Anti-Saccharomyces cerevisiae antibodies are frequent in type 1 diabetes.
Anti-Saccharomyces cerevisiae antibodies (ASCA) have been described in many autoimmune diseases in which there is an increased intestinal permeability. Also in type 1 diabetes (T1D), there is an increased intestinal permeability. Since no data are available about ASCA in T1D, we evaluated, retrospectively, the frequency of ASCA in this disease. ASCA, IgG, and IgA, were determined by ELISA in sera of 224 T1D patients in which coeliac disease has been excluded and 157 healthy control group. The frequency of ASCA (IgG or IgA) was significantly higher in T1D patients than in the control group (24.5% vs. 2.5%, p < 10(-7)). The same observation was found in children and in adult patients when we compare them to healthy children and blood donors group respectively. Compared to children, adult patients with T1D showed significantly higher frequencies of ASCA of any isotype (38% vs. 13.7%, p < 10(-4)), both ASCA IgG and IgA (12% vs. 1.6%, p = 0.002), ASCA IgG (35% vs. 9.8%, p < 10(-5)) and ASCA IgA (15% vs. 5.6%, p = 0.001). The frequency of ASCA was statistically higher in females of all T1D than in males (30.8% vs.17.7%, p = 0.03), in girls than in boys (22% vs.6.2%, p = 0.017), and significantly higher in men than in boys (35.7% vs. 6.2%, p < 10(-4)). The frequency of ASCA IgG was significantly higher than that of ASCA IgA in all T1D patients (21% vs. 9.8%, p < 0.002), in all females (26.5% vs. 10.2%, p < 0.002), in women (37.9% vs. 12%, p < 0.001). The frequency of ASCA was significantly higher in all long-term T1D than in an inaugural T1D (29% vs. 14.5%, p = 0.019). The same observation was found in adults (45.8% vs. 17.8%, p = 0.01). In long-term T1D patients, ASCA were significantly more frequent in adults than children (45.8% vs. 14.5%, p < 10(-4)). The frequency of ASCA IgG was significantly higher in long-term T1D than in an inaugural T1D (25.2% vs. 11.6%, p = 0.03). Patients with T1D had a high frequency of ASCA.
Sakly
Wahiba
W
Research unit (03UR/07-02), Faculty of Pharmacy, Rue Avicenne, 5000, Monastir, Tunisia.
Mankaï
Amani
A
Sakly
Nabil
N
Thabet
Yosra
Y
Achour
Achouak
A
Ghedira-Besbes
Leila
L
Jeddi
Moncef
M
Ghedira
Ibtissem
I
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000908:Antibodies, Fungal / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000276:immunology / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008297:Male; D008875:Middle Aged; D012441:Saccharomyces cerevisiae / Q000276:immunology*; D012737:Sex Factors
D000908:Antibodies, Fungal; D007070:Immunoglobulin A; D007074:Immunoglobulin G
Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5115-20
17360338
Med Hypotheses. 2008;70(6):1207-9
18249499
Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17729-33
16317068
Eur J Gastroenterol Hepatol. 2006 Jan;18(1):75-8
16357623
Diabetologia. 2006 Dec;49(12):2824-7
17028899
N Engl J Med. 2008 Dec 25;359(26):2767-77
19073967
Autoimmunity. 2002 Aug;35(5):365-8
12515291
J Rheumatol. 1999 Jan;26(1):128-35
9918253
Diabetes. 2008 Oct;57(10):2555-62
18820210
Ann Rheum Dis. 2001 Jan;60(1):65-6
11114285
J Med Microbiol. 2000 Mar;49(3):291-293
10707950
J Pediatr Endocrinol Metab. 2007 Dec;20(12):1257-64
18341084
Diabetes. 2003 Sep;52(9):2287-95
12941768
Lupus. 2009 Oct;18(12):1087-90
19762383
Diabetes Care. 1997 Jul;20(7):1183-97
9203460
Diabetes. 2005 Dec;54 Suppl 2:S125-36
16306330
Ann N Y Acad Sci. 2009 May;1165:195-205
19538307
J Am Acad Dermatol. 2006 Feb;54(2 Suppl):S14-7
16427984
Autoimmun Rev. 2008 Jul;7(7):550-7
18625444
Dig Dis Sci. 2006 Sep;51(9):1607-13
16937077
Dig Dis Sci. 2010 Apr;55(4):1026-31
19399613
Scand J Gastroenterol. 2007 Jul;42(7):821-6
17558905
Dig Dis Sci. 2008 Jul;53(7):1983-7
18049897
Aliment Pharmacol Ther. 2006 May 15;23(10):1455-61
16669960
Diabetes. 2006 May;55(5):1443-9
16644703
Lancet. 2000 Apr 29;355(9214):1518-9
10801176
Clin Exp Rheumatol. 2002 Jul-Aug;20(4 Suppl 26):S21-4
12371630
Gastroenterol Clin Biol. 2007 May;31(5):462-6
17541335
Pathol Biol (Paris). 2006 Feb;54(1):10-3
16376174
Gastroenterology. 2006 May;130(6):1764-75
16697740
Diabetes. 2004 Jul;53(7):1680-3
15220190
J Clin Immunol. 2009 Mar;29(2):190-5
18987962
Minerva Gastroenterol Dietol. 2009 Mar;55(1):37-40
19212306
Hepatogastroenterology. 2009 Jan-Feb;56(89):162-6
19453050
Pathol Biol (Paris). 2005 May;53(4):204-9
15850953
Rheumatology (Oxford). 2008 Feb;47(2):142-4
18160421
J Clin Endocrinol Metab. 2003 Jan;88(1):162-5
12519846
Eur J Endocrinol. 2001 Dec;145(6):757-61
11720901
Diabetes Res Clin Pract. 2008 Mar;79(3):e8-9
18177974