title: Graft selection for anterior cruciate ligament reconstruction: a level I systematic review comparing failure rates and functional outcomes.
abstract: Tear of the anterior cruciate ligament (ACL) is the most common ligamentous injury of the knee. Reconstructing this ligament is often required to restore functional stability of the knee. Many graft options are available for ACL reconstruction, including different autograft and allograft tissues. Autografts include bone-patellar tendon-bone composites (PT), combined semitendinosus and gracilis hamstring tendons (HT), and quadriceps tendon. Allograft options include the same types of tendons harvested from donors, in addition to Achilles and tibialis tendons. Tissue-engineered anterior cruciate grafts are not yet available for clinical use, but may become a feasible alternative in the future. The purpose of this systematic review is to assess whether one of the popular grafts (PT and HT) is preferable for reconstructing the ACL. For this objective, the authors selected only true level I studies that compared these graft choices in functional clinical outcomes, failure rates, and other objective parameters following reconstruction of the ACL. In addition, this review discusses mechanical considerations related to different allograft tissues.
authors.affiliation: reinhardtk@hss.edu
authors.forename: Keith R
authors.initials: KR
authors.lastname: Reinhardt
authors.forename: Iftach
authors.initials: I
authors.lastname: Hetsroni
authors.forename: Robert G
authors.initials: RG
authors.lastname: Marx
mesh_terms: D016118:Anterior Cruciate Ligament / Q000601:surgery*; D000070598:Anterior Cruciate Ligament Injuries; D050376:Bone-Patellar Tendon-Bone Grafting; D006801:Humans; D007718:Knee Injuries / Q000601:surgery*; D007719:Knee Joint / Q000503:physiopathology; D046788:Patellofemoral Pain Syndrome / Q000453:epidemiology; D011183:Postoperative Complications / Q000453:epidemiology; D016059:Range of Motion, Articular; D020127:Recovery of Function; D013710:Tendons / Q000637:transplantation*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D016896:Treatment Outcome