The effects of progesterone pretreatment on the response to oral d-amphetamine in Women.
Stimulant abuse continues to be a problem, particularly for women. There is increasing preclinical and clinical evidence showing that the hormone progesterone attenuates the behavioral effects of cocaine, and this effect is primarily observed in females. The purpose of the present study was to determine if progesterone would also alter the behavioral effects of another stimulant, oral d-amphetamine (AMPH) in women. Eighteen normal non-drug abusing women completed eight outpatient sessions over two menstrual cycles. During the follicular phase of each cycle, women were administered AMPH (0, 10, 20 mg); in one cycle they were pretreated with oral micronized progesterone (200 mg) and in another cycle they were pretreated with placebo progesterone. Each session, participants completed a range of tasks including subjective measures of abuse liability, cognitive performance tasks, and behavioral measures of impulsivity and risk-taking. AMPH produced dose-related increases in positive subjective effects and these effects were enhanced by progesterone pretreatment. AMPH alone, or in combination with progesterone, had little effect on performance or behavioral measures of impulsivity. These results are in contrast with previous studies showing that progesterone attenuates the subjective response to cocaine and nicotine. Additional studies are needed to explore the modulatory role of progesterone on the effects of AMPH to determine whether progesterone has any clinical utility for AMPH abuse.
Reed
Stephanie C
SC
Division on Substance Abuse, New York State Psychiatric Institute and Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA. sc2432@columbia.edu
Levin
Frances R
FR
Evans
Suzette M
SM
D000284:Administration, Oral; D000328:Adult; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D003071:Cognition / Q000187:drug effects*; D003913:Dextroamphetamine / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007175:Impulsive Behavior; D008597:Menstrual Cycle; D010919:Placebos; D011374:Progesterone / Q000008:administration & dosage*; D012309:Risk-Taking
D000697:Central Nervous System Stimulants; D010919:Placebos; D011374:Progesterone; D003913:Dextroamphetamine
Exp Clin Psychopharmacol. 2007 Apr;15(2):123-33
17469936
Psychopharmacology (Berl). 2007 Jun;192(2):171-82
17265075
Behav Brain Res. 1989 Nov 1;35(2):117-25
2818831
Drug Alcohol Depend. 2007 Jul 10;89(2-3):183-9
17240083
J Clin Psychol. 1995 Nov;51(6):768-74
8778124
Brain Res Bull. 2006 Jan 30;68(5):310-4
16377436
Exp Clin Psychopharmacol. 2007 Dec;15(6):599-609
18179313
Behav Res Methods Instrum Comput. 2002 Aug;34(3):391-8
12395555
Pharmacol Biochem Behav. 2002 Nov;73(4):729-41
12213517
Pharmacol Biochem Behav. 2002 May;72(1-2):431-5
11900816
J Child Psychol Psychiatry. 2003 Nov;44(8):1145-57
14626456
Exp Clin Psychopharmacol. 1999 Aug;7(3):274-83
10472516
Clin Ther. 1999 Jan;21(1):41-60; discussion 1-2
10090424
Prog Neuropsychopharmacol Biol Psychiatry. 1995 May;19(3):491-7
7624499
Alcohol Clin Exp Res. 1993 Feb;17(1):140-6
8452195
Neuroendocrinology. 1990 Nov;52(5):517-20
2126359
J Exp Psychol Gen. 1999 Mar;128(1):78-87
10100392
Brain Res. 2008 Jan 16;1189:229-35
18067879
Horm Behav. 2010 Jun;58(1):13-21
19733571
Psychoneuroendocrinology. 2004 Apr;29(3):339-54
14644065
J Stud Alcohol. 2002 Jan;63(1):83-90
11925063
Behav Neurosci. 2000 Aug;114(4):830-7
10959541
Am J Psychiatry. 2009 Oct;166(10):1170-7
19723785
Psychopharmacology (Berl). 2001 Mar;154(3):243-50
11351931
Behav Genet. 2010 Mar;40(2):255-61
20091113
Psychopharmacology (Berl). 2005 Jul;180(2):294-305
15717210
Psychopharmacology (Berl). 2006 Nov;189(1):17-25
16972106
Horm Behav. 2010 Jun;58(1):44-56
19818789
Pharmacotherapy. 2007 May;27(5):666-74
17461701
Exp Clin Psychopharmacol. 2007 Oct;15(5):418-26
17924776
Neuropsychopharmacology. 1998 Dec;19(6):499-516
9803426
Fertil Steril. 1993 Jul;60(1):26-33
8513955
Drug Alcohol Depend. 2008 Jul 1;96(1-2):111-20
18378098
Psychopharmacology (Berl). 2002 Feb;159(4):397-406
11823892
Hum Psychopharmacol. 2003 Jun;18(4):291-9
12766934
Neuropsychopharmacology. 2005 Apr;30(4):669-82
15688093
Drug Alcohol Depend. 2005 Feb 14;77(2):151-9
15664716
Hum Psychopharmacol. 2009 Oct;24(7):559-64
19743227
Pharmacol Biochem Behav. 2001 May-Jun;69(1-2):299-304
11420098
Psychoneuroendocrinology. 2006 Nov;31(10):1190-9
17034954
J Pers Assess. 1996 Dec;67(3):588-97
8991972
Pharmacol Biochem Behav. 2005 Jul;81(3):559-68
15936062
Psychon Bull Rev. 1996 Mar;3(1):100-4
24214810
Front Neuroendocrinol. 2002 Jan;23(1):41-100
11906203
Trends Pharmacol Sci. 2004 May;25(5):273-9
15120494
J Reprod Med. 1995 Jul;40(7):521-4
7473442
J Pharmacol Exp Ther. 1994 Nov;271(2):683-94
7965783
Psychoneuroendocrinology. 2009 Apr;34(3):343-52
18977603
J Exp Psychol Appl. 2002 Jun;8(2):75-84
12075692
Psychopharmacology (Berl). 1999 Jul;145(1):67-75
10445374
Exp Clin Psychopharmacol. 2007 Oct;15(5):472-80
17924781
Neuropsychopharmacology. 2006 Mar;31(3):659-74
16160708
Pharmacol Biochem Behav. 2004 Aug;78(4):699-705
15301924
Behav Pharmacol. 1993 Feb;4(1):3-13
11224166
Appetite. 1999 Jun;32(3):331-49
10336792
Psychopharmacology (Berl). 2009 Mar;203(1):63-72
18998113
Neuropsychopharmacology. 2006 Jan;31(1):129-38
15920500
J Am Pharm Assoc (2003). 2009 Jul-Aug;49(4):519-28
19589764
Exp Clin Psychopharmacol. 2007 Oct;15(5):445-52
17924778
FASEB J. 1992 Mar;6(6):2311-22
1347506
Exp Clin Psychopharmacol. 2010 Feb;18(1):78-86
20158297
Exp Clin Psychopharmacol. 2007 Oct;15(5):453-60
17924779
J Consult Clin Psychol. 1978 Feb;46(1):139-49
627648
Psychiatry Res. 1998 Jan 16;77(1):35-42
10710173
Br J Clin Pharmacol. 1992 Mar;33(3):293-8
1576050
Neuropsychopharmacology. 2007 Sep;32(9):1956-66
17251908
Drug Alcohol Depend. 2004 May 10;74(2):147-58
15099658
Psychopharmacology (Berl). 1989;98(3):408-11
2501818
Drug Alcohol Depend. 2010 Mar 1;107(2-3):264-7
20005642
Pharmacol Biochem Behav. 2007 Jun-Jul;87(2):258-66
17544491
Neuropsychopharmacology. 2002 Nov;27(5):813-25
12431855
Pharmacol Biochem Behav. 2009 Sep;93(3):337-42
19447128
Pharmacol Biochem Behav. 1982 Jun;16(6):875-9
7202216
Behav Res Methods. 2005 Feb;37(1):82-90
16097347
Psychopharmacology (Berl). 2000 May;150(1):90-101
10867981
J Neurosci. 2005 Apr 13;25(15):3932-9
15829645
Neuropsychopharmacology. 2008 Jul;33(8):1847-55
17851535
Exp Clin Psychopharmacol. 2007 Oct;15(5):461-71
17924780
Subst Use Misuse. 2004 Jun;39(7):1095-116
15387205
Psychoneuroendocrinology. 2001 Oct;26(7):697-710
11500251
Addict Behav. 2007 Jun;32(6):1177-88
17011712