title: Performance on the clock drawing task correlates with FMRI response to a visuospatial task in Alzheimer's disease.
abstract: The clock drawing (CD) task involves visual integration skills associated with parietal lobe function. Seven mild Alzheimer's Disease (AD) patients and 11 healthy elderly controls (EC) underwent functional magnetic resonance imaging (fMRI) scanning while viewing a radial motion (RM) task. This RM task in EC activated the bilateral secondary visual cortex and parietal regions, whereas AD patients activated only the right-sided secondary visual cortex. The magnitude of the fMRI signal in the left superior parietal lobe was positively correlated with performance on the CD task in AD patients. These findings suggest that complex visuospatial processing impairments reflect the underlying AD neuropathology in parietal regions.
authors.affiliation: Sheffield Cognition and Neuroimaging Laboratory (SCANLab) Academic Clinical Psychiatry, University of Sheffield School of Medicine, Sheffield S5 7JT, UK.
authors.forename: Randolph W
authors.initials: RW
authors.lastname: Parks
authors.forename: Subha N
authors.initials: SN
authors.lastname: Thiyagesh
authors.forename: Tom F D
authors.initials: TF
authors.lastname: Farrow
authors.forename: Leanne
authors.initials: L
authors.lastname: Ingram
authors.forename: Katherine
authors.initials: K
authors.lastname: Wilkinson
authors.forename: Michael D
authors.initials: MD
authors.lastname: Hunter
authors.forename: Iain D
authors.initials: ID
authors.lastname: Wilkinson
authors.forename: Claire
authors.initials: C
authors.lastname: Young
authors.forename: Peter W R
authors.initials: PW
authors.lastname: Woodruff
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology* / Q000523:psychology*; D016022:Case-Control Studies; D007839:Functional Laterality; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D010296:Parietal Lobe / Q000503:physiopathology; D011597:Psychomotor Performance / Q000502:physiology*; D013028:Space Perception / Q000502:physiology*; D014793:Visual Cortex / Q000503:physiopathology; D014796:Visual Perception / Q000502:physiology*