Myosin binding protein-C slow: an intricate subfamily of proteins.
Myosin binding protein C (MyBP-C) consists of a family of thick filament associated proteins. Three isoforms of MyBP-C exist in striated muscles: cardiac, slow skeletal, and fast skeletal. To date, most studies have focused on the cardiac form, due to its direct involvement in the development of hypertrophic cardiomyopathy. Here we focus on the slow skeletal form, discuss past and current literature, and present evidence to support that: (i) MyBP-C slow comprises a subfamily of four proteins, resulting from complex alternative shuffling of the single MyBP-C slow gene, (ii) the four MyBP-C slow isoforms are expressed in variable amounts in different skeletal muscles, (iii) at least one MyBP-C slow isoform is preferentially found at the periphery of M-bands and (iv) the MyBP-C slow subfamily may play important roles in the assembly and stabilization of sarcomeric M- and A-bands and regulate the contractile properties of the actomyosin filaments.
Ackermann
Maegen A
MA
Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, Baltimore, MD 21201, USA.
Kontrogianni-Konstantopoulos
Aikaterini
A
D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D020033:Protein Isoforms; D000099163:Myosin Binding Protein C
D002352:Carrier Proteins; D020033:Protein Isoforms; D000099163:Myosin Binding Protein C
Physiol Genomics. 2005 Apr 14;21(2):131-43
15831843
J Biochem. 1986 Apr;99(4):1037-47
3519599
Biophys J. 1979 Sep;27(3):433-46
263692
J Appl Physiol (1985). 2007 Dec;103(6):2105-11
17916670
J Histochem Cytochem. 1975 Jul;23(7):543-62
1095653
J Mol Cell Cardiol. 1995 Oct;27(10):2275-86
8576942
Eur J Biochem. 1993 Sep 1;216(2):661-9
8375400
J Cell Sci. 1993 Jan;104 ( Pt 1):119-23
8449991
J Biol Chem. 1997 Aug 15;272(33):20866-72
9252413
Acta Biochim Biophys Hung. 1986;21(3):247-56
2879405
J Muscle Res Cell Motil. 2005;26(6-8):419-26
16625317
Annu Rev Cell Dev Biol. 2002;18:637-706
12142273
J Biol Chem. 2006 Mar 17;281(11):7666-83
16407297
Soc Gen Physiol Ser. 1996;51:3-18
8809930
Arch Biochem Biophys. 1993 Aug 1;304(2):305-9
8346908
Circ Res. 1999 May 28;84(10):1117-26
10347086
Circ Res. 1998 Jan 9-23;82(1):130-3
9440712
Cardiovasc Res. 2004 Aug 1;63(2):293-304
15249187
FEBS Lett. 1986 Nov 10;208(1):123-7
3770206
J Cell Biol. 1981 Jul;90(1):25-31
6788782
Circ Res. 2003 Oct 17;93(8):752-8
14500336
J Muscle Res Cell Motil. 2005;26(2-3):143-8
16003462
Biochem Cell Biol. 1986 Jul;64(7):622-30
3755998
Circ Res. 2006 May 26;98(10):1234-6
16728667
Pflugers Arch. 1974 Apr 22;348(3):247-55
4275915
J Physiol. 1991 Aug;439:701-15
1895247
Eur J Biochem. 1995 Jun 1;230(2):752-9
7607248
Mol Biol Cell. 2009 Jun;20(12):2963-78
19403693
Dev Biol. 1984 Sep;105(1):253-6
6381176
Muscle Nerve. 1999 Feb;22(2):196-207
10024132
FEBS Lett. 1971 Jun 2;15(1):40-44
11945810
J Histochem Cytochem. 1993 May;41(5):733-43
8468455
Circ Res. 2004 May 28;94(10):1279-89
15166115
J Mol Biol. 2008 Mar 21;377(2):307-10
18262203
Tissue Cell. 1986;18(4):499-508
3755847
Circ Res. 2004 Oct 29;95(9):930-6
15472117
J Cell Sci. 1992 Aug;102 ( Pt 4):769-78
1429890
J Muscle Res Cell Motil. 1999 Oct;20(7):703-15
10672519
J Cell Biol. 1993 Nov;123(3):619-26
8227129
Biochem J. 1978 Jun 1;171(3):813-6
352343
Nat New Biol. 1973 Aug 1;244(135):152-4
4516378
J Muscle Res Cell Motil. 1986 Dec;7(6):550-67
3543050
Int J Biochem Cell Biol. 2007;39(12):2161-6
17320463
Acta Histochem. 2002;104(4):399-405
12553710
Biochim Biophys Acta. 1980 Oct 1;632(2):141-9
6448079
J Mol Cell Cardiol. 2010 Jun;48(6):1266-79
19913549
Biofizika. 2003 May-Jun;48(3):499-504
12815860
J Mol Biol. 1978 Oct 5;124(4):571-86
152359
J Cell Sci. 1999 Jan;112 ( Pt 1):69-79
9841905
J Mol Biol. 1975 Sep 5;97(1):1-9
1100851
Circ Res. 1998 Jan 9-23;82(1):124-9
9440711
J Physiol. 2003 Nov 1;552(Pt 3):833-44
12937290
J Muscle Res Cell Motil. 1988 Apr;9(2):174-83
3417855
Physiol Rev. 2009 Oct;89(4):1217-67
19789381
J Mol Biol. 2009 Oct 16;393(1):10-26
19683008
Muscle Nerve. 1987 May;10(4):351-8
3587270
J Mol Biol. 1973 Mar 15;74(4):653-76
4269687
FEBS Lett. 2008 Feb 6;582(3):434-8
18201573
Cell Res. 2004 Apr;14(2):95-110
15115610
Nat Genet. 1995 Dec;11(4):438-40
7493026
EMBO J. 1992 May;11(5):1711-6
1582406
J Cell Biol. 1983 Jan;96(1):297-300
6687470
Circ Res. 2002 Mar 22;90(5):594-601
11909824
Dev Biol. 1984 Jan;101(1):116-24
6141116
J Cell Sci. 1996 Jan;109 ( Pt 1):101-11
8834795
Eur J Biochem. 1996 Jan 15;235(1-2):317-23
8631348
Proc Natl Acad Sci U S A. 1990 Mar;87(6):2157-61
2315308
Proc R Soc Lond B Biol Sci. 1976 Mar 16;192(1109):451-61
4802
J Cell Biol. 1985 Jan;100(1):208-15
3838095
Arch Mal Coeur Vaiss. 2007 Mar;100(3):238-43
17536430
J Anat. 1994 Aug;185 ( Pt 1):95-101
7559119
Am J Physiol. 1994 Aug;267(2 Pt 1):C443-9
8074179