title: In vitro activity of the aminoglycoside antibiotic arbekacin against Acinetobacter baumannii-calcoaceticus isolated from war-wounded patients at Walter Reed Army Medical Center.
abstract: We determined the in vitro MIC of arbekacin against 200 Acinetobacter isolates recovered from wounded soldiers. The median MIC was 2 microg/ml (range, 0.5 to > 64 microg/ml). A total of 97.5% of the isolates had arbekacin MICs of < 8 microg/ml and 86.5% had MICs of < or = 4 microg/ml. There was no association between the arbekacin MIC and susceptibility to 16 other antibiotics or the specimen source (P = 0.7239). Synergy testing suggested an enhanced effect of arbekacin-carbapenem combinations.
authors.affiliation: Infectious Disease Service, Walter Reed Army Medical Center, 6900 Georgia Ave., Washington, DC 20307, USA. michael.zapor@us.army.mil
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Zapor
authors.forename: Melissa
authors.initials: M
authors.lastname: Barber
authors.forename: Amy
authors.initials: A
authors.lastname: Summers
authors.forename: George H
authors.initials: GH
authors.lastname: Miller
authors.forename: Lee Ann
authors.initials: LA
authors.lastname: Feeney
authors.forename: Lynn E
authors.initials: LE
authors.lastname: Eberly
authors.forename: Glenn
authors.initials: G
authors.lastname: Wortmann
mesh_terms: D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000302:isolation & purification; D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology; D003982:Dibekacin / Q000031:analogs & derivatives / Q000494:pharmacology; D006772:Hospitals, Military; D006801:Humans; D008826:Microbial Sensitivity Tests; D014857:Warfare
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D015780:Carbapenems; D003982:Dibekacin; C031986:arbekacin
references.citation: Clin Infect Dis. 2009 Jun 15;48(12):1724-8
references.pmid: 19438394
references.citation: Antimicrob Agents Chemother. 2000 Sep;44(9):2545-6
references.pmid: 10952613
references.citation: Infect Control Hosp Epidemiol. 2008 Jul;29(7):661-3
references.pmid: 18593337
references.citation: Braz J Infect Dis. 2001 Jun;5(3):130-5
references.pmid: 11506776
references.citation: J Korean Med Sci. 2006 Apr;21(2):188-92
references.pmid: 16614499
references.citation: Antimicrob Agents Chemother. 1999 Apr;43(4):727-37
references.pmid: 10103173
references.citation: J Antimicrob Chemother. 1996 Aug;38(2):287-91
references.pmid: 8877544
references.citation: Cold Spring Harb Symp Quant Biol. 1983;47 Pt 1:189-95
references.pmid: 6222863
references.citation: J Trauma. 2008 Feb;64(2):295-9
references.pmid: 18301189
references.citation: J Antimicrob Chemother. 1992 Dec;30(6):871-2
references.pmid: 1289363
references.citation: Clin Infect Dis. 1997 Jan;24 Suppl 1:S46-62
references.pmid: 8994779
references.citation: Antimicrob Agents Chemother. 1980 Feb;17(2):184-7
references.pmid: 7387140
references.citation: Antimicrob Agents Chemother. 2006 Nov;50(11):3763-9
references.pmid: 17065622
references.citation: Clin Infect Dis. 2007 Jan 1;44(1):79-86
references.pmid: 17143821