N,N-dimethylbiguanide complexes displaying low cytotoxicity as potential large spectrum antimicrobial agents.
The new complexes M(DMBG)(2)(ClO(4))(2) (M:Mn, Ni, Cu and Zn; DMBG: N,N-dimethylbiguanide) have been synthesized and characterized by IR, EPR, (1)H NMR, (13)C NMR as well as electronic spectroscopy data. Complex [Ni(DMBG)(2)](ClO(4))(2).2DMF (DMF: N,N-dimethylformamide) crystallizes in the monoclinic P2(1)/c space group while [Cu(DMBG)(2)](ClO(4))(2) adopt monoclinic P21/c space group as X-ray single crystal data indicate. The redox behavior of complexes was investigated by cyclic voltammetry. The metal-free N,N-dimethylbiguanide and complexes exhibit specific anti-infective properties as demonstrated the low MIC values, a large antimicrobial spectrum and also inhibit the ability of Pseudomonas aeruginosa and Staphylococcus aureus strains to colonize the inert surfaces. The complexes exhibit also a low cytotoxicity levels on HeLa cells.
Olar
Rodica
R
Department of Inorganic Chemistry, University of Bucharest, 90-92 Panduri Street, Bucharest, Romania. rodica_m_olar@yahoo.com
Badea
Mihaela
M
Marinescu
Dana
D
Chifiriuc
Mariana-Carmen
MC
Bleotu
Coralia
C
Grecu
Maria Nicoleta
MN
Iorgulescu
Emilia-Elena
EE
Lazar
Veronica
V
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D001419:Bacteria / Q000187:drug effects; D018360:Crystallography, X-Ray; D004563:Electrochemistry; D005658:Fungi / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D008687:Metformin / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D010084:Oxidation-Reduction; D013057:Spectrum Analysis; D013237:Stereoisomerism
D000890:Anti-Infective Agents; D009942:Organometallic Compounds; D008687:Metformin