title: APOA5-1131T>C genotype effects on apolipoprotein A5 and triglyceride levels in response to dietary intervention and regular exercise (DIRE) in hypertriglyceridemic subjects.
abstract: OBJECTIVE
  We aimed to determine the influence of apolipoprotein A5 gene (APOA5)-1131T>C single nucleotide polymorphism on the effects of dietary intervention and regular exercise (DIRE) targeting ApoA5 and triglyceride (TG) concentrations.
  
  
  METHODS
  Hypertriglyceridemia patients (TG, 150-500mg/dL, n=283) undertook a 12-week DIRE (replacing 1/3 of refined rice in their diets with legumes, increasing vegetable intake, and regular walking).
  
  
  RESULTS
  Pre-treatment, no genotype-related differences were detected in ApoA5, TG, or HDL cholesterol levels; however, post-treatment, subjects homozygous (T/T) for the T allele had lower serum TG (P=0.009) and higher HDL cholesterol (P=0.036) than other subjects. In T/T subjects, after adjustments for age, sex and weight changes (r1) or initial TG levels (r2), changes in ApoA5 levels negatively correlated with TG changes (r1=-0.29, P=0.05, r2=-0.28, P<0.1) and positively correlated with changes in HDL cholesterol (r1=0.30, P<0.05, r2=0.32, P<0.05) and free fatty acid (r1=0.38, P<0.01, r2=0.40, P<0.01). In those with moderate hypertriglyceridemia (TG, 200-500mg/dL, n=130), APOA5-1131T/T carriers achieved significantly lower TG (P=0.007) and higher HDL cholesterol (P<0.001) than -1131C allele carriers. Additionally, statistically significant interactions between the -1131T>C and the compliance of DIRE were found for the change in TG (P=0.002) and HDL cholesterol (P=0.039). In good compliance group, T/T subjects showed greater reduction of TG and higher increase of HDL cholesterol than other subjects. On the other hand, non-good compliance group had no significant improvement in these variables.
  
  
  CONCLUSIONS
  APOA5-1131T/T carriers may benefit more from the DIRE than C allele carriers. These effects were remarkable in patients with moderate hypertriglyceridemia and the individuals with good compliance.
authors.affiliation: Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Republic of Korea.
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
authors.forename: Jey Sook
authors.initials: JS
authors.lastname: Chae
authors.forename: Oh Yoen
authors.initials: OY
authors.lastname: Kim
authors.forename: Hey Jun
authors.initials: HJ
authors.lastname: Park
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Jean Kyung
authors.initials: JK
authors.lastname: Paik
authors.forename: Sang-Hyun
authors.initials: SH
authors.lastname: Lee
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Lee
mesh_terms: D000328:Adult; D000886:Anthropometry; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000097:blood* / Q000235:genetics*; D002784:Cholesterol / Q000378:metabolism; D008076:Cholesterol, HDL / Q000378:metabolism; D004032:Diet; D015444:Exercise; D005260:Female; D005838:Genotype; D006801:Humans; D015228:Hypertriglyceridemia / Q000178:diet therapy* / Q000235:genetics*; D007723:Korea; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000378:metabolism*
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D008076:Cholesterol, HDL; D014280:Triglycerides; D002784:Cholesterol