Relationship between essential tremor and cerebellar dysfunction according to age.
BACKGROUND
The cerebellum and its neural circuitry have been assumed to play a major role in the pathophysiology of essential tremor (ET). In this study, we sought to find associations between ET and cerebellar dysfunction.


METHODS
We performed tandem gait test in 41 ET patients and 44 age-matched controls. Investigators assessed tandem gait by counting the number of missteps during ten-step tandem walk and each subject repeated the trial three times.


RESULTS
ET patients had a higher average and total numbers of missteps during tandem gait tests than control subjects (p<0.05). Sex-adjusted odds ratio of the association between tandem gait abnormality and ET was 3.40 (95% confidence intervals 1.06-10.85). According to age stratification, aged ET patients (age >/=70 years) showed significantly higher prevalence of tandem gait abnormality than young ones. Interaction terms determined by a likelihood ratio test was also statistically significant (p<0.05).


CONCLUSIONS
Dysfunction of cerebellar neural circuitry may be associated with the pathophysiological mechanism of ET. In addition, aging may be an important factor modifying the association.
Lim
Eui-Seong
ES
Department of Neurology, Chonbuk National University College of Medicine, Jeonju, Korea.
Seo
Man-Wook
MW
Woo
Seong-Ryong
SR
Jeong
Suk-Young
SY
Jeong
Seul-Ki
SK
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