title: Nuclear translocation of nuclear factor Kappa B in first trimester deciduas and chorionic villi in early spontaneous miscarriage women.
abstract: The nuclear factor kappa B is widely expressed in the distinct subpopulations of chorionic villi and deciduas of first-trimester pregnancies. We examined the cellular distribution and expression of nuclear factor kappa B in the human first-trimester chorionic villi and deciduas of women with early spontaneous miscarriage and viable pregnancy by confocal laser scanning microscope and immunohistochemistry. There is a greater nuclear translocation of nuclear factor kappa B is restricted to villous stromal cells, decidual stromal cells, glandular epithelial cells and vessel endothelial cells in early spontaneous miscarriage than in viable pregnancies. Collectively these observations suggest that over-activation of nuclear factor kappa B has a relationship with early spontaneous miscarriages.
authors.affiliation: Xi'an Medical College, Xi'an, China.
authors.forename: Li-Qin
authors.initials: LQ
authors.lastname: Wang
authors.affiliation: Center of Maternal and Child Health, First Affiliated Hospital of Medical School in Xi'an Jiaotong University, Xi'an, China.
authors.forename: Xue-Wen
authors.initials: XW
authors.lastname: Yu
authors.affiliation: Department of Gynecology & Obstetrics, Fourth Hospital of Xi'an City, Xi'an, China.
authors.forename: Chun-Fang
authors.initials: CF
authors.lastname: Yan
authors.affiliation: Xi'an Medical College, Xi'an, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology* / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D002824:Chorionic Villi / Q000378:metabolism*; D003656:Decidua / Q000378:metabolism*; D004847:Epithelial Cells / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018613:Microscopy, Confocal; D016328:NF-kappa B / Q000378:metabolism*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D017154:Stromal Cells / Q000378:metabolism; D051996:Transcription Factor RelA / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D051996:Transcription Factor RelA
references.citation: Am J Pathol. 1989 Apr;134(4):733-9
references.pmid: 2565087
references.citation: Arch Gynecol Obstet. 2004 Dec;270(4):227-9
references.pmid: 15449074
references.citation: Med Sci Monit. 2002 Aug;8(8):CR607-10
references.pmid: 12165750
references.citation: N Engl J Med. 1997 Apr 10;336(15):1066-71
references.pmid: 9091804
references.citation: Oncogene. 1999 Nov 22;18(49):6853-66
references.pmid: 10602461
references.citation: Semin Immunol. 2001 Aug;13(4):219-27
references.pmid: 11437629
references.citation: Tohoku J Exp Med. 2004 Nov;204(3):195-202
references.pmid: 15502418
references.citation: Am J Reprod Immunol. 2004 Sep;52(3):218-23
references.pmid: 15373762
references.citation: Am J Physiol Regul Integr Comp Physiol. 2007 Apr;292(4):R1465-71
references.pmid: 17194723
references.citation: Mol Cell Biol. 1999 Aug;19(8):5785-99
references.pmid: 10409765
references.citation: Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2322-7
references.pmid: 16452166
references.citation: Eur J Obstet Gynecol Reprod Biol. 2007 May;132(1):58-63
references.pmid: 16859822
references.citation: Rev Reprod. 1999 Sep;4(3):160-7
references.pmid: 10521153
references.citation: Mol Hum Reprod. 2000 Jan;6(1):34-40
references.pmid: 10611258
references.citation: Oncogene. 1999 Nov 22;18(49):6910-24
references.pmid: 10602466
references.citation: J Assist Reprod Genet. 2003 Feb;20(2):73-81
references.pmid: 12688591
references.citation: Reproduction. 2001 Jan;121(1):3-19
references.pmid: 11226025
references.citation: Placenta. 2000 Jul-Aug;21(5-6):525-35
references.pmid: 10940203
references.citation: Mol Hum Reprod. 2001 Feb;7(2):175-83
references.pmid: 11160844
references.citation: Biol Reprod. 2002 Aug;67(2):668-73
references.pmid: 12135912
references.citation: J Reprod Immunol. 2002 Jan;53(1-2):241-56
references.pmid: 11730920
references.citation: Trends Cell Biol. 2001 Sep;11(9):372-7
references.pmid: 11514191
references.citation: Nat Immunol. 2002 Mar;3(3):221-7
references.pmid: 11875461
references.citation: Int J Gynaecol Obstet. 2005 Jan;88(1):44-8
references.pmid: 15617704
references.citation: BMC Dev Biol. 2002 Apr 24;2:5
references.pmid: 11972897
references.citation: Am J Physiol Lung Cell Mol Physiol. 2006 Jun;290(6):L1131-8
references.pmid: 16414978
references.citation: J Clin Endocrinol Metab. 2003 Dec;88(12):5846-50
references.pmid: 14671179
references.citation: J Immunol. 2004 Apr 1;172(7):4583-91
references.pmid: 15034076