Detection of inducible clindamycin resistance in beta-hemolytic streptococci by using the CLSI broth microdilution test and erythromycin-clindamycin combinations.
This study assessed an erythromycin-clindamycin (ERY-CC) broth test for inducible CC resistance in beta-hemolytic streptococci. One hundred one isolates of groups A, B, C, F, and G were tested by the CLSI broth microdilution method. Combinations of 1 and 0.25 microg/ml or 0.5 and 0.25 microg/ml of ERY and CC, respectively, detected all inducible isolates.
Bowling
Jason E
JE
Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA.
Owens
Aaron E
AE
McElmeel
M Leticia
ML
Fulcher
Letitia C
LC
Herrera
Monica L
ML
Wickes
Brian L
BL
Jorgensen
James H
JH
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004917:Erythromycin / Q000494:pharmacology*; D006460:Hemolysin Proteins / Q000378:metabolism; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D013291:Streptococcus / Q000187:drug effects* / Q000502:physiology; D015533:Transcriptional Activation
D000900:Anti-Bacterial Agents; D006460:Hemolysin Proteins; D002981:Clindamycin; D004917:Erythromycin
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