Small cell gallbladder carcinoma complicated by paraneoplastic hyponatremia: a case report and literature review.
BACKGROUND
Gallbladder carcinoma has been associated with various paraneoplastic syndromes. These may be the presenting manifestations that lead the clinician to a diagnosis.


METHODS
We report a case of small cell gallbladder carcinoma complicated by paraneoplastic hyponatremia. The hyponatremia was further exacerbated by platinum-based chemotherapy.


CONCLUSIONS
There have previously been no reports of paraneoplastic hyponatremia in gallbladder carcinoma. We discuss the management of this problem and also provide a short literature review on the other paraneoplastic syndromes associated with gallbladder carcinoma.


CONCLUSIONS
Symptoms and signs of gallbladder cancer may be insidious. Thorough workup is needed if the patient presents with symptoms and signs of a paraneoplastic syndrome.
Ng
Esther S
ES
Department of Medicine, National University Health System, Singapore, Singapore.
Venkateswaran
Kotamma
K
Ganpathi
Shridhar I
SI
Chuah
Benjamin Y
BY
D000328:Adult; D018288:Carcinoma, Small Cell / Q000150:complications / Q000473:pathology*; D005260:Female; D005706:Gallbladder Neoplasms / Q000150:complications / Q000473:pathology*; D006801:Humans; D007010:Hyponatremia / Q000209:etiology* / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000473:pathology*
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