title: Prenatal diagnosis and management of intrauterine fracture.
abstract: Intrauterine fracture is an extremely rare finding, but can occur as the result of maternal trauma, osteogenesis imperfecta (OI), or theoretically other metabolic/structural abnormalities. Increased clinical awareness of the diagnosis and optimal management of these cases can lead to more positive outcomes for the patient and her child. Blunt abdominal trauma late in gestation increases the risk of fetal skull fracture, while a known diagnosis of OI or other abnormalities leading to decreased fetal bone density creates concern for long bone fracture. Biochemical and genetic tests can aid in the prenatal diagnosis of OI, while ultrasound is the best overall imaging modality for identifying fetal fracture of any etiology. When fetal fracture is diagnosed radiologically, specific management is recommended to promote optimal outcomes for mother and fetus, with special consideration given to the mother with OI. With the exception of fetal fractures due to lethal conditions, cesarean delivery is recommended in most cases, especially when fetal or maternal well-being cannot be assured. When a patient presents with risk factors for intrauterine fracture, careful evaluation via thorough history-taking, ultrasonography of the entire fetal skeleton, and laboratory tests should be performed. Heightened awareness of intrauterine fracture allows better postpartum management, whether for simple fracture care or for long-term care of patients with OI or genetic/metabolic abnormalities.
  
  
  BACKGROUND
  Obstetricians & Gynecologist, Family Physicians.
  
  
  OBJECTIVE
  After completion of this educational activity, the reader will be able to compare x-ray, ultrasound modalities and MRI and their utility in diagnosing fetal fracture. Formulate a differential diagnosis for fetal fracture. Propose a delivery plan for a patient whose fetus has a prenatally diagnosed fetal fracture.
authors.affiliation: Department of Orthopaedic Surgery & Sports Medicine, Mayo Clinic, Rochester, MN 55905, USA. Morgan.Joseph@mayo.edu
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Morgan
authors.forename: Peter S
authors.initials: PS
authors.lastname: Marcus
mesh_terms: D002585:Cesarean Section; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000628:therapy; D050723:Fractures, Bone / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000628:therapy; D011296:Prenatal Diagnosis / Q000379:methods