Dammarane-type saponins from Gynostemma pentaphyllum.
Dammarane-type saponins, gypenosides VN1-VN7 (1-7), were isolated from the total saponin extract of Gynostemma pentaphyllum aerial parts, with their structures elucidated on the basis of spectroscopic and chemical methods. These compounds showed moderate cytotoxic activity against four human cancer cell lines, A549 (lung), HT-29 (colon), MCF-7 (breast), and SK-OV-3 (ovary), with IC(50) values ranging from 19.6+/-1.1 to 43.1+/-1.0 microM. Regarding the HL-60 (acute promyelocytic leukemia) cell line, compounds 1, 5, and 6 showed weakly active with IC(50) values of 62.8+/-1.9, 72.6+/-3.6, and 82.4+/-3.2 nM, respectively, while 2, 3, 4, and 7 were less active with IC(50) values>100 microM.
Ky
Pham Thanh
PT
Hanoi University of Pharmacy, 17 Le Thanh Tong, Hanoi, Vietnam.
Huong
Pham Thanh
PT
My
Than Kieu
TK
Anh
Pham Tuan
PT
Kiem
Phan Van
PV
Minh
Chau Van
CV
Cuong
Nguyen Xuan
NX
Thao
Nguyen Phuong
NP
Nhiem
Nguyen Xuan
NX
Hyun
Jae-Hee
JH
Kang
Hee-Kyoung
HK
Kim
Young Ho
YH
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D029774:Gynostemma / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014744:Vietnam; D000097669:Dammaranes
D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes; D000097669:Dammaranes