title: Immunogenicity of a modified-live virus vaccine against bovine viral diarrhea virus types 1 and 2, infectious bovine rhinotracheitis virus, bovine parainfluenza-3 virus, and bovine respiratory syncytial virus when administered intranasally in young calves.
abstract: The immunogenicity of an intranasally-administered modified-live virus (MLV) vaccine in 3-8 day old calves was evaluated against bovine viral diarrhea virus (BVDV) types 1 and 2, infectious bovine rhinotracheitis (IBR) virus, parainfluenza-3 (PI-3) virus and bovine respiratory syncytial virus (BRSV). Calves were intranasally vaccinated with a single dose of a multivalent MLV vaccine and were challenged with one of the respective viruses three to four weeks post-vaccination in five separate studies. There was significant sparing of diseases in calves intranasally vaccinated with the MLV vaccine, as indicated by significantly fewer clinical signs, lower rectal temperatures, reduced viral shedding, greater white blood cell and platelet counts, and less severe pulmonary lesions than control animals. This was the first MLV combination vaccine to demonstrate efficacy against BVDV types 1 and 2, IBR, PI-3 and BRSV in calves 3-8 days of age.
authors.affiliation: Intervet/Schering-Plough Animal Health, 35500 W. 91st Street, DeSoto, KS 66018, USA. wenzhi.xue@spcorp.com
authors.forename: Wenzhi
authors.initials: W
authors.lastname: Xue
authors.forename: John
authors.initials: J
authors.lastname: Ellis
authors.forename: Debra
authors.initials: D
authors.lastname: Mattick
authors.forename: Linda
authors.initials: L
authors.lastname: Smith
authors.forename: Ryan
authors.initials: R
authors.lastname: Brady
authors.forename: Emilio
authors.initials: E
authors.lastname: Trigo
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000831:Animals, Newborn; D057134:Antibodies, Neutralizing / Q000097:blood; D000914:Antibodies, Viral / Q000097:blood; D000917:Antibody Formation; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000276:immunology / Q000517:prevention & control*; D002417:Cattle; D030241:Diarrhea Virus 1, Bovine Viral / Q000276:immunology; D030242:Diarrhea Virus 2, Bovine Viral / Q000276:immunology; D007242:Herpesvirus 1, Bovine / Q000276:immunology; D007241:Infectious Bovine Rhinotracheitis / Q000276:immunology / Q000517:prevention & control*; D009500:Neutralization Tests; D029101:Parainfluenza Virus 3, Bovine / Q000276:immunology; D018357:Respiratory Syncytial Virus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D018112:Respiratory Syncytial Virus, Bovine / Q000276:immunology; D010253:Respirovirus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D017778:Vaccines, Combined / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*; D017201:Virus Shedding
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D017778:Vaccines, Combined; D014765:Viral Vaccines