Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents.
A series of N-alkyl substituted urea derivatives were synthesized and evaluated for their in vitro antibacterial and antifungal activities. The N-alkyl substituted urea derivatives bearing morpholine moiety (3a-3k) showed better activities than those bearing diethylamine moiety (2a-2f). Compounds having fluoro substituent at ortho (3c) and para (3b) positions of the phenyl ring exhibited potent antimicrobial activities against Gram-positive and Gram-negative bacteria as well as fungi.
Zheng
Qing-Zhong
QZ
State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, PR China.
Cheng
Kui
K
Zhang
Xiao-Min
XM
Liu
Kai
K
Jiao
Qing-Cai
QC
Zhu
Hai-Liang
HL
D000473:Alkanes / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D005658:Fungi / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D014508:Urea / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D000473:Alkanes; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D014508:Urea