A polymorphism in the visfatin gene promoter is related to decreased plasma levels of inflammatory markers in patients with coronary artery disease.
Visfatin, a newly identified proinflammatory adipokine, has been linked to coronary artery disease (CAD). The -1535C>T polymorphism (rs61330082) located in the visfatin gene promoter is reportedly associated with proinflammatory status. However, it is unclear whether this polymorphism correlates with plasma levels of inflammatory markers including visfatin, hs-CRP, IL-6 and TNF-α in CAD patients. The present study was to investigate the potential association of the -1535C>T polymorphism with plasma levels of visfatin, IL-6, C reactive protein (hs-CRP) and TNF-α in patients with CAD. We conducted a hospital based study with 171 CAD patients to examine the association between the -1535C>T polymorphism and plasma levels of visfatin, hs-CRP, IL-6 and TNF-α. Plasma visfatin levels were markedly different between patients with stable angina pectoris (SAP, 11.91 ± 0.70 ng/l) and those with unstable angina pectoris (UAP, 17.49 ± 0.20 ng/l) or acute myocardial infarction (AMI, 16.63 ± 0.22 ng/l; SAP versus UAP or AMI, P < 0.05). Compared with the CC genotype, variant genotypes CT and TT correlated with significantly lower levels of visfatin, hs-CRP, IL-6 and TNF-α in the SAP group (P < 0.05), with lower levels of hs-CRP and IL-6 in the UAP group (P < 0.05), and with lower levels of visfatin in the AMI group (P < 0.05) after adjustment for age, gender, smoking, hypertension, diabetes, dyslipidemia and medication. Our results suggest that the -1535C>T polymorphism is associated with decreased plasma levels of inflammatory markers in CAD patients, reflecting that this polymorphism might provide a useful marker for predicting the development of CAD events.
Wang
Lian-Sheng
LS
Department of Cardiology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, Jiangsu Province, China. drlswang@njmu.edu.cn
Yan
Jian-Jun
JJ
Tang
Na-Ping
NP
Zhu
Jun
J
Wang
Yue-Song
YS
Wang
Qi-Ming
QM
Tang
Jian-Jin
JJ
Wang
Ming-Wei
MW
Jia
En-Zhi
EZ
Yang
Zhi-Jian
ZJ
Huang
Jun
J
D054392:Adipokines / Q000378:metabolism; D000368:Aged; D002097:C-Reactive Protein / Q000235:genetics; D003324:Coronary Artery Disease / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics; D008297:Male; D008875:Middle Aged; D054409:Nicotinamide Phosphoribosyltransferase / Q000097:blood* / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012737:Sex Factors; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D054392:Adipokines; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D054409:Nicotinamide Phosphoribosyltransferase
Circulation. 2008 Jan 29;117(4):e25-146
18086926
Am J Respir Crit Care Med. 2005 Feb 15;171(4):361-70
15579727
Ann Biomed Eng. 1988;16(4):367-77
3177983
Cell Biol Int. 2009 Jan;33(1):19-30
18996492
Clin Chim Acta. 2010 Jan;411(1-2):26-30
19804767
Mol Biol Rep. 2009 May;36(5):889-93
18459066
Diabet Med. 2006 Sep;23(9):967-73
16922702
Science. 2005 Jan 21;307(5708):426-30
15604363
Am J Obstet Gynecol. 2002 Oct;187(4):1051-8
12389004
Circulation. 2006 May 2;113(17):e728-32
16651475
Am J Epidemiol. 2010 Jan 1;171(1):14-23
19955471
Atherosclerosis. 2006 Feb;184(2):425-30
15996671
Cardiovasc Res. 2008 May 1;78(2):356-65
18093986
Endocr J. 2008 Mar;55(1):205-12
18270432
Clin Endocrinol (Oxf). 2009 Aug;71(2):202-7
19178507
Mol Biol Rep. 2009 Apr;36(4):775-80
18401567
Circulation. 2004 Nov 30;110(22):3424-9
15557374
Circulation. 2007 Feb 27;115(8):972-80
17283255
J Mol Med (Berl). 2008 Oct;86(10):1153-61
18600307
J Immunol. 2007 Feb 1;178(3):1748-58
17237424
Clin Endocrinol (Oxf). 2007 Nov;67(5):796-800
17634078
Obesity (Silver Spring). 2006 Dec;14(12):2119-26
17189536
N Engl J Med. 1992 Jan 30;326(5):287-91
1728732
Mol Cell Biol. 1994 Feb;14(2):1431-7
8289818
J Mol Endocrinol. 2001 Apr;26(2):107-17
11241162
N Engl J Med. 2005 Apr 21;352(16):1685-95
15843671
Hemodial Int. 2004 Oct 1;8(4):394-9
19379447
Am J Cardiol. 2006 Dec 4;98(11A):26P-33P
17126677
N Engl J Med. 1992 Jan 23;326(4):242-50
1727977