RNA modifications: a mechanism that modulates gene expression.
Accuracy in the flow of genetic information from DNA to protein, or gene expression, is essential to the viability of an organisms. Pre-mRNA splicing and protein translation are two major steps in eukaryotic gene expression that necessitate the production of accurate gene products. Both processes occur in large complexes, consisting of both proteins and noncoding RNAs. Interestingly, the RNA components contain a large number of posttranscriptional modifications, including 2'-O-methylation and pseudouridylation, which are functionally important. In this chapter, we highlight the functional aspects of the modifications of spliceosomal snRNA and rRNA and provide a framework for understanding how posttranscriptional modifications are capable of influencing gene expression.
Karijolich
John
J
Department of Biochemistry and Biophysics, University of Rochester Medical Center, Rochester, NY, USA.
Kantartzis
Athena
A
Yu
Yi-Tao
YT
D000818:Animals; D001483:Base Sequence; D006801:Humans; D008969:Molecular Sequence Data; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics*; D012326:RNA Splicing / Q000235:genetics; D012335:RNA, Ribosomal / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012342:RNA, Small Nuclear / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D017381:Spliceosomes / Q000378:metabolism
D012335:RNA, Ribosomal; D012342:RNA, Small Nuclear
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