title: Senescent cells as a source of inflammatory  factors for tumor progression.
abstract: Cellular senescence, which is associated with aging, is a process by which cells enter a state of permanent cell cycle arrest, therefore constituting a potent tumor suppressive mechanism. Recent studies show that, despite the beneficial effects of cellular senescence, senescent cells can also exert harmful effects on the tissue microenvironment. The most significant of these effects is the acquisition of a senescent-associated secretory phenotype (SASP), which entails a striking increase in the secretion of pro-inflammatory cytokines. Here, we summarize our knowledge of the SASP and the impact it has on tissue microenvironments and ability to stimulate tumor progression.
authors.affiliation: Buck Institute for Age Research, 8001 Redwood Boulevard, Novato, CA 94945, USA.
authors.forename: Albert R
authors.initials: AR
authors.lastname: Davalos
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Coppe
authors.forename: Judith
authors.initials: J
authors.lastname: Campisi
authors.forename: Pierre-Yves
authors.initials: PY
authors.lastname: Desprez
mesh_terms: D000818:Animals; D016922:Cellular Senescence / Q000502:physiology*; D016207:Cytokines / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism*; D009369:Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000473:pathology
chemical_list: D016207:Cytokines
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