High-resolution BOLD fMRI measurements of local orientation-dependent contextual modulation show a mismatch between predicted V1 output and local BOLD response.
The blood oxygenation level-dependent (BOLD) functional MRI response to suppressive neural activity has not been tested on a fine spatial scale. Using Gabor patches placed in the near periphery, we precisely localized individual regions of interest in primary visual cortex and measured the response at a range of contrasts in two different contexts: with parallel and with orthogonal flanking Gabor patches. Psychophysical measurements confirmed strong suppression of the target Gabor response when flanked by parallel Gabors. However, the BOLD response to the target with parallel flankers decreased as the target contrast increased, which contradicts psychophysical estimates of local neural activity.
Schumacher
Jennifer F
JF
Department of Neuroscience, University of Minnesota, N-218 Elliott Hall, 75 East River Parkway, Minneapolis, MN 55455, USA. schum204@umn.edu
Olman
Cheryl A
CA
D000328:Adult; D015350:Contrast Sensitivity / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010775:Photic Stimulation; D011601:Psychophysics; D012684:Sensory Thresholds; D014793:Visual Cortex / Q000502:physiology*; D055815:Young Adult
Biophys J. 1993 Mar;64(3):803-12
8386018
J Neurosci. 2003 May 15;23(10):3963-71
12764080
Neuroimage. 2010 Feb 1;49(3):1965-76
19800408
J Neurophysiol. 2001 Sep;86(3):1398-411
11535686
Spat Vis. 1997;10(4):433-6
9176952
Nature. 1998 Feb 5;391(6667):580-4
9468134
Magn Reson Med. 1993 Aug;30(2):161-73
8366797
J Neurophysiol. 2009 Sep;102(3):1930-44
19587316
Magn Reson Med. 2005 Dec;54(6):1465-72
16276507
J Cereb Blood Flow Metab. 2001 Oct;21(10):1133-45
11598490
Science. 1995 May 12;268(5212):889-93
7754376
J Comp Neurol. 2000 May 29;421(2):161-71
10813779
J Neurosci. 1984 Jan;4(1):251-64
6693941
J Neurosci. 2003 Jul 30;23(17):6884-93
12890783
Neuroimage. 2007 Mar;35(1):149-65
17234435
Hum Brain Mapp. 2008 Sep;29(9):1001-14
18381768
Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):14114-9
19666522
J Neurosci. 2005 Sep 21;25(38):8704-7
16177039
Nature. 2008 Mar 20;452(7185):352-5
18322462
Vision Res. 2001 Dec;41(27):3663-75
11712981
Nat Neurosci. 2007 Dec;10(12):1515-7
17982452
J Neurosci. 2008 Dec 31;28(53):14347-57
19118167
J Neurosci. 2004 Oct 13;24(41):8940-9
15483113
J Neurophysiol. 2009 Nov;102(5):2900-9
19710383
Neuroimage. 2005 Jan 1;24(1):216-23
15588613
J Comp Neurol. 1995 May 22;356(1):115-31
7629306
Magn Reson Med. 2000 May;43(5):705-15
10800036
Cereb Cortex. 1997 Mar;7(2):181-92
9087826
Vision Res. 1999 Jan;39(2):257-69
10326134
Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):16000-5
14673091
Nat Neurosci. 2005 May;8(5):679-85
15852014
Nature. 1998 Aug 20;394(6695):784-7
9723617
J Neurophysiol. 2002 Nov;88(5):2547-56
12424293
J Neurosci. 2006 Sep 6;26(36):9117-29
16957068
J Cereb Blood Flow Metab. 2001 Dec;21(12):1367-83
11740198
J Neurophysiol. 2003 Jan;89(1):525-33
12522199
J Neurosci. 2007 Apr 18;27(16):4452-9
17442830
J Neurosci Res. 2005 Feb 1;79(3):383-91
15619231
Spat Vis. 1997;10(4):437-42
9176953
Vision Res. 2000;40(22):3065-72
10996610
Neuroimage. 2004;23 Suppl 1:S208-19
15501092
Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2382-6
8637882
J Neurophysiol. 2006 Feb;95(2):862-81
16221748
Nature. 1995 Jun 29;375(6534):780-4
7596409
J Comp Neurol. 1993 Aug 1;334(1):19-46
8408757
Neuroimage. 2002 Oct;17(2):825-41
12377157
Neuropharmacology. 1994 Nov;33(11):1453-61
7532829
Nat Neurosci. 2006 Apr;9(4):569-77
16547508
Neuroimage. 2007 Feb 1;34(3):1126-35
17157534
Neuron. 2005 Dec 22;48(6):901-11
16364895
J Neurosci. 2002 Oct 1;22(19):8633-46
12351737
J Physiol. 1998 Oct 15;512 ( Pt 2):555-66
9763643
Cereb Cortex. 2001 Jan;11(1):37-58
11113034
J Neurosci. 1996 Nov 15;16(22):7376-89
8929444
J Neurosci. 1994 May;14(5 Pt 1):2545-68
8182427
Proc Natl Acad Sci U S A. 2005 Apr 12;102(15):5588-93
15809416