Prevalence of rheumatologic manifestations of chronic hepatitis C virus infection among Egyptians.
Chronic hepatitis C virus (HCV) viremia has been known to provoke a plethora of autoimmune syndromes referred to as extrahepatic manifestations of chronic HCV infection. Aim of the current study was to assess the prevalence of rheumatologic manifestations among Egyptians with hepatitis C infection and its' association with cryoglobulin profile. The current research represents a cross-sectional study where patients with chronic HCV infection attending the outpatient clinic of the National Hepatology and Tropical Medicine Research Institute over a period of 1 year were interviewed. Patients with decompensated liver disease, on interferon therapy, having end-stage renal disease or coexisting viral infection like hepatitis B surface antibody positive patients were all excluded from the research. Laboratory investigations as well as serological assay including cryoglobulin profile, rheumatoid factor, antinuclear antibody, HCV-PCR were performed. Three hundred and six patients having chronic HCV infection were interviewed in this research. The overall estimated prevalence of rheumatologic manifestations in the current research was 16.39%, chronic fatigue syndrome 9.5%, sicca symptoms 8.8%, arthralgia 6.5%, fibromyalgia 1.9%, myalgia 1.3%, arthritis 0.7%, cryoglobulinemic vasculitis 0.7%, autoimmune hemolytic anemia 0.7%, thrombocytopenia 0.7%. Xerophthalmia was significantly present in male population (p = 0.04), whereas fibromyalgia, cryoglobulinemic vasculitis, arthritis, and autoimmune hemolytic anemia were significantly present in female population under study (p < 0.05). In chronic HCV genotype 4 infection, the prevalence of rheumatologic manifestations was 16.3% with chronic fatigue syndrome and sicca symptoms being the most common with no significant correlation to the degree of elevation of liver disease or viral load.
Mohammed
Reem Hamdy Abdellatif
RH
Department of Rheumatology and Rehabilitation, Faculty of Medicine, Cairo University Hospitals, Cairo, Egypt. rmhamdy@yahoo.com
ElMakhzangy
Hesham Ibrahim
HI
Gamal
Amira
A
Mekky
Fatma
F
El Kassas
Mohammed
M
Mohammed
Nabil
N
Abdel Hamid
Mohammed
M
Esmat
Gamal
G
D000328:Adult; D003430:Cross-Sectional Studies; D003449:Cryoglobulinemia / Q000150:complications / Q000453:epidemiology; D004534:Egypt / Q000453:epidemiology; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000150:complications / Q000453:epidemiology* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012216:Rheumatic Diseases / Q000453:epidemiology* / Q000209:etiology; D055815:Young Adult
Eur J Haematol. 2005 Nov;75(5):417-23
16191092
Reumatismo. 2001;53(1):26-32
12461575
J Virol. 2002 Nov;76(21):11148-54
12368359
Ital J Gastroenterol Hepatol. 1998 Aug;30(4):391-5
9789135
Ann Intern Med. 1995 Oct 15;123(8):615-20
7677303
Semin Arthritis Rheum. 1997 Feb;26(4):689-701
9062950
J Med Virol. 2006 Sep;78(9):1185-9
16847958
J Infect Dis. 2000 Sep;182(3):698-707
10950762
Am J Med. 2004 Jul 1;117(1):10-3
15210382
Med Klin (Munich). 2006 Mar 15;101(3):212-25
16648979
Hepatology. 1995 Mar;21(3):613-9
7533120
J Viral Hepat. 1997 Jan;4(1):9-28
9031061
Br J Rheumatol. 1997 Sep;36(9):981-5
9376995
J Hepatol. 2004 Feb;40(2):341-52
14739110
J Infect Dis. 1990 Aug;162(2):569-70
2115556
Joint Bone Spine. 2006 Dec;73(6):633-8
17056293
Semin Arthritis Rheum. 1998 Oct;28(2):107-13
9806371
World J Gastroenterol. 2007 Dec 28;13(48):6518-28
18161922
Hepatol Res. 2002 Sep;24(1):23
12243789
Gastroenterology. 2003 Dec;125(6):1723-32
14724825
Medicine (Baltimore). 2000 Jan;79(1):47-56
10670409
Rev Med Interne. 2007 Jun;28(6):388-93
17137683
Arthritis Rheum. 1999 Oct;42(10):2204-12
10524695
Dig Liver Dis. 2007 Jan;39(1):2-17
16884964
Ann Intern Med. 1995 Feb 1;122(3):169-73
7810933
Curr Gastroenterol Rep. 2006 Feb;8(1):53-9
16510035
Medicine (Baltimore). 2005 Mar;84(2):81-89
15758837
Clin Exp Rheumatol. 2003 Nov-Dec;21(6 Suppl 32):S89-94
14740433
Clin Exp Immunol. 2002 May;128(2):347-52
11985526
Reumatismo. 2002 Oct-Dec;54(4):316-23
12563365
J Rheumatol. 2009 Jul;36(7):1442-8
19369460
World J Gastroenterol. 2007 May 7;13(17):2467-78
17552031
J Gastrointestin Liver Dis. 2007 Mar;16(1):65-73
17410291
J Hepatol. 1996 Feb;24(2):135-40
8907565
Semin Liver Dis. 2000;20(1):1-16
10895428