Modifier-concept of colorectal carcinogenesis: lipidomics as a technical tool in pathway analysis.
In the modifier concept of intestinal carcinogenesis, lipids have been established as important variables and one focus is given to long-chain fatty acids. Increased consumption of long-chain fatty acids is in discussion to modify the development of colorectal carcinoma in humans. Saturated long-chain fatty acids, in particular, are assumed to promote carcinogenesis, whereas polyunsaturated forms are likely to act in the opposite way. At present, the molecular mechanisms behind these effects are not well understood. Recently, it has been demonstrated by lipidomics and associated molecular techniques, that activation and metabolic channeling of long-chain fatty acids are important mechanisms to modify colorectal carcinogenesis. In this Editorial, an overview about the present concept of long-chain fatty acids and its derivatives in colorectal carcinogenesis as well as technical algorithms in lipid analysis is given.
Gassler
Nikolaus
N
Klaus
Christina
C
Kaemmerer
Elke
E
Reinartz
Andrea
A
D000214:Acyl Coenzyme A / Q000378:metabolism; D017209:Apoptosis; D002273:Carcinogens; D015179:Colorectal Neoplasms / Q000378:metabolism*; D004041:Dietary Fats; D018450:Disease Progression; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008954:Models, Biological; D040901:Proteomics / Q000379:methods
D000214:Acyl Coenzyme A; D002273:Carcinogens; D004041:Dietary Fats; D005227:Fatty Acids; D008055:Lipids
Histol Histopathol. 2007 Mar;22(3):251-60
17163399
World J Surg Oncol. 2009 Apr 01;7:36
19338662
EMBO Rep. 2009 Mar;10(3):271-7
19197340
Prostaglandins Leukot Essent Fatty Acids. 2008 Sep-Nov;79(3-5):93-6
18930643
Nature. 2009 Jan 22;457(7228):480-4
19043404
Mutat Res. 2009 Jul-Aug;682(1):39-53
19383551
Gastroenterol Clin North Am. 2002 Dec;31(4):925-43
12489270
Br J Nutr. 2007 May;97(5):872-82
17381980
Chem Soc Rev. 2009 Jul;38(7):1882-96
19551169
Nat Chem Biol. 2009 Sep;5(9):602-6
19690530
Ann Clin Lab Sci. 2007 Summer;37(3):213-21
17709684
J Nutr. 2007 Jan;137(1 Suppl):200S-204S
17182826
Anal Chem. 2006 Sep 1;78(17):6202-14
16944903
Neonatology. 2010;97(2):93-9
19707025
Nutr Hosp. 2006 May;21 Suppl 2:42-52, 44-54
16771072
Nat Rev Drug Discov. 2005 Jul;4(7):594-610
16052242
Cancer Res. 2008 Sep 15;68(18):7313-22
18794118
Am J Physiol Endocrinol Metab. 2009 Aug;297(2):E297-303
19126783
Carcinogenesis. 2009 Mar;30(3):377-86
19136477
Cancer Lett. 2006 Feb 28;233(2):297-308
15885896
Science. 2002 Mar 1;295(5560):1726-9
11872843
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15;877(26):2663
19640809
Cancer Res. 2008 Jul 1;68(13):4963-6
18593890
Cell. 1995 Jun 16;81(6):957-66
7781071
Mol Cell Biochem. 2009 Jun;326(1-2):23-8
19115050
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15;877(26):2736-45
19345647
Annu Rev Nutr. 1999;19:545-86
10448536
Sci STKE. 2006 Oct 31;2006(359):re14
17077383
Gastroenterology. 2002 Sep;123(3):862-76
12198712
Biochim Biophys Acta. 2006 Apr;1765(2):189-222
16487661
Methods Enzymol. 2007;432:117-43
17954215
Nat Rev Cancer. 2004 Jan;4(1):45-60
14681689
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Oct 1;877(27):2976-82
19646933
DNA Res. 2009 Feb;16(1):1-12
19147530
Pathol Res Pract. 2008;204(7):479-90
18538487
Annu Rev Pathol. 2009;4:343-64
19400693
Pathol Res Pract. 2005;201(2):83-91
15901128
Recent Results Cancer Res. 2005;166:177-211
15648191
J Clin Gastroenterol. 2006 Mar;40(3):235-43
16633129
World J Gastroenterol. 2007 Jul 28;13(28):3784-91
17657831
J Lipid Res. 2008 May;49(5):1113-25
18287618
J Pharmacol Sci. 2010;112(1):19-24
20093784
Int J Colorectal Dis. 2008 Aug;23(8):757-65
18458918
Methods. 2005 Jun;36(2):207-24
15894491
Mutat Res. 2010 Nov 10;693(1-2):32-45
19766128
Methods. 2006 Oct;40(2):191-7
17012032
Curr Opin Clin Nutr Metab Care. 2009 Sep;12(5):539-43
19512917
CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96
18287387
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15;877(26):2664-72
19286428
Anal Biochem. 2000 Oct 15;285(2):246-54
11017709
Anal Chem. 2008 Apr 15;80(8):2780-8
18314967
Cancer Chemother Pharmacol. 2009 Mar;63(4):571-82
19083000
J Lipid Res. 1978 Sep;19(7):916-21
712251
Lipids. 2008 Jan;43(1):79-89
18046593
Nat Rev Cancer. 2006 Jan;6(1):75-83
16372016
J Natl Cancer Inst. 1995 Feb 15;87(4):265-73
7707417
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 15;877(26):2836-46
19233743
Methods. 2006 Jun;39(2):82-91
16828308
FEMS Microbiol Lett. 2009 May;294(1):1-8
19222573
Biochim Biophys Acta. 2010 Mar;1801(3):240-5
19782151
Nature. 1962 Jan 6;193:63-4
14473351
Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):330-8
18268116
EMBO J. 2007 Jan 10;26(1):221-31
17159907
J Chromatogr B Biomed Sci Appl. 1997 Nov 21;702(1-2):21-32
9449552
Science. 2007 Nov 16;318(5853):1108-13
17932254
Methods Mol Biol. 2009;579:247-60
19763479
Best Pract Res Clin Gastroenterol. 2009;23(2):127-46
19414141
Gastroenterology. 2009 Aug;137(2):404-9
19540838
Gastroenterology. 2007 Aug;133(2):587-98
17681178
Methods. 2005 Jun;36(2):172-85
15896980