Serum high-sensitivity C-reactive protein and homocysteine changes during hormonal therapy in women with polycystic ovary syndrome: a prospective, matched study.
The study evaluated the effect of 5 hormonal regimes on serum levels of high-sensitivity C-reactive protein (hsCRP) and homocysteine (Hcy) in women with polycystic ovary syndrome (PCOS). Women with PCOS received (1) conjugated estrogens and cyproterone acetate (n = 22), (2) 17beta-estradiol and cyproterone acetate (n = 17), (3) ethinyl-estradiol and cyproterone acetate (high dose; n = 20), (4) ethinyl-estradiol plus cyproterone acetate (low dose; n = 12), or (5) ethinyl-estradiol plus desogetrel (n = 12). Both hsCRP and Hcy levels were measured at baseline and after 4, 7, and 12 months. The 17beta-estradiol/cyproterone acetate regime resulted in significant reduction of both hsCRP and Hcy levels (P < .001). The other 4 regimes only resulted in a reduction of Hcy levels (P < .001). In conclusion, the 17beta-estradiol/cyproterone acetate regime had the most favorable effects in women with PCOS regarding serum levels of hsCRP and Hcy.
Makedos
Anastasios
A
Second Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, Greece. anmakedos@yahoo.gr
Goulis
Dimitrios G
DG
Papanikolaou
Alexis
A
Panidis
Dimitrios
D
D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism*; D017373:Cyproterone Acetate / Q000627:therapeutic use; D017135:Desogestrel / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D016014:Linear Models; D010641:Phenotype; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy*; D011446:Prospective Studies; D018709:Statistics, Nonparametric
D004966:Estrogens, Conjugated (USP); D006710:Homocysteine; D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate; D017135:Desogestrel; D002097:C-Reactive Protein