King of the castle: competition between repressors and activators on the Mcm1 platform.
Darieva and coworkers (Darieva et al., 2010) have shown that the repressor Yox1 and the activator Fkh2-Ndd1 associate with opposite sides of the dimeric Mcm1 transcription factor but nevertheless compete for binding; the outcome determines expression of late mitotic genes in yeast.
Leatherwood
Janet
J
Department of Molecular Genetics and Microbiology, Stony Brook University, Stony Brook, NY 11794-5222, USA.
Futcher
Bruce
B
D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D026341:Minichromosome Maintenance 1 Protein / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D046912:Multiprotein Complexes / Q000378:metabolism; D011485:Protein Binding; D055503:Protein Multimerization; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism
D018797:Cell Cycle Proteins; C464958:Fkh2 protein, S cerevisiae; D051858:Forkhead Transcription Factors; D018398:Homeodomain Proteins; D026341:Minichromosome Maintenance 1 Protein; D046912:Multiprotein Complexes; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; C080459:Yox1 protein, S cerevisiae