title: Division of labor during trunk neural crest development.
abstract: Neural crest cells, the migratory precursors of numerous cell types including the vertebrate peripheral nervous system, arise in the dorsal neural tube and follow prescribed routes into the embryonic periphery. While the timing and location of neural crest migratory pathways has been well documented in the trunk, a comprehensive collection of signals that guides neural crest migration along these paths has only recently been established. In this review, we outline the molecular cascade of events during trunk neural crest development. After describing the sequential routes taken by trunk neural crest cells, we consider the guidance cues that pattern these neural crest trajectories. We pay particular attention to segmental neural crest development and the steps and signals that generate a metameric peripheral nervous system, attempting to reconcile conflicting observations in chick and mouse. Finally, we compare cranial and trunk neural crest development in order to highlight common themes.
authors.affiliation: Department of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, MN 55455, USA. gammi001@umn.edu
authors.forename: Laura S
authors.initials: LS
authors.lastname: Gammill
authors.forename: Julaine
authors.initials: J
authors.lastname: Roffers-Agarwal
mesh_terms: D000818:Animals; D051379:Mice; D009432:Neural Crest / Q000196:embryology* / Q000502:physiology*; D055495:Neurogenesis; D009474:Neurons / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014714:Vertebrates
references.citation: J Cell Biol. 2007 Sep 24;178(7):1237-49
references.pmid: 17875744
references.citation: Cell. 2001 Jan 12;104(1):57-69
references.pmid: 11163240
references.citation: Dev Biol. 1998 Dec 15;204(2):327-44
references.pmid: 9882474
references.citation: Nature. 1984 Aug 30-Sep 5;310(5980):786-9
references.pmid: 6472458
references.citation: Development. 2009 Jun;136(11):1785-9
references.pmid: 19386662
references.citation: Dev Dyn. 1999 Apr;214(4):312-22
references.pmid: 10213387
references.citation: Dev Biol. 2010 Mar 1;339(1):114-25
references.pmid: 20036652
references.citation: Development. 1993 Jun;118(2):363-76
references.pmid: 7693414
references.citation: Dev Dyn. 2004 Jun;230(2):299-308
references.pmid: 15162508
references.citation: Genes Dev. 2008 Feb 15;22(4):416-29
references.pmid: 18281458
references.citation: Nature. 2007 Aug 23;448(7156):901-7
references.pmid: 17713529
references.citation: Philos Trans R Soc Lond B Biol Sci. 2000 Jul 29;355(1399):953-64
references.pmid: 11128989
references.citation: Gene Expr. 2002;10(5-6):295-305
references.pmid: 12450221
references.citation: Dev Biol. 1991 Sep;147(1):187-206
references.pmid: 1908800
references.citation: J Neurosci. 1986 Dec;6(12):3465-73
references.pmid: 3794784
references.citation: Development. 2008 Dec;135(24):4113-22
references.pmid: 19004859
references.citation: Dev Biol. 2007 Apr 1;304(1):182-93
references.pmid: 17223098
references.citation: Dev Dyn. 2007 Jan;236(1):1-19
references.pmid: 16894594
references.citation: J Cell Biol. 1998 Dec 14;143(6):1725-34
references.pmid: 9852163
references.citation: Curr Opin Genet Dev. 2003 Oct;13(5):529-36
references.pmid: 14550420
references.citation: Development. 1994 Jan;120(1):103-14
references.pmid: 8119119
references.citation: Adv Exp Med Biol. 2007;600:73-89
references.pmid: 17607948
references.citation: Dev Biol. 1994 Jun;163(2):389-406
references.pmid: 7515361
references.citation: PLoS Biol. 2006 Oct;4(10):e315
references.pmid: 16968134
references.citation: Development. 1989 May;106(1):85-93
references.pmid: 2627888
references.citation: Mech Dev. 2001 Jul;105(1-2):37-45
references.pmid: 11429280
references.citation: Genes Dev. 2004 Mar 1;18(5):572-83
references.pmid: 15037550
references.citation: Development. 1994 Jul;120(7):1709-18
references.pmid: 7523054
references.citation: Development. 2000 Jun;127(11):2259-67
references.pmid: 10804169
references.citation: Dev Biol. 2000 Mar 1;219(1):79-97
references.pmid: 10677257
references.citation: Dev Biol. 1985 Sep;111(1):138-57
references.pmid: 4029505
references.citation: Nat Rev Mol Cell Biol. 2008 Jul;9(7):557-68
references.pmid: 18523435
references.citation: Dev Biol. 1982 Oct;93(2):324-43
references.pmid: 7141101
references.citation: Dev Biol. 1987 Apr;120(2):329-47
references.pmid: 3549390
references.citation: Development. 1991 Jan;111(1):15-22
references.pmid: 1707785
references.citation: Development. 1999 May;126(10):2181-9
references.pmid: 10207143
references.citation: J Cell Biol. 1987 May;104(5):1361-74
references.pmid: 3553211
references.citation: Development. 1987 Nov;101(3):461-78
references.pmid: 3332259
references.citation: Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6594-9
references.pmid: 8692862
references.citation: Dev Neurobiol. 2007 Jan;67(1):47-56
references.pmid: 17443771
references.citation: Mol Cell Neurosci. 2005 May;29(1):40-55
references.pmid: 15866045
references.citation: Genes Dev. 1998 Jun 15;12(12):1825-36
references.pmid: 9637684
references.citation: Dev Biol. 1992 May;151(1):251-72
references.pmid: 1577191
references.citation: Development. 1991 May;112(1):327-34
references.pmid: 1769337
references.citation: Development. 2002 Aug;129(15):3621-32
references.pmid: 12117812
references.citation: J Embryol Exp Morphol. 1986 Feb;91:209-26
references.pmid: 3519826
references.citation: Neuron. 2002 Jul 18;35(2):267-82
references.pmid: 12160745
references.citation: Development. 2004 Dec;131(24):6141-51
references.pmid: 15548586
references.citation: Neuron. 1997 Mar;18(3):383-96
references.pmid: 9115733
references.citation: Development. 1995 Aug;121(8):2303-12
references.pmid: 7671797
references.citation: Dev Biol. 2001 May 1;233(1):38-55
references.pmid: 11319856
references.citation: J Cell Biol. 1997 Jun 30;137(7):1663-81
references.pmid: 9199179
references.citation: Curr Biol. 1997 Aug 1;7(8):571-80
references.pmid: 9259560
references.citation: Genes Dev. 1998 Oct 1;12(19):3096-109
references.pmid: 9765210
references.citation: Dev Biol. 2001 Apr 15;232(2):471-83
references.pmid: 11401406
references.citation: Development. 2004 Nov;131(21):5327-39
references.pmid: 15456730
references.citation: Development. 2010 Feb;137(4):585-95
references.pmid: 20110324
references.citation: Dev Biol. 1987 Mar;120(1):38-49
references.pmid: 3817299
references.citation: J Embryol Exp Morphol. 1979 Dec;54:75-98
references.pmid: 528873
references.citation: Science. 1993 Jan 29;259(5095):692-5
references.pmid: 8430321
references.citation: J Biol Chem. 2000 Jun 16;275(24):18040-5
references.pmid: 10748121
references.citation: Development. 1995 Nov;121(11):3733-43
references.pmid: 8582285
references.citation: Cytokine. 2003 Jan 7;21(1):48-9
references.pmid: 12668160
references.citation: Proc Natl Acad Sci U S A. 2009 Apr 14;106(15):6164-9
references.pmid: 19325129
references.citation: Development. 1989 Aug;106(4):809-16
references.pmid: 2562671
references.citation: Nat Neurosci. 2007 Oct;10(10):1287-93
references.pmid: 17828258
references.citation: Dev Biol. 1998 Aug 15;200(2):234-46
references.pmid: 9705230
references.citation: Nat Rev Neurosci. 2007 Feb;8(2):114-27
references.pmid: 17237804
references.citation: Neuron. 2005 Sep 1;47(5):667-79
references.pmid: 16129397
references.citation: Dev Biol. 1986 May;115(1):44-55
references.pmid: 3516760
references.citation: Dev Dyn. 1995 May;203(1):106-18
references.pmid: 7544170
references.citation: Development. 2000 Jun;127(11):2251-8
references.pmid: 10804168
references.citation: Dev Dyn. 2005 Apr;232(4):939-49
references.pmid: 15729704
references.citation: Cell. 1998 May 29;93(5):741-53
references.pmid: 9630219
references.citation: Nat Rev Neurosci. 2007 Jun;8(6):466-79
references.pmid: 17514199
references.citation: Dev Biol. 1989 Mar;132(1):14-25
references.pmid: 2465193
references.citation: Development. 2009 Jun;136(11):1801-12
references.pmid: 19429784
references.citation: Neuron. 1989 Dec;3(6):755-66
references.pmid: 2484346
references.citation: J Cell Physiol. 2001 Sep;188(3):394-402
references.pmid: 11473366
references.citation: Development. 1991 Aug;112(4):913-20
references.pmid: 1935700
references.citation: Dev Dyn. 2001 Sep;222(1):115-9
references.pmid: 11507773
references.citation: J Biol Chem. 2006 Apr 28;281(17):12123-31
references.pmid: 16510447
references.citation: Dev Biol. 1991 Feb;143(2):213-7
references.pmid: 1991548
references.citation: Dev Cell. 2003 Jul;5(1):45-57
references.pmid: 12852851
references.citation: Semin Cell Dev Biol. 2007 Feb;18(1):101-10
references.pmid: 17224285
references.citation: Genes Dev. 1999 Feb 1;13(3):295-306
references.pmid: 9990854
references.citation: EMBO J. 1996 Nov 15;15(22):6035-49
references.pmid: 8947026
references.citation: Int J Dev Biol. 2008;52(1):87-92
references.pmid: 18033676
references.citation: J Neurosci. 2005 Apr 20;25(16):3995-4003
references.pmid: 15843601
references.citation: Dev Biol. 2005 Jun 15;282(2):411-21
references.pmid: 15950606
references.citation: Development. 2009 Jun;136(11):1879-88
references.pmid: 19403658
references.citation: Dev Biol. 1998 Oct 1;202(1):29-42
references.pmid: 9758701
references.citation: Nat Rev Mol Cell Biol. 2005 Jun;6(6):462-75
references.pmid: 15928710
references.citation: J Embryol Exp Morphol. 1985 Dec;90:437-55
references.pmid: 3834038
references.citation: Nature. 1988 Sep 8;335(6186):161-4
references.pmid: 2457813
references.citation: Development. 1990 Apr;108(4):605-12
references.pmid: 2387238
references.citation: J Neurosci. 2010 Sep 29;30(39):13078-88
references.pmid: 20881125
references.citation: Development. 2006 Jan;133(1):99-106
references.pmid: 16319111
references.citation: Development. 2002 Feb;129(3):671-80
references.pmid: 11830568
references.citation: Development. 2000 Mar;127(6):1161-72
references.pmid: 10683170
references.citation: Mech Dev. 2000 Jul;95(1-2):3-21
references.pmid: 10906446
references.citation: Neuron. 1999 Mar;22(3):475-88
references.pmid: 10197528
references.citation: Dev Biol. 2005 Apr 15;280(2):373-85
references.pmid: 15882579
references.citation: Dev Biol. 1987 May;121(1):220-36
references.pmid: 3552788
references.citation: Development. 1995 Mar;121(3):915-24
references.pmid: 7720593
references.citation: Development. 2000 Jul;127(13):2823-42
references.pmid: 10851128
references.citation: Development. 2004 Dec;131(24):6153-62
references.pmid: 15548576
references.citation: Development. 1991 Aug;112(4):1031-9
references.pmid: 1718677
references.citation: Int J Biochem Cell Biol. 2004 Jun;36(6):1090-101
references.pmid: 15094124
references.citation: Dev Dyn. 2001 Oct;222(2):127-40
references.pmid: 11668592
references.citation: Neuron. 2005 Dec 22;48(6):949-64
references.pmid: 16364899
references.citation: Genes Dev. 1992 Oct;6(10):1821-31
references.pmid: 1383086
references.citation: Nature. 1999 Jul 1;400(6739):77-81
references.pmid: 10403252
references.citation: Dev Dyn. 1999 Jan;214(1):55-65
references.pmid: 9915576
references.citation: Neuron. 1990 Jan;4(1):11-20
references.pmid: 2155629
references.citation: Development. 1995 Mar;121(3):731-42
references.pmid: 7536655
references.citation: J Cell Biol. 1985 Aug;101(2):610-7
references.pmid: 4019585
references.citation: Blood. 2002 Aug 15;100(4):1326-33
references.pmid: 12149214
references.citation: Curr Top Dev Biol. 1991;25:133-53
references.pmid: 1660392
references.citation: Development. 2008 May;135(9):1605-13
references.pmid: 18356247
references.citation: Development. 1997 Nov;124(21):4309-19
references.pmid: 9334279
references.citation: Development. 2005 Jan;132(2):235-45
references.pmid: 15590743
references.citation: Development. 1999 Nov;126(21):4749-62
references.pmid: 10518492
references.citation: Dev Biol. 2007 Jan 1;301(1):227-39
references.pmid: 16959234
references.citation: Dev Biol. 1996 Nov 25;180(1):41-53
references.pmid: 8948573
references.citation: Mech Dev. 2004 Sep;121(9):1055-68
references.pmid: 15296971
references.citation: Auton Neurosci. 2009 Nov 17;151(1):3-9
references.pmid: 19783486
references.citation: Development. 2006 Sep;133(18):3629-39
references.pmid: 16914489
references.citation: Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3024-9
references.pmid: 9501209
references.citation: Development. 2006 Dec;133(24):4839-47
references.pmid: 17108003
references.citation: Cell Tissue Res. 1980;211(2):269-91
references.pmid: 6998561
references.citation: Cell. 1998 Mar 20;92(6):735-45
references.pmid: 9529250