title: Asymmetric addition of alpha-hetero-disubstituted aldehydes to vinyl sulfones; formation of highly functionalized tetrasubstituted carbon centres.
abstract: Aminal-pyrrolidine catalysed addition of alpha-hetero-disubstituted aldehydes to vinyl sulfones is described in high enantioselectivity (ee up to 97%). The obtained adducts can easily be converted to enantioenriched synthons as for example 2,2-dialkylepoxide. Evidence for a kinetic resolution is also observed.
authors.affiliation: Department of Organic Chemistry, University of Geneva, Quai Ernest Ansermet, 30, 1211, Geneva 4, Switzerland.
authors.forename: Adrien
authors.initials: A
authors.lastname: Quintard
authors.forename: Alexandre
authors.initials: A
authors.lastname: Alexakis