New strategies in head and neck cancer: understanding resistance to epidermal growth factor receptor inhibitors.
The epidermal growth factor receptor (EGFR) is a validated target in squamous cell carcinoma of the head and neck (HNSCC). However, despite high expression of EGFR in these cancers, EGFR inhibitor monotherapy has only had modest activity. Potential mechanisms of resistance to EGFR-targeted therapies involve EGFR and Ras mutations, epithelial-mesenchymal transition, and activation of alternative and downstream pathways. Strategies to optimize EGFR-targeted therapy in head and neck cancer involve not only the selection for patients most likely to benefit but also the use of combination therapies to target the network of pathways involved in tumor growth, invasion, angiogenesis, and metastasis.
Chen
Lucy F
LF
University of Chicago, Chicago, Illinois 60637, USA.
Cohen
Ezra E W
EE
Grandis
Jennifer R
JR
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm / Q000187:drug effects* / Q000235:genetics; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000235:genetics; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D006801:Humans; D008954:Models, Biological; D009154:Mutation
D066246:ErbB Receptors
Ann Oncol. 2008 Apr;19(4):717-23
17974556
Cancer Res. 2005 Oct 15;65(20):9455-62
16230409
J Clin Oncol. 2004 Jan 1;22(1):77-85
14701768
J Clin Invest. 2008 Jul;118(7):2609-19
18568074
Cancer Res. 2008 May 1;68(9):3314-22
18451158
J Clin Oncol. 2013 Apr 10;31(11):1405-14
23460714
Cancer Res. 2009 Apr 15;69(8):3256-61
19351834
Cancer Res. 2007 Oct 1;67(19):9304-14
17909038
J Clin Oncol. 2009 Mar 10;27(8):1235-42
19204206
Curr Protoc Hum Genet. 2008 Apr;Chapter 10:Unit 10.11
18428421
Clin Cancer Res. 2006 Jul 1;12(13):4103-11
16818711
Cell Growth Differ. 2002 Aug;13(8):355-62
12193474
Mol Cancer Ther. 2008 Nov;7(11):3499-508
18974395
J Clin Oncol. 2005 Dec 1;23(34):8646-54
16314626
Oral Oncol. 2009 Oct;45(10):e161-6
19628422
Science. 2007 Oct 12;318(5848):287-90
17872411
Int J Cancer. 2007 Apr 15;120(8):1731-8
17236202
Innate Immun. 2009 Apr;15(2):91-100
19318419
Methods Mol Biol. 2009;542:335-49
19565911
J Biol Chem. 2003 Aug 22;278(34):31574-83
12771142
Cancer Res. 2009 Mar 1;69(5):1851-7
19223544
Clin Cancer Res. 2004 Nov 15;10(22):7764-74
15570011
J Clin Oncol. 2008 Mar 1;26(7):1119-27
18309947
Cancer Res. 2001 Jul 1;61(13):5090-101
11431346
Cancer Res. 2005 Jun 15;65(12):5076-83
15958551
Cancer Immunol Immunother. 2009 Nov;58(11):1853-64
19319529
Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):4138-43
12640143
J Clin Oncol. 2005 Sep 1;23(25):5900-9
16043828
Clin Cancer Res. 2005 Nov 15;11(22):8105-8
16299242
Biochem Pharmacol. 2008 Mar 1;75(5):1035-44
18191814
Clin Cancer Res. 2009 Jan 15;15(2):532-42
19147758
J Pharmacol Exp Ther. 1999 Nov;291(2):739-48
10525095
Eur J Cancer. 2003 Jul;39(10):1348-54
12826036
Cancer Res. 2006 Apr 15;66(8):3992-5
16618717
Cancer Res. 2008 Oct 15;68(20):8322-32
18922904
J Clin Oncol. 2009 Mar 1;27(7):1100-7
19171712
N Engl J Med. 2008 Sep 11;359(11):1116-27
18784101
Cancer Res. 2005 Jan 1;65(1):46-53
15665278
J Clin Oncol. 2000 Nov 1;18(21 Suppl):47S-53S
11060327
J Natl Cancer Inst. 2007 Jun 6;99(11):838-46
17551144
Br J Cancer. 2007 Mar 26;96(6):952-9
17342092
Oncogene. 2008 May 1;27(20):2934-40
18059341
J Clin Oncol. 2008 Jul 1;26(19):3128-37
18474878
J Clin Oncol. 2008 Jul 10;26(20):3351-7
18612151
Int J Oncol. 1998 Nov;13(5):971-4
9772288
Br J Cancer. 2007 Apr 23;96(8):1166-9
17375050
J Clin Oncol. 2006 Jun 20;24(18):2866-72
16717293
Proc Natl Acad Sci U S A. 1994 Oct 11;91(21):10217-21
7937865
Clin Cancer Res. 2005 Dec 15;11(24 Pt 1):8686-98
16361555
Cancer Res. 2003 Jun 1;63(11):2948-56
12782602
Arch Otolaryngol Head Neck Surg. 1994 Jul;120(7):755-60
7912510
Cancer Res. 2004 Dec 15;64(24):9139-43
15604284
J Clin Oncol. 2007 Feb 10;25(5):587-95
17290067
J Clin Oncol. 2003 May 15;21(10):1980-7
12743152
Clin Cancer Res. 2006 Sep 1;12(17):5064-73
16951222
N Engl J Med. 2006 Feb 9;354(6):567-78
16467544
Br J Cancer. 2008 Jan 15;98(1):80-5
18026190
Semin Oncol. 2008 Jun;35(3):274-85
18544442