Pharmacogenetics--genomics and personalized psychiatry.
Pharmacogenetic influences on therapeutic response to e.g. antidepressant or neuroleptic treatment are poorly understood and the lack of efficacy in many of the patients together with side effects can both limit therapy and compliance. Thus the aim of pharmacogenetics and pharmacogenomics is to provide predictive tools for the response to psychopharmacologic agents in the therapy of psychiatric disorders and in that ways to provide a real personalized psychiatry. The following review will summarize the current stage of pharmacogenetics and pharmacogenomics and will critically discuss the possibilities of a personalized medicine.
Möller
H J
HJ
Ludwig-Maximilians University, Munich, Germany.
Rujescu
D
D
D023281:Genomics; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D010597:Pharmacogenetics; D057285:Precision Medicine; D011570:Psychiatry