Chromosomal abnormalities associated with mental retardation in female subjects.
Chromosomal abnormalities are thought to be the most common cause of mental retardation (MR). However, apart from a few selected types with typical aneuploidy, like Downs syndrome, Klinefelter syndrome, Turner syndrome, etc., the frequency of detectable chromosomal abnormalities in association with idiopathic MR is very low. In this study, we have investigated chromosomal abnormalities in female MR subjects (n = 150) by high-resolution GTG banding. Of them, 30 cases were diagnosed as Downs syndrome. Among the remaining (n = 120), chromosomal abnormalities/marked polymorphisms were detectable in only three MR cases (0.025).
Dutta
Samikshan
S
Manovikas Biomedical Research and Diagnostic Centre, 482, Madudah, Plot I-24, Sec.-J, E.M. Bypass, Kolkata - 700 107, India.
Shaw
Jyothi
J
Sinha
Swagata
S
Mukhopadhyay
Kanchan
K
Am J Public Health. 1994 Jul;84(7):1164-6
8017547
J Med Genet. 1999 May;36(5):405-11
10353788
Am J Ment Defic. 1986 Nov;91(3):250-6
3799731
Indian J Pediatr. 2005 Aug;72(8):679-85
16131774
Br Med Bull. 1996 Jul;52(3):453-64
8949249
J Med Genet. 2006 Jun;43(6):478-89
16199540
Eur J Hum Genet. 2005 Jan;13(1):6-25
15523501
Stain Technol. 1965 Nov;40(6):333-8
5866557
Fertil Steril. 2009 Jul;92(1):88-95
18692838