Modulation of neuroprotective effect of ischemic post-conditioning by dichlorobenzamil a Na(+)/Ca(2+) exchanger inhibitor in mice.
The present study has been designed to investigate the modulatory role of dichlorobenzamil a Na(+)/Ca(2+) exchanger inhibitor in ischemic post-conditioning-induced neuroprotection in mice. Bilateral carotid artery occlusion followed by reperfusion, produced a significant rise in cerebral infarct size along with impairment of memory and motor coordination. Ischemic post-conditioning involving three episodes of 10 s carotid artery occlusion with intermittent reperfusion of 10 s proceeding prolonged ischemic insult of 12 min, produced a significant decrease in cerebral infarct size along with reversal of ischemia-reperfusion-induced impairment of memory and motor coordination. Ischemic post-conditioning-induced neuroprotective effects were significantly abolished by pretreatment with dichlorobenzamil (DBZ 0.5, 1 mg/kg, intraperitoneal) a Na(+)/Ca(2+) exchange inhibitor. It may be concluded that Na(+)/Ca(2+) exchanger possibly plays an important role in ischemic post-conditioning-induced neuroprotection.
Kaur
Hardeep
H
Department of Pharmaceutical Sciences and Drug Research, Punjabi University, India.
Jaggi
Amteshwar Singh
AS
Singh
Nirmal
N
D000584:Amiloride / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D002118:Calcium; D002339:Carotid Arteries; D002544:Cerebral Infarction / Q000150:complications / Q000188:drug therapy*; D003072:Cognition Disorders / Q000188:drug therapy* / Q000209:etiology; D019194:Ischemic Preconditioning; D008297:Male; D008568:Memory / Q000187:drug effects; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D011597:Psychomotor Performance / Q000187:drug effects; D015427:Reperfusion Injury / Q000188:drug therapy*; D012964:Sodium; D026941:Sodium Channel Blockers / Q000494:pharmacology / Q000627:therapeutic use; D019831:Sodium-Calcium Exchanger / Q000037:antagonists & inhibitors*; D020521:Stroke / Q000188:drug therapy
D018696:Neuroprotective Agents; D026941:Sodium Channel Blockers; D019831:Sodium-Calcium Exchanger; C041470:3',4'-dichlorobenzamil; D000584:Amiloride; D012964:Sodium; D002118:Calcium