title: MicroRNAs in psychiatric and neurodevelopmental disorders.
abstract: Abnormalities in microRNA (miRNA)-mediated gene regulation have been observed in a variety of human diseases, especially in cancer. Here, we provide an account of newly emerging connections between miRNAs with various psychiatric and neurodevelopmental disorders, including recent findings of miRNA dysregulation in the 22q11.2 microdeletion syndrome, a well-established genetic risk factor for schizophrenia. miRNAs appear to be components of both the genetic architecture of these complex phenotypes as well as integral parts of the biological pathways that mediate the effects of primary genetic deficits. Therefore, they may contribute to both genetic heterogeneity and phenotypic variation of psychiatric and neurodevelopmental disorders and could serve as novel therapeutic targets.
authors.affiliation: Department of Physiology and Cellular Biophysics, Columbia University Medical Center, 630 W. 168th Street,New York, NY 10032, USA.
authors.forename: Bin
authors.initials: B
authors.lastname: Xu
authors.forename: Maria
authors.initials: M
authors.lastname: Karayiorgou
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Gogos
mesh_terms: D000818:Animals; D002658:Developmental Disabilities / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D001523:Mental Disorders / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000378:metabolism*; D008959:Models, Neurological; D009422:Nervous System Diseases / Q000235:genetics / Q000378:metabolism*
chemical_list: D035683:MicroRNAs
references.citation: Nat Neurosci. 2004 Feb;7(2):113-7
references.pmid: 14703574
references.citation: Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7612-6
references.pmid: 7644464
references.citation: Nat Neurosci. 2007 Dec;10(12):1513-4
references.pmid: 17994015
references.citation: J Neurosci. 2007 Mar 21;27(12):3120-30
references.pmid: 17376973
references.citation: Hum Mol Genet. 2008 Apr 15;17(8):1192-9
references.pmid: 18203756
references.citation: Science. 2005 Oct 14;310(5746):317-20
references.pmid: 16224024
references.citation: Nature. 2008 Sep 11;455(7210):237-41
references.pmid: 18668038
references.citation: Acta Neurol Scand. 2006 Dec;114(6):400-2
references.pmid: 17083340
references.citation: Hum Mol Genet. 2008 Apr 15;17(8):1156-68
references.pmid: 18184693
references.citation: EMBO J. 2009 Mar 18;28(6):697-710
references.pmid: 19197241
references.citation: Genes Dev. 2006 Aug 15;20(16):2202-7
references.pmid: 16882971
references.citation: Nature. 2005 Feb 17;433(7027):769-73
references.pmid: 15685193
references.citation: Proc Natl Acad Sci U S A. 2002 May 28;99(11):7746-50
references.pmid: 12032354
references.citation: Brain Dev. 1985;7(3):276-80
references.pmid: 3877471
references.citation: Nat Genet. 2007 Mar;39(3):380-5
references.pmid: 17259983
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2007 Jan 5;144B(1):27-36
references.pmid: 17034021
references.citation: Genes Cells. 2001 Apr;6(4):313-25
references.pmid: 11318874
references.citation: Biol Psychiatry. 2009 Jun 15;65(12):1006-14
references.pmid: 19121517
references.citation: J Neurosci. 2008 Apr 23;28(17):4322-30
references.pmid: 18434510
references.citation: Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16426-31
references.pmid: 16260724
references.citation: Science. 2008 Sep 12;321(5895):1490-2
references.pmid: 18787168
references.citation: Nature. 2009 May 28;459(7246):569-73
references.pmid: 19404257
references.citation: Ann Neurol. 1985 Mar;17(3):278-82
references.pmid: 3158266
references.citation: PLoS Genet. 2009 Jun;5(6):e1000536
references.pmid: 19557195
references.citation: Am J Med Genet. 1996 Jul 12;64(1):196-7
references.pmid: 8826475
references.citation: Genes Dev. 2002 Oct 1;16(19):2497-508
references.pmid: 12368261
references.citation: Biochem Biophys Res Commun. 2008 Jun 6;370(3):473-7
references.pmid: 18387358
references.citation: Curr Biol. 2002 Apr 30;12(9):735-9
references.pmid: 12007417
references.citation: Mol Psychiatry. 2006 Oct;11(10):954-64
references.pmid: 16894393
references.citation: Am J Hum Genet. 1998 Nov;63(5):1552-8
references.pmid: 9792883
references.citation: Nat Genet. 2008 Jun;40(6):751-60
references.pmid: 18469815
references.citation: Psychiatr Genet. 2009 Aug;19(4):177-85
references.pmid: 19407672
references.citation: J Exp Med. 2007 Jul 9;204(7):1553-8
references.pmid: 17606634
references.citation: Dev Dyn. 2006 Sep;235(9):2538-48
references.pmid: 16736490
references.citation: Am J Med Genet. 1994 Mar 15;54(1):36-43
references.pmid: 8178837
references.citation: Neuropsychologia. 2007 Sep 20;45(12):2863-73
references.pmid: 17618656
references.citation: J Psychosom Res. 2009 Dec;67(6):533-45
references.pmid: 19913658
references.citation: J Neuropathol Exp Neurol. 1995 Mar;54(2):195-201
references.pmid: 7876888
references.citation: Dev Med Child Neurol. 1998 Feb;40(2):115-21
references.pmid: 9489500
references.citation: Arch Gen Psychiatry. 1999 Oct;56(10):940-5
references.pmid: 10530637
references.citation: Behav Brain Funct. 2008 Feb 19;4:10
references.pmid: 18284679
references.citation: Cell. 2001 Nov 30;107(5):591-603
references.pmid: 11733059
references.citation: Neuron. 2009 Sep 24;63(6):803-17
references.pmid: 19778509
references.citation: Genome Biol. 2007;8(2):R27
references.pmid: 17326821
references.citation: Am J Hum Genet. 1992 Feb;50(2):278-87
references.pmid: 1734712
references.citation: Mol Psychiatry. 2010 Dec;15(12):1176-89
references.pmid: 19721432
references.citation: Nat Rev Mol Cell Biol. 2005 May;6(5):376-85
references.pmid: 15852042
references.citation: Exp Cell Res. 2008 Aug 15;314(14):2618-33
references.pmid: 18619591
references.citation: RNA. 2004 Oct;10(10):1518-25
references.pmid: 15337849
references.citation: Proc Natl Acad Sci U S A. 2008 Jul 1;105(26):9093-8
references.pmid: 18577589
references.citation: J Med Genet. 2009 Apr;46(4):242-8
references.pmid: 18805830
references.citation: Proc Natl Acad Sci U S A. 2006 Feb 14;103(7):2422-7
references.pmid: 16461918
references.citation: Nat Neurosci. 2009 Apr;12(4):399-408
references.pmid: 19287386
references.citation: J Child Psychol Psychiatry. 1989 May;30(3):405-16
references.pmid: 2745591
references.citation: J Psychosom Res. 2003 Jul;55(1):3-6
references.pmid: 12842225
references.citation: Compr Psychiatry. 1997 Jan-Feb;38(1):6-16
references.pmid: 8980866
references.citation: J Psychosom Res. 2009 Dec;67(6):515-23
references.pmid: 19913656
references.citation: Cell. 1993 Dec 3;75(5):843-54
references.pmid: 8252621
references.citation: Hum Genet. 1991 Apr;86(6):604-6
references.pmid: 1673961
references.citation: RNA. 2006 Jul;12(7):1161-7
references.pmid: 16738409
references.citation: Science. 2008 Mar 28;319(5871):1785-6
references.pmid: 18369135
references.citation: Nat Genet. 2008 Jul;40(7):880-5
references.pmid: 18511947
references.citation: Neuropsychopharmacology. 2009 May;34(6):1395-405
references.pmid: 18704095
references.citation: J Neuropsychiatry Clin Neurosci. 2009 Winter;21(1):13-23
references.pmid: 19359447
references.citation: Am J Hum Genet. 2008 Feb;82(2):477-88
references.pmid: 18252227
references.citation: J Clin Exp Neuropsychol. 2001 Aug;23(4):447-64
references.pmid: 11780945
references.citation: RNA. 2009 Jun;15(6):1005-11
references.pmid: 19383765
references.citation: Nature. 2006 Jan 19;439(7074):283-9
references.pmid: 16421561
references.citation: Mol Cell. 2007 Aug 3;27(3):435-48
references.pmid: 17679093
references.citation: Mol Psychiatry. 2006 Sep;11(9):802-4
references.pmid: 16936762
references.citation: Nat Genet. 1999 Oct;23(2):185-8
references.pmid: 10508514
references.citation: Eur J Hum Genet. 1993;1(2):114-24
references.pmid: 8055322
references.citation: Hum Mol Genet. 2006 Nov 15;15(22):3324-8
references.pmid: 17035247
references.citation: Ann Neurol. 1983 Oct;14(4):471-9
references.pmid: 6638958
references.citation: J Med Genet. 1999 May;36(5):386-93
references.pmid: 10353785
references.citation: J Biol Chem. 2010 Jan 8;285(2):1529-43
references.pmid: 19897480
references.citation: J Child Psychol Psychiatry. 1977 Sep;18(4):297-321
references.pmid: 562353
references.citation: Biol Psychiatry. 2008 Jun 15;63(12):1111-7
references.pmid: 18374305
references.citation: Brain Dev. 1992 May;14 Suppl:S11-20
references.pmid: 1378244
references.citation: Science. 2007 Aug 31;317(5842):1220-4
references.pmid: 17761882
references.citation: Nat Genet. 1993 Aug;4(4):335-40
references.pmid: 8401578
references.citation: Pediatr Neurol. 2007 Dec;37(6):404-6
references.pmid: 18021920
references.citation: Neuron. 2010 Feb 11;65(3):373-84
references.pmid: 20159450
references.citation: Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3507-12
references.pmid: 19196972
references.citation: Psychiatr Genet. 2008 Dec;18(6):308-9
references.pmid: 19018236
references.citation: Pediatrics. 2004 May;113(5):e472-86
references.pmid: 15121991
references.citation: Neuron. 2009 Nov 12;64(3):303-9
references.pmid: 19914179
references.citation: Cell. 2008 Sep 19;134(6):1042-54
references.pmid: 18805096
references.citation: N Engl J Med. 2008 Feb 14;358(7):667-75
references.pmid: 18184952
references.citation: Neurogenetics. 2008 Jul;9(3):153-61
references.pmid: 18563458
references.citation: Genes Dev. 2002 Oct 1;16(19):2491-6
references.pmid: 12368260
references.citation: J Neuropathol Exp Neurol. 2004 Jul;63(7):679-85
references.pmid: 15290893
references.citation: Genome Biol. 2006;7(9):R85
references.pmid: 17002790
references.citation: Neurology. 2008 Apr 15;70(16 Pt 2):1495-6
references.pmid: 18413575
references.citation: Science. 2004 Sep 3;305(5689):1437-41
references.pmid: 15284456
references.citation: Nature. 2008 Sep 11;455(7210):232-6
references.pmid: 18668039
references.citation: Nat Genet. 2007 Mar;39(3):319-28
references.pmid: 17322880
references.citation: Am J Hum Genet. 2001 Nov;69(5):1062-7
references.pmid: 11590546
references.citation: Science. 2005 May 6;308(5723):833-8
references.pmid: 15774722
references.citation: Dev Cell. 2008 Jun;14(6):926-39
references.pmid: 18539120
references.citation: Hum Mol Genet. 2008 Feb 15;17(4):628-38
references.pmid: 18156158
references.citation: J Physiol. 2009 Feb 15;587(Pt 4):787-804
references.pmid: 19103683
references.citation: J Neurochem. 2008 Jul;106(2):650-61
references.pmid: 18410515
references.citation: Annu Rev Genomics Hum Genet. 2007;8:109-29
references.pmid: 17477822
references.citation: Child Neuropsychol. 2005 Feb;11(1):39-53
references.pmid: 15823982
references.citation: CNS Drugs. 2004;18(11):687-703
references.pmid: 15330685
references.citation: Cell. 1991 May 31;65(5):905-14
references.pmid: 1710175
references.citation: Nat Rev Neurosci. 2009 Dec;10(12):842-9
references.pmid: 19888283
references.citation: Psychol Med. 1995 Jan;25(1):63-77
references.pmid: 7792363
references.citation: Nat Neurosci. 2008 Oct;11(10):1143-5
references.pmid: 18776892
references.citation: J Neurosci. 2008 Nov 12;28(46):11883-9
references.pmid: 19005053
references.citation: Science. 2007 Apr 20;316(5823):445-9
references.pmid: 17363630
references.citation: Annu Rev Neurosci. 2006;29:77-103
references.pmid: 16776580
references.citation: Hum Genet. 1993 Jan;90(5):551-5
references.pmid: 8094068
references.citation: RNA. 2009 Apr;15(4):537-45
references.pmid: 19223442
references.citation: Cell. 2009 Jan 9;136(1):75-84
references.pmid: 19135890
references.citation: Science. 2001 Aug 3;293(5531):834-8
references.pmid: 11452083
references.citation: Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12135-40
references.pmid: 16099834
references.citation: Am J Med Genet. 1996 Aug 9;64(2):388-94
references.pmid: 8844089
references.citation: PLoS One. 2007 Sep 12;2(9):e873
references.pmid: 17849003
references.citation: Autism Res. 2008 Aug;1(4):240-50
references.pmid: 19360674