title: Effects of periarticular steroid injection on knee function and the inflammatory response following Unicondylar Knee Arthroplasty.
abstract: There is little information on the values of CRP and ESR as markers for inflammation in Unicondylar Knee Arthroplasty. The effect of periarticular steroid injection in post-operative pain relief and clinical recovery has not been well studied. Eighty-three consecutive patients undergoing primary UKAs were randomized to receive either an intra-operative periarticular injection with a local anaesthetic and adrenaline or with the addition of triamcinolone acetonide. CRP and ESR values, pain VAS and other scores, as well as clinical functional parameters, were obtained and analysed. Patients were assessed daily till discharge and up to 6 months post-operatively. Plasma CRP and ESR fluctuate after a UKA, with normalizing values indicating uneventful recovery. Periarticular steroid injections reduce post-operative pain and inflammation, and are clinically relevant as they improve short-term functional recovery and clinical parameters, resulting in better outcomes for patients without having major complications.
authors.affiliation: Department of Orthopaedic Surgery, Block 6 Level 7, Singapore General Hospital, Outram Road, Singapore 169608, Singapore. seanng31@gmail.com
authors.forename: Yung Chuan Sean
authors.initials: YC
authors.lastname: Ng
authors.forename: Ngai Nung
authors.initials: NN
authors.lastname: Lo
authors.forename: Kuang Ying
authors.initials: KY
authors.lastname: Yang
authors.forename: Shi Lu
authors.initials: SL
authors.lastname: Chia
authors.forename: Hwei Chi
authors.initials: HC
authors.lastname: Chong
authors.forename: Seng Jin
authors.initials: SJ
authors.lastname: Yeo
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D010147:Pain Measurement; D011184:Postoperative Period; D016059:Range of Motion, Articular; D020127:Recovery of Function; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
chemical_list: D002097:C-Reactive Protein; D014222:Triamcinolone Acetonide
references.citation: Surg Technol Int. 2003;11:282-6
references.pmid: 12931312
references.citation: Anaesthesia. 2007 Sep;62(9):888-94
references.pmid: 17697214
references.citation: J Bone Joint Surg Am. 2008 Jan;90(1):2-9
references.pmid: 18171951
references.citation: Ann Readapt Med Phys. 2008 Jun;51(5):348-57
references.pmid: 18547673
references.citation: J Int Med Res. 2001 Jan-Feb;29(1):7-12
references.pmid: 11277348
references.citation: Instr Course Lect. 2004;53:265-83
references.pmid: 15116621
references.citation: Knee Surg Sports Traumatol Arthrosc. 2007 Aug;15(8):1028-34
references.pmid: 17497127
references.citation: J Knee Surg. 2002 Winter;15(1):17-22
references.pmid: 11829329
references.citation: Singapore Med J. 2003 Nov;44(11):559-62
references.pmid: 15007494
references.citation: Thromb Haemost. 1982 Aug 24;48(1):6-8
references.pmid: 7135344
references.citation: Arch Gerontol Geriatr. 2005 Sep-Oct;41(2):169-76
references.pmid: 16085068
references.citation: Ann Rheum Dis. 2001 Mar;60(3):275-7
references.pmid: 11171691
references.citation: Knee Surg Sports Traumatol Arthrosc. 2005 Apr;13(3):179-86
references.pmid: 15175850
references.citation: Anesth Analg. 2008 Apr;106(4):1253-7, table of contents
references.pmid: 18349202
references.citation: Acta Orthop. 2008 Aug;79(4):499-507
references.pmid: 18766483
references.citation: J Int Med Res. 2006 Nov-Dec;34(6):603-11
references.pmid: 17294992
references.citation: Int Orthop. 2007 Jun;31(3):315-9
references.pmid: 16896871
references.citation: Clin Orthop Relat Res. 2001 Nov;(392):226-31
references.pmid: 11716387
references.citation: Clin Orthop Relat Res. 1995 Aug;(317):185-7
references.pmid: 7671475
references.citation: J Arthroplasty. 2002 Jan;17(1):108-10
references.pmid: 11805935
references.citation: Orthopedics. 2003 Aug;26(8 Suppl):s859-63
references.pmid: 12934741
references.citation: J Bone Joint Surg Br. 2008 Jun;90(6):738-44
references.pmid: 18539666
references.citation: Clin Orthop Relat Res. 2006 Oct;451:101-6
references.pmid: 16760806
references.citation: Am J Orthop (Belle Mead NJ). 2007 Sep;36(9 Suppl):6-7
references.pmid: 17948160
references.citation: J Arthroplasty. 2003 Oct;18(7 Suppl 1):2-8
references.pmid: 14560403
references.citation: Ann Rheum Dis. 1997 Nov;56(11):634-6
references.pmid: 9462163
references.citation: J Bone Joint Surg Am. 2006 May;88(5):959-63
references.pmid: 16651569
references.citation: J Bone Joint Surg Br. 1998 Sep;80(5):909-11
references.pmid: 9768908
references.citation: J Knee Surg. 2006 Apr;19(2):112-6
references.pmid: 16642887
references.citation: Clin Orthop Relat Res. 2004 Nov;(428):125-30
references.pmid: 15534532
references.citation: Arthritis Rheum. 2000 Sep;43(9):1905-15
references.pmid: 11014340
references.citation: Clin Orthop Relat Res. 1984 Apr;(184):118-20
references.pmid: 6705332