Serum lipoprotein levels in patients with neuromyelitis optica elevated but had little correlation with clinical presentations.
OBJECTIVE
To explore the relationship between serum lipoproteins and clinical presentations of NMO patients. To investigate the differences of serum lipoprotein levels between NMO and MS patients.


METHODS
Serum lipoprotein levels were measured in 56 NMO patients, 53 MS patients and 54 health subjects. Serum lipoprotein levels in all participants and relevant clinical parameters of NMO patients were investigated. Statistical analyses were performed using the SPSS statistical software.


RESULTS
NMO patients had significantly higher serum cholesterol (TC), triglyceride, low-density lipoprotein cholesterol, apolipoprotein B (apoB), lipoprotein (a) levels and TC/HDL-C, apoB/apoA-1 ratios than health control group. NMO patients had significantly higher serum apoB level and apoB/apoA-1 ratio than MS patients. There was little correlation between serum lipoproteins and NMO presentations.


CONCLUSIONS
The elevated lipoprotein levels in NMO patients could be just secondary changes with limited value in clinical prediction. However, elevated apoB level and apoB/apoA-1 ratio in NMO might indicate severer disability and might provide some useful information in the differential diagnosis with MS.
Li
Ying
Y
Department of Neurology, the Third Affiliated Hospital of Sun Yat-sen University, 600# Tianhe Road, Guangzhou, Guangdong 510630, China.
Wang
Honghao
H
Hu
Xueqiang
X
Peng
Fuhua
F
Yang
Yu
Y
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood; D009471:Neuromyelitis Optica / Q000097:blood* / Q000473:pathology*; D012008:Recurrence; D012727:Sex Characteristics; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
D008078:Cholesterol, LDL; D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol