title: Antimicrobial resistance of Listeria monocytogenes strains isolated from humans in France.
abstract: Susceptibility to antibiotics of 4,816 clinical L. monocytogenes strains isolated since 1926 was studied, and the temporal evolution of susceptibility to antibiotics was analyzed through several decades. The mechanisms of resistance in each resistant strain were studied. The prevalence of resistant strains was estimated at 1.27% among isolates from humans. Resistance to tetracyclines+ and fluoroquinolones was more common and has recently emerged. Although acquired resistance in clinical L. monocytogenes did not implicate clinically relevant antibiotics, the possibility of resistance gene transfers, the description of the first clinical isolate with high-level resistance to trimethoprim, and the recent increase in penicillin MICs up to 2 microg/ml reinforce the need for microbiological surveillance.
authors.affiliation: Institut Pasteur, Centre National de Référence de la Résistance aux Antibiotiques, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Morvan
authors.forename: C
authors.initials: C
authors.lastname: Moubareck
authors.forename: A
authors.initials: A
authors.lastname: Leclercq
authors.forename: M
authors.initials: M
authors.lastname: Hervé-Bazin
authors.forename: S
authors.initials: S
authors.lastname: Bremont
authors.forename: M
authors.initials: M
authors.lastname: Lecuit
authors.forename: P
authors.initials: P
authors.lastname: Courvalin
authors.forename: A
authors.initials: A
authors.lastname: Le Monnier
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D019143:Evolution, Molecular; D005602:France / Q000453:epidemiology; D022761:Gene Transfer, Horizontal; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D066298:In Vitro Techniques; D008089:Listeria monocytogenes / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D008088:Listeriosis / Q000188:drug therapy* / Q000453:epidemiology / Q000266:history / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D017931:DNA Primers
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