title: Squaramide-catalyzed enantioselective Friedel-Crafts reaction of indoles with imines.
abstract: Chiral squaramides are highly enantioselective catalysts for Friedel-Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85-96% yields and 84-96% ees.
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Qian
authors.forename: Gaoyuan
authors.initials: G
authors.lastname: Ma
authors.forename: Aifeng
authors.initials: A
authors.lastname: Lv
authors.forename: Hai-Liang
authors.initials: HL
authors.lastname: Zhu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Viresh H
authors.initials: VH
authors.lastname: Rawal
mesh_terms: D000577:Amides / Q000737:chemistry*; D002384:Catalysis; D007097:Imines / Q000138:chemical synthesis / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000577:Amides; D007097:Imines; D007211:Indoles