title: Morphometric characteristics of neuropeptide Y immunoreactive neurons in cortex of human inferior parietal lobule.
abstract: The aim of this study was to demonstrate and precisely define the morphology of neurons immunoreactive to neuropeptide Y (NPY) in cortex of human inferior parietal lobule (IPL). Five human brains were used for immunohistochemical investigation of the shape and laminar distribution of NPY neurons in serial section in the supramarginal and angular gyrus. Immunoreactivity to NPY was detected in all six layers of the cortex of human IPL. However a great number of NPY immunoreactive neurons were found in the white matter under the IPL cortex. The following types of NPY immunoreactive neurons were found: Cajal-Retzius, pyramidal, inverted pyramidal, "double bouquet" (bitufted), rare type 6, multipolar nonspinous, bipolar, voluminous "basket", and chandelier cells. These informations about morphometric characteristics of NPY immunoreactive neurons in cortical layers, together with morphometric data taken from brains having schizophrenia or Alzheimer's-type dementia may contribute to better understanding patogenesis of these neurological diseases. The finding of Cajal-Retzius neurons immunoreactive to NPY points to the need for further investigations because of great importance of these cells in neurogenesis and involvement in mentioned diseases instead of their rarity.
authors.affiliation: Department of Anatomy, School of Medicine, University of Novi Sad, Novi Sad, Serbia. drdragan.k@neobee.net
authors.forename: Dragan
authors.initials: D
authors.lastname: Krivokuća
authors.forename: Laslo
authors.initials: L
authors.lastname: Puskas
authors.forename: Nela
authors.initials: N
authors.lastname: Puskas
authors.forename: Mirela
authors.initials: M
authors.lastname: Erić
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000737:chemistry*; D009478:Neuropeptide Y / Q000032:analysis*; D010296:Parietal Lobe / Q000166:cytology*
chemical_list: D009478:Neuropeptide Y