title: The involvement of circulating microparticles in inflammation, coagulation and cardiovascular diseases.
abstract: Microparticles (MPs) are small vesicles, ranging in size from 0.1 microm to 2 microm, originating from plasma membranes of endothelial cells, platelets, leukocytes and erythrocytes. MPs can transfer antigens and receptors to cell types that are different from their cell of origin. Circulating MPs provide a procoagulant aminophospholipid surface for the assembly of the specific enzymes of coagulation. Both tissue factor and phosphatidylserine are exposed on MP outer membranes. In addition, MPs can play a significant role in vascular function and inflammation by modulating nitric oxide and prostacyclin production in endothelial cells, and stimulating cytokine release and tissue factor induction in endothelial cells, as well as monocyte chemotaxis and adherence to the endothelium. Finally, increased levels of MPs have been found in the presence of acute coronary syndromes, ischemic stroke, diabetes, systemic and pulmonary hypertension, and hypertriglyceridemia. From a practical point of view, MPs could be considered to be important markers of cardiovascular risk, as well as surrogate end points for assessing the efficacy of new drugs and therapies.
authors.affiliation: Department of Internal Medicine, University of Bologna and S Orsola-Malpighi Hospital, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Puddu
authors.forename: Giovanni M
authors.initials: GM
authors.lastname: Puddu
authors.forename: Eleonora
authors.initials: E
authors.lastname: Cravero
authors.forename: Silvia
authors.initials: S
authors.lastname: Muscari
authors.forename: Antonio
authors.initials: A
authors.lastname: Muscari
mesh_terms: D001777:Blood Coagulation / Q000502:physiology*; D001792:Blood Platelets / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000097:blood; D002462:Cell Membrane / Q000502:physiology; D055252:Cell-Derived Microparticles / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000097:blood*; D010974:Platelet Aggregation / Q000502:physiology; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors
references.citation: Acad Emerg Med. 2007 Aug;14(8):685-90
references.pmid: 17606807
references.citation: J Clin Invest. 1999 Jul;104(1):93-102
references.pmid: 10393703
references.citation: J Thromb Haemost. 2009 Jan;7(1):190-7
references.pmid: 18983485
references.citation: J Am Soc Nephrol. 2005 Nov;16(11):3381-8
references.pmid: 16192427
references.citation: J Thromb Thrombolysis. 2004 Dec;18(3):177-85
references.pmid: 15815879
references.citation: Blood. 1997 Feb 15;89(4):1121-32
references.pmid: 9028933
references.citation: Clin Appl Thromb Hemost. 2004 Apr;10(2):167-73
references.pmid: 15094937
references.citation: J Thromb Haemost. 2004 Jul;2(7):1215-6
references.pmid: 15219224
references.citation: Pharmacol Rep. 2008 Jan-Feb;60(1):75-84
references.pmid: 18276988
references.citation: Am J Pathol. 2008 Oct;173(4):1210-9
references.pmid: 18772329
references.citation: Thromb Haemost. 1998 Sep;80(3):388-92
references.pmid: 9759615
references.citation: Am J Physiol Heart Circ Physiol. 2004 May;286(5):H1910-5
references.pmid: 15072974
references.citation: J Biol Chem. 1992 Jul 25;267(21):15168-75
references.pmid: 1321830
references.citation: Cardiovasc Res. 1999 Jun;42(3):783-93
references.pmid: 10533619
references.citation: Nat Rev Immunol. 2002 Aug;2(8):569-79
references.pmid: 12154376
references.citation: Arterioscler Thromb Vasc Biol. 2005 Jul;25(7):1512-8
references.pmid: 15890969
references.citation: Curr Opin Hematol. 2004 May;11(3):156-64
references.pmid: 15257014
references.citation: J Clin Invest. 1997 May 1;99(9):2118-27
references.pmid: 9151784
references.citation: J Thromb Haemost. 2003 Sep;1(9):2022-30
references.pmid: 12941046
references.citation: Mol Cell Proteomics. 2009 Apr;8(4):799-804
references.pmid: 19095623
references.citation: Ann Cardiol Angeiol (Paris). 2008 Jun;57(3):149-54
references.pmid: 18579117
references.citation: Platelets. 2008 Aug;19(5):365-72
references.pmid: 18791943
references.citation: Physiology (Bethesda). 2005 Feb;20:22-7
references.pmid: 15653836
references.citation: PPAR Res. 2008;2008:245410
references.pmid: 18288280
references.citation: Nat Cell Biol. 2001 Apr;3(4):339-45
references.pmid: 11283606
references.citation: Diabetes. 2002 Sep;51(9):2840-5
references.pmid: 12196479
references.citation: Hypertension. 2003 Feb;41(2):211-7
references.pmid: 12574084
references.citation: J Pharmacol Exp Ther. 2008 Feb;324(2):539-47
references.pmid: 18039959
references.citation: J Am Coll Cardiol. 2005 May 17;45(10):1622-30
references.pmid: 15893178
references.citation: Circulation. 2004 Dec 7;110(23):3599-603
references.pmid: 15569844
references.citation: Atherosclerosis. 2001 Oct;158(2):277-87
references.pmid: 11583705
references.citation: Am J Pathol. 1981 Apr;103(1):47-55
references.pmid: 7013494
references.citation: J Thromb Haemost. 2003 Dec;1(12):2561-8
references.pmid: 14738565
references.citation: Blood Rev. 2007 May;21(3):157-71
references.pmid: 17118501
references.citation: Br J Haematol. 1967 May;13(3):269-88
references.pmid: 6025241
references.citation: Hypertension. 2006 Aug;48(2):180-6
references.pmid: 16801490
references.citation: Thromb Haemost. 2001 Apr;85(4):639-46
references.pmid: 11341498
references.citation: J Thromb Haemost. 2003 Nov;1(11):2434-43
references.pmid: 14629480
references.citation: Pathophysiol Haemost Thromb. 2006;35(1-2):15-22
references.pmid: 16855341
references.citation: J Clin Pathol. 1953 Feb;6(1):9-14
references.pmid: 13034912
references.citation: J Immunol. 1998 Oct 15;161(8):4382-7
references.pmid: 9780216
references.citation: Platelets. 2002 Jun;13(4):247-53
references.pmid: 12189027
references.citation: Biochemistry. 1988 Jan 12;27(1):8-11
references.pmid: 3162382
references.citation: Clin Appl Thromb Hemost. 2004 Apr;10(2):133-41
references.pmid: 15094933
references.citation: Br J Haematol. 2007 Apr;137(1):36-48
references.pmid: 17359370
references.citation: Vasc Health Risk Manag. 2008;4(4):769-74
references.pmid: 19065994
references.citation: J Clin Invest. 1998 Jul 1;102(1):136-44
references.pmid: 9649567
references.citation: Blood. 2005 Sep 1;106(5):1604-11
references.pmid: 15741221
references.citation: Blood. 2000 Feb 15;95(4):1317-23
references.pmid: 10666205
references.citation: Diabetologia. 2002 Jun;45(6):805-12
references.pmid: 12107724
references.citation: Biochemistry. 1991 Feb 5;30(5):1163-73
references.pmid: 1991095
references.citation: J Thromb Haemost. 2004 Oct;2(10):1842-51
references.pmid: 15456497
references.citation: J Biol Chem. 1999 Aug 13;274(33):23111-8
references.pmid: 10438480
references.citation: J Immunol. 1994 Oct 1;153(7):3245-55
references.pmid: 7522256
references.citation: Cell Death Differ. 1998 Jul;5(7):551-62
references.pmid: 10200509
references.citation: Blood. 1999 Jun 15;93(12):4222-31
references.pmid: 10361119
references.citation: Subcell Biochem. 1983;9:299-334
references.pmid: 6344351
references.citation: Blood. 2003 Oct 1;102(7):2678-83
references.pmid: 12805058
references.citation: Haematologica. 2008 Jun;93(6):892-9
references.pmid: 18469350
references.citation: Nat Med. 2003 Aug;9(8):1020-5
references.pmid: 12858167
references.citation: J Thromb Haemost. 2006 Jun;4(6):1296-302
references.pmid: 16706974
references.citation: Platelets. 2009 Feb;20(1):16-22
references.pmid: 19172517
references.citation: Prog Lipid Res. 2003 Sep;42(5):423-38
references.pmid: 12814644
references.citation: Ann Pharm Fr. 2007 Mar;65(2):75-84
references.pmid: 17404540
references.citation: J Biol Chem. 1990 Mar 5;265(7):3809-14
references.pmid: 2105954
references.citation: Subcell Biochem. 2007;43:21-34
references.pmid: 17953389
references.citation: J Biol Chem. 1989 Oct 15;264(29):17049-57
references.pmid: 2793843
references.citation: Am J Cardiol. 1997 Feb 1;79(3):350-4
references.pmid: 9036757
references.citation: Am J Respir Crit Care Med. 2008 Mar 1;177(5):536-43
references.pmid: 18006886
references.citation: J Biol Chem. 1999 Mar 12;274(11):7545-56
references.pmid: 10066822
references.citation: J Am Coll Nutr. 2001 Apr;20(2 Suppl):97-105
references.pmid: 11349944
references.citation: Crit Rev Oncol Hematol. 1999 Apr;30(2):111-42
references.pmid: 10439058
references.citation: Thromb Haemost. 2008 Aug;100(2):280-5
references.pmid: 18690348
references.citation: Semin Thromb Hemost. 2007 Nov;33(8):771-9
references.pmid: 18175282
references.citation: Arterioscler Thromb Vasc Biol. 2002 Jan;22(1):101-7
references.pmid: 11788468
references.citation: J Biol Chem. 1981 Apr 10;256(7):3433-42
references.pmid: 6782101
references.citation: Am J Hypertens. 2004 Sep;17(9):757-63
references.pmid: 15363816
references.citation: Eur J Clin Invest. 2004 Jun;34(6):392-401
references.pmid: 15200490
references.citation: Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2594-604
references.pmid: 16990554
references.citation: Tissue Antigens. 1997 Nov;50(5):449-58
references.pmid: 9389318
references.citation: J Thromb Haemost. 2003 Jul;1(7):1655-62
references.pmid: 12871302
references.citation: Stroke. 2003 Sep;34(9):2132-7
references.pmid: 12907813
references.citation: Circulation. 1999 Jan 26;99(3):348-53
references.pmid: 9918520
references.citation: J Exp Med. 2003 Jun 2;197(11):1585-98
references.pmid: 12782720
references.citation: J Am Coll Cardiol. 2007 Feb 20;49(7):772-7
references.pmid: 17306706
references.citation: Thromb Res. 2008;122 Suppl 1:S55-9
references.pmid: 18691501
references.citation: Thromb Haemost. 2007 Jul;98(1):38-42
references.pmid: 17597988
references.citation: Recent Pat Cardiovasc Drug Discov. 2007 Jan;2(1):41-51
references.pmid: 18221102
references.citation: Cardiovasc Res. 2003 Aug 1;59(2):277-87
references.pmid: 12909311
references.citation: Circulation. 2000 Feb 29;101(8):841-3
references.pmid: 10694520
references.citation: Eur J Biochem. 1982 Feb;122(2):429-36
references.pmid: 7060583
references.citation: J Intern Med. 2008 May;263(5):528-37
references.pmid: 18410596
references.citation: Thromb Res. 2003 Jun 01;110(4):173-80
references.pmid: 14512078
references.citation: Circulation. 2002 Nov 5;106(19):2442-7
references.pmid: 12417540
references.citation: J Thromb Haemost. 2005 Jun;3(6):1301-8
references.pmid: 15946221
references.citation: Cell Tissue Res. 2009 Jan;335(1):143-51
references.pmid: 18989704
references.citation: Arterioscler Thromb Vasc Biol. 2006 Aug;26(8):1926
references.pmid: 16857960
references.citation: FASEB J. 2007 Sep;21(11):2735-41
references.pmid: 17428963
references.citation: Circulation. 2001 Oct 30;104(18):2182-7
references.pmid: 11684628
references.citation: Cell Mol Life Sci. 2007 Apr;64(7-8):999-1008
references.pmid: 17372676
references.citation: Arterioscler Thromb Vasc Biol. 2006 Jan;26(1):112-6
references.pmid: 16239600
references.citation: Int J Cardiol. 2004 Dec;97(3):439-46
references.pmid: 15561331
references.citation: Br J Haematol. 2001 Jan;112(1):81-90
references.pmid: 11167788
references.citation: Immunity. 2001 Nov;15(5):825-35
references.pmid: 11728343
references.citation: Am J Physiol Heart Circ Physiol. 2005 Mar;288(3):H1004-9
references.pmid: 15706036