Role of monocytes and macrophages in experimental and human acute liver failure.
Acute liver failure (ALF) is a devastating clinical syndrome characterised by progressive encephalopathy, coagulopathy, and circulatory dysfunction, which commonly leads to multiorgan failure and death. Central to the pathogenesis of ALF is activation of the immune system with mobilisation of cellular effectors and massive production of cytokines. As key components of the innate immune system, monocytes and macrophages are postulated to play a central role in the initiation, progression and resolution of ALF. ALF in humans follows a rapidly progressive clinical course that poses inherent difficulties in delineating the role of these pivotal immune cells. Therefore, a number of experimental models have been used to study the pathogenesis of ALF. Here we consider the evidence from experimental and human studies of ALF on the role of monocytes and macrophages in acute hepatic injury and the ensuing extrahepatic manifestations, including functional monocyte deactivation and multiple organ failure.
Possamai
Lucia A
LA
Antoniades
Charalambos Gustav
CG
Anstee
Quentin M
QM
Quaglia
Alberto
A
Vergani
Diego
D
Thursz
Mark
M
Wendon
Julia
J
D000818:Animals; D018932:Chemokine CCL2 / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D007107:Immune System; D007249:Inflammation; D008099:Liver / Q000293:injuries / Q000378:metabolism / Q000473:pathology; D017093:Liver Failure / Q000097:blood* / Q000378:metabolism; D008264:Macrophages / Q000166:cytology* / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009000:Monocytes / Q000166:cytology*; D051381:Rats
C111835:CCL2 protein, human; D018932:Chemokine CCL2; D016207:Cytokines
Am J Pathol. 2009 May;174(5):1766-75
19359521
Gastroenterology. 2000 Aug;119(2):446-60
10930380
J Immunol. 1997 Dec 1;159(11):5576-84
9548499
Hepatology. 1997 Dec;26(6):1513-20
9397992
J Hepatol. 1999 Nov;31(5):815-24
10580578
Intensive Care Med. 1998 Mar;24(3):224-9
9565803
Chem Res Toxicol. 2002 Dec;15(12):1504-13
12482232
J Clin Invest. 2003 Oct;112(7):978-80
14523032
Semin Liver Dis. 2003 Aug;23(3):217-26
14523675
Br J Surg. 1990 Feb;77(2):204-7
2317682
J Pathol. 1998 Sep;186(1):82-9
9875144
J Clin Pharmacol. 2005 Oct;45(10):1165-71
16172181
Hepatology. 1999 Jul;30(1):186-95
10385655
Nat Immunol. 2006 Mar;7(3):311-7
16462739
J Hepatol. 2007 Nov;47(5):671-6
17629586
Hepatology. 1990 Jan;11(1):49-53
2295471
J Gene Med. 2009 Mar;11(3):229-39
19189285
Hepatology. 2000 Oct;32(4 Pt 1):734-9
11003617
World J Gastroenterol. 2009 Jul 7;15(25):3086-98
19575487
J Pathol. 2003 Mar;199(3):335-44
12579535
Hepatology. 1999 Jun;29(6):1752-9
10347118
Hepatology. 2009 Jul;50(1):261-74
19554540
J Hepatol. 2008 Nov;49(5):845-61
18801592
Biochem Biophys Res Commun. 2003 Apr 25;304(1):207-12
12705907
J Immunol. 2009 Aug 15;183(4):2810-7
19620305
Chem Res Toxicol. 2007 Feb;20(2):208-16
17305405
Gastroenterology. 2002 Jan;122(1):202-10
11781294
Clin Exp Immunol. 2007 Jan;147(1):184-8
17177978
Hepatology. 1997 Jun;25(6):1382-9
9185757
J Immunol. 2003 May 15;170(10):5252-9
12734374
Liver Int. 2009 Apr;29(4):536-43
18795898
J Interferon Cytokine Res. 2001 Dec;21(12):1055-62
11798463
J Immunol. 1997 Aug 1;159(3):1418-28
9233639
FASEB J. 2002 Aug;16(10):1227-36
12153990
Clin Exp Immunol. 1994 Oct;98(1):71-7
7923888
Hepatology. 1996 Jun;23(6):1608-15
8675184
J Biol Chem. 2001 Jul 13;276(28):26605-13
11349125
Hepatology. 2000 Jan;31(1):149-59
10613740
Gastroenterology. 1997 Mar;112(3):935-42
9041256
J Immunol. 2004 May 1;172(9):5648-55
15100309
Hepatology. 2006 Jul;44(1):34-43
16799971
J Leukoc Biol. 2008 Dec;84(6):1410-21
18713872
Hepatology. 1995 Apr;21(4):1045-50
7705777
Biochem Biophys Res Commun. 2002 Jun 7;294(2):225-30
12051698
Am J Pathol. 1995 May;146(5):1220-34
7538266
Gastroenterology. 1996 Sep;111(3):736-44
8780580
J Infect Dis. 2000 Oct;182(4):1103-8
10979906
Hepatology. 1995 Jan;21(1):190-8
7806154
J Hepatol. 2005 Feb;42(2):195-201
15664244
J Immunol. 2008 Oct 15;181(8):5579-86
18832716
J Exp Med. 1994 Jun 1;179(6):1895-902
8195715
Gut. 1994 Jul;35(7):982-6
8063228
Am J Pathol. 1997 Jan;150(1):235-46
9006339
Hepatology. 2002 Feb;35(2):289-98
11826401
Biochem Biophys Res Commun. 2003 Oct 3;309(4):857-63
13679052
Oncogene. 2002 Jan 3;21(1):32-43
11791174
Hepatology. 1998 Dec;28(6):1597-606
9828224
Hepatology. 2002 May;35(5):1093-103
11981759
Toxicol Appl Pharmacol. 2006 Mar 1;211(2):157-65
16081117
Gastroenterology. 1997 Mar;112(3):923-34
9041255
J Exp Med. 1994 May 1;179(5):1529-37
8163936
J Gastroenterol. 2005 Jan;40(1):52-6
15692789
Am J Pathol. 2000 Apr;156(4):1245-52
10751350
Hepatology. 1998 Dec;28(6):1607-15
9828225
Hepatology. 1990 Nov;12(5):1187-91
2227817
Nat Med. 1997 Jun;3(6):678-81
9176497