Computational study of pulsatile blood flow in prototype vessel geometries of coronary segments.
The spatial and temporal distributions of wall shear stress (WSS) in prototype vessel geometries of coronary segments are investigated via numerical simulation, and the potential association with vascular disease and specifically atherosclerosis and plaque rupture is discussed. In particular, simulation results of WSS spatio-temporal distributions are presented for pulsatile, non-Newtonian blood flow conditions for: (a) curved pipes with different curvatures, and (b) bifurcating pipes with different branching angles and flow division. The effects of non-Newtonian flow on WSS (compared to Newtonian flow) are found to be small at Reynolds numbers representative of blood flow in coronary arteries. Specific preferential sites of average low WSS (and likely atherogenesis) were found at the outer regions of the bifurcating branches just after the bifurcation, and at the outer-entry and inner-exit flow regions of the curved vessel segment. The drop in WSS was more dramatic at the bifurcating vessel sites (less than 5% of the pre-bifurcation value). These sites were also near rapid gradients of WSS changes in space and time - a fact that increases the risk of rupture of plaque likely to develop at these sites. The time variation of the WSS spatial distributions was very rapid around the start and end of the systolic phase of the cardiac cycle, when strong fluctuations of intravascular pressure were also observed. These rapid and strong changes of WSS and pressure coincide temporally with the greatest flexion and mechanical stresses induced in the vessel wall by myocardial motion (ventricular contraction). The combination of these factors may increase the risk of plaque rupture and thrombus formation at these sites.
Chaniotis
A K
AK
Department of Naval Architecture and Marine Engineering, National Technical University of Athens, P.O. Box 64033, Zografos 15710, Athens, Greece. chaniotis@naval.ntua.gr <chaniotis@naval.ntua.gr>
Kaiktsis
L
L
Katritsis
D
D
Efstathopoulos
E
E
Pantos
I
I
Marmarellis
V
V
D000465:Algorithms; D001794:Blood Pressure / Q000502:physiology; D003198:Computer Simulation; D003323:Coronary Aneurysm / Q000473:pathology / Q000503:physiopathology; D003324:Coronary Artery Disease / Q000473:pathology / Q000503:physiopathology; D003328:Coronary Thrombosis / Q000473:pathology / Q000503:physiopathology; D003331:Coronary Vessels / Q000033:anatomy & histology* / Q000502:physiology*; D006801:Humans; D008955:Models, Cardiovascular; D009200:Myocardial Contraction / Q000502:physiology; D010507:Periodicity; D010974:Platelet Aggregation / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology*; D013314:Stress, Mechanical; D013997:Time Factors; D016276:Ventricular Function / Q000502:physiology
Magn Reson Med. 1996 Apr;35(4):577-84
8992209
Med Eng Phys. 2008 Jan;30(1):9-19
17412633
Eur J Vasc Endovasc Surg. 1999 Oct;18(4):328-33
10550268
Hypertension. 1996 Mar;27(3 Pt 2):799-803
8613243
J Biomech. 2006;39(6):1116-28
16549100
J Biomech. 2004 May;37(5):709-20
15047000
Ann N Y Acad Sci. 2000 May;902:230-9; discussion 239-40
10865843
Circ Res. 1990 Apr;66(4):1045-66
2317887
Ann Biomed Eng. 2003 Apr;31(4):420-9
12723683
Comput Biomed Res. 1997 Feb;30(1):61-82
9134307
Prog Biophys Mol Biol. 2003 Apr;81(3):177-99
12732261
Circulation. 2006 Jun 13;113(23):2744-53
16754802
J Am Coll Cardiol. 1994 Mar 15;23(4):879-84
8106692
J Am Coll Cardiol. 1994 May;23(6):1289-95
8176085
Pathophysiol Haemost Thromb. 2005;34(6):255-62
16772736
Arterioscler Thromb Vasc Biol. 2006 Mar;26(3):663-9
16385083
AJR Am J Roentgenol. 2000 Jun;174(6):1657-65
10845502
Circulation. 2003 Jul 29;108(4):438-44
12860915
Stroke. 2002 Oct;33(10):2446-50
12364736
Proc R Soc Lond B Biol Sci. 1971 Feb 16;177(1046):109-59
4396262
Circulation. 1995 May 1;91(9):2488-96
7729036
Ann Biomed Eng. 2002 Apr;30(4):524-36
12086003
J Biomech. 1982;15(5):349-62
7118950
Arterioscler Thromb Vasc Biol. 1997 Oct;17(10):2061-5
9351372
J Biomech. 2002 Oct;35(10):1347-56
12231280
J Biomech Eng. 1996 Feb;118(1):74-82
8833077
Biorheology. 1994 Sep-Oct;31(5):565-86
7833458
Ann Biomed Eng. 1998 Nov-Dec;26(6):944-54
9846933
Bull Math Biol. 1984;46(1):127-37
6713148
J Biomech. 2006;39(4):742-9
16439244
Cardiovasc Res. 1980 Oct;14(10):568-76
7214391
J Biomech. 2006;39(2):339-47
16321636
Cardiovasc Res. 1989 Sep;23(9):741-7
2611812
Histochem Cell Biol. 2004 Oct;122(4):353-67
15338226
Arteriosclerosis. 1985 May-Jun;5(3):293-302
3994585
Curr Atheroscler Rep. 2004 Jul;6(4):281-7
15191702
J Clin Invest. 1986 Dec;78(6):1456-61
3491092
Med Hypotheses. 2000 Dec;55(6):480-4
11090294
Arterioscler Thromb Vasc Biol. 1998 May;18(5):708-16
9598828
Am J Cardiol. 1990 Dec 1;66(19):1368-72
2244569
Circ Res. 1983 Oct;53(4):502-14
6627609
Ann Biomed Eng. 2004 Dec;32(12):1628-41
15675676
Stroke. 1997 May;28(5):993-8
9158640
JAMA. 1999 Dec 1;282(21):2035-42
10591386
J Biomech Eng. 1992 Aug;114(3):274-82
1522720
Biochem Biophys Res Commun. 2006 Mar 24;341(4):1244-51
16466697
J Biol Chem. 1995 Oct 6;270(40):23352-61
7559492
J Am Coll Cardiol. 2005 Mar 15;45(6):846-54
15766817
Am Heart J. 2002 Jun;143(6):931-9
12075241
J Biomech. 1993 Feb;26(2):133-42
8429056
Lab Invest. 2005 Jan;85(1):9-23
15568038
J Biomech. 2003 Aug;36(8):1185-96
12831745
Ann Biomed Eng. 1994 Sep-Oct;22(5):445-55
7825747
Phys Med Biol. 2003 Jan 7;48(1):127-38
12564505
Am J Physiol. 1980 Jul;239(1):H14-21
7396013
Curr Opin Cardiol. 2000 Nov;15(6):430-40
11198626
Blood. 1996 Sep 1;88(5):1525-41
8781407
J Biomech. 2003 May;36(5):681-8
12694998
Circ Res. 1968 Feb;22(2):165-97
5639037
Ann Biomed Eng. 2006 Mar;34(3):393-407
16477502
Clin Sci. 1971 Feb;40(2):5P
5548533
Science. 1986 Jan 24;231(4736):405-7
3941904
Yonsei Med J. 1998 Apr;39(2):166-74
9587258
Arterioscler Thromb. 1991 Nov-Dec;11(6):1844-52
1931886
Ann Biomed Eng. 1995 Nov-Dec;23(6):787-93
8572428
Circulation. 1993 Apr;87(4):1179-87
8462145
Am J Cardiol. 1994 Mar 1;73(7):431-7
8141082
Physiol Rev. 1995 Jul;75(3):519-60
7624393
Stroke. 1984 Jan-Feb;15(1):50-6
6695430
Arteriosclerosis. 1989 Nov-Dec;9(6):842-7
2590063
Atherosclerosis. 1993 Jan 25;98(2):193-9
7681291