The effect of ultrasound on lipase-catalyzed regioselective acylation of mangiferin in non-aqueous solvents.
A simple and efficient method for regioselective acylation of mangiferin catalyzed by lipase under ultrasound irradiation is reported. Compared with the conventional methods, its main advantages are shorter reaction time and higher yields. The optimum conditions were screened out. Under the optimal conditions (lipase: PCL, acyl donor: vinyl acetate; reaction solvent: DMSO, reaction temperature: 45 degrees C, ultrasonic power: 200 W; substrate ratio: acyl donor/mangiferin 6/1, enzyme loading: 6 mg/ml), the regioselective acylation yield was up to 84%.
Wang
Zhi
Z
Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun, China.
Wang
Ren
R
Tian
Jin
J
Zhao
Bo
B
Wei
Xiao-Fei
XF
Su
Ya-Lun
YL
Li
Chun-Yuan
CY
Cao
Shu-Gui
SG
Ji
Teng-Fei
TF
Wang
Lei
L
D000215:Acylation; D002384:Catalysis; D008049:Lipase / Q000378:metabolism* / Q000528:radiation effects*; D012997:Solvents; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000737:chemistry; D014867:Water; D044004:Xanthones / Q000737:chemistry*
D012997:Solvents; D014753:Vinyl Compounds; D044004:Xanthones; D014867:Water; C013592:mangiferin; D008049:Lipase