Vasopressin cell groups exhibit strongly divergent responses to copulation and male-male interactions in mice.
Arginine vasopressin (AVP) and its nonmammalian homolog arginine vasotocin influence social behaviors ranging from affiliation to resident-intruder aggression. Although numerous sites of action have been established for these behavioral effects, the involvement of specific AVP cell groups in the brain is poorly understood, and socially elicited Fos responses have not been quantified for many of the AVP cell groups found in rodents. Surprisingly, this includes the AVP population in the posterior part of the medial bed nucleus of the stria terminalis (BSTMP), which has been extensively implicated, albeit indirectly, in various aspects of affiliation and other social behaviors. We examined the Fos responses of eight hypothalamic and three extra-hypothalamic AVP-immunoreactive (-ir) cell groups to copulation, nonaggressive male-male interaction, and aggressive male-male interaction in both dominant and subordinate C57BL/6J mice. The BSTMP cells exhibited a response profile that was unlike all other cell groups: from a control baseline of approximately 5% of AVP-ir neurons colocalizing with Fos, colocalization increased significantly to approximately 12% following nonaggressive male-male interaction, and to approximately 70% following copulation. Aggressive interactions did not increase colocalization beyond the level observed in nonaggressive male mice. These results suggest that BSTMP neurons in mice may increase AVP-Fos colocalization selectively in response to affiliation-related stimuli, similar to findings in finches. In contrast, virtually all other cell groups were responsive to negative aspects of interaction, either through elevated AVP-Fos colocalization in subordinate animals, positive correlations of AVP-Fos colocalization with bites received, and/or negative correlations of AVP-Fos colocalization with dominance. These findings greatly expand what is known of the contributions of specific brain AVP cell groups to social behavior.
Ho
Jacqueline M
JM
Department of Biology, Indiana University, Bloomington, IN 47405, USA. mho@indiana.edu
Murray
John H
JH
Demas
Gregory E
GE
Goodson
James L
JL
D000374:Aggression; D000818:Animals; D001127:Arginine Vasopressin / Q000032:analysis / Q000378:metabolism / Q000502:physiology*; D003307:Copulation / Q000502:physiology*; D004291:Dominance-Subordination; D007031:Hypothalamus / Q000737:chemistry / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000378:metabolism; D012686:Septal Nuclei / Q000737:chemistry / Q000378:metabolism*; D012919:Social Behavior
D016760:Proto-Oncogene Proteins c-fos; D001127:Arginine Vasopressin
J Comp Neurol. 2007 Jun 20;502(6):1109-22
17444499
Horm Behav. 1998 Aug;34(1):67-77
9735230
Peptides. 1989 May-Jun;10(3):615-9
2780420
Horm Behav. 2009 May;55(5):589-96
19446075
Horm Behav. 2005 Jan;47(1):14-21
15579261
Brain Behav Evol. 2007;70(4):274-85
17914259
Physiol Behav. 1996 Apr-May;59(4-5):813-6
8778871
Prog Brain Res. 2008;170:17-27
18655868
J Comp Neurol. 2006 Sep 1;498(1):80-92
16856162
Biol Lett. 2009 Aug 23;5(4):554-6
19493876
Proc Natl Acad Sci U S A. 2009 Nov 10;106(45):19144-9
19858480
Neuroscience. 1986 Nov;19(3):795-802
3796816
Brain Res. 1986 Dec 10;399(2):296-302
3828765
Brain Res. 1997 Jun 20;760(1-2):1-7
9237511
Prog Neurobiol. 2008 Jan;84(1):1-24
18053631
Prog Brain Res. 2008;170:331-6
18655893
Prog Brain Res. 1998;119:3-20
10074777
Horm Behav. 2009 Jun;56(1):101-7
19341739
Proc Natl Acad Sci U S A. 2006 Nov 7;103(45):17013-7
17071744
Neuroscience. 2006;138(3):947-55
16310321
Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):17139-44
18955705
Nat Neurosci. 2004 Oct;7(10):1048-54
15452576
J Comp Neurol. 1990 Mar 15;293(3):476-85
2324325
Neuroscience. 2005;133(3):635-46
15908133
Psychoneuroendocrinology. 2007 Jun;32(5):437-50
17433558
Brain Res. 1984 Apr 23;298(1):141-5
6722551
J Neuroendocrinol. 2000 May;12(5):409-14
10792579
J Comp Neurol. 2007 Feb 20;500(6):1093-105
17183541
Front Neuroendocrinol. 2009 Oct;30(4):429-441
19520105
Nature. 2004 Jun 17;429(6993):754-7
15201909
Eur J Neurosci. 2006 Sep;24(6):1711-20
17004935
Neuroscience. 2010 Feb 3;165(3):819-30
19909796
Gen Comp Endocrinol. 1998 Aug;111(2):233-44
9679095
J Neurosci. 1995 Jun;15(6):4250-8
7790909
Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4870-5
19273843
J Neurosci. 1998 Apr 1;18(7):2667-72
9502824
Brain Res Brain Res Rev. 1998 Dec;28(3):370-490
9858769
Brain Res. 1981 Aug 10;218(1-2):67-78
7023607
Neuropsychopharmacology. 2004 Mar;29(3):483-93
14647484
J Neurosci. 1992 Aug;12(8):2881-7
1494938
Front Neuroendocrinol. 2009 Oct;30(4):442-459
19442683
Physiol Behav. 1990 Nov;48(5):693-9
2082369
Nature. 2000 Feb 17;403(6771):769-72
10693805
Front Neuroendocrinol. 2009 Oct;30(4):497-518
19341763
Horm Behav. 2006 Nov;50(4):506-17
16890230
Front Neuroendocrinol. 2004 Sep-Dec;25(3-4):150-76
15589267
Prog Brain Res. 2008;170:261-76
18655888
J Neurobiol. 1990 Jul;21(5):686-93
2394985
Prog Brain Res. 2008;170:3-15
18655867
J Neurosci. 1997 Jun 1;17(11):4331-40
9151749
Behav Neurosci. 1995 Aug;109(4):782-9
7576222
Neuroscience. 1988 Mar;24(3):937-66
3380308
Proc Biol Sci. 2008 Oct 22;275(1649):2393-402
18628117
Brain Behav Evol. 2000 Feb;55(2):53-76
10838477
Horm Behav. 2009 Jan;55(1):197-202
19013174
Prog Brain Res. 2008;170:65-72
18655872
J Neuroendocrinol. 1999 Jan;11(1):19-25
9918225
Endocrinology. 1989 Nov;125(5):2335-40
2791993
Nat Rev Neurosci. 2006 Feb;7(2):126-36
16429122
J Comp Neurol. 1990 Oct 22;300(4):535-48
2148751
J Neuroendocrinol. 1997 Jul;9(7):487-91
15305566
Physiol Behav. 2008 Sep 3;95(1-2):182-6
18620713
Nature. 1993 Oct 7;365(6446):545-8
8413608
Brain Res. 1994 Jul 11;650(2):212-8
7953686
J Comp Neurol. 1985 Mar 8;233(2):236-54
3882778
J Neuroendocrinol. 1994 Aug;6(4):391-5
7987369
J Neurosci. 1997 Nov 15;17(22):8842-55
9348352
Physiol Behav. 1988;44(2):235-9
2853382
Eur J Neurosci. 2007 Dec;26(12):3597-605
18052969
Neuropharmacology. 2010 Jan;58(1):78-87
19560475
Front Neuroendocrinol. 2004 Sep-Dec;25(3-4):132-49
15589266
Brain Res Brain Res Rev. 2001 Jul;35(3):246-65
11423156
J Neurosci. 1986 Jul;6(7):2085-9
3016215
Neuron. 2005 Aug 18;47(4):503-13
16102534
Brain Res. 1983 Aug 29;273(2):307-17
6311351
Brain Res. 1985 Jan 28;325(1-2):391-4
3978433