Aggression and anxiety: social context and neurobiological links.
Psychopathologies such as anxiety- and depression-related disorders are often characterized by impaired social behaviours including excessive aggression and violence. Excessive aggression and violence likely develop as a consequence of generally disturbed emotional regulation, such as abnormally high or low levels of anxiety. This suggests an overlap between brain circuitries and neurochemical systems regulating aggression and anxiety. In this review, we will discuss different forms of male aggression, rodent models of excessive aggression, and neurobiological mechanisms underlying male aggression in the context of anxiety. We will summarize our attempts to establish an animal model of high and abnormal aggression using rats selected for high (HAB) vs. low (LAB) anxiety-related behaviour. Briefly, male LAB rats and, to a lesser extent, male HAB rats show high and abnormal forms of aggression compared with non-selected (NAB) rats, making them a suitable animal model for studying excessive aggression in the context of extremes in innate anxiety. In addition, we will discuss differences in the activity of the hypothalamic-pituitary-adrenal axis, brain arginine vasopressin, and the serotonin systems, among others, which contribute to the distinct behavioural phenotypes related to aggression and anxiety. Further investigation of the neurobiological systems in animals with distinct anxiety phenotypes might provide valuable information about the link between excessive aggression and disturbed emotional regulation, which is essential for understanding the social and emotional deficits that are characteristic of many human psychiatric disorders.
Neumann
Inga D
ID
Department of Behavioural and Molecular Neuroendocrinology, University of Regensburg Regensburg, Germany.
Veenema
Alexa H
AH
Beiderbeck
Daniela I
DI
Horm Behav. 1994 Mar;28(1):1-15
8034278
Neuropsychopharmacology. 2003 Feb;28(2):235-43
12589376
Compr Psychiatry. 2000 Nov-Dec;41(6):469-78
11086154
Physiol Zool. 1947 Oct;20(4):373-405
18921409
J Neurosci. 2005 Jul 20;25(29):6807-15
16033890
Behav Biol. 1977 Oct;21(2):197-224
562152
J Am Acad Child Adolesc Psychiatry. 1997 Mar;36(3):307-15
9055510
Physiol Behav. 2009 May 25;97(2):157-70
19250945
Neuropsychopharmacology. 2004 Jan;29(1):1-14
12942143
Behav Genet. 1981 Mar;11(2):115-26
7196726
Horm Behav. 2003 Jan;43(1):197-204
12614650
Horm Behav. 2006 Jun;50(1):118-25
16631757
Science. 1996 Nov 29;274(5292):1527-31
8929413
Psychiatr Clin North Am. 1998 Jun;21(2):293-307
9670227
J Comp Physiol Psychol. 1976 Dec;90(12):1169-83
1033211
Prog Brain Res. 1998;119:3-20
10074777
J Neuroendocrinol. 1997 May;9(5):363-8
9181490
Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8357-62
15923261
Brain Res Bull. 1993;30(1-2):1-6
8420617
Physiol Behav. 1991 Oct;50(4):793-9
1663629
J Soc Psychol. 1996 Feb;136(1):49-56
8851447
Clin Psychol Rev. 1997;17(6):651-65
9336689
Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17139-44
18955705
Horm Behav. 1972 Mar;3(1):71-81
4681737
Psychoneuroendocrinology. 1994;19(5-7):709-21
7938366
J Am Acad Child Adolesc Psychiatry. 1993 Nov;32(6):1217-22
8282667
Neurosci Biobehav Rev. 2006;30(3):319-45
16483890
Prog Neurobiol. 2003 Jun;70(2):83-244
12927745
Physiol Behav. 1999 Apr;66(2):293-302
10336157
Nat Neurosci. 2004 Oct;7(10):1048-54
15452576
J Clin Psychiatry. 2003;64 Suppl 4:26-35
12672262
Nat Neurosci. 2003 Oct;6(10):1100-7
12973355
Behav Genet. 2004 May;34(3):309-18
14990869
Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1476-81
9037078
Pharmacol Biochem Behav. 2006 Feb;83(2):169-74
16504276
Psychoneuroendocrinology. 2007 Jun;32(5):437-50
17433558
Behav Neurosci. 2003 Feb;117(1):38-45
12619906
Brain Res. 1984 Apr 23;298(1):141-5
6722551
J Abnorm Child Psychol. 1991 Aug;19(4):469-78
1757712
Annu Rev Neurosci. 2004;27:193-222
15217331
Psychoneuroendocrinology. 2005 Jul;30(6):550-7
15808924
Neuropsychopharmacology. 1998 Nov;19(5):381-96
9778660
J Clin Psychiatry. 1998;59 Suppl 18:18-22
9840194
Dev Psychobiol. 1991 Dec;24(8):547-58
1773913
Physiol Behav. 1996 Jul;60(1):25-9
8804638
Int Clin Psychopharmacol. 1995 Jan;9 Suppl 4:41-5
7622823
Behav Genet. 2003 Sep;33(5):485-501
14574126
CNS Neurol Disord Drug Targets. 2006 Apr;5(2):167-79
16611090
Eur J Neurosci. 2006 Sep;24(6):1711-20
17004935
Eur J Pharmacol. 2008 Apr 7;583(2-3):340-9
18255056
J Am Acad Child Psychiatry. 1980 Summer;19(3):476-90
7410752
Curr Pharm Des. 2005;11(2):205-25
15638758
Neurosci Biobehav Rev. 2006;30(3):292-303
16483889
Nat Rev Neurosci. 2005 Jun;6(6):463-75
15891777
Fundam Clin Pharmacol. 2007 Dec;21(6):567-74
18034657
Neurosci Biobehav Rev. 2007;31(1):89-102
16934871
Psychoneuroendocrinology. 2009 Apr;34(3):463-7
19056182
Nat Genet. 2000 Apr;24(4):410-4
10742108
J Affect Disord. 1995 Dec 13;35(3):117-23
8749839
Behav Brain Res. 2009 Jul 19;201(1):179-91
19428632
Neuropsychopharmacology. 2002 Jan;26(1):94-105
11751036
J Neurosci Methods. 1985 Aug;14(3):149-67
2864480
Science. 1995 Jun 23;268(5218):1763-6
7792602
Horm Behav. 2010 Jul;58(2):273-81
20298693
Eur J Pharmacol. 2005 Dec 5;526(1-3):207-17
16310769
Psychopharmacology (Berl). 2002 Oct;163(3-4):434-58
12373445
Am J Psychiatry. 2000 Oct;157(10):1629-33
11007717
Behav Brain Res. 2004 Jan 5;148(1-2):185-98
14684259
Horm Behav. 1999 Aug;36(1):25-38
10433884
Physiol Behav. 1997 Mar;61(3):381-5
9089756
Physiol Behav. 2008 Mar 18;93(4-5):807-19
18190935
Behav Neurosci. 2006 Feb;120(1):60-71
16492117
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30;31(1):27-31
16893596
Horm Behav. 1972 Sep;3(3):247-59
4681746
Physiol Behav. 1992 May;51(5):961-8
1319590
Horm Behav. 2003 Sep;44(3):242-57
14609546
Behav Brain Res. 2007 Oct 1;183(1):18-24
17599477
Psychoneuroendocrinology. 2005 Sep;30(8):791-806
15896920
Ann N Y Acad Sci. 1996 Sep 20;794:98-103
8853596
Physiol Behav. 1990 Nov;48(5):693-9
2082369
PLoS One. 2009;4(4):e5129
19357765
Pharmacol Biochem Behav. 1978 Apr;8(4):497-9
566931
Eur J Pharmacol. 2005 Dec 5;526(1-3):51-64
16325649
Brain Res. 1992 Jan 8;569(1):106-11
1611470
Eur J Pharmacol. 2005 Dec 5;526(1-3):21-35
16298361
Behav Genet. 2003 Sep;33(5):563-74
14574133
Front Neuroendocrinol. 2009 Oct;30(4):497-518
19341763
Endocrinology. 2008 Oct;149(10):4892-900
18566122
Biol Psychiatry. 1998 Aug 1;44(3):151-62
9693387
Psychoneuroendocrinology. 2004 Jun;29(5):618-35
15041085
Prog Brain Res. 2008;170:261-76
18655888
Behav Genet. 1996 Sep;26(5):477-88
8917946
Behav Brain Res. 2000 Jun 15;111(1-2):153-63
10840141
Front Neuroendocrinol. 2004 Sep-Dec;25(3-4):150-76
15589267
Pharmacol Biochem Behav. 1980 Aug;13(2):167-70
6106204
Science. 1994 Sep 23;265(5180):1875-8
8091214
J Neurosci. 1997 Jun 1;17(11):4331-40
9151749
Ann N Y Acad Sci. 1994 Nov 30;746:345-59; discussion 359-61
7825889
Eur J Pharmacol. 2005 Dec 5;526(1-3):89-100
16280125
Psychopharmacologia. 1973 May 21;30(2):95-102
4576033
Behav Brain Res. 2002 Oct 17;136(1):227-37
12385809
J Clin Psychiatry. 1992 Oct;53 Suppl:46-51
1385390
Prog Brain Res. 2008;170:3-15
18655867
Pharmacol Biochem Behav. 1989 May;33(1):85-91
2476833
Braz J Psychiatry. 2003 Oct;25(4):231-8
15328550
Anim Behav. 1977 Aug;25(3):654-9
562632
Child Dev. 1987 Aug;58(4):1114-34
3608660
Endocrinology. 2007 Feb;148(2):670-82
17110427
Neurosci Biobehav Rev. 1998;23(2):337-44
9884127
Eur J Neurosci. 2008 Dec;28(11):2299-309
19019199
Behav Neurosci. 2001 Apr;115(2):429-36
11345967
Nature. 1995 Nov 23;378(6555):383-6
7477374
Neuroscience. 2000;95(2):567-75
10658637
J Neurochem. 2005 Mar;92(5):1170-9
15715667
J Neuroendocrinol. 2001 Jan;13(1):102-7
11123520
Biol Psychiatry. 2005 May 1;57(9):953-60
15860334
Behav Genet. 2002 Sep;32(5):301-14
12405513
Soc Psychiatry Psychiatr Epidemiol. 1998 Dec;33 Suppl 1:S13-23
9857775
Neuropharmacology. 2010 Jan;58(1):56-61
19589349
Ann N Y Acad Sci. 1992 Jun 12;652:212-26
1626830
Depress Anxiety. 2000;12 Suppl 1:2-19
11098410
Arch Gen Psychiatry. 1994 Jan;51(1):8-19
8279933
Mol Psychiatry. 2002;7(9):975-84
12399951
Nat Neurosci. 2004 Aug;7(8):847-54
15220929
Psychoneuroendocrinology. 2004 Jan;29(1):35-48
14575728
Arch Gen Psychiatry. 1998 Aug;55(8):708-14
9707381
Physiol Biochem Zool. 2005 Sep-Oct;78(5):679-94
16059845
Science. 1990 Dec 21;250(4988):1678-83
2270481
Prog Neurobiol. 1980;15(3):247-68
7005965
Behav Neurosci. 2008 Aug;122(4):849-54
18729638
Neurobiol Dis. 2009 May;34(2):375-80
19254763
Science. 2000 Jul 28;289(5479):591-4
10915615
Biol Psychiatry. 2002 Jun 15;51(12):936-50
12062877
Brain Res Mol Brain Res. 1993 May;18(3):195-200
8497182
Behav Neurosci. 1999 Aug;113(4):804-15
10495088
Biol Psychiatry. 2001 Jun 15;49(12):1023-39
11430844
Eur J Neurosci. 2010 Mar;31(5):883-91
20374286
Horm Behav. 1991 Jun;25(2):229-41
2066082
Behav Genet. 2003 Sep;33(5):503-11
14574127
Psychopharmacology (Berl). 2001 Dec;158(4):366-73
11797057
Braz J Med Biol Res. 1996 Dec;29(12):1657-62
9222428
Biol Psychol. 1995 Nov 16;41(3):271-93
8608204
Eur J Neurosci. 2006 Jan;23(2):541-51
16420461
Psychoneuroendocrinology. 1983;8(3):343-50
6316393
Exp Clin Psychopharmacol. 2009 Jun;17(3):154-64
19586230
J Neuroendocrinol. 2000 May;12(5):431-6
10792582
Mol Psychiatry. 2009 Apr;14(4):381-9
18283276
Brain Behav Evol. 2007;70(4):274-85
17914259
Physiol Behav. 1991 Mar;49(3):423-6
2062917
J Neuroendocrinol. 2003 Mar;15(3):256-67
12588514
Neuroscience. 2005;132(3):867-77
15837146
Behav Genet. 2009 Jan;39(1):73-90
18972199
Neuropsychopharmacology. 2002 Jun;26(6):729-36
12007743
Horm Behav. 1997 Apr;31(2):136-44
9154434
Neuroreport. 2001 Apr 17;12(5):1035-8
11303741
Ann N Y Acad Sci. 2007 Oct;1113:291-303
17513462
Psychopharmacology (Berl). 2001 Sep;157(3):221-7
11605076
Nat Rev Drug Discov. 2005 Sep;4(9):775-90
16138108
Biol Psychiatry. 2004 Apr 1;55(7):715-23
15039000
Proc Natl Acad Sci U S A. 2000 Oct 24;97(22):12272-7
11027316
Nature. 1996 Oct 10;383(6600):535-8
8849726
Recent Pat CNS Drug Discov. 2008 Jun;3(2):77-93
18537767
Behav Brain Res. 1998 Aug;94(2):301-10
9722280
Behav Neurosci. 2004 Oct;118(5):1062-70
15506888
Nat Neurosci. 2006 Apr;9(4):519-25
16501568
Am Psychol. 1998 Feb;53(2):242-59
9491750
Ann N Y Acad Sci. 1992 Jun 12;652:387-96
1626838
Horm Behav. 2007 Jan;51(1):11-9
16935287
Physiol Behav. 1988;44(2):235-9
2853382
Curr Protoc Neurosci. 2004 May;Chapter 8:Unit 8.3
18428606
Brain Res. 1992 May 8;579(2):321-6
1352729
Eur J Neurosci. 2007 Dec;26(12):3597-605
18052969
J Neurosci. 2004 Sep 1;24(35):7762-70
15342744
Prog Brain Res. 1998;119:395-408
10074802
Science. 1994 Oct 14;266(5183):291-4
7939668
J Neural Transm (Vienna). 1997;104(11-12):1259-66
9503271
Can J Psychiatry. 2006 Feb;51(2):100-13
16989109
Endocrinology. 2003 Jun;144(6):2291-6
12746288
Soc Psychiatry Psychiatr Epidemiol. 1999 May;34(5):231-42
10396164
Behav Brain Res. 2005 Jun 20;161(2):197-203
15922045
Brain Behav Evol. 2001 May;57(5):239-51
11641561
Child Abuse Negl. 2002 Apr;26(4):407-24
12092806
Behav Genet. 2000 Nov;30(6):439-46
11523703
Behav Neurosci. 2003 Aug;117(4):667-74
12931952
Horm Behav. 2003 Sep;44(3):199-208
14609542
Behav Genet. 2001 Jul;31(4):371-82
11720123
Horm Behav. 2003 Sep;44(3):161-70
14609538
Behav Brain Res. 1996 Feb;75(1-2):27-32
8800657
Front Neuroendocrinol. 2004 Sep-Dec;25(3-4):132-49
15589266
Brain Res. 1983 Aug 29;273(2):307-17
6311351
J Neuroendocrinol. 1999 Jun;11(6):405-7
10336720
Bull Exp Biol Med. 2002 Apr;133(4):372-6
12124649
Horm Behav. 2000 Mar;37(2):145-55
10753584
J Exp Biol. 2006 Dec;209(Pt 23):4581-9
17114393
Biol Psychiatry. 2003 Feb 15;53(4):275-83
12586446