title: What does the amygdala contribute to social cognition?
abstract: The amygdala has received intense recent attention from neuroscientists investigating its function at the molecular, cellular, systems, cognitive, and clinical level. It clearly contributes to processing emotionally and socially relevant information, yet a unifying description and computational account have been lacking. The difficulty of tying together the various studies stems in part from the sheer diversity of approaches and species studied, in part from the amygdala's inherent heterogeneity in terms of its component nuclei, and in part because different investigators have simply been interested in different topics. Yet, a synthesis now seems close at hand in combining new results from social neuroscience with data from neuroeconomics and reward learning. The amygdala processes a psychological stimulus dimension related to saliency or relevance; mechanisms have been identified to link it to processing unpredictability; and insights from reward learning have situated it within a network of structures that include the prefrontal cortex and the ventral striatum in processing the current value of stimuli. These aspects help to clarify the amygdala's contributions to recognizing emotion from faces, to social behavior toward conspecifics, and to reward learning and instrumental behavior.
authors.affiliation: California Institute of Technology, Pasadena, California 91125, USA. radolphs@hss.caltech.edu
authors.forename: Ralph
authors.initials: R
authors.lastname: Adolphs
mesh_terms: D000679:Amygdala / Q000502:physiology*; D003071:Cognition; D004644:Emotions / Q000502:physiology; D005239:Fear / Q000502:physiology; D006801:Humans; D007858:Learning / Q000502:physiology; D012201:Reward
references.citation: J Neurosci Methods. 2009 May 30;180(1):57-70
references.pmid: 19427530
references.citation: Brain Res Brain Res Rev. 2004 May;45(2):96-103
references.pmid: 15145620
references.citation: J Cogn Neurosci. 2002 Jul 1;14(5):709-20
references.pmid: 12167256
references.citation: Soc Cogn Affect Neurosci. 2007 Jun;2(2):73-83
references.pmid: 18392107
references.citation: Science. 2003 Aug 22;301(5636):1104-7
references.pmid: 12934011
references.citation: J Neurosci. 2001 Mar 15;21(6):2067-74
references.pmid: 11245690
references.citation: Eur J Neurosci. 1999 Dec;11(12):4403-18
references.pmid: 10594668
references.citation: Emotion. 2006 Feb;6(1):73-81
references.pmid: 16637751
references.citation: J Neurophysiol. 2009 Apr;101(4):1749-54
references.pmid: 19144740
references.citation: Exp Brain Res. 2008 Mar;186(1):47-57
references.pmid: 18049816
references.citation: J Comp Neurol. 2005 Jun 13;486(4):295-317
references.pmid: 15846786
references.citation: Neuron. 1997 May;18(5):753-65
references.pmid: 9182800
references.citation: Soc Cogn Affect Neurosci. 2009 Jun;4(2):127-33
references.pmid: 19151376
references.citation: Nat Neurosci. 2008 Dec;11(12):1381-2
references.pmid: 18978778
references.citation: Behav Brain Res. 2007 Jan 25;176(2):210-5
references.pmid: 17098297
references.citation: Am J Psychiatry. 2009 Apr;166(4):467-75
references.pmid: 19223437
references.citation: Brain Res Rev. 2008 Jun;58(1):57-70
references.pmid: 18076995
references.citation: Psychol Sci. 2002 Mar;13(2):135-41
references.pmid: 11933997
references.citation: Nature. 1994 Dec 15;372(6507):669-72
references.pmid: 7990957
references.citation: Vision Res. 2001 Aug;41(17):2261-71
references.pmid: 11448718
references.citation: Nat Neurosci. 2008 Jul;11(7):843-50
references.pmid: 18552843
references.citation: J Neurophysiol. 2009 Apr;101(4):1823-35
references.pmid: 19193767
references.citation: Behav Neurol. 1993;6(3):167-70
references.pmid: 24487116
references.citation: Emotion. 2009 Apr;9(2):147-63
references.pmid: 19348528
references.citation: Front Behav Neurosci. 2009 Nov 16;3:50
references.pmid: 19949466
references.citation: Biol Psychiatry. 2008 May 1;63(9):852-7
references.pmid: 17949693
references.citation: J Neurosci. 2002 Nov 1;22(21):9502-12
references.pmid: 12417674
references.citation: Neuropsychologia. 2009 Apr;47(5):1386-9
references.pmid: 19428403
references.citation: Neuron. 2007 Aug 16;55(4):545-55
references.pmid: 17698008
references.citation: J Comp Neurol. 2009 Feb 20;512(6):717-25
references.pmid: 19065620
references.citation: Science. 2009 Sep 4;325(5945):1258-61
references.pmid: 19729657
references.citation: Anat Embryol (Berl). 2005 Dec;210(5-6):343-52
references.pmid: 16208455
references.citation: Proc Natl Acad Sci U S A. 2009 Sep 29;106(39):16841-6
references.pmid: 19805383
references.citation: Nat Neurosci. 2005 Jun;8(6):828-34
references.pmid: 15880108
references.citation: Behav Neurosci. 2001 Jun;115(3):515-44
references.pmid: 11439444
references.citation: Neuropsychologia. 2007 Sep 20;45(12):2772-82
references.pmid: 17561172
references.citation: Nature. 2009 Jan 22;457(7228):475-9
references.pmid: 19158795
references.citation: J Neurosci. 2009 Jul 15;29(28):9123-6
references.pmid: 19605649
references.citation: Neuropsychologia. 2003;41(2):235-40
references.pmid: 12459222
references.citation: Science. 2002 Jul 19;297(5580):400-3
references.pmid: 12130784
references.citation: J Neurosci. 2009 May 6;29(18):5985-91
references.pmid: 19420264
references.citation: Science. 1995 Aug 25;269(5227):1115-8
references.pmid: 7652558
references.citation: Neuropsychologia. 1996 Jan;34(1):31-9
references.pmid: 8852691
references.citation: Neuropsychologia. 2003;41(10):1281-9
references.pmid: 12757901
references.citation: J Comp Physiol Psychol. 1954 Jun;47(3):173-8
references.pmid: 13163250
references.citation: Nat Neurosci. 2005 Jan;8(1):20-1
references.pmid: 15592465
references.citation: Biol Psychiatry. 2009 Nov 15;66(10):964-71
references.pmid: 19699473
references.citation: Learn Mem. 2009 Feb 17;16(3):187-92
references.pmid: 19228588
references.citation: Psychol Sci. 2005 Mar;16(3):184-9
references.pmid: 15733197
references.citation: Am J Psychiatry. 1999 May;156(5):675-82
references.pmid: 10327898
references.citation: Neuropsychology. 2001 Jul;15(3):396-404
references.pmid: 11499994
references.citation: J Neurosci. 2006 Nov 29;26(48):12387-96
references.pmid: 17135400
references.citation: Neuropsychologia. 2008;46(9):2364-70
references.pmid: 18479717
references.citation: Nature. 2001 May 17;411(6835):305-9
references.pmid: 11357132
references.citation: Nat Neurosci. 2009 Oct;12(10):1226-7
references.pmid: 19718035
references.citation: Nature. 2005 Jun 23;435(7045):1102-7
references.pmid: 15973409
references.citation: J Neurosci. 1995 Oct;15(10):6846-55
references.pmid: 7472442
references.citation: Neuron. 2002 Oct 10;36(2):265-84
references.pmid: 12383781
references.citation: J Neurophysiol. 2007 Feb;97(2):1671-83
references.pmid: 17093126
references.citation: Nature. 2006 Feb 16;439(7078):865-70
references.pmid: 16482160
references.citation: J Neurosci. 2007 May 30;27(22):5958-66
references.pmid: 17537966
references.citation: J Neurosci. 2000 Jun 1;20(11):4311-9
references.pmid: 10818166
references.citation: Behav Neurosci. 2006 Aug;120(4):761-86
references.pmid: 16893284
references.citation: Neuropsychologia. 2007 Jan 28;45(2):236-44
references.pmid: 16970965
references.citation: J Neurosci. 1995 Sep;15(9):5879-91
references.pmid: 7666173
references.citation: J Neuropsychiatry Clin Neurosci. 2008 Winter;20(1):86-92
references.pmid: 18305289
references.citation: Nat Neurosci. 2009 Nov;12(11):1367-9
references.pmid: 19783994
references.citation: J Cogn Neurosci. 2004 Dec;16(10):1730-45
references.pmid: 15701225
references.citation: Nat Neurosci. 2000 Sep;3(9):946-53
references.pmid: 10966627
references.citation: Psychol Sci. 2008 Feb;19(2):152-60
references.pmid: 18271863
references.citation: Science. 2003 Jun 6;300(5625):1536
references.pmid: 12791983
references.citation: Learn Mem. 1997 Sep-Oct;4(3):291-300
references.pmid: 10456070
references.citation: Nature. 2005 Jan 6;433(7021):68-72
references.pmid: 15635411
references.citation: Cortex. 2010 Apr;46(4):490-7
references.pmid: 19560133
references.citation: Neuroscience. 2009 Sep 15;162(4):1429-36
references.pmid: 19460420
references.citation: Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):15031-6
references.pmid: 19706473
references.citation: Trends Cogn Sci. 2007 Nov;11(11):489-97
references.pmid: 17988930
references.citation: Psychol Sci. 2008 Nov;19(11):1131-9
references.pmid: 19076485
references.citation: Nat Rev Neurosci. 2007 Aug;8(8):577-81
references.pmid: 17643087
references.citation: J Neurosci. 2005 Sep 28;25(39):8903-7
references.pmid: 16192380
references.citation: Nat Neurosci. 2005 Jul;8(7):860-1
references.pmid: 15951808
references.citation: Behav Brain Res. 1990 Dec 21;41(3):199-213
references.pmid: 2288672
references.citation: Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11737-41
references.pmid: 19567836
references.citation: J Cogn Neurosci. 2009 Mar;21(3):519-28
references.pmid: 18564045
references.citation: J Cogn Neurosci. 1999 Nov;11(6):610-6
references.pmid: 10601742
references.citation: J Comp Neurol. 2007 May 10;502(2):309-24
references.pmid: 17348015
references.citation: Cereb Cortex. 2008 Jan;18(1):145-50
references.pmid: 17490992
references.citation: Neuron. 2008 Aug 28;59(4):648-61
references.pmid: 18760700
references.citation: Physiol Behav. 2007 Sep 10;92(1-2):180-5
references.pmid: 17599366
references.citation: Curr Biol. 2007 Oct 23;17(20):R868-74
references.pmid: 17956742
references.citation: Neuropsychologia. 1999 Sep;37(10):1135-41
references.pmid: 10509835
references.citation: J Comp Physiol Psychol. 1956 Aug;49(4):381-91
references.pmid: 13345917
references.citation: Neuroscience. 2009 Sep 15;162(4):881-91
references.pmid: 19482067
references.citation: J Neurosci. 2006 Sep 6;26(36):9264-71
references.pmid: 16957082
references.citation: Neuroimage. 2006 May 1;30(4):1441-8
references.pmid: 16368249
references.citation: Neuron. 2003 Aug 28;39(5):855-67
references.pmid: 12948451
references.citation: J Neurosci. 2004 Nov 17;24(46):10364-8
references.pmid: 15548650
references.citation: Nat Neurosci. 2004 Apr;7(4):411-6
references.pmid: 15004563
references.citation: Hum Mol Genet. 2002 Apr 1;11(7):833-40
references.pmid: 11929856
references.citation: Nat Neurosci. 2005 Apr;8(4):512-8
references.pmid: 15735643
references.citation: Neuropsychology. 2000 Oct;14(4):526-36
references.pmid: 11055255
references.citation: Biol Psychiatry. 2001 Feb 15;49(4):309-16
references.pmid: 11239901
references.citation: Nat Neurosci. 2009 May;12(5):535-40
references.pmid: 19396166
references.citation: Neuropsychologia. 1999 Sep;37(10):1111-7
references.pmid: 10509833
references.citation: Cogn Neuropsychiatry. 2006 May;11(3):219-32
references.pmid: 17354069
references.citation: Brain Cogn. 2003 Jun;52(1):61-9
references.pmid: 12812805
references.citation: Science. 2005 Dec 9;310(5754):1680-3
references.pmid: 16339445
references.citation: J Neurosci. 2002 Feb 1;22(3):1027-33
references.pmid: 11826131
references.citation: Brain. 2003 Dec;126(Pt 12):2627-37
references.pmid: 12937075
references.citation: J Neurophysiol. 2007 Feb;97(2):1379-87
references.pmid: 17182913
references.citation: J Cogn Neurosci. 2002 Nov 15;14(8):1264-74
references.pmid: 12495531
references.citation: Nat Neurosci. 2003 Feb;6(2):196-202
references.pmid: 12536208
references.citation: Neuroimage. 2003 Jul;19(3):513-31
references.pmid: 12880784
references.citation: Nat Neurosci. 2003 Jun;6(6):624-31
references.pmid: 12740580
references.citation: Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1680-5
references.pmid: 9990084
references.citation: Nat Neurosci. 2009 Oct;12(10):1224-5
references.pmid: 19718036
references.citation: J Neurosci. 2009 Sep 16;29(37):11614-8
references.pmid: 19759308
references.citation: Curr Opin Neurobiol. 2008 Apr;18(2):166-72
references.pmid: 18655833
references.citation: Neuron. 1996 Nov;17(5):875-87
references.pmid: 8938120
references.citation: Neuropsychologia. 1999 Oct;37(11):1285-92
references.pmid: 10530728
references.citation: Neurosci Lett. 2009 Apr 3;453(2):126-30
references.pmid: 19356607
references.citation: Nature. 1996 Oct 31;383(6603):812-5
references.pmid: 8893004
references.citation: Nature. 1998 Jun 4;393(6684):470-4
references.pmid: 9624002
references.citation: Trends Neurosci. 1998 Jul;21(7):294-9
references.pmid: 9683321
references.citation: Learn Mem. 2009 May 23;16(6):357-61
references.pmid: 19470650
references.citation: J Neurosci. 2001 Jun 1;21(11):4090-103
references.pmid: 11356897
references.citation: Trends Cogn Sci. 2007 Dec;11(12):499-500
references.pmid: 18024182
references.citation: Brain. 1995 Feb;118 ( Pt 1):15-24
references.pmid: 7895001
references.citation: J Neurosci. 2004 Jul 14;24(28):6392-401
references.pmid: 15254095
references.citation: Acta Derm Venereol Suppl (Stockh). 1973;53:1-52
references.pmid: 4590183
references.citation: Nat Rev Neurosci. 2002 Jul;3(7):563-73
references.pmid: 12094212
references.citation: J Cogn Neurosci. 2004 Apr;16(3):453-62
references.pmid: 15072680
references.citation: Neuroscience. 2001;106(4):653-8
references.pmid: 11682152
references.citation: Science. 2002 Jun 21;296(5576):2191
references.pmid: 12077407
references.citation: J Comp Neurol. 1996 Mar 04;366(2):223-30
references.pmid: 8698883
references.citation: Perspect Psychol Sci. 2009 May;4(3):274-90
references.pmid: 26158964
references.citation: Trends Neurosci. 1998 Aug;21(8):323-31
references.pmid: 9720596
references.citation: J Neurosci. 2007 Apr 11;27(15):3994-7
references.pmid: 17428974
references.citation: J Cogn Neurosci. 2004 Oct;16(8):1388-411
references.pmid: 15509386
references.citation: Proc Natl Acad Sci U S A. 2010 Feb 23;107(8):3788-92
references.pmid: 20142490
references.citation: Nat Neurosci. 2004 Nov;7(11):1271-8
references.pmid: 15494727
references.citation: Science. 2006 Aug 4;313(5787):684-7
references.pmid: 16888142
references.citation: J Neuropsychiatry Clin Neurosci. 1997 Fall;9(4):606-20
references.pmid: 9447506
references.citation: J Neurosci. 2007 Jan 31;27(5):1054-62
references.pmid: 17267559