title: Use of kilovoltage X-ray volume imaging in patient dose calculation for head-and-neck and partial brain radiation therapy.
abstract: BACKGROUND
  To evaluate the accuracy of using kilovoltage x-ray cone-beam computed tomography (kV-CBCT) imaging for in vivo dose calculations.
  
  
  METHODS
  A Region-of-Interest (ROI) CT number mapping method was developed to generate the cone-beam CT number vs. relative electron density calibration curve for 3D dose calculations. The stability of the results was validated for three consecutive months. The method was evaluated on three brain tumors and three head-and-neck tumor cases. For each patient, kV-CBCT images were acquired on the first treatment day and two-week intervals on the Elekta XVI system. The delivered dose distributions were calculated by applying the patients' treatment plans to the kV-CBCT images. The resulting dose distributions and dose volume histograms (DVHs) of the tumor and critical structures were compared to the original treatment plan.
  
  
  RESULTS
  The kV-CBCT electron density calibration was stable within 1.5% over a three-month period. The DVH and dose distribution comparison based on the planning CT and the initial kV-CBCT showed good agreements for majority of cases. The doses calculated from the planning CT and kV-CBCT were compared on planes perpendicular to the beam axes and passing through the isocenter. Using gamma analysis with a criterion of 2 mm/2% and a threshold of 10%, more than 99.5% of the points on the iso-planes exhibited gamma <1. For one patient, kV-CBCT images detected 5.8% dose variation in the right parotid due to tumor shrinkage and patient weight loss.
  
  
  CONCLUSIONS
  ROI mapping method is an effective method for the creation of kV-CBCT electron density calibration curves for head-and-neck and brain tumor patients. Dose variations as monitored using kV-CBCT imaging suggest that some patients can benefit from adaptive treatment plan re-optimization.
authors.affiliation: Department of Radiation Oncology, Cancer Hospital, Department of Oncology, Shanghai Medical college, Fudan University, Shanghai, China. zhenzhang6@yahoo.com
authors.forename: Weigang
authors.initials: W
authors.lastname: Hu
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ye
authors.forename: Jiazhou
authors.initials: J
authors.lastname: Wang
authors.forename: Xuejun
authors.initials: X
authors.lastname: Ma
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D005240:Feasibility Studies; D006258:Head and Neck Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000000981:diagnostic imaging / Q000532:radiotherapy; D009367:Neoplasm Staging; D011379:Prognosis; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014965:X-Rays
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