When to screen children with Down syndrome for celiac disease?
The coexistence of Down syndrome (DS) and celiac disease (CD) has been reported in many studies. In our study, we examined 82 children with DS aged 8 months to 8.6 years for the existence of CD using serological markers immunoglobulin A (IgA) and immunoglobulin G (IgG) transglutaminase antibodies, followed by follow-up determination of total IgA levels. In four children who were positive for one of the above-mentioned antibodies, enteric biopsy has been performed that showed absence of CD. Our findings raise doubt about the need for obligatory serological screening of children with DS aged <8 years.
Pavlovic
Momcilo
M
Department of Pediatrics, General Hospital Subotica, Izvorska 3, 24000 Subotica, Serbia. momodec@tippnet.rs
Radlovic
Nedeljko
N
Lekovic
Zoran
Z
Stojsic
Zorica
Z
Puleva
Katja
K
Berenji
Karolina
K
D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002446:Celiac Disease / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008297:Male; D015995:Prevalence; D055771:Serbia / Q000453:epidemiology; D011503:Transglutaminases / Q000097:blood*
D001323:Autoantibodies; D015415:Biomarkers; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D011503:Transglutaminases