In vitro activity of the aminoglycoside antibiotic arbekacin against Acinetobacter baumannii-calcoaceticus isolated from war-wounded patients at Walter Reed Army Medical Center.
We determined the in vitro MIC of arbekacin against 200 Acinetobacter isolates recovered from wounded soldiers. The median MIC was 2 microg/ml (range, 0.5 to > 64 microg/ml). A total of 97.5% of the isolates had arbekacin MICs of < 8 microg/ml and 86.5% had MICs of < or = 4 microg/ml. There was no association between the arbekacin MIC and susceptibility to 16 other antibiotics or the specimen source (P = 0.7239). Synergy testing suggested an enhanced effect of arbekacin-carbapenem combinations.
Zapor
Michael J
MJ
Infectious Disease Service, Walter Reed Army Medical Center, 6900 Georgia Ave., Washington, DC 20307, USA. michael.zapor@us.army.mil
Barber
Melissa
M
Summers
Amy
A
Miller
George H
GH
Feeney
Lee Ann
LA
Eberly
Lynn E
LE
Wortmann
Glenn
G
D040981:Acinetobacter baumannii / Q000187:drug effects* / Q000302:isolation & purification; D000617:Aminoglycosides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology; D003982:Dibekacin / Q000031:analogs & derivatives / Q000494:pharmacology; D006772:Hospitals, Military; D006801:Humans; D008826:Microbial Sensitivity Tests; D014857:Warfare
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D015780:Carbapenems; D003982:Dibekacin; C031986:arbekacin
Clin Infect Dis. 2009 Jun 15;48(12):1724-8
19438394
Antimicrob Agents Chemother. 2000 Sep;44(9):2545-6
10952613
Infect Control Hosp Epidemiol. 2008 Jul;29(7):661-3
18593337
Braz J Infect Dis. 2001 Jun;5(3):130-5
11506776
J Korean Med Sci. 2006 Apr;21(2):188-92
16614499
Antimicrob Agents Chemother. 1999 Apr;43(4):727-37
10103173
J Antimicrob Chemother. 1996 Aug;38(2):287-91
8877544
Cold Spring Harb Symp Quant Biol. 1983;47 Pt 1:189-95
6222863
J Trauma. 2008 Feb;64(2):295-9
18301189
J Antimicrob Chemother. 1992 Dec;30(6):871-2
1289363
Clin Infect Dis. 1997 Jan;24 Suppl 1:S46-62
8994779
Antimicrob Agents Chemother. 1980 Feb;17(2):184-7
7387140
Antimicrob Agents Chemother. 2006 Nov;50(11):3763-9
17065622
Clin Infect Dis. 2007 Jan 1;44(1):79-86
17143821