title: Methamphetamine enhances paced mating behaviors and neuroplasticity in the medial amygdala of female rats.
abstract: Methamphetamine (METH) is a psychomotor stimulant strongly associated with increases in sexual drive and behavior in women and men. Even though men and women are equally as likely to be addicted to or use METH, studies of sexual behavior often focus on male users. The paucity in studies examining the effect of METH in women is of great concern, when one considers the high correlation with sexually transmitted diseases such as HIV/AIDS and unplanned pregnancies. In fact, why METH so profoundly increases sexual drive is unknown. We have demonstrated that repeated exposure to METH enhances both receptivity and proceptivity in hormonally primed female rats. The current study examined whether a repeated exposure to METH enhanced female-initiated sexual behaviors in hormonally primed rats. In a paced mating paradigm, METH treatment significantly decreased the female's return latency following a mount (57%) and an ejaculation (44%), and the likelihood to leave the male following an intromission (37%) compared to controls. The METH-induced changes in paced mating behavior were accompanied by a 60% increase in spinophilin levels in the medial amygdala following hormonal priming and METH treatment. Taken together, these findings suggest that METH increases female sexual motivation and behavior in the rat potentially via changes in the neural substrate that require repeated exposure to the drug.
authors.affiliation: Program in Neuroscience, University of Maryland, Baltimore, School of Medicine Baltimore, MD 21201, USA. mhold001@umaryland.edu
authors.forename: Mary K
authors.initials: MK
authors.lastname: Holder
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Mong
mesh_terms: D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D005260:Female; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D008840:Microfilament Proteins / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000032:analysis; D009473:Neuronal Plasticity / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D000099273:Neurabins
chemical_list: D000697:Central Nervous System Stimulants; D008694:Methamphetamine; D008840:Microfilament Proteins; D009419:Nerve Tissue Proteins; D000099273:Neurabins
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