title: Progress in siRNA delivery using multifunctional nanoparticles.
abstract: Nanoparticles made from synthetic polymers have been developed to deliver small interfering RNA (siRNA). For successful siRNA delivery, these nanoparticles need to efficiently encapsulate siRNA, actively target sites of interest, and release siRNA intracellularly. This chapter reviews recent progress using a multifunctional approach to design and engineer polymeric nanoparticles for siRNA delivery.
authors.affiliation: Laboratory of Nanomedicine and Biomaterials, Department of Anesthesia, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Weiwei
authors.initials: W
authors.lastname: Gao
authors.forename: Zeyu
authors.initials: Z
authors.lastname: Xiao
authors.forename: Alex
authors.initials: A
authors.lastname: Radovic-Moreno
authors.forename: Jinjun
authors.initials: J
authors.lastname: Shi
authors.forename: Robert
authors.initials: R
authors.lastname: Langer
authors.forename: Omid C
authors.initials: OC
authors.lastname: Farokhzad
mesh_terms: D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D018014:Gene Transfer Techniques / Q000639:trends*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000378:metabolism*
chemical_list: D034741:RNA, Small Interfering