title: Antidiarrheal activity of aqueous extract of Hermannia incana Cav. leaves in Wistar rats.
abstract: Hermannia incana Cav. is a prostrate herb used to treat diarrhea, stomach ache, nausea and vomiting, by the people of Eastern Cape Province, South Africa. The phytochemical screening as well as the antidiarrheal activity of H. incana leaf extract at 200, 400 and 600 mg/kg body weight was evaluated in rats. Phytochemical screening revealed the presence of bioactive agents such as alkaloids, tannins, saponins, phenolics, triterpenes, cardiac glycosides, flavonoids, cardenolides and dienolides. The extract significantly prolonged the time of induction of diarrhea, reduced the frequency of diarrheal episodes and water content of the feces, and inhibited castor oil-induced enteropooling. The extract also suppressed intestinal propulsive movement of a charcoal meal through the gastrointestinal tract. These results demonstrate the antidiarrheal properties of the extract, thereby supporting the folkloric use of the plant as an antidiarrheal agent in the Eastern Cape of South Africa.
authors.affiliation: Department of Botany, University of Fort Hare, Alice, South Africa.
authors.forename: J R
authors.initials: JR
authors.lastname: Appidi
authors.forename: M T
authors.initials: MT
authors.lastname: Yakubu
authors.forename: D S
authors.initials: DS
authors.lastname: Grierson
authors.forename: A J
authors.initials: AJ
authors.lastname: Afolayan
mesh_terms: D000818:Animals; D000930:Antidiarrheals / Q000302:isolation & purification / Q000494:pharmacology*; D002368:Castor Oil / Q000494:pharmacology; D003967:Diarrhea / Q000188:drug therapy*; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects; D007419:Intestinal Secretions / Q000187:drug effects; D008139:Loperamide / Q000494:pharmacology; D008297:Male; D019660:Malvaceae / Q000737:chemistry*; D016488:Medicine, African Traditional; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D013019:South Africa; D013997:Time Factors
chemical_list: D000930:Antidiarrheals; D010936:Plant Extracts; D008139:Loperamide; D002368:Castor Oil