title: Low vitamin D status is associated with physical inactivity, obesity and low vitamin D intake in a large US sample of healthy middle-aged men and women.
abstract: The aim of this study was to investigate modifiable predictors of vitamin D status in healthy individuals, aged 55-74, and living across the USA. Vitamin D status [serum 25-hydroxyvitamin D (25(OH)D)] was measured along with age and season at blood collection, demographics, anthropometry, physical activity (PA), diet, and other lifestyle factors in 1357 male and 1264 female controls selected from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) cohort. Multivariate linear and logistic regression analyses were used to identify associations with vitamin D status. Three%, 29% and 79% of the population had serum 25(OH)D levels<25, <50 and <80 nmol/L, respectively. The major modifiable predictors of low vitamin D status were low vitamin D dietary and supplement intake, body mass index (BMI) >30 kg/m2, physical inactivity (PA) and low milk and calcium supplement intake. In men, 25(OH)D was determined more by milk intake on cereal and in women, by vitamin D and calcium supplement and menopausal hormone therapy (MHT) use. Thus targeting an increase in vigorous activity and vitamin D and calcium intake and decreasing obesity could be public health interventions independent of sun exposure to improve vitamin D status in middle-aged Americans.
authors.affiliation: Faculty of Health Sciences, University of Sydney (USyd), East Street (PO Box 170), Lidcombe, Sydney, NSW, Australia. K.Brock@usyd.edu.au
authors.forename: K
authors.initials: K
authors.lastname: Brock
authors.forename: W-Y
authors.initials: WY
authors.lastname: Huang
authors.forename: D R
authors.initials: DR
authors.lastname: Fraser
authors.forename: L
authors.initials: L
authors.lastname: Ke
authors.forename: M
authors.initials: M
authors.lastname: Tseng
authors.forename: R
authors.initials: R
authors.lastname: Stolzenberg-Solomon
authors.forename: U
authors.initials: U
authors.lastname: Peters
authors.forename: J
authors.initials: J
authors.lastname: Ahn
authors.forename: M
authors.initials: M
authors.lastname: Purdue
authors.forename: R S
authors.initials: RS
authors.lastname: Mason
authors.forename: C
authors.initials: C
authors.lastname: McCarty
authors.forename: R G
authors.initials: RG
authors.lastname: Ziegler
authors.forename: B
authors.initials: B
authors.lastname: Graubard
mesh_terms: D000368:Aged; D015992:Body Mass Index; D002118:Calcium / Q000627:therapeutic use; D016022:Case-Control Studies; D015331:Cohort Studies; D004032:Diet; D019587:Dietary Supplements; D005260:Female; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008593:Menopause; D008875:Middle Aged; D009043:Motor Activity; D009765:Obesity / Q000097:blood*; D012621:Seasons; D014481:United States; D014807:Vitamin D / Q000008:administration & dosage* / Q000097:blood* / Q000378:metabolism*
chemical_list: D006728:Hormones; D014807:Vitamin D; D002118:Calcium
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