[Analysis for the organ involvement and immnunological markers of the patients with dermatomyositis].
OBJECTIVE
To investigate the characteristics of organ involvement and immunological markers in dermatomyositis(DM).


METHODS
The clinical and laboratory data including antibodies, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), immunoglobulins, protein electrophoresis of 94 DM patients were analyzed retrospectively and compared by thyroid dysfunction, interstitial lung disease and positive antinuclear antibody (ANA).


RESULTS
The incidences of positive ANA, interstitial lung disease and thyroid dysfunction were obviously increased, which were 39.4%, 34.0%, and 33.0%, respectively. Incidence of elevated tumor marker was 24.5%, which was higher than that of published reports. As compared with DM patients with negative ANA, the DM patients with positive ANA were more likely to have higher creatine kinase, abnormal immunoglobulin, and ESR (P<0.05). And for those with interstitial lung disease (ILD), the incidences of elevated tumor marker and ESR were significantly higher than those without ILD (P<0.05).


CONCLUSIONS
Positive ANA, interstitial lung disease and thyroid dysfunction are more common in DM.
Li
Yu-hui
YH
Department of Rheumatology, Peking University People's Hospital, Beijing 100044, China.
Yao
Hai-hong
HH
Zhang
Xue-wu
XW
Li
Zhan-guo
ZG
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood; D003882:Dermatomyositis / Q000150:complications / Q000276:immunology* / Q000473:pathology*; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013959:Thyroid Diseases / Q000209:etiology
D000974:Antibodies, Antinuclear; D014408:Biomarkers, Tumor