Administration of zonisamide in three cases of dementia with Lewy bodies.
Zonisamide (ZNS) add-on administration was used to treat parkinsonian symptoms in three cases of dementia with Lewy bodies (DLB). ZNS was added after doses of the anti-Parkinson's disease drugs were fixed for at least 4 weeks. A total of 25 mg of ZNS produced mild-moderate improvement of parkinsonian symptoms in two cases, but it did not affect the cognitive functions and behavioral or psychological symptoms. Caregiver burdens were decreased in two cases. Although dizziness and drowsiness were detected, these were improved by decreasing the dose. ZNS may be useful for the treatment of motor symptoms in DLB patients.
Odawara
Toshinari
T
Psychiatric Center, Yokohama City University Medical Center, Yokohama, Japan. odawara@yokohama-cu.ac.jp
Shiozaki
Kazumasa
K
Togo
Takashi
T
Hirayasu
Yoshio
Y
D000368:Aged; D000978:Antiparkinson Agents / Q000008:administration & dosage* / Q000009:adverse effects; D017028:Caregivers / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination / Q000379:methods*; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000008:administration & dosage* / Q000009:adverse effects; D020961:Lewy Body Disease / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000150:complications / Q000188:drug therapy*; D000078305:Zonisamide
D000978:Antiparkinson Agents; D007555:Isoxazoles; D000078305:Zonisamide