Comparative study of potential endothelioprotectors and impaza in modeled nitric oxide deficiency.
Experimental NO deficiency induced by L-NAME injection led to the development of arterial hypertension, endothelial dysfunction, and cardiomyocyte hypertrophy and reduced blood content of nitrates and nitrites. Impaza, NO donors, activators of NO-synthase, antioxidants, and antihypertensive preparations produced endothelium-protective effect of different degree.
Pokrovskii
M V
MV
Kursk State Medical University, Federal Agency for Health Care and Social Development.
Kochkarov
V I
VI
Pokrovskaya
T G
TG
Artyushkova
E B
EB
Pashin
E N
EN
Danilenko
L M
LM
Korokin
M V
MV
Belous
A S
AS
Korokina
L V
LV
Malykhin
V A
VA
Zaloznykh
Ya I
YI
Brusnik
M S
MS
Zhavbert
E S
ES
D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D004730:Endothelium, Vascular / Q000187:drug effects*; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009566:Nitrates / Q000378:metabolism; D009569:Nitric Oxide / Q000172:deficiency*; D020030:Nitric Oxide Donors / Q000627:therapeutic use; D009573:Nitrites / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use
D000906:Antibodies; D000959:Antihypertensive Agents; D000975:Antioxidants; C534505:IMPAZA; D009566:Nitrates; D020030:Nitric Oxide Donors; D009573:Nitrites; D013267:Stilbenes; D009569:Nitric Oxide; D000077185:Resveratrol; D019331:NG-Nitroarginine Methyl Ester