title: Porcine reproductive and respiratory syndrome virus entry into the porcine macrophage.
abstract: Porcine reproductive and respiratory syndrome virus (PRRSV) emerged in the late 1980s and rapidly became one of the most significant viral pathogens in the swine industry. In vivo, the virus shows a very narrow cell tropism and targets specific subsets of porcine macrophages. The entry of PRRSV into its host cell is the first crucial step in infection and has been the focus of many fundamental studies. This review provides a comprehensive overview of the current knowledge on PRRSV entry into the porcine macrophage, covering virus binding, internalization and genome release, and integrates these findings into a general model of the entry process.
authors.affiliation: Department of Virology, Parasitology and Immunology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
authors.forename: Wander
authors.initials: W
authors.lastname: Van Breedam
authors.forename: Peter L
authors.initials: PL
authors.lastname: Delputte
authors.forename: Hanne
authors.initials: H
authors.lastname: Van Gorp
authors.forename: Gerald
authors.initials: G
authors.lastname: Misinzo
authors.forename: Nathalie
authors.initials: N
authors.lastname: Vanderheijden
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Duan
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Nauwynck
mesh_terms: D000818:Animals; D008264:Macrophages / Q000502:physiology / Q000821:virology*; D019316:Porcine respiratory and reproductive syndrome virus / Q000502:physiology*; D013552:Swine; D056189:Viral Tropism / Q000502:physiology; D053586:Virus Internalization; D014779:Virus Replication / Q000502:physiology