Cembranoids from the soft corals Sinularia granosa and Sinularia querciformis.
Two new cembranoids, namely granosolides C (1) and D (2), along with one known cembranoid 4, were isolated from the soft coral Sinularia granosa. Chemical investigation of Sinularia querciformis also afforded one new cembranoid, querciformolide E (3), along with four known cembranoids 4-7. The structures of these compounds were elucidated on the basis of their spectroscopic data. Both 4 and 5 were shown to significantly inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase protein in lipopolysaccharide-stimulated RAW264.7 macrophage cells.
Lu
Yi
Y
Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
Su
Jui-Hsin
JH
Huang
Chiung-Yao
CY
Liu
Yung-Chun
YC
Kuo
Yao-Haur
YH
Wen
Zhi-Hong
ZH
Hsu
Chi-Hsin
CH
Sheu
Jyh-Horng
JH
D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D051546:Cyclooxygenase 2 / Q000276:immunology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D015394:Molecular Structure; D019001:Nitric Oxide Synthase / Q000276:immunology
D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D008070:Lipopolysaccharides; D019001:Nitric Oxide Synthase; D051546:Cyclooxygenase 2