Bisphenol A in combination with TNF-alpha selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity.
Bisphenol A (BPA) is a monomer used in manufacturing a wide range of chemical products, including epoxy resins and polycarbonate. BPA, an important endocrine disrupting chemical that exerts estrogen-like activities, is detectable at nanomolar levels in human serum worldwide. The pregnancy associated doses of 17beta-estradiol (E2) plus tumor-necrosis factor-alpha (TNF-alpha) induce distorted maturation of human dendritic cells (DCs) that result in an increased capacity to induce T helper (Th) 2 responses. The current study demonstrated that the presence of BPA during DC maturation influences the function of human DCs, thereby polarizing the subsequent Th response. In the presence of TNF-alpha, BPA treatment enhanced the expression of CC chemokine ligand 1 (CCL1) in DCs. In addition, DCs exposed to BPA/TNF-alpha produced higher levels of IL-10 relative to those of IL-12p70 on CD40 ligation, and preferentially induced Th2 deviation. BPA exerts the same effect with E2 at the same dose (0.01-0.1 microM) with regard to DC-mediated Th2 polarization. These findings imply that DCs exposed to BPA will provide one of the initial signals driving the development and perpetuation of Th2-dominated immune response in allergic reactions.
Guo
Hongchuan
H
Department of Neurosurgery, XuanWu Hospital, Capital University of Medical Science, Beijing, China.
Liu
Tianyi
T
Uemura
Yasushi
Y
Jiao
Shunchang
S
Wang
Deqing
D
Lin
Zilin
Z
Narita
Yayoi
Y
Suzuki
Motoharu
M
Hirosawa
Narumi
N
Ichihara
Yasuko
Y
Ishihara
Osamu
O
Kikuchi
Hirosato
H
Sakamoto
Yasushi
Y
Senju
Satoru
S
Zhang
Qiuhang
Q
Ling
Feng
F
D001559:Benzhydryl Compounds; D023201:CD40 Ligand / Q000276:immunology; D002454:Cell Differentiation; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D004967:Estrogens / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis / Q000276:immunology; D018664:Interleukin-12 / Q000096:biosynthesis / Q000276:immunology; D010636:Phenols / Q000276:immunology*; D018418:Th2 Cells / Q000166:cytology / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D023201:CD40 Ligand; D004967:Estrogens; D016753:Interleukin-10; D018664:Interleukin-12; D010636:Phenols; D014409:Tumor Necrosis Factor-alpha; C006780:bisphenol A; D000098826:Bisphenol A Compounds
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