title: Marine natural meroterpenes: synthesis and antiproliferative activity.
abstract: Meroterpenes are compounds of mixed biogenesis, isolated from plants, microorganisms and marine invertebrates. We have previously isolated and determined the structure for a series of meroterpenes extracted from the ascidian Aplidium aff. densum. Here, we demonstrate the chemical synthesis of three of them and their derivatives, and evaluate their biological activity on two bacterial strains, on sea urchin eggs, and on cancerous and healthy human cells.
authors.affiliation: Laboratoire de Chimie des Biomolécules et de l'Environnement EA4215, Université de Perpignan, Perpignan Cedex, France. levert@univ-perp.fr
authors.forename: Annabel
authors.initials: A
authors.lastname: Simon-Levert
authors.forename: Christophe
authors.initials: C
authors.lastname: Menniti
authors.forename: Laurent
authors.initials: L
authors.lastname: Soulère
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Genevière
authors.forename: Chantal
authors.initials: C
authors.lastname: Barthomeuf
authors.forename: Bernard
authors.initials: B
authors.lastname: Banaigs
authors.forename: Anne
authors.initials: A
authors.lastname: Witczak
mesh_terms: D045784:Abietanes / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D006873:Hydroquinones / Q000138:chemical synthesis / Q000494:pharmacology*; D012617:Sea Urchins; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000138:chemical synthesis / Q000494:pharmacology*; D014561:Urochordata / Q000737:chemistry*
chemical_list: D045784:Abietanes; D000900:Anti-Bacterial Agents; D001578:Benzopyrans; D006873:Hydroquinones; D013729:Terpenes; C547631:conicol; C550777:didehydroconicol; C505314:methoxyconidiol
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