title: Treatment and outcome in muscle invasive bladder cancer: a population-based survey.
abstract: OBJECTIVE
  To assess treatments and survival of patients with muscle invasive bladder cancer (MIBC) in the Comprehensive Cancer Center Northern Netherlands (CCCN) region.
  
  
  METHODS
  Retrospective cohort analysis. Data of 548 patients with MIBC diagnosed between 1997 and 2002 were collected from the CCCN cancer registry. All had a follow-up of at least 5 years. Logistic regression analysis on treatments as well as survival analysis was performed.
  
  
  RESULTS
  The treatments were radical cystectomy in 205/548 (37.5%) patients. TUR plus radiotherapy in 246 (44.9%) and palliation in 97 (17.7%). Multivariate analysis identified TNM stage (P < 0.0001) and age (P < 0.0001) as independent variables for cystectomy. Hospital type and year of diagnosis were not significant different between patients treated by cystectomy versus other type of treatment. TNM stage (P < 0.0001), age (P = 0.0043), and comorbidity (P = 0.0028) were independent variables for disease-specific survival (DSS) after cystectomy.
  
  
  CONCLUSIONS
  In the CCCN region, only 1/3 of patients with MIBC were treated with radical cystectomy. TNM stage and age were identified as main variables for the choice for cystectomy. TNM stage, age, and comorbidity were independent variables for disease-specific survival after cystectomy.
authors.affiliation: Department of Urology, University Medical Center Groningen, Hanzeplein 1, P.O. box 30.001, 9700 RB, Groningen, The Netherlands. a.m.leliveld@uro.umcg.nl
authors.forename: Anna M
authors.initials: AM
authors.lastname: Leliveld
authors.forename: Benjamin H J
authors.initials: BH
authors.lastname: Doornweerd
authors.forename: Esther
authors.initials: E
authors.lastname: Bastiaannet
authors.forename: Michael
authors.initials: M
authors.lastname: Schaapveld
authors.forename: Igle J
authors.initials: IJ
authors.lastname: de Jong
mesh_terms: D000368:Aged; D015897:Comorbidity; D015653:Cystectomy / Q000401:mortality*; D005260:Female; D019538:Health Care Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000473:pathology; D009361:Neoplasm Invasiveness; D009426:Netherlands / Q000453:epidemiology; D012042:Registries / Q000706:statistics & numerical data; D012189:Retrospective Studies; D016019:Survival Analysis; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000401:mortality* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*
references.citation: J Clin Oncol. 2001 Feb 1;19(3):666-75
references.pmid: 11157016
references.citation: Eur Urol. 2009 Sep;56(3):430-42
references.pmid: 19576682
references.citation: J Chronic Dis. 1987;40(5):373-83
references.pmid: 3558716
references.citation: Cancer. 1997 Nov 1;80(9):1803-4
references.pmid: 9351551
references.citation: Cancer. 1998 Jul 1;83(1):141-7
references.pmid: 9655304
references.citation: Cancer. 2005 Jul 1;104(1):36-43
references.pmid: 15912515
references.citation: Cancer. 2005 Oct 15;104(8):1638-47
references.pmid: 16130136
references.citation: Urology. 2000 Jun;55(6):876-80
references.pmid: 10840099
references.citation: Eur Urol. 2004 Oct;46(4):457-61
references.pmid: 15363560
references.citation: Eur Urol. 2005 Jun;47(6):773-8; discussion 778-9
references.pmid: 15925072
references.citation: J Am Geriatr Soc. 2005 Mar;53(3):424-9
references.pmid: 15743284
references.citation: Urology. 2005 Dec;66(6 Suppl 1):4-34
references.pmid: 16399414
references.citation: J Urol. 2001 Jul;166(1):19-23
references.pmid: 11435814
references.citation: Eur Urol. 2005 Aug;48(2):239-45
references.pmid: 16005375
references.citation: J Clin Oncol. 2006 Aug 20;24(24):3967-72
references.pmid: 16864855
references.citation: J Urol. 2001 Apr;165(4):1111-6
references.pmid: 11257649
references.citation: J Urol. 2003 May;169(5):1697-701
references.pmid: 12686811
references.citation: J Urol. 2006 Oct;176(4 Pt 1):1354-61; discussion 1361-2
references.pmid: 16952631
references.citation: J Urol. 2005 Jul;174(1):97-102
references.pmid: 15947586
references.citation: Eur Urol. 2008 Aug;54(2):303-14
references.pmid: 18468779
references.citation: Eur Urol. 2009 Apr;55(4):815-25
references.pmid: 19157687
references.citation: BJU Int. 2010 Aug;106(3):342-8
references.pmid: 20002664
references.citation: Crit Rev Oncol Hematol. 2003 Jun 27;46 Suppl:S105-15
references.pmid: 12850531
references.citation: J Urol. 1997 Dec;158(6):2113-7
references.pmid: 9366325
references.citation: Radiother Oncol. 2009 Nov;93(2):352-7
references.pmid: 19457565