title: Metastasis of high grade renal cell carcinoma, clear cell type, in fibrous dysplasia with superimposed giant cell reparative granuloma.
abstract: A case of monostotic fibrous dysplasia in a 54-year-old male complaining of severe pain in the right hip is presented. Imaging findings demonstrated an extremely aggressive lesion involving bones, liver, lungs, and lymph nodes, and suggested the possibility of sarcomatous transformation. Histological examination established a diagnosis of metastatic high-grade renal carcinoma, clear cell type, and demonstrated the presence of superimposed giant cell reparative granuloma. This latter is a rare example of giant cell reparative granuloma arising in a long bone and in association with fibrous dysplasia. The clinical, radiographic, and histopathologic features of fibrous dysplasia and giant cell reparative granuloma are discussed.
authors.affiliation: Department of Pathology and Forensic Medicine, University of Trieste, Unit of Pathology, ASS n.2 Isontina, Gorizia, Italy. crizzardi@units.it
authors.forename: C
authors.initials: C
authors.lastname: Rizzardi
authors.forename: M
authors.initials: M
authors.lastname: Schneider
authors.forename: E
authors.initials: E
authors.lastname: Barresi
authors.forename: A
authors.initials: A
authors.lastname: Brollo
authors.forename: M
authors.initials: M
authors.lastname: Melato
mesh_terms: D001859:Bone Neoplasms / Q000556:secondary*; D002292:Carcinoma, Renal Cell / Q000556:secondary*; D005358:Fibrous Dysplasia, Monostotic / Q000150:complications / Q000473:pathology*; D006101:Granuloma, Giant Cell / Q000150:complications / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D014057:Tomography, X-Ray Computed