title: Chemokines and hepatocellular carcinoma.
abstract: Chemokines play a paramount role in tumor progression. In hepatocellular carcinoma (HCC) progression, chemokines and their receptors play an intricate role. Currently, chemokines and their receptors such as the CXCL12-CXCR4 axis, CX3CL1-CX3CR1 axis and the CCL20-CCR6 axis have received much research attention. Although a large number of studies show that these axes are strongly associated with HCC, the exact mechanism by which these axes promote the growth and progression of HCC remains unknown. In this paper, several chemokines and their receptor interactions in HCC progression, growth and metastasis and immune response to HCC are reviewed.
authors.affiliation: Department of Hepatobiliary Surgery of the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
authors.forename: Fan
authors.initials: F
authors.lastname: Huang
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Geng
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D054418:Chemokine CCL20 / Q000378:metabolism; D054377:Chemokine CXCL12 / Q000378:metabolism; D018925:Chemokines / Q000378:metabolism*; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007107:Immune System; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D008954:Models, Biological; D009362:Neoplasm Metastasis; D054399:Receptors, CCR6 / Q000378:metabolism; D019718:Receptors, CXCR4 / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; C108355:CCL20 protein, human; C106311:CCR6 protein, human; C515255:CXCL12 protein, human; C527276:CXCR4 protein, human; D054418:Chemokine CCL20; D054377:Chemokine CXCL12; D018925:Chemokines; D054399:Receptors, CCR6; D019718:Receptors, CXCR4
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