Microbial metabolism. Part 11. Metabolites of flutamide.
The yeast culture, Rhodotorula mucilaginosa (ATCC 20129) transformed flutamide (1) to three metabolites: 4-nitro-3-(trifluoromethyl)aniline (2), 2-methyl-N-[4-amino-3-(trifloromethyl)phenyl]propanamide (3) and N-[4-amino-3-(trifluoromethyl)phenyl]acetamide (4). The structures were established by spectroscopic methods.
Herath
Wimal
W
National Center for Natural Products Research, The University of Mississippi, University, MS 38677, USA.
Khan
Ikhlas Ahmad
IA
D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry / Q000378:metabolism*; D005485:Flutamide / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D015394:Molecular Structure; D012248:Rhodotorula / Q000737:chemistry / Q000378:metabolism*
D018931:Antineoplastic Agents, Hormonal; D005485:Flutamide