Organocatalytic asymmetric intramolecular [3+2] cycloaddition: a straightforward approach to access multiply substituted hexahydrochromeno[4,3-b]pyrrolidine derivatives in high optical purity.
A chiral phosphoric acid-catalyzed intramolecular 1,3-dipolar cycloaddition of 4-(2-formylphenoxy)butenoates with amino esters provides hexahydromeno[4,3-b]pyrrolidine derivatives in high enantioselectivity (up to 94% ee).
Li
Nan
N
Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041.
Song
Jin
J
Tu
Xi-Feng
XF
Liu
Bin
B
Chen
Xiao-Hua
XH
Gong
Liu-Zhu
LZ
D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010756:Phosphoric Acids / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D010756:Phosphoric Acids; D011759:Pyrrolidines; C030242:phosphoric acid