Chemokines and hepatocellular carcinoma.
Chemokines play a paramount role in tumor progression. In hepatocellular carcinoma (HCC) progression, chemokines and their receptors play an intricate role. Currently, chemokines and their receptors such as the CXCL12-CXCR4 axis, CX3CL1-CX3CR1 axis and the CCL20-CCR6 axis have received much research attention. Although a large number of studies show that these axes are strongly associated with HCC, the exact mechanism by which these axes promote the growth and progression of HCC remains unknown. In this paper, several chemokines and their receptor interactions in HCC progression, growth and metastasis and immune response to HCC are reviewed.
Huang
Fan
F
Department of Hepatobiliary Surgery of the First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China.
Geng
Xiao-Ping
XP
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D054418:Chemokine CCL20 / Q000378:metabolism; D054377:Chemokine CXCL12 / Q000378:metabolism; D018925:Chemokines / Q000378:metabolism*; D018450:Disease Progression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007107:Immune System; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D008954:Models, Biological; D009362:Neoplasm Metastasis; D054399:Receptors, CCR6 / Q000378:metabolism; D019718:Receptors, CXCR4 / Q000378:metabolism
D000970:Antineoplastic Agents; C108355:CCL20 protein, human; C106311:CCR6 protein, human; C515255:CXCL12 protein, human; C527276:CXCR4 protein, human; D054418:Chemokine CCL20; D054377:Chemokine CXCL12; D018925:Chemokines; D054399:Receptors, CCR6; D019718:Receptors, CXCR4
Br J Cancer. 2006 Jul 17;95(2):210-7
16819541
World J Gastroenterol. 2006 Nov 7;12(41):6627-33
17075975
J Gastroenterol Hepatol. 2006 Jan;21(1 Pt 1):161-8
16706828
Int J Biochem Cell Biol. 2007;39(1):197-205
16973405
World J Gastroenterol. 2008 Feb 7;14(5):713-9
18205260
Scand J Immunol. 2006 Jun;63(6):468-77
16764701
Biochem Biophys Res Commun. 2006 Nov 10;350(1):74-81
16989774
J Exp Med. 2001 Mar 19;193(6):F23-6
11257144
Hepatology. 2008 Sep;48(3):799-807
18570214
Gene Ther. 2007 Aug;14(16):1226-34
17597794
Am J Pathol. 2004 Dec;165(6):1969-77
15579440
Nature. 2002 Dec 19-26;420(6917):860-7
12490959
J Exp Clin Cancer Res. 2007 Dec;26(4):527-33
18365549
J Clin Invest. 1998 Aug 1;102(3):465-72
9691082
Oncol Rep. 2005 May;13(5):957-63
15809764
Cancer Lett. 1997 Nov 25;120(1):101-8
9570392
Int J Cancer. 2006 Apr 15;118(8):1869-76
16284949
Biochem Biophys Res Commun. 2004 Sep 24;322(3):1052-8
15336571
J Gastroenterol Hepatol. 2007 May;22(5):690-6
17444857
Lancet. 2001 Feb 17;357(9255):539-45
11229684
Mol Cancer Res. 2007 Jan;5(1):21-33
17259344
Mol Cancer Ther. 2007 Nov;6(11):2948-58
18025279
Am J Pathol. 2003 Apr;162(4):1249-58
12651617
J Hepatol. 2002 Jul;37(1):39-47
12076860
Cell Mol Immunol. 2008 Oct;5(5):373-8
18954561
Clin Chem Lab Med. 2009;47(4):412-8
19327121
Jpn J Cancer Res. 2002 Jul;93(7):789-97
12149145
Nutr Cancer. 2009;61(3):340-7
19373607
World J Gastroenterol. 2005 Jan 14;11(2):164-70
15633209
J Surg Oncol. 2007 Mar 1;95(3):241-9
17323338