Malaria gametocytogenesis.
Male and female gametocytes are the components of the malaria parasite life cycle which are taken up from an infected host bloodstream by mosquitoes and thus mediate disease transmission. These gamete precursors are morphologically and functionally quite distinct from their asexual blood stage counterparts and this is reflected in their distinct patterns of gene expression, cellular development and metabolism. Recent transcriptome, proteome and reverse genetic studies have added valuable information to that obtained from traditional studies. However, we still have no answer to the fundamental question regarding sexual development: 'what triggers gametocytogenesis'? In the current climate of eradication/elimination, tackling transmission by killing gametocytes has an important place on the agenda because most antimalarial drugs, whilst killing asexual blood stage parasites, have no effect on the transmissible stages.
Baker
David A
DA
Department of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, UK. david.baker@lshtm.ac.uk <david.baker@lshtm.ac.uk>
D000818:Animals; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D005818:Genetic Engineering; D005827:Genetics, Microbial; D008018:Life Cycle Stages; D010963:Plasmodium falciparum / Q000235:genetics / Q000502:physiology*; D020543:Proteome
D020543:Proteome
J Biol Chem. 2009 May 22;284(21):14537-46
19304662
Blood. 1988 Dec;72(6):1922-5
3058230
Infect Immun. 2000 Jun;68(6):3455-62
10816498
Trends Parasitol. 2003 Oct;19(10):452-60
14519583
Trends Parasitol. 2005 Jun;21(6):262-4
15922244
Nature. 2006 Feb 23;439(7079):1004-8
16382237
J Protozool. 1989 Sep-Oct;36(5):451-4
2681714
Mol Biochem Parasitol. 1995 Nov;74(2):143-56
8719156
Mol Biochem Parasitol. 2004 Sep;137(1):35-41
15279949
Mol Biochem Parasitol. 1994 May;65(1):11-22
7935618
Int J Parasitol. 2008 Mar;38(3-4):327-40
17950739
Zhonghua Yi Xue Za Zhi. 1994 Apr;74(4):209-10, 253-4
7922759
PLoS One. 2007 Oct 10;2(10):e1023
17925871
Trans R Soc Trop Med Hyg. 1981;75(2):316-7
7029805
Parasitol Res. 1990;76(3):214-8
2179946
J Exp Med. 1961 Dec 1;114:1049-62
13911722
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13004-9
19625622
Parasitol Today. 1991 Aug;7(8):199-203
15463493
Nat Struct Biol. 2003 Mar;10(3):197-203
12577051
Mol Biochem Parasitol. 2005 Apr;140(2):153-60
15760655
Mol Cell Biol. 1993 Dec;13(12):7349-57
8246955
Antimicrob Agents Chemother. 2004 Oct;48(10):3940-3
15388456
Biochem Pharmacol. 1992 Apr 1;43(7):1545-53
1314606
Mol Biochem Parasitol. 1998 Jun 1;93(2):167-77
9662702
Mol Biochem Parasitol. 1993 Jun;59(2):263-75
8341324
Exp Parasitol. 1993 Aug;77(1):74-8
8344408
FEMS Microbiol Rev. 2006 Jul;30(4):596-630
16774588
Am J Hyg. 1956 Jul;64(1):1-11
13339773
Trans R Soc Trop Med Hyg. 1949 Mar;42(5):455-63
18118367
Am J Trop Med Hyg. 1999 Jan;60(1):7-13
9988315
Proc Biol Sci. 2009 Oct 22;276(1673):3721-6
19656795
Antimicrob Agents Chemother. 2009 Oct;53(10):4080-5
19651911
J Infect Dis. 2006 Apr 15;193(8):1151-9
16544256
Nature. 1980 Jul 31;286(5772):490-2
6250067
Am J Trop Med Hyg. 2007 Mar;76(3):470-4
17360869
Mol Biochem Parasitol. 1994 Jan;63(1):163-5
8183317
Curr Pharm Des. 2006;12(24):3015-24
16918430
Genome Res. 2004 Nov;14(11):2308-18
15520293
Science. 2005 Jan 7;307(5706):82-6
15637271
Mol Microbiol. 2008 Jan;67(2):278-90
18086189
Eur J Med Chem. 2009 Mar;44(3):937-53
18930565
Mol Biochem Parasitol. 1994 Dec;68(2):189-96
7739665
Trans R Soc Trop Med Hyg. 1996 Nov-Dec;90(6):621-4
9015496
Nature. 2002 Oct 3;419(6906):537-42
12368870
J Parasitol. 2004 Oct;90(5):1062-71
15562607
Parasite. 2000 Mar;7(1):19-26
10743643
Nature. 1989 Nov 23;342(6248):438-40
2586613
Trends Parasitol. 2008 Jan;24(1):9-10
18024199
Mol Biochem Parasitol. 2005 Sep;143(1):100-10
16026866
Trans R Soc Trop Med Hyg. 1996 May-Jun;90(3):309-12
8758088
Mol Microbiol. 2007 Oct;66(2):291-302
17784927
Int J Parasitol. 1997 Sep;27(9):975-87
9363480
Trends Parasitol. 2008 Oct;24(10):449-54
18760671
Mol Biochem Parasitol. 2005 Sep;143(1):67-79
16005087
Microbiol Rev. 1993 Dec;57(4):953-94
8302218
Eukaryot Cell. 2009 Jan;8(1):128-32
18996983
Parasitol Today. 2000 Mar;16(3):102-7
10689328
Science. 2004 Dec 10;306(5703):1934-7
15591203
J Protozool. 1982 Aug;29(3):454-8
6290655
Exp Parasitol. 1994 Aug;79(1):50-6
8050525
Nature. 2002 Oct 3;419(6906):498-511
12368864
J Parasitol. 1991 Jun;77(3):346-52
2040946
Parasitology. 1994 Feb;108 ( Pt 2):129-37
8159458
Trans R Soc Trop Med Hyg. 1971;65(5):549-59
5003557
Mol Microbiol. 2009 Jul;73(2):180-93
19570101
Parasitology. 2009 Oct;136(12):1427-34
19660156
J Biol Chem. 1997 Feb 14;272(7):3961-6
9020100
Mol Biochem Parasitol. 2000 Apr 30;108(1):67-78
10802319
Parasitology. 1948 Feb;38(4):264-70
18907589
J Protozool. 1992 May-Jun;39(3):429-32
1640389
Mol Microbiol. 2006 Aug;61(4):991-8
16879650
Bull World Health Organ. 1979;57 Suppl 1:37-52
397008
Antimicrob Agents Chemother. 2004 Apr;48(4):1329-34
15047537
Int J Parasitol. 1990 Aug;20(5):615-8
2228424
Z Parasitenkd. 1975 Jul 16;46(4):297-9
812282
Science. 2000 Jan 7;287(5450):128-31
10615046
Immunol Lett. 1990 Aug;25(1-3):77-81
1704351
Annu Rev Microbiol. 2009;63:249-67
19575561
Proc Biol Sci. 1997 Apr 22;264(1381):553-9
9149425
Am J Trop Med Hyg. 1998 Feb;58(2):176-82
9502601
Mol Biochem Parasitol. 1996 Oct 30;81(2):253-7
8898341
Parasitology. 1982 Feb;84(1):1-11
7038594
PLoS Clin Trials. 2006 Aug 18;1(4):e20
17013431
Exp Parasitol. 1982 Dec;54(3):391-6
6759150
Trans R Soc Trop Med Hyg. 1982;76(2):242-50
7048650
Science. 2003 Sep 19;301(5640):1734-6
14500986
Mol Biochem Parasitol. 2009 Aug;166(2):93-8
19450726
Parasitology. 1977 Feb;74(1):1-8
320542
Eukaryot Cell. 2006 Aug;5(8):1206-14
16896206
Trop Med Int Health. 1997 Mar;2(3):227-9
9491100
Nature. 2007 Mar 1;446(7131):88-91
17330044
Parasitology. 2000 Aug;121 ( Pt 2):127-33
11085232
Ann Trop Med Parasitol. 1985 Dec;79(6):607-16
3914863
Appl Parasitol. 1993 Sep;34(3):153-60
8220571
PLoS One. 2008 May 28;3(5):e2280
18509532
Exp Parasitol. 1989 Aug;69(2):140-9
2666152
Exp Parasitol. 1995 Sep;81(2):227-35
7556565
Genes Dev. 2008 Apr 15;22(8):1051-68
18367645
Cell. 2005 Jun 3;121(5):675-87
15935755
Mol Biochem Parasitol. 2009 Dec;168(2):172-6
19712704
Exp Parasitol. 2007 Aug;116(4):497-503
17367781
Parasitology. 1990 Apr;100 Pt 2:191-200
2189114
Lancet. 1996 Jun 15;347(9016):1654-8
8642959
Cell. 2009 Jan 9;136(1):136-48
19135895
Parasitology. 2000 Nov;121 Pt 5:465-71
11128797
J Parasitol. 1983 Jun;69(3):592-7
6313893
Infect Immun. 2004 Nov;72(11):6597-602
15501792
Science. 2006 Aug 4;313(5787):667-9
16888139
Curr Genet. 1993;23(4):360-4
8467535
PLoS Med. 2005 Apr;2(4):e92
15839740
Cell. 2001 Jan 12;104(1):153-64
11163248
Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):8292-6
8367496
Mol Biochem Parasitol. 2005 Sep;143(1):90-9
15996767
Nat Protoc. 2006;1(1):346-56
17406255
Science. 2004 Dec 10;306(5703):1930-3
15591202
Nature. 2008 May 29;453(7195):609-14
18509435
Trends Parasitol. 2002 Nov;18(11):483-6
12473363
PLoS Pathog. 2010 Jan 22;6(1):e1000737
20107518
Proc R Soc Lond B Biol Sci. 1978 Jun 5;201(1145):375-99
27809
Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5414-9
15797990
Mol Cell Biol. 1999 Feb;19(2):967-78
9891033
Science. 1976 Aug 20;193(4254):673-5
781840
Mol Biochem Parasitol. 1986 Aug;20(2):173-82
3092048
Mol Biochem Parasitol. 1985 Feb;14(2):127-39
4039406
Exp Parasitol. 1989 Apr;68(3):274-82
2649389