Formation of spray-dried powder of S-adenosyl-L-methionine.
S-Adenosyl-L-methionine (SAM) is an essential metabolite in all living organisms. In clinical research, SAM has also been suggested as a chemotherapeutic agent in various diseases. The main problem of SAM is its instability at high temperatures, at neutral and alkaline pH, and in the presence of humidity. SAM retention in spray-dried powder was determined under various conditions of spray-drying. The highest SAM retention was obtained when maltodextrin (dextrose equivalent, DE, of 25) was used as the carrier solid with the SAM feed liquid at pH 4.0. The water content in the powder had a significant effect on the stability of SAM. SAM powder with lower water content exhibited higher stability.
Lauruengtana
Vichuta
V
Department of Biotechnology, Graduate school of Engineering, Tottori University, Tottori, Japan.
Yanagita
Arisa
A
Neoh
Tze Loon
TL
Furuta
Takeshi
T
Kanai
Muneyoshi
M
Iefuji
Haruyuki
H
Yoshii
Hidefumi
H
D003890:Desiccation; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D011134:Polysaccharides / Q000737:chemistry; D011208:Powders / Q000737:chemistry*; D012436:S-Adenosylmethionine / Q000737:chemistry*; D013696:Temperature; D014867:Water / Q000737:chemistry
D011134:Polysaccharides; D011208:Powders; D014867:Water; C008315:maltodextrin; D012436:S-Adenosylmethionine