Maturation of Schaffer collateral synapses generates a phenotype of unreliable basal evoked release and very reliable facilitated release.
Short-term synaptic plasticity undergoes important age-dependent changes that have crucial implications during the development of the nervous system. Paired-pulse facilitation is a form of short-term synaptic plasticity by which the response to the second of two temporally-paired stimuli is larger and more reliable than the response to the first stimulus. In this study, a paired-pulse minimal stimulation technique was used to measure the probability and quantal amplitude of synaptic release at hippocampal synapses from 12-16-day-old (young) and 7-9-week-old (adult) rats. In order to assess the contribution of temperature-dependent processes, we carried out experiments at both room temperature and at near physiological temperature. We report here that neither temperature nor maturation affected the low basal evoked release probability and quantal amplitude of release. However, the warmer temperature revealed a unique developmental increase in facilitated evoked release probability and quantal amplitude of release. As a result, although both basal evoked release and facilitated release are rather unreliable in synapses from young animals, the maturation process at near physiological temperature generates a phenotype with unreliable basal evoked release and highly reliable facilitated release.
Schiess
Adrian R B
AR
Department of Neurosciences, University of New Mexico School of Medicine, Albuquerque, NM 87131, USA.
Scullin
Chessa
C
Partridge
L Donald
LD
D000818:Animals; D004558:Electric Stimulation; D006624:Hippocampus / Q000254:growth & development* / Q000502:physiology*; D066298:In Vitro Techniques; D008564:Membrane Potentials; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D018408:Patch-Clamp Techniques; D011336:Probability; D051381:Rats; D017207:Rats, Sprague-Dawley; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*; D013696:Temperature; D013997:Time Factors
J Physiol. 2006 Nov 1;576(Pt 3):833-47
16931546
Neuron. 1997 Jun;18(6):995-1008
9208866
J Neurophysiol. 2006 May;95(5):3024-34
16436482
J Physiol. 1997 Feb 1;498 ( Pt 3):763-72
9051587
Neuron. 1995 Apr;14(4):795-802
7718241
Annu Rev Neurosci. 1989;12:13-31
2648947
J Neurophysiol. 1997 Dec;78(6):2870-80
9405507
J Physiol. 1998 Jan 1;506 ( Pt 1):143-57
9481678
Nature. 1997 Aug 28;388(6645):874-8
9278048
J Physiol. 1998 Feb 15;507 ( Pt 1):219-36
9490842
Hippocampus. 2005;15(5):562-78
15884034
J Comp Neurol. 1997 Jul 28;384(2):165-80
9215716
Eur J Neurosci. 2010 Mar;31(5):817-26
20374283
Nature. 1995 Jun 1;375(6530):404-8
7760934
Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14843-7
9405701
J Neurophysiol. 2007 May;97(5):3460-72
17314237
J Neurophysiol. 2004 Nov;92(5):2714-24
15295011
J Neurophysiol. 2008 Feb;99(2):799-813
18032567
J Neurosci. 2006 Feb 1;26(5):1366-77
16452660
Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7834-8
1679238
Nature. 2003 Jun 5;423(6940):607-13
12789331
J Neurophysiol. 1999 Jan;81(1):288-98
9914289
J Neurosci. 2006 Jun 28;26(26):6945-57
16807324
Nat Rev Neurosci. 2002 Sep;3(9):728-39
12209121
Annu Rev Physiol. 2002;64:355-405
11826273
J Physiol. 2001 Mar 1;531(Pt 2):467-80
11230519
Science. 1995 Sep 22;269(5231):1730-4
7569903
J Physiol. 2004 May 15;557(Pt 1):3-12
15034124
J Neurosci. 2000 Dec 15;20(24):9162-73
11124994
Ann N Y Acad Sci. 1991;627:264-76
1652915
Proc Natl Acad Sci U S A. 1990 Jul;87(14):5359-62
2371276
J Physiol. 1996 Feb 15;491 ( Pt 1):163-76
9011608
Int J Dev Neurosci. 2002 Jun-Aug;20(3-5):225-36
12175858
J Neurosci. 1993 Sep;13(9):3736-48
8366344