L-methylfolate, methylcobalamin, and N-acetylcysteine in the treatment of Alzheimer's disease-related cognitive decline.
Neuroinflammatory oxidative stress occurs early in AD pathology. Elevated blood Hcy is a useful marker for such neuroinflammation. Hcy contributes to pathological cascades involving AP and NFTs. In AD, Hcy should be lowered by B-vitamin supplements and NAC.
McCaddon
Andrew
A
Cardiff University, Cardiff School of Medicine, North Wales, United Kingdom.
Hudson
Peter R
PR
D000111:Acetylcysteine / Q000627:therapeutic use*; D000544:Alzheimer Disease / Q000097:blood / Q000134:cerebrospinal fluid / Q000150:complications* / Q000473:pathology; D003072:Cognition Disorders / Q000097:blood / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000209:etiology*; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D006710:Homocysteine / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D018384:Oxidative Stress; D058225:Plaque, Amyloid / Q000473:pathology; D013763:Tetrahydrofolates / Q000627:therapeutic use*; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000627:therapeutic use; D014803:Vitamin B Complex / Q000627:therapeutic use
D016166:Free Radical Scavengers; D013763:Tetrahydrofolates; D006710:Homocysteine; D014803:Vitamin B Complex; C019476:mecobalamin; D014805:Vitamin B 12; C005984:5-methyltetrahydrofolate; D000111:Acetylcysteine