Acute homeostatic responses to increased fat consumption in MCH1R knockout mice.
Melanin-concentrating hormone (MCH) is a hypothalamic neuropeptide which has been shown to regulate energy homeostasis. Using genetic knockout mice lacking the MCH1 receptor (MCH1R), we investigated how these mice adapt to metabolic changes caused by excessive caloric consumption. We show that the MCH system is one of the players mediating behavioral and metabolic responses upon increased caloric consumption. MCH1R knockout mice showed decreased tendency of food intake upon exposure to a high-fat diet. They also are resistant to gain weight upon high-fat diet by increasing fat metabolism. Therefore, the MCH system is important in regulating metabolic responses upon various environmental stimuli such as high-fat diet.
Chung
Shinjae
S
Department of Pharmacology, University of California, 369 Med Surge II, Irvine, CA 92612, USA.
Wong
Timothy
T
Nagasaki
Hiroshi
H
Civelli
Olivier
O
D000818:Animals; D004041:Dietary Fats / Q000378:metabolism*; D004435:Eating; D004734:Energy Metabolism; D006706:Homeostasis; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010101:Oxygen Consumption; D017481:Receptors, Somatostatin / Q000235:genetics / Q000378:metabolism*
D004041:Dietary Fats; C491209:Mchr1 protein, mouse; D017481:Receptors, Somatostatin
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