An extended multisensory temporal binding window in autism spectrum disorders.
Autism spectrum disorders (ASD) form a continuum of neurodevelopmental disorders, characterized by deficits in communication and reciprocal social interaction, as well as by repetitive behaviors and restricted interests. Sensory disturbances are also frequently reported in clinical and autobiographical accounts. However, surprisingly few empirical studies have characterized the fundamental features of sensory and multisensory processing in ASD. The current study is structured to test for potential differences in multisensory temporal function in ASD by making use of a temporally dependent, low-level multisensory illusion. In this illusion, the presentation of a single flash of light accompanied by multiple sounds often results in the illusory perception of multiple flashes. By systematically varying the temporal structure of the audiovisual stimuli, a "temporal window" within which these stimuli are likely to be bound into a single perceptual entity can be defined. The results of this study revealed that children with ASD report the flash-beep illusion over an extended range of stimulus onset asynchronies relative to children with typical development, suggesting that children with ASD have altered multisensory temporal function. These findings provide valuable new insights into our understanding of sensory processing in ASD and may hold promise for the development of more sensitive diagnostic measures and improved remediation strategies.
Foss-Feig
Jennifer H
JH
Department of Psychology and Human Development, Vanderbilt University, Nashville, TN 37232, USA.
Kwakye
Leslie D
LD
Cascio
Carissa J
CJ
Burnette
Courtney P
CP
Kadivar
Haleh
H
Stone
Wendy L
WL
Wallace
Mark T
MT
D000161:Acoustic Stimulation; D000293:Adolescent; D000704:Analysis of Variance; D001288:Attention / Q000502:physiology; D001307:Auditory Perception / Q000502:physiology*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007088:Illusions / Q000502:physiology*; D008297:Male; D009483:Neuropsychological Tests; D010775:Photic Stimulation; D011930:Reaction Time / Q000502:physiology; D013997:Time Factors; D014796:Visual Perception / Q000502:physiology*
Acta Paedopsychiatr. 1968;35(4):100-36
4880460
Exp Brain Res. 2005 Oct;166(3-4):474-80
16028030
J Child Psychol Psychiatry. 2006 Jun;47(6):591-601
16712636
J Autism Dev Disord. 2006 Jan;36(1):77-90
16395537
Brain Res Cogn Brain Res. 2002 Jun;14(1):147-52
12063138
Biol Psychiatry. 2003 Sep 15;54(6):647-54
13129660
Am J Occup Ther. 1997 Jul-Aug;51(7):530-7
9242859
J Autism Dev Disord. 1997 Jun;27(3):283-93
9229259
J Autism Dev Disord. 2007 Nov;37(10):2014-9
17273934
J Autism Dev Disord. 2000 Oct;30(5):415-21
11098877
J Autism Dev Disord. 1991 Sep;21(3):303-13
1938776
Am J Occup Ther. 2001 Jul-Aug;55(4):416-23
11723986
J Autism Dev Disord. 2007 May;37(5):894-910
17016677
J Child Psychol Psychiatry. 2008 Sep;49(9):995-1000
18492039
Dyslexia. 2003 Feb;9(1):37-45
12625375
J Autism Dev Disord. 2008 Sep;38(8):1485-98
18302014
Br J Psychol. 2004 Aug;95(Pt 3):269-82
15296535
J Child Psychol Psychiatry. 2006 Jan;47(1):88-98
16405645
J Neurosci. 2009 Sep 30;29(39):12265-74
19793985
Neuroimage. 2006 Jan 15;29(2):475-84
16115783
J Autism Dev Disord. 2000 Jun;30(3):205-23
11055457
J Speech Lang Hear Res. 2006 Oct;49(5):1104-13
17077218
Trends Neurosci. 2008 Aug;31(8):401-9
18602171
Ment Retard Dev Disabil Res Rev. 2002;8(3):151-61
12216059
J Autism Dev Disord. 2006 Jul;36(5):665-75
16639532
PLoS One. 2007 Sep 26;2(9):e943
17895984
Dev Psychopathol. 2002 Spring;14(2):209-24
12030688
Brain. 2005 Oct;128(Pt 10):2430-41
15958508
Res Dev Disabil. 2004 Nov-Dec;25(6):559-75
15541632
J Autism Dev Disord. 2008 Aug;38(7):1349-58
18307027
Child Dev. 1985 Jun;56(3):614-20
4006570
Curr Biol. 2004 Feb 3;14(3):257-62
14761661
J Autism Dev Disord. 2006 Jan;36(1):27-43
16453071
J Cogn Neurosci. 2003 Feb 15;15(2):226-35
12676060
J Child Psychol Psychiatry. 2007 Aug;48(8):813-21
17683453
J Autism Dev Disord. 1994 Oct;24(5):659-85
7814313
Nature. 2000 Dec 14;408(6814):788
11130706
J Autism Dev Disord. 2008 Jan;38(1):127-37
17415630
J Autism Dev Disord. 2003 Dec;33(6):631-42
14714932
Nature. 2002 Jan 24;415(6870):429-33
11807554
Genes Brain Behav. 2003 Oct;2(5):255-67
14606691