title: Application of the gene dosage balance hypothesis to auxin-related ribosomal mutants in Arabidopsis.
abstract: Several proteomic studies in Arabidopsis have shown the presence of heterogeneous ribosomal populations in different tissues. However, the phenotypic consequences of the imbalance of those ribosomal populations, and the regulatory mechanisms activated to control specific ratios between them, have yet to be evaluated. In our previous report, the phenotypic characterization of the ribosomal protein family L4 (RPL4) in Arabidopsis suggests that the maintenance of proper auxin-regulated developmental responses requires the simultaneous presence of RPL4A- and RPL4D-containing ribosomes. Based on the analysis of the compensatory mechanisms within the RPL4 family proteins in the rpl4a and rpl4d backgrounds, we propose the Gene Dosage Balance Hypothesis (GDBH) as a regulatory mechanism for ribosomal complexes in Arabidopsis. By using the concepts of dosage compensation and hierarchy, GDBH is able to explain the severity and specificity of different ribosomal mutant phenotypes associated with the same ribosomal complex.
authors.affiliation: Institute for Integrative Genome Biology, Center for Plant Cell Biology, Department of Botany and Plant Sciences, University of California, Riverside, CA, USA.
authors.forename: Abel
authors.initials: A
authors.lastname: Rosado
authors.forename: Natasha V
authors.initials: NV
authors.lastname: Raikhel
references.citation: Plant Physiol. 2001 Oct;127(2):398-415
references.pmid: 11598216
references.citation: Development. 2008 Apr;135(7):1315-24
references.pmid: 18305008
references.citation: Annu Rev Biochem. 2001;70:703-54
references.pmid: 11395421
references.citation: Plant Cell. 2005 Nov;17(11):2940-53
references.pmid: 16227452
references.citation: Adv Genet. 1998;38:69-134
references.pmid: 9677706
references.citation: Nature. 2003 Jul 10;424(6945):194-7
references.pmid: 12853957
references.citation: J Theor Biol. 2003 Jan 7;220(1):19-25
references.pmid: 12453447
references.citation: Plant J. 2000 May;22(3):257-64
references.pmid: 10849343
references.citation: Dev Biol. 2001 Jun 15;234(2):275-88
references.pmid: 11396999
references.citation: Plant Physiol. 2008 May;147(1):128-42
references.pmid: 18322146
references.citation: Plant Cell. 2005 Jan;17(1):4-11
references.pmid: 15632052
references.citation: Plant J. 1996 Sep;10(3):479-89
references.pmid: 8811862
references.citation: Plant Mol Biol. 2005 Mar;57(4):577-91
references.pmid: 15821981
references.citation: Genes Dev. 2001 May 1;15(9):1104-14
references.pmid: 11331606
references.citation: Bioinformatics. 2005 Dec 15;21(24):4411-3
references.pmid: 16223790
references.citation: Trends Genet. 2008 Aug;24(8):390-7
references.pmid: 18585818
references.citation: Plant Cell. 2010 Jan;22(1):143-58
references.pmid: 20061553
references.citation: EMBO J. 1994 Jul 15;13(14):3378-88
references.pmid: 7913892
references.citation: Development. 2008 Apr;135(7):1325-34
references.pmid: 18305007
references.citation: Curr Opin Genet Dev. 1998 Jun;8(3):322-7
references.pmid: 9690998
references.citation: Development. 2001 Nov;128(21):4289-99
references.pmid: 11684664