Determination and characterization of hydroxylated polychlorinated biphenyls (OH-PCBs) in serum and adipose tissue of Japanese women diagnosed with breast cancer.
In the present study, we analyze and characterize the levels of PCBs and OH-PCBs in serum and breast adipose tissue, and measure TH (total 3,5,5'-triiodothyronine (tT3) and total l-thyroxine (tT4)) levels in serum of Japanese women diagnosed with breast cancer (n = 51) to know how PCBs affect thyroid hormone homeostasis. Concentrations of Sigma(90)OH-PCBs in serum and adipose tissues were 630 pg g(-1) serum wet wt. and 140 pg/ g(-1) lipid wt., respectively, and the levels of OH-PCBs in adipose tissues were 4-5 times lower than in serum. The tT3 and tT4 concentrations in serum (n = 20) were 1.3 ng g(-1) serum wet wt. and 62 ng g(-1) serum wet wt., respectively. Among all the OH-PCBs, 4'-OH-CB101/120, 4-OH-CB107/4'-OH-CB108, 3'-OH-CB138, 4-OH-CB146, 3-OH-CB153, 4'-OH-CB172, and 4-OH-CB187 were the dominant isomers in serum. No significant correlation between the concentrations of the TH and OH-PCBs in serum was observed (p > 0.05). The results indicated that the relationship between the OH-PCB levels and the thyroid hormone markers was rare. From analysis of two kinds of human biological samples, it was estimated that OH-PCBs have little effect on thyroid hormone homeostasis.
Nomiyama
Kei
K
Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Center for Marine Environmental Studies (CMES), Ehime University, Japan.
Yonehara
Tomonori
T
Yonemura
Saori
S
Yamamoto
Megumi
M
Koriyama
Chihaya
C
Akiba
Suminori
S
Shinohara
Ryota
R
Koga
Minoru
M
D000273:Adipose Tissue / Q000378:metabolism*; D001943:Breast Neoplasms / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D006900:Hydroxylation; D007564:Japan; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000378:metabolism*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D011078:Polychlorinated Biphenyls; D013974:Thyroxine