Two new steroidal alkaloids from the roots of Sarcococca ruscifolia.
Two new steroidal alkaloids, 20alpha-dimethylamino-2alpha-hydroxyl-3beta-tigloylamino-5alpha-pregnane (1) and Delta(16)-20alpha-dimethylamino-3beta,4alpha-diol-5alpha-pregnane (2), along with five known alkaloids, sarcovagine D (3), pachysamine G (4), pachysamine H (5), pachysamine A (6), and terminaline (20S)-20-(N,N-dimethylamino)-5alpha-pregn-3beta,4alpha-diol (7), were isolated from the roots of Sarcococca ruscifolia. Their structures were elucidated on the basis of NMR and MS data, and the relative stereochemistry of 1 was finally determined by X-ray crystallographic analysis.
He
Kang
K
Guiyang College of Traditional Chinese Medicine, Guiyang, China.
Du
Jiang
J
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D031234:Buxaceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D011278:Pregnanes / Q000737:chemistry / Q000302:isolation & purification*; D013237:Stereoisomerism
C549300:20alpha-dimethylamino-2alpha-hydroxyl-3beta-tigloylamino-5alpha-pregnane; D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D011278:Pregnanes; C549299:delta(16)-20alpha-dimethylamino-3beta,4alpha-diol-5alpha-pregnane