Nuclear translocation of nuclear factor Kappa B in first trimester deciduas and chorionic villi in early spontaneous miscarriage women.
The nuclear factor kappa B is widely expressed in the distinct subpopulations of chorionic villi and deciduas of first-trimester pregnancies. We examined the cellular distribution and expression of nuclear factor kappa B in the human first-trimester chorionic villi and deciduas of women with early spontaneous miscarriage and viable pregnancy by confocal laser scanning microscope and immunohistochemistry. There is a greater nuclear translocation of nuclear factor kappa B is restricted to villous stromal cells, decidual stromal cells, glandular epithelial cells and vessel endothelial cells in early spontaneous miscarriage than in viable pregnancies. Collectively these observations suggest that over-activation of nuclear factor kappa B has a relationship with early spontaneous miscarriages.
Wang
Li-Qin
LQ
Xi'an Medical College, Xi'an, China.
Yu
Xue-Wen
XW
Center of Maternal and Child Health, First Affiliated Hospital of Medical School in Xi'an Jiaotong University, Xi'an, China.
Yan
Chun-Fang
CF
Department of Gynecology & Obstetrics, Fourth Hospital of Xi'an City, Xi'an, China.
Wang
Xiang
X
Xi'an Medical College, Xi'an, China.
D000022:Abortion, Spontaneous / Q000209:etiology* / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D002824:Chorionic Villi / Q000378:metabolism*; D003656:Decidua / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018613:Microscopy, Confocal; D016328:NF-kappa B / Q000378:metabolism*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D017154:Stromal Cells / Q000378:metabolism; D051996:Transcription Factor RelA / Q000378:metabolism
D016328:NF-kappa B; D051996:Transcription Factor RelA
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