[Erythropoiesis-stimulating properties of an antiserotonin drug under cytostatic treatment conditions].
Effect of the antiserotonin drug cyproheptadine on the erythropoiesis has been studied under conditions of the administration of cytostatics (fluoropyrimidine antimetabolite 5-fluorouracil (5-FU), alkylating agent cyclophosphane) with different mechanisms of action. It is established that the antiserotonin drug significantly accelerates regeneration of the erythroid hemopoietic branch, especially in the case of 5-FU. The depression of erythron under the conditions of cyclophosphane injections was retained. The erythropoiesis-stimulating effect of cyproheptadine is based on the restoration of the structural and functional organization of the bone marrow (formation of erythroid hemopoietic islets).
Skurikhin
E G
EG
Pershina
O V
OV
Ermakova
N N
NN
Andreeva
T V
TV
Khmelevskaia
E S
ES
Borsuk
O S
OS
Dygaĭ
A M
AM
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000633:toxicity*; D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D003520:Cyclophosphamide / Q000633:toxicity; D003533:Cyproheptadine / Q000494:pharmacology*; D015672:Erythroid Precursor Cells / Q000166:cytology / Q000187:drug effects; D004920:Erythropoiesis / Q000187:drug effects*; D005472:Fluorouracil / Q000633:toxicity; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012702:Serotonin Antagonists / Q000494:pharmacology*
D000964:Antimetabolites, Antineoplastic; D018906:Antineoplastic Agents, Alkylating; D012702:Serotonin Antagonists; D003533:Cyproheptadine; D003520:Cyclophosphamide; D005472:Fluorouracil