title: IgM, Fc mu Rs, and malarial immune evasion.
abstract: IgM is an ancestral Ab class found in all jawed vertebrates, from sharks to mammals. This ancient ancestry is shared by malaria parasites (genus Plasmodium) that infect all classes of terrestrial vertebrates with whom they coevolved. IgM, the least studied and most enigmatic of the vertebrate Igs, was recently shown to form an intimate relationship with the malaria parasite Plasmodium falciparum. In this article, we discuss how this association might have come about, building on the recently determined structure of the human IgM pentamer, and how this interaction could affect parasite survival, particularly in light of the just-discovered Fc mu R localized to B and T cell surfaces. Because this parasite may exploit an interaction with IgM to limit immune detection, as well as to manipulate the immune response when detected, a better understanding of this association may prove critical for the development of improved vaccines or vaccination strategies.
authors.affiliation: Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA.
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Czajkowsky
authors.forename: Ali
authors.initials: A
authors.lastname: Salanti
authors.forename: Sisse B
authors.initials: SB
authors.lastname: Ditlev
authors.forename: Zhifeng
authors.initials: Z
authors.lastname: Shao
authors.forename: Ashfaq
authors.initials: A
authors.lastname: Ghumra
authors.forename: J Alexandra
authors.initials: JA
authors.lastname: Rowe
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Pleass
mesh_terms: D000818:Animals; D001666:Binding Sites, Antibody / Q000235:genetics / Q000276:immunology; D005260:Female; D014644:Genetic Variation / Q000276:immunology; D006790:Host-Parasite Interactions / Q000235:genetics / Q000276:immunology*; D006801:Humans; D057131:Immune Evasion / Q000235:genetics / Q000276:immunology*; D007075:Immunoglobulin M / Q000097:blood / Q000172:deficiency / Q000378:metabolism*; D016778:Malaria, Falciparum / Q000276:immunology* / Q000469:parasitology* / Q000517:prevention & control; D008297:Male; D010963:Plasmodium falciparum / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D011485:Protein Binding / Q000235:genetics / Q000276:immunology; D011961:Receptors, Fc / Q000097:blood / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology
chemical_list: D007075:Immunoglobulin M; D011961:Receptors, Fc; C035311:immunoglobulin M receptor
references.citation: Cell. 1995 Jul 14;82(1):101-10
references.pmid: 7606775
references.citation: J Immunol. 1989 Mar 1;142(5):1702-9
references.pmid: 2918228
references.citation: Nature. 1975 Oct 16;257(5527):592-4
references.pmid: 1101075
references.citation: Parasite Immunol. 1999 Nov;21(11):555-63
references.pmid: 10583856
references.citation: Am J Trop Med Hyg. 2002 Jun;66(6):692-9
references.pmid: 12224576
references.citation: Eur J Immunol. 1992 Oct;22(10):2595-601
references.pmid: 1382992
references.citation: Trends Parasitol. 2001 Nov;17(11):545-51
references.pmid: 11872400
references.citation: Infect Immun. 2009 Jun;77(6):2482-7
references.pmid: 19307213
references.citation: Eur J Immunol. 2009 Apr;39(4):1147-56
references.pmid: 19266484
references.citation: Br Med J. 1967 Dec 9;4(5579):583-6
references.pmid: 4168495
references.citation: Nature. 2006 Feb 9;439(7077):741-4
references.pmid: 16372020
references.citation: Cell. 2005 Jul 29;122(2):183-93
references.pmid: 16051144
references.citation: Cell. 1995 Jul 14;82(1):77-87
references.pmid: 7541722
references.citation: Eur J Immunol. 1997 Oct;27(10):2708-13
references.pmid: 9368630
references.citation: Immunol Res. 2009;43(1-3):85-97
references.pmid: 18810335
references.citation: PLoS Pathog. 2007 Jun;3(6):e80
references.pmid: 17559303
references.citation: Nat Rev Microbiol. 2005 Feb;3(2):182-7
references.pmid: 15685227
references.citation: Hum Hered. 1990;40(4):231-4
references.pmid: 2379928
references.citation: J Immunol. 2006 Sep 1;177(5):3035-44
references.pmid: 16920940
references.citation: Mol Immunol. 2010 Jan;47(4):878-82
references.pmid: 19945166
references.citation: Pediatrics. 1965 Jan;35:57-64
references.pmid: 14223226
references.citation: J Immunol. 2008 Aug 1;181(3):1988-2000
references.pmid: 18641336
references.citation: Eur J Immunol. 2007 Dec;37(12):3540-50
references.pmid: 18000956
references.citation: Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2250-5
references.pmid: 10051627
references.citation: Int J Parasitol. 2009 Sep;39(11):1195-204
references.pmid: 19324047
references.citation: J Exp Med. 2006 Jun 12;203(6):1603-14
references.pmid: 16754720
references.citation: Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13795-800
references.pmid: 16945914
references.citation: Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11230-5
references.pmid: 19549827
references.citation: Int Immunol. 1995 Feb;7(2):317-30
references.pmid: 7734425
references.citation: Immunity. 2008 Jun;28(6):799-809
references.pmid: 18513998
references.citation: Science. 1996 Jun 7;272(5267):1502-4
references.pmid: 8633247
references.citation: Curr Opin Microbiol. 2006 Aug;9(4):374-80
references.pmid: 16814594
references.citation: Nat Immunol. 2000 Nov;1(5):441-6
references.pmid: 11062505
references.citation: Immunity. 2009 Jan 16;30(1):44-55
references.pmid: 19135393
references.citation: Cancer Immunol Immunother. 2004 Mar;53(3):148-52
references.pmid: 14730399
references.citation: Eur J Immunol. 2001 May;31(5):1310-6
references.pmid: 11465087
references.citation: J Mol Biol. 2009 Oct 16;393(1):202-13
references.pmid: 19695262
references.citation: J Exp Med. 2000 Jul 3;192(1):1-10
references.pmid: 10880521
references.citation: J Immunogenet. 1978 Jun;5(3):149-56
references.pmid: 690472
references.citation: Nature. 2002 Oct 3;419(6906):498-511
references.pmid: 12368864
references.citation: Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14960-5
references.pmid: 19706439
references.citation: Infect Immun. 2003 Aug;71(8):4767-71
references.pmid: 12874359
references.citation: Mol Biochem Parasitol. 2006 Apr;146(2):192-7
references.pmid: 16442168
references.citation: J Biol Chem. 2008 Aug 8;283(32):21842-6
references.pmid: 18550531
references.citation: Immunol Rev. 2008 Oct;225:272-83
references.pmid: 18837788
references.citation: Biochem Biophys Res Commun. 2006 Sep 15;348(1):183-91
references.pmid: 16876123
references.citation: J Exp Med. 1998 Dec 21;188(12):2381-6
references.pmid: 9858525
references.citation: Nat Med. 2003 Jan;9(1):93-6
references.pmid: 12483205
references.citation: Nat Med. 2003 Oct;9(10):1287-92
references.pmid: 14502281
references.citation: Science. 2001 Sep 14;293(5537):2098-100
references.pmid: 11557894
references.citation: Adv Immunol. 1985;37:151-216
references.pmid: 3890478
references.citation: Nat Struct Mol Biol. 2008 Sep;15(9):932-8
references.pmid: 19172746
references.citation: Nature. 1983 Mar 17-23;302(5905):256-8
references.pmid: 6835362
references.citation: Eukaryot Cell. 2007 Sep;6(9):1511-20
references.pmid: 17644655
references.citation: Adv Immunol. 2004;82:155-215
references.pmid: 14975257
references.citation: Infect Immun. 2005 Dec;73(12):8060-8
references.pmid: 16299300
references.citation: Science. 1999 Dec 10;286(5447):2156-9
references.pmid: 10591647
references.citation: Nat Immunol. 2004 Oct;5(10):981-6
references.pmid: 15454921
references.citation: J Exp Med. 2009 Nov 23;206(12):2779-93
references.pmid: 19858324
references.citation: J Immunol. 2010 Jan 15;184(2):844-50
references.pmid: 20018610
references.citation: J Biol Chem. 2001 Mar 16;276(11):8197-204
references.pmid: 11096107
references.citation: Immunol Lett. 2009 Aug 15;125(2):79-85
references.pmid: 19539648
references.citation: Mol Immunol. 2008 Feb;45(4):1071-7
references.pmid: 17825414
references.citation: Immunity. 2004 Sep;21(3):379-90
references.pmid: 15357949