title: Relationship between essential tremor and cerebellar dysfunction according to age.
abstract: BACKGROUND
  The cerebellum and its neural circuitry have been assumed to play a major role in the pathophysiology of essential tremor (ET). In this study, we sought to find associations between ET and cerebellar dysfunction.
  
  
  METHODS
  We performed tandem gait test in 41 ET patients and 44 age-matched controls. Investigators assessed tandem gait by counting the number of missteps during ten-step tandem walk and each subject repeated the trial three times.
  
  
  RESULTS
  ET patients had a higher average and total numbers of missteps during tandem gait tests than control subjects (p<0.05). Sex-adjusted odds ratio of the association between tandem gait abnormality and ET was 3.40 (95% confidence intervals 1.06-10.85). According to age stratification, aged ET patients (age >/=70 years) showed significantly higher prevalence of tandem gait abnormality than young ones. Interaction terms determined by a likelihood ratio test was also statistically significant (p<0.05).
  
  
  CONCLUSIONS
  Dysfunction of cerebellar neural circuitry may be associated with the pathophysiological mechanism of ET. In addition, aging may be an important factor modifying the association.
authors.affiliation: Department of Neurology, Chonbuk National University College of Medicine, Jeonju, Korea.
authors.forename: Eui-Seong
authors.initials: ES
authors.lastname: Lim
authors.forename: Man-Wook
authors.initials: MW
authors.lastname: Seo
authors.forename: Seong-Ryong
authors.initials: SR
authors.lastname: Woo
authors.forename: Suk-Young
authors.initials: SY
authors.lastname: Jeong
authors.forename: Seul-Ki
authors.initials: SK
authors.lastname: Jeong
references.citation: Mov Disord. 2002;17 Suppl 3:S41-8
references.pmid: 11948754
references.citation: Arch Neurol. 2002 Mar;59(3):413-7
references.pmid: 11890845
references.citation: Ann Neurol. 1994 Oct;36(4):636-42
references.pmid: 7944296
references.citation: Brain. 2000 Aug;123 ( Pt 8):1568-80
references.pmid: 10908187
references.citation: Curr Opin Neurol. 1995 Aug;8(4):314-9
references.pmid: 7582049
references.citation: Mov Disord. 1994 Mar;9(2):193-6
references.pmid: 8196682
references.citation: Mov Disord. 1989;4(2):183-7
references.pmid: 2733709
references.citation: Arch Neurol. 2000 Aug;57(8):1194-8
references.pmid: 10927801
references.citation: Neurology. 2000;54(11 Suppl 4):S14-20
references.pmid: 10854347
references.citation: Mov Disord. 1998;13 Suppl 3:2-23
references.pmid: 9827589
references.citation: Brain. 2001 Nov;124(Pt 11):2278-86
references.pmid: 11673328
references.citation: J Neurol Neurosurg Psychiatry. 2002 Oct;73(4):400-5
references.pmid: 12235308
references.citation: Mov Disord. 1997 Nov;12(6):969-72
references.pmid: 9399222
references.citation: Exp Gerontol. 1995 May-Aug;30(3-4):337-47
references.pmid: 7556512
references.citation: Lancet. 1990 Oct 27;336(8722):1028-30
references.pmid: 1977019
references.citation: Muscle Nerve. 2001 Jun;24(6):716-35
references.pmid: 11360255
references.citation: Ann Neurol. 1993 Jul;34(1):82-90
references.pmid: 8517685
references.citation: Ann Neurol. 1997 Jan;41(1):32-40
references.pmid: 9005863