IgM, Fc mu Rs, and malarial immune evasion.
IgM is an ancestral Ab class found in all jawed vertebrates, from sharks to mammals. This ancient ancestry is shared by malaria parasites (genus Plasmodium) that infect all classes of terrestrial vertebrates with whom they coevolved. IgM, the least studied and most enigmatic of the vertebrate Igs, was recently shown to form an intimate relationship with the malaria parasite Plasmodium falciparum. In this article, we discuss how this association might have come about, building on the recently determined structure of the human IgM pentamer, and how this interaction could affect parasite survival, particularly in light of the just-discovered Fc mu R localized to B and T cell surfaces. Because this parasite may exploit an interaction with IgM to limit immune detection, as well as to manipulate the immune response when detected, a better understanding of this association may prove critical for the development of improved vaccines or vaccination strategies.
Czajkowsky
Daniel M
DM
Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA.
Salanti
Ali
A
Ditlev
Sisse B
SB
Shao
Zhifeng
Z
Ghumra
Ashfaq
A
Rowe
J Alexandra
JA
Pleass
Richard J
RJ
D000818:Animals; D001666:Binding Sites, Antibody / Q000235:genetics / Q000276:immunology; D005260:Female; D014644:Genetic Variation / Q000276:immunology; D006790:Host-Parasite Interactions / Q000235:genetics / Q000276:immunology*; D006801:Humans; D057131:Immune Evasion / Q000235:genetics / Q000276:immunology*; D007075:Immunoglobulin M / Q000097:blood / Q000172:deficiency / Q000378:metabolism*; D016778:Malaria, Falciparum / Q000276:immunology* / Q000469:parasitology* / Q000517:prevention & control; D008297:Male; D010963:Plasmodium falciparum / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D011485:Protein Binding / Q000235:genetics / Q000276:immunology; D011961:Receptors, Fc / Q000097:blood / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology
D007075:Immunoglobulin M; D011961:Receptors, Fc; C035311:immunoglobulin M receptor
Cell. 1995 Jul 14;82(1):101-10
7606775
J Immunol. 1989 Mar 1;142(5):1702-9
2918228
Nature. 1975 Oct 16;257(5527):592-4
1101075
Parasite Immunol. 1999 Nov;21(11):555-63
10583856
Am J Trop Med Hyg. 2002 Jun;66(6):692-9
12224576
Eur J Immunol. 1992 Oct;22(10):2595-601
1382992
Trends Parasitol. 2001 Nov;17(11):545-51
11872400
Infect Immun. 2009 Jun;77(6):2482-7
19307213
Eur J Immunol. 2009 Apr;39(4):1147-56
19266484
Br Med J. 1967 Dec 9;4(5579):583-6
4168495
Nature. 2006 Feb 9;439(7077):741-4
16372020
Cell. 2005 Jul 29;122(2):183-93
16051144
Cell. 1995 Jul 14;82(1):77-87
7541722
Eur J Immunol. 1997 Oct;27(10):2708-13
9368630
Immunol Res. 2009;43(1-3):85-97
18810335
PLoS Pathog. 2007 Jun;3(6):e80
17559303
Nat Rev Microbiol. 2005 Feb;3(2):182-7
15685227
Hum Hered. 1990;40(4):231-4
2379928
J Immunol. 2006 Sep 1;177(5):3035-44
16920940
Mol Immunol. 2010 Jan;47(4):878-82
19945166
Pediatrics. 1965 Jan;35:57-64
14223226
J Immunol. 2008 Aug 1;181(3):1988-2000
18641336
Eur J Immunol. 2007 Dec;37(12):3540-50
18000956
Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2250-5
10051627
Int J Parasitol. 2009 Sep;39(11):1195-204
19324047
J Exp Med. 2006 Jun 12;203(6):1603-14
16754720
Proc Natl Acad Sci U S A. 2006 Sep 12;103(37):13795-800
16945914
Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11230-5
19549827
Int Immunol. 1995 Feb;7(2):317-30
7734425
Immunity. 2008 Jun;28(6):799-809
18513998
Science. 1996 Jun 7;272(5267):1502-4
8633247
Curr Opin Microbiol. 2006 Aug;9(4):374-80
16814594
Nat Immunol. 2000 Nov;1(5):441-6
11062505
Immunity. 2009 Jan 16;30(1):44-55
19135393
Cancer Immunol Immunother. 2004 Mar;53(3):148-52
14730399
Eur J Immunol. 2001 May;31(5):1310-6
11465087
J Mol Biol. 2009 Oct 16;393(1):202-13
19695262
J Exp Med. 2000 Jul 3;192(1):1-10
10880521
J Immunogenet. 1978 Jun;5(3):149-56
690472
Nature. 2002 Oct 3;419(6906):498-511
12368864
Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14960-5
19706439
Infect Immun. 2003 Aug;71(8):4767-71
12874359
Mol Biochem Parasitol. 2006 Apr;146(2):192-7
16442168
J Biol Chem. 2008 Aug 8;283(32):21842-6
18550531
Immunol Rev. 2008 Oct;225:272-83
18837788
Biochem Biophys Res Commun. 2006 Sep 15;348(1):183-91
16876123
J Exp Med. 1998 Dec 21;188(12):2381-6
9858525
Nat Med. 2003 Jan;9(1):93-6
12483205
Nat Med. 2003 Oct;9(10):1287-92
14502281
Science. 2001 Sep 14;293(5537):2098-100
11557894
Adv Immunol. 1985;37:151-216
3890478
Nat Struct Mol Biol. 2008 Sep;15(9):932-8
19172746
Nature. 1983 Mar 17-23;302(5905):256-8
6835362
Eukaryot Cell. 2007 Sep;6(9):1511-20
17644655
Adv Immunol. 2004;82:155-215
14975257
Infect Immun. 2005 Dec;73(12):8060-8
16299300
Science. 1999 Dec 10;286(5447):2156-9
10591647
Nat Immunol. 2004 Oct;5(10):981-6
15454921
J Exp Med. 2009 Nov 23;206(12):2779-93
19858324
J Immunol. 2010 Jan 15;184(2):844-50
20018610
J Biol Chem. 2001 Mar 16;276(11):8197-204
11096107
Immunol Lett. 2009 Aug 15;125(2):79-85
19539648
Mol Immunol. 2008 Feb;45(4):1071-7
17825414
Immunity. 2004 Sep;21(3):379-90
15357949