title: Reduced expression of PTEN protein and its prognostic significance in the gastrointestinal stromal tumor.
abstract: Little is reported about the role of PTEN gene in the progression and prognosis of GISTs. This study examined the clinical implications of the tumor suppressor gene PTEN as a prognostic factor in the GISTs. Immunohistological staining and immunoblotting were employed to examine the PTEN protein expression, and its association with clinical measures. Clinicopathological features were reviewed by a retrospective examination of medical records. Reduced PTEN expression was significantly associated with tumor diameter, mitotic figure count, metastasis and pathological stage of tumor (P<0.05), and was not correlated with age, gender and tumor location (P>0.05). The 3-year survival rate of the patients with reduced PTEN expression was significantly lower than those with high PTEN expression (P<0.01). These results suggest that the expression of PTEN gene was significantly linked with the progression and metastasis of GISTs and it is an independent prognostic factor.
authors.affiliation: Tongji Cancer Research Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. yonghong_zhang@qq.com
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Dongdong
authors.initials: D
authors.lastname: Yu
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Li
authors.forename: Junbo
authors.initials: J
authors.lastname: Hu
authors.forename: Jianping
authors.initials: J
authors.lastname: Gong
mesh_terms: D000368:Aged; D015536:Down-Regulation; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000378:metabolism*; D046152:Gastrointestinal Stromal Tumors / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D011379:Prognosis
chemical_list: D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
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