The edges of understanding.
A culture's icons are a window onto its soul. Few would disagree that, in the culture of molecular biology that dominated much of the life sciences for the last third of the 20th century, the dominant icon was the double helix. In the present, post-modern, 'systems biology' era, however, it is, arguably, the hairball.
Lander
Arthur D
AD
Center for Complex Biological Systems, Department of Developmental and Cell Biology, University of California, Irvine, CA 92697, USA. adlander@uci.edu
D032882:Comprehension; D008962:Models, Theoretical; D049490:Systems Biology / Q000379:methods* / Q000639:trends*
Bioessays. 2004 Jan;26(1):99-105
14696046
Science. 2008 Oct 17;322(5900):399-403
18927385
Cell. 2005 May 20;121(4):511-513
15907465
Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10078-83
8816754
Ernst Schering Res Found Workshop. 2007;(61):117-37
17249499
Science. 2009 Apr 3;324(5923):85-9
19342587
Science. 2009 Oct 2;326(5949):53-4
19797647
J Biol. 2009;8(1):2
19222866
Dev Cell. 2006 Sep;11(3):279-87
16950120
Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4219-20
15767568
Ann Biomed Eng. 2006 Jul;34(7):1226-33
16929563