Anti-human rhinovirus activity of raoulic acid from Raoulia australis.
Human rhinoviruses (HRVs), members of the Picornaviridae family, are composed of over 100 different virus serotypes. Until now there is no recorded clinically effective antiviral chemotherapeutic agent for treatment of diseases caused by HRVs. Our previous study of raoulic acid tested against serotype human rhinoviruses showed anti-HRV2 (species A) and -3 (species B) activities. In this study, raoulic acid was found to possess broad-spectrum antiviral activity against six HRVs with a 50% inhibition concentration of less than 9.5 microg/mL through inhibition of the cellular absorption of the HRV particles. Furthermore, the effect of raoulic acid on resistance of HRV5 exhibited to pleconaril was more pronounced than the effect on HRV1b, -6, -14, -15, and -40. However, ribavirin did possess weak antiviral activity against HRVs. Collectively, the results demonstrate that raoulic acid is a novel therapeutic candidate for two different groups of human rhinovirus.
Choi
Hwa Jung
HJ
Department of Clinic Laboratory Science, Daejeon Health Sciences College, Daejeon, Republic of Korea.
Song
Jae-Hyoung
JH
Lim
Chi-Hwan
CH
Baek
Seung-Hwa
SH
Kwon
Dur-Han
DH
D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D019659:Asteraceae / Q000737:chemistry*; D003139:Common Cold / Q000188:drug therapy; D006801:Humans; D008826:Microbial Sensitivity Tests; D010069:Oxadiazoles / Q000494:pharmacology; D010080:Oxazoles; D008517:Phytotherapy; D010850:Picornaviridae Infections; D010936:Plant Extracts / Q000494:pharmacology*; D012229:Rhinovirus / Q000145:classification / Q000187:drug effects*; D012254:Ribavirin / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology*; D053586:Virus Internalization / Q000187:drug effects*
D000998:Antiviral Agents; D010069:Oxadiazoles; D010080:Oxazoles; D010936:Plant Extracts; D013729:Terpenes; C535205:raoulic acid; D012254:Ribavirin; C115201:pleconaril