title: Laryngotracheal non-Hodgkin's lymphoma.
abstract: OBJECTIVE
  Malignant lymphomas of larynx and trachea are rare tumors and require special diagnostic and therapeutic attention. The authors present an unexpected case of nonHodgkin Lymphoma localized in the subglottic larynx and upper cervical trachea. The clinical presentation, diagnostic and therapeutic approach, evolution and prognosis are discussed.
  
  
  METHODS
  We report a case of 25-year-old male patient, with progressive dyspnea, presented in our ENT Department with severe airway obstruction caused by a large subglottic tumoral mass migrated in the glottic space during an accidental fall. An emergency tracheotomy was performed. The flexible endoscopy and CT-scan revealed a large mass arising from the subglottic larynx and anterior wall of upper cervical trachea with the obstruction of 2/3 of the laryngotracheal lumen.
  
  
  RESULTS
  After a complex assessment, the tumor was excised by external approach (median thyrotomy). The histopathologic exam of the surgical specimen showed malignant nonHodgkin lymphoma and the immunohistochemical profiles were evaluated in order to establish the therapeutic strategy including chemotherapy in the Department of Oncology.
  
  
  CONCLUSIONS
  Invasion of the subglottic larynx and trachea by lymphoma is an uncommon problem which can cause severe airway obstruction and requires multidisciplinary approach (ENT, pneumology, oncology/hematology). The clinicopathological features of this case have been described and compared with previously reported cases.
authors.affiliation: ENT Department, "Gr. T. Popa" University of Medicine and Pharmacy Iaşi, Romania. cobzeanu_dan@yahoo.com
authors.forename: M D
authors.initials: MD
authors.lastname: Cobzeanu
authors.forename: V
authors.initials: V
authors.lastname: Costinescu
authors.forename: C D
authors.initials: CD
authors.lastname: Rusu
authors.forename: S
authors.initials: S
authors.lastname: Mihailovici
authors.forename: M
authors.initials: M
authors.lastname: Grigoras
authors.forename: L
authors.initials: L
authors.lastname: Miron
authors.forename: D
authors.initials: D
authors.lastname: Paduraru
authors.forename: A
authors.initials: A
authors.lastname: Arama
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000209:etiology; D017024:Chemotherapy, Adjuvant; D003937:Diagnosis, Differential; D006801:Humans; D007822:Laryngeal Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000150:complications / Q000473:pathology* / Q000628:therapy; D008297:Male; D018714:Radiotherapy, Adjuvant; D014134:Tracheal Neoplasms / Q000150:complications / Q000473:pathology* / Q000628:therapy; D014140:Tracheotomy; D016896:Treatment Outcome