Evaluation of antiulcer and antisecretory potential of Linum usitatissimum fixed oil and possible mechanism of action.
The aim of the study was to evaluate the antiulcer activity of Linum usitatissimum fixed oil against aspirin-, indomethacin-, ethanol-, reserpine-, serotonin- and stress-induced gastric ulceration in rats and histamine-induced gastric ulceration in guinea pigs. Attempts were also made to evaluate the in vitro anticholinergic and antihistaminic activity and in vivo antisecretary and antiulcer activity of oil following pylorus ligation in rats. L. usitatissimum fixed oil exhibited significant antiulcer activity against different ulcerogens in experimental animal models. The fixed oil significantly inhibited acetylcholine- and histamine-induced contraction of guinea pig and rat ileums, respectively, suggesting its anticholinergic and antihistaminic activity. The oil also exhibited significant inhibitory effect on gastric secretion/total acidity and aspirin-induced gastric ulceration in pylorus-ligated rats. The lipoxygenase inhibitory, histamine antagonistic and antisecretory (anticholinergic) effects of the oil could probably have contributed towards antiulcer activity. L. usitatissimum fixed oil may be considered to be a drug of natural origin which possesses significant antiulcer activity. The present observation is the first experimental data showing antiulcer activity of L. usitatissimum fixed oil.
Kaithwas
Gaurav
G
Department of Pharmaceutical Sciences, Faculty of Health and Medical Sciences, Allahabad Agricultural Institute-Deemed University, Allahabad, Uttar Pradesh, India.
Majumdar
Dipak K
DK
D000109:Acetylcholine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000494:pharmacology; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology; D019597:Flax / Q000737:chemistry*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006168:Guinea Pigs; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007082:Ileum / Q000187:drug effects; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology; D008026:Ligation / Q000009:adverse effects; D008043:Linseed Oil / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D016595:Misoprostol / Q000008:administration & dosage / Q000627:therapeutic use; D009119:Muscle Contraction / Q000187:drug effects; D011398:Promethazine / Q000494:pharmacology; D011708:Pylorus / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar; D012110:Reserpine / Q000008:administration & dosage / Q000494:pharmacology; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D013315:Stress, Psychological / Q000150:complications
D018680:Cholinergic Antagonists; D006634:Histamine H1 Antagonists; D016595:Misoprostol; D012701:Serotonin; D000431:Ethanol; D001285:Atropine; D008043:Linseed Oil; D002927:Cimetidine; D006632:Histamine; D012110:Reserpine; D011398:Promethazine; D000109:Acetylcholine; D001241:Aspirin; D007213:Indomethacin
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