Connecting genes to brain in the autism spectrum disorders.
The autism spectrum disorders (ASDs) are a complex group of neuropsychiatric conditions involving language, social communication, and mental flexibility. Here, we attempt to place recent genetic advances within a developmental and anatomical context. Recent progress in identifying ASD candidate genes supports involvement of multiple brain regions, including the frontal lobes, anterior temporal lobes, caudate, and cerebellum. Understanding genetic data within an anatomical context will be critical to explain how individual risk factors operate to shape phenotypic presentation in patients.
Abrahams
Brett S
BS
Neurogenetics Program, Neurology Department, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095-1769, USA.
Geschwind
Daniel H
DH
D000818:Animals; D001921:Brain / Q000002:abnormalities / Q000254:growth & development / Q000503:physiopathology*; D001923:Brain Chemistry / Q000235:genetics*; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology*; D004195:Disease Models, Animal; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D055106:Genome-Wide Association Study / Q000639:trends*; D006801:Humans; D009421:Nervous System Malformations / Q000235:genetics; D010641:Phenotype; D012920:Social Behavior Disorders / Q000235:genetics / Q000473:pathology / Q000503:physiopathology
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