title: Maturation of auditory temporal integration and inhibition assessed with event-related potentials (ERPs).
abstract: BACKGROUND
  We examined development of auditory temporal integration and inhibition by assessing electrophysiological responses to tone pairs separated by interstimulus intervals (ISIs) of 25, 50, 100, 200, 400, and 800 ms in 28 children aged 7 to 9 years, and 15 adults.
  
  
  RESULTS
  In adults a distinct neural response was elicited to tones presented at ISIs of 25 ms or longer, whereas in children this was only seen in response to tones presented at ISIs above 100 ms. In adults, late N1 amplitude was larger for the second tone of the tone pair when separated by ISIs as short as 100 ms, consistent with the perceptual integration of successive stimuli within the temporal window of integration. In contrast, children showed enhanced negativity only when tone pairs were separated by ISIs of 200 ms. In children, the amplitude of the P1 component was attenuated at ISIs below 200 ms, consistent with a refractory process.
  
  
  CONCLUSIONS
  These results indicate that adults integrate sequential auditory information into smaller temporal segments than children. These results suggest that there are marked maturational changes from childhood to adulthood in the perceptual processes underpinning the grouping of incoming auditory sensory information, and that electrophysiological measures provide a sensitive, non-invasive method allowing further examination of these changes.
authors.affiliation: School of Psychology, University of Western Australia, Perth, Australia. allison.fox@uwa.edu.au.
authors.forename: Allison M
authors.initials: AM
authors.lastname: Fox
authors.forename: Mike
authors.initials: M
authors.lastname: Anderson
authors.forename: Corinne
authors.initials: C
authors.lastname: Reid
authors.forename: Tim
authors.initials: T
authors.lastname: Smith
authors.forename: Dorothy V M
authors.initials: DV
authors.lastname: Bishop
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000375:Aging / Q000502:physiology*; D001303:Auditory Cortex / Q000254:growth & development*; D001306:Auditory Pathways / Q000254:growth & development; D001307:Auditory Perception / Q000502:physiology*; D001309:Auditory Threshold / Q000502:physiology; D002648:Child; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009433:Neural Inhibition / Q000502:physiology; D009483:Neuropsychological Tests; D010470:Perceptual Masking / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D013017:Sound Localization / Q000502:physiology*; D013997:Time Factors; D013998:Time Perception / Q000502:physiology*; D055815:Young Adult
references.citation: Clin Neurophysiol. 2005 Aug;116(8):1747-53
references.pmid: 16000258
references.citation: J Speech Lang Hear Res. 2006 Oct;49(5):1104-13
references.pmid: 17077218
references.citation: Psychophysiology. 1997 Jan;34(1):32-8
references.pmid: 9009806
references.citation: Clin Neurophysiol. 2005 Jul;116(7):1695-706
references.pmid: 15905124
references.citation: PLoS One. 2008;3(12):e3929
references.pmid: 19081790
references.citation: Psychophysiology. 1991 Mar;28(2):240-4
references.pmid: 1946890
references.citation: Psychophysiology. 2004 Jul;41(4):636-42
references.pmid: 15189486
references.citation: J Speech Lang Hear Res. 2000 Dec;43(6):1402-15
references.pmid: 11193961
references.citation: J Cogn Neurosci. 2006 Jan;18(1):1-13
references.pmid: 16417678
references.citation: Cortex. 2005 Jun;41(3):327-41
references.pmid: 15871598
references.citation: Acta Otolaryngol. 2003 Jan;123(2):249-52
references.pmid: 12701751
references.citation: Clin Neurophysiol. 2005 Sep;116(9):2184-203
references.pmid: 16043399
references.citation: Psychophysiology. 1998 Jul;35(4):470-8
references.pmid: 9643062
references.citation: J Acoust Soc Am. 2003 May;113(5):2790-800
references.pmid: 12765396
references.citation: Int J Pediatr Otorhinolaryngol. 2008 Sep;72(9):1317-22
references.pmid: 18584882
references.citation: Dyslexia. 2003 Feb;9(1):37-45
references.pmid: 12625375
references.citation: Clin Neurophysiol. 2003 Dec;114(12):2307-25
references.pmid: 14652090
references.citation: Clin Neurophysiol. 2002 Mar;113(3):407-20
references.pmid: 11897541
references.citation: Psychophysiology. 1993 Jan;30(1):98-119
references.pmid: 8416067
references.citation: Psychophysiology. 2000 Mar;37(2):127-52
references.pmid: 10731765
references.citation: J Acoust Soc Am. 1995 Nov;98(5 Pt 1):2532-41
references.pmid: 7593935
references.citation: Psychophysiology. 1986 Nov;23(6):695-703
references.pmid: 3823345
references.citation: Brain Res. 2006 Dec 8;1124(1):126-41
references.pmid: 17069776
references.citation: Psychophysiology. 1987 Jul;24(4):375-425
references.pmid: 3615753
references.citation: Cereb Cortex. 2009 Oct;19(10):2290-7
references.pmid: 19136454
references.citation: Electroencephalogr Clin Neurophysiol Suppl. 1995;44:102-9
references.pmid: 7649012
references.citation: Clin Neurophysiol. 2000 Mar;111(3):388-97
references.pmid: 10699397
references.citation: Psychophysiology. 1997 May;34(3):308-16
references.pmid: 9175445
references.citation: Electroencephalogr Clin Neurophysiol. 1998 Jul;108(4):345-54
references.pmid: 9714376
references.citation: Clin Neurophysiol. 2000 Dec;111(12):2268-76
references.pmid: 11090781
references.citation: Child Dev. 1985 Jun;56(3):614-20
references.pmid: 4006570
references.citation: Electroencephalogr Clin Neurophysiol. 1996 May;100(3):220-8
references.pmid: 8681863
references.citation: Dev Sci. 2004 Sep;7(4):F11-8
references.pmid: 15484585
references.citation: Hear Res. 2008 Feb;236(1-2):61-79
references.pmid: 18207681
references.citation: Ear Hear. 2007 Dec;28(6):862-78
references.pmid: 17982372
references.citation: Psychophysiology. 2005 Nov;42(6):668-76
references.pmid: 16364062
references.citation: Nat Rev Neurosci. 2004 Nov;5(11):887-92
references.pmid: 15496866
references.citation: Psychophysiology. 1987 Jul;24(4):479-86
references.pmid: 3615759
references.citation: Neuropsychologia. 2009 Feb;47(3):771-85
references.pmid: 19124031
references.citation: J Speech Lang Hear Res. 2008 Aug;51(4):1002-15
references.pmid: 18658067