The impact of ethylene glycol monomethyl ether on ovarian function may extend to the next generation in female mice: a preliminary study.
Ethylene glycol monomethyl ether (EGME) is known to alter the reproductive function of exposed animals and their offspring; however, its influence on cumulus-oocyte complexes (COCs) remains unclear. This study assessed the toxicity of EGME on oocytes and COCs by analyzing the number of oocytes in the F0 and F1 generations and evaluating apoptosis in oocytes and COCs after treating the F0 generation with EGME. There was a dose-dependent increase in the apoptosis ratios in the COCs from F1 mice, which were not directly exposed to EGME, with apoptosis ratios of 0.065, 0.102, 0.184, and 0.212 for the 0%, 0.05%, 0.1%, and 0.2% EGME dose groups, respectively. The increased apoptosis of cumulus cells may play a role in the toxicity of EGME toward ovarian function. EGME toxicity seems to affect female offspring in future generation(s), but further studies with a large number of animals are necessary to verify these conclusions.
Weng
Shao-Ping
SP
Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, 17 Syujhou Road, Taipei 10055, Taiwan.
Wu
Tsung-Chieh J
TC
Chen
Shee-Uan
SU
Wu
Jui
J
Lin
Ching-Chun
CC
Yang
Ya-Chien
YC
Chen
Pau-Chung
PC
D000818:Animals; D000891:Anti-Infective Agents, Local / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects; D054885:Cumulus Cells / Q000187:drug effects / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D005026:Ethylene Glycols / Q000633:toxicity*; D005260:Female; D018095:Germ-Line Mutation / Q000187:drug effects*; D051379:Mice; D009865:Oocytes / Q000187:drug effects / Q000473:pathology; D010053:Ovary / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D000891:Anti-Infective Agents, Local; D005026:Ethylene Glycols; C005398:phenoxyethanol