Ion channels at the nucleus: electrophysiology meets the genome.
The nuclear envelope is increasingly viewed from an electrophysiological perspective by researchers interested in signal transduction pathways that influence gene transcription and other processes in the nucleus. Here, we describe evidence for ion channels and transporters in the nuclear membranes and for possible ion gating by the nuclear pores. We argue that a systems-level understanding of cellular regulation is likely to require the assimilation of nuclear electrophysiology into molecular and biochemical signaling pathways.
Matzke
Antonius J M
AJ
Gregor Mendel Institute of Molecular Plant Biology, Austrian Academy of Sciences, Dr. Bohr-Gasse 3, A-1030 Vienna, Austria. antonius.matzke@gmi.oeaw.ac.at
Weiger
Thomas M
TM
Matzke
Marjori
M
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism*; D004594:Electrophysiology / Q000379:methods*; D018745:Genome, Plant / Q000235:genetics; D007473:Ion Channels / Q000378:metabolism*; D008957:Models, Genetic
D007473:Ion Channels; D002118:Calcium
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