title: Fascin, cortactin and survivin expression of melanocytic neoplasms and association with clinicopathological parameters and anatomic locations in Chinese people.
abstract: Distinct genetic aberrations between melanomas in different anatomical locations have been confirmed in recent years. However, the associations between immunohistochemical expression, tumor sites, and clinical parameters are not clear. We examined the correlation of protein expression of fascin, cortactin and survivin with clinicopathological parameters and lesion locations in patients with cutaneous melanoma. We collected 170 melanocytic lesions, including 106 cutaneous malignant melanoma (MM) from acral (AM) and non-acral (NAM) sites, 24 dysplastic nevi (DN), and 40 common melanocytic nevi (CMN). Tissue micro arrays were constructed and immunohistochemical expression for cortactin, fascin, and survivin was assessed with correlation with clinical parameters. Cytoplasmic immunostaining for fascin was found to be significantly higher in CMN than DN, and survivin staining was significantly higher in DN than MM. Positive nuclear immunoreactivity for survivin was seen in a large subset of melanomas but much less frequently in CMN and DN. In addition, nuclear survivin immunoreactivity was significantly more common in NAM than in AM. Nuclear survivin staining in patients with NAM was significantly correlated with poor survival. The significantly different expression of immunoreactivities (nuclear survivin) between AM and NAM and the different mortality risks of melanomas on acral versus non-acral sites might change site-specific therapeutic concepts in melanoma.
authors.affiliation: Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, No. 325, Sec. 2, Cheng-Kung Road, Neihu 114, Taipei, Taiwan, Republic of China.
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Gao
authors.forename: Cheng-Ping
authors.initials: CP
authors.lastname: Yu
authors.forename: Herng-Sheng
authors.initials: HS
authors.lastname: Lee
authors.forename: Shin
authors.initials: S
authors.lastname: Nieh
authors.forename: Chien-Ping
authors.initials: CP
authors.lastname: Chiang
authors.forename: Wei-Ming
authors.initials: WM
authors.lastname: Wang
authors.forename: Jong-Shiaw
authors.initials: JS
authors.lastname: Jin
mesh_terms: D000199:Actins; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002352:Carrier Proteins / Q000096:biosynthesis*; D002648:Child; D051356:Cortactin / Q000096:biosynthesis*; D003593:Cytoplasm / Q000378:metabolism / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D051034:Inhibitor of Apoptosis Proteins; D008297:Male; D008840:Microfilament Proteins / Q000096:biosynthesis*; D008869:Microtubule-Associated Proteins / Q000096:biosynthesis*; D008875:Middle Aged; D009363:Neoplasm Proteins; D009508:Nevus, Pigmented / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D012867:Skin / Q000378:metabolism / Q000473:pathology*; D012878:Skin Neoplasms / Q000453:epidemiology / Q000378:metabolism* / Q000473:pathology; D015996:Survival Rate / Q000639:trends; D000077022:Survivin; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000199:Actins; C107489:BIRC5 protein, human; D002352:Carrier Proteins; D051356:Cortactin; D051034:Inhibitor of Apoptosis Proteins; D008840:Microfilament Proteins; D008869:Microtubule-Associated Proteins; D009363:Neoplasm Proteins; D000077022:Survivin; C020324:fascin