title: Deep brain stimulation for treatment refractory obsessive-compulsive disorder--a case report.
abstract: In the past 30 years it has been a great development in the unders-anding and therapy of obsessive-compulsive disorder. Adequate pharmaco- and cognitive-behavior therapies reduce the symptoms in 40-60% of patients, so a remarkable portion of patients still remains refractory to conventional treatment. Neurosurgery--with it's reversible and irreversible techniques--brought a breakthrough in the therapy of treatment refractory patients. In the present case, we represent a 3 months follow-up of an obsessive-compulsive pctient treated by deep brain stimulation. In our case, the stimulation target was the anterior limb of internal capsule. The clinical symptoms were measured by Y-BOCS. In addition various neuropsychological tests were used to monitor patient's executive functions before and 3 months after the deep brain stimulation. We found that obsessive-compu sive symptoms improved after three months of the stimulation. The neuropsychological tests showed improvement in some executive functions (e.g. fluency, set-shifting, decision making). On the other hand our results revealed severe neurocognitive--mainly attention skill--deficits in a treatment refractory obsessive-compulsive patient.
authors.affiliation: Department of Neurosurgery, St. John's Hospital, Budapest. csigokata@yahoo.com [corrected]
authors.forename: Katalin
authors.initials: K
authors.lastname: Csigó
authors.forename: Lászó
authors.initials: L
authors.lastname: Dome
authors.forename: I
authors.initials: I
authors.lastname: Valálik
authors.forename: András
authors.initials: A
authors.lastname: Harsányi
authors.forename: Gyula
authors.initials: G
authors.lastname: Demeter
authors.forename: Mihály
authors.initials: M
authors.lastname: Racsmány
mesh_terms: D000293:Adolescent; D000328:Adult; D046690:Deep Brain Stimulation; D004567:Electrodes, Implanted; D056344:Executive Function; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000523:psychology / Q000628:therapy*; D055815:Young Adult