title: Tandem processes identified from reaction screening: nucleophilic addition to aryl N-phosphinylimines employing La(III)-TFAA activation.
abstract: Reaction screening of nucleophilic reaction partners for addition to N-diphenylphosphinylimines employing lanthanum(III) triflate as a catalyst and trifluoroacetic anhydride (TFAA) as an activator is reported. A number of tandem processes leading to novel chemotypes including aza-Prins/intramolecular Friedel-Crafts annulations have been identified, and both reaction scope and mechanism further investigated.
authors.affiliation: Department of Chemistry and Center for Chemical Methodology and Library Development (CMLD-BU), Boston University, Boston, Massachusetts 02215, USA.
authors.forename: Hidenori
authors.initials: H
authors.lastname: Kinoshita
authors.forename: Oscar J
authors.initials: OJ
authors.lastname: Ingham
authors.forename: Winnie W
authors.initials: WW
authors.lastname: Ong
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Beeler
authors.forename: John A
authors.initials: JA
authors.lastname: Porco
mesh_terms: D000089:Acetic Anhydrides; D002384:Catalysis; D005463:Fluoroacetates; D007097:Imines / Q000737:chemistry*; D007811:Lanthanum / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010720:Phosphines / Q000737:chemistry*; D011789:Quantum Theory; D014269:Trifluoroacetic Acid / Q000737:chemistry
chemical_list: D000089:Acetic Anhydrides; D005463:Fluoroacetates; D007097:Imines; D010720:Phosphines; C017958:trifluoroacetic anhydride; D007811:Lanthanum; D014269:Trifluoroacetic Acid
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