title: The association of magnetic resonance imaging measures with cognitive function in a biracial population sample.
abstract: BACKGROUND
  White matter hyperintensity volume (WMHV), cerebral infarcts, and total brain volume (TBV) are associated with cognitive function, but few studies have examined these associations in the general population or whether they differ by race.
  
  
  OBJECTIVE
  To examine the association of WMHV, cerebral infarcts, and TBV with global cognition and cognition in 5 separate domains in a biracial population sample.
  
  
  METHODS
  A biracial community population of Chicago, Illinois.
  
  
  METHODS
  Cross-sectional population study.
  
  
  METHODS
  The study population comprised 575 participants from the Chicago Health and Aging Project (CHAP).
  
  
  METHODS
  Volumetric magnetic resonance imaging (MRI) measures of WMHV, TBV, and cerebral infarcts and detailed neuropsychological testing assessments of global cognition and 5 cognitive domains.
  
  
  RESULTS
  Overall and among those without dementia, cognition was inversely associated with WMHV and number of infarcts but was positively associated with TBV. When all 3 measures were simultaneously added to the model, the association of global cognition with WMHV and TBV remained significant and unchanged but was no longer significant with infarcts. Among subjects without dementia, all 3 MRI measures were associated with performance in multiple cognitive domains, specifically perceptual speed. However, among subjects with dementia, only TBV was associated with cognition and performance in multiple cognitive systems. Race did not significantly modify any of these associations.
  
  
  CONCLUSIONS
  In this biracial general population sample, the associations of MRI measures with cognition differed according to clinical status of subjects (stronger among subjects without dementia) and were not modified by race. These associations did not affect all cognitive domains equally but were more consistent with impairments in perceptual speed.
authors.affiliation: Rush Alzheimer's Disease Center, 600 S Paulina Ave, Ste 1038, Chicago, IL 60612, USA. naggarw@rush.edu
authors.forename: Neelum T
authors.initials: NT
authors.lastname: Aggarwal
authors.forename: Robert S
authors.initials: RS
authors.lastname: Wilson
authors.forename: Julia L
authors.initials: JL
authors.lastname: Bienias
authors.forename: Philip L
authors.initials: PL
authors.lastname: De Jager
authors.forename: David A
authors.initials: DA
authors.lastname: Bennett
authors.forename: Denis A
authors.initials: DA
authors.lastname: Evans
authors.forename: Charles
authors.initials: C
authors.lastname: DeCarli
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D044383:Black People; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D020520:Brain Infarction / Q000453:epidemiology / Q000208:ethnology* / Q000473:pathology*; D001931:Brain Mapping; D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000208:ethnology / Q000473:pathology; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000453:epidemiology / Q000208:ethnology* / Q000473:pathology*; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009483:Neuropsychological Tests; D011594:Psychometrics; D044469:Racial Groups; D012307:Risk Factors; D044465:White People
references.citation: J Alzheimers Dis. 2003 Oct;5(5):349-55
references.pmid: 14646025
references.citation: J Magn Reson Imaging. 1996 May-Jun;6(3):519-28
references.pmid: 8724419
references.citation: Ann Neurol. 2002 Sep;52(3):335-41
references.pmid: 12205646
references.citation: Stroke. 2002 Oct;33(10):2376-82
references.pmid: 12364724
references.citation: Rev Neurol. 2003 Jul 16-31;37(2):140-4
references.pmid: 12938073
references.citation: Stroke. 2004 Jun;35(6):1270-5
references.pmid: 15118186
references.citation: J Clin Exp Neuropsychol. 1993 Sep;15(5):713-31
references.pmid: 8276931
references.citation: Arch Neurol. 2003 Feb;60(2):185-9
references.pmid: 12580702
references.citation: Stroke. 1999 Aug;30(8):1548-53
references.pmid: 10436099
references.citation: Arch Neurol. 2004 Oct;61(10):1531-4
references.pmid: 15477506
references.citation: J Clin Exp Neuropsychol. 2003 Aug;25(5):634-42
references.pmid: 12815501
references.citation: Neurology. 1999 Apr 12;52(6):1119-24
references.pmid: 10214731
references.citation: Stroke. 1999 Mar;30(3):529-36
references.pmid: 10066847
references.citation: Ann N Y Acad Sci. 2002 Nov;977:279-91
references.pmid: 12480762
references.citation: Neuropsychology. 2003 Jul;17(3):339-52
references.pmid: 12959500
references.citation: Neurology. 1989 Sep;39(9):1159-65
references.pmid: 2771064
references.citation: J Neural Transm (Vienna). 2002 May;109(5-6):813-36
references.pmid: 12111471
references.citation: Neurology. 2003 Apr 8;60(7):1082-8
references.pmid: 12682310
references.citation: Neurology. 2005 Jun 28;64(12):2056-62
references.pmid: 15985571
references.citation: Stroke. 1994 Jun;25(6):1109-15
references.pmid: 8202966
references.citation: Neurology. 2000 Jun 13;54(11):2108-14
references.pmid: 10851372
references.citation: Neurology. 1995 Nov;45(11):2077-84
references.pmid: 7501162
references.citation: Neurology. 2004 Nov 9;63(9):1591-9
references.pmid: 15534241
references.citation: Neuropsychologia. 2003;41(14):1929-41
references.pmid: 14572526
references.citation: Ann Neurol. 2007 Jul;62(1):59-66
references.pmid: 17503514
references.citation: Neurobiol Aging. 2005 Apr;26(4):491-510
references.pmid: 15653178
references.citation: Cerebrovasc Dis. 2002;13 Suppl 2:11-5
references.pmid: 11901237
references.citation: Neurology. 2007 Dec 11;69(24):2197-204
references.pmid: 17568013
references.citation: Arch Neurol. 2008 Aug;65(8):1053-61
references.pmid: 18695055
references.citation: J Comput Assist Tomogr. 1992 Mar-Apr;16(2):274-84
references.pmid: 1545026
references.citation: Neurology. 1993 Feb;43(2):250-60
references.pmid: 8094895
references.citation: Arch Neurol. 1992 Aug;49(8):839-45
references.pmid: 1343082
references.citation: Neurology. 2004 Jul 27;63(2):220-7
references.pmid: 15277612
references.citation: Int J Neurosci. 1991 Apr;57(3-4):167-78
references.pmid: 1938160
references.citation: Neuroepidemiology. 1997;16(3):149-62
references.pmid: 9159770
references.citation: Stroke. 2008 Mar;39(3):800-5
references.pmid: 18258844
references.citation: Stroke. 1997 Jun;28(6):1158-64
references.pmid: 9183343
references.citation: Neurology. 1998 Oct;51(4):986-93
references.pmid: 9781518
references.citation: Arch Neurol. 2006 Feb;63(2):246-50
references.pmid: 16476813
references.citation: Stroke. 2005 Jan;36(1):50-5
references.pmid: 15576652
references.citation: Neuroepidemiology. 2005;25(4):163-75
references.pmid: 16103727
references.citation: N Engl J Med. 2003 Mar 27;348(13):1215-22
references.pmid: 12660385
references.citation: Arch Neurol. 2006 Apr;63(4):571-6
references.pmid: 16606771
references.citation: Arch Neurol. 2009 Jun;66(6):767-72
references.pmid: 19506138
references.citation: J S C Med Assoc. 1999 Mar;95(3):116-8
references.pmid: 10204332
references.citation: Neurology. 1984 Jul;34(7):939-44
references.pmid: 6610841
references.citation: Ann Neurol. 2008 Jan;63(1):72-80
references.pmid: 18157909
references.citation: Psychol Aging. 2002 Jun;17(2):179-93
references.pmid: 12061405
references.citation: Int J Geriatr Psychiatry. 2005 Nov;20(11):1060-6
references.pmid: 16250078
references.citation: Arch Neurol. 1978 Jun;35(6):364-7
references.pmid: 655909
references.citation: Arch Neurol. 2008 Jan;65(1):94-100
references.pmid: 18195145
references.citation: Brain. 2005 Sep;128(Pt 9):2034-41
references.pmid: 15947059
references.citation: Magn Reson Imaging. 1994;12(3):387-94
references.pmid: 8007767
references.citation: J Neurol Neurosurg Psychiatry. 2007 Dec;78(12):1325-30
references.pmid: 17470472
references.citation: Arch Gen Psychiatry. 1996 Jul;53(7):585-94
references.pmid: 8660125
references.citation: Arch Neurol. 2001 Apr;58(4):643-7
references.pmid: 11295996
references.citation: AJNR Am J Neuroradiol. 1994 Apr;15(4):689-96
references.pmid: 8010271
references.citation: Neurology. 2005 Mar 22;64(6):1032-9
references.pmid: 15781822