title: Mendelian disorders and multifactorial traits: the big divide or one for all?
abstract: For the past century, Mendelian and multifactorial traits have existed at opposite ends of the disease spectrum in humans. Furthermore, the recent emphasis on genome-wide association studies for uncovering variants that underlie common diseases has risked deepening the divide - or has it? Four experienced human geneticists express their views on the changing landscape of human disease studies and the impact of new technologies and study designs on the age-old aim of connecting a genomic variant with its phenotypic consequences.
authors.affiliation: Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland. Stylianos.Antonarakis@unige.ch
authors.forename: Stylianos E
authors.initials: SE
authors.lastname: Antonarakis
authors.forename: Aravinda
authors.initials: A
authors.lastname: Chakravarti
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Cohen
authors.forename: John
authors.initials: J
authors.lastname: Hardy
mesh_terms: D000818:Animals; D004194:Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D020412:Multifactorial Inheritance
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