title: Fat-suppressed 3D T1-weighted gradient-echo imaging of the cartilage with a volumetric interpolated breath-hold examination.
abstract: OBJECTIVE
  The purpose of our study was to evaluate the feasibility of using fat-suppressed 3D volumetric interpolated breath-hold examination (VIBE) as a substitute for fat-suppressed 3D FLASH in cartilage MRI.
  
  
  METHODS
  Fat-suppressed 3D VIBE and fat-suppressed 3D FLASH were prospectively performed in 82 patients. The acquisition time of these two sequences were 2 minutes 42 seconds and 3 minutes 53 seconds, respectively. Quantitative comparisons were made by calculating signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR), and qualitative comparisons were made on the basis of two subjective scoring systems evaluating image artifacts and cartilage conspicuousness. In addition, in a subgroup of the 43 patients who underwent arthroscopy with cartilage grading, sensitivity and specificity of these two sequences for cartilage lesions were determined in comparison.
  
  
  RESULTS
  Fat-suppressed 3D VIBE provided significantly higher cartilage SNR, cartilage-to-synovial fluid CNR, cartilage-to-meniscus CNR, and cartilage-to-bone marrow CNR than fat-suppressed 3D FLASH. Significantly less pulsation artifact and more severe truncation artifact were seen with fat-suppressed 3D VIBE. Deep cartilage surface conspicuousness in fat-suppressed 3D VIBE was better than that in fat-suppressed 3D FLASH, but superficial conspicuousness was relatively worse. In the patients who underwent arthroscopy, sensitivity and specificity for detecting cartilage lesions of grade 2 or higher were comparable for both sequences, with fat-suppressed 3D VIBE at 78.3% and 97.8% and fat-suppressed 3D FLASH at 79.7% and 97.5%, respectively.
  
  
  CONCLUSIONS
  Fat-suppressed 3D VIBE is a promising substitute for fat-suppressed 3D FLASH as a more effective T1-weighted sequence in cartilage imaging.
authors.affiliation: Department of Radiology, Peking University Third Hospital, 49 N Garden Rd, Haidian District, Beijing 100191, China.
authors.forename: Zhuo-Zhao
authors.initials: ZZ
authors.lastname: Zheng
authors.forename: Han
authors.initials: H
authors.lastname: Shan
authors.forename: Xuan
authors.initials: X
authors.lastname: Li
mesh_terms: D000273:Adipose Tissue / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D016477:Artifacts; D002358:Cartilage, Articular / Q000293:injuries* / Q000473:pathology*; D017352:Echo-Planar Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D015656:Respiratory Mechanics; D012680:Sensitivity and Specificity; D055815:Young Adult