title: The complete genome sequence and molecular analysis of human hepatitis E virus genotype IV identified from a Korean patient.
abstract: Hepatitis E virus (HEV) was originally identified as the etiological agent of non-HAV enterically transmitted hepatitis. One HEV strain (FJ763142) was identified from an acute viral hepatitis E patient with IgM anti-HEV in Korea. The complete genome sequence consisted of 7,238 nucleotides (nt) plus a 22-nt poly(A) tail. The strain belongs to genotype IV, with 91% homology compared with AB197674, which was found in a Japanese patient who had traveled to China. This finding suggests that HEV genotype IV already circulates in Korea, and this HEV might be the first example of an indigenous strain.
authors.affiliation: Division of Enteric and Hepatitis Viruses, Center for Infectious Diseases, Korea National Institute of Health, Nokbun-dong, Eunpyung-gu, Seoul, Republic of Korea. suni93@hanmail.net
authors.forename: Haesun
authors.initials: H
authors.lastname: Yun
authors.forename: Jin Seon
authors.initials: JS
authors.lastname: Kim
authors.forename: Hyeok Jin
authors.initials: HJ
authors.lastname: Lee
authors.forename: Sook Hyang
authors.initials: SH
authors.lastname: Jeong
authors.forename: Jeong Sim
authors.initials: JS
authors.lastname: Kim
authors.forename: Sang Jong
authors.initials: SJ
authors.lastname: Park
authors.forename: Seong Gyu
authors.initials: SG
authors.lastname: Hwang
authors.forename: Sook Kyoung
authors.initials: SK
authors.lastname: Kang
authors.forename: Youngmee
authors.initials: Y
authors.lastname: Jee
authors.forename: Jong Hyun
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000818:Animals; D001483:Base Sequence; D005260:Female; D016679:Genome, Viral; D005838:Genotype; D016751:Hepatitis E / Q000821:virology*; D016752:Hepatitis E virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007723:Korea; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D017422:Sequence Analysis, DNA