[Effect of delta-sleep inducing peptide preparation Deltaran on longevity, physiological functions, and carcinogenesis in mice].
Female SHR mice received 5-days long monthly courses of delta-sleep inducing peptide (DSIP) preparation "Deltaran" subcutaneously in dose 5 mkg/kg during all their lives. It was demonstrated, that last 10% (most aged) of mice which received Deltaran lived for 16% longer than the controls. They had significantly higher amount of vertical activity in the "open field" test, than the controls, starting from time when they were 6 months old and until their natural death. Mice of Deltaran group spent 73% more time in the open arms of elevated plus maze, and 9 times more often explored the extremities of this maze, than controls. Also Deltaran slowed the spontaneous carcinogenesis parameters. It's assumed that DSIP preparation "Deltaran" have geroprotective, anxiolytic and antitumor activity.
Voĭtenkov
V B
VB
Popovich
I G
IG
Zabezhinskiĭ
M A
MA
Iurova
M A
MA
Piskunova
T A
TA
Mikhaleva
I I
II
D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015415:Biomarkers / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D003701:Delta Sleep-Inducing Peptide / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004338:Drug Combinations; D005221:Fatigue / Q000517:prevention & control; D005260:Female; D005998:Glycine / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D008136:Longevity / Q000187:drug effects* / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects; D053580:Muscle Strength / Q000187:drug effects; D009369:Neoplasms / Q000517:prevention & control*
D000975:Antioxidants; D015415:Biomarkers; D004338:Drug Combinations; C515717:deltaran; D003701:Delta Sleep-Inducing Peptide; D005998:Glycine