title: Ovarian yolk sac tumor associated with major fibrosarcoma component in a 13-year-old girl.
abstract: We are presenting a case of a 13-year-old girl with a chief complaint of lower abdominal pain. A computed tomographic scan showed a 10-cm right ovarian mass. The serologic testing showed high alpha-fetoprotein level. The patient underwent a right adnexectomy and an omentectomy. The final diagnosis was a yolk sac tumor with a major (95%) fibrosarcoma component, based on morphology and further confirmed by an extensive panel of immunohistochemistry. Postoperatively, the alpha-fetoprotein level dropped to normal. The patient completed 7 cycles of multiagent chemotherapy with cisplatin without major complications. At her 7-month follow-up, the patient still remains disease free. To our knowledge, our case is the first of its kind in the literature to document yolk sac tumor associated with fibrosarcoma in a teenage female. Owing to the rarity of this entity, the prognosis of this patient is widely unknown and it is yet still to be seen.
authors.affiliation: Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
authors.forename: Liaqat
authors.initials: L
authors.lastname: Ali
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Bambach
authors.forename: Rafal
authors.initials: R
authors.lastname: Kozielski
authors.forename: Heidi
authors.initials: H
authors.lastname: Wagner
authors.forename: Shashikant
authors.initials: S
authors.lastname: Lele
authors.forename: Paulette
authors.initials: P
authors.lastname: Mhawech-Fauceglia
mesh_terms: D000293:Adolescent; D018240:Endodermal Sinus Tumor / Q000473:pathology* / Q000601:surgery; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology* / Q000601:surgery; D006651:Histocytochemistry; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins