The pain imaging revolution: advancing pain into the 21st century.
The great advances in brain imaging techniques over the last few decades have determined a shift in our understanding of chronic pain conditions and opened the door for new opportunities to develop better diagnoses and perhaps better drug treatments. Neuroimaging has helped shape the concept of chronic pain from a disease affecting mainly the somatosensory system, to a condition in which emotional, cognitive, and modulatory areas of the brain are affected, in addition to degenerative processes. All these contribute to the development and maintenance of pain symptoms and comorbid features, including alterations in anxiety, depression, and cognitive processes. In this article the authors review the current understanding of the brain changes in chronic pain and the developments made possible by the use of various brain imaging techniques. They also discuss the possible applications of brain imaging to developing a "pain phenotype" that could aid in diagnostic and treatment choices of chronic pain conditions.
Borsook
David
D
Department of Radiology, Children's Hospital Boston, Waltham, MA 02453, USA.
Sava
Simona
S
Becerra
Lino
L
D000818:Animals; D001921:Brain / Q000502:physiology; D001931:Brain Mapping / Q000639:trends*; D003952:Diagnostic Imaging / Q000639:trends*; D005544:Forecasting; D006801:Humans; D010146:Pain / Q000175:diagnosis* / Q000503:physiopathology*
Brain. 2008 May;131(Pt 5):1171-96
18048446
Neurology. 2005 Oct 25;65(8):1268-77
16247056
J Pain. 2009 May;10(5):447-85
19411059
Pain. 2009 Jul;144(1-2):95-100
19410366
Curr Pain Headache Rep. 2005 Jun;9(3):184-8
15907256
J Neurosci. 2006 Oct 18;26(42):10646-57
17050704
Neurotherapeutics. 2007 Jul;4(3):316-29
17599699
Brain Cogn. 2002 Jun;49(1):102-13
12027396
Curr Pain Headache Rep. 2007 Jun;11(3):201-7
17504647
PLoS One. 2009 Jun 10;4(6):e5865
19517024
Neuroimage. 2009 Sep;47(3):1077-85
19501658
J Neurosci. 2005 Nov 9;25(45):10390-402
16280578
Anesthesiology. 2004 Feb;100(2):292-301
14739803
Ann N Y Acad Sci. 2009 Mar;1156:260-93
19338512
Anesthesiology. 2006 Jul;105(1):120-7
16810003
Arch Gen Psychiatry. 2008 Feb;65(2):220-31
18250260
Gend Med. 2005 Sep;2(3):137-45
16290886
Br J Anaesth. 2008 Jul;101(1):32-9
18556697
Neuroimage. 2005 Aug 1;27(1):201-9
15921935
Neuroimage. 2004;23 Suppl 1:S275-88
15501097
Eur J Pain. 2006 May;10(4):287-333
16095934
Neuroimage. 2002 Aug;16(4):999-1014
12202088
Exp Neurol. 2003 Nov;184 Suppl 1:S80-8
14597330
Pain Res Manag. 2007 Winter;12(4):245-8
18080042
Rev Neurol (Paris). 2007 Feb;163(2):169-79
17351536
Neurology. 2009 Feb 3;72(5 Suppl):S3-7
19188564
Trends Neurosci. 2002 Jun;25(6):319-25
12086751
J Neurosci. 2001 Dec 15;21(24):9896-903
11739597
Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18195-200
16330766
Mol Pain. 2009 Jun 30;5:34
19566960
Arch Gen Psychiatry. 2002 Sep;59(9):851-8
12215085
Anesth Analg. 2006 Jul;103(1):208-16, table of contents
16790655
J Neurophysiol. 2004 Jan;91(1):533-41
14715722
J Magn Reson Imaging. 2006 Jun;23(6):862-76
16649197
Cerebellum. 2008;7(3):252-72
18418691
Nat Rev Neurosci. 2004 Jun;5(6):483-94
15152198
Anesthesiology. 2004 Dec;101(6):1400-8
15564948
Nat Rev Drug Discov. 2006 May;5(5):411-24
16604100
Pain. 1999 Feb;79(2-3):105-11
10068155
Science. 2004 Feb 20;303(5661):1162-7
14976306
Mol Pain. 2007 Sep 11;3:25
17848191
Neuroimage. 2008 Jun;41(2):252-9
18394924
Neuroimage. 2007 Dec;38(4):720-9
17904390
Neuron. 2009 Jan 29;61(2):203-12
19186163
Neurophysiol Clin. 2000 Oct;30(5):263-88
11126640
Nat Rev Neurosci. 2008 Apr;9(4):314-20
18354400
Pain. 2001 Jan;89(2-3):127-34
11166468
J Neurosci. 2007 Sep 12;27(37):10000-6
17855614
Science. 2002 Mar 1;295(5560):1737-40
11834781
Eur J Pain. 2007 Jan;11(1):7-20
16495096
Pain. 1993 Apr;53(1):3-16
8316386
J Neurol. 2006 Jun;253(6):772-9
16705476
Neuron. 2001 Dec 6;32(5):927-46
11738036
J Neurosci. 2007 Apr 11;27(15):4004-7
17428976
J Neurosci. 2004 Nov 17;24(46):10410-5
15548656
Neurosci Biobehav Rev. 2009 Mar;33(3):475-91
19146872
Pain. 2000 Aug;87(2):113-119
10924804
Forsch Komplementmed. 2008 Jun;15(3):138-45
18617745
Neurology. 2004 Aug 24;63(4):693-701
15326245
PLoS One. 2008;3(10):e3396
18923647
Brain. 2007 Oct;130(Pt 10):2671-87
17575278
Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13848-53
16945915
J Neurosci. 2009 May 13;29(19):6167-75
19439594
Neurosci Lett. 2001 Feb 16;299(1-2):57-60
11166937
Neuroimage. 2009 May 15;46(1):177-92
19233293
Neuroimage. 2009 Apr 15;45(3):940-9
19159691
Annu Rev Neurosci. 1984;7:309-38
6143527
Brain. 2008 Jul;131(Pt 7):1854-79
18567621
Anesthesiology. 2007 Mar;106(3):548-56
17325514
Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7705-9
10393884
Neuron. 2007 Aug 2;55(3):377-91
17678852
Pain. 2005 Oct;117(3):247-250
16154699
J Neurophysiol. 2007 May;97(5):3651-9
17314240
J Neurosci. 2003 Aug 27;23(21):7897-903
12944520
J Orofac Pain. 2000 Summer;14(3):169-84; discussion 184-95
11203754
Lancet. 1999 Oct 9;354(9186):1248-52
10520633
Curr Opin Neurol. 2009 Aug;22(4):331-9
19512925
Eur J Pain. 2005 Aug;9(4):463-84
15979027
Clin Pharmacol Ther. 2008 Apr;83(4):577-88
18030306
Neuroimage. 2007;37 Suppl 1:S80-8
17512757
Proc Natl Acad Sci U S A. 2009 Feb 17;106(7):2423-8
19171885
Pain Res Manag. 2006 Winter;11(4):225-33
17149455
Mol Pain. 2006 Sep 18;2:30
16982005
Neurology. 1992 Mar;42(3 Suppl 2):37-42
1557190
Arthritis Rheum. 2008 Dec;58(12):3960-9
19035484
Pain. 2000 Dec 15;89(1):7-18
11113288
Prog Neurobiol. 2009 Feb;87(2):81-97
18952143
Science. 1991 Mar 15;251(4999):1355-8
2003220
Brain. 2009 Mar;132(Pt 3):788-800
19153154
Hum Brain Mapp. 2009 Apr;30(4):1087-99
18465749
J Neurosci. 2002 Sep 15;22(18):8183-92
12223572
Ann N Y Acad Sci. 2009 Mar;1156:198-210
19338509
J Cell Mol Med. 2009 Aug;13(8B):1605-1619
19228264
Science. 2003 Feb 21;299(5610):1240-3
12595695
AJNR Am J Neuroradiol. 2008 Apr;29(4):632-41
18339720
J Rehabil Med. 2003 May;(41 Suppl):66-72
12817660
Arthritis Rheum. 2008 Mar;58(3):903-7
18311814
J Gend Specif Med. 2002 May-Jun;5(3):37-45
12078061
Curr Opin Neurol. 2007 Aug;20(4):424-31
17620877
Anesth Analg. 2006 Sep;103(3):729-37
16931688
J Neurophysiol. 2004 Jun;91(6):2723-33
15136603
PLoS One. 2009;4(2):e4542
19229326
J Am Board Fam Med. 2009 Jan-Feb;22(1):62-8
19124635
Pain. 2008 Jan;134(1-2):69-79
17504729
Pain. 2005 Dec 15;119(1-3):65-74
16298065
Int J Hyperthermia. 1993 Sep-Oct;9(5):745-54
8245584
Neurol Sci. 2007 May;28 Suppl 2:S101-7
17508154
Pain Med. 2007 Nov-Dec;8(8):624-32
18028040
Pain. 2006 Mar;121(1-2):133-44
16473462
J Neurosci. 2008 Feb 6;28(6):1398-403
18256259
Clin Radiol. 2009 Jan;64(1):12-21
19070693
Curr Opin Neurol. 2008 Aug;21(4):446-51
18607205
Nature. 1995 Jun 8;375(6531):482-4
7777055
Curr Opin Neurol. 2009 Aug;22(4):348-55
19491678
Acta Neurol Scand. 2000 Apr;101(4):262-9
10770524
Pain Med. 2015 Dec;16(12):2368-85
26745152
Eur J Neurosci. 2007 Sep;26(5):1344-56
17767511
Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2465-70
17267613
Expert Rev Neurother. 2009 May;9(5):723-44
19402781