title: [Thrombolysis in acute coronary syndrome].
abstract: The prognosis of acute myocardial infarction(AMI) is greatly influenced by the time to recanalization after onset. Although thrombolysis has the advantage of universal availability and short time to administration, Thrombolysis in Myocardial Infarction(TIMI) grade 3 reperfusion is less achieved by thrombolysis than percutaneous coronary intervention. Additionally, hemorrhagic complications are feared in thrombolysis. For the purpose of improving those disadvantages. we tested the efficacy of combining the transcutaneous ultrasound with a pharmacological thrombolysis in the rabbit femoral artery occlusion model with the platelet and fibrin-rich thrombus like AMI. The results of our experimental study suggest the possible benefit of using transcutaneous ultrasound to facilitate thrombolysis in the acute arterial thrombotic diseases including AMI.
authors.affiliation: First Department of Internal Medicine, Nara Medical University.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawata
mesh_terms: D054058:Acute Coronary Syndrome; D000818:Animals; D006801:Humans; D011817:Rabbits; D015912:Thrombolytic Therapy / Q000379:methods*; D014464:Ultrasonic Therapy