title: New neuroprotective dibenzylbutane lignans isolated from Machilus thunbergii.
abstract: Two new dibenzylbutane lignans, namely rel-methyl (2S)-2-hydroxy-2-2'-((2''R,3''R)-4''-guaiacyl-2'',3''dimethylbutyl)-5'-oxo-2',5'-dihydro-2-furanylethnoate (1) and rel-methyl (2S)-2-hydroxy-2-2'-((2''R,3''S)-4''-guaiacyl-2'',3''dimethylbutyl)-5'-oxo-2',5'-dihydro-2-furanylethnoate (2), were isolated from the bark of Machilus thunbergii. Their structures were elucidated by spectral analysis. These two lignans exerted significant neuroprotective activities against glutamate-induced neurotoxicity in primary cultures of rat cortical cells. Compounds 1 and 2 represent a new type of lignan skeleton that has not been reported so far from nature.
authors.affiliation: School of Biotechnology and Bioengineering, Kangwon National University, Korea.
authors.forename: Choong Je
authors.initials: CJ
authors.lastname: Ma
authors.forename: Sang Hyun
authors.initials: SH
authors.lastname: Sung
authors.forename: Young Choong
authors.initials: YC
authors.lastname: Kim
mesh_terms: D000818:Animals; D001681:Biological Assay; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D005260:Female; D019770:Lauraceae / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification*; D018696:Neuroprotective Agents / Q000302:isolation & purification*; D024301:Plant Bark / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D017705:Lignans; D018696:Neuroprotective Agents