Peptide and protein thioester synthesis via N-->S acyl transfer.
Peptide and protein thioesters are playing an increasingly prominent role in the chemical toolbox for protein assembly and modification through Native Chemical Ligation (NCL). In this Emerging Area we highlight recent developments in a somewhat surprising route to thioesters: selective disruption of amides, the more stable carboxylic acid derivatives.
Kang
Jaskiranjit
J
Department of Chemistry, University College London, 20 Gordon Street, London, UK WC1H 0AJ.
Macmillan
Derek
D
D000577:Amides / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
D000577:Amides; D010455:Peptides; D011506:Proteins; D013438:Sulfhydryl Compounds