Evidence of drug confinement into silica mesoporous matrices by STEM spherical aberration corrected microscopy.
For the first time it has been possible to detect drug molecules confined into the inner part of pore channels of ordered mesoporous materials. This has been possible using spherical aberration correctors incorporated to a STEM microscope, which allows illuminating an individual atom with the electron beam to identify an unknown substance.
Vallet-Regí
María
M
Departamento de Química Inorgánica y Bioinorgánica, Facultad de Farmacia, Universidad Complutense de Madrid, 28040, Spain. vallet@farm.ucm.es
Manzano
Miguel
M
González-Calbet
José M
JM
Okunishi
Eiji
E
D004164:Diphosphonates / Q000737:chemistry; D007093:Imidazoles / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*; D000077211:Zoledronic Acid
D004164:Diphosphonates; D007093:Imidazoles; D004364:Pharmaceutical Preparations; C509969:SBA-15; D000077211:Zoledronic Acid; D012822:Silicon Dioxide