title: Effect of lead toxicity on coenzyme Q levels in rat tissues.
abstract: Lead is a persistent and common environmental contaminant, which chiefly plays a significant role in modern industry. Coenzyme Q acts as electron and proton carrier in mitochondria and functions as an antioxidant in its reduced form (ubiquinol). To investigate the hazardous effects of lead on the coenzyme Q level, rats were injected i.p. with lead acetate (5 mg/kg b.wt. daily for 6 weeks). Our results showed that the levels of both oxidized (ubiquinone) and reduced (ubiquinol) forms of coenzyme Q(9) and Q(10) in serum, brain, liver and kidney of lead-treated rats are quite different depending on the organ tissue type.
authors.affiliation: Biochemistry Department, Faculty of Pharmacy, Al-Azhar University, Nasr-City, Cairo, Egypt.
authors.forename: Gamil M
authors.initials: GM
authors.lastname: Abdallah
authors.forename: El-Sayed M
authors.initials: el-SM
authors.lastname: El-Sayed
authors.forename: Osama M
authors.initials: OM
authors.lastname: Abo-Salem
mesh_terms: D000818:Animals; D007854:Lead / Q000633:toxicity*; D008297:Male; D051381:Rats; D014451:Ubiquinone / Q000378:metabolism*
chemical_list: D014451:Ubiquinone; D007854:Lead