title: Pulmonary non-Hodgkin's lymphoma developed during long-term methotrexate therapy for rheumatoid arthritis.
abstract: Methotrexate is effective in treating rheumatoid arthritis (RA). Some reports have discussed the possible association between methotrexate and lymphoma. Here, we report a case of pulmonary non-Hodgkin's lymphoma (NHL) developed after 11 years' methotrexate therapy for RA. Biopsy of the pulmonary mass demonstrated a diffuse large B-cell lymphoma. After withdrawal of methotrexate without any other intervention for 4 weeks, a significant reduction in the size of the lymphoma was observed. The causative relationship between methotrexate and pulmonary lymphoma is suggested by the persistent remission after stopping methotrexate therapy.
authors.affiliation: Department of Respiratory Medicine, The Second Affiliated Hospital of Zhejiang University Medical School, Respiratory Institute of Zhejiang University, 88 Jiefang Road, 310009 Hangzhou, Zhejiang Province, People's Republic of China. w_huiying@yahoo.com
authors.forename: Huiying
authors.initials: H
authors.lastname: Wang
authors.forename: Dandan
authors.initials: D
authors.lastname: Wu
authors.forename: Hua
authors.initials: H
authors.lastname: Xiang
authors.forename: Aifeng
authors.initials: A
authors.lastname: Chen
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced* / Q000473:pathology; D008727:Methotrexate / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D008727:Methotrexate
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