title: Emergence of extended-spectrum beta-lactamase and fluoroquinolone resistance genes among Irish multidrug-resistant isolates.
abstract: This study sought to identify mechanisms behind resistance to third-generation cephalosporins and ciprofloxacin in Irish multidrug-resistant Enterobacteriaceae isolates. The most prevalent extended-spectrum beta-lactamase genes identified were bla SHV-12 and bla CTX-M-15. These were associated with the fluoroquinolone resistance genes aac(6')-IB-cr, qnrA and qnrB, not previously reported in Irish isolates.
authors.affiliation: Department of Microbiology, BIOMERIT Research Centre, University College Cork, Cork, Ireland.
authors.forename: Micheál
authors.initials: M
authors.lastname: Mac Aogáin
authors.forename: Marlies J
authors.initials: MJ
authors.lastname: Mooij
authors.forename: Claire
authors.initials: C
authors.lastname: Adams
authors.forename: Jim
authors.initials: J
authors.lastname: Clair
authors.forename: Fergal
authors.initials: F
authors.lastname: O'Gara
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics*; D002511:Cephalosporins / Q000494:pharmacology; D002939:Ciprofloxacin / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology*; D005798:Genes, Bacterial; D005838:Genotype; D006801:Humans; D007494:Ireland / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D015995:Prevalence; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002511:Cephalosporins; D002939:Ciprofloxacin; D001618:beta-Lactamases