title: Clinical characteristics of Japanese dyspeptic patients: is the Rome III classification applicable?
abstract: OBJECTIVE
  While the Rome III classification seems logical, some aspects need further evaluation. The aim of this study was to evaluate the clinical characteristics of Japanese dyspeptic patients and to determine whether this classification could be applied to them.
  
  
  METHODS
  A total of 364 consecutive patients with a mean age of 54.5 years who had chronic symptoms occurring at least several times per week that could be attributed to the upper gastrointestinal tract were recruited. All of them underwent blood tests, ultrasonography, and endoscopy, which revealed no organic, systemic, or metabolic diseases. They also answered a questionnaire about their symptoms.
  
  
  RESULTS
  The subjects were divided into a postprandial distress symptom (PDS) group, epigastric pain symptom (EPS) group, and chronic idiopathic nausea symptom group. There was considerable overlap among these groups (109/198, 55.1%), and patients with non-erosive reflux disease accounted for 52.0% (103/198) of all subjects. The Rome III classification could not be applied to 62.7% of the PDS group and 61.3% of the EPS group because the onset of symptoms occurred less than 6 months before diagnosis (4.6 +/- 0.4 months for PDS and 4.6 +/- 0.5 months for EPS).
  
  
  CONCLUSIONS
  The current Rome III criteria for functional dyspepsia dose not adequately identify a large proportion of Japanese dyspeptic patients, primarily due to earlier presentation for medical evaluation. Therefore, the 6-month period after onset of dyspeptic symptoms should be shortened at least in the Japanese population experiencing dyspeptic symptoms.
authors.affiliation: Division of Endoscopy and Ultrasonography, Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Matsushima, Kurashiki, Japan. n_manabe@hkg.odn.ne.jp
authors.forename: Noriaki
authors.initials: N
authors.lastname: Manabe
authors.forename: Ken
authors.initials: K
authors.lastname: Haruma
authors.forename: Jiro
authors.initials: J
authors.lastname: Hata
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imamura
authors.forename: Tomoari
authors.initials: T
authors.lastname: Kamada
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kusunoki
authors.forename: Eiko
authors.initials: E
authors.lastname: Sanuki
authors.forename: Shuzo
authors.initials: S
authors.lastname: Tsumaru
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Futagami
authors.forename: Yoshimi
authors.initials: Y
authors.lastname: Sadamoto
authors.forename: Tadashi
authors.initials: T
authors.lastname: Tokutomi
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Kurose
mesh_terms: D016009:Chi-Square Distribution; D002908:Chronic Disease; D004415:Dyspepsia / Q000145:classification* / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011795:Surveys and Questionnaires; D014463:Ultrasonography