title: Indoor and outdoor concentrations and determinants of NO2 in a cohort of 1-year-old children in Valencia, Spain.
abstract: Nitrogen dioxide (NO2) is produced from the exhausts of vehicles and gas appliances and is known to pose certain health risks. In this study, we characterize the exposure to this substance during the first year of life, which is an important period of development. To this end, we used passive samplers to measure indoor and outdoor NO2 levels for 2 weeks in the homes of 352 children. To compensate for the fact that NO2 levels were measured only once in each home, a correction factor was calculated to assign each child an outdoor NO2 exposure value for the first year of life. The outdoor NO2 concentrations were 26.1 microg/m(3) while those measured indoors averaged 18.0 microg/m(3). A multivariate linear regression analysis showed that the main determinants of outdoor NO2 levels were the degree of urbanization and the frequency of vehicle traffic at the location of the residence while for indoor NO2 levels the principal determinants were the type of cooking range and water heater present in the home, the season of the year, and both the country of origin and educational level of the mother.
  
  
  CONCLUSIONS
  Exposure to NO2 has been related to respiratory and other health problems among children. Precise identification of the main sources of both indoor and outdoor NO2 should shed light on appropriate intervention periods and methods. Our results indicate that while population density and traffic-related variables are the main determinants of outdoor NO2 levels, the use of gas appliances have the greatest impact on indoor levels. Strategies should thus be developed to reduce such exposure, especially with regard to reducing emissions from vehicle traffic.
authors.affiliation: Centro Superior de Investigaciones en Salud Pública (CSISP), Valencia, Spain. esplugues_ana@gva.es
authors.forename: A
authors.initials: A
authors.lastname: Esplugues
authors.forename: F
authors.initials: F
authors.lastname: Ballester
authors.forename: M
authors.initials: M
authors.lastname: Estarlich
authors.forename: S
authors.initials: S
authors.lastname: Llop
authors.forename: V
authors.initials: V
authors.lastname: Fuentes
authors.forename: E
authors.initials: E
authors.lastname: Mantilla
authors.forename: C
authors.initials: C
authors.lastname: Iñiguez
mesh_terms: D000393:Air Pollutants / Q000032:analysis*; D016902:Air Pollution, Indoor / Q000032:analysis* / Q000517:prevention & control; D002648:Child; D002947:Cities; D015331:Cohort Studies; D003296:Cooking / Q000295:instrumentation / Q000379:methods; D004781:Environmental Exposure / Q000032:analysis* / Q000517:prevention & control; D005260:Female; D006361:Heating / Q000295:instrumentation / Q000379:methods; D006798:Housing; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D009585:Nitrogen Dioxide / Q000032:analysis*; D011156:Population Density; D012044:Regression Analysis; D012621:Seasons; D012907:Smoking; D012931:Social Environment; D012959:Socioeconomic Factors; D013030:Spain; D014505:Urban Population; D001335:Vehicle Emissions / Q000032:analysis* / Q000517:prevention & control
chemical_list: D000393:Air Pollutants; D001335:Vehicle Emissions; D009585:Nitrogen Dioxide