[Influence of prothrombin cleavage products on platelet activation and aggregation].
Meizothrombin efficiently activates mechanically triggered platelets and enhance collagen-, ADP- and adrenalin-induced aggregation of platelet-rich blood plasma. Thus, in clotting system activation zone meizothrombin is able to enhance process of involving platelets in clotformation. Pre-thrombin 1 inhibits collagen-, ADP- and adrenalin-induced aggregation of platelet-rich blood plasma and so regulates not only plasm but platelet hemostasis by reverse negative relation.
Korol'ova
D S
DS
Chernyshenko
V O
VO
Hornyts'ka
O V
OV
Platonova
T M
TM
D001777:Blood Coagulation / Q000502:physiology; D001792:Blood Platelets / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D015539:Platelet Activation / Q000187:drug effects / Q000502:physiology; D010974:Platelet Aggregation / Q000187:drug effects* / Q000502:physiology; D011516:Prothrombin / Q000302:isolation & purification / Q000494:pharmacology* / Q000502:physiology
D011516:Prothrombin