Dissolvable films of silk fibroin for ultrathin conformal bio-integrated electronics.
Electronics that are capable of intimate, non-invasive integration with the soft, curvilinear surfaces of biological tissues offer important opportunities for diagnosing and treating disease and for improving brain/machine interfaces. This article describes a material strategy for a type of bio-interfaced system that relies on ultrathin electronics supported by bioresorbable substrates of silk fibroin. Mounting such devices on tissue and then allowing the silk to dissolve and resorb initiates a spontaneous, conformal wrapping process driven by capillary forces at the biotic/abiotic interface. Specialized mesh designs and ultrathin forms for the electronics ensure minimal stresses on the tissue and highly conformal coverage, even for complex curvilinear surfaces, as confirmed by experimental and theoretical studies. In vivo, neural mapping experiments on feline animal models illustrate one mode of use for this class of technology. These concepts provide new capabilities for implantable and surgical devices.
Kim
Dae-Hyeong
DH
Department of Materials Science and Engineering, Beckman Institute for Advanced Science and Technology and Frederick Seitz Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA.
Viventi
Jonathan
J
Amsden
Jason J
JJ
Xiao
Jianliang
J
Vigeland
Leif
L
Kim
Yun-Soung
YS
Blanco
Justin A
JA
Panilaitis
Bruce
B
Frechette
Eric S
ES
Contreras
Diego
D
Kaplan
David L
DL
Omenetto
Fiorenzo G
FG
Huang
Yonggang
Y
Hwang
Keh-Chih
KC
Zakin
Mitchell R
MR
Litt
Brian
B
Rogers
John A
JA
D000818:Animals; D002197:Capillary Action; D002415:Cats; D004566:Electrodes; D004581:Electronics / Q000295:instrumentation / Q000379:methods*; D005349:Fibroins; D018613:Microscopy, Confocal / Q000379:methods; D023421:Models, Animal; D019904:Polymethyl Methacrylate; D019736:Prostheses and Implants; D047011:Silk; D012995:Solubility; D013314:Stress, Mechanical; D013525:Surgical Instruments
D047011:Silk; D005349:Fibroins; D019904:Polymethyl Methacrylate
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