Immunization as treatment for Parkinson's disease.
Parkinson's disease and other neurodegenerative disorders share a common pathologic pathway with aggregation and deposition of misfolded proteins causing a disruption of particular neuronal networks. Several mechanisms have been implicated in the downstream events following deposition of misfolded proteins including free radical formation and failure of cellular defences such as autophagy or protein-degradation by the ubiquitin-proteasome pathway among many others. Treatments, however, capable of arresting or at least effectively modifying the course of disease do not yet exist. Recently, immunization approaches including passive and active immunization have been tested in animal models of various neurodegenerative disorders and have already entered into clinical trials for the treatment of Alzheimer's disease. In this review, we specifically focus on the current status of immune-based approaches that are presently developed as a potential therapy of Parkinson's disease.
Agbo
Daniela Besong
DB
Department of Neurology, Philipps-University Marburg, Marburg, Germany.
Neff
Frauke
F
Seitz
Florian
F
Binder
Christian
C
Oertel
Wolfgang H
WH
Bacher
Michael
M
Dodel
Richard
R
D000818:Animals; D006801:Humans; D007114:Immunization / Q000379:methods*; D010300:Parkinson Disease / Q000276:immunology* / Q000628:therapy*