Synthesis and preliminary biological screening of sterol analogues as new antifungal agents against plant pathogens.
In this paper we report the synthesis of a new family of sterol analogues that have two amidic bonds on the side chain. These azasterols were obtained by a straightforward procedure including an Ugi condensation that allows the facile attachment of a polyfunctionalized side chain into the steroidal framework. Some of the new compounds showed an interesting inhibitory effect on the growth of two pathogenic fungi involved in plant diseases.
Alonso
Fernando
F
Departamento de Química Orgánica and UMYMFOR (CONICET - Facultad de Ciencias Exactas y Naturales), Universidad de Buenos Aires, Pabellón 2, Piso 3, Ciudad Universitaria, C1428EGA Buenos Aires, Argentina.
Cirigliano
Adriana M
AM
Cabrera
Gabriela M
GM
Ramírez
Javier A
JA
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001378:Azasteroids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D005670:Fusarium / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
D000935:Antifungal Agents; D001378:Azasteroids