The formation of osteoclasts in multiple myeloma bone disease patients involves the secretion of soluble decoy receptor 3.
Soluble decoy receptor 3 (DcR3), a member of the tumor necrosis factor receptor superfamily, has recently been reported to increase osteoclast (OC) differentiation. Its impact on the skeleton was reinforced by a study on DcR3 transgenic mice showing a decreased bone mass through the elevation of OC number, providing some initial evidence of DcR3 involvement in bone diseases. In this study we show that malignant plasma cells and T lymphocytes from myeloma patients directly produce DcR3, and this molecule supports the elevated formation of OCs in both peripheral blood and bone marrow from the patients. We also show that serum DcR3 levels in myeloma patients are significantly higher compared to controls.
Brunetti
Giacomina
G
Department of Human Anatomy and Histology, University of Bari, Bari, Italy.
Oranger
Angela
A
Mori
Giorgio
G
Centonze
Matteo
M
Colaianni
Graziana
G
Rizzi
Rita
R
Liso
Vincenzo
V
Zallone
Alberta
A
Grano
Maria
M
Colucci
Silvia
S
D000368:Aged; D001773:Blood Cells / Q000378:metabolism; D001847:Bone Diseases / Q000097:blood / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D016022:Case-Control Studies; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D010010:Osteoclasts / Q000187:drug effects / Q000502:physiology*; D010950:Plasma Cells / Q000378:metabolism / Q000473:pathology; D053245:RANK Ligand / Q000378:metabolism; D053323:Receptors, Tumor Necrosis Factor, Member 6b / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology / Q000502:physiology*; D012995:Solubility; D013601:T-Lymphocytes / Q000378:metabolism / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D053245:RANK Ligand; D053323:Receptors, Tumor Necrosis Factor, Member 6b; C505688:TNFSF11 protein, human; D014409:Tumor Necrosis Factor-alpha