ADAR editing in double-stranded UTRs and other noncoding RNA sequences.
ADARs are a family of enzymes, present in all animals, that convert adenosine to inosine within double-stranded RNA (dsRNA). Inosine and adenosine have different base-pairing properties, and thus, editing alters RNA structure, coding potential and splicing patterns. The first ADAR substrates identified were edited in codons, and ADARs were presumed to function primarily in proteome diversification. Although this is an important function of ADARs, especially in the nervous system, editing in coding sequences is rare compared to editing in noncoding sequences. Introns and untranslated regions of mRNA are the primary noncoding targets, but editing also occurs in small RNAs, such as miRNAs. Although the role of editing in noncoding sequences remains unclear, ongoing research suggests functions in the regulation of a variety of post-transcriptional processes.
Hundley
Heather A
HA
Department of Biochemistry, University of Utah, Salt Lake City, UT 84112, USA. hahundle@iupui.edu
Bass
Brenda L
BL
D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D001483:Base Sequence; D006801:Humans; D017393:RNA Editing; D012330:RNA, Double-Stranded / Q000235:genetics*; D022661:RNA, Untranslated / Q000235:genetics*
D012330:RNA, Double-Stranded; D022661:RNA, Untranslated; D000243:Adenosine Deaminase
Cell Cycle. 2008 Nov 1;7(21):3294-301
18948735
Nat Struct Mol Biol. 2005 Jun;12(6):489-96
15895094
Science. 2007 Feb 23;315(5815):1137-40
17322061
J Cell Biol. 2006 Mar 13;172(6):803-8
16520386
EMBO J. 2002 Nov 15;21(22):6025-35
12426375
Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12897-902
18723671
Proc Natl Acad Sci U S A. 1989 Apr;86(8):2647-51
2704740
Cell. 2009 Feb 20;136(4):642-55
19239886
Mol Cell. 2009 Mar 27;33(6):717-26
19217333
Science. 1994 Dec 9;266(5191):1709-13
7992055
Nat Struct Mol Biol. 2006 Jan;13(1):13-21
16369484
Biochemistry. 2000 Oct 24;39(42):12875-84
11041852
EMBO Rep. 2007 Aug;8(8):763-9
17599088
Cell. 1991 Oct 4;67(1):11-9
1717158
Cell. 2000 Apr 28;101(3):235-8
10847677
EMBO J. 2002 Sep 16;21(18):4950-8
12234934
Mol Cell. 2008 Aug 8;31(3):309-12
18691963
J Biol Chem. 2004 Feb 6;279(6):4941-51
14660658
EMBO J. 2009 Oct 21;28(20):3145-56
19713932
RNA. 2004 Aug;10(8):1174-7
15272117
Nature. 2003 Sep 25;425(6956):411-4
14508492
Annu Rev Biochem. 2002;71:817-46
12045112
J Cell Biol. 2009 Sep 7;186(5):637-44
19720872
Mol Cell. 2007 Nov 9;28(3):491-500
17996712
Genome Res. 2009 Mar;19(3):347-59
19106332
Mol Endocrinol. 2003 Sep;17(9):1805-14
12819296
Nat Immunol. 2009 Jan;10(1):109-15
19060901
EMBO J. 1991 Nov;10(11):3523-32
1915306
Nat Biotechnol. 2004 Aug;22(8):1001-5
15258596
Science. 2000 Dec 1;290(5497):1765-8
11099415
J Mol Biol. 2009 Nov 6;393(4):777-87
19733181
PLoS Biol. 2004 Dec;2(12):e391
15534692
Curr Opin Cell Biol. 2005 Jun;17(3):302-8
15901501
Genome Biol. 2006;7(4):R27
16594986
Genome Res. 2004 Sep;14(9):1719-25
15342557
Mol Cell. 2002 Oct;10(4):809-17
12419225
Cell. 2001 Aug 24;106(4):465-75
11525732
Nucleic Acids Res. 2008 Sep;36(16):5270-80
18684997
Cell. 2000 Aug 18;102(4):437-49
10966106
Biochemistry. 1997 Jul 15;36(28):8429-34
9264612
Cell. 1993 Dec 31;75(7):1361-70
8269514
Genome Res. 2004 Dec;14(12):2379-87
15545495
Nature. 2000 Jul 6;406(6791):78-81
10894545
EMBO Rep. 2001 Dec;2(12):1107-11
11743024
Cold Spring Harb Symp Quant Biol. 2006;71:285-92
17381308
EMBO J. 1994 Dec 1;13(23):5701-11
7527340
Genetics. 2000 Jul;155(3):1149-60
10880477
Chem Rev. 2006 Aug;106(8):3397-411
16895334
Cell. 1988 Dec 23;55(6):1089-98
3203381
Cancer Res. 2005 Dec 1;65(23):10742-9
16322219
EMBO J. 2008 Jun 18;27(12):1694-705
18497743
FEBS J. 2005 May;272(9):2109-17
15853796
EMBO J. 2001 Aug 1;20(15):4243-52
11483527
Proc Natl Acad Sci U S A. 1999 May 25;96(11):6048-53
10339539
Curr Top Microbiol Immunol. 2007;316:253-92
17969452
Science. 2003 Dec 5;302(5651):1725
14657490
Nature. 1997 May 15;387(6630):303-8
9153397
RNA. 2007 Jul;13(7):1103-15
17507659
Mol Cell Biol. 1995 Sep;15(9):4735-44
7651391
Wiley Interdiscip Rev Syst Biol Med. 2009 Sep-Oct;1(2):202-209
20835992
Nat Rev Mol Cell Biol. 2006 Dec;7(12):919-31
17139332
RNA. 2008 Oct;14(10):2050-60
18719245
J Mol Biol. 1999 Aug 6;291(1):1-13
10438602
Mol Cell. 2009 Aug 28;35(4):467-78
19716791
Annu Rev Genet. 2000;34:499-531
11092837
Cell. 2005 Oct 21;123(2):249-63
16239143
Prog Nucleic Acid Res Mol Biol. 2005;79:299-338
16096031
RNA. 2003 Jul;9(7):839-46
12810917
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2525-30
19188602
Nucleic Acids Res. 2007;35(13):4485-94
17576664
J Biol Chem. 2005 Feb 4;280(5):3946-53
15556947