[The association between vitamin D and bone mineral density of urban postmenopausal women in Beijing].
OBJECTIVE
To study the association between vitamin D status and bone mineral density(BMD) in urban postmenopausal women in Beijing.


METHODS
A total of 400 community-dwelling women older than 60 (median age 67.8 years) were selected randomly from 17 community of 3 districts in Beijing by cluster sampling method from May to July, 2008. Serum 25(OH)D concentrations were measured by radioimmunoassay, using the DiaSorin kit, America. The objects were assigned into four groups: vitamin D deficient group (group A, 25(OH)D < 25 nmol/L), insufficient group(group B, 25 nmol/L < 25(OH)D < or = 50 nmol/L), normal group (group C, 50 nmol/L < 25(OH)D < or = 75 nmol/L) and enough group (group D, 25(OH)D > 75 nmol/L). The BMD at total, lumbar spine (L(2-4)) and proximal femur were measured by dual-energy X-ray absorptiometry (DEXA).


RESULTS
The mean concentration of serum 25(OH)D concentration was (36.0 +/- 14.6) nmol/L, BMD at total and proximal femur were respectively (0.829 +/- 0.090) and (0.679 +/- 0.106) g/cm(2). The mean BMD at total of group A, B, C + D were respectively (0.811 +/- 0.077), (0.825 +/- 0.088) and (0.864 +/- 0.112) g/cm(2)(F = 16.93, P < 0.01), and BMD at proximal femur of group A, B, C + D were respectively (0.666 +/- 0.107), (0.673 +/- 0.099) and (0.725 +/- 0.117) g/cm(2)(F = 18.36, P < 0.01). The 25(OH)D level was positively correlated with BMD at total body and proximal femur (r values were 0.17 and 0.18, both P values < 0.05).


CONCLUSIONS
Vitamin D status was highly correlated with BMD at lumbar spine (L(2-4)), proximal femur, pelvis and limbs for the postmenopausal older women.
Liu
Ying
Y
Department of Women and Children's Health of Public Health Institute of Shan Dong University, Jinan 250012, China.
Hu
Xiao-Qi
XQ
Fu
Ping
P
Wang
Cui-Xia
CX
Duan
Yi-Fan
YF
Li
Jun
J
Zhang
Qian
Q
D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D002681:China; D005260:Female; D005269:Femur / Q000378:metabolism; D006801:Humans; D008159:Lumbar Vertebrae / Q000378:metabolism; D008875:Middle Aged; D017698:Postmenopause; D014807:Vitamin D / Q000097:blood*
D014807:Vitamin D