Development of novel drugs from marine surface associated microorganisms.
While the oceans cover more than 70% of the Earth's surface, marine derived microbial natural products have been largely unexplored. The marine environment is a habitat for many unique microorganisms, which produce biologically active compounds ("bioactives") to adapt to particular environmental conditions. For example, marine surface associated microorganisms have proven to be a rich source for novel bioactives because of the necessity to evolve allelochemicals capable of protecting the producer from the fierce competition that exists between microorganisms on the surfaces of marine eukaryotes. Chemically driven interactions are also important for the establishment of cross-relationships between microbes and their eukaryotic hosts, in which organisms producing antimicrobial compounds ("antimicrobials"), may protect the host surface against over colonisation in return for a nutrient rich environment. As is the case for bioactive discovery in general, progress in the detection and characterization of marine microbial bioactives has been limited by a number of obstacles, such as unsuitable culture conditions, laborious purification processes, and a lack of de-replication. However many of these limitations are now being overcome due to improved microbial cultivation techniques, microbial (meta-) genomic analysis and novel sensitive analytical tools for structural elucidation. Here we discuss how these technical advances, together with a better understanding of microbial and chemical ecology, will inevitably translate into an increase in the discovery and development of novel drugs from marine microbial sources in the future.
Penesyan
Anahit
A
School of Biotechnology and Biomolecular Sciences and Centre for Marine Bio-Innovation, University of New South Wales, Sydney 2052, Australia.
Kjelleberg
Staffan
S
Egan
Suhelen
S
D001688:Biological Products / Q000302:isolation & purification; D055808:Drug Discovery / Q000379:methods / Q000639:trends; D017753:Ecosystem; D008386:Marine Biology; D012623:Seawater / Q000382:microbiology*; D014871:Water Microbiology
D001688:Biological Products
Appl Environ Microbiol. 2006 Sep;72(9):6079-87
16957232
J Appl Microbiol. 2008 Jun;104(6):1644-58
18298532
Bioresour Technol. 2010 Feb;101(4):1331-6
19818601
J Am Chem Soc. 2008 Feb 13;130(6):1806-7
18205365
Experientia. 1996 Jul 15;52(7):716-22
8698116
Microb Ecol. 1985 Jun;11(2):149-63
24221303
J Chem Inf Comput Sci. 2003 Jan-Feb;43(1):218-27
12546556
Curr Opin Biotechnol. 1997 Dec;8(6):708-12
9425661
Mar Biotechnol (NY). 2002 Sep;4(4):356-66
14961247
J Nat Prod. 2008 Jun;71(6):1095-8
18505284
Lancet Infect Dis. 2005 Feb;5(2):115-9
15680781
IDrugs. 2006 Jun;9(6):420-2
16752312
Curr Opin Microbiol. 2003 Oct;6(5):427-30
14572532
J Antibiot (Tokyo). 1975 Mar;28(3):176-84
1126873
J Org Chem. 2009 Feb 6;74(3):1304-13
19105637
J Antibiot (Tokyo). 2005 Jan;58(1):1-26
15813176
Angew Chem Int Ed Engl. 2009;48(4):660-719
19130444
J Am Chem Soc. 2010 Jan 27;132(3):926-7
20041686
J Nat Prod. 2004 Aug;67(8):1412-4
15332866
Microbiol Res. 2010 May 30;165(4):300-11
19656668
FEMS Microbiol Ecol. 2007 Jan;59(1):81-94
17233746
Chemistry. 2007;13(5):1610-9
17091523
Nat Rev Drug Discov. 2007 Jan;6(1):29-40
17159923
Environ Microbiol. 2002 Aug;4(8):433-42
12153584
Res Microbiol. 2008 Apr;159(3):153-61
18375103
Metab Eng. 2009 Nov;11(6):319-27
19595787
Antonie Van Leeuwenhoek. 2005 Jan;87(1):43-8
15726290
Annu Rev Microbiol. 1985;39:321-46
3904603
Environ Microbiol. 2007 Feb;9(2):521-34
17222150
Org Lett. 2000 Aug 10;2(16):2401-4
10956506
Methods Mol Biol. 2008;431:271-83
18287763
Protein Expr Purif. 2010 Mar;70(1):88-94
19887111
J Antibiot (Tokyo). 1986 Nov;39(11):1623-5
3025147
Chem Biol. 2006 Jan;13(1):31-7
16426969
Arch Microbiol. 2001 Nov;176(5):386-90
11702082
Annu Rev Microbiol. 1990;44:271-301
2252385
Curr Opin Microbiol. 2005 Jun;8(3):276-81
15939350
J Nat Prod. 2004 Dec;67(12):2141-53
15620274
Microbios. 1994;78(314):7-16
8022309
Molecules. 2005 Oct 31;10(10):1286-91
18007521
Science. 2002 May 10;296(5570):1127-9
12004133
Antonie Van Leeuwenhoek. 2005 Jan;87(1):3-9
15726285
Appl Environ Microbiol. 2007 Jan;73(2):622-9
17122394
Microbiol Mol Biol Rev. 2004 Dec;68(4):669-85
15590779
Trends Microbiol. 2007 Nov;15(11):491-9
17997312
Zoolog Sci. 2006 Aug;23(8):669-74
16971784
FEMS Microbiol Ecol. 2001 Mar;35(1):67-73
11248391
Crit Rev Biotechnol. 2002;22(4):315-33
12487423
Appl Environ Microbiol. 2000 Jul;66(7):3113-6
10877816
FEMS Microbiol Ecol. 2009 Jul;69(1):113-24
19453738
Appl Environ Microbiol. 2005 Oct;71(10):6319-24
16204553
J Antibiot (Tokyo). 1993 Apr;46(4):580-8
8501000
FEMS Microbiol Ecol. 2001 May;35(3):305-312
11311441
Environ Microbiol. 2003 Jan;5(1):25-35
12542710
Curr Opin Microbiol. 2008 Jun;11(3):219-25
18524668
Angew Chem Int Ed Engl. 2007;46(25):4704-7
17497617
Curr Opin Biotechnol. 2004 Jun;15(3):199-204
15193327
J Org Chem. 2005 Aug 5;70(16):6196-203
16050677
J Mol Microbiol Biotechnol. 2001 Apr;3(2):301-8
11321587
Microb Ecol. 2008 Jan;55(1):94-106
17497228
Appl Microbiol Biotechnol. 2003 Oct;62(5-6):446-58
12838377
J Nat Prod. 2008 Sep;71(9):1600-3
18702471
Nature. 1996 Nov 7;384(6604 Suppl):11-3
8895593
Biol Bull. 1992 Feb;182(1):105-108
29304709
J Nat Prod. 2007 Jan;70(1):67-74
17253852
J Appl Microbiol. 2003;95(4):814-23
12969296
Environ Microbiol. 2004 Feb;6(2):121-30
14756877
Angew Chem Int Ed Engl. 1999 Mar 1;38(5):643-647
29711552
Proc Natl Acad Sci U S A. 2006 Aug 8;103(32):12115-20
16880384
Rapid Commun Mass Spectrom. 2005;19(24):3643-50
16287035
Chem Biol. 2000 Aug;7(8):593-9
11048950
Drug Discov Today Technol. 2004 Dec;1(3):189-95
24981484
Nat Biotechnol. 2003 Jun;21(6):602
12776140
Antonie Van Leeuwenhoek. 2007 Aug;92(2):155-64
17265101
Angew Chem Int Ed Engl. 2006 Aug 4;45(31):5072-129
16881035
Gene. 2001 Sep 19;275(2):233-40
11587850
Appl Environ Microbiol. 2004 Nov;70(11):6865-70
15528554
J Antibiot (Tokyo). 2002 Jun;55(6):565-70
12195962
PLoS One. 2008 Sep 24;3(9):e3252
18813346
Int J Syst Evol Microbiol. 2005 Sep;55(Pt 5):1759-1766
16166663
Annu Rev Microbiol. 1980;34:209-33
6108090
Anal Chim Acta. 2009 Apr 1;637(1-2):92-100
19286017
Int J Syst Bacteriol. 1998 Oct;48 Pt 4:1205-12
9828422
Science. 1997 May 2;276(5313):734-40
9115194
ISME J. 2007 Nov;1(7):654-9
18043672
Angew Chem Int Ed Engl. 2006 Apr 10;45(16):2609-15
16548033
J Ind Microbiol Biotechnol. 2009 Aug;36(8):1047-56
19471982
Nat Prod Rep. 2005 Dec;22(6):672-95
16311630
Drug Discov Today. 2003 Jun 15;8(12):536-44
12821301
PLoS One. 2008;3(10):e3515
18953415
Curr Opin Biotechnol. 2003 Jun;14(3):303-10
12849784
Environ Microbiol. 2007 Mar;9(3):814-8
17298379
Plasmid. 2007 May;57(3):306-13
17218012
Ernst Schering Res Found Workshop. 2003;(42):167-88
12664541
Science. 2002 May 31;296(5573):1703-6
11988537
Trends Microbiol. 2007 Jun;15(6):279-89
17433686
J Nat Prod. 2007 May;70(5):789-94
17439280
Antonie Van Leeuwenhoek. 2000 Dec;78(3-4):297-305
11386352
Biochem Pharmacol. 2006 Mar 30;71(7):981-90
16290171
Org Lett. 2009 Jan 15;11(2):489-92
19099481
Cancer Res. 1995 Jun 1;55(11):2325-33
7757983
Appl Environ Microbiol. 2007 Apr;73(7):2067-78
17277226
Prog Drug Res. 2008;65:175, 177-210
18084916
Curr Pharm Des. 2002;8(13):1119-35
12052223
Curr Opin Chem Biol. 1999 Aug;3(4):384-7
10419858
Trends Biotechnol. 2009 Jan;27(1):45-52
19022511
Annu Rev Microbiol. 1994;48:559-84
7826019
Science. 1983 Jan 28;219(4583):410-2
17815320
Mol Mar Biol Biotechnol. 1994 Jun;3(3):121-30
7921044
Nat Biotechnol. 2005 Jan;23(1):38-9
15637617
Mem Inst Oswaldo Cruz. 2003 Sep;98(6):843-8
14595466
PLoS One. 2008 Jul 23;3(7):e2744
18648491
Chem Biol. 1998 Oct;5(10):R245-9
9818143
Biochem Pharmacol. 2006 Mar 30;71(7):1006-15
16412984
J Nat Prod. 2009 Apr;72(4):666-70
19245260
Annu Rev Microbiol. 2006;60:255-80
16719716
Nature. 2009 May 14;459(7244):200-6
19444206
Mar Biotechnol (NY). 2008 Sep-Oct;10(5):518-26
18350335
Nat Rev Drug Discov. 2009 Jan;8(1):69-85
19096380
Nature. 1990 May 3;345(6270):63-5
1691827
Appl Environ Microbiol. 2006 May;72(5):3724-32
16672523
Angew Chem Int Ed Engl. 2003 Jan 20;42(3):355-7
12548698
Chembiochem. 2006 Feb;7(2):229-38
16247831
Drug Discov Today. 2004 May 15;9(10):450-8
15109950
Nat Chem Biol. 2006 Dec;2(12):666-73
17108984
J Biotechnol. 2006 Jun 25;124(1):242-57
16414140
Trends Biotechnol. 2005 Sep;23(9):437-40
16038996
J Biotechnol. 2000 Jun 23;80(2):135-42
10908794
Nat Rev Drug Discov. 2005 Mar;4(3):206-20
15729362
Biotechnol Genet Eng Rev. 2000;17:281-323
11255670
J Biotechnol. 1999 Apr 30;70(1-3):27-32
10412203
Mol Microbiol. 2000 Sep;37(5):989-94
10972818
Appl Environ Microbiol. 2004 Mar;70(3):1593-9
15006783
Biochem Pharmacol. 2006 Mar 30;71(7):901-9
16494849
Nature. 2008 Apr 10;452(7188):741-4
18337719
J Nat Prod. 2003 Jul;66(7):1022-37
12880330
Mar Biotechnol (NY). 1999 Jan;1(1):107-111
10373618
Experientia. 1988 Dec 1;44(11-12):1021
3197807
Nat Rev Microbiol. 2003 Oct;1(1):65-70
15040181
Appl Microbiol Biotechnol. 2008 Jul;79(6):1001-8
18461317
Drug Discov Today. 2005 Jan 1;10(1):45-52
15676298
J Antibiot (Tokyo). 2009 Jan;62(1):5-16
19132062
Nat Prod Rep. 2009 Feb;26(2):170-244
19177222
Biotechnol J. 2006 Jul-Aug;1(7-8):815-21
16897828
Org Lett. 2008 Dec 18;10(24):5505-8
19007176
Appl Environ Microbiol. 2005 Oct;71(10):5665-77
16204474
Lett Appl Microbiol. 2008 Nov;47(5):361-6
19146522
Appl Environ Microbiol. 1996 Aug;62(8):2783-8
8702270
ChemMedChem. 2006 Jan;1(1):41-4
16892332
Environ Microbiol. 2005 Aug;7(8):1162-74
16011753
Anal Biochem. 2010 Jan 15;396(2):188-93
19782037