Simple quantitative analysis of asbestos body using the sediment of formalin injected into surgically resected lung cancers.
A simple screening method for quantitatively analyzing asbestos bodies that can be carried out even in community hospitals, is needed in order for laborers and neighborhoods in the vicinity of asbestos factories to apply for compensation for asbestos-related injury. Eighty-eight consecutive cases of surgically resected primary lung cancer were analyzed for asbestos bodies using two methods, and the correlation between them was statistically examined. The first was the conventional technique using lung tissue digestion and phase-contrast scanning, and the second was the authors' method using light microscopy to scan the sediment of formalin-injected lung specimens. The overall correlation coefficient of the concentration of asbestos bodies between the authors' method (C(AB/SED)) and the conventional method (C(AB/DLT)) was 0.4576, a weak statistically significant correlation; in patients with occupational asbestos exposure, however, the correlation coefficient was 0.7341. Despite the cost, it may be prudent to use the conventional method under the present law for patients with C(AB/SED)>or=3.5/mL. C(AB/DLT) >3000/g dry lung tissue when C(AB/SED) is >or=3.5/mL suggests the potential for the accumulation of asbestos absorption by lung tissue.
Sakai
Yasuhiro
Y
Department of Pathology, Hyogo Cancer Center, Hyogo, Japan.
Ohbayashi
Chiho
C
Itami
Hiroe
H
Kajimoto
Kazuyoshi
K
Sakuma
Toshiko
T
Uchino
Kazuya
K
Yoshimura
Masahiro
M
Matsumoto
Shoji
S
Idei
Yuka
Y
Oka
Teruaki
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001194:Asbestos / Q000032:analysis*; D019411:Clinical Laboratory Techniques; D005260:Female; D005557:Formaldehyde; D006801:Humans; D008175:Lung Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016273:Occupational Exposure / Q000009:adverse effects
D001194:Asbestos; D005557:Formaldehyde