Effect of lead toxicity on coenzyme Q levels in rat tissues.
Lead is a persistent and common environmental contaminant, which chiefly plays a significant role in modern industry. Coenzyme Q acts as electron and proton carrier in mitochondria and functions as an antioxidant in its reduced form (ubiquinol). To investigate the hazardous effects of lead on the coenzyme Q level, rats were injected i.p. with lead acetate (5 mg/kg b.wt. daily for 6 weeks). Our results showed that the levels of both oxidized (ubiquinone) and reduced (ubiquinol) forms of coenzyme Q(9) and Q(10) in serum, brain, liver and kidney of lead-treated rats are quite different depending on the organ tissue type.
Abdallah
Gamil M
GM
Biochemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr-City, Cairo, Egypt.
El-Sayed
El-Sayed M
el-SM
Abo-Salem
Osama M
OM
D000818:Animals; D007854:Lead / Q000633:toxicity*; D008297:Male; D051381:Rats; D014451:Ubiquinone / Q000378:metabolism*
D014451:Ubiquinone; D007854:Lead