title: MicroRNAs in neural cell differentiation.
abstract: The architecture and functioning of the mammalian nervous system are partly based on the complexity of combinatorial gene expression in the developing brain that results in a tremendous diversity of neural cells. MicroRNAs are small non-coding RNAs that are particularly abundant in the brain and are emerging as influential regulators of neural gene expression. This review summarizes the recently discovered role of microRNAs in the development and maintenance of the nervous system. MicroRNAs are temporally expressed during neural differentiation, spatially regulated and embedded in molecular feedback loops that may contribute to the robustness of the neural networks.
authors.affiliation: Section of Developmental Genetics, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA.
authors.forename: Pierre
authors.initials: P
authors.lastname: Lau
authors.forename: Lynn D
authors.initials: LD
authors.lastname: Hudson
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D055495:Neurogenesis / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*
chemical_list: D035683:MicroRNAs
references.citation: Neuron. 2010 Mar 11;65(5):612-26
references.pmid: 20223198
references.citation: Brain Pathol. 2009 Jul;19(3):375-83
references.pmid: 18624795
references.citation: J Exp Med. 2007 Jul 9;204(7):1553-8
references.pmid: 17606634
references.citation: Nat Rev Mol Cell Biol. 2005 Oct;6(10):777-88
references.pmid: 16314867
references.citation: J Neurosci. 2008 Oct 8;28(41):10415-21
references.pmid: 18842901
references.citation: Nat Struct Mol Biol. 2009 Apr;16(4):365-71
references.pmid: 19330006
references.citation: Nature. 1988 Jun 9;333(6173):560-2
references.pmid: 3287176
references.citation: RNA. 2003 Oct;9(10):1274-81
references.pmid: 13130141
references.citation: Nat Neurosci. 2007 Dec;10(12):1513-4
references.pmid: 17994015
references.citation: Semin Cell Dev Biol. 2010 Sep;21(7):768-73
references.pmid: 20080199
references.citation: Neuron. 2010 Mar 11;65(5):597-611
references.pmid: 20223197
references.citation: Science. 2004 Jan 2;303(5654):56-9
references.pmid: 14704420
references.citation: Nat Neurosci. 2008 Jun;11(6):641-8
references.pmid: 18454145
references.citation: Cell. 1999 Jun 11;97(6):703-16
references.pmid: 10380923
references.citation: Genes Dev. 2007 Apr 1;21(7):744-9
references.pmid: 17403776
references.citation: Nature. 2005 Feb 17;433(7027):769-73
references.pmid: 15685193
references.citation: Genome Biol. 2004;5(3):R13
references.pmid: 15003116
references.citation: Development. 2008 Dec;135(23):3911-21
references.pmid: 18997113
references.citation: J Neurosci. 2008 Dec 31;28(53):14341-6
references.pmid: 19118166
references.citation: J Neurosci. 2008 Apr 23;28(17):4322-30
references.pmid: 18434510
references.citation: Nature. 2004 Jan 1;427(6969):78-83
references.pmid: 14702088
references.citation: RNA. 2006 Feb;12(2):187-91
references.pmid: 16373485
references.citation: J Neurosci. 2008 Nov 5;28(45):11720-30
references.pmid: 18987208
references.citation: Neuron. 2004 Mar 25;41(6):881-90
references.pmid: 15046721
references.citation: Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2422-7
references.pmid: 16461918
references.citation: Nat Neurosci. 2009 Apr;12(4):399-408
references.pmid: 19287386
references.citation: Genome Biol. 2004;5(9):R68
references.pmid: 15345052
references.citation: J Comp Neurol. 2008 May 1;508(1):28-44
references.pmid: 18288691
references.citation: Mol Cell. 2007 Aug 3;27(3):435-48
references.pmid: 17679093
references.citation: Nature. 2009 Jul 30;460(7255):642-6
references.pmid: 19561591
references.citation: Cell Stem Cell. 2007 Nov;1(5):515-28
references.pmid: 18371391
references.citation: Curr Opin Cell Biol. 2009 Jun;21(3):452-60
references.pmid: 19450959
references.citation: Science. 2007 Aug 31;317(5842):1220-4
references.pmid: 17761882
references.citation: Genes Dev. 2007 Jul 1;21(13):1636-52
references.pmid: 17606642
references.citation: Nat Genet. 2003 Sep;35(1):76-83
references.pmid: 12881722
references.citation: BMC Neurosci. 2009 Aug 19;10:98
references.pmid: 19689821
references.citation: Science. 2005 Jan 28;307(5709):596-600
references.pmid: 15681389
references.citation: Biochem Biophys Res Commun. 2002 Nov 29;299(2):328-34
references.pmid: 12437990
references.citation: Curr Opin Cell Biol. 2006 Dec;18(6):704-9
references.pmid: 17046226