A diet for dopaminergic neurons?
Parkinson's disease (PD) is the second most common neurodegenerative disease, which unfortunately is still fatal. Since the discovery of dopamine (DA) neuronal cell loss within the substantia nigra in PD, the past decades have seen the understanding of the pathophysiological mechanisms underlying the degenerative process advance at a very impressive rate. Nevertheless, there is at present no cure for PD. Although there are no proven therapies for prevention, a large body of evidence from animal studies has highlighted the paramount role of dietary factors in counteracting DA degeneration. Consistently, associations between the risk of developing PD and the intake of nutrients, individual foods, and dietary patterns have been recently shown. Therefore, promoting healthy lifestyle choices such as a Mediterranean diet might be the key to reducing the risk of PD.
Di Giovanni
Giuseppe
G
Dipartimento di Medicina Sperimentale, Sezione di Fisiologia Umana G. Pagano, Università degli Studi di Palermo, Corso Tuköry 129, 90134 Palermo, Italy. g.digiovanni@unipa.it
D000818:Animals; D004032:Diet; D004195:Disease Models, Animal; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D009474:Neurons / Q000502:physiology*; D009747:Nutritional Physiological Phenomena / Q000502:physiology; D010300:Parkinson Disease / Q000178:diet therapy / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control*
D004298:Dopamine