New loci associated with kidney function and chronic kidney disease.
Chronic kidney disease (CKD) is a significant public health problem, and recent genetic studies have identified common CKD susceptibility variants. The CKDGen consortium performed a meta-analysis of genome-wide association data in 67,093 individuals of European ancestry from 20 predominantly population-based studies in order to identify new susceptibility loci for reduced renal function as estimated by serum creatinine (eGFRcrea), serum cystatin c (eGFRcys) and CKD (eGFRcrea < 60 ml/min/1.73 m(2); n = 5,807 individuals with CKD (cases)). Follow-up of the 23 new genome-wide-significant loci (P < 5 x 10(-8)) in 22,982 replication samples identified 13 new loci affecting renal function and CKD (in or near LASS2, GCKR, ALMS1, TFDP2, DAB2, SLC34A1, VEGFA, PRKAG2, PIP5K1B, ATXN2, DACH1, UBE2Q2 and SLC7A9) and 7 loci suspected to affect creatinine production and secretion (CPS1, SLC22A2, TMEM60, WDR37, SLC6A13, WDR72 and BCAS3). These results further our understanding of the biologic mechanisms of kidney function by identifying loci that potentially influence nephrogenesis, podocyte function, angiogenesis, solute transport and metabolic functions of the kidney.
Köttgen
Anna
A
Department of Epidemiology, Johns Hopkins University, Baltimore, Maryland, USA.
Pattaro
Cristian
C
Böger
Carsten A
CA
Fuchsberger
Christian
C
Olden
Matthias
M
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Nicole L
NL
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A
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Yang
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Q
Smith
Albert V
AV
O'Connell
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JR
Li
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M
Schmidt
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H
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T
Isaacs
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A
Ketkar
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S
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Johnson
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AD
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A
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A
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EJ
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MC
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E
Struchalin
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M
Cavalieri
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M
Singleton
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A
Giallauria
Francesco
F
Metter
Jeffrey
J
de Boer
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IH
Haritunians
Talin
T
Lumley
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T
Siscovick
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D
Psaty
Bruce M
BM
Zillikens
M Carola
MC
Oostra
Ben A
BA
Feitosa
Mary
M
Province
Michael
M
de Andrade
Mariza
M
Turner
Stephen T
ST
Schillert
Arne
A
Ziegler
Andreas
A
Wild
Philipp S
PS
Schnabel
Renate B
RB
Wilde
Sandra
S
Munzel
Thomas F
TF
Leak
Tennille S
TS
Illig
Thomas
T
Klopp
Norman
N
Meisinger
Christa
C
Wichmann
H-Erich
HE
Koenig
Wolfgang
W
Zgaga
Lina
L
Zemunik
Tatijana
T
Kolcic
Ivana
I
Minelli
Cosetta
C
Hu
Frank B
FB
Johansson
Asa
A
Igl
Wilmar
W
Zaboli
Ghazal
G
Wild
Sarah H
SH
Wright
Alan F
AF
Campbell
Harry
H
Ellinghaus
David
D
Schreiber
Stefan
S
Aulchenko
Yurii S
YS
Felix
Janine F
JF
Rivadeneira
Fernando
F
Uitterlinden
Andre G
AG
Hofman
Albert
A
Imboden
Medea
M
Nitsch
Dorothea
D
Brandstätter
Anita
A
Kollerits
Barbara
B
Kedenko
Lyudmyla
L
Mägi
Reedik
R
Stumvoll
Michael
M
Kovacs
Peter
P
Boban
Mladen
M
Campbell
Susan
S
Endlich
Karlhans
K
Völzke
Henry
H
Kroemer
Heyo K
HK
Nauck
Matthias
M
Völker
Uwe
U
Polasek
Ozren
O
Vitart
Veronique
V
Badola
Sunita
S
Parker
Alexander N
AN
Ridker
Paul M
PM
Kardia
Sharon L R
SL
Blankenberg
Stefan
S
Liu
Yongmei
Y
Curhan
Gary C
GC
Franke
Andre
A
Rochat
Thierry
T
Paulweber
Bernhard
B
Prokopenko
Inga
I
Wang
Wei
W
Gudnason
Vilmundur
V
Shuldiner
Alan R
AR
Coresh
Josef
J
Schmidt
Reinhold
R
Ferrucci
Luigi
L
Shlipak
Michael G
MG
van Duijn
Cornelia M
CM
Borecki
Ingrid
I
Krämer
Bernhard K
BK
Rudan
Igor
I
Gyllensten
Ulf
U
Wilson
James F
JF
Witteman
Jacqueline C
JC
Pramstaller
Peter P
PP
Rettig
Rainer
R
Hastie
Nick
N
Chasman
Daniel I
DI
Kao
W H
WH
Heid
Iris M
IM
Fox
Caroline S
CS
D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D055316:Cystatin C / Q000235:genetics; D004032:Diet; D005060:Europe; D005819:Genetic Markers / Q000235:genetics; D055106:Genome-Wide Association Study; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007676:Kidney Failure, Chronic / Q000208:ethnology / Q000235:genetics*; D008957:Models, Genetic; D012307:Risk Factors
D055316:Cystatin C; D005819:Genetic Markers; D003404:Creatinine
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