title: Immediate versus conventional loading of palatal implants in humans: a first report of a multicenter RCT.
abstract: This study aims to analyze the clinical performance of two loading concepts on second-generation palatal implants (Orthosystem, Straumann, Basel, Switzerland) in a prospective multicenter randomized controlled clinical trial. At the time of this interim analysis, 41 patients have been randomized on a 1:1 basis to one of two treatment groups. Group 1 underwent conventional loading of palatal implants after a healing period of 12 weeks (gold standard) while group 2 underwent immediate implant loading within 1 week after implant insertion. We report initial results at 6 months after functional loading. The primary outcome parameter was implant success (no implant mobility, no implant loss). The implants in both groups were initially stable at the time of insertion, and all were eligible for randomization. Twenty-two patients (group 1) were subjected to conventional implant loading after 12 weeks while 19 patients (group 2) received immediate functional loading within the first week after insertion. Direct (e.g. distal jet appliances) as well as indirect forms of anchorage (conventional or modified transpalatal arch) were used. The magnitude of orthodontic forces ranged between 1 and 4 N for the immediate loading group and between 1 and 5 N for the conventional loading group. One implant in group 1 was lost during the healing phase. One dropout was registered in group 2. Thirty-nine implants were functionally loaded for over 6 months now. These preliminary data provide first evidence of the fact that immediate loading of palatal implants yields equivalent success rates as conventional loading to 4 N after 6 months.
authors.affiliation: Department of Orthodontics, University Medical Center Mainz, Mainz, Germany. brjung@uni-mainz.de
authors.forename: Britta A
authors.initials: BA
authors.lastname: Jung
authors.forename: Winfried
authors.initials: W
authors.lastname: Harzer
authors.forename: Heinrich
authors.initials: H
authors.lastname: Wehrbein
authors.forename: Tomasz
authors.initials: T
authors.lastname: Gedrange
authors.forename: Werner
authors.initials: W
authors.lastname: Hopfenmüller
authors.forename: Gabriele
authors.initials: G
authors.lastname: Lüdicke
authors.forename: Maximilian
authors.initials: M
authors.lastname: Moergel
authors.forename: Peter
authors.initials: P
authors.lastname: Diedrich
authors.forename: Martin
authors.initials: M
authors.lastname: Kunkel
mesh_terms: D000134:Acid Etching, Dental / Q000379:methods; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D045662:Dental Etching / Q000379:methods; D015921:Dental Implants; D017267:Dental Prosthesis Design; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D057893:Immediate Dental Implant Loading / Q000379:methods*; D008297:Male; D008310:Malocclusion / Q000145:classification / Q000628:therapy; D008875:Middle Aged; D052280:Orthodontic Anchorage Procedures / Q000295:instrumentation / Q000379:methods*; D016382:Orthodontic Appliance Design; D009967:Orthodontic Appliances; D016348:Osseointegration / Q000502:physiology; D021362:Palate, Hard / Q000601:surgery*; D011446:Prospective Studies; D013314:Stress, Mechanical; D013499:Surface Properties; D014087:Tooth Movement Techniques / Q000295:instrumentation / Q000379:methods; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015921:Dental Implants
references.citation: J Periodontol. 2003 Feb;74(2):225-41
references.pmid: 12666712
references.citation: Clin Oral Implants Res. 2004 Feb;15(1):8-17
references.pmid: 14731173
references.citation: Int J Oral Maxillofac Implants. 1986 Summer;1(1):11-25
references.pmid: 3527955
references.citation: Clin Oral Implants Res. 2008 Jul;19(7):665-9
references.pmid: 18492083
references.citation: Trials. 2007 Sep 20;8:24
references.pmid: 17883841
references.citation: J Orofac Orthop. 2008 Jul;69(4):297-308
references.pmid: 18797833
references.citation: Clin Oral Implants Res. 2006 Oct;17 Suppl 2:19-34
references.pmid: 16968379
references.citation: Angle Orthod. 2009 Jan;79(1):85-90
references.pmid: 19123693
references.citation: Clin Oral Implants Res. 2004 Oct;15(5):529-39
references.pmid: 15355394
references.citation: J Craniomaxillofac Surg. 2008 Jan;36(1):21-7
references.pmid: 17988886
references.citation: Clin Oral Implants Res. 1998 Oct;9(5):348-53
references.pmid: 9835815
references.citation: Clin Oral Implants Res. 2009 Aug;20(8):833-7
references.pmid: 19508340
references.citation: Int J Periodontics Restorative Dent. 2007 Jun;27(3):277-85
references.pmid: 17694951
references.citation: Cochrane Database Syst Rev. 2009 Jan 21;(1):CD003878
references.pmid: 19160225
references.citation: Int J Oral Maxillofac Implants. 2004 Sep-Oct;19(5):721-30
references.pmid: 15508989
references.citation: Clin Oral Implants Res. 2006 Aug;17(4):445-50
references.pmid: 16907777