title: [Phospholipid content of plasma membranes and phospholipase C activity in epithelial cells of the large intestine in colitis-associated carcinogenesis in rats].
abstract: The decrease of major cytoplasmic membrane phospholipids (phosphatidylcholine and phosphatidylethanolamine) content was established in mucosal epithelial cell under colon inflammation pathology--ulcerative colitis. It was shown that aforementioned changes were associated with the increase of phospholipids' hydrolyzing enzyme--phospholipase C activity and intracellular Ca2+ concentration enlargement. Carcinogenesis stimulation under inflammation was accompanied by phospholipase C activity increase when quantity of investigated phospholipids (phosphatidylcholine, phosphatidylinozytol, phosphatidylserine) separately decreased and cytoplasmic Ca2+ value normalization was established.
authors.forename: O V
authors.initials: OV
authors.lastname: Drobins'ka
authors.forename: O O
authors.initials: OO
authors.lastname: Kravchenko
authors.forename: V A
authors.initials: VA
authors.lastname: Koval'ova
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Artemenko
authors.forename: L I
authors.initials: LI
authors.lastname: Ostapchenko
mesh_terms: D019813:1,2-Dimethylhydrazine; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D003093:Colitis, Ulcerative / Q000150:complications* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D003106:Colon / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D003110:Colonic Neoplasms / Q000201:enzymology / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D003600:Cytosol / Q000378:metabolism; D016264:Dextran Sulfate; D004195:Disease Models, Animal; D004847:Epithelial Cells / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D007413:Intestinal Mucosa / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D010738:Type C Phospholipases / Q000378:metabolism*
chemical_list: D010743:Phospholipids; D016264:Dextran Sulfate; D010738:Type C Phospholipases; D019813:1,2-Dimethylhydrazine; D002118:Calcium