title: Malignant pleural mesothelioma in Italy.
abstract: This study reviews a series of 811 malignant pleural mesothelioma cases, diagnosed at hospitals in Trieste and Monfalcone districts of north eastern Italy, a narrow coastal strip with a population of about three lakh, in the period 1968-2008. The diagnosis was based on histological examination in 801 cases, and cytological findings in 10. Necropsy was performed in 610 cases. Occupational histories were obtained directly from the patients or their relatives through personal or telephone interviews. Routine lung sections were examined for asbestos bodies in 500 cases. In 143 cases asbestos bodies were isolated and counted by chemical digestion of the lung tissue using the Smith-Naylor method. The series included 717 men and 94 women aged between 32 and 93 years (mean 69.2 years). Detailed occupational data was obtained for 732 cases.The majority of patients had marine jobs - shipbuilding (449 cases), maritime trades (56 cases), and port activities (39 cases). The nature of work of other patients included a variety of occupations, with non-shipbuilding industries being the most common. Thirty-four women cleaned the work clothes of family members occupationally exposed and hence had a history of asbestos exposure at home. Most of the patients had their first exposure to asbestos before 1960. The latency period ranged between 13 and 73 years (mean 48.2). Latency period among insulators and dock workers were shorter than other categories. Asbestos bodies were detected on routine lung sections in 343 cases (68.6%). Lung asbestos body burdens after isolation ranged between two to 10 millions bodies per gram of dried tissue. Despite some limitations in the use of asbestos in this area since the 1970s, the incidence of tumor remained high during the last years.
authors.affiliation: Center for the Study of Environmental Cancer, Italian League against Cancer, Hospital of Monfalcone, 34074 Monfalcone, Italy.
authors.forename: Claudio
authors.initials: C
authors.lastname: Bianchi
authors.forename: Tommaso
authors.initials: T
authors.lastname: Bianchi
references.citation: Eur J Cancer Prev. 1997 Apr;6(2):162-6
references.pmid: 9237066
references.citation: Occup Med (Lond). 2005 Mar;55(2):79-87
references.pmid: 15757980
references.citation: Br Med J. 1963 Jan 12;1(5323):123
references.pmid: 13981238
references.citation: Ann Occup Hyg. 2008 Jun;52(4):267-79
references.pmid: 18468991
references.citation: Med Lav. 2007 Sep-Oct;98(5):374-80
references.pmid: 17907531
references.citation: Am J Ind Med. 2001 Oct;40(4):363-70
references.pmid: 11598985
references.citation: Ind Health. 2007 Jun;45(3):379-87
references.pmid: 17634686
references.citation: Oncologist. 2007 Oct;12(10):1215-24
references.pmid: 17962615
references.citation: Med Lav. 2005 Nov-Dec;96(6):490-5
references.pmid: 16983974
references.citation: Ind Health. 2001 Apr;39(2):161-7
references.pmid: 11341546
references.citation: Poumon Coeur. 1968;24(5):545-8
references.pmid: 5696355
references.citation: Lung Cancer. 2009 Nov;66(2):191-7
references.pmid: 19232771
references.citation: Lancet. 2007 Mar 10;369(9564):844-849
references.pmid: 17350453
references.citation: Int J Occup Environ Health. 2004 Jan-Mar;10(1):22-5
references.pmid: 15070022
references.citation: J Occup Environ Med. 2007 Apr;49(4):359
references.pmid: 17426518
references.citation: Ind Health. 2000 Jul;38(3):301-8
references.pmid: 10943078
references.citation: Br Med J. 1965 Feb 6;1(5431):350-3
references.pmid: 14237901
references.citation: Ann Occup Hyg. 1968 Oct;11(4):283-93
references.pmid: 5721712
references.citation: Am J Clin Pathol. 1972 Sep;58(3):250-4
references.pmid: 5075106
references.citation: Am J Ind Med. 2000 May;37(5):512-21
references.pmid: 10723045
references.citation: Am J Ind Med. 1993 Aug;24(2):149-60
references.pmid: 8213843
references.citation: Environ Health Perspect. 2008 Dec;116(12):1675-80
references.pmid: 19079719
references.citation: Eur J Cancer. 2007 Dec;43(18):2722-8
references.pmid: 17980576
references.citation: Prev Med. 1977 Sep;6(3):426-42
references.pmid: 333420
references.citation: Histopathology. 2009 Jan;54(1):55-68
references.pmid: 19054156
references.citation: Occup Med (Lond). 2003 May;53(3):209-12
references.pmid: 12724555
references.citation: Minerva Med. 1973 May 9;64(32):1724-7
references.pmid: 4713751
references.citation: Minerva Med. 1972 Jul 7;63(52):2826-33
references.pmid: 4559031
references.citation: Cancer Res. 1980 Nov;40(11):3875-9
references.pmid: 7471040
references.citation: J Toxicol Environ Health B Crit Rev. 2009 Feb;12(2):124-56
references.pmid: 19235622
references.citation: Occup Environ Med. 2009 Mar;66(3):169-74
references.pmid: 18805882
references.citation: Am J Ind Med. 1992;22(4):521-30
references.pmid: 1442787