[Tumor regression in malignant choroidal melanomas after transpupillary thermotherapy (TTT) versus ruthenium brachytherapy and sandwich therapy - a comparative analysis].
OBJECTIVE
The aim of this study was to evaluate tumour regression in a large series of choroidal melanomas, which were treated with three different eye-sparing treatment modalities.


METHODS
Retrospective review of the treatment results in all eyes with malignant choroidal melanoma, which were treated in the University Eye Clinic of Mainz consecutively in the time span 1.1992 to 12.2000 with transpupillary thermotherapy (TTT, standard protocol Oosterhuis JA 1995), ruthenium brachytherapy (RB, tumor apex dose 150 Gy) or sandwich therapy (ST). One-step ST was defined as TTT followed by RB with 100 Gy tumor apex dose within 48 hours. The treatment of residual prominences with TTT secondary to RB after different time spans was called two-step ST. Follow-up was 2 years.


RESULTS
131 eyes with malignant choroidal melanoma (mean tumour thickness: 4.5 mm) were treated with RB (66 eyes), TTT (26 eyes) or ST (39 eyes). Preservation of the globe was achieved in 109 eyes (81 %). Local tumour control was found in small melanomas (prominence up to 3 mm) in 89 %, in large tumors (prominence 8 mm and higher) in 50 %. In a subgroup of small posterior melanomas (n = 70 eyes, prominence up to 4.5 mm, located posterior to the equator) local tumour control was noted in 91 %. The time span to reach local tumour control (Kaplan-Meier estimates) was the shortest after TTT (median: 20 weeks), compared with RB (48 weeks) and one-step ST (29 weeks).


CONCLUSIONS
In choroidal melanomas the chance of local tumour control and preservation of the globe decreases with increase of the tumour prominence. In small choroidal melanomas with posterior location local tumour control was achieved significantly faster after TTT than after RB.
Stoffelns
B M
BM
Augenklinik der Johannes-Gutenberg-Universität, Mainz, Deutschland. stoffelns@augen.klinik.unimainz.de
Schoepfer
K
K
Jochem
T
T
Faldum
A
A
D001918:Brachytherapy / Q000379:methods*; D002830:Choroid Neoplasms / Q000175:diagnosis / Q000628:therapy*; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007554:Isotopes / Q000627:therapeutic use; D008297:Male; D008545:Melanoma / Q000150:complications / Q000628:therapy*; D008875:Middle Aged; D011680:Pupil; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D012189:Retrospective Studies; D012428:Ruthenium / Q000627:therapeutic use*; D016896:Treatment Outcome
D007554:Isotopes; D019275:Radiopharmaceuticals; D012428:Ruthenium