[Kallikrein-kinin system parameters as markers of various adaptive capacities of the body in young male patients with mitral valve prolapse].
The activity of kinin system parameters was studied in 137 young male patients with mitral valve prolapse (MVP) in relation to the body's adaptive capacities. As compared with the controls, the patients with high (Group 1) and low (Group 2) adaptive capacities showed 57.08 and 79.14% increases in leukocyte elastase activity, respectively (p < 0.05). In Groups 1 and 2, the leukocyte elastase/alpha1-proteinase inhibitor ratio was 55.6% and by 2.16-fold higher, respectively, than in the controls (p < 0.05). Thus, the high the leukocyte elastase/alpha1-proteinase inhibitor ratio may serve as a biochemical marker of diminished adaptive capacities in young male patients with mitral valve prolapse and indicate a poor prognosis associated with degradation of a diversity of functionally significant proteins.
Chepurnenko
S A
SA
D000222:Adaptation, Physiological; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D006801:Humans; D007610:Kallikreins / Q000097:blood*; D007705:Kinins / Q000097:blood*; D019272:Leukocyte Elastase / Q000097:blood; D008297:Male; D008945:Mitral Valve Prolapse / Q000097:blood*; D055815:Young Adult; D000515:alpha 1-Antitrypsin / Q000097:blood
D015415:Biomarkers; D007705:Kinins; D000515:alpha 1-Antitrypsin; D007610:Kallikreins; D019272:Leukocyte Elastase