Understanding the development and function of T follicular helper cells.
A fundamental function of T helper (Th) cells is to regulate B-cell proliferation and immunoglobulin class switching, especially in the germinal centers. Th1 and Th2 lineages of CD4(+) T cells have long been considered to play an essential role in helping B cells by promoting the production immunoglobulin G2a (IgG2a) and IgG1/IgE, respectively. Recently, it has become clear that a subset CD4(+) T cells, named T follicular helper (Tfh) cells, is critical to B-cell response induction. In this review, we summarize the latest advances in our understanding of the regulation of Tfh cell differentiation, the relationship of Tfh cells to other CD4(+) T-cell lineages, and the role of Tfh cells in health and disease.
Nurieva
Roza I
RI
Department of Immunology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. rnurieva@mdanderson.org
Chung
Yeonseok
Y
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D002450:Cell Communication; D002454:Cell Differentiation; D019070:Cell Lineage; D006801:Humans; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology* / Q000276:immunology*
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