[Comparative evaluation of alveolar phagocytosis response to intratracheally applied magnetite (Fe3O4) in nano- and micrometer ranges].
The authors compared cytotoxicity of magnetite (Fe3O4) particles in nanometric ranges (10 nm and 50 nm) and micrometer range (1 microm), analyzing changes in cellular subunits of bronchoalveolar lavage in 24 hours after intratracheal application of the particles. Findings are that the nanoparticles are more biologically aggressive than the micrometric particles, but induce more active and effective defensive reaction of alveolar fagocytosis.
Katsnel'son
B A
BA
Privalova
L I
LI
Degtiareva
T D
TD
Sutunkova
M P
MP
Eremenko
O S
OS
Khodos
M Ia
MIa
Kozitsina
A N
AN
Malakhova
N A
NA
Glazyrina
Iu A
IuA
D000280:Administration, Inhalation; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology*; D004195:Disease Models, Animal; D052203:Ferrosoferric Oxide / Q000008:administration & dosage / Q000633:toxicity*; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000633:toxicity*; D010587:Phagocytosis / Q000187:drug effects*; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D014132:Trachea
D052203:Ferrosoferric Oxide