title: Association between mannose-binding lectin gene polymorphisms and pre-eclampsia in Brazilian women.
abstract: OBJECTIVE
  Mannose-binding lectin (MBL) is involved in the maintenance of an inflammatory environment in uterus. High MBL levels have been associated with successful pregnancies whereas low levels are involved in pre-eclampsia (PE) development. Here, we evaluated MBL2 gene polymorphisms in the structural and promoter regions addressing their association with PE.
  
  
  METHODS
  DNA samples from 162 control pregnant women and 157 pregnant PE women were genotyped and data compared with demographic and clinical characteristics.
  
  
  RESULTS
  High frequency of C and D alleles (related to low MBL levels) was observed in PE women when compared to controls (C: 0.08 versus 0.03, P = 0.006; D: 0.10 versus 0.05, P = 0.009). Grouping the MBL genotypes according to phenotype, a higher frequency of OO genotype was observed in PE women when compared to control women (0.15 versus 0.04, P = 0.007).
  
  
  CONCLUSIONS
  Our data suggest that women with genotypes associated with low MBL levels could be potential PE developers.
authors.affiliation: Department of Genetics, Federal University of Rio Grande do Sul, Porto Alegre, RS - Brazil
authors.forename: Priscila
authors.initials: P
authors.lastname: Vianna
authors.forename: Gabriela Kniphoff
authors.initials: GK
authors.lastname: Da Silva
authors.forename: Bruno Paiva
authors.initials: BP
authors.lastname: Dos Santos
authors.forename: Moisés Evandro
authors.initials: ME
authors.lastname: Bauer
authors.forename: Caroline Abrão
authors.initials: CA
authors.lastname: Dalmáz
authors.forename: Eliane
authors.initials: E
authors.lastname: Bandinelli
authors.forename: José Artur Bogo
authors.initials: JA
authors.lastname: Chies
mesh_terms: D000328:Adult; D001938:Brazil; D016009:Chi-Square Distribution; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005260:Female; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D037601:Mannose-Binding Lectin / Q000235:genetics* / Q000276:immunology; D016297:Mutagenesis, Site-Directed; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011225:Pre-Eclampsia / Q000235:genetics* / Q000276:immunology; D011247:Pregnancy; D011401:Promoter Regions, Genetic
chemical_list: D037601:Mannose-Binding Lectin; D004247:DNA