title: [Long-term results of patients with congenital diaphragmatic hernia].
abstract: OBJECTIVE
  Introduction of advanced therapeutic modalities for diaphragmatic congenital hernia (CDH) has allowed to reach considerable improvements in survival rate. Nevertheless, there are few studies which analyze the clinical evolution of the long-term survivors. The aim of this work is to analyze the outcomes of the patients with CDH in our hospital.
  
  
  METHODS
  Fifty-five neonates with CDH were treated in our center between 1998 and 2005. We included in the study those patients that were alive at the moment of first hospital discharge (72%; n=40 patients). ECMO therapy was needed in 6 of them during neonatal treatment. A descriptive transverse review of the clinical record as well as a telephonic interview to the parents was performed for the respiratory, cardiological, digestive and neurological conditions, following standard diagnostic studies in every case. The mean age of the children in the moment of the study was 4.2 years (1-9).
  
  
  RESULTS
  The 8.3% of the children needed domiciliary oxygen therapy during a maximum of 3 months in all the cases. 22% of the cases suffered from respiratory problems, being bronchiolitis and pneumonia the most frequent diagnoses. Only a patient developed asthma. The gastroesophageal reflux is the most frequent long-term condition (47%), but only 8.3% needs surgical treatment. Regarding to cardiological problems, 14% developed pulmonary hypertension, being slight - moderate in all the cases but in one case who was the only deceased of the series. Regarding to neurological problems only 1 patient developed serious alterations (brain paralysis), having suffered a hemorrhage parenquimatosa during the treatment with ECMO. No other patient presents motor, visual nor auditory alterations in the development, last mild alteration in language (4 patients). Differences do not exist with the group of patients that did not need ECMO during the treatment in cardiological and digestive complications, being higher percentage with respiratory problems.
  
  
  CONCLUSIONS
  In our sample only 2 patients present serious sequels (5%). Of this preliminary study we can conclude that the comorbility in the CDH is very low having these patient a good development and good quality of life.
authors.affiliation: Servicio Neonatología, Hospital Infantil Gregorio Marañón, Madrid.
authors.forename: C
authors.initials: C
authors.lastname: Menéndez
authors.forename: M
authors.initials: M
authors.lastname: Fariñas
authors.forename: A
authors.initials: A
authors.lastname: Parente
authors.forename: A
authors.initials: A
authors.lastname: Laín
authors.forename: M
authors.initials: M
authors.lastname: Fanjul
authors.forename: P
authors.initials: P
authors.lastname: Chimenti
authors.forename: N
authors.initials: N
authors.lastname: Carrera
authors.forename: A
authors.initials: A
authors.lastname: Huerga
authors.forename: C
authors.initials: C
authors.lastname: Corona
authors.forename: I
authors.initials: I
authors.lastname: Marsinyach
authors.forename: A
authors.initials: A
authors.lastname: Cañizo
authors.forename: S
authors.initials: S
authors.lastname: Villar
authors.forename: M
authors.initials: M
authors.lastname: Sánchez-Luna
authors.forename: J
authors.initials: J
authors.lastname: Vázquez
mesh_terms: D003430:Cross-Sectional Studies; D006548:Hernia, Diaphragmatic / Q000601:surgery*; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D013997:Time Factors