[Sclerosing angiomatoid nodular transformation of spleen: a clinicopathologic study of 10 cases with review of literature].
OBJECTIVE
To study the clinicopathologic features, differential diagnosis and pathogenesis of sclerosing angiomatoid nodular transformation of spleen.


METHODS
Ten cases of sclerosing angiomatoid nodular transformation of spleen were retrieved from the archival file. Histochemical and immunohistochemical (EnVision method) studies were performed. Ultrastructural findings were also available in one of them.


RESULTS
Sclerosing angiomatoid nodular transformation was characterized by micronodular appearance of vascular spaces lined by plump endothelial cells with interspersed ovoid spindle cells. Immunohistochemical study showed that the endothelial cells of vessels in the angiomatoid nodules had various expressions of immunologic phenotypes and could be mainly classified into 3 types: CD34(+)/CD31(+)/CD8⁻ endothelial cells of the capillaries, CD8(+)/CD31(+)/CD34⁻ lining cells of the sinusoids and CD31(+)/CD8⁻/CD34⁻ endothelial cells of the small veins. Collagen network and dilated lymphatic sinuses were evident under transmission electron microscope.


CONCLUSIONS
Sclerosing angiomatoid nodular transformation of spleen is a rare benign entity. It may represent a reactive condition and bears some relationship with splenic angioma. It needs to be distinguished from borderline or malignant vascular tumors of spleen.
Hou
Jun
J
Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China. junhoudaily@yahoo.com.cn
Ji
Yuan
Y
Tan
Yun-shan
YS
Shi
Da-ren
DR
Liu
Ya-lan
YL
Xu
Chen
C
Zeng
Hai-ying
HY
D000328:Adult; D018952:Antigens, CD34 / Q000378:metabolism; D016827:CD8 Antigens / Q000378:metabolism; D003937:Diagnosis, Differential; D005260:Female; D006390:Hemangioendothelioma / Q000378:metabolism / Q000473:pathology; D006394:Hemangiosarcoma / Q000378:metabolism / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism; D013160:Splenic Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure
D018952:Antigens, CD34; D016827:CD8 Antigens; D019408:Platelet Endothelial Cell Adhesion Molecule-1