title: Functional evaluation of hidden figures object analysis in children with autistic disorder.
abstract: Functional magnetic resonance imaging (fMRI) during performance of a hidden figures task (HFT) was used to compare differences in brain function in children diagnosed with autism disorder (AD) compared to children with attention-deficit/hyperactivity disorder (ADHD) and typical controls (TC). Overall greater functional MRI activity was observed in the two control groups compared to children with AD. Laterality differences were also evident, with AD subjects preferentially showing activity in the right medial temporal region while controls tended to activate the left medial temporal cortex. Reduced fMRI activity was observed in the parietal, ventral-temporal and hippocampal regions in the AD group, suggesting differences in the way that children with AD process the HFT.
authors.affiliation: National Research Council, Institute for Biodiagnostics, 435 Ellice Avenue, Winnipeg, MB, R3B 1Y6, Canada. Kris.Malisza@nrc-cnrc.gc.ca
authors.forename: Krisztina L
authors.initials: KL
authors.lastname: Malisza
authors.forename: Christine
authors.initials: C
authors.lastname: Clancy
authors.forename: Deborah
authors.initials: D
authors.lastname: Shiloff
authors.forename: Derek
authors.initials: D
authors.lastname: Foreman
authors.forename: Jeanette
authors.initials: J
authors.lastname: Holden
authors.forename: Cheryl
authors.initials: C
authors.lastname: Jones
authors.forename: K
authors.initials: K
authors.lastname: Paulson
authors.forename: Randy
authors.initials: R
authors.lastname: Summers
authors.forename: C T
authors.initials: CT
authors.lastname: Yu
authors.forename: Albert E
authors.initials: AE
authors.lastname: Chudley
mesh_terms: D000293:Adolescent; D001288:Attention / Q000502:physiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology; D001321:Autistic Disorder / Q000503:physiopathology*; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D002648:Child; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000502:physiology; D014796:Visual Perception / Q000502:physiology*
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