Feasibility of neuroendoscopic biopsy of pediatric brain tumors.
OBJECTIVE
The purpose of this study was to investigate the potential value of neuroendoscopic biopsies in pediatric patients with peri- or intraventricular tumors.


METHODS
From 2001 to 2008, 49 pediatric patients (mean age, 12.16 years) with tumors located in the intraventricular or paraventricular areas underwent neuroendoscopic biopsy, with or without simultaneous endoscopic third ventriculostomy. Neuroendoscopic biopsies were performed to verify the histological diagnosis of neoplasms and to establish pathological diagnoses necessary for planning appropriate treatment strategies.


RESULTS
In 45 of 49 patients (91.8%) neuroendoscopic biopsy specimens were appropriate for diagnosis and revealed 27 germinomas, 11 astrocytomas, and one ependymoma, etc. The tumor location included the pineal gland (n = 28), thalamus (n = 7), intraventricle (n = 3), hypothalamus (n = 3), suprasellar area (n = 2), and diffuse multifocal area (n = 3). In two patients (4.1%) biopsy specimens were informative but not diagnostic. Tumor tissue specimens were undiagnostic in two patients (4.1%). There were eight transient morbidities, including four EOM limitations, two central DI, one EVD infection, and one CSF leakage. One patient experienced postoperative tumor bleeding requiring emergent operation. There was no case of operative mortality.


CONCLUSIONS
Neuroendoscopic biopsy can be considered as the first choice for tissue sampling of periventricular and intraventricular tumors with acceptable risks.
Song
Ji Hye
JH
Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University, School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, South Korea.
Kong
Doo-Sik
DS
Shin
Hyung Jin
HJ
D000293:Adolescent; D001706:Biopsy / Q000379:methods*; D001932:Brain Neoplasms / Q000473:pathology*; D002551:Cerebral Ventricle Neoplasms / Q000473:pathology*; D002552:Cerebral Ventricles / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000473:pathology*; D007031:Hypothalamus / Q000473:pathology; D007223:Infant; D008297:Male; D044583:Neuroendoscopy / Q000379:methods*; D010870:Pineal Gland / Q000473:pathology; D010871:Pinealoma / Q000473:pathology*; D011183:Postoperative Complications / Q000209:etiology; D013786:Thalamic Diseases / Q000473:pathology*; D013788:Thalamus / Q000473:pathology; D055815:Young Adult
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