Trichodermaketones A-D and 7-O-methylkoninginin D from the marine fungus Trichoderma koningii.
Five new polyketide derivatives, 7-O-methylkoninginin D (1) and trichodermaketones A-D (2-5), together with four known compounds, koninginins A, D, E, and F, were isolated from the marine-derived fungus Trichoderma koningii. Trichodermaketones A (2) and B (3) are unprecedented polyketides with a bistetrafuran-containing tricyclic skeleton. The chemical structures and absolute configurations of compounds 1-5 were elucidated by comparing with literature data and extensive spectroscopic methods, including 2D NMR and CD spectroscopic analysis. Compounds 1-5 were evaluated for action against bacteria and fungi and for synergistic antifungal activity. Compound 2 showed synergistic antifungal activity against Candida albicans with 0.05 microg/mL ketoconazole.
Song
Fuhang
F
Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China.
Dai
Huanqin
H
Tong
Yaojun
Y
Ren
Biao
B
Chen
Caixia
C
Sun
Nuo
N
Liu
Xiangyang
X
Bian
Jiang
J
Liu
Mei
M
Gao
Hong
H
Liu
Hongwei
H
Chen
Xiaoping
X
Zhang
Lixin
L
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D007654:Ketoconazole / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D014242:Trichoderma / Q000737:chemistry*
C549947:7-O-methylkoninginin D; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001578:Benzopyrans; D018942:Macrolides; D007654:Ketoconazole