title: One-pot multicomponent synthesis of two novel thiolactone scaffolds.
abstract: We designed two novel thiolactone scaffolds. Both scaffolds can be accessed by a convergent Ugi multicomponent reaction (MCR) and are, thus, amenable to library synthesis. Design, stereoselectivity, structures, full experimental details, and virtual libraries will be reported.
authors.affiliation: Department of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
authors.forename: B
authors.initials: B
authors.lastname: Beck
authors.forename: S
authors.initials: S
authors.lastname: Srivastava
authors.forename: K
authors.initials: K
authors.lastname: Khoury
authors.forename: E
authors.initials: E
authors.lastname: Herdtweck
authors.forename: Alexander
authors.initials: A
authors.lastname: Dömling
mesh_terms: D000215:Acylation; D002625:Chemistry, Organic / Q000379:methods*; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D009025:Morpholines / Q000138:chemical synthesis / Q000737:chemistry; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D007783:Lactones; D009025:Morpholines; D013876:Thiophenes; C028971:thiamorpholine
references.citation: J Am Chem Soc. 2002 Mar 20;124(11):2560-7
references.pmid: 11890807
references.citation: Mol Divers. 2003;6(3-4):193-7
references.pmid: 15068081
references.citation: Mol Divers. 2003;6(3-4):213-21
references.pmid: 15068084
references.citation: Chem Commun (Camb). 2008 Jan 14;(2):172-4
references.pmid: 18092077
references.citation: J Med Chem. 2003 Jan 2;46(1):97-104
references.pmid: 12502363
references.citation: Bioorg Med Chem Lett. 2006 Oct 1;16(19):5244-8
references.pmid: 16876404
references.citation: N Engl J Med. 2002 Feb 14;346(7):476-83
references.pmid: 11844848
references.citation: J Alzheimers Dis. 2007 Nov;12(3):241-3
references.pmid: 18057557
references.citation: Org Lett. 2003 Apr 3;5(7):1047-50
references.pmid: 12659570
references.citation: Chem Commun (Camb). 2006 Feb 14;(6):661-2
references.pmid: 16446843
references.citation: Drug Metab Dispos. 2007 Jul;35(7):1096-104
references.pmid: 17403916
references.citation: Org Lett. 2001 Mar 22;3(6):877-80
references.pmid: 11263905
references.citation: J Antibiot (Tokyo). 1982 Apr;35(4):396-400
references.pmid: 7096195
references.citation: Org Lett. 2001 Dec 27;3(26):4149-52
references.pmid: 11784164
references.citation: Life Sci. 1997;60(6):341-50
references.pmid: 9031679
references.citation: Pulm Pharmacol Ther. 2008;21(2):304-8
references.pmid: 17889580
references.citation: J Am Chem Soc. 2006 Jun 7;128(22):7122-3
references.pmid: 16734440
references.citation: Chem Rev. 2006 Jan;106(1):17-89
references.pmid: 16402771
references.citation: J Med Chem. 2001 Sep 13;44(19):3066-73
references.pmid: 11543675