Serotonin 6 receptor gene and mood disorders: case-control study and meta-analysis.
Several evidence suggests that alterations in serotonin 6 (5-HT6) receptors might be associated with the pathophysiology of mood disorders. Therefore, to evaluate the association between HTR6 and BP and MDD, we conducted a case-control study of Japanese population samples (1007 BP patients, 447 MDD patients and 1753 controls) with five tagging SNPs, including rs1805054 (C267T), in HTR6. In addition, we conducted a meta-analysis of rs1805054, which has been examined in other studies. We selected five tagging SNPs (rs6693503, rs1805054, rs4912138, rs3790757 and rs9659997). Moreover, three association studies for BP and four association studies for MDD, including this study, met our criteria for the meta-analysis of rs1805054. We did not detect an association between tagging SNPs in HTR6 and BP and MDD in the allele/genotype, haplotype analysis or meta-analysis. In conclusion, we found no association involving polymorphism and mood disorder in the Japanese population. However, because changes in expression level or signal transduction of this receptor may be involved in the pathology of these diseases, it will be necessary to conduct the further study about the relationship between this receptor and mood disorders in the future.
Fukuo
Yasuhisa
Y
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Aichi 470 1192, Japan.
Kishi
Taro
T
Yoshimura
Reiji
R
Kitajima
Tsuyoshi
T
Okochi
Tomo
T
Yamanouchi
Yoshio
Y
Kinoshita
Yoko
Y
Kawashima
Kunihiro
K
Naitoh
Hiroshi
H
Umene-Nakano
Wakako
W
Inada
Toshiya
T
Kunugi
Hiroshi
H
Kato
Tadafumi
T
Yoshikawa
Takeo
T
Ujike
Hiroshi
H
Nakamura
Jun
J
Ozaki
Norio
N
Iwata
Nakao
N
D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics / Q000523:psychology; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000235:genetics / Q000523:psychology; D005260:Female; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000235:genetics* / Q000523:psychology*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011985:Receptors, Serotonin / Q000235:genetics*; D018401:Sample Size
D011985:Receptors, Serotonin; C097216:serotonin 6 receptor