Azetidinone-isothiazolidinones: stereoselective synthesis and antibacterial evaluation of new monocyclic beta-lactams.
A simple and efficient procedure for the stereoselective synthesis of new azetidinone-isothiazolidinones has been developed. New compounds were tested in vitro on a panel of Gram-positive and Gram-negative bacterial pathogens, some of them showing weak antibacterial activity.
Cerić
Helena
H
PLIVA Croatia Ltd, TAPI R&D, Chemical R&D, Prilaz baruna Filipovića 25, 10000 Zagreb, Croatia.
Sindler-Kulyk
Marija
M
Kovacević
Miće
M
Perić
Mihaela
M
Zivković
Andreja
A
D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001384:Azetidines / Q000737:chemistry*; D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D008997:Monobactams / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013237:Stereoisomerism; D053778:Thiazolidines / Q000737:chemistry*
C116379:2-azetidinone; D000900:Anti-Bacterial Agents; D001384:Azetidines; D008997:Monobactams; D053778:Thiazolidines; D000658:Amoxicillin