Locus-specific dependency of endogenous silent loci on MOM1 and non-CG methylation in Arabidopsis thaliana.
RNA-directed modification of histones is essential for maintenance of heterochromatin in higher eukaryotes. In plants, cytosine methylation, especially in non-CG sequence contexts, is tightly related to inactive chromatin, but the mechanisms regulating the coexistence of cytosine methylation and repressive histone modification remain obscure. We recently revealed that MORPHEUS' MOLECULE1 (MOM1) of Arabidopsis thaliana silences endogenous loci related to transposons and homologous to the 24-nt siRNAs accumulated in wild type plants, and suggested that MOM1 transduces RNA-directed DNA methylation (RdDM) signals to repressive histone modification. In this addendum, we focus on the involvement of MOM1 in multiple transcriptional gene silencing (TGS) pathways.
Habu
Yoshiki
Y
Division of Plant Sciences, National Institute of Agrobiological Sciences, Tsukuba, Japan. habu@affrc.go.jp
Yoshikawa
Manabu
M
Genes Dev. 2008 Jun 15;22(12):1597-606
18559476
EMBO Rep. 2006 Dec;7(12):1273-8
17082821
Nature. 2000 May 11;405(6783):203-6
10821279
Genes Dev. 2006 Apr 1;20(7):759-71
16600909
Plant Cell. 2000 Jul;12(7):1165-78
10899982
EMBO J. 2010 Jan 20;29(2):352-62
20010696
Nat Rev Genet. 2005 Jan;6(1):24-35
15630419
Curr Biol. 2007 Feb 20;17(4):379-84
17239600
EMBO Rep. 2006 Dec;7(12):1279-84
17082818
Cell. 2008 May 2;133(3):523-36
18423832
Nature. 2002 Apr 4;416(6880):556-60
11898023
EMBO J. 2010 Jan 20;29(2):340-51
19910926