title: AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4.
abstract: A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4(+) T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.
authors.affiliation: Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. agarci5@emory.edu
authors.forename: Anapatricia
authors.initials: A
authors.lastname: García
authors.forename: Nagadenahalli B
authors.initials: NB
authors.lastname: Siddappa
authors.forename: Qingsheng
authors.initials: Q
authors.lastname: Li
authors.forename: Ashley T
authors.initials: AT
authors.lastname: Haase
authors.forename: Katherine
authors.initials: K
authors.lastname: Paul
authors.forename: Fawn
authors.initials: F
authors.lastname: Stroud
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Zhang
authors.forename: Jack A
authors.initials: JA
authors.lastname: Fountain
authors.forename: François
authors.initials: F
authors.lastname: Villinger
authors.forename: Francis J
authors.initials: FJ
authors.lastname: Novembre
authors.forename: James G
authors.initials: JG
authors.lastname: Else
authors.forename: W
authors.initials: W
authors.lastname: Evan Secor
authors.forename: Ruth M
authors.initials: RM
authors.lastname: Ruprecht
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000662:veterinary / Q000821:virology; D000818:Animals; D005260:Female; D015497:HIV-1 / Q000235:genetics*; D008253:Macaca mulatta; D008992:Monkey Diseases / Q000821:virology*; D009902:Optic Neuritis / Q000662:veterinary* / Q000821:virology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000235:genetics*; D014766:Viremia
references.citation: J Leukoc Biol. 2006 Nov;80(5):965-72
references.pmid: 16923919
references.citation: J Clin Virol. 2008 Mar;41(3):180-5
references.pmid: 18164651
references.citation: Br J Ophthalmol. 2000 May;84(5):551-3
references.pmid: 10847713
references.citation: PLoS Negl Trop Dis. 2008 Jul 23;2(7):e265
references.pmid: 18648516
references.citation: Science. 1999 Nov 12;286(5443):1353-7
references.pmid: 10558989
references.citation: J Virol. 2009 Feb;83(3):1422-32
references.pmid: 19019970
references.citation: Retrovirology. 2008 Oct 17;5:94
references.pmid: 18928523
references.citation: J Neurovirol. 2008 Aug;14(4):309-17
references.pmid: 18780232
references.citation: J Neurovirol. 2008 Aug;14(4):292-300
references.pmid: 18780230
references.citation: J Neurovirol. 2008 Aug;14(4):318-26
references.pmid: 18780233
references.citation: AIDS. 2006 Nov 14;20(17):2135-40
references.pmid: 17086052
references.citation: J Virol. 2006 Sep;80(17):8729-38
references.pmid: 16912320