Reversal of adrenal suppression with ciclesonide.
BACKGROUND
Adrenal suppression secondary to high-dose inhaled corticosteroid use has been reported in children.


METHODS
The authors report the use of ciclesonide to reverse adrenal suppression secondary to inhaled fluticasone use in four pediatric patients.


RESULTS
In these four children, hypothalamic-pituitary-adrenal axis function normalized after the patients were changed to ciclesonide, while good asthma control was maintained.


CONCLUSIONS
Ciclesonide should be considered for the reversal of adrenal suppression secondary to the use of fluticasone, and perhaps other older inhaled corticosteroids as well.
Heller
Mariel Kupfert
MK
Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
Laks
Jessica
J
Kovesi
Thomas Andrew
TA
Ahmet
Alexandra
A
D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000311:Adrenal Glands / Q000187:drug effects*; D001249:Asthma / Q000188:drug therapy*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D011282:Pregnenediones / Q000627:therapeutic use*
D000305:Adrenal Cortex Hormones; D011282:Pregnenediones; C120481:ciclesonide