title: Decision-making, behavioral supervision and learning: an executive role for the ventral premotor cortex?
abstract: In order to adjust the behavioral performance in a changing environment, subjects have to monitor their evolving actions and to know whether their responses were correct or incorrect. This requires self-awareness, cognitive flexibility, working memory (WM), and decision making that frequently are impaired in psychosis. What is the neural substrate of these processes and where are these substrates located? Dysfunction of prefrontal, parietal, temporal cortices, and associated subcortical structures are known to be involved in some of these symptoms. The prefrontal-subcortical circuits have been the main focus of study while other cortical areas such as the premotor cortex have received less attention. The main focus of this review is about the evidence that the ventral premotor cortex processes both recent sensory information and that from long-term memory to decide and evaluate the behavior of previous decisions. This process may serve for learning and thus adapting future behavior to environmental demands. Therefore, dysfunction of this cortical area could be related to some cognitive neuropsychiatric disorders.
authors.affiliation: Laboratorios de Neurociencia, Departamento de Fisiología, Facultad de Medicina and Complejo Hospitalario Universitario, Universidad de Santiago de Compostela, 15705, Santiago de Compostela, Spain. carlos.acuna.castroviejo@usc.es
authors.forename: C
authors.initials: C
authors.lastname: Acuña
authors.forename: J L
authors.initials: JL
authors.lastname: Pardo-Vázquez
authors.forename: V
authors.initials: V
authors.lastname: Leborán
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D003657:Decision Making / Q000502:physiology*; D056344:Executive Function / Q000502:physiology*; D006801:Humans; D007858:Learning / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology; D017397:Prefrontal Cortex / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology*
references.citation: Ann N Y Acad Sci. 2007 Dec;1121:499-527
references.pmid: 17872395
references.citation: J Neurosci. 2008 Nov 19;28(47):12396-408
references.pmid: 19020032
references.citation: Prog Brain Res. 1990;85:63-94
references.pmid: 2094916
references.citation: J Comp Neurol. 1986 Jun 8;248(2):164-89
references.pmid: 3722457
references.citation: J Neurosci. 1996 Feb 15;16(4):1486-510
references.pmid: 8778300
references.citation: J Comp Neurol. 2006 Apr 1;495(4):374-90
references.pmid: 16485282
references.citation: Electroencephalogr Clin Neurophysiol. 1991 Jun;78(6):447-55
references.pmid: 1712280
references.citation: Exp Brain Res. 1988;71(3):475-90
references.pmid: 3416964
references.citation: World Psychiatry. 2007 Jun;6(2):92-3
references.pmid: 18235859
references.citation: Science. 1993 Feb 5;259(5096):819-21
references.pmid: 7679223
references.citation: Cereb Cortex. 2006 Aug;16(8):1057-68
references.pmid: 16221929
references.citation: Science. 2004 Oct 15;306(5695):443-7
references.pmid: 15486290
references.citation: J Neurophysiol. 2007 Dec;98(6):3548-56
references.pmid: 17942629
references.citation: J Neurophysiol. 2008 Jul;100(1):520-5
references.pmid: 18480374
references.citation: Behav Cogn Neurosci Rev. 2002 Jun;1(2):108-29
references.pmid: 17715589
references.citation: J Neurosci. 2007 Dec 26;27(52):14502-14
references.pmid: 18160658
references.citation: Eur J Neurosci. 2006 Aug;24(3):925-36
references.pmid: 16930420
references.citation: Cereb Cortex. 2003 Nov;13(11):1208-18
references.pmid: 14576212
references.citation: J Comp Neurol. 1990 Jun 15;296(3):462-95
references.pmid: 2358548
references.citation: Neuropsychopharmacology. 2006 Feb;31(2):297-309
references.pmid: 16012531
references.citation: J Neurosci. 1983 Dec;3(12):2563-86
references.pmid: 6655500
references.citation: J Comp Neurol. 1999 Jun 21;409(1):131-52
references.pmid: 10363716
references.citation: J Neurophysiol. 2006 Feb;95(2):709-29
references.pmid: 16251265
references.citation: Science. 1989 Jan 13;243(4888):234-6
references.pmid: 2911737
references.citation: Neuron. 2009 Mar 26;61(6):930-40
references.pmid: 19324001
references.citation: Somatosens Mot Res. 1995;12(3-4):359-78
references.pmid: 8834308
references.citation: J Neurosci. 2009 Jun 10;29(23):7526-39
references.pmid: 19515921
references.citation: BMC Neurosci. 2005 Nov 25;6:67
references.pmid: 16309550
references.citation: Neuron. 2002 Mar 14;33(6):959-72
references.pmid: 11906701
references.citation: Science. 1999 Mar 12;283(5408):1752-7
references.pmid: 10073944
references.citation: Proc Natl Acad Sci U S A. 1999 Aug 31;96(18):10418-21
references.pmid: 10468623
references.citation: Exp Brain Res. 2004 Sep;158(1):28-34
references.pmid: 15042265
references.citation: Proc Natl Acad Sci U S A. 2009 Nov 3;106(44):18815-9
references.pmid: 19846763
references.citation: Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9985-90
references.pmid: 8790444
references.citation: J Neurophysiol. 2001 Oct;86(4):1916-36
references.pmid: 11600651
references.citation: Exp Brain Res. 1991;85(3):491-500
references.pmid: 1915708
references.citation: J Neurosci. 1992 Jul;12(7):2542-8
references.pmid: 1613546
references.citation: J Neurophysiol. 2000 May;83(5):2639-48
references.pmid: 10805664
references.citation: Cognition. 2002 Sep;85(2):177-87
references.pmid: 12127698
references.citation: Proc Natl Acad Sci U S A. 2006 Sep 26;103(39):14266-71
references.pmid: 16924098
references.citation: Cereb Cortex. 1994 Sep-Oct;4(5):470-83
references.pmid: 7530521
references.citation: J Comp Neurol. 1994 Mar 15;341(3):375-92
references.pmid: 7515081
references.citation: J Physiol. 1968 Mar;195(1):215-43
references.pmid: 4966457
references.citation: Nat Neurosci. 2004 Apr;7(4):404-10
references.pmid: 15004564
references.citation: Physiol Behav. 2002 Dec;77(4-5):677-82
references.pmid: 12527018
references.citation: J Neurosci. 2003 Sep 10;23(23):8432-44
references.pmid: 12968006
references.citation: Trends Neurosci. 1992 Jan;15(1):20-5
references.pmid: 1374953
references.citation: Nat Rev Neurosci. 2003 Mar;4(3):203-18
references.pmid: 12612633
references.citation: J Comp Neurol. 1986 Sep 15;251(3):281-98
references.pmid: 3021823
references.citation: Nat Neurosci. 2002 Mar;5(3):267-71
references.pmid: 11865311
references.citation: Nature. 2000 Dec 14;408(6814):857-60
references.pmid: 11130724
references.citation: Exp Brain Res. 1999 Sep;128(1-2):181-7
references.pmid: 10473756
references.citation: Neuron. 2004 Jan 8;41(1):165-73
references.pmid: 14715143
references.citation: J Neurosci. 2007 Dec 12;27(50):13750-5
references.pmid: 18077686
references.citation: Brain. 1998 May;121 ( Pt 5):785-99
references.pmid: 9619185
references.citation: Cogn Affect Behav Neurosci. 2001 Jun;1(2):137-60
references.pmid: 12467110
references.citation: Cereb Cortex. 1995 Sep-Oct;5(5):429-38
references.pmid: 8547789
references.citation: J Neurosci. 1999 Feb 15;19(4):1446-63
references.pmid: 9952421
references.citation: J Neurophysiol. 2000 May;83(5):2580-601
references.pmid: 10805659
references.citation: Science. 1994 Nov 11;266(5187):1054-7
references.pmid: 7973661
references.citation: Curr Opin Neurobiol. 2006 Apr;16(2):191-8
references.pmid: 16531040
references.citation: Trends Neurosci. 1995 Jul;18(7):314-20
references.pmid: 7571012
references.citation: Cereb Cortex. 2004 Aug;14(8):872-80
references.pmid: 15054060
references.citation: Nature. 1996 Aug 15;382(6592):629-32
references.pmid: 8757133
references.citation: J Neurophysiol. 1992 Sep;68(3):969-72
references.pmid: 1432062
references.citation: Neuron. 2004 Jan 22;41(2):301-7
references.pmid: 14741110
references.citation: Science. 1973 Dec 21;182(4118):1275-8
references.pmid: 4752222
references.citation: J Neurophysiol. 2005 Oct;94(4):2457-71
references.pmid: 15958600
references.citation: Cereb Cortex. 2007 Sep;17 Suppl 1:i110-7
references.pmid: 17548802
references.citation: Annu Rev Neurosci. 2004;27:169-92
references.pmid: 15217330
references.citation: Brain. 2001 Mar;124(Pt 3):571-86
references.pmid: 11222457
references.citation: Brain. 1990 Feb;113 ( Pt 1):207-22
references.pmid: 2302533
references.citation: Science. 1971 Aug 13;173(3997):652-4
references.pmid: 4998337
references.citation: J Neurosci. 2006 Mar 22;26(12):3330-4
references.pmid: 16554483
references.citation: Schizophr Bull. 1991;17(1):113-32
references.pmid: 2047782
references.citation: Nature. 1996 Oct 17;383(6601):618-21
references.pmid: 8857536
references.citation: J Vis. 2005 May 02;5(5):376-404
references.pmid: 16097871
references.citation: Science. 2003 Oct 3;302(5642):120-2
references.pmid: 14526085
references.citation: Science. 2004 Jan 16;303(5656):380-3
references.pmid: 14726593
references.citation: Trends Cogn Sci. 2004 Dec;8(12):539-46
references.pmid: 15556023
references.citation: Brain Res. 1978 Jan 13;139(2):309-26
references.pmid: 414819
references.citation: Science. 1999 Mar 12;283(5408):1657-61
references.pmid: 10073923
references.citation: Science. 2005 Feb 18;307(5712):1059-60
references.pmid: 15718459
references.citation: Exp Brain Res. 1984;56(3):410-24
references.pmid: 6094229
references.citation: J Neurosci. 1984 Feb;4(2):539-60
references.pmid: 6199485
references.citation: Cereb Cortex. 2008 May;18(5):1094-111
references.pmid: 17720686
references.citation: Nat Neurosci. 2007 May;10(5):647-56
references.pmid: 17450137
references.citation: J Neurophysiol. 1975 Jul;38(4):871-908
references.pmid: 808592
references.citation: Behav Brain Res. 2002 Sep 20;135(1-2):105-18
references.pmid: 12356440
references.citation: Science. 2003 Nov 14;302(5648):1181-5
references.pmid: 14615530
references.citation: Exp Brain Res. 1991;84(3):668-71
references.pmid: 1864337
references.citation: Neuron. 2001 Sep 27;31(6):889-901
references.pmid: 11580891
references.citation: Science. 2007 Oct 26;318(5850):602-6
references.pmid: 17962553
references.citation: Brain Res. 2007 Nov 14;1180:90-100
references.pmid: 17905200
references.citation: Cortex. 2006 May;42(4):521-4
references.pmid: 16881263
references.citation: Vis Neurosci. 1996 Jan-Feb;13(1):87-100
references.pmid: 8730992
references.citation: Psychol Rev. 2002 Oct;109(4):679-709
references.pmid: 12374324
references.citation: Int J Neurosci. 1987 Dec;37(3-4):127-48
references.pmid: 3121528
references.citation: Curr Opin Neurobiol. 2003 Apr;13(2):204-11
references.pmid: 12744975
references.citation: Brain Behav Evol. 1989;33(2-3):189-92
references.pmid: 2758301
references.citation: J Neurosci. 2009 Mar 18;29(11):3627-41
references.pmid: 19295166
references.citation: J Neurosci. 1986 Jul;6(7):2054-63
references.pmid: 3734876
references.citation: Science. 2004 Aug 6;305(5685):875-7
references.pmid: 15232072
references.citation: Annu Rev Neurosci. 2007;30:535-74
references.pmid: 17600525
references.citation: J Neurosci. 2008 Dec 17;28(51):13775-85
references.pmid: 19091968
references.citation: J Neurosci. 2009 Aug 5;29(31):9861-74
references.pmid: 19657038
references.citation: Science. 2004 Feb 13;303(5660):1023-6
references.pmid: 14963333
references.citation: Neuron. 2009 Jul 30;63(2):244-53
references.pmid: 19640482
references.citation: Neuron. 2008 Jan 24;57(2):314-25
references.pmid: 18215627