title: Constituents from the testas of Castanea mollissima Blume with alpha-glucosidase inhibitory activity.
abstract: In the screening of biologically active constituents from medicinal plants, the 75% EtOH extract of the testas of Castanea mollissima Blume showed potent alpha-glucosidase inhibitory activity. By means of various chromatographic methods, the extract gave a new dammarane-type triterpene 1 along with 17 known compounds. The structure of 1 was determined to be 3beta-acetoxy-20-oxo-21-nordammaran-23-oic acid by HRMS and NMR studies including 2D NMR experiments. The new compound and some known compounds showed potent alpha-glucosidase inhibitory activity with acarbose as a positive control.
authors.affiliation: School of Traditional Chinese Medicines, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Hui-Yuan
authors.initials: HY
authors.lastname: Gao
authors.forename: Di
authors.initials: D
authors.lastname: Wu
authors.forename: Chuan
authors.initials: C
authors.lastname: Lu
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Xu
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: Bo-Hang
authors.initials: BH
authors.lastname: Sun
authors.forename: Li-Jun
authors.initials: LJ
authors.lastname: Wu
mesh_terms: D029962:Fagaceae / Q000737:chemistry; D065089:Glycoside Hydrolase Inhibitors; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: C549176:3beta-acetoxy-20-oxo-21-nordammaran-23-oic acid; D065089:Glycoside Hydrolase Inhibitors; D014315:Triterpenes