[Antimicrobic features of phenolic lipids].
The connection between the efficiency of phenolic lipids (PL) and their hydrophobic property (solubility) and hydrophobic property of microorganisms' cell structure is shown. The mixture of amphiphilic di(oxiphenil)-phenil-methanes, which act bacteriostatically under 15 mg/l, possesses maximal efficiency against Staphylococcus aureus. Against Mycobacterium smegmatis with hydrophobic cell wall, hydrophobic 2,4-dialkylocibenzol 70 mg/l was the most effective. Hexylresorcin (HR) stops the development of gram-positive bacteria in concentrations 20-50 mg/l, that of gram-negative bacteria in concentration 65 mg/l, that of M. smegmatis at 70 mg/l, and that of yeast and fungi at 300 mg/l. HR prevails bacteria spores germination in the concentration 25-100 mg/l. The dependence of antibacterial action of isomers and homologues of alkylresorcins on their structure--number, position, and length of alkyl substituents--is studied.
Nikolaev
Iu A
IuA
Borzenkov
I A
IA
Kalinin
M V
MV
Loĭko
N G
NG
Tarasov
A L
AL
Plakunov
V K
VK
Beliaev
S S
SS
Voronina
N V
NV
Gal'chenko
V F
VF
El'-Registan
G I
GI
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002473:Cell Wall / Q000737:chemistry; D005658:Fungi / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008055:Lipids / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D020102:Mycobacterium smegmatis / Q000187:drug effects; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology*; D012118:Resorcinols / Q000737:chemistry / Q000494:pharmacology; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D008055:Lipids; D010636:Phenols; D012118:Resorcinols