title: Laryngeal dedifferentiated liposarcoma.
abstract: BACKGROUND
  Soft tissue liposarcomas are quite common in the adult population, whereas liposarcoma of the larynx is exceedingly rare.
  
  
  METHODS
  We describe an exceptional case of liposarcoma of the posterior aspect of the left arytenoid in a 62-year-old woman who was treated with two endoscopic excisions and adjuvant radiotherapy (RT). This is the 32nd case of laryngeal liposarcoma reported in the English literature.
  
  
  RESULTS
  After a 20 months follow-up, no local, regional recurrences or distant metastases were detected, and no functional complications are described for the patient.
  
  
  CONCLUSIONS
  This case report highlights that endoscopic surgical treatment enables excellent organ and functional preservation. However, recurrence of laryngeal liposarcoma is the principal risk, so extended follow-up is essential. RT has no defined role in treatment but can be discussed, especially considering the surgical margins and recurrence status.
authors.affiliation: Head and Neck Surgery Department, CHU Montpellier, Montpellier, France. m-makeieff@chu-montpellier.fr
authors.forename: Marc
authors.initials: M
authors.lastname: Makeieff
authors.forename: Pierfrancesco
authors.initials: P
authors.lastname: Pelliccia
authors.forename: Flora
authors.initials: F
authors.lastname: Poizat
authors.forename: Sebastien
authors.initials: S
authors.lastname: Arnaud
authors.forename: Florien
authors.initials: F
authors.lastname: Rat
authors.forename: Didier
authors.initials: D
authors.lastname: Cupissol
authors.forename: Bernard
authors.initials: B
authors.lastname: Guerrier
authors.forename: Valérie
authors.initials: V
authors.lastname: Costes
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D054337:Cell Dedifferentiation / Q000502:physiology*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D007821:Laryngeal Muscles / Q000473:pathology / Q000601:surgery; D007822:Laryngeal Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D007828:Laryngoscopy; D007830:Larynx / Q000473:pathology; D008080:Liposarcoma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008197:Lymph Node Excision; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D020266:Radiotherapy, Conformal; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor
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