In Vitro Antiviral Activity of some Novel Isatin Derivatives against HCV and SARS-CoV Viruses.
4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)benzene sulphonamide and its derivatives were evaluated for antiviral activity against Pathogenic viruses such as Hepatitis C Virus and SARS-CoV in Vero and Huh 5-2 cells, respectively. The 5-fluoro derivative inhibited the HCV RNA synthesis at 6 mug/ml, without toxicity at a concentration up to 42 mug/ml in Huh 5-2 cells. Among the compounds tested SPIII-5F exhibits the 45% maximum protection against replication of SARS-CoV in Vero cells.
Selvam
P
P
Arulmigu Kalasalingam College of Pharmacy, Krishnankoil - 626 190, India.
Murgesh
N
N
Chandramohan
M
M
De Clercq
E
E
Keyaerts
E
E
Vijgen
L
L
Maes
P
P
Neyts
J
J
Ranst
M V
MV
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