title: Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms.
abstract: The HE4 protein is overexpressed in ovarian carcinomas and can be detected in serum by an ELISA with sensitivity similar to CA125 and higher specificity for malignant disease. We now demonstrate that HE4 can also be detected in the urine at a specificity level of 94.4%, including 13/15 (86.6%) with stage I/II and 57/64 (89.0%) with stage III/IV disease and including 90.5% of patients with serous ovarian carcinoma. Assaying serum and urine from the same patients showed similar sensitivity. Our data indicate that measuring HE4 in urine may aid diagnosis and the monitoring of response to therapy.
authors.affiliation: Department of Pathology, University of Washington, Seattle, WA 98104, USA. ihellstr@u.washington.edu
authors.forename: Ingegerd
authors.initials: I
authors.lastname: Hellstrom
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Heagerty
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Swisher
authors.forename: Pu
authors.initials: P
authors.lastname: Liu
authors.forename: Jade
authors.initials: J
authors.lastname: Jaffar
authors.forename: Kathy
authors.initials: K
authors.lastname: Agnew
authors.forename: Karl Erik
authors.initials: KE
authors.lastname: Hellstrom
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood / Q000652:urine; D004797:Enzyme-Linked Immunosorbent Assay; D030501:Epididymal Secretory Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005831:Genital Diseases, Female / Q000097:blood / Q000235:genetics / Q000652:urine; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood / Q000235:genetics* / Q000652:urine; D017698:Postmenopause; D017697:Premenopause; D012016:Reference Values; D023083:beta-Defensins
chemical_list: D015415:Biomarkers; C426184:DEFB126 protein, human; D030501:Epididymal Secretory Proteins; D023083:beta-Defensins; D003404:Creatinine
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