Effect of a six-hour marathon ultra-race on the levels of IL-6, LIF, and SCF.
The effects of 6-h marathon ultra-race (long aerobic work below the lactate threshold level) on the levels of IL-6, leukemia inhibiting factor (LIF), and stem cell growth factor (SCF) were studied. The athletes participating in the study had different endurance levels evaluated by the distance covered over 6 h. The level of IL-6 sharply increased after exercise. The degree of IL-6 increase correlated with the length of the distance covered (r=0.83, p=0.042). The concentration of LIF after exercise inversely correlated with the distance covered (r=-0.75), but this correlation was statistically insignificant. The IL-6/LIF proportion exhibited the highest correlation with the result in the marathon ultra-race. This parameter most fully characterized athlete endurance (r=0.92, p=0.009). Hence, the relationship of LIF with physical endurance was demonstrated. Involvement of LIF in antibody production processes can be responsible for it.
Donnikov
A E
AE
Institute of Physical Culture and Athletics, Moscow, Russia. donnikov@dna-technology.ru
Shkurnikov
M Yu
MY
Akimov
E B
EB
Grebenyuk
E S
ES
Khaustova
S A
SA
Shahmatova
E M
EM
Tonevitsky
A G
AG
D056352:Athletes; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D053605:Leukemia Inhibitory Factor / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood; D010807:Physical Endurance / Q000276:immunology / Q000502:physiology; D012420:Running / Q000502:physiology*; D019089:Stem Cell Factor / Q000097:blood*
D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; D019089:Stem Cell Factor; D008315:Malondialdehyde