title: Lack of association of PON polymorphisms with sporadic ALS in an Italian population.
abstract: Paraoxonase (PON) gene polymorphisms have been associated with susceptibility to sporadic amyotrophic lateral sclerosis (ALS). We have investigated the role of the previously associated single nucleotide polymorphisms rs854560, rs662, and rs6954345 in 350 ALS patients and 376 matched controls from Italy. No significant association was observed at genotype and haplotype level. Our data suggest that PON polymorphisms are not involved in ALS pathogenesis in an Italian population.
authors.affiliation: Department of Neuroscience-Neurology Section, University of Siena, Siena, Italy.
authors.forename: Claudia
authors.initials: C
authors.lastname: Ricci
authors.forename: Stefania
authors.initials: S
authors.lastname: Battistini
authors.forename: Lorena
authors.initials: L
authors.lastname: Cozzi
authors.forename: Michele
authors.initials: M
authors.lastname: Benigni
authors.forename: Paola
authors.initials: P
authors.lastname: Origone
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Verriello
authors.forename: Christian
authors.initials: C
authors.lastname: Lunetta
authors.forename: Cristina
authors.initials: C
authors.lastname: Cereda
authors.forename: Pamela
authors.initials: P
authors.lastname: Milani
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Greco
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Patrosso
authors.forename: Renzo
authors.initials: R
authors.lastname: Causarano
authors.forename: Claudia
authors.initials: C
authors.lastname: Caponnetto
authors.forename: Fabio
authors.initials: F
authors.lastname: Giannini
authors.forename: Massimo
authors.initials: M
authors.lastname: Corbo
authors.forename: Silvana
authors.initials: S
authors.lastname: Penco
mesh_terms: D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D043303:Aryldialkylphosphatase / Q000235:genetics*; D016009:Chi-Square Distribution; D004252:DNA Mutational Analysis; D005260:Female; D005838:Genotype; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human