[Dual-role regulations of canonical Wnt/beta-catenin signaling pathway].
In recent years, Wnt/beta-catenin signaling has been identified as a key player in embryogenesis and human diseases. Canonical Wnt signaling pathway is controlled by a variety of classic molecules like Wnt, beta-catenin, Axin, APC, GSK-3beta and CK1, which interact and coordinate to regulate the expressions of cell signaling molecules. The latest evidences suggest that some components of the Wnt/beta-catenin signaling, like APC, GSK-3beta, CK1, Dkk2 and WISE, play dual roles different from what they have been thought previously. Here we reviewed some recent discoveries on the canonical Wnt/beta-catenin signaling pathway to provide some new ideas and principles for signaling transduction studies.
Liu
Yang
Y
06 Class of Stomatology, Department of Biochemistry and Molecular Biology, Peking University School of Basic Medical Science, Beijing 100191, China.
Zhang
Chen-guang
CG
Zhou
Chun-yan
CY
D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism / Q000502:physiology; D025601:Adenomatous Polyposis Coli Protein / Q000378:metabolism / Q000502:physiology; D000818:Animals; D060466:Axin Protein; D005786:Gene Expression Regulation; D006801:Humans; D012097:Repressor Proteins / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D051153:Wnt Proteins / Q000378:metabolism / Q000502:physiology*; D051176:beta Catenin / Q000378:metabolism / Q000502:physiology*
D048868:Adaptor Proteins, Signal Transducing; D025601:Adenomatous Polyposis Coli Protein; D060466:Axin Protein; D012097:Repressor Proteins; D051153:Wnt Proteins; D051176:beta Catenin