Bilateral brain regions associated with naming in older adults.
To determine structural brain correlates of naming abilities in older adults, we tested 24 individuals aged 56-79 on two confrontation-naming tests (the Boston Naming Test (BNT) and the Action Naming Test (ANT)), then collected from these individuals structural Magnetic-Resonance Imaging (MRI) and Diffusion Tensor Imaging (DTI) data. Overall, several regions showed that greater gray and white matter volume/integrity measures were associated with better task performance. Left peri-Sylvian language regions and their right-hemisphere counterparts, plus left mid-frontal gyrus correlated with accuracy and/or negatively with response time (RT) on the naming tests. Fractional anisotropy maps derived from DTI showed robust positive correlations with ANT accuracy bilaterally in the temporal lobe and in right middle frontal lobe, as well as negative correlations with BNT RT, bilaterally, in the white matter within middle and inferior temporal lobes. We conclude that those older adults with relatively better naming skills can rely on right-hemisphere peri-Sylvian and mid-frontal regions and pathways, in conjunction with left-hemisphere peri-Sylvian and mid-frontal regions, to achieve their success.
Obler
Loraine K
LK
Boston University School of Medicine, Boston, MA, USA. Loraine.obler@gmail.com
Rykhlevskaia
Elena
E
Schnyer
David
D
Clark-Cotton
Manuella R
MR
Spiro
Avron
A
Hyun
JungMoon
J
Kim
Dae-Shik
DS
Goral
Mira
M
Albert
Martin L
ML
D000368:Aged; D000375:Aging / Q000473:pathology* / Q000502:physiology*; D016880:Anisotropy; D001921:Brain / Q000473:pathology* / Q000502:physiology*; D001931:Brain Mapping; D056324:Diffusion Tensor Imaging; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007802:Language; D007807:Language Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D008606:Mental Processes / Q000502:physiology; D008875:Middle Aged; D009929:Organ Size; D010364:Pattern Recognition, Visual / Q000502:physiology; D011930:Reaction Time; D013060:Speech / Q000502:physiology
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