title: Arf GAPs: gatekeepers of vesicle generation.
abstract: Arf GAP proteins are a versatile and diverse group of proteins. They control the activity of the GTP-binding proteins of the ARF family by inducing the hydrolysis of GTP that is bound to Arf proteins. The best-studied role of Arf GAPs is in intracellular traffic. In this review, we will focus mainly on the Arf GAPs that play a role in vesicle formation, Arf GAP1, Arf GAP2 and Arf GAP3 and their yeast homologues, Gcs1p and Glo3p. We discuss the roles of Arf GAPs as regulators and effectors for Arf GTP-binding proteins.
authors.affiliation: University of Basel, Growth and Development, Biozentrum, Switzerland. anne.spang@unibas.ch
authors.forename: Anne
authors.initials: A
authors.lastname: Spang
authors.forename: Yoko
authors.initials: Y
authors.lastname: Shiba
authors.forename: Paul A
authors.initials: PA
authors.lastname: Randazzo
mesh_terms: D020727:ADP-Ribosylation Factors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D022162:Cytoplasmic Vesicles / Q000378:metabolism*; D020690:GTPase-Activating Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism
chemical_list: D020690:GTPase-Activating Proteins; D029701:Saccharomyces cerevisiae Proteins; D020727:ADP-Ribosylation Factors
references.citation: Cell. 1999 Mar 19;96(6):893-902
references.pmid: 10102276
references.citation: Traffic. 2007 Nov;8(11):1644-55
references.pmid: 17760859
references.citation: EMBO J. 1999 Sep 15;18(18):4935-48
references.pmid: 10487746
references.citation: J Cell Biol. 2008 Feb 25;180(4):713-20
references.pmid: 18283113
references.citation: Science. 1995 Dec 22;270(5244):1999-2002
references.pmid: 8533093
references.citation: Nat Struct Mol Biol. 2007 Feb;14(2):138-46
references.pmid: 17220896
references.citation: J Biol Chem. 2008 Aug 8;283(32):21965-77
references.pmid: 18541532
references.citation: J Biol Chem. 1994 Apr 8;269(14):10758-63
references.pmid: 8144664
references.citation: Trends Biochem Sci. 1998 Jul;23(7):257-62
references.pmid: 9697416
references.citation: Mol Cell Biol. 2007 Dec;27(23):8271-83
references.pmid: 17893324
references.citation: Cell Signal. 2009 Jul;21(7):1169-79
references.pmid: 19296914
references.citation: Cell. 2000 Mar 17;100(6):671-9
references.pmid: 10761932
references.citation: J Cell Sci. 2006 Jun 15;119(Pt 12):2604-12
references.pmid: 16735437
references.citation: Traffic. 2003 Feb;4(2):65-73
references.pmid: 12559033
references.citation: Mol Biol Cell. 1998 Jun;9(6):1323-37
references.pmid: 9614177
references.citation: Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5013-8
references.pmid: 10220410
references.citation: J Biol Chem. 2009 Jan 16;284(3):1652-63
references.pmid: 19017632
references.citation: J Cell Sci. 2006 Apr 1;119(Pt 7):1203-11
references.pmid: 16554436
references.citation: J Biol Chem. 2004 Sep 3;279(36):37677-84
references.pmid: 15231847
references.citation: Mol Biol Cell. 2003 Aug;14(8):3097-113
references.pmid: 12925749
references.citation: Annu Rev Cell Dev Biol. 2007;23:579-611
references.pmid: 17506703
references.citation: EMBO J. 1999 Feb 1;18(3):555-64
references.pmid: 9927415
references.citation: J Biol Chem. 1993 May 5;268(13):9555-63
references.pmid: 8486645
references.citation: J Cell Biol. 2008 Nov 17;183(4):725-35
references.pmid: 19015319
references.citation: Nature. 2003 Dec 4;426(6966):563-6
references.pmid: 14654841
references.citation: FEBS Lett. 1997 Aug 25;413(3):395-400
references.pmid: 9303543
references.citation: Yeast. 2003 Mar;20(4):315-30
references.pmid: 12627398
references.citation: Biochemistry. 2007 Feb 20;46(7):1779-90
references.pmid: 17253781
references.citation: Curr Biol. 2006 Jan 24;16(2):130-9
references.pmid: 16431365
references.citation: Cell. 1999 Apr 16;97(2):145-8
references.pmid: 10219233
references.citation: J Cell Biol. 2008 Feb 11;180(3):467-72
references.pmid: 18250197
references.citation: Curr Opin Cell Biol. 2002 Aug;14(4):423-7
references.pmid: 12383792
references.citation: Science. 2004 Jan 23;303(5657):495-9
references.pmid: 14645856
references.citation: J Biol Chem. 1995 Mar 10;270(10):5232-7
references.pmid: 7890632
references.citation: J Cell Sci. 2000 Jan;113 ( Pt 1):135-44
references.pmid: 10591632
references.citation: J Biol Chem. 2009 May 15;284(20):13948-13957
references.pmid: 19299515
references.citation: EMBO J. 1999 Dec 15;18(24):6890-8
references.pmid: 10601011
references.citation: J Biol Chem. 1995 Jun 16;270(24):14809-15
references.pmid: 7782347
references.citation: Nat Med. 2002 Oct;8(10):1059-62
references.pmid: 12357232
references.citation: EMBO J. 2005 Jul 6;24(13):2244-53
references.pmid: 15944734
references.citation: J Biol Chem. 2000 Aug 4;275(31):23615-9
references.pmid: 10811810
references.citation: Cell. 1999 Feb 19;96(4):495-506
references.pmid: 10052452
references.citation: Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10074-7
references.pmid: 8816753
references.citation: Mol Biol Cell. 2004 Sep;15(9):4064-72
references.pmid: 15254269
references.citation: EMBO J. 2005 Dec 7;24(23):4133-43
references.pmid: 16292346
references.citation: Traffic. 2009 Sep;10(9):1362-75
references.pmid: 19602196
references.citation: J Cell Biol. 2002 Oct 14;159(1):69-78
references.pmid: 12379802
references.citation: Mol Biol Cell. 2007 Aug;18(8):2852-63
references.pmid: 17522384
references.citation: Mol Biol Cell. 2009 Feb;20(3):859-69
references.pmid: 19109418
references.citation: J Cell Sci. 2002 Aug 15;115(Pt 16):3235-40
references.pmid: 12140255
references.citation: J Cell Biol. 2002 Apr 29;157(3):395-404
references.pmid: 11970962
references.citation: J Cell Biol. 2005 Jan 17;168(2):281-90
references.pmid: 15657398
references.citation: Traffic. 2007 Nov;8(11):1465-75
references.pmid: 17666108
references.citation: J Cell Sci. 1998 Oct;111 ( Pt 20):3081-90
references.pmid: 9739081
references.citation: J Cell Biol. 2001 Dec 24;155(7):1239-50
references.pmid: 11756474
references.citation: J Biol Chem. 1998 Jul 31;273(31):19792-6
references.pmid: 9677411
references.citation: Nature. 2005 Dec 1;438(7068):590-6
references.pmid: 16319878
references.citation: J Cell Biol. 2008 Sep 22;182(6):1039-44
references.pmid: 18809720
references.citation: Proc Natl Acad Sci U S A. 1987 Nov;84(22):7948-52
references.pmid: 3317397
references.citation: Biochem Soc Symp. 2005;(72):223-31
references.pmid: 15649145
references.citation: Proc Natl Acad Sci U S A. 2008 Nov 4;105(44):16946-51
references.pmid: 18974217