title: The Biomarkers Consortium: practice and pitfalls of open-source precompetitive collaboration.
abstract: Precompetitive collaboration is a growing driver for innovation and increased productivity in biomedical science and drug development. The Biomarkers Consortium, a public-private platform for precompetitive collaboration specific to biomarkers, demonstrated that adiponectin has potential utility as a predictor of metabolic responses to peroxisome proliferator-activated receptor (PPAR) agonists in individuals with type 2 diabetes. Despite the challenges overcome by this project, the most important lesson learned is that cross-company precompetitive collaboration is a feasible robust approach to biomarker qualification.
authors.affiliation: Merck, Rahway, New Jersey, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Wagner
authors.forename: M
authors.initials: M
authors.lastname: Prince
authors.forename: E C
authors.initials: EC
authors.lastname: Wright
authors.forename: M M
authors.initials: MM
authors.lastname: Ennis
authors.forename: J
authors.initials: J
authors.lastname: Kochan
authors.forename: D J R
authors.initials: DJ
authors.lastname: Nunez
authors.forename: B
authors.initials: B
authors.lastname: Schneider
authors.forename: M-D
authors.initials: MD
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Ghosh
authors.forename: B J
authors.initials: BJ
authors.lastname: Musser
authors.forename: M T
authors.initials: MT
authors.lastname: Vassileva
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D003299:Cooperative Behavior; D016503:Drug Delivery Systems / Q000379:methods / Q000639:trends; D015195:Drug Design; D004345:Drug Industry / Q000191:economics / Q000379:methods / Q000639:trends; D004465:Economic Competition / Q000191:economics / Q000639:trends; D006801:Humans; D016032:Randomized Controlled Trials as Topic / Q000639:trends
chemical_list: D015415:Biomarkers