title: [Comparison of hemogram changes under chronic intermittent hypoxia in Lasiopodomys mandarinus and Kunming Mus musculus].
abstract: Mandarin vole (Lasiopodomys mandarinus) spends almost all of its life underground and must have evolved remarkable adaptations to cope with the subterranean hypoxic stress. The aim of present study is to explore the adaptation mechanism through the comparison of hemogram changes under chronic intermittent hypoxia in Mandarin vole and Kunming (KM) mouse (Mus musculus). Mandarin vole and KM mouse were treated with chronic intermittent hypoxia (10.0% oxygen), which was maintained by an oxygen cabin, for 4 h per day during four weeks. Then blood samples from the animals with and without hypoxia treatment were analyzed by a hematology analyzer. The results showed that under normoxic condition mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), white blood cell count (WBC) and platelet (PLT) in Mandarin vole were significantly lower than those in KM mouse. On the contrast, red blood cell count (RBC) and mean corpuscular hemoglobin concentration (MCHC) in Mandarin vole were higher than that in KM mouse. After four-week chronic intermittent hypoxia treatment, the hemogram changes were as following. MCV and HCT were elevated in Mandarin vole, not affected in KM mouse. Both hemoglobin (HGB) content and MCH in KM mouse increased, while only MCH increased in Mandarin vole. No obvious changes of WBC and PLT were found in two species. These results suggest that the adaptive mechanism of blood system in Mandarin vole responding to hypoxic conditions is different from that of KM mouse. As a subterranean vole, the Mandarin vole has a better tolerance to hypoxia.
authors.affiliation: Institute of Biodiversity and Ecology, Zhengzhou University, Zhengzhou 450001, China.
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Zhen-Long
authors.initials: ZL
authors.lastname: Wang
authors.forename: Ji-Qi
authors.initials: JQ
authors.lastname: Lu
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Yang
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000818:Animals; D003411:Arvicolinae / Q000097:blood*; D002908:Chronic Disease; D004912:Erythrocytes; D006454:Hemoglobins; D000860:Hypoxia / Q000097:blood*; D051379:Mice / Q000097:blood*; D013045:Species Specificity
chemical_list: D006454:Hemoglobins