title: IL-17 in sera from patients with aggressive periodontitis.
abstract: Interleukin-17 (IL-17), the prototype cytokine produced by the Th17 subset of T-helper cells, plays a role in inflammatory responses, autoimmunity, and antimicrobial responses in a variety of infectious and inflammatory diseases. In view of the inflammatory nature and severity of aggressive periodontitis, we hypothesized that IL-17 might be detected in sera from patients with aggressive periodontitis. We used ELISA to measure IL-17 serum concentrations from 67 periodontally healthy (NP) individuals and from 53 patients with localized (LAgP) and 49 patients with generalized (GAgP) aggressive periodontitis. IL-17 was barely detectable in sera from periodontally healthy individuals (1.9 +/- 2.0 pg/mL), but was present at significantly higher concentrations in sera from those with LAgP (7.6 +/- 2.2 pg/mL) and GAgP (17.1 +/- 2.3 pg/mL). Multivariate analyses demonstrated associations of IL-17 concentrations with periodontal attachment loss, but not with current smoking. Therefore, Th17 responses may be characteristic of AgP, and IL-17 may play a role in the pathogenesis of aggressive periodontitis.
authors.affiliation: Department of Periodontics, School of Dentistry, Virginia Commonwealth University, Richmond, VA 23298-0566, USA. haschenk@vcu.edu
authors.forename: H A
authors.initials: HA
authors.lastname: Schenkein
authors.forename: T E
authors.initials: TE
authors.lastname: Koertge
authors.forename: C N
authors.initials: CN
authors.lastname: Brooks
authors.forename: R
authors.initials: R
authors.lastname: Sabatini
authors.forename: D E
authors.initials: DE
authors.lastname: Purkall
authors.forename: J G
authors.initials: JG
authors.lastname: Tew
mesh_terms: D010520:Aggressive Periodontitis / Q000097:blood* / Q000276:immunology*; D000704:Analysis of Variance; D044383:Black People; D016022:Case-Control Studies; D005260:Female; D005881:Gingiva / Q000276:immunology; D006801:Humans; D020381:Interleukin-17 / Q000097:blood*; D008297:Male; D017622:Periodontal Attachment Loss / Q000097:blood; D010512:Periodontal Index; D012044:Regression Analysis; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D055815:Young Adult
chemical_list: D020381:Interleukin-17
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