High-fat diet-induced neuropathy of prediabetes and obesity: effect of PMI-5011, an ethanolic extract of Artemisia dracunculus L.
Artemisia species are a rich source of herbal remedies with antioxidant and anti-inflammatory properties. We evaluated PMI-5011, an ethanolic extract of Artemisia dracunculus L., on neuropathy in high-fat diet-fed mice, a model of prediabetes and obesity developing oxidative stress and proinflammatory changes in peripheral nervous system. C57Bl6/J mice fed high-fat diet for 16 weeks developed obesity, moderate nonfasting hyperglycemia, nerve conduction deficit, thermal and mechanical hypoalgesia, and tactile allodynia. They displayed 12/15-lipoxygenase overexpression, 12(S)-hydroxyeicosatetraenoic acid accumulation, and nitrosative stress in peripheral nerve and spinal cord. PMI-5011 (500 mg kg(-1) d(-1), 7 weeks) normalized glycemia, alleviated nerve conduction slowing and sensory neuropathy, and reduced 12/15-lipoxygenase upregulation and nitrated protein expression in peripheral nervous system. PMI-5011, a safe and nontoxic botanical extract, may find use in treatment of neuropathic changes at the earliest stage of disease.
Watcho
Pierre
P
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA.
Stavniichuk
Roman
R
Ribnicky
David M
DM
Raskin
Ilya
I
Obrosova
Irina G
IG
D000818:Animals; D019306:Artemisia / Q000737:chemistry*; D001522:Behavior, Animal / Q000502:physiology; D001786:Blood Glucose / Q000378:metabolism; D003929:Diabetic Neuropathies / Q000188:drug therapy / Q000473:pathology; D004041:Dietary Fats; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009765:Obesity / Q000150:complications / Q000188:drug therapy; D010147:Pain Measurement; D010936:Plant Extracts / Q000627:therapeutic use*; D011236:Prediabetic State / Q000150:complications / Q000188:drug therapy
D001786:Blood Glucose; D004041:Dietary Fats; C541449:PMI-5011; D010936:Plant Extracts
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