title: Does cognitive-behavioral therapy response among adults with obsessive-compulsive disorder differ as a function of certain comorbidities?
abstract: This study examines the impact of several of the most common comorbid psychiatric disorders (i.e., generalized anxiety disorder (GAD); major depressive disorder (MDD); social phobia, and panic disorder) on cognitive-behavioral therapy (CBT) response in adults with obsessive-compulsive disorder (OCD). One hundred and forty-three adults with OCD (range=18-79 years) received 14 sessions of weekly or intensive CBT. Assessments were conducted before and after treatment. Primary outcomes included scores on the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), response rates, and remission status. Sixty-nine percent of participants met criteria for at least one comorbid diagnosis. Although baseline OCD severity was slightly higher among individuals with OCD+MDD and OCD+GAD (in comparison to those with OCD-only), neither the presence nor the number of pre-treatment comorbid disorders predicated symptom severity, treatment response, remission, or clinically significant change rates at post-treatment. These data suggest that CBT for OCD is robust to the presence of certain common Axis-I comorbidities.
authors.affiliation: Department of Pediatrics, University of South Florida School of Medicine, Rothman Center for Neuropsychiatry, 800 Sixth Street South, St. Petersburg, FL, USA. estorch@health.usf.edu
authors.forename: Eric A
authors.initials: EA
authors.lastname: Storch
authors.forename: Adam B
authors.initials: AB
authors.lastname: Lewin
authors.forename: Lara
authors.initials: L
authors.lastname: Farrell
authors.forename: Mirela A
authors.initials: MA
authors.lastname: Aldea
authors.forename: Jeannette
authors.initials: J
authors.lastname: Reid
authors.forename: Gary R
authors.initials: GR
authors.lastname: Geffken
authors.forename: Tanya K
authors.initials: TK
authors.lastname: Murphy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D015928:Cognitive Behavioral Therapy; D003865:Major Depressive Disorder / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D016584:Panic Disorder / Q000150:complications* / Q000175:diagnosis; D010698:Phobic Disorders / Q000150:complications* / Q000175:diagnosis; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D016896:Treatment Outcome