title: Oxygen delivery and consumption: a macrocirculatory perspective.
abstract: Severe sepsis is a leading cause of death and resource use throughout the world. This article examines the relationship of oxygen delivery to oxygen use under varying conditions. Topics reviewed include the concept of the critical dissolved oxygen, concerns over shared measurement errors in obtaining estimates of oxygen consumption, seminal articles in this area, and the practice of early goal directed therapy.
authors.affiliation: Division of Pulmonary & Critical Care Medicine, Oregon Health and Sciences University, OHSU-UHN-67, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA. nicholda@ohsu.edu
authors.forename: Dane
authors.initials: D
authors.lastname: Nichols
authors.forename: Nathan D
authors.initials: ND
authors.lastname: Nielsen
mesh_terms: D002318:Cardiovascular Diseases / Q000097:blood; D006439:Hemodynamics; D006801:Humans; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology*; D018805:Sepsis / Q000097:blood*
chemical_list: D010100:Oxygen