title: Marker-free lung tumor trajectory estimation from a cone beam CT sinogram.
abstract: An algorithm was developed to estimate the 3D lung tumor position using the projection data forming a cone beam CT sinogram and a template registration method. A pre-existing respiration-correlated CT image was used to generate templates of the target, which were then registered to the individual cone beam CT projections, and estimates of the target position were made for each projection. The registration search region was constrained based on knowledge of the mean tumor position during the cone beam CT scan acquisition. Several template registration algorithms were compared, including correlation coefficient and robust methods such as block correlation, robust correlation coefficient and robust gradient correlation. Robust registration metrics were found to be less sensitive to occlusions such as overlying tissue and the treatment couch. The mean accuracy of the position estimation was 1.4 mm in phantom with a robust registration algorithm. In two research subjects with peripheral tumors, the mean position and mean target excursion were estimated to within 2.0 mm compared to the results obtained with a '4D' registration of 4D image volumes.
authors.affiliation: Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA, USA. gdhugo@vcu.edu
authors.forename: Geoffrey D
authors.initials: GD
authors.lastname: Hugo
authors.forename: Jian
authors.initials: J
authors.lastname: Liang
authors.forename: Di
authors.initials: D
authors.lastname: Yan
mesh_terms: D054893:Cone-Beam Computed Tomography / Q000379:methods* / Q000592:standards; D006801:Humans; D021621:Imaging, Three-Dimensional; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D012015:Reference Standards
references.citation: Int J Radiat Oncol Biol Phys. 1999 Jul 1;44(4):911-9
references.pmid: 10386650
references.citation: Phys Med Biol. 2008 Aug 21;53(16):N315-27
references.pmid: 18660557
references.citation: Phys Med Biol. 2009 Jan 7;54(1):117-33
references.pmid: 19075358
references.citation: Phys Med Biol. 2008 Aug 21;53(16):4331-53
references.pmid: 18660559
references.citation: Int J Radiat Oncol Biol Phys. 2007 Dec 1;69(5):1634-41
references.pmid: 18029112
references.citation: Phys Med Biol. 2008 Feb 21;53(4):1087-98
references.pmid: 18263960
references.citation: Med Phys. 2005 Apr;32(4):1176-86
references.pmid: 15895601
references.citation: Phys Med Biol. 2005 Oct 7;50(19):4481-90
references.pmid: 16177484
references.citation: Lung Cancer. 2006 Jan;51(1):41-51
references.pmid: 16198022
references.citation: Int J Radiat Oncol Biol Phys. 2000 Jul 1;47(4):1121-35
references.pmid: 10863086
references.citation: Phys Med Biol. 2007 Oct 21;52(20):6229-42
references.pmid: 17921582
references.citation: IEEE Trans Med Imaging. 2004 Nov;23(11):1430-44
references.pmid: 15554130
references.citation: Int J Radiat Oncol Biol Phys. 2008 Nov 15;72(4):1221-7
references.pmid: 18954716
references.citation: Med Phys. 2009 Jul;36(7):3059-71
references.pmid: 19673205
references.citation: Med Phys. 2006 Oct;33(10):3874-900
references.pmid: 17089851
references.citation: Int J Radiat Oncol Biol Phys. 2000 Nov 1;48(4):1187-95
references.pmid: 11072178
references.citation: Med Phys. 2004 Oct;31(10):2738-41
references.pmid: 15543778
references.citation: Int J Radiat Oncol Biol Phys. 2008 Feb 1;70(2):590-8
references.pmid: 18037579
references.citation: Int J Radiat Oncol Biol Phys. 2007 Jul 15;68(4):1036-46
references.pmid: 17379442
references.citation: Int J Radiat Oncol Biol Phys. 2008 Dec 1;72(5):1587-96
references.pmid: 19028282
references.citation: Phys Med Biol. 2006 May 21;51(10):2567-83
references.pmid: 16675870
references.citation: Phys Med Biol. 2005 Jun 21;50(12):2779-98
references.pmid: 15930602
references.citation: Int J Radiat Oncol Biol Phys. 2008 Nov 15;72(4):1250-8
references.pmid: 18823717
references.citation: Med Phys. 2008 May;35(5):1718-33
references.pmid: 18561647
references.citation: IEEE Trans Image Process. 2005 Aug;14(8):1063-73
references.pmid: 16121455
references.citation: Radiother Oncol. 2007 Apr;83(1):57-64
references.pmid: 17306394
references.citation: Med Phys. 2008 May;35(5):1793-806
references.pmid: 18561654
references.citation: Int J Radiat Oncol Biol Phys. 1999 Oct 1;45(3):603-11
references.pmid: 10524412