Dual tasking and working memory in alcoholism: relation to frontocerebellar circuitry.
Controversy exists regarding the role of cerebellar systems in cognition and whether working memory compromise commonly marking alcoholism can be explained by compromise of nodes of corticocerebellar circuitry. We tested 17 alcoholics and 31 age-matched controls with dual-task, working memory paradigms. Interference tasks competed with verbal and spatial working memory tasks using low (three item) or high (six item) memory loads. Participants also underwent structural MRI to obtain volumes of nodes of the frontocerebellar system. On the verbal working memory task, both groups performed equally. On the spatial working memory with the high-load task, the alcoholic group was disproportionately more affected by the arithmetic distractor than were controls. In alcoholics, volumes of the left thalamus and left cerebellar Crus I volumes were more robust predictors of performance in the spatial working memory task with the arithmetic distractor than the left frontal superior cortex. In controls, volumes of the right middle frontal gyrus and right cerebellar Crus I were independent predictors over the left cerebellar Crus I, left thalamus, right superior parietal cortex, or left middle frontal gyrus of spatial working memory performance with tracking interference. The brain-behavior correlations suggest that alcoholics and controls relied on the integrity of certain nodes of corticocerebellar systems to perform these verbal and spatial working memory tasks, but that the specific pattern of relationships differed by group. The resulting brain structure-function patterns provide correlational support that components of this corticocerebellar system not typically related to normal performance in dual-task conditions may be available to augment otherwise dampened performance by alcoholics.
Chanraud
Sandra
S
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5723, USA.
Pitel
Anne-Lise
AL
Rohlfing
Torsten
T
Pfefferbaum
Adolf
A
Sullivan
Edith V
EV
D000328:Adult; D000437:Alcoholism / Q000150:complications* / Q000473:pathology*; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology; D001931:Brain Mapping; D002531:Cerebellum / Q000503:physiopathology*; D003072:Cognition Disorders / Q000209:etiology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008433:Mathematics; D008569:Memory Disorders / Q000209:etiology*; D008570:Memory, Short-Term / Q000502:physiology*; D008875:Middle Aged; D009434:Neural Pathways / Q000503:physiopathology; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000502:physiology; D013028:Space Perception / Q000502:physiology; D013223:Statistics as Topic; D014706:Verbal Learning / Q000502:physiology
Neuroimage. 2001 Jul;14(1 Pt 1):7-20
11525339
Drug Alcohol Depend. 2003 Jul 20;71(1):7-16
12821201
Jpn Psychol Res. 2004 May;46(2):86-97
15151568
Brain Res Brain Res Rev. 2000 Mar;31(2-3):236-50
10719151
Hum Brain Mapp. 2002 Nov;17(3):143-55
12391568
Neuropsychopharmacology. 2007 Feb;32(2):429-38
17047671
Alcohol. 2004 Jan;32(1):63-7
15066705
Science. 1966 Aug 5;153(3736):652-4
5939936
Alcohol Clin Exp Res. 2008 Jun;32(6):1001-13
18422840
Alcohol Clin Exp Res. 1995 Apr;19(2):496-500
7625588
Behav Brain Funct. 2007 Aug 20;3:42
17708762
Neuropsychology. 2000 Apr;14(2):178-88
10791858
Prog Neuropsychopharmacol Biol Psychiatry. 2002 Jun;26(5):919-27
12369267
Alcohol Clin Exp Res. 2003 Sep;27(9):1409-19
14506401
Alcohol Clin Exp Res. 1997 May;21(3):521-9
9161613
Alcohol Clin Exp Res. 2000 May;24(5):611-21
10832902
Neuroradiology. 2008 Apr;50(4):367-75
18172628
Psychiatry Res. 2005 Jun 15;135(2):81-90
15923044
Neuropsychol Rev. 2007 Sep;17(3):239-57
17874302
Neuron. 2004 Mar 4;41(5):825-37
15003180
Neuroscience. 1997 Aug;79(4):983-98
9219961
Cortex. 2010 Jul-Aug;46(7):880-95
19811779
Prog Neuropsychopharmacol Biol Psychiatry. 2003 Sep;27(6):951-61
14499312
Neuropsychology. 2004 Jul;18(3):504-13
15291728
Neuropsychopharmacology. 2009 Apr;34(5):1223-32
18615012
IEEE Trans Med Imaging. 2001 Jan;20(1):45-57
11293691
Neuroimage. 2002 Jan;15(1):273-89
11771995
Brain Res Cogn Brain Res. 1997 Jul;6(1):1-8
9395845
Cogn Neuropsychiatry. 2002 Feb;7(1):63-74
16571527
Schizophr Bull. 2000;26(1):119-36
10755673
Cogn Affect Behav Neurosci. 2004 Dec;4(4):517-27
15849894
Psychon Bull Rev. 2007 Apr;14(2):243-8
17694908
J Neurosci. 2003 Sep 10;23(23):8432-44
12968006
J Stud Alcohol. 1982 Nov;43(11):1157-70
7182675
Int J Addict. 1982 Jan;17(1):61-88
7042598
J Neurol Neurosurg Psychiatry. 1990 Oct;53(10):856-61
2266366
Q J Exp Psychol (Hove). 2007 Jan;60(1):79-100
17162509
Neuropsychology. 1997 Apr;11(2):195-206
9110327
J Clin Exp Neuropsychol. 1996 Jun;18(3):317-37
8877617
Nat Neurosci. 2002 May;5(5):479-84
11953754
Neuroimage. 2009 Jan 15;44(2):489-501
18835452
Psychopharmacology (Berl). 2007 Jun;192(2):291-8
17279375
Acta Neurol Belg. 2005 Dec;105(4):187-96
16482867
Alcohol Clin Exp Res. 1991 Jun;15(3):418-27
1877728
Mem Cognit. 2005 Mar;33(2):203-12
16028575
Alcohol Clin Exp Res. 2001 Feb;25(2):236-45
11236838
Biol Psychiatry. 2000 Aug 15;48(4):276-86
10960158
Neuropsychology. 2006 Jul;20(4):453-60
16846263
Arch Clin Neuropsychol. 2006 Jan;21(1):101-7
16216464
Science. 1999 Mar 12;283(5408):1657-61
10073923
Alcohol Clin Exp Res. 2009 Jun;33(6):977-84
19382897
Mem Cognit. 2002 Oct;30(7):1086-95
12507373
J Neurol Sci. 1989 Aug;92(1):81-9
2769304
Acta Psychiatr Scand Suppl. 1999;395:51-7
10225333
Neuroimage. 1999 Sep;10(3 Pt 1):233-60
10458940
Alcohol Clin Exp Res. 1988 Feb;12(1):81-7
3279864
J Cogn Neurosci. 2002 Nov 15;14(8):1184-99
12495525
Hum Brain Mapp. 2010 May;31(5):798-819
20017133
Percept Psychophys. 2008 Jan;70(1):36-49
18306959
Neuroimage. 2003 Aug;19(4):1510-20
12948707
J Neurosci. 2009 Jul 1;29(26):8586-94
19571149
Cereb Cortex. 2009 Oct;19(10):2485-97
19592571