Squaramide-catalyzed enantioselective Friedel-Crafts reaction of indoles with imines.
Chiral squaramides are highly enantioselective catalysts for Friedel-Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85-96% yields and 84-96% ees.
Qian
Yong
Y
State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
Ma
Gaoyuan
G
Lv
Aifeng
A
Zhu
Hai-Liang
HL
Zhao
Jing
J
Rawal
Viresh H
VH
D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D007097:Imines / Q000138:chemical synthesis / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D013237:Stereoisomerism
D000577:Amides; D007097:Imines; D007211:Indoles