New insights into p53 activation.
The tumor suppressor p53 is a multifunctional, highly regulated, and promoter-specific transcriptional factor that is uniquely sensitive to DNA damage and cellular stress signaling. The mechanisms by which p53 directs a damaged cell down either a cell growth arrest or an apoptotic pathway remain poorly understood. Evidence suggests that the in vivo functions of p53 seem to balance the cell-fate choice with the type and severity of damage that occurs. The concept of antirepression, or inhibition of factors that normally keep p53 at bay, may help explain the physiological mechanisms for p53 activation. These factors also provide novel chemotherapeutic targets for the reactivation of p53 in tumors harboring a wild-type copy of the gene.
Brooks
Christopher L
CL
Stemline Therapeutics, Inc., Suite 34-L, New York, NY 10128, USA. cbrooks@stemline.com
Gu
Wei
W
D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D004249:DNA Damage / Q000235:genetics; D006131:Growth Inhibitors / Q000235:genetics; D006801:Humans; D012097:Repressor Proteins / Q000235:genetics*; D015533:Transcriptional Activation / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism*
D006131:Growth Inhibitors; D012097:Repressor Proteins; D016159:Tumor Suppressor Protein p53
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