Association between mannose-binding lectin gene polymorphisms and pre-eclampsia in Brazilian women.
OBJECTIVE
Mannose-binding lectin (MBL) is involved in the maintenance of an inflammatory environment in uterus. High MBL levels have been associated with successful pregnancies whereas low levels are involved in pre-eclampsia (PE) development. Here, we evaluated MBL2 gene polymorphisms in the structural and promoter regions addressing their association with PE.


METHODS
DNA samples from 162 control pregnant women and 157 pregnant PE women were genotyped and data compared with demographic and clinical characteristics.


RESULTS
High frequency of C and D alleles (related to low MBL levels) was observed in PE women when compared to controls (C: 0.08 versus 0.03, P = 0.006; D: 0.10 versus 0.05, P = 0.009). Grouping the MBL genotypes according to phenotype, a higher frequency of OO genotype was observed in PE women when compared to control women (0.15 versus 0.04, P = 0.007).


CONCLUSIONS
Our data suggest that women with genotypes associated with low MBL levels could be potential PE developers.
Vianna
Priscila
P
Department of Genetics, Federal University of Rio Grande do Sul, Porto Alegre, RS - Brazil
Da Silva
Gabriela Kniphoff
GK
Dos Santos
Bruno Paiva
BP
Bauer
Moisés Evandro
ME
Dalmáz
Caroline Abrão
CA
Bandinelli
Eliane
E
Chies
José Artur Bogo
JA
D000328:Adult; D001938:Brazil; D016009:Chi-Square Distribution; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D037601:Mannose-Binding Lectin / Q000235:genetics* / Q000276:immunology; D016297:Mutagenesis, Site-Directed; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics* / Q000276:immunology; D011247:Pregnancy; D011401:Promoter Regions, Genetic
D037601:Mannose-Binding Lectin; D004247:DNA