[Cardioprotective effect of cytoflavine on a model of doxorubicin-induced cardiomyopathy].
Experimental data on the influence of repeated administration of doxorubicin in a dose of 2.24 mg/kg on the glutathione exchange in heart tissues and erythrocytes of white outbred rats are presented. It was shown that disorders in the natural cytoprotection system caused by the introduction of this cardiotropic agent, can be corrected using a combined preparation of cytoflavin.
Kashuro
V A
VA
Glushkov
S I
SI
Novikova
T M
TM
Aksenov
V V
VV
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D002316:Cardiotonic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D019610:Cytoprotection; D004317:Doxorubicin; D004338:Drug Combinations; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005486:Flavin Mononucleotide / Q000494:pharmacology* / Q000627:therapeutic use; D005978:Glutathione / Q000378:metabolism; D007290:Inosine Diphosphate / Q000494:pharmacology* / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009536:Niacinamide / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D013386:Succinates / Q000494:pharmacology* / Q000627:therapeutic use
D002316:Cardiotonic Agents; D004338:Drug Combinations; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D005486:Flavin Mononucleotide; D004317:Doxorubicin; D007290:Inosine Diphosphate; D005978:Glutathione