title: Peptide and protein thioester synthesis via N-->S acyl transfer.
abstract: Peptide and protein thioesters are playing an increasingly prominent role in the chemical toolbox for protein assembly and modification through Native Chemical Ligation (NCL). In this Emerging Area we highlight recent developments in a somewhat surprising route to thioesters: selective disruption of amides, the more stable carboxylic acid derivatives.
authors.affiliation: Department of Chemistry, University College London, 20 Gordon Street, London, UK WC1H 0AJ.
authors.forename: Jaskiranjit
authors.initials: J
authors.lastname: Kang
authors.forename: Derek
authors.initials: D
authors.lastname: Macmillan
mesh_terms: D000577:Amides / Q000737:chemistry; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D010455:Peptides; D011506:Proteins; D013438:Sulfhydryl Compounds