title: Quantification of hepatic iron deposition in patients with liver disease: comparison of chemical shift imaging with single-echo T2*-weighted imaging.
abstract: OBJECTIVE
  The purpose of this study was to determine the diagnostic performance of chemical shift imaging, compared with that of single-echo T2*-weighted imaging, for hepatic iron quantification in patients with liver disease, and to examine the confounding effect of steatosis.
  
  
  METHODS
  Sixty-three patients who underwent liver MRI and who had concomitant liver histopathologic analysis were retrospectively assessed. Chemical shift imaging and T2*-weighted imaging (n = 49) of the liver were reviewed by two independent observers. An iron index for each sequence (I(Fe-CSI) and I(Fe-T2*), respectively) was correlated with pathologic iron grade (0-4). Receiver operating characteristic curve analysis was performed to assess the accuracy of both sequences for the diagnosis of iron deposition (grades >or= 1, >or= 2, and >or= 3), and the impact of steatosis on accuracy was evaluated.
  
  
  RESULTS
  Forty-seven (74.6%) patients had hepatic siderosis. There was a significant correlation between both I(Fe-CSI) and I(Fe-T2*) with pathologic iron grade (r = 0.65 and -0.61, respectively; p < 0.0001 for both). I(Fe-CSI) and I(Fe-T2*) were significantly higher or lower in iron grades 2-4 versus grades 0-1 and in grades 3-4 versus grades 0-2 (p < 0.001). Area under the curve values for detecting iron grade >or= 1, >or= 2, and >or= 3 were 0.75, 0.88, and 0.90 for I(Fe-CSI) and 0.72, 0.81, and 0.98 for I(Fe-T2*). Accuracy was lower for both sequences in steatotic patients for detection of iron grades >or= 1 and >or= 2, without reaching significance.
  
  
  CONCLUSIONS
  Routine chemical shift imaging and single-echo T2*-weighted imaging have excellent diagnostic performance for detection of significant hepatic siderosis (grade >or= 2). Concomitant steatosis lowers the diagnostic performance of both sequences without reaching significance.
authors.affiliation: Department of Radiology, New York University Langone Medical Center, New York, NY, USA.
authors.forename: Ruth P
authors.initials: RP
authors.lastname: Lim
authors.forename: Keren
authors.initials: K
authors.lastname: Tuvia
authors.forename: Cristina H
authors.initials: CH
authors.lastname: Hajdu
authors.forename: Mariela
authors.initials: M
authors.lastname: Losada
authors.forename: Raavi
authors.initials: R
authors.lastname: Gupta
authors.forename: Tejas
authors.initials: T
authors.lastname: Parikh
authors.forename: James S
authors.initials: JS
authors.lastname: Babb
authors.forename: Bachir
authors.initials: B
authors.lastname: Taouli
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D017352:Echo-Planar Imaging / Q000379:methods*; D005234:Fatty Liver / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*; D005260:Female; D006801:Humans; D007501:Iron / Q000032:analysis*; D019190:Iron Overload / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007501:Iron