Polycationic nanoparticles as nonviral vectors employed for gene therapy in vivo.
Currently, polycationic nanoparticles (polycation) as nonviral vectors are promising to overcome the defects of traditional viral vectors. This review focuses on the recent progress and challenges to improve the transfection efficacy and circulation time of polyplexes (complexes between polycation and pDNA or oligonucleotides such as siRNA) in vivo.
Xing
Jinfeng
J
Department of Polymer Science and Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, PR China. liangxj@nanoctr.cn
Deng
Liandong
L
Guo
Shutao
S
Dong
Anjie
A
Liang
Xing-Jie
XJ
D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D053758:Nanoparticles / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry / Q000494:pharmacology; D010957:Plasmids / Q000737:chemistry / Q000494:pharmacology; D011073:Polyamines / Q000737:chemistry* / Q000494:pharmacology; D000071228:Polyelectrolytes
D009841:Oligonucleotides; D011073:Polyamines; D000071228:Polyelectrolytes