title: Aortic Customize: an in vivo feasibility study of a percutaneous technique for the repair of aortic aneurysms using injectable elastomer.
abstract: OBJECTIVE
  This study aimed to test a percutaneous technique for aneurysm-sac filling by means of in situ polymerisation in an in vivo model.
  
  
  METHODS
  Aortic Customize is a new endovascular treatment concept for aortic aneurysms: a non-cross-linked liquid elastomer is injected to fill the aneurysm sac around a balloon-catheter. With this method, a compliant elastomer mould with a patent lumen is created.
  
  
  METHODS
  The formulation used in the experiments consisted of a two-component addition-cure liquid-silicone formulation, based on vinyl-terminated polydimethylsiloxane (PDMS).
  
  
  METHODS
  The concept of aneurysm-sac filling was tested in vivo in porcine experiments (n = 3).
  
  
  RESULTS
  In vivo porcine experiments with the sac-filling application showed successful exclusion of the created aneurysms with patent lumens and absence of endoleaks. The aneurysms were excluded successfully in the in vivo model, injecting elastomer through a 7-French catheter, filling up the entire aneurysm sac.
  
  
  CONCLUSIONS
  These in vivo experiments demonstrate that the principle of aneurysm-sac filling by means of in situ curing is feasible, excluding the aneurysm and creating a new lumen. Further long-term animal experiments must be done prior to consideration of clinical application.
authors.affiliation: Department of Surgery, Leiden University Medical Center, Post box 9600, K6-R, 2300 RC Leiden, The Netherlands. w.m.p.f.bosman@lumc.nl
authors.forename: W M P F
authors.initials: WM
authors.lastname: Bosman
authors.forename: J
authors.initials: J
authors.lastname: Vlot
authors.forename: T J
authors.initials: TJ
authors.lastname: van der Steenhoven
authors.forename: O
authors.initials: O
authors.lastname: van den Berg
authors.forename: J F
authors.initials: JF
authors.lastname: Hamming
authors.forename: A C
authors.initials: AC
authors.lastname: de Vries
authors.forename: H L F
authors.initials: HL
authors.lastname: Brom
authors.forename: M J
authors.initials: MJ
authors.lastname: Jacobs
mesh_terms: D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000000981:diagnostic imaging / Q000628:therapy*; D001027:Aortography; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000295:instrumentation* / Q000379:methods*; D002404:Catheterization; D004129:Dimethylpolysiloxanes / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005240:Feasibility Studies; D015552:Injections, Intralesional; D011474:Prosthesis Design; D012826:Silicone Elastomers / Q000008:administration & dosage*; D013552:Swine
chemical_list: D004129:Dimethylpolysiloxanes; D012826:Silicone Elastomers