title: A fiberoptic reflectance probe with multiple source-collector separations to increase the dynamic range of derived tissue optical absorption and scattering coefficients.
abstract: Measurement of tissue optical absorption and (transport) reduced scattering coefficients (mu(a) and mu(s)', respectively) is fundamental to many applications of light in medicine and biology. We report a handheld fiberoptic probe to determine these coefficients by measuring the diffuse reflectance at multiple source-collector distances, which allows for a larger dynamic range than a single source-collector separation. Diffusion theory and a priori knowledge of the spectral shape of mu(a) and mu(s)' are used in a forward model of the diffuse reflectance. The dynamic range and accuracy of this method were evaluated using Monte Carlo simulations, phantom experiments and tissues in vivo.
authors.affiliation: Department of Medical Biophysics, University of Toronto and Ontario Cancer Institute/Campbell Family Institute for Cancer Research, University Health Network, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada.
authors.forename: Anthony
authors.initials: A
authors.lastname: Kim
authors.forename: Mathieu
authors.initials: M
authors.lastname: Roy
authors.forename: Farhan
authors.initials: F
authors.lastname: Dadani
authors.forename: Brian C
authors.initials: BC
authors.lastname: Wilson
mesh_terms: D003198:Computer Simulation; D004867:Equipment Design; D019544:Equipment Failure Analysis; D005336:Fiber Optic Technology / Q000295:instrumentation*; D008954:Models, Biological; D009391:Nephelometry and Turbidimetry / Q000295:instrumentation*; D010783:Photometry / Q000295:instrumentation*; D014159:Transducers