title: Correction of endothelial dysfunction with impaza preparation in complex with enalapril and losartan during modeling of NO deficiency.
abstract: Modeling of NO deficiency by administration of L-NAME to rats led to the development of arterial hypertension and endothelial dysfunction. Pronounced endothelium and cardioprotective effects of impaza under these experimental conditions manifested more markedly during combined administration of the preparation with standard hypotensive preparations enalapril and losartan.
authors.affiliation: Kursk State Medical University, Federal Agency for Health Care and Social Development.
authors.forename: A S
authors.initials: AS
authors.lastname: Belous
authors.forename: M V
authors.initials: MV
authors.lastname: Pokrovskii
authors.forename: T G
authors.initials: TG
authors.lastname: Pokrovskaya
authors.forename: V I
authors.initials: VI
authors.lastname: Kochkarov
authors.forename: E B
authors.initials: EB
authors.lastname: Artyushkova
authors.forename: E N
authors.initials: EN
authors.lastname: Pashin
authors.forename: E S
authors.initials: ES
authors.lastname: Zhavbert
mesh_terms: D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D004656:Enalapril / Q000627:therapeutic use*; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D019808:Losartan / Q000627:therapeutic use*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000172:deficiency*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000906:Antibodies; C534505:IMPAZA; D009569:Nitric Oxide; D004656:Enalapril; D019808:Losartan; D019331:NG-Nitroarginine Methyl Ester