title: PARP and PARG inhibitors--new therapeutic targets in cancer treatment.
abstract: Today, the number of cancer patients throughout the world is increasing alarmingly and as per the World Health Organisation (WHO) data and statistics the prediction for the year 2020 will be 15 million new cases as compared to only 10 million cases in year 2000 leaving us dumbfounded. A lot of effort has been put in by researchers and scientists over decades to find drugs helpful in the treatment of cancers for the benefit of patients--the latest being the Poly ADP-ribose polymerase (PARP) and the Poly ADP-ribose glycohydrolase (PARG) inhibitors. This review highlights their mechanism of action under the rationale of their use and current development in the field of cancer.
authors.affiliation: Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, China.
authors.forename: Nilufer Jasmine Selimah
authors.initials: NJ
authors.lastname: Fauzee
authors.forename: Juan
authors.initials: J
authors.lastname: Pan
authors.forename: Ya-lan
authors.initials: YL
authors.lastname: Wang
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology*; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D000067856:Poly(ADP-ribose) Polymerase Inhibitors; D011065:Poly(ADP-ribose) Polymerases; D006026:Glycoside Hydrolases; C022407:poly ADP-ribose glycohydrolase
references.citation: Cancer Res. 1998 Nov 15;58(22):5075-8
references.pmid: 9823314
references.citation: BMC Genomics. 2007 Feb 07;8:41
references.pmid: 17286852
references.citation: Pharmacol Rev. 2002 Sep;54(3):375-429
references.pmid: 12223530
references.citation: Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17079-84
references.pmid: 18971340
references.citation: Free Radic Biol Med. 2009 Jul 1;47(1):13-26
references.pmid: 19362586
references.citation: Cancer Sci. 2007 Oct;98(10):1528-35
references.pmid: 17645773
references.citation: Biochem J. 1999 Sep 1;342 ( Pt 2):249-68
references.pmid: 10455009
references.citation: Pharmacology. 2003 Nov;69(3):150-7
references.pmid: 14512702
references.citation: Eur J Biochem. 1980 Feb;104(1):279-87
references.pmid: 6245868
references.citation: Biochem J. 2005 Feb 15;386(Pt 1):119-25
references.pmid: 15456408
references.citation: J Biol Chem. 2002 Jul 26;277(30):26921-6
references.pmid: 12011073
references.citation: Mol Cell Biol. 2001 Mar;21(5):1828-32
references.pmid: 11238919
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2008 Sep 1;872(1-2):141-7
references.pmid: 18692448
references.citation: Clin Cancer Res. 2008 Nov 1;14(21):6877-85
references.pmid: 18980982
references.citation: Oncogene. 2004 May 6;23(21):3872-82
references.pmid: 15021907
references.citation: Am J Physiol. 1999 Sep;277(3):F428-36
references.pmid: 10484526
references.citation: Mol Pharmacol. 2005 Sep;68(3):895-904
references.pmid: 15976037
references.citation: EMBO J. 2008 May 7;27(9):1368-77
references.pmid: 18388863
references.citation: Biochem J. 1995 May 15;308 ( Pt 1):131-7
references.pmid: 7755555
references.citation: J Oncol. 2010;2010:151750
references.pmid: 20049345
references.citation: Am J Pathol. 2003 Jan;162(1):7-10
references.pmid: 12507884
references.citation: Neurol India. 2009 May-Jun;57(3):264-8
references.pmid: 19587465
references.citation: Clin Cancer Res. 2007 May 1;13(9):2728-37
references.pmid: 17473206
references.citation: J Clin Oncol. 2008 Aug 1;26(22):3785-90
references.pmid: 18591545
references.citation: Eur J Cancer. 2007 Sep;43(14):2124-33
references.pmid: 17714938
references.citation: Biochem Biophys Res Commun. 2006 Dec 1;350(4):1056-62
references.pmid: 17046715
references.citation: Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):13978-82
references.pmid: 10570184
references.citation: Br J Pharmacol. 2008 Dec;155(8):1235-49
references.pmid: 18806807
references.citation: J Biochem. 1999 Oct;126(4):748-55
references.pmid: 10502684
references.citation: Cancer Res. 2006 Aug 15;66(16):8109-15
references.pmid: 16912188
references.citation: Proc Natl Acad Sci U S A. 2004 Dec 21;101(51):17699-704
references.pmid: 15591342
references.citation: Exp Cell Res. 1999 Sep 15;251(2):401-13
references.pmid: 10471325
references.citation: Mol Cancer Res. 2008 Oct;6(10):1621-9
references.pmid: 18922977
references.citation: Breast Cancer Res Treat. 1999 Mar;54(1):1-10
references.pmid: 10369075
references.citation: Nat Med. 1999 Mar;5(3):269-70
references.pmid: 10086377
references.citation: N Engl J Med. 2009 Jul 9;361(2):123-34
references.pmid: 19553641
references.citation: Cell. 2003 Jun 13;113(6):677-83
references.pmid: 12809599
references.citation: Semin Oncol. 2002 Dec;29(6 Suppl 16):15-8
references.pmid: 12516034
references.citation: Oncogene. 2002 Feb 7;21(7):1108-16
references.pmid: 11850828
references.citation: Mol Cancer Ther. 2009 Aug;8(8):2243-54
references.pmid: 19671736
references.citation: BMC Mol Biol. 2007 Oct 25;8:96
references.pmid: 17961220
references.citation: Eur J Cancer. 2005 Dec;41(18):2948-57
references.pmid: 16288862
references.citation: Biochem Pharmacol. 2006 Feb 14;71(4):441-52
references.pmid: 16337154
references.citation: Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):82-6
references.pmid: 14676324
references.citation: Mol Cell Biol. 2001 Jun;21(12):4046-54
references.pmid: 11359911
references.citation: Arterioscler Thromb Vasc Biol. 2008 Apr;28(4):711-7
references.pmid: 18239155
references.citation: J Biol Chem. 2009 Dec 4;284(49):33926-38
references.pmid: 19812418
references.citation: Mol Pharmacol. 2003 Jan;63(1):192-202
references.pmid: 12488552
references.citation: Curr Opin Pharmacol. 2005 Aug;5(4):388-93
references.pmid: 15955736
references.citation: Clin Cancer Res. 2008 Dec 1;14(23):7917-23
references.pmid: 19047122
references.citation: J Biol Chem. 1998 Nov 27;273(48):31644-7
references.pmid: 9822623
references.citation: Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13345-50
references.pmid: 10557323
references.citation: J Biol Chem. 2006 Nov 10;281(45):34394-405
references.pmid: 16963444
references.citation: Mutat Res. 2001 Jun 2;477(1-2):111-7
references.pmid: 11376692
references.citation: Intensive Care Med. 2006 Oct;32(10):1649-57
references.pmid: 16927075
references.citation: Clin Cancer Res. 1999 May;5(5):1169-72
references.pmid: 10353753
references.citation: Eur J Cell Biol. 2005 Nov;84(11):885-96
references.pmid: 16323285
references.citation: Nature. 2005 Apr 14;434(7035):913-7
references.pmid: 15829966
references.citation: Brain Res Mol Brain Res. 2003 Oct 7;117(2):213-20
references.pmid: 14559156
references.citation: Gastroenterology. 2005 Jun;128(7):1919-36
references.pmid: 15940627
references.citation: Mol Cell. 2005 Apr 1;18(1):83-96
references.pmid: 15808511
references.citation: FEBS Lett. 1998 Mar 6;424(1-2):27-32
references.pmid: 9537509
references.citation: Biochem Biophys Res Commun. 2006 Nov 17;350(2):352-7
references.pmid: 17007818
references.citation: FASEB J. 2005 Apr;19(6):558-66
references.pmid: 15791006
references.citation: Gene. 2003 Sep 18;314:181-90
references.pmid: 14527731
references.citation: Crit Care Med. 2004 Jun;32(6):1365-74
references.pmid: 15187521
references.citation: Cancer Res. 1997 May 15;57(10):1835-40
references.pmid: 9157970
references.citation: J Biol Chem. 1999 Jul 9;274(28):19792-8
references.pmid: 10391922
references.citation: J Biol Chem. 1992 Jan 25;267(3):1569-75
references.pmid: 1530940
references.citation: Biochem J. 2006 Jun 15;396(3):419-29
references.pmid: 16526943
references.citation: J Biol Chem. 2003 Nov 14;278(46):45145-53
references.pmid: 12960163
references.citation: Mol Cell Biol. 1999 Jan;19(1):296-306
references.pmid: 9858553
references.citation: Int J Mol Med. 2008 Jul;22(1):113-8
references.pmid: 18575783
references.citation: Biochem J. 1980 Mar 1;185(3):775-7
references.pmid: 6248035
references.citation: DNA Repair (Amst). 2008 Dec 1;7(12):2010-9
references.pmid: 18832051
references.citation: Clin Cancer Res. 2007 May 15;13(10):3033-42
references.pmid: 17505006
references.citation: J Biol Chem. 2000 Jul 28;275(30):23234-9
references.pmid: 10930429
references.citation: Jpn J Clin Oncol. 2005 Feb;35(2):97-102
references.pmid: 15709096
references.citation: EMBO J. 2006 Mar 22;25(6):1305-14
references.pmid: 16498404
references.citation: J Biol Chem. 1982 Apr 25;257(8):4027-30
references.pmid: 6175637
references.citation: Cell Growth Differ. 1996 Jan;7(1):91-100
references.pmid: 8788037
references.citation: Genes Dev. 1997 Sep 15;11(18):2347-58
references.pmid: 9308963
references.citation: Oncogene. 1997 Feb 27;14(8):891-8
references.pmid: 9050988
references.citation: Int J Med Sci. 2006 Jul 15;3(4):117-23
references.pmid: 16906222
references.citation: J Biol Chem. 2001 Jan 26;276(4):2935-42
references.pmid: 11053413
references.citation: Oncogene. 1999 Jul 8;18(27):3954-62
references.pmid: 10435618
references.citation: Cancer Lett. 1981 Dec;14(3):227-36
references.pmid: 6277470
references.citation: Ai Zheng. 2007 Jun;26(6):566-71
references.pmid: 17562258
references.citation: Mol Cell Biol. 2004 Aug;24(16):7163-78
references.pmid: 15282315
references.citation: Cancer Res. 1983 Jul;43(7):3441-6
references.pmid: 6406058
references.citation: J Clin Invest. 1978 Jul;62(1):111-8
references.pmid: 659624
references.citation: Int J Biol Sci. 2006;2(4):179-85
references.pmid: 16810332
references.citation: Cell Death Differ. 2009 Feb;16(2):264-77
references.pmid: 18974775
references.citation: J Immunol. 2007 Jul 1;179(1):305-12
references.pmid: 17579050
references.citation: Expert Rev Mol Med. 2005 Mar 15;7(4):1-20
references.pmid: 15836799
references.citation: Nucleic Acids Res. 2004 Feb 02;32(2):669-80
references.pmid: 14757832
references.citation: J Gastroenterol Hepatol. 2001 Mar;16(3):338-44
references.pmid: 11339428
references.citation: Clin Cancer Res. 2003 Nov 1;9(14):5370-9
references.pmid: 14614022
references.citation: Clin Cancer Res. 2007 Mar 1;13(5):1383-8
references.pmid: 17332279
references.citation: Pharmacol Res. 2005 Jul;52(1):5-14
references.pmid: 15911329
references.citation: Neuroscience. 2007 Aug 10;148(1):198-211
references.pmid: 17640816
references.citation: Clin Cancer Res. 2003 Jul;9(7):2711-8
references.pmid: 12855651
references.citation: Pathobiology. 2009 May;76(3):108-16
references.pmid: 19468250