Detection of the HE4 protein in urine as a biomarker for ovarian neoplasms.
The HE4 protein is overexpressed in ovarian carcinomas and can be detected in serum by an ELISA with sensitivity similar to CA125 and higher specificity for malignant disease. We now demonstrate that HE4 can also be detected in the urine at a specificity level of 94.4%, including 13/15 (86.6%) with stage I/II and 57/64 (89.0%) with stage III/IV disease and including 90.5% of patients with serous ovarian carcinoma. Assaying serum and urine from the same patients showed similar sensitivity. Our data indicate that measuring HE4 in urine may aid diagnosis and the monitoring of response to therapy.
Hellstrom
Ingegerd
I
Department of Pathology, University of Washington, Seattle, WA 98104, USA. ihellstr@u.washington.edu
Heagerty
Patrick J
PJ
Swisher
Elizabeth M
EM
Liu
Pu
P
Jaffar
Jade
J
Agnew
Kathy
K
Hellstrom
Karl Erik
KE
D015415:Biomarkers / Q000097:blood / Q000652:urine; D003404:Creatinine / Q000097:blood / Q000652:urine; D004797:Enzyme-Linked Immunosorbent Assay; D030501:Epididymal Secretory Proteins / Q000235:genetics* / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D005831:Genital Diseases, Female / Q000097:blood / Q000235:genetics / Q000652:urine; D006801:Humans; D010051:Ovarian Neoplasms / Q000097:blood / Q000235:genetics* / Q000652:urine; D017698:Postmenopause; D017697:Premenopause; D012016:Reference Values; D023083:beta-Defensins
D015415:Biomarkers; C426184:DEFB126 protein, human; D030501:Epididymal Secretory Proteins; D023083:beta-Defensins; D003404:Creatinine
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