[Concept and clinical significance of subclinical Cushing syndrome].
The clinical significance of subclinical Cushing syndrome has been widely recognized because of its high prevalence in adrenal incidentaloma. Circulatory and metabolic disorders are the most frequent and important complications of the disease state. Since those complications show aggravation during the clinical course and improvement after surgery, appropriate diagnosis and treatment are essential. Diagnostic criteria, especially the cutoff value of plasma cortisol after dexamethasone suppression, are markedly affected by the sensitivity and specificity of cortisol assay methods. Revision of the diagnostic criteria should reflect the prognosis of the disease state.
Naruse
Mitsuhide
M
Department of Endocrinology, Metabolism, and Hypertension, National Hospital Organization, Kyoto Medical Center, Kyoto 612-8555, Japan. mtsnaruse@aol.jp
Tanabe
Akiyo
A
Tsuiki
Mika
M
D000310:Adrenal Gland Neoplasms; D015415:Biomarkers / Q000097:blood; D015897:Comorbidity; D003480:Cushing Syndrome / Q000175:diagnosis / Q000453:epidemiology / Q000601:surgery; D003907:Dexamethasone; D044882:Glucose Metabolism Disorders / Q000453:epidemiology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006949:Hyperlipidemias / Q000453:epidemiology; D006973:Hypertension / Q000453:epidemiology; D033162:Incidental Findings; D009765:Obesity / Q000453:epidemiology; D015995:Prevalence; D012015:Reference Standards
D015415:Biomarkers; D003907:Dexamethasone; D006854:Hydrocortisone