title: No evidence for a polyomavirus association or aetiology in AIDS-associated nonsmall cell lung cancer.
abstract: AIDS-associated lung cancer has an increasing incidence, unaccounted for by smoking, and occurs consistently at a younger age than matched controls. We investigated whether known and new cancer-associated polyomaviruses, including the newly identified Merkel cell virus, may play a role in its etiopathogenesis. Although viruses target conserved pathways in cellular evolution, we are unable to suggest that the viruses studied here induce novel mechanisms of oncogenic dysregulation in AIDS-associated lung cancer.
authors.affiliation: Department of Oncology, Imperial College School of Medicine, Hammersmith Hospital, London, UK. j.stebbing@imperial.ac.uk
authors.forename: Justin
authors.initials: J
authors.lastname: Stebbing
authors.forename: Colin
authors.initials: C
authors.lastname: Wickenden
authors.forename: Leandro
authors.initials: L
authors.lastname: Castellano
authors.forename: Ailsa
authors.initials: A
authors.lastname: Sita-Lumsden
authors.forename: Mark
authors.initials: M
authors.lastname: Nelson
authors.forename: Jimmy
authors.initials: J
authors.lastname: Jacob
authors.forename: Kikeri
authors.initials: K
authors.lastname: Naresh
authors.forename: Francesco
authors.initials: F
authors.lastname: Mauri
authors.forename: Mark
authors.initials: M
authors.lastname: Bower
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000209:etiology* / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D027601:Polyomavirus Infections / Q000150:complications* / Q000821:virology; D014412:Tumor Virus Infections / Q000150:complications / Q000821:virology