title: Role of body mass index as a risk and prognostic factor of endometrioid uterine cancer in Korean women.
abstract: OBJECTIVE
  We aimed to evaluate the role of body mass index (BMI) as a risk and prognostic factor of endometrioid uterine cancer in Korean women.
  
  
  METHODS
  The records of 937 patients with endometrioid uterine cancer treated between 2000 and 2006 in Korea were reviewed. To determine the disease risk by BMI, four age-matched controls were recruited from healthy women (1-year age group).
  
  
  RESULTS
  The obese (BMI > or =25 kg/m(2)) and overweight (23 kg/m(2)< or = BMI <25 kg/m(2)) women had an increased risk for endometrioid uterine cancer (OR=3.161, 95% CI=2.655-3.763 and OR=1.536, 95% CI=1.260-1.873, respectively) compared to the non-obese (BMI <23 kg/m(2)) women. That is, an increment of 1 kg/m(2) caused an 18% increase in the endometrioid uterine cancer risk (OR=1.181, 95% CI=1.155-1.207). However, there was no difference in overall survival according to the BMI-based subgroups (log-rank=0.366, p=0.8328). The crude Cox model showed that obesity was not associated with the patients' overall survival when the obese and non-obese women were compared (crude HR=0.82, 95% CI=0.40-1.66). Furthermore, there was a significant trend toward a better prognosis at increased increments of BMI (p for trend<0.001), but this was not found in the multivariate analysis.
  
  
  CONCLUSIONS
  A high BMI was a significant risk factor for endometrioid uterine cancer in an Asian population. However, it was not associated with overall survival, in spite of the earlier tumor stage of the obese women.
authors.affiliation: Department of Obstetrics and Gynecology, School of Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Nan-Hee
authors.initials: NH
authors.lastname: Jeong
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Jae-Kwan
authors.initials: JK
authors.lastname: Lee
authors.forename: Jae Weon
authors.initials: JW
authors.lastname: Kim
authors.forename: Chi-Heum
authors.initials: CH
authors.lastname: Cho
authors.forename: Seok-Mo
authors.initials: SM
authors.lastname: Kim
authors.forename: Sang-Soo
authors.initials: SS
authors.lastname: Seo
authors.forename: Chan-Yong
authors.initials: CY
authors.lastname: Park
authors.forename: Ki-Tae
authors.initials: KT
authors.lastname: Kim
authors.forename: Juneyoung
authors.initials: J
authors.lastname: Lee
mesh_terms: D015992:Body Mass Index; D018269:Carcinoma, Endometrioid / Q000453:epidemiology*; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors