Deconstructing ERK signaling in tumorigenesis.
Ras proteins play important protumorigenic roles by activating multiple signaling pathways. A study in this issue of Molecular Cell (Shin et al., 2010) dissects the implications of ERK2 signaling downstream of oncogenic Ras in the induction of epithelial-to-mesenchymal transition (EMT), cell motility, and invasion.
Santamaria
Patricia G
PG
CNIO (Spanish National Cancer Centre), Melchor Fernandez Almagro 3, 28029 Madrid, Spain.
Nebreda
Angel R
AR
D002454:Cell Differentiation / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D004789:Enzyme Activation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020935:MAP Kinase Signaling System / Q000502:physiology*; D019950:Mitogen-Activated Protein Kinase 1 / Q000235:genetics / Q000378:metabolism*; D048052:Mitogen-Activated Protein Kinase 3 / Q000235:genetics / Q000378:metabolism*; D009369:Neoplasms / Q000378:metabolism* / Q000503:physiopathology; D018631:ras Proteins / Q000235:genetics / Q000378:metabolism*
D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D018631:ras Proteins