Diterpenoids from the feces of Trogopterus xanthipes.
Three new isopimarane diterpenoids, trogopteroids A-C (1-3), four new aromatic diterpenoids, trogopteroids D-G (4-7), and 12 known diterpenoids were isolated from the feces of Trogopterus xanthipes. Their structures were identified using spectroscopic methods. The relative configuration of 1 was confirmed by quantum calculations. Compound 1 represents the first example of a norisopimarane diterpenoid with an 8alpha,15alpha-olide ring. With the exception of compound 14, all diterpenoids were evaluated for cytotoxicity against seven human tumor cell lines.
Zhao
Jun
J
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
Zhu
Hua-Jie
HJ
Zhou
Xiao-Jiang
XJ
Yang
Tong-Hua
TH
Wang
Yuan-Yuan
YY
Su
Jia
J
Li
Yan
Y
Cheng
Yong-Xian
YX
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005243:Feces / Q000737:chemistry*; D006801:Humans; D020128:Inhibitory Concentration 50; D012589:Sciuridae / Q000378:metabolism*
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes