title: Genetic loci influencing kidney function and chronic kidney disease.
abstract: Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Imperial College of London, London, UK. john.chambers@ic.ac.uk
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mesh_terms: D001692:Biological Transport; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000378:metabolism; D005060:Europe; D005786:Gene Expression Regulation; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007676:Kidney Failure, Chronic / Q000235:genetics* / Q000473:pathology; D008957:Models, Genetic
chemical_list: D055316:Cystatin C; D005819:Genetic Markers; D003404:Creatinine
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