title: [Prepubertal-type vulva fibroma: a clinicopathological study of two cases].
abstract: OBJECTIVE
  To study the clinicopathological features, immnophenotype and differential diagnosis of prepubertal-type vulva fibroma (PVF).
  
  
  METHODS
  Clinical, radiological and pathological features of 2 cases of PVF were analyzed along with a literature review.
  
  
  RESULTS
  Both patients were females of 8.5 and 54 years of age, presented with recurrent unilateral mass at the labium major respectively. Grossly, cut surface of the tumor appeared as the gray fibrous tissue without any definited lump detected. Histologically, the ill-circumscribed lesion located predominantly in the deep dermis with an extension into the subcutaneous tissue. They had a low cell density consisting of scattered spindle shaped fibroblast-like cells and a large amount of collagen fiber matrix, nuclear atypia not seen and mitotic figures scanty. The tumor cells extended downward under the epithelium and infiltrated between the fat tissue, nerve fibers as well as the capillaries making a lesion looked somewhat like a harmatoma. Immunohistochemically, the spindle cells were uniformly positive for vimentin, weakly positive for CD34, and negative for alpha-smooth muscle actin (SMA), muscle specific actin (HHF35), desmin, h-caldesmon, CD99, S-100 protein, bcl-2, beta-catenin, estrogen and progesterone receptors.
  
  
  CONCLUSIONS
  PVF is a benign mesenchymal lesion with a predilection of involving the vulva of prepubertal girls or adults in rare cases. PVF may represent an overgrowth of normal stromal tissue of vulva. Approximately one third of the tumors develop local recurrence due to incomplete excision, however, there is also occasionally spontaneous regression.
authors.affiliation: Department of Pathology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, China.
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.forename: Yu-qing
authors.initials: YQ
authors.lastname: Ma
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D005350:Fibroma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D009232:Myxoma / Q000473:pathology; D009364:Neoplasm Recurrence, Local; D014746:Vimentin / Q000378:metabolism*; D014844:Vulva / Q000473:pathology / Q000601:surgery; D014846:Vulvar Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery
chemical_list: D018952:Antigens, CD34; D014746:Vimentin