Therapeutics for cognitive aging.
This review summarizes the scientific talks presented at the conference "Therapeutics for Cognitive Aging," hosted by the New York Academy of Sciences and the Alzheimer's Drug Discovery Foundation on May 15, 2009. Attended by scientists from industry and academia, as well as by a number of lay people-approximately 200 in all-the conference specifically tackled the many aspects of developing therapeutic interventions for cognitive impairment. Discussion also focused on how to define cognitive aging and whether it should be considered a treatable, tractable disease.
Shineman
Diana W
DW
The Alzheimer's Drug Discovery Foundation, New York, NY 10019, USA.
Salthouse
Timothy A
TA
Launer
Lenore J
LJ
Hof
Patrick R
PR
Bartzokis
George
G
Kleiman
Robin
R
Luine
Victoria
V
Buccafusco
Jerry J
JJ
Small
Gary W
GW
Aisen
Paul S
PS
Lowe
David A
DA
Fillit
Howard M
HM
D000375:Aging / Q000473:pathology / Q000502:physiology*; D015415:Biomarkers / Q000032:analysis; D001923:Brain Chemistry / Q000502:physiology; D002986:Clinical Trials as Topic / Q000639:trends; D003071:Cognition / Q000502:physiology*; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D015897:Comorbidity; D006801:Humans; D009186:Myelin Sheath / Q000378:metabolism; D009474:Neurons / Q000473:pathology; D009490:Neurosecretory Systems / Q000503:physiopathology; D012307:Risk Factors
D015415:Biomarkers
Ann N Y Acad Sci. 2007 Feb;1097:54-7
17413010
J Neuroendocrinol. 2008 Jun;20(6):866-72
18513207
Science. 1997 Oct 17;278(5337):412-9
9334292
N Engl J Med. 2009 Jul 16;361(3):255-63
19605830
Brain Pathol. 2010 Mar;20(2):419-30
19725833
Am J Geriatr Pharmacother. 2008 Jun;6(2):100-18
18675769
Alzheimers Dement. 2007 Apr;3(2):122-5
18596894
Neuroimage. 2010 Jan 1;49(1):240-8
19703569
Alzheimers Res Ther. 2009 Jul 09;1(1):2
19674435
Neurosci Lett. 2009 Jul 24;458(3):140-3
19397951
Neuroimage. 2010 Jan 15;49(2):1190-9
19796691
Biochem Biophys Res Commun. 2004 May 7;317(3):703-7
15081397
Acta Neuropathol. 2009 Jul;118(1):5-36
19381658
PLoS One. 2008 Oct 02;3(10):e3329
18830410
Neuroscience. 2004;125(1):277-88
15051166
Neurobiol Aging. 1997 Sep-Oct;18(5):549-53
9390783
Neurobiol Aging. 2005 Mar;26(3):335-40
15639311
Horm Behav. 2008 Jun;54(1):7-17
17927990
J Comp Neurol. 2003 Aug 25;463(3):281-302
12820162
J Pharmacol Exp Ther. 2009 Feb;328(2):364-70
19023041
Lancet Neurol. 2008 Jun;7(6):476-7
18485312
J Neuroendocrinol. 2007 Oct;19(10):743-51
17850456
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13122-6
18765818
Mol Interv. 2004 Oct;4(5):285-95
15471911
Neurobiol Aging. 2011 Aug;32(8):1341-71
19775776
Neuropharmacology. 2007 Oct;53(5):588-600
17698153
Neuron. 2004 Sep 30;44(1):49-57
15450159
Neurobiol Aging. 2008 Sep;29(9):1296-307
17420070
J Nucl Med. 2009 Sep;50(9):1464-70
19690025
Med Hypotheses. 1993 Oct;41(4):334-40
8289698
Arch Neurol. 2001 Sep;58(9):1395-402
11559310
Lancet Neurol. 2008 Feb;7(2):161-72
18207114
Cereb Cortex. 2009 Oct;19(10):2248-68
19150923
Neuroepidemiology. 2007;29(1-2):125-32
17975326
Brain. 2007 Jul;130(Pt 7):1767-76
17522104
Aging Cell. 2007 Jun;6(3):275-84
17465981
Brain Res. 2006 Dec 18;1126(1):156-66
16919611
N Engl J Med. 2006 Dec 21;355(25):2652-63
17182990
Brain. 2009 May;132(Pt 5):1355-65
19339253
Neuroscience. 2003;117(3):577-92
12617964
Arch Gen Psychiatry. 2006 Jan;63(1):63-72
16389198
J Comp Neurol. 1990 Nov 1;301(1):55-64
1706358
Nature. 2004 Jun 24;429(6994):883-91
15190254
Trends Neurosci. 2004 Oct;27(10):607-13
15374672
J Comp Neurol. 1990 Nov 1;301(1):44-54
2127598
Lancet. 2005 Dec 17;366(9503):2112-7
16360788
Alzheimer Dis Assoc Disord. 2006 Jul-Sep;20(3 Suppl 2):S75-8
16917200
Cereb Cortex. 2003 Sep;13(9):950-61
12902394