title: Prospective memory in adults with spina bifida.
abstract: BACKGROUND
  Individuals with neurodevelopmental disorders have been observed to show accelerated cognitive aging or even dementia as early as 30 and 40 years of age. Memory deficits are an important component of age-related cognitive loss.
  
  
  METHODS
  In this study, we investigated prospective memory, which is often impaired in aging, in a group of 32 adults with spina bifida meningomyelocele (SBM), including members of the oldest living cohort successfully treated with shunts to divert excess cerebrospinal fluid, ventriculomegaly, and hydrocephalus, who are now around 50 years of age. Seventeen typically developing adults provided a comparison group.
  
  
  RESULTS
  The SBM and comparison groups differed in the prospective memory total score as well as in both time-based and event-based subscores. Prospective memory was impaired in both older and younger individuals with SBM. However, the percentage of individuals with impaired or poor prospective memory was three times higher in the older SBM group than in the younger SBM group. The results are considered in relation to specific features of the complex brain reorganization in SBM.
authors.affiliation: Program in Neurosciences & Mental Health, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada. maureen.dennis@sickkids.ca
authors.forename: Maureen
authors.initials: M
authors.lastname: Dennis
authors.forename: Rebekah
authors.initials: R
authors.lastname: Nelson
authors.forename: Derryn
authors.initials: D
authors.lastname: Jewell
authors.forename: Jack M
authors.initials: JM
authors.lastname: Fletcher
mesh_terms: D000328:Adult; D000375:Aging / Q000502:physiology*; D002557:Cerebrospinal Fluid Shunts; D005260:Female; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D008875:Middle Aged; D009483:Neuropsychological Tests; D016135:Spinal Dysraphism / Q000150:complications*
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