title: SYK kinase signaling and the NLRP3 inflammasome in antifungal immunity.
abstract: Host protection against fungi depends on intact innate and adaptive immune responses. Consistently, fungal infections can cause systemic life-threatening diseases in immunocomprimised individuals, suffering e.g. from cancer or AIDS. Recent work has uncovered essential roles for the spleen tyrosine kinase (SYK) and the cytosolic NLRP3 inflammasome for Interleukin-1beta (IL-1beta) production in innate antifungal immunity. Upon fungal infection, SYK is activated by several C-type lectin pattern recognition receptors on myeloid cells. Subsequently, SYK signals for the production of reactive oxygen species and for gene transcription to induce pro-inflammatory factors, including pro-IL-1beta to initiate antifungal responses. Mature IL-1beta production additionally requires cleavage of the pro-IL-1beta precursor protein by the inflammatory caspase-1 which is controlled within the NLRP3 inflammasome. Here, we discuss how SYK signaling cooperates with the NLRP3 inflammasome for IL-1beta production in antifungal immunity.
authors.affiliation: III. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 81675, Munich, Germany.
authors.forename: Hendrik
authors.initials: H
authors.lastname: Poeck
authors.forename: Jürgen
authors.initials: J
authors.lastname: Ruland
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D053583:Interleukin-1beta / Q000276:immunology*; D047908:Intracellular Signaling Peptides and Proteins / Q000276:immunology*; D009181:Mycoses / Q000276:immunology*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D011505:Protein-Tyrosine Kinases / Q000276:immunology*; D000072377:Syk Kinase
chemical_list: D002352:Carrier Proteins; D053583:Interleukin-1beta; D047908:Intracellular Signaling Peptides and Proteins; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase
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