title: Leishmania interferes with host cell signaling to devise a survival strategy.
abstract: The protozoan parasite Leishmania spp. exists as extracellular promastigotes in its vector whereas it resides and replicates as amastigotes within the macrophages of its mammalian host. As a survival strategy, Leishmania modulates macrophage functions directly or indirectly. The direct interference includes prevention of oxidative burst and the effector functions that lead to its elimination. The indirect effects include the antigen presentation and modulation of T cell functions in such a way that the effector T cells help the parasite survive by macrophage deactivation. Most of these direct and indirect effects are regulated by host cell receptor signaling that occurs through cycles of phosphorylation and dephosphorylation in cascades of kinases and phosphatases. This review highlights how Leishmania selectively manipulates the different signaling pathways to ensure its survival.
authors.affiliation: Lab no. 5, National Center for Cell Science, University of Pune, Ganeshkhind, Pune 411 007, India.
authors.forename: Suvercha
authors.initials: S
authors.lastname: Bhardwaj
authors.forename: Neetu
authors.initials: N
authors.lastname: Srivastava
authors.forename: Raki
authors.initials: R
authors.lastname: Sudan
authors.forename: Bhaskar
authors.initials: B
authors.lastname: Saha
mesh_terms: D000818:Animals; D006790:Host-Parasite Interactions / Q000502:physiology; D006801:Humans; D007891:Leishmania / Q000472:pathogenicity / Q000502:physiology*
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