Synthesis and preliminary biological evaluation of chrysin derivatives as potential anticancer drugs.
A series of chrysin derivatives were prepared from 2-hydroxyacetophenone, 2,4-dihydroxyacetophenone, 2,4,6-trihydroxy- acetophenone, using modified Baker-Venkataraman transformation. Their anticancer activities in vitro were evaluated by the standard MTT method. The results of biological test showed that some of chrysin derivatives showed stronger anticancer activity than 5-fluorouracil.
Zheng
Xing
X
Institute of Pharmacy & Pharmacology, University of South China, Hengyang, 421001, China. zhengxing5018@yahoo.com
Zhao
Fei Fei
FF
Liu
Yun Mei
YM
Yao
Xu
X
Zheng
Zi Tong
ZT
Luo
Xing
X
Liao
Duan Fang
DF
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50
D000970:Antineoplastic Agents; D005419:Flavonoids; C043561:chrysin