title: Synthesis and antitumor activity of novel 2',3'-diethanethio-2',3',5'-trideoxy-5'-triazolonucleoside analogues.
abstract: A series of novel 2',3'-diethanethio-2',3',5'-trideoxy-5'-triazoloribonucleosides was synthesized in excellent yields and their antitumor activity was evaluated. These nucleoside analogues with aromatic substituted triazole rings showed significantly improved activity towards a broad range of tumor cell lines and those without arene substitutes were inactive.
authors.affiliation: Department of Applied Chemistry and Pharmacy, Beijing Institute of Technology, Nandajie 5, Beijing 100081, P.R. China.
authors.forename: Jin-Lan
authors.initials: JL
authors.lastname: Yu
authors.forename: Qin-Pei
authors.initials: QP
authors.lastname: Wu
authors.forename: Qing-Shan
authors.initials: QS
authors.lastname: Zhang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Xi
authors.forename: Ning-Ning
authors.initials: NN
authors.lastname: Liu
authors.forename: Yun-Zheng
authors.initials: YZ
authors.lastname: Li
authors.forename: Yan-Hong
authors.initials: YH
authors.lastname: Liu
authors.forename: Hong-Quan
authors.initials: HQ
authors.lastname: Yin
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D009705:Nucleosides