Defragmentation of low grade day 3 embryos resulted in sustained reduction in fragmentation, but did not improve compaction or blastulation rates.
In a prospective randomized fashion, this study evaluated embryo development in vitro after defragmentation versus assisted hatching alone of low grade day 3 embryos. Although a sustained decrease in day 5 fragmentation was observed in the defragmented group versus the assisted hatching only group, no difference in compaction rates or blastula formation rates were appreciated.
Keltz
Martin
M
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, St. Luke's Roosevelt Hospital Center, Columbia University College Of Physicians and Surgeons, New York, New York 10019, USA. mdkeltz@aol.com
Fritz
Rani
R
Gonzales
Eric
E
Ozensoy
Serhan
S
Skorupski
Josh
J
Stein
Daniel
D
D001755:Blastocyst / Q000166:cytology* / Q000378:metabolism; D036703:Blastula / Q000166:cytology* / Q000378:metabolism; D016022:Case-Control Studies; D002452:Cell Count; D002970:Cleavage Stage, Ovum / Q000166:cytology*; D042003:DNA Packaging / Q000235:genetics / Q000502:physiology*; D046149:Embryo Culture Techniques / Q000379:methods; D019924:Embryo Disposition; D047108:Embryonic Development / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011786:Quality Control; D011897:Random Allocation; D013997:Time Factors