title: Ligands of the receptor for advanced glycation end products, including high-mobility group box 1, limit bacterial dissemination during Escherichia coli peritonitis.
abstract: OBJECTIVE
  The receptor for advanced glycation end products mediates a variety of inflammatory responses. Soluble receptor for advanced glycation end products has been suggested to function as a decoy abrogating cellular activation. High-mobility group box 1 is a high-affinity binding ligand for the receptor for advanced glycation end products with cytokine activities and plays a role in sepsis.
  
  
  METHODS
  Controlled, in vivo laboratory study.
  
  
  METHODS
  Research laboratory of a health sciences university.
  
  
  METHODS
  C57BL/6 mice.
  
  
  METHODS
  Peritonitis was induced by intraperitoneal injection of Escherichia coli. Mice received soluble receptor for advanced glycation end products or anti-high-mobility group box 1 immunoglobulin G, or the appropriate control treatment.
  
  
  RESULTS
  Soluble receptor for advanced glycation end products-treated mice demonstrated an enhanced bacterial dissemination to liver and lungs, accompanied by increased hepatocellular injury and exaggerated systemic cytokine release, 20 hrs after intraperitoneal administration of Escherichia coli. Soluble receptor for advanced glycation end products administration in healthy, uninfected mice did not induce an immune response. Remarkably, lung inflammation was unaffected. Furthermore, high-mobility group box 1 release was enhanced during peritonitis and anti-high-mobility group box 1 treatment was associated with higher bacterial loads in liver and lungs.
  
  
  CONCLUSIONS
  These data are the first to suggest that receptor for advanced glycation end products ligands, including high-mobility group box 1, limit bacterial dissemination during Gram-negative sepsis.
authors.affiliation: Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. M.A.D.vanZoelen@umcutrecht.nl
authors.forename: Marieke A D
authors.initials: MA
authors.lastname: van Zoelen
authors.forename: Ahmed
authors.initials: A
authors.lastname: Achouiti
authors.forename: Ann-Marie
authors.initials: AM
authors.lastname: Schmidt
authors.forename: Huan
authors.initials: H
authors.lastname: Yang
authors.forename: Sandrine
authors.initials: S
authors.lastname: Florquin
authors.forename: Kevin J
authors.initials: KJ
authors.lastname: Tracey
authors.forename: Tom
authors.initials: T
authors.lastname: van der Poll
mesh_terms: D000818:Animals; D018925:Chemokines / Q000378:metabolism; D004195:Disease Models, Animal; D004927:Escherichia coli Infections / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D005260:Female; D024243:HMGB1 Protein / Q000008:administration & dosage / Q000502:physiology*; D007113:Immunity, Innate / Q000502:physiology*; D007263:Infusions, Parenteral; D008024:Ligands; D008099:Liver / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D008168:Lung / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D020556:Neutrophil Infiltration; D010538:Peritonitis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000008:administration & dosage / Q000276:immunology*; D018805:Sepsis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology
chemical_list: D018925:Chemokines; D024243:HMGB1 Protein; D008024:Ligands; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic
references.citation: FASEB J. 2009 Jun;23(6):1766-74
references.pmid: 19164451
references.citation: Nat Med. 2000 Jun;6(6):643-51
references.pmid: 10835680
references.citation: Shock. 2009 Mar;31(3):280-4
references.pmid: 19218854
references.citation: J Immunol. 2006 Mar 15;176(6):3735-41
references.pmid: 16517742
references.citation: Pediatr Res. 2002 Aug;52(2):148-54
references.pmid: 12149489
references.citation: J Immunol. 2001 May 15;166(10):6323-31
references.pmid: 11342656
references.citation: J Immunol. 2002 Apr 1;168(7):3507-11
references.pmid: 11907112
references.citation: Nat Rev Drug Discov. 2005 Oct;4(10):854-65
references.pmid: 16224456
references.citation: J Exp Med. 2005 Apr 4;201(7):1135-43
references.pmid: 15795240
references.citation: Biochim Biophys Acta. 2000 Dec 20;1498(2-3):99-111
references.pmid: 11108954
references.citation: J Biol Chem. 2004 Feb 13;279(7):5059-65
references.pmid: 14617629
references.citation: J Biol Chem. 1999 Jul 9;274(28):19919-24
references.pmid: 10391939
references.citation: Blood. 2004 Mar 1;103(5):1702-9
references.pmid: 14592828
references.citation: FEBS Lett. 2003 Oct 9;553(1-2):11-7
references.pmid: 14550538
references.citation: Genes Immun. 2002 May;3(3):123-35
references.pmid: 12070776
references.citation: Crit Care. 2007;11(6):R122
references.pmid: 18042296
references.citation: Science. 1999 Jul 9;285(5425):248-51
references.pmid: 10398600
references.citation: J Exp Med. 2006 Jul 10;203(7):1637-42
references.pmid: 16818669
references.citation: Hepatology. 2004 Feb;39(2):422-32
references.pmid: 14767995
references.citation: Nat Med. 1998 Sep;4(9):1025-31
references.pmid: 9734395
references.citation: Adv Immunol. 2004;84:181-200
references.pmid: 15246253
references.citation: Cell. 1999 Jun 25;97(7):889-901
references.pmid: 10399917
references.citation: Nat Med. 2003 Mar;9(3):287-93
references.pmid: 12598893
references.citation: Rheum Dis Clin North Am. 2004 Aug;30(3):627-37, xi
references.pmid: 15261345
references.citation: J Exp Med. 2005 Feb 7;201(3):473-84
references.pmid: 15699076
references.citation: Infect Immun. 1997 Sep;65(9):3847-51
references.pmid: 9284162
references.citation: Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):296-301
references.pmid: 14695889
references.citation: Cardiovasc Diabetol. 2007 Mar 07;6:9
references.pmid: 17343760
references.citation: Clin Infect Dis. 1994 Jul;19(1):100-16
references.pmid: 7948510
references.citation: Diabetes. 2001 Dec;50(12):2792-808
references.pmid: 11723063
references.citation: Mol Cell Biol. 2004 Jun;24(11):4880-94
references.pmid: 15143181
references.citation: J Immunol. 2006 Jul 15;177(2):1189-96
references.pmid: 16818777
references.citation: J Infect Dis. 2004 Jun 15;189(12):2308-17
references.pmid: 15181580
references.citation: J Clin Invest. 2004 Jun;113(11):1641-50
references.pmid: 15173891
references.citation: J Infect Dis. 2005 Jun 15;191(12):2138-48
references.pmid: 15898001
references.citation: Nature. 1996 Aug 22;382(6593):685-91
references.pmid: 8751438
references.citation: Am J Pathol. 2001 Aug;159(2):513-25
references.pmid: 11485910
references.citation: Acta Crystallogr D Biol Crystallogr. 2002 Mar;58(Pt 3):407-13
references.pmid: 11856825
references.citation: J Gastroenterol Hepatol. 2006 Apr;21(4):682-8
references.pmid: 16677153
references.citation: J Biol Chem. 1995 Oct 27;270(43):25752-61
references.pmid: 7592757
references.citation: Am J Respir Crit Care Med. 2006 May 1;173(9):1008-15
references.pmid: 16456142
references.citation: Am J Physiol Regul Integr Comp Physiol. 2002 Jul;283(1):R7-28
references.pmid: 12069927
references.citation: Am J Respir Crit Care Med. 2003 Jan 15;167(2):171-9
references.pmid: 12406830
references.citation: Am J Respir Crit Care Med. 2002 May 15;165(10):1445-50
references.pmid: 12016110
references.citation: Virology. 2009 Sep 1;391(2):265-73
references.pmid: 19592063
references.citation: Arterioscler Thromb Vasc Biol. 2005 May;25(5):1032-7
references.pmid: 15731496
references.citation: Diabetes. 2004 Mar;53(3):743-51
references.pmid: 14988260
references.citation: Infection. 1991 Nov-Dec;19(6):447-52
references.pmid: 1816119
references.citation: Arthritis Rheum. 2006 Dec;54(12):3898-907
references.pmid: 17133598
references.citation: J Immunol. 2005 Nov 15;175(10):6764-71
references.pmid: 16272333