title: [Orbital metastases of breast cancer. Radiologic features].
abstract: BACKGROUND
  We reviewed the radiologic features of 15 patients with orbital metastases originating from breast cancer.
  
  
  METHODS
  This was a retrospective consecutive case series. Fifteen consecutive patients with orbital metastases originating from breast carcinoma were identified between March 1997 and September 2008. A retrospective chart review was carried out, and the radiologic findings were reviewed.
  
  
  RESULTS
  The metastases were preseptal in 53%, intraconal in 60%, and both intraconal and extraconal in 33%. Lacrimal gland enlargement was noted in 33%, episcleral space involvement in 33%, bone involvement in 13%, and globe dystopia in 53%. The extraocular muscles were involved in 87%; in 60%, two or more muscles were involved. The medial and lateral rectus muscles were affected in 53% and 47%, respectively, and the inferior and superior rectus muscles in 33%. In 47% one or more radiologic features had not been noted by the radiologist, and in 20% the findings were misinterpreted as an"orbital pseudotumor."
  
  
  CONCLUSIONS
  Orbital metastases originating from breast cancer may present heterogeneously. Orbital imaging most commonly shows unilateral and multifocal involvement of multiple extraocular muscles and intraconal and preseptal areas by an irregular lesion.
authors.affiliation: Department of Oculoplastic and Orbital Surgery, The Rotterdam Eye Hospital, BH Rotterdam.
authors.forename: F
authors.initials: F
authors.lastname: Akda
authors.forename: F
authors.initials: F
authors.lastname: Hafezi
authors.forename: H A G
authors.initials: HA
authors.lastname: Heule-Dieleman
authors.forename: W A
authors.initials: WA
authors.lastname: van den Bosch
authors.forename: G P M
authors.initials: GP
authors.lastname: Luyten
authors.forename: H L J
authors.initials: HL
authors.lastname: Tanghe
authors.forename: D
authors.initials: D
authors.lastname: Paridaens
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology / Q000556:secondary; D002293:Adenocarcinoma, Scirrhous / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003937:Diagnosis, Differential; D005128:Eye Diseases / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009367:Neoplasm Staging; D009915:Orbit / Q000473:pathology; D009918:Orbital Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014786:Vision Disorders / Q000175:diagnosis / Q000473:pathology
references.citation: Arch Ophthalmol. 1971 Jun;85(6):673-5
references.pmid: 5562786
references.citation: Am J Ophthalmol. 1967 Apr;63(4):723-6
references.pmid: 6022244
references.citation: Ophthalmology. 1990 May;97(5):620-4
references.pmid: 2342807
references.citation: Br J Ophthalmol. 1997 May;81(5):386-90
references.pmid: 9227204
references.citation: Orbit. 2003 Mar;22(1):15-24
references.pmid: 12759863
references.citation: Cancer. 1976 Sep;38(3):1326-35
references.pmid: 953971
references.citation: Arch Ophthalmol. 1987 Sep;105(9):1215-9
references.pmid: 3307718
references.citation: Ophthalmology. 1998 Oct;105(10):1897-901
references.pmid: 9787361
references.citation: Jpn J Ophthalmol. 1995;39(1):65-70
references.pmid: 7643486
references.citation: Ophthalmic Plast Reconstr Surg. 2001 Sep;17(5):346-54
references.pmid: 11642491
references.citation: Surv Ophthalmol. 1990 Jul-Aug;35(1):1-24
references.pmid: 2204127
references.citation: Arch Ophthalmol. 1974 Oct;92(4):276-86
references.pmid: 4412321