title: Bioavailability of iron in the regional basic diet (RBD) with dietary supplement in Brazil.
abstract: The consumption of the regional basic diet (RBD) determines a state of malnutrition found in the low-income population of Northeastern Brazil. A dietary supplement known as multimixture has been used as an alternative source of iron in food for the prevention and/or treatment of anemia and for the recovery from malnutrition. The purpose of the present work was to evaluate the bioavailability of iron in the RBD supplemented with multimixture in iron-depleted and non-depleted Wistar rats. To produce iron depletion in the animals, pretest depletion diets without iron and the pretest control diet based on the AIN-93 diet were used for 8 weeks. This phase was followed by the test diets: control, AIN-93 extrinsically labeled with (59)FeCl(3); RBD, containing carioca beans intrinsically labeled with (59)Fe; and RBDMM, RBD plus multimixture, supplied in a single meal. Hemoglobin concentration, weight gain, and dietary intake were determined in the pretest phase. Iron bioavailability was determined by the determination of total-body radiation in the animals for 7 days, using a solid scintillation detector. The hemoglobin concentration, weight gain, and dietary intake were greater in the non-depleted animals than in the iron-depleted ones. The iron bioavailability of the diets did not differ significantly. It was concluded that the multimixture did not affect the bioavailability of Fe contained in the beans of the RBD.
authors.affiliation: Laboratório de Pesquisa em Recursos Naturais (LPqRN), Instituto de Química e Biotecnologia, Universidade Federal de Alagoas, Campus Universitário A.C Simões, Maceió, AL, Brazil. pbrigide@yahoo.com.br
authors.forename: Priscila
authors.initials: P
authors.lastname: Brigide
authors.forename: Terezinha R
authors.initials: TR
authors.lastname: Ataide
authors.forename: Antônio S
authors.initials: AS
authors.lastname: Baptista
authors.forename: Solange G
authors.initials: SG
authors.lastname: Canniatti-Brazaca
authors.forename: Adibe L
authors.initials: AL
authors.lastname: Abdalla
authors.forename: Virgílio F
authors.initials: VF
authors.lastname: Nascimento Filho
authors.forename: Sonia M S
authors.initials: SM
authors.lastname: Piedade
authors.forename: Antônio E G
authors.initials: AE
authors.lastname: Sant'ana
mesh_terms: D000818:Animals; D001682:Biological Availability; D001938:Brazil; D004032:Diet; D019587:Dietary Supplements; D019266:Iron, Dietary / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019266:Iron, Dietary