[Studies on anti-tumor and enhancing immunity activity of toad coat].
OBJECTIVE
To study the anti-tumor and immunity activity of toad coat (Chantui), which is a new officinal part of Bufo bufo gargarizans.


METHODS
The tumor weight of S180, H22, Lewis lung cancer cell inoculated in mice were compared between the groups of mice, fed with toad coat, and those which were not (control group). The average longevity of the mice with HCA fed with toad coat was also compared with the control group. The T lymphocyte transformation and NK cell killing activity were tested and compared with the control group. The condition of the mice which were fed with great dosage of Chantui (16 g x kg(-1) x d(-1)) was observed.


RESULTS
The tumor weight was remarkably reduced in the groups which were fed with toad coat compared with the control group. Tests show that toad coat can raise the activity of both T lymphocyte and NK cell. There was no obvious side-effect when the mice were fed with great dosage of toad coat.


CONCLUSIONS
The results show that toad coat has a strong inhibitory activity against tumors inoculated in mice and a strong enhancement of immune activity, so it could be viewed as a new valuable safe medicinal source.
Miao
Zhulei
Z
Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. mzhulei@hotmail.com
Zhang
Kang
K
Yang
Mingze
M
Zhou
Xiujia
X
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002023:Bufo bufo; D045744:Cell Line, Tumor; D005260:Female; D007694:Killer Cells, Natural / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D011897:Random Allocation; D012867:Skin / Q000737:chemistry*; D013601:T-Lymphocytes / Q000276:immunology; D047368:Tumor Burden / Q000187:drug effects
D000970:Antineoplastic Agents