title: Determination and characterization of hydroxylated polychlorinated biphenyls (OH-PCBs) in serum and adipose tissue of Japanese women diagnosed with breast cancer.
abstract: In the present study, we analyze and characterize the levels of PCBs and OH-PCBs in serum and breast adipose tissue, and measure TH (total 3,5,5'-triiodothyronine (tT3) and total l-thyroxine (tT4)) levels in serum of Japanese women diagnosed with breast cancer (n = 51) to know how PCBs affect thyroid hormone homeostasis. Concentrations of Sigma(90)OH-PCBs in serum and adipose tissues were 630 pg g(-1) serum wet wt. and 140 pg/ g(-1) lipid wt., respectively, and the levels of OH-PCBs in adipose tissues were 4-5 times lower than in serum. The tT3 and tT4 concentrations in serum (n = 20) were 1.3 ng g(-1) serum wet wt. and 62 ng g(-1) serum wet wt., respectively. Among all the OH-PCBs, 4'-OH-CB101/120, 4-OH-CB107/4'-OH-CB108, 3'-OH-CB138, 4-OH-CB146, 3-OH-CB153, 4'-OH-CB172, and 4-OH-CB187 were the dominant isomers in serum. No significant correlation between the concentrations of the TH and OH-PCBs in serum was observed (p > 0.05). The results indicated that the relationship between the OH-PCB levels and the thyroid hormone markers was rare. From analysis of two kinds of human biological samples, it was estimated that OH-PCBs have little effect on thyroid hormone homeostasis.
authors.affiliation: Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Center for Marine Environmental Studies (CMES), Ehime University, Japan.
authors.forename: Kei
authors.initials: K
authors.lastname: Nomiyama
authors.forename: Tomonori
authors.initials: T
authors.lastname: Yonehara
authors.forename: Saori
authors.initials: S
authors.lastname: Yonemura
authors.forename: Megumi
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Chihaya
authors.initials: C
authors.lastname: Koriyama
authors.forename: Suminori
authors.initials: S
authors.lastname: Akiba
authors.forename: Ryota
authors.initials: R
authors.lastname: Shinohara
authors.forename: Minoru
authors.initials: M
authors.lastname: Koga
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D001943:Breast Neoplasms / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D006900:Hydroxylation; D007564:Japan; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000378:metabolism*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D011078:Polychlorinated Biphenyls; D013974:Thyroxine