title: [Usefulness CT-guided F.N.A.C. in the diagnosis of mediastinal lesions].
abstract: OBJECTIVE
  To evaluate the diagnostic accuracy of the percutaneous fine needle aspiration cytology (FNAC) for mediastinal lesions by using histology or follow-up clinical diagnosis as gold standard.
  
  
  METHODS
  CT-guided percutaneous FNAC was performed on 131 patients with mediastinal lesions. Helical CT was used with 3-10 mm image thickness range and low radiation dose (40 mAs, 120 kV). Samples were immediately examined by a cytologist to determine if they were representative. Histological samples were obtained by means of biopsy or resection specimens in 73 patients and clinical follow-up in 50.
  
  
  RESULTS
  The material was satisfactory for diagnosis in 126 patients (95.2 %), in whom 103 lesions (78.6%) were considered malignant (62 primary tumours and 41 metastases) and 23 (17.6%) benign. In the 123 patients with clinical monitoring or pathological diagnosis, using FNAC led to the identification of malignancy with a sensitivity of 95.2 % (95%CI: 89.2-97.9%), specificity 84.2% (95%CI: 62.4-94.5%), positive predictive value 97.1% (95%-CI: 91.7-99.0%), negative predictive value 76.2% (95%CI: 54.9-89.4%), likelihood-ratio positive 6.03 (95%CI: 2.13-17.05) and accuracy 93.5% (95%CI: 87.7-96.7%). Pneumothorax was the most frequent complication (3 cases). There was good agreement between the cytological findings and the histological findings, not only for malignant lesions (kappa coefficient: 0.641) but also for benign (kappa 0.607).
  
  
  CONCLUSIONS
  CT-guided percutaneous FNAC is a safe and effective technique for the diagnosis of the mediastinal masses, with a high diagnostic yield for malignancy depicting.
authors.affiliation: Servicios de Radiología, Hospital Universitario La Paz, Madrid, España. virpedue@gmail.com
authors.forename: Virginia
authors.initials: V
authors.lastname: Pérez Dueñas
authors.forename: Isabel
authors.initials: I
authors.lastname: Torres Sánchez
authors.forename: Francisco
authors.initials: F
authors.lastname: García Río
authors.forename: Emilio
authors.initials: E
authors.lastname: Valbuena Durán
authors.forename: Blanca
authors.initials: B
authors.lastname: Vicandi Plaza
authors.forename: Jose María
authors.initials: JM
authors.lastname: Viguer García-Moreno
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044963:Biopsy, Fine-Needle / Q000379:methods*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D008875:Middle Aged; D015641:Radiography, Interventional; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed; D055815:Young Adult