title: Developmental change in the neurophysiological correlates of self-regulation in high- and low-emotion conditions.
abstract: One of the most important tasks of childhood is learning to self-regulate in the presence of negative emotions. Until recently, almost no research has examined the neurophysiological correlates of emotional self-regulation as it develops over childhood and adolescence. We were interested in plotting a fine-grained developmental profile of the neural underpinnings of self-regulation, in the context of negative emotion, for 7- to 14-year-old children. We predicted that children would recruit less cortical activation with age in the service of self-regulation, reflecting increased neural efficiency with development. We also predicted that children would recruit more cortical activation with increased negative emotion, possibly reflecting greater demand on cortical resources. We administered a Go No-Go task with an emotion induction block and we measured the amplitude of the N2, an event related potential associated with inhibitory control, as it varied with block and with age. Furthermore, we estimated activation for a ventral prefrontal region of interest (ROI; suggestive of orbital frontal, ventromedial prefrontal, or rostral anterior cingulate activation) and a dorsomedial prefrontal ROI (suggestive of dorsal anterior cingulate activation) frequently modeled as cortical generators underlying the N2. Results revealed a marginal decrease in mediofrontal scalp activation, but a more pronounced decrease in activation of the ventromedial prefrontal ROI, with age. There were no age-related changes in dorsomedial prefrontal ROI activation. Lastly, as predicted, we found increased ventral prefrontal ROI activation during the negative emotion induction, possibly reflecting greater recruitment of frontocortical resources underlying emotion regulation, but developmental change in this activation was no different than for the other conditions. Thus, both self-regulation in general and emotion regulation in particular recruited less cortical activation with age, suggesting more efficient cortical mechanisms of response inhibition.
authors.affiliation: Child Development Laboratory, Department of Human Development, University of Maryland, College Park, Maryland 20742, USA. connie.lamm@gmail.com
authors.forename: Connie
authors.initials: C
authors.lastname: Lamm
authors.forename: Marc D
authors.initials: MD
authors.lastname: Lewis
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000704:Analysis of Variance; D001931:Brain Mapping; D002648:Child; D002657:Child Development; D002755:Choice Behavior / Q000502:physiology; D004569:Electroencephalography / Q000379:methods; D004644:Emotions / Q000502:physiology*; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D012927:Social Control, Informal
references.citation: Psychophysiology. 2004 Jan;41(1):157-60
references.pmid: 14693011
references.citation: Neuropsychologia. 2007 Mar 25;45(6):1331-41
references.pmid: 17123557
references.citation: Proc Natl Acad Sci U S A. 2004 May 25;101(21):8174-9
references.pmid: 15148381
references.citation: Nat Neurosci. 2001 Jan;4(1):15-6
references.pmid: 11135639
references.citation: Neuroimage. 2004 Oct;23(2):483-99
references.pmid: 15488398
references.citation: Hum Brain Mapp. 2007 Nov;28(11):1163-77
references.pmid: 17538951
references.citation: Neuroimage. 2001 May;13(5):786-93
references.pmid: 11304075
references.citation: Psychophysiology. 2003 Sep;40(5):752-61
references.pmid: 14696728
references.citation: Arch Gen Psychiatry. 2006 Feb;63(2):184-92
references.pmid: 16461862
references.citation: Am J Phys Anthropol. 1975 Jul;43(1):23-30
references.pmid: 1155589
references.citation: Mol Psychiatry. 2008 Sep;13(9):829, 833-57
references.pmid: 18574483
references.citation: Soc Cogn Affect Neurosci. 2007 Dec;2(4):303-12
references.pmid: 18985136
references.citation: Curr Opin Neurobiol. 2006 Dec;16(6):723-7
references.pmid: 17084617
references.citation: Neuroimage. 2002 May;16(1):61-75
references.pmid: 11969318
references.citation: Cogn Affect Behav Neurosci. 2003 Mar;3(1):17-26
references.pmid: 12822595
references.citation: Biol Psychiatry. 2003 Dec 15;54(12):1345-54
references.pmid: 14675798
references.citation: Neuroimage. 2005 Jun;26(2):471-9
references.pmid: 15907304
references.citation: Nat Neurosci. 2005 Jun;8(6):828-34
references.pmid: 15880108
references.citation: Eur J Neurosci. 2006 Mar;23(6):1658-64
references.pmid: 16553630
references.citation: Prog Brain Res. 1996;107:523-36
references.pmid: 8782540
references.citation: Brain Res Cogn Brain Res. 2005 Feb;22(2):221-31
references.pmid: 15653295
references.citation: Neuropsychologia. 2007 Mar 25;45(6):1270-9
references.pmid: 17118409
references.citation: Neuropsychologia. 2006;44(3):384-95
references.pmid: 16095637
references.citation: Hum Brain Mapp. 2006 Nov;27(11):848-63
references.pmid: 16421886
references.citation: Nat Neurosci. 1999 Oct;2(10):861-3
references.pmid: 10491603
references.citation: Child Dev. 2001 Jan-Feb;72(1):1-21
references.pmid: 11280472
references.citation: Biol Psychiatry. 2006 Nov 15;60(10):1062-70
references.pmid: 16712804
references.citation: Eur J Neurosci. 2004 Nov;20(9):2483-8
references.pmid: 15525290
references.citation: J Cogn Neurosci. 1997 Nov;9(6):835-47
references.pmid: 23964603
references.citation: Dev Psychopathol. 2002 Summer;14(3):477-98
references.pmid: 12349870
references.citation: Hum Brain Mapp. 2006 Dec;27(12):973-93
references.pmid: 16683265
references.citation: Neuroimage. 2003 Oct;20(2):737-51
references.pmid: 14568448
references.citation: J Am Acad Child Adolesc Psychiatry. 2002 Oct;41(10):1231-8
references.pmid: 12364845
references.citation: J Neurosci. 1992 Sep;12(9):3628-41
references.pmid: 1527602
references.citation: Hum Brain Mapp. 1998;6(4):270-82
references.pmid: 9704265
references.citation: Clin Neurophysiol. 1999 Jun;110(6):1149-55
references.pmid: 10402104
references.citation: J Cogn Neurosci. 2006 Mar;18(3):430-43
references.pmid: 16513007
references.citation: Biol Psychiatry. 2003 Sep 1;54(5):504-14
references.pmid: 12946879
references.citation: Dev Psychopathol. 2007 Spring;19(2):455-80
references.pmid: 17459179
references.citation: Cereb Cortex. 2000 Mar;10(3):284-94
references.pmid: 10731223
references.citation: Biol Psychol. 2005 Oct;70(2):79-87
references.pmid: 16168252
references.citation: Hum Brain Mapp. 2001 Feb;12(2):100-9
references.pmid: 11169874
references.citation: Psychophysiology. 2005 Jan;42(1):33-42
references.pmid: 15720579
references.citation: Dev Sci. 2007 Nov;10(6):874-91
references.pmid: 17973802
references.citation: Neurosci Biobehav Rev. 2002 Oct;26(6):631-64
references.pmid: 12479840
references.citation: Brain Cogn. 2004 Nov;56(2):165-76
references.pmid: 15518933
references.citation: Trends Cogn Sci. 2000 Jun;4(6):215-222
references.pmid: 10827444
references.citation: Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8301-6
references.pmid: 10393989
references.citation: Neuropsychologia. 2006;44(11):2139-48
references.pmid: 16310813
references.citation: Neuroimage. 2003 Sep;20(1):420-8
references.pmid: 14527602
references.citation: Trends Cogn Sci. 2004 Dec;8(12):539-46
references.pmid: 15556023
references.citation: Schizophr Res. 2007 Dec;97(1-3):184-93
references.pmid: 17855057
references.citation: J Am Acad Child Adolesc Psychiatry. 1998 Sep;37(9):977-85
references.pmid: 9735617
references.citation: Brain Res. 2006 Feb 23;1075(1):151-64
references.pmid: 16458860
references.citation: Child Dev. 2001 Jul-Aug;72(4):1091-111
references.pmid: 11480936
references.citation: Biol Psychiatry. 1998 Dec 15;44(12):1219-28
references.pmid: 9861465
references.citation: Brain Cogn. 2006 Nov;62(2):98-112
references.pmid: 16814442
references.citation: Clin Neurophysiol. 2007 May;118(5):1069-77
references.pmid: 17368096
references.citation: Clin Neurophysiol. 2001 Dec;112(12):2224-32
references.pmid: 11738192
references.citation: Biol Psychol. 2000 Oct;54(1-3):241-57
references.pmid: 11035225
references.citation: Clin Neurophysiol. 2004 Sep;115(9):2001-13
references.pmid: 15294202
references.citation: J Cogn Neurosci. 2006 May;18(5):766-80
references.pmid: 16768376
references.citation: Biol Psychiatry. 2008 May 15;63(10):927-34
references.pmid: 18452757
references.citation: Acta Psychol (Amst). 1999 Apr;101(2-3):267-91
references.pmid: 10344188
references.citation: J Neurosci. 2008 Apr 2;28(14):3586-94
references.pmid: 18385317
references.citation: Science. 2004 Feb 13;303(5660):1023-6
references.pmid: 14963333
references.citation: Clin Neurophysiol. 2004 Oct;115(10):2195-222
references.pmid: 15351361
references.citation: Clin Neurophysiol. 2004 Jun;115(6):1320-31
references.pmid: 15134699
references.citation: Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1944-8
references.pmid: 10677559
references.citation: J Am Acad Child Adolesc Psychiatry. 2004 Nov;43(11):1430-40
references.pmid: 15502603
references.citation: Neuroimage. 1998 Jul;8(1):62-8
references.pmid: 9698576
references.citation: Brain. 1999 May;122 ( Pt 5):981-91
references.pmid: 10355680