title: All azoospermic males should be screened for cystic fibrosis mutations before intracytoplasmic sperm injection.
abstract: We assessed the frequency of CFTR mutations in groups with varying degrees of sub-fertility and compared these groups to a fertile male group with proven paternity. Screening for CFTR mutations should be routine for all azoospermic males, irrespective of obstructive or non-obstructive etiology, prior to proposing ICSI treatment. CFTR testing has no value in the investigation of non-azoospermic infertile males.
authors.affiliation: Human Assisted Reproduction Ireland, Rotunda Hospital, and Royal College of Surgeons in Ireland, Dublin, Ireland. emocanu@rcsi.ie
authors.forename: Edgar
authors.initials: E
authors.lastname: Mocanu
authors.forename: Richard
authors.initials: R
authors.lastname: Shattock
authors.forename: David
authors.initials: D
authors.lastname: Barton
authors.forename: Melissa
authors.initials: M
authors.lastname: Rogers
authors.forename: Ronan
authors.initials: R
authors.lastname: Conroy
authors.forename: Orla
authors.initials: O
authors.lastname: Sheils
authors.forename: Claire
authors.initials: C
authors.lastname: Collins
authors.forename: Cara
authors.initials: C
authors.lastname: Martin
authors.forename: Robert
authors.initials: R
authors.lastname: Harrison
authors.forename: John
authors.initials: J
authors.lastname: O'Leary
mesh_terms: D053713:Azoospermia / Q000175:diagnosis* / Q000235:genetics* / Q000628:therapy; D016022:Case-Control Studies; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000235:genetics*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics*; D004252:DNA Mutational Analysis; D005787:Gene Frequency; D006580:Genetic Carrier Screening; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000235:genetics / Q000628:therapy; D008297:Male; D009154:Mutation; D011237:Predictive Value of Tests; D011379:Prognosis; D020554:Sperm Injections, Intracytoplasmic
chemical_list: D019005:Cystic Fibrosis Transmembrane Conductance Regulator