title: The first diastereoselective synthesis of cinerins A-C, PAF-antagonistic macrophyllin-type bicyclo[3.2.1]octane neolignans, using a novel Pd-catalysed oxyarylation.
abstract: The first diastereoselective synthesis of PAF-antagonistic cinerins A-C, macrophyllin-type bicyclo[3.2.1]octane neolignans from Pleurothyrium cinereum, has been accomplished using a novel Pd-catalysed oxyarylation to afford a 2,3-dihydrobenzofuran as the key intermediate.
authors.affiliation: Universidad Nacional de Colombia, Facultad de Ciencias, Departamento de Química, Laboratorio de Investigación en Productos Naturales Vegetales, AA 14490, Cra 30 45-03, Bogotá, D.C., Colombia. edcoyb@unal.edu.co
authors.forename: Ericsson D
authors.initials: ED
authors.lastname: Coy B
authors.forename: Luis E
authors.initials: LE
authors.lastname: Cuca S
authors.forename: Michael
authors.initials: M
authors.lastname: Sefkow
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry; D002384:Catalysis; D019770:Lauraceae / Q000737:chemistry; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D013237:Stereoisomerism
chemical_list: D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D017705:Lignans; D010972:Platelet Activating Factor; C550759:cinerin A; C550760:cinerin B; C550761:cinerin C; D010165:Palladium