title: Splenic rupture in a newborn with severe hemophilia--case report and review.
abstract: Life-threatening splenic rupture is rare in neonates with severe hemophilia. There are only 3 cases of splenic rupture in neonates with hemophilia reported in the literature. We present the case of an infant, born to a hemophilia A carrier mother. The infant was asymptomatic until discharge at 48 hours of age, but presented on the third day of life with shock, abdominal distension, and severe anemia. Computed tomography of the abdomen confirmed the diagnosis of splenic rupture with hemoperitoneum. The infant recovered after extensive supportive care surgery and factor replacement.
authors.affiliation: Department of Pediatrics, The Brooklyn Hospital Center, Brooklyn, NY 11201, USA.
authors.forename: Supatida
authors.initials: S
authors.lastname: Tengsupakul
authors.forename: Aziza
authors.initials: A
authors.lastname: Sedrak
authors.forename: Jennifer
authors.initials: J
authors.lastname: Freed
authors.forename: Lynda
authors.initials: L
authors.lastname: Martinez-Carde
authors.forename: Fernando
authors.initials: F
authors.lastname: Fireman
authors.forename: Louisdon
authors.initials: L
authors.lastname: Pierre
authors.forename: Swayam
authors.initials: S
authors.lastname: Sadanandan
mesh_terms: D000328:Adult; D005169:Factor VIII / Q000627:therapeutic use; D005260:Female; D006467:Hemophilia A / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D013161:Splenic Rupture / Q000000981:diagnostic imaging / Q000209:etiology*; D014057:Tomography, X-Ray Computed
chemical_list: C078147:F8 protein, human; D005169:Factor VIII