Effects of 900-MHz microwave radiation on gamma-ray-induced damage to mouse hematopoietic system.
Exposure of humans simultaneously to microwave and gamma-ray irradiation may be a commonly encountered phenomenon. In a previous study data showed that low-dose microwave radiation increased the survival rate of mice irradiated with 8Gy gamma-ray; however, the mechanisms underlying these findings remain unclear. Consequently, studies were undertaken to examine the effects of microwave exposure on hematopoietic system adversely altered by gamma-ray irradiation in mice. Preexposure to low-dose microwaves attenuated the damage produced by gamma-ray irradiation as evidenced by less severe pathological alterations in bone marrow and spleen. The protective effects of microwaves were postulated to be due to up-expression of some hematopoietic growth factors, stimulation of proliferation of the granulocyte-macrophages in bone marrow, and inhibition of the gamma-ray induced suppression of hematopoietic stem cells/hematopoietic progenitor cells. Data thus indicate that prior exposure to microwaves may be beneficial in providing protection against injuries produced by gamma-ray on the hematopoietic system in mice.
Cao
Yi
Y
School of Radiation Medicine and Public Health, Suzhou University, Suzhou, China.
Xu
Qian
Q
Jin
Zong-Da
ZD
Zhang
Jun
J
Lu
Min-Xia
MX
Nie
Ji-Hua
JH
Tong
Jian
J
D000818:Animals; D049109:Cell Proliferation / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays / Q000009:adverse effects*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood; D055014:Granulocyte-Macrophage Progenitor Cells / Q000528:radiation effects; D006413:Hematopoietic System / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D007377:Interleukin-3 / Q000378:metabolism; D008297:Male; D051379:Mice; D008872:Microwaves / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy*; D011835:Radiation Protection; D013154:Spleen / Q000473:pathology / Q000528:radiation effects
D007377:Interleukin-3; D016178:Granulocyte-Macrophage Colony-Stimulating Factor