Experimental study of hypotensive effect of kardos in rats with inherited hypertension.
Kardos, a preparation containing ultralow doses of antibodies to C-terminal fragment of type 1 receptor of angiotensin II, intragastrically administered to SHR rats with hereditary hypertension for 28 days reduced blood pressure by 14.8%. Kardos was not inferior to losartan and, in contrast to the latter reduced HR by 9.4%.
Medvedeva
N A
NA
Biological Faculty, M V Lomonosov Moscow State University.
Artem'eva
M M
MM
Kheyfets
I A
IA
Dugina
Yu L
YL
Sabanov
L B
LB
Zabolotneva
Yu A
YA
Kachanova
M V
MV
Sergeeva
S A
SA
Epshtein
O I
OI
D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000276:immunology / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D019808:Losartan / Q000627:therapeutic use; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011945:Receptors, Angiotensin / Q000276:immunology
D000906:Antibodies; D000959:Antihypertensive Agents; D011945:Receptors, Angiotensin; D019808:Losartan