title: Cembranoids from the soft corals Sinularia granosa and Sinularia querciformis.
abstract: Two new cembranoids, namely granosolides C (1) and D (2), along with one known cembranoid 4, were isolated from the soft coral Sinularia granosa. Chemical investigation of Sinularia querciformis also afforded one new cembranoid, querciformolide E (3), along with four known cembranoids 4-7. The structures of these compounds were elucidated on the basis of their spectroscopic data. Both 4 and 5 were shown to significantly inhibit the accumulation of the pro-inflammatory inducible nitric oxide synthase protein in lipopolysaccharide-stimulated RAW264.7 macrophage cells.
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
authors.forename: Yi
authors.initials: Y
authors.lastname: Lu
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.forename: Chiung-Yao
authors.initials: CY
authors.lastname: Huang
authors.forename: Yung-Chun
authors.initials: YC
authors.lastname: Liu
authors.forename: Yao-Haur
authors.initials: YH
authors.lastname: Kuo
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Wen
authors.forename: Chi-Hsin
authors.initials: CH
authors.lastname: Hsu
authors.forename: Jyh-Horng
authors.initials: JH
authors.lastname: Sheu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002460:Cell Line; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D051546:Cyclooxygenase 2 / Q000276:immunology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D015394:Molecular Structure; D019001:Nitric Oxide Synthase / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D004224:Diterpenes; D008070:Lipopolysaccharides; D019001:Nitric Oxide Synthase; D051546:Cyclooxygenase 2