation: Nat Rev Immunol. 2003 Sep;3(9):710-20
references.pmid: 12949495
references.citation: J Infect Dis. 1991 Nov;164(5):936-43
references.pmid: 1940472
references.citation: Front Biosci. 2008 May 01;13:5345-58
references.pmid: 18508591