Progress in epidermolysis bullosa research: toward treatment and cure.
Epidermolysis bullosa (EB) is a clinically and genetically heterogeneous group of blistering disorders with considerable morbidity and mortality. Two decades ago, EB entered the molecular era with the identification of mutations in specific genes expressed within the cutaneous basement membrane zone; mutations in 14 genes have now been identified. This progress has now formed the basis for development of novel molecular therapies for this disease.
Uitto
Jouni
J
Department of Dermatology and Cutaneous Biology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. jouni.uitto@jefferson.edu
McGrath
John A
JA
Rodeck
Ulrich
U
Bruckner-Tuderman
Leena
L
Robinson
E Clare
EC
D035843:Biomedical Research / Q000639:trends*; D003880:Dermatology / Q000639:trends*; D004820:Epidermolysis Bullosa / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans