title: Spermatogonial stem cell regulation and spermatogenesis.
abstract: This article will provide an updated review of spermatogonial stem cells and their role in maintaining the spermatogenic lineage. Experimental tools used to study spermatogonial stem cells (SSCs) will be described, along with research using these tools to enhance our understanding of stem cell biology and spermatogenesis. Increased knowledge about the biology of SSCs improves our capacity to manipulate these cells for practical application. The chapter concludes with a discussion of future directions for fundamental investigation and practical applications of SSCs.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, Magee-Womens Research Institute, University of Pittsburgh School of Medicine, 204 Craft Avenue, Pittsburgh, PA, USA.
authors.forename: Bart T
authors.initials: BT
authors.lastname: Phillips
authors.forename: Kathrin
authors.initials: K
authors.lastname: Gassei
authors.forename: Kyle E
authors.initials: KE
authors.lastname: Orwig
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D048708:Cell Growth Processes / Q000502:physiology; D019070:Cell Lineage / Q000502:physiology; D006801:Humans; D008297:Male; D013091:Spermatogenesis / Q000502:physiology*; D013093:Spermatogonia / Q000166:cytology / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology / Q000502:physiology*
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