title: Safety, effectiveness, and subjective experience with topical bimatoprost 0.03% for eyelash growth.
abstract: BACKGROUND
  Ocularly applied bimatoprost 0.03% is associated with increased eyelash growth.
  
  
  OBJECTIVE
  To assess the safety, efficacy, and subjective experience of using dermal application of bimatoprost 0.03% for the growth of natural eyelashes.
  
  
  METHODS
  Prospective, open-label study of subjects who desired longer, thicker (fuller), and darker natural eyelashes. Bimatoprost was applied to the upper lid margin once daily for 12 weeks. Adverse events and intraocular pressure were assessed, and subjects completed health outcomes questionnaires. Eyelash growth and darkening were scored using photographs taken at weeks 1 and 12.
  
  
  RESULTS
  All subjects were female (N=28). No serious or unexpected adverse events were reported. The mean change from baseline intraocular pressure was less than 1 mmHg at each time point, but was statistically significant at weeks 1 and 4 (p< or =.047). At week 12, all subjects had noticed significant growth or darkening. Post hoc analysis of photographs corroborated these reports (p<.001).
  
  
  CONCLUSIONS
  Bimatoprost was found safe for eyelid application and was associated with enhanced eyelash growth. All subjects noticed favorable changes in the appearance of their eyelashes.
authors.affiliation: syoelinmd@aol.com
authors.forename: Steve
authors.initials: S
authors.lastname: Yoelin
authors.forename: John G
authors.initials: JG
authors.lastname: Walt
authors.forename: Melissa
authors.initials: M
authors.lastname: Earl
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000577:Amides / Q000008:administration & dosage*; D000959:Antihypertensive Agents / Q000008:administration & dosage; D000069580:Bimatoprost; D003008:Cloprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005140:Eyelashes / Q000187:drug effects / Q000254:growth & development*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D000577:Amides; D000959:Antihypertensive Agents; D003008:Cloprostenol; D000069580:Bimatoprost