Lung transplantation in patients with cystic fibrosis and Mycobacterium abscessus infection.
Mycobacterium abscessus lung disease is difficult to treat and has been considered a strong relative contraindication to lung transplantation. We performed double lung transplantation in three cystic fibrosis patients with ongoing, and a fourth with recent treatment for Mycobacterium abscessus lung infection. Despite prolonged antibiotic courses and adjustment of immunosuppressive therapy the first three patients developed skin infection and abscesses. At follow-up after 1, 3, 5 and 7years respectively no patient had evidence of M abscessus infection and all had stable lung function. Lung transplantation in patients with M abscessus lung infection is feasible but may involve severe complications.
Gilljam
Marita
M
Department of Respiratory Medicine and Allergology, Bruna Stråket 11b, Sahlgrenska University Hospital, SE 413 45 Gothenburg, Sweden. marita.gilljam@lungall.gu.se
Scherstén
Henrik
H
Silverborn
Martin
M
Jönsson
Bodil
B
Ericsson Hollsing
Annika
A
D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D003550:Cystic Fibrosis / Q000382:microbiology* / Q000601:surgery*; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D009164:Mycobacterium Infections / Q000150:complications* / Q000188:drug therapy; D020127:Recovery of Function; D019172:Transplantation Conditioning; D055815:Young Adult
D000900:Anti-Bacterial Agents