title: Ectopic Cushing's syndrome due to an adrenal ganglioneuroma.
abstract: BACKGROUND
  Cushing's syndrome (CS), rare in children, is due to pituitary or, less frequently, to adrenocortical tumors. Ectopic adrenocorticotropin (ACTH) secretion is exceptional.
  
  
  METHODS
  A case of apparently ACTH-independent CS in a child is reported.
  
  
  RESULTS
  CS was due to an adrenal ganglioneuroma where neuroendocrine cells were immunopositive for ACTH responsible for the syndrome through a paracrine effect. Cortical cell hyperplasia was observed.
  
  
  CONCLUSIONS
  Benign and differentiated tumors of the neural crest such as ganglioneuromas may be responsible for CS.
authors.affiliation: Department of Nuclear Medicine, CHU Bordeaux, Bordeaux, France. jean-benoit.corcuff@chu-bordeaux.fr
authors.forename: Jean-Benoît
authors.initials: JB
authors.lastname: Corcuff
authors.forename: Colette
authors.initials: C
authors.lastname: Deminiere
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Trouillas
authors.forename: Olivier
authors.initials: O
authors.lastname: Puel
authors.forename: Yves
authors.initials: Y
authors.lastname: Perel
authors.forename: Pascal
authors.initials: P
authors.lastname: Barat
mesh_terms: D000293:Adolescent; D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000473:pathology*; D000311:Adrenal Glands / Q000473:pathology; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D003480:Cushing Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D005260:Female; D005729:Ganglioneuroma / Q000175:diagnosis / Q000473:pathology*; D006729:Hormones, Ectopic / Q000378:metabolism; D006801:Humans
chemical_list: D006729:Hormones, Ectopic; D000324:Adrenocorticotropic Hormone