Antibacterial metabolites from Australian macrofungi from the genus Cortinarius.
In this study, ethyl acetate and aqueous fractions from 117 collections of Australian macrofungi belonging to the mushroom genus Cortinarius were screened for antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa. Overall, the lipophilic fractions were more active than the aqueous fractions. The ethyl acetate fractions of most or all collections of 13 species, namely Cortinarius ardesiacus, C. archeri, C. austrosaginus, C. austrovenetus, C. austroviolaceus, C. coelopus, C. [Dermocybe canaria](2), C. clelandii, C. [D. kula], C. memoria-annae, C. persplendidus, C. sinapicolor, C. vinosipes and forty seven collections of un-described Cortinarius species exhibited IC(50) values of 0.09 mg/mL against S. aureus. In contrast, most or all collections of only four species, namely C. abnormis, C. austroalbidus, C. [D. kula], C. persplendidus, and eleven un-described Cortinarius collections exhibited similar effects against P. aeruginosa (IC(50) <or= 0.09 mg/mL). Anthraquinonoid pigments isolated from C. basirubescens together with emodin physcion and erythrogluacin were assessed for their antimicrobial activity. The fungal octaketides austrocortilutein, austrocortirubin, torosachrysone, physcion and emodin were found to strongly inhibit the growth of S. aureus (IC(50) 0.7-12 microg/mL) whereas only physcion and emodin exhibited potency against P. aeruginosa (IC(50) 1.5 and 2.0 microg/mL, respectively).
Beattie
Karren D
KD
School of Pharmacy, Griffith University, Gold Coast Campus, QLD, Australia. K.Beattie@griffith.edu.au
Rouf
Razina
R
Gander
Louisa
L
May
Tom W
TW
Ratkowsky
David
D
Donner
Christopher D
CD
Gill
Melvyn
M
Grice
I Darren
ID
Tiralongo
Evelin
E
D000880:Anthraquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001315:Australia; D055363:Cortinarius / Q000737:chemistry* / Q000145:classification / Q000235:genetics; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010860:Pigments, Biological / Q000737:chemistry / Q000302:isolation & purification*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D000880:Anthraquinones; D000900:Anti-Bacterial Agents; D010860:Pigments, Biological