Pseudolaric acids: isolation, bioactivity and synthetic studies.
The pseudolaric acids are diterpenoids isolated from the root bark of Pseudolarix amabilis, or the golden larch. Pseudolaric acids A and B are the major antifungal and anti-angiogenic congeners of this family of compounds. This review presents the results of the isolation, biological and synthetic studies of these natural products. 127 references are cited.
Chiu
Pauline
P
Department of Chemistry and the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China. pchiu@hku.hk
Leung
Lai To
LT
Ko
Ben C B
BC
D020533:Angiogenesis Inhibitors; D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003270:Contraceptive Agents; D004224:Diterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D020533:Angiogenesis Inhibitors; D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D001688:Biological Products; D003270:Contraceptive Agents; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C058391:pseudolaric acid B; C058390:pseudolaric acid A