title: Improved management of intradialytic hypotension (IDH) using vitamin E-bonded polysulfone membrane dialyzer.
abstract: BACKGROUND
  Intradialytic hypotension (IDH) is a common clinical trait in hemodialysis (HD) which is caused by poor biocompatibility of the dialyzer membrane. Aiming to improve IDH, vitamin E-bonded polysulfone dialyzer (VPS-H) was evaluated in a pilot study.
  
  
  METHODS
  Eight IDH patients on standard HD were switched from their conventional high-flux dialyzers to VPS-H, and intradialytic blood pressure (BP) was monitored regularly for 10 months.
  
  
  RESULTS
  The results showed that hypotension of systolic BP (SBP), diastolic BP (DBP) and pulse pressure (PP) during the session were improved after changing the dialyzer. Notably, almost all the values recorded from 120 minutes into the session until the end of the treatment in the period between the second and tenth month after treatment were significantly different from the corresponding baseline values. Moreover, after 8 to 10 months, the SBP prior to a dialysis session was significantly reduced compared with baseline values. On the other hand, the pulse rate showed no difference throughout the study period.
  
  
  CONCLUSIONS
  This study provides early evidence of the beneficial role that vitamin E-bonded dialyzers may have in preventing IDH. Larger controlled trials are needed to confirm this original finding.
authors.affiliation: Medical Engineering Department, Toho-Hospital, Midori-shi, Gunma, Japan.
authors.forename: Masaki
authors.initials: M
authors.lastname: Matsumura
authors.forename: Hisako
authors.initials: H
authors.lastname: Sasaki
authors.forename: Kumiko
authors.initials: K
authors.lastname: Sekizuka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sano
authors.forename: Kouji
authors.initials: K
authors.lastname: Ogawa
authors.forename: Chihiro
authors.initials: C
authors.lastname: Shimizu
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yoshida
authors.forename: Satsuki
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Masahide
authors.initials: M
authors.lastname: Koremoto
authors.forename: Masaharu
authors.initials: M
authors.lastname: Aritomi
authors.forename: Kazue
authors.initials: K
authors.lastname: Ueki
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000627:therapeutic use*; D001672:Biocompatible Materials / Q000737:chemistry; D005260:Female; D006801:Humans; D007022:Hypotension / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011108:Polymers / Q000737:chemistry*; D006435:Renal Dialysis / Q000009:adverse effects / Q000295:instrumentation*; D013450:Sulfones / Q000737:chemistry*; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D001672:Biocompatible Materials; D011108:Polymers; D013450:Sulfones; D014810:Vitamin E; C017662:polysulfone P 1700