title: Uncovering the mechanisms of shrimp innate immune response by RNA interference.
abstract: Because of the importance of shrimp in world aquaculture, there is much interest in understanding their immune system in order to improve their resistance to pathogenic microorganisms. An effective tool in studying genes involved in the immune response in shrimp is RNA interference (RNAi). RNAi, first recognized as an antiviral response against RNA viruses, is a cellular mechanism that is triggered by double-stranded RNAs and results in the degradation of homologous genes. In this review, we describe the current studies of genes in shrimp that employed RNAi technology to elucidate or confirm their functions. We also review the potential of RNAi to elicit antiviral response in shrimp.
authors.affiliation: Laboratory of Genome Science, Graduate School of Marine Science and Technology, Tokyo University of Marine Science and Technology, Konan 4-5-7, Minato, Tokyo 108-8477, Japan. hirono@kaiyodai.ac.jp
authors.forename: Ikuo
authors.initials: I
authors.lastname: Hirono
authors.forename: Fernand F
authors.initials: FF
authors.lastname: Fagutao
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Kondo
authors.forename: Takashi
authors.initials: T
authors.lastname: Aoki
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000276:immunology*; D017756:Aquaculture; D001777:Blood Coagulation / Q000276:immunology; D006458:Hemolymph / Q000276:immunology*; D007113:Immunity, Innate / Q000235:genetics / Q000276:immunology*; D014442:Monophenol Monooxygenase / Q000378:metabolism; D033561:Penaeidae / Q000276:immunology*; D034622:RNA Interference / Q000276:immunology*; D013045:Species Specificity
chemical_list: D023181:Antimicrobial Cationic Peptides; D014442:Monophenol Monooxygenase
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