Role of mesenchymal precursor cells in the stimulation of wound healing under the effect of ultralow doses of antibodies to granulocytic colony-stimulating factor.
On the model of skin flap we studied the possibility of stimulating the processes of wound healing with a preparation containing ultralow doses of antibodies to granulocytic colony-stimulating factor. The preparation accelerated tissue regeneration against the background of mobilization of bone marrow mesenchymal precursor cells into circulation accompanied by an increase in the number of stromal precursor cells in the area of lesion.
Zyuz'kov
G N
GN
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Tomsk.
Zhdanov
V V
VV
Gur'yantseva
L A
LA
Stavrova
L A
LA
Khrichkova
T Yu
TY
Dygai
A M
AM
Goldberg
E D
ED
D000818:Animals; D000906:Antibodies / Q000276:immunology* / Q000627:therapeutic use*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000276:immunology*; D008297:Male; D059630:Mesenchymal Stem Cells / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA; D014945:Wound Healing / Q000187:drug effects*
D000906:Antibodies; D016179:Granulocyte Colony-Stimulating Factor