An efficient deprotection of N-trimethylsilylethoxymethyl (SEM) groups from dinucleosides and dinucleotides.
A convenient and efficient method for deprotection of N-(trimethyl)silylethoxymethyl (SEM) groups from thymidine dinucleoside and dinucleotide has been achieved. The SEM groups were easily removed in excellent yields from protected nucleosides, dinucleosides, and dinucleotides.
Chandra
Tilak
T
Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA.
Broderick
William E
WE
Broderick
Joan B
JB
D002625:Chemistry, Organic / Q000379:methods*; D015226:Dinucleoside Phosphates / Q000737:chemistry*; D004952:Esters / Q000737:chemistry; D017665:Hydroxyl Radical / Q000737:chemistry; D013237:Stereoisomerism; D017971:Tin Compounds / Q000737:chemistry; D014297:Trimethylsilyl Compounds / Q000737:chemistry*
D015226:Dinucleoside Phosphates; D004952:Esters; D017971:Tin Compounds; D014297:Trimethylsilyl Compounds; D017665:Hydroxyl Radical; C041694:stannic chloride
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