[Biological abilities and identification of the polyene antifungal antibiotic, perspective for protection from fungi biodeterioration].
The producer of the antifungal polyene antibiotic, aimed to protect against fungial biodeterioration, has been isolated from the soil due to a target search. Based on the morphological, cultural, and biochemical abilities, the producer is related to the Streptomyces genus. It has been shown by chromatographic, spectral, physical, and chemical methods that the antibiotic synthesized by the isolated culture consists of two main components--the polyene hexaene antibiotic with a high antifungal activity and a non-polyene antibiotic with antibacterial activity. The antifungal activity of the low purified hexaene antibiotic is comparable with the antifungal activity of the well-known highly purified antibiotics--amphotericin B, clotrimazole, and itrakonazol. This antibiotic inhibits the synthesis of the biodeterioration factors in fungi, i.e., pigments and organic acids.
Kuzikova
I L
IL
Sukharevich
V I
VI
Shenin
Iu D
IuD
Medvedeva
N G
NG
D000935:Antifungal Agents / Q000378:metabolism* / Q000494:pharmacology; D005658:Fungi / Q000254:growth & development; D011090:Polyenes / Q000378:metabolism* / Q000494:pharmacology; D012988:Soil Microbiology; D013302:Streptomyces / Q000302:isolation & purification / Q000378:metabolism*
D000935:Antifungal Agents; D011090:Polyenes