Renal cell carcinoma in young adults: a study of 130 cases and a review of previous series.
OBJECTIVE
To characterize a large series of renal cell carcinomas (RCCs) in young patients and to compare the data obtained to previously published data.


METHODS
A total of 130 RCCs diagnosed in patients <40 years of age were collected from 9 different hospitals in Spain. Cases were re-evaluated following the diagnostic criteria of the 2004 WHO classification of renal tumors.


RESULTS
Histologically, tumors were classified as clear cell (50.7%), papillary (8.5%), chromophobe (14.6%), unclassified (16.9%) and clear cell papillary (9.3%) RCCs. Organ-confined disease (OCD) was detected in 83.6% of the cases. Tumor size and Fuhrman's grade were statistically correlated (Spearman's rho = 0.391). CD10 (p = 0.000), CK7 (p = 0.000), CD15 (p = 0.016), CD117 (p = 0.000), 34betaE12 cytokeratin (p = 0.034) and e-cadherin (p = 0.000) immunostaining significantly differentiated the five histological categories.


CONCLUSIONS
OCD was more common in young RCC patients. The clear cell phenotype accounted for only 50% of RCCs in this age group, with an increasing number of chromophobe and unclassified RCCs. Clear cell RCCs with a papillary growth pattern accounted for a significant proportion of the cases.
López
José Ignacio
JI
Departments of Pathology, Hospital de Cruces-Osakidetza, Basque Country University (EHU/UPV), Barakaldo, Bizcaia, Spain. joseignacio.lopez@ehu.es
Moreno
Virginia
V
García
Huberto
H
Antón
Iosu
I
Robles
Antonio
A
Oñate
Juan M
JM
Baños
Angeles
A
Escandón
Jorge
J
Ugalde
Aitziber
A
D000293:Adolescent; D000328:Adult; D002292:Carcinoma, Renal Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D012189:Retrospective Studies; D055815:Young Adult