title: Clinical and biochemical parameters in relation to serum leptin levels in South Indian children and adolescents.
abstract: OBJECTIVE
  To investigate the relationship between serum leptin and lipid profile in South Indian School children and adolescents, and to evaluate the role of serum leptin in obese, overweight and congenital heart diseased children and adolescents; in South Indian population and its correlation with anthropometric and biochemical parameters.
  
  
  METHODS
  The study included 185 school going children and adolescents. (52 obese, 49 overweight, 25 congenital heart disease children and adolescents, were compared with 59 normal controls, aged between 10-17 years). Anthropometric variables, lipid profile, fasting serum glucose were analyzed by autoanalyser and serum leptin by ELISA.
  
  
  RESULTS
  Serum leptin levels were significantly elevated in obese and overweight children than in control children (36.88+/-18.60ng/mL, 20.64+/-11.18ng/mL vs 7.97+/-2.79ng/mL; p value <0.001), and decreased in congenital heart diseased children than in control children (6.20+/-4.23 ng/mL vs 7.97+/-2.79ng/mL; p value <0.005).
  
  
  CONCLUSIONS
  This study provides a good relationship between serum leptin levels and anthropometric and biochemical parameters, such as total cholesterol, triglycerides and LDL-cholesterol. We observed negative correlation between serum leptin and fasting glucose levels and HDL-cholesterol levels were found to be non-significant among the groups. Further studies with large sample size are needed to ascertain the relationship between serum leptin and lipid profile in different groups of children and adolescents.
authors.affiliation: Department of Biochemistry, International Centre for Cardio-Thoracic and Vascular Diseases, Chennai, India.
authors.forename: Srinivasa Nageswara
authors.initials: SN
authors.lastname: Rao
authors.forename: G Prema
authors.initials: GP
authors.lastname: Gurumurthy
authors.forename: Priya
authors.initials: P
authors.lastname: Gururajan
authors.forename: Sarasa Barathi
authors.initials: SB
authors.lastname: Arumugam
authors.lastname: Saibabu
authors.forename: V
authors.initials: V
authors.lastname: Kirthivasan
authors.forename: K M
authors.initials: KM
authors.lastname: Cherian
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood*; D006801:Humans; D007194:India; D020738:Leptin / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood*; D050177:Overweight / Q000097:blood*
chemical_list: D015415:Biomarkers; D020738:Leptin; D008055:Lipids
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