title: Prevalence of gestational fasting and postload single dysglycemia in Mexican-American women and their relative significance in identifying carbohydrate intolerance.
abstract: This study investigated the prevalence of gestational dysglycemia in a largely Hispanic population in a U.S.-Mexico border city and the influence of single plasma glucose (PG) result on the identification of gestational carbohydrate intolerance. Gestational dysglycemia was studied in a largely Mexican-American population using retrospective data. Gestational diabetes (GDM), gestational impaired fasting glucose (GIFG), and gestational impaired glucose tolerance (GIGT) were identified with Carpenter-Coustan thresholds. Glucose challenge test result was abnormal in 32.7% of 18307 women screened; 47% of them had one or more dysglycemic results in the confirmatory oral glucose tolerance test (OGTT). The prevalence of GDM, GIFG, and GIGT in these women was 8.7, 2.2, and 4.5%, respectively. Fasting, 1-hour, 2-hour, and 3-hour PGs were elevated in 20.5, 28.5, 25.0, and 15.0% of OGTT, respectively (GIFG: 6.0%; 1-hour GIGT: 6.5%; 2-hour GIGT: 4.4%; and 3-hour GIGT: 3.1%). Twelve percent of OGTTs showed dysglycemia at 1 hour with normal 2-hour PG. Isolated dysglycemia, similar to GDM, is prevalent in Mexican-American women. The minimal impact of 3-hour PG supports a 2-hour OGTT. But our results question the use of an "OGTT protocol without a first-hour specimen."
authors.affiliation: Department of Pathology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, Texas 79905, USA. ramaswami.kalameham@ttuhsc.edu
authors.forename: Ramaswami
authors.initials: R
authors.lastname: Kalamegham
authors.forename: Bahij S
authors.initials: BS
authors.lastname: Nuwayhid
authors.forename: Zuber D
authors.initials: ZD
authors.lastname: Mulla
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D016640:Diabetes, Gestational / Q000097:blood / Q000208:ethnology; D005215:Fasting; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000208:ethnology / Q000503:physiopathology; D044882:Glucose Metabolism Disorders / Q000097:blood / Q000208:ethnology*; D005951:Glucose Tolerance Test; D006801:Humans; D017058:Mexican Americans; D008800:Mexico / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000208:ethnology*; D015995:Prevalence; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D001786:Blood Glucose