title: Association between Serotonin-Related Polymorphisms in 5HT2A, TPH1, TPH2 Genes and Bipolar Disorder in Korean Population.
abstract: OBJECTIVE
  The aim of the present study was to examine the association between serotonin-related gene polymorphisms and bipolar disorder in the Korean population. In addition, we sought to explore the relationship between the clinical characteristics of bipolar patients and serotonin-related gene polymorphisms.
  
  
  METHODS
  Inpatients with bipolar disorder (n=103) and control subjects (n=86) were genotyped for 5HT2A 1438A/G, tryptophan hydroxylase 1 (TPH1) 218 A/C, and TPH2 703G/T. We divided patients with bipolar disorder into two groups according to the presence of psychotic symptoms. The severity of their symptoms was measured using the Young Mania Rating Scale (YMRS) and the Brief Psychiatric Rating Scale (BPRS).
  
  
  RESULTS
  There were no significant differences in the genotype distributions or allelic frequencies in the three serotonergic polymorphisms between patients with bipolar disorder and normal controls. There were significant differences in genotype distributions and allele frequencies of the 5-HT2A -1438A/G polymorphism between the psychotic mania group and the non-psychotic mania group (genotype: chi(2)=7.50, p=0.024; allele: chi(2)=5.92, p=0.015). However, after Bonferroni correction this signifact difference disappeared. We did not find significant differences in the genotype distributions or allelic frequencies in the TPH1 218 A/C and TPH2 703G/T polymorphisms between the psychotic mania group and non-psychotic mania group.
  
  
  CONCLUSIONS
  We failed to found the statistically significant association between three polymorphisms and bipolar disorder. However, there was a trend towards association between 5-HT2A -1438A/G polymorphism and psychotic symptom in bipolar disorder. Future research should seek to clarify this association.
authors.affiliation: Department of Psychiatry, College of Medicine, Korea University, Ansan Hospital, Ansan, Korea.
authors.forename: Kwang-Yeon
authors.initials: KY
authors.lastname: Choi
authors.forename: Ho-Kyoung
authors.initials: HK
authors.lastname: Yoon
authors.forename: Yong-Ku
authors.initials: YK
authors.lastname: Kim
references.citation: Bipolar Disord. 2008 Nov;10(7):816-21
references.pmid: 19032713
references.citation: Biochem Pharmacol. 2003 Nov 1;66(9):1673-80
references.pmid: 14563478
references.citation: Biol Psychiatry. 2006 Sep 15;60(6):621-9
references.pmid: 16580642
references.citation: Psychiatr Genet. 2001 Sep;11(3):111-4
references.pmid: 11702051
references.citation: Am J Med Genet. 2002 Jul 8;114(5):533-40
references.pmid: 12116191
references.citation: Psychiatr Genet. 2008 Oct;18(5):240-7
references.pmid: 18797398
references.citation: Science. 2003 Jan 3;299(5603):76
references.pmid: 12511643
references.citation: Arch Gen Psychiatry. 1998 Jul;55(7):593-602
references.pmid: 9672049
references.citation: Biol Psychiatry. 2007 Jan 15;61(2):181-6
references.pmid: 16806105
references.citation: Biol Psychiatry. 2007 Jan 15;61(2):167-73
references.pmid: 16697352
references.citation: Psychopharmacol Bull. 1988;24(1):118-21
references.pmid: 3387515
references.citation: BMC Med Genet. 2005 Mar 31;6:14
references.pmid: 15799788
references.citation: Arch Gen Psychiatry. 2007 May;64(5):543-52
references.pmid: 17485606
references.citation: Biol Psychiatry. 1997 Apr 1;41(7):768-73
references.pmid: 9084895
references.citation: Arch Gen Psychiatry. 2003 May;60(5):497-502
references.pmid: 12742871
references.citation: Psychopharmacology (Berl). 2005 Dec;183(3):378-82
references.pmid: 16240163
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2009 Apr 30;33(3):403-9
references.pmid: 19162119
references.citation: Biol Psychiatry. 2004 Sep 15;56(6):406-10
references.pmid: 15364038
references.citation: Neuropsychopharmacology. 2006 Feb;31(2):431-41
references.pmid: 16123739
references.citation: Br J Psychiatry. 1978 Nov;133:429-35
references.pmid: 728692
references.citation: Biol Psychiatry. 1999 Mar 1;45(5):603-14
references.pmid: 10088047
references.citation: Biol Psychiatry. 2004 Feb 15;55(4):428-33
references.pmid: 14960297
references.citation: Biochem Pharmacol. 1969 May;18(5):1071-81
references.pmid: 5789774
references.citation: Am J Med Genet B Neuropsychiatr Genet. 2004 Aug 15;129B(1):29-33
references.pmid: 15274035
references.citation: Neuroreport. 1998 Apr 20;9(6):1139-41
references.pmid: 9601682
references.citation: Mol Psychiatry. 1998 Jan;3(1):42-9
references.pmid: 9491812
references.citation: Arch Gen Psychiatry. 2007 Sep;64(9):1015-24
references.pmid: 17768266
references.citation: Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jul 1;32(5):1293-7
references.pmid: 18502553
references.citation: Arch Gen Psychiatry. 1998 Jan;55(1):33-7
references.pmid: 9435758
references.citation: Mol Psychiatry. 1998 Jan;3(1):61-6
references.pmid: 9491814