Dengue in infants: an overview.
Dengue virus (DV) infection causes either a benign syndrome, dengue fever, or a severe syndrome, dengue haemorrhagic fever/dengue shock syndrome (DHF/DSS), that is characterized by systemic capillary leakage, thrombocytopaenia and hypovolaemic shock. DHF/DSS occur mainly due to secondary infection by a heterotype DV infection in children and adults but in infants even primary infection by DV causes DHF/DSS. Clinical manifestations of DHF/DSS are more significantly associated with death in infants compared with older children. Vertical transmission of DV and anti-DV IgG has been well reported and is responsible for the pathogenesis of DV disease and its manifestations in infants. The complex pathogenesis of DHF/DSS during primary dengue in infants, with multiple age-related confounding factors, offers unique challenges to investigators. Dengue in infants is not often studied in detail due to practical limitations, but looking at the magnitude of DHF/DSS in infants and the unique opportunities this model provides, there is a need to focus on this problem. This paper reviews existing knowledge on this aspect of DV infection and the challenges it provides.
Jain
Amita
A
Department of Microbiology, CSM Medical University, Lucknow, India.
Chaturvedi
Umesh C
UC
D000914:Antibodies, Viral / Q000097:blood; D003715:Dengue / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D003716:Dengue Virus / Q000276:immunology* / Q000472:pathogenicity*; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D007231:Infant, Newborn
D000914:Antibodies, Viral; D007074:Immunoglobulin G
FEMS Immunol Med Microbiol. 2007 Aug;50(3):285-99
17573929
Clin Infect Dis. 2006 Oct 15;43(8):1023-30
16983615
Southeast Asian J Trop Med Public Health. 2005 Jul;36(4):896-900
16295542
J Immunol. 2002 Jan 1;168(1):356-64
11751981
Clin Infect Dis. 1999 Mar;28(3):637-40
10194092
FEMS Immunol Med Microbiol. 2008 Aug;53(3):287-99
18522648
Trans R Soc Trop Med Hyg. 2001 May-Jun;95(3):307-8
11491005
Immunology. 1979 Dec;38(4):653-8
160396
J Infect Dis. 2009 Dec 15;200(12):1893-900
19911991
J Med Assoc Thai. 2003 Aug;86 Suppl 3:S673-80
14700166
J Infect. 2005 Nov;51(4):287-93
16291281
J Immunol. 2001 Feb 1;166(3):2141-6
11160266
Rev Inst Med Trop Sao Paulo. 1995 Nov-Dec;37(6):517-21
8731265
Bull World Health Organ. 2005 Apr;83(4):308-14
15868023
J Immunol. 2006 Sep 1;177(5):3185-92
16920957
Emerg Infect Dis. 2002 Jul;8(7):738-40
12095447
Bull Soc Pathol Exot. 1991;84(5 Pt 5):513-21
1819401
Am J Trop Med Hyg. 2010 Jan;82(1):128-35
20065008
J Infect Dis. 2001 Jul 1;184(1):80-8
11398113
Am J Trop Med Hyg. 1969 Nov;18(6):997-1021
4390977
Am J Trop Med Hyg. 2005 Dec;73(6):1063-70
16354813
Am J Trop Med Hyg. 1988 Mar;38(2):411-9
3354774
Gaoxiong Yi Xue Ke Xue Za Zhi. 1989 Jan;5(1):31-4
2733065
Ann N Y Acad Sci. 2009 Sep;1171 Suppl 1:E36-41
19751400
Clin Infect Dis. 1994 Feb;18(2):248-9
8161636
PLoS Pathog. 2010 Jan;6(1):e1000718
20062797
Indian J Pediatr. 2010 Apr;77(4):435-7
20140763
J Infect Dis. 2004 Mar 15;189(6):990-1000
14999601
Biomedica. 2003 Dec;23(4):416-23
14968920
Rev Cubana Med Trop. 1994;46(2):76-8
9768239
J Infect Dis. 2000 Jan;181(1):2-9
10608744
J Gen Virol. 1977 Sep;36(3):449-58
562388
Am J Trop Med Hyg. 1999 Sep;61(3):412-9
10497982
Ann Trop Paediatr. 2003 Sep;23(3):159-65
14567830
J Leukoc Biol. 2009 Jan;85(1):71-80
18809735
J Infect Dis. 2007 Apr 15;195(8):1097-107
17357045
Clin Exp Immunol. 2005 Dec;142(3):446-53
16297156
J Virol. 2008 Jan;82(2):927-37
18003724
J Clin Microbiol. 2003 Aug;41(8):3919-21
12904418
PLoS Med. 2009 Oct;6(10):e1000171
19859541
Blood. 2003 Aug 15;102(4):1428-34
12714521
Am J Trop Med Hyg. 2003 Aug;69(2):123-8
13677366
Immunology. 2000 Dec;101(4):570-80
11122462
Indian Pediatr. 1998 Aug;35(8):727-32
10216566
Clin Infect Dis. 1997 Dec;25(6):1374-7
9431381
J Gen Virol. 1978 May;39(2):293-302
206655
J Infect Dis. 2007 Aug 1;196(3):416-24
17597456
J Infect Dis. 2005 Aug 1;192(3):510-9
15995967
Cell Host Microbe. 2008 Sep 11;4(3):229-38
18779049
FEMS Immunol Med Microbiol. 2000 Jul;28(3):183-8
10865168
J Infect Dis. 1975 May;131 Suppl:S62-8
805190
Virology. 1999 Apr 25;257(1):1-6
10208914
Adv Virus Res. 2003;60:421-67
14689700
J Immunol. 2006 May 15;176(10):5741-8
16670279
J Immunol. 1998 May 15;160(10):4730-7
9590218
Am J Trop Med Hyg. 2010 Feb;82(2):330-6
20134013
Am J Trop Med Hyg. 2001 Jul;65(1):70-5
11504411
Rev Med Virol. 2001 Sep-Oct;11(5):301-11
11590668
Ann N Y Acad Sci. 2009 Sep;1171 Suppl 1:E48-56
19751402
Rev Cubana Med Trop. 1993;45(2):97-101
7984823
J Virol. 2004 Dec;78(23):12910-8
15542643
J Clin Invest. 2003 Jun;111(11):1747-55
12782677
Proc Natl Acad Sci U S A. 2007 May 29;104(22):9422-7
17517625
Science. 2008 Dec 5;322(5907):1562-5
19056990
Vaccine. 1998 Aug-Sep;16(14-15):1378-82
9711775
Nat Med. 2003 Jul;9(7):921-7
12808447
Pediatr Infect Dis J. 2008 Jun;27(6):500-4
18434933
FEMS Immunol Med Microbiol. 2009 Jun;56(1):9-24
19239490
Infect Immun. 1979 Apr;24(1):47-50
572345
Emerg Infect Dis. 2002 Dec;8(12):1474-9
12498666
Eur J Immunol. 2005 Feb;35(2):383-90
15682453
J Small Anim Pract. 1978 Nov;19(11):623-30
213654
Blood. 1963 Jun;21:665-73
14027196
Yale J Biol Med. 1970 Apr;42(5):311-28
5419206
Cell Host Microbe. 2007 Dec 13;2(6):417-26
18078693
J Infect Dis. 2008 Aug 15;198(4):516-24
18598189
Indian J Med Res. 2005 May;121(5):639-52
15937367
J Exp Med. 2007 May 14;204(5):979-85
17452519
Southeast Asian J Trop Med Public Health. 2001 Sep;32(3):481-7
11944703
J Exp Med. 2007 Oct 29;204(11):2679-92
17954571
J Infect Dis. 2008 May 15;197(10):1459-67
18444802
J Gen Virol. 2007 Feb;88(Pt 2):365-375
17251552
Med J Malaysia. 2008 Aug;63(3):265-6
19248708