Plasmodium falciparum isolates with increased pfmdr1 copy number circulate in West Africa.
Amplification of pfmdr1 in Plasmodium falciparum is linked to resistance to aryl-amino-alcohols and in reduced susceptibility to artemisinins. We demonstrate here that duplicated pfmdr1 genotypes circulate in West Africa. The monitoring of this prevalence in Africa appears essential for determining the antimalarial policy and to maintain the efficiency of artemisinin-based combination therapy (ACT) for as long as possible.
Witkowski
Benoit
B
Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire de Toulouse, Toulouse, France.
Nicolau
Marie-Laure
ML
Soh
Patrice Njomnang
PN
Iriart
Xavier
X
Menard
Sandie
S
Alvarez
Muriel
M
Marchou
Bruno
B
Magnaval
Jean-François
JF
Benoit-Vical
Françoise
F
Berry
Antoine
A
D000349:Africa; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D037621:Artemisinins / Q000627:therapeutic use; D018628:Gene Dosage; D005838:Genotype; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology; D027425:ATP-Binding Cassette, Sub-Family C Proteins / Q000235:genetics*; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000235:genetics* / Q000472:pathogenicity
D000962:Antimalarials; D037621:Artemisinins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C513498:Mdr1 protein, Plasmodium falciparum
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