HIV infection-related tuberculosis: clinical manifestations and treatment.
Several aspects of human immunodeficiency virus (HIV) infection-related tuberculosis (TB) and its treatment differ from those of TB in HIV-uninfected persons. The risk of TB and the clinical and radiographic manifestations of disease are primary examples. Antiretroviral therapy has a profound effect on lowering the risk of TB in HIV-infected persons, but it can also be associated with immune reconstitution inflammatory disease and unmasking of previously subclinical disease. There are also differences in treatment of HIV infection-related TB because of overlapping drug toxicities and drug-drug interactions between antiretroviral therapy and anti-TB therapy.
Sterling
Timothy R
TR
Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. timothy.sterling@vanderbilt.edu
Pham
Paul A
PA
Chaisson
Richard E
RE
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000473:pathology*; D019380:Anti-HIV Agents / Q000627:therapeutic use; D000995:Antitubercular Agents / Q000627:therapeutic use; D004347:Drug Interactions; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome; D014376:Tuberculosis / Q000188:drug therapy* / Q000473:pathology*
D019380:Anti-HIV Agents; D000995:Antitubercular Agents