title: Effect of impaza on cardiovascular system.
abstract: Experiment on ISIAH rats showed that antibodies to endothelial NO synthase in ultralow doses (impaza) produced a mild and progressive antihypertensive effect slightly inferior to that of losartan. The use of impaza is perspective in patients with erectile dysfunction and cardiovascular pathology.
authors.affiliation: Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk.
authors.forename: A L
authors.initials: AL
authors.lastname: Markel'
authors.forename: E S
authors.initials: ES
authors.lastname: Zhavbert
authors.forename: S A
authors.initials: SA
authors.lastname: Tarasov
authors.forename: Yu L
authors.initials: YL
authors.lastname: Dugina
authors.forename: M V
authors.initials: MV
authors.lastname: Kachanova
authors.forename: S A
authors.initials: SA
authors.lastname: Sergeeva
authors.forename: O I
authors.initials: OI
authors.lastname: Epshtein
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000276:immunology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D002319:Cardiovascular System / Q000187:drug effects*; D007172:Erectile Dysfunction / Q000188:drug therapy; D006973:Hypertension / Q000188:drug therapy; D019808:Losartan / Q000627:therapeutic use; D008297:Male; D019001:Nitric Oxide Synthase / Q000276:immunology; D011897:Random Allocation; D051381:Rats; D016896:Treatment Outcome
chemical_list: D000906:Antibodies; D000959:Antihypertensive Agents; C534505:IMPAZA; D019001:Nitric Oxide Synthase; D019808:Losartan