title: Secondary metabolites from the roots of Litsea hypophaea and their antitubercular activity.
abstract: Bioassay-guided fractionation of the roots of Litsea hypophaea led to the isolation of seven new butanolides, namely, litseakolides H-N (1-7), all with the 3R,4S configuration, as well as three new biarylpropanoids, hypophaone (8), hypophaol (9), and hypophane (10), and 15 known compounds. The structures of 1-10 were determined by means of spectroscopic analysis. Litseakolide L (5) and N-trans-feruloylmethoxytyramine (11) showed antitubercular activity against Mycobacterium tuberculosis strain H(37)Rv, with MIC values of 25 and 1.6 microg/mL, respectively.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan 807, Republic of China.
authors.forename: Pei-Chi
authors.initials: PC
authors.lastname: Pan
authors.forename: Ming-Jen
authors.initials: MJ
authors.lastname: Cheng
authors.forename: Chien-Fang
authors.initials: CF
authors.lastname: Peng
authors.forename: Hung-Yi
authors.initials: HY
authors.lastname: Huang
authors.forename: Jih-Jung
authors.initials: JJ
authors.lastname: Chen
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032862:Litsea / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D013237:Stereoisomerism; D013624:Taiwan
chemical_list: D000995:Antitubercular Agents; D015107:4-Butyrolactone