title: Influence of aging on the sleep rebound induced by immobilization stress in the rat.
abstract: It is now known that after an immobilization stress (IS) of short duration (1h), adult rats exhibit a significant rapid eye movement (REM) sleep rebound. In this study, we examined this phenomenon in aged animals. We found that aged rats subjected to an IS did not show a sleep rebound after the restraint, in contrast to younger animals. Plasma corticosterone and corticotrophin (ACTH(1)(-)(39)) levels were, however, similar in aged and adult rats. The corticotrophin-like intermediate lobe peptide (CLIP or ACTH(18)(-)(39)) system of the arcuate nucleus, suggested to be involved in REM sleep genesis by way of pontine projections (HP: the hypothalamo-pontine axis), was also not different between aged and young rats. The lack of REM sleep rebound observed in aged animals is thus independent of the HPA (hypothalamo-pituitary-adrenal) and HP axe activities. The causal impairments might reside in REM sleep executive structures of the dorsal pontine tegmentum.
authors.affiliation: EA 4170, Claude, Bernard University Lyon1, Faculty of Medicine, 8 Avenue Rockefeller, 69373 Lyon Cedex 08, France. amandine.lefebvre@sante.univ-lyon1.fr
authors.forename: Amandine
authors.initials: A
authors.lastname: Descamps
authors.forename: Raymond
authors.initials: R
authors.lastname: Cespuglio
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000378:metabolism; D000375:Aging / Q000502:physiology*; D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000378:metabolism; D053497:Corticotropin-Like Intermediate Lobe Peptide / Q000097:blood / Q000378:metabolism; D004195:Disease Models, Animal; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism / Q000503:physiopathology*; D007103:Immobilization / Q000502:physiology; D009434:Neural Pathways / Q000378:metabolism / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D012893:Sleep Wake Disorders / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology*; D012895:Sleep, REM / Q000502:physiology; D013315:Stress, Psychological / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*
chemical_list: D053497:Corticotropin-Like Intermediate Lobe Peptide; D000324:Adrenocorticotropic Hormone; D003345:Corticosterone