title: Morphological evaluation of bone defect regeneration after treatment with two different forms of bone substitution materials on the basis of BONITmatrix.
abstract: In the design of biomaterials for therapeutic application the evaluation of cellular/tissue responses play a key role. In this study, the in vivo bone-regenerative capacity and resorption of granular BONITmatrix and a paste-like bone substitution material on the basis of BONITmatrix were investigated in a rat cranial defect model. The results obtained with both biomaterials were compared to each other. For these, the paste-like composite and the granular BONITmatrix were implanted in adult male WOK-W rats, the skulls were harvested after eight weeks, and histopathological examinated. The comparison of the both tested biomaterials showed that the paste-like composite is much better to handle, the resorption of the material and the ossification process is much faster than those of granular BONITmatrix. The amount of newly formed bone was also measured and more bone formation was found in bone defects filled with the paste-like composite compared to those with granular BONITmatrix. The present study showed that both biomaterials could stimulate bone regeneration, but the paste-like composite leads in comparison to granular BONITmatrix to an accelerated more comprehensive bone regeneration.
authors.affiliation: Department of Orthodontics, Preventive and Pediatric Dentistry, Ernst-Moritz-Arndt University Greifswald, Germany. keil@uni-greifswald.de
authors.forename: Ch
authors.initials: Ch
authors.lastname: Kunert-Keil
authors.forename: T
authors.initials: T
authors.lastname: Gredrange
authors.forename: R
authors.initials: R
authors.lastname: Mai
authors.forename: A
authors.initials: A
authors.lastname: Spassov
authors.forename: S
authors.initials: S
authors.lastname: Lucke
authors.forename: T
authors.initials: T
authors.lastname: Klinke
authors.forename: J
authors.initials: J
authors.lastname: Kalukin
authors.forename: B W
authors.initials: BW
authors.lastname: Loster
authors.forename: T
authors.initials: T
authors.lastname: Gredes
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects* / Q000502:physiology; D018786:Bone Substitutes / Q000008:administration & dosage*; D002130:Calcium Phosphates / Q000008:administration & dosage*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008297:Male; D010012:Osteogenesis / Q000187:drug effects / Q000502:physiology; D051381:Rats; D012822:Silicon Dioxide / Q000008:administration & dosage*; D012886:Skull / Q000166:cytology / Q000187:drug effects* / Q000473:pathology*; D016896:Treatment Outcome
chemical_list: C519914:BONITmatrix; D018786:Bone Substitutes; D002130:Calcium Phosphates; D012822:Silicon Dioxide