title: Effects of topical application of 10,000 IU heparin on patients with perineal dermatitis and second-degree burns treated in a public pediatric hospital.
abstract: BACKGROUND
  High-molecular-weight sodium heparin (10,000 IU) has been developed based on studies conducted on burn patients; it has anti-inflammatory, antigenic and anticoagulant properties.
  
  
  OBJECTIVE
  The aim of this paper was to evaluate the effects of topical application of sodium heparin spray on two immunosuppressed patients (a child and a young person) with perineal dermatitis and an immunosuppressed child with second-degree burns.
  
  
  METHODS
  This is a report of three clinical cases treated in a pediatric hospital. Sodium heparin spray (10,000 IU) was applied at a dose of 4200 IU per percentage of body surface area affected over the hyperemic region. Heparin spray treatment was discontinued after crust formation and wound reepithelialization; essential fatty acid was applied until spontaneous separation of the crust or total wound reepithelialization.
  
  
  RESULTS
  Heparin spray had analgesic, angiogenic and anti-inflammatory effects, and did not require secondary wound closure. Pain control was of fundamental importance to the patients; in the three cases, improvement in analgesia was achieved within 24 h of treatment.
  
  
  CONCLUSIONS
  The topical application of heparin spray in patients with perineal dermatitis or superficial second-degree burns demonstrated good tolerability, resulted in good aesthetic outcomes, and reduced pain.
authors.affiliation: Graduate Program, Federal University of São Paulo (UNIFESP), Rua Napoleão de Barros 715, 4o andar, Vila Clementino, CEP 04024-002 São Paulo, Brazil. julieta.chacon@uol.com.br
authors.forename: Julieta Maria
authors.initials: JM
authors.lastname: Ferreira Chacon
authors.forename: Maria Lydia
authors.initials: ML
authors.lastname: Mello de Andrea
authors.forename: Leila
authors.initials: L
authors.lastname: Blanes
authors.forename: Lydia Masako
authors.initials: LM
authors.lastname: Ferreira
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000336:Aerosols; D001938:Brazil; D002056:Burns / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D002675:Child, Preschool; D003872:Dermatitis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D006493:Heparin / Q000008:administration & dosage* / Q000276:immunology / Q000494:pharmacology; D006776:Hospitals, Pediatric; D006779:Hospitals, Public; D006801:Humans; D016867:Immunocompromised Host; D007223:Infant; D008297:Male; D010146:Pain / Q000209:etiology / Q000517:prevention & control; D010502:Perineum; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000336:Aerosols; D006493:Heparin