title: Immune mechanisms of protection: can adjuvants rise to the challenge?
abstract: For many diseases vaccines are lacking or only partly effective. Research on protective immunity and adjuvants that generate vigorous immune responses may help generate effective vaccines against such pathogens.
authors.affiliation: Howard Hughes Medical Institute and Integrated Department of Immunology, National Jewish Health, Denver, CO 80206, USA.
authors.forename: Amy S
authors.initials: AS
authors.lastname: McKee
authors.forename: Megan K L
authors.initials: MK
authors.lastname: MacLeod
authors.forename: John W
authors.initials: JW
authors.lastname: Kappler
authors.forename: Philippa
authors.initials: P
authors.lastname: Marrack
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000917:Antibody Formation / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology*; D007156:Immunologic Memory / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D014611:Vaccination / Q000379:methods*
chemical_list: D000276:Adjuvants, Immunologic
references.citation: Nat Rev Immunol. 2003 Feb;3(2):133-46
references.pmid: 12563297
references.citation: J Immunol. 2004 Feb 15;172(4):2453-60
references.pmid: 14764717
references.citation: Immunol Res. 2007;39(1-3):94-104
references.pmid: 17917058
references.citation: Nat Med. 2008 Jun;14(6):623-8
references.pmid: 18535580
references.citation: Nature. 1994 May 5;369(6475):31-7
references.pmid: 8164737
references.citation: Curr Opin Immunol. 2008 Feb;20(1):17-22
references.pmid: 18272355
references.citation: Int J Epidemiol. 1993 Dec;22(6):1154-8
references.pmid: 8144299
references.citation: Clin Infect Dis. 2006 Nov 1;43(9):1135-42
references.pmid: 17029131
references.citation: PLoS One. 2009 Jun 16;4(6):e5930
references.pmid: 19529771
references.citation: J Virol. 2006 Dec;80(23):11756-66
references.pmid: 16971435
references.citation: Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10501-6
references.pmid: 18650390
references.citation: J Immunol. 1997 Dec 1;159(11):5197-200
references.pmid: 9548456
references.citation: Science. 1996 Apr 5;272(5258):54-60
references.pmid: 8600537
references.citation: Vaccine. 2009 Dec 9;27(52):7428-35
references.pmid: 19683087
references.citation: Immunology. 2002 Jun;106(2):127-38
references.pmid: 12047742
references.citation: J Exp Med. 1984 Feb 1;159(2):365-77
references.pmid: 6198430
references.citation: Vaccine. 2006 Aug 14;24(33-34):5937-49
references.pmid: 16828940
references.citation: Immunol Rev. 2006 Jun;211:310-9
references.pmid: 16824138
references.citation: J Immunol. 1998 Sep 15;161(6):3042-9
references.pmid: 9743369
references.citation: J Immunol. 2004 May 15;172(10):6265-71
references.pmid: 15128815
references.citation: Infect Immun. 2005 Jun;73(6):3814-6
references.pmid: 15908420
references.citation: J Exp Med. 2009 Aug 3;206(8):1643-6
references.pmid: 19635860
references.citation: Semin Immunol. 2009 Apr;21(2):53-61
references.pmid: 19269850
references.citation: J Exp Med. 2003 Dec 15;198(12):1797-806
references.pmid: 14662907
references.citation: J Exp Med. 2008 Apr 14;205(4):869-82
references.pmid: 18362170
references.citation: Eur J Immunol. 2007 Nov;37(11):3089-100
references.pmid: 17948267
references.citation: Parasitology. 2006;133 Suppl:S113-44
references.pmid: 17274843
references.citation: Ann N Y Acad Sci. 2008 Nov;1143:1-20
references.pmid: 19076341
references.citation: Vaccine. 2007 Apr 12;25(15):2823-31
references.pmid: 17254671
references.citation: J Exp Med. 1937 May 31;65(6):787-800
references.pmid: 19870634
references.citation: J Infect Dis. 2008 Aug 15;198(4):544-52
references.pmid: 18582195
references.citation: Vaccine. 2006 Apr 12;24(16):3063-5
references.pmid: 16464520
references.citation: Annu Rev Immunol. 2002;20:551-79
references.pmid: 11861612
references.citation: J Exp Med. 2007 Jun 11;204(6):1487-501
references.pmid: 17548522
references.citation: J Infect Dis. 2001 Nov 15;184(10):1331-5
references.pmid: 11679925
references.citation: J Immunol. 2009 Feb 1;182(3):1253-9
references.pmid: 19155470
references.citation: Vaccine. 2009 Oct 23;27(45):6291-5
references.pmid: 19840662
references.citation: Nat Immunol. 2009 Jan;10(1):116-125
references.pmid: 19029902
references.citation: Immunity. 2007 Aug;27(2):281-95
references.pmid: 17723218
references.citation: Eur J Immunol. 1995 Dec;25(12):3256-62
references.pmid: 8566009
references.citation: J Immunol. 2008 Jul 1;181(1):17-21
references.pmid: 18566365
references.citation: N Engl J Med. 1997 Jan 9;336(2):86-91
references.pmid: 8988885
references.citation: PLoS One. 2009 Oct 27;4(10):e7611
references.pmid: 19859560
references.citation: Nat Rev Immunol. 2009 Jul;9(7):465-79
references.pmid: 19521399
references.citation: Vaccine. 2009 Apr 21;27(18):2418-25
references.pmid: 19368783
references.citation: J Immunol. 2008 Sep 15;181(6):3755-9
references.pmid: 18768827
references.citation: J Exp Med. 2003 Dec 15;198(12):1807-15
references.pmid: 14676295
references.citation: Vaccine. 2009 Oct 23;27(45):6284-90
references.pmid: 19856521
references.citation: J Immunol. 2008 Apr 15;180(8):5402-12
references.pmid: 18390722
references.citation: J Immunol. 2003 Aug 1;171(3):1602-9
references.pmid: 12874255
references.citation: Virology. 1999 Jul 5;259(2):256-61
references.pmid: 10388649
references.citation: J Infect Dis. 2005 Apr 15;191(8):1210-5
references.pmid: 15776364
references.citation: J Virol. 2008 Jun;82(11):5161-6
references.pmid: 18353950
references.citation: Vaccine. 2008 Dec 9;26(52):6777-83
references.pmid: 18835576
references.citation: J Exp Med. 1977 Sep 1;146(3):673-89
references.pmid: 302303
references.citation: Nature. 2008 Jun 19;453(7198):1122-6
references.pmid: 18496530
references.citation: Clin Infect Dis. 2008 Aug 1;47(3):401-9
references.pmid: 18558875
references.citation: Virology. 2008 Aug 15;378(1):142-50
references.pmid: 18586296
references.citation: Vaccine. 1999 Jul 16;17(22):2769-78
references.pmid: 10438046
references.citation: J Immunol. 2007 Jul 1;179(1):53-63
references.pmid: 17579021
references.citation: Lancet. 2006 Apr 8;367(9517):1173-80
references.pmid: 16616560
references.citation: N Engl J Med. 1968 Oct 24;279(17):893-900
references.pmid: 20617594
references.citation: Vaccine. 2009 Jul 16;27(33):4388-401
references.pmid: 19450632
references.citation: Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3300-4
references.pmid: 1707538
references.citation: J Immunol. 2003 Dec 15;171(12):6961-7
references.pmid: 14662904
references.citation: N Engl J Med. 1983 Jul 7;309(1):13-7
references.pmid: 6602294
references.citation: Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10729-34
references.pmid: 16807294
references.citation: Vaccine. 2005 Feb 18;23(13):1588-95
references.pmid: 15694511
references.citation: Eur J Immunol. 2008 Aug;38(8):2085-9
references.pmid: 18624356
references.citation: Lancet. 2008 Jul 12;372(9633):164-75
references.pmid: 18620952
references.citation: J Immunol. 1999 May 1;162(9):5536-46
references.pmid: 10228035
references.citation: PLoS One. 2008 Aug 13;3(8):e2921
references.pmid: 18698342
references.citation: Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15440-5
references.pmid: 15489266
references.citation: Immunology. 2003 Sep;110(1):95-104
references.pmid: 12941146
references.citation: J Immunol. 2009 Oct 1;183(7):4403-14
references.pmid: 19734227
references.citation: N Engl J Med. 2007 Nov 8;357(19):1903-15
references.pmid: 17989383
references.citation: Infect Immun. 2003 May;71(5):2498-507
references.pmid: 12704121
references.citation: Vaccine. 2004 Dec 2;23(3):316-20
references.pmid: 15530674
references.citation: Curr Opin Immunol. 2009 Jun;21(3):339-45
references.pmid: 19493664
references.citation: J Clin Invest. 2008 Oct;118(10):3478-90
references.pmid: 18802496
references.citation: Vaccine. 2009 Dec 10;28(1):171-8
references.pmid: 19799843
references.citation: Vaccine. 1995 Nov;13(16):1557-62
references.pmid: 8578842
references.citation: Cell Immunol. 1998 May 25;186(1):18-27
references.pmid: 9637761
references.citation: Parasite Immunol. 2009 Sep;31(9):520-8
references.pmid: 19691556
references.citation: Immunity. 1996 Jan;4(1):25-36
references.pmid: 8574849
references.citation: Immunity. 2009 May;30(5):646-55
references.pmid: 19464987
references.citation: Nat Med. 2007 Jul;13(7):843-50
references.pmid: 17558415
references.citation: Nature. 1987 Dec 17-23;330(6149):664-6
references.pmid: 3120015
references.citation: Vaccine. 2002 May 31;20 Suppl 3:S24-33
references.pmid: 12184361
references.citation: Vaccine. 2004 Aug 13;22(23-24):3127-35
references.pmid: 15297065
references.citation: Nat Immunol. 2008 May;9(5):558-66
references.pmid: 18376402
references.citation: Vaccine. 2009 Dec 11;28(2):329-37
references.pmid: 19879995
references.citation: Proc Natl Acad Sci U S A. 1985 Mar;82(6):1785-9
references.pmid: 3872457
references.citation: Immunol Rev. 1997 Apr;156:53-66
references.pmid: 9176699
references.citation: Annu Rev Immunol. 2000;18:275-308
references.pmid: 10837060
references.citation: Nat Immunol. 2003 Mar;4(3):225-34
references.pmid: 12563257
references.citation: J Immunol. 1999 Jun 15;162(12):7578-83
references.pmid: 10358215
references.citation: Nat Rev Immunol. 2008 Aug;8(8):607-18
references.pmid: 18641646
references.citation: Lancet. 1984 Dec 1;2(8414):1240-2
references.pmid: 6150278
references.citation: J Immunol. 2006 May 15;176(10):6333-9
references.pmid: 16670345
references.citation: Cell Immunol. 2001 Aug 1;211(2):143-53
references.pmid: 11591118
references.citation: Immunity. 2008 May;28(5):710-22
references.pmid: 18468462
references.citation: Nat Immunol. 2004 Aug;5(8):809-17
references.pmid: 15247915
references.citation: Curr Opin Immunol. 2005 Aug;17(4):388-98
references.pmid: 15963708
references.citation: Clin Vaccine Immunol. 2008 Feb;15(2):253-9
references.pmid: 18003811
references.citation: J Exp Med. 1999 Feb 1;189(3):521-30
references.pmid: 9927514
references.citation: Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):10854-8
references.pmid: 7526382
references.citation: Vaccine. 2009 Nov 5;27 Suppl 4:D65-8
references.pmid: 19837290
references.citation: Curr Opin Immunol. 2009 Feb;21(1):10-6
references.pmid: 19223160