title: Genome-wide association study of bipolar I disorder in the Han Chinese population.
abstract: We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of which three were not found in previous GWA studies in the Caucasian populations. Among them, SNPs close to specificity protein 8 (SP8) and ST8 α-N-acetyl- neuraminide α-2,8-sialyltransferase (ST8SIA2) are associated with Bipolar I, with P-values of 4.87 × 10(-7) (rs2709736) and 6.05 × 10(-6) (rs8040009), respectively. We have also identified SNPs in potassium channel tetramerization domain containing 12 gene (KCTD12) (rs2073831, P=9.74 × 10(-6)) and in CACNB2 (Calcium channel, voltage-dependent, β-2 subunit) gene (rs11013860, P=5.15 × 10(-5)), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed suggestive association in this study (P=6.55 × 10(-5) and P=1.48 × 10(-5), respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder.
authors.affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
authors.forename: M T M
authors.initials: MT
authors.lastname: Lee
authors.forename: C H
authors.initials: CH
authors.lastname: Chen
authors.forename: C S
authors.initials: CS
authors.lastname: Lee
authors.forename: C C
authors.initials: CC
authors.lastname: Chen
authors.forename: M Y
authors.initials: MY
authors.lastname: Chong
authors.forename: W C
authors.initials: WC
authors.lastname: Ouyang
authors.forename: N Y
authors.initials: NY
authors.lastname: Chiu
authors.forename: L J
authors.initials: LJ
authors.lastname: Chuo
authors.forename: C Y
authors.initials: CY
authors.lastname: Chen
authors.forename: H K L
authors.initials: HK
authors.lastname: Tan
authors.forename: H Y
authors.initials: HY
authors.lastname: Lane
authors.forename: T J
authors.initials: TJ
authors.lastname: Chang
authors.forename: C H
authors.initials: CH
authors.lastname: Lin
authors.forename: S H
authors.initials: SH
authors.lastname: Jou
authors.forename: Y M
authors.initials: YM
authors.lastname: Hou
authors.forename: J
authors.initials: J
authors.lastname: Feng
authors.forename: T J
authors.initials: TJ
authors.lastname: Lai
authors.forename: C L
authors.initials: CL
authors.lastname: Tung
authors.forename: T J
authors.initials: TJ
authors.lastname: Chen
authors.forename: C J
authors.initials: CJ
authors.lastname: Chang
authors.forename: F W
authors.initials: FW
authors.lastname: Lung
authors.forename: C K
authors.initials: CK
authors.lastname: Chen
authors.forename: I S
authors.initials: IS
authors.lastname: Shiah
authors.forename: C Y
authors.initials: CY
authors.lastname: Liu
authors.forename: P R
authors.initials: PR
authors.lastname: Teng
authors.forename: K H
authors.initials: KH
authors.lastname: Chen
authors.forename: L J
authors.initials: LJ
authors.lastname: Shen
authors.forename: C S
authors.initials: CS
authors.lastname: Cheng
authors.forename: T P
authors.initials: TP
authors.lastname: Chang
authors.forename: C F
authors.initials: CF
authors.lastname: Li
authors.forename: C H
authors.initials: CH
authors.lastname: Chou
authors.forename: C Y
authors.initials: CY
authors.lastname: Chen
authors.forename: K H T
authors.initials: KH
authors.lastname: Wang
authors.forename: C S J
authors.initials: CS
authors.lastname: Fann
authors.forename: J Y
authors.initials: JY
authors.lastname: Wu
authors.forename: Y T
authors.initials: YT
authors.lastname: Chen
authors.forename: A T A
authors.initials: AT
authors.lastname: Cheng
mesh_terms: D017487:Ankyrins / Q000235:genetics; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D001714:Bipolar Disorder / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D020746:Calcium Channels, L-Type / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011506:Proteins / Q000235:genetics; D015203:Reproducibility of Results; D012799:Sialyltransferases / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
chemical_list: D017487:Ankyrins; D020746:Calcium Channels, L-Type; D004268:DNA-Binding Proteins; D011506:Proteins; D012799:Sialyltransferases; D014157:Transcription Factors; C490613:ANK3 protein, human; C107597:CACNB2 protein, human; C493175:KCTD12 protein, human; C501901:SP8 protein, human; C046778:CMP-N-acetylneuraminate-poly-alpha-2,8-sialosyl sialyltransferase