Simultaneous electrochemical detection of both PSMA (+) and PSMA (-) prostate cancer cells using an RNA/peptide dual-aptamer probe.
Using an RNA/peptide dual-aptamer probe, both PSMA (+) and PSMA (-) prostate cancer cells were simultaneously detected by electrochemical impedance spectroscopy. This approach can be applied as a general tool for early diagnosis of prostate cancer.
Min
Kyoungin
K
Department of Chemistry, Pohang University of Science and Technology, San31, Hyoja-dong, Pohang, Gyungbuk, 790-784, South Korea.
Song
Kyung-Mi
KM
Cho
Minseon
M
Chun
Yang-Sook
YS
Shim
Yoon-Bo
YB
Ku
Ja Kang
JK
Ban
Changill
C
D000595:Amino Acid Sequence; D000954:Antigens, Surface / Q000032:analysis*; D052157:Aptamers, Nucleotide / Q000737:chemistry*; D052158:Aptamers, Peptide / Q000737:chemistry*; D001483:Base Sequence; D045744:Cell Line, Tumor; D043425:Glutamate Carboxypeptidase II / Q000032:analysis*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D012680:Sensitivity and Specificity
D000954:Antigens, Surface; D052157:Aptamers, Nucleotide; D052158:Aptamers, Peptide; C473848:FOLH1 protein, human; D043425:Glutamate Carboxypeptidase II