title: [Association between multi-noninvasive indexes and mild coronary stenosis].
abstract: OBJECTIVE
  To observe the changes of multi-noninvasive indexes including endothelial function, arterial flexibility, carotid intima-media thickness (IMT) and serum inflammatory cytokines in patients with mild coronary stenosis.
  
  
  METHODS
  One hundred and five patients were divided into three groups according to the result of coronary angiography: coronary heart disease (stenosis > or = 50% in at least one coronary segment), mild coronary stenosis (stenosis < 50% in at least one coronary segment) and control group (normal coronary). Brachial-ankle pulse wave velocity (baPWV) and ankle-brachial index (ABI), reflecting arterial flexibility and the lower extremity vascular disease respectively, were measured by a Colin system, carotid artery IMT was detected echocardiographically. Serum levels of NO, vWF, hs-CRP were measured before coronary angiography in all patients.
  
  
  RESULTS
  baPWV [(1482 +/- 155) cm/s vs. (1249 +/- 158) cm/s] and carotid IMT [(0.88 +/- 0.18) mm vs. (0.72 +/- 0.20) mm] were significantly higher while serum levels of NO [(64 +/- 17) micromol/L vs. (83 +/- 17) micromol/L] was significantly lower in mild coronary stenosis group than those in control group (all P < 0.05). vWF, ABI and hs-CRP were similar between the two groups (all P > 0.05). Logistic regression analysis showed that NO, baPWV, smoking are independent predicting factors for mild coronary stenosis (all P < 0.05).
  
  
  CONCLUSIONS
  Endothelial dysfunction, reduction of the arterial flexibility as well as increased serum inflammation were associated with mild coronary stenosis.
authors.affiliation: Department of Cardiology, Guangzhou General Hospital of Guangzhou Military Command, Guangzhou 510010, China.
authors.forename: Li-gen
authors.initials: LG
authors.lastname: Du
authors.forename: Jian
authors.initials: J
authors.lastname: Qiu
authors.forename: Yun-jun
authors.initials: YJ
authors.lastname: Ruan
authors.forename: Feng-ying
authors.initials: FY
authors.lastname: Dong
authors.forename: Chang-jiang
authors.initials: CJ
authors.lastname: Hong
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: Lin
authors.initials: L
authors.lastname: Xu
mesh_terms: D000368:Aged; D002339:Carotid Arteries / Q000503:physiopathology*; D017023:Coronary Angiography; D023921:Coronary Stenosis / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology*; D004548:Elasticity; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged