title: Magnesium sulfate infusion prevents shivering during transurethral prostatectomy with spinal anesthesia: a randomized, double-blinded, controlled study.
abstract: OBJECTIVE
  To determine whether magnesium sulfate (MgSO(4)) infusion during surgery reduces shivering during spinal anesthesia.
  
  
  METHODS
  Double-blinded placebo-controlled, randomized trial.
  
  
  METHODS
  Operation room of a university hospital.
  
  
  METHODS
  60 patients, aged 40 to 70 years, scheduled for elective transurethral resection of the prostate (TURP) during spinal anesthesia.
  
  
  METHODS
  Subarachnoid anesthesia consisting of hyperbaric bupivacaine three mL 0.5% was injected using a 25-G Quincke spinal needle. Patients received either saline (Group C, n = 30) or MgSO(4) (Group Mg, n = 30). Group Mg received an intravenous (IV) bolus of MgSO(4) 80 mg/kg via syringe pump over a 30-minute period, followed by a two g/hr infusion during the intraoperative period. Group C received an equal volume of saline.
  
  
  METHODS
  Motor blockade was evaluated by Bromage motor scale. Sensory block level was assessed by pinprick test. Shivering was assessed after the completion of subarachnoid drug injection. Side effects were recorded.
  
  
  RESULTS
  Hypothermia was observed in all patients (100%) in Group Mg and in 24 patients (80%) in Group C (P = 0.024). The decrease in core temperature in Group Mg was significantly greater (P < 0.005). Shivering was observed in two patients (6.7%) in Group Mg and 20 patients (66.7%) in Group C (P = 0.0001).
  
  
  CONCLUSIONS
  MgSO(4) infusion in the perioperative period significantly reduced shivering during TURP with spinal anesthesia. MgSO(4) infusion prevents shivering in patients receiving spinal anesthesia but increases the risk of hypothermia.
authors.affiliation: Department of Anesthesiology and Reanimation, Fatih University School of Medicine, Ankara 06540, Turkey. doktormuhammet@yahoo.com
authors.forename: Muhammet
authors.initials: M
authors.lastname: Gozdemir
authors.forename: Burhanettin
authors.initials: B
authors.lastname: Usta
authors.forename: Ruveyda Irem
authors.initials: RI
authors.lastname: Demircioglu
authors.forename: Bunyamin
authors.initials: B
authors.lastname: Muslu
authors.forename: Huseyin
authors.initials: H
authors.lastname: Sert
authors.forename: Omer Faruk
authors.initials: OF
authors.lastname: Karatas
mesh_terms: D000328:Adult; D000368:Aged; D000775:Anesthesia, Spinal / Q000379:methods*; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects; D004311:Double-Blind Method; D006801:Humans; D007262:Infusions, Intravenous; D008278:Magnesium Sulfate / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D012768:Shivering / Q000187:drug effects*; D020728:Transurethral Resection of Prostate
chemical_list: D000927:Anticonvulsants; D008278:Magnesium Sulfate