title: Drug-induced gynecomastia in children and adolescents.
abstract: OBJECTIVE
  I frequently see adolescent boys in my practice with transient gynecomastia. My management includes reassuring the boys and their families; however, I also understand that specific medication, alcohol, and drugs can cause gynecomastia. How common is this phenomenon, and what medications can induce gynecomastia?
  
  
  CONCLUSIONS
  While gynecomastia is a physiologic phenomenon in most newborns and adolescents, it is important to consider pathologic conditions and medications that can cause breast enlargement. Antibiotics, antiulcer drugs, growth hormones, and chemotherapy have been reported to induce gynecomastia. Adolescents who use anabolic steroids, or who abuse alcohol, marijuana, heroin, or amphetamines, should be alerted to the fact that gynecomastia might develop. Treatment of drug-induced gynecomastia includes discontinuation of the offending drug. Very rarely is surgical intervention required.
authors.affiliation: BC Children's Hospital, Department of Pediatrics, Room K4-226, Ambulatory Care Bldg, 4480 Oak St, Vancouver, BC V6H 3V4. rgoldman@cw.bc.ca
authors.forename: Ran D
authors.initials: RD
authors.lastname: Goldman
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D064420:Drug-Related Side Effects and Adverse Reactions; D006177:Gynecomastia / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D007231:Infant, Newborn; D008297:Male
references.citation: Cleve Clin J Med. 2004 Jun;71(6):511-7
references.pmid: 15242307
references.citation: J Clin Endocrinol Metab. 1984 Mar;58(3):492-9
references.pmid: 6693546
references.citation: N Engl J Med. 1978 Jul 6;299(1):12-6
references.pmid: 661845
references.citation: N Engl J Med. 2007 Feb 1;356(5):479-85
references.pmid: 17267908
references.citation: Clin Pediatr (Phila). 2007 Jul;46(6):487-90
references.pmid: 17579100
references.citation: Expert Opin Drug Saf. 2008 Nov;7(6):691-702
references.pmid: 18983216
references.citation: Pharmacotherapy. 1993 Jan-Feb;13(1):37-45
references.pmid: 8094898
references.citation: Arch Dis Child. 1981 Jul;56(7):525-9
references.pmid: 7271286
references.citation: J Clin Gastroenterol. 1997 Mar;24(2):79-81
references.pmid: 9077721
references.citation: JAMA. 1980 Jul 11;244(2):160-4
references.pmid: 6991731
references.citation: N Engl J Med. 1993 Feb 18;328(7):490-5
references.pmid: 8421478