Hypophysectomy and neurointermediate pituitary lobectomy decrease humoral immune responses to T-independent and T-dependent antigens.
In rats, hypophysectomy (HYPOX) or neurointermediate pituitary lobectomy (NIL) reduce humoral and cell-mediated immune responses. However, to our knowledge, the differences in the effects of anterior versus posterior pituitary hormones on the immune responses have not been studied to date. We compared in rats, the effects of sham surgery (SHAM), HYPOX, and NIL on humoral immune responses to T cell-independent (TI) type 1 antigen DNP-LPS and to TI type 2 antigen DNP-FICOLL, as well as to T cell-dependent (TD) antigens ovalbumin (OVA) and bovine serum albumin (BSA). The results showed that: (1) both HYPOX and NIL induced a similar and significant decrease in IgM responses towards TI-1 antigens, (2) NIL but not HYPOX induced a decreased IgM response to TI-2 antigens, and (3) both HYPOX and NIL induced similar and significant decrease in IgG responses to TI-2 antigens. Compared with the SHAM group, IgM responses to both TD antigens did not change in HYPOX and NIL animals, whereas the IgG responses to OVA and BSA significantly decreased in HYPOX and NIL animals. These results indicate that hormones of the anterior and posterior pituitary play their own role in the regulation of humoral immune responses.
Quintanar-Stephano
A
A
Departamento de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, México.
Abarca-Rojano
E
E
Jarillo-Luna
R A
RA
Rivera-Aguilar
V
V
Ventura-Juárez
J
J
Berczi
I
I
Kovacs
K
K
Campos-Rodríguez
R
R
D000818:Animals; D000955:Antigens, T-Independent / Q000276:immunology*; D007016:Hypophysectomy; D056724:Immunity, Humoral; D007074:Immunoglobulin G / Q000276:immunology / Q000378:metabolism; D007075:Immunoglobulin M / Q000276:immunology / Q000378:metabolism; D008297:Male; D010047:Ovalbumin / Q000276:immunology; D010902:Pituitary Gland / Q000276:immunology* / Q000601:surgery; D051381:Rats; D012710:Serum Albumin, Bovine / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000955:Antigens, T-Independent; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012710:Serum Albumin, Bovine; D010047:Ovalbumin
Brain Behav Immun. 2007 May;21(4):384-92
17198749
Int J Immunopharmacol. 1992 Jan;14(1):93-103
1533854
N Engl J Med. 1995 May 18;332(20):1351-62
7715646
Adv Exp Med Biol. 1998;449:1-13
10026781
Ann N Y Acad Sci. 2000;917:825-34
11268412
Neuroimmunomodulation. 2004;11(4):233-40
15249729
Neuroendocrinology. 1993 Jul;58(1):106-10
8264843
Ann N Y Acad Sci. 1997 Aug 14;823:214-24
9292047
Immunol Rev. 2000 Aug;176:154-70
11043775
Chem Immunol. 1997;69:155-84
9353965
J Neuroimmunol. 2003 Feb;135(1-2):72-81
12576226
J Immunol. 1975 Feb;114(2 Pt 1):704-9
1079035
Life Sci. 1993;52(1):95-105
8417282
Front Neuroendocrinol. 1993 Apr;14(2):76-122
8387436
Endocrinology. 1990 May;126(5):2703-10
2158433
Annu Rev Immunol. 2002;20:125-63
11861600
Proc Soc Exp Biol Med. 1991 Oct;198(1):513-27
1891468
J Immunol. 1975 Jan;114(1 Pt 2):360-4
1090653
Br J Rheumatol. 1998 Feb;37(2):131-6
9569066
J Immunol. 1988 Apr 1;140(7):2179-83
2965181
J Endocrinol. 2005 Jan;184(1):51-8
15642782
Infect Immun. 2006 Mar;74(3):1883-9
16495563
Mol Endocrinol. 2004 Nov;18(11):2777-89
15284336
Annu Rev Immunol. 1998;16:111-35
9597126