Salivary biosensors for screening trauma-related psychopathology.
After facial trauma, a distinct subset of patients goes on to develop mental health problems including recalcitrant psychopathology. Early identification of maladaptive stress reactions provides opportunities for initiating preemptive mental health interventions and hinges on the surgeon's ability to differentiate between transient distress and precursors of recalcitrant psychiatric sequelae. The comprehensive care of injured patients will benefit greatly from objective adjuncts and decision-making tools to complement the clinical evaluation. This article addresses meeting the need for practical, standardized, and reliable screening strategies through promising developments in the use of stress response biomarkers and biosensing technology. The systematic interrogation of differentially expressed stress response biomarkers in saliva now permits rapid assessment of the psychopathogical response to the stressor. Quantitative, point-of-use measurements of the traumatic stress response will greatly improve the nosology of posttraumatic stress disorders and help advance the screening, diagnosis, treatment, and prevention of mental health consequences of violence and trauma.
Shetty
Vivek
V
Section of Oral and Maxillofacial Surgery, 23-009 UCLA School of Dentistry, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095-1668, USA. vshetty@ucla.edu <vshetty@ucla.edu>
Yamaguchi
Masaki
M
D015415:Biomarkers / Q000032:analysis*; D015374:Biosensing Techniques / Q000295:instrumentation*; D005151:Facial Injuries / Q000150:complications*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008403:Mass Screening / Q000379:methods; D001523:Mental Disorders / Q000175:diagnosis* / Q000209:etiology; D010913:Pituitary-Adrenal System / Q000502:physiology; D019095:Point-of-Care Systems; D012463:Saliva / Q000737:chemistry*; D012815:Signal Processing, Computer-Assisted; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis / Q000209:etiology; D013312:Stress, Physiological / Q000502:physiology
D015415:Biomarkers
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