title: Synthesis of 1H-indole-2,3-dione-3-thiosemicarbazone ribonucleosides as antibacterial agents.
abstract: A new isatin ribonucleoside (3) was synthesized in a good yield by trimethylsilyl trifluoromethanesulfonate (TMSOTf) catalyzed coupling reaction between the silylated nitrogenated base of 1H-Indole-2,3-dione (1) and 1,2,3,5-tetra-O-acetyl-beta-D-ribfuranose (2). Thiosemicarbazides 4a-e were utilized by the prepared ribonucleoside (3) to give new series of 1H-indole-2,3-dione-3-thiosemicarbazone ribonucleosides 5a-e. All compounds tested as antibacterial agents showed slight inhibitory activity against the selected bacterial strains.
authors.affiliation: Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Misr International University, Cairo, Egypt.
authors.forename: Shaymaa E
authors.initials: SE
authors.lastname: Kassab
authors.forename: Gehan H
authors.initials: GH
authors.lastname: Hegazy
authors.forename: Nahed M
authors.initials: NM
authors.lastname: Eid
authors.forename: Kamelia M
authors.initials: KM
authors.lastname: Amin
authors.forename: Adel A
authors.initials: AA
authors.lastname: El-Gendy
mesh_terms: D000478:Alkylation / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D007536:Isomerism; D008826:Microbial Sensitivity Tests; D012263:Ribonucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013882:Thiosemicarbazones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D012263:Ribonucleosides; D013882:Thiosemicarbazones