[Cytokine synthesis in the healthy volunteer's blood mononuclear cells under the influence of an indolyl-thio-alkanecarboxylic acid derivative with selective immunosuppressant properties].
The influence of BM-7-02 compound on the production of cytokines in the culture of healthy volunteers' blood cells. This compound suppresses the production of main cytokine (gamma-IFN, IL-2 and IL-4) synthesized by CD4+ Th1 and Th2 cells, stimulates the production of TNF-alpha and IL-6, and does not change the production of IL-1 beta.
Gol'dina
I A
IA
Safronova
I V
IV
Gaĭdul'
K V
KV
Kozlov
V A
VA
D001782:Blood Donors; D016207:Cytokines / Q000097:blood*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000494:pharmacology*
D016207:Cytokines; D007166:Immunosuppressive Agents; D007211:Indoles; D013438:Sulfhydryl Compounds; C005732:thioacetic acid