A wheel of time: the circadian clock, nuclear receptors, and physiology.
It is a long-standing view that the circadian clock functions to proactively align internal physiology with the 24-h rotation of the earth. Recent studies, including one by Schmutz and colleagues (pp. 345-357) in the February 15, 2010, issue of Genes & Development, delineate strikingly complex connections between molecular clocks and nuclear receptor signaling pathways, implying the existence of a large-scale circadian regulatory network coordinating a diverse array of physiological processes to maintain dynamic homeostasis.
Yang
Xiaoyong
X
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06519, USA. xiaoyong.yang@yale.edu <xiaoyong.yang@yale.edu>
D000818:Animals; D002940:Circadian Rhythm / Q000235:genetics / Q000502:physiology*; D005786:Gene Expression Regulation / Q000502:physiology; D051379:Mice; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*
D018160:Receptors, Cytoplasmic and Nuclear
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