Genome-wide association study of height and body mass index in Australian twin families.
Human height and body mass index are influenced by a large number of genes, each with small effects, along with environment. To identify common genetic variants associated with these traits, we performed genome-wide association studies in 11,536 individuals composed of Australian twins, family members, and unrelated individuals at approximately 550,000 genotyped SNPs. We identified a single genome-wide significant variant for height (P value=1.06x10(-9)) located in HHIP, a well-replicated height-associated gene. Suggestive levels of association were found for other known genes associated with height (P values<1x10(-6)): ADAMTSL3, EFEMP1, GPR126, and HMGA2; and BMI (P values<1x10(-4)): FTO and MC4R. Together, these variants explain less than 2% of total phenotypic variation for height and 0.5% for BMI.
Liu
Jimmy Z
JZ
Queensland Statistical Genetics, Genetic Epidemiology and Molecular Epidemiology Laboratories, Queensland Institute of Medical Research, Australia.
Medland
Sarah E
SE
Wright
Margaret J
MJ
Henders
Anjali K
AK
Heath
Andrew C
AC
Madden
Pamela A F
PA
Duncan
Alexis
A
Montgomery
Grant W
GW
Martin
Nicholas G
NG
McRae
Allan F
AF
D015992:Body Mass Index; D005190:Family; D005260:Female; D014644:Genetic Variation; D015894:Genome, Human; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D014427:Twins / Q000235:genetics
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