[Effect of homocysteine on the structure and functions of human placenta trophoblasts].
Elevated level of homocysteine in blood serum of pregnant women is the risk factor for placental malfunction and fetal abnormalities. Our study has shown the activation of apoptosis, inhibition of proliferation, destruction of placental trophoblast and activation of the transsulfuration pathway under elevated homocysteine level in the incubation medium in the range of 20-80 microM. The activation of the transsulfuration pathway indicates that placenta may to some extent withstand elevated homocysteine level.
Martseniuk
O P
OP
Romanets'
K L
KL
Obolens'ka
M Iu
MIu
Huppertz
B
B
D017209:Apoptosis / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D003541:Cystathionine beta-Synthase / Q000235:genetics / Q000378:metabolism; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D006710:Homocysteine / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D008856:Microscopy, Fluorescence; D009924:Organ Culture Techniques; D010920:Placenta / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure; D011247:Pregnancy; D011264:Pregnancy Trimesters; D013455:Sulfur / Q000378:metabolism; D014327:Trophoblasts / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000648:ultrastructure
D006710:Homocysteine; D013455:Sulfur; D003541:Cystathionine beta-Synthase