title: [Analysis of risk factors for low bone mineral density in patients with inflammatory bowel disease].
abstract: OBJECTIVE
  Several clinical risk factors for low bone mineral density (BMD) in the patients with inflammatory bowel disease (IBD) have been suggested. However, its prevalence and pathophysiology in Korean population have not been fully studied. The aim of this study was to investigate the prevalence and risk factors for low BMD in Korean IBD patient.
  
  
  METHODS
  BMD of the lumbar spine and femur was evaluated using dual-energy X-ray absorptiometry in 30 patients with IBD. Biochemical parameters of bone metabolism, such as serum calcium, phosphorus, osteocalcin, and deoxypyridinoline were measured. The associations between low BMD and clinical parameters such as disease duration, disease activity, drug history, body mass index (BMI), and others were evaluated retrospectively using medical records.
  
  
  RESULTS
  Low BMD at the lumbar spine or femur was observed in 63.3% of the patients, and there was no significant difference between the patients with Crohns disease and ulcerative colitis. Clinical and biochemical parameters were irrelevant to BMD. In the patients without glucocorticoid treatment prior to BMD measurement, already 50.0% of patients had low BMD.
  
  
  CONCLUSIONS
  Low BMD is a common feature in Korean IBD patients, even those who do not use glucocorticoid. The multiple factors may be involved in the pathogenesis of low BMD. Therefore, BMD should be examined in all IBD patients, irrespective of glucocorticoid treatment.
authors.affiliation: Department of Internal Medicine, Ewha Womans University School of Medicine, Ewha Medical Research Institute, Seoul, Korea.
authors.forename: Jae Jung
authors.initials: JJ
authors.lastname: Park
authors.forename: Sung Ae
authors.initials: SA
authors.lastname: Jung
authors.forename: Young Wook
authors.initials: YW
authors.lastname: Noh
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Kang
authors.forename: Ji Min
authors.initials: JM
authors.lastname: Jung
authors.forename: Seong Eun
authors.initials: SE
authors.lastname: Kim
authors.forename: Hye Kyung
authors.initials: HK
authors.lastname: Jung
authors.forename: Ki Nam
authors.initials: KN
authors.lastname: Shim
authors.forename: Tae Hun
authors.initials: TH
authors.lastname: Kim
authors.forename: Kwon
authors.initials: K
authors.lastname: Yoo
authors.forename: Il Hwan
authors.initials: IH
authors.lastname: Moon
authors.forename: Young Sun
authors.initials: YS
authors.lastname: Hong
mesh_terms: D015502:Absorptiometry, Photon; D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000097:blood; D015992:Body Mass Index; D015519:Bone Density; D002118:Calcium / Q000097:blood; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000000981:diagnostic imaging; D003424:Crohn Disease / Q000175:diagnosis / Q000000981:diagnostic imaging; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010758:Phosphorus / Q000097:blood; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000596:Amino Acids; D005938:Glucocorticoids; D015675:Osteocalcin; D010758:Phosphorus; C036020:deoxypyridinoline; D002118:Calcium