Marker-free lung tumor trajectory estimation from a cone beam CT sinogram.
An algorithm was developed to estimate the 3D lung tumor position using the projection data forming a cone beam CT sinogram and a template registration method. A pre-existing respiration-correlated CT image was used to generate templates of the target, which were then registered to the individual cone beam CT projections, and estimates of the target position were made for each projection. The registration search region was constrained based on knowledge of the mean tumor position during the cone beam CT scan acquisition. Several template registration algorithms were compared, including correlation coefficient and robust methods such as block correlation, robust correlation coefficient and robust gradient correlation. Robust registration metrics were found to be less sensitive to occlusions such as overlying tissue and the treatment couch. The mean accuracy of the position estimation was 1.4 mm in phantom with a robust registration algorithm. In two research subjects with peripheral tumors, the mean position and mean target excursion were estimated to within 2.0 mm compared to the results obtained with a '4D' registration of 4D image volumes.
Hugo
Geoffrey D
GD
Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA, USA. gdhugo@vcu.edu
Liang
Jian
J
Yan
Di
D
D054893:Cone-Beam Computed Tomography / Q000379:methods* / Q000592:standards; D006801:Humans; D021621:Imaging, Three-Dimensional; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D012015:Reference Standards
Int J Radiat Oncol Biol Phys. 1999 Jul 1;44(4):911-9
10386650
Phys Med Biol. 2008 Aug 21;53(16):N315-27
18660557
Phys Med Biol. 2009 Jan 7;54(1):117-33
19075358
Phys Med Biol. 2008 Aug 21;53(16):4331-53
18660559
Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1634-41
18029112
Phys Med Biol. 2008 Feb 21;53(4):1087-98
18263960
Med Phys. 2005 Apr;32(4):1176-86
15895601
Phys Med Biol. 2005 Oct 7;50(19):4481-90
16177484
Lung Cancer. 2006 Jan;51(1):41-51
16198022
Int J Radiat Oncol Biol Phys. 2000 Jul 1;47(4):1121-35
10863086
Phys Med Biol. 2007 Oct 21;52(20):6229-42
17921582
IEEE Trans Med Imaging. 2004 Nov;23(11):1430-44
15554130
Int J Radiat Oncol Biol Phys. 2008 Nov 15;72(4):1221-7
18954716
Med Phys. 2009 Jul;36(7):3059-71
19673205
Med Phys. 2006 Oct;33(10):3874-900
17089851
Int J Radiat Oncol Biol Phys. 2000 Nov 1;48(4):1187-95
11072178
Med Phys. 2004 Oct;31(10):2738-41
15543778
Int J Radiat Oncol Biol Phys. 2008 Feb 1;70(2):590-8
18037579
Int J Radiat Oncol Biol Phys. 2007 Jul 15;68(4):1036-46
17379442
Int J Radiat Oncol Biol Phys. 2008 Dec 1;72(5):1587-96
19028282
Phys Med Biol. 2006 May 21;51(10):2567-83
16675870
Phys Med Biol. 2005 Jun 21;50(12):2779-98
15930602
Int J Radiat Oncol Biol Phys. 2008 Nov 15;72(4):1250-8
18823717
Med Phys. 2008 May;35(5):1718-33
18561647
IEEE Trans Image Process. 2005 Aug;14(8):1063-73
16121455
Radiother Oncol. 2007 Apr;83(1):57-64
17306394
Med Phys. 2008 May;35(5):1793-806
18561654
Int J Radiat Oncol Biol Phys. 1999 Oct 1;45(3):603-11
10524412