Frontotemporal dementia or frontotemporal lobar degeneration--overview of a group of proteinopathies.
Frontotemporal dementia is the second most common early onset dementia after Alzheimer disease. Frontotemporal dementias are a complex group of dementias. The clinical diagnosis can be perplexing because of concurring psychiatric and neurologic syndromes. Frontotemporal lobar degeneration, the underlying pathology, represents an emerging group of proteinopathies. Genetic factors play an important part in the etiologies of dementias. This article overviews current defining characteristics of frontotemporal dementias known also as frontotemporal lobar degenerations.
Haberland
Catherine
C
The Chicago Medical School, Rosalind Franklin University, North Chicago, Illinois, USA. chaberland@comcast.net
D000251:Adenosine Triphosphatases / Q000235:genetics / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D002886:Chromosomes, Human, Pair 17; D003937:Diagnosis, Differential; D057180:Frontotemporal Dementia / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D057174:Frontotemporal Lobar Degeneration / Q000175:diagnosis* / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism*; D020774:Pick Disease of the Brain / Q000175:diagnosis; D000077153:Progranulins; D025801:Ubiquitin / Q000235:genetics / Q000378:metabolism; D000074405:Valosin Containing Protein; D016875:tau Proteins / Q000235:genetics / Q000378:metabolism
D018797:Cell Cycle Proteins; C492314:GRN protein, human; D036341:Intercellular Signaling Peptides and Proteins; C054369:MAPT protein, human; D009419:Nerve Tissue Proteins; D000077153:Progranulins; D025801:Ubiquitin; D016875:tau Proteins; D000251:Adenosine Triphosphatases; D000074405:Valosin Containing Protein