Clinical status of duplex RNA.
Double-stranded RNA has become a ubiquitous tool for inhibition of gene expression in the laboratory. If similar success could be achieved in vivo, duplex RNA might provide a new class of therapeutics capable of treating a broad spectrum of disease. Chemists and biologists developing duplex RNA as a drug have made progress but continue to face challenges. This review presents the current status of duplex RNA in the clinic and comments on future prospects for the approach.
Watts
Jonathan K
JK
Departments of Pharmacology and Biochemistry, UT Southwestern Medical Center at Dallas, 6001 Forest Park Road, Dallas, TX 75390, USA.
Corey
David R
DR
D000818:Animals; D006801:Humans; D051379:Mice; D053758:Nanoparticles; D012330:RNA, Double-Stranded / Q000737:chemistry* / Q000494:pharmacology; D034741:RNA, Small Interfering; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics
D012330:RNA, Double-Stranded; D034741:RNA, Small Interfering; D042461:Vascular Endothelial Growth Factor A
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