Progress in siRNA delivery using multifunctional nanoparticles.
Nanoparticles made from synthetic polymers have been developed to deliver small interfering RNA (siRNA). For successful siRNA delivery, these nanoparticles need to efficiently encapsulate siRNA, actively target sites of interest, and release siRNA intracellularly. This chapter reviews recent progress using a multifunctional approach to design and engineer polymeric nanoparticles for siRNA delivery.
Gao
Weiwei
W
Laboratory of Nanomedicine and Biomaterials, Department of Anesthesia, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Xiao
Zeyu
Z
Radovic-Moreno
Alex
A
Shi
Jinjun
J
Langer
Robert
R
Farokhzad
Omid C
OC
D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D018014:Gene Transfer Techniques / Q000639:trends*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D034741:RNA, Small Interfering / Q000378:metabolism*
D034741:RNA, Small Interfering