title: Antimicrobial resistance and serotype distribution of Streptococcus pneumoniae strains causing childhood infection in Burkina Faso.
abstract: In Burkina Faso, a Western African country, reports on pneumococci carriage, resistance patterns and serotypes are inconsistent. The present study was conducted in order to evaluate these parameters. Thus 860 nasopharyngeal swabs were collected from children attending vaccination centers for pneumococci isolation, identification and serotype determination. The susceptibility to 16 antibiotics was assayed as recommended by the National Committee for Clinical Laboratory Standard (NCCLS). The results revealed that the majority of children were of 2 to 24 months age and 73.4% of children were well vaccinated. A carriage rate of 50.6% was recoded among the children. The main serotypes were: 6 (22.22%); 23 (16.67%); 7 and 9 (3.70%); 4, 11, 14, 15, 20 and 24 (1.85%). Serotypesl9, 23, 6, 7 and 18 were linked to penicillin resistance. Globally, high resistance rates to: amikacin, tetracyclin, pefloxacin, cotrimoxazol and penicillins (resistance rates greater than 25%) were recorded; however the following antibiotics remained active on the strains: rifampicin, ceftriaxone, erythromycin, spectinomycin, chloramphenicol, vancomycin, lincomycin and ciprofloxacin.
authors.affiliation: Unité de Formation et de Recherche en Sciences de la Vie et de la Terre (UFR/SVT), Université de Ouagadougou, 03 BP 7021, Ouagadougou 03, Burkina Faso.
authors.forename: Leonard C
authors.initials: LC
authors.lastname: Bere
authors.forename: Jacques
authors.initials: J
authors.lastname: Simpore
authors.forename: Simplice D
authors.initials: SD
authors.lastname: Karou
authors.forename: Boukaré
authors.initials: B
authors.lastname: Zeba
authors.forename: Augustin P
authors.initials: AP
authors.lastname: Bere
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Bannerman
authors.forename: Jacques
authors.initials: J
authors.lastname: Bille
authors.forename: Mireille
authors.initials: M
authors.lastname: Dosso
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002050:Burkina Faso / Q000453:epidemiology; D002675:Child, Preschool; D024881:Drug Resistance, Bacterial; D006801:Humans; D007223:Infant; D011008:Pneumococcal Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects / Q000472:pathogenicity
chemical_list: D000900:Anti-Bacterial Agents