Naloxone effects on behavior of inbred mice with different response to emotional stress in open field test.
Effects of nonspecific opiate receptor antagonist naloxone in doses of 0.1, 0.5, 1.0, 5.0, 10.0 mg/kg on open field behavior and spontaneous motor activity were studied in male BALB/c and C57Bl/6 mice. Differently directed effects of naloxone on behavioral parameters of emotional-stress reaction in BALB/c and C57Bl/6 mice were observed. Naloxone increased motor activity in the open field test in BALB/c mice, but decreased it in C57Bl/6 mice. In the absence of stress, naloxone in the studied dose range did not affect spontaneous motor activity in C57Bl/6 mice, and significantly reduced activity in BALB/c mice in doses 0.5 and 1.0 mg/kg.
Nadorova
A V
AV
Department of Pharmacogenetics V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. av-nadorova@mail.ru
Kozlovskaja
M M
MM
Seredenin
S B
SB
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D009483:Neuropsychological Tests; D013315:Stress, Psychological
D009292:Narcotic Antagonists; D009270:Naloxone