Effects of periarticular steroid injection on knee function and the inflammatory response following Unicondylar Knee Arthroplasty.
There is little information on the values of CRP and ESR as markers for inflammation in Unicondylar Knee Arthroplasty. The effect of periarticular steroid injection in post-operative pain relief and clinical recovery has not been well studied. Eighty-three consecutive patients undergoing primary UKAs were randomized to receive either an intra-operative periarticular injection with a local anaesthetic and adrenaline or with the addition of triamcinolone acetonide. CRP and ESR values, pain VAS and other scores, as well as clinical functional parameters, were obtained and analysed. Patients were assessed daily till discharge and up to 6 months post-operatively. Plasma CRP and ESR fluctuate after a UKA, with normalizing values indicating uneventful recovery. Periarticular steroid injections reduce post-operative pain and inflammation, and are clinically relevant as they improve short-term functional recovery and clinical parameters, resulting in better outcomes for patients without having major complications.
Ng
Yung Chuan Sean
YC
Department of Orthopaedic Surgery, Block 6 Level 7, Singapore General Hospital, Outram Road, Singapore 169608, Singapore. seanng31@gmail.com
Lo
Ngai Nung
NN
Yang
Kuang Ying
KY
Chia
Shi Lu
SL
Chong
Hwei Chi
HC
Yeo
Seng Jin
SJ
D000368:Aged; D019645:Arthroplasty, Replacement, Knee; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D010147:Pain Measurement; D011184:Postoperative Period; D016059:Range of Motion, Articular; D020127:Recovery of Function; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
D002097:C-Reactive Protein; D014222:Triamcinolone Acetonide
Surg Technol Int. 2003;11:282-6
12931312
Anaesthesia. 2007 Sep;62(9):888-94
17697214
J Bone Joint Surg Am. 2008 Jan;90(1):2-9
18171951
Ann Readapt Med Phys. 2008 Jun;51(5):348-57
18547673
J Int Med Res. 2001 Jan-Feb;29(1):7-12
11277348
Instr Course Lect. 2004;53:265-83
15116621
Knee Surg Sports Traumatol Arthrosc. 2007 Aug;15(8):1028-34
17497127
J Knee Surg. 2002 Winter;15(1):17-22
11829329
Singapore Med J. 2003 Nov;44(11):559-62
15007494
Thromb Haemost. 1982 Aug 24;48(1):6-8
7135344
Arch Gerontol Geriatr. 2005 Sep-Oct;41(2):169-76
16085068
Ann Rheum Dis. 2001 Mar;60(3):275-7
11171691
Knee Surg Sports Traumatol Arthrosc. 2005 Apr;13(3):179-86
15175850
Anesth Analg. 2008 Apr;106(4):1253-7, table of contents
18349202
Acta Orthop. 2008 Aug;79(4):499-507
18766483
J Int Med Res. 2006 Nov-Dec;34(6):603-11
17294992
Int Orthop. 2007 Jun;31(3):315-9
16896871
Clin Orthop Relat Res. 2001 Nov;(392):226-31
11716387
Clin Orthop Relat Res. 1995 Aug;(317):185-7
7671475
J Arthroplasty. 2002 Jan;17(1):108-10
11805935
Orthopedics. 2003 Aug;26(8 Suppl):s859-63
12934741
J Bone Joint Surg Br. 2008 Jun;90(6):738-44
18539666
Clin Orthop Relat Res. 2006 Oct;451:101-6
16760806
Am J Orthop (Belle Mead NJ). 2007 Sep;36(9 Suppl):6-7
17948160
J Arthroplasty. 2003 Oct;18(7 Suppl 1):2-8
14560403
Ann Rheum Dis. 1997 Nov;56(11):634-6
9462163
J Bone Joint Surg Am. 2006 May;88(5):959-63
16651569
J Bone Joint Surg Br. 1998 Sep;80(5):909-11
9768908
J Knee Surg. 2006 Apr;19(2):112-6
16642887
Clin Orthop Relat Res. 2004 Nov;(428):125-30
15534532
Arthritis Rheum. 2000 Sep;43(9):1905-15
11014340
Clin Orthop Relat Res. 1984 Apr;(184):118-20
6705332