[Phospholipid content of plasma membranes and phospholipase C activity in epithelial cells of the large intestine in colitis-associated carcinogenesis in rats].
The decrease of major cytoplasmic membrane phospholipids (phosphatidylcholine and phosphatidylethanolamine) content was established in mucosal epithelial cell under colon inflammation pathology--ulcerative colitis. It was shown that aforementioned changes were associated with the increase of phospholipids' hydrolyzing enzyme--phospholipase C activity and intracellular Ca2+ concentration enlargement. Carcinogenesis stimulation under inflammation was accompanied by phospholipase C activity increase when quantity of investigated phospholipids (phosphatidylcholine, phosphatidylinozytol, phosphatidylserine) separately decreased and cytoplasmic Ca2+ value normalization was established.
Drobins'ka
O V
OV
Kravchenko
O O
OO
Koval'ova
V A
VA
Artemenko
O Iu
OIu
Ostapchenko
L I
LI
D019813:1,2-Dimethylhydrazine; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D003093:Colitis, Ulcerative / Q000150:complications* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D003106:Colon / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D003110:Colonic Neoplasms / Q000201:enzymology / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D003600:Cytosol / Q000378:metabolism; D016264:Dextran Sulfate; D004195:Disease Models, Animal; D004847:Epithelial Cells / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D007413:Intestinal Mucosa / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008297:Male; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D010738:Type C Phospholipases / Q000378:metabolism*
D010743:Phospholipids; D016264:Dextran Sulfate; D010738:Type C Phospholipases; D019813:1,2-Dimethylhydrazine; D002118:Calcium