Relationship between epileptogenesis and morphological changes in the cerebral cortex.
The relationship between disorders in the cytoarchitectonics (microdysgenesis) and formation of epileptogenic zones was studied on clinical material. Results of surgical treatment of 29 patients with drug-resistant temporal epilepsy are presented. Intraoperative electrocorticography was carried out in all patients. Histological studies of the cortex from the zone of regular epileptic activity registration were carried out in 23 cases. A relationship between completeness of radical removal of the zone of regular epileptic activity and treatment results was detected. Histological studies of resected cortex revealed signs of microdysgenesis in all cases. The presence of similar changes in the zone of regular epileptic activity registration, resection of which is essential for attack control, suggests a pathogenetic relationship between microdysgenesis and generation of epileptic activity.
Stepanenko
A Yu
AY
N. N. Burdenko Institute of Neurosurgery, Russian Academy of Medical Sciences, Moscow, Russia. ast@nsi.ru
Arkhipova
N A
NA
Shishkina
L V
LV
D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000473:pathology* / Q000601:surgery; D004569:Electroencephalography / Q000379:methods; D004827:Epilepsy / Q000473:pathology* / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D055815:Young Adult