title: N-terminal type III secretion signal of enteropathogenic Escherichia coli translocator proteins.
abstract: We report that the N terminus of the type III secretion system translocator proteins EspB, EspD, and EspA mediate protein secretion and translocation from wild-type enteropathogenic Escherichia coli and hypersecretion from sepL and sepD mutants. EspA containing the translocation signal of Map and Tir containing the secretion signal of EspA are biologically active.
authors.affiliation: Flowers Building, Imperial College, London SW7 2AZ, United Kingdom. g.frankel@imperial.ac.uk.
authors.forename: Diana
authors.initials: D
authors.lastname: Munera
authors.forename: Valerie F
authors.initials: VF
authors.lastname: Crepin
authors.forename: Olivier
authors.initials: O
authors.lastname: Marches
authors.forename: Gad
authors.initials: G
authors.lastname: Frankel
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism; D054308:Enteropathogenic Escherichia coli / Q000235:genetics / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000235:genetics / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism
chemical_list: D001425:Bacterial Outer Membrane Proteins; C087863:EaeB protein, E coli; D029968:Escherichia coli Proteins; C102051:EspA protein, E coli; C474481:EspD protein, E coli; C512346:Map protein, E coli; D011956:Receptors, Cell Surface; C495684:SepD protein, E coli; C416081:SepL protein, E coli; C109287:Tir protein, E coli
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