Innate immunity and the pathogenesis of type 1 diabetes.
Type 1 diabetes mellitus is an autoimmune disease caused by the immune-mediated destruction of insulin-producing pancreatic beta cells occurring in genetically predisposed individuals, with consequent hyperglycemia and serious chronic complications. Studies in man and in experimental animal models have shown that both innate and adaptive immune responses participate to disease pathogenesis, possibly reflecting the multifactorial pathogenetic nature of this autoimmune disorder, with the likely involvement of environmental factors occurring at least in a subset of individuals. As a consequence, components of both innate and adaptive immune response should be considered as potential targets of therapeutic strategies for disease prevention and cure. Here we review the contribution of innate immune response to type 1 diabetes, with a particular emphasis to Toll-like receptors (TLR) and NK cells.
Grieco
Fabio Arturo
FA
Diabetes Unit, Department of Internal Medicine, Endocrine and Metabolic Sciences and Biochemistry, University of Siena, Siena, Italy.
Vendrame
Francesco
F
Spagnuolo
Isabella
I
Dotta
Francesco
F
D056704:Adaptive Immunity; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D007113:Immunity, Innate; D051193:Toll-Like Receptors / Q000276:immunology
D051193:Toll-Like Receptors
Diabetes. 1992 Aug;41(8):1016-21
1628761
Nat Immunol. 2002 Sep;3(9):807-13
12205470
J Immunol. 1999 Apr 1;162(7):3749-52
10201887
Curr Opin Immunol. 2009 Dec;21(6):634-40
19892538
Diabetologia. 1993 Jul;36(7):596-601
7689498
Diabetes. 2008 Nov;57(11):3090-8
18650365
Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5115-20
17360338
J Exp Med. 2005 Jan 3;201(1):19-25
15630134
Endocrinology. 2002 Apr;143(4):1225-34
11897677
Diabetologia. 2009 Aug;52(8):1665-8
19455302
Diabetes. 2003 Oct;52(10):2639-42
14514651
Immunity. 2007 Aug;27(2):321-33
17707128
Int J Biochem Cell Biol. 2006;38(5-6):721-5
16226050
Blood. 2009 Feb 12;113(7):1399-407
18757776
Diabetes. 1990 Jul;39(7):836-43
2191887
Diabetologia. 1987 Dec;30(12):907-11
3436487
J Immunol. 2001 Aug 1;167(3):1179-87
11466332
Diabetes. 1983 Mar;32(3):247-53
6298042
J Immunol. 1986 Sep 15;137(6):1860-6
3745917
Nat Med. 2005 Oct;11(10):1059-65
16155578
J Immunol. 2004 Mar 1;172(5):3173-80
14978124
Nat Rev Immunol. 2003 Dec;3(12):984-93
14647480
Autoimmunity. 2007 Nov;40(7):540-5
17966045
J Immunol. 2004 Aug 15;173(4):2280-7
15294940
Diabetes. 1992 Apr;41(4):515-20
1535056
Nature. 2000 Dec 7;408(6813):740-5
11130078
J Clin Invest. 1986 Mar;77(3):916-24
3512604
Clin Dev Immunol. 2006 Jun-Dec;13(2-4):101-7
17162353
Biochem Biophys Res Commun. 2009 Oct 30;388(4):621-5
19686699
Nat Immunol. 2001 Aug;2(8):675-80
11477402
Clin Exp Immunol. 2003 Aug;133(2):208-18
12869026
Science. 2004 Mar 5;303(5663):1526-9
14976262
J Biol Chem. 2005 Oct 7;280(40):33984-91
16027122
J Clin Immunol. 1986 Sep;6(5):363-72
2429979
Cytokine. 2009 Jul;47(1):6-10
19447045
J Immunol. 2010 Mar 1;184(5):2272-80
20130214
Nat Rev Immunol. 2003 Oct;3(10):781-90
14523385
Front Biosci. 2008 May 01;13:6443-54
18508671
Diabetes. 1993 Mar;42(3):390-7
8432409
J Immunol. 2004 May 1;172(9):5356-62
15100275
Nat Rev Immunol. 2005 May;5(5):363-74
15841099
Diabetologia. 1984 Jul;27 Suppl:102-5
6237011
Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2992-7
15710891
Biochem J. 2009 Apr 28;420(1):1-16
19382893
Br Med J (Clin Res Ed). 1986 Jul 26;293(6541):244
3089475
J Autoimmun. 1989 Dec;2(6):759-76
2533502
Proc Natl Acad Sci U S A. 2004 May 25;101(21):8102-7
15141080
Diabetes. 2007 Jan;56(1):177-85
17192480
Nature. 2008 Oct 23;455(7216):1109-13
18806780
Annu Rev Immunol. 2000;18:861-926
10837078
Blood. 2008 Aug 1;112(3):461-9
18650461
J Clin Endocrinol Metab. 2008 Feb;93(2):578-83
18029454
Annu Rev Immunol. 2002;20:197-216
11861602
Nature. 2001 Oct 18;413(6857):732-8
11607032
Nature. 2001 Apr 26;410(6832):1099-103
11323673
Nat Immunol. 2004 Oct;5(10):987-95
15454922
Immunol Rev. 2000 Feb;173:89-97
10719670
Nat Rev Endocrinol. 2009 Apr;5(4):219-26
19352320
Eur J Immunol. 2008 Nov;38(11):2961-3
18979518
J Immunol. 2007 Feb 15;178(4):2141-7
17277118
Nat Immunol. 2002 Jun;3(6):499
12032557
Immunol Rev. 2008 Aug;224:70-84
18759921
Nat Immunol. 2004 Dec;5(12):1260-5
15531883
Diabetologia. 1986 Jun;29(6):352-7
3527835
J Immunol. 2008 Nov 15;181(10):7073-80
18981127
Clin Exp Immunol. 2010 Mar;159(3):338-43
20059481
Blood. 2003 Apr 15;101(8):3052-7
12480696
Int Immunol. 2009 Apr;21(4):317-37
19246554
Cell. 2006 Feb 24;124(4):783-801
16497588
J Immunol. 1999 Jul 1;163(1):57-61
10384099
Immunity. 2003 Jan;18(1):41-51
12530974
Tissue Antigens. 2007 Apr;69 Suppl 1:101-5
17445178
Diabet Med. 2006 Feb;23(2):156-63
16433713
Nat Immunol. 2010 Feb;11(2):121-8
20023661
Eur J Immunol. 2008 Nov;38(11):2942-5
18979513
Diabetes. 2001 Feb;50(2):283-90
11272138
Diabetes Res. 1991 Apr;16(4):171-5
1802483
Ann N Y Acad Sci. 2004 Dec;1037:161-9
15699512
Diabetes Res. 1991 May;17(1):37-41
1823558
Clin Exp Immunol. 2009 Feb;155(2):173-81
19128359
Diabetes. 2008 May;57(5):1236-45
18223009
Nat Immunol. 2002 Feb;3(2):196-200
11812998
Int Immunol. 2004 Jan;16(1):1-11
14688055
Nat Rev Endocrinol. 2010 Mar;6(3):158-66
20173777
J Immunol. 2004 Feb 1;172(3):1455-62
14734722
Nature. 2007 Oct 18;449(7164):819-26
17943118
Immunity. 1999 Oct;11(4):443-51
10549626
Annu Rev Immunol. 2001;19:197-223
11244035
J Autoimmun. 1995 Dec;8(6):843-57
8824710
Cell Death Differ. 2006 May;13(5):816-25
16410796
Diabetes Res Clin Pract. 1994 Feb;23(1):37-42
7516851
Immunobiology. 1990 Jun;180(4-5):431-40
2204602
Nat Immunol. 2008 May;9(5):503-10
18425107
J Immunol. 2004 Jan 15;172(2):937-42
14707066
Annu Rev Immunol. 2004;22:405-29
15032583
Eur J Immunol. 2008 Jan;38(1):82-9
18085661
Nat Med. 2007 May;13(5):543-51
17479100
Nat Immunol. 2002 Apr;3(4):373-82
11919579