title: G 1359A polymorphism of the cannabinoid receptor gene (CNR1) and clinical results of biliopancreatic diversion.
abstract: BACKGROUND
  Bariatric surgery is the most effective long-term treatment for morbid obesity, reducing obesity-associated co-morbidities. We decide to investigate the role of the polymorphism (G1359A) of the cannabinoid (CB)1 receptor gene on clinical outcomes 1 year after biliopancreatic diversion in morbidly obese patients.
  
  
  METHODS
  A sample of 66 morbidly obese patients (BMI >40 kg/m2) were operated. Weight, fat mass, blood pressure, basal glucose, triacylglycerols, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol were measured at basal visit and at each visit. The frequency of metabolic comorbidities was recorded at each visit.
  
  
  RESULTS
  Thirty-nine patients (59.1%) had genotype G1359G (wild type group) and 27 (40.9%) patients had genotype G1359A (mutant type group). In wild and mutant type groups, body mass index, weight, waist circumference, systolic blood pressure, glucose, total cholesterol, low-density lipoprotein cholesterol and triacylglycerols concentrations decreased, without statistical between genotype groups. Initial weight percent loss at 1 year of follow up was similar in both genotypes (33.1% vs 33.6%; ns).
  
  
  CONCLUSIONS
  The present study demonstrates that polymorphism G1359A in the CB1 receptor did not have a significant effect on biochemical and anthropometric improvements after biliopancreatic diversion surgery.
authors.affiliation: Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain. dadluis@yahoo.es
authors.forename: D A
authors.initials: DA
authors.lastname: de Luis
authors.forename: D
authors.initials: D
authors.lastname: Pacheco
authors.forename: R
authors.initials: R
authors.lastname: Aller
authors.forename: M
authors.initials: M
authors.lastname: Gonzalez Sagrado
authors.forename: R
authors.initials: R
authors.lastname: Conde
authors.forename: O
authors.initials: O
authors.lastname: Izaola
authors.forename: L
authors.initials: L
authors.lastname: Cuellar
authors.forename: M C
authors.initials: MC
authors.lastname: Terroba
authors.forename: T
authors.initials: T
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: Ventosa
mesh_terms: D000328:Adult; D050110:Bariatric Surgery; D015904:Biliopancreatic Diversion; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D015992:Body Mass Index; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000097:blood / Q000235:genetics / Q000503:physiopathology / Q000601:surgery*; D010641:Phenotype; D011110:Polymorphism, Genetic; D043884:Receptor, Cannabinoid, CB1 / Q000235:genetics*; D013997:Time Factors; D016896:Treatment Outcome; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D043884:Receptor, Cannabinoid, CB1