title: [Clinicopathological study on the follicular dendritic cell sarcoma].
abstract: OBJECTIVE
  To investigate the clinicopathologic features and differential diagnostic methods for follicular dendritic cell sarcoma.
  
  
  METHODS
  Histological and immunohistochemical examinations and EBER in situ hybridization were used to investigate the pathological features of 5 cases of follicular dendritic cell sarcoma, and related literature was reviewed.
  
  
  RESULTS
  There were 3 males and 2 females with a median age of 54 years (range, 28 - 75 years). The location of lesions included lymph node (2 cases), tonsil (1 case), stomach (1 case), and liver (1 case). The growth patterns were fascicular or whorls and/or diffuse. The neoplastic cells were spindle or ovoid in shape with indistinct border and slightly eosinophilic cytoplasm. The nuclei were round, oval or spindle in shape with small distinct nucleoli. Warthin-Finkeldey-like multinucleated giant cells were detected in two cases. Mitotic figures were found in 1-22/10 HPF. Immunohistochemical staining showed that CD21 and CD23 (3 of 5), CD35 (4 of 5), D2-40 (4 of 4), and CXCL13 (3 of 4) were positive in neoplastic cells. EBER was detected in one of five cases by in situ hybridization. Four cases were followed-up for 6 approximately 25 months and no recurrence or death was observed yet.
  
  
  CONCLUSIONS
  Follicular dendritic cell sarcoma is an extremely rare and should be considered as a moderately malignant tumor, and may present histological polymorphism with certain distinctive features. Immunohistochemistry is necessary in differential diagnosis to distinguish from other tumors.
authors.affiliation: Department of Pathology, Beijing Friendship Hospital, Capital University of Medical Sciences, China.
authors.forename: Shu-hong
authors.initials: SH
authors.lastname: Zhang
authors.forename: Xiao-ge
authors.initials: XG
authors.lastname: Zhou
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Zheng
authors.forename: Yan-ning
authors.initials: YN
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Wang
authors.forename: Jian-lan
authors.initials: JL
authors.lastname: Xie
authors.forename: Yan
authors.initials: Y
authors.lastname: Jin
authors.forename: Xiao-dan
authors.initials: XD
authors.lastname: Zheng
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000378:metabolism; D058846:Antibodies, Monoclonal, Murine-Derived; D054382:Chemokine CXCL13 / Q000378:metabolism; D054740:Dendritic Cell Sarcoma, Follicular / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors / Q000378:metabolism / Q000473:pathology; D006104:Granuloma, Plasma Cell / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D008198:Lymph Nodes / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism; D008875:Middle Aged; D016601:RNA-Binding Proteins / Q000378:metabolism; D017463:Receptors, Complement 3b / Q000378:metabolism; D017464:Receptors, Complement 3d / Q000378:metabolism; D017455:Receptors, IgE / Q000378:metabolism; D012269:Ribosomal Proteins / Q000378:metabolism; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D014067:Tonsillar Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D000098853:Podoplanin
chemical_list: D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D054382:Chemokine CXCL13; D008562:Membrane Glycoproteins; D016601:RNA-Binding Proteins; D017463:Receptors, Complement 3b; D017464:Receptors, Complement 3d; D017455:Receptors, IgE; D012269:Ribosomal Proteins; C110663:CXCL13 protein, human; C117468:PDPN protein, human; D000098853:Podoplanin; C500987:monoclonal antibody D2-40; C067169:RPL22 protein, human