title: Practical tip: Precooling topical calcineurin inhibitors tube; reduces burning sensation.
abstract: Burning sensation at the site of application is the most common side effect of topical calcineurin inhibitors and is considered the most common reasons for premature discontinuation. Here, we analyze the possible mechanism(s) and offer a simple practical tip to mitigate this adverse effect. Simple cooling of the tube, immediately before use, does reduce the burning sensation and enable most intolerant patients to use the medication comfortably. We also discuss the possible explanation(s) for the success of this maneuver.
authors.affiliation: College of Medicine, Division of Dermatology, Department of Medicine, King Abdulaziz Medical City, Riyadh, King Saud Bin Abdulaziz University for Health Sciences. salkhenaizan@hotmail.com
authors.forename: Sultan
authors.initials: S
authors.lastname: Al-Khenaizan
mesh_terms: D000287:Administration, Topical; D065095:Calcineurin Inhibitors; D003080:Cold Temperature; D003876:Dermatitis, Atopic / Q000188:drug therapy; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D016559:Tacrolimus / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*
chemical_list: D065095:Calcineurin Inhibitors; D003879:Dermatologic Agents; C117268:pimecrolimus; D016559:Tacrolimus