Development of recombinant cationic polymers for gene therapy research.
Cationic polymers created through recombinant DNA technology have the potential to fill a void in the area of gene delivery. The recombinant cationic polymers to be discussed here are amino acid based polymers synthesized in E. coli with the purpose to not only address the major barriers to efficient gene delivery but offer safety, biodegradability, targetability and cost-effectiveness. This review helps the readers to get a better understanding about the evolution of recombinant cationic polymers; and the potential advantages that they could offer over viral and synthetic non-viral vectors for gene delivery. It also discusses some of the major challenges that must be addressed in future studies to turn recombinant polymers into clinically effective gene delivery systems. Recent advances with the biopolymer design suggest that this emerging new class of gene delivery systems has the potential to address some of the major barriers to efficient, safe and cost-effective gene therapy.
Canine
Brenda F
BF
Department of Pharmaceutical Sciences, Center for Integrated Biotechnology, Washington State University, Pullman, 99164, USA.
Hatefi
Arash
A
D026923:Amino Acid Transport Systems, Basic / Q000008:administration & dosage* / Q000737:chemistry*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D011108:Polymers / Q000008:administration & dosage* / Q000737:chemistry*; D011994:Recombinant Proteins / Q000008:administration & dosage* / Q000737:chemistry*
D026923:Amino Acid Transport Systems, Basic; D011108:Polymers; D011994:Recombinant Proteins
Pharm Res. 2008 Mar;25(3):683-91
17762916
Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12646-50
17563361
Nat Rev Genet. 2003 May;4(5):346-58
12728277
J Biol Chem. 2002 Oct 11;277(41):38895-900
12140285
Biotechnol Bioeng. 2000 Dec 20;70(6):593-605
11064328
Biochemistry. 2003 Sep 9;42(35):10343-7
12950160
Cancer Res. 2006 Apr 15;66(8):4339-48
16618759
Biomaterials. 2010 Mar;31(7):1830-8
19942284
J Gene Med. 2006 Apr;8(4):468-76
16416505
Pharm Res. 2007 Dec;24(12):2402-11
17828616
Gene Ther Mol Biol. 2009;13(A):15-19
19503758
Biochemistry. 1997 Feb 4;36(5):1041-51
9033394
J Control Release. 2006 Aug 10;114(1):100-9
16831482
J Cell Biol. 1995 May;129(3):551-60
7730395
Biotechnol Appl Biochem. 2009 Jul 06;54(1):1-9
19575694
Mol Pharm. 2006 Nov-Dec;3(6):726-36
17140260
Nat Rev Drug Discov. 2005 Jul;4(7):581-93
16052241
J Control Release. 2008 Jul 14;129(2):117-23
18524409
Curr Protoc Protein Sci. 2007 Nov;Chapter 18:Unit 18.8
18429312
Biomacromolecules. 2002 Mar-Apr;3(2):357-67
11888323
Gene. 1996 Nov 21;180(1-2):101-6
8973352
J Control Release. 2009 Sep 15;138(3):188-96
19379785
Proc Natl Acad Sci U S A. 1995 Aug 1;92(16):7297-301
7638184
Biotechnol Bioeng. 2000 Jun 20;68(6):689-96
10799995
Expert Opin Drug Deliv. 2008 Aug;5(8):847-59
18712995
AAPS PharmSci. 2002;4(3):E12
12423061
Biotechnol Adv. 2009 May-Jun;27(3):297-306
19500547