title: Hantavirus outbreak associated with laboratory rats in Yunnan, China.
abstract: An outbreak of hemorrhagic fever with renal syndrome occurred among students in a college (College A) in Kunming, Yunnan province, China in 2003. Subsequent investigations revealed the presence of hantavirus antibodies and antigens in laboratory rats at College A and two other institutions. Hantavirus antibodies were detected in 15 additional individuals other than the index case in these three locations. Epidemiologic data indicated that the human infections were a result of zoonotic transmission of the virus from laboratory rats. A virus was isolated from rats in College A and the full-length genome sequence revealed that this was a new Hantaan virus isolate, designated strain KY. Sequence analysis of the three genome segments indicated that this new isolate is a reassortant derived from human and rat Hantaan viruses. Further sequence analysis of the medium (M) genome segment revealed that it originated from a recombination event between two rat Hantaan virus lineages.
authors.affiliation: State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People's Republic of China.
authors.forename: Yunzhi
authors.initials: Y
authors.lastname: Zhang
authors.forename: Hailin
authors.initials: H
authors.lastname: Zhang
authors.forename: Xingqi
authors.initials: X
authors.lastname: Dong
authors.forename: Junfa
authors.initials: J
authors.lastname: Yuan
authors.forename: Huajun
authors.initials: H
authors.lastname: Zhang
authors.forename: Xinglou
authors.initials: X
authors.lastname: Yang
authors.forename: Peng
authors.initials: P
authors.lastname: Zhou
authors.forename: Xingyi
authors.initials: X
authors.lastname: Ge
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Lin-Fa
authors.initials: LF
authors.lastname: Wang
authors.forename: Zhengli
authors.initials: Z
authors.lastname: Shi
mesh_terms: D000818:Animals; D000830:Animals, Laboratory / Q000821:virology*; D001483:Base Sequence; D002681:China / Q000453:epidemiology; D004196:Disease Outbreaks; D004199:Disease Vectors; D018063:Hantaan virus / Q000145:classification / Q000235:genetics*; D006480:Hemorrhagic Fever with Renal Syndrome / Q000453:epidemiology* / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000032:analysis; D051381:Rats; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D014495:Universities; D055815:Young Adult; D015047:Zoonoses
chemical_list: D012367:RNA, Viral