Highly efficient diastereoselective reduction of alpha-fluoroimines.
A highly selective reduction of alpha-fluoroimines to the corresponding beta-fluoroamines has been developed utilizing trichlorosilane as the reductant. The key aspect of this reaction is the ability of fluorine and nitrogen to activate organosilanes leading to high diastereoselectivity (>100:1) in the product distribution. This new method provides a new avenue for the diastereoselective synthesis of beta-fluorinated amines in good yields and selectivity.
Malamakal
Roy M
RM
Department of Chemistry, Idaho State University, Campus Box 8023, Pocatello, Idaho 83209, USA.
Hess
Whitney R
WR
Davis
Todd A
TA
D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D007097:Imines
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