Iodocionin, a cytotoxic iodinated metabolite from the Mediterranean ascidian Ciona edwardsii.
Chemical investigation of the Mediterranean ascidian Ciona edwardsii has been performed, leading to the isolation of two halogenated compounds: a new tyrosineiodinated derivative iodocionin (1) and the relevant brominated analogue (2), previously isolated from a Caribbean sponge. The structure of the new compound 1 has been assigned on the basis of spectroscopic analysis. Both compounds were tested for cytotoxicity in vitro against two different cancer cell lines, L5178Y (mouse lymphoma) and PC-12 (rat pheochromocytoma). Iodocionin was shown to possess significant and selective activity against lymphoma cells with an IC(50) of 7.75 microg/mL.
Aiello
Anna
A
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Napoli, Italy. aiello@unina.it
Fattorusso
Ernesto
E
Imperatore
Concetta
C
Menna
Marialuisa
M
Müller
Werner E G
WE
D000662:Amphetamines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D016716:PC12 Cells; D051381:Rats; D021241:Spectrometry, Mass, Electrospray Ionization; D014561:Urochordata / Q000378:metabolism*
C550776:2-(4-hydroxy-3-iodophenyl)-N,N,N-trimethylethanaminium; D000662:Amphetamines; D000970:Antineoplastic Agents
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