Different activation of opercular and posterior cingulate cortex (PCC) in patients with complex regional pain syndrome (CRPS I) compared with healthy controls during perception of electrically induced pain: a functional MRI study.
OBJECTIVE
Although the etiology of complex regional pain syndrome type 1 (CRPS 1) is still debated, many arguments favor central maladaptive changes in pain processing as an important causative factor.


METHODS
To look for the suspected alterations, 10 patients with CRPS affecting the left hand were explored with functional magnetic resonance imaging during graded electrical painful stimulation of both hands subsequently and compared with healthy participants.


RESULTS
Activation of the anterior insula, posterior cingulate cortex (PCC), and caudate nucleus was seen in patients during painful stimulation. Compared with controls, CRPS patients had stronger activation of the PCC during painful stimulation of the symptomatic hand. The comparison of insular/opercular activation between controls and patients with CRPS I during painful stimulation showed stronger (posterior) opercular activation in controls than in patients.


CONCLUSIONS
Stronger PCC activation during painful stimulation may be interpreted as a correlate of motor inhibition during painful stimuli different from controls. Also, the decreased opercular activation in CRPS patients shows less sensory-discriminative processing of painful stimuli.These results show that changed cerebral pain processing in CRPS patients is less sensory-discriminative but more motor inhibition during painful stimuli. These changes are not limited to the diseased side but show generalized alterations of cerebral pain processing in chronic pain patients.
Freund
Wolfgang
W
Department of Diagnostic and Interventional Radiology, University Hospitals, Ulm, Germany. freund-ulm@t-online.de
Wunderlich
Arthur P
AP
Stuber
Gregor
G
Mayer
Florian
F
Steffen
Peter
P
Mentzel
Martin
M
Weber
Frank
F
Schmitz
Bernd
B
D000328:Adult; D001703:Biophysics; D001931:Brain Mapping; D004558:Electric Stimulation / Q000009:adverse effects; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006179:Gyrus Cinguli / Q000098:blood supply* / Q000503:physiopathology*; D006225:Hand / Q000294:innervation; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010146:Pain / Q000209:etiology / Q000473:pathology*; D010147:Pain Measurement; D017288:Pain Threshold / Q000502:physiology; D011601:Psychophysics; D012019:Reflex Sympathetic Dystrophy / Q000473:pathology*
D010100:Oxygen