title: [Anti-allergic properties of a novel ethyl 3-(8-fluoro-2-methyl-2,3,4,5-tetrahydropyrido[4,3-b]indol-5-yl)propionate dihydrochloride].
abstract: The influence of ethyl-3-(8-fluoro-2-methyl-2,3,4,5-tetrahydro-1H-gamma-carboline-5-yl)propionate dihydrochloride belonging to the class of gamma-carbolines on the allergic reactions (inflammation and systemic anaphylaxis) has been studied on laboratory animals. It was established that the given substance administered in a dose of 5 - 20 mg/kg exhibits a pronounced antiallergic action. Unlike many other antihistamine drugs, this gamma-carboline derivative probably does not produce sedative effect.
authors.forename: A V
authors.initials: AV
authors.lastname: Ivashchenko
authors.forename: M G
authors.initials: MG
authors.lastname: Kadieva
authors.forename: D V
authors.initials: DV
authors.lastname: Kravchenko
authors.forename: Ia V
authors.initials: IaV
authors.lastname: Lavrovskiĭ
authors.forename: O D
authors.initials: OD
authors.lastname: Mit'kin
authors.forename: R M
authors.initials: RM
authors.lastname: Salimov
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Fedotov
mesh_terms: D000707:Anaphylaxis / Q000188:drug therapy / Q000276:immunology; D000818:Animals; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D002243:Carbolines / Q000627:therapeutic use*; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA
chemical_list: D018926:Anti-Allergic Agents; D002243:Carbolines; D006633:Histamine Antagonists; C549193:ethyl 3-(8-fluoro-2-methyl-2,3,4,5-tetrahydropyrido(4,3-b)indol-5-yl)propionate dihydrochloride