title: Mediators of inflammation in polycystic ovary syndrome in relation to adiposity.
abstract: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women of reproductive age group and is associated with a higher cardiovascular risk. Obesity, mainly visceral adiposity, is prevalent in patients with PCOS. Obesity is associated with low-grade inflammation and raised inflammatory cytokines, both of which are also described in patients with PCOS. In this paper, the potential relationships between fat distribution, adipocyte dysfunction and, altered inflammatory markers in patients with PCOS have been discussed.
authors.affiliation: Academic Endocrinology, Diabetes and Metabolism, Hull York Medical School, Michael White Diabetes Centre, 220-236 Analby Road, Hull Royal Infirmary, Hull HU32JZ, UK. thozhukat.sathyapalan@hyms.ac.uk
authors.forename: Thozhukat
authors.initials: T
authors.lastname: Sathyapalan
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Atkin
mesh_terms: D050154:Adiposity / Q000276:immunology*; D002318:Cardiovascular Diseases / Q000209:etiology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology; D018836:Inflammation Mediators / Q000276:immunology*; D007333:Insulin Resistance; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000276:immunology*
chemical_list: D018836:Inflammation Mediators
references.citation: FASEB J. 2004 Nov;18(14):1657-69
references.pmid: 15522911
references.citation: Immun Ageing. 2005 May 18;2:8
references.pmid: 15904534
references.citation: Jpn J Cancer Res. 2001 Feb;92(2):103-8
references.pmid: 11223538
references.citation: Fertil Steril. 1995 Dec;64(6):1099-103
references.pmid: 7589659
references.citation: Hum Reprod. 2004 Jan;19(1):41-7
references.pmid: 14688154
references.citation: J Clin Endocrinol Metab. 2006 Apr;91(4):1357-63
references.pmid: 16434451
references.citation: J Clin Endocrinol Metab. 2000 Jul;85(7):2434-8
references.pmid: 10902790
references.citation: Circulation. 2007 Feb 27;115(8):1029-38
references.pmid: 17296858
references.citation: Diabetologia. 2003 May;46(5):625-33
references.pmid: 12739017
references.citation: J Clin Endocrinol Metab. 2005 May;90(5):2740-6
references.pmid: 15741256
references.citation: J Clin Endocrinol Metab. 1996 Nov;81(11):4166-9
references.pmid: 8923878
references.citation: J Mol Endocrinol. 1992 Aug;9(1):61-72
references.pmid: 1515026
references.citation: Circulation. 2002 Jul 2;106(1):24-30
references.pmid: 12093765
references.citation: Obstet Gynecol. 2003 Jun;101(6):1177-82
references.pmid: 12798522
references.citation: Obesity (Silver Spring). 2008 Jun;16(6):1248-55
references.pmid: 18421279
references.citation: Eur J Endocrinol. 2004 Apr;150(4):525-32
references.pmid: 15080783
references.citation: J Clin Endocrinol Metab. 2002 Jul;87(7):3287-90
references.pmid: 12107238
references.citation: Fertil Steril. 2002 May;77(5):932-5
references.pmid: 12009346
references.citation: Acta Obstet Gynecol Scand. 1992 Dec;71(8):599-604
references.pmid: 1336918
references.citation: N Engl J Med. 1994 Aug 18;331(7):468-9
references.pmid: 8035844
references.citation: J Clin Endocrinol Metab. 1997 Jun;82(6):1697-700
references.pmid: 9177366
references.citation: Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1304-10
references.pmid: 18420999
references.citation: Hum Reprod. 2003 Sep;18(9):1790-6
references.pmid: 12923129
references.citation: Hum Fertil (Camb). 2000;3(2):101-105
references.pmid: 11844363
references.citation: J Clin Endocrinol Metab. 1997 Dec;82(12):4144-8
references.pmid: 9398729
references.citation: Obstet Gynecol Surv. 2004 Feb;59(2):141-54
references.pmid: 14752302
references.citation: Metabolism. 1999 Apr;48(4):437-41
references.pmid: 10206434
references.citation: Ann N Y Acad Sci. 1993 May 28;687:115-23
references.pmid: 8323166
references.citation: Fertil Steril. 1992 Mar;57(3):505-13
references.pmid: 1740195
references.citation: Int J Obes Relat Metab Disord. 2001 Oct;25(10):1407-15
references.pmid: 11673759
references.citation: Hum Reprod. 1997 Apr;12(4):633-5
references.pmid: 9159414
references.citation: J Clin Endocrinol Metab. 2003 Jun;88(6):2562-8
references.pmid: 12788855
references.citation: J Clin Endocrinol Metab. 1997 Oct;82(10):3408-13
references.pmid: 9329377
references.citation: Hum Reprod. 2001 Jun;16(6):1255-60
references.pmid: 11387301
references.citation: Am J Pathol. 2000 Jan;156(1):7-14
references.pmid: 10623647
references.citation: J Clin Epidemiol. 1998 Jul;51(7):581-6
references.pmid: 9674665
references.citation: Clin Exp Immunol. 2006 Oct;146(1):39-46
references.pmid: 16968396
references.citation: Clin Endocrinol (Oxf). 1994 Aug;41(2):231-6
references.pmid: 7923828
references.citation: Curr Opin Lipidol. 2001 Apr;12(2):167-73
references.pmid: 11264988
references.citation: Diabetes. 2006 Jun;55(6):1554-61
references.pmid: 16731817
references.citation: Diabetes. 1989 Sep;38(9):1165-74
references.pmid: 2670645
references.citation: Diabetes Care. 1999 Jan;22(1):141-6
references.pmid: 10333916
references.citation: Clin Endocrinol (Oxf). 1997 Feb;46(2):175-81
references.pmid: 9135699
references.citation: J Clin Endocrinol Metab. 2004 Jun;89(6):2745-9
references.pmid: 15181052
references.citation: Endocrinology. 1997 Aug;138(8):3374-9
references.pmid: 9231790
references.citation: Science. 1993 Jan 1;259(5091):87-91
references.pmid: 7678183
references.citation: J Clin Endocrinol Metab. 2005 Nov;90(11):6014-21
references.pmid: 16105965
references.citation: J Clin Endocrinol Metab. 1992 Aug;75(2):577-83
references.pmid: 1322430
references.citation: Clin Endocrinol (Oxf). 1996 Nov;45(5):623-9
references.pmid: 8977761
references.citation: Fertil Steril. 1995 May;63(5):1000-4
references.pmid: 7720907
references.citation: Am J Physiol Gastrointest Liver Physiol. 2002 Jan;282(1):G1-5
references.pmid: 11751151
references.citation: Am J Med. 1998 Jun 22;104(6A):18S-27S
references.pmid: 9684848
references.citation: Trends Endocrinol Metab. 2001 Mar;12(2):65-72
references.pmid: 11167124
references.citation: N Engl J Med. 2005 Mar 24;352(12):1223-36
references.pmid: 15788499
references.citation: Immunology. 2009 Feb;126(2):233-45
references.pmid: 18624726
references.citation: Eur J Endocrinol. 2005 Mar;152(3):389-94
references.pmid: 15757855
references.citation: J Clin Endocrinol Metab. 1983 Aug;57(2):356-9
references.pmid: 6223044
references.citation: Am J Phys Anthropol. 2004 Jul;124(3):275-81
references.pmid: 15197822
references.citation: Reprod Biomed Online. 2004 Nov;9(5):505-10
references.pmid: 15588467
references.citation: Clin Endocrinol (Oxf). 2006 Aug;65(2):137-45
references.pmid: 16886951
references.citation: Gynecol Endocrinol. 2003 Jun;17(3):231-7
references.pmid: 12857431
references.citation: J Clin Endocrinol Metab. 2001 Jun;86(6):2453-5
references.pmid: 11397838
references.citation: J Clin Endocrinol Metab. 2005 Jan;90(1):2-5
references.pmid: 15483098
references.citation: Nat Med. 2005 Feb;11(2):191-8
references.pmid: 15685170
references.citation: Endocr Rev. 1997 Dec;18(6):774-800
references.pmid: 9408743
references.citation: Arterioscler Thromb Vasc Biol. 2000 Nov;20(11):2414-21
references.pmid: 11073846
references.citation: J Clin Endocrinol Metab. 2000 Sep;85(9):3338-42
references.pmid: 10999830
references.citation: Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10679-84
references.pmid: 15249654
references.citation: Diabetes Care. 2003 Jun;26(6):1922-6
references.pmid: 12766135
references.citation: J Biol Chem. 2003 Mar 14;278(11):9850-5
references.pmid: 12519759