title: Impact of RANTES, MCP-1 and IL-8 in mast cells.
abstract: Chemokines are cytokines with chemotactic properties on inflammatory cells and other cell types. RANTES, MCP-1 and related molecules, constitute the C-C class of chemokine supergene family and a group of cytokines produced by hematopoietic cells, while IL-8 constitute the C-X-C class. The roles of most of these chemokines are not well known, although members of the chemokine family are inflammatory agents. The C-C chemokine plays a role in regulating Th-cell cytokine production and leukocyte trafficking. In this study we clearly show that RANTES and MCP-1 are mediators of acute inflammatory responses. Our report describes additional biological activities for RANTES, MCP-1, and IL-8, suggesting that these chemokines play a fundamental role in histamine and serotonin generation and cell function in mast cells.
authors.forename: M L
authors.initials: ML
authors.lastname: Castellani
authors.forename: M A
authors.initials: MA
authors.lastname: De Lutiis
authors.forename: E
authors.initials: E
authors.lastname: Toniato
authors.forename: F
authors.initials: F
authors.lastname: Conti
authors.forename: P
authors.initials: P
authors.lastname: Felaco
authors.forename: M
authors.initials: M
authors.lastname: Fulcheri
authors.forename: T C
authors.initials: TC
authors.lastname: Theoharides
authors.forename: A
authors.initials: A
authors.lastname: Caraffa
authors.forename: P
authors.initials: P
authors.lastname: Antinolfi
authors.forename: P
authors.initials: P
authors.lastname: Conti
authors.forename: C
authors.initials: C
authors.lastname: Cuccurullo
authors.forename: C
authors.initials: C
authors.lastname: Ciampoli
authors.forename: M
authors.initials: M
authors.lastname: Felaco
authors.forename: C
authors.initials: C
authors.lastname: Orso
authors.forename: V
authors.initials: V
authors.lastname: Salini
authors.forename: G
authors.initials: G
authors.lastname: Cerulli
authors.forename: D
authors.initials: D
authors.lastname: Kempuraj
authors.forename: S
authors.initials: S
authors.lastname: Tetè
authors.forename: B
authors.initials: B
authors.lastname: Shaik
mesh_terms: D000818:Animals; D018932:Chemokine CCL2 / Q000502:physiology*; D018946:Chemokine CCL5 / Q000502:physiology*; D006636:Histamine Release / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000503:physiopathology; D018836:Inflammation Mediators / Q000502:physiology; D016209:Interleukin-8 / Q000502:physiology*; D008407:Mast Cells / Q000502:physiology*; D012701:Serotonin / Q000502:physiology; D015398:Signal Transduction
chemical_list: D018932:Chemokine CCL2; D018946:Chemokine CCL5; D018836:Inflammation Mediators; D016209:Interleukin-8; D012701:Serotonin