Drug repurposing for drug development in stroke.
The development of new treatments for acute stroke has been fraught with costly and spectacularly disappointing failures. Repurposing of safe, older drugs provides a lower risk alternative. Vascular protection with candesartan is one such approach.
Fagan
Susan C
SC
Program in Clinical and Experimental Therapeutics, University of Georgia College of Pharmacy, Augusta, GA, USA.
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001562:Benzimidazoles / Q000627:therapeutic use; D001713:Biphenyl Compounds; D055808:Drug Discovery / Q000379:methods* / Q000639:trends; D006801:Humans; D020521:Stroke / Q000188:drug therapy*; D013777:Tetrazoles / Q000627:therapeutic use
D000959:Antihypertensive Agents; D001562:Benzimidazoles; D001713:Biphenyl Compounds; D013777:Tetrazoles; C081643:candesartan