Antidepressant-like profile and MAO-A inhibitory activity of 4-propyl-2H-benzo[h]-chromen-2-one.
OBJECTIVE
To evaluate the central nervous pharmacological profile of 4-propyl-2H-benzo[h]-chromen-2-one (FCS-304) in ICR mice and its monoamine oxidase inhibitor activity.


METHODS
FCS-304 was evaluated in screening test of central nervous system in ICR mice and against MAO activity.


RESULTS
FCS-304 (25-200mg/Kg, p.o.) significantly reduced immobility time during the forced swimming test (FST) and tail suspension test (TST), but did not show effects in the rota-rod tests, maximal electroshock seizures (MES), pentylenetetrazole seizures, light-dark box, barbiturate sleeping time and cold plate tests. Furthermore, FCS-304 inhibited monoamine oxidase A (MAO-A) with IC50: 2.28+/-0.15microM, but not MAO-B.


CONCLUSIONS
These results suggest that FCS-304 could elicit antidepressant effects related to MAO-A inhibitory activity.
Vergel
Nadezdha E
NE
Pharmacy Department, School of Sciences, National University of Colombia, Colombia.
López
José L
JL
Orallo
Francisco
F
Viña
Dolores
D
Buitrago
Diana M
DM
del Olmo
Esther
E
Mico
Juan A
JA
Guerrero
Mario F
MF
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D002867:Chromones / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D012640:Seizures / Q000188:drug therapy; D012890:Sleep / Q000187:drug effects
C549557:4-propyl-2H-benzo(h)chromen-2-one; D000928:Antidepressive Agents; D002867:Chromones; D008996:Monoamine Oxidase Inhibitors