Kaposiform (spindle cell) hemangioendotelioma in a child with an unusual presentation.
We describe a male child with multifocal kaposiform hemangioendothelioma in the right and left cervical region with development of Kasabach-Merritt syndrome. Treatment with interferon-alpha resulted in a good but only temporary clinical response.He relapsed 3 times with regrowth of the right cervical tumor. Involvement of the liver is suspected, because normalization of the liver size followed after the treatment with interferon-alpha. The question remains whether the multiple osteolytic bone lesions also reflect kaposiform hemangioendothelioma localization.
Veening
Margreet A
MA
Department of Pediatric Oncology-Hematology, VU University Medical Center, Amsterdam, The Netherlands. ma.veening@vumc.nl
Verbeke
Jonathan I
JI
Witbreuk
Melinda M
MM
Kaspers
Gert-Jan L
GJ
D000970:Antineoplastic Agents / Q000627:therapeutic use; D002648:Child; D006390:Hemangioendothelioma / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000188:drug therapy; D011379:Prognosis; D011994:Recombinant Proteins; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D013577:Syndrome
D000970:Antineoplastic Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins