Delta-sarcoglycan gene polymorphism frequency in Amerindian and Mestizo populations of Mexico.
Mutations on the delta-sarcoglycan gene have been associated with the development of both hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy. Recently, the polymorphism c.-94C>G was associated with HCM in Japanese patients. The aim of our study was to evaluate the frequency of c.-94C>G polymorphism in Mexican-Amerindian and Mexican-Mestizo populations. We analyzed the frequency of this polymorphism in 165 Mexican-Amerindian individuals (23 Triquis, 25 Zapotecos, 24 Mayas, 41 Nahuas, and 52 Mixtecos) and 100 unrelated Mexican-Mestizos. Allele frequencies were similar in all Amerindian groups (0.33 Triquis, 0.54 Zapotecos, 0.54 Mayas, 0.46 Nahuas, and 0.49 Mixtecos). When compared with Mexican-Mestizos, only Triquis were different (p = 0.00742). However, when comparing the total sample of the Amerindian population with the Mestizos, the difference was not significant (p = 0.12225). Allele frequencies of Mexican populations were higher than in Asians and less than African and European populations (p < 0.05). These data show that the distribution of the C allele is higher in Mexican populations studied and consequently it is necessary to define if this may be associated with genetic susceptibility for HCM in the Mexican patients.
Ordoñez-Razo
Rosa María
RM
Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico. romaorr@yahoo.com.mx
Canizales-Quinteros
Samuel
S
Rodríguez-Cruz
Maricela
M
Peñaloza
Rosenda
R
Minauro-Sanmiguel
Fernando
F
Canto-Cetina
Thelma
T
Canto
Patricia
P
Coral-Vázquez
Ramón
R
Salamanca-Gómez
Fabio
F
D000328:Adult; D000368:Aged; D000483:Alleles; D002311:Cardiomyopathy, Dilated / Q000235:genetics; D024741:Cardiomyopathy, Hypertrophic, Familial / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D008800:Mexico; D008875:Middle Aged; D009154:Mutation; D020641:Polymorphism, Single Nucleotide; D049031:Sarcoglycans / Q000235:genetics*
D049031:Sarcoglycans