Novel anti-infective compounds from marine bacteria.
As a result of the continuous evolution of microbial pathogens towards antibiotic-resistance, there have been demands for the development of new and effective antimicrobial compounds. Since the 1960s, the scientific literature has accumulated many publications about novel pharmaceutical compounds produced by a diverse range of marine bacteria. Indeed, marine micro-organisms continue to be a productive and successful focus for natural products research, with many newly isolated compounds possessing potentially valuable pharmacological activities. In this regard, the marine environment will undoubtedly prove to be an increasingly important source of novel antimicrobial metabolites, and selective or targeted approaches are already enabling the recovery of a significant number of antibiotic-producing micro-organisms. The aim of this review is to consider advances made in the discovery of new secondary metabolites derived from marine bacteria, and in particular those effective against the so called "superbugs", including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin resistant enterococci (VRE), which are largely responsible for the increase in numbers of hospital acquired, i.e., nosocomial, infections.
Rahman
Hafizur
H
School of Life Sciences, Heriot-Watt University, Riccarton, Edinburgh EH144AS, Scotland, UK. h.rahman@hw.ac.uk
Austin
Brian
B
Mitchell
Wilfrid J
WJ
Morris
Peter C
PC
Jamieson
Derek J
DJ
Adams
David R
DR
Spragg
Andrew Mearns
AM
Schweizer
Michael
M
D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification; D001419:Bacteria / Q000737:chemistry*; D001688:Biological Products / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D055808:Drug Discovery; D016983:Enterococcus / Q000187:drug effects; D008386:Marine Biology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D020713:Vancomycin Resistance; D014871:Water Microbiology
D000890:Anti-Infective Agents; D001688:Biological Products
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