title: [A case of miliary tuberculosis showing acute respiratory distress syndrome in rheumatoid arthritis].
abstract: A 62-year-old man, treated with corticosteroids and immunosuppressants for rheumatoid arthritis, visited hospital with high fever and dyspnea on exertion. A CT scan of the chest demonstrated bilateral diffuse ground glass opacities. On the basis of the findings of the CT scan, he was initially given a diagnosis of interstitial pneumonia. He was then referred to our hospital and admitted to the intensive care unit (ICU), where because of progressive respiratory failure, he was put on mechanical ventilation. A bronchoscopy specimen after intubation turned out to be positive for acid-fast bacilli, which were confirmed to be mycobacterium tuberculosis by a polymerase chain reaction test. He was given a diagnosis of miliary tuberculosis complicated with acute respiratory distress syndrome (ARDS). He died of respiratory failure despite treatment with antituberculosis drugs. The autopsy revealed necrotizing epithelioid granulomas in both lungs, mediastinal lymph nodes, the liver, both kidneys, vertebrae and other organs. Diffuse alveolar damage was also found in both lungs. It is often difficult to detect disseminated nodules in the miliary tuberculosis with ARDS. Miliary tuberculosis should be suspected in patients in an immunosuppressant state with rheumatoid arthritis, and who have respiratory symptoms or fever of unknown origin.
authors.affiliation: Department of Internal Medicine, Tokyo Dental College.
authors.forename: Tatsu
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Terashima
authors.forename: Rika
authors.initials: R
authors.lastname: Ogawa
authors.forename: Asuka
authors.initials: A
authors.lastname: Naitou
authors.forename: Jun
authors.initials: J
authors.lastname: Miyauchi
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Morishita
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Ishizaka
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D012128:Respiratory Distress Syndrome / Q000150:complications; D014391:Tuberculosis, Miliary / Q000150:complications*
chemical_list: D007166:Immunosuppressive Agents