Atropine-induced rhabdomyolysis: an uncommon and potentially fatal adverse drug reaction.
A 25 year old woman received daily injection of 0.6 mg atropine for seven days by the intra-venous route. In addition to fever, incomprehensible speech and alteration of sensorium she developed albuminuria, hemoglobinuria and myoglobinuria. A diagnosis of atropine-induced rhabdomyolysis was made on the basis of clinical presentations and investigations. Although, datura poisoning and intoxication with wild mushrooms are known to result in rhabdomyolysis, this can be considered to be the first case of atropine-induced rhabdomyolysis and myoglobinuria.
Akhtar
S
S
Department of Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India.
Rai
M K
MK
Dutta
T K
TK
Subrahmanyam
Dks
D
Adithan
C
C
D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D001285:Atropine / Q000009:adverse effects*; D064420:Drug-Related Side Effects and Adverse Reactions; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D012206:Rhabdomyolysis / Q000139:chemically induced*
D000889:Anti-Arrhythmia Agents; D001285:Atropine