title: Synthesis, spectral characterization, and biological activity of some new substituted 10H-phenothiazines, its ribofuranosides, and sulfones.
abstract: This article describes the synthesis of new substituted 10 H-phenothiazines by Smiles rearrangement. These compounds are then used as a base to form ribofuranosides by treating them with a sugar (1-O-acetyl-2,3,5-tri-O-benzoyl-beta-ribofuranose). On oxidation with hydrogen peroxide in glacial acetic acid, these phenothiazines yield their sulfones. These compounds are screened for antioxidant and antimicrobial activity and their structure has been established by elemental analysis and spectroscopic data.
authors.affiliation: Department of Chemistry, L.B.S. Govt. P.G. College, Kotputli, Jaipur, India.
authors.forename: Naveen
authors.initials: N
authors.lastname: Gautam
authors.forename: Neha
authors.initials: N
authors.lastname: Ajmera
authors.forename: Shikha
authors.initials: S
authors.lastname: Gupta
authors.forename: D C
authors.initials: DC
authors.lastname: Gautam
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D004754:Enterobacter / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005663:Furans / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010640:Phenothiazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013210:Staphylococcus / Q000187:drug effects; D013237:Stereoisomerism; D013450:Sulfones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D000975:Antioxidants; D005663:Furans; D010640:Phenothiazines; D013450:Sulfones