[Disorder of membrane protein spectrum of erythrocytes in type 1 diabetes mellitus].
The research has shown substantial changes in the percentage correlation between plasmatic membrane proteins and erythrocyte cytoskeleton (alpha-spectrin, beta-spectrin, ankyrin, band 4.1) under type 1 diabetes mellitus. It has also established the difference in the content of erythrocyte membrane glycoproteins, i.e. band 3 proteins and glycophorine A, in healthy donors and patients with diabetes. Thus the content of glycophorine A decreased by 27%, while the content of band 3 protein increased by 23%. Under the pathology, changes in the structure of carbohydrate determinants of erythrocytes membrane glycoproteins were revealed by means of the lectin blot analysis. Type 1 diabetes mellitus is accompanied by an increase in the number of glycoproteins with mannose-containing carbohydrate determinants complementary to Con A and LCA, on the one hand, and a decrease in the number of glycoproteins with sialo- and galactose-containing oligosaccharides complementary to WGA and RCA lectins, on the other hand, on the erythrocyte membrane surface.
Sybirna
N O
NO
Buslyk
T V
TV
D016022:Case-Control Studies; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000378:metabolism*; D003599:Cytoskeleton / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000378:metabolism; D004591:Electrophoresis, Polyacrylamide Gel; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D011487:Protein Conformation
D003598:Cytoskeletal Proteins; D006023:Glycoproteins; D008565:Membrane Proteins