[Antisense oligonucleotides as potential drugs for prophylaxis of prion infections].
Prion mRNA translation inhibition by antisense oligodeoxynucleotides (asODN) incorporated into immunoliposomes was investigated. It was shown that asODN complementary to cap region, start-codon region and a part of open reading frame can decrease the prion expression by 80% in L1210 cell line and by 60% in prion-replicating organs of laboratory rats. These results give grounds for further research asODN to be used as a means of prevention and treatment of prion infections.
Stadnyk
V V
VV
Iziumova
L A
LA
Rzhepets'kyĭ
Iu A
IuA
Maĭor
Kh Ia
KhIa
Verbyts'kyĭ
P I
PI
Vlizlo
V V
VV
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D045744:Cell Line, Tumor; D018387:Codon, Initiator / Q000235:genetics; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D007939:Leukemia L1210; D008081:Liposomes; D051379:Mice; D020319:Oligodeoxyribonucleotides, Antisense / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D018621:PrPC Proteins / Q000096:biosynthesis* / Q000235:genetics; D017096:Prion Diseases / Q000517:prevention & control*; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000378:metabolism
D018387:Codon, Initiator; D008081:Liposomes; D020319:Oligodeoxyribonucleotides, Antisense; D018621:PrPC Proteins