title: Variations in locoregional therapy in postmenopausal patients with early breast cancer treated in different countries.
abstract: BACKGROUND
  The Tamoxifen and Exemestane Adjuvant Multinational (TEAM) trial is an international randomized trial evaluating the efficacy and safety of exemestane, alone or following tamoxifen. The large number of patients already recruited offered the opportunity to explore locoregional treatment practices between countries.
  
  
  METHODS
  Patients were enrolled in Belgium, France, Germany, Greece, Ireland, Japan, the Netherlands, the UK and the USA. The core protocol had minor differences in eligibility criteria between countries, reflecting variations in national guidelines and practice regarding adjuvant endocrine therapy.
  
  
  RESULTS
  Between 2001 and 2006, 9779 patients of mean(s.d.) age 64(9) years were randomized. Some 58.4 per cent had T1 tumours (range between countries 36.8-75.9 per cent; P < 0.001) and 47.3 per cent were axillary node positive (range 25.9-84.6 per cent; P < 0.001). Independent factors for type of breast surgery were country, age, tumour status and calendar year of surgery. After breast-conserving surgery, radiotherapy was given to 93.2 per cent of patients, 86.0 per cent in the USA and 100 per cent in France. Axillary lymph node dissection was performed in 82.0 (range 74.6-99.1) per cent.
  
  
  CONCLUSIONS
  Despite international consensus guidelines, wide global variations were observed in treatment practices of early breast cancer. There should be further efforts to optimize locoregional treatment for breast cancer worldwide.
authors.affiliation: Department of Surgery, Leiden University Medical Centre, Leiden, The Netherlands.
authors.forename: J G H
authors.initials: JG
authors.lastname: van Nes
authors.forename: C
authors.initials: C
authors.lastname: Seynaeve
authors.forename: S
authors.initials: S
authors.lastname: Jones
authors.forename: C
authors.initials: C
authors.lastname: Markopoulos
authors.forename: H
authors.initials: H
authors.lastname: Putter
authors.forename: C J H
authors.initials: CJ
authors.lastname: van de Velde
authors.forename: A
authors.initials: A
authors.lastname: Hasenburg
authors.forename: D W
authors.initials: DW
authors.lastname: Rea
authors.forename: J-M
authors.initials: JM
authors.lastname: Vannetzel
authors.forename: L
authors.initials: L
authors.lastname: Dirix
authors.forename: Y
authors.initials: Y
authors.lastname: Hozumi
authors.forename: M J
authors.initials: MJ
authors.lastname: Kerin
authors.forename: D G
authors.initials: DG
authors.lastname: Kieback
authors.forename: W M
authors.initials: WM
authors.lastname: Meershoek-Klein Kranenbarg
authors.forename: E T M
authors.initials: ET
authors.lastname: Hille
authors.forename: J W R
authors.initials: JW
authors.lastname: Nortier
mesh_terms: D000328:Adult; D000368:Aged; D000730:Androstadienes / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015992:Body Mass Index; D001943:Breast Neoplasms / Q000628:therapy*; D002985:Clinical Protocols; D003131:Combined Modality Therapy; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008408:Mastectomy / Q000706:statistics & numerical data; D008875:Middle Aged; D015337:Multicenter Studies as Topic / Q000379:methods / Q000706:statistics & numerical data; D018579:Patient Selection; D017698:Postmenopause; D016032:Randomized Controlled Trials as Topic / Q000379:methods / Q000706:statistics & numerical data; D013629:Tamoxifen / Q000008:administration & dosage
chemical_list: D000730:Androstadienes; D013629:Tamoxifen; C056516:exemestane