Gender differences of low-dose aspirin-associated gastroduodenal ulcer in Japanese patients.
OBJECTIVE
To clarify the gender differences about the clinical features and risk factors of low-dose aspirin (LDA) (81-100 mg daily)-associated peptic ulcer in Japanese patients.


METHODS
There were 453 patients under treatment with LDA (298 males, 155 females) who underwent esophagogastroduodenoscopy at the Department of Gastroenterology and Hepatology of Hiratsuka City Hospital between January 2003 and December 2007. They had kept taking the LDA or started treatment during the study period and kept taking LDA during the whole period of observation. Of these, 119 patients (87 males, 32 females) were diagnosed as having LDA-associated peptic ulcer. We examined the clinical factors associated with LDA-associated peptic ulcer in both sexes.


RESULTS
A history of peptic ulcer was found to be the risk factor for LDA-associated peptic ulcer common to both sexes. In female patients, age greater than 70 years (prevalence ORs 8.441, 95% CI: 1.797-33.649, P = 0.0069) was found to be another significant risk factor, and the time to diagnosis as having LDA-associated peptic ulcer by endoscopy was significantly shorter than that in the male patients (P = 0.0050).


CONCLUSIONS
We demonstrated gender differences about the clinical features and risk factors of LDA-associated peptic ulcer. Special attention should be paid to aged female patients taking LDA.
Okada
Kazuhisa
K
Department of Gastroenterology and Hepatology, Hiratsuka City Hospital, 1-19-1, Nanbara, Hiratsuka 254-0066, Japan.
Inamori
Masahiko
M
Imajyo
Kento
K
Chiba
Hideyuki
H
Nonaka
Takashi
T
Shiba
Tadahiko
T
Sakaguchi
Takashi
T
Atsukawa
Kazuhiko
K
Takahashi
Hisao
H
Hoshino
Etsuo
E
Nakajima
Atsushi
A
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000009:adverse effects*; D004724:Endoscopy / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D010437:Peptic Ulcer / Q000175:diagnosis / Q000209:etiology*; D012307:Risk Factors; D012737:Sex Factors
D001241:Aspirin
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