title: Lithium cadmate-mediated deprotonative metalation of anisole: experimental and computational study.
abstract: Lithium cadmates bearing different ligands were compared with efficient (TMP)(3)CdLi (TMP = 2,2,6,6-tetramethylpiperidino) for their ability to deprotometalate anisole. The generated arylcadmates were evidenced using I(2). The results show that it is possible to replace only one of the TMP (with a piperidino, a diisopropylamino, a butyl, or a sec-butyl) without important yield drop. In the light of DFT calculations, reaction pathways were proposed for the deprotocadmations of anisole using a triamino, an alkyldiamino, and an aminodialkyl cadmate.
authors.affiliation: Chimie et Photonique Moléculaires, UMR 6510 CNRS, Université de Rennes 1, Bâtiment 10A, Case 1003, Campus Scientifique de Beaulieu, 35042 Rennes, France.
authors.forename: Katia
authors.initials: K
authors.lastname: Snégaroff
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Komagawa
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Yonehara
authors.forename: Floris
authors.initials: F
authors.lastname: Chevallier
authors.forename: Philippe C
authors.initials: PC
authors.lastname: Gros
authors.forename: Masanobu
authors.initials: M
authors.lastname: Uchiyama
authors.forename: Florence
authors.initials: F
authors.lastname: Mongin