title: Cortical Laminar Necrosis associated with Osmotic Demyelination Syndrome.
abstract: Cortical laminar necrosis has been rarely observed in osmotic demyelination syndrome. We report a 32-year-old female patient who became comatose after the rapid correction of hyponatremia. There were high signal intensities in the pons and bilateral deep gray nuclei on T2-weighted MRI images, and linear hyperintensities along the cerebral cortices on T1-weighted images with a diffuse gyriform enhancement. MR spectroscopic findings showed a decrease of the N-acetyl aspartate peak and an increase in those of the lipid and lactate complex. The case demonstrates that a severe form of osmotic demyelination syndrome accompanying cortical laminar necrosis can result from the rapid correction of hyponatremia.
authors.affiliation: Department of Neurology, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: A-Hyun
authors.initials: AH
authors.lastname: Cho
authors.forename: Choong-Gon
authors.initials: CG
authors.lastname: Choi
authors.forename: Sang-Ahm
authors.initials: SA
authors.lastname: Lee
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