Von Willebrand factor expression in endometrial endothelial cells in women with menorrhagia.
This prospective study assessed von Willebrand factor (VWF) expression in the endometrium using immunohistochemical staining in women with menorrhagia with or without von Willebrand disease (VWD) compared with a control group of women with normal menstrual loss. Endometrial VWF expression is significantly lower in women with VWD, which may play a local underlying role in pathogenesis of menorrhagia in these women.
Agarwal
Umber
U
Department of Obstetrics and Gynaecology, Royal Free Hospital, Hampstead, London, United Kingdom.
El Sheikh
Soha
S
Kulkarni
Ashwini
A
Baff
Donna
D
Kadir
Rezan A
RA
D000328:Adult; D001706:Biopsy; D016022:Case-Control Studies; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D042783:Endothelial Cells / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008595:Menorrhagia / Q000378:metabolism* / Q000473:pathology; D008597:Menstrual Cycle / Q000378:metabolism; D008875:Middle Aged; D014841:von Willebrand Factor / Q000378:metabolism*
D014841:von Willebrand Factor