Synthesis of novel benzocoumarin derivatives as lipid lowering agents.
A series of novel benzocoumarin derivatives were synthesized and evaluated for their in vivo anti-dyslipidemic and in vitro antioxidant activities. Preliminary screening indicates compound 4 as potential lead with significant lipid lowering and antioxidant activities. The study revealed that such attempts on benzocoumarin-based pharmacophores which is a biologically important scaffold might result in identification of new lead for anti-dyslipidemia.
Sashidhara
Koneni V
KV
Medicinal and Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow 226 001, India. sashidhar123@gmail.com
Rosaiah
Jammikuntla N
JN
Kumar
Abdhesh
A
Bhatia
Gitika
G
Khanna
A K
AK
D000818:Animals; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry* / Q000627:therapeutic use; D006949:Hyperlipidemias / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D051381:Rats; D013329:Structure-Activity Relationship
C551142:7-benzyloxy-4-methyl-benzo(h)chromen-2-one; D003374:Coumarins; D000960:Hypolipidemic Agents; C030123:coumarin