Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET).
OBJECTIVE
To assess the potential effects of short-term exposure to particulate air pollution during follicular phase on clinical, laboratory, and pregnancy outcomes of women undergoing IVF/ET.


METHODS
Retrospective cohort study of 400 first IVF/ET cycles of women exposed to ambient particulate matter during follicular phase. Particulate matter (PM) was categorized into quartiles (Q(1): < or =30.48 microg/m(3), Q(2): 30.49-42.00 microg/m(3), Q(3): 42.01-56.72 microg/m(3), and Q(4): >56.72 microg/m(3)).


RESULTS
Clinical, laboratory, or treatment variables were not affected by follicular phase PM exposure periods. Women exposed to Q(4) period during the follicular phase of conception cycles had a higher risk of miscarriage (odds ratio, 5.05; 95% confidence interval: 1.04-25.51) when compared to women exposed to Q(1-3) periods.


CONCLUSIONS
Our results show an association between brief exposure to high levels of ambient PM during the preconceptional period and early pregnancy loss, although no effect of this exposure on clinical, laboratory, and treatment outcomes was observed.
Perin
Paulo Marcelo
PM
Department of Pathology, University of São Paulo, Brazil. paulo@ceerh.com.br
Maluf
Mariangela
M
Czeresnia
Carlos Eduardo
CE
Januário
Daniela Aparecida Nicolosi Foltran
DA
Saldiva
Paulo Hilário Nascimento
PH
D000022:Abortion, Spontaneous / Q000209:etiology; D015331:Cohort Studies; D004624:Embryo Transfer; D005260:Female; D005306:Fertilization; D005307:Fertilization in Vitro; D005498:Follicular Phase / Q000378:metabolism; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D018811:Maternal Exposure / Q000009:adverse effects*; D052638:Particulate Matter / Q000633:toxicity*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies
D052638:Particulate Matter
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