title: Day-5 inhibin B serum concentrations and antral follicle count as predictors of ovarian response and live birth in assisted reproduction cycles stimulated with gonadotropin after pituitary suppression.
abstract: OBJECTIVE
  To investigate the usefulness of day-5 inhibin B and antral follicle count (AFC) in predicting ovarian response and live birth in the first cycle of assisted reproduction.
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  Ninety-eight infertile women treated with in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) comprising 72 normal responders and 26 poor responders.
  
  
  METHODS
  Ovarian stimulation with gonadotropin-releasing hormone agonist-gonadotropin treatment.
  
  
  METHODS
  Basal ultrasonographic (AFC, total ovarian volume) and basal (follicle-stimulating hormone, estradiol, and inhibin B) and stimulation day-5 (estradiol, inhibin B) hormone parameters.
  
  
  RESULTS
  The AFC had the best predictive value among the basal variables for outcome of ovarian stimulation. Among the dynamic hormone measurements, day-5 inhibin serum measurement emerged as the best predictive variable of poor response in IVF-ICSI cycles, but it was not statistically significantly better than basal AFC. The association of day-5 inhibin B with live-birth rate was statistically significant and stronger than the effect of any other variable investigated.
  
  
  CONCLUSIONS
  Basal AFC and day-5 inhibin B have similar predictive properties for ovarian response in assisted reproduction cycles stimulated with gonadotropin after pituitary suppression, but day-5 inhibin B is a superior predictor of live birth.
authors.affiliation: Institut Clínic of Gynecology, Obstetrics, and Neonatology, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
authors.forename: Joana
authors.initials: J
authors.lastname: Peñarrubia
authors.forename: Sara
authors.initials: S
authors.lastname: Peralta
authors.forename: Francisco
authors.initials: F
authors.lastname: Fábregues
authors.forename: Francisco
authors.initials: F
authors.lastname: Carmona
authors.forename: Roser
authors.initials: R
authors.lastname: Casamitjana
authors.forename: Juan
authors.initials: J
authors.lastname: Balasch
mesh_terms: D000328:Adult; D002452:Cell Count; D015536:Down-Regulation / Q000187:drug effects; D005260:Female; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007246:Infertility / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy*; D007265:Inhibins / Q000032:analysis / Q000097:blood*; D050498:Live Birth / Q000453:epidemiology; D009994:Osmolar Concentration; D006080:Ovarian Follicle / Q000187:drug effects / Q000473:pathology*; D010062:Ovulation Induction / Q000379:methods; D010902:Pituitary Gland / Q000187:drug effects / Q000502:physiology; D011247:Pregnancy; D011379:Prognosis; D027724:Reproductive Techniques, Assisted; D013997:Time Factors
chemical_list: D006062:Gonadotropins; C422364:inhibin B; D007265:Inhibins