title: Feasibility of neuroendoscopic biopsy of pediatric brain tumors.
abstract: OBJECTIVE
  The purpose of this study was to investigate the potential value of neuroendoscopic biopsies in pediatric patients with peri- or intraventricular tumors.
  
  
  METHODS
  From 2001 to 2008, 49 pediatric patients (mean age, 12.16 years) with tumors located in the intraventricular or paraventricular areas underwent neuroendoscopic biopsy, with or without simultaneous endoscopic third ventriculostomy. Neuroendoscopic biopsies were performed to verify the histological diagnosis of neoplasms and to establish pathological diagnoses necessary for planning appropriate treatment strategies.
  
  
  RESULTS
  In 45 of 49 patients (91.8%) neuroendoscopic biopsy specimens were appropriate for diagnosis and revealed 27 germinomas, 11 astrocytomas, and one ependymoma, etc. The tumor location included the pineal gland (n = 28), thalamus (n = 7), intraventricle (n = 3), hypothalamus (n = 3), suprasellar area (n = 2), and diffuse multifocal area (n = 3). In two patients (4.1%) biopsy specimens were informative but not diagnostic. Tumor tissue specimens were undiagnostic in two patients (4.1%). There were eight transient morbidities, including four EOM limitations, two central DI, one EVD infection, and one CSF leakage. One patient experienced postoperative tumor bleeding requiring emergent operation. There was no case of operative mortality.
  
  
  CONCLUSIONS
  Neuroendoscopic biopsy can be considered as the first choice for tissue sampling of periventricular and intraventricular tumors with acceptable risks.
authors.affiliation: Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University, School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul 135-710, South Korea.
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Song
authors.forename: Doo-Sik
authors.initials: DS
authors.lastname: Kong
authors.forename: Hyung Jin
authors.initials: HJ
authors.lastname: Shin
mesh_terms: D000293:Adolescent; D001706:Biopsy / Q000379:methods*; D001932:Brain Neoplasms / Q000473:pathology*; D002551:Cerebral Ventricle Neoplasms / Q000473:pathology*; D002552:Cerebral Ventricles / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000473:pathology*; D007031:Hypothalamus / Q000473:pathology; D007223:Infant; D008297:Male; D044583:Neuroendoscopy / Q000379:methods*; D010870:Pineal Gland / Q000473:pathology; D010871:Pinealoma / Q000473:pathology*; D011183:Postoperative Complications / Q000209:etiology; D013786:Thalamic Diseases / Q000473:pathology*; D013788:Thalamus / Q000473:pathology; D055815:Young Adult
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