title: Prognosis of cancer with branch duct type IPMN of the pancreas.
abstract: OBJECTIVE
  To examine the coexistence of metachronous and synchronous cancer in branch duct intraductal papillary mucinous neoplasms of the pancreas (IPMN).
  
  
  METHODS
  We reviewed the records of 145 patients with branch duct IPMN between January 1991 and April 2008 and assessed the relationship between IPMN and intra- or extra-pancreatic carcinoma and the outcome of IPMN.
  
  
  RESULTS
  The mean observation period was 55.9 +/- 45.3 mo. Among the 145 patients, the frequency of extra-pancreatic cancer was 29.0%. The frequency of gastric cancer, colon cancer, breast cancer, and pancreatic cancer were 25.5%, 15.7%, 13.7%, and 9.8%, respectively. Twenty (13.8%) of the patients died. The cause of death was extra-pancreatic carcinoma in 40%, pancreatic cancer in 25%, IPMN per se in 20%, and benign disease in 15% of the patients.
  
  
  CONCLUSIONS
  The prognosis for IPMN depends not on the IPMN per se, but on the presence of intra- or extra-pancreatic cancer.
authors.affiliation: Department of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjyuku, Shinjyuku-ku, Tokyo 160-0023, Japan.
authors.forename: Nobuhito
authors.initials: N
authors.lastname: Ikeuchi
authors.forename: Takao
authors.initials: T
authors.lastname: Itoi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sofuni
authors.forename: Fumihide
authors.initials: F
authors.lastname: Itokawa
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: Toshio
authors.initials: T
authors.lastname: Kurihara
authors.forename: Kentaro
authors.initials: K
authors.lastname: Ishii
authors.forename: Shujiro
authors.initials: S
authors.lastname: Tsuji
authors.forename: Junko
authors.initials: J
authors.lastname: Umeda
authors.forename: Fuminori
authors.initials: F
authors.lastname: Moriyasu
authors.forename: Akihiko
authors.initials: A
authors.lastname: Tsuchida
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kasuya
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008495:Medical Oncology / Q000379:methods; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D016896:Treatment Outcome
references.citation: Surgery. 2006 Jun;139(6):749-54
references.pmid: 16782429
references.citation: Clin Gastroenterol Hepatol. 2006 Oct;4(10):1265-70
references.pmid: 16979953
references.citation: Ann Surg Oncol. 2008 Nov;15(11):3193-8
references.pmid: 18784959
references.citation: Arch Surg. 2006 Jan;141(1):51-6; discussion 56
references.pmid: 16415411
references.citation: Gut. 2008 Nov;57(11):1561-5
references.pmid: 18477671
references.citation: Pancreatology. 2008;8(6):577-82
references.pmid: 18824881
references.citation: Jpn J Clin Oncol. 2002 Apr;32(4):146-51
references.pmid: 12072425
references.citation: Ann Surg. 2004 May;239(5):678-85; discussion 685-7
references.pmid: 15082972
references.citation: World J Gastroenterol. 2005 Sep 28;11(36):5688-90
references.pmid: 16237766
references.citation: J Gastrointest Surg. 2003 Jan;7(1):12-19
references.pmid: 12559180
references.citation: Gastroenterology. 2002 Nov;123(5):1500-7
references.pmid: 12404225
references.citation: Clin Gastroenterol Hepatol. 2008 Jul;6(7):807-14
references.pmid: 18304885
references.citation: Pancreatology. 2002;2(5):484-90
references.pmid: 12378117
references.citation: Hepatogastroenterology. 2000 Jul-Aug;47(34):1129-34
references.pmid: 11020896
references.citation: Am J Gastroenterol. 1999 Feb;94(2):470-3
references.pmid: 10022648
references.citation: World J Surg. 2005 Dec;29(12):1650-7
references.pmid: 16311856
references.citation: Cancer. 2002 Jan 1;94(1):62-77
references.pmid: 11815961