title: The role of cardiac magnetic resonance imaging in differentiating the underlying causes of left ventricular hypertrophy.
abstract: The onset of sudden cardiac death and large inter- and intra-familial clinical variability of hypertrophic cardiomyopathy pose an important clinical challenge. Cardiac magnetic resonance imaging is a high-resolution imaging modality that has become increasingly available in the past decade and has the unique possibility to demonstrate the presence of fibrosis or scar using late gadolinium enhancement imaging. As a result, the diagnostic and prognostic potential of cardiac magnetic resonance imaging has been extensively explored in acute and chronic ischaemic cardiomyopathy, as well as in several nonischaemic cardiomyopathies.This review aims to provide a critical overview of recently published studies on hypertrophic cardiomyopathy and discusses the role of cardiac magnetic resonance imaging in differentiating underlying causes of hypertrophic cardiomyopathy, such as familial hypertrophic cardiomyopathy, cardiac involvement in systemic disease and left ventricular hypertrophy due to endurance sports. Also, it demonstrates the use of cardiac magnetic resonance in risk stratification for the onset of sudden cardiac death, and early identification of asymptomatic family members of hypertrophic cardiomyopathy patients who are at risk for the development of hypertrophic cardiomyopathy. (Neth Heart J 2010;18:135-43.).
authors.affiliation: VU University Medical Center, Amsterdam, the Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Germans
authors.forename: R
authors.initials: R
authors.lastname: Nijveldt
authors.forename: W P
authors.initials: WP
authors.lastname: Brouwer
authors.forename: J G J
authors.initials: JG
authors.lastname: Groothuis
authors.forename: A M
authors.initials: AM
authors.lastname: Beek
authors.forename: M J W
authors.initials: MJ
authors.lastname: Götte
authors.forename: A C
authors.initials: AC
authors.lastname: van Rossum
references.citation: J Cardiovasc Magn Reson. 2005;7(3):551-8
references.pmid: 15959967
references.citation: Am J Cardiol. 2004 Dec 1;94(11):1391-5
references.pmid: 15566909
references.citation: J Am Coll Cardiol. 2006 Nov 21;48(10):2002-11
references.pmid: 17112990
references.citation: Eur Heart J. 2001 Dec;22(23):2171-9
references.pmid: 11913479
references.citation: J Am Coll Cardiol. 2007 Sep 25;50(13):1294-5
references.pmid: 17888849
references.citation: Kidney Int. 2006 Mar;69(5):846-51
references.pmid: 16518344
references.citation: Am J Cardiol. 2009 Feb 15;103(4):544-9
references.pmid: 19195518
references.citation: Heart. 2000 Nov;84(5):476-82
references.pmid: 11040002
references.citation: Eur J Haematol. 2005 Sep;75(3):241-7
references.pmid: 16104881
references.citation: Int J Cardiol. 2008 Jun 6;126(3):e50-2
references.pmid: 17399811
references.citation: J Am Coll Cardiol. 2006 Jan 17;47(2):384-90
references.pmid: 16412865
references.citation: Circulation. 2005 Jan 18;111(2):186-93
references.pmid: 15630027
references.citation: J Am Coll Cardiol. 2005 Apr 5;45(7):1109-16
references.pmid: 15808772
references.citation: J Nucl Med. 2005 Jun;46(6):923-9
references.pmid: 15937301
references.citation: J Am Coll Cardiol. 2000 Dec;36(7):2212-8
references.pmid: 11127463
references.citation: N Engl J Med. 1998 Aug 13;339(7):417-23
references.pmid: 9700174
references.citation: Eur Heart J. 2005 Aug;26(15):1461-74
references.pmid: 15831557
references.citation: Eur Heart J. 2008 Jan;29(2):270-6
references.pmid: 17916581
references.citation: Neth Heart J. 2007;15(4):161-3
references.pmid: 18604279
references.citation: Eur Heart J. 2009 Nov;30(21):2593-8
references.pmid: 19666645
references.citation: Diabetes Care. 2006 Mar;29(3):588-94
references.pmid: 16505511
references.citation: J Am Coll Cardiol. 2003 May 7;41(9):1561-7
references.pmid: 12742298
references.citation: J Am Coll Cardiol. 2008 Apr 8;51(14):1369-74
references.pmid: 18387438
references.citation: J Am Coll Cardiol. 2006 Dec 19;48(12):2518-23
references.pmid: 17174192
references.citation: J Cardiovasc Magn Reson. 2008 Nov 25;10:54
references.pmid: 19032744
references.citation: Circulation. 2001 Jul 10;104(2):128-30
references.pmid: 11447072
references.citation: Am Heart J. 2002 Aug;144(2):198-205
references.pmid: 12177633
references.citation: Ann Med Interne (Paris). 2000 Dec;151(8):611-7
references.pmid: 11173703
references.citation: Am J Med. 1978 Apr;64(4):547-55
references.pmid: 645720
references.citation: Neth Heart J. 2010 Mar;18(3):135-43
references.pmid: 20390064
references.citation: Magn Reson Imaging. 2004 Feb;22(2):155-61
references.pmid: 15010107
references.citation: J Am Coll Cardiol. 2002 Dec 18;40(12):2156-64
references.pmid: 12505229
references.citation: J Cardiovasc Magn Reson. 2006;8(3):479-82
references.pmid: 16755835
references.citation: Circulation. 2007 Jun 5;115(22):e610-1
references.pmid: 17548735
references.citation: J Am Coll Cardiol. 2004 Jun 16;43(12):2260-4
references.pmid: 15193690
references.citation: JACC Cardiovasc Imaging. 2009 Jan;2(1):58-64
references.pmid: 19356534
references.citation: J Am Soc Nephrol. 1995 Jun;5(12):2024-31
references.pmid: 7579050
references.citation: Circulation. 2005 Aug 9;112(6):855-61
references.pmid: 16087809
references.citation: J Am Coll Cardiol. 2003 Jul 16;42(2):328-35
references.pmid: 12875772
references.citation: Circulation. 1980 Aug;62(2):218-29
references.pmid: 6446987
references.citation: N Engl J Med. 1995 Aug 3;333(5):288-93
references.pmid: 7596372
references.citation: J Am Coll Cardiol. 2004 Feb 4;43(3):410-5
references.pmid: 15013123
references.citation: Radiology. 2007 Mar;242(3):647-9
references.pmid: 17213364
references.citation: Blood. 1999 Feb 1;93(3):1062-6
references.pmid: 9920856
references.citation: Mol Cell Biochem. 1998 Mar;180(1-2):53-7
references.pmid: 9546630
references.citation: QJM. 1998 Feb;91(2):141-57
references.pmid: 9578896
references.citation: Kidney Int. 2006 May;69(10):1839-45
references.pmid: 16508657
references.citation: Circulation. 2002 Mar 26;105(12):1407-11
references.pmid: 11914245