An analysis of clustering of betapapillomavirus antibodies.
Betapapillomaviruses (betaPVs) may contribute to the aetiology of cutaneous squamous cell carcinoma. However, no high-risk types have yet been identified, possibly because the high frequency of co-infection prevents a straightforward analysis of the independent effects of individual viruses. This study aimed to determine whether specific virus types were more likely to co-occur than others, thereby reducing the number of parameters needed in statistical models. Antibody data were analysed from controls who participated in case-control studies in The Netherlands, Italy and Australia and from participants in the German Nutrition Survey. Cluster analysis and two ordination techniques were used to identify patterns. Evidence of clustering was found only according to the number of viruses to which antibodies were detected. The lack of clustering of specific viral types identified suggests that if there are betaPV types that are independently related to skin carcinogenesis, they are unlikely to be identified using standard epidemiological methods.
Mallitt
K A
KA
Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, Australia.
O'Rourke
P
P
Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, Australia.
Bouwes Bavinck
J N
JN
Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
Abeni
D
D
Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome, Italy.
de Koning
M N C
MNC
DDL Diagnostic Laboratory, Voorburg, The Netherlands.
Feltkamp
M C W
MCW
Department of Medical Microbiology, Leiden University Medical Center, Leiden, The Netherlands.
Green
A C
AC
Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, Australia.
Quint
W G V
WGV
DDL Diagnostic Laboratory, Voorburg, The Netherlands.
Michael
K M
KM
German Cancer Research Center (DKFZ), Heidelberg, Germany.
Pawlita
M
M
German Cancer Research Center (DKFZ), Heidelberg, Germany.
Pfister
H
H
Institute of Virology, University of Cologne, Cologne, Germany.
Weissenborn
S
S
Institute of Virology, University of Cologne, Cologne, Germany.
Waterboer
T
T
German Cancer Research Center (DKFZ), Heidelberg, Germany.
Neale
R E
RE
Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, Australia.
The Epi-Hpv-Uv-Ca Group
Cancer and Population Studies Group, Queensland Institute of Medical Research, Brisbane, Australia.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood*; D001315:Australia / Q000453:epidemiology; D052686:Betapapillomavirus / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification*; D016022:Case-Control Studies; D016000:Cluster Analysis; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D015995:Prevalence; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral