title: Dietary vitamin K guidance: an effective strategy for stable control of oral anticoagulation?
abstract: Numerous risk factors for instability of oral anticoagulation have been identified, including variability in vitamin K intake. However, few studies have directly tested the feasibility of manipulating dietary vitamin K to achieve stable oral anticoagulation. Recent findings from a randomized clinical trial suggest that dietary vitamin K manipulation is a viable option for managing stability of oral anticoagulant therapy. The approach appears to be effective for those patients who are under-anticoagulated and consume a small number of vitamin K-rich food sources. While an encouraging option for management of warfarin therapy, longer-term studies in different patient populations are required.
authors.affiliation: Vitamin K Laboratory, USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachussetts 02111, USA. sarah.booth@tufts.edu
authors.forename: Sarah L
authors.initials: SL
authors.lastname: Booth
mesh_terms: D000925:Anticoagulants / Q000008:administration & dosage / Q000627:therapeutic use*; D001778:Blood Coagulation Disorders / Q000097:blood / Q000188:drug therapy*; D004355:Drug Stability; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D014812:Vitamin K / Q000008:administration & dosage / Q000627:therapeutic use*; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D014812:Vitamin K; D014859:Warfarin