Overview of the biology of type I interferons.
Type I interferons are pleiotropic cytokines with antiviral, antitumor and immunoregulatory functions. An aspect of their complex biology is the paradox that, depending on context, type I interferons can be anti-inflammatory and tissue protective or can be proinflammatory and promote autoimmunity. Along these lines, the activation of type I interferon pathways is effective in suppressing disease activity in patients with multiple sclerosis and in animal models of arthritis and colitis, while there is an expectation that blockade of the same pathways will be beneficial in the treatment of patients with systemic lupus erythematosus.
Kalliolias
George D
GD
Arthritis and Tissue Degeneration Program and Department of Medicine, Hospital for Special Surgery, 535 East 70th Street, New York, NY 10021, USA.
Ivashkiv
Lionel B
LB
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D004195:Disease Models, Animal; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D015212:Inflammatory Bowel Diseases / Q000188:drug therapy; D007370:Interferon Type I / Q000009:adverse effects / Q000145:classification / Q000502:physiology* / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000473:pathology / Q000503:physiopathology; D009103:Multiple Sclerosis / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy; D053633:Receptor, Interferon alpha-beta / Q000502:physiology; D050791:STAT Transcription Factors / Q000378:metabolism; D015398:Signal Transduction; D014714:Vertebrates / Q000378:metabolism; D014777:Virus Diseases / Q000188:drug therapy / Q000503:physiopathology
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D007155:Immunologic Factors; D007370:Interferon Type I; D050791:STAT Transcription Factors; D053633:Receptor, Interferon alpha-beta
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