title: Cyclometalated gold(III) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons.
abstract: A panel of stable [Au(R-C--N--C)(N-heterocyclic carbene)](+) complexes displays prominent in vitro anticancer properties; [Au(C--N--C)(IMe)]CF(3)SO(3) (1, IMe = 1,3-dimethylimidazol-2-ylidene) significantly poisons topoisomerase I in vitro and suppresses tumor growth in nude mice model.
authors.affiliation: Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, China.
authors.forename: Jessie Jing
authors.initials: JJ
authors.lastname: Yan
authors.forename: Andy Lok-Fung
authors.initials: AL
authors.lastname: Chow
authors.forename: Chung-Hang
authors.initials: CH
authors.lastname: Leung
authors.forename: Raymond Wai-Yin
authors.initials: RW
authors.lastname: Sun
authors.forename: Dik-Lung
authors.initials: DL
authors.lastname: Ma
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy; D003198:Computer Simulation; D056831:Coordination Complexes / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D004264:DNA Topoisomerases, Type I / Q000378:metabolism; D006046:Gold / Q000737:chemistry*; D056945:Hep G2 Cells; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006801:Humans; D008024:Ligands; D008113:Liver Neoplasms / Q000188:drug therapy; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D051379:Mice; D008819:Mice, Nude; D059004:Topoisomerase I Inhibitors
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D006571:Heterocyclic Compounds; D008024:Ligands; D059004:Topoisomerase I Inhibitors; C030011:carbene; D006046:Gold; D004264:DNA Topoisomerases, Type I; D008697:Methane