Novel chemoenzymatic methodology for the regioselective glycine loading on polyhydroxy compounds.
In the present work, we have developed a highly efficient temperature-dependent chemo-enzymatic methodology for the regioselective synthesis of novel esters of glycerol, G1 tri-glycerol dendrons and related esters for the first time using 4-nitrophenyl 2-(tert-butoxycarbonyl)acetate (Boc-gly-Ph-pNO(2)) (2) as the acylating agent. This methodology offers efficient and controlled loading of amino acid (glycine) on polyhydroxy compounds.
Malhotra
Shashwat
S
Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India.
Calderón
Marcelo
M
Prasad
Ashok K
AK
Parmar
Virinder S
VS
Haag
Rainer
R
D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D005990:Glycerol / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D005998:Glycine / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013696:Temperature
D004952:Esters; D005990:Glycerol; D005998:Glycine