Morbid obesity and sleeve gastrectomy: how does it work?
Laparoscopic sleeve gastrectomy is known to be a safe and effective procedure for treating morbid obesity and is performed with increasing frequency both in Europe and the USA. Despite its broad use, many questions about the remaining gastric tube diameter, its long-term efficacy, its effects on gastric emptying, and the hormones involved still remain to be answered. In order to use such a relatively new surgical procedure wisely, it is essential for every surgeon and physician to understand how sleeve gastrectomy acts in obesity and what its potential benefits on the patients' metabolism are. This review focuses on the most important pathophysiologic questions referred to sleeve gastrectomy on the literature so far, in an attempt to evaluate the different issues still pending on the subject.
Papailiou
Joanna
J
1st Department of Propaedeutic Surgery, Hippocration Hospital, Athens Medical School, 114 Vas. Sofias Ave, 11527, Athens, Greece.
Albanopoulos
Konstantinos
K
Toutouzas
Konstantinos G
KG
Tsigris
Christos
C
Nikiteas
Nikolaos
N
Zografos
George
G
D001066:Appetite / Q000502:physiology; D005743:Gastrectomy / Q000379:methods*; D005746:Gastric Emptying / Q000502:physiology; D054439:Ghrelin / Q000502:physiology; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D020738:Leptin / Q000502:physiology; D009767:Obesity, Morbid / Q000503:physiopathology / Q000601:surgery*; D019894:Peptide YY / Q000502:physiology; D011312:Pressure; D012528:Satiety Response / Q000502:physiology; D013270:Stomach / Q000503:physiopathology
D054439:Ghrelin; D020738:Leptin; D019894:Peptide YY
Obes Surg. 2009 Mar;19(3):327-31
18975038
Surg Endosc. 2010 Apr;24(4):781-5
19690918
Curr Diabetes Rev. 2008 Feb;4(1):18-23
18220691
N Engl J Med. 2002 May 23;346(21):1623-30
12023994
N Engl J Med. 2003 Sep 4;349(10):941-8
12954742
Obes Surg. 2007 Jul;17(7):853-5
17894140
Obes Surg. 2008 Jan;18(1):97-108
18066699
Ann Surg. 2008 Mar;247(3):401-7
18376181
J Clin Endocrinol Metab. 2001 Dec;86(12):5992
11739476
Ann Surg. 2006 Jan;243(1):108-14
16371744
Obes Surg. 2005 May;15(5):612-7
15946449
Biochem Soc Trans. 2006 Nov;34(Pt 5):774-8
17052195
Neuropeptides. 2006 Oct;40(5):317-24
17045646
Peptides. 2007 Jun;28(6):1185-90
17475366
Gastroenterology. 2001 Feb;120(2):337-45
11159873
Arch Surg. 2004 Jul;139(7):780-4
15249413
J Clin Endocrinol Metab. 2002 Jan;87(1):240-4
11788653
Clin Endocrinol (Oxf). 2002 Feb;56(2):203-6
11874411
Surg Today. 2007;37(4):275-81
17387557
Endocrinology. 2002 Jan;143(1):185-90
11751608
Chem Biol. 2006 Dec;13(12):1297-305
17185225
Obes Surg. 2006 Nov;16(11):1450-6
17132410
Obes Surg. 2009 Mar;19(3):357-62
18841429
Surg Obes Relat Dis. 2007 Nov-Dec;3(6):573-6
18023813
Obes Surg. 2007 Oct;17(10):1297-305
18098398
Peptides. 1996;17(2):305-11
8801538
Surg Obes Relat Dis. 2009 Jul-Aug;5(4):476-85
19632647
Nat Neurosci. 2005 May;8(5):571-8
15856065
Am J Physiol Regul Integr Comp Physiol. 2001 May;280(5):R1483-7
11294772
Clinics (Sao Paulo). 2009;64(11):1093-8
19936183
J Clin Invest. 1998 Feb 1;101(3):515-20
9449682
Surg Obes Relat Dis. 2008 Jul-Aug;4(4):528-33
18656834
Obes Surg. 2005 Sep;15(8):1124-8
16197783
Obes Surg. 2008 Sep;18(9):1083-8
18535864
Am J Physiol. 1993 Oct;265(4 Pt 2):R872-6
8238459
Clin Cancer Res. 2003 Feb;9(2):774-8
12576449
J Clin Endocrinol Metab. 2003 Feb;88(2):850-2
12574223
Surg Endosc. 2009 Apr;23(4):884
19118417
Obes Surg. 2006 Nov;16(11):1535-8
17132421
Diabetes. 2001 Apr;50(4):707-9
11289032
Obes Surg. 2007 Jan;17(1):57-62
17355769
Obes Surg. 2005 Aug;15(7):1024-9
16105401
Gastroenterology. 2002 Oct;123(4):1120-8
12360474
Obes Surg. 2006 Sep;16(9):1189-97
16989703
Obes Surg. 2010 Feb;20(2):140-7
19949885
Nature. 2000 Apr 6;404(6778):661-71
10766253
Obes Surg. 2009 Mar;19(3):293-8
19089519
Obes Surg. 2008 Sep;18(9):1077-82
18521701
Obes Surg. 2010 Jan;20(1):50-5
19916040
Diabetes. 2001 Aug;50(8):1714-9
11473029
Obes Surg. 2008 Oct;18(10):1323-9
18535867
Endocrinology. 2007 May;148(5):2251-63
17303662
Obes Surg. 2005 Nov-Dec;15(10):1469-75
16354529
Endocrinology. 2000 Nov;141(11):4325-8
11089570
Int J Obes Relat Metab Disord. 2000 Jul;24(7):899-905
10918538
Endocrinology. 2001 Oct;142(10):4163-9
11564668
J Clin Endocrinol Metab. 2003 Jan;88(1):109-16
12519838
Obes Surg. 2009 Apr;19(4):495-9
19169764
Obes Surg. 2003 Aug;13(4):649-54
12935370
Int J Obes. 1981;5(5):471-80
6796532
Obes Surg. 2006 Feb;16(2):166-71
16469218
Obes Surg. 2009 Oct;19(10):1414-23
19172368
J Nutr Biochem. 2002 Apr;13(4):190-199
11988401
Obes Surg. 2005 Apr;15(4):474-81
15946424
Obes Surg. 2005 Aug;15(7):1030-3
16105402
Gastroenterology. 1998 Dec;115(6):1346-52
9834261
Obes Surg. 2008 May;18(5):487-96
18357494
Surg Today. 2008;38(6):481-3
18516524
Gut. 1992 Aug;33(8):1042-3
1398229
Curr Opin Gastroenterol. 2001 Mar;17(2):99-103
11224663
Am J Surg. 2008 Nov;196(5):e56-9
18954593
Biochem Biophys Res Commun. 2000 Oct 5;276(3):905-8
11027567
Endocrinology. 2005 May;146(5):2369-75
15718279
J Clin Endocrinol Metab. 2001 Oct;86(10):4753-8
11600536
Obes Surg. 2003 Dec;13(6):889-92
14738676
Nature. 2000 Oct 19;407(6806):908-13
11057670
J Surg Res. 2003 Aug;113(2):217-21
12957132
Surg Endosc. 2007 Oct;21(10):1810-6
17356932
Obes Surg. 1998 Jun;8(3):253-60
9678192
J Clin Endocrinol Metab. 2002 Apr;87(4):1708-16
11932305
Nature. 2001 Jan 11;409(6817):194-8
11196643
Obes Surg. 2006 Sep;16(9):1138-44
16989696
Obes Surg. 2006 Oct;16(10):1323-6
17059741
Obes Surg. 2006 Nov;16(11):1425-32
17132406