[Abortifacient properties and effect of an misoprostol analogue 11-deoxy-misoprostol on the contractile activity of the rat uterus].
Ethyl ether of 11-deoxy-16-hydroxy-16-metylprostaglandin E1 (11-deoxymisoprostol) increases the contractile activity of uterine horn segments isolated from nonpregnant rats and produces abortive effect when given in a period of time within 1 - 16 days of pregnancy. The drug action is related to a decrease of the progesterone level in ovarian incubates of pregnant rats.
Gabdrakhmanova
S F
SF
Sapozhnikova
T A
TA
Baschenko
N Zh
NZh
Zarudyĭ
F S
FS
Ivanova
N A
NA
D000019:Abortifacient Agents / Q000494:pharmacology*; D000028:Abortion, Induced; D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D016595:Misoprostol / Q000031:analogs & derivatives* / Q000494:pharmacology; D010053:Ovary / Q000187:drug effects / Q000378:metabolism; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects*
C475855:2-demethoxycarbonyl-2-ethoxycarbonyl-11-deoxymisoprostol; D000019:Abortifacient Agents; D016595:Misoprostol; D011374:Progesterone