title: [Value of 18F-FDG-PET/CT in diagnosis of classic fever of unknown origin].
abstract: To evaluate the application of (18)F-FDG PET/CT in diagnosis of classic fever of unknown origin.
  
  
  
  A total of 27 consecutive patients with classic fever of unknown origin (FUO) (19 men, 8 women; aged 24-82 y) underwent (18)F-FDG PET/CT scans. The images were interpreted by visual inspection and semiquantitative analysis(standardized uptake value, SUV). Final diagnosis was based on histopathology or clinical follow-up.
  
  
  
  The cause of FUO was confirmed by followed investigations in 21 of 27 cases after PET/CT scan, including 10 cases of infection, 4 of noninfectious inflammation, 4 of malignancies and 3 of miscellaneous disorders; and remaining 6 cases were still confirmed FUO. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 100.0 %, 83.3%, 83.3%, 100.0% and 96.3%, respectively.
  
  
  
  For patients with fever of unknown origin, (18)F-FDG-PET/CT can be a sensitive, reliable imaging modality. It is suggested that (18)F-FDG-PET/CT should be considered earlier in detecting the causes of FUO, which is difficultly diagnosed by conventional modalities.
authors.affiliation: PET Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
authors.forename: Kui
authors.initials: K
authors.lastname: Zhao
authors.forename: Meng-jie
authors.initials: MJ
authors.lastname: Dong
authors.forename: Ling-xiang
authors.initials: LX
authors.lastname: Ruan
authors.forename: Zhen-feng
authors.initials: ZF
authors.lastname: Liu
authors.forename: Shu-ye
authors.initials: SY
authors.lastname: Yang
authors.forename: Guo-lin
authors.initials: GL
authors.lastname: Wang
authors.forename: Fang
authors.initials: F
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D005335:Fever of Unknown Origin / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18