title: Imaging breast cancer chemotherapy response with light. Commentary on Soliman et al., p. 2605.
abstract: Diffuse optical spectroscopy (DOS), which is used to image tumor metabolic response to neoadjuvant chemotherapy (NAC), shows large changes in tumor functional parameters with significant reductions in oxy- and deoxyhemoglobin for responders versus nonresponders. Although investigational, DOS may provide a cost-effective, risk-free method for optimizing NAC drug and dosing strategies for individual patients.
authors.affiliation: Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92715, USA. bjtrombe@uci.edu
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Tromberg
authors.forename: Albert E
authors.initials: AE
authors.lastname: Cerussi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010108:Oxyhemoglobins / Q000378:metabolism; D011379:Prognosis; D015203:Reproducibility of Results; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin
references.citation: Radiology. 2004 Nov;233(2):424-31
references.pmid: 15516615
references.citation: Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4014-9
references.pmid: 17360469
references.citation: Ann Oncol. 2004 Sep;15(9):1352-7
references.pmid: 15319241
references.citation: J Nucl Med. 2003 Nov;44(11):1806-14
references.pmid: 14602864
references.citation: Med Phys. 2005 Apr;32(4):1128-39
references.pmid: 15895597
references.citation: J Biomed Opt. 2004 Jan-Feb;9(1):230-8
references.pmid: 14715078
references.citation: J Clin Oncol. 1998 Aug;16(8):2672-85
references.pmid: 9704717
references.citation: Clin Cancer Res. 2010 May 1;16(9):2605-14
references.pmid: 20406836
references.citation: Magn Reson Imaging Clin N Am. 2006 Aug;14(3):383-9, vii
references.pmid: 17098179
references.citation: Med Phys. 2008 Jun;35(6):2443-51
references.pmid: 18649477
references.citation: Neoplasia. 2008 Oct;10(10):1028-40
references.pmid: 18813360
references.citation: Radiology. 2009 Aug;252(2):551-60
references.pmid: 19508985