title: Primary signet-ring cell adenocarcinoma of the endometrium: case report and review of the literature.
abstract: Endometrial adenocarcinoma presenting with deep venous thrombosis is an exceptional event more typical of extra-mullerian primary tumors. Metastases to the spleen are also unusual in this setting. In addition, primary endometrial adenocarcinoma with signet-ring cell features has been reported only once. This study describes a case of primary endometrial carcinoma with prominent signet-ring cell features that presented in an unusual manner: with bilateral deep vein thromboses and splenic metastases. It is important for clinicians and pathologists to be aware of this entity; it may have an atypical clinical presentation and the histologic features raise a spectrum of differential diagnoses.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Calgary, and Calgary Laboratory Services, 11th Floor, Foothills Medical Center, 1403-29 Street NW, Calgary, Alberta, Canada T2N 2T9. ichebib@ucalgary.ca
authors.forename: Ivan
authors.initials: I
authors.lastname: Chebib
authors.forename: Pamela
authors.initials: P
authors.lastname: Chu
authors.forename: Maire A
authors.initials: MA
authors.lastname: Duggan
authors.forename: Lisa M
authors.initials: LM
authors.lastname: DiFrancesco
mesh_terms: D018279:Carcinoma, Signet Ring Cell / Q000097:blood / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D016889:Endometrial Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D013160:Splenic Neoplasms / Q000097:blood / Q000556:secondary* / Q000601:surgery; D020246:Venous Thrombosis / Q000473:pathology*