The phosphoinositide-3 kinase survival signaling mechanism in sepsis.
Phosphoinositide-3 kinases (PI3Ks) are critical regulatory proteins in the immunologic defense system against sepsis. The PI3K mechanism helps modulate cellular survival, innate and adaptive immunities, inflammation, nuclear factor-κB transcription, and may, in turn, play a protective role in sepsis. Animal studies confirm its role in the prevention of organ dysfunction and improvement of survival outcomes. Further advances in the understanding of this key immunomodulatory pathway may provide valuable insights into the manipulation of cellular function for therapeutic treatment of sepsis and other inflammatory diseases.
Manukyan
Mariuxi C
MC
Clarian Cardiovascular Surgery, Methodist Hospital, Indianapolis, Indiana, USA.
Weil
Brent R
BR
Wang
Yue
Y
Abarbanell
Aaron M
AM
Herrmann
Jeremy L
JL
Poynter
Jeffrey A
JA
Meldrum
Daniel R
DR
D056704:Adaptive Immunity; D000818:Animals; D002470:Cell Survival; D004789:Enzyme Activation; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000201:enzymology; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009102:Multiple Organ Failure / Q000201:enzymology / Q000209:etiology / Q000517:prevention & control; D016328:NF-kappa B / Q000502:physiology; D010538:Peritonitis / Q000201:enzymology / Q000276:immunology / Q000503:physiopathology; D019869:Phosphatidylinositol 3-Kinases / Q000276:immunology / Q000502:physiology*; D020033:Protein Isoforms / Q000502:physiology; D011494:Protein Kinases / Q000502:physiology; D051057:Proto-Oncogene Proteins c-akt / Q000502:physiology; D018805:Sepsis / Q000150:complications / Q000201:enzymology* / Q000276:immunology / Q000503:physiopathology; D015398:Signal Transduction / Q000502:physiology
D016328:NF-kappa B; D020033:Protein Isoforms; D011494:Protein Kinases; D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt