title: Iron deficiency in infancy and neurocognitive functioning at 19 years: evidence of long-term deficits in executive function and recognition memory.
abstract: Iron deficiency in infancy negatively impacts a variety of neurodevelopmental processes at the time of nutrient insufficiency, with persistent central nervous system alterations and deficits in behavioral functioning, despite iron therapy. In rodent models, early iron deficiency impairs the hippocampus and the dopamine system. We examined the possibility that young adults who had experienced chronic, severe, iron deficiency as infants would exhibit deficits on neurocognitive tests with documented frontostriatal (Trail Making Test, Intra-/Extra-dimensional Shift, Stockings of Cambridge, Spatial Working Memory, Rapid Visual Information Processing) and hippocampal specificity (Pattern Recognition Memory, Spatial Recognition Memory). Participants with chronic, severe iron deficiency in infancy performed less well on frontostriatal-mediated executive functions, including inhibitory control, set-shifting, and planning. Participants also exhibited impairment on a hippocampus-based recognition memory task. We suggest that these deficits may result from the long-term effects of early iron deficiency on the dopamine system, the hippocampus, and their interaction.
authors.affiliation: Department of Psychology and Social Behavior, University of California, Irvine, California 92697, USA. angela.lukowski@uci.edu
authors.forename: Angela F
authors.initials: AF
authors.lastname: Lukowski
authors.forename: Marlene
authors.initials: M
authors.lastname: Koss
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Burden
authors.forename: John
authors.initials: J
authors.lastname: Jonides
authors.forename: Charles A
authors.initials: CA
authors.lastname: Nelson
authors.forename: Niko
authors.initials: N
authors.lastname: Kaciroti
authors.forename: Elias
authors.initials: E
authors.lastname: Jimenez
authors.forename: Betsy
authors.initials: B
authors.lastname: Lozoff
mesh_terms: D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D001288:Attention / Q000502:physiology; D001928:Brain Diseases, Metabolic / Q000209:etiology*; D002657:Child Development / Q000502:physiology*; D002908:Chronic Disease; D003342:Corpus Striatum / Q000503:physiopathology; D056344:Executive Function / Q000502:physiology*; D005260:Female; D006624:Hippocampus / Q000503:physiopathology; D006801:Humans; D007223:Infant; D007228:Infant Nutrition Disorders / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D007501:Iron / Q000097:blood / Q000627:therapeutic use; D008137:Longitudinal Studies; D008297:Male; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000503:physiopathology; D021641:Recognition, Psychology / Q000502:physiology*; D012720:Severity of Illness Index; D055815:Young Adult
chemical_list: D007501:Iron
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