title: Radiofrequency ablation for metastatic hepatic tumor in colorectal carcinoma.
abstract: OBJECTIVE
  The purpose of this study was to assess the efficacy and safety of radiofrequency ablation (RFA) to treat hepatic metastasis in patients with colorectal carcinoma.
  
  
  METHODS
  Between May 1999 and July 2002, a total of 45 tumors in 24 patients with colorectal cancer were treated with RFA. Thirteen patients received systemic chemotherapy after the RFA procedure. The ablation was performed percutaneously under ultrasound guidance using cool-tip or expandable electrodes and an RF generator. The medical records as well as the CT scan results taken every 3 months were retrospectively reviewed.
  
  
  RESULTS
  The median follow-up duration of the surviving patients was 11.7 months (4.6 approximately 32.2 months). Complete tumor necrosis was achieved in 17 patients (70.8%) on an immediate (<24 hrs) CT scan. The median survival was 17.1 months. The 1- and 2-year survival rates were 80.5 and 25.8%, respectively. In a univariate analysis, complete necrosis, tumor size and post-RFA chemotherapy were significant factors for survival. Nineteen of the 24 patients developed a recurrence or progressed (79.2%). The median progression free survival was 5.5 months. There were no treatment related deaths or serious adverse effects, with the exception of one case of respiratory failure.
  
  
  CONCLUSIONS
  These results suggest that RFA is a well-tolerated and effective method to treat hepatic metastasis in colorectal carcinomas.
authors.affiliation: Department of Internal Medicine, Hanyang University, Seoul, Korea.
authors.forename: Jung-Hye
authors.initials: JH
authors.lastname: Choi
authors.forename: Myung-Ju
authors.initials: MJ
authors.lastname: Ahn
authors.forename: Hyunchul
authors.initials: H
authors.lastname: Rhim
authors.forename: Heung Woo
authors.initials: HW
authors.lastname: Lee
authors.forename: Ho-Suk
authors.initials: HS
authors.lastname: Oh
authors.forename: Young-Yeul
authors.initials: YY
authors.lastname: Lee
authors.forename: Il-Young
authors.initials: IY
authors.lastname: Choi
authors.forename: In-Soon
authors.initials: IS
authors.lastname: Kim
references.citation: Acad Radiol. 1996 Nov;3(11):929-35
references.pmid: 8959183
references.citation: Radiology. 2000 Mar;214(3):761-8
references.pmid: 10715043
references.citation: J Urol. 1999 Feb;161(2):599-600
references.pmid: 9915457
references.citation: Ann Surg Oncol. 2003 Jan-Feb;10(1):52-8
references.pmid: 12513961
references.citation: Ann Surg. 1996 Oct;224(4):509-20; discussion 520-2
references.pmid: 8857855
references.citation: J Clin Oncol. 2002 Mar 15;20(6):1499-505
references.pmid: 11896097
references.citation: Ann Surg. 1999 Jul;230(1):1-8
references.pmid: 10400029
references.citation: AJR Am J Roentgenol. 1996 Sep;167(3):759-68
references.pmid: 8751696
references.citation: N Engl J Med. 1999 Dec 30;341(27):2039-48
references.pmid: 10615075
references.citation: Am J Surg. 1999 Apr;177(4):303-6
references.pmid: 10326848
references.citation: Surgery. 2001 Dec;130(6):971-7
references.pmid: 11742325
references.citation: Cancer. 2003 Jun 15;97(12):3027-35
references.pmid: 12784338
references.citation: Radiographics. 2001 Oct;21 Spec No:S17-35; discussion S36-9
references.pmid: 11598245
references.citation: Radiology. 1997 Nov;205(2):367-73
references.pmid: 9356616
references.citation: Cancer. 2000 Jun 1;88(11):2452-63
references.pmid: 10861420
references.citation: World J Surg. 1995 Jan-Feb;19(1):59-71
references.pmid: 7740812
references.citation: Radiology. 1995 Nov;197(2):451-4
references.pmid: 7480692
references.citation: Radiology. 2001 Oct;221(1):159-66
references.pmid: 11568334
references.citation: Cancer J. 2002 Jan-Feb;8(1):33-9
references.pmid: 11898806