title: Genetic mapping of quantitative trait loci for milk production in sheep.
abstract: A backcross pedigree using dairy East Friesian rams and non-dairy Dorset ewes was established specifically to map quantitative trait loci (QTL) affecting milk production in sheep. Ninety nine microsatellite markers of an initial set of 120 were successfully genotyped and informative on 188 animals of this backcross pedigree. Test-day milk records on individual ewes were used to estimate several milk yield related traits, including peak milk yield and cumulative milk yield to 50 (MY50), 100 (MY100) and 250 days (MY250). These traits, as well as estimated breeding value of backcross ewes extracted from the genetic evaluation file of the entire flock, were used in interval mapping. Ovine chromosomes 2, 12, 18, 20 and 24 were identified to harbour putative QTL for different measures of milk production. The QTL on Ovis aries chromosomes (OAR) 2 and 20 mapped to locations where similar trait QTL have already been mapped in other studies, whereas QTL on OAR 12, 18 and 24 were unique to our backcross pedigree and have not been reported previously. In addition, all identified QTL regions were syntenic with bovine chromosomal segments revealed to harbour QTL affecting milk production traits, providing supporting evidence for the QTL identified here.
authors.affiliation: Department of Animal Science, Oklahoma State University, Stillwater, OK 74078, USA. raluca@okstate.edu
authors.forename: R G
authors.initials: RG
authors.lastname: Mateescu
authors.forename: M L
authors.initials: ML
authors.lastname: Thonney
mesh_terms: D000818:Animals; D002417:Cattle; D002611:Cheese / Q000191:economics; D003433:Crosses, Genetic; D005260:Female; D007774:Lactation / Q000235:genetics*; D008297:Male; D008892:Milk / Q000191:economics / Q000502:physiology; D010375:Pedigree; D040641:Quantitative Trait Loci; D019655:Quantitative Trait, Heritable; D034561:Sheep, Domestic / Q000235:genetics*; D026801:Synteny; D014481:United States