title: Biological potentials and cytotoxicity of various extracts from endemic Origanum minutiflorum O. Schwarz & P.H. Davis.
abstract: The aim of the present study was to investigate antioxidative, antimicrobial and cytotoxic effects of endemic Origanum minutiflorum (O. Schwarz & P.H. Davis). Antioxidant activities of the extracts from O. minutiflorum were evaluated by using DPPH radical scavenging, beta-carotene bleaching and metal chelating activity assays. In addition, the amounts of total phenol components in the plant extracts were determined. In the beta-carotene bleaching test, the extracts exhibited in the range of 58.1+/-0.2% - 98.2+/-0.3% inhibition against linoleic acid oxidation. The antimicrobial efficiency of the plant was evaluated according to agar well diffusion and microdilution broth methods. The n-hexane extract of O. minutiflorum having an inhibition zone of 20.2+/-0.2 mm, had the maximum antibacterial efficiency against Shigella sonnei RSKK 878. Cytotoxic effects of the extracts were determined by MTT assay. O. minutiflorum extracts (at concentration of 10-100 microg/ml) did not show any cytotoxic effect on baby hamster kidney fibroblast cell line. The results showed that O. minutiflorum could be used as a natural source in food industry.
authors.affiliation: Department of Biology, Faculty of Art and Science, Gazi University, Ankara, Turkey. feyzaoke@gazi.edu.tr
authors.forename: Feyza
authors.initials: F
authors.lastname: Oke
authors.forename: Belma
authors.initials: B
authors.lastname: Aslim
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D006224:Cricetinae; D031341:Origanum / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts