The genuine ligand of a jasmonic acid receptor: improved analysis of jasmonates is now required.
Jasmonic acid (JA), its metabolites, such as the methyl ester or amino acid conjugates as well as its precursor 12-oxophytodienoic acid (OPDA) are lipid-derived signals. JA, OPDA and JA-amino acid conjugates are known to function as signals in plant stress responses and development. More recently, formation of JA-amino acid conjugates and high biological activity of JA-Isoleucine (JA-Ile) were found to be essential in JA signaling. A breakthrough was the identification of JAZ proteins which interact with the F-box protein COI1 if JA-Ile is bound. This interaction leads to proteasomal degradation of JAZs being negative regulators of JA-induced transcription. Surprisingly, a distinct stereoisomer of JA-Ile, the (+)-7-iso-JA-Ile [(3R,7S) form] is most active. Coronatine, a bacterial phytotoxine with an identical stereochemistry at the cyclopentanone ring, has a similar bioactivity. This was explained by the recent identification of COI1 as the JA receptor and accords well with molecular modeling studies. Whereas over the last two decades JA was quantified to describe any JA dependent process, now we have to take into account a distinct stereoisomer of JA-Ile. Until recently a quantitative analysis of (+)-7-iso-JA-Ile was missing presumable due to its equilibration to (-)-JA-Ile. Now such an analysis was achieved. These aspects will be discussed based on our new knowledge on JA perception and signaling.
Wasternack
Claus
C
Leibniz Institute of Plant Biochemistry, Halle/Saale, Germany. cwastern@ipb-halle.de
Xie
Daoxin
D
D000596:Amino Acids / Q000737:chemistry; D003517:Cyclopentanes / Q000737:chemistry / Q000378:metabolism*; D007192:Indenes / Q000737:chemistry; D007532:Isoleucine / Q000031:analogs & derivatives / Q000737:chemistry; D008024:Ligands; D054883:Oxylipins / Q000737:chemistry / Q000378:metabolism*; D010944:Plants / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction
D000596:Amino Acids; D003517:Cyclopentanes; D007192:Indenes; D008024:Ligands; D054883:Oxylipins; C532883:jasmonoyl-isoleucine; D007532:Isoleucine; C058487:coronatine; C011006:jasmonic acid
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