Innate and adaptive factors regulating human immunodeficiency virus type 1 genomic activation.
Over the past decade, antiretroviral therapy targeting the viral entry process, reverse transcriptase, integrase, and protease, has prolonged the lives of people infected with human immunodeficiency virus type 1 (HIV-1). However, despite the development of more effective therapeutic strategies, reservoirs of viral infection remain. This review discusses molecular mechanisms surrounding the development of latency from the site of integration to pre- and post-integration maintenance of latency, including epigenetic factors. In addition, an overview of innate and adaptive cells important to HIV-1 infection are examined from the viewpoint of cytokines released and cytokines that act on these cells to explore an overall understanding of HIV-1 proviral genome activation. Finally, this review is discussed from the viewpoint of how an understanding of the interplay of all of these factors will help guide the next generation of therapies.
Shah
Sonia
S
Department of Microbiology and Immunology, Drexel University College of Medicine, 2900 Queen Lane, Philadelphia, PA 19129, USA.
Nonnemacher
Michael R
MR
Pirrone
Vanessa
V
Wigdahl
Brian
B
D019380:Anti-HIV Agents / Q000627:therapeutic use; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines; D044127:Epigenesis, Genetic / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology / Q000821:virology; D016325:HIV Long Terminal Repeat / Q000502:physiology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D014775:Virus Activation / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D016662:Virus Integration / Q000187:drug effects / Q000502:physiology; D017735:Virus Latency / Q000276:immunology / Q000502:physiology
D019380:Anti-HIV Agents; D016207:Cytokines
Cell. 2002 Aug 23;110(4):521-9
12202041
PLoS Pathog. 2008 Dec;4(12):e1000215
19112504
Nucleic Acids Res. 1993 Dec 11;21(24):5786-93
8284230
Curr Top Med Chem. 2009;9(3):257-71
19355990
Genes Dev. 1996 Jan 1;10(1):37-49
8557193
J Clin Immunol. 2001 May;21(3):218-26
11403229
J Virol. 2003 Nov;77(21):11531-5
14557638
J Intern Med. 2009 Jan;265(1):29-42
19093958
Mol Cell Biol. 2002 May;22(9):2965-73
11940654
Nature. 2002 Jul 25;418(6896):435-8
12087358
J Virol. 1996 Oct;70(10):7013-29
8794346
Nature. 2002 Aug 8;418(6898):646-50
12167863
Virology. 2000 Sep 1;274(2):262-77
10964770
J Immunol. 1997 Jan 1;158(1):5-8
8977168
Nat Immunol. 2003 Jul;4(7):607-15
12830135
Glia. 1993 Jan;7(1):19-24
7678581
Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10548-55
8855215
Science. 1997 Nov 14;278(5341):1291-5
9360926
Trends Mol Med. 2004 Nov;10(11):525-31
15519278
Proc Natl Acad Sci U S A. 1997 Aug 5;94(16):8714-9
9238043
J Biol Chem. 2001 Sep 21;276(38):35435-43
11457829
J Biomed Sci. 1997 Jan-Feb;4(1):39-46
11725132
Science. 1991 Oct 18;254(5030):423-7
1925601
Cell. 1990 Apr 20;61(2):213-22
2331748
Mol Cell. 2001 Aug;8(2):327-37
11545735
Nature. 1995 Jan 12;373(6510):123-6
7816094
EMBO J. 1990 Dec;9(13):4417-23
2124973
Nat Med. 2003 Nov;9(11):1404-7
14528300
Virology. 1985 Nov;147(1):231-6
2998068
Neurology. 1994 Mar;44(3 Pt 1):481-7
8145919
J Biol Chem. 2004 Dec 3;279(49):51545-53
15452123
J Biol Chem. 2006 May 5;281(18):12495-505
16540471
J Neuroimmunol. 2004 Dec;157(1-2):39-47
15579278
Brain Pathol. 2003 Apr;13(2):144-54
12744468
Genome Res. 2007 Aug;17(8):1186-94
17545577
J Virol. 2007 Jun;81(11):6043-56
17376917
N Engl J Med. 1998 Mar 26;338(13):853-60
9516219
Ann Intern Med. 1993 May 1;118(9):681-8
8096374
Mol Ther. 2008 Mar;16(3):565-70
18227841
AIDS Res Hum Retroviruses. 2009 Sep;25(9):883-7
19689202
J Virol. 2000 Dec;74(23):11191-200
11070016
Am J Pathol. 2004 Jun;164(6):2089-99
15161643
PLoS Pathog. 2009 Jun;5(6):e1000495
19557157
Microb Pathog. 1986 Feb;1(1):1-4
2854593
Cell. 2005 Jul 29;122(2):169-82
16051143
J RNAi Gene Silencing. 2005 Oct 11;1(2):66-78
19771207
Science. 2003 Jan 31;299(5607):719-21
12560554
Microbes Infect. 2009 Apr;11(4):500-8
19233310
J Clin Invest. 1986 May;77(5):1712-5
2422213
PLoS Pathog. 2006 Jun;2(6):e60
16789841
Proc Natl Acad Sci U S A. 1989 Jan;86(2):675-9
2492110
EMBO J. 2003 Apr 15;22(8):1868-77
12682019
Retrovirology. 2009 Jun 01;6:51
19486514
Curr HIV Res. 2008 Sep;6(5):388-400
18855649
J Immunol. 1986 Jul 1;137(1):323-9
3011909
J Exp Med. 1990 Jul 1;172(1):151-8
2193094
Virology. 2006 Jul 5;350(2):443-52
16542695
PLoS One. 2007 Dec 19;2(12):e1340
18092005
J Infect Dis. 2008 Feb 1;197(3):411-9
18248304
J Virol. 1992 Mar;66(3):1321-8
1738192
J Immunol. 2005 Mar 15;174(6):3534-44
15749890
J Exp Med. 2001 Apr 16;193(8):905-15
11304551
Cell. 1993 Oct 8;75(1):5-8
8402900
AIDS. 2009 Sep 24;23(15):1987-95
19696651
Proc Natl Acad Sci U S A. 1989 Nov;86(21):8575-9
2813413
AIDS. 2002 Jul 26;16(11):1479-87
12131185
Proc Natl Acad Sci U S A. 1986 Sep;83(18):7089-93
3018755
J Virol. 2000 Aug;74(15):6790-9
10888618
J Exp Med. 1992 Sep 1;176(3):739-50
1512539
Virology. 2001 Oct 25;289(2):312-26
11689053
J Virol. 1995 Sep;69(9):5337-44
7636977
J Neurovirol. 2001 Jun;7(3):235-49
11517398
Trends Biochem Sci. 2006 Feb;31(2):98-105
16403635
Retrovirology. 2006 Jan 16;3:7
16412247
J Biol Chem. 2008 Aug 22;283(34):23353-63
18519571
AIDS. 2009 Jul 31;23(12):1461-71
19550285
Eur J Haematol. 2009 Jun;82(6):440-9
19220424
Curr HIV/AIDS Rep. 2008 Feb;5(1):27-32
18417032
Proc Natl Acad Sci U S A. 1995 Nov 21;92(24):10985-9
7479922
Genetica. 1999;106(1-2):125-30
10710718
Retrovirology. 2009 Jul 13;6:63
19594910
Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7298-302
8346247
Mol Cell. 2003 Jul;12(1):167-76
12887902
Mol Cell Biol. 2006 Jan;26(2):457-71
16382138
J Virol. 1999 Aug;73(8):6526-32
10400748
Biomed Pharmacother. 2003 Jan;57(1):41-8
12642036
J Virol. 2005 Sep;79(18):12035-44
16140779
Science. 1988 Nov 11;242(4880):919-22
2460922
Nat Med. 2003 Jun;9(6):727-8
12754504
J Virol. 1991 Dec;65(12):6790-9
1942252
J Virol. 1989 Oct;63(10):4404-8
2789293
J Exp Med. 2006 Jan 23;203(1):41-6
16418394
Lancet. 2005 Aug 13-19;366(9485):549-55
16099290
Res Virol. 1991 Mar-Jun;142(2-3):197-204
1716776
Cell. 1991 Dec 20;67(6):1211-21
1760846
J Neuropathol Exp Neurol. 1992 May;51(3):246-56
1583531
Science. 1997 Nov 14;278(5341):1295-300
9360927
BMC Infect Dis. 2009 Oct 19;9:172
19840392
Science. 1997 Jan 24;275(5299):523-7
8999795
Science. 1990 Aug 3;249(4968):549-53
2200125
Eur Cytokine Netw. 2000 Mar;11(1):47-52
10705298
Nature. 1997 May 8;387(6629):183-8
9144289
Cell. 1997 Feb 21;88(4):483-92
9038339
J Biol Chem. 2004 Aug 13;279(33):34083-6
15215254
J Neuropathol Exp Neurol. 1999 Nov;58(11):1156-62
10560658
J Virol. 1995 May;69(5):2765-75
7707499
Gene. 1998 Jun 8;212(2):157-66
9611258
J Virol. 1996 May;70(5):3098-107
8627789
J Clin Invest. 2005 Jan;115(1):128-37
15630452
J Virol. 1994 Apr;68(4):2598-604
7511175
Genes Dev. 2003 Nov 1;17(21):2648-63
14563679
Cell. 1990 Aug 24;62(4):757-67
2201451
J Infect Dis. 2007 Mar 15;195(6):833-6
17299713
Virus Res. 2005 Aug;111(2):194-213
15885841
J Virol. 1999 Aug;73(8):7008-13
10400800
J Virol. 2007 Oct;81(20):10914-23
17670825
Nat Rev Microbiol. 2007 Feb;5(2):95-106
17224919
J Virol. 1992 Jan;66(1):139-49
1727476
J Virol. 2001 Feb;75(4):1842-56
11160683
Cell. 1994 Apr 8;77(1):13-6
8156588
J Virol. 2000 Jul;74(13):5982-7
10846079
J Virol. 1997 Jul;71(7):5382-90
9188609
Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13519-24
9811832
J Virol. 1997 Aug;71(8):6113-27
9223506
PLoS Comput Biol. 2006 Nov 24;2(11):e157
17166054
J Virol. 2002 Sep;76(17):8518-31
12163571
J Virol. 2002 Sep;76(18):9225-31
12186906
Virology. 1992 Sep;190(1):19-29
1529528
J Virol. 2006 Aug;80(15):7645-57
16840343
PLoS Pathog. 2009 Jan;5(1):e1000260
19132086
DNA Cell Biol. 2004 Apr;23(4):261-9
15142383
AIDS. 1992 Mar;6(3):273-85
1373627
J Gen Virol. 2007 Feb;88(Pt 2):641-651
17251583
Science. 1995 Jan 27;267(5197):483-9
7824947
EMBO J. 1997 May 1;16(9):2463-72
9171359
J Virol. 1989 Nov;63(11):4919-24
2795721
Ann Neurol. 1996 Jun;39(6):705-11
8651642
EMBO J. 2006 Jan 11;25(1):139-49
16319923
AIDS. 2008 Jan 2;22(1):39-45
18090390
J Neurovirol. 2003 Feb;9(1):55-68
12587069
Nat Med. 1995 Dec;1(12):1284-90
7489410
Blood. 2007 Jul 1;110(1):393-400
17371941
Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6580-4
1631159
J Clin Immunol. 1998 Mar;18(2):124-31
9533656
J Leukoc Biol. 1994 Sep;56(3):273-7
8083599
AIDS. 1999 Dec 3;13(17):2405-10
10597782
Nat Med. 1999 May;5(5):512-7
10229227
EMBO J. 1993 Aug;12(8):3249-59
8344262
Annu Rev Biochem. 1994;63:717-43
7979253
AIDS. 2000 Apr 14;14(6):659-69
10807189
J Virol. 2009 Apr;83(8):3518-27
19211771
Nat Med. 1998 Dec;4(12):1397-400
9846577
AIDS. 1993 Aug;7(8):1035-40
8104421
EMBO J. 1999 Nov 1;18(21):6106-18
10545121
Virus Res. 1998 Sep;57(1):11-20
9833881
Gene. 1993 Dec 22;136(1-2):341-3
8294028
EMBO J. 1996 Mar 1;15(5):1112-20
8605881
Nat Med. 1999 Jun;5(6):651-5
10371503
EMBO J. 2001 Apr 2;20(7):1726-38
11285236
EMBO J. 2007 Dec 12;26(24):4985-95
18007589
Mol Med. 1995 Sep;1(6):667-77
8529133
Science. 2003 Jun 13;300(5626):1749-51
12805549
Immunity. 1996 Jul;5(1):91-101
8758898
Neurology. 1992 Sep;42(9):1736-9
1513462
J Neurovirol. 2004;10 Suppl 1:7-14
14982733
EMBO J. 2006 Aug 9;25(15):3596-604
16874302
Virology. 1992 Jun;188(2):451-8
1585628
J Leukoc Biol. 2008 Dec;84(6):1447-53
18806124
J Immunol. 1988 Feb 15;140(4):1117-22
2449497
Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2927-32
9096323
J Virol. 2005 Jun;79(11):6610-9
15890899
Methods. 2009 Apr;47(4):254-60
19195495
J Neurovirol. 2004;10 Suppl 1:25-32
14982736
Nat Rev Microbiol. 2005 Nov;3(11):848-58
16175173
J Virol. 1991 Aug;65(8):4350-8
2072454
EMBO J. 2005 Sep 7;24(17):3070-81
16096645
J Virol. 2005 Feb;79(4):2199-210
15681422
Brain Pathol. 2002 Oct;12(4):442-55
12408230
J Virol. 1993 Dec;67(12):7450-60
8230466
PLoS Biol. 2004 Aug;2(8):E234
15314653
Radiol Technol. 2008 Jan-Feb;79(3):243-52; quiz 253-5
18203878
J Virol. 2003 Apr;77(7):4025-32
12634362
Cell. 1996 Mar 22;84(6):817-9
8601304
Virology. 2004 Aug 1;325(2):328-39
15246272
AIDS. 2009 Sep 10;23(14):1799-806
19590405
Proc Natl Acad Sci U S A. 1998 Oct 13;95(21):12550-5
9770523
J Clin Invest. 1998 Jul 1;102(1):223-31
9649576