title: The novel swine-origin H1N1 influenza A virus riddle: is it a domestic bird H1N1-derived virus?
abstract: To understand the role of domestic birds in the 2009 H1N1 influenza A outbreak, a phylogenetic analysis of hemagglutinin, neuraminidase and matrix protein genes from human, avian and swine H1N1 viruses was carried out. Analysis of the H1 sequences revealed that the virus evolved most likely from American swine as well as intermixing between Asian swine and American domestic bird H1N1 viruses. Neuroaminidase and matrix protein analysis showed that the H1N1 2009 viruses were more closely related to the H1N1 isolates from Euro-Asiatic domestic birds and swine than wild birds. Domestic birds could act as intermediate hosts of H1N1 reassortants.
authors.affiliation: Laboratory of Molecular Virology, Foundation University Hospital Tor Vergata, Rome, Italy.
authors.forename: Muhammed
authors.initials: M
authors.lastname: Babakir-Mina
authors.forename: Salvatore
authors.initials: S
authors.lastname: Dimonte
authors.forename: Massimo
authors.initials: M
authors.lastname: Ciccozzi
authors.forename: Carlo Federico
authors.initials: CF
authors.lastname: Perno
authors.forename: Marco
authors.initials: M
authors.lastname: Ciotti
mesh_terms: D000818:Animals; D001717:Birds; D019143:Evolution, Molecular; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000145:classification / Q000201:enzymology / Q000235:genetics* / Q000302:isolation & purification*; D005585:Influenza in Birds / Q000821:virology*; D007251:Influenza, Human / Q000821:virology*; D008969:Molecular Sequence Data; D009439:Neuraminidase / Q000235:genetics; D009976:Orthomyxoviridae Infections / Q000662:veterinary* / Q000821:virology; D010802:Phylogeny; D016865:Reassortant Viruses / Q000145:classification / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification; D013552:Swine; D013553:Swine Diseases / Q000821:virology*; D014763:Viral Matrix Proteins / Q000235:genetics
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus; C488936:M1 protein, Influenza A virus; D014763:Viral Matrix Proteins; D009439:Neuraminidase