title: Bisphenol A in combination with TNF-alpha selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity.
abstract: Bisphenol A (BPA) is a monomer used in manufacturing a wide range of chemical products, including epoxy resins and polycarbonate. BPA, an important endocrine disrupting chemical that exerts estrogen-like activities, is detectable at nanomolar levels in human serum worldwide. The pregnancy associated doses of 17beta-estradiol (E2) plus tumor-necrosis factor-alpha (TNF-alpha) induce distorted maturation of human dendritic cells (DCs) that result in an increased capacity to induce T helper (Th) 2 responses. The current study demonstrated that the presence of BPA during DC maturation influences the function of human DCs, thereby polarizing the subsequent Th response. In the presence of TNF-alpha, BPA treatment enhanced the expression of CC chemokine ligand 1 (CCL1) in DCs. In addition, DCs exposed to BPA/TNF-alpha produced higher levels of IL-10 relative to those of IL-12p70 on CD40 ligation, and preferentially induced Th2 deviation. BPA exerts the same effect with E2 at the same dose (0.01-0.1 microM) with regard to DC-mediated Th2 polarization. These findings imply that DCs exposed to BPA will provide one of the initial signals driving the development and perpetuation of Th2-dominated immune response in allergic reactions.
authors.affiliation: Department of Neurosurgery, XuanWu Hospital, Capital University of Medical Science, Beijing, China.
authors.forename: Hongchuan
authors.initials: H
authors.lastname: Guo
authors.forename: Tianyi
authors.initials: T
authors.lastname: Liu
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Uemura
authors.forename: Shunchang
authors.initials: S
authors.lastname: Jiao
authors.forename: Deqing
authors.initials: D
authors.lastname: Wang
authors.forename: Zilin
authors.initials: Z
authors.lastname: Lin
authors.forename: Yayoi
authors.initials: Y
authors.lastname: Narita
authors.forename: Motoharu
authors.initials: M
authors.lastname: Suzuki
authors.forename: Narumi
authors.initials: N
authors.lastname: Hirosawa
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Ichihara
authors.forename: Osamu
authors.initials: O
authors.lastname: Ishihara
authors.forename: Hirosato
authors.initials: H
authors.lastname: Kikuchi
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sakamoto
authors.forename: Satoru
authors.initials: S
authors.lastname: Senju
authors.forename: Qiuhang
authors.initials: Q
authors.lastname: Zhang
authors.forename: Feng
authors.initials: F
authors.lastname: Ling
mesh_terms: D001559:Benzhydryl Compounds; D023201:CD40 Ligand / Q000276:immunology; D002454:Cell Differentiation; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology*; D004967:Estrogens / Q000276:immunology*; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis / Q000276:immunology; D018664:Interleukin-12 / Q000096:biosynthesis / Q000276:immunology; D010636:Phenols / Q000276:immunology*; D018418:Th2 Cells / Q000166:cytology / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D023201:CD40 Ligand; D004967:Estrogens; D016753:Interleukin-10; D018664:Interleukin-12; D010636:Phenols; D014409:Tumor Necrosis Factor-alpha; C006780:bisphenol A; D000098826:Bisphenol A Compounds
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