title: Human leukocyte antigen class I and II alleles in non-Hodgkin lymphoma etiology.
abstract: Genome-wide association and candidate gene studies implicate different genetic variants within the 6p21 chromosomal region with different non-Hodgkin lymphoma (NHL) subtypes. Complementing these efforts, we conducted human leukocyte antigen (HLA) class I and class II genotyping among 610 NHL cases and 555 controls of non-Hispanic white descent from a US multicenter study. Allele-disease associations were assessed by logistic regression for NHL and its subtypes. Statistically significant associations between HLA and NHL subtypes include HLA-DRB1*0101 for follicular lymphoma (odds ratio [OR] = 2.14, P < .001), HLA-DRB1*0401 for diffuse large B-cell lymphoma (DLBCL; OR = 0.45, P = .006), and HLA-DRB1*13 and follicular lymphoma (OR = 0.48, P = .008). We further observed significant heterozygote advantage for HLA class I alleles and NHL, and particularly DLBCL (P trend = .01 for elevated risk with increasing number of homozygous alleles). Our results support a role for HLA in the etiology of NHL and its subtypes.
authors.affiliation: Division of Cancer Etiology, Department of Population Sciences, City of Hope, Duarte, CA 91010, USA. sowang@coh.org
authors.forename: Sophia S
authors.initials: SS
authors.lastname: Wang
authors.forename: Amr M
authors.initials: AM
authors.lastname: Abdou
authors.forename: Lindsay M
authors.initials: LM
authors.lastname: Morton
authors.forename: Rasmi
authors.initials: R
authors.lastname: Thomas
authors.forename: James R
authors.initials: JR
authors.lastname: Cerhan
authors.forename: Xiaojiang
authors.initials: X
authors.lastname: Gao
authors.forename: Wendy
authors.initials: W
authors.lastname: Cozen
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
authors.forename: Scott
authors.initials: S
authors.lastname: Davis
authors.forename: Richard K
authors.initials: RK
authors.lastname: Severson
authors.forename: Leslie
authors.initials: L
authors.lastname: Bernstein
authors.forename: Patricia
authors.initials: P
authors.lastname: Hartge
authors.forename: Mary
authors.initials: M
authors.lastname: Carrington
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D005260:Female; D055106:Genome-Wide Association Study; D006579:Heterozygote; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II
references.citation: Cancer Res. 2006 Oct 1;66(19):9771-80
references.pmid: 17018637
references.citation: Hepatology. 1998 Jan;27(1):240-4
references.pmid: 9425943
references.citation: J Gastroenterol Hepatol. 2008 Nov;23(11):1716-21
references.pmid: 18761557
references.citation: J Viral Hepat. 2007 Dec;14(12):841-8
references.pmid: 18070287
references.citation: Leukemia. 2010 May;24(5):1055-8
references.pmid: 20147981
references.citation: J Neuroimmunol. 2002 Jan;122(1-2):140-5
references.pmid: 11777553
references.citation: Nat Genet. 2009 Aug;41(8):873-5
references.pmid: 19620980
references.citation: Nat Genet. 2006 Oct;38(10):1166-72
references.pmid: 16998491
references.citation: J Immunol. 2004 Oct 1;173(7):4273-6
references.pmid: 15383555
references.citation: Am J Epidemiol. 2010 Feb 1;171(3):267-76
references.pmid: 20047977
references.citation: J Natl Cancer Inst Monogr. 2003;(31):35-40
references.pmid: 12807943
references.citation: J Hepatol. 1997 Mar;26(3):503-7
references.pmid: 9075656
references.citation: Nature. 1975 Jul 3;256(5512):50-2
references.pmid: 1079575
references.citation: J Hepatol. 1997 Aug;27(2):259-64
references.pmid: 9288598
references.citation: Science. 1999 Mar 12;283(5408):1748-52
references.pmid: 10073943
references.citation: Arthritis Rheum. 2010 May;62(5):1236-45
references.pmid: 20131291
references.citation: Lancet Oncol. 2006 Jan;7(1):27-38
references.pmid: 16389181