title: Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis.
abstract: Spermatogenesis is a highly regulated process of germ cell proliferation and differentiation, starting from spermatogonia to spermatocytes and giving rise to spermatids, the future spermatozoa. In addition to endocrine regulation, testicular cell-cell interactions are essential for spermatogenesis. This precise control is mediated through paracrine/autocrine pathways, direct intercellular contacts and through intercellular communication channels, consisting of gap junctions and their constitutive proteins, the connexins. Gap junctions are localized between adjacent Leydig cells, between Sertoli cells and between Sertoli cells and specific germ cells. This review focuses on the distribution of connexins within the seminiferous epithelium, their participation in gap junction channel formation, the control of their expression and the physiological relevance of these junctions in both the Sertoli-Sertoli cell functional synchronization and the Sertoli-germ cell dialogue. In this review, we also discuss the potential implication of disrupted connexin in testis cancer, since impaired expression of connexin has been described as a typical feature of tumoral proliferation.
authors.affiliation: INSERM U 895, Team 5 Physiopathology of Germ Cell Control: Genomic and Non-genomic Mechanisms, Bâtiment Universitaire ARCHIMED, C3M, 151 route Saint-Antoine de Ginestière, BP 2 3194, 06204 Nice Cedex 3, France.
authors.forename: Georges
authors.initials: G
authors.lastname: Pointis
authors.forename: Jérome
authors.initials: J
authors.lastname: Gilleron
authors.forename: Diane
authors.initials: D
authors.lastname: Carette
authors.forename: Dominique
authors.initials: D
authors.lastname: Segretain
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000502:physiology; D017630:Connexins / Q000235:genetics / Q000502:physiology*; D017629:Gap Junctions / Q000502:physiology*; D006801:Humans; D008297:Male; D012670:Seminiferous Epithelium / Q000166:cytology / Q000502:physiology; D012708:Sertoli Cells / Q000166:cytology / Q000502:physiology; D013091:Spermatogenesis / Q000502:physiology*; D013094:Spermatozoa / Q000502:physiology
chemical_list: D017630:Connexins
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