title: Discrete DNA sites regulate global distribution of meiotic recombination.
abstract: Homologous recombination is induced to high levels in meiosis, is initiated by Spo11-catalyzed DNA double-strand breaks (DSBs) and is clustered at hotspots that regulate its positioning in the genome. Recombination is required for proper chromosome segregation in meiosis and defects in its frequency or positioning cause chromosome mis-segregation and, consequently, congenital birth defects such as Down's syndrome. Therefore, elucidating how meiotic recombination is positioned is of fundamental and biomedical interest. Our integration of historical and contemporary advances in the field, plus the re-analysis of published microarray data on the genome-wide distribution of recombination supports a unifying model for such regulation. We posit that discrete DNA sequence motifs position and regulate essentially all recombination across the genome, in much the same way that DNA sites position and regulate transcription. Moreover, we illustrate the use of overlapping mechanisms for the regulation of transcription and meiotic recombination. Bound transcription factors induce histone modifications that position recombination at hotspots.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 West Markham Street (slot 516), Little Rock, AR 72205-7199, USA. wahlswaynep@uams.edu
authors.forename: Wayne P
authors.initials: WP
authors.lastname: Wahls
authors.forename: Mari K
authors.initials: MK
authors.lastname: Davidson
mesh_terms: D000818:Animals; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D042421:Histone Code; D006657:Histones / Q000737:chemistry; D006801:Humans; D008540:Meiosis; D011995:Recombination, Genetic; D012045:Regulatory Sequences, Nucleic Acid
chemical_list: D006657:Histones; D004247:DNA
references.citation: J Mol Biol. 1988 Dec 20;204(4):917-25
references.pmid: 3221399
references.citation: Eukaryot Cell. 2007 Nov;6(11):2072-80
references.pmid: 17827346
references.citation: Mol Cell Biol. 1995 Mar;15(3):1679-88
references.pmid: 7862159
references.citation: Mol Cell. 2002 Apr;9(4):847-55
references.pmid: 11983175
references.citation: Curr Biol. 2007 Dec 4;17(23):2003-12
references.pmid: 18060788
references.citation: Genetics. 2009 Jun;182(2):459-69
references.pmid: 19363124
references.citation: Proc Natl Acad Sci U S A. 1993 Jul 15;90(14):6621-5
references.pmid: 8341678
references.citation: EMBO J. 2004 May 5;23(9):1957-67
references.pmid: 15071505
references.citation: PLoS Genet. 2009 Dec;5(12):e1000753
references.pmid: 19997497
references.citation: EMBO J. 1998 Jul 15;17(14):4147-57
references.pmid: 9670029
references.citation: Nature. 2007 Oct 18;449(7164):851-61
references.pmid: 17943122
references.citation: PLoS Genet. 2007 Aug;3(8):e141
references.pmid: 17722984
references.citation: Mol Cell Biol. 2006 Feb;26(3):1014-27
references.pmid: 16428454
references.citation: Curr Genet. 1992 Feb;21(2):109-16
references.pmid: 1568254
references.citation: Genetics. 1971 Nov;69(3):317-37
references.pmid: 17248549
references.citation: Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3955-60
references.pmid: 17360459
references.citation: Annu Rev Genet. 1999;33:603-754
references.pmid: 10690419
references.citation: Mol Cell Biol. 1991 Jan;11(1):289-98
references.pmid: 1986226
references.citation: Mol Biol Cell. 2008 Mar;19(3):1162-73
references.pmid: 18199689
references.citation: Cell. 1990 Jan 12;60(1):95-103
references.pmid: 2295091
references.citation: Mol Cell Biol. 1997 Dec;17(12):7008-18
references.pmid: 9372932
references.citation: Nature. 2008 Jul 24;454(7203):479-85
references.pmid: 18615017
references.citation: Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7446-51
references.pmid: 9207111
references.citation: Science. 2010 Feb 12;327(5967):876-9
references.pmid: 20044541
references.citation: EMBO J. 2009 Jan 21;28(2):99-111
references.pmid: 19078966
references.citation: Nature. 2002 Feb 21;415(6874):871-80
references.pmid: 11859360
references.citation: Genes Dev. 1994 Jul 15;8(14):1693-702
references.pmid: 7958849
references.citation: Genetics. 2005 Apr;169(4):1973-83
references.pmid: 15716492
references.citation: Bioessays. 2006 Jan;28(1):45-56
references.pmid: 16369948
references.citation: Proc Natl Acad Sci U S A. 1991 Nov 1;88(21):9755-9
references.pmid: 1946399
references.citation: Proc Natl Acad Sci U S A. 1966 Oct;56(4):1177-83
references.pmid: 5230143
references.citation: Cell. 2004 Aug 20;118(4):439-52
references.pmid: 15315757
references.citation: PLoS Genet. 2007 Jun;3(6):e100
references.pmid: 17590084
references.citation: Genetics. 1995 Jun;140(2):469-78
references.pmid: 7498729
references.citation: Nat Genet. 2008 Sep;40(9):1124-9
references.pmid: 19165926
references.citation: Nucleic Acids Res. 2008 May;36(9):2838-51
references.pmid: 18375981
references.citation: Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11383-90
references.pmid: 11027339
references.citation: EMBO J. 1991 Mar;10(3):681-6
references.pmid: 2001681
references.citation: Mol Cell Biol. 1998 Dec;18(12):7575-83
references.pmid: 9819443
references.citation: Mol Cell Biol. 2005 Oct;25(20):9054-62
references.pmid: 16199881
references.citation: Proc Natl Acad Sci U S A. 2004 Aug 3;101(31):11380-5
references.pmid: 15280549
references.citation: Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13765-70
references.pmid: 9391101
references.citation: EMBO J. 1991 Aug;10(8):2157-63
references.pmid: 2065658
references.citation: Mol Cell Biol. 1991 Jan;11(1):322-8
references.pmid: 1986228
references.citation: DNA Repair (Amst). 2008 Aug 2;7(8):1298-308
references.pmid: 18515193
references.citation: EMBO J. 2004 Apr 21;23(8):1792-803
references.pmid: 14988732
references.citation: Science. 2010 Feb 12;327(5967):836-40
references.pmid: 20044539
references.citation: Hum Mol Genet. 2007 Oct 15;16 Spec No. 2:R203-8
references.pmid: 17911163
references.citation: EMBO J. 2009 Sep 2;28(17):2616-24
references.pmid: 19644444
references.citation: PLoS One. 2009;4(5):e5533
references.pmid: 19436749
references.citation: PLoS One. 2008 Aug 06;3(8):e2887
references.pmid: 18682829
references.citation: PLoS Biol. 2007 Dec;5(12):e324
references.pmid: 18076285
references.citation: J Biol Chem. 2004 Dec 3;279(49):50857-63
references.pmid: 15448137