title: The role of serotonin and possible interaction of serotonin-related genes with alcohol dehydrogenase and aldehyde dehydrogenase genes in alcohol dependence-a review.
abstract: Alcohol dependence is believed to be a multifactorial, polygenic disorder involving complex gene-gene and gene-environment interactions and confounded by heterogeneity and sociocultural factors. Serotonin (5-Hydroxytryptamine, 5-HT) is thought to be involved in many aspects of alcohol consumption, abuse, and dependence. There was some evidence that serotonin-related genes might interact with the alcohol dehydrogenase (ADH) and the aldehyde dehydrogenase (ALDH) genes in the development of alcohol dependence. In the current review, we discuss the role of serotonin and possible interaction of serotonin-related genes with ADH and ALDH genes in alcohol dependence.
authors.forename: Charles Lung-Cheng
authors.initials: CL
authors.lastname: Huang
references.citation: Prog Nucleic Acid Res Mol Biol. 1991;40:255-87
references.pmid: 2031085
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2008 Jun 5;147B(4):447-53
references.pmid: 17948892
references.citation: Psychiatr Genet. 2001 Jun;11(2):89-94
references.pmid: 11525423
references.citation: Alcohol Clin Exp Res. 2003 May;27(5):868-79
references.pmid: 12766633
references.citation: Q J Stud Alcohol. 1974 Mar;35(1):1-14
references.pmid: 4151232
references.citation: Am J Psychiatry. 2000 Dec;157(12):2045-7
references.pmid: 11097976
references.citation: Alcohol Alcohol. 2001 Mar-Apr;36(2):99-103
references.pmid: 11259204
references.citation: Alcohol Clin Exp Res. 2002 Sep;26(9):1330-5
references.pmid: 12351926
references.citation: Arch Gen Psychiatry. 1992 Aug;49(8):599-608
references.pmid: 1637250
references.citation: Alcohol Clin Exp Res. 1998 Aug;22(5):1080-5
references.pmid: 9726278
references.citation: Life Sci. 1991;49(25):1929-34
references.pmid: 1745108
references.citation: Science. 1987 Apr 24;236(4800):410-6
references.pmid: 2882604
references.citation: Arch Gen Psychiatry. 1980 May;37(5):561-3
references.pmid: 7377912
references.citation: Structure. 1997 May 15;5(5):701-11
references.pmid: 9195888
references.citation: Science. 1996 Nov 29;274(5292):1527-31
references.pmid: 8929413
references.citation: Br J Pharmacol. 1968 Sep;34(1):38-42
references.pmid: 4386372
references.citation: Semin Liver Dis. 1993 May;13(2):126-35
references.pmid: 8337601
references.citation: Biochemistry. 1984 Nov 20;23(24):5847-53
references.pmid: 6395883
references.citation: Alcohol Clin Exp Res. 2001 May;25(5):637-43
references.pmid: 11371711
references.citation: Clin Chim Acta. 1997 Jan 17;257(2):199-250
references.pmid: 9118563
references.citation: Am J Med Genet. 1993 Jul 15;48(2):71-3
references.pmid: 8362928
references.citation: Psychol Med. 1994 Feb;24(1):69-80
references.pmid: 8208896
references.citation: Nat Genet. 1996 Dec;14(4):371-3
references.pmid: 8944011
references.citation: J Lab Clin Med. 1993 Sep;122(3):234-40
references.pmid: 8409698
references.citation: Am J Pharmacogenomics. 2003;3(4):217-32
references.pmid: 12930156
references.citation: Ann Intern Med. 1997 Sep 1;127(5):376-9
references.pmid: 9273829
references.citation: J Formos Med Assoc. 2002 Nov;101(11):769-74
references.pmid: 12517056
references.citation: Pharmacology. 2000 Sep;61(3):192-8
references.pmid: 10971205
references.citation: Biol Psychiatry. 1999 Mar 1;45(5):647-51
references.pmid: 10088053
references.citation: Arch Gen Psychiatry. 1981 Aug;38(8):861-8
references.pmid: 7259422
references.citation: Alcohol Clin Exp Res. 2004 Mar;28(3):374-84
references.pmid: 15084894
references.citation: Am J Med Genet. 1999 Feb 5;88(1):61-6
references.pmid: 10050969
references.citation: Pharmacogenetics. 1999 Aug;9(4):463-76
references.pmid: 10780266
references.citation: Alcohol Clin Exp Res. 2005 Jul;29(7):1341-50
references.pmid: 16088998
references.citation: Alcohol Clin Exp Res. 1997 Nov;21(8):1356-9
references.pmid: 9394104
references.citation: Alcohol Clin Exp Res. 1996 Apr;20(2):391-402
references.pmid: 8730235
references.citation: Life Sci. 1997;61(5):577-83
references.pmid: 9247327
references.citation: Am J Hum Genet. 1999 Sep;65(3):599-605
references.pmid: 10441565
references.citation: J Korean Med Sci. 2001 Dec;16(6):745-50
references.pmid: 11748356
references.citation: Adv Hum Genet. 1986;15:249-90
references.pmid: 3006456
references.citation: Am J Med Genet. 2001 Aug 8;105(6):489-97
references.pmid: 11496363
references.citation: Compr Psychiatry. 1998 Jul-Aug;39(4):176-84
references.pmid: 9675501
references.citation: Clin Neurosci. 1995;3(3):174-81
references.pmid: 8612062
references.citation: Am J Hum Genet. 1991 Apr;48(4):677-81
references.pmid: 2014795
references.citation: Trends Pharmacol Sci. 1992 Feb;13(2):69-75
references.pmid: 1561716
references.citation: Alcohol. 1999 Feb;17(2):107-12
references.pmid: 10064377
references.citation: Br J Psychiatry. 1996 Jun;168(6):762-7
references.pmid: 8773821
references.citation: Biochemistry. 1983 Apr 12;22(8):1852-7
references.pmid: 6342668
references.citation: Alcohol Clin Exp Res. 1997 Oct;21(7):1272-7
references.pmid: 9347089
references.citation: Alcohol Clin Exp Res. 2001 Jul;25(7):953-9
references.pmid: 11505018
references.citation: Am J Med Genet. 2001 Jul 8;105(5):446-50
references.pmid: 11449397
references.citation: Am J Hum Genet. 1999 Apr;64(4):1147-57
references.pmid: 10090900
references.citation: Am J Hum Genet. 1999 Sep;65(3):795-807
references.pmid: 10441588
references.citation: Hum Genet. 1995 Jun;95(6):677-80
references.pmid: 7789954
references.citation: Recent Dev Alcohol. 1993;11:231-48
references.pmid: 8234925
references.citation: Alcohol Clin Exp Res. 1999 Jul;23(7):1281-4
references.pmid: 10443997
references.citation: J Lab Clin Med. 1967 Jan;69(1):132-40
references.pmid: 4289445
references.citation: Acta Psychiatr Scand. 2001 Aug;104(2):96-103
references.pmid: 11473502
references.citation: Alcohol Clin Exp Res. 1996 Feb;20(1):52-5
references.pmid: 8651462
references.citation: Biochem Pharmacol. 1999 Aug 1;58(3):389-95
references.pmid: 10424757
references.citation: Psychiatr Genet. 2002 Sep;12(3):143-53
references.pmid: 12218658
references.citation: J Clin Invest. 1989 Jan;83(1):314-6
references.pmid: 2562960
references.citation: Biol Psychiatry. 1994 Sep 15;36(6):395-421
references.pmid: 7803601
references.citation: Arch Gen Psychiatry. 1991 Jan;48(1):19-28
references.pmid: 1984758
references.citation: Am J Psychiatry. 1995 Aug;152(8):1219-21
references.pmid: 7625477
references.citation: Brain Res Bull. 2002 Jan 1;57(1):103-7
references.pmid: 11827742
references.citation: Science. 1994 Jun 17;264(5166):1715-23
references.pmid: 8209252
references.citation: Alcohol Clin Exp Res. 1997 Jun;21(4):596-601
references.pmid: 9194910
references.citation: Psychol Med. 1990 Feb;20(1):11-22
references.pmid: 2181516
references.citation: Alcohol Alcohol. 1995 Mar;30(2):153-61
references.pmid: 7662033
references.citation: Eur Arch Psychiatry Neurol Sci. 1986;235(4):197-9
references.pmid: 3486125
references.citation: Pharmacogenetics. 1992 Apr;2(2):48-62
references.pmid: 1302043
references.citation: Alcohol Alcohol Suppl. 1994;2:113-9
references.pmid: 8974324
references.citation: Eur J Biochem. 1999 Jun;262(2):324-9
references.pmid: 10336614
references.citation: Naunyn Schmiedebergs Arch Pharmacol. 1982 Dec;321(4):293-7
references.pmid: 7167204
references.citation: Life Sci. 1993;53(10):847-55
references.pmid: 7689134
references.citation: Eur J Biochem. 1987 Sep 1;167(2):185-93
references.pmid: 3622513
references.citation: Biochem Biophys Res Commun. 1986 Sep 30;139(3):1009-16
references.pmid: 2429655
references.citation: Alcohol Alcohol. 1994 Nov;29(6):707-10
references.pmid: 7695788
references.citation: Mol Psychiatry. 1999 Jul;4(4):385-8
references.pmid: 10483057