title: Persistent pulmonary hypertension of the newborn refractory to inhaled nitric oxide-treated with milrinone: a case report.
abstract: Current therapy of persistent pulmonary hypertension of the newborn (PPHN) consists of optimal ventilation, hemodynamic support and selective vasodilatation with inhaled nitric oxide (iNO). We present herein a case of PPHN non-responsive to iNO but treated successfully with a combination of iNO and intravenous milrinone, a phosphodiesterase III inhibitor. This case suggests that the drug may be a useful adjunctive treatment in the management of PPHN.
authors.affiliation: Neonatal Intensive Care Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
authors.forename: Chryssoula
authors.initials: C
authors.lastname: Tzialla
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Cerbo
authors.forename: Gianfranco
authors.initials: G
authors.lastname: Perotti
authors.forename: Mauro
authors.initials: M
authors.lastname: Stronati
mesh_terms: D006801:Humans; D007231:Infant, Newborn; D020105:Milrinone / Q000627:therapeutic use*; D009569:Nitric Oxide / Q000008:administration & dosage*; D010547:Persistent Fetal Circulation Syndrome / Q000188:drug therapy*; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D017211:Treatment Failure
chemical_list: D010726:Phosphodiesterase Inhibitors; D009569:Nitric Oxide; D020105:Milrinone