Prognostic role of pigment epithelium-derived factor in clear cell renal cell carcinoma.
OBJECTIVE
The purpose of this study was to investigate the prognostic significance of pigment epithelium-derived factor (PEDF) in human clear cell renal cell carcinoma (CCRCC) tissues.


METHODS
We investigated the expression of PEDF and its correlation with clinicopathological features in 203 patients who underwent radical nephrectomy for CCRCC. Expression of PEDF and CD34-positive vessels (microvessel density, MVD) in tumor samples was examined by immunohistochemistry. The relationship between PEDF expression and clinicopathologic features including tumor diameter, MVD, and survival was evaluated by univariate and multivariate analyses.


RESULTS
Of 203 patients, 116 cases (57.1%) were positive for PEDF. A significant association was found between PEDF expression and high MVD (p = 0.012). PEDF expression was inversely correlated with grade (p = 0.004) and pT stage (p = 0.001). Multivariate analysis using the Cox regression model indicated that PEDF expression was an independent favorable prognostic factor (risk ratio, 4.105; p = 0.001). However, no significant correlation was found between PEDF expression and age, gender, tumor diameter or lymph node invasion.


CONCLUSIONS
Our findings suggest that PEDF may be a favorable prognostic indicator in patients with CCRCC.
Jiang
Zhaohui
Z
Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.
Fang
Zhujun
Z
Ding
Qiang
Q
D002292:Carcinoma, Renal Cell / Q000737:chemistry / Q000378:metabolism* / Q000401:mortality; D005136:Eye Proteins / Q000032:analysis / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009414:Nerve Growth Factors / Q000032:analysis / Q000096:biosynthesis*; D011379:Prognosis; D012189:Retrospective Studies; D015843:Serpins / Q000032:analysis / Q000096:biosynthesis*; D015996:Survival Rate; D000099174:Pigment Epithelium-Derived Factor
D005136:Eye Proteins; D009414:Nerve Growth Factors; D015843:Serpins; D000099174:Pigment Epithelium-Derived Factor