Propetamphos-induced changes in haematological and biochemical parameters of female rats: protective role of propolis.
The present study was conducted to investigate the effectiveness of propolis in alleviating the toxicity of propetamphos on haematological and biochemical parameters in rats. Twenty-four female Wistar-Albino rats (200-250 g) were randomly divided into four equal groups of six rats each. As normal drinking water was given to the control group, propolis (100 mg/kg bw/day), propetamphos (15 mg/kg bw/day), and propolis (100 mg/kg bw/day) with propetamphos (15 mg/kg bw/day) combinations were given to the other three groups by adding to drinking water for 28 days, respectively. The levels of glucose and triglyceride, and the activities of aspartate aminotransferase (AST), alkaline phosphatase (ALP), and alanine aminotransferase (ALT) were increased, and total protein was decreased in serum of rats treated with propetamphos. Lymphocyte percentage was increased, while neutrophil percentage and total leukocyte counts were decreased due to propetamphos administration. In conclusion, propetamphos was determined to cause harmful effects in rats, and the administration of propolis to these animals alleviated the harmful effects of propetamphos.
Cetin
Ebru
E
Department of Physiology, Faculty of Veterinary Medicine, University of Erciyes, Kayseri, Turkey. ecetin@erciyes.edu.tr
Kanbur
Murat
M
Silici
Sibel
S
Eraslan
Gökhan
G
D000818:Animals; D001774:Blood Chemical Analysis; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D007306:Insecticides / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D007958:Leukocyte Count; D008111:Liver Function Tests; D009946:Organothiophosphorus Compounds / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D011429:Propolis / Q000737:chemistry / Q000494:pharmacology*; D020011:Protective Agents; D051381:Rats; D017208:Rats, Wistar
D007306:Insecticides; D009946:Organothiophosphorus Compounds; D020011:Protective Agents; D011429:Propolis; C035967:propetamphos