Application of the continuity equation to a breathing motion model.
OBJECTIVE
To quantitatively test a breathing motion model using the continuity equation and clinical data.


METHODS
The continuity equation was applied to a lung tissue and lung tumor free breathing motion model to quantitatively test the model performance. The model used tidal volume and airflow as the independent variables and the ratio of motion to tidal volume and motion to airflow were defined as alpha and beta vector fields, respectively. The continuity equation resulted in a prediction that the volume integral of the divergence of the alpha vector field was 1.11 for all patients. The integral of the divergence of the beta vector field was expected to be zero.


RESULTS
For 35 patients, the alpha vector field prediction was 1.06 +/- 0.14, encompassing the expected value. For the beta vector field prediction, the average value was 0.02 +/- 0.03.


CONCLUSIONS
These results provide quantitative evidence that the breathing motion model yields accurate predictions of breathing dynamics.
Low
Daniel A
DA
Washington University School of Medicine, St. Louis, Missouri 63110, USA. low@wustl.edu
Zhao
Tianyu
T
White
Benjamin
B
Yang
Deshan
D
Mutic
Sasa
S
Noel
Camille E
CE
Bradley
Jeffrey D
JD
Parikh
Parag J
PJ
Lu
Wei
W
D003198:Computer Simulation; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008175:Lung Neoplasms / Q000503:physiopathology*; D008954:Models, Biological; D015656:Respiratory Mechanics
Int J Radiat Oncol Biol Phys. 2005 Nov 1;63(3):921-9
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Med Phys. 2006 Aug;33(8):2964-74
16964875