Is seroquel developing an illicit reputation for misuse/abuse?
Quetiapine, an atypical antipsychotic, has been the subject of a series of case reports that suggest a potential for misuse/abuse. The available cases indicate a male predominance; oral, intranasal, or intravenous routes of administration; misuse/abuse in jail or inpatient psychiatric settings; and subjects with extensive histories of polysubstance abuse. While possible pharmacological explanations have been proffered, compared to the other atypical antipsychotics, there is no clear explanation for an alleged higher risk of misuse/abuse with quetiapine. Likewise, there are no available animal or human empirical studies to evaluate risk. At this juncture, clinicians in psychiatric and primary care settings can only remain alert to a potential risk, particularly in patients who meet the current demographic profile.
Sansone
Randy A
RA
Dr. R. Sansone is a professor in the Departments of Psychiatry and Internal Medicine at Wright State University School of Medicine in Dayton, Ohio, and Director of Psychiatry Education at Kettering Medical Center in Kettering, Ohio.
Sansone
Lori A
LA
Am J Health Syst Pharm. 2007 Apr 1;64(7):723-5
17384357
Hum Psychopharmacol. 2008 Jul;23(5):417-24
18425995
J Clin Psychiatry. 2005 Oct;66(10):1285-8
16259542
Expert Opin Drug Saf. 2008 Nov;7(6):739-48
18983220
Prim Care Companion J Clin Psychiatry. 2004;6(Suppl 2):3-7
16001094
Am J Psychiatry. 2005 Sep;162(9):1755-6
16135642
J Clin Psychopharmacol. 2008 Apr;28(2):221-4
18344735
J Clin Psychiatry. 2008 Jan;69(1):162-3
18312052
Am J Psychiatry. 2007 Jan;164(1):173-4
17202567
J Psychiatr Pract. 2006 Nov;12(6):348-63
17122696
South Med J. 2007 Aug;100(8):834-6
17713313
CNS Drugs. 2006;20(5):389-409
16696579
Am J Psychiatry. 2007 Feb;164(2):350
17267808
Am J Psychiatry. 2004 Sep;161(9):1718
15337673
J Clin Psychopharmacol. 2004 Oct;24(5):532-5
15349010
Am J Health Syst Pharm. 2008 Apr 1;65(7):611-8
18359967
Am J Psychiatry. 2008 Jul;165(7):918
18593794
CMAJ. 2005 Jun 21;172(13):1703-11
15967975
J Psychiatry Neurosci. 2004 Nov;29(6):452-7
15644986
Can J Psychiatry. 2004 Oct;49(10):711
15560324
Am J Psychiatry. 2007 Jan;164(1):174-5
17202569
J Psychopharmacol. 2007 Jun;21(4):392-9
17656426
Perspect Psychiatr Care. 2008 Jul;44(3):202-6
18577126
Am J Addict. 2008 Sep-Oct;17(5):454-5
18770092
S D Med. 2007 Nov;60(11):437, 439-41, 443 passim
18196687