Transmission of hemagglutinin D222G mutant strain of pandemic (H1N1) 2009 virus.
A pandemic (H1N1) 2009 virus strain carrying the D222G mutation was identified in a severely ill man and was transmitted to a household contact. Only mild illness developed in the contact, despite his obesity and diabetes. The isolated virus reacted fully with an antiserum against the pandemic vaccine strain.
Puzelli
Simona
S
National Institute of Health, Rome, Italy. simona.puzelli@iss.it
Facchini
Marzia
M
Spagnolo
Domenico
D
De Marco
Maria A
MA
Calzoletti
Laura
L
Zanetti
Alessandro
A
Fumagalli
Roberto
R
Tanzi
Maria L
ML
Cassone
Antonio
A
Rezza
Giovanni
G
Donatelli
Isabella
I
D000328:Adult; D019943:Amino Acid Substitution; D004196:Disease Outbreaks; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics* / Q000302:isolation & purification; D007251:Influenza, Human / Q000453:epidemiology / Q000503:physiopathology / Q000635:transmission* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D010802:Phylogeny; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D012189:Retrospective Studies; D017423:Sequence Analysis, RNA; D012720:Severity of Illness Index
D019267:Hemagglutinin Glycoproteins, Influenza Virus; D012367:RNA, Viral
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