title: Thymocyte selection: chemokine signaling is not only about the destination.
abstract: The development and function of lymphocytes depend upon their precise migration in response to chemoattractant cytokines, or chemokines. Two recent reports suggest that, during thymic beta-selection, the binding of the chemokine CXCL12 to the receptor CXCR4 on thymocytes provides not only directional but also developmental cues.
authors.affiliation: Laboratory of Lymphocyte Biology, Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Smith 736, Boston, MA 02115, USA.
authors.forename: Michael
authors.initials: M
authors.lastname: Gleimer
authors.forename: Harald
authors.initials: H
authors.lastname: von Boehmer
mesh_terms: D000818:Animals; D017209:Apoptosis; D002454:Cell Differentiation; D049109:Cell Proliferation; D054377:Chemokine CXCL12 / Q000378:metabolism; D018925:Chemokines / Q000378:metabolism*; D002634:Chemotaxis, Leukocyte; D006801:Humans; D008213:Lymphocyte Activation; D018448:Models, Immunological; D019718:Receptors, CXCR4 / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*
chemical_list: D054377:Chemokine CXCL12; D018925:Chemokines; D019718:Receptors, CXCR4