Acetaminophen and ibuprofen in the management of fever and mild to moderate pain in children.
Acetaminophen has become the non-narcotic of choice for children because of concerns regarding the connection between acetylsalicylic acid exposure and Reye's syndrome. Ibuprofen, recently granted over-the-counter status for children over two years of age, offers another choice for treatment. The efficacy and safety of both drugs have been studied in numerous clinical trials. This paper reviews the published evidence about the efficacy and safety of acetaminophen and ibuprofen with regard to treating fever and mild to moderate pain in children.
McCullough
H N
HN
Centre for Evaluation of Medicines, St Joesph's Hospital, Hamilton, Ontario in cooperation with the Drug Therapy and Hazardous Substances Committee of the Canadian Paediatric Society.
Pediatrics. 1987 Sep;80(3):315-8
3627881
Pediatrics. 1987 Nov;80(5):743-4
3670978
J Pediatr. 1991 Nov;119(5):803-11
1941390
Clin Pharmacol Ther. 1989 Jul;46(1):9-17
2663318
Neurology. 1997 Jan;48(1):103-7
9008503
Eur J Clin Pharmacol. 1994;46(3):197-201
8070499
Eur J Clin Pharmacol. 1997;51(5):367-71
9049576
Arch Dis Child. 1996 Feb;74(2):164-7
8660083
Ann Emerg Med. 1986 Nov;15(11):1308-13
3777588
Paediatr Anaesth. 1997;7(5):399-403
9308064
Arch Pediatr Adolesc Med. 1995 Jun;149(6):632-7
7767417
J Pediatr. 1991 Nov;119(5):811-4
1941391
Acta Paediatr Jpn. 1997 Apr;39(2):215-7
9141257
Clin Pharmacol Ther. 1992 Aug;52(2):181-9
1505153
Ann Epidemiol. 1997 Oct;7(7):440-5
9349910
Pediatr Infect Dis J. 1996 Feb;15(2):151-6
8822289
Scand J Rheumatol. 1976;5(2):81-3
935827
Pediatrics. 1994 Apr;93(4):693
8134235
JAMA. 1995 Mar 22-29;273(12):929-33
7884951
Br J Clin Pract Suppl. 1990 Aug;70:22-5
2081105
J Pediatr. 1997 Feb;130(2):300-4
9042136
J Pediatr. 1997 Nov;131(5):683-7
9403646
J Pharm Pharmacol. 1997 Apr;49(4):345-76
9232533
J Pediatr. 1998 Jan;132(1):22-7
9469995
Paediatr Anaesth. 1997;7(2):131-7
9188114
Am J Dis Child. 1992 May;146(5):626-32
1621669
Rev Infect Dis. 1991 May-Jun;13(3):462-72
1866550
Am J Dis Child. 1992 May;146(5):622-5
1621668
Anesth Analg. 1995 Sep;81(3):496-500
7653811
Clin Pharmacol Ther. 1993 May;53(5):593-601
8491069
Lancet. 1991 Mar 9;337(8741):591-4
1671951
Can J Anaesth. 1992 Sep;39(7):649-54
1394752
Laryngoscope. 1998 Jan;108(1 Pt 1):97-101
9432075
Otolaryngol Head Neck Surg. 1997 Jul;117(1):76-82
9230328
J Pediatr. 1998 Jan;132(1):5-8
9469992
Eur J Pediatr. 1993 Sep;152(9):747-9
8223808
Clin Pediatr (Phila). 1989 Nov;28(11):525-8
2680215
Am J Emerg Med. 1985 May;3(3):190-2
3873245