title: Dengue in infants: an overview.
abstract: Dengue virus (DV) infection causes either a benign syndrome, dengue fever, or a severe syndrome, dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS), that is characterized by systemic capillary leakage, thrombocytopaenia and hypovolaemic shock. DHF/DSS occur mainly due to secondary infection by a heterotype DV infection in children and adults but in infants even primary infection by DV causes DHF/DSS. Clinical manifestations of DHF/DSS are more significantly associated with death in infants compared with older children. Vertical transmission of DV and anti-DV IgG has been well reported and is responsible for the pathogenesis of DV disease and its manifestations in infants. The complex pathogenesis of DHF/DSS during primary dengue in infants, with multiple age-related confounding factors, offers unique challenges to investigators. Dengue in infants is not often studied in detail due to practical limitations, but looking at the magnitude of DHF/DSS in infants and the unique opportunities this model provides, there is a need to focus on this problem. This paper reviews existing knowledge on this aspect of DV infection and the challenges it provides.
authors.affiliation: Department of Microbiology, CSM Medical University, Lucknow, India.
authors.forename: Amita
authors.initials: A
authors.lastname: Jain
authors.forename: Umesh C
authors.initials: UC
authors.lastname: Chaturvedi
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D003715:Dengue / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D003716:Dengue Virus / Q000276:immunology* / Q000472:pathogenicity*; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D007231:Infant, Newborn
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G
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