title: The role of CO(2) and central chemoreception in the control of breathing in the fetus and the neonate.
abstract: Central chemoreception is active early in development and likely drives fetal breathing movements, which are influenced by a combination of behavioral state and powerful inhibition. In the premature human infant and newborn rat ventilation increases in response to CO(2); in the rat the sensitivity of the response increases steadily after ∼P12. The premature human infant is more vulnerable to instability than the newborn rat and exhibits periodic breathing that is augmented by hypoxia and eliminated by breathing oxygen or CO(2) or the administration of respiratory stimulants. The sites of central chemoreception active in the fetus are not known, but may involve the parafacial respiratory group which may be a precursor to the adult RTN. The fetal and neonatal rat brainstem-spinal-cord preparations promise to provide important information about central chemoreception in the developing rodent and will increase our understanding of important clinical problems, including The Sudden Infant Death Syndrome, Congenital Central Hypoventilation Syndrome, and periodic breathing and apnea of prematurity.
authors.affiliation: Departments of Physiology and Neurobiology and Pediatrics, Dartmouth Medical School, Borwell Building, Lebanon, NH 03756, USA. robert.a.darnall@hitchcock.org
authors.forename: Robert A
authors.initials: RA
authors.lastname: Darnall
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000196:embryology / Q000254:growth & development / Q000502:physiology*; D002245:Carbon Dioxide / Q000097:blood*; D002628:Chemoreceptor Cells / Q000502:physiology*; D047108:Embryonic Development / Q000502:physiology*; D047109:Fetal Development / Q000502:physiology*; D005333:Fetus; D006801:Humans; D007231:Infant, Newborn; D012143:Respiratory Physiological Phenomena
chemical_list: D002245:Carbon Dioxide
references.citation: Q J Exp Physiol Cogn Med Sci. 1965 Apr;50:185-95
references.pmid: 14281641
references.citation: Physiol Rev. 1983 Apr;63(2):437-83
references.pmid: 6403953
references.citation: Pediatr Res. 1996 Sep;40(3):504-7
references.pmid: 8865291
references.citation: J Appl Physiol (1985). 2001 Sep;91(3):1298-306
references.pmid: 11509529
references.citation: J Neurophysiol. 2006 Jul;96(1):55-61
references.pmid: 16495360
references.citation: Acta Physiol Scand. 1983;119(2):139-46
references.pmid: 6419543
references.citation: Am J Obstet Gynecol. 1987 Dec;157(6):1403-5
references.pmid: 3425648
references.citation: J Physiol. 1995 Sep 15;487 ( Pt 3):677-84
references.pmid: 8544130
references.citation: N Engl J Med. 1970 Feb 26;282(9):461-6
references.pmid: 5411868
references.citation: Respir Physiol. 1993 Sep;93(3):327-36
references.pmid: 8235131
references.citation: Pediatrics. 1979 Mar;63(3):355-60
references.pmid: 440836
references.citation: Am J Obstet Gynecol. 1978 Nov 1;132(5):507-13
references.pmid: 152584
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1979 Jun;46(6):1081-5
references.pmid: 224015
references.citation: Respir Physiol. 2001 Sep;127(2-3):135-55
references.pmid: 11504586
references.citation: Eur J Neurosci. 2005 Aug;22(4):911-20
references.pmid: 16115214
references.citation: J Appl Physiol (1985). 2001 Jul;91(1):316-20
references.pmid: 11408446
references.citation: J Appl Physiol (1985). 1991 Apr;70(4):1796-809
references.pmid: 1905291
references.citation: Pediatrics. 1972 Aug;50(2):202-18
references.pmid: 5045350
references.citation: J Appl Physiol (1985). 1998 Dec;85(6):2314-21
references.pmid: 9843558
references.citation: J Pediatr. 1975 Apr;86(4):588-92
references.pmid: 1092821
references.citation: J Appl Physiol (1985). 2001 Jul;91(1):343-50
references.pmid: 11408450
references.citation: Respir Physiol. 1993 Dec;94(3):265-83
references.pmid: 8108606
references.citation: J Appl Physiol (1985). 1989 Jul;67(1):1-13
references.pmid: 2569452
references.citation: J Appl Physiol (1985). 1999 Oct;87(4):1333-8
references.pmid: 10517760
references.citation: J Dev Physiol. 1992 May;17(5):233-40
references.pmid: 1460248
references.citation: J Appl Physiol (1985). 1987 Mar;62(3):1010-3
references.pmid: 3571057
references.citation: Auton Neurosci. 2007 Mar 30;132(1-2):81-102
references.pmid: 17236817
references.citation: Respir Physiol Neurobiol. 2005 Nov 15;149(1-3):83-98
references.pmid: 16203213
references.citation: Am J Obstet Gynecol. 1989 May;160(5 Pt 1):1043-7
references.pmid: 2729379
references.citation: J Appl Physiol (1985). 1987 Feb;62(2):506-12
references.pmid: 3558210
references.citation: Am J Obstet Gynecol. 1980 Mar 1;136(5):609-20
references.pmid: 7355940
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1980 Feb;48(2):347-54
references.pmid: 6767669
references.citation: Neuropadiatrie. 1972 Mar;3(3):294-304
references.pmid: 5067426
references.citation: J Physiol. 1996 Aug 15;495 ( Pt 1):217-25
references.pmid: 8866364
references.citation: Pediatr Res. 2007 Sep;62(3):331-6
references.pmid: 17622961
references.citation: Semin Neonatol. 2004 Jun;9(3):213-9
references.pmid: 15050214
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1979 Sep;47(3):527-31
references.pmid: 533745
references.citation: J Appl Physiol (1985). 1991 Apr;70(4):1431-46
references.pmid: 2055820
references.citation: Pediatrics. 1967 Sep;40(3):403-11
references.pmid: 5298530
references.citation: Pediatr Res. 2007 Nov;62(5):591-6
references.pmid: 17805205
references.citation: Respir Physiol Neurobiol. 2004 Nov 30;144(1):35-44
references.pmid: 15522701
references.citation: Exp Brain Res. 1992;89(2):459-64
references.pmid: 1623989
references.citation: Am J Physiol Regul Integr Comp Physiol. 2009 Jul;297(1):R124-34
references.pmid: 19420287
references.citation: Early Hum Dev. 1979 Mar;3(1):79-83
references.pmid: 118862
references.citation: Neuroscience. 1999 Mar;90(3):1001-11
references.pmid: 10218799
references.citation: Am J Obstet Gynecol. 2002 Apr;186(4):663-8
references.pmid: 11967488
references.citation: Biol Neonate. 1994;66(4):188-94
references.pmid: 7865634
references.citation: J Physiol. 1984 Jun;351:25-37
references.pmid: 6747866
references.citation: J Physiol. 1987 Jan;382:373-83
references.pmid: 3625554
references.citation: J Appl Physiol (1985). 2006 Oct;101(4):1097-103
references.pmid: 16794027
references.citation: J Physiol. 1992 Oct;456:39-48
references.pmid: 1293280
references.citation: Behav Neurosci. 2002 Oct;116(5):912-7
references.pmid: 12369810
references.citation: J Physiol. 1972 Apr;222(2):267-95
references.pmid: 5033464
references.citation: Pediatrics. 1979 Apr;63(4):528-31
references.pmid: 440861
references.citation: J Appl Physiol (1985). 1998 Jul;85(1):84-90
references.pmid: 9655759
references.citation: Am J Physiol. 1992 Jul;263(1 Pt 2):H162-7
references.pmid: 1636755
references.citation: Psychosom Med. 1969 Sep-Oct;31(5):372-88
references.pmid: 5350296
references.citation: J Appl Physiol (1985). 1986 Jul;61(1):160-4
references.pmid: 3525501
references.citation: Respir Physiol. 1983 Apr;52(1):99-111
references.pmid: 6306748
references.citation: J Appl Physiol. 1976 Jul;41(1):41-5
references.pmid: 972130
references.citation: Pediatrics. 1975 May;55(5):614-20
references.pmid: 1128987
references.citation: Pediatr Res. 1991 Nov;30(5):491-5
references.pmid: 1754307
references.citation: Early Hum Dev. 1986 Apr;13(2):183-8
references.pmid: 3709398
references.citation: Ann Med Exp Biol Fenn. 1966;44(1):71-3
references.pmid: 5958687
references.citation: J Appl Physiol (1985). 1996 Jun;80(6):1949-57
references.pmid: 8806899
references.citation: Respir Physiol. 2001 Nov 1;128(2):235-40
references.pmid: 11812388
references.citation: Biol Neonate. 1993;63(3):139-46
references.pmid: 8324092
references.citation: Pediatr Res. 1997 Jan;41(1):90-5
references.pmid: 8979295
references.citation: J Dev Physiol. 1993 Jan;19(1):23-8
references.pmid: 8354849
references.citation: Pediatr Res. 1985 Aug;19(8):791-6
references.pmid: 3929222
references.citation: Biol Neonat. 1964;7:243-54
references.pmid: 14310840
references.citation: Early Hum Dev. 2001 Oct;65(1):21-37
references.pmid: 11520626
references.citation: J Appl Physiol (1985). 1988 Mar;64(3):982-7
references.pmid: 3130372
references.citation: J Appl Physiol (1985). 1994 Dec;77(6):2734-9
references.pmid: 7896614
references.citation: J Appl Physiol (1985). 1988 Jun;64(6):2496-500
references.pmid: 3403433
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1983 Feb;54(2):536-43
references.pmid: 6403494
references.citation: Am J Obstet Gynecol. 1984 Nov 15;150(6):758-64
references.pmid: 6594049
references.citation: J Neuropathol Exp Neurol. 1997 May;56(5):509-22
references.pmid: 9143264
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1982 Sep;53(3):644-59
references.pmid: 7129986
references.citation: Sleep. 2008 May;31(5):691-9
references.pmid: 18517038
references.citation: J Appl Physiol (1985). 2009 Apr;106(4):1464-6
references.pmid: 18467549
references.citation: JAMA. 2001 May 2;285(17):2199-207
references.pmid: 11325321
references.citation: Am J Physiol. 1971 Feb;220(2):333-6
references.pmid: 5540880
references.citation: J Dev Physiol. 1989 Mar;11(3):147-51
references.pmid: 2809130
references.citation: J Appl Physiol (1985). 2005 Apr;98(4):1171-6
references.pmid: 15772056
references.citation: Respir Physiol. 1988 Jan;71(1):25-32
references.pmid: 3340812
references.citation: J Appl Physiol. 1976 Nov;41(5 Pt. 1):609-11
references.pmid: 993147
references.citation: Pediatrics. 1969 Apr;43(4):510-8
references.pmid: 5777065
references.citation: J Pediatr. 2004 Mar;144(3):291-5
references.pmid: 15001929
references.citation: Respir Physiol Neurobiol. 2005 Nov 15;149(1-3):165-79
references.pmid: 15876557
references.citation: Am J Physiol. 1986 Oct;251(4 Pt 2):R811-7
references.pmid: 3766782
references.citation: Pediatr Res. 1988 Mar;23(3):257-61
references.pmid: 3353170
references.citation: J Appl Physiol. 1976 Oct;41(4):502-7
references.pmid: 985392
references.citation: J Physiol. 1996 Feb 15;491 ( Pt 1):261-9
references.pmid: 9011618
references.citation: J Physiol. 1982 May;326:461-74
references.pmid: 6809936
references.citation: Reprod Fertil Dev. 1996;8(1):23-33
references.pmid: 8713720
references.citation: J Appl Physiol (1985). 1987 Mar;62(3):1033-9
references.pmid: 3571060
references.citation: Obstet Gynecol. 1980 Jul;56(1):35-8
references.pmid: 7383484
references.citation: J Appl Physiol. 1975 Dec;39(6):896-9
references.pmid: 1213968
references.citation: Am J Respir Crit Care Med. 1997 Feb;155(2):649-53
references.pmid: 9032208
references.citation: Respir Physiol. 2000 Sep;122(2-3):167-82
references.pmid: 10967342
references.citation: Acta Paediatr Scand. 1975 Sep;64(5):684-92
references.pmid: 1166788
references.citation: J Appl Physiol Respir Environ Exerc Physiol. 1978 Jun;44(6):909-13
references.pmid: 149779
references.citation: Respir Physiol Neurobiol. 2009 Mar 31;166(1):4-12
references.pmid: 19056522
references.citation: Respir Physiol. 1979 Aug;37(3):293-302
references.pmid: 493750
references.citation: Respir Physiol Neurobiol. 2002 Aug 1;131(3):213-22
references.pmid: 12126922
references.citation: J Appl Physiol. 1963 Sep;18:895-903
references.pmid: 14063257
references.citation: Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):59-68
references.pmid: 19712903
references.citation: J Physiol. 1983 Oct;343:495-506
references.pmid: 6644623
references.citation: Respir Physiol. 1971 Jun;12(2):230-8
references.pmid: 5568463
references.citation: J Appl Physiol (1985). 1993 Dec;75(6):2665-70
references.pmid: 8125887
references.citation: J Appl Physiol. 1976 Mar;40(3):352-6
references.pmid: 931849
references.citation: Am J Obstet Gynecol. 1981 Oct 1;141(3):271-5
references.pmid: 6974499
references.citation: Am J Respir Crit Care Med. 1996 Nov;154(5):1537-42
references.pmid: 8912777
references.citation: J Dev Physiol. 1990 Dec;14(6):337-42
references.pmid: 1966247
references.citation: J Appl Physiol (1985). 1999 Aug;87(2):484-90
references.pmid: 10444602
references.citation: Respir Physiol. 1986 Jul;65(1):55-68
references.pmid: 3749640
references.citation: Sleep Med Rev. 2003 Aug;7(4):321-34
references.pmid: 14505599
references.citation: J Physiol. 1960 Nov;154:153-68
references.pmid: 13775641
references.citation: J Neurosci. 2008 Nov 26;28(48):12845-50
references.pmid: 19036978
references.citation: J Pediatr. 1997 Feb;130(2):305-9
references.pmid: 9042137
references.citation: J Appl Physiol (1985). 2002 Mar;92(3):1133-40
references.pmid: 11842050
references.citation: J Appl Physiol (1985). 2008 Jan;104(1):198-204
references.pmid: 18006868
references.citation: J Pediatr. 1979 May;94(5):787-91
references.pmid: 36449
references.citation: Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14860-4
references.pmid: 16192355
references.citation: J Appl Physiol (1985). 2004 Mar;96(3):1216-22; discussion 1196
references.pmid: 14617530
references.citation: J Physiol. 1953 Nov 28;122(2):264-73
references.pmid: 13118537
references.citation: J Appl Physiol (1985). 1993 Sep;75(3):1027-34
references.pmid: 8226508
references.citation: J Appl Physiol (1985). 1989 Sep;67(3):1113-8
references.pmid: 2793703
references.citation: J Physiol. 2006 Feb 1;570(Pt 3):437-44
references.pmid: 16284077
references.citation: Am J Physiol Regul Integr Comp Physiol. 2009 Jun;296(6):R1783-96
references.pmid: 19369586
references.citation: Pediatr Res. 2000 Jun;47(6):813-8
references.pmid: 10832743
references.citation: Respir Physiol. 1996 Apr-May;104(1):11-22
references.pmid: 8865377
references.citation: J Physiol. 1972 Jan;220(1):119-43
references.pmid: 4333826
references.citation: Respir Physiol Neurobiol. 2009 Sep 30;168(3):239-49
references.pmid: 19616133
references.citation: J Neurophysiol. 1992 Apr;67(4):996-9
references.pmid: 1588395
references.citation: Respir Physiol Neurobiol. 2009 Aug 31;168(1-2):49-58
references.pmid: 19394450
references.citation: Respir Physiol. 1980 May;40(2):165-79
references.pmid: 7394367
references.citation: Brain Res Dev Brain Res. 1994 Jul 15;80(1-2):222-32
references.pmid: 7955347