title: When to screen children with Down syndrome for celiac disease?
abstract: The coexistence of Down syndrome (DS) and celiac disease (CD) has been reported in many studies. In our study, we examined 82 children with DS aged 8 months to 8.6 years for the existence of CD using serological markers immunoglobulin A (IgA) and immunoglobulin G (IgG) transglutaminase antibodies, followed by follow-up determination of total IgA levels. In four children who were positive for one of the above-mentioned antibodies, enteric biopsy has been performed that showed absence of CD. Our findings raise doubt about the need for obligatory serological screening of children with DS aged <8 years.
authors.affiliation: Department of Pediatrics, General Hospital Subotica, Izvorska 3, 24000 Subotica, Serbia. momodec@tippnet.rs
authors.forename: Momcilo
authors.initials: M
authors.lastname: Pavlovic
authors.forename: Nedeljko
authors.initials: N
authors.lastname: Radlovic
authors.forename: Zoran
authors.initials: Z
authors.lastname: Lekovic
authors.forename: Zorica
authors.initials: Z
authors.lastname: Stojsic
authors.forename: Katja
authors.initials: K
authors.lastname: Puleva
authors.forename: Karolina
authors.initials: K
authors.lastname: Berenji
mesh_terms: D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002446:Celiac Disease / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008297:Male; D015995:Prevalence; D055771:Serbia / Q000453:epidemiology; D011503:Transglutaminases / Q000097:blood*
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D011503:Transglutaminases