Research advances of antimicrobial peptides and applications in food industry and agriculture.
Antimicrobial peptides (AMPs) are produced by a wide range of organisms and serve as their natural defenses against infection caused by bacteria, viruses and fungi. Because of the positively charge and amphipathic structure, AMPs kill target cells through diverse and complex mechanisms once in a target membrane and these special mechanisms are considered to be the critical factors for the less tendency of drug resistance development. Thus AMPs may become a new generation of promising antimicrobial agents in future anti-infection application. Additionally, AMPs can also be used in food industry and agriculture. On the basis of discussing the structural features, action mechanisms and sources, the applications of AMPs were reviewed in this paper, including in food industry, feedstuff, cultivation of disease-resistant transgenic plant, cultivation of transgenic animal, and aquaculture, especially the patented applications.
Meng
Shuo
S
Institute of Biochemical and Biotechnological Drugs, Shandong University, Jinan 250012, Shandong, P.R. China.
Xu
Huanli
H
Wang
Fengshan
F
D000383:Agriculture / Q000379:methods*; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D019649:Food Industry / Q000379:methods*; D006801:Humans; D012106:Research
D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides