title: Production of metabolites as bacterial responses to the marine environment.
abstract: Bacteria in marine environments are often under extreme conditions of e.g., pressure, temperature, salinity, and depletion of micronutrients, with survival and proliferation often depending on the ability to produce biologically active compounds. Some marine bacteria produce biosurfactants, which help to transport hydrophobic low water soluble substrates by increasing their bioavailability. However, other functions related to heavy metal binding, quorum sensing and biofilm formation have been described. In the case of metal ions, bacteria developed a strategy involving the release of binding agents to increase their bioavailability. In the particular case of the Fe(3+) ion, which is almost insoluble in water, bacteria secrete siderophores that form soluble complexes with the ion, allowing the cells to uptake the iron required for cell functioning. Adaptive changes in the lipid composition of marine bacteria have been observed in response to environmental variations in pressure, temperature and salinity. Some fatty acids, including docosahexaenoic and eicosapentaenoic acids, have only been reported in prokaryotes in deep-sea bacteria. Cell membrane permeability can also be adapted to extreme environmental conditions by the production of hopanoids, which are pentacyclic triterpenoids that have a function similar to cholesterol in eukaryotes. Bacteria can also produce molecules that prevent the attachment, growth and/or survival of challenging organisms in competitive environments. The production of these compounds is particularly important in surface attached strains and in those in biofilms. The wide array of compounds produced by marine bacteria as an adaptive response to demanding conditions makes them suitable candidates for screening of compounds with commercially interesting biological functions. Biosurfactants produced by marine bacteria may be helpful to increase mass transfer in different industrial processes and in the bioremediation of hydrocarbon-contaminated sites. Siderophores are necessary e.g., in the treatment of diseases with metal ion imbalance, while antifouling compounds could be used to treat man-made surfaces that are used in marine environments. New classes of antibiotics could efficiently combat bacteria resistant to the existing antibiotics. The present work aims to provide a comprehensive review of the metabolites produced by marine bacteria in order to cope with intrusive environments, and to illustrate how such metabolites can be advantageously used in several relevant areas, from bioremediation to health and pharmaceutical sectors.
authors.affiliation: IBB-Institute for Biotechnology and Bioengineering, Centre for Biological and Chemical Engineering, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisbon, Portugal. ccarvalho@ist.utl.pt
authors.forename: Carla C C R
authors.initials: CC
authors.lastname: de Carvalho
authors.forename: Pedro
authors.initials: P
authors.lastname: Fernandes
mesh_terms: D000222:Adaptation, Physiological; D001419:Bacteria / Q000737:chemistry* / Q000378:metabolism*; D001688:Biological Products / Q000096:biosynthesis / Q000737:chemistry; D004777:Environment; D012623:Seawater / Q000382:microbiology*
chemical_list: D001688:Biological Products
references.citation: Biometals. 2009 Aug;22(4):625-32
references.pmid: 19350395
references.citation: Trends Microbiol. 2009 Mar;17(3):109-18
references.pmid: 19231189
references.citation: FEMS Microbiol Lett. 2009 Apr;293(1):73-8
references.pmid: 19222571
references.citation: Appl Environ Microbiol. 1987 Mar;53(3):527-32
references.pmid: 16347302
references.citation: Nature. 2001 Sep 27;413(6854):409-13
references.pmid: 11574885
references.citation: Clin Ther. 2007 Oct;29(10):2154-66
references.pmid: 18042472
references.citation: Proc Natl Acad Sci U S A. 2003 Apr 1;100(7):3754-9
references.pmid: 12651947
references.citation: Appl Biochem Biotechnol. 2004 Jul-Sep;118(1-3):243-51
references.pmid: 15304753
references.citation: Bacteriol Rev. 1974 Mar;38(1):87-110
references.pmid: 4601163
references.citation: Appl Environ Microbiol. 2009 Feb;75(3):567-72
references.pmid: 19060172
references.citation: Appl Microbiol Biotechnol. 2009 Feb;82(2):311-20
references.pmid: 19096838
references.citation: Nat Rev Microbiol. 2007 Apr;5(4):316-23
references.pmid: 17334387
references.citation: Coord Chem Rev. 2010 Feb 1;254(3-4):288-296
references.pmid: 21442004
references.citation: Appl Environ Microbiol. 2008 Aug;74(15):4867-76
references.pmid: 18552188
references.citation: J Antibiot (Tokyo). 1975 Mar;28(3):176-84
references.pmid: 1126873
references.citation: Bacteriol Rev. 1965 Mar;29:9-24
references.pmid: 14295987
references.citation: J Nat Prod. 2007 Nov;70(11):1746-52
references.pmid: 17958395
references.citation: Proc Natl Acad Sci U S A. 2002 May 14;99(10):7072-7
references.pmid: 11997446
references.citation: J Nat Prod. 2004 Nov;67(11):1897-9
references.pmid: 15568785
references.citation: Environ Microbiol. 2007 Sep;9(9):2175-88
references.pmid: 17686016
references.citation: Water Sci Technol. 2001;43(6):1-8
references.pmid: 11381954
references.citation: Plant Physiol. 1988 Jul;87(3):680-5
references.pmid: 16666207
references.citation: Appl Environ Microbiol. 2002 Jan;68(1):372-8
references.pmid: 11772647
references.citation: Chem Rev. 2009 Oct;109(10):4580-95
references.pmid: 19772347
references.citation: Biometals. 2009 Aug;22(4):659-69
references.pmid: 19343508
references.citation: Breast Cancer Res Treat. 2001 Sep;69(1):69-79
references.pmid: 11759830
references.citation: Saline Syst. 2009 Nov 23;5:9
references.pmid: 19930649
references.citation: J Appl Microbiol. 2007 Nov;103(5):1716-27
references.pmid: 17953582
references.citation: Appl Environ Microbiol. 1996 Sep;62(9):3265-9
references.pmid: 16535400
references.citation: Curr Top Med Chem. 2001 May;1(1):73-82
references.pmid: 11895295
references.citation: FEBS Lett. 1980 Apr 21;113(1):107-10
references.pmid: 7380001
references.citation: Mar Biotechnol (NY). 2009 Jul-Aug;11(4):431-40
references.pmid: 19424754
references.citation: Pathol Biol (Paris). 2004 Apr;52(3):127-30
references.pmid: 15063931
references.citation: Curr Pharm Biotechnol. 2007 Oct;8(5):253-60
references.pmid: 17979723
references.citation: J Nat Prod. 2003 Jun;66(6):818-22
references.pmid: 12828468
references.citation: Nat Prod Rep. 2007 Aug;24(4):814-42
references.pmid: 17653361
references.citation: Biometals. 2009 Dec;22(6):965-72
references.pmid: 19459055
references.citation: Trends Microbiol. 2007 Nov;15(11):491-9
references.pmid: 17997312
references.citation: FEMS Microbiol Ecol. 2005 Feb 1;51(3):389-99
references.pmid: 16329886
references.citation: Int J Med Microbiol. 2006 Apr;296(2-3):61-71
references.pmid: 16487746
references.citation: Annu Rev Med. 2009;60:25-38
references.pmid: 19630568
references.citation: Environ Microbiol. 1999 Jun;1(3):191-8
references.pmid: 11207738
references.citation: Annu Rev Microbiol. 1996;50:727-51
references.pmid: 8905097
references.citation: Appl Environ Microbiol. 1997 Jul;63(7):2572-7
references.pmid: 16535638
references.citation: Appl Environ Microbiol. 1986 Jun;51(6):1224-9
references.pmid: 16347080
references.citation: Environ Sci Technol. 2008 Dec 1;42(23):8675-80
references.pmid: 19192780
references.citation: Adv Microb Physiol. 1972;8:143-213
references.pmid: 4581483
references.citation: Proc Natl Acad Sci U S A. 1974 Feb;71(2):522-5
references.pmid: 4360948
references.citation: J Bioenerg Biomembr. 1989 Feb;21(1):93-113
references.pmid: 2651429
references.citation: J Biol Inorg Chem. 2006 Jul;11(5):633-41
references.pmid: 16791646
references.citation: FEMS Microbiol Lett. 1999 Nov 15;180(2):123-31
references.pmid: 10556702
references.citation: Microbiol Sci. 1984 Apr;1(1):9-14
references.pmid: 6242877
references.citation: Prog Lipid Res. 2004 Sep;43(5):383-402
references.pmid: 15458813
references.citation: Biometals. 2002 Jun;15(2):153-60
references.pmid: 12046923
references.citation: Ann Intern Med. 1994 Mar 15;120(6):490-9
references.pmid: 8311372
references.citation: FEMS Microbiol Lett. 2000 May 15;186(2):193-5
references.pmid: 10802170
references.citation: J Bacteriol. 1955 Nov;70(5):568-71
references.pmid: 13271293
references.citation: Biometals. 1994 Apr;7(2):109-16
references.pmid: 8148612
references.citation: Annu Rev Microbiol. 1983;37:1-23
references.pmid: 6357049
references.citation: Appl Microbiol Biotechnol. 2002 Jul;59(2-3):125-34
references.pmid: 12111137
references.citation: J Am Chem Soc. 2006 Feb 1;128(4):1064-5
references.pmid: 16433508
references.citation: Antonie Van Leeuwenhoek. 2003;83(3):275-83
references.pmid: 12776923
references.citation: Appl Environ Microbiol. 2001 Apr;67(4):1710-7
references.pmid: 11282625
references.citation: Microbiol Res. 2003;158(3):243-8
references.pmid: 14521234
references.citation: Mar Drugs. 2007 Sep 19;5(3):85-112
references.pmid: 18463721
references.citation: Appl Microbiol Biotechnol. 2003 Jan;60(5):495-506
references.pmid: 12536248
references.citation: Eur J Haematol. 2009 Jun;82(6):458-65
references.pmid: 19187278
references.citation: J Bacteriol. 1984 Dec;160(3):879-83
references.pmid: 6501232
references.citation: Biometals. 2009 Aug;22(4):565-71
references.pmid: 19357970
references.citation: PLoS Biol. 2005 Aug;3(8):e273
references.pmid: 16008504
references.citation: Inorg Chem. 2009 Dec 7;48(23):11466-73
references.pmid: 19902959
references.citation: J Antibiot (Tokyo). 1987 Dec;40(12):1671-6
references.pmid: 2962973
references.citation: Trends Biotechnol. 2009 Jan;27(1):45-52
references.pmid: 19022511
references.citation: PLoS One. 2008 Jul 23;3(7):e2744
references.pmid: 18648491
references.citation: Appl Environ Microbiol. 2000 Jul;66(7):2797-803
references.pmid: 10877770
references.citation: Microbiol Rev. 1995 Jun;59(2):201-22
references.pmid: 7603409
references.citation: J Appl Microbiol. 2008 Nov;105(5):1672-7
references.pmid: 18828792
references.citation: Science. 2000 Feb 18;287(5456):1245-7
references.pmid: 10678827
references.citation: Trends Biotechnol. 2005 Sep;23(9):437-40
references.pmid: 16038996
references.citation: Ann Rev Mar Sci. 2009;1:43-63
references.pmid: 21141029
references.citation: Biotechnol Adv. 2009 Jul-Aug;27(4):521-39
references.pmid: 19393308
references.citation: J Am Chem Soc. 2007 Jan 24;129(3):478-9
references.pmid: 17226996
references.citation: Curr Med Chem. 2009;16(19):2416-29
references.pmid: 19601789
references.citation: Appl Microbiol Biotechnol. 2007 Oct;76(5):1017-26
references.pmid: 17641887
references.citation: Trends Microbiol. 2003 Aug;11(8):347-50
references.pmid: 12915091
references.citation: Res Microbiol. 2002 Jun;153(5):263-8
references.pmid: 12160316
references.citation: J Am Chem Soc. 2002 Jan 23;124(3):378-9
references.pmid: 11792199
references.citation: Biochim Biophys Acta. 1996 Oct 29;1286(3):225-45
references.pmid: 8982284
references.citation: Met Ions Biol Syst. 1998;35:239-327
references.pmid: 9444763
references.citation: J Appl Microbiol. 2008 Jun;104(6):1675-84
references.pmid: 18194244
references.citation: Curr Microbiol. 2004 Oct;49(4):300-7
references.pmid: 15386120
references.citation: J Am Chem Soc. 2007 Oct 10;129(40):12263-71
references.pmid: 17850151
references.citation: FEMS Microbiol Ecol. 2004 Mar 1;47(3):371-9
references.pmid: 19712325
references.citation: Biotechnol Adv. 2006 Mar-Apr;24(2):134-42
references.pmid: 16169182
references.citation: Stud Hist Philos Biol Biomed Sci. 2007 Dec;38(4):820-33
references.pmid: 18053936
references.citation: Microb Ecol. 1997 Nov;34(3):232-6
references.pmid: 9337418
references.citation: J Nat Prod. 2009 May 22;72(5):884-8
references.pmid: 19320498
references.citation: Antimicrob Agents Chemother. 2002 Jun;46(6):2010-3
references.pmid: 12019128
references.citation: Microbiol Mol Biol Rev. 2009 Jun;73(2):249-99
references.pmid: 19487728
references.citation: Nat Chem Biol. 2007 Jul;3(7):408-14
references.pmid: 17576428