Phospholipase D in brain function and Alzheimer's disease.
Alzheimer's disease is the most common neurodegenerative disorder. Although lipids are major constituents of brain, their role in Alzheimer's disease pathogenesis is poorly understood. Much attention has been given to cholesterol, but growing evidence suggests that other lipids, such as phospholipids, might play an important role in this disorder. In this review, we will summarize the evidence linking phospholipase D, a phosphatidic acid-synthesizing enzyme, to multiple aspects of normal brain function and to Alzheimer's disease. The role of phospholipase D in signaling mechanisms downstream of beta-amyloid as well as in the trafficking and processing of amyloid precursor protein will be emphasized.
Oliveira
Tiago Gil
TG
Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY 10032, USA.
Di Paolo
Gilbert
G
D000544:Alzheimer Disease / Q000201:enzymology / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D009410:Nerve Degeneration / Q000209:etiology / Q000378:metabolism; D010739:Phospholipase D / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D010739:Phospholipase D
Cell Signal. 2008 Oct;20(10):1787-94
18625302
Traffic. 2008 Aug;9(8):1233-9
18422860
Nat Rev Mol Cell Biol. 2007 Feb;8(2):101-12
17245412
Biochim Biophys Acta. 2009 Sep;1791(9):876-80
19376267
Nature. 2006 Oct 12;443(7112):651-7
17035995
J Neurochem. 2009 Aug;110(4):1288-96
19519662
Biochemistry. 1998 Apr 7;37(14):4901-9
9538008
Cell Physiol Biochem. 2005;15(5):211-24
15956784
Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1936-40
16449385
J Biol Chem. 1996 Oct 25;271(43):26482-9
8900116
Proc Natl Acad Sci U S A. 1995 Dec 19;92(26):12151-5
8618862
J Cell Biol. 1997 Aug 11;138(3):495-504
9245781
Neurosci Lett. 2006 Oct 30;407(3):263-7
16973278
FEBS Lett. 1997 Mar 17;405(1):65-7
9094425
Bioorg Med Chem Lett. 2007 Apr 15;17(8):2310-1
17317170
Curr Opin Cell Biol. 2007 Aug;19(4):426-35
17651957
Arch Biochem Biophys. 1993 Nov 1;306(2):486-94
8215453
J Lipid Mediat Cell Signal. 1996 Sep;14(1-3):361-3
8906582
J Neurosci. 2005 Feb 16;25(7):1797-805
15716416
EMBO J. 2004 Feb 11;23(3):483-8
14749724
J Biol Chem. 2003 Jan 31;278(5):3446-54
12435726
Biochim Biophys Acta. 2008 Aug;1781(8):376-82
18573349
Biochim Biophys Acta. 2009 Sep;1791(9):898-904
19341813
Proc Natl Acad Sci U S A. 2006 Dec 19;103(51):19524-9
17158800
J Neurochem. 1987 Apr;48(4):1018-21
3029323
Biochim Biophys Acta. 2009 Sep;1791(9):949-55
19264150
J Biol Chem. 2002 Apr 5;277(14):12334-42
11821392
J Biol Chem. 1987 Dec 25;262(36):17577-83
3121601
J Biol Chem. 2003 Mar 14;278(11):9979-85
12519790
Nat Neurosci. 2003 Apr;6(4):345-51
12658281
Neurochem Res. 2009 Oct;34(10):1838-46
19444607
Brain Res. 1998 Aug 3;800(2):275-81
9685679
Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8286-91
18550814
J Neurochem. 2005 Sep;94(6):1473-87
16042758
Science. 2001 Nov 30;294(5548):1942-5
11729323
Cell Signal. 2006 Dec;18(12):2283-91
16837165
J Biol Chem. 1997 Apr 25;272(17):11408-13
9111050
Biochim Biophys Acta. 2002 May 23;1582(1-3):45-51
12069809
Nat Rev Neurosci. 2007 Sep;8(9):663-72
17684513
J Biol Chem. 1994 Aug 12;269(32):20312-7
8051126
Neurochem Res. 2001 Jul;26(7):771-82
11565608
J Biol Chem. 1947 Apr;168(1):233-40
20291081
Proc Natl Acad Sci U S A. 1993 Jan 15;90(2):567-71
8380642
N Engl J Med. 2010 Jan 28;362(4):329-44
20107219
Neurosci Lett. 1997 Jun 20;229(1):37-40
9224796
J Neurochem. 2004 Feb;88(3):680-8
14720217
J Biol Chem. 1997 Jul 11;272(28):17354-9
9211874
Cell. 2005 Feb 25;120(4):545-55
15734686
J Biol Chem. 2009 May 1;284(18):12145-52
19276086
Nat Neurosci. 2008 Nov;11(11):1311-8
18931664
FEBS Lett. 1995 May 29;365(2-3):125-8
7781763
Neurochem Res. 1993 Mar;18(3):331-4
8386814
Biochem J. 2008 Oct 15;415(2):165-82
18800967
Biochim Biophys Acta. 2009 Sep;1791(9):845-9
19540357
J Cell Biol. 2009 Apr 6;185(1):129-45
19349583
Neurosci Lett. 2001 Nov 27;315(3):159-63
11716987
Mol Biol Cell. 2001 Apr;12(4):943-55
11294898
Cytokine Growth Factor Rev. 2004 Oct;15(5):337-51
15450250
Mol Biol Cell. 2002 Nov;13(11):3930-42
12429836
J Neurochem. 2006 Apr;97(2):365-72
16539674
Biochim Biophys Acta. 2009 Sep;1791(9):889-97
19345277
J Mol Biol. 2004 Apr 2;337(4):1001-9
15033366
Neuron. 2006 Oct 5;52(1):15-31
17015224
Cell Signal. 2008 Dec;20(12):2198-207
18694819
Trends Cell Biol. 2003 Oct;13(10):540-6
14507482
Curr Opin Neurobiol. 2004 Oct;14(5):582-8
15464891
J Biol Chem. 2005 Apr 29;280(17):17294-300
15722360
Neuroscience. 2008 Oct 2;156(2):266-76
18723082
Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11049-53
10500121
Mol Pharmacol. 2009 Mar;75(3):437-46
19064628
Biochem Biophys Res Commun. 1973 Jul 17;53(2):391-8
4736814
Nat Neurosci. 2008 May;11(5):547-54
18391946
J Neurochem. 1995 Oct;65(4):1445-55
7561837
Cell Signal. 2009 Dec;21(12):1784-93
19666113
Science. 2007 May 4;316(5825):750-4
17478722
IUBMB Life. 2006 Aug;58(8):457-61
16916782
Neurochem Res. 1988 Aug;13(8):771-6
3173625
Proc Natl Acad Sci U S A. 1992 Mar 1;89(5):1671-5
1311847
J Biol Chem. 1995 Dec 15;270(50):29640-3
8530346
Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1941-6
16449386
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2915-9
8464907
Proc Natl Acad Sci U S A. 1995 May 23;92(11):4952-6
7761430
Ann Neurol. 1986 Aug;20(2):265-7
3019230
Biochim Biophys Acta. 2006 Aug;1761(8):913-26
16624617
Neurochem Res. 1997 Apr;22(4):523-7
9130265
Curr Biol. 1997 Mar 1;7(3):191-201
9395408
Neuron. 2008 Nov 26;60(4):534-42
19038212
Curr Opin Lipidol. 2009 Jun;20(3):165-70
19369868
Biochem J. 2001 Dec 15;360(Pt 3):707-15
11736663
Alcohol Alcohol. 1995 Jul;30(4):391-406
8540905
Nat Cell Biol. 2006 Nov;8(11):1255-62
17028579
Biochemistry. 2009 Feb 10;48(5):1077-83
19146388
Nat Chem Biol. 2009 Feb;5(2):108-17
19136975
Neurosci Lett. 1997 Jan 24;222(1):5-8
9121721
J Neurosci. 2004 Oct 6;24(40):8752-61
15470141
Acta Histochem. 2010;112(1):81-91
19010519
Mol Cell Biol. 2009 Mar;29(6):1411-20
19114562
J Neurochem. 1987 May;48(5):1597-603
3559569
J Cell Mol Med. 2008 Dec;12(6B):2525-32
19210753
Biochim Biophys Acta. 2009 Sep;1791(9):936-41
19289180
Glia. 2004 Apr 1;46(1):74-83
14999815
Cell Mol Life Sci. 2005 Oct;62(19-20):2305-16
16143829