Analyses of left ventricular myocardial deformation by speckle-tracking imaging during the acute phase of Kawasaki disease.
This study aimed to investigate left ventricular myocardial deformation in children with Kawasaki disease during the acute phase of their illness. A total of 50 patients and 35 normal control subjects were assessed. Data were obtained from the patients during the acute and convalescent phases of Kawasaki disease. Analyses of myocardial deformation [strain (epsilon), strain rate (SR)] was performed using two-dimensional speckle-tracking imaging in three directions (longitudinal, circumferential, and radial) at the basal and mid levels of the left ventricular myocardium. Basal longitudinal epsilon (P < 0.001) and midlongitudinal epsilon (P < 0.0001) were lower during the acute phase of the disease than in the control subjects and associated with serum albumin level and left ventricular mass index (LVMI). Midlongitudinal SR (P < 0.0001) was lower during the acute phase of Kawasaki disease than in the control subjects and associated with LVMI. Decreased systolic SR was not detected in any direction. In conclusion, left ventricular longitudinal systolic epsilon was significantly decreased during the acute phase of Kawasaki disease. This may be a result of myocardial swelling from myocarditis during the acute phase of the disease.
Yu
Jeong Jin
JJ
Division of Pediatric Cardiology, Asan Medical Center, College of Medicine, University of Ulsan, 388-1 Pungnap-2dong, Songpa-gu, Seoul 138-736, South Korea. pediatrist@medimail.co.kr
Choi
Hyung Soon
HS
Kim
Yong Beom
YB
Son
Jae Sung
JS
Kim
Young-Hwue
YH
Ko
Jae-Kon
JK
Park
In-Sook
IS
D000208:Acute Disease; D002675:Child, Preschool; D018450:Disease Progression; D015150:Echocardiography, Doppler / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006325:Heart Atria / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications / Q000000981:diagnostic imaging*; D009200:Myocardial Contraction / Q000502:physiology*; D009205:Myocarditis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D011379:Prognosis; D015203:Reproducibility of Results; D012189:Retrospective Studies
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