title: Favorable glucose tolerance and lower prevalence of metabolic syndrome in offspring without diabetes mellitus of nonagenarian siblings: the Leiden longevity study.
abstract: OBJECTIVE
  To explore measures of metabolic syndrome and glucose metabolism in families with exceptional longevity.
  
  
  METHODS
  Case-control study.
  
  
  METHODS
  A university hospital in Leiden, the Netherlands.
  
  
  METHODS
  One hundred twenty-one offspring of nonagenarian siblings, who were enriched for familial factors promoting longevity, and 113 of their partners. No subject had diabetes mellitus.
  
  
  METHODS
  Prevalence of metabolic syndrome was determined according to the criteria of the Third Report of the National Cholesterol Education Program. Glucose tolerance was assessed according to a 2-hour oral glucose tolerance test.
  
  
  RESULTS
  The offspring of nonagenarians siblings had a lower prevalence of metabolic syndrome (P=.03), similar body composition, lower mean fasting blood glucose levels (4.99 vs 5.16 mmol/L; P=.01), lower mean fasting insulin levels (5.81 vs 6.75 mU/L; P=.04), a higher mean homeostasis model assessment of insulin sensitivity (0.78 vs 0.65; P=.02), and a more-favorable glucose tolerance (mean area under the receiver operating characteristic curve for glucose (13.2 vs 14.3; P=.007) than their partners. No significant differences were observed between the offspring and their partners in beta-cell function (insulogenic index 13.6 vs 12.5; P=.38).
  
  
  CONCLUSIONS
  Despite similar body composition, the offspring of nonagenarian siblings showed a lower prevalence of metabolic syndrome and better glucose tolerance than their partners, centralizing the role of favorable glucose metabolism in familial longevity.
authors.affiliation: Gerontology and Geriatrics, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, the Netherlands.
authors.forename: Maarten P
authors.initials: MP
authors.lastname: Rozing
authors.forename: Rudi G J
authors.initials: RG
authors.lastname: Westendorp
authors.forename: Anton J M
authors.initials: AJ
authors.lastname: de Craen
authors.forename: Marijke
authors.initials: M
authors.lastname: Frölich
authors.forename: Moniek C M
authors.initials: MC
authors.lastname: de Goeij
authors.forename: Bastiaan T
authors.initials: BT
authors.lastname: Heijmans
authors.forename: Marian
authors.initials: M
authors.lastname: Beekman
authors.forename: Carolien A
authors.initials: CA
authors.lastname: Wijsman
authors.forename: Simon P
authors.initials: SP
authors.lastname: Mooijaart
authors.forename: Gerard-Jan
authors.initials: GJ
authors.lastname: Blauw
authors.forename: P Eline
authors.initials: PE
authors.lastname: Slagboom
authors.forename: Diana
authors.initials: D
authors.lastname: van Heemst
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005192:Family Health; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D016014:Linear Models; D008136:Longevity; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology*; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D018454:Spouses