Effect of interleukin-1beta on the behavior of rats during mild stress in the open-field test.
We studied the effect of interleukin-1beta on the behavior of rats with different individual typological characteristics during mild stress in the open-field test. Intraperitoneal injection of interleukin-1beta (5 microg/kg, 108 U/mg) was followed by a decrease in orientation and exploratory activity of passive and, particularly, of active animals in the open field. As differentiated from rats receiving physiological saline, the initial differences in behavioral characteristics of active and passive animals were not revealed in the repeated test after injection of interleukin-1beta. We conclude that interleukin-1beta abolishes the behavioral differences between active and passive specimens in the open field. These data suggest that administration of interleukin-1beta to rats leads to reorganization of the mechanisms for emotional evaluation of adverse emotiogenic factors under conditions of mild stress in the open-field test.
Pertsov
S S
SS
P K Anokhin Institute of Normal Physiology, Russian Academy of Medical Sciences, Federal State Unitary Enterprise, State Research Institute of Highly Pure Biopreparations, Federal Medical and Biological Agency of Russia, St Petersburg, Russia. s.pertsov@mail.ru
Koplik
E V
EV
Simbirtsev
A S
AS
Kalinichenko
L S
LS
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D004644:Emotions / Q000502:physiology; D005106:Exploratory Behavior / Q000187:drug effects* / Q000502:physiology; D053583:Interleukin-1beta / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological
D053583:Interleukin-1beta