Long-chain omega-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid dose-dependently reduce fasting serum triglycerides.
The objectives of this review were to determine whether the long-chain omega-3 fatty acids eicosapentaenoic acid and/or docosahexaenoic acid dose-dependently reduce fasting serum triglycerides (TG) and, if so, to create a mathematical model that may be used to predict potential percent reductions in fasting serum TG levels at the recommended intakes of 200-500 mg/day. The assessment included 15 randomized controlled trials that met pre-defined inclusion and exclusion criteria. Across these 15 studies, the dose-response was modeled using a first-order elimination curve. The response variable was defined as percent change from baseline in fasting serum TG, adjusted for the placebo effect. A weighting factor equal to the product of each study's sample size and quality score was used. Using the equation of the dose-response curve, predicted reductions in fasting serum TG levels at the recommended long-chain omega-3 fatty acid intakes of 200-500 mg/day are 3.1 to 7.2%.
Musa-Veloso
Kathy
K
Cantox Health Sciences International, Mississauga, Ontario, Canada. kmusa-veloso@cantox.com
Binns
Malcolm Angus
MA
Kocenas
Alexandra Catherine
AC
Poon
Theresa
T
Elliot
Julie Ann
JA
Rice
Harry
H
Oppedal-Olsen
Hilde
H
Lloyd
Hilary
H
Lemke
Shawna
S
D004281:Docosahexaenoic Acids / Q000008:administration & dosage* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage* / Q000378:metabolism; D005215:Fasting / Q000097:blood; D006801:Humans; D018673:Nutrition Policy; D016032:Randomized Controlled Trials as Topic; D014280:Triglycerides / Q000097:blood*
D014280:Triglycerides; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid