Preclinical studied of general toxic properties of preparations containing ultralow doses of antibodies to endogenous regulators.
Preclinical study of the safety of 6 preparations containing ultralow doses of antibodies to endogenous regulators showed that they are relatively safe, are well tolerated by animals in doses more than 1000-fold surpassing the therapeutic dose for humans, and produce no general toxic effect on the organism of laboratory animals.
Karpova
G V
GV
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Tomsk.
Fomina
T I
TI
Vetoshkina
T V
TV
Dubskaya
T Yu
TY
Voronova
O L
OL
Timina
E A
EA
Abramova
E V
EV
Ermolaeva
L A
LA
Perova
A V
AV
D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000633:toxicity*; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D051379:Mice; D011817:Rabbits; D051381:Rats; D018675:Toxicity Tests
D000906:Antibodies; D000911:Antibodies, Monoclonal; C503436:Artrofoon; C534505:IMPAZA; C533336:afala; C547732:anaferon