Assessment of liver fat quantification in the presence of iron.
This study assesses the stability of magnetic resonance liver fat measurements against changes in T2* due to the presence of iron, which is a confound for accurate quantification. The liver T2* was experimentally shortened by intravenous infusion of a super paramagnetic iron oxide contrast agent. Low flip angle multiecho gradient echo sequences were performed before, during and after infusion. The liver fat fraction (FF) was calculated in co-localized regions-of-interest using T2* models that assumed no decay, monoexponential decay and biexponential decay. Results show that, when T2* was neglected, there was a strong underestimation of FF and with monoexponential decay there was a weak overestimation of FF. Curve-fitting using the biexponential decay was found to be problematic. The overestimation of FF may be due to remaining deficiencies in the model, although is unlikely to be important for clinical diagnosis of steatosis.
Bydder
Mark
M
University of California San Diego, San Diego, CA 92103-8226, USA. mbydder@ucsd.edu
Shiehmorteza
Masoud
M
Yokoo
Takeshi
T
Sugay
Sebastian
S
Middleton
Michael S
MS
Girard
Olivier
O
Schroeder
Michael E
ME
Wolfson
Tanya
T
Gamst
Anthony
A
Sirlin
Claude
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003287:Contrast Media; D003430:Cross-Sectional Studies; D003911:Dextrans; D005234:Fatty Liver / Q000175:diagnosis*; D005240:Feasibility Studies; D005260:Female; D052203:Ferrosoferric Oxide; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008099:Liver / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D058185:Magnetite Nanoparticles; D008297:Male; D008875:Middle Aged; D055815:Young Adult
D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; C065507:ferumoxides; D052203:Ferrosoferric Oxide
J Magn Reson Imaging. 1991 Sep-Oct;1(5):521-30
1790376
Magn Reson Med. 2004 Jan;51(1):35-45
14705043
Radiology. 2005 Dec;237(3):1048-55
16237138
Eur Radiol. 2009 Aug;19(8):2033-40
19280194
Magn Reson Med. 2007 Aug;58(2):354-64
17654578
Magn Reson Med. 2008 Nov;60(5):1122-34
18956464
Magn Reson Med. 1986 Dec;3(6):881-900
3821465
AJR Am J Roentgenol. 1991 Feb;156(2):307-12
1898804
Magn Reson Med. 2008 Mar;59(3):521-7
18306404
Radiology. 2008 May;247(2):550-7
18349314
Magn Reson Med. 1997 Apr;37(4):494-500
9094070
Transplantation. 2003 Mar 27;75(6):756-61
12660497
Magn Reson Med. 2008 Mar;59(3):571-80
18306409
Magn Reson Imaging. 1993;11(7):977-91
8231682
J Magn Reson Imaging. 2009 Jul;30(1):145-52
19557733
Radiology. 2009 Apr;251(1):67-76
19221054
J Magn Reson. 1997 Nov;129(1):35-43
9405214
Radiology. 2007 Feb;242(2):450-5
17255416
Eur J Radiol. 2007 Jun;62(3):416-22
17267159
Magn Reson Med. 2002 Mar;47(3):539-48
11870841
Magn Reson Imaging. 2000 Sep;18(7):777-86
11027870
Magn Reson Imaging. 2008 Apr;26(3):347-59
18093781
J Magn Reson. 1998 Mar;131(1):61-8
9533907