title: Platelet function in rheumatoid arthritis: arthritic and cardiovascular implications.
abstract: Patients with rheumatoid arthritis (RA) are at high risk of cardiovascular events. Platelet biomarkers are involved in inflammation, atherosclerosis and thrombosis. Cardiovascular and RA-associated factors can alter the structure and function of platelets, starting from megakaryocytopoiesis. Reactive megakaryocytopoiesis increases circulating platelets count and triggers hyperactivity. Hyperactive platelets target synovial membranes with subsequent local rheumatoid inflammation. Hyperactive platelets interact with other cells, and target the vascular wall. Accumulating evidence suggests that disease modifying anti-rheumatic drugs (DMARD) decrease platelet activity.
authors.affiliation: Department of Rheumatology, Clinical Research Unit, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust (Teaching), Dudley DY1 2HQ, West Midlands, UK. a.gasparyan@gmail.com
authors.forename: Armen Yuri
authors.initials: AY
authors.lastname: Gasparyan
authors.forename: Antonios
authors.initials: A
authors.lastname: Stavropoulos-Kalinoglou
authors.forename: Dimitri P
authors.initials: DP
authors.lastname: Mikhailidis
authors.forename: Karen M J
authors.initials: KM
authors.lastname: Douglas
authors.forename: George D
authors.initials: GD
authors.lastname: Kitas
mesh_terms: D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000188:drug therapy / Q000378:metabolism*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D019013:CD40 Antigens / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D055252:Cell-Derived Microparticles / Q000378:metabolism; D006801:Humans; D019007:P-Selectin / Q000097:blood; D013927:Thrombosis / Q000378:metabolism
chemical_list: D018501:Antirheumatic Agents; D019013:CD40 Antigens; D019007:P-Selectin
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