title: Chronic changes in the rabbit tibial plateau following blunt trauma to the tibiofemoral joint.
abstract: The knee is often a site of injury that can often lead to a chronic disease known as osteoarthritis (OA). The disease may be initiated, in part, by acute injuries to joint cartilage and its cells. In a recent study by this laboratory, using Flemish Giant rabbits, an impact compressive load on the tibial femoral joint was shown to cause significant levels of acute damage to chondrocytes in cartilage of the medial and lateral tibial plateaus. In the current study, using the same model, histological and mechanical data from the plateaus were documented at 6 and 12 months post impact, and compared to the unimpacted control limbs and a limb from unimpacted, control animals. The mechanical properties of cartilage were measured with indentation relaxation tests on the medial and lateral plateaus in regions covered and uncovered by the meniscus. The histological studies on impacted limbs showed surface lesions on both plateaus, thickening of the underlying subchondral bone at 12 months and numerous occult microcracks at the calcified cartilage-subchondral bone interface at 6 and 12 months, without significant changes in cartilage thickness or its mechanical properties versus controls. Yet, there was an increase in both the matrix and fiber moduli and a decrease in the permeability of uncovered, medial plateau cartilage in both limbs of impacted animals between 6 and 12 months post impact that was not documented in control animals.
authors.affiliation: Orthopaedic Biomechanics Laboratories, College of Osteopathic Medicine, Michigan State University, A407 East Fee Hall, East Lansing, Michigan 48824, East Lansing, MI 48824, USA.
authors.forename: Daniel I
authors.initials: DI
authors.lastname: Isaac
authors.forename: Eric G
authors.initials: EG
authors.lastname: Meyer
authors.forename: Kaitlyn S
authors.initials: KS
authors.lastname: Kopke
authors.forename: Roger C
authors.initials: RC
authors.lastname: Haut
mesh_terms: D000818:Animals; D002358:Cartilage, Articular / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D055119:Elastic Modulus; D005269:Femur / Q000293:injuries / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D011817:Rabbits; D013977:Tibia / Q000293:injuries* / Q000473:pathology / Q000503:physiopathology*; D014949:Wounds, Nonpenetrating / Q000473:pathology / Q000503:physiopathology*