Challenges of treating asthma in people who smoke.
Cigarette smoking is common in asthma and is associated with poor symptom control and a reduced therapeutic response to inhaled and oral corticosteroids as compared with nonsmokers with asthma. This review examines the range of adverse health effects of smoking in asthma, the inflammatory mechanisms that may influence the efficacy of current drugs and discusses potential future therapeutic directions.
Spears
Mark
M
Respiratory Medicine Section, Division of Immunology, Infection and Inflammation, Gartnavel General Hospital & University of Glasgow, Glasgow G12 OYN, UK. ms249j@clinmed.gla.ac.uk
Cameron
Euan
E
Chaudhuri
Rekha
R
Thomson
Neil C
NC
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology / Q000503:physiopathology; D002986:Clinical Trials as Topic; D018450:Disease Progression; D004351:Drug Resistance; D006801:Humans; D007249:Inflammation; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D016540:Smoking Cessation; D000074606:Smoking Prevention
D000305:Adrenal Cortex Hormones