title: An unusual cause of multiple cerebral hemorrhages: drotrecogin alpha (activated protein C).
abstract: The mortality of severe sepsis is still high, despite improved treatment modalities. It is known that treatment with DAA reduces mortality in this condition; however, major bleeding may occur as a complication. We present a patient with normal findings on platelet and coagulation tests who developed multiple cerebral hemorrhages after DAA infusion. Patients with septic shock who undergo DAA infusion should be followed closely for possible intracranial bleeding. When intracranial hemorrhage is detected in patients in the intensive care unit, treatment with DAA infusion should be questioned.
authors.affiliation: Department of Radiology, Atatürk Training and Research Hospital, Ankara, Turkey. droktayalgin@gmail.com
authors.forename: O
authors.initials: O
authors.lastname: Algin
authors.forename: G
authors.initials: G
authors.lastname: Ceylan
authors.forename: E
authors.initials: E
authors.lastname: Kilic
mesh_terms: D002543:Cerebral Hemorrhage / Q000139:chemically induced* / Q000517:prevention & control; D005343:Fibrinolytic Agents / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011486:Protein C / Q000009:adverse effects* / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D012772:Shock, Septic / Q000150:complications* / Q000188:drug therapy*; D055815:Young Adult
chemical_list: D005343:Fibrinolytic Agents; D011486:Protein C; D011994:Recombinant Proteins; C421124:drotrecogin alfa activated
references.citation: Stroke. 2009 May;40(5):1864-9
references.pmid: 19057019
references.citation: Crit Care. 2007;11 Suppl 5:S6
references.pmid: 18269693
references.citation: Crit Care. 2008;12(2):120
references.pmid: 18394177
references.citation: Anaesthesia. 2003 Sep;58(9):913-4
references.pmid: 12911371
references.citation: N Engl J Med. 2005 Sep 29;353(13):1332-41
references.pmid: 16192478
references.citation: N Engl J Med. 2009 Dec 31;361(27):2646-52
references.pmid: 20042756
references.citation: Crit Care. 2007;11 Suppl 5:S5
references.pmid: 18269692