Specialization along the left superior temporal sulcus for auditory categorization.
The affinity and temporal course of functional fields in middle and posterior superior temporal cortex for the categorization of complex sounds was examined using functional magnetic resonance imaging (fMRI) and event-related potentials (ERPs) recorded simultaneously. Data were compared before and after subjects were trained to categorize a continuum of unfamiliar nonphonemic auditory patterns with speech-like properties (NP) and a continuum of familiar phonemic patterns (P). fMRI activation for NP increased after training in left posterior superior temporal sulcus (pSTS). The ERP P2 response to NP also increased with training, and its scalp topography was consistent with left posterior superior temporal generators. In contrast, the left middle superior temporal sulcus (mSTS) showed fMRI activation only for P, and this response was not affected by training. The P2 response to P was also independent of training, and its estimated source was more anterior in left superior temporal cortex. Results are consistent with a role for left pSTS in short-term representation of relevant sound features that provide the basis for identifying newly acquired sound categories. Categorization of highly familiar phonemic patterns is mediated by long-term representations in left mSTS. Results provide new insight regarding the function of ventral and dorsal auditory streams.
Liebenthal
Einat
E
Department of Neurology, Medical College of Wisconsin, 8701 Watertown Plank Road, Medical College of Wisconsin, Milwaukee, WI 53226, USA. einatl@mcw.edu
Desai
Rutvik
R
Ellingson
Michael M
MM
Ramachandran
Brinda
B
Desai
Anjali
A
Binder
Jeffrey R
JR
D000161:Acoustic Stimulation; D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D055815:Young Adult
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):11800-6
11050212
J Neurosci. 1993 Jan;13(1):87-103
8423485
Trends Neurosci. 2003 Feb;26(2):100-7
12536133
Neuroimage. 2002 Apr;15(4):733-46
11906217
Psychol Sci. 2009 Jul;20(7):895-903
19515116
Nature. 1996 Aug 15;382(6592):626-8
8757132
Brain. 2001 Jan;124(Pt 1):83-95
11133789
Brain Res Cogn Brain Res. 2003 Oct;17(3):781-91
14561463
Ear Hear. 2001 Apr;22(2):79-90
11324846
J Acoust Soc Am. 2006 Aug;120(2):1075-83
16938993
Trends Cogn Sci. 2000 Apr;4(4):131-138
10740277
Neuroimage. 2004 Feb;21(2):494-506
14980552
Nat Neurosci. 1999 Dec;2(12):1131-6
10570492
Science. 1968 Jul 12;161(3837):186-7
5657070
Neuroimage. 2005 Jul 15;26(4):1019-29
15893476
J Cogn Neurosci. 2004 Nov;16(9):1612-24
15601523
Cereb Cortex. 2009 Dec;19(12):2767-96
19329570
Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):853-60
9448251
Neuroimage. 2004 May;22(1):401-8
15110033
J Neurosci. 2003 Jul 2;23(13):5545-52
12843255
Cereb Cortex. 2000 May;10(5):512-28
10847601
Brain. 2000 Dec;123 Pt 12:2400-6
11099443
J Cogn Neurosci. 2005 Sep;17(9):1353-66
16197689
Nature. 2009 Oct 15;461(7266):983-6
19829380
Neuroimage. 2002 Oct;17(2):859-70
12377160
Cereb Cortex. 2005 Oct;15(10):1621-31
15703256
Cognition. 2004 May-Jun;92(1-2):101-44
15037128
J Neurosci. 2003 Apr 15;23(8):3423-31
12716950
Neuron. 2002 Aug 29;35(5):997-1010
12372292
J Neurosci. 2009 Apr 22;29(16):5234-9
19386919
Neuroimage. 2005 Jan 1;24(1):21-33
15588593
Audiol Neurootol. 2001 Jul-Aug;6(4):178-81
11694723
Audiol Neurootol. 1998 Mar-Jun;3(2-3):86-103
9575379
Clin Neurophysiol. 1999 Dec;110(12):2086-93
10616113
Neuroimage. 2003 May;19(1):113-24
12781731
J Cogn Neurosci. 2008 Jul;20(7):1174-88
18284339
J Cogn Neurosci. 2001 Aug 15;13(6):754-65
11564320
Hum Brain Mapp. 2006 Jul;27(7):562-71
16281283
Psychophysiology. 1991 Mar;28(2):240-4
1946890
Nat Neurosci. 2000 Oct;3(10):966
11017162
Clin Neurophysiol. 2001 Jan;112(1):186-97
11137677
Cereb Cortex. 2005 May;15(5):578-87
15319313
Brain Res Cogn Brain Res. 2005 Oct;25(2):547-53
16198089
Comput Biomed Res. 1996 Jun;29(3):162-73
8812068
Trends Cogn Sci. 2006 Nov;10(11):480-6
16997610
Clin Neurophysiol. 2001 Oct;112(10):1850-9
11595143
Trends Neurosci. 2000 Oct;23(10):475-83
11006464
Neuron. 2005 Nov 23;48(4):687-97
16301183
Trends Cogn Sci. 2009 Jan;13(1):14-9
19070534
Nat Neurosci. 2004 Mar;7(3):295-301
14966525
Curr Opin Neurobiol. 2001 Apr;11(2):157-63
11301234
Cognition. 2004 May-Jun;92(1-2):67-99
15037127
Cereb Cortex. 2009 Jun;19(6):1474-85
18987393
Nat Neurosci. 2000 Oct;3(10):965-6
11017161
J Acoust Soc Am. 2009 Nov;126(5):2159-62
19894795
Neuropsychologia. 1971 Mar;9(1):97-113
5146491
Hum Brain Mapp. 1999;7(2):89-97
9950066
Nat Neurosci. 2002 Sep;5(9):824-6
12196806
Methods Find Exp Clin Pharmacol. 2002;24 Suppl D:5-12
12575463
Cereb Cortex. 2004 Oct;14(10):1088-99
15115745
Cereb Cortex. 2003 Dec;13(12):1362-8
14615301
Nature. 2000 Jan 20;403(6767):309-12
10659849
Neuroreport. 2003 Nov 14;14(16):2105-9
14600506
Nat Rev Neurosci. 2007 May;8(5):393-402
17431404
Neuroimage. 2005 Aug 1;27(1):106-15
15901490
Nat Neurosci. 1999 Dec;2(12):1045-7
10570476
Neuroimage. 2000 Jul;12(1):1-13
10875897
Neuroreport. 2005 Nov 7;16(16):1781-5
16237326
J Cogn Neurosci. 2008 Mar;20(3):541-52
18004944
Cortex. 2006 May;42(4):644-51
16881272
J Acoust Soc Am. 1993 Sep;94(3 Pt 1):1242-55
8408964
Neuroimage. 2006 Apr 1;30(2):563-9
16275021
Neuroreport. 1994 Jun 2;5(10):1189-92
7919162
Neuroimage. 2009 Feb 1;44(3):839-48
18976717