title: Ion channels at the nucleus: electrophysiology meets the genome.
abstract: The nuclear envelope is increasingly viewed from an electrophysiological perspective by researchers interested in signal transduction pathways that influence gene transcription and other processes in the nucleus. Here, we describe evidence for ion channels and transporters in the nuclear membranes and for possible ion gating by the nuclear pores. We argue that a systems-level understanding of cellular regulation is likely to require the assimilation of nuclear electrophysiology into molecular and biochemical signaling pathways.
authors.affiliation: Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences, Dr. Bohr-Gasse 3, A-1030 Vienna, Austria. antonius.matzke@gmi.oeaw.ac.at
authors.forename: Antonius J M
authors.initials: AJ
authors.lastname: Matzke
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Weiger
authors.forename: Marjori
authors.initials: M
authors.lastname: Matzke
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism*; D004594:Electrophysiology / Q000379:methods*; D018745:Genome, Plant / Q000235:genetics; D007473:Ion Channels / Q000378:metabolism*; D008957:Models, Genetic
chemical_list: D007473:Ion Channels; D002118:Calcium
references.citation: Eukaryot Cell. 2009 Dec;8(12):1814-27
references.pmid: 19801417
references.citation: Biophys J. 1999 Jul;77(1):241-7
references.pmid: 10388753
references.citation: Plant Signal Behav. 2009 Nov;4(11):1024-7
references.pmid: 19829075
references.citation: Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10554-9
references.pmid: 15247428
references.citation: Eur J Neurosci. 2001 Jun;13(12):2314-8
references.pmid: 11454036
references.citation: Nat Rev Mol Cell Biol. 2007 May;8(5):414-20
references.pmid: 17440484
references.citation: Curr Opin Chem Biol. 2008 Apr;12(2):229-37
references.pmid: 18314014
references.citation: J Biol Chem. 2007 Oct 26;282(43):31437-43
references.pmid: 17726020
references.citation: Angew Chem Int Ed Engl. 2007;46(25):4783-5
references.pmid: 17487903
references.citation: Sci Signal. 2008 Dec 09;1(49):re11
references.pmid: 19066400
references.citation: Braz J Med Biol Res. 2009 Jan;42(1):17-20
references.pmid: 18982194
references.citation: FEBS Lett. 1992 May 4;302(1):81-5
references.pmid: 1375170
references.citation: Ann N Y Acad Sci. 1966 Jul 14;137(2):708-16
references.pmid: 5229822
references.citation: Biochem Soc Trans. 2008 Dec;36(Pt 6):1373-7
references.pmid: 19021558
references.citation: Trends Plant Sci. 2008 Sep;13(9):506-14
references.pmid: 18703378
references.citation: J Cell Sci. 2004 Jul 1;117(Pt 15):3087-94
references.pmid: 15226390
references.citation: Trends Plant Sci. 2009 Jun;14(6):295-8
references.pmid: 19447668
references.citation: J Exp Bot. 2007;58(3):361-76
references.pmid: 17150991
references.citation: Curr Opin Plant Biol. 2009 Dec;12(6):752-9
references.pmid: 19875325
references.citation: Mol Biol Cell. 2002 Feb;13(2):425-34
references.pmid: 11854401
references.citation: J Cell Sci. 2009 Dec 1;122(Pt 23):4267-76
references.pmid: 19923270
references.citation: Histochem Cell Biol. 2008 Feb;129(2):105-16
references.pmid: 18228033
references.citation: FEBS J. 2009 Apr;276(7):1800-16
references.pmid: 19243429
references.citation: Trends Cell Biol. 2007 Jun;17(6):261-70
references.pmid: 17498955
references.citation: Nature. 2005 Feb 3;433(7025):527-31
references.pmid: 15616514
references.citation: New Phytol. 2009 Jan;181(2):261-274
references.pmid: 19130634
references.citation: Proteome Sci. 2005 Oct 28;3:8
references.pmid: 16248894
references.citation: Bioessays. 1996 Oct;18(10):849-50
references.pmid: 8967891
references.citation: Cell Calcium. 2006 Nov-Dec;40(5-6):513-25
references.pmid: 17067669
references.citation: Cell. 2006 Apr 7;125(1):187-99
references.pmid: 16615899
references.citation: Trends Plant Sci. 2008 Jan;13(1):20-7
references.pmid: 18155634
references.citation: Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13530-5
references.pmid: 10557355
references.citation: Physiol Plant. 2008 Apr;132(4):399-406
references.pmid: 18333995
references.citation: Plant Methods. 2010 Jan 19;6:2
references.pmid: 20148117
references.citation: FEBS Lett. 2000 Jul 7;476(3):234-9
references.pmid: 10913620
references.citation: Nat Protoc. 2006;1(3):1057-65
references.pmid: 17406387
references.citation: Cell Calcium. 2006 Jan;39(1):65-73
references.pmid: 16289270
references.citation: J Chem Phys. 2009 Oct 21;131(15):155102
references.pmid: 20568885
references.citation: Biochim Biophys Acta. 1998 Oct 15;1375(1-2):117-30
references.pmid: 9767144
references.citation: Plant Cell. 2007 Feb;19(2):610-24
references.pmid: 17307929
references.citation: J Mol Biol. 1999 Apr 9;287(4):741-52
references.pmid: 10191142
references.citation: Immunol Rev. 2009 Sep;231(1):23-44
references.pmid: 19754888
references.citation: J Biol Chem. 2005 Jan 28;280(4):2512-21
references.pmid: 15542857
references.citation: J Biol Chem. 1996 Jan 5;271(1):478-85
references.pmid: 8550605
references.citation: J Proteomics. 2009 Feb 15;72(1):56-70
references.pmid: 18852071
references.citation: Nature. 2009 Oct 15;461(7266):930-9
references.pmid: 19829373
references.citation: PLoS Comput Biol. 2008 Mar 28;4(3):e1000036
references.pmid: 18369427
references.citation: Plant J. 2007 Jan;49(2):208-16
references.pmid: 17173544
references.citation: Plant Cell. 2008 Dec;20(12):3467-79
references.pmid: 19106374
references.citation: Plant Physiol. 2009 Nov;151(3):1197-206
references.pmid: 19700563
references.citation: Dev Cell. 2009 Nov;17(5):626-38
references.pmid: 19922868
references.citation: Science. 2006 Nov 3;314(5800):815-7
references.pmid: 17082456
references.citation: Dev Biol. 1976 Oct 15;53(2):277-84
references.pmid: 1033095
references.citation: Science. 2003 Sep 5;301(5638):1380-2
references.pmid: 12958361
references.citation: Physiol Rev. 2008 Apr;88(2):421-49
references.pmid: 18391169
references.citation: Biophys J. 1990 Aug;58(2):341-55
references.pmid: 2207242
references.citation: J Cell Sci. 2009 Jul 15;122(Pt 14):2337-50
references.pmid: 19571113
references.citation: Mol Plant. 2009 Jan;2(1):13-21
references.pmid: 19529824
references.citation: Can J Physiol Pharmacol. 2006 Mar-Apr;84(3-4):347-65
references.pmid: 16902582
references.citation: Science. 1952 Jan 18;115(2977):58-9
references.pmid: 14913162
references.citation: Nature. 2005 Jun 30;435(7046):1239-43
references.pmid: 15902207
references.citation: J Membr Biol. 2006 Apr;210(3):161-72
references.pmid: 16909338
references.citation: Biophys J. 2007 Aug 15;93(4):1163-74
references.pmid: 17513359
references.citation: Annu Rev Physiol. 2009;71:59-82
references.pmid: 18842100
references.citation: EMBO J. 2009 Sep 2;28(17):2541-53
references.pmid: 19680228
references.citation: Trends Biochem Sci. 2005 Oct;30(10):551-8
references.pmid: 16125387
references.citation: Science. 1995 Dec 15;270(5243):1835-8
references.pmid: 8525380
references.citation: Plant Physiol. 2001 Sep;127(1):10-3
references.pmid: 11553729
references.citation: Annu Rev Plant Biol. 2008;59:519-46
references.pmid: 18444906
references.citation: Curr Opin Plant Biol. 2009 Feb;12(1):87-95
references.pmid: 18938103
references.citation: Plant J. 1999 Sep;19(6):735-47
references.pmid: 10571859
references.citation: Nat Rev Neurosci. 2006 Oct;7(10):761-71
references.pmid: 16988652
references.citation: Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3718-23
references.pmid: 10737809
references.citation: Biochim Biophys Acta. 2009 Jun;1793(6):1096-104
references.pmid: 19250948
references.citation: Cell Calcium. 2006 Apr;39(4):293-303
references.pmid: 16473405
references.citation: Nat Cell Biol. 2003 May;5(5):440-6
references.pmid: 12717445
references.citation: Physiol Rev. 2001 Jan;81(1):1-19
references.pmid: 11152752
references.citation: Front Mol Neurosci. 2009 Jun 22;2:5
references.pmid: 19623246
references.citation: Biochim Biophys Acta. 2006 Nov;1763(11):1209-15
references.pmid: 17052770
references.citation: FASEB J. 2001 Sep;15(11):1895-901
references.pmid: 11532969
references.citation: Bioessays. 1996 Jun;18(6):495-504
references.pmid: 8787537
references.citation: Plant J. 2009 Jul;59(2):243-55
references.pmid: 19392704
references.citation: FEBS Lett. 1990 Oct 1;271(1-2):161-4
references.pmid: 1699797
references.citation: Dev Cell. 2009 Nov;17(5):606-16
references.pmid: 19922866
references.citation: Cell Cycle. 2009 Nov 1;8(21):3527-36
references.pmid: 19823012
references.citation: Prog Biophys Mol Biol. 2007 Sep-Nov;95(1-3):1-15
references.pmid: 17011027
references.citation: News Physiol Sci. 1998 Feb;13:44-50
references.pmid: 11390758
references.citation: Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):359-64
references.pmid: 16407163
references.citation: Nat Rev Mol Cell Biol. 2008 Apr;9(4):323-32
references.pmid: 18354422
references.citation: Cell. 1992 Jun 26;69(7):1133-41
references.pmid: 1617726
references.citation: New Phytol. 2009 Jan;181(2):275-294
references.pmid: 19121028
references.citation: Nature. 1990 Feb 22;343(6260):764-7
references.pmid: 2304551
references.citation: Plant Physiol. 2007 Sep;145(1):192-203
references.pmid: 17631529
references.citation: Can J Physiol Pharmacol. 2009 Feb;87(2):108-19
references.pmid: 19234574
references.citation: J Cell Biochem. 2005 Dec 15;96(6):1185-92
references.pmid: 16211582