title: Differential olivo-cerebellar cortical control of rebound activity in the cerebellar nuclei.
abstract: The output of the cerebellar cortex is controlled by two main inputs, (i.e., the climbing fiber and mossy fiber-parallel fiber pathway) and activations of these inputs elicit characteristic effects in its Purkinje cells: that is, the so-called complex spikes and simple spikes. Target neurons of the Purkinje cells in the cerebellar nuclei show rebound firing, which has been implicated in the processing and storage of motor coordination signals. Yet, it is not known to what extent these rebound phenomena depend on different modes of Purkinje cell activation. Using extracellular as well as patch-clamp recordings, we show here in both anesthetized and awake rodents that simple and complex spike-like train stimuli to the cerebellar cortex, as well as direct activation of the inferior olive, all result in rebound increases of the firing frequencies of cerebellar nuclei neurons for up to 250 ms, whereas single-pulse stimuli to the cerebellar cortex predominantly elicit well-timed spiking activity without changing the firing frequency of cerebellar nuclei neurons. We conclude that the rebound phenomenon offers a rich and powerful mechanism for cerebellar nuclei neurons, which should allow them to differentially process the climbing fiber and mossy fiber inputs in a physiologically operating cerebellum.
authors.affiliation: Department of Neuroscience, Erasmus Medical Center, 3000 CA Rotterdam, The Netherlands.
authors.forename: Freek E
authors.initials: FE
authors.lastname: Hoebeek
authors.forename: Laurens
authors.initials: L
authors.lastname: Witter
authors.forename: Tom J H
authors.initials: TJ
authors.lastname: Ruigrok
authors.forename: Chris I
authors.initials: CI
authors.lastname: De Zeeuw
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D002529:Cerebellar Nuclei / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar
references.citation: Trends Neurosci. 1998 Sep;21(9):391-400
references.pmid: 9735947
references.citation: J Neurophysiol. 2007 Jan;97(1):901-11
references.pmid: 17093116
references.citation: J Neurophysiol. 1999 Oct;82(4):1697-709
references.pmid: 10515960
references.citation: J Neurophysiol. 2005 Aug;94(2):1236-51
references.pmid: 16061491
references.citation: Brain Res. 1971 Aug 7;31(1):215-9
references.pmid: 4328277
references.citation: J Physiol. 2008 May 15;586(10):2523-38
references.pmid: 18372310
references.citation: Physiol Rev. 1974 Apr;54(2):358-417
references.pmid: 4362162
references.citation: Neuron. 2006 Jul 6;51(1):113-23
references.pmid: 16815336
references.citation: J Neurophysiol. 2001 Apr;85(4):1686-96
references.pmid: 11287491
references.citation: J Neurosci. 2009 Aug 5;29(31):9826-38
references.pmid: 19657035
references.citation: J Neurosci. 1992 Mar;12(3):1063-76
references.pmid: 1312132
references.citation: J Neurosci. 2000 Dec 15;20(24):9004-16
references.pmid: 11124976
references.citation: Nat Neurosci. 2006 Apr;9(4):459-61; author reply 461
references.pmid: 16568098
references.citation: Neuroscience. 2008 Oct 15;156(3):537-49
references.pmid: 18755250
references.citation: Neuron. 2005 Aug 4;47(3):339-52
references.pmid: 16055059
references.citation: Eur J Neurosci. 1995 Nov 1;7(11):2322-33
references.pmid: 8563981
references.citation: Ann N Y Acad Sci. 1996 Jun 19;781:607-10
references.pmid: 8694453
references.citation: Eur J Neurosci. 1989 Jan;1(6):587-602
references.pmid: 12106117
references.citation: J Neurosci. 2004 Jan 14;24(2):434-41
references.pmid: 14724241
references.citation: J Neurophysiol. 2008 Oct;100(4):2328-47
references.pmid: 17671105
references.citation: J Physiol. 1993 Oct;470:243-71
references.pmid: 8308729
references.citation: Neuroscience. 2009 Jan 23;158(2):635-41
references.pmid: 18983899
references.citation: J Neurophysiol. 1994 Jan;71(1):420-8
references.pmid: 8158239
references.citation: Curr Biol. 2000 Jul 13;10(14):R522-5
references.pmid: 10898992
references.citation: Nat Neurosci. 2009 Aug;12(8):1042-9
references.pmid: 19578381
references.citation: Prog Brain Res. 1997;114:167-92
references.pmid: 9193144
references.citation: J Physiol. 1986 Mar;372:129-47
references.pmid: 3723407
references.citation: Prog Brain Res. 2000;124:141-72
references.pmid: 10943123
references.citation: J Neurosci. 2005 Jan 12;25(2):464-72
references.pmid: 15647490
references.citation: Exp Brain Res. 1966;1(1):17-39
references.pmid: 5910940
references.citation: J Comp Neurol. 2000 Oct 16;426(2):209-28
references.pmid: 10982464
references.citation: Neuron. 2008 May 22;58(4):599-612
references.pmid: 18498740
references.citation: Neuron. 2005 Mar 24;45(6):953-65
references.pmid: 15797555
references.citation: J Neurophysiol. 1998 Jan;79(1):240-52
references.pmid: 9425195
references.citation: Channels (Austin). 2009 May-Jun;3(3):149-55
references.pmid: 19535914
references.citation: J Neurophysiol. 2008 Feb;99(2):704-17
references.pmid: 18077662
references.citation: J Neurophysiol. 1993 Apr;69(4):1082-90
references.pmid: 8492150
references.citation: J Neurophysiol. 2008 Nov;100(5):2684-701
references.pmid: 18768644
references.citation: Neuroscience. 1994 Dec;63(3):711-24
references.pmid: 7898672
references.citation: Trends Neurosci. 2009 Mar;32(3):170-7
references.pmid: 19178955
references.citation: Neural Comput. 2002 Nov;14(11):2597-626
references.pmid: 12433292
references.citation: J Neurophysiol. 1968 Sep;31(5):785-97
references.pmid: 4974877
references.citation: J Neurophysiol. 2007 Sep;98(3):1697-705
references.pmid: 17615140
references.citation: Neuron. 2009 May 14;62(3):388-99
references.pmid: 19447094
references.citation: J Comp Neurol. 1989 Oct 1;288(1):1-18
references.pmid: 2794133
references.citation: J Comp Neurol. 1981 Apr 1;197(2):217-36
references.pmid: 7276233
references.citation: Brain Res. 1977 Feb 18;122(2):197-214
references.pmid: 837228
references.citation: Anesthesiology. 1994 Jul;81(1):104-16
references.pmid: 8042778
references.citation: Brain Res. 1983 Sep 12;274(2):249-59
references.pmid: 6626953
references.citation: J Neurophysiol. 1992 Dec;68(6):2051-62
references.pmid: 1491256
references.citation: Exp Brain Res. 1970;10(2):121-39
references.pmid: 4314010
references.citation: Neuroscience. 1992 Aug;49(4):903-11
references.pmid: 1359457
references.citation: J Neurosci. 2008 Oct 15;28(42):10549-60
references.pmid: 18923031
references.citation: J Physiol. 1988 Oct;404:241-58
references.pmid: 2855348
references.citation: J Neurosci. 2005 Jan 12;25(2):454-63
references.pmid: 15647489
references.citation: J Neurosci. 2000 Apr 15;20(8):3006-16
references.pmid: 10751453
references.citation: Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15911-6
references.pmid: 17895389
references.citation: Eur J Neurosci. 1995 Apr 1;7(4):679-93
references.pmid: 7542527
references.citation: J Physiol. 2006 May 15;573(Pt 1):277-9; author reply 281-2
references.pmid: 16702352
references.citation: J Neurosci. 2008 May 14;28(20):5383-93
references.pmid: 18480294
references.citation: Nat Neurosci. 2008 Nov;11(11):1256-8
references.pmid: 18820695
references.citation: J Comp Neurol. 2005 Nov 14;492(2):193-213
references.pmid: 16196034
references.citation: Pflugers Arch. 2002 Jul;444(4):491-8
references.pmid: 12136268
references.citation: J Comput Neurosci. 2008 Apr;24(2):137-56
references.pmid: 17616795
references.citation: Proc Natl Acad Sci U S A. 2006 Apr 4;103(14):5555-60
references.pmid: 16567615
references.citation: Neuroscience. 2000;101(4):815-50
references.pmid: 11113332
references.citation: J Neurophysiol. 1997 Apr;77(4):1747-58
references.pmid: 9114233