Comparative host gene transcription by microarray analysis early after infection of the Huh7 cell line by SARS coronavirus and human coronavirus 229E.
During the early stages of infection, SARS-CoV produces more severe perturbation of host cell gene expression in a human epithelial cell line of liver origin than the HCoV-229E.
Tang
B S F
BS
Department of Microbiology, The University of Hong Kong, Queen Mary Hospital Compound, Pokfulam Road, Hong Kong SAR, China. bonetang@hksh.com
Chan
K H
KH
Cheng
V C C
VC
Yuen
K Y
KY
D045744:Cell Line, Tumor; D028941:Coronavirus 229E, Human / Q000378:metabolism; D018352:Coronavirus Infections / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D046228:Microarray Analysis / Q000379:methods; D045473:Severe acute respiratory syndrome-related coronavirus / Q000378:metabolism; D045169:Severe Acute Respiratory Syndrome / Q000378:metabolism*; D014158:Transcription, Genetic