Periodontitis case definition affects the association with renal function in kidney transplant recipients.
OBJECTIVE
The aim of this analysis was to investigate the association between periodontal status and renal allograft function in a cohort of renal transplant patients using different periodontitis case definitions.


METHODS
Fifty-eight kidney transplant patients were included. The subjects were classified into two groups, deterioration or stable/improvement of renal allograft function as expressed by the difference in glomerular filtration rate (GFR) between two time points at least 6 months apart. Chronic periodontitis was defined as: (1) two or more interproximal sites with clinical attachment level (CAL) ≥4 mm or two or more interproximal sites with probing depth (PD) ≥5 mm (DEF1); (2) PD ≥ 5 or CAL ≥ 4 in at least six proximal sites (DEF2); and (3) PD ≥ 5 or CAL ≥ 4 in at least two proximal sites in each quadrant (DEF3).


RESULTS
In a multivariate linear regression model, none of the continuous periodontal variables were significantly associated with deterioration of allograft function. Of the three definitions of chronic periodontitis, only DEF2 emerged as significantly more prevalent in subjects with GFR deterioration and was a statistically significant predictor of GFR deterioration over time.


CONCLUSIONS
These findings underscore the importance of periodontitis ‘case definition’ in the observed statistical associations between periodontitis and systemic disease.
Ioannidou
E
E
Division of Periodontology, Department of Oral Health and Diagnostic Sciences, School of Dental Medicine, University of Connecticut Health Center, Farmington, CT 06030-1710, USA.
Shaqman
M
M
Burleson
J
J
Dongari-Bagtzoglou
A
A
D002102:Cadaver; D055113:Chronic Periodontitis / Q000145:classification*; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000145:classification; D019214:Gingival Overgrowth / Q000145:classification; D005919:Glomerular Filtration Rate / Q000502:physiology; D006084:Graft Rejection / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000145:classification; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification; D014019:Tissue Donors; D014184:Transplantation, Homologous
D003404:Creatinine
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