Utahmycins a and B, azaquinones produced by an environmental DNA clone.
Two new azaquinones, utahmycins A (1) and B (2), were isolated from cultures of Streptomyces albus J1704 transformed with the environmental DNA-derived Erd gene cluster. The structures of 1 and 2 were elucidated by spectroscopic analyses. The structure of 1 was confirmed by single-crystal X-ray diffraction analysis. Both metabolites appear to arise from the addition of a nitrogen atom to erdacin biosynthetic intermediates. Utahmycin A (1) is the first example of a biologically derived 1,3-dimethyl-2-azaanthraquinone.
Bauer
John D
JD
Laboratory of Genetically Encoded Small Molecules, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10065, USA.
King
Ryan W
RW
Brady
Sean F
SF
D018360:Crystallography, X-Ray; D004247:DNA; D008968:Molecular Conformation; D015394:Molecular Structure; D030781:Organisms, Genetically Modified; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification*; D013302:Streptomyces / Q000737:chemistry* / Q000235:genetics
D011809:Quinones; C550044:utahmycin A; C550043:utahmycin B; D004247:DNA
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