Genome-wide association studies in diverse populations.
Genome-wide association (GWA) studies have identified a large number of SNPs associated with disease phenotypes. As most GWA studies have been performed in populations of European descent, this Review examines the issues involved in extending the consideration of GWA studies to diverse worldwide populations. Although challenges exist with issues such as imputation, admixture and replication, investigation of a greater diversity of populations could make substantial contributions to the goal of mapping the genetic determinants of complex diseases for the human population as a whole.
Rosenberg
Noah A
NA
Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA. rnoah@umich.edu
Huang
Lucy
L
Jewett
Ethan M
EM
Szpiech
Zachary A
ZA
Jankovic
Ivana
I
Boehnke
Michael
M
D005828:Genetics, Population; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans
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