title: A study of the efficacy of cleansers for acne vulgaris.
abstract: BACKGROUND
  Acne treatments are sometimes expensive, and mild acne patients need some simpler form of treatment and, thus, the need for easier and cheaper ways of managing acne is increasing.
  
  
  METHODS
  An 8-week, double-blind, randomized clinical trial was conducted to determine whether cleansers are effective at producing clinical improvements in patients with acne vulgaris. A total of 13 acne patients applied cleanser A to one half of the face and cleanser B (cleanser A plus triclosan, salicylic acid, and azelaic acid) to the other half, twice daily.
  
  
  RESULTS
  The numbers of inflammatory and non-inflammatory lesions decreased on both sides. A rebound tendency was noted for cleanser A with respect to inflammatory lesions at 4 weeks post-discontinuation, whereas inflammatory lesions continued to decrease on sides treated with cleanser B during this period. However, non-inflammatory lesion counts were not significantly different in the two groups. Though patients were generally satisfied with both treatments, they were more satisfied with cleanser B. Moreover, histopathologic examinations showed a profound decrease in inflammatory reactions in the cleanser B group.
  
  
  CONCLUSIONS
  These results show that acne cleansers reduced both inflammatory and non-inflammatory acne lesion counts, and might be helpful for acne treatment.
authors.affiliation: Department of Dermatology, Ulsan University Hospital, Ulsan, Korea.
authors.forename: Yu Sung
authors.initials: YS
authors.lastname: Choi
authors.forename: Ho Seok
authors.initials: HS
authors.lastname: Suh
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Yoon
authors.forename: Seong Uk
authors.initials: SU
authors.lastname: Min
authors.forename: Jin Sook
authors.initials: JS
authors.lastname: Kim
authors.forename: Jae Yoon
authors.initials: JY
authors.lastname: Jung
authors.forename: Dong Hun
authors.initials: DH
authors.lastname: Lee
authors.forename: Dae Hun
authors.initials: DH
authors.lastname: Suh
mesh_terms: D000152:Acne Vulgaris / Q000175:diagnosis* / Q000188:drug therapy*; D000279:Administration, Cutaneous; D000328:Adult; D003902:Detergents / Q000627:therapeutic use*; D003998:Dicarboxylic Acids; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010206:Papain / Q000627:therapeutic use; D017060:Patient Satisfaction; D011336:Probability; D020156:Salicylic Acid / Q000627:therapeutic use; D012720:Severity of Illness Index; D012869:Skin Absorption / Q000187:drug effects; D017592:Skin Care / Q000379:methods*; D018709:Statistics, Nonparametric; D016896:Treatment Outcome; D014260:Triclosan / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D003902:Detergents; D003998:Dicarboxylic Acids; D014260:Triclosan; D010206:Papain; C010038:azelaic acid; D020156:Salicylic Acid