title: Serum PCB concentrations and cochlear function in 12-year-old children.
abstract: Experimental evidence from animals indicates that exposure to polychlorinated biphenyls (PCBs) causes deterioration of the outer hair cells (OHCs) of the cochlea. To test this hypothesis in humans, we measured serum PCB concentrations in 574 12-year-old children residing in three districts in the Slovak Republic using high-resolution gas chromatography with microelectron capture detection. As a marker of cochlear status, we measured transient evoked (TE) and distortion product (DP) otoacoustic emissions (OAEs), and assessed the cross-sectional association between serum PCBs and OAEs. Median total PCB concentrations were 352.8, 150.5, and 134.9 ng/g lipid in Michalovce, Svidnik, and Bratislava, respectively. In multivariate regression models where otoacoustic measures were modeled as a function of log (base 10) PCB concentrations with adjustment for gender, age, and site of examination, dioxin-like PCBs, nondioxin-like PCBs and a PCB grouping targeting upregulation of hepatic uridine 5'-diphospho-glucuronosyltransferase were significantly associated with lower TEOAE powers at 1000 and 1500 Hz. At 1500 Hz, we observed a strong association with sum of PCBs and DL-PCBs, in the left ear only. The DPOAEs at 1000 Hz were associated with all four PCB groupings. The results of this study show that PCBs may affect the OHCs of the cochlea, a result consistent with findings from animal studies published to date.
authors.affiliation: Slovak Medical University, Limbova 12, 83303 Bratislava, Slovakia. tomas.trnovec@szu.sk
authors.forename: Tomás
authors.initials: T
authors.lastname: Trnovec
authors.forename: Eva
authors.initials: E
authors.lastname: Sovcíková
authors.forename: Gabriela
authors.initials: G
authors.lastname: Pavlovcinová
authors.forename: Janka
authors.initials: J
authors.lastname: Jakubíková
authors.forename: Todd A
authors.initials: TA
authors.lastname: Jusko
authors.forename: Milan
authors.initials: M
authors.lastname: Husták
authors.forename: Dana
authors.initials: D
authors.lastname: Jurecková
authors.forename: L'ubica
authors.initials: L
authors.lastname: Palkovicová
authors.forename: Anton
authors.initials: A
authors.lastname: Kocan
authors.forename: Beata
authors.initials: B
authors.lastname: Drobná
authors.forename: Kinga
authors.initials: K
authors.lastname: Lancz
authors.forename: Sona
authors.initials: S
authors.lastname: Wimmerová
mesh_terms: D000158:Acoustic Impedance Tests; D002138:Calibration; D002648:Child; D003051:Cochlea / Q000187:drug effects / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005260:Female; D006801:Humans; D011078:Polychlorinated Biphenyls / Q000097:blood* / Q000633:toxicity; D012015:Reference Standards
chemical_list: D011078:Polychlorinated Biphenyls
references.citation: Exp Clin Endocrinol. 1994;102(5):394-8
references.pmid: 7867703
references.citation: Neurotoxicol Teratol. 1996 May-Jun;18(3):217-27; discussion 229-76
references.pmid: 8725628
references.citation: Audiology. 1997 Mar-Apr;36(2):61-71
references.pmid: 9099404
references.citation: Proc Natl Acad Sci U S A. 2007 May 1;104(18):7646-51
references.pmid: 17460041
references.citation: Toxicol Sci. 2006 Oct;93(2):223-41
references.pmid: 16829543
references.citation: Environ Health Perspect. 1998 Feb;106 Suppl 1:171-89
references.pmid: 9539012
references.citation: Toxicol Sci. 2000 Sep;57(1):131-40
references.pmid: 10966519
references.citation: Eur J Clin Nutr. 1994 Jan;48(1):54-9
references.pmid: 8200329
references.citation: Hear Res. 2002 Apr;166(1-2):136-42
references.pmid: 12062765
references.citation: Hear Res. 2006 Sep;219(1-2):101-9
references.pmid: 16889917
references.citation: Environ Health Perspect. 2007 Oct;115(10):1490-6
references.pmid: 17938741
references.citation: Crit Rev Toxicol. 2006 Oct;36(9):663-94
references.pmid: 17050081
references.citation: Neurotoxicol Teratol. 2001 Jul-Aug;23(4):305-17
references.pmid: 11485834
references.citation: Toxicol Appl Pharmacol. 2009 Jun 1;237(2):168-77
references.pmid: 19289137
references.citation: Neurobiol Aging. 2004 Aug;25(7):945-54
references.pmid: 15212848
references.citation: J Acoust Soc Am. 2008 Mar;123(3):1504-12
references.pmid: 18345839
references.citation: J Am Acad Audiol. 2002 Sep;13(8):403-6
references.pmid: 12371657
references.citation: J Otolaryngol. 2006 Apr;35(2):133-8
references.pmid: 16527033
references.citation: Environ Health Perspect. 2009 Mar;117(3):426-35
references.pmid: 19337518
references.citation: Scand J Work Environ Health. 2000 Jun;26(3):207-12
references.pmid: 10901112
references.citation: Lancet. 2006 Dec 16;368(9553):2167-78
references.pmid: 17174709
references.citation: Fundam Appl Toxicol. 1996 Sep;33(1):120-8
references.pmid: 8812251
references.citation: Int J Audiol. 2002 Apr;41(3):162-9
references.pmid: 12033634
references.citation: Otol Neurotol. 2007 Jun;28(4):434-7
references.pmid: 17435523
references.citation: Crit Rev Toxicol. 2005 Oct-Nov;35(8-9):757-69
references.pmid: 16417043
references.citation: Toxicol Lett. 1998 Dec 28;102-103:631-5
references.pmid: 10022326
references.citation: Hear Res. 2000 Jun;144(1-2):196-204
references.pmid: 10831878
references.citation: Toxicol Sci. 2002 Aug;68(2):458-64
references.pmid: 12151642
references.citation: Environ Health Perspect. 2003 Mar;111(3):357-576
references.pmid: 12611666
references.citation: Eur J Clin Nutr. 2001 Sep;55(9):763-8
references.pmid: 11528490
references.citation: Chemosphere. 2006 Oct;65(3):410-8
references.pmid: 16530805
references.citation: Neuroscience. 2006;137(1):275-86
references.pmid: 16289350
references.citation: Scand Audiol. 2000;29(2):103-10
references.pmid: 10888347
references.citation: Arch Otolaryngol. 1970 Oct;92(4):311-24
references.pmid: 5455571
references.citation: J Am Acad Audiol. 2001 Nov-Dec;12(10):506-13
references.pmid: 11791937
references.citation: Toxicol Sci. 2006 Feb;89(2):415-22
references.pmid: 16317017
references.citation: Environ Toxicol Pharmacol. 2008 Mar;25(2):183-7
references.pmid: 21783857
references.citation: J Acoust Soc Am. 2009 Jan;125(1):239-46
references.pmid: 19173411
references.citation: Neurotoxicol Teratol. 2004 Sep-Oct;26(5):629-37
references.pmid: 15315812
references.citation: Br Med Bull. 2002;63:223-41
references.pmid: 12324396
references.citation: Clin Chim Acta. 1989 Oct 16;184(3):219-26
references.pmid: 2611996
references.citation: Chemosphere. 1994 Nov-Dec;29(9-11):2315-25
references.pmid: 7850380
references.citation: Eur J Endocrinol. 1997 Feb;136(2):180-7
references.pmid: 9116913
references.citation: Acta Otolaryngol. 1991;111(5):861-6
references.pmid: 1759571
references.citation: Chem Res Toxicol. 2006 Jan;19(1):92-101
references.pmid: 16411661
references.citation: Toxicol Appl Pharmacol. 1995 Nov;135(1):77-88
references.pmid: 7482542
references.citation: Environ Health Perspect. 1997 Jan;105(1):13-4
references.pmid: 9074863
references.citation: ORL J Otorhinolaryngol Relat Spec. 2006;68(6):334-9
references.pmid: 17065826
references.citation: J Chromatogr A. 2005 Aug 19;1084(1-2):33-8
references.pmid: 16114233
references.citation: Audiology. 1983;22(2):199-205
references.pmid: 6847535