Molecular determinants of the cardiometabolic phenotype.
The metabolic syndrome represents a clustering of risk factors that has been shown to predict adverse cardiovascular outcomes. Although the precise mechanisms contributing to the cardiometabolic syndrome (CMS) remain poorly defined, accumulating evidence identifies two intersecting candidate pathways responsible for inflammation and energy homeostasis in the pathophysiology that underlie cardiometabolic traits. Although currently no pharmacologic interventions specifically target CMS, future drug development efforts should attempt to capitalize on molecular nodes at the intersections of these pathways in the CMS.
de las Fuentes
Lisa
L
Cardiovascular Imaging and Clinical Research Core Laboratory, Cardiovascular Division, Washington University School of Medicine, St. Louis, MO 63110, USA. lfuentes@wustl.edu
de Simone
Giovanni
G
Arnett
Donna K
DK
Dávila-Román
Víctor G
VG
D002318:Cardiovascular Diseases / Q000150:complications* / Q000188:drug therapy; D005227:Fatty Acids / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006801:Humans; D007249:Inflammation / Q000150:complications*; D024821:Metabolic Syndrome / Q000209:etiology / Q000235:genetics*; D047492:Peroxisome Proliferator-Activated Receptors / Q000737:chemistry; D010641:Phenotype; D012307:Risk Factors; D040242:Risk Reduction Behavior
D005227:Fatty Acids; D047492:Peroxisome Proliferator-Activated Receptors
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