title: Applications of elastin-like polypeptides in tissue engineering.
abstract: Elastin-like polypeptides (ELPs) have found utility in tissue engineering applications, not only because they are biocompatible, biodegradable, and non-immunogenic, but also because their amino acid sequence and molecular weight can be precisely controlled at the genetic or synthetic level, affording exquisite control over final protein functionality. This review presents a basic overview of ELP properties and modifications that are relevant to tissue engineering, as well as a discussion of the application of ELPs to cartilage, intervertebral disc, vascular graft, liver, ocular, and cell sheet engineering.
authors.affiliation: Department of Biomedical Engineering, Durham, NC 27708, USA.
authors.forename: Dana L
authors.initials: DL
authors.lastname: Nettles
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Chilkoti
authors.forename: Lori A
authors.initials: LA
authors.lastname: Setton
mesh_terms: D004549:Elastin / Q000737:chemistry*; D006801:Humans; D010455:Peptides / Q000737:chemistry*; D023822:Tissue Engineering / Q000379:methods*
chemical_list: D010455:Peptides; D004549:Elastin
references.citation: Biomaterials. 2005 Aug;26(23):4695-706
references.pmid: 15763249
references.citation: Biomaterials. 2006 Jan;27(1):91-9
references.pmid: 16023192
references.citation: Biomaterials. 1992;13(13):905-14
references.pmid: 1477259
references.citation: Biomaterials. 2003 Oct;24(23):4245-52
references.pmid: 12853256
references.citation: Biomaterials. 2004 Mar-Apr;25(7-8):1261-7
references.pmid: 14643600
references.citation: Nat Biotechnol. 1999 Nov;17(11):1112-5
references.pmid: 10545920
references.citation: J Mater Sci Mater Med. 2004 Apr;15(4):479-84
references.pmid: 15332621
references.citation: Science. 1993 May 14;260(5110):920-6
references.pmid: 8493529
references.citation: Biomaterials. 2008 Feb;29(6):625-32
references.pmid: 18006054
references.citation: Biomacromolecules. 2005 Jan-Feb;6(1):318-23
references.pmid: 15638535
references.citation: Biomaterials. 1990 Nov;11(9):738-45
references.pmid: 2090313
references.citation: J Biomed Mater Res. 1992 Mar;26(3):393-413
references.pmid: 1613028
references.citation: Tissue Eng. 2005 Nov-Dec;11(11-12):1768-79
references.pmid: 16411822
references.citation: N Engl J Med. 1981 Mar 5;304(10):566-79
references.pmid: 7005671
references.citation: Biomacromolecules. 2008 Jan;9(1):222-30
references.pmid: 18163573
references.citation: Biomacromolecules. 2003 May-Jun;4(3):572-80
references.pmid: 12741772
references.citation: J Orthop Res. 1995 Jul;13(4):473-82
references.pmid: 7674064
references.citation: Adv Drug Deliv Rev. 2002 Oct 18;54(8):1075-91
references.pmid: 12384308
references.citation: Biomacromolecules. 2009 Aug 10;10(8):2183-8
references.pmid: 19722557
references.citation: Pharm Res. 2008 Mar;25(3):692-9
references.pmid: 17404809
references.citation: Biomacromolecules. 2008 Nov;9(11):2984-8
references.pmid: 18826275
references.citation: Acta Biomater. 2008 Jul;4(4):827-37
references.pmid: 18178532
references.citation: Biomaterials. 2007 Feb;28(6):1191-7
references.pmid: 17087991
references.citation: Acta Biomater. 2010 Jun;6(6):2108-15
references.pmid: 20026437
references.citation: Biotechnol Prog. 1990 May-Jun;6(3):198-202
references.pmid: 1366613
references.citation: Instr Course Lect. 1983;32:349-70
references.pmid: 6085932
references.citation: Biomacromolecules. 2002 Sep-Oct;3(5):910-6
references.pmid: 12217035
references.citation: Tissue Eng Part A. 2008 Jul;14(7):1133-40
references.pmid: 18433311
references.citation: Biomacromolecules. 2000 Spring;1(1):23-30
references.pmid: 11709838
references.citation: Biomacromolecules. 2007 May;8(5):1463-70
references.pmid: 17411091
references.citation: Biomacromolecules. 2001 Spring;2(1):170-9
references.pmid: 11749169
references.citation: J Biomater Sci Polym Ed. 2008;19(6):785-99
references.pmid: 18534097
references.citation: Adv Mater. 2009 Sep 4;21(32-33):3330-42
references.pmid: 20882500
references.citation: J Biomed Mater Res B Appl Biomater. 2008 Jul;86(1):283-90
references.pmid: 18161837
references.citation: Tissue Eng Part A. 2010 Jan;16(1):11-20
references.pmid: 19754250
references.citation: Biomaterials. 2006 Mar;27(9):1930-5
references.pmid: 16278015
references.citation: Curr Eye Res. 2009 Jan;34(1):48-56
references.pmid: 19172470