Oxepinochromenones, furochromenone, and their putative precursors from the endolichenic fungus Coniochaeta sp.
Six new polyketides including four oxepinochromenones, conioxepinols A-D (1-4), one furochromenone, coniofurol A (5), and one xanthone, conioxanthone A (6), have been isolated from the crude extract of the endolichenic fungus Coniochaeta sp. The absolute configurations of C-7 in 1 and the 7,8-diol moiety in 3 were assigned using the modified Mosher's and Snatzke's method, respectively, whereas that of C-8 in 5 was deduced via the circular dichroism data of the [Rh(2)(OCOCF(3))(4)] complex. Compounds 2-4 showed modest cytotoxicity against a small panel of human tumor cell lines.
Wang
Yinchao
Y
Key Laboratory of Systematic Mycology & Lichenology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
Zheng
Zhihui
Z
Liu
Shuchun
S
Zhang
Hua
H
Li
Erwei
E
Guo
Liangdong
L
Che
Yongsheng
Y
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001203:Ascomycota / Q000737:chemistry*; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008011:Lichens / Q000382:microbiology; D015394:Molecular Structure
D000970:Antineoplastic Agents; D003374:Coumarins