title: Oxidized-LDL/beta(2)-glycoprotein I complexes are associated with disease severity and increased risk for adverse outcomes in patients with acute coronary syndromes.
abstract: Oxidized low-density lipoprotein (oxLDL)/beta(2)-glycoprotein I (beta2GPI) complexes have been implicated in atherogenesis. oxLDL/beta2GPI complexes were measured in 339 patients with suspected acute coronary syndromes. Approximately 68% had angiographically documented coronary artery disease (CAD) and significantly higher mean + or - SD levels of oxLDL/beta2GPI (3.75 + or - 6.31 U/mL) than patients with normal coronary arteries (2.21 + or - 3.03 U/mL; P = .0026). Patients with severe CAD had significantly higher mean + or - SD levels of oxLDL/beta2GPI (8.71 + or - 12.87 U/mL) compared with the overall mean of 3.25 U/mL (P < .05) and a significantly higher rate (28.9%) of adverse events than the overall rate of 11.2% (P < .05). Patients with adverse events had higher mean + or - SD levels of oxLDL/beta2GPI (4.05 + or - 5.38 U/mL) than patients without adverse events (3.15 + or - 5.53; P = .029). The relative risk for adverse events in higher oxLDL/beta2GPI quartiles was 3.1 (95% confidence interval, 1.0-9.1; P = .06) for quartile 3 and 3.5 (95% confidence interval, 1.2-10.4; P = .02) for quartile 4. Our results support the concept that oxLDL/beta2GPI complexes are associated with severity of CAD and a 3.5-fold increased risk for adverse outcomes.
authors.affiliation: Department of Medicine, Saint Mary's Hospital, Waterbury, CT, USA.
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Greco
authors.forename: Ann Marie
authors.initials: AM
authors.lastname: Conti-Kelly
authors.forename: J Robert
authors.initials: JR
authors.lastname: Anthony
authors.forename: Thomas
authors.initials: T
authors.lastname: Greco
authors.forename: Robin
authors.initials: R
authors.lastname: Doyle
authors.forename: Matt
authors.initials: M
authors.lastname: Boisen
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kojima
authors.forename: Eiji
authors.initials: E
authors.lastname: Matsuura
authors.forename: Luis R
authors.initials: LR
authors.lastname: Lopez
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood / Q000473:pathology*; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000097:blood; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012307:Risk Factors; D053482:beta 2-Glycoprotein I / Q000097:blood*
chemical_list: D017152:Antibodies, Antiphospholipid; D015415:Biomarkers; D008077:Lipoproteins, LDL; D053482:beta 2-Glycoprotein I; C099252:oxidized low density lipoprotein