Synthesis and antitumor activity of new shikonin glycosides.
Eleven shikonin glycosides were synthesized and evaluated for their antitumor activity in vitro. Some of them were found to exhibit cytotoxic activities against both drug sensitive cell lines (K562, MCF-7 and HL60) and their drug resistant cell sublines (K562/ADR, MCF-7/ADR and HL60/ADR).
Su
Yehua
Y
Department of Chemistry, Zhejiang University, 38# Zheda Road, Hangzhou 310027, PR China.
Xie
Jiansheng
J
Wang
Yanguang
Y
Hu
Xun
X
Lin
Xianfu
X
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006027:Glycosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D009285:Naphthoquinones / Q000737:chemistry*
D000970:Antineoplastic Agents; D006027:Glycosides; D009285:Naphthoquinones; C016101:shikonin