Regio- and stereocontrol in rhenium-catalyzed transposition of allylic alcohols.
A hydroxyl group-directed, highly regio- and stereoselective transposition of allylic alcohols based on rhenium catalysis has been developed. The method is suitable for a direct isomerization of acetals into the thermodynamically preferred isomer as long as one of the hydroxyl groups is allylic. This method will expand the scope of rhenium-catalyzed alcohol transpositions for complex molecule synthesis.
Herrmann
Aaron T
AT
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106-9510, USA.
Saito
Tatsuo
T
Stivala
Craig E
CE
Tom
Janine
J
Zakarian
Armen
A
D002384:Catalysis; D020005:Propanols / Q000737:chemistry*; D012211:Rhenium / Q000737:chemistry*; D013237:Stereoisomerism
D020005:Propanols; C006463:allyl alcohol; D012211:Rhenium
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