Formation of celecoxib nanoparticles from volatile microemulsions.
A new composition of a fully water-dilutable microemulsion system stabilized by natural surfactants is presented as a template for preparation of celecoxib nanoparticles. Nanoparticles are obtained as a dry powder upon rapid conversion of microemulsion droplets with dissolved celecoxib into nanoparticles, followed by evaporation of all the liquid in a spray dryer. The resultant powder is easily re-dispersible in water to form a clear, transparent dispersion. The celecoxib nanoparticles are amorphous and their average size in the dispersion is 17 nm, in agreement with cryo-TEM results and concentration measurements after filtration. As a result of the nanometric size and amorphous state, about 10-fold increase in dissolution of the powder was obtained, compared to that for particulate celecoxib in the presence of surfactants.
Margulis-Goshen
Katrin
K
Casali Institute of Applied Chemistry, Institute of Chemistry, The Hebrew University of Jerusalem, Jerusalem, Israel.
Kesselman
Ellina
E
Danino
Dganit
D
Magdassi
Shlomo
S
D000085:Acetates / Q000737:chemistry; D000440:Butanols / Q000737:chemistry; D000068579:Celecoxib; D002626:Chemistry, Pharmaceutical; D020285:Cryoelectron Microscopy; D052246:Cyclooxygenase 2 Inhibitors / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D004553:Electric Conductivity; D004655:Emulsions; D019695:Glycyrrhizic Acid / Q000737:chemistry; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry; D011208:Powders; D011720:Pyrazoles / Q000737:chemistry*; D012995:Solubility; D013449:Sulfonamides / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D014835:Volatilization; D014867:Water / Q000737:chemistry
D000085:Acetates; D000440:Butanols; D052246:Cyclooxygenase 2 Inhibitors; D004337:Drug Carriers; D004655:Emulsions; D010713:Phosphatidylcholines; D011208:Powders; D011720:Pyrazoles; D013449:Sulfonamides; D013501:Surface-Active Agents; D014867:Water; C006848:butyl acetate; D019695:Glycyrrhizic Acid; D000068579:Celecoxib