title: Salivary biosensors for screening trauma-related psychopathology.
abstract: After facial trauma, a distinct subset of patients goes on to develop mental health problems including recalcitrant psychopathology. Early identification of maladaptive stress reactions provides opportunities for initiating preemptive mental health interventions and hinges on the surgeon's ability to differentiate between transient distress and precursors of recalcitrant psychiatric sequelae. The comprehensive care of injured patients will benefit greatly from objective adjuncts and decision-making tools to complement the clinical evaluation. This article addresses meeting the need for practical, standardized, and reliable screening strategies through promising developments in the use of stress response biomarkers and biosensing technology. The systematic interrogation of differentially expressed stress response biomarkers in saliva now permits rapid assessment of the psychopathogical response to the stressor. Quantitative, point-of-use measurements of the traumatic stress response will greatly improve the nosology of posttraumatic stress disorders and help advance the screening, diagnosis, treatment, and prevention of mental health consequences of violence and trauma.
authors.affiliation: Section of Oral and Maxillofacial Surgery, 23-009 UCLA School of Dentistry, University of California, 10833 Le Conte Avenue, Los Angeles, CA 90095-1668, USA. vshetty@ucla.edu <vshetty@ucla.edu>
authors.forename: Vivek
authors.initials: V
authors.lastname: Shetty
authors.forename: Masaki
authors.initials: M
authors.lastname: Yamaguchi
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D015374:Biosensing Techniques / Q000295:instrumentation*; D005151:Facial Injuries / Q000150:complications*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008403:Mass Screening / Q000379:methods; D001523:Mental Disorders / Q000175:diagnosis* / Q000209:etiology; D010913:Pituitary-Adrenal System / Q000502:physiology; D019095:Point-of-Care Systems; D012463:Saliva / Q000737:chemistry*; D012815:Signal Processing, Computer-Assisted; D013313:Stress Disorders, Post-Traumatic / Q000175:diagnosis / Q000209:etiology; D013312:Stress, Physiological / Q000502:physiology
chemical_list: D015415:Biomarkers
references.citation: Horm Res. 1995;44(5):213-7
references.pmid: 8582713
references.citation: Psychiatry Res. 2008 Oct 30;161(1):67-75
references.pmid: 18789538
references.citation: Int J Psychophysiol. 2000 Apr;36(1):59-68
references.pmid: 10700623
references.citation: J Clin Endocrinol Metab. 1992 May;74(5):1176-83
references.pmid: 1314847
references.citation: Isr J Med Sci. 1984 Apr;20(4):360-3
references.pmid: 6735713
references.citation: Ann N Y Acad Sci. 1995 Dec 29;771:1-18
references.pmid: 8597390
references.citation: J Am Dent Assoc. 2003 May;134(5):613-20; quiz 633
references.pmid: 12785497
references.citation: Arch Oral Biol. 1988;33(4):271-80
references.pmid: 3165262
references.citation: Psychoneuroendocrinology. 2006 Jan;31(1):49-58
references.pmid: 16002223
references.citation: Clin Diagn Lab Immunol. 2004 Sep;11(5):909-12
references.pmid: 15358651
references.citation: Biosens Bioelectron. 2004 Oct 15;20(3):491-7
references.pmid: 15494230
references.citation: Ann N Y Acad Sci. 2007 Mar;1098:510-5
references.pmid: 17435161
references.citation: J Trauma. 2008 Jul;65(1):196-202
references.pmid: 18580531
references.citation: Handb Exp Pharmacol. 2005;(169):371-403
references.pmid: 16594265
references.citation: Ann N Y Acad Sci. 2006 Jul;1071:221-30
references.pmid: 16891573
references.citation: Psychoneuroendocrinology. 1994;19(4):313-33
references.pmid: 8047637
references.citation: Biosens Bioelectron. 2003 May;18(5-6):835-40
references.pmid: 12706599
references.citation: Neuropsychopharmacology. 2000 Feb;22(2):108-24
references.pmid: 10649824
references.citation: J Trauma. 2009 Feb;66(2):477-84
references.pmid: 19204524
references.citation: Am J Geriatr Psychiatry. 1997 Spring;5(2):172-6
references.pmid: 9106381
references.citation: Biol Psychiatry. 2000 May 15;47(10):891-901
references.pmid: 10807962
references.citation: J Calif Dent Assoc. 2006 Apr;34(4):283-5
references.pmid: 16900985
references.citation: Curr Opin Psychiatry. 2006 Mar;19(2):180-3
references.pmid: 16612200
references.citation: Biosens Bioelectron. 2006 Jan 15;21(7):1007-14
references.pmid: 15871919
references.citation: Clin Chim Acta. 2007 Aug;383(1-2):30-40
references.pmid: 17512510
references.citation: CNS Spectr. 2003 Sep;8(9):651-6, 665-7
references.pmid: 15079139
references.citation: J Am Soc Psychosom Dent Med. 1983;30(3):85-96
references.pmid: 6195139
references.citation: Psychosom Med. 2003 Mar-Apr;65(2):245-58
references.pmid: 12651992
references.citation: Ann N Y Acad Sci. 2004 Dec;1032:258-63
references.pmid: 15677423
references.citation: J Human Stress. 1981 Sep;7(3):19-26
references.pmid: 7276547
references.citation: Life Sci. 1997;61(17):1705-12
references.pmid: 9363986
references.citation: Int J Nanomedicine. 2006;1(4):433-40
references.pmid: 17722277
references.citation: Ann N Y Acad Sci. 2006 Jul;1071:27-40
references.pmid: 16891559
references.citation: Psychosom Med. 1996 Jul-Aug;58(4):374-82
references.pmid: 8827800
references.citation: Ann N Y Acad Sci. 2006 Jul;1071:137-66
references.pmid: 16891568
references.citation: Am J Psychiatry. 2004 Feb;161(2):195-216
references.pmid: 14754765
references.citation: J Int Med Res. 2006 Jan-Feb;34(1):30-41
references.pmid: 16604821
references.citation: Environ Health Prev Med. 1999 Apr;4(1):1-8
references.pmid: 21432164
references.citation: J Int Med Res. 2007 Jan-Feb;35(1):91-100
references.pmid: 17408059
references.citation: Horm Metab Res. 1979 Jul;11(7):454
references.pmid: 314413
references.citation: J Am Dent Assoc. 1993 Jan;124(1):85-7
references.pmid: 8445148
references.citation: Int J Psychophysiol. 2005 Mar;55(3):333-42
references.pmid: 15708646