title: Nucleolar dominance and ribosomal RNA gene silencing.
abstract: Nucleolar dominance is an epigenetic phenomenon that occurs in genetic hybrids and describes the expression of 45S rRNA genes inherited from one progenitor due to the silencing of the other progenitor's rRNA genes. Nucleolar dominance is a manifestation of rRNA gene dosage control, which also occurs in non-hybrids, regulating the number of active rRNA genes according to the cellular demand for ribosomes and protein synthesis. Ribosomal RNA gene silencing involves changes in DNA methylation and histone modifications, but the molecular basis for choosing which genes to silence remains unclear. Recent studies indicate a role for short interfering RNAs (siRNAs) or structured regulatory RNAs in rRNA gene silencing in plants or mammals, respectively, suggesting that RNA may impart specificity to the choice mechanism.
authors.affiliation: Department of Biology, Washington University, St. Louis, MO 63130, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Tucker
authors.forename: Alexa
authors.initials: A
authors.lastname: Vitins
authors.forename: Craig S
authors.initials: CS
authors.lastname: Pikaard
mesh_terms: D000818:Animals; D002466:Cell Nucleolus / Q000235:genetics*; D002843:Chromatin / Q000378:metabolism; D018628:Gene Dosage / Q000235:genetics; D020868:Gene Silencing; D020459:Genes, rRNA / Q000235:genetics*; D006801:Humans; D010944:Plants / Q000235:genetics; D012335:RNA, Ribosomal / Q000235:genetics*
chemical_list: D002843:Chromatin; D012335:RNA, Ribosomal
references.citation: Nat Rev Mol Cell Biol. 2003 Aug;4(8):641-9
references.pmid: 12923526
references.citation: Nat Genet. 2002 Nov;32(3):393-6
references.pmid: 12368916
references.citation: Genes Dev. 2005 Jan 1;19(1):50-64
references.pmid: 15598984
references.citation: EMBO J. 2001 Sep 3;20(17):4892-900
references.pmid: 11532953
references.citation: EMBO J. 1998 Jul 1;17(13):3692-703
references.pmid: 9649439
references.citation: Cell Mol Life Sci. 2007 Jan;64(1):29-49
references.pmid: 17171232
references.citation: Curr Biol. 2002 Jul 9;12(13):1138-44
references.pmid: 12121623
references.citation: PLoS One. 2007 Nov 07;2(11):e1157
references.pmid: 17987131
references.citation: J Biol Chem. 2002 Aug 30;277(35):31577-84
references.pmid: 12080048
references.citation: Curr Opin Genet Dev. 2004 Apr;14(2):210-7
references.pmid: 15196469
references.citation: Annu Rev Cell Dev Biol. 2008;24:131-57
references.pmid: 18616426
references.citation: EMBO Rep. 2008 Aug;9(8):774-80
references.pmid: 18600236
references.citation: EMBO J. 2000 Oct 16;19(20):5473-82
references.pmid: 11032814
references.citation: Nature. 1982 Mar 11;296(5853):173-4
references.pmid: 7063022
references.citation: Nat Rev Genet. 2010 Mar;11(3):204-20
references.pmid: 20142834
references.citation: Biochim Biophys Acta. 2008 Nov;1783(11):2116-23
references.pmid: 18687368
references.citation: Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3442-7
references.pmid: 9096413
references.citation: Nat Rev Mol Cell Biol. 2007 Jul;8(7):574-85
references.pmid: 17519961
references.citation: Nature. 1998 May 28;393(6683):386-9
references.pmid: 9620804
references.citation: Mol Cell. 2000 Nov;6(5):1059-66
references.pmid: 11106745
references.citation: Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14891-6
references.pmid: 9843986
references.citation: Cell. 1984 Aug;38(1):38-44
references.pmid: 6467369
references.citation: Genes Dev. 2006 May 15;20(10):1283-93
references.pmid: 16648464
references.citation: Nat Genet. 1998 Jun;19(2):187-91
references.pmid: 9620779
references.citation: PLoS One. 2008;3(12):e3824
references.pmid: 19048103
references.citation: Mol Cell. 2008 Dec 5;32(5):673-84
references.pmid: 19061642
references.citation: Nat Rev Genet. 2005 May;6(5):410-8
references.pmid: 15818384
references.citation: Genetics. 1999 May;152(1):451-60
references.pmid: 10224274
references.citation: Mol Cell. 2001 Nov;8(5):1063-73
references.pmid: 11741541
references.citation: Nucleic Acids Res. 2004 Aug 03;32(14):4091-9
references.pmid: 15292447
references.citation: Genes Dev. 1997 Aug 15;11(16):2124-36
references.pmid: 9284051
references.citation: Theor Appl Genet. 1995 Aug;91(3):529-33
references.pmid: 24169846
references.citation: Biochim Biophys Acta. 2007 May-Jun;1769(5-6):383-92
references.pmid: 17439825
references.citation: Mol Cell. 2004 Feb 27;13(4):599-609
references.pmid: 14992728
references.citation: Mol Cell Biol. 2004 Feb;24(4):1791-8
references.pmid: 14749393
references.citation: Mol Cell. 2006 May 5;22(3):351-61
references.pmid: 16678107
references.citation: Curr Opin Cell Biol. 2009 Jun;21(3):367-76
references.pmid: 19243928
references.citation: Mol Cell Biol. 2003 Dec;23(23):8862-77
references.pmid: 14612424
references.citation: EMBO Rep. 2010 Jan;11(1):52-8
references.pmid: 20010804
references.citation: Mol Cell Biol. 1984 Feb;4(2):221-7
references.pmid: 6700588
references.citation: Genes Dev. 2003 Jul 15;17(14):1691-702
references.pmid: 12865296
references.citation: Genetics. 2004 Jun;167(2):931-9
references.pmid: 15238541
references.citation: J Cell Biol. 1985 Nov;101(5 Pt 1):2013-6
references.pmid: 3932369
references.citation: Genes Dev. 2006 Jul 15;20(14):1848-67
references.pmid: 16847345
references.citation: Mol Cell Biol. 2005 Apr;25(7):2539-46
references.pmid: 15767661
references.citation: Mol Cell Biol. 2003 Mar;23(5):1558-68
references.pmid: 12588976
references.citation: J Biol Chem. 2002 Jul 26;277(30):27423-32
references.pmid: 12015311
references.citation: Genes Dev. 2006 May 15;20(10):1207-14
references.pmid: 16702398
references.citation: Trends Biochem Sci. 1999 Nov;24(11):437-40
references.pmid: 10542411
references.citation: Hum Mol Genet. 2007 Apr 15;16 Spec No 1:R21-7
references.pmid: 17613545
references.citation: J Mol Biol. 1973 Oct 25;80(2):217-28
references.pmid: 4763983
references.citation: Protoplasma. 2007;232(1-2):55-9
references.pmid: 18157499
references.citation: EMBO J. 2002 Sep 2;21(17):4632-40
references.pmid: 12198165
references.citation: PLoS One. 2007 Aug 29;2(8):e815
references.pmid: 17726545
references.citation: Genes Dev. 2007 Aug 15;21(16):2041-54
references.pmid: 17699751
references.citation: Chromosoma. 2009 Feb;118(1):11-23
references.pmid: 18925405