[The morphological response of the pineal gland of old animals on course of melatonin injections].
On the old (18-20 months) male rats of Wistar population the influence of the 10 days evening melatonin injections in physiological rang doses on morphological state pineal gland, was studied. It has been shown, that the course of melatonin injections to old rats brings appearance of histological pattern of pineal gland activation: increasing of area of pinealocytes nuclear and density of nuclear and cytoplasm with stein by hallocyanine on total nucleic acid that means stimulation to material both indole, and peptide nature production. Using of melatonin in dose 0.05 mg/kg mass of the body is sparing for pinealocytes of the old rats and slows the apoptosis processes on background of polyploidization. Using of melatonin in dose 0,5 mg/kg mass of the body causes cell's overstrain and induces the forced apoptosis. It's possible to suppose that the geroprotective effect of the evening injections of melatonin is increased due to stimulation of the biosynthesis of neuropeptides in pineal gland.
Gubina-Vakulik
G I
GI
Bondarenko
L A
LA
Gevorkian
A R
AR
D000375:Aging / Q000473:pathology*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D010870:Pineal Gland / Q000187:drug effects* / Q000648:ultrastructure*; D011123:Polyploidy; D051381:Rats; D017208:Rats, Wistar
D008550:Melatonin