title: Dysfunction of the magnocellular stream in Alzheimer's disease evaluated by pattern electroretinograms and visual evoked potentials.
abstract: BACKGROUND
  Visuo-spatial disturbances could represent a clinical feature of early stage Alzheimer's disease (AD). The magnocellular (M) pathway has anatomo-physiological characteristic which make it more suitable for detecting form, motion and depth compared with parvocellular one (P).
  
  
  OBJECTIVE
  Aim of our study was to evaluate specific visual subsystem involvement in a group of AD patients, recording isoluminant chromatic and luminance pattern electroretinograms and pattern visual evoked potentials.
  
  
  METHODS
  data were obtained from 15 AD patients (9 females and 6 males, mean age+/-1SD: 77.6+/-4.01 years) not yet undergoing any treatment, and from 10 age-matched healthy controls. Diagnosis of probable AD was clinically and neuroradiologically established. PERGs were recorded monocularly in response to equiluminant red-green (R-G), blue-yellow (B-Y) and luminance yellow-black (Y-Bk) horizontal square gratings of 0.3c/deg and 90% contrast, reversed at 1Hz. VEPs were recorded in response to full-field (14 deg) equiluminant chromatic R-G, B-Y and luminance Y-Bk sinusoidal gratings of 2c/deg, presented in onset (300ms)-offset (700ms) mode, at the contrast levels of 90%.
  
  
  RESULTS
  All data were retrieved in terms of peak-amplitude and latency and assessed using the Student's t-test for paired data. Temporal differences of PERGs and VEPs, evoked by Y-Bk grating in AD patients compared with controls, suggest a specific impairment of the magnocellular stream.
  
  
  CONCLUSIONS
  Our study support the hypothesis that the impairment of the PERGs and VEPs arising from the magnocellular streams of visual processing may indicate a primary dysfunction of the M-pathways in AD.
authors.affiliation: Department of Neuroscience, Unit of Neurology, Pisa University Medical School, Pisa, Italy. f.sartucci@neuro.med.unipi.it
authors.forename: F
authors.initials: F
authors.lastname: Sartucci
authors.forename: D
authors.initials: D
authors.lastname: Borghetti
authors.forename: T
authors.initials: T
authors.lastname: Bocci
authors.forename: L
authors.initials: L
authors.lastname: Murri
authors.forename: P
authors.initials: P
authors.lastname: Orsini
authors.forename: V
authors.initials: V
authors.lastname: Porciatti
authors.forename: N
authors.initials: N
authors.lastname: Origlia
authors.forename: L
authors.initials: L
authors.lastname: Domenici
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology*; D000818:Animals; D004596:Electroretinography / Q000379:methods*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D005260:Female; D005829:Geniculate Bodies / Q000503:physiopathology*; D006801:Humans; D008297:Male; D010775:Photic Stimulation; D014795:Visual Pathways / Q000503:physiopathology*; D014796:Visual Perception
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