title: Synthesis and evaluation of a series of C5'-substituted duocarmycin SA analogs.
abstract: The synthesis and evaluation of a key series of analogs of duocarmycin SA, bearing a single substituent at the C5' position of the DNA binding subunit, are described.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors.forename: William M
authors.initials: WM
authors.lastname: Robertson
authors.forename: David B
authors.initials: DB
authors.lastname: Kastrinsky
authors.forename: Inkyu
authors.initials: I
authors.lastname: Hwang
authors.forename: Dale L
authors.initials: DL
authors.lastname: Boger
mesh_terms: D000477:Alkylating Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D000818:Animals; D045744:Cell Line, Tumor; D004247:DNA / Q000737:chemistry; D000080890:Duocarmycins; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D000477:Alkylating Agents; D000080890:Duocarmycins; D007211:Indoles; D011758:Pyrroles; C066098:duocarmycin SA; D004247:DNA
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