Serum levels of oncostatin M (a gp 130 cytokine): an inflammatory biomarker in periodontal disease.
OBJECTIVE
Periodontitis is considered to be a risk factor for systemic diseases such as atherosclerosis, diabetes, etc., and cytokines play a key role. The present study was carried out to measure the level of serum oncostatin M (OSM) in patients with chronic periodontitis, and to evaluate the effect of non-surgical periodontal therapy on the serum OSM concentration.


METHODS
Sixty subjects were divided into three groups (each group n = 20) based on the gingival index (GI), probing pocket depth (PPD) and clinical attachment level (CAL): group I healthy; group II gingivitis; and group III chronic periodontitis. Group III patients were followed for 8 weeks after non-surgical periodontal therapy as the after-treatment group (group IV). Estimation of serum OSM was done using an enzyme-linked immunosorbent assay.


RESULTS
The mean OSM concentrations in serum were highest in the chronic periodontitis group (mean 68.05 pg ml(-1)) and decreased following treatment (39.65 pg ml(-1)) while OSM was undetectable in healthy subjects or in patients with gingivitis.


CONCLUSIONS
Increased serum OSM concentration in patients with chronic periodontitis and its positive correlation with PPD and CAL, suggest its role as an inflammatory biomarker in periodontal disease and it may exaggerate other systemic conditions such as atherosclerosis and rheumatoid arthritis.
Pradeep
A R
AR
Department of Periodontics, Government Dental College and Research Institute, Bangalore, Karnataka, India. periodontics_gdc@rediffmail.com <periodontics_gdc@rediffmail.com>
S
Thorat Manojkumar
TM
Garima
Garg
G
Raju
Arjun
A
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood; D050197:Atherosclerosis / Q000097:blood; D015415:Biomarkers / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005891:Gingivitis / Q000097:blood; D006801:Humans; D007249:Inflammation; D008297:Male; D053683:Oncostatin M / Q000097:blood*; D010510:Periodontal Diseases / Q000097:blood* / Q000175:diagnosis; D012307:Risk Factors
D015415:Biomarkers; D016207:Cytokines; D053683:Oncostatin M