No evidence for a polyomavirus association or aetiology in AIDS-associated nonsmall cell lung cancer.
AIDS-associated lung cancer has an increasing incidence, unaccounted for by smoking, and occurs consistently at a younger age than matched controls. We investigated whether known and new cancer-associated polyomaviruses, including the newly identified Merkel cell virus, may play a role in its etiopathogenesis. Although viruses target conserved pathways in cellular evolution, we are unable to suggest that the viruses studied here induce novel mechanisms of oncogenic dysregulation in AIDS-associated lung cancer.
Stebbing
Justin
J
Department of Oncology, Imperial College School of Medicine, Hammersmith Hospital, London, UK. j.stebbing@imperial.ac.uk
Wickenden
Colin
C
Castellano
Leandro
L
Sita-Lumsden
Ailsa
A
Nelson
Mark
M
Jacob
Jimmy
J
Naresh
Kikeri
K
Mauri
Francesco
F
Bower
Mark
M
D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000209:etiology* / Q000821:virology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D027601:Polyomavirus Infections / Q000150:complications* / Q000821:virology; D014412:Tumor Virus Infections / Q000150:complications / Q000821:virology