Differential integrin expression by T lymphocytes: potential role in DMD muscle damage.
The expression and function of integrin-type extracellular matrix receptors, VLA-4 and VLA-5, and laminin receptor VLA-6 on the surface of CD3(+)CD4(+) and CD3(+)CD8(+) defined T cell populations was evaluated in the blood of Duchenne muscular dystrophy (DMD) patients and healthy individuals. Both the number of CD4(+) and CD8(+) T cell subsets expressing VLA-4 or VLA-5 and the fibronectin-driven T cell migration was significantly higher in DMD patients. These data indicate that interactions of VLA-4 and/or VLA-5 with fibronectin may drive T lymphocytes to specific niches within muscle, contributing to tissue damage and fibrosis in DMD patients.
Pinto-Mariz
Fernanda
F
Laboratory of Thymus Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
Carvalho
Luciana Rodrigues
LR
de Mello
Wallace
W
Araújo
Alexandra de Queiroz Campos
Ade Q
Ribeiro
Márcia Gonçalves
MG
Cunha
Maria do Carmo Soares Alves
Mdo C
Voit
Thomas
T
Butler-Browne
Gillian
G
Silva-Barbosa
Suse Dayse
SD
Savino
Wilson
W
D000293:Adolescent; D002465:Cell Movement / Q000235:genetics / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D039001:Integrin alpha Chains / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D039081:Integrin alpha5beta1 / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D039121:Integrin alpha6beta1 / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D016023:Integrins / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D018482:Muscle, Skeletal / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology*; D020388:Muscular Dystrophy, Duchenne / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology*; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology
C063493:CDw49d; D039001:Integrin alpha Chains; D039081:Integrin alpha5beta1; D039121:Integrin alpha6beta1; D016023:Integrins