title: Subepicardial adipose tissue thickness and its relation with anthropometric and clinical parameters in pubertal obese children.
abstract: OBJECTIVE
  To determine the relation of echocardiographic subepicardial adipose tissue (SAT) thickness with anthropometric and clinical parameters in pubertal obese children.
  
  
  METHODS
  A total of 52 obese pubertal subjects (13.1±1.56 yr, 27 male patients) and 39 age- and gender-matched lean pubertal subjects (13.0±1.28 yr, 16 male patients) were included in the study. Serum glucose, lipid profile, and insulin levels were measured during the fasting state. Each subject underwent a transthoracic echocardiography and the SAT thickness was measured during end-diastole from the parasternal long-axis views.
  
  
  RESULTS
  The obese pubertal subjects had significantly higher SAT, triceps skin fold (TSF) thickness (mm), waist (WC) and mid-arm circumference (MAC) values (cm) compared with lean pubertal subjects group (p<0.05). Correlation analysis showed that SAT thickness was significantly related with age, SD score-body mass index (SDS-BMI), BMI, WC, MAC, TSF, and homeostasis model assessment of insulin resistance (HOMA-IR) (p<0.05), whereas there was no significant relation of SAT with hip circumference and waist to hip ratio (p>0.05). As an optimal cut-off point, a SAT thickness of 5.25 mm determined IR with 92% sensitivity and 62.1% specificity.
  
  
  CONCLUSIONS
  Our study showed that SAT thickness in obese pubertal children shows a good correlation with age, SDS-BMI, BMI, WC, MAC, TSF, and HOMA-IR. In addition, our results suggest that SAT thickness might be used as a supportive data for risk stratification of metabolic syndrome in obese children.
authors.affiliation: Division of Pediatric Endocrinology, Kecioren Training and Research Hospital, Ankara, Turkey. ayhanabaci@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Abaci
authors.forename: O
authors.initials: O
authors.lastname: Ozdemir
authors.forename: S
authors.initials: S
authors.lastname: Hizli
authors.forename: C Hasan
authors.initials: CH
authors.lastname: Razi
authors.forename: N
authors.initials: N
authors.lastname: Kabakus
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D000293:Adolescent; D000886:Anthropometry; D015992:Body Mass Index; D016022:Case-Control Studies; D002648:Child; D004452:Echocardiography; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D009765:Obesity / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology; D009929:Organ Size; D010496:Pericardium; D011627:Puberty / Q000502:physiology; D013851:Thinness / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology
references.citation: J Clin Endocrinol Metab. 1995 Jan;80(1):172-8
references.pmid: 7829608
references.citation: Obes Rev. 2007 May;8(3):253-61
references.pmid: 17444966
references.citation: Horm Res. 2003;60(Suppl 1):36-45
references.pmid: 12955016
references.citation: Nat Clin Pract Cardiovasc Med. 2005 Oct;2(10):536-43
references.pmid: 16186852
references.citation: Int J Obes (Lond). 2007 Mar;31(3):550-8
references.pmid: 16953258
references.citation: J Endocrinol Invest. 2007 Jun;30(6):459-64
references.pmid: 17646719
references.citation: Histopathology. 2005 Jan;46(1):98-104
references.pmid: 15656892
references.citation: Am J Physiol Endocrinol Metab. 2000 May;278(5):E941-8
references.pmid: 10780952
references.citation: Pediatrics. 1992 Mar;89(3 Pt 2):525-84
references.pmid: 1538956
references.citation: J Pediatr. 1993 Dec;123(6):871-86
references.pmid: 8229519
references.citation: Int J Cardiol. 2008 Aug 29;128(3):424-6
references.pmid: 18375002
references.citation: J Clin Endocrinol Metab. 2008 Jun;93(6):2122-8
references.pmid: 18397988
references.citation: Int J Obes Relat Metab Disord. 2002 May;26(5):701-9
references.pmid: 12032756
references.citation: J Clin Endocrinol Metab. 2005 Nov;90(11):6300-2
references.pmid: 16091479
references.citation: Cytokine. 2008 Aug;43(2):174-80
references.pmid: 18562207
references.citation: J Clin Endocrinol Metab. 2007 Feb;92(2):517-22
references.pmid: 17105842
references.citation: Diabetes Care. 2002 Sep;25(9):1631-6
references.pmid: 12196439
references.citation: Diabetes Care. 1996 Dec;19(12):1404-11
references.pmid: 8941472
references.citation: Diabetes. 2008 May;57(5):1269-75
references.pmid: 18299316
references.citation: Nutr Metab Cardiovasc Dis. 2009 Mar;19(3):211-7
references.pmid: 18718744
references.citation: Pneumologie. 1989 Sep;43(9):490-9
references.pmid: 2813303
references.citation: J Pediatr. 2006 Feb;148(2):188-94
references.pmid: 16492427
references.citation: J Endocrinol Invest. 2001 Jun;24(6):438-44
references.pmid: 11434668
references.citation: Am J Clin Nutr. 1996 Jan;63(1):4-14
references.pmid: 8604668
references.citation: J Clin Endocrinol Metab. 2003 Nov;88(11):5163-8
references.pmid: 14602744
references.citation: Obesity (Silver Spring). 2008 Apr;16(4):887-92
references.pmid: 18379565
references.citation: Obes Res. 2003 Feb;11(2):304-10
references.pmid: 12582228
references.citation: Diabetes Care. 2003 Nov;26(11):3160-7
references.pmid: 14578255
references.citation: J Pediatr. 1987 Mar;110(3):481-7
references.pmid: 2950219
references.citation: Horm Res. 1997;48(5):219-26
references.pmid: 9362392
references.citation: Diabetes. 1999 Oct;48(10):2039-44
references.pmid: 10512371
references.citation: Circulation. 2003 Nov 18;108(20):2460-6
references.pmid: 14581396
references.citation: Int J Obes (Lond). 2009 Apr;33(4):440-6
references.pmid: 19223846
references.citation: Int J Cardiovasc Imaging. 2008 Aug;24(6):577-83
references.pmid: 18224456
references.citation: Nutr Metab Cardiovasc Dis. 2006 May;16(4):279-84
references.pmid: 16679220