Logic implementations using a single nanoparticle-protein hybrid.
A Set-Reset machine is the simplest logic circuit with a built-in memory. Its output is a (nonlinear) function of the input and of the state stored in the machine's memory. Here, we report a nanoscale Set-Reset machine operating at room temperature that is based on a 5-nm silicon nanoparticle attached to the inner pore of a stable circular protein. The nanoparticle-protein hybrid can also function as a balanced ternary multiplier. Conductive atomic force microscopy is used to implement the logic input and output operations, and the processing of the logic Set and Reset operations relies on the finite capacitance of the nanoparticle provided by the good electrical isolation given by the protein, thus enabling stability of the logic device states. We show that the machine can be cycled, such that in every successive cycle, the previous state in the memory is retained as the present state. The energy cost of one cycle of computation is minimized to the cost of charging this state.
Medalsy
Izhar
I
Department of Physical Chemistry and Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Klein
Michael
M
Heyman
Arnon
A
Shoseyov
Oded
O
Remacle
F
F
Levine
R D
RD
Porath
Danny
D
D039301:Computers, Molecular; D018625:Microscopy, Atomic Force; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D011506:Proteins / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry; D055672:Static Electricity
D011506:Proteins; D012825:Silicon
Nano Lett. 2007 Apr;7(4):981-6
17352504
Langmuir. 2009 May 5;25(9):5226-9
19397358
Acta Crystallogr D Biol Crystallogr. 2003 Mar;59(Pt 3):512-4
12595711
Rev Sci Instrum. 2007 Jan;78(1):013705
17503926
Plant Physiol. 2002 Oct;130(2):865-75
12376651
Proc Natl Acad Sci U S A. 2005 Apr 19;102(16):5653-8
15821028
Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):8484-7
12070346
Biotechnol Bioeng. 2006 Sep 5;95(1):161-8
16732592
Angew Chem Int Ed Engl. 2009;48(49):9290-4
19774580
J Biol Chem. 2004 Dec 3;279(49):51516-23
15371455
Nano Lett. 2008 Feb;8(2):473-7
18193911