APOA5-1131T>C genotype effects on apolipoprotein A5 and triglyceride levels in response to dietary intervention and regular exercise (DIRE) in hypertriglyceridemic subjects.
OBJECTIVE
We aimed to determine the influence of apolipoprotein A5 gene (APOA5)-1131T>C single nucleotide polymorphism on the effects of dietary intervention and regular exercise (DIRE) targeting ApoA5 and triglyceride (TG) concentrations.


METHODS
Hypertriglyceridemia patients (TG, 150-500mg/dL, n=283) undertook a 12-week DIRE (replacing 1/3 of refined rice in their diets with legumes, increasing vegetable intake, and regular walking).


RESULTS
Pre-treatment, no genotype-related differences were detected in ApoA5, TG, or HDL cholesterol levels; however, post-treatment, subjects homozygous (T/T) for the T allele had lower serum TG (P=0.009) and higher HDL cholesterol (P=0.036) than other subjects. In T/T subjects, after adjustments for age, sex and weight changes (r1) or initial TG levels (r2), changes in ApoA5 levels negatively correlated with TG changes (r1=-0.29, P=0.05, r2=-0.28, P<0.1) and positively correlated with changes in HDL cholesterol (r1=0.30, P<0.05, r2=0.32, P<0.05) and free fatty acid (r1=0.38, P<0.01, r2=0.40, P<0.01). In those with moderate hypertriglyceridemia (TG, 200-500mg/dL, n=130), APOA5-1131T/T carriers achieved significantly lower TG (P=0.007) and higher HDL cholesterol (P<0.001) than -1131C allele carriers. Additionally, statistically significant interactions between the -1131T>C and the compliance of DIRE were found for the change in TG (P=0.002) and HDL cholesterol (P=0.039). In good compliance group, T/T subjects showed greater reduction of TG and higher increase of HDL cholesterol than other subjects. On the other hand, non-good compliance group had no significant improvement in these variables.


CONCLUSIONS
APOA5-1131T/T carriers may benefit more from the DIRE than C allele carriers. These effects were remarkable in patients with moderate hypertriglyceridemia and the individuals with good compliance.
Jang
Yangsoo
Y
Yonsei University Research Institute of Science for Aging, Yonsei University, Seoul, Republic of Korea.
Chae
Jey Sook
JS
Kim
Oh Yoen
OY
Park
Hey Jun
HJ
Kim
Ji Young
JY
Paik
Jean Kyung
JK
Lee
Sang-Hyun
SH
Lee
Jong Ho
JH
D000328:Adult; D000886:Anthropometry; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000097:blood* / Q000235:genetics*; D002784:Cholesterol / Q000378:metabolism; D008076:Cholesterol, HDL / Q000378:metabolism; D004032:Diet; D015444:Exercise; D005260:Female; D005838:Genotype; D006801:Humans; D015228:Hypertriglyceridemia / Q000178:diet therapy* / Q000235:genetics*; D007723:Korea; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000378:metabolism*
C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D008076:Cholesterol, HDL; D014280:Triglycerides; D002784:Cholesterol