title: An open trial of intensive family based cognitive-behavioral therapy in youth with obsessive-compulsive disorder who are medication partial responders or nonresponders.
abstract: This study reports an open-trial of family-based cognitive-behavioral therapy (CBT) in children and adolescents with obsessive-compulsive disorder (OCD). Thirty primarily Caucasian youth with OCD (range = 7-19 years; 15 girls) who were partial responders or nonresponders to two or more medication trials that were delivered either serially or concomitantly received 14 sessions of intensive family-based CBT. Eighty percent of participants were considered improved at posttreatment and at 3-month follow-up, and symptom severity was reduced by 54% at both posttreatment and follow-up. Seventeen (56.6%) and 16 (53.3%) participants were classified as being in remission at posttreatment and follow-up, respectively. Significant reductions in OCD-related impairment, depressive symptoms, behavioral problems, and family accommodation were noted. No significant difference in youth-reported anxiety was found.
authors.affiliation: Departments of Pediatrics and Psychiatry, University of South Florida, Columbia, SC 29208, USA. drcherishapiro@gmail.com
authors.forename: Eric A
authors.initials: EA
authors.lastname: Storch
authors.forename: Heather D
authors.initials: HD
authors.lastname: Lehmkuhl
authors.forename: Emily
authors.initials: E
authors.lastname: Ricketts
authors.forename: Gary R
authors.initials: GR
authors.lastname: Geffken
authors.forename: Wendi
authors.initials: W
authors.lastname: Marien
authors.forename: Tanya K
authors.initials: TK
authors.lastname: Murphy
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D001007:Anxiety / Q000175:diagnosis / Q000628:therapy; D002648:Child; D015928:Cognitive Behavioral Therapy; D005196:Family Therapy; D005260:Female; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000175:diagnosis / Q000628:therapy*; D018579:Patient Selection; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D016896:Treatment Outcome; D055815:Young Adult