Plasma levels of inter-alpha inhibitor proteins in children with acute Dengue virus infection.
BACKGROUND
Inter-alpha inhibitor proteins (IaIp) belong to a family of protease inhibitors that are involved in the haemostatic and the vascular system. Dengue viruses (DENV) infections are characterized by coagulopathy and increased vascular permeability. In this study we measured the concentration of IaIp during DENV infections and evaluated its potential as a biomarker.


RESULTS
Concentrations of IaIp were measured in patients with acute DENV infections using a quantitative, competitive enzyme linked immunoassay. Concentrations of IaIp measured in pediatric patients suffering from severe DENV infections were significantly lower than in healthy controls.


CONCLUSIONS
This is the first report to demonstrate changes in concentration of IaIp during viral infections. The data also highlight the potential of IaIp as a biological marker for severity of DENV infections.
Koraka
Penelope
P
Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands.
Lim
Yow-Pin
YP
Shin
Michael D
MD
Setiati
Tatty E
TE
Mairuhu
Albert T A
AT
van Gorp
Eric C M
EC
Soemantri
Augustinus
A
Osterhaus
Albert D M E
AD
Martina
Byron E E
BE
D000208:Acute Disease; D000293:Adolescent; D000510:Alpha-Globulins / Q000032:analysis*; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003715:Dengue / Q000097:blood / Q000175:diagnosis*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods / Q000592:standards; D005260:Female; D006801:Humans; D008297:Male
D000510:Alpha-Globulins; D015415:Biomarkers; C011877:inter-alpha-inhibitor
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