title: Acute restraint stress increases the frequency of vinblastine-induced micronuclei in mouse bone marrow cells.
abstract: Acute physiological stress induces remarkable effects on the nervous, endocrine, and immune systems and also on cellular metabolism and cell division processes. Stress-induced instability of cellular mechanisms might play an important role in increasing cell division disorders. In this study, a relationship between stress and micronucleus (MN) induction in mouse (balb/c) bone marrow cells following vinblastine treatment, or stress or stress and vinblastine treatment in comparison to a non-stressed control group was investigated. In order to test the effects of treatments on MN induction, an in vivo MN assay was performed on bone marrow cells. The results revealed a significantly greater increase in MNs in bone marrow cells (polychromatic erythrocytes) from the stressed/vinblastine treated mice. The data indicate the ability of exposure to an emotional stressor to enhance the damaging actions on bone marrow cells of an aneugenic agent.
authors.affiliation: Department of Biology, Faculty of Sciences, Ferdowsi University of Mashhad, Mashhad, Iran.
authors.forename: Amir Mohammad
authors.initials: AM
authors.lastname: Malvandi
authors.forename: Farhang
authors.initials: F
authors.lastname: Haddad
authors.forename: Ali
authors.initials: A
authors.lastname: Moghimi
mesh_terms: D000208:Acute Disease; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004644:Emotions; D004912:Erythrocytes / Q000187:drug effects / Q000502:physiology; D007399:Interphase / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D048629:Micronuclei, Chromosome-Defective / Q000139:chemically induced*; D008938:Mitosis / Q000187:drug effects / Q000502:physiology; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology*; D050257:Tubulin Modulators / Q000633:toxicity*; D014747:Vinblastine / Q000633:toxicity*
chemical_list: D050257:Tubulin Modulators; D014747:Vinblastine