title: Reversal of adrenal suppression with ciclesonide.
abstract: BACKGROUND
  Adrenal suppression secondary to high-dose inhaled corticosteroid use has been reported in children.
  
  
  METHODS
  The authors report the use of ciclesonide to reverse adrenal suppression secondary to inhaled fluticasone use in four pediatric patients.
  
  
  RESULTS
  In these four children, hypothalamic-pituitary-adrenal axis function normalized after the patients were changed to ciclesonide, while good asthma control was maintained.
  
  
  CONCLUSIONS
  Ciclesonide should be considered for the reversal of adrenal suppression secondary to the use of fluticasone, and perhaps other older inhaled corticosteroids as well.
authors.affiliation: Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Mariel Kupfert
authors.initials: MK
authors.lastname: Heller
authors.forename: Jessica
authors.initials: J
authors.lastname: Laks
authors.forename: Thomas Andrew
authors.initials: TA
authors.lastname: Kovesi
authors.forename: Alexandra
authors.initials: A
authors.lastname: Ahmet
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000311:Adrenal Glands / Q000187:drug effects*; D001249:Asthma / Q000188:drug therapy*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011282:Pregnenediones / Q000627:therapeutic use*
chemical_list: D000305:Adrenal Cortex Hormones; D011282:Pregnenediones; C120481:ciclesonide