title: Use of povidone-iodine drop instead of sub-conjunctival injection of dexamethasone and gentamicin combination at the end of phacoemulsification cataract surgery.
abstract: To evaluate the use of 5% povidone-iodine drop with subconjunctival injection of dexamethasone and gentamicin combination at the completion of phacoemulsification cataract surgery. This prospective randomized study was conducted at the department of Ophthalmology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh during the period of July, 2005 to June 2006. Senile & pre-senile cataract patients undergoing phacoemulsification cataract surgery were included in the study. Thirty patients were randomly included in Group A, receiving sub-conjunctival injection of dexamethasone and gentamicin combination and 30 patients in Group- B, receiving 5% povidone-iodine drop at the end of phacoemulsification surgery. Protocol for pre-operative medications, phacoemulsification technique and post-operative medications were similar in both groups. All patients were followed for 6 months post-operatively. Outcome measures were i) patients experience of pain and discomfort post-operatively ii) grade of inflammation post-operatively and iii) visual outcome. Difference of data between two groups was analyzed by unpaired 't' test and chi-square test. In Group A, mean age were 56.86+/-10.25 (SD) years and in Group B, mean age was 57.70+/-10.25 (SD) years. In Group A, 18(60%) patients were male and 12(40%) were female. In Group B, 16(53.33%) were male and 14(46.67%) were female. Pain and discomfort perceived by patients were measured by VAS at the end of operation, on 1st POD and after 7 days post-operatively. Mean VAS score was 5.7 in Group A and 2.7 in Group B at the end of surgery, 2.5 in Group A and 2.2 in Group B on 1st POD and 0.7 in Group A and 0.6 in Group B on 7th POD. Post-operative inflammation was assessed by slit lamp considering conjunctival congestion, chemosis, corneal striation, corneal oedema, cells and flare in anterior chamber. No significant difference was observed between two groups. Mean visual acuity was 0.16+/-0.12 in Group A and 0.15+/-0.13 in Group B. Anti-inflammatory, anti-infective effects and visual outcome are similar in both groups. But sub-conjunctival injection resulted more pain and hence less acceptable to patients.
authors.affiliation: Department of Ophthalmology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka, Bangladesh.
authors.forename: M S
authors.initials: MS
authors.lastname: Ahmed
authors.forename: K N
authors.initials: KN
authors.lastname: Moly
authors.forename: M A
authors.initials: MA
authors.lastname: Aziz
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D016009:Chi-Square Distribution; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage*; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010149:Postoperative Pain / Q000517:prevention & control; D018918:Phacoemulsification; D011183:Postoperative Complications / Q000517:prevention & control*; D011206:Povidone-Iodine / Q000008:administration & dosage*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000891:Anti-Infective Agents, Local; D005839:Gentamicins; D005938:Glucocorticoids; D009883:Ophthalmic Solutions; D003907:Dexamethasone; D011206:Povidone-Iodine