Paramyxovirus assembly and budding: building particles that transmit infections.
The paramyxoviruses define a diverse group of enveloped RNA viruses that includes a number of important human and animal pathogens. Examples include human respiratory syncytial virus and the human parainfluenza viruses, which cause respiratory illnesses in young children and the elderly; measles and mumps viruses, which have caused recent resurgences of disease in developed countries; the zoonotic Hendra and Nipah viruses, which have caused several outbreaks of fatal disease in Australia and Asia; and Newcastle disease virus, which infects chickens and other avian species. Like other enveloped viruses, paramyxoviruses form particles that assemble and bud from cellular membranes, allowing the transmission of infections to new cells and hosts. Here, we review recent advances that have improved our understanding of events involved in paramyxovirus particle formation. Contributions of viral matrix proteins, glycoproteins, nucleocapsid proteins, and accessory proteins to particle formation are discussed, as well as the importance of host factor recruitment for efficient virus budding. Trafficking of viral structural components within infected cells is described, together with mechanisms that allow for the selection of specific sites on cellular membranes for the coalescence of viral proteins in preparation of bud formation and virion release.
Harrison
Megan S
MS
Department of Veterinary and Biomedical Sciences, and Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA 16802, United States.
Sakaguchi
Takemasa
T
Schmitt
Anthony P
AP
D000818:Animals; D006801:Humans; D018098:Paramyxovirinae / Q000378:metabolism / Q000502:physiology*; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*; D019065:Virus Assembly / Q000235:genetics / Q000502:physiology*; D057074:Virus Release / Q000235:genetics / Q000502:physiology*
D014764:Viral Proteins
J Virol. 2009 Oct;83(20):10374-83
19656884
Curr Top Microbiol Immunol. 2004;283:145-96
15298170
J Virol. 2007 Jul;81(13):7111-23
17475660
Virology. 2001 Dec 20;291(2):215-25
11878891
Virology. 2004 Oct 1;327(2):175-85
15351205
Virology. 1992 Apr;187(2):413-22
1312267
J Virol. 1992 May;66(5):3263-9
1560547
J Virol. 2001 Jun;75(11):5205-14
11333902
Vet Clin North Am Food Anim Pract. 2002 Nov;18(3):515-47, ix
12442581
J Virol. 2007 Jul;81(13):6827-36
17442724
J Virol. 1993 Oct;67(10):5902-10
8396659
J Virol. 2009 Aug;83(16):8191-7
19493999
Trends Microbiol. 2006 Jun;14(6):243-6
16678421
J Virol. 1993 Jan;67(1):407-14
8380086
J Virol. 2006 Nov;80(22):11062-73
16971425
Nat Rev Microbiol. 2006 Jan;4(1):23-35
16357858
Microbiol Mol Biol Rev. 2003 Jun;67(2):226-37, table of contents
12794191
Virus Res. 2005 Aug;111(2):132-47
15893837
Virology. 1995 Jun 1;209(2):701-7
7778306
J Virol. 2007 Apr;81(7):3187-97
17229713
Virology. 2007 Aug 15;365(1):101-12
17467023
J Gen Virol. 2005 Jul;86(Pt 7):1879-1884
15958665
J Virol. 2006 Nov;80(21):10652-62
17041223
J Virol. 2008 Oct;82(19):9730-8
18667490
J Virol. 2006 Dec;80(24):12070-8
17005661
Virology. 1995 Jun 20;210(1):91-9
7793085
Genes Cells. 2007 Apr;12(4):473-86
17397395
Annu Rev Cell Dev Biol. 2003;19:141-72
14570567
J Biol Chem. 2000 Jun 9;275(23):17221-4
10770957
Traffic. 2007 Oct;8(10):1297-303
17645437
J Virol. 2008 Sep;82(17):8664-72
18562526
Virology. 1975 Jul;66(1):185-91
166498
J Virol. 2001 Feb;75(3):1274-83
11152500
Virology. 1992 Aug;189(2):647-56
1322593
J Virol. 2009 Jun;83(11):5495-504
19297498
Cell. 1988 Oct 21;55(2):255-65
3167982
Virology. 1993 Aug;195(2):596-607
8337834
J Virol. 2001 Feb;75(3):1117-23
11152484
J Biol Chem. 2008 Apr 4;283(14):8783-7
18287095
Annu Rev Cell Dev Biol. 2004;20:395-425
15473846
Virology. 2000 Dec 5;278(1):111-21
11112487
J Gen Virol. 2007 Apr;88(Pt 4):1243-1250
17374768
J Gen Virol. 2007 Feb;88(Pt 2):570-581
17251576
J Virol. 1996 Aug;70(8):5067-74
8764014
Nucleic Acids Res. 2007;35(11):3602-11
17485480
Virology. 2004 Jul 20;325(1):1-10
15231380
J Gen Virol. 1996 Feb;77 ( Pt 2 ):327-38
8627237
FEMS Microbiol Rev. 2006 Sep;30(5):692-705
16911040
Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12978-83
14563923
Rev Sci Tech. 2000 Apr;19(1):160-5
11189713
J Mol Biol. 2000 Jun 30;300(1):103-12
10864502
J Gen Virol. 1978 May;39(2):219-29
650174
Virology. 2008 May 10;374(2):495-505
18252261
J Virol. 2005 Jul;79(14):9134-44
15994808
Cell Microbiol. 2007 May;9(5):1203-14
17217427
Virology. 1976 May;71(1):143-61
179199
Virology. 2006 Jan 5;344(1):55-63
16364736
Virology. 1988 Jan;162(1):255-9
3276076
Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13069-74
11087861
Proc Natl Acad Sci U S A. 1985 Feb;82(4):978-82
2983337
Virology. 2005 Jan 5;331(1):73-81
15582654
J Infect Dis. 1990 Mar;161(3):402-6
2155971
J Virol. 2007 Mar;81(5):2263-73
17166905
J Biol Chem. 1993 Oct 15;268(29):21924-30
8408048
J Virol. 1986 Feb;57(2):678-83
3003398
Virology. 2006 Aug 15;352(1):121-30
16716375
Virology. 2000 Oct 25;276(2):289-303
11040121
J Virol. 2009 Jul;83(14):7261-72
19439476
Science. 2009 Nov 27;326(5957):1279-83
19965480
J Virol. 2005 Jul;79(14):8933-41
15994787
J Virol. 2000 Jun;74(12):5619-28
10823869
Curr Top Microbiol Immunol. 2004;283:1-41
15298166
Curr Top Microbiol Immunol. 2004;283:61-119
15298168
Cell. 1983 Feb;32(2):559-67
6297799
J Virol. 2010 Mar;84(5):2294-303
20032189
J Virol. 2000 Nov;74(21):9911-5
11024118
J Virol. 1995 Apr;69(4):2667-73
7884920
J Virol. 1999 Oct;73(10):8703-12
10482624
J Virol. 1999 Apr;73(4):2921-9
10074141
J Virol. 2002 Jul;76(14):7174-86
12072517
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5071-5
283416
Virus Res. 2004 Dec;106(2):87-102
15567490
Virology. 1976 Jan;69(1):116-31
174287
Virus Res. 1989 Oct;14(2):175-87
2558461
Virology. 2007 Dec 20;369(2):309-23
17825340
J Gen Virol. 2002 Mar;83(Pt 3):611-621
11842256
Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13057-62
11087859
J Virol. 1974 Feb;13(2):298-304
4359296
Virology. 1992 Jun;188(2):910-5
1585658
J Virol. 2001 Feb;75(4):1984-9
11160698
J Virol. 2001 Nov;75(22):10623-9
11602704
J Virol. 1999 Apr;73(4):3359-65
10074190
J Virol. 2007 Apr;81(8):4158-65
17267508
Exp Cell Res. 2009 May 15;315(9):1619-26
19013455
J Virol. 1994 Nov;68(11):7386-96
7933122
J Virol. 1991 Nov;65(11):6296-300
1920633
Adv Virus Res. 2005;64:383-416
16139601
J Virol. 2005 Oct;79(19):12528-35
16160180
J Virol. 2002 Sep;76(18):9284-97
12186912
J Virol. 1999 Aug;73(8):7035-8
10400805
Virus Res. 2005 Mar;108(1-2):221-4
15681074
EMBO J. 2002 May 15;21(10):2364-72
12006489
J Virol. 1982 Jun;42(3):963-8
6285006
Virology. 2009 Mar 30;386(1):168-82
19178924
Rev Med Virol. 2009 Jan;19(1):31-45
18618839
EMBO J. 2000 Aug 15;19(16):4228-36
10944105
J Virol. 2004 May;78(10):5358-67
15113915
Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4441-6
19251668
J Virol. 2003 Feb;77(3):1812-9
12525615
Virology. 2000 May 10;270(2):464-75
10793005
Virology. 1998 Dec 5;252(1):137-48
9875324
J Virol. 1996 Sep;70(9):5990-7
8709221
Arch Virol. 2004 Jan;149(1):199-210
14689285
Biochemistry. 2005 Sep 27;44(38):12887-95
16171404
J Virol. 1998 Jun;72(6):5276-8
9573304
J Virol. 1993 Oct;67(10):5803-12
8396656
Virology. 1990 Jun;176(2):633-7
2161153
Arch Virol. 2003 Jul;148(7):1419-29
12827470
J Cell Biol. 2009 Apr 20;185(2):213-24
19380877
Virus Res. 2002 Feb 26;83(1-2):1-12
11864737
J Virol. 2005 May;79(10):6078-88
15857993
Vaccine. 1998 Nov;16(18):1775-8
9778756
J Virol. 2003 Dec;77(24):12968-79
14645553
Virology. 1986 Feb;149(1):91-106
3946081
EMBO J. 1997 Mar 17;16(6):1236-47
9135140
Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9
11413487
Proc Natl Acad Sci U S A. 2000 Dec 5;97(25):13871-6
11095724
Virus Res. 2003 Mar;92(1):89-98
12606080
Virology. 2003 Feb 15;306(2):254-67
12642099
J Virol. 1998 Feb;72(2):1224-34
9445022
Virol J. 2007 Jan 04;4:1
17204159
Pediatr Infect Dis J. 2001 Jul;20(7):646-53
11465835
Virology. 1979 Jan 15;92(1):139-54
217160
J Virol. 2009 Jun;83(11):5353-62
19297465
Genes Cells. 1998 Feb;3(2):111-24
9605405
Microbiol Immunol. 2005;49(9):835-44
16172538
Virology. 2008 Mar 15;372(2):221-32
18063004
J Gen Virol. 1994 May;75 ( Pt 5):1031-42
8176365
J Gen Virol. 1997 Sep;78 ( Pt 9):2335-9
9292023
J Virol. 2003 Jun;77(11):6419-29
12743299
J Virol. 2000 Jan;74(1):305-11
10590118
Virology. 2010 Feb 5;397(1):155-66
19932912
J Virol. 1999 Aug;73(8):6559-65
10400752
Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3974-9
18305167
Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10209-14
18621683
Biochem Biophys Res Commun. 2007 Apr 20;355(4):1096-101
17336269
EMBO J. 2000 Jul 17;19(14):3576-85
10899112
Virology. 2007 May 25;362(1):85-98
17250865
J Virol. 2005 Mar;79(5):2988-97
15709019
EMBO J. 1998 Jul 15;17(14):3899-908
9670007
J Virol. 2007 Mar;81(6):2861-8
17192312
Emerg Infect Dis. 2007 Jul;13(7):1031-7
18214175
J Gen Virol. 1991 Jul;72 ( Pt 7):1703-7
1649904
Eur J Biochem. 2004 Dec;271(23-24):4621-8
15606749
J Cell Biol. 2007 Nov 19;179(4):627-33
18025300
Virology. 2006 Jan 20;344(2):296-303
16229873
J Virol. 1998 Jul;72(7):5707-16
9621029
J Virol. 2006 Apr;80(8):4191-5
16571837
Nat Med. 2001 Dec;7(12):1313-9
11726971
FEBS Lett. 1999 Oct 8;459(2):205-10
10518019
J Virol. 2007 Oct;81(19):10636-48
17652393
N Engl J Med. 2009 Feb 5;360(6):588-98
19196675
J Virol. 2000 Nov;74(21):9818-27
11024108
J Virol. 2007 Apr;81(7):3264-71
17215288
Virus Res. 2004 Dec;106(2):133-45
15567493
Nature. 1997 Jun 5;387(6633):569-72
9177342
J Virol. 2001 Dec;75(23):11384-91
11689619
J Virol. 1980 Jan;33(1):152-66
6245225
J Virol. 2002 Apr;76(8):3952-64
11907235
Virol J. 2008 Nov 10;5:137
19000317
Virus Res. 2006 Sep;120(1-2):199-207
16621099
Curr Infect Dis Rep. 2006 Jan;8(1):59-65
16448602
J Virol. 2004 Mar;78(6):2657-65
14990685
J Pediatr. 2003 Nov;143(5 Suppl):S112-7
14615709
Virology. 2002 Sep 1;300(2):244-54
12350355
Virology. 2008 Feb 5;371(1):108-20
18028977