Emergence of extended-spectrum beta-lactamase and fluoroquinolone resistance genes among Irish multidrug-resistant isolates.
This study sought to identify mechanisms behind resistance to third-generation cephalosporins and ciprofloxacin in Irish multidrug-resistant Enterobacteriaceae isolates. The most prevalent extended-spectrum beta-lactamase genes identified were bla SHV-12 and bla CTX-M-15. These were associated with the fluoroquinolone resistance genes aac(6')-IB-cr, qnrA and qnrB, not previously reported in Irish isolates.
Mac Aogáin
Micheál
M
Department of Microbiology, BIOMERIT Research Centre, University College Cork, Cork, Ireland.
Mooij
Marlies J
MJ
Adams
Claire
C
Clair
Jim
J
O'Gara
Fergal
F
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D002511:Cephalosporins / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology*; D005798:Genes, Bacterial; D005838:Genotype; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D001618:beta-Lactamases / Q000235:genetics*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002511:Cephalosporins; D002939:Ciprofloxacin; D001618:beta-Lactamases