title: Novel mathematical model for predicting the dissolution profile of spherical particles under non-sink conditions.
abstract: A mechanistic mathematical model was designed to predict dissolution patterns under non-sink conditions. Sulfamethoxazole was used as a model drug, and its physico-chemical properties such as solubility, density, and intrinsic dissolution rate constant etc., were investigated in order to apply these experimental values to the proposed model. Dissolution tests were employed as a way of validating the mathematical model, and it was found that the predictions given by the model were surprisingly accurate for all particle sizes. In addition, a simulation focused on forecasting the fraction of the drug that was dissolved at a certain time point when various initial particle diameters were used was also particularly valuable. Therefore, these results demonstrated that the model enables dissolution profiles to be analyzed under non-sink conditions.
authors.affiliation: School of Pharmaceutical Sciences, University of Shizuoka, Suruga-ku, Shizuoka, Japan.
authors.forename: Yasuyoshi
authors.initials: Y
authors.lastname: Agata
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Iwao
authors.forename: Atsuo
authors.initials: A
authors.lastname: Miyagishima
authors.forename: Shigeru
authors.initials: S
authors.lastname: Itai
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry*; D008956:Models, Chemical; D010316:Particle Size; D012995:Solubility; D013420:Sulfamethoxazole / Q000737:chemistry*
chemical_list: D000890:Anti-Infective Agents; D013420:Sulfamethoxazole