More modifiers move on DNA damage.
In mammalian cells the accumulation of repair proteins to double-strand breaks is a phosphorylation- and ubiquitylation-regulated process. Some of the genes that encode the kinases and ubiquitin ligases in this pathway are cancer predisposition genes, most prominently the breast cancer predisposition gene BRCA1, which encodes a ubiquitin ligase. How BRCA1 ligase activity was regulated following DNA damage was poorly understood. In this review I summarize new data that show a third post-translational modification, by the small ubiquitin like modifier SUMO, is part of the same cascade, enabling and activating DNA damage-regulated processes, including the BRCA1 ligase activity.
Morris
Joanna R
JR
Department of Medical and Molecular Genetics, King's College London, Guy's Medical School Campus, London, United Kingdom. jo.morris@genetics.kcl.ac.uk
D000818:Animals; D019313:BRCA1 Protein / Q000378:metabolism*; D004249:DNA Damage; D006801:Humans; D011499:Protein Processing, Post-Translational; D025841:Small Ubiquitin-Related Modifier Proteins / Q000378:metabolism*; D054875:Ubiquitination
D019313:BRCA1 Protein; D025841:Small Ubiquitin-Related Modifier Proteins
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