[Halogenizing stress and its biomarkers].
Discussed in this review are endogenous mechanisms of formation of reactive halogen-containing compounds (AH) in human body. Primary AH (HOCl and HOBr) are produced through oxidation of Cl- and Br- respectively by hydrogen peroxide catalyzed by myeloperoxidase or oesinophilic peroxidase. Interaction of HOCl and HOBr with functional groups of biologically important molecules give rise to secondary AH. A non-specific reaction of the organism to AH when their synthesis exceeds neutralization or elimination is referred to as halogenizing stress. Reactions of primary and secondary AH with biologically significant molecules (amino acids, proteins, lipids, nucleotides, carbohydrates, vitamins, etc.) are considered and relation of halogenizing stress to oxidative, carbonyl and nitrifying stresses is discussed. Special attention is given to methods for regulation and alleviation of halogenizing stress, detection of its biomarkers, role of AH in the development of certain socially significant diseases (cardiovascular, neurodegenerative, oncological, respiratory, etc.).
Panasenko
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Sergienko
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D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001965:Bromides / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism; D047209:Eosinophil Peroxidase / Q000378:metabolism; D006219:Halogens / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D007454:Iodides / Q000378:metabolism; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000378:metabolism; D013312:Stress, Physiological
D015415:Biomarkers; D001965:Bromides; D002712:Chlorides; D006219:Halogens; D007454:Iodides; D006861:Hydrogen Peroxide; D047209:Eosinophil Peroxidase; D009195:Peroxidase