title: Synthesis and antitumor activity of bisindolylmaleimide and amino acid ester conjugates.
abstract: A series of novel bisindolylmaleimide and natural amino acid ester conjugates were synthesized and evaluated for their inhibitory activity against six tumor cell lines. Some compounds displayed interesting cytotoxic profiles. The most active compound 8e showed inhibitory activity against several human cancer cell lines.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine (Ministry of Education), Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Ke
authors.initials: K
authors.lastname: Wang
authors.forename: Xiang-Yan
authors.initials: XY
authors.lastname: Li
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Chen
authors.forename: Zhan-Zhu
authors.initials: ZZ
authors.lastname: Liu
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004952:Esters; D045325:HCT116 Cells; D019073:HT29 Cells; D056945:Hep G2 Cells; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D020014:K562 Cells; D008301:Maleimides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D019311:Staurosporine / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004952:Esters; D007211:Indoles; D008301:Maleimides; D019311:Staurosporine; C088060:bisindolylmaleimide