title: Multi-drug resistant E.coli urosepsis in physicians following transrectal ultrasound guided prostate biopsies--three cases including one death.
abstract: Three male physicians underwent transrectal ultrasound guided prostate biopsies for elevated prostate-specific antigen levels or irregular digital rectal exam findings. All three of these patients developed urosepsis secondary to multi-drug resistant organisms despite antibiotic prophylaxis. There are increasing reports of infectious complications following prostate biopsy caused by multi-drug resistant organisms. These cases highlight the potentially lethal risks to healthcare workers who are more likely to harbor multi-drug resistant organisms than the general population. Further research into preoperative assessment and appropriate antibiotic prophylaxis in all potentially high risk patients is warranted.
authors.affiliation: Department of Urology, Dalhousie University, Halifax, Nova Scotia, Canada.
authors.forename: William H
authors.initials: WH
authors.lastname: Carlson
authors.forename: David G
authors.initials: DG
authors.lastname: Bell
authors.forename: Joseph G
authors.initials: JG
authors.lastname: Lawen
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Rendon
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis / Q000009:adverse effects; D016470:Bacteremia / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology; D001707:Biopsy, Needle / Q000009:adverse effects*; D024901:Drug Resistance, Multiple, Bacterial; D004926:Escherichia coli / Q000187:drug effects / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008875:Middle Aged; D010808:Physical Examination; D010820:Physicians; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000032:analysis; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional
chemical_list: D000900:Anti-Bacterial Agents; D017430:Prostate-Specific Antigen