title: A general and straightforward method for the synthesis of 2-trifluoromethylbenzothiazoles.
abstract: An efficient one-pot method for the synthesis of 2-trifluoromethylbenzothiazoles by the treatment of trifluoromethylimidoyl chlorides with sodium hydrosulfide hydrate using PdCl(2) as the sole catalyst in DMSO is described. The reaction proceeds via thiolation/C-H bond functionalization/C-S bond formation in moderate to high yields with good functional group tolerance.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Ling-Ling Road, Shanghai 200032, China.
authors.forename: Jiangtao
authors.initials: J
authors.lastname: Zhu
authors.forename: Zixian
authors.initials: Z
authors.lastname: Chen
authors.forename: Haibo
authors.initials: H
authors.lastname: Xie
authors.forename: Shan
authors.initials: S
authors.lastname: Li
authors.forename: Yongming
authors.initials: Y
authors.lastname: Wu
mesh_terms: D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013440:Sulfides / Q000737:chemistry*
chemical_list: D052160:Benzothiazoles; D006845:Hydrocarbons, Fluorinated; D013440:Sulfides; C025451:sodium bisulfide