title: Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglycerides.
abstract: The objectives of this review were to determine whether the long-chain omega-3 fatty acids eicosapentaenoic acid and/or docosahexaenoic acid dose-dependently reduce fasting serum triglycerides (TG) and, if so, to create a mathematical model that may be used to predict potential percent reductions in fasting serum TG levels at the recommended intakes of 200-500 mg/day. The assessment included 15 randomized controlled trials that met pre-defined inclusion and exclusion criteria. Across these 15 studies, the dose-response was modeled using a first-order elimination curve. The response variable was defined as percent change from baseline in fasting serum TG, adjusted for the placebo effect. A weighting factor equal to the product of each study's sample size and quality score was used. Using the equation of the dose-response curve, predicted reductions in fasting serum TG levels at the recommended long-chain omega-3 fatty acid intakes of 200-500 mg/day are 3.1 to 7.2%.
authors.affiliation: Cantox Health Sciences International, Mississauga, Ontario, Canada. kmusa-veloso@cantox.com
authors.forename: Kathy
authors.initials: K
authors.lastname: Musa-Veloso
authors.forename: Malcolm Angus
authors.initials: MA
authors.lastname: Binns
authors.forename: Alexandra Catherine
authors.initials: AC
authors.lastname: Kocenas
authors.forename: Theresa
authors.initials: T
authors.lastname: Poon
authors.forename: Julie Ann
authors.initials: JA
authors.lastname: Elliot
authors.forename: Harry
authors.initials: H
authors.lastname: Rice
authors.forename: Hilde
authors.initials: H
authors.lastname: Oppedal-Olsen
authors.forename: Hilary
authors.initials: H
authors.lastname: Lloyd
authors.forename: Shawna
authors.initials: S
authors.lastname: Lemke
mesh_terms: D004281:Docosahexaenoic Acids / Q000008:administration & dosage* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage* / Q000378:metabolism; D005215:Fasting / Q000097:blood; D006801:Humans; D018673:Nutrition Policy; D016032:Randomized Controlled Trials as Topic; D014280:Triglycerides / Q000097:blood*
chemical_list: D014280:Triglycerides; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid