title: Two new asymmetric sesquiterpene dimers from the rhizomes of Ligularia muliensis.
abstract: Two new asymmetric eremophilane-type sesquiterpene dimers, ligulamulienin A (1) and B (2), were isolated from the rhizomes of Ligularia muliensis. Their structures were determined based on their spectroscopic data, including IR, EI-MS, HR-electrospray ionization (ESI)-MS, 1D and 2D-NMR spectroscopy. The cytotoxicity of compounds 1 and 2 was measured in in vitro human carcinoma (MGC-803), human hepatoma (HEP-G2), and murine sarcoma (S-180) cell lines.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, P R China.
authors.forename: Dong-Qing
authors.initials: DQ
authors.lastname: Fei
authors.forename: Qiu-Hong
authors.initials: QH
authors.lastname: Wu
authors.forename: Shi-Gang
authors.initials: SG
authors.lastname: Li
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019659:Asteraceae / Q000737:chemistry*; D002277:Carcinoma / Q000188:drug therapy; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D027343:Rhizome / Q000737:chemistry; D012509:Sarcoma / Q000188:drug therapy; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes