title: Comprehensive imaging of residual/ recurrent nasopharyngeal carcinoma using whole-body MRI at 3 T compared with FDG-PET-CT.
abstract: OBJECTIVE
  To prospectively compare the diagnostic potential of 3-T wholebody magnetic resonance imaging (WB-MRI) and integrated fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) (FDG-PET-CT), and their combined interpretation for the detection of residual/recurrent nasopharyngeal carcinoma (NPC).
  
  
  METHODS
  We enrolled 179 NPC patients at high risk of residual disease or with suspected recurrence. WB-MRI and FDG-PET-CT were obtained with an interval of <10 days.
  
  
  RESULTS
  Fifty-five (30.7%) patients were found to have residual/recurrent tumours. In a patient-based analysis, the sensitivity, specificity and diagnostic capability of WB-MRI were similar to those of FDG-PET-CT (90.9% vs. 87.3%, P=0.69; 91.1% vs. 90.3%, P>0.99; 0.929 vs. 0.924, P=0.83, respectively). Combined interpretation of WB-MRI with FDGPET-CT increased the sensitivity to 94.5%. A slight improvement in the diagnostic capability was obtained using a combined interpretation of WB-MRI and FDG-PET-CT over WB-MRI alone (0.952 vs. 0.929, P=0.22) and FDG-PET-CT alone (0.952 vs. 0.924, P=0.11).
  
  
  CONCLUSIONS
  Three-Tesla WB-MRI achieved a similar diagnostic capability to FDGPET-CT for the detection of residual/recurrent NPC. Both techniques have different advantages, and their combined interpretation can yield a slightly higher diagnostic capability. In clinical practice, 3-T WB-MRI can offer an accurate and comprehensive assessment of residual/recurrent NPC.
authors.affiliation: Molecular Imaging Center, Chang Gung University, Gueishan, Taiwan. shng6@ms25.hinet.net
authors.forename: Shu-Hang
authors.initials: SH
authors.lastname: Ng
authors.forename: Sheng-Chieh
authors.initials: SC
authors.lastname: Chan
authors.forename: Tzu-Chen
authors.initials: TC
authors.lastname: Yen
authors.forename: Chun-Ta
authors.initials: CT
authors.lastname: Liao
authors.forename: Joseph Tung-Chieh
authors.initials: JT
authors.lastname: Chang
authors.forename: Sheung-Fat
authors.initials: SF
authors.lastname: Ko
authors.forename: Hung-Ming
authors.initials: HM
authors.lastname: Wang
authors.forename: Chin-Yu
authors.initials: CY
authors.lastname: Lin
authors.forename: Kai-Ping
authors.initials: KP
authors.lastname: Chang
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis*; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D018365:Neoplasm, Residual / Q000175:diagnosis; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000379:methods*; D051598:Whole Body Imaging / Q000379:methods*; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18
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