title: MicroRNA-146a and human disease.
abstract: MicroRNAs (MiRNAs) belong to a class of small non-coding regulatory RNAs that act through repression of protein expression at post-transcriptional level and emerge to play important roles in many physiological and pathophysiological processes. MiR-146a is a miRNA supposed to regulate innate immune, inflammatory response and antiviral pathway negatively. In this review, we focus on the recent progress in functional role of miR-146a in innate immune, inflammatory response, virus infection and human diseases. Together, these findings indicate that manipulation of miR-146a expression may represent a potential new therapy for several human diseases. Potential use of miR-146a as a biomarker for disease diagnosis, prevention and treatment is also discussed.
authors.affiliation: Department of Pharmacology, School of Pharmaceutical Science, Central South University, Changsha, Hunan, China.
authors.forename: L
authors.initials: L
authors.lastname: Li
authors.forename: X-P
authors.initials: XP
authors.lastname: Chen
authors.forename: Y-J
authors.initials: YJ
authors.lastname: Li
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D006801:Humans; D007154:Immune System Diseases / Q000235:genetics*; D035683:MicroRNAs / Q000276:immunology*
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs