Decreased expression of CIAPIN1 is correlated with poor prognosis in patients with esophageal squamous cell carcinoma.
BACKGROUND
CIAPIN1, a newly identified antiapoptotic molecule, is a downstream effector of the receptor tyrosine kinase-Ras signaling pathway in the mouse Ba/F3 pro-B cell line. Neither CIAPIN1 expression nor its clinical significance has been previously examined in esophageal squamous cell carcinoma (ESCC), and the present immunohistochemical analysis is the first study on CIAPIN1 distribution in ESCC.


OBJECTIVE
To investigate the relationships between the expression of CIAPIN1 and clinicopathological characteristics of ESCC, and evaluate the relationship between the expression of this gene and prognosis in ESCC patients.


METHODS
The expression of CIAPIN1 was investigated in 112 surgically resected specimens of ESCC by immunohistochemistry using a specific monoclonal antibody. The relations of CIAPIN1 expression with clinicopathological characteristics and the postoperative survival rate were statistically analyzed.


RESULTS
We found that the expression of CIAPIN1 was statistically correlated with the degree of differentiation, depth of invasion, and lymph node metastasis of ESCC. Consistently, the survival rates of patients with CIAPIN1-negative tumors tended to be statistically lower than those with CIAPIN1-positive tumors. However, no significant difference was observed between CIAPIN1 expression and the patient age, sex, tumor location, and distant metastasis. Furthermore, multivariate analysis was performed by using Cox's proportional hazards model, and the results showed that lymph node metastases and CIAPIN1 expression were two independent prognostic factors.


CONCLUSIONS
CIAPIN1 might play an important role in esophageal carcinogenesis, and it could be considered as a valuable prognostic indicator in ESCC. Finally, functional enhancement of CIAPIN1 might lead to a novel strategy for the treatment of SCC in the esophagus.
Zheng
Xiushan
X
State Key Laboratory of Cancer Biology, Xijing Hospital of Digestive Diseases, The Fourth Military Medical University, 710032, Xi'an, Shaanxi Province, People's Republic of China.
Zhao
Yunping
Y
Wang
Xin
X
Li
Yunming
Y
Wang
Ruwen
R
Jiang
Yaoguang
Y
Gong
Taiqian
T
Li
Mengbin
M
Sun
Li
L
Hong
Liu
L
Li
Xiaohua
X
Liang
Jie
J
Luo
Guanhong
G
Jin
Bin
B
Yang
Jianjun
J
Zhang
Hongwei
H
Fan
Daiming
D
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D002454:Cell Differentiation; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D007150:Immunohistochemistry; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D011379:Prognosis; D016016:Proportional Hazards Models
C489114:CIAPIN1 protein, human; D047908:Intracellular Signaling Peptides and Proteins
CA Cancer J Clin. 1999 Jan-Feb;49(1):8-31, 1
10200775
Surg Clin North Am. 2002 Aug;82(4):729-46
12472127
Anticancer Res. 2002 Nov-Dec;22(6C):3977-84
12553021
J Gastrointest Surg. 2010 Feb;14 Suppl 1:S75-80
19756878
Cancer. 2002 May 1;94(9):2511-6
12015777
Ann Surg. 2003 Aug;238(2):197-202
12894012
World J Gastroenterol. 2006 May 28;12(20):3237-42
16718845
Ann Surg. 2000 Aug;232(2):225-32
10903602
Cancer. 2000 Sep 1;89(5):946-54
10964323
Ann Thorac Cardiovasc Surg. 2003 Feb;9(1):6-13
12667124
Cancer Biol Ther. 2007 Oct;6(10):1539-45
18293492
Eur J Cancer. 2002 Apr;38(6):832-41
11937319
J Exp Med. 2004 Feb 16;199(4):581-92
14970183
Cancer Res. 1995 May 1;55(9):1856-62
7728753
Oncol Rep. 2003 Sep-Oct;10(5):1393-400
12883713
J Surg Oncol. 2005 Dec 1;92(3):257-61
16299785
Mol Biol (Mosk). 2008 Jan-Feb;42(1):102-9
18389626
J Histochem Cytochem. 2006 Dec;54(12):1437-44
16957168
Hematology. 2005;10 Suppl 1:73-5
16188641
Ann Oncol. 2005 Nov;16(11):1740-8
15980157
J Histochem Cytochem. 2006 Apr;54(4):417-26
16314443
Cancer Lett. 2006 Jan 8;231(1):94-101
16051426
Hybridoma (Larchmt). 2005 Jun;24(3):141-5
15943561
Cancer. 2002 Oct 1;95(7):1434-43
12237911