The emergence of oseltamivir-resistant pandemic influenza A (H1N1) 2009 virus amongst hospitalised immunocompromised patients in Scotland, November-December, 2009.
To investigate the frequency of oseltamivir resistance in circulating strains of the 2009 influenza A(H1N1) pandemic virus in Scotland, 1,802 samples from 1,608 infected hospitalised patients were screened by the H275Y discriminatory RT-PCR. Among these, we identified 10 patients who developed the H275Y mutation. All of them were immunocompromised and were under treatment or had been treated previously with oseltamivir.
Harvala
H
H
Specialist Virology Centre, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom. heli.harvala@luht.scot.nhs.uk
Gunson
R
R
Simmonds
P
P
Hardie
A
A
Bennett
S
S
Scott
F
F
Roddie
H
H
McKnight
J
J
Walsh
T
T
Rowney
D
D
Clark
A
A
Bremner
J
J
Aitken
C
C
Templeton
K
K
D024882:Drug Resistance, Viral / Q000235:genetics*; D005500:Follow-Up Studies; D006760:Hospitalization / Q000639:trends*; D006801:Humans; D016867:Immunocompromised Host / Q000187:drug effects / Q000235:genetics*; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics*; D007251:Influenza, Human / Q000188:drug therapy / Q000235:genetics*; D053139:Oseltamivir / Q000627:therapeutic use*; D058873:Pandemics; D012606:Scotland / Q000453:epidemiology
D053139:Oseltamivir