Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of Schizophrenia.
Inhibition of the P50 evoked electroencephalographic response to the second of paired auditory stimuli has been frequently examined as a neurophysiological deficit in schizophrenia. The Consortium on the Genetics of Schizophrenia (COGS), a 7-site study funded by the National Institute of Mental Health, examined this endophenotype in recordings from 181 probands with schizophrenia, 429 of their first degree relatives, and 333 community comparison control subjects. Most probands were treated with second generation antipsychotic medications. Highly significant differences in P50 inhibition, measured as either the ratio of amplitudes or their difference in response to the two stimuli, were found between the probands and the community comparison sample. There were no differences between the COGS sites for these findings. For the ratio parameter, an admixture analysis found that nearly 40% of the relatives demonstrated deficiencies in P50 inhibition that are comparable to the deficit found in the probands. These results indicate that P50 auditory evoked potentials can be recorded across multiple sites and reliably demonstrate a physiological abnormality in schizophrenia. The appearance of the physiological abnormality in a substantial proportion of clinically unaffected first degree relatives is consistent with the hypothesis that deficits in cerebral inhibition are a familial neurobiological risk factor for the illness.
Olincy
Ann
A
Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA. Ann.olincy@ucdenver.edu
Braff
David L
DL
Adler
Lawrence E
LE
Cadenhead
Kristin S
KS
Calkins
Monica E
ME
Dobie
Dorcas J
DJ
Green
Michael F
MF
Greenwood
Tiffany A
TA
Gur
Raquel E
RE
Gur
Reuben C
RC
Light
Gregory A
GA
Mintz
James
J
Nuechterlein
Keith H
KH
Radant
Allen D
AD
Schork
Nicholas J
NJ
Seidman
Larry J
LJ
Siever
Larry J
LJ
Silverman
Jeremy M
JM
Stone
William S
WS
Swerdlow
Neal R
NR
Tsuang
Debby W
DW
Tsuang
Ming T
MT
Turetsky
Bruce I
BI
Wagner
Brandie D
BD
Freedman
Robert
R
D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000235:genetics* / Q000502:physiology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009433:Neural Inhibition / Q000235:genetics* / Q000502:physiology*; D010641:Phenotype; D012016:Reference Values; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics* / Q000503:physiopathology*
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