title: Developing and evaluating comprehensive HIV infection control strategies: issues and challenges.
abstract: As described elsewhere in this supplement, development of effective methods for prevention of human immunodeficiency virus (HIV) infection has proven to be more challenging than development of effective treatment for the disease. New strategies to control the HIV epidemic are urgently needed; this urgency creates interest in investigation of the possibility of using antiretroviral treatment in combination with other modalities to control the epidemic. This article summarizes current knowledge concerning prevention modalities in the context of the drivers of the HIV epidemic in specific communities, describes challenges in investigating test-and-treat strategies, and proposes research directions for addressing these challenges to investigate the impact of prevention strategies on mitigation of epidemics.
authors.affiliation: Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA. victor@sdac.harvard.edu
authors.forename: Victor
authors.initials: V
authors.lastname: DeGruttola
authors.forename: Davey M
authors.initials: DM
authors.lastname: Smith
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Little
authors.forename: Veronica
authors.initials: V
authors.lastname: Miller
mesh_terms: D003140:Communicable Disease Control / Q000379:methods*; D015658:HIV Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control*; D006302:Health Services Research / Q000379:methods*; D006801:Humans
references.citation: Reprod Health Matters. 2007 May;15(29):62-7
references.pmid: 17512377
references.citation: HIV Med. 2007 Sep;8(6):382-7
references.pmid: 17661846
references.citation: Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11236-40
references.pmid: 1763038
references.citation: J Virol. 2007 Dec;81(23):13050-6
references.pmid: 17898057
references.citation: PLoS One. 2008 May 21;3(5):e2212
references.pmid: 18493593
references.citation: AIDS. 2009 Jan 14;23(2):225-32
references.pmid: 19098493
references.citation: PLoS Med. 2009 Sep;6(9):e1000109
references.pmid: 19901974
references.citation: Am J Obstet Gynecol. 2007 Sep;197(3 Suppl):S42-55
references.pmid: 17825650
references.citation: Sex Transm Infect. 2002 Dec;78(6):448-51
references.pmid: 12473809
references.citation: Public Health Rep. 1998 Jun;113 Suppl 1:75-80
references.pmid: 9722812
references.citation: AIDS. 2006 Apr 4;20(6):923-8
references.pmid: 16549978
references.citation: Science. 1992 May 22;256(5060):1165-71
references.pmid: 1589796
references.citation: PLoS Clin Trials. 2007 May 25;2(5):e27
references.pmid: 17525796
references.citation: AIDS. 1997 Apr;11(5):641-8
references.pmid: 9108946
references.citation: J Infect Dis. 2005 May 1;191(9):1403-9
references.pmid: 15809897
references.citation: J Virol. 1997 Sep;71(9):6348-58
references.pmid: 9261352
references.citation: BMJ. 2009 Apr 30;338:b1649
references.pmid: 19406887
references.citation: N Engl J Med. 2008 Aug 28;359(9):888-90
references.pmid: 18753644
references.citation: Focus. 2007 May;22(5):1-4
references.pmid: 18333632
references.citation: Drug Alcohol Depend. 2009 Apr 1;101(1-2):101-6
references.pmid: 19117698
references.citation: Clin Infect Dis. 2010 May 15;50 Suppl 3:S85-95
references.pmid: 20397961
references.citation: AIDS. 2006 Mar 21;20(5):731-9
references.pmid: 16514304
references.citation: J Infect Dis. 2007 Apr 1;195(7):951-9
references.pmid: 17330784
references.citation: Curr Opin Infect Dis. 2006 Feb;19(1):1-7
references.pmid: 16374210
references.citation: AIDS Rev. 2006 Jul-Sep;8(3):125-40
references.pmid: 17078483
references.citation: Contemp Clin Trials. 2007 Feb;28(2):182-91
references.pmid: 16829207
references.citation: Lancet. 2007 Feb 24;369(9562):657-66
references.pmid: 17321311
references.citation: Curr Opin Infect Dis. 2008 Dec;21(6):644-52
references.pmid: 18978533
references.citation: Lancet. 2008 Jun 21;371(9630):2064-5
references.pmid: 18572064
references.citation: Science. 2004 Jan 16;303(5656):327-32
references.pmid: 14726583
references.citation: PLoS Med. 2005 Nov;2(11):e298
references.pmid: 16231970
references.citation: PLoS Med. 2006 Jul;3(7):e262
references.pmid: 16822094
references.citation: AIDS. 2008 Jul;22 Suppl 1:S67-74
references.pmid: 18664956
references.citation: J Int AIDS Soc. 2009 May 27;12:7
references.pmid: 19473540
references.citation: Am J Obstet Gynecol. 2007 Sep;197(3 Suppl):S26-32
references.pmid: 17825647
references.citation: N Engl J Med. 2005 Feb 10;352(6):570-85
references.pmid: 15703422
references.citation: Lancet. 2008 Sep 6;372(9641):831-44
references.pmid: 18687457
references.citation: Nature. 2006 Dec 14;444(7121):836-7
references.pmid: 17171825
references.citation: Cochrane Database Syst Rev. 2009 Jan 21;(1):CD007189
references.pmid: 19160329
references.citation: J Infect Dis. 2006 Jan 1;193(1):16-26
references.pmid: 16323127
references.citation: Am J Mens Health. 2008 Sep;2(3):291-5
references.pmid: 19477792
references.citation: J Immigr Minor Health. 2009 Feb;11(1):1-6
references.pmid: 18247117
references.citation: Curr HIV Res. 2009 May;7(3):279-86
references.pmid: 19442123
references.citation: AIDS Behav. 2009 Aug;13(4):615-29
references.pmid: 19205867
references.citation: Cochrane Database Syst Rev. 2008 Jul 16;(3):CD001230
references.pmid: 18646068
references.citation: Microbes Infect. 2003 Feb;5(2):189-96
references.pmid: 12650777
references.citation: J Acquir Immune Defic Syndr. 2004 Nov 1;37(3):1404-14
references.pmid: 15483470
references.citation: Cochrane Database Syst Rev. 2001;(3):CD003255
references.pmid: 11687062
references.citation: J Acquir Immune Defic Syndr. 2009 May 1;51 Suppl 1:S21-5
references.pmid: 19384097
references.citation: MMWR Morb Mortal Wkly Rep. 1994 May 20;43(19):347, 353-6
references.pmid: 8177193
references.citation: AIDS. 2009 Jun 19;23(10):1277-84
references.pmid: 19440142
references.citation: N Engl J Med. 2000 Mar 30;342(13):921-9
references.pmid: 10738050
references.citation: Sex Transm Dis. 2009 May;36(5):284-9
references.pmid: 19295472
references.citation: Lancet. 2007 Feb 24;369(9562):643-56
references.pmid: 17321310
references.citation: Stud Fam Plann. 2008 Dec;39(4):295-308
references.pmid: 19248716
references.citation: Science. 2001 May 11;292(5519):1106-9
references.pmid: 11352065
references.citation: J Exp Med. 2001 Jan 15;193(2):169-80
references.pmid: 11148221
references.citation: J R Soc Interface. 2005 Sep 22;2(4):295-307
references.pmid: 16849187
references.citation: PLoS Med. 2008 Mar 25;5(3):e71
references.pmid: 18366249
references.citation: Sex Transm Infect. 2009 Oct;85(6):420-6
references.pmid: 19188211
references.citation: PLoS Med. 2008 Mar 18;5(3):e50
references.pmid: 18351795
references.citation: J Acquir Immune Defic Syndr. 2009 Aug 15;51(5):593-600
references.pmid: 19421070
references.citation: BMJ. 2001 Nov 17;323(7322):1174-7
references.pmid: 11711413
references.citation: Am J Public Health. 2009 Jun;99(6):1093-9
references.pmid: 19372521