Two new xanthones from Artocarpus obtusus.
Two new xanthones, pyranocycloartobiloxanthone A (1) and dihydroartoindonesianin C (2), were isolated from the stem bark of Artocarpus obtusus Jarrett by chromatographic separation. Their structures were determined by using spectroscopic methods and comparison with known related compounds. Pyranocycloartobiloxanthone A (1) showed strong free radical scavenging activity by using DPPH assay as well as cytotoxicity towards K562, HL-60, and MCF7 cell lines.
Hashim
Najihah
N
Department of Chemistry, Universiti Putra Malaysia 43400 UPM, Selangor, Malaysia.
Rahmani
Mawardi
M
Sukari
Mohd A
MA
Ali
Abdul M
AM
Alitheen
Noorjahan B
NB
Go
Rosea
R
Ismail
Hazar B M
HB
D031622:Artocarpus / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008296:Malaysia; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010851:Picrates / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D044004:Xanthones; C549170:dihydroartoindonesianin C; C549169:pyranocycloartobiloxanthone A; C004931:1,1-diphenyl-2-picrylhydrazyl