Ultrahigh resolution optical coherence tomography with femtosecond Ti:sapphire laser and photonic crystal fiber.
Optical coherence tomography (OCT) with ultrahigh axial resolution was achieved by the super-continuum generated by coupling femtosecond pulses from a commercial Ti:sapphire laser into an air-silica microstructure fiber. The visible spectrum of the super-continuum from 450 to 700 nm centered at 540 nm can be generated. A free-space axial OCT resolution of 0.64 μm was achieved. The sensitivity of OCT system was 108 dB with incident light power 3 mW at sample, only 7dB below the theoretical limit. Subcellular OCT imaging was also demonstrated, showing great potential for biomedical application.
Ping
Xue
X
Department of Physics, Laboratory of Atomic and Molecular Nanosciences of Ministry of Education, Tsinghua University, Beijing 100084, China.
Fujimoto
James G
JG
Opt Lett. 2000 Jan 1;25(1):25-7
18059770
Opt Lett. 2002;27(20):1800-2
18033368
Science. 1991 Nov 22;254(5035):1178-81
1957169
Opt Lett. 2006 Dec 1;31(23):3459-61
17099749
Opt Lett. 2007 Feb 15;32(4):361-3
17356653
Opt Express. 2005 Mar 21;13(6):2182-95
19495106
Opt Lett. 2001 May 1;26(9):608-10
18040398
Opt Lett. 2007 Jun 1;32(11):1587-9
17546197
Opt Lett. 2000 Oct 1;25(19):1415-7
18066233
Opt Express. 2006 Mar 6;14(5):1878-87
19503517