A general and straightforward method for the synthesis of 2-trifluoromethylbenzothiazoles.
An efficient one-pot method for the synthesis of 2-trifluoromethylbenzothiazoles by the treatment of trifluoromethylimidoyl chlorides with sodium hydrosulfide hydrate using PdCl(2) as the sole catalyst in DMSO is described. The reaction proceeds via thiolation/C-H bond functionalization/C-S bond formation in moderate to high yields with good functional group tolerance.
Zhu
Jiangtao
J
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China.
Chen
Zixian
Z
Xie
Haibo
H
Li
Shan
S
Wu
Yongming
Y
D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013440:Sulfides / Q000737:chemistry*
D052160:Benzothiazoles; D006845:Hydrocarbons, Fluorinated; D013440:Sulfides; C025451:sodium bisulfide