title: Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy.
abstract: Adipose tissue secretes a variety of bioactive factors, which can regulate cardiomyocyte hypertrophy via reactive oxygen species (ROS). In the present study we investigated whether apelin affects ROS-dependent cardiac hypertrophy. In cardiomyocytes apelin inhibited the hypertrophic response to 5-HT and oxidative stress induced by 5-HT- or H(2)O(2) in a dose-dependent manner. These effects were concomitant to the increase in mRNA expression and activity of catalase. Chronic treatment of mice with apelin attenuated pressure-overload-induced left ventricular hypertrophy. The prevention of hypertrophy by apelin was associated with increased myocardial catalase activity and decreased plasma lipid hydroperoxide, as an index of oxidative stress. These results show that apelin behaves as a catalase activator and prevents cardiac ROS-dependent hypertrophy.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U858, Toulouse, France.
authors.forename: Camille
authors.initials: C
authors.lastname: Foussal
authors.forename: Olivier
authors.initials: O
authors.lastname: Lairez
authors.forename: Denis
authors.initials: D
authors.lastname: Calise
authors.forename: Atul
authors.initials: A
authors.lastname: Pathak
authors.forename: Celine
authors.initials: C
authors.lastname: Guilbeau-Frugier
authors.forename: Philippe
authors.initials: P
authors.lastname: Valet
authors.forename: Angelo
authors.initials: A
authors.lastname: Parini
authors.forename: Oksana
authors.initials: O
authors.lastname: Kunduzova
mesh_terms: D000818:Animals; D006332:Cardiomegaly / Q000517:prevention & control*; D002374:Catalase / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D006984:Hypertrophy / Q000378:metabolism; D017379:Hypertrophy, Left Ventricular / Q000378:metabolism; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D012701:Serotonin / Q000494:pharmacology
chemical_list: D017382:Reactive Oxygen Species; D012701:Serotonin; D006861:Hydrogen Peroxide; D002374:Catalase