Role of RNA-Binding Proteins in Colorectal Carcinogenesis.
RNA-binding proteins (RBPs) play key roles in the posttranscriptional regulation of gene expression. RBPs control various posttranscriptional events, including splicing, polyadenylation, mRNA stability, transport, and translation. It is becoming apparent that RBPs play a significant role in pathophysiologic conditions such as inflammation and cancer. More importantly, we and others have begun dissecting the role of mRNA stability and translation in regulating gene expression, dysregulation of which has serious consequences for the fate of the cell. In this article, we discuss this emerging area of posttranscriptional gene regulation and the role of RBPs in the aberrant expression of proteins in tumorigenesis.
Anant
Shrikant
S
Section of Digestive Diseases and Nutrition, Department of Internal Medicine, University of Oklahoma Health Sciences Center, 920 Stanton L. Young Boulevard WP1345, Oklahoma City, OK 73104, USA; Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Houchen
Courtney W
CW
Pawar
Vaibhav
V
Ramalingam
Satish
S
EMBO J. 1998 Jun 15;17(12):3448-60
9628880
Gastroenterology. 1994 Oct;107(4):1183-8
7926468
Curr Opin Cell Biol. 1991 Apr;3(2):269-75
1883620
J Mol Med (Berl). 2002 Jul;80(7):431-42
12110949
Cancer J. 2008 Jan-Feb;14(1):46-53
18303483
Int J Colorectal Dis. 2010 Jan;25(1):17-23
19714342
J Clin Invest. 2001 Dec;108(11):1657-65
11733561
J Biol Chem. 2000 Oct 27;275(43):33951-6
10930401
Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13873-8
15358864
Oncogene. 2003 Jun 5;22(23):3554-61
12789264
Cancer Res. 2008 Nov 15;68(22):9469-78
19010922
Cell Signal. 2008 Dec;20(12):2165-73
18585896
Clin Cancer Res. 2006 Apr 15;12(8):2404-13
16638845
J Cell Sci. 2002 Apr 1;115(Pt 7):1355-9
11896183
Gene. 1998 Nov 26;223(1-2):21-31
9858671
Mod Pathol. 2006 Sep;19(9):1261-9
16799479
Gastroenterology. 2007 Mar;132(3):1055-65
17383427
Cell. 1992 Feb 7;68(3):407-10
1310893
Curr Opin Neurobiol. 2008 Oct;18(5):516-23
18929657
Hum Mol Genet. 1999 Jan;8(1):53-60
9887331
Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):1865-70
15684048
Cell Mol Life Sci. 2001 Feb;58(2):266-77
11289308
Mol Cell. 2009 Jul 31;35(2):181-90
19647515
Biochem Biophys Res Commun. 1997 Jul 30;236(3):804-7
9245737
J Biol Chem. 2003 Sep 26;278(39):37637-47
12826679
J Cell Biochem. 2007 Apr 15;100(6):1477-92
17133347
J Biol Chem. 2008 May 9;283(19):13289-301
18211890
Neuron. 1994 Jul;13(1):67-81
8043282
Mol Cell. 2003 Jan;11(1):113-26
12535526
Gene. 1999 Sep 3;237(1):135-42
10524244
Oncogene. 2003 Oct 16;22(46):7146-54
14562043
Am J Physiol Gastrointest Liver Physiol. 2008 May;294(5):G1235-44
18325984
Hum Mol Genet. 1995 Dec;4(12):2307-11
8634703
Am J Physiol Gastrointest Liver Physiol. 2008 Apr;294(4):G1025-32
18292181
Mol Cell Biol. 1999 Jun;19(6):4311-23
10330172
Gastroenterology. 2009 May;136(5):1669-79
19208339
J Biol Chem. 2003 Apr 18;278(16):13928-35
12578839
Oncogene. 2008 Jul 31;27(33):4544-56
18427544
Mol Cell Biol. 2001 Feb;21(4):1285-96
11158314
Mol Cell Neurosci. 2006 Jan;31(1):85-96
16214366
RNA. 2005 Dec;11(12):1869-83
16314458
Dev Biol. 1996 Jun 15;176(2):230-42
8660864
Gastroenterology. 2008 May;134(5):1448-58
18471519
Cell. 2008 Apr 18;133(2):213-6
18423193
J Biol Chem. 2004 Apr 23;279(17):17756-64
14761971
Am J Physiol Gastrointest Liver Physiol. 2008 Apr;294(4):G971-81
18258790