title: Targeting TLR/IL-1R signalling in human diseases.
abstract: The members of Toll-like receptor/interleukin (IL)-1 receptor (TLR/IL-1R) superfamily play a fundamental role in the immune response. These receptors detect microbial components and trigger complex signalling pathways that result in increased expression of multiple inflammatory genes. On the other hand, an aberrant activation of TLR/IL-1R signalling can promote the onset of inflammatory and autoimmune diseases, raising the interest in the development of therapeutic strategies for the control of their function. In this review, we illustrate the structural and functional features of TLR/IL-1R proteins and discuss some recent advances in the approaches undertaken to develop anti-inflammatory therapeutic drugs. In particular, we will focus on inhibitors, such as decoy peptides and synthetic mimetics, that interfere with protein-protein interactions between signalling molecules of the TLR/IL-1R superfamily. Given their central role in innate and adaptive immune responses, it is foreseen that pharmaceutical modulation of TLR/IL-1R signalling pathways by these drugs might yield clinical benefits in the treatment of inflammatory and autoimmune diseases.
authors.affiliation: Department of Public Health and Cell Biology, University of Rome "Tor Vergata", 00133 Rome, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Loiarro
authors.forename: Vito
authors.initials: V
authors.lastname: Ruggiero
authors.forename: Claudio
authors.initials: C
authors.lastname: Sette
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004194:Disease; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015394:Molecular Structure; D053594:Myeloid Differentiation Factor 88 / Q000235:genetics / Q000378:metabolism; D010455:Peptides / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011487:Protein Conformation; D017472:Receptors, Interleukin-1 / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000737:chemistry / Q000235:genetics / Q000276:immunology*
chemical_list: D053594:Myeloid Differentiation Factor 88; D010455:Peptides; D017472:Receptors, Interleukin-1; D051193:Toll-Like Receptors
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