Statistical contributions to proteomic research.
Proteomic profiling has the potential to impact the diagnosis, prognosis, and treatment of various diseases. A number of different proteomic technologies are available that allow us to look at many proteins at once, and all of them yield complex data that raise significant quantitative challenges. Inadequate attention to these quantitative issues can prevent these studies from achieving their desired goals, and can even lead to invalid results. In this chapter, we describe various ways the involvement of statisticians or other quantitative scientists in the study team can contribute to the success of proteomic research, and we outline some of the key statistical principles that should guide the experimental design and analysis of such studies.
Morris
Jeffrey S
JS
Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
Baggerly
Keith A
KA
Gutstein
Howard B
HB
Coombes
Kevin R
KR
D015415:Biomarkers / Q000652:urine; D005260:Female; D006801:Humans; D007834:Lasers; D009369:Neoplasms / Q000378:metabolism / Q000652:urine; D040901:Proteomics / Q000706:statistics & numerical data*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D015415:Biomarkers
Cancer Res. 2004 Aug 15;64(16):5882-90
15313933
Endocr Relat Cancer. 2004 Jun;11(2):163-78
15163296
Brief Funct Genomic Proteomic. 2005 Feb;3(4):322-31
15814023
Bioinformatics. 2004 Mar 22;20(5):777-85
14751995
Endocr Relat Cancer. 2004 Dec;11(4):583-4; author reply 585-7
15613439
Proteomics. 2003 Sep;3(9):1667-72
12973722
Lancet. 2002 Feb 16;359(9306):572-7
11867112
Biostatistics. 2004 Apr;5(2):155-76
15054023
Cancer Inform. 2005;1:9-14
19305627
Cancer Inform. 2007 Feb 23;2:313-27
19458774
J Natl Cancer Inst. 2005 Feb 16;97(4):307-9
15713966
Bioinformatics. 2008 Feb 15;24(4):529-36
18194961
J Natl Cancer Inst. 2004 Mar 3;96(5):353-6
14996856
Mol Cell Proteomics. 2004 Apr;3(4):367-78
14990683
Bioinformatics. 2004 Jul 22;20(11):1737-45
14988112
BMC Bioinformatics. 2003 Jun 9;4:24
12795817
Bioinformatics. 2003 Jul 1;19(10):1236-42
12835267
Bioinformatics. 2007 Jan 15;23(2):264-5
17121773
Nat Biotechnol. 2005 Mar;23(3):291-2
15765078
Nat Rev Cancer. 2004 Apr;4(4):309-14
15057290
J Natl Cancer Inst. 2007 Jan 17;99(2):147-57
17227998
Clin Chem. 2003 Oct;49(10):1615-23
14500586
Bioinformatics. 2005 May 1;21(9):1764-75
15673564
Expert Rev Mol Diagn. 2004 Sep;4(5):575-7
15347249
Proteomics. 2005 Nov;5(16):4107-17
16254928