AA-type amyloidosis in association with non-Hodgkin's lymphoma following CMV viremia: Autopsy case.
Amyloidosis in non-Hodgkin's lymphoma (NHL) is known to be of the AL type, and AA-type amyloidosis in NHL is extremely rare. Herein is reported an autopsy case of follicular lymphoma that transformed to diffuse large B-cell lymphoma (DLBCL) in a relapse associated with systemic AA amyloidosis. CMV infection in an immunocompromised state with chemotherapy against DLBCL may have been involved in amyloid accumulation. The serum amyloid A (SAA)1 gene polymorphism, SAA1.2/1.3, might have also been another factor in this case, considering the risk of AA amyloidosis in Japanese patients with rheumatoid arthritis.
Tajima
Shogo
S
Department of Pathology, Kanto Medical Center NTT EC, Tokyo, Japan. stajima-tky@umin.ac.jp
Ushijima
Tomonori
T
Matuya
Shoji
S
Horiuchi
Hajime
H
D000483:Alleles; D000686:Amyloidosis / Q000150:complications / Q000235:genetics / Q000473:pathology*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000235:genetics / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D005838:Genotype; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000235:genetics / Q000473:pathology*; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D000685:Serum Amyloid A Protein / Q000235:genetics; D014766:Viremia / Q000150:complications / Q000235:genetics / Q000473:pathology*
C521404:SAA1 protein, human; D000685:Serum Amyloid A Protein