title: Chronic caffeine treatment prevents sleep deprivation-induced impairment of cognitive function and synaptic plasticity.
abstract: OBJECTIVE
  This study was undertaken to provide a detailed account of the effect of chronic treatment with a small dose of caffeine on the deleterious effects of sleep loss on brain function in rats.
  
  
  METHODS
  We investigated the effects of chronic (4 weeks) caffeine treatment (0.3 g/L in drinking water) on memory impairment in acutely (24 h) sleep-deprived adult male Wistar rats. Sleep deprivation was induced using the modified multiple platform model. The effects of caffeine on sleep deprivation-induced hippocampus-dependent learning and memory deficits were studied by 3 approaches: learning and memory performance in the radial arm water maze task, electrophysiological recording of early long-term potentiation (E-LTP) in area CA1 of the hippocampus, and levels of memory- and synaptic plasticity-related signaling molecules after E-LTP induction.
  
  
  RESULTS
  The results showed that chronic caffeine treatment prevented impairment of hippocampus-dependent learning, shortterm memory and E-LTP of area CA1 in the sleep-deprived rats. In correlation, chronic caffeine treatment prevented sleep deprivation-associated decrease in the levels of phosphorylated calcium/calmodulin-dependent protein kinase II (P-CaMKII) during expression of E-LTP.
  
  
  CONCLUSIONS
  The results suggest that long-term use of a low dose of caffeine prevents impairment of short-term memory and E-LTP in acutely sleep-deprived rats.
authors.affiliation: Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Houston, TX 77204-5515, USA.
authors.forename: Ibrahim A
authors.initials: IA
authors.lastname: Alhaider
authors.forename: Abdulaziz M
authors.initials: AM
authors.lastname: Aleisa
authors.forename: Trinh T
authors.initials: TT
authors.lastname: Tran
authors.forename: Karem H
authors.initials: KH
authors.lastname: Alzoubi
authors.forename: Karim A
authors.initials: KA
authors.lastname: Alkadhi
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000097:blood / Q000187:drug effects; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000494:pharmacology*; D003072:Cognition Disorders / Q000209:etiology / Q000517:prevention & control*; D004195:Disease Models, Animal; D055724:Electrophysiological Phenomena / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects; D007858:Learning / Q000187:drug effects; D017774:Long-Term Potentiation / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008570:Memory, Short-Term / Q000187:drug effects; D009473:Neuronal Plasticity / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D012892:Sleep Deprivation / Q000150:complications*; D013569:Synapses / Q000187:drug effects*; D013647:Task Performance and Analysis
chemical_list: D000697:Central Nervous System Stimulants; D002110:Caffeine; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2
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