title: Immunosuppressive resveratrol aneuploids from Hopea chinensis.
abstract: Two novel resveratrol aneuploids, hopeachinols A (1) and B (2), as well as a potent immunosuppressive polyphenol diptoindonesin G (3) were characterized from the ethanol extract of Hopea chinensis stem barks. The structure of the polyphenols was accommodated by comprehensive spectroscopic analysis with the absolute stereochemistry determined by the CD approach coupled with theoretical ECD spectra computer-generated through the Gaussian 03 program. The distinct structure and biological profile of 3 recommended it as a starting molecule for the relevant drug discovery.
authors.affiliation: Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, School of Lifesciences, Nanjing University, Nanjing 210093, China.
authors.forename: Hui Ming
authors.initials: HM
authors.lastname: Ge
authors.forename: Wen Hao
authors.initials: WH
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Shen
authors.forename: Nan
authors.initials: N
authors.lastname: Jiang
authors.forename: Zhi Kai
authors.initials: ZK
authors.lastname: Guo
authors.forename: Qiong
authors.initials: Q
authors.lastname: Luo
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Ma
authors.forename: Ren Xiang
authors.initials: RX
authors.lastname: Tan
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002942:Circular Dichroism; D053958:Dipterocarpaceae / Q000737:chemistry*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D018547:Plant Stems / Q000737:chemistry; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001572:Benzofurans; D006576:Heterocyclic Compounds, 4 or More Rings; D007166:Immunosuppressive Agents; D013267:Stilbenes; C543798:diptoindonesin G; C553755:hopeachinol A; C553756:hopeachinol B; D000077185:Resveratrol