Successful treatment of aortic root dilatation in a patient with relapsing polychondritis.
Cardiovascular involvement occurring in 20-30% patients is the second most common cause of mortality in patients with relapsing polychondritis. Aortic insufficiency occurs as a result of aortic root dilatation rather than primary valvular involvement. We are reporting a patient of relapsing polychondritis with aortic root dilatation, in whom institution of early and aggressive therapy successfully prevented the progression of aortic insufficiency.
Sharma
Aman
A
Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, 160012 Chandigarh, India. amansharma74@yahoo.com
Mittal
Tarun
T
Kumar
Susheel
S
Law
Arjun Datt
AD
Wanchu
Ajay
A
Mahajan
Rajiv
R
Bambery
Pradeep
P
Singh
Surjit
S
D001011:Aorta / Q000187:drug effects* / Q000473:pathology; D001018:Aortic Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D001022:Aortic Valve Insufficiency / Q000209:etiology / Q000473:pathology / Q000517:prevention & control; D001379:Azathioprine / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004108:Dilatation, Pathologic / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D057915:Drug Substitution; D004359:Drug Therapy, Combination; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D011081:Polychondritis, Relapsing / Q000150:complications / Q000188:drug therapy*; D011239:Prednisolone / Q000627:therapeutic use
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone; D009173:Mycophenolic Acid; D001379:Azathioprine; D008775:Methylprednisolone
Medicine (Baltimore). 1976 May;55(3):193-215
775252
Br J Rheumatol. 1998 Dec;37(12):1359-61
9973170
J Clin Pathol. 2001 Nov;54(11):890-2
11684729
Ann Rheum Dis. 1992 Mar;51(3):413-5
1575597
J Rheumatol. 2005 May;32(5):954-6
15868636
Rheumatology (Oxford). 2007 Nov;46(11):1738-9
17933796
Laryngoscope. 1979 Jun;89(6 Pt 1):929-46
449538
Rheumatology (Oxford). 2009 Oct;48(10):1328-9
19651886
Scand J Rheumatol. 2007 Nov-Dec;36(6):462-5
18092269