On-line solid phase extraction fast liquid chromatography-tandem mass spectrometry for the analysis of bisphenol A and its chlorinated derivatives in water samples.
In this study an on-line column-switching fast LC-MS/MS method was developed to analyze bisphenol A (BPA) and its chlorinated derivatives in water. Fast liquid chromatographic separation was performed on a C18 reversed phase column based on fused-core particle technology (2.7 microm particle size) providing analysis times shorter than 3 min and high peak efficiencies. The main benefit of this LC system is that it can easily be hyphenated to a conventional on-line preconcentration device allowing the direct analysis of water samples without any pretreatment at concentrations levels down to 60 ng L(-1) and preventing contaminations frequently reported in the analysis of BPA. This on-line SPE fast LC system was coupled to a triple quadrupole mass spectrometer operating in enhanced mass resolution mode (Q1 FWHM=0.7 Th, Q3 FWHM=0.1 Th) in order to minimize interferences and chemical noise. This highly sensitive and selective method was successfully employed to analyze BPA and its chlorinated derivatives in water samples.
Gallart-Ayala
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Department of Analytical Chemistry, University of Barcelona, Martí i Franquès 1-11, Diagonal 647, 08028 Barcelona, Spain.
Moyano
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Galceran
M T
MT
D001559:Benzhydryl Compounds; D002713:Chlorine; D002853:Chromatography, Liquid / Q000379:methods*; D004784:Environmental Monitoring; D010636:Phenols / Q000032:analysis / Q000737:chemistry*; D045483:Rivers / Q000737:chemistry; D012680:Sensitivity and Specificity; D052616:Solid Phase Extraction / Q000379:methods*; D053719:Tandem Mass Spectrometry / Q000379:methods*; D014867:Water / Q000737:chemistry*; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D002713:Chlorine; D010636:Phenols; D014867:Water; C006780:bisphenol A; D000098826:Bisphenol A Compounds