Regional homogeneity of fMRI time series in autism spectrum disorders.
Functional magnetic resonance imaging (fMRI) and functional connectivity MRI (fcMRI) studies of autism spectrum disorders (ASD) have suggested atypical patterns of activation and long-distance connectivity for diverse tasks and networks in ASD. We explored the regional homogeneity (ReHo) approach in ASD, which is analogous to conventional fcMRI, but focuses on local connectivity. FMRI data of 26 children with ASD and 29 typically developing (TD) children were acquired during continuous task performance (visual search). Effects of motion and task were removed and Kendall's coefficient of concordance (KCC) was computed, based on the correlation of the blood oxygen level dependent (BOLD) time series for each voxel and its six nearest neighbors. ReHo was lower in the ASD than the TD group in superior parietal and anterior prefrontal regions. Inverse effects of greater ReHo in the ASD group were detected in lateral and medial temporal regions, predominantly in the right hemisphere. Our findings suggest that ReHo is a sensitive measure for detecting cortical abnormalities in autism. However, impact of methodological factors (such as spatial resolution) on ReHo require further investigation.
Shukla
Dinesh K
DK
Brain Development Imaging Laboratory, Department of Psychology, San Diego State University, San Diego, CA 92120, United States.
Keehn
Brandon
B
Müller
Ralph Axel
RA
D000293:Adolescent; D001921:Brain / Q000098:blood supply / Q000503:physiopathology; D016022:Case-Control Studies; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010100:Oxygen / Q000097:blood
D010100:Oxygen
Brain. 1998 May;121 ( Pt 5):889-905
9619192
Philos Trans R Soc Lond B Biol Sci. 2009 May 27;364(1522):1433-6
19528027
Neuroimage. 2008 Feb 15;39(4):1877-85
18083565
Trends Cogn Sci. 2004 Jan;8(1):26-32
14697400
Acta Neuropathol. 2006 Sep;112(3):287-303
16819561
Brain Res. 2010 Mar 19;1321:169-79
20053346
Int J Psychophysiol. 2007 Feb;63(2):164-72
16820239
Proc Natl Acad Sci U S A. 2000 May 9;97(10):5039-43
10805766
Hum Brain Mapp. 2005 Jan;24(1):59-68
15382248
Nat Rev Neurosci. 2004 Mar;5(3):184-94
14976518
J Int Neuropsychol Soc. 2008 Nov;14(6):990-1003
18954479
Neuroimage. 2004 May;22(1):394-400
15110032
Hum Brain Mapp. 2009 May;30(5):1502-10
18649351
J Affect Disord. 2009 Jun;115(3):430-8
19007997
Neuroimage. 2007 Apr 1;35(2):488-500
17254803
Clin EEG Neurosci. 2005 Jan;36(1):15-20
15683193
Neurology. 2002 Feb 12;58(3):428-32
11839843
Am J Psychiatry. 1995 Feb;152(2):248-52
7840359
J Child Psychol Psychiatry. 2007 Dec;48(12):1251-8
18093031
Ment Retard Dev Disabil Res Rev. 2004;10(4):303-17
15666334
Neuroimage. 2002 Aug;16(4):1038-51
12202091
Mol Psychiatry. 2004 Jul;9(7):646-63
15037868
Neuroimage. 2007 Mar;35(1):396-405
17239622
Neurosci Lett. 2007 Aug 23;423(3):189-93
17709202
Neuropsychobiology. 2004;49(3):115-25
15034226
Science. 2007 Jul 6;317(5834):43; author reply 43
17615325
J Cogn Neurosci. 1994 Summer;6(3):220-32
23964973
Neuroreport. 2006 Jul 17;17(10):1033-6
16791098
Comput Biomed Res. 1996 Jun;29(3):162-73
8812068
Biol Psychiatry. 2007 Aug 1;62(3):270-3
17336944
Brain. 1997 Apr;120 ( Pt 4):701-22
9153131
Dev Neuropsychol. 2005;27(3):425-58
15843105
Cereb Cortex. 2008 Nov;18(11):2659-65
18359780
Ann Neurol. 2004 Apr;55(4):530-40
15048892
Int J Dev Neurosci. 2005 Apr-May;23(2-3):153-70
15749242
Nat Rev Neurosci. 2007 Sep;8(9):700-11
17704812
Neuroimage. 2009 Aug 15;47(2):764-72
19409498
Proc Natl Acad Sci U S A. 2009 Jun 30;106(26):10841-6
19541656
Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):253-8
12506194
Brain Res. 2007 Aug 8;1162:85-97
17612510
Acta Psychiatr Scand. 2000 Nov;102(5):321-30
11098802
Neuroimage. 2008 Mar 1;40(1):110-20
18191584
Neuroreport. 2006 Jan 23;17(1):19-22
16361943
Genes Brain Behav. 2003 Oct;2(5):255-67
14606691