Annulated diketopiperazines from dipeptides or Schöllkopf reagents via tandem cyclization-intramolecular N-arylation.
Facile CuI-mediated N-arylation of diketopiperazine using the Fukuyama modification of the Ullmann-Goldberg reaction can be exploited in new approaches to enantiopure polycyclic diketopiperazines from easily assembled dipeptides or functionalized Schöllkopf reagents.
Lim
Hwan Jung
HJ
Department of Chemistry, The Ohio State University, 100 W. 18th Avenue, Columbus, Ohio 43210, USA.
Gallucci
Judith C
JC
RajanBabu
T V
TV
D003500:Cyclization; D054659:Diketopiperazines / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry*; D008958:Models, Molecular
D054659:Diketopiperazines; D004151:Dipeptides; D007202:Indicators and Reagents
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