title: Synthesis of novel benzocoumarin derivatives as lipid lowering agents.
abstract: A series of novel benzocoumarin derivatives were synthesized and evaluated for their in vivo anti-dyslipidemic and in vitro antioxidant activities. Preliminary screening indicates compound 4 as potential lead with significant lipid lowering and antioxidant activities. The study revealed that such attempts on benzocoumarin-based pharmacophores which is a biologically important scaffold might result in identification of new lead for anti-dyslipidemia.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226 001, India. sashidhar123@gmail.com
authors.forename: Koneni V
authors.initials: KV
authors.lastname: Sashidhara
authors.forename: Jammikuntla N
authors.initials: JN
authors.lastname: Rosaiah
authors.forename: Abdhesh
authors.initials: A
authors.lastname: Kumar
authors.forename: Gitika
authors.initials: G
authors.lastname: Bhatia
authors.forename: A K
authors.initials: AK
authors.lastname: Khanna
mesh_terms: D000818:Animals; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry* / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D013329:Structure-Activity Relationship
chemical_list: C551142:7-benzyloxy-4-methyl-benzo(h)chromen-2-one; D003374:Coumarins; D000960:Hypolipidemic Agents; C030123:coumarin