title: Cigarette smoking and mortality among HIV-infected individuals in Seattle, Washington (1996-2008).
abstract: HIV-infected individuals with access to highly active antiretroviral therapy (HAART) are living longer and the causes of excess morbidity and mortality among people living with HIV/AIDS (PLWHA) are becoming comparable to individuals without HIV infection. However, many PLWHA smoke cigarettes-a well known contributor to excess morbidity and mortality. To investigate the association between smoking and mortality among PLWHA during the HAART era (1996+), we conducted a retrospective cohort study of 2,108 PLWHA enrolled in Seattle and King County's Adult and Adolescent Spectrum of HIV Disease Study. Adjusted hazard ratios (aHRs) for all-cause and cause-specific mortality were obtained using Cox proportional hazards regression. Compared to never smokers, current smokers (aHR = 1.8, 95% CI: 1.3, 2.3) and individuals with an increased dose and/or duration of smoking were at greater risk of all-cause mortality. Although additional research is needed to evaluate the full effect of smoking on cause-specific mortality, smoking cessation programs should target PLWHA to further increase their life expectancy.
authors.affiliation: Department of Epidemiology, University of Washington,P.O. Box 357236, Seattle, WA 98195, USA. hpines@ucla.edu
authors.forename: Heather
authors.initials: H
authors.lastname: Pines
authors.forename: Laura
authors.initials: L
authors.lastname: Koutsky
authors.forename: Susan
authors.initials: S
authors.lastname: Buskin
mesh_terms: D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000401:mortality*; D006801:Humans; D008297:Male; D009026:Mortality / Q000639:trends; D012189:Retrospective Studies; D012306:Risk; D012907:Smoking / Q000401:mortality*; D014861:Washington / Q000453:epidemiology