Biomaterials in cell microencapsulation.
The field of cell encapsulation is advancing rapidly. This cell-based technology permits the local and long-term delivery ofa desired therapeutic product reducing or even avoiding the need ofimmunosuppressant drugs. The choice of a suitable material preserving the viability and functionality of enclosed cells becomes fundamental if a therapeutic aim is intended. Alginate, which is by far the most frequently used biomaterial in the field of cell microencapsulation, has been demonstrated to be probably the best polymer for this purpose due to its biocompatibility, easy manipulation, gel forming capacity and in vivo performance.
Santos
Edorta
E
Laboratory of Pharmacy and Pharmaceutical Technology, University of the Basque Country, Vitoria, Gasteiz, Spain.
Zarate
Jon
J
Orive
Gorka
G
Hernández
Rosa M
RM
Pedraz
José Luis
JL
D000464:Alginates / Q000737:chemistry / Q000378:metabolism; D001672:Biocompatible Materials / Q000737:chemistry / Q000378:metabolism; D002477:Cells; D004339:Drug Compounding; D016503:Drug Delivery Systems; D006801:Humans; D020100:Hydrogels; D007249:Inflammation / Q000276:immunology; D015394:Molecular Structure; D011108:Polymers / Q000737:chemistry / Q000378:metabolism; D016062:Porosity; D013499:Surface Properties
D000464:Alginates; D001672:Biocompatible Materials; D020100:Hydrogels; D011108:Polymers