title: [Perioperative beta-receptor blockade. For and against].
abstract: Results from recent studies have questioned the application of beta-receptor blockers for reduction of morbidity and mortality during the perioperative period. This holds true especially for patients with no or only low cardiac risk. Although beta-receptor blockade was a form of standard therapy at the end of the 1990s, data today show no clear evidence for such a therapy not even in patients at risk for cardiac events. At least in patients with low risk the initiation of beta-receptor blockade during the perioperative period might lead to side-effects, thereby increasing morbidity and mortality.
authors.affiliation: Department of Anesthesiology, Academic Medical Centre AMC, University of Amsterdam, Meibergdreef 9, 1100 Amsterdam, The Netherlands. b.preckel@amc.uva.nl
authors.forename: B
authors.initials: B
authors.lastname: Preckel
authors.forename: M
authors.initials: M
authors.lastname: Poels
authors.forename: F
authors.initials: F
authors.lastname: Wappler
authors.forename: W
authors.initials: W
authors.lastname: Schlack
authors.forename: W
authors.initials: W
authors.lastname: Buhre
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D006331:Heart Diseases / Q000150:complications; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D009203:Myocardial Infarction / Q000517:prevention & control; D019990:Perioperative Care / Q000401:mortality; D011183:Postoperative Complications / Q000139:chemically induced / Q000401:mortality; D016032:Randomized Controlled Trials as Topic; D012306:Risk; D018570:Risk Assessment
chemical_list: D000319:Adrenergic beta-Antagonists
references.citation: BMJ. 2005 Aug 6;331(7512):313-21
references.pmid: 15996966
references.citation: Anesth Analg. 2008 Apr;106(4):1039-48, table of contents
references.pmid: 18349171
references.citation: J Vasc Surg. 2005 Apr;41(4):602-9
references.pmid: 15874923
references.citation: J Am Coll Cardiol. 2006 Sep 5;48(5):964-9
references.pmid: 16949487
references.citation: Anesth Analg. 2000 Jun;90(6):1257-61
references.pmid: 10825304
references.citation: N Engl J Med. 1999 Dec 9;341(24):1789-94
references.pmid: 10588963
references.citation: Circulation. 2006 Feb 21;113(7):e166-286
references.pmid: 16490830
references.citation: Am Heart J. 2001 Jan;141(1):148-53
references.pmid: 11136500
references.citation: Lancet. 1999 Jan 2;353(9146):9-13
references.pmid: 10023943
references.citation: Can J Anaesth. 1991 Oct;38(7):849-58
references.pmid: 1683818
references.citation: Anesth Analg. 2007 Jan;104(1):27-41
references.pmid: 17179240
references.citation: Ann Surg. 2009 Jun;249(6):921-6
references.pmid: 19474688
references.citation: Am Heart J. 2007 Feb;153(2):224-30
references.pmid: 17239680
references.citation: Eur J Clin Pharmacol. 1988;33 Suppl:S19-24
references.pmid: 3371390
references.citation: Lancet. 2003 Jul 5;362(9377):7-13
references.pmid: 12853193
references.citation: Br J Anaesth. 2008 Aug;101(2):135-8
references.pmid: 18614596
references.citation: Am J Med. 2005 Oct;118(10):1134-41
references.pmid: 16194645
references.citation: Circulation. 2009 Nov 24;120(21):2123-51
references.pmid: 19884474
references.citation: Cardiovasc Res. 1997 Feb;33(2):243-57
references.pmid: 9074687
references.citation: Best Pract Res Clin Anaesthesiol. 2005 Mar;19(1):77-95
references.pmid: 15679060
references.citation: J Cardiothorac Vasc Anesth. 2003 Feb;17(1):90-100
references.pmid: 12635070
references.citation: Circulation. 2006 Jul 4;114(1 Suppl):I344-9
references.pmid: 16820598
references.citation: Anesthesiology. 2005 May;102(5):885-91
references.pmid: 15851872
references.citation: Br J Anaesth. 2008 Jan;100(1):23-8
references.pmid: 18029345
references.citation: Cardiovasc Pathol. 1999 May-Jun;8(3):133-9
references.pmid: 10722235
references.citation: Prog Cardiovasc Dis. 1999 Jan-Feb;41(4):301-21
references.pmid: 10362350
references.citation: Am Heart J. 2006 Aug;152(2):223-30
references.pmid: 16875901
references.citation: Lancet. 2005 Jul 30-Aug 5;366(9483):359-60
references.pmid: 16060049
references.citation: Am Heart J. 2004 Dec;148(6):1047-52
references.pmid: 15632892
references.citation: Lancet. 2008 Dec 6;372(9654):1962-76
references.pmid: 19012955
references.citation: J Thorac Cardiovasc Surg. 1972 Nov;64(5):826-30
references.pmid: 5083583
references.citation: Circulation. 2009 Nov 24;120(21):e169-276
references.pmid: 19884473
references.citation: Circulation. 1999 Sep 7;100(10):1043-9
references.pmid: 10477528
references.citation: Anesthesiology. 2007 Jul;107(1):33-44
references.pmid: 17585213
references.citation: N Engl J Med. 2005 Jul 28;353(4):349-61
references.pmid: 16049209
references.citation: N Engl J Med. 1998 Aug 20;339(8):489-97
references.pmid: 9709041
references.citation: Circulation. 2002 Mar 12;105(10):1257-67
references.pmid: 11889023
references.citation: Br J Anaesth. 1973 Jul;45(7):671-81
references.pmid: 4147153
references.citation: Eur J Vasc Endovasc Surg. 2007 Jan;33(1):13-9
references.pmid: 16935011
references.citation: Eur Heart J. 2009 Nov;30(22):2769-812
references.pmid: 19713421
references.citation: Eur Heart J. 2001 Aug;22(15):1353-8
references.pmid: 11465968
references.citation: N Engl J Med. 1996 Dec 5;335(23):1713-20
references.pmid: 8929262
references.citation: J Cardiothorac Vasc Anesth. 2005 Apr;19(2):237-41
references.pmid: 15868537
references.citation: Am Heart J. 2006 Nov;152(5):983-90
references.pmid: 17070177
references.citation: J Hypertens. 2007 Apr;25(4):731-41
references.pmid: 17351362
references.citation: Anesthesiology. 1999 Dec;91(6):1674-86
references.pmid: 10598610
references.citation: Anesth Analg. 1999 Mar;88(3):477-82
references.pmid: 10071990
references.citation: Lancet. 2005 Nov 5;366(9497):1622-32
references.pmid: 16271643
references.citation: Int J Cardiol. 1996 Nov 15;57(1):37-44
references.pmid: 8960941
references.citation: Circulation. 2006 Jun 6;113(22):2662-74
references.pmid: 16754815
references.citation: Lancet. 2000 Jul 29;356(9227):359-65
references.pmid: 10972367
references.citation: Circulation. 2007 Oct 23;116(17):e418-99
references.pmid: 17901357
references.citation: BMJ. 2006 Jun 24;332(7556):1482
references.pmid: 16793810
references.citation: Br J Anaesth. 1988 Dec;61(6):675-9
references.pmid: 3207540
references.citation: Lancet. 2008 May 31;371(9627):1839-47
references.pmid: 18479744