title: Transmission of hemagglutinin D222G mutant strain of pandemic (H1N1) 2009 virus.
abstract: A pandemic (H1N1) 2009 virus strain carrying the D222G mutation was identified in a severely ill man and was transmitted to a household contact. Only mild illness developed in the contact, despite his obesity and diabetes. The isolated virus reacted fully with an antiserum against the pandemic vaccine strain.
authors.affiliation: National Institute of Health, Rome, Italy. simona.puzelli@iss.it
authors.forename: Simona
authors.initials: S
authors.lastname: Puzelli
authors.forename: Marzia
authors.initials: M
authors.lastname: Facchini
authors.forename: Domenico
authors.initials: D
authors.lastname: Spagnolo
authors.forename: Maria A
authors.initials: MA
authors.lastname: De Marco
authors.forename: Laura
authors.initials: L
authors.lastname: Calzoletti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Zanetti
authors.forename: Roberto
authors.initials: R
authors.lastname: Fumagalli
authors.forename: Maria L
authors.initials: ML
authors.lastname: Tanzi
authors.forename: Antonio
authors.initials: A
authors.lastname: Cassone
authors.forename: Giovanni
authors.initials: G
authors.lastname: Rezza
authors.forename: Isabella
authors.initials: I
authors.lastname: Donatelli
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution; D004196:Disease Outbreaks; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics*; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics* / Q000302:isolation & purification; D007251:Influenza, Human / Q000453:epidemiology / Q000503:physiopathology / Q000635:transmission* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D010802:Phylogeny; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D012189:Retrospective Studies; D017423:Sequence Analysis, RNA; D012720:Severity of Illness Index
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus; D012367:RNA, Viral
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