Antimicrobial, antiviral and cytotoxic activity of extracts and constituents from Polygonum spectabile Mart.
Polygonum spectabile is used in Brazil for treatment of several infection diseases. Extracts and constituents isolated from this species were evaluated for cytotoxicity and effects on 15 bacterias and yeasts as well on 4 viruses strains (HHV-1, VACV-WR, EMCV, DEN-2). Less polar extracts were effective against Staphylococcus aureus, Bacillus subtillis, Micrococcus luteus, M. canis and Tricophyton mentagrophytes and T. rubrum. Two known chalcones and 3-O-β-D-glucosyl-β-sitosterol were isolated. The ethanol extract was the only one to show antiviral activity (CE50 < 30 μg/ml). One chalcone has inhibited the growth of several bacteria and was significantly active against dermathophytes. The 3 compounds isolated have shown moderate cytotoxicity against Vero and LLCMK(2) cells (CC(50) < 50 μg/ml). These results support the use of P. spectabile as antimicrobial agent.
Brandão
Geraldo Célio
GC
Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, UFMG, Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil.
Kroon
Erna Gessien
EG
Duarte
Maria Gorette R
MG
Braga
Fernão Castro
FC
de Souza Filho
José Dias
JD
de Oliveira
Alaíde Braga
AB
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002460:Cell Line; D047188:Chalcones / Q000302:isolation & purification / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D003603:Cytotoxins / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D028502:Polygonum / Q000737:chemistry*; D012855:Sitosterols / Q000302:isolation & purification / Q000494:pharmacology*; D014709:Vero Cells; D014780:Viruses / Q000187:drug effects; D015003:Yeasts / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000998:Antiviral Agents; D047188:Chalcones; D003603:Cytotoxins; D010936:Plant Extracts; D012855:Sitosterols