Marine natural meroterpenes: synthesis and antiproliferative activity.
Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their biological activity on two bacterial strains, on sea urchin eggs, and on cancerous and healthy human cells.
Simon-Levert
Annabel
A
Laboratoire de Chimie des Biomolécules et de l'Environnement EA4215, Université de Perpignan, Perpignan Cedex, France. levert@univ-perp.fr
Menniti
Christophe
C
Soulère
Laurent
L
Genevière
Anne-Marie
AM
Barthomeuf
Chantal
C
Banaigs
Bernard
B
Witczak
Anne
A
D045784:Abietanes / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D006873:Hydroquinones / Q000138:chemical synthesis / Q000494:pharmacology*; D012617:Sea Urchins; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000138:chemical synthesis / Q000494:pharmacology*; D014561:Urochordata / Q000737:chemistry*
D045784:Abietanes; D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D006873:Hydroquinones; D013729:Terpenes; C547631:conicol; C550777:didehydroconicol; C505314:methoxyconidiol
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