Spontaneous postpartum resolution of vision loss caused by a progesterone receptor-positive tuberculum sellae meningioma.
A 27-year-old pregnant woman reported progressive loss of vision. Brain MRI disclosed an intracranial mass compressing the optic nerves and chiasm with imaging features suggestive of meningioma. Because delivery was imminent, surgical removal was deferred. Within a few days after delivery, the patient noted improvement in vision. Subsequent neuro-ophthalmological evaluations documented almost complete visual recovery within 2 months postpartum. The mass was removed surgically at 10 months postpartum. It was a grade I meningioma with progesterone cell surface receptors. The patient's visual function has remained stable during a follow-up of 14 months. This is the first reported case with full visual function and MRI documentation of spontaneous postpartum visual recovery in a progesterone receptor-positive meningioma compressing the anterior visual pathway.
Chacko
Joseph G
JG
Department of Ophthalmology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. jchacko@uams.edu
Miller
Jessica L
JL
Angtuaco
Edgardo J
EJ
D000328:Adult; D003399:Craniotomy; D019299:Decompression, Surgical; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D008579:Meningioma / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism; D019635:Neurosurgical Procedures; D009897:Optic Chiasm / Q000473:pathology / Q000503:physiopathology; D009900:Optic Nerve / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy / Q000502:physiology; D011248:Pregnancy Complications / Q000378:metabolism / Q000503:physiopathology; D011374:Progesterone / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism*; D012658:Sella Turcica / Q000473:pathology*; D016896:Treatment Outcome; D015354:Vision, Low / Q000209:etiology*; D014795:Visual Pathways / Q000473:pathology* / Q000503:physiopathology
D011980:Receptors, Progesterone; D011374:Progesterone