Assessment of endothelial dysfunction.
The pathophysiology underlying the initiation and progression of cardiovascular disorders is highly complex and multifactorial. The endothelium also plays a crucial role in the pathogenesis of thrombogenesis and atherogenesis, and a continuum of endothelial activation, dysfunction or damage is evident in many cardiovascular disorders both at the macro and microscopic level(s). This review article aims to provide an overview of the assessment of endothelial (dys)function and discuss the implications and limitations of such assessments.
Freestone
Bethan
B
Hemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine Centre for Cardiovascular Sciences, City Hospital, Birmingham B187QH, UK.
Krishnamoorthy
Suresh
S
Lip
Gregory Y H
GY
D000818:Animals; D050197:Atherosclerosis / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans; D013927:Thrombosis / Q000503:physiopathology*