The functional effect of epigallocatechin gallate on ischemic stroke in rats.
We evaluated the efficacy of epigallocatechin gallate (EGCG) for improving function in rats with transient middle cerebral artery occlusion (MCAO). Three procedures underwent for each groups; MCAO and EGCG treatment, MCAO without treatment (MCAO control), and sham operation. Function was evaluated on days 1, 5, 10, and 14 after ischemia, using a modified sticky-tape test and the percentage weight borne on the paretic leg. Infarct volume did not differ between the EGCG-treated and MCAO control groups. Compared with the MCAO control group, the EGCG-treated group showed improved forelimb function and had normal function by day 10 (P<0.05). The improvements persisted until day 14 postischemia. In contrast, hind limb function did not differ between the EGCG-treated and MCAO control groups. Thus, EGCG improved certain aspects of function of forelimb until day 14 after MCAO in rats.
Lim
Seong Hoon
SH
Department of Rehabilitation Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Kim
Han Seung
HS
Kim
Young Kook
YK
Kim
Tae Min
TM
Im
Sun
S
Chung
Myung Eun
ME
Hong
Bo Young
BY
Ko
Young Jin
YJ
Kim
Hye Won
HW
Lee
Jong In
JI
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D020520:Brain Infarction / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D002392:Catechin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004195:Disease Models, Animal; D006614:Hindlimb / Q000503:physiopathology; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D055139:Sensory Gating / Q000187:drug effects; D018709:Statistics, Nonparametric
D018696:Neuroprotective Agents; D002392:Catechin; C045651:epigallocatechin gallate