MicroRNAs in psychiatric and neurodevelopmental disorders.
Abnormalities in microRNA (miRNA)-mediated gene regulation have been observed in a variety of human diseases, especially in cancer. Here, we provide an account of newly emerging connections between miRNAs with various psychiatric and neurodevelopmental disorders, including recent findings of miRNA dysregulation in the 22q11.2 microdeletion syndrome, a well-established genetic risk factor for schizophrenia. miRNAs appear to be components of both the genetic architecture of these complex phenotypes as well as integral parts of the biological pathways that mediate the effects of primary genetic deficits. Therefore, they may contribute to both genetic heterogeneity and phenotypic variation of psychiatric and neurodevelopmental disorders and could serve as novel therapeutic targets.
Xu
Bin
B
Department of Physiology and Cellular Biophysics, Columbia University Medical Center, 630 W. 168th Street,New York, NY 10032, USA.
Karayiorgou
Maria
M
Gogos
Joseph A
JA
D000818:Animals; D002658:Developmental Disabilities / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D001523:Mental Disorders / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000378:metabolism*; D008959:Models, Neurological; D009422:Nervous System Diseases / Q000235:genetics / Q000378:metabolism*
D035683:MicroRNAs
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