[Anti-allergic properties of a novel ethyl 3-(8-fluoro-2-methyl-2,3,4,5-tetrahydropyrido[4,3-b]indol-5-yl)propionate dihydrochloride].
The influence of ethyl-3-(8-fluoro-2-methyl-2,3,4,5-tetrahydro-1H-gamma-carboline-5-yl)propionate dihydrochloride belonging to the class of gamma-carbolines on the allergic reactions (inflammation and systemic anaphylaxis) has been studied on laboratory animals. It was established that the given substance administered in a dose of 5 - 20 mg/kg exhibits a pronounced antiallergic action. Unlike many other antihistamine drugs, this gamma-carboline derivative probably does not produce sedative effect.
Ivashchenko
A V
AV
Kadieva
M G
MG
Kravchenko
D V
DV
Lavrovskiĭ
Ia V
IaV
Mit'kin
O D
OD
Salimov
R M
RM
Fedotov
Iu A
IuA
D000707:Anaphylaxis / Q000188:drug therapy / Q000276:immunology; D000818:Animals; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D002243:Carbolines / Q000627:therapeutic use*; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA
D018926:Anti-Allergic Agents; D002243:Carbolines; D006633:Histamine Antagonists; C549193:ethyl 3-(8-fluoro-2-methyl-2,3,4,5-tetrahydropyrido(4,3-b)indol-5-yl)propionate dihydrochloride