Cardiac tamponade and heart failure due to myopericarditis as a presentation of infection with the pandemic H1N1 2009 influenza A virus.
We describe a fatal case of myopericarditis presenting with cardiac tamponade in a previously healthy 11-year-old child. Pandemic H1N1 2009 influenza A virus sequences were identified in throat and myocardial tissues and pericardial fluid, suggesting damage of myocardial cells directly caused by the virus.
Puzelli
Simona
S
Istituto Superiore di Sanità (ISS), National Institute of Health, Rome, Italy. simona.puzelli@iss.it
Buonaguro
Franco M
FM
Facchini
Marzia
M
Palmieri
Annapina
A
Calzoletti
Laura
L
De Marco
Maria A
MA
Arace
Pasquale
P
de Campora
Enrico
E
Esposito
Ciro
C
Cassone
Antonio
A
Rezza
Giovanni
G
Donatelli
Isabella
I
D002305:Cardiac Tamponade / Q000150:complications* / Q000175:diagnosis*; D002648:Child; D005260:Female; D006321:Heart / Q000821:virology; D006333:Heart Failure / Q000175:diagnosis*; D006651:Histocytochemistry; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000150:complications / Q000175:diagnosis*; D008853:Microscopy; D009206:Myocardium / Q000473:pathology; D009220:Myositis / Q000150:complications / Q000175:diagnosis*; D010490:Pericardial Effusion / Q000821:virology; D010493:Pericarditis / Q000150:complications / Q000175:diagnosis*; D010614:Pharynx / Q000821:virology
J Biol Chem. 1994 Apr 8;269(14):10637-43
8144653
J Am Coll Cardiol. 2003 Aug 6;42(3):466-72
12906974
Arch Intern Med. 2003 Jan 27;163(2):165-8
12546606
Lancet Infect Dis. 2009 Oct;9(10):601-10
19778762
Intern Med. 2001 Jul;40(7):594-7
11506298
Mod Pathol. 2004 Sep;17(9):1108-18
15218506
Wkly Epidemiol Rec. 2010 Jan 22;85(4):21-2
20095109
J Cardiol. 2001 Jun;37(6):315-23
11433807
Acta Med Scand. 1980;207(1-2):27-30
7368969
J Am Coll Cardiol. 2010 Mar 2;55(9):928-9
20153131
Pediatrics. 2006 Sep;118(3):e610-9
16950953
Int J Cardiol. 2008 Nov 28;130(3):304-9
18625525