Modulating effects of calcium on immune response of homoiothermal animal under thermoneutral conditions and during deep cooling.
Preliminary ionophoretic administration of Ca(2+) ions into the skin prevents the inhibitory effects of deep cooling on some processes characterizing the immune response. Differently directed changes in some immune response parameters induced by exogenous calcium and deep cooling suggest that competitive interactions between calcium-dependent processes can serve as mechanisms of functional changes in various physiological systems during the formation of the systemic reaction of a homoiothermal organism to cold.
Kozyreva
T V
TV
Laboratory Thermophysiology of Research Institute of Physiology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. kozyreva@physiol.ru
Eliseeva
L S
LS
Khramova
G M
GM
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001833:Body Temperature Regulation; D002118:Calcium / Q000494:pharmacology*; D003080:Cold Temperature / Q000009:adverse effects*; D006388:Hemagglutinins / Q000097:blood; D007155:Immunologic Factors / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012397:Rosette Formation; D012881:Skin Temperature
D006388:Hemagglutinins; D007155:Immunologic Factors; D002118:Calcium