title: Association of genotoxic effects of arsenic with haematological malignancy in West Bengal.
abstract: Arsenic is a naturally occurring metalloid that has been associated with increased incidence of human cancers in certain highly exposed populations. This present work aimed to study whether arsenic plays any role in the increased incidence of blood cancer among residents of West Bengal, India, which is one of the worst arsenic-affected areas of the world. Our study group included both blood cancer patients and age-, sex-matched healthy controls. We studied the arsenic concentration in the hair and nail samples of our study group. We found significantly higher arsenic concentration in the biological tissues of patients, which also correlated with their greater incidence of chromosomal aberrations. Thus, arsenic may act as a predisposing factor for blood cancer.
authors.affiliation: Department of Genetics, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratisthan, Kolkata 700026, India. sonalismail@rediffmail.com
authors.forename: Sonali
authors.initials: S
authors.lastname: Paul
authors.forename: Tulika
authors.initials: T
authors.lastname: Chakraborty
authors.forename: Ajanta
authors.initials: A
authors.lastname: Halder
authors.forename: Debasis
authors.initials: D
authors.lastname: Bandopadhyay
authors.forename: Utpal
authors.initials: U
authors.lastname: Chaudhuri
authors.forename: Madhusnata
authors.initials: M
authors.lastname: De
mesh_terms: D000293:Adolescent; D000328:Adult; D001151:Arsenic / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D002648:Child; D002869:Chromosome Aberrations / Q000139:chemically induced*; D005260:Female; D006197:Hair / Q000737:chemistry; D019337:Hematologic Neoplasms / Q000139:chemically induced* / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009153:Mutagens / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D009262:Nails / Q000737:chemistry; D012189:Retrospective Studies; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D055815:Young Adult
chemical_list: D009153:Mutagens; D014874:Water Pollutants, Chemical; D001151:Arsenic