QT dispersion in uncomplicated familial Mediterranean fever.
The aim of the study was to further evaluate repolarization dispersion in familial Mediterranean fever (FMF). Findings on 12-lead electrocardiography were compared with 32 patients with uncomplicated FMF and age- and sex-matched control subjects. All procedures followed stringent standards. Repolarization and dispersion parameters were computed with designated computer software, and results of the five beats were subsequently averaged. There were no statistically significant differences between the groups in average QT and average corrected QT interval length, average QT interval dispersion, average QT corrected dispersion, or QT dispersion ratio. During 6 months of follow-up, no cases of sudden death or arrhythmia were documented in either group. Patients with FMF who are continuously treated with low-dose colchicine and have not developed amyloidosis seem to have QT dispersion parameters similar to those of healthy subjects and therefore apparently have no increased risk of adverse cardiac events associated with abnormal repolarization.
Nussinovitch
Naomi
N
Hypertension Unit and Department of Internal Medicine D, Sheba Medical Center, Tel Hashomer, Israel. nussim@clalit.org.il
Livneh
Avi
A
Katz
Keren
K
Langevitz
Pnina
P
Feld
Olga
O
Nussinovitch
Moshe
M
Volovitz
Benjamin
B
Lidar
Merav
M
Nussinovitch
Udi
U
D000293:Adolescent; D000328:Adult; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D016022:Case-Control Studies; D004562:Electrocardiography; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D055815:Young Adult
Ann Noninvasive Electrocardiol. 2006 Jan;11(1):43-51
16472282
Clin Rheumatol. 2009 Jan;28(1):23-8
18716732
Ann Allergy Asthma Immunol. 2007 Dec;99(6):517-21
18219832
Rheumatol Int. 2008 Apr;28(6):513-9
17957370
Heart. 2009 May;95(10):813-8
19074921
Arch Immunol Ther Exp (Warsz). 2009 Mar-Apr;57(2):95-104
19333734
Card Electrophysiol Rev. 2002 Sep;6(3):295-301
12114855
Arthritis Rheum. 1997 Oct;40(10):1879-85
9336425
Isr Med Assoc J. 2001 Jan;3(1):9-12
11344818
J Cardiovasc Electrophysiol. 2006 Mar;17(3):333-6
16643414
Lupus. 2008 Jul;17(7):663-9
18625639
J Am Coll Cardiol. 2000 Nov 15;36(6):1749-66
11092641
Clin Rheumatol. 2008 Feb;27(2):189-94
17646898
Best Pract Res Clin Gastroenterol. 2005 Apr;19(2):199-213
15833688
Semin Arthritis Rheum. 2007 Dec;37(3):182-8
17512038
Mod Rheumatol. 2009;19(5):550-5
19578931
Rheumatol Int. 2006 Apr;26(6):489-96
16283319
Am J Cardiol. 1998 Feb 15;81(4):471-7
9485139
Circulation. 1998 Jun 30;97(25):2543-50
9657475
Pediatr Nephrol. 2003 Sep;18(9):853-9
12836090
J Am Coll Cardiol. 2006 Dec 5;48(11):2351-3
17161270
Pediatr Cardiol. 2009 Aug;30(6):747-51
19340477
Clin Rheumatol. 2007 Sep;26(9):1467-73
17242867