Joint analysis of structural and perfusion MRI for cognitive assessment and classification of Alzheimer's disease and normal aging.
Structural magnetic resonance imaging (MRI) of brain tissue loss and physiological imaging of regional cerebral blood flow (rCBF) can provide complimentary information for the characterization of brain disorders, such as Alzheimer's disease (AD) but studies into gains in classification power for AD using these image modalities jointly have been limited. Our aim in this study was to determine the joint contribution of structural and perfusion-weighted imaging for the classification of AD in a cross-sectional study using an integrated multimodality MRI processing framework and a cortical surface-based analysis approach. We used logistic regression analysis to determine sequentially the value of cortical thickness, rCBF, and cortical thickness and rCBF jointly for classification for diagnosis of AD compared to controls. We further tested the extent to which cortical thinning and reduced rCBF explain individually or together variability in dementia severity. Separate analysis of structural MRI and perfusion-weighted MRI data yielded the well-established pattern of cortical thinning and rCBF reduction in AD, affecting predominantly temporo-parietal brain regions. Using structural MRI and perfusion-weighted MRI jointly indicated that cortical thinning dominated the classification of AD and controls without significant contributions from rCBF. However there was also a positive interaction between reduced rCBF and cortical thinning in the right superior temporal sulcus, implying that structural and physiological brain alterations in AD can be complementary. Compared to reduced rCBF, regional cortical thinning better explained the variability in dementia severity. In conclusion, structural brain alterations compared to physiological variations are the dominant features of MRI in AD.
Tosun
Duygu
D
Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA. duygu.tosun@ucsf.edu
Mojabi
Pouria
P
Weiner
Michael W
MW
Schuff
Norbert
N
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology / Q000502:physiology; D000544:Alzheimer Disease / Q000473:pathology* / Q000503:physiopathology*; D001921:Brain / Q000098:blood supply / Q000473:pathology* / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000469:parasitology / Q000473:pathology / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D003071:Cognition / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D016015:Logistic Models; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012039:Regional Blood Flow; D012720:Severity of Illness Index; D012815:Signal Processing, Computer-Assisted
Rev Med Univ Navarra. 1997 Jan-Mar;41(1):12-8
9527710
Int J Geriatr Psychiatry. 2008 Nov;23(11):1114-8
18449954
Psychiatry Clin Neurosci. 2005 Jun;59(3):280-90
15896221
Neurology. 2008 Feb 12;70(7):512-20
17898323
Psychiatry Res. 2006 Apr 30;146(3):251-61
16524704
Arch Neurol. 1995 Mar;52(3):257-62
7872878
Q J Nucl Med Mol Imaging. 2007 Dec;51(4):357-63
17220817
Radiology. 2009 Mar;250(3):856-66
19164119
IEEE Trans Med Imaging. 1999 Oct;18(10):897-908
10628949
Alzheimers Dement. 2006 Jan;2(1):36-42
19595854
Neuroimage. 2008 Nov 15;43(3):458-69
18691658
J Psychiatr Res. 1975 Nov;12(3):189-98
1202204
Magn Reson Med. 1992 Jan;23(1):37-45
1734182
IEEE Trans Med Imaging. 2009 May;28(5):703-9
19150788
Neurology. 1989 Nov;39(11):1537-9
2812339
J Neuroimaging. 1995 Jul;5 Suppl 1:S45-52
7626837
Acta Neuropathol. 1991;82(4):239-59
1759558
Clin Exp Neurol. 1991;28:56-65
1821840
Brain. 2008 Sep;131(Pt 9):2455-63
18669506
Eur J Nucl Med Mol Imaging. 2002 Dec;29(12):1685-96
12458405
Clin Neurophysiol. 2005 Feb;116(2):364-75
15661114
Neurology. 2005 May 10;64(9):1520-4
15883311
Neuropsychologia. 2008;46(6):1597-612
18395760
Brain. 2002 Aug;125(Pt 8):1772-81
12135968
Neuroimage. 2008 Oct 15;43(1):59-68
18675918
Neurol Res. 2003 Sep;25(6):567-80
14503010
Med Image Anal. 2004 Sep;8(3):295-309
15450224
J Nucl Med. 1994 Feb;35(2):210-6
8294987
Radiology. 2005 Mar;234(3):851-9
15734937
Proc Natl Acad Sci U S A. 2002 Apr 2;99(7):4703-7
11930016
Int J Geriatr Psychiatry. 2003 Apr;18(4):288-91
12673603
IEEE Trans Med Imaging. 2003 Oct;22(10):1332-9
14552586
J Neurol Sci. 2008 Jan 15;264(1-2):27-33
17764699
Psychiatry Res. 2000 Dec 4;100(2):65-74
11114492
Med Phys. 2009 Aug;36(8):3737-47
19746807
Stat Med. 2000 Jun 15-30;19(11-12):1631-44
10844724
IEEE Trans Med Imaging. 2008 Dec;27(12):1739-53
19033090
Neuroimage. 2006 Feb 1;29(3):838-52
16269250
Dement Geriatr Cogn Disord. 2004;17(3):207-14
14739546
Neurology. 2005 Jun 14;64(11):1860-7
15955934
Neuroimage. 2004 Aug;22(4):1754-66
15275931
Neurology. 2006 Oct 10;67(7):1215-20
17030755
Hum Brain Mapp. 2009 Sep;30(9):2766-88
19172649
Neurology. 1998 Feb;50(2):380-3
9484357
Neuroimage. 2007 May 15;36(1):69-87
17408972
Neuroimage. 2008 Jul 1;41(3):835-48
18434199
Hum Brain Mapp. 2006 Jan;27(1):47-62
16108017
Brain. 2007 Jul;130(Pt 7):1777-86
17533169
Neurology. 2005 Aug 23;65(4):565-71
16116117
Arch Neurol. 2003 Aug;60(8):1066-72
12925361
Neurology. 2008 Sep 9;71(11):819-25
18672473
Nucl Med Commun. 2006 Jan;27(1):37-44
16340722
Brain. 2007 Mar;130(Pt 3):720-30
17293358
Neuroimage. 2006 Dec;33(4):1093-103
17011792
Neurology. 1994 Mar;44(3 Pt 1):454-61
8145915
J Neurol Neurosurg Psychiatry. 2003 Feb;74(2):208-12
12531952
Neuroimage. 2005 Mar;25(1):253-66
15734360
Neurobiol Aging. 2004 Oct;25(9):1197-203
15312965
Neuroimage. 2008 Oct 1;42(4):1267-74
18602481
Eur J Nucl Med Mol Imaging. 2002 Jul;29(7):899-906
12111130
Psychiatr Pol. 2005 Sep-Oct;39(5):977-86
16358596
Proc Natl Acad Sci U S A. 2005 Jun 7;102(23):8299-302
15932949
Eur J Nucl Med Mol Imaging. 2006 Jul;33(7):801-9
16550383
J Neuropsychiatry Clin Neurosci. 1997 Winter;9(1):68-74
9017531
J Neurosci. 2003 Feb 1;23(3):994-1005
12574429
Br J Psychiatry. 1989 Jun;154:790-6
2557110
J Nucl Med. 1995 Apr;36(4):690-6
7699466
Neuroimage. 2009 Mar;45(1 Suppl):S3-15
19041724
Neuroimage. 2008 Jun;41(2):277-85
18400519
Neuroimage. 2008 May 15;41(1):19-34
18378167
Brain Cogn. 1996 Dec;32(3):365-83
8975677
J Psychiatry Neurosci. 2008 May;33(3):218-26
18592038
J Gerontol A Biol Sci Med Sci. 2006 Mar;61(3):267-71
16567376
Magn Reson Imaging. 1997;15(10):1133-43
9408134
Hippocampus. 2005;15(4):535-50
15884035
J Nucl Med. 1996 Jul;37(7):1159-65
8965188
Eur J Nucl Med Mol Imaging. 2004 Jul;31(7):975-80
14991240
Am J Physiol Imaging. 1989;4(3):89-96
2789844
Med Image Comput Comput Assist Interv. 2005;8(Pt 2):411-8
16685986
Neuroimage. 2009 Jan 1;44(1):43-50
18691659
Dement Geriatr Cogn Disord. 1999 Nov-Dec;10(6):511-7
10559568
Neurology. 2004 Feb 24;62(4):591-600
14981176
Eur J Radiol. 1999 May;30(2):115-24
10401592
J Clin Epidemiol. 1995 Apr;48(4):473-83
7722601
Neuroimage. 2003 Feb;18(2):525-41
12595205
J Cereb Blood Flow Metab. 2008 Apr;28(4):725-36
17960142
Nihon Ronen Igakkai Zasshi. 1997 Jun;34(6):468-73
9301261
J Cogn Neurosci. 2000 Jan;12(1):1-47
10769304
J Neurol Neurosurg Psychiatry. 1992 Dec;55(12):1182-7
1479398
Dement Geriatr Cogn Disord. 2001 Mar-Apr;12(2):153-7
11173889
J Nucl Med. 2002 Jan;43(1):21-6
11801698
J Nucl Med. 1999 Apr;40(4):522-9
10210209
Neuroimage. 2006 Apr 15;30(3):768-79
16412666
Neuroimage. 2004 Nov;23(3):997-1012
15528100
J Nucl Med. 2007 Dec;48(12):1961-70
18006622
Neuroimage. 2009 Oct 1;47(4):1196-206
19463961
IEEE Trans Med Imaging. 1999 Oct;18(10):885-96
10628948
Alzheimer Dis Assoc Disord. 2004 Oct-Dec;18(4):196-201
15592130