title: Histone acetylation in heterochromatin assembly.
abstract: Histone acetylation is generally considered a mark involved in activating gene expression by making chromatin structures less compact. In the April 1, 2010, issue of Genes & Development, Xhemalce and Kouzarides (pp. 647-652) demonstrate that the acetylation of histone H3 at Lys 4 (H3K4) plays a role in the formation of repressive heterochromatin in Schizosaccharomyces pombe. H3K4 acetylation mediates a switch of chromodomain proteins associated with methylated H3K9 during heterochromatin assembly.
authors.affiliation: Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
authors.forename: Jeong-Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Jerry L
authors.initials: JL
authors.lastname: Workman
mesh_terms: D000107:Acetylation; D000595:Amino Acid Sequence; D000818:Animals; D006570:Heterochromatin / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D012568:Schizosaccharomyces / Q000235:genetics* / Q000378:metabolism*; D016415:Sequence Alignment
chemical_list: D006570:Heterochromatin; D006657:Histones
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