A novel profluorescent probe for detecting oxidative stress induced by metal and H(2)O(2) in living cells.
A profluorescent probe that has no fluorescent response to H(2)O(2), iron or copper ions but can be readily activated in the presence of both H(2)O(2) and Fe (or Cu) ion has been developed; the probe is capable of detecting oxidative stress promoted by Fe (or Cu) and H(2)O(2) (i.e. the Fenton reaction conditions) in living cells.
Wei
Yibin
Y
Department of Chemistry and Biochemistry, University of Massachusetts, Dartmouth, MA 02747, USA.
Zhang
Yi
Y
Liu
Zhiwei
Z
Guo
Maolin
M
D045744:Cell Line, Tumor; D002470:Cell Survival; D003300:Copper / Q000494:pharmacology*; D005456:Fluorescent Dyes / Q000032:analysis* / Q000138:chemical synthesis / Q000737:chemistry; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D007501:Iron / Q000494:pharmacology*; D015394:Molecular Structure; D009447:Neuroblastoma / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D013237:Stereoisomerism
D005456:Fluorescent Dyes; D003300:Copper; D006861:Hydrogen Peroxide; D007501:Iron
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