title: Correlation between [18f]fluorodeoxyglucose positron-emission tomography scan and histology of pelvic nodes in early-stage cervical cancer.
abstract: BACKGROUND
  The histological results of pelvic lymphadenectomy were studied in patients treated for early-stage cervical cancer (<4 cm) who had no nodal uptake on [(18)F]fluorodeoxyglucose positron-emission tomography combined with integrated computed tomography (FDG-PET/CT).
  
  
  METHODS
  Patients treated between 2005 and 2008 for stage IB1 cervical cancer cancer <4 cm who underwent a FDG-PET/CT followed by surgical evaluation of pelvic nodes were reviewed.
  
  
  RESULTS
  A total of 16 patients were studied. The median age of patients was 43 (range 29-62) years. Surgery was performed laparoscopically and by laparotomic approach in 13 and 3 cases, respectively. Two patients had histologically proven pelvic involvement. The false-negative rate and negative predictive value of PET-CT imaging for pelvic nodal involvement were 13% and 87%, respectively.
  
  
  CONCLUSIONS
  The accuracy of PET-CT imaging in predicting the pelvic nodal status is very low in patients with early-stage cervical cancer and is not able to replace lymphadenectomy.
authors.affiliation: Department of surgery, Gustave Roussy Institute University Paris Sud, 39 rue Camille Desmoulins, 94805 Villejuif Cedex, France.
authors.forename: Enrica
authors.initials: E
authors.lastname: Bentivegna
authors.forename: Catherine
authors.initials: C
authors.lastname: Uzan
authors.forename: Sebastien
authors.initials: S
authors.lastname: Gouy
authors.forename: Sophie
authors.initials: S
authors.lastname: Leboulleux
authors.forename: Pierre
authors.initials: P
authors.lastname: Duvillard
authors.forename: Jean
authors.initials: J
authors.lastname: Lumbroso
authors.forename: Christine
authors.initials: C
authors.lastname: Haie-Meder
authors.forename: Martin
authors.initials: M
authors.lastname: Schlumberger
authors.forename: Philippe
authors.initials: P
authors.lastname: Morice
mesh_terms: D000328:Adult; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000493:pharmacokinetics; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D049268:Positron-Emission Tomography / Q000379:methods; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology / Q000601:surgery
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18