Vesicular traffic: a Rab SANDwich.
The small GTPases Rab5 and Rab7 mark temporally distinct but sequentially connected stages in phagosome maturation, but the mechanism underlying the transition between these stages has been unclear. Recent studies in Caenorhabditis elegans have now uncovered a new protein complex that connects Rab5 to Rab7.
Bohdanowicz
Michal
M
Cell Biology Program, Hospital for Sick Children and Institute of Medical Science, University of Toronto, Toronto, Canada.
Grinstein
Sergio
S
D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology; D029742:Caenorhabditis elegans Proteins / Q000737:chemistry / Q000502:physiology*; D022162:Cytoplasmic Vesicles / Q000502:physiology; D008954:Models, Biological; D046912:Multiprotein Complexes; D010587:Phagocytosis / Q000502:physiology; D020691:rab GTP-Binding Proteins / Q000737:chemistry / Q000502:physiology*; D020696:rab5 GTP-Binding Proteins / Q000737:chemistry / Q000502:physiology; D000090802:rab7 GTP-Binding Proteins
D029742:Caenorhabditis elegans Proteins; D046912:Multiprotein Complexes; D000090802:rab7 GTP-Binding Proteins; D020691:rab GTP-Binding Proteins; D020696:rab5 GTP-Binding Proteins