title: Complexes of 2-hydroxyacetophenone semicarbazones: A novel series of superoxide dismutase mimetics.
abstract: A series of copper(II) and zinc complexes of 2-hydroxyacetophenone semicarbazones have been prepared and evaluated as superoxide dismutase (SOD) mimetics. The SOD-like activity of parent ligands and complexes were determined by the inhibition of nitroblue tetrazolium (NBT) reduction method, using xanthine/xanthine oxidase as the superoxide radical generator. The obtained results indicate that Cu(II) complexes exhibited the most potent SOD-like activities with the IC(50) values ranging from ca. 0.2 to 4 microM. Among copper complexes, 2-hydroxy-4-methoxyacetophenone semicarbazone analog was the most active compounds (IC(50) approximately 0.2 microM).
authors.affiliation: Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran.
authors.forename: Maliheh
authors.initials: M
authors.lastname: Safavi
authors.forename: Alireza
authors.initials: A
authors.lastname: Foroumadi
authors.forename: Maryam
authors.initials: M
authors.lastname: Nakhjiri
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi
authors.forename: Abbas
authors.initials: A
authors.lastname: Shafiee
authors.forename: Hoda
authors.initials: H
authors.lastname: Ilkhani
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Ganjali
authors.forename: Seyed Jalal
authors.initials: SJ
authors.lastname: Hosseinimehr
authors.forename: Saeed
authors.initials: S
authors.lastname: Emami
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry; D009580:Nitroblue Tetrazolium / Q000737:chemistry; D012664:Semicarbazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000737:chemistry / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism; D015032:Zinc / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D012664:Semicarbazones; D009580:Nitroblue Tetrazolium; D003300:Copper; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D015032:Zinc