title: Dynamic contrast-enhanced magnetic resonance imaging of canine brain tumors.
abstract: We evaluated dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in canine brain tumors. Magnetic resonance data sets were collected on seven canine intracranial tumors with a 3 T magnet using a T1-weighted fast spin echo fluid attenuated inversion recovery sequence after an IV bolus injection (0.2 mmol/kg) of Gd-DTPA. The tumors were confirmed histopathologically as adenocarcinoma (n=1), ependymoma (n=1), meningioma (n=3), oligodendroglioma (n=1), and pituitary macroadenoma (n=1) The data were analyzed using a two-compartment pharmacokinetic model for estimation of three enhancement parameters, E(R) (rate of enhancement), Kel (rate of elimination), and Kep (rate constant), and a model-free phenomenologic parameter initial area under the Gd concentration curve (IAUGC) defined over the first 90s postenhancement. Pearson's correlations were calculated between parameters of the two methods. The IAUGC has a relatively strong association with the rate of enhancement E(R), with r ranges from 0.4 to 0.9, but it was weakly associated with Kep and Kel. To determine whether any two tumors differed significantly, the Kohnlmogorov-Smirnov test was used. The results showed that there were statistical differences (P < 0.05) between distributions of the enhancement pattern of each tumor. These kinetic parameters may characterize the perfusion and vascular permeability of the tumors and the IAUGC may reflect blood flow, vascular permeability, and the fraction of interstitial space. The kinetic parameters and the IAUGC derived from DCE-MRI present complementary information and they may be appropriate to noninvasively differentiate canine brain tumors although a larger prospective study is necessary.
authors.affiliation: Department of Physics & Astronomy, Biolmaging Research Center, University of Georgia, Athens, GA, USA. qzhao@physast.uga.edu
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhao
authors.forename: Sunbok
authors.initials: S
authors.lastname: Lee
authors.forename: Marc
authors.initials: M
authors.lastname: Kent
authors.forename: Scott
authors.initials: S
authors.lastname: Schatzberg
authors.forename: Simon
authors.initials: S
authors.lastname: Platt
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000662:veterinary*; D003287:Contrast Media / Q000493:pharmacokinetics*; D004283:Dog Diseases / Q000175:diagnosis* / Q000378:metabolism; D004285:Dogs; D019786:Gadolinium DTPA / Q000493:pharmacokinetics*; D008279:Magnetic Resonance Imaging / Q000379:methods / Q000662:veterinary*
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA