title: [Morphological changes in esophageal mucosa in children with overweight].
abstract: In present work we studied the morphological features of the esophageal mucosa in 63 children with endoscopic diagnosis of the distal esophagitis having overweight and normal weight of a body. The biopsies were taken at level of 3 cm above a Z-line and at level of 1 cm above a Z-line. Dystrophic and dysregenerative changes were revealed at the majority of children and half of children had inflammatory changes of the esophageal mucosa regardless of weight of a body. These changes are more pronounced at level of 1 cm above a Z-line, their occurrence decreases with a distance from low esophageal sphincter. We used the pathology score system for assess the esophageal biopsies. According our scale we obtained following results: at level of 1 cm above Z-lines at 95% of children had the normal, minimum or mild features of esophagitis regardless of weight of a body. Morphological evidence of a reflux esophagitis was diagnosed statistically more often at level of 1 cm above Z lines in comparison with level of 3 cm above Z-lines (p < 0.01) as among children with overweight of the body (78 and 43% accordingly), and among children with normal weight of the body (78 and 35% accordingly). The obtained data will be allowed to avoid hyperdiagnostics of esophageal lesions in children.
authors.forename: M I
authors.initials: MI
authors.lastname: Dubrovskaia
authors.forename: A S
authors.initials: AS
authors.lastname: Tertychnyĭ
authors.forename: Iu G
authors.initials: IuG
authors.lastname: Mukhina
authors.forename: I I
authors.initials: II
authors.lastname: Volodina
authors.forename: S I
authors.initials: SI
authors.lastname: Mamchenko
mesh_terms: D000293:Adolescent; D002648:Child; D004941:Esophagitis / Q000150:complications / Q000473:pathology*; D004947:Esophagus / Q000473:pathology*; D005764:Gastroesophageal Reflux / Q000209:etiology* / Q000473:pathology; D006801:Humans; D009092:Mucous Membrane / Q000473:pathology; D050177:Overweight / Q000150:complications / Q000473:pathology*