Functional genomics of endothelial cells treated with anti-angiogenic or angiopreventive drugs.
Angiogenesis is a highly regulated physiological process that has been studied in considerable detail given its importance in several chronic pathologies. Many endogenous factors and hormones intervene in the regulation of angiogensis and classical as well as targeted drugs have been developed for its control. Angiogenesis inhibition has come off the bench and entered into clinical application for cancer therapy, particularly for metastatic disease. While the clinical benefit is currently in terms of months, preclinical data suggest that novel drugs and drug combinations could lead to substantial improvement. The many targets of endogenous angiogenesis inhibitors reflect the complexity of the process; in contrast, current clinical therapies mainly target the vascular endothelial growth factor system. Cancer chemopreventive compounds can retard tumor insurgence and delay or prevent metastasis and many of these molecules hinder angiogenesis, a mechanism that we termed angioprevention. Angiopreventive drugs appear to prevalently act through the inhibition of the pro-inflammatory and anti-apoptotic player NFkappaB, thus contrasting inflammation dependent angiogenesis. Relatively little is known concerning the effects of these angiogenesis inhibitors on gene expression of endothelial cells, the main target of many of these molecules. Here we provide an exhaustive list of anti-angiogenic molecules, and summarize their effects, where known, on the transcriptome and functional genomics of endothelial cells. The regulation of specific genes can be crucial to preventive or therapeutic intervention. Further, novel targets might help to circumvent resistance to anti-angiogenic therapy. The studies we review are relevant not only to cancer but also to other chronic degenerative diseases involving endothelial cells, such as cardiovascular disorders, diabetes, rheumatoid arthritis and retinopaties, as well as vessel aging.
Albini
Adriana
A
MultiMedica Castellanza (VA) and Oncology Research, IRCCS MultiMedica, 20138 Milan, Italy. adriana.albini@multimedica.it
Indraccolo
Stefano
S
Noonan
Douglas M
DM
Pfeffer
Ulrich
U
D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D019008:Drug Resistance, Neoplasm; D042783:Endothelial Cells / Q000187:drug effects* / Q000378:metabolism; D020869:Gene Expression Profiling; D023281:Genomics; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors; D048789:Phytoestrogens / Q000494:pharmacology
D020533:Angiogenesis Inhibitors; D016328:NF-kappa B; D048789:Phytoestrogens
Int J Cancer. 2008 Apr 15;122(8):1730-7
18074350
N Engl J Med. 2006 Oct 5;355(14):1419-31
17021318
J Exp Med. 1995 Jul 1;182(1):155-62
7540647
Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2690-4
7681986
J Biol Chem. 2006 Feb 10;281(6):3604-13
16339148
Clin Cancer Res. 2000 Nov;6(11):4359-64
11106254
Inflamm Bowel Dis. 2008 Jun;14(6):780-93
18200517
Mutat Res. 2005 Dec 11;591(1-2):198-211
16084531
Mol Cell Biol. 1997 Apr;17(4):1938-46
9121441
J Cell Biol. 2002 Aug 5;158(3):529-39
12147676
J Exp Med. 1998 Dec 21;188(12):2349-56
9858521
J Biol Chem. 2004 Jan 23;279(4):2737-46
14576155
Mol Carcinog. 2006 Oct;45(10):752-63
16705744
Int J Oncol. 2003 Jan;22(1):87-91
12469189
Cell. 1997 Jan 24;88(2):277-85
9008168
Blood. 1999 Aug 1;94(3):984-93
10419890
AIDS. 1997 May;11(6):713-21
9143602
Breast Cancer Res. 2005;7(6):R1097-110
16457690
BMB Rep. 2008 Jun 30;41(6):461-5
18593530
Biochem Biophys Res Commun. 2006 Mar 3;341(1):239-44
16413500
J Biol Chem. 2005 Sep 9;280(36):32009-17
16043480
Toxicol Sci. 2002 Jul;68(1):184-99
12075121
J Immunol. 2002 Jun 15;168(12):6090-8
12055219
Am J Pathol. 2004 Jul;165(1):35-52
15215160
Biochem Pharmacol. 2004 Dec 15;68(12):2359-66
15548382
Blood. 1996 May 1;87(9):3877-82
8611715
J Biol Chem. 1998 Jan 16;273(3):1755-63
9430723
Eur J Gynaecol Oncol. 2005;26(5):501-4
16285565
Nat Struct Biol. 2003 Dec;10(12):1039-47
14608375
Int J Oncol. 2005 Nov;27(5):1381-9
16211235
J Interferon Cytokine Res. 2008 Dec;28(12):733-40
18937547
Blood. 2005 Feb 1;105(3):1036-43
15383457
J Biol Chem. 2003 Oct 3;278(40):39251-8
12882979
J Clin Oncol. 2005 Aug 10;23(23):5334-46
15939924
Microvasc Res. 2009 Mar;77(2):71-7
19010336
J Immunol. 2007 Jan 15;178(2):1122-35
17202376
Cancer Res. 2008 Aug 1;68(15):6100-8
18676832
J Exp Med. 1998 Sep 21;188(6):1039-46
9743522
Rejuvenation Res. 2008 Jun;11(3):649-60
18593283
J Biol Chem. 2002 Jun 21;277(25):22175-84
11943782
Cytokine. 2005 Mar 21;29(6):256-69
15749026
Mol Endocrinol. 2007 Jun;21(6):1422-9
17405903
Cancer Res. 2005 Jan 1;65(1):148-56
15665290
J Natl Cancer Inst. 2003 Mar 19;95(6):437-48
12644537
J Biol Chem. 2005 Jan 28;280(4):2405-8
15579907
Int Immunol. 2008 Dec;20(12):1565-73
18940934
Blood. 1999 Mar 1;93(5):1612-21
10029590
Clin Cancer Res. 2005 Jun 15;11(12):4610-9
15958647
FASEB J. 2002 Jan;16(1):2-14
11772931
Cancer Res. 2001 Nov 15;61(22):8171-8
11719447
Biomed Pharmacother. 2008 Nov;62(9):583-9
18295443
Microvasc Res. 2002 Jan;63(1):41-9
11749071
Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3139-46
18065492
Carcinogenesis. 2008 Apr;29(4):779-89
17999991
Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):4082-5
7513432
J Biol Chem. 2004 Jun 18;279(25):26789-96
15087447
Blood. 1996 May 15;87(10):4286-95
8639787
Endocrinology. 2003 Apr;144(4):1574-84
12639942
Cancer Res. 2006 Feb 15;66(4):2488-94
16489057
Cancer Lett. 2002 Aug 8;182(1):43-51
12175522
Carcinogenesis. 1996 Feb;17(2):271-5
8625449
Br J Nutr. 2007 Apr;97(4):692-8
17349082
Cancer Lett. 2001 Sep 28;171(1):11-6
11485823
Cancer Res. 2003 Sep 15;63(18):5926-39
14522919
J Mammary Gland Biol Neoplasia. 2003 Jul;8(3):269-85
14973373
Science. 1997 Jul 4;277(5322):55-60
9204896
Endocrinology. 2002 Aug;143(8):3114-21
12130577
J Med Chem. 2003 Mar 27;46(7):1116-9
12646019
Eur Cytokine Netw. 2009 Jun;20(2):81-7
19541594
Nat Genet. 2003 Jan;33(1):49-54
12469122
J Transl Med. 2009 Jan 14;7:5
19144161
Endocrinology. 1996 Sep;137(9):3729-37
8756539
J Hepatol. 2009 Oct;51(4):725-33
19665249
Leukemia. 2006 Apr;20(4):583-9
16467866
Nature. 1982 May 27;297(5864):307-12
6176876
Cell Physiol Biochem. 2007;19(1-4):137-52
17310108
Mol Nutr Food Res. 2005 Aug;49(8):763-71
15937998
Blood. 2005 Feb 15;105(4):1660-8
15479729
Cancer Res. 2001 Jul 1;61(13):5090-101
11431346
Int J Cancer. 1998 Oct 29;78(3):361-5
9766572
Eur J Immunol. 2009 Oct;39(10):2789-99
19637227
Breast Cancer Res Treat. 2008 Jul;110(1):85-98
17687646
Biochem Biophys Res Commun. 2003 Oct 24;310(3):804-10
14550275
Nat Biotechnol. 2007 Aug;25(8):911-20
17664940
Cancer Res. 2005 Apr 1;65(7):2906-13
15805293
Nature. 1994 Mar 17;368(6468):237-9
7511798
J Biol Chem. 2006 Nov 24;281(47):35764-9
16998237
Cancer Res. 2008 Mar 15;68(6):1843-50
18339865
Clin Cancer Res. 2008 Sep 15;14(18):5893-9
18794102
Am J Pathol. 1999 Apr;154(4):1211-22
10233859
FASEB J. 2002 Feb;16(2):267-9
11772950
Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):178-83
11773625
Pharmacology. 2004 May;71(1):1-9
15051917
Neoplasia. 2004 Jul-Aug;6(4):354-63
15256057
Mol Nutr Food Res. 2009 Jun;53(6):686-98
19437480
FASEB J. 2006 Mar;20(3):527-9
16403733
J Nutr Biochem. 2006 Mar;17(3):157-64
16169203
Mol Cancer Ther. 2008 Mar;7(3):464-73
18347134
Int J Cancer. 1983 May 15;31(5):649-53
6189790
J Biol Chem. 2001 Aug 24;276(34):31959-68
11399763
Ann N Y Acad Sci. 2003 May;993:351-61; discussion 387-93
12853328
Cancer Metastasis Rev. 2008 Mar;27(1):75-83
18046511
J Clin Biochem Nutr. 2009 May;44(3):223-30
19430610
Int J Oncol. 2003 Apr;22(4):741-50
12632063
Endocrinology. 2007 May;148(5):2317-25
17255201
Int J Oncol. 2002 Aug;21(2):379-83
12118335
Mol Med. 1998 Jun;4(6):376-83
10780880
Cancer Res. 2005 Sep 15;65(18):8359-65
16166313
EMBO J. 2003 Aug 15;22(16):4237-48
12912921
Eur J Cancer. 2009 May;45(8):1474-84
19223175
Regul Pept. 2006 Jul 15;135(1-2):78-84
16725215
Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1246-51
9990009
Biochem Biophys Res Commun. 2006 Jun 16;344(4):1284-9
16650813
Br J Cancer. 2000 Sep;83(6):811-6
10952787
J Surg Res. 2007 Apr;138(2):163-9
17257620
Cancer Res. 2004 Sep 15;64(18):6482-8
15374958
Cancer Res. 2002 Jul 15;62(14):4123-31
12124351
Cytokine. 2005 Jun 21;30(6):366-77
15869882
Biomaterials. 2004 Oct;25(23):5333-46
15130718
Mol Cancer Ther. 2004 Sep;3(9):1091-9
15367703
Clin Cancer Res. 2005 Aug 1;11(15):5595-602
16061878
Mol Pharmacol. 2004 Jan;65(1):99-110
14722241
Apoptosis. 2009 Mar;14(3):298-308
19153832
Arterioscler Thromb Vasc Biol. 1999 Sep;19(9):2041-8
10479644
Proc Natl Acad Sci U S A. 2001 Jun 5;98(12):6656-61
11381144
Am J Pathol. 1997 Nov;151(5):1225-9
9358747
J Biol Chem. 2008 Jan 25;283(4):2231-45
18032389
Lancet. 1997 Oct 11;350(9084):1047-59
10213546
Mol Cell Biol. 2003 Aug;23(15):5401-8
12861025
Nat Rev Cancer. 2008 Aug;8(8):592-603
18650835
Cancer Chemother Pharmacol. 1991;28(4):255-8
1879042
J Neuroimmunol. 2003 Jun;139(1-2):109-18
12799028
Cancer Res. 2006 May 1;66(9):4816-25
16651437
Annu Rev Immunol. 2005;23:337-66
15771574
Physiol Genomics. 2008 Apr 22;33(2):278-91
18303084
J Nutr. 2006 Oct;136(10):2512-8
16988119
Am J Physiol Cell Physiol. 2003 Jun;284(6):C1577-83
12734110
Proc Natl Acad Sci U S A. 2009 Jul 28;106(30):12542-7
19620711
Am J Pathol. 2006 Nov;169(5):1875-85
17071608
Microvasc Res. 2003 May;65(3):186-90
12711260
J Med Chem. 2008 Mar 27;51(6):1546-59
18311895
Nat Med. 2002 Feb;8(2):128-35
11821896
Nat Med. 1999 Nov;5(11):1216
10545959
Mol Med. 2004 Jan-Jun;10(1-6):19-27
15502879
Biochem Pharmacol. 2005 Jan 15;69(2):307-18
15627483
Endocrinology. 1996 Oct;137(10):4511-3
8828515
Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4766-71
12682293
J Mol Biol. 2002 May 10;318(4):1009-17
12054798
J Clin Invest. 2004 Oct;114(7):898-907
15467828
J Pharmacol Exp Ther. 2005 Nov;315(2):805-11
16046615
J Thromb Haemost. 2009 May;7(5):803-10
19320820
Nucleic Acids Res. 2009 Jan;37(Database issue):D852-7
18996892
Br J Nutr. 2009 Jan;101(2):169-81
18761777
Cancer Res. 2002 Oct 1;62(19):5580-9
12359771
J Nutr. 2002 Dec;132(12):3623-31
12468598
Am J Pathol. 2002 Nov;161(5):1749-59
12414522
Food Chem Toxicol. 2008 Aug;46(8):2616-28
18539377
Mol Aspects Med. 2007 Feb;28(1):59-86
17306360
Cancer Res. 2009 Jun 1;69(11):4716-23
19435899
Int J Oncol. 2004 Feb;24(2):399-407
14719117
Am J Nephrol. 1999;19(1):21-7
10085445
Clin Cancer Res. 2002 Jul;8(7):2413-22
12114447
J Biol Chem. 2002 Jul 26;277(30):27367-77
12021267
Cancer Res. 2000 Aug 15;60(16):4561-72
10969808
Hum Gene Ther. 2003 Jun 10;14(9):883-95
12828859
Cancer Gene Ther. 2008 Feb;15(2):101-7
18197164
Biotechnol Appl Biochem. 2006 Jul;45(Pt 1):29-36
16640504
Science. 1990 Jan 5;247(4938):77-9
1688470
J Immunol. 2004 Apr 1;172(7):4111-22
15034023
Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9049-53
1409601
Int J Cancer. 2006 Apr 1;118(7):1805-13
16217760
Cancer Res. 2009 Jul 15;69(14):5893-900
19567671
Toxicol Sci. 2006 May;91(1):93-103
16443925
FASEB J. 1999 Dec;13(15):2195-202
10593867
Proc Natl Acad Sci U S A. 1990 Sep;87(17):6624-8
1697685
Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10705-9
8248162
Cancer. 2001 Feb 15;91(4):822-32
11241252
Int J Cancer. 2005 Dec 10;117(5):775-80
15981212
J Biomed Sci. 2001 Mar-Apr;8(2):214-22
11287753
Curr Eye Res. 2007 Sep;32(9):801-12
17882713
Nat Rev Cancer. 2007 Feb;7(2):139-47
17218951
Biochem Pharmacol. 1998 Mar 15;55(6):775-83
9586949
Int J Cancer. 2002 Jun 20;99(6):846-52
12115487
J Invest Dermatol. 2007 Jan;127(1):65-74
16888632
Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4736-41
12682294
Mol Carcinog. 2004 Oct;41(2):108-119
15378649
Pancreas. 2004 Aug;29(2):93-8
15257099
Endocrinology. 2003 Nov;144(11):4955-66
12960074
Int Immunopharmacol. 2008 Nov;8(11):1493-502
18573352
J Biol Chem. 2008 Jan 25;283(4):2335-43
18024432
Cancer Res. 2004 Feb 1;64(3):1122-9
14871847
Arthritis Rheum. 2009 Jun;60(6):1743-52
19479826
J Nutr. 2005 Dec;135(12 Suppl):2978S-2986S
16317158
Biochem Biophys Res Commun. 1988 Aug 30;155(1):429-35
3137936
J Natl Cancer Inst. 2003 Jun 4;95(11):829
12783940
Mol Cancer Ther. 2008 Jun;7(6):1604-14
18566231
Proc Natl Acad Sci U S A. 1990 Sep;87(17):6487-91
1697682
Cell. 1998 Feb 6;92(3):391-400
9476898
J Biol Chem. 2000 Jan 14;275(2):1209-15
10625665
Thromb Haemost. 2006 Apr;95(4):668-77
16601838
Drugs Today (Barc). 2005 Dec;41(12):773-84
16474853
Gene Ther. 2002 Jul;9(13):867-78
12080381
Eur Cytokine Netw. 2009 Dec;20(4):225-34
20167562
J Biol Chem. 2002 Jun 7;277(23):20453-60
11923291
Cancer Res. 1987 Oct 1;47(19):5155-61
2441862
Cancer Cell. 2005 Oct;8(4):299-309
16226705
Planta Med. 2005 Nov;71(11):999-1004
16320199
Neuroimmunomodulation. 2007;14(1):46-56
17700040
Cancer Res. 2005 Dec 1;65(23):10637-41
16322203
Nature. 1990 Dec 6;348(6301):555-7
1701033
J Biol Chem. 1999 Oct 8;274(41):29568-71
10506224
Neurology. 2009 Apr 7;72(14):1217-22
19349600
Clin Exp Immunol. 2006 Sep;145(3):535-44
16907924
Mol Ther. 2005 Jul;12(1):144-52
15963930
Food Chem Toxicol. 2004 Mar;42(3):445-52
14871586
Pharmacogenomics J. 2006 Jul-Aug;6(4):269-78
16432535
Biochem Biophys Res Commun. 2007 Apr 27;356(1):193-9
17349616
Nature. 2007 Dec 6;450(7171):825-31
18064003
Anticancer Drug Des. 2001 Aug-Oct;16(4-5):209-15
12049479
Reproduction. 2007 Jul;134(1):123-35
17641094
Int J Mol Med. 2007 Nov;20(5):689-97
17912462
J Natl Cancer Inst. 1990 May 16;82(10):848-53
1692094
Endocrinology. 1977 Oct;101(4):1104-10
561688
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2645-50
10077564
J Biol Chem. 2003 Feb 7;278(6):4238-49
12435733
Endocrinology. 2000 Nov;141(11):4278-83
11089563
Cell. 1994 Oct 21;79(2):315-28
7525077
J Biol Chem. 1991 Dec 5;266(34):22939-47
1744087
Nutr Cancer. 2007;58(2):239-46
17640171
Cell. 1989 Feb 10;56(3):345-55
2464438
Pharmacogenet Genomics. 2005 Nov;15(11):817-29
16220113
Proc Natl Acad Sci U S A. 2004 May 25;101(21):8005-10
15148373
J Immunol. 2002 Mar 15;168(6):2644-51
11884428
Science. 1999 Sep 17;285(5435):1926-8
10489375
Invest Ophthalmol Vis Sci. 1999 Aug;40(9):2158-62
10440274
J Natl Cancer Inst. 1995 Apr 19;87(8):581-6
7538593
Physiol Genomics. 2006 Oct 3;27(1):20-8
17018690
J Natl Cancer Inst. 1989 Apr 5;81(7):497-502
2921774
Mol Nutr Food Res. 2009 Jul;53(7):859-68
19496084
Mol Cancer Ther. 2008 Jul;7(7):1789-96
18644991
Genome Res. 2004 Aug;14(8):1585-93
15289477
Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):14138-43
9391166
Clin Cancer Res. 2004 Jul 15;10(14):4865-73
15269163
Carcinogenesis. 2007 May;28(5):1008-20
17127716
Cell Transplant. 2009;18(4):459-69
19622233
Am J Pathol. 2000 Apr;156(4):1381-93
10751362
Anticancer Res. 2006 Mar-Apr;26(2A):1281-8
16619535
Cancer Res. 2006 Dec 1;66(23):11207-13
17145865
Pharm Res. 2005 Nov;22(11):1805-20
16132347
Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):596-604
15767336
Oncogene. 2005 Feb 10;24(7):1188-202
15558015
Br J Nutr. 2008 Apr;99(4):715-22
17916277
J Cell Biochem. 2005 Oct 1;96(2):242-61
16094651
Curr Pharm Des. 2008;14(3):221-5
18220832
Autoimmunity. 2003 Dec;36(8):481-90
14984025
Microvasc Res. 2006 May;71(3):152-62
16650878
Carcinogenesis. 2009 May;30(5):851-60
19237608
Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6374-8
7541539
J Biol Chem. 2000 Mar 17;275(11):8051-61
10713126
Nutr Metab Cardiovasc Dis. 2006 Jan;16(1):35-43
16399490
Cancer Res. 2007 May 15;67(10):4878-85
17510417
Mol Cell Biochem. 2009 May;325(1-2):121-30
19191009
Biochem Biophys Res Commun. 1995 May 5;210(1):51-7
7537965
Mol Cell Endocrinol. 2008 Dec 16;296(1-2):41-52
18951951
Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):13791-6
8943014
Mol Cancer Res. 2005 Apr;3(4):203-18
15831674
N Engl J Med. 2002 Dec 19;347(25):1999-2009
12490681
Curr Pharm Des. 2007;13(20):2025-44
17627537
Immunity. 1998 Jul;9(1):25-34
9697833
Hum Gene Ther. 2005 Aug;16(8):957-70
16076254
J Cell Biol. 1990 Aug;111(2):765-72
1696271
N Engl J Med. 2004 Dec 30;351(27):2805-16
15625332
J Transl Med. 2008 Aug 09;6:44
18691426
Endocrinology. 2006 Dec;147(12):5740-51
16959845
Biosci Biotechnol Biochem. 2009 Mar 23;73(3):722-5
19270413
Cancer Res. 1994 Apr 1;54(7 Suppl):2032s-2037s
8137334
Nat Rev Cancer. 2002 Jul;2(7):537-43
12094240
Nat Med. 2005 Sep;11(9):992-7
16127434
J Natl Cancer Inst. 2003 Mar 5;95(5):350-1
12618498
Gene Ther. 2004 Feb;11(3):284-91
14737088
Cancer Biol Ther. 2007 Dec;6(12):1938-43
18059161
Clin Cancer Res. 2006 Feb 15;12(4):1088-96
16489061
World J Surg. 2009 Apr;33(4):630-7
19137362
Int J Urol. 2009 Mar;16(3):323-8
19207613
J Biol Chem. 2001 Mar 30;276(13):10229-33
11150311
Prostate. 2002 Jul 1;52(2):139-49
12111705
Nat Rev Drug Discov. 2004 May;3(5):391-400
15136787
Cold Spring Harb Symp Quant Biol. 2002;67:255-66
12858548
Cancer Res. 2006 May 15;66(10):5047-55
16707426
Cancer Res. 1999 Feb 15;59(4):886-94
10029080
Cancer Res. 1999 Dec 1;59(23):5875-7
10606226
Cancer Res. 2006 May 15;66(10):5322-9
16707458
Gene Ther. 2006 Jun;13(12):953-65
16511522
Cancer Res. 2007 Dec 15;67(24):12007-17
18089832
Proc Natl Acad Sci U S A. 2009 Jan 6;106(1):250-5
19104057
Cell. 2007 Nov 2;131(3):463-75
17981115
Cancer Lett. 2002 Dec 5;186(2):157-64
12213285
J Nutr. 2006 Mar;136(3):704-8
16484547
Cancer Res. 2008 Apr 15;68(8):2920-6
18413761
Nature. 2002 Aug 22;418(6900):823
12192390
Anticancer Res. 2005 Sep-Oct;25(5):3293-302
16101141
Blood. 2004 Feb 15;103(4):1185-91
14563633
BMC Med Genomics. 2008 Oct 10;1:49
18847459
Curr Pharm Des. 2009;15(30):3577-89
19860702
Science. 1999 Jul 9;285(5425):245-8
10398599
Neoplasia. 2009 Oct;11(10):1106-15
19794969
Inflamm Res. 2004 Aug;53(8):377-89
15316669
Biochim Biophys Acta. 2003 Jul 14;1638(2):187-96
12853125
EMBO J. 2003 Aug 1;22(15):3772-82
12881412
Endothelium. 2008 Jan-Feb;15(1):73-84
18568947
Science. 1990 Jun 15;248(4961):1408-10
1694043
J Clin Invest. 2005 Oct;115(10):2801-10
16151532
Int J Cancer. 2003 Mar 20;104(2):204-12
12569576
Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):620-4
11209058
J Cell Biochem. 2007 Aug 15;101(6):1492-504
17295210
Endothelium. 2006 Jul-Aug;13(4):249-66
16990182
J Natl Cancer Inst. 1995 Apr 19;87(8):557-9
7538592