Plasma organochlorine levels and risk of non-Hodgkin lymphoma in the Nurses' Health Study.
Numerous studies have reported positive associations of environmental exposure to polychlorinated biphenyls (PCB) and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) with the risk of non-Hodgkin lymphoma (NHL). In a case-control study nested within the Nurses' Health Study, a prospective cohort of U.S. women, we measured concentrations of PCBs and p,p'-DDE in blood samples from 145 women diagnosed with NHL at least 6 months after blood draw and 290 age- and race-matched controls. We used conditional logistic regression to estimate the odds ratios and 95% confidence intervals for each quartile of exposure relative to the lowest quartile. We also evaluated these associations for major histologic subtypes of NHL. There was no consistent evidence of an association of p,p'-DDE, total PCBs, immunotoxic, or individual PCB congeners with risk of NHL. These results do not support the hypothesis of a positive association between PCB exposure and development of NHL.
Laden
Francine
F
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, USA. francine.laden@channing.harvard.edu
Bertrand
Kimberly A
KA
Altshul
Larisa
L
Aster
Jon C
JC
Korrick
Susan A
SA
Sagiv
Sharon K
SK
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D015331:Cohort Studies; D003633:Dichlorodiphenyl Dichloroethylene / Q000097:blood*; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D006801:Humans; D006843:Hydrocarbons, Chlorinated / Q000097:blood*; D007306:Insecticides / Q000097:blood; D008228:Lymphoma, Non-Hodgkin / Q000097:blood* / Q000209:etiology*; D008875:Middle Aged; D009726:Nurses / Q000706:statistics & numerical data*; D011078:Polychlorinated Biphenyls / Q000097:blood*; D011446:Prospective Studies; D012307:Risk Factors; D016387:Women's Health
D004785:Environmental Pollutants; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D003633:Dichlorodiphenyl Dichloroethylene; D011078:Polychlorinated Biphenyls
Epidemiology. 1992 May;3(3):266-70
1317221
J Natl Cancer Inst. 1998 Sep 2;90(17):1292-9
9731736
Arch Environ Contam Toxicol. 1989 Jul-Aug;18(4):495-500
2505694
Cancer Epidemiol Biomarkers Prev. 2007 Mar;16(3):373-6
17337641
Occup Environ Med. 2008 Feb;65(2):132-40
17699548
Cancer Res. 2007 Jun 1;67(11):5545-52
17545638
Environ Res. 2001 Oct;87(2):99-107
11683593
Cancer Res. 2005 Dec 1;65(23):11214-26
16322272
Environ Health Perspect. 1997 Jan;105(1):13-4
9074863
Environ Health Perspect. 2004 Jun;112(8):854-61
15175172
Int J Cancer. 2007 Dec 15;121(12):2767-75
17722095
Lancet. 1997 Jul 26;350(9073):240-4
9242800
Epidemiology. 2010 Mar;21(2):172-80
20087190
Leuk Lymphoma. 2001 Aug;42(4):619-29
11697490