Oxytocin receptor gene and depressive symptoms associated with physiological reactivity to infant crying.
Both the oxytocin receptor (OXTR) gene and depressive symptoms have been associated with parenting behaviour. The OXTR GG genotype has been suggested to be related to more sensitive parenting, whereas depressive symptoms may affect sensitivity negatively. We examined the role of OXTR and the influence of depressive symptoms in explaining differences in physiological reactivity to infant crying. Heart rate responses of 40 healthy females without children (age 19-47 years, randomly selected half of twin pairs) were measured during the presentation of three episodes of infant cry sounds. Participants with the presumably more efficient variant of the oxytonergic system gene (OXTR GG) had more pronounced physiological reactivity to repeated cry sounds, except when they showed more symptoms of depression. Results were replicated in the second half of the twin sample. This is the first study to suggest effects of OXTR genotype on physiological reactivity to infant crying. Depressive symptoms may however suppress the effect of the OXTR GG genotype.
Riem
Madelon M E
MM
Centre for Child and Family Studies, Leiden University, 2300 RB Leiden, the Netherlands.
Pieper
Suzanne
S
Out
Dorothée
D
Bakermans-Kranenburg
Marian J
MJ
van Ijzendoorn
Marinus H
MH
D000161:Acoustic Stimulation / Q000379:methods; D000328:Adult; D003448:Crying; D003863:Depression / Q000235:genetics* / Q000503:physiopathology*; D005260:Female; D005838:Genotype; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007223:Infant; D008875:Middle Aged; D016487:Parenting; D011897:Random Allocation; D018045:Receptors, Oxytocin / Q000235:genetics* / Q000502:physiology; D055815:Young Adult
D018045:Receptors, Oxytocin
Clin Genet. 1983 Aug;24(2):103-12
6577993
Child Dev. 1996 Oct;67(5):2512-26
9022253
Ann N Y Acad Sci. 2007 Mar;1098:312-22
17435137
Arch Dis Child. 1997 Aug;77(2):99-101
9301345
Soc Cogn Affect Neurosci. 2008 Jun;3(2):128-34
19015103
Dev Psychobiol. 2003 Sep;43(2):109-19
12918090
Psychol Sci. 2007 Nov;18(11):965-70
17958710
Psychoneuroendocrinology. 2010 Sep;35(8):1133-41
20153585
J Clin Psychiatry. 2005;66 Suppl 8:22-9
16336033
J Child Psychol Psychiatry. 1993 Oct;34(7):1083-101
8245134
Soc Cogn Affect Neurosci. 2008 Jun;3(2):89-90
19015099
Psychoneuroendocrinology. 1998 Nov;23(8):779-818
9924738
J Child Psychol Psychiatry. 2007 Mar-Apr;48(3-4):329-54
17355401
Dev Psychobiol. 2001 Dec;39(4):265-85
11745323
Child Dev. 1988 Aug;59(4):1089-96
3168616
Biol Psychiatry. 2005 Jul 1;58(1):74-7
15992526
Dev Psychol. 2004 Nov;40(6):1133-47
15535762
Infancy. 2001 Oct;2(4):483-499
33451195
Infant Behav Dev. 2009 Jan;32(1):117-22
19081636
Child Dev. 1980 Mar;51(1):238-41
7363736
Psychol Bull. 1979 Jan;86(1):191-215
377352
Child Abuse Negl. 1992;16(1):19-29
1544026
J Abnorm Child Psychol. 1987 Sep;15(3):361-78
3668084