Synthesis and antitumor activity of novel 2',3'-diethanethio-2',3',5'-trideoxy-5'-triazolonucleoside analogues.
A series of novel 2',3'-diethanethio-2',3',5'-trideoxy-5'-triazoloribonucleosides was synthesized in excellent yields and their antitumor activity was evaluated. These nucleoside analogues with aromatic substituted triazole rings showed significantly improved activity towards a broad range of tumor cell lines and those without arene substitutes were inactive.
Yu
Jin-Lan
JL
Department of Applied Chemistry and Pharmacy, Beijing Institute of Technology, Nandajie 5, Beijing 100081, P.R. China.
Wu
Qin-Pei
QP
Zhang
Qing-Shan
QS
Xi
Xiao-Dong
XD
Liu
Ning-Ning
NN
Li
Yun-Zheng
YZ
Liu
Yan-Hong
YH
Yin
Hong-Quan
HQ
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D006801:Humans; D020128:Inhibitory Concentration 50; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
D000970:Antineoplastic Agents; D009705:Nucleosides