Properties of immunosuppressive macrophages generated by Mycobacterium intracellulare infection in M. intracellulare-susceptible and resistant mice.
Splenic macrophages (M(phi)s) generated in Mycobacterium intracellulare (Min)-infected mice exhibit suppressor activity against T cell mitogenesis. We examined profiles of the Min-induced generation of immunosuppressive M(phi)s (Min-M(phi)s) in Min-susceptible BALB/c (bcg(s)) and resistant CBA/JN (bcg(r)) mice. Min infection in BALB/c mice caused a more rapid generation of the immunosuppressive M(phi)s, which expressed M(phi) markers such as CD11b and F4/80, exhibited an increased ability to generate reactive oxygen intermediates, and inhibited IL-2 receptor expression by mitogenic T cells, than did Min infection in CBA/JN mice. Thus, the bcg gene may be related to the generation of Min-M(phi)s in host mice.
Tatano
Yutaka
Y
Department of Microbiology and Immunology, Shimane University School of Medicine, Izumo, Japan.
Shimizu
Toshiaki
T
Tomioka
Haruaki
H
D000818:Animals; D039481:CD11b Antigen / Q000276:immunology; D008264:Macrophages / Q000276:immunology* / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D015269:Mycobacterium avium Complex / Q000276:immunology*; D015270:Mycobacterium avium-intracellulare Infection / Q000276:immunology* / Q000382:microbiology; D013601:T-Lymphocytes / Q000276:immunology / Q000382:microbiology
D039481:CD11b Antigen