Regulation of membrane biogenesis in autophagy via PI3P dynamics.
In autophagy, cytoplasmic substrates are targeted for degradation in the lysosome via membrane structures called autophagosomes. The formation of the autophagosome is the primary regulatory point for autophagy activity, and PI3P plays a central role in this process. In this review, we will discuss the role of PI3P in autophagosome formation from three different perspectives: PI3-kinase, PI3-binding proteins, and PI3-phosphatase. Recent developments in this field suggest that the local PI3P concentration is dynamically regulated during autophagy, and that this molecule is critical to the proper control of autophagy.
Noda
Takeshi
T
Department of Cellular Regulation, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka, Japan. takenoda@biken.osaka-u.ac.jp
Matsunaga
Kohichi
K
Taguchi-Atarashi
Naoko
N
Yoshimori
Tamotsu
T
D000818:Animals; D001343:Autophagy; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism*; D010588:Phagosomes / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism
D018129:Phosphatidylinositol Phosphates; D019869:Phosphatidylinositol 3-Kinases; D010744:Phosphoric Monoester Hydrolases