title: Neurocognitive functioning in women with a history of eclampsia: executive functioning and sustained attention.
abstract: Recently, information has emerged that formerly eclamptic women may suffer cognitive impairment. This may be related to cerebral white matter lesions. The few available reports demonstrate inconsistent results. We sought to elucidate cognitive performance after eclampsia in a pilot study. Twenty-six eclamptic, 20 preeclamptic, and 18 healthy parous women performed the Sustained Attention to Response Task (SART; the ability to sustain mindful processing of repetitive stimuli that would otherwise lead to habituation) and the Random Number Generation Task (RNG; executive functioning, i.e., inhibition and updating/monitoring). Average age was 40 years, elapsed time since index pregnancy was 9 years. Education levels did not differ. There were no intercurrent illnesses. No significant differences were found on SART and RNG scores between groups. This study was not able to demonstrate evidence for impaired sustained attention and executive functioning after eclampsia. Studies including a much wider range of neurocognitive tests amplified to posterior brain regions with larger groups are necessary.
authors.affiliation: Department of Obstetrics and Gynecology, University Medical Center Groningen, Groningen, The Netherlands.
authors.forename: Ineke R
authors.initials: IR
authors.lastname: Postma
authors.forename: Ineke
authors.initials: I
authors.lastname: Wessel
authors.forename: Jan G
authors.initials: JG
authors.lastname: Aarnoudse
authors.forename: Gerda G
authors.initials: GG
authors.lastname: Zeeman
mesh_terms: D000328:Adult; D001288:Attention; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D003071:Cognition / Q000502:physiology*; D004461:Eclampsia / Q000473:pathology / Q000503:physiopathology / Q000523:psychology*; D056344:Executive Function; D005260:Female; D006801:Humans; D008875:Middle Aged; D009483:Neuropsychological Tests; D010865:Pilot Projects; D011247:Pregnancy