title: [Lifestyle and global cardiovascular risk: a prospective study on a borderline hypertensive population].
abstract: OBJECTIVE
  Arterial hypertension is a well known risk factor for cardiovascular diseases. Today, it is possible to calculate the cardiovascular risk at 10 years with the risk card. The reduction of cardiovascular risk is based on a multi-factorial approach including the lifestyle modification. In Italy, OEC study has calculated that a certain proportion of borderline hypertensives, not eligible for a pharmacological treatment, remain at risk. Borderline arterial hypertension (140-150/90-95 mmHg) in Italian population is documented in 19% of males and 14% of females.: Aim of the study is to examine the efficacy of the lifestyle changes in reducing the global cardiovascular risk in bordeline hypertensives.
  
  
  METHODS
  102 patients affected by borderline hypertensive (46 M and 56 F, mean age: 55.6 yrs ) were enclosed in a 12 months prospective study. Three checks were programmed during the follow-up, i.e., at beginning, 6 months and 12 months later. At the start of the study every patient received a list of lifestyle changes to be respected. Pressure arterial systolic and diastolic were obtained at beginning and at the end of successive. At the last check each patient received a questionnaire to be filled up. According to the calculated score, each patient was classified as: non-responder (score: 0-3), partially responder (score: 4-6), responder (score: 7-9).
  
  
  RESULTS
  A significant reduction of the globalcardiovascular risk has been observed at the end of the study in both the responders and partially responders. Such a reduction was seen to be due to positive changes in blood pressure and total, HDL, LDL cholesterol.
  
  
  CONCLUSIONS
  This study confirmed that a non-pharmacological therapy based on lifestyle changes has to be preventively administered in the presence of a borderline hypertension because of its beneficial effects in reducing the global risk of cardiovascular disease. Therefore, we firmly think that a prompt utilization of a correct lifestyle can sort the triple effect of improving the expectancy of life, ameliorating the quality of life, reducing the social costs of arterial hypertension.
authors.affiliation: Dipartimento di Discipline Chirurgiche e Metodologie Integrate, Universitegli Studi di Genova, Italia. vincenzo.paoletti@uniroma1.it
authors.forename: V
authors.initials: V
authors.lastname: Paoletti
authors.forename: D P
authors.initials: DP
authors.lastname: Loricchio
authors.forename: S
authors.initials: S
authors.lastname: Basili
authors.forename: G
authors.initials: G
authors.lastname: Cavina
authors.forename: G
authors.initials: G
authors.lastname: Labaddia
authors.forename: M
authors.initials: M
authors.lastname: Pacelli
authors.forename: M
authors.initials: M
authors.lastname: Arca
authors.forename: A
authors.initials: A
authors.lastname: Mammarella
mesh_terms: D015415:Biomarkers / Q000097:blood; D001795:Blood Pressure Determination; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology / Q000517:prevention & control; D002319:Cardiovascular System / Q000503:physiopathology; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D015438:Health Behavior; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications* / Q000503:physiopathology / Q000628:therapy*; D008017:Life Expectancy; D008019:Life Style; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000628:therapy; D011446:Prospective Studies; D011788:Quality of Life; D018570:Risk Assessment; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL