title: Organocatalytic asymmetric intramolecular [3+2] cycloaddition: a straightforward approach to access multiply substituted hexahydrochromeno[4,3-b]pyrrolidine derivatives in high optical purity.
abstract: A chiral phosphoric acid-catalyzed intramolecular 1,3-dipolar cycloaddition of 4-(2-formylphenoxy)butenoates with amino esters provides hexahydromeno[4,3-b]pyrrolidine derivatives in high enantioselectivity (up to 94% ee).
authors.affiliation: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, 610041.
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Song
authors.forename: Xi-Feng
authors.initials: XF
authors.lastname: Tu
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Xiao-Hua
authors.initials: XH
authors.lastname: Chen
authors.forename: Liu-Zhu
authors.initials: LZ
authors.lastname: Gong
mesh_terms: D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010756:Phosphoric Acids / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D010756:Phosphoric Acids; D011759:Pyrrolidines; C030242:phosphoric acid