Contagious period for pandemic (H1N1) 2009.
We estimated the proportion of persons with pandemic (H1N1) 2009 who were shedding infectious virus at diagnosis and on day 8 of illness. In households with confirmed cases, nasopharyngeal swabs were collected on all members and tested by PCR and virus culture. Of 47 cases confirmed by PCR at &lt7 days of illness, virus culture was positive in 92% (11/12) of febrile and 63% (22/35) of afebrile persons. Of 43 persons with PCR-confirmed pandemic (H1N1) 2009 from whom a second specimen was collected on day 8, 74% remained PCR positive and 19% were culture positive. If the 73 symptomatic household members without PCR-confirmed illness are assumed to have pandemic (H1N1) 2009, a minimum of 8% (6/73) of case-patients shed replicating virus on day 8. Self-isolation only until fever abates appears insufficient to limit transmission. Self-isolation for a week may be more effective, although some case-patients still would shed infectious virus.
De Serres
Gaston
G
Institut National de Sante Publique du Quebec, Quebec City, Quebec, Canada.
Rouleau
Isabelle
I
Hamelin
Marie Eve
ME
Quach
Caroline
C
Skowronski
Danuta
D
Flamand
Louis
L
Boulianne
Nicole
N
Li
Yan
Y
Carbonneau
Julie
J
Bourgault
Annemarie
A
Couillard
Michel
M
Charest
Hugues
H
Boivin
Guy
G
D000293:Adolescent; D000328:Adult; D002648:Child; D004196:Disease Outbreaks; D005260:Female; D005334:Fever / Q000821:virology; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics / Q000302:isolation & purification*; D007251:Influenza, Human / Q000453:epidemiology / Q000503:physiopathology / Q000635:transmission* / Q000821:virology*; D008297:Male; D009305:Nasopharynx / Q000821:virology; D010356:Patient Isolation; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D013997:Time Factors; D014776:Virus Cultivation; D017201:Virus Shedding
D012367:RNA, Viral
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