title: A common neuronal response to alphaherpesvirus infection.
abstract: Alphaherpesviruses are a subfamily of the Herpesviridae that can invade the nervous system and establish either lytic or latent infections. The establishment of latent infection can occur only in neurons, indicating a unique virus-host interaction in these cells. Here, we compare results from seven microarray studies that focused on the host response of either neural tissue or isolated neurons to alphaherpesvirus infection. These studies utilized either herpes simplex virus type 1 or pseudorabies virus as the infectious agent. From these data, we have found common host responses spanning a variety of infection models in different species, with different herpesvirus strains, and during all phases of infection including lytic, latent, and reactivation. The repeated observation of transcriptional effects on these genes and gene families indicates their likely importance in host defenses or the viral infectious process. We discuss the possible role of these different genes and genes families in alphaherpesvirus infection.
authors.affiliation: Department of Molecular Biology and Princeton Neuroscience Institute, Princeton University, 314 Schultz Laboratory, Princeton, NJ 08544, USA.
authors.forename: Moriah L
authors.initials: ML
authors.lastname: Szpara
authors.forename: Oren
authors.initials: O
authors.lastname: Kobiler
authors.forename: Lynn W
authors.initials: LW
authors.lastname: Enquist
mesh_terms: D018138:Alphaherpesvirinae / Q000235:genetics / Q000276:immunology; D015967:Gene Expression Regulation, Viral / Q000276:immunology / Q000502:physiology; D006566:Herpesviridae Infections / Q000276:immunology* / Q000821:virology; D006801:Humans; D015213:Neuroimmunomodulation / Q000276:immunology* / Q000502:physiology; D015398:Signal Transduction / Q000276:immunology / Q000502:physiology
references.citation: J Virol. 2007 Jan;81(1):59-67
references.pmid: 16987965
references.citation: Rev Med Virol. 2008 Jan-Feb;18(1):35-51
references.pmid: 17992661
references.citation: Virology. 2001 Jul 20;286(1):119-24
references.pmid: 11448165
references.citation: Nat Rev Microbiol. 2005 Apr;3(4):281-94
references.pmid: 15806094
references.citation: J Neurovirol. 2004 Feb;10(1):12-20
references.pmid: 14982724
references.citation: J Virol. 2006 Jul;80(13):6345-56
references.pmid: 16775323
references.citation: Gene. 2007 Oct 15;401(1-2):46-60
references.pmid: 17707117
references.citation: J Virol. 2006 Jul;80(13):6534-52
references.pmid: 16775340
references.citation: Mol Cell Proteomics. 2009 Apr;8(4):805-15
references.pmid: 19098277
references.citation: Clin Microbiol Rev. 2004 Oct;17(4):942-64, table of contents
references.pmid: 15489356
references.citation: J Virol. 2004 Feb;78(4):1706-17
references.pmid: 14747536
references.citation: J Virol. 2007 Sep;81(17):9175-82
references.pmid: 17553869
references.citation: J Virol. 2003 Sep;77(17):9533-41
references.pmid: 12915567
references.citation: J Clin Invest. 2008 Oct;118(10):3470-7
references.pmid: 18769632
references.citation: J Gen Virol. 2005 Mar;86(Pt 3):527-533
references.pmid: 15722511
references.citation: Pain. 2005 Nov;118(1-2):97-111
references.pmid: 16213091
references.citation: J Virol. 2008 Oct;82(19):9689-99
references.pmid: 18653448
references.citation: J Virol. 2004 Feb;78(4):1675-84
references.pmid: 14747533
references.citation: Nat Rev Immunol. 2009 Sep;9(9):630-44
references.pmid: 19696767
references.citation: J Neurovirol. 2009 Apr;15(2):123-30
references.pmid: 19115128
references.citation: J Gen Virol. 2007 Aug;88(Pt 8):2101-2105
references.pmid: 17622610
references.citation: J Virol. 2008 Jan;82(2):999-1010
references.pmid: 17977977
references.citation: J Cell Biol. 2002 Sep 30;158(7):1251-62
references.pmid: 12356869
references.citation: Mol Vis. 2008 Jul 03;14:1209-21
references.pmid: 18615202
references.citation: J Virol. 2004 Dec;78(23):12964-74
references.pmid: 15542648
references.citation: Science. 2006 Oct 13;314(5797):308-12
references.pmid: 16973841
references.citation: J Biol Chem. 2006 Nov 10;281(45):34549-60
references.pmid: 16973624
references.citation: Cell Res. 2007 Jun;17(6):546-55
references.pmid: 17502875
references.citation: J Immunol. 2006 Dec 1;177(11):7497-504
references.pmid: 17114416
references.citation: Cell Physiol Biochem. 2007;20(6):687-702
references.pmid: 17982252
references.citation: J Virol. 2008 Sep;82(17):8605-18
references.pmid: 18596102
references.citation: J Virol. 2006 Jul;80(14):7159-68
references.pmid: 16809321
references.citation: Genome Biol. 2003;4(5):P3
references.pmid: 12734009
references.citation: Nat Rev Immunol. 2005 Jul;5(7):546-59
references.pmid: 15965491
references.citation: J Virol. 2006 Feb;80(4):1773-86
references.pmid: 16439534
references.citation: J Virol. 2009 Mar;83(5):2058-66
references.pmid: 18842724
references.citation: Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3466-70
references.pmid: 11248101
references.citation: Nucleic Acids Res. 2003 Jan 1;31(1):219-23
references.pmid: 12519986
references.citation: Cancer Res. 2006 Mar 1;66(5):2509-13
references.pmid: 16510565
references.citation: J Virol. 2003 Sep;77(17):9590-612
references.pmid: 12915572
references.citation: J Leukoc Biol. 2007 Apr;81(4):860-9
references.pmid: 17289800
references.citation: J Neurovirol. 1997 Jun;3(3):212-24
references.pmid: 9200069
references.citation: Nucleic Acids Res. 2007 Jan;35(Database issue):D26-31
references.pmid: 17148475
references.citation: Trends Microbiol. 2007 Sep;15(9):426-33
references.pmid: 17764949
references.citation: J Virol. 1990 Feb;64(2):941-3
references.pmid: 2153254
references.citation: Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3932-7
references.pmid: 11867761
references.citation: J Neuroimmunol. 1997 Sep;78(1-2):132-7
references.pmid: 9307237
references.citation: Nature. 1996 Sep 12;383(6596):172-5
references.pmid: 8774882
references.citation: J Virol. 2005 Oct;79(20):12893-904
references.pmid: 16188991
references.citation: J Neurosci. 2007 Feb 21;27(8):2081-90
references.pmid: 17314303
references.citation: J Virol. 2004 May;78(9):4847-65
references.pmid: 15078966
references.citation: Invest Ophthalmol Vis Sci. 2009 Jun;50(6):2855-61
references.pmid: 19151393
references.citation: Science. 2007 Sep 14;317(5844):1522-7
references.pmid: 17872438
references.citation: Arch Virol. 2008;153(7):1335-45
references.pmid: 18548318
references.citation: J Virol. 2004 Apr;78(7):3489-501
references.pmid: 15016872
references.citation: J Neurovirol. 2005 Aug;11(4):376-83
references.pmid: 16162480