title: Broadening Options for Long-term Dialysis in the Elderly (BOLDE): differences in quality of life on peritoneal dialysis compared to haemodialysis for older patients.
abstract: BACKGROUND
  Health-related quality of life (QOL) is an important outcome for older people who are often on dialysis for life. Little is, however, known about differences in QOL on haemodialysis (HD) and peritoneal dialysis (PD) in older age groups. Randomising patients to either modality to assess outcomes is not feasible.
  
  
  METHODS
  In this cross-sectional, multi-centred study we conducted QOL assessments (Short Form-12 Mental and Physical Component Summary scales, Hospital Anxiety and Depression Scale and Illness Intrusiveness Ratings Scale) in 140 people (aged 65 years or older) on PD and HD.
  
  
  RESULTS
  The groups were similar in age, gender, time on dialysis, ethnicity, Index of Deprivation (based on postcode), dialysis adequacy, cognitive function (Mini-Mental State Exam and Trail-Making Test B), nutritional status (Subjective Global Assessment) and social networks. There was a higher comorbidity score in the HD group. Regression analyses were undertaken to ascertain which variables significantly influence each QOL assessment. All were influenced by symptom count highlighting that the patient's perception of their symptoms is a critical determinant of their mental and physical well being. Modality was found to be an independent predictor of illness intrusion with greater intrusion felt in those on HD.
  
  
  CONCLUSIONS
  Overall, in two closely matched demographic groups of older dialysis patients, QOL was similar, if not better, in those on PD. This study strongly supports offering PD to all suitable older people.
authors.affiliation: Imperial College Kidney and Transplant Institute, Hammersmith Hospital, London, UK. e.a.brown@imperial.ac.uk
authors.forename: Edwina A
authors.initials: EA
authors.lastname: Brown
authors.forename: Lina
authors.initials: L
authors.lastname: Johansson
authors.forename: Ken
authors.initials: K
authors.lastname: Farrington
authors.forename: Hugh
authors.initials: H
authors.lastname: Gallagher
authors.forename: Tom
authors.initials: T
authors.lastname: Sensky
authors.forename: Fabiana
authors.initials: F
authors.lastname: Gordon
authors.forename: Maria
authors.initials: M
authors.lastname: Da Silva-Gane
authors.forename: Nigel
authors.initials: N
authors.lastname: Beckett
authors.forename: Mary
authors.initials: M
authors.lastname: Hickson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D003863:Depression / Q000453:epidemiology; D005260:Female; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D010530:Peritoneal Dialysis / Q000523:psychology*; D011788:Quality of Life; D006435:Renal Dialysis / Q000523:psychology*
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