title: Increased oral bioavailability of itraconazole and its active metabolite, 7-hydroxyitraconazole, when coadministered with a vitamin C beverage in healthy participants.
authors.affiliation: Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, 633-165, Gaegum-Dong, Busanjin-Gu, Busan, 614-735, South Korea.
authors.forename: Soo Kyung
authors.initials: SK
authors.lastname: Bae
authors.forename: Soo-Jin
authors.initials: SJ
authors.lastname: Park
authors.forename: Eon-Jeong
authors.initials: EJ
authors.lastname: Shim
authors.forename: Ji-Hyun
authors.initials: JH
authors.lastname: Mun
authors.forename: Eun-Young
authors.initials: EY
authors.lastname: Kim
authors.forename: Jae-Gook
authors.initials: JG
authors.lastname: Shin
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Shon
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000009:adverse effects / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D001628:Beverages / Q000032:analysis*; D001682:Biological Availability; D001711:Biotransformation; D018592:Cross-Over Studies; D005260:Female; D018565:Food-Drug Interactions; D006207:Half-Life; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D008297:Male; D008825:Miconazole / Q000097:blood / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D053719:Tandem Mass Spectrometry; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; C084794:hydroxyitraconazole; D017964:Itraconazole; D008825:Miconazole; D001205:Ascorbic Acid