Potent inhibition of protein tyrosine phosphatase 1B by copper complexes: implications for copper toxicity in biological systems.
A new dinuclear copper complex and several Cu-amino acid complexes inhibit protein tyrosine phosphatase 1B competitively at submicromolar levels, suggesting that copper complexes may interfere with cellular signaling pathways by inhibiting protein tyrosine phosphatases.
Wang
Qingming
Q
Institute of Molecular Science, Key Laboratory of Chemical Biology and Molecular Engineering of the Education Ministry, Shanxi University, Taiyuan, Shanxi 030006, PR China.
Lu
Liping
L
Yuan
Caixia
C
Pei
Kai
K
Liu
Zhiwei
Z
Guo
Maolin
M
Zhu
Miaoli
M
D000596:Amino Acids / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects*
D000596:Amino Acids; D009942:Organometallic Compounds; D003300:Copper; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1