Pyrimidine-purine and pyrimidine heterodinucleosides synthesis containing a triazole linkage.
This article describes a synthetic route to generate two purine-pyrimidine and pyrimidine heterodinucleosides. Both microwave activated regioselective alkylation using hydride and copper-catalyzed-azide-alkyne-cycloaddition (CuAAC) were used in order to perform the synthesis.
Lucas
R
R
Faculte des Sciences et Techniques, Universite de Limoges, Laboratoire de Chimie des Substances Naturelles, Limoges, France.
Elchinger
P H
PH
Faugeras
P A
PA
Zerrouki
R
R
D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D009690:Nucleic Acid Conformation; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D011687:Purines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
D009841:Oligonucleotides; D011687:Purines; D011743:Pyrimidines; D014230:Triazoles; D003300:Copper; C030986:pyrimidine; C030985:purine