Low-penetrance susceptibility to hematological malignancy.
There is increasing evidence for inherited genetic susceptibility to cancer, and much of this is thought to be caused by the co-inheritance of multiple low risk alleles. Recent developments have allowed the search for this class of susceptibility allele to be conducted on a genome-wide basis. Here we discuss the impact genome-wide association studies are having on our understanding of two of the major hematological malignancies, chronic lymphocytic leukemia and acute lymphoblastic leukemia.
Houlston
Richard S
RS
Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK. Richard.houlston@icr.ac.uk
D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000379:methods* / Q000639:trends; D019337:Hematologic Neoplasms / Q000235:genetics*; D006801:Humans; D019683:Penetrance; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors