title: IL8 and CXCL13 are potent chemokines for the recruitment of human neural precursor cells across brain endothelial cells.
abstract: It has been recently shown that systemically injected neural precursor cells (NPCs) could cross brain endothelium and favor functional recovery in animal models of multiple sclerosis (MS). Here we show that human NPCs express receptors of the chemokines IL8 and CXCL13 (CXCR1 and CXCR5, respectively) and migrate across brain endothelial cells in vitro, in response to these chemokines. Considering that these chemokines have been found overexpressed in MS in active, but not inactive areas of demyelination, our data suggest that systemically injected human NPCs may be considered for targeting active areas of demyelination in therapeutic approaches of MS.
authors.affiliation: CNRS (UMR8104), Institut Cochin, Université Paris Descartes, Paris, France.
authors.forename: Nicolas
authors.initials: N
authors.lastname: Weiss
authors.forename: Cyrille
authors.initials: C
authors.lastname: Deboux
authors.forename: Nathalie
authors.initials: N
authors.lastname: Chaverot
authors.forename: Florence
authors.initials: F
authors.lastname: Miller
authors.forename: Anne
authors.initials: A
authors.lastname: Baron-Van Evercooren
authors.forename: Pierre-Olivier
authors.initials: PO
authors.lastname: Couraud
authors.forename: Sylvie
authors.initials: S
authors.lastname: Cazaubon
mesh_terms: D001921:Brain / Q000276:immunology* / Q000378:metabolism; D002478:Cells, Cultured; D054382:Chemokine CXCL13 / Q000096:biosynthesis / Q000502:physiology*; D002634:Chemotaxis, Leukocyte / Q000276:immunology*; D053595:Embryonic Stem Cells / Q000276:immunology* / Q000378:metabolism / Q000637:transplantation; D042783:Endothelial Cells / Q000276:immunology* / Q000378:metabolism / Q000637:transplantation; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis / Q000502:physiology*; D009474:Neurons / Q000276:immunology* / Q000378:metabolism / Q000637:transplantation
chemical_list: C110663:CXCL13 protein, human; D054382:Chemokine CXCL13; D016209:Interleukin-8