Antiulcer activity of preparations containing ultralow doses of antibodies in modeled chronic ulcer in rats.
Screening of three potential antiulcer preparations containing ultralow doses of antibodies to endogenous regulators of ulcer formation (gastrin, histamine, and H2 histamine receptors) on the model of acetic acid-induced gastric ulcer in rats revealed pronounced antiulcer effect of ultralow doses of antibodies to histamine. The dynamics of regeneration of the ulcer focus by morphological and histological characteristics was similar during treatment with ultralow doses of antibodies to histamine and with famotidine.
Tolstikova
T G
TG
N N Vorozhtsov Institute of Organic Chemistry, Siberian Division of Russian Academy of Sciences, Novosibirsk.
Zhukova
N A
NA
Sorokina
I V
IV
Dolgikh
M P
MP
Ogorodnikova
T V
TV
Borodavkina
M V
MV
Dugina
Yu L
YL
Sergeeva
S A
SA
D000085:Acetates / Q000633:toxicity; D000818:Animals; D000897:Anti-Ulcer Agents / Q000276:immunology* / Q000627:therapeutic use*; D000906:Antibodies / Q000276:immunology* / Q000627:therapeutic use*; D015738:Famotidine / Q000627:therapeutic use; D005755:Gastrins / Q000276:immunology; D006632:Histamine / Q000276:immunology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011970:Receptors, Histamine H2 / Q000276:immunology; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000085:Acetates; D000897:Anti-Ulcer Agents; D000906:Antibodies; D005755:Gastrins; D011970:Receptors, Histamine H2; D015738:Famotidine; D006632:Histamine