Complexes of 2-hydroxyacetophenone semicarbazones: A novel series of superoxide dismutase mimetics.
A series of copper(II) and zinc complexes of 2-hydroxyacetophenone semicarbazones have been prepared and evaluated as superoxide dismutase (SOD) mimetics. The SOD-like activity of parent ligands and complexes were determined by the inhibition of nitroblue tetrazolium (NBT) reduction method, using xanthine/xanthine oxidase as the superoxide radical generator. The obtained results indicate that Cu(II) complexes exhibited the most potent SOD-like activities with the IC(50) values ranging from ca. 0.2 to 4 microM. Among copper complexes, 2-hydroxy-4-methoxyacetophenone semicarbazone analog was the most active compounds (IC(50) approximately 0.2 microM).
Safavi
Maliheh
M
Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran 14174, Iran.
Foroumadi
Alireza
A
Nakhjiri
Maryam
M
Abdollahi
Mohammad
M
Shafiee
Abbas
A
Ilkhani
Hoda
H
Ganjali
Mohammad Reza
MR
Hosseinimehr
Seyed Jalal
SJ
Emami
Saeed
S
D040761:Biomimetic Materials / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry; D009580:Nitroblue Tetrazolium / Q000737:chemistry; D012664:Semicarbazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000737:chemistry / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism; D015032:Zinc / Q000737:chemistry
D056831:Coordination Complexes; D012664:Semicarbazones; D009580:Nitroblue Tetrazolium; D003300:Copper; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D015032:Zinc