title: Photoacoustic ophthalmoscopy for in vivo retinal imaging.
abstract: We have developed a non-invasive photoacoustic ophthalmoscopy (PAOM) for in vivo retinal imaging. PAOM detects the photoacoustic signal induced by pulsed laser light shined onto the retina. By using a stationary ultrasonic transducer in contact with the eyelids and scanning only the laser light across the retina, PAOM provides volumetric imaging of the retinal micro-vasculature and retinal pigment epithelium at a high speed. For B-scan frames containing 256 A-lines, the current PAOM has a frame rate of 93 Hz, which is comparable with state-of-the-art commercial spectral-domain optical coherence tomography (SD-OCT). By integrating PAOM with SD-OCT, we further achieved OCT-guided PAOM, which can provide multi-modal retinal imaging simultaneously. The capabilities of this novel technology were demonstrated by imaging both the microanatomy and microvasculature of the rat retina in vivo.
authors.affiliation: Department of Ophthalmology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
authors.forename: Shuliang
authors.initials: S
authors.lastname: Jiao
authors.forename: Minshan
authors.initials: M
authors.lastname: Jiang
authors.forename: Jianming
authors.initials: J
authors.lastname: Hu
authors.forename: Amani
authors.initials: A
authors.lastname: Fawzi
authors.forename: Qifa
authors.initials: Q
authors.lastname: Zhou
authors.forename: K Kirk
authors.initials: KK
authors.lastname: Shung
authors.forename: Carmen A
authors.initials: CA
authors.lastname: Puliafito
authors.forename: Hao F
authors.initials: HF
authors.lastname: Zhang
mesh_terms: D000162:Acoustics / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D012160:Retina / Q000033:anatomy & histology*; D042261:Retinoscopes
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