title: The expression of seven 14-3-3 isoforms in human meningioma.
abstract: 14-3-3 proteins comprise a large family of highly conserved, acidic polypeptides, expressed in all eukaryotic organisms, with highest concentration found in the brain. Multiple isoforms of 14-3-3 proteins have been shown to play an essential role in regulating differentiation, proliferation and transformation. In the previous study, the expression levels of all seven 14-3-3 isoforms were examined in astrocytoma. However, the expression of seven 14-3-3 isoforms in meningioma still remains unknown. This study is the first examination of 14-3-3 isoforms in three grades of meningioma by immunohistochemistry. 14-3-3epsilon, zeta and theta were specifically expressed in meningioma, and their expression levels increased with the increase of pathological grade of meningioma. The 14-3-3 eta, beta, gamma and sigma isoforms were negatively expressed in meningioma. In conclusion, The 14-3-3 epsilon, zeta and theta may be involved in tumorigenesis of meningioma and be efficient markers for predicting the degree of malignancy in meningioma.
authors.affiliation: Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Rui-feng
authors.initials: RF
authors.lastname: Tian
authors.forename: Yun-ming
authors.initials: YM
authors.lastname: Li
authors.forename: Wei-ping
authors.initials: WP
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Cao
authors.forename: Xiao-liang
authors.initials: XL
authors.lastname: Yang
authors.forename: Wei-dong
authors.initials: WD
authors.lastname: Cao
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhang
mesh_terms: D048948:14-3-3 Proteins / Q000096:biosynthesis*; D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002648:Child; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008577:Meningeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008579:Meningioma / Q000378:metabolism* / Q000473:pathology*; D008875:Middle Aged; D020033:Protein Isoforms / Q000096:biosynthesis; D055815:Young Adult
chemical_list: D048948:14-3-3 Proteins; D014408:Biomarkers, Tumor; D020033:Protein Isoforms