Uncovering molecular biomarkers that correlate cognitive decline with the changes of hippocampus' gene expression profiles in Alzheimer's disease.
BACKGROUND
Alzheimer's disease (AD) is characterized by a neurodegenerative progression that alters cognition. On a phenotypical level, cognition is evaluated by means of the MiniMental State Examination (MMSE) and the post-mortem examination of Neurofibrillary Tangle count (NFT) helps to confirm an AD diagnostic. The MMSE evaluates different aspects of cognition including orientation, short-term memory (retention and recall), attention and language. As there is a normal cognitive decline with aging, and death is the final state on which NFT can be counted, the identification of brain gene expression biomarkers from these phenotypical measures has been elusive.


RESULTS
We have reanalysed a microarray dataset contributed in 2004 by Blalock et al. of 31 samples corresponding to hippocampus gene expression from 22 AD subjects of varying degree of severity and 9 controls. Instead of only relying on correlations of gene expression with the associated MMSE and NFT measures, and by using modern bioinformatics methods based on information theory and combinatorial optimization, we uncovered a 1,372-probe gene expression signature that presents a high-consensus with established markers of progression in AD. The signature reveals alterations in calcium, insulin, phosphatidylinositol and wnt-signalling. Among the most correlated gene probes with AD severity we found those linked to synaptic function, neurofilament bundle assembly and neuronal plasticity.


CONCLUSIONS
A transcription factors analysis of 1,372-probe signature reveals significant associations with the EGR/KROX family of proteins, MAZ, and E2F1. The gene homologous of EGR1, zif268, Egr-1 or Zenk, together with other members of the EGR family, are consolidating a key role in the neuronal plasticity in the brain. These results indicate a degree of commonality between putative genes involved in AD and prion-induced neurodegenerative processes that warrants further investigation.
Gómez Ravetti
Martín
M
Centre for Bioinformatics, Biomarker Discovery and Information-Based Medicine, The University of Newcastle, Callaghan, New South Wales, Australia.
Rosso
Osvaldo A
OA
Berretta
Regina
R
Moscato
Pablo
P
D000544:Alzheimer Disease / Q000175:diagnosis* / Q000235:genetics; D015415:Biomarkers / Q000032:analysis*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000235:genetics; D019295:Computational Biology / Q000379:methods; D020869:Gene Expression Profiling; D006624:Hippocampus / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D009473:Neuronal Plasticity; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D014157:Transcription Factors
D015415:Biomarkers; D014157:Transcription Factors
Biochim Biophys Acta. 1994 Nov 29;1227(3):183-7
7986826
J Alzheimers Dis. 2005 Nov;8(2):139-45; discussion 209-15
16308482
Neurobiol Aging. 1997 Jul-Aug;18(4 Suppl):S99-105
9330997
J Neurochem. 2006 Feb;96(4):924-33
16412100
J Neurosci. 1998 Nov 15;18(22):9269-81
9801366
Diabetes. 2005 Dec;54(12):3343-8
16306348
Hum Mol Genet. 2006 Jan 15;15(2):337-46
16368712
J Neurosci. 2004 Sep 29;24(39):8454-8
15456818
J Comp Neurol. 1998 Apr 20;393(4):426-38
9550149
J Neurosci. 2006 May 3;26(18):4956-60
16672671
J Neurosci. 2008 Dec 10;28(50):13640-8
19074037
Behav Brain Res. 2009 Dec 14;205(1):265-71
19573562
BMC Mol Biol. 2007 Dec 03;8:111
18053171
Neurochem Int. 2002 Oct;41(4):271-7
12106778
Hum Genet. 2006 Mar;119(1-2):169-78
16395595
Nature. 2008 Oct 30;455(7217):1255-8
18923394
Mol Cell Neurosci. 2009 Feb;40(2):280-92
19063970
Cell Mol Neurobiol. 2002 Feb;22(1):13-24
12064514
Neurosci Lett. 2007 May 23;419(1):15-7
17482359
Glia. 1994 Dec;12(4):309-18
7890333
J Neurosci Res. 2005 Jun 15;80(6):741-50
15742362
Neurosci Behav Physiol. 2007 Jul;37(6):559-70
17657426
Hum Mol Genet. 2008 Feb 1;17(3):458-65
17989066
Neurosci Biobehav Rev. 2008 Aug;32(6):1161-73
18573532
J Neural Transm Suppl. 2003;(67):149-58
15068247
Hum Mol Genet. 2008 Apr 15;17(8):1156-68
18184693
Brain Res Mol Brain Res. 1991 Jan;9(1-2):1-8
1850065
J Biol Chem. 2004 Feb 27;279(9):8300-15
14668325
Exp Neurol. 2001 Jan;167(1):158-65
11161603
Neurobiol Aging. 1999 May-Jun;20(3):287-95
10588576
J Psychiatry Neurosci. 2009 May;34(3):181-6
19448847
J Physiol Paris. 2000 May-Aug;94(3-4):193-8
11087996
J Neurochem. 2002 Jun;81(5):903-10
12065602
Brain Nerve. 2008 Feb;60(2):157-70
18306664
Acta Neuropathol. 2004 Sep;108(3):213-23
15170578
J Biol Chem. 2009 Jan 9;284(2):1291-301
18990686
Drug News Perspect. 2006 Oct;19(8):453-60
17160145
J Psychiatr Res. 1975 Nov;12(3):189-98
1202204
Brain Res. 2009 Mar 3;1258:1-11
19150438
Biochem Biophys Res Commun. 2009 Jul 31;385(3):341-5
19463786
Biochim Biophys Acta. 2009 Jul;1793(7):1250-8
19345705
Cancer Res. 2004 Jun 1;64(11):3949-57
15173007
Brain Res Brain Res Rev. 2000 Aug;33(1):1-12
10967351
J Biol Chem. 2002 Jan 18;277(3):2176-85
11707456
J Neurochem. 2002 May;81(3):407-13
12065649
Brain Res. 2007 Oct 12;1174:7-17
17850769
Neurosci Lett. 1993 Nov 12;162(1-2):179-82
8121624
Biochem Biophys Res Commun. 2006 Jul 7;345(3):1149-54
16714002
Neurosci Behav Physiol. 2007 Jul;37(6):607-12
17657432
Neurology. 2007 Oct 16;69(16):1569-79
17761554
Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1989-94
17261798
Neurochem Res. 2000 Jan;25(1):107-20
10685610
PLoS One. 2009;4(2):e4496
19221600
Eur J Neurosci. 1996 Jan;8(1):162-8
8713460
J Alzheimers Dis. 2008 Apr;13(3):295-302
18430997
Cell. 2008 Jan 11;132(1):137-48
18191227
J Huazhong Univ Sci Technolog Med Sci. 2002;22(3):250-2
12658818
Physiol Behav. 2007 Sep 10;92(1-2):93-7
17568632
Braz J Med Biol Res. 1997 May;30(5):599-604
9283626
Hippocampus. 2004;14(3):337-44
15132433
Biochem Biophys Res Commun. 2001 Mar 30;282(2):416-20
11401474
Cerebellum. 2009 Mar;8(1):64-9
19002745
Biochim Biophys Acta. 2009 Feb;1793(2):264-72
18930083
J Alzheimers Dis. 2003 Aug;5(4):329-35
14624029
J Neurosci Res. 2009 May 15;87(7):1532-46
19125404
Nat Med. 2007 Nov;13(11):1359-62
17934472
Brain Res. 2006 May 17;1089(1):126-34
16631140
Horm Metab Res. 2009 Feb;41(2):159-63
19214925
Arch Physiol Biochem. 2006 Oct-Dec;112(4-5):274-84
17178602
J Neurochem. 2004 Aug;90(4):829-38
15287888
Biochem Biophys Res Commun. 2009 Feb 6;379(2):406-10
19109927
Neurochem Int. 2008 Mar-Apr;52(4-5):621-33
18035450
Biochem Biophys Res Commun. 2001 Dec 21;289(5):924-8
11741278
J Cell Sci. 2000 Jun;113 ( Pt 11):1851-6
10806096
Endocrinology. 2004 Jun;145(6):3023-31
14976144
J Neuroinflammation. 2007 Dec 20;4:31
18093340
Exp Anim. 2007 Apr;56(2):93-101
17460354
PLoS Genet. 2009 Jun;5(6):e1000536
19557195
Neurobiol Dis. 2003 Dec;14(3):458-69
14678762
J Biol Chem. 2008 Jul 25;283(30):20628-34
18524768
FASEB J. 2005 Nov;19(13):1905-7
16162853
J Neurosci Res. 2007 Jun;85(8):1744-51
17455309
J Biol Chem. 1994 Apr 15;269(15):10971-4
8157621
J Biol Chem. 2003 Apr 18;278(16):14066-73
12556519
Brain Res. 1999 Jul 3;833(2):297-301
10375708
J Hypertens. 2005 Jul;23(7):1285-309
15942449
Neuroscience. 2006;138(3):749-56
16338086
Neurosci Lett. 2003 Apr 10;340(2):107-10
12668248
J Neurol Sci. 1994 Feb;121(2):132-8
8158204
Acta Neuropathol. 2005 Jun;109(6):598-602
15895198
FEBS Lett. 2005 Mar 28;579(9):1995-2000
15792809
Biochem Biophys Res Commun. 1999 May 10;258(2):385-9
10329396
Psychoneuroendocrinology. 2009 Nov;34(10):1495-505
19505767
Neurobiol Dis. 2008 Jun;30(3):353-364
18387811
Ann Neurol. 2000 May;47(5):688
10805351
Ann Neurol. 2003 Jan;53(1):123-7
12509857
Am J Pathol. 2000 Aug;157(2):497-507
10934153
C R Biol. 2008 May;331(5):347-56
18472080
J Cell Sci. 2003 Apr 1;116(Pt 7):1175-86
12615961
J Neurocytol. 2003 Jun-Sep;32(5-8):603-17
15034256
Biol Psychiatry. 2006 Jan 15;59(2):155-61
16125145
Proc Natl Acad Sci U S A. 1993 Aug 15;90(16):7647-51
8356066
Cell Mol Life Sci. 2006 Jun;63(11):1226-35
16568235
Hum Mol Genet. 2007 Apr 1;16(7):837-47
17341491
Brain Res. 2006 Sep 7;1108(1):98-106
16843447
Nature. 2009 May 28;459(7246):569-73
19404257
Acta Neuropathol. 1991;82(4):239-59
1759558
J Neural Transm Suppl. 1994;44:259-68
7897397
Mol Neurodegener. 2006 Aug 18;1:8
16930455
Ann N Y Acad Sci. 1999;893:301-3
10672254
Physiol Behav. 2009 Aug 4;98(1-2):44-52
19389414
Proc Natl Acad Sci U S A. 2004 Aug 17;101(33):12218-23
15302938
J Biol Chem. 2003 May 23;278(21):19220-9
12626503
Life Sci. 1996;59(5-6):499-510
8761338
Cancer Biol Ther. 2007 May;6(5):712-8
17507796
Exp Neurol. 2006 Jul;200(1):209-15
16545374
Science. 2006 Apr 28;312(5773):592-6
16543415
Curr Med Chem. 2007;14(16):1729-38
17627510
Brain Res. 2002 Jun 14;940(1-2):49-54
12020874
J Biol Chem. 2004 Dec 10;279(50):52124-31
15466855
J Neurosci. 2007 Nov 21;27(47):12945-56
18032668
Semin Cell Dev Biol. 2009 Apr;20(2):191-200
19041409
Biochemistry. 2000 Mar 28;39(12):3206-15
10727212
Neuropharmacology. 2004 Sep;47(4):475-84
15380367
Pflugers Arch. 2005 Oct;451(1):105-15
15924238
J Biol Chem. 2006 Nov 17;281(46):35021-9
16982607
Biochem J. 2003 May 15;372(Pt 1):183-91
12570872
Arch Neurol. 1999 Jun;56(6):713-8
10369312
J Neural Transm (Vienna). 2002 Jul;109(7-8):991-1002
12111436
FEBS Lett. 2001 Oct 19;507(1):81-7
11682063
J Hum Genet. 2009 Feb;54(2):94-7
19158810
J Biol Chem. 1999 Oct 8;274(41):29510-8
10506216
J Cell Biol. 2001 Feb 19;152(4):F17-20
11266476
J Neurosci. 2008 May 7;28(19):5105-14
18463264
Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14434-9
16186507
PLoS One. 2008 Apr 30;3(4):e2084
18446215
Nucleic Acids Res. 2007 Jul;35(Web Server issue):W105-14
17545194
Mech Ageing Dev. 2001 Dec;123(1):11-20
11640947
J Biol Chem. 2004 Jul 9;279(28):29639-46
15126508
Mol Cell Neurosci. 2004 May;26(1):182-90
15121189
J Histochem Cytochem. 2007 Mar;55(3):301-11
17164411
PLoS One. 2009;4(1):e4328
19180187
Nucleic Acids Res. 2005 Oct 12;33(18):5715-27
16221973
Exp Cell Res. 2003 Sep 10;289(1):95-107
12941608
Amino Acids. 2001;21(3):293-301
11764410
J Neurosci Res. 1996 Apr 01;44(1):12-20
8926625
J Neuroimmunol. 2004 Oct;155(1-2):21-31
15342193
Gerontology. 2000 Jul-Aug;46(4):185-8
10859456
J Neuropathol Exp Neurol. 1998 Mar;57(3):218-25
9600213
Cell Mol Neurobiol. 2009 Mar;29(2):273-86
18925431
EMBO J. 1986 Feb;5(2):269-76
2423324
Brain Pathol. 2008 Oct;18(4):484-96
18371174
J Neurosci. 2006 Aug 30;26(35):9047-56
16943563
Clin Exp Immunol. 1999 Mar;115(3):526-33
10193429
J Neurobiol. 2000 Mar;42(4):460-76
10699983
Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):103-13
19367581
Behav Brain Res. 2005 Jul 1;162(1):108-15
15922071
J Neurosci. 2005 Oct 19;25(42):9694-703
16237174
Exp Neurol. 2005 Jun;193(2):455-68
15869948
J Gerontol. 1994 Mar;49(2):P52-7
8126359
J Biol Chem. 2004 Apr 30;279(18):19051-63
14960569
Schizophr Bull. 2011 Jan;37(1):141-7
19549627
Genome Biol. 2007;8(6):R128
17598886
Hum Mutat. 2002 Jul;20(1):1-14
12112652
Restor Neurol Neurosci. 1998 Jun;12(2-3):167-73
12671312
Dement Geriatr Cogn Disord. 2001 Mar-Apr;12(2):110-6
11173883
Biochemistry. 1994 Aug 16;33(32):9627-36
8068639
Exp Cell Res. 2004 Jul 1;297(1):186-96
15194435
J Biomed Sci. 2008 Mar;15(2):169-81
17960496
Nat Neurosci. 2004 Sep;7(9):1003-9
15332090
Methods Mol Biol. 2008;453:379-92
18712315
Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5585-90
18385378
Biochim Biophys Acta. 2007 Apr;1769(4):244-52
17482685
Lab Invest. 1989 Apr;60(4):513-22
2468822
J Biol Chem. 2005 Jan 14;280(2):1641-51
15528213
Dev Dyn. 2003 Mar;226(3):460-9
12619132
Ann N Y Acad Sci. 2008 Dec;1147:335-47
19076455
Eur J Neurosci. 2008 Jan;27(2):315-25
18215230
Hippocampus. 2008;18(7):692-8
18398851
J Neurochem. 1995 Aug;65(2):717-24
7616228
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2004 Feb;26(1):62-5
15052777
Brain Res Brain Res Rev. 2004 Dec;47(1-3):275-89
15572177
Biopolymers. 1995 Sep;36(3):381-9
7669921
Exp Mol Pathol. 2009 Feb;86(1):18-22
19041304
Biochem Soc Trans. 2003 Aug;31(Pt 4):889-92
12887328
J Clin Endocrinol Metab. 2008 May;93(5):1865-73
18285410
J Neurosci. 2003 Nov 26;23(34):10800-8
14645472
J Biol Chem. 2004 Mar 12;279(11):10389-96
14679199
Mol Chem Neuropathol. 1996 Feb;27(2):195-210
8962603
Genes Dev. 2009 Jul 1;23(13):1571-85
19515974
Mol Cell Neurosci. 2007 May;35(1):76-88
17350282
Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):775-80
18174334
J Biol Chem. 2005 Aug 19;280(33):29612-9
15980432
Cereb Cortex. 2005 Apr;15(4):385-93
15749982
Neurobiol Aging. 2003 Oct;24(6):807-15
12927763
Cerebellum. 2009 Sep;8(3):312-22
19238500
J Biol Chem. 2007 Oct 26;282(43):31504-16
17716970
J Cell Mol Med. 2008 Jun;12(3):914-27
18494933
Prog Neurobiol. 2006 Jul;79(4):205-21
16916571
Neuron. 2007 Jun 7;54(5):755-70
17553424
Neurology. 2007 Jan 30;68(5):387-8
17261688
Brain. 2009 May;132(Pt 5):1161-74
19293237
Neuron. 2003 Nov 13;40(4):695-701
14622575
J Alzheimers Dis. 2005 Apr;7(2):103-17; discussion 173-80
15851848
J Neuropathol Exp Neurol. 2009 Jun;68(6):642-52
19458545
Cytogenet Cell Genet. 2000;89(1-2):11-3
10894927
Gerontologist. 2001 Dec;41(6):716-22
11723339
BMC Neurosci. 2007 May 23;8:35
17521432
Neuroendocrinology. 1995 Aug;62(2):101-10
8584109
Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29;358(1432):805-14
12740127
J Neurosci Methods. 2009 Jul 30;181(2):257-67
19445963
Neurochem Int. 1997 Apr-May;30(4-5):347-74
9106250
Behav Neurosci. 2006 Apr;120(2):353-61
16719699
J Neurosci. 2008 Jan 2;28(1):60-7
18171923
J Neural Transm (Vienna). 1998;105(4-5):415-22
9720971
Mol Psychiatry. 2003 Feb;8(2):195-208
12610652
PLoS Genet. 2009 Jun;5(6):e1000511
19521500
Methods Mol Biol. 2008;453:363-77
18712314
Am J Alzheimers Dis Other Demen. 2007 Aug-Sep;22(4):319-28
17712163
Microsc Res Tech. 2003 Oct 15;62(3):232-9
14506689
Bioinformatics. 2006 Dec 1;22(23):2926-33
17000751
J Pharmacol Exp Ther. 2006 Mar;316(3):1335-45
16326923
Brain Res. 1995 Feb 13;671(2):282-92
7743216
Neurobiol Dis. 2001 Jun;8(3):492-503
11442356
J Biol Chem. 2003 May 16;278(20):18597-605
12637513
Curr Biol. 1999 Nov 18;9(22):R848-50
10574750
Neurology. 2003 Oct 14;61(7):988-90
14557576
Neurobiol Aging. 1991 Jul-Aug;12(4):295-312
1961359
Neurobiol Aging. 1995 May-Jun;16(3):271-8; discussion 278-84
7566337
Development. 2009 Mar;136(5):723-7
19158184
J Biol Chem. 2008 Apr 18;283(16):10513-21
18245083
Mol Cell Neurosci. 2008 Aug;38(4):616-28
18595732
Cell Cycle. 2008 Dec 15;7(24):3819-22
19124971
Brain Res Mol Brain Res. 2002 Aug 15;104(2):127-31
12225865
Neurochem Res. 2008 Aug;33(8):1599-609
18461448
J Biol Chem. 2000 Nov 3;275(44):34266-71
10954722
Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6735-40
16618925
Biochemistry. 2008 Feb 26;47(8):2244-51
18237193
BMC Genomics. 2008 Nov 18;9:546
19017407
Neurochem Int. 2005 Jan;46(2):159-68
15627516
Prog Neuropsychopharmacol Biol Psychiatry. 1999 Apr;23(3):519-31
10378234
Exp Neurol. 1997 Oct;147(2):316-32
9344557
Muscle Nerve. 2003 Nov;28(5):561-9
14571457
Dev Psychopathol. 2006 Summer;18(3):853-76
17152404
Eur J Pharmacol. 2004 Apr 19;490(1-3):1-4
15094068
Annu Rev Neurosci. 1998;21:479-505
9530504
Behav Brain Res. 2003 Jun 16;142(1-2):17-30
12798262
J Geriatr Psychiatry Neurol. 1994 Jul-Sep;7(3):153-8
7522458
J Biol Chem. 2001 Dec 21;276(51):48458-65
11583995
Biochim Biophys Acta. 2009 Nov;1791(11):1093-101
19615462
Anal Bioanal Chem. 2002 Feb;372(3):412-7
11939525
Nat Neurosci. 2009 Jul;12(7):829-38
19503085
Prion. 2008 Apr-Jun;2(2):51-6
19098445
Am J Pathol. 1999 Mar;154(3):927-36
10079271
Nature. 2003 Aug 7;424(6949):677-81
12904794
Neurobiol Aging. 2005 Aug-Sep;26(8):1145-51
15917097
J Alzheimers Dis. 2007 Jun;11(3):385-97
17851188
J Biol Chem. 2001 Dec 7;276(49):46046-53
11598134
Microbiology (Reading). 2007 Jan;153(Pt 1):196-205
17185548
Stem Cells. 2009 Aug;27(8):1858-68
19544418
Brain. 2009 Apr;132(Pt 4):1078-92
19151372
Curr Alzheimer Res. 2007 Apr;4(2):205-12
17430248
Biochem J. 1998 Feb 15;330 ( Pt 1):513-9
9461550
Neurol Res. 2008 Jul;30(6):613-22
18647502
PLoS One. 2009;4(3):e4936
19295912
Proteomics. 2006 Mar;6(6):1822-32
16470652
Acta Neurol Scand Suppl. 1996;165:18-24
8740985
Acta Neurol Scand. 2009 Aug;120(2):130-3
19154537
Neurobiol Aging. 1997 May-Jun;18(3):281-4
9263192
Exp Cell Res. 2004 Apr 15;295(1):245-57
15051507
J Mol Neurosci. 1999 Apr;12(2):101-9
10527454
Mol Biol Cell. 2009 Mar;20(5):1533-44
19144826
FEBS Lett. 2006 Jul 10;580(16):3973-9
16806196
J Neurosci. 2004 May 26;24(21):4971-7
15163689
J Neural Transm (Vienna). 1998;105(4-5):423-38
9720972
Brain Res Mol Brain Res. 2003 Oct 21;118(1-2):60-71
14559355
Mol Cell Neurosci. 2002 Dec;21(4):584-601
12504592
J Exp Zool. 1998 Jan 1;280(1):91-6
9437855
Biochem Biophys Res Commun. 2009 Apr 10;381(3):383-7
19232519
Brain. 2003 Mar;126(Pt 3):590-7
12566280
Prostate. 2003 Apr 1;55(1):55-64
12640661
J Cell Sci. 2002 Dec 1;115(Pt 23):4695-706
12415013
Neurobiol Dis. 2005 Apr;18(3):638-48
15755689
J Psychiatr Res. 2009 Jan;43(3):282-90
18490030
FASEB J. 2008 Aug;22(8):2970-80
18413858
FEBS J. 2009 Aug;276(15):4276-86
19583771
J Pineal Res. 2004 Apr;36(3):186-91
15009509
J Neurosci. 2006 Aug 9;26(32):8398-408
16899735
Audiol Neurootol. 2001 Nov-Dec;6(6):319-45
11847462
Brain Res Mol Brain Res. 2003 Aug 19;116(1-2):38-49
12941459
Eur J Neurosci. 2003 Oct;18(8):2213-26
14622182
Trends Cell Biol. 2005 Nov;15(11):574-80
16202603
J Neural Transm (Vienna). 2009 Apr;116(4):479-86
19184335
J Neurosci. 2003 Jun 15;23(12):5219-26
12832546
Ann N Y Acad Sci. 1997 Sep 26;826:379-81
9329707
Brain Res. 1997 Sep 26;769(2):385-90
9374211
Neurosci Lett. 2006 May 1;398(1-2):107-12
16434140
Biochem Soc Trans. 2003 Dec;31(Pt 6):1397-9
14641072
Nat Struct Mol Biol. 2005 Apr;12(4):364-71
15768032
Mol Psychiatry. 2006 Jul;11(7):633-48
16702976
Neurosignals. 2003 Sep-Oct;12(4-5):252-64
14673212
Proc Natl Acad Sci U S A. 2006 May 9;103(19):7482-7
16641098
J Neurosci. 2006 Jan 11;26(2):655-61
16407563
J Neurochem. 2009 Mar;108(6):1595-606
19166514
Crit Rev Oncol Hematol. 2008 Jan;65(1):43-53
17644000
J Neurochem. 2003 Jun;85(5):1216-27
12753081
J Neurosci. 2004 Jul 21;24(29):6629-37
15269275
J Neurosci. 2008 Nov 12;28(46):12010-22
19005066
PLoS One. 2008;3(11):e3676
18989376
J Clin Invest. 2007 Apr;117(4):931-43
17380209
Eur J Neurosci. 2001 Jan;13(2):221-9
11168526
J Neurosci. 2005 May 4;25(18):4649-58
15872113
Am J Med Genet B Neuropsychiatr Genet. 2007 Mar 5;144B(2):129-58
17266109
Nat Cell Biol. 2000 Nov;2(11):805-11
11056535
J Biol Chem. 2002 Dec 27;277(52):50497-502
12401793
Neurochem Res. 2009 Jan;34(1):17-22
18465224
Neurosci Lett. 1999 Feb 19;261(3):143-6
10081969
J Biol Chem. 2004 Jul 2;279(27):28706-14
15105421
J Biol Chem. 2009 Jan 23;284(4):2472-81
19008222
Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1971-6
19188609
Curr Opin Neurobiol. 2009 Apr;19(2):231-4
19545994
J Biol Chem. 2001 Dec 21;276(51):48554-61
11606587
J Alzheimers Dis. 2003 Apr;5(2):127-37
12719630
J Neural Transm (Vienna). 2009 Mar;116(3):357-61
19194776
Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Apr;65(4 Pt 1):041905
12005871
BMC Neurosci. 2007 Apr 12;8:25
17428348
In Silico Biol. 2008;8(5-6):545-54
19374137
Nat Neurosci. 2005 May;8(5):664-72
15834420
J Neurosci. 2002 Mar 15;22(6):2185-95
11896158
Brain Res. 2007 Feb 9;1132(1):20-8
17188656
Neurobiol Aging. 1997 Jan-Feb;18(1):37-44
8983031
J Alzheimers Dis. 2009;16(2):301-7
19221419
J Neurosci. 2008 Dec 31;28(53):14511-21
19118186
Brain Res. 2007 Jan 12;1128(1):40-9
17125750
Nat Struct Mol Biol. 2005 Aug;12(8):691-8
16041388
Br J Pharmacol. 2004 Nov;143(5):606-10
15466441
Neurobiol Dis. 1999 Feb;6(1):56-62
10078973
Clin Chem. 2009 May;55(5):1041-3
19264852
Mech Ageing Dev. 2009 Apr;130(4):253-61
19162061
Hum Mol Genet. 2009 Feb 1;18(3):391-404
18996920
Behav Brain Res. 2009 Jul 19;201(1):147-57
19428628
J Alzheimers Dis. 2004 Dec;6(6):623-32; discussion 673-81
15665402
Annu Rev Neurosci. 2003;26:565-97
12730322
Neural Plast. 2008;2008:269097
19190776
Behav Neurosci. 2004 Aug;118(4):845-51
15301610
Acta Neuropathol. 2009 Jul;118(1):53-69
19184068
Curr Opin Genet Dev. 2009 Jun;19(3):266-70
19345090
Gene. 1993 Dec 31;137(2):299-302
8299963
Development. 2009 Mar;136(5):771-9
19176585
J Cell Sci. 2005 Dec 1;118(Pt 23):5647-60
16306227
Am J Hum Genet. 2008 Feb;82(2):477-88
18252227
BMC Neurosci. 2007 Jan 02;8:1
17199885
J Neurochem. 1987 Feb;48(2):455-62
2432180
J Neural Transm (Vienna). 2006 Feb;113(2):219-30
15959850
J Biol Chem. 2002 Dec 6;277(49):47732-40
12359720
Aust N Z J Psychiatry. 2008 Aug;42(8):662-77
18622774
Prog Neurobiol. 2008 Nov;86(3):281-96
18786602
Neuropsychobiology. 2009;59(4):205-12
19521112
Eur J Biochem. 2001 Mar;268(6):1518-27
11248668
J Neurosci. 2005 Mar 9;25(10):2741-52
15758184
J Biol Chem. 2005 Nov 11;280(45):37461-70
16147998
Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4772-7
9114067
Oncogene. 2006 Dec 4;25(57):7545-53
17143299
Eur J Neurosci. 2006 Jun;23(12):3375-84
16820027
Neuroscience. 2006 Feb;137(3):747-59
16298079
FEBS Lett. 1997 Mar 3;404(1):41-4
9074634
Ageing Res Rev. 2009 Apr;8(2):71-82
19101658
J Biol Chem. 2003 Oct 17;278(42):41221-6
12896979
J Comp Neurol. 2007 Jan 20;500(3):477-97
17120287
IDrugs. 2000 Jul;3(7):740-1
16080039
Neuromolecular Med. 2004;5(2):133-46
15075440
J Neurochem. 1992 Apr;58(4):1205-10
1312569
Zhonghua Yi Xue Za Zhi. 2002 Apr 25;82(8):519-22
12133495
Mol Pharmacol. 2007 Apr;71(4):1148-58
17234898
J Cereb Blood Flow Metab. 2003 Sep;23(9):1020-8
12973018
J Neural Transm Suppl. 1997;49:11-21
9266410
Int J Mol Med. 2006 Oct;18(4):729-34
16964429
Proc Natl Acad Sci U S A. 2009 May 5;106(18):7501-6
19416921
Arch Physiol Biochem. 2007 Jun;113(3):131-41
17922309
BMC Med Genet. 2008 Dec 16;9:109
19087248
J Comp Neurol. 2005 Aug 1;488(3):342-51
15952168
Neurobiol Aging. 2001 Nov-Dec;22(6):945-56
11755003
J Neural Transm (Vienna). 2008 Sep;115(9):1355-65
18665322
J Biol Chem. 2009 May 1;284(18):12562-71
19270309
J Neurosci Res. 2008 Nov 15;86(15):3265-74
18627032
Curr Opin Neurol. 2004 Aug;17(4):437-42
15247539
Ann Med. 1989;21(2):113-6
2475147
J Neural Transm Park Dis Dement Sect. 1991;3(1):1-14
1905936
J Cell Mol Med. 2008 Jan-Feb;12(1):241-57
18208556
Hum Mol Genet. 2008 Jun 1;17(11):1569-77
18270208
J Neural Transm (Vienna). 2003 Sep;110(9):1041-50
12938026
Hum Brain Mapp. 2009 Oct;30(10):3406-16
19350564
J Comp Neurol. 2003 Jan 13;455(3):368-77
12483688
J Neurochem. 2004 Nov;91(3):623-33
15485493
Neuropathol Appl Neurobiol. 2004 Dec;30(6):635-50
15541004
J Neurosci. 1995 Oct;15(10):6919-25
7472448
Curr Alzheimer Res. 2004 Nov;1(4):249-54
15975054
Nature. 1993 Jun 24;363(6431):718-22
8515813
Proc Natl Acad Sci U S A. 2007 May 29;104(22):9434-9
17517621
J Neurosci. 2004 Mar 10;24(10):2481-95
15014124
Neurobiol Aging. 2008 Jul;29(7):1011-21
17350733
Am J Hum Genet. 2008 Jan;82(1):199-207
18179900
Biol Psychiatry. 2008 Nov 15;64(10):835-41
18514164
Ann N Y Acad Sci. 1994 May 31;719:248-56
8010597
J Biol Chem. 2006 Feb 17;281(7):4267-73
16332687
Ann N Y Acad Sci. 2000;920:256-8
11193160
J Neurosci. 1994 Sep;14(9):5223-35
8083732
Exp Neurol. 1999 Jan;155(1):31-41
9918702
Int J Cancer. 2008 Aug 1;123(3):561-8
18498136
Nat Neurosci. 2005 Aug;8(8):1051-8
16025111
Am J Pathol. 2000 Sep;157(3):895-904
10980129
Neurosci Lett. 2009 Mar 20;452(3):277-80
19348738
J Biol Chem. 2009 Apr 24;284(17):11285-92
19221179
Hum Mol Genet. 2007 Jan 1;16(1):24-35
17158188
Mol Cell Neurosci. 2009 Sep;42(1):75-80
19520166
Biochem Biophys Res Commun. 2008 Apr 4;368(2):285-91
18230341
Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3881-9
19324851
Biofizika. 2005 Sep-Oct;50(5):803-9
16248154
Hum Mol Genet. 1999 Dec;8(13):2557-66
10556305
J Neurosci Res. 1998 Oct 1;54(1):46-57
9778149
Biochem Soc Trans. 2002 Aug;30(4):464-8
12196116
Int Psychogeriatr. 1998 Mar;10(1):11-23
9629521
Cell Mol Neurobiol. 2009 Jun;29(4):497-501
19137424
Am J Psychiatry. 1984 Nov;141(11):1356-64
6496779
J Neurochem. 2005 Nov;95(3):796-810
16248890
J Neurosci. 1991 Nov;11(11):3325-43
1719159
Ann N Y Acad Sci. 2006 Nov;1086:35-53
17185504
NMR Biomed. 2007 May;20(3):343-51
17451178
Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2150-4
7681585
Neurochem Int. 2009 Jan;54(1):28-36
18984021
J Cell Biochem. 2005 Nov 1;96(4):728-40
16088944
Discov Med. 2006 Jun;6(33):123-7
17234147
PLoS One. 2008;3(11):e3652
18987751
Brain Res. 2009 Jan 16;1249:237-43
19013138
J Neuropathol Exp Neurol. 2001 Sep;60(9):906-16
11556547
Prog Neurobiol. 2004 Nov;74(4):183-211
15556287
Neurochem Int. 2007 Jan;50(1):12-38
16973241
J Neural Transm Suppl. 1998;54:167-74
9850925
Neuroscience. 2008 Dec 10;157(4):833-43
18951956
Am J Pathol. 2003 Mar;162(3):823-35
12598317
Invest Ophthalmol Vis Sci. 2009 Feb;50(2):793-800
18791173
Neuron. 2000 Jan;25(1):191-201
10707983
J Neurophysiol. 2009 Mar;101(3):1179-91
19073796
Trends Neurosci. 2002 Feb;25(2):64-7
11814549
Brain Res. 2006 May 9;1088(1):83-92
16631143
Behav Neurosci. 2006 Apr;120(2):241-8
16719688
FASEB J. 2005 Apr;19(6):583-5
15703272
Curr Alzheimer Res. 2008 Aug;5(4):385-91
18690835
Mol Biol Cell. 2008 Dec;19(12):5226-37
18815274
Exp Neurol. 2001 Sep;171(1):29-45
11520119
Neurology. 2000 Aug 8;55(3):370-6
10932270
J Neurosci Res. 1996 Aug 01;45(3):258-68
8841986
J Biol Chem. 2004 Apr 30;279(18):18911-9
14985338
Neurosignals. 2002 Sep-Oct;11(5):262-9
12566927
Mol Med Today. 2000 Feb;6(2):54-9
10652477
J Neural Transm (Vienna). 2007 Mar;114(3):373-7
17086487
J Neurosci. 2006 Jan 25;26(4):1303-13
16436618
J Neural Transm. 1989;75(3):227-32
2926384
J Cell Commun Signal. 2009 Mar;3(1):79-84
19390991
Proc Natl Acad Sci U S A. 1988 Aug;85(16):6218-21
3137567
Neurosci Lett. 1998 Mar 13;244(2):69-72
9572587
J Cell Biol. 1999 Mar 22;144(6):1349-60
10087275
Neuron. 1994 Oct;13(4):989-1002
7946342
J Biol Chem. 2003 Dec 19;278(51):51100-7
14527950
J Neurochem. 2004 Jan;88(2):434-42
14690531
J Biol Chem. 2008 Apr 25;283(17):11445-52
18305116
Mol Cell Proteomics. 2007 Aug;6(8):1318-30
17470424
J Biol Chem. 1996 Nov 1;271(44):27770-5
8910372
Exp Neurol. 2001 Feb;167(2):205-14
11161609
Curr Alzheimer Res. 2004 Feb;1(1):33-8
15975083
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2001 Oct;23(5):445-9
12905859
J Neural Transm Suppl. 2007;(72):217-33
17982898
J Neurochem. 2007 Feb;100(4):1032-46
17156128
Dement Geriatr Cogn Disord. 1998 Jan-Feb;9(1):13-9
9469259
Methods Enzymol. 2008;446:237-57
18603126
J Clin Invest. 2009 Apr;119(4):679-80; author reply 680-1
19339759
Eur J Neurol. 2007 Apr;14(4):369-72
17388982
Nature. 1993 Aug 5;364(6437):540-4
8393147
J Neurosci. 2006 Jan 25;26(4):1239-46
16436611
PLoS One. 2009;4(4):e5230
19381277
FEBS Lett. 2001 Nov 2;507(3):288-94
11696357
Eur J Neurosci. 2007 Mar;25(5):1287-96
17355253
Clin Chem. 2006 Sep;52(9):1713-21
16858073
J Mol Biol. 1992 Feb 5;223(3):673-82
1542114
Rinsho Shinkeigaku. 2003 Nov;43(11):775-8
15152461
J Comp Neurol. 2004 Aug 2;475(4):551-63
15236236
Neurosignals. 2008;16(4):300-17
18635946
Am J Med Genet B Neuropsychiatr Genet. 2005 Nov 5;139B(1):28-32
16082692
J Neurol. 1987 May;234(4):266-7
2886559
Prog Neurobiol. 2004 Dec;74(6):323-49
15649580
Brain Res Rev. 2007 Dec;56(2):384-402
17920690
J Biol Chem. 2002 Mar 8;277(10):7816-23
11748228
Development. 2004 Nov;131(22):5671-81
15509767
BMC Genet. 2005 Dec 30;6 Suppl 1:S30
16451640
Lab Invest. 1991 Mar;64(3):352-7
1706004
Neurobiol Dis. 2007 Jan;25(1):150-62
17046272
Neuroscience. 2008 Jun 2;153(4):1202-12
18440708
Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):2173-8
14769913
Nucleic Acids Res. 2009 May;37(9):3007-20
19304756
Neurology. 1984 Jul;34(7):939-44
6610841
BMC Med Genet. 2004 Apr 16;5:10
15090072
J Endocrinol Invest. 2002 Jan;25(1):73-83
11883869
Brain Res Mol Brain Res. 2003 Aug 19;116(1-2):147-54
12941470
Nature. 1999 Dec 9;402(6762):615-22
10604467
Mol Cell Biol. 2003 Sep;23(17):6027-36
12917327
Eur J Pharmacol. 2008 Apr 7;583(2-3):215-25
18342852
Mol Cell Neurosci. 2005 May;29(1):56-64
15866046
Eur J Neurosci. 2003 Jan;17(1):149-54
12534978
Biochem Biophys Res Commun. 1997 Jul 18;236(2):239-42
9240416
J Neurosci Res. 2008 Dec;86(16):3684-92
18655199
Nat Neurosci. 2001 Mar;4(3):282-8
11224545
Hum Mol Genet. 2009 Mar 1;18(5):988-96
18945720
J Neurobiol. 2001 Sep 15;48(4):265-77
11500840
Neurobiol Dis. 2001 Oct;8(5):900-9
11592857
Prog Nucleic Acid Res Mol Biol. 1998;61:1-23
9752717
J Biol Chem. 2008 Apr 4;283(14):9359-68
18234671
Toxicol Appl Pharmacol. 2007 Nov 15;225(1):1-27
17904601
J Cell Biol. 1992 Jun;117(5):1085-92
1577867
Psychiatr Genet. 2009 Jun;19(3):113-6
19339916
J Neural Transm (Vienna). 2004 Mar;111(3):367-86
14991460
BMC Mol Biol. 2009 Jun 16;10:57
19531214
Neurobiol Aging. 1993 Nov-Dec;14(6):661-3
8295678
Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2002 Jun;24(3):298-301
12905639
Cell Cycle. 2006 May;5(10):1111-5
16721052
Neuron. 1998 Aug;21(2):359-71
9728917
J Int Med Res. 2005 Nov-Dec;33(6):654-60
16372583
Biochem Biophys Res Commun. 2009 Feb 6;379(2):400-5
19126401
Mol Cell Neurosci. 2004 Jun;26(2):330-41
15207857
Eur J Med Chem. 2009 Jun;44(6):2748-53
18790550
Biochim Biophys Acta. 2009 Apr;1792(4):353-63
19419698
J Cell Physiol. 2003 Jul;196(1):105-12
12767046
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3907-12
19237574
Mol Cell Biol. 2008 Mar;28(5):1515-27
18195042
Biochim Biophys Acta. 2009 May;1792(5):482-96
19026743
Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19318-23
19050078
Exp Neurol. 2009 May;217(1):124-35
19416667
Neurobiol Dis. 2004 Jul;16(2):346-59
15193291
PLoS One. 2008 Sep 03;3(9):e3111
18769539
J Neurosci. 2005 Apr 27;25(17):4442-51
15858070
Hum Mol Genet. 2004 Jan 1;13(1):47-52
14583441
BMC Psychiatry. 2008 Nov 07;8:87
18992145
Bioinformatics. 2003 Nov 1;19(16):2155-7
14594725
Biol Psychiatry. 2009 Mar 15;65(6):535-40
19058791
J Neurol Sci. 2007 Jun 15;257(1-2):206-14
17316694
J Biol Chem. 2004 Dec 24;279(52):54518-28
15475565
Proc Natl Acad Sci U S A. 2004 Jun 29;101(26):9861-6
15210974
J Neuropathol Exp Neurol. 2004 Apr;63(4):287-301
15099019
J Neurosci. 2007 Mar 7;27(10):2472-82
17344385
J Neurosci Res. 2002 Nov 1;70(3):462-73
12391607
Mol Neurodegener. 2009 Jul 14;4:28
19602287
J Neuropathol Exp Neurol. 2004 May;63(5):418-28
15198121
Neurobiol Aging. 2008 Jan;29(1):51-70
17055614
Histol Histopathol. 2004 Apr;19(2):495-504
15024710
Mol Cell Neurosci. 2002 Oct;21(2):312-23
12401450
Neurobiol Dis. 2007 Oct;28(1):52-64
17656100
Eur Arch Psychiatry Clin Neurosci. 2009 Mar;259(2):72-9
18806920
J Neurosci. 2006 Oct 25;26(43):11208-19
17065460
Science. 1998 Apr 24;280(5363):517-9
9575095
IUBMB Life. 2007 Apr-May;59(4-5):316-21
17505971
Growth Factors. 2005 Jun;23(2):111-6
16019432
J Inorg Biochem. 2007 Sep;101(9):1265-9
17629564
Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12667-72
10535980
Neurosci Lett. 2003 Jul 3;344(3):185-8
12812836
Cell Tissue Res. 2007 Sep;329(3):409-20
17541643
Gene. 2005 Jan 3;344:259-71
15656992
Glia. 2008 Dec;56(16):1767-79
18649403
J Biol Chem. 2001 Aug 10;276(32):30142-9
11387343
Int Rev Neurobiol. 2004;59:221-54
15006490
Neurosci Res. 2009 Mar;63(3):199-204
19135101
J Biol Chem. 2009 Jul 10;284(28):18824-32
19439407
Mol Biol Cell. 2006 Jun;17(6):2572-80
16571670
Curr Alzheimer Res. 2008 Feb;5(1):15-25
18288927
Neurochem Int. 2009 Dec;55(7):606-9
19524002
J Biol Chem. 2006 Sep 29;281(39):29268-77
16849336
J Neurosci. 2008 May 28;28(22):5641-53
18509025
J Psychiatr Res. 2009 Oct;43(15):1195-9
19435634
Proc Natl Acad Sci U S A. 1997 May 13;94(10):5296-301
9144231
Int J Oncol. 2002 Oct;21(4):895-900
12239632
Magn Reson Med. 2004 Apr;51(4):794-8
15065253
J Neurosci. 2004 Jun 30;24(26):6021-7
15229249
Acta Neurol Scand Suppl. 2000;176:53-9
11261806
Neurobiol Aging. 2006 Nov;27(11):1618-31
16274856
FEBS Lett. 2001 Sep 7;505(1):18-22
11557034
PLoS One. 2007 Sep 05;2(9):e817
17786189
Cereb Cortex. 2009 Jul;19 Suppl 1:i62-9
19366868
Proc Natl Acad Sci U S A. 1992 Aug 1;89(15):6818-22
1495970
J Biol Chem. 2005 Apr 8;280(14):13616-23
15699046
Neurosci Lett. 2002 Mar 8;320(3):156-60
11852185
Science. 2008 Mar 21;319(5870):1665-8
18356527
J Biol Chem. 2002 Jul 19;277(29):26379-88
12006563
Neurobiol Dis. 2008 Oct;32(1):162-75
18691652
BMC Genomics. 2008 Mar 03;9:114
18315872
J Neurosci. 2003 Oct 22;23(29):9500-7
14573529
Neuroscience. 1999;94(4):1279-90
10625067
BMC Neurosci. 2007 Mar 13;8:20
17355637
Synapse. 2000 Dec 15;38(4):450-9
11044892
Biol Chem. 2004 Mar-Apr;385(3-4):285-9
15134342
Neurobiol Aging. 2008 Jun;29(6):795-811
17313996
J Neural Transm Suppl. 1995;46:139-47
8821049
J Neurochem. 2006 Feb;96(4):1005-15
16412093
Nat Rev Neurosci. 2002 Nov;3(11):862-72
12415294
Am J Psychiatry. 2009 Jun;166(6):718-25
19448189
Neurobiol Learn Mem. 2008 Feb;89(2):87-94
17638582
Ann N Y Acad Sci. 2003 Dec;1010:639-42
15033804
Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11771-5
19556537
Lancet Neurol. 2002 Sep;1(5):279-84
12849425
Biochem Soc Trans. 2005 Nov;33(Pt 5):1041-4
16246041
J Neurosci. 2008 Jan 30;28(5):1034-45
18234882
Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20947-52
19098102
J Biol Chem. 1999 Sep 17;274(38):26810-4
10480887
Front Neurosci. 2008 Jul 07;2(1):47-55
18982106
J Neurosci Res. 2005 Sep 15;81(6):753-61
16035109
Eur J Neurosci. 2002 Jun;15(11):1766-78
12081656
Neurochem Res. 2008 May;33(5):902-11
17999181
Brain Res Rev. 2008 Mar;57(2):531-53
17524488
J Neurobiol. 1995 Jan;26(1):145-61
7536234
Exp Neurol. 2009 Apr;216(2):459-70
19320004
J Neurosci. 2006 Feb 1;26(5):1624-34
16452686
Biochem Biophys Res Commun. 2009 Aug 14;386(1):257-62
19523444
J Biol Chem. 2007 Aug 10;282(32):23553-60
17575274
Prog Neuropsychopharmacol Biol Psychiatry. 2006 Dec 30;30(8):1369-80
16793187
Mol Psychiatry. 2009 Jun;14(6):563-89
19204725
Rev Neurosci. 2006;17(1-2):43-52
16703942
Gene. 2000 Apr 18;247(1-2):63-75
10773445
J Neurosci. 1999 Jul 1;19(13):5360-9
10377346
J Neurochem. 2002 Sep;82(6):1388-97
12354286
Pol J Pharmacol. 2003 Sep-Oct;55(5):915-7
14704487
J Neuropathol Exp Neurol. 2002 Apr;61(4):358-67
11939591
Adv Exp Med Biol. 2006;572:341-8
17249594
Hum Mol Genet. 2006 Jun 15;15(12):1949-62
16687443
Rinsho Shinkeigaku. 2006 Jan;46(1):1-18
16541790
J Neurosci Res. 2004 Aug 1;77(3):420-9
15248298
Nat Methods. 2007 Dec;4(12):1045-9
18026111
FASEB J. 2008 Jan;22(1):138-45
17687114
Cereb Cortex. 1992 Jan-Feb;2(1):56-67
1633408
J Neurosurg. 2008 Oct;109(4):691-8
18826357
Methods Mol Med. 2008;141:131-51
18453088
J Cell Physiol. 2009 Feb;218(2):294-303
18844239
J Neurochem. 1998 Jul;71(1):356-65
9648885
J Biol Chem. 1998 Jul 31;273(31):19708-14
9677400
Exp Neurol. 1999 Nov;160(1):289-99
10630213
J Biol Chem. 2005 Apr 1;280(13):12467-73
15632121
Brain Res. 2001 Jun 29;905(1-2):250-3
11423103
J Neurosci. 2008 Nov 19;28(47):12255-67
19020019
Mol Vis. 2007 May 14;13:719-23
17563722
BMC Neurosci. 2007 Nov 16;8:95
18021406
Bioconjug Chem. 2007 Sep-Oct;18(5):1397-407
17722875
Exp Neurol. 2002 May;175(1):226-44
12009775
Science. 2004 May 7;304(5672):839-43
15073322
Neuron. 1999 Dec;24(4):1003-16
10624962
Cell Mol Neurobiol. 2007 Nov;27(7):943-57
17965932
Am J Hum Genet. 2008 Oct;83(4):504-10
18940311
Biochim Biophys Acta. 2007 Feb;1773(2):254-63
17150266
J Neurosci. 1994 Nov;14(11 Pt 1):6652-66
7965067
Neuropathol Appl Neurobiol. 2002 Jun;28(3):238-51
12060348
J Proteomics. 2009 Feb 15;72(1):82-90
19022416
J Neurosci. 2003 Mar 1;23(5):1649-58
12629169
Neurobiol Aging. 2009 Jan;30(1):71-80
17601638
J Cell Mol Med. 2003 Oct-Dec;7(4):351-61
14754504
Mol Biol Cell. 2006 Oct;17(10):4179-86
16855020
J Proteome Res. 2009 Jul;8(7):3633-41
19441803
Brain Res. 1994 Jul 4;650(1):20-31
7953673
Brain Res. 1994 Mar 7;639(1):171-4
7514086
Gene Expr. 2006;13(1):27-40
16572588
Gene. 2004 Aug 4;337:163-71
15276212
Neurosci Lett. 1998 Aug 7;252(1):33-6
9756352
Exp Neurol. 2007 Apr;204(2):828-31
17291498
Science. 2006 Oct 27;314(5799):664-6
16990514
Mol Cell Neurosci. 2009 Apr;40(4):433-41
19171194
J Neurosci Res. 1991 Aug;29(4):490-8
1791640
J Biol Chem. 2000 Nov 17;275(46):36204-10
10958799
J Glaucoma. 2007 Mar;16(2):230-3
17473736
Exp Eye Res. 2006 Jul;83(1):97-119
16545802
J Neurophysiol. 2007 Oct;98(4):2244-54
17715197
Rinsho Shinkeigaku. 2004 Nov;44(11):991-4
15651351
Clin Chem. 2008 Oct;54(10):1617-23
18703769
Mol Cell Neurosci. 2008 Jan;37(1):40-55
17920294
Comput Biol Chem. 2005 Apr;29(2):151-62
15833443
Funct Neurol. 2003 Jul-Sep;18(3):145-8
14703895
Stem Cells. 2008 Aug;26(8):2019-31
18467660
Biosci Rep. 2005 Oct-Dec;25(5-6):309-27
16307379
Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12151-5
19581597
J Neural Transm (Vienna). 2002 Mar;109(3):341-60
11956956
IUBMB Life. 2002 Nov;54(5):253-60
12587975
Proc Natl Acad Sci U S A. 2007 Jan 30;104(5):1691-6
17242369
Cell Mol Life Sci. 1999 Apr;55(4):564-74
10357227
J Neurochem. 2005 Feb;92(3):607-15
15659230
FEBS Lett. 2002 May 8;518(1-3):1-4
11997007
J Biol Chem. 2008 Jan 4;283(1):100-109
17971449
Ann N Y Acad Sci. 1999;893:290-3
10672251
Biochem Biophys Res Commun. 2007 Mar 9;354(2):505-10
17250808
Biochem Biophys Res Commun. 2001 Dec 21;289(5):1039-43
11741295
J Neurosci Res. 2008 Mar;86(4):785-96
17918747
Ann Neurol. 2002 Nov;52(5):691-3
12402277
C R Seances Soc Biol Fil. 1993;187(6):726-36
7834495
BMC Cell Biol. 2007 Jun 12;8:22
17565660
Am J Med Genet B Neuropsychiatr Genet. 2010 Jan 5;153B(1):114-9
19367585
Microvasc Res. 2008 Apr;75(3):411-9
18048067
J Neurosci Res. 2008 Mar;86(4):744-54
17828772
Curr Mol Med. 2009 May;9(4):506-18
19519407
J Neurosci. 2008 Nov 12;28(46):11871-82
19005052
J Neurochem. 2007 Oct;103(1):190-203
17635665
Front Behav Neurosci. 2007 Dec 30;1:6
18958188
Trends Pharmacol Sci. 2003 May;24(5):233-8
12767722
Glia. 2001 Jul;35(1):72-9
11424194
Neurodegener Dis. 2006;3(6):334-7
17192722
Biomed Pharmacother. 2007 Aug;61(7):390-9
17178208
Curr Alzheimer Res. 2008 Jun;5(3):233-43
18537540
FEBS Lett. 2006 May 29;580(13):3121-8
16684527
Nat Genet. 2004 Jun;36(6):602-6
15122254
Hum Mol Genet. 2008 Oct 15;17(20):3191-203
18647754
Biochem Biophys Res Commun. 1993 Dec 15;197(2):755-62
8267612
PLoS Genet. 2009 Feb;5(2):e1000373
19197363
Proc Natl Acad Sci U S A. 1988 Mar;85(6):1998-2002
2450354
Eur J Clin Invest. 2002 May;32(5):360-71
12027877
Neuron. 2007 May 24;54(4):583-97
17521571
J Biol Chem. 2002 Nov 15;277(46):43844-8
12223487
J Comp Neurol. 2006 Feb 10;494(5):784-91
16374807
J Inorg Biochem. 2007 Sep;101(9):1275-84
17662457
Mol Cell Biol. 2007 Jun;27(12):4228-37
17438127
Curr Neurol Neurosci Rep. 2009 May;9(3):188-97
19348707
Alzheimer Dis Assoc Disord. 1995;9 Suppl 2:15-22
8534418
Gene Expr Patterns. 2006 Jan;6(2):134-40
16326148
Brain Res Brain Res Protoc. 2003 Oct;12(2):104-8
14613812
J Neurosci. 2004 Feb 11;24(6):1507-20
14960624
Stem Cell Rev. 2007 Jan;3(1):30-8
17873379
Neurobiol Aging. 2002 May-Jun;23(3):349-62
11959396
J Biol Chem. 2001 Dec 21;276(51):48510-7
11600492
Nat Neurosci. 2004 Oct;7(10):1079-87
15452577
Mol Biol Cell. 2007 Apr;18(4):1490-6
17314396
Eur J Neurosci. 2005 Oct;22(8):1942-50
16262633
Vertex. 2006 May-Jun;17(67):165-71
16847474
Physiol Genomics. 2008 Feb 19;32(3):370-9
18056785
Proc Natl Acad Sci U S A. 2009 Jul 7;106(27):11364-9
19541599
Life Sci. 2008 Jun 6;82(23-24):1137-41
18468644
Schizophr Res. 2006 Feb 28;82(2-3):175-83
16414245
J Neurochem. 1993 Jul;61(1):29-44
7685814
Cold Spring Harb Symp Quant Biol. 2007;72:645-54
18419324
J Med Genet. 2008 Apr;45(4):239-43
18057082
Biochem Biophys Res Commun. 1999 Oct 14;264(1):247-52
10527873
Biochem Biophys Res Commun. 2001 Mar 2;281(3):815-20
11237732
Dev Neurosci. 2007;29(3):232-40
17047319
Learn Mem. 2006 Sep-Oct;13(5):599-608
17015857
J Transl Med. 2009 Jan 20;7:8
19152710
Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2525-30
17287346
Neurochem Res. 2005 Feb;30(2):277-87
15895832
Am J Pathol. 1993 May;142(5):1574-85
8494052
J Biol Chem. 2007 Mar 16;282(11):8464-73
17224447
J Neurosci. 2005 Jul 27;25(30):7062-70
16049183
PLoS One. 2007 Aug 29;2(8):e804
17726534
Biosystems. 2007 Mar;88(1-2):56-75
16870322
Nat Neurosci. 1999 Aug;2(8):706-12
10412059
Acta Biochim Pol. 2003;50(3):775-82
14515157
Ann N Y Acad Sci. 2008 Nov;1144:97-112
19076369
J Neurol Sci. 1994 Jul;124(2):141-8
7964864
Genes Cells. 2007 May;12(5):561-7
17535247
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2009 Jan;34(1):63-6
19197130
Stem Cells. 2008 Jan;26(1):173-81
17901403
Biochem Soc Trans. 2005 Nov;33(Pt 5):1033-6
16246039
Bipolar Disord. 2008 Feb;10(1):105-10
18199248
Eur J Neurosci. 1995 Apr 1;7(4):702-13
7620619
Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2273-6
15695586
Proc Natl Acad Sci U S A. 1994 May 24;91(11):4902-6
8197154
Biol Psychiatry. 2001 Mar 15;49(6):547-52
11257240
J Biol Chem. 2006 Sep 29;281(39):28858-64
16887799
Curr Opin Hematol. 1998 May;5(3):181-5
9664157
J Clin Invest. 2008 Sep;118(9):3075-86
18704195
J Biol Chem. 2006 Sep 1;281(35):25457-65
16803897
Neuroscience. 2009 Jul 21;161(4):978-87
19362124
Biol Psychiatry. 2009 Jan 15;65(2):150-9
18823877
J Neurosci. 2008 Feb 6;28(6):1421-6
18256262
Eur J Neurosci. 2007 Nov;26(9):2469-72
17986027