N-terminal type III secretion signal of enteropathogenic Escherichia coli translocator proteins.
We report that the N terminus of the type III secretion system translocator proteins EspB, EspD, and EspA mediate protein secretion and translocation from wild-type enteropathogenic Escherichia coli and hypersecretion from sepL and sepD mutants. EspA containing the translocation signal of Map and Tir containing the secretion signal of EspA are biologically active.
Munera
Diana
D
Flowers Building, Imperial College, London SW7 2AZ, United Kingdom. g.frankel@imperial.ac.uk.
Crepin
Valerie F
VF
Marches
Olivier
O
Frankel
Gad
G
D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism; D054308:Enteropathogenic Escherichia coli / Q000235:genetics / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism
D001425:Bacterial Outer Membrane Proteins; C087863:EaeB protein, E coli; D029968:Escherichia coli Proteins; C102051:EspA protein, E coli; C474481:EspD protein, E coli; C512346:Map protein, E coli; D011956:Receptors, Cell Surface; C495684:SepD protein, E coli; C416081:SepL protein, E coli; C109287:Tir protein, E coli
Arch Microbiol. 2003 Sep;180(3):218-26
12856107
EMBO J. 1998 Apr 15;17(8):2166-76
9545230
PLoS Pathog. 2009 Apr;5(4):e1000375
19390620
Cell Microbiol. 2009 Feb;11(2):309-22
19046338
Lancet. 1978 May 27;1(8074):1119-22
77415
Ann Med. 2005;37(4):234-49
16019722
Proc Natl Acad Sci U S A. 1995 Feb 28;92(5):1664-8
7878036
Cell Mol Life Sci. 2010 Apr;67(7):1065-75
20043184
J Cell Biol. 2002 Aug 5;158(3):401-8
12163464
Mol Microbiol. 2003 Jan;47(1):209-21
12492865
Gut. 1998 Feb;42(2):200-7
9536944
J Bacteriol. 2004 Aug;186(16):5486-95
15292151
Mol Microbiol. 1996 Apr;20(2):313-23
8733230
J Bacteriol. 2002 Sep;184(17):4699-708
12169593
Mol Microbiol. 1998 Dec;30(5):911-21
9988469
Mol Microbiol. 2004 Jun;52(6):1613-25
15186412
Nature. 2006 Nov 30;444(7119):567-73
17136086
PLoS Pathog. 2009 Apr;5(4):e1000376
19390696
EMBO J. 2007 Jun 20;26(12):3015-24
17510628
J Bacteriol. 2000 Sep;182(18):5225-30
10960109
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5
10829079
J Bacteriol. 2005 Apr;187(8):2881-9
15805534
Mol Microbiol. 2009 Jan;71(2):449-60
19017268
Cell Microbiol. 2004 Dec;6(12):1167-83
15527496
Infect Immun. 1997 Jun;65(6):2211-7
9169753
Infect Immun. 2005 Apr;73(4):2135-46
15784556
Infect Immun. 2005 May;73(5):2573-85
15845459
Cell Host Microbe. 2009 Jun 18;5(6):571-9
19527884
Science. 2005 Oct 28;310(5748):674-6
16254184