title: [Component-based diagnostic approach. Detection of sensitization to lipid transfer proteins in food allergy].
abstract: Sensitization to lipid transfer proteins (LTPs), a pan-allergen in plants, causes severe anaphylactic reactions to foods, especially in the Mediterranean area. A component-based diagnostic approach identified the peach LTP Pru p 3 as a major allergen. We present the case of a 30-year-old LTP-sensitized Spanish woman with a history of severe anaphylactic reaction to grapes, apple and cauliflower in which the detection of specific IgE against the recombinant protein Pru p 3 led to the diagnosis.
authors.affiliation: Klinik für Allergologie und Dermatologie, Universitätsklinikum RWTH Aachen. rbrans@ukaachen.de
authors.forename: R
authors.initials: R
authors.lastname: Brans
authors.forename: H F
authors.initials: HF
authors.lastname: Merk
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000175:diagnosis* / Q000276:immunology* / Q000517:prevention & control; D000918:Antibody Specificity / Q000276:immunology; D052179:Antigens, Plant / Q000276:immunology*; D002352:Carrier Proteins / Q000276:immunology*; D003429:Cross Reactions / Q000276:immunology; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000178:diet therapy / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis* / Q000178:diet therapy / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood*; D010940:Plant Proteins / Q000276:immunology*
chemical_list: D052179:Antigens, Plant; D002352:Carrier Proteins; D010940:Plant Proteins; C511920:lipid transfer proteins, plant; D007073:Immunoglobulin E
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