Biological actions and interactions of anosmin-1.
Kallmann syndrome is a multigenic human developmental disorder where the molecular pathogenesis is still only partially understood and there is no single unifying animal model. The protein anosmin-1, encoded by the KAL1 gene, is associated with the X-linked form of the disease. The biology and molecular structure of anosmin-1 has been investigated systematically over the years by various cell culture experiments, biochemical analyses and animal models. Anosmin-1 is an extracellular matrix-associated protein which plays pleiotropic roles in neuronal development, migration and organogenesis.
Choy
Catherine
C
Kim
Soo-Hyun
SH
D000818:Animals; D004622:Embryo, Mammalian / Q000378:metabolism; D047108:Embryonic Development; D016326:Extracellular Matrix Proteins / Q000737:chemistry / Q000378:metabolism*; D050172:Genes, X-Linked; D006497:Heparan Sulfate / Q000378:metabolism; D006801:Humans; D017436:Kallmann Syndrome / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000378:metabolism*; D009474:Neurons / Q000502:physiology; D009830:Olfactory Bulb / Q000002:abnormalities*; D017434:Protein Structure, Tertiary / Q000502:physiology; D051496:Receptor, Fibroblast Growth Factor, Type 1 / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology
D016326:Extracellular Matrix Proteins; D006497:Heparan Sulfate; D009419:Nerve Tissue Proteins; D051496:Receptor, Fibroblast Growth Factor, Type 1; C076266:ANOS1 protein, human