Lack of association of PON polymorphisms with sporadic ALS in an Italian population.
Paraoxonase (PON) gene polymorphisms have been associated with susceptibility to sporadic amyotrophic lateral sclerosis (ALS). We have investigated the role of the previously associated single nucleotide polymorphisms rs854560, rs662, and rs6954345 in 350 ALS patients and 376 matched controls from Italy. No significant association was observed at genotype and haplotype level. Our data suggest that PON polymorphisms are not involved in ALS pathogenesis in an Italian population.
Ricci
Claudia
C
Department of Neuroscience-Neurology Section, University of Siena, Siena, Italy.
Battistini
Stefania
S
Cozzi
Lorena
L
Benigni
Michele
M
Origone
Paola
P
Verriello
Lorenzo
L
Lunetta
Christian
C
Cereda
Cristina
C
Milani
Pamela
P
Greco
Giuseppe
G
Patrosso
Maria Cristina
MC
Causarano
Renzo
R
Caponnetto
Claudia
C
Giannini
Fabio
F
Corbo
Massimo
M
Penco
Silvana
S
D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics*; D043303:Aryldialkylphosphatase / Q000235:genetics*; D016009:Chi-Square Distribution; D004252:DNA Mutational Analysis; D005260:Female; D005838:Genotype; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
D043303:Aryldialkylphosphatase; C468406:PON1 protein, human