Day-5 inhibin B serum concentrations and antral follicle count as predictors of ovarian response and live birth in assisted reproduction cycles stimulated with gonadotropin after pituitary suppression.
OBJECTIVE
To investigate the usefulness of day-5 inhibin B and antral follicle count (AFC) in predicting ovarian response and live birth in the first cycle of assisted reproduction.


METHODS
Prospective cohort study.


METHODS
University hospital.


METHODS
Ninety-eight infertile women treated with in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) comprising 72 normal responders and 26 poor responders.


METHODS
Ovarian stimulation with gonadotropin-releasing hormone agonist-gonadotropin treatment.


METHODS
Basal ultrasonographic (AFC, total ovarian volume) and basal (follicle-stimulating hormone, estradiol, and inhibin B) and stimulation day-5 (estradiol, inhibin B) hormone parameters.


RESULTS
The AFC had the best predictive value among the basal variables for outcome of ovarian stimulation. Among the dynamic hormone measurements, day-5 inhibin serum measurement emerged as the best predictive variable of poor response in IVF-ICSI cycles, but it was not statistically significantly better than basal AFC. The association of day-5 inhibin B with live-birth rate was statistically significant and stronger than the effect of any other variable investigated.


CONCLUSIONS
Basal AFC and day-5 inhibin B have similar predictive properties for ovarian response in assisted reproduction cycles stimulated with gonadotropin after pituitary suppression, but day-5 inhibin B is a superior predictor of live birth.
Peñarrubia
Joana
J
Institut Clínic of Gynecology, Obstetrics, and Neonatology, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
Peralta
Sara
S
Fábregues
Francisco
F
Carmona
Francisco
F
Casamitjana
Roser
R
Balasch
Juan
J
D000328:Adult; D002452:Cell Count; D015536:Down-Regulation / Q000187:drug effects; D005260:Female; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007246:Infertility / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D007265:Inhibins / Q000032:analysis / Q000097:blood*; D050498:Live Birth / Q000453:epidemiology; D009994:Osmolar Concentration; D006080:Ovarian Follicle / Q000187:drug effects / Q000473:pathology*; D010062:Ovulation Induction / Q000379:methods; D010902:Pituitary Gland / Q000187:drug effects / Q000502:physiology; D011247:Pregnancy; D011379:Prognosis; D027724:Reproductive Techniques, Assisted; D013997:Time Factors
D006062:Gonadotropins; C422364:inhibin B; D007265:Inhibins