title: Form and function in cell motility: from fibroblasts to keratocytes.
abstract: It is plain enough that a horse is made for running, but similar statements about motile cells are not so obvious. Here the basis for structure-function relations in cell motility is explored by application of a new computational technique that allows realistic three-dimensional simulations of cells migrating on flat substrata. With this approach, some cyber cells spontaneously display the classic irregular protrusion cycles and handmirror morphology of a crawling fibroblast, and others the steady gliding motility and crescent morphology of a fish keratocyte. The keratocyte motif is caused by optimal recycling of the cytoskeleton from the back to the front so that more of the periphery can be devoted to protrusion. These calculations are a step toward bridging the gap between the integrated mechanics and biophysics of whole cells and the microscopic molecular biology of cytoskeletal components.
authors.affiliation: Biomedical Engineering Department, Boston University, Boston, Massachusetts, USA. herantm@bu.edu
authors.forename: Marc
authors.initials: M
authors.lastname: Herant
authors.forename: Micah
authors.initials: M
authors.lastname: Dembo
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002465:Cell Movement; D048430:Cell Shape; D003599:Cytoskeleton / Q000378:metabolism; D005347:Fibroblasts / Q000166:cytology*; D005399:Fishes; D008954:Models, Biological
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