title: Vasculitic multiplex mononeuritis: polyarteritis nodosa versus cryoglobulinemic vasculitis.
abstract: A 76-year-old female patient presented with a progressive motor-sensory multiplex mononeuritis (MM). Combined muscle and nerve biopsy showed the typical findings of a polyarteritis nodosa (PAN). Despite treatment with corticosteroids paresthesias increased and purpura of the legs newly appeared. Hepatitis screening revealed chronic hepatitis C-infection associated with cryoglobulinemia Type II (IgM-kappa Ig A). Finally, we diagnosed a hepatitis C-associated cryoglobulinemic vasculitis based on clinical and laboratory findings.
authors.affiliation: Alfried-Krupp-Krankenhaus, Essen, Germany. costeidl@gmx.de
authors.forename: Corinna
authors.initials: C
authors.lastname: Steidl
authors.forename: Martin W
authors.initials: MW
authors.lastname: Baumgaertel
authors.forename: Eva
authors.initials: E
authors.lastname: Neuen-Jacob
authors.forename: Peter
authors.initials: P
authors.lastname: Berlit
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D001706:Biopsy; D003449:Cryoglobulinemia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000821:virology; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D020422:Mononeuropathies / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000821:virology; D010291:Paresis / Q000209:etiology; D010488:Polyarteritis Nodosa / Q000150:complications* / Q000175:diagnosis; D011693:Purpura / Q000209:etiology; D012678:Sensation Disorders / Q000209:etiology; D016896:Treatment Outcome; D014657:Vasculitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000821:virology
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents
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