Exercise changes regional vascular control by commissural NTS in spontaneously hypertensive rats.
Inhibition of the commissural nucleus of the solitary tract (commNTS) induces a fall in sympathetic nerve activity and blood pressure in spontaneously hypertensive rats (SHR), which suggests that this subnucleus of the NTS is a source of sympathoexcitation. Exercise training reduces sympathetic activity and arterial pressure. The purpose of the present study was to investigate whether the swimming exercise can modify the regional vascular responses evoked by inhibition of the commNTS neurons in SHR and normotensive Wistar-Kyoto (WKY) rats. Exercise consisted of swimming, 1 h/day, 5 days/wk for 6 wks, with a load of 2% of the body weight. The day after the last exercise session, the rats were anesthetized with intravenous alpha-chloralose, tracheostomized, and artificially ventilated. The femoral artery was cannulated for mean arterial pressure (MAP) and heart rate recordings, and Doppler flow probes were placed around the lower abdominal aorta and superior mesenteric artery. Microinjection of 50 mM GABA into the commNTS caused similar reductions in MAP in swimming and sedentary SHR (-25 +/- 6 and -30 +/- 5 mmHg, respectively), but hindlimb vascular conductance increased twofold in exercised vs. sedentary SHR (54 +/- 8 vs. 24 +/- 5%). GABA into the commNTS caused smaller reductions in MAP in swimming and sedentary WKY rats (-20 +/- 4 and -16 +/- 2 mmHg). Hindlimb conductance increased fourfold in exercised vs. sedentary WKY rats (75 +/- 2% vs. 19 +/- 3%). Therefore, our data suggest that the swimming exercise induced changes in commNTS neurons, as shown by a greater enhancement of hindlimb vasodilatation in WKY vs. SHR rats in response to GABAergic inhibition of these neurons.
Ogihara
Cristiana A
CA
Department of Physiology, Federal University of Sao Paulo, Sao Paulo, Brazil.
Schoorlemmer
Gerhardus H M
GH
Levada
Adriana C
AC
Pithon-Curi
Tania C
TC
Curi
Rui
R
Lopes
Oswaldo Ubriaco
OU
Colombari
Eduardo
E
Sato
Monica A
MA
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology*; D001808:Blood Vessels / Q000187:drug effects; D001835:Body Weight; D002698:Chloralose / Q000494:pharmacology; D004734:Energy Metabolism; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006614:Hindlimb / Q000187:drug effects; D008297:Male; D008845:Microinjections; D010805:Physical Conditioning, Animal; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017552:Solitary Nucleus / Q000187:drug effects / Q000503:physiopathology*; D013116:Spinal Cord / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D002698:Chloralose; D005680:gamma-Aminobutyric Acid