title: Serotonin precursor 5-hydroxytryptophan disturbs the protective effect of low doses of antibodies to S100B protein during the formation of long-term sensitization.
abstract: We studied the effect of ultralow doses of antibodies to calcium-binding protein S-100B and 5-hydroxytryptophan, a metabolic precursor of serotonin, on the formation of long-term sensitization as a neurobiological model of anxiety and depression. Daily administration of antibodies to S-100B to edible snail before the formation of long-term sensitization prevents its development. 5-Hydroxytryptophan administered before the formation of long-term sensitization abolished the protective effect of antibodies to S-100B protein.
authors.affiliation: Kazan' Physicotechnical Institute, Russian Academy of Sciences, Novosibirsk.
authors.forename: R R
authors.initials: RR
authors.lastname: Tagirova
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Timoshenko
authors.forename: Kh L
authors.initials: KhL
authors.lastname: Gainutdinov
authors.forename: M B
authors.initials: MB
authors.lastname: Shtark
authors.forename: O I
authors.initials: OI
authors.lastname: Epshtein
mesh_terms: D006916:5-Hydroxytryptophan / Q000494:pharmacology*; D000818:Animals; D000906:Antibodies / Q000276:immunology* / Q000494:pharmacology*; D006372:Helix, Snails / Q000166:cytology / Q000187:drug effects; D009414:Nerve Growth Factors / Q000276:immunology*; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000276:immunology*
chemical_list: D000906:Antibodies; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D006916:5-Hydroxytryptophan