Paraoxonase 1 (PON1) polymorphisms and risk for migraine.
The polymorphic enzyme human serum paraoxonase 1 (PON1), encoded by the gene PON1 (chromosome 7q21.3) plays a role as an antioxidant molecule through several mechanisms. Because oxidative stress has been implicated in the pathogenesis of migraine, we have investigated the possible association between the nonsynonymous polymorphisms 55LM and 192QR in the PON1 and the risk for migraine. We studied the frequency of the PON1 genotypes and allelic variants in 197 patients with migraine and 220 healthy controls using a TaqMan single nucleotide polymorphism analysis. The frequencies of the PON1 genotypes and PON1 allelic variants did not differ significantly between patients with migraine and controls, and were unrelated with gender, family history of migraine, and presence or absence of aura. The frequencies of the genotype PON1 192QQ and the allelic variant PON1 192Q were significantly higher in patients with earlier onset of migraine. The results of the present study suggest that PON1 polymorphisms are not related with the risk for migraine in Caucasian Spanish people, although PON1 192Q/Q genotype and PON1 192Q allelic variant should be related with an earlier onset of migraine.
García-Martín
Elena
E
Department of Biochemistry and Molecular Biology, School of Biological Sciences, University of Extremadura, Badajoz, Spain.
Martínez
Carmen
C
Serrador
Mercedes
M
Alonso-Navarro
Hortensia
H
Navacerrada
Francisco
F
Agúndez
José A G
JA
Jiménez-Jiménez
Félix Javier
FJ
D000328:Adult; D043303:Aryldialkylphosphatase / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000201:enzymology* / Q000453:epidemiology / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012307:Risk Factors
D043303:Aryldialkylphosphatase; C468406:PON1 protein, human
Cephalalgia. 2004 Jul;24(7):528-32
15196294
Nat Genet. 2003 Feb;33(2):192-6
12539047
Psychiatr Genet. 2008 Dec;18(6):289-94
19018234
Cephalalgia. 1997 Aug;17(5):580-4
9251872
Lancet. 2005 Jul 30-Aug 5;366(9483):371-7
16054936
Cephalalgia. 2007 Oct;27(10):1136-41
17725652
Cephalalgia. 2005 May;25(5):353-8
15839850
Cephalalgia. 1994 Jun;14(3):215-8; discussion 181
7954742
Cephalalgia. 2004 Jan;24(1):37-43
14687011
Nat Genet. 1993 Jan;3(1):73-6
8098250
Curr Opin Lipidol. 2002 Aug;13(4):357-62
12151850
Cephalalgia. 2003 Feb;23(1):39-42
12534579
Biol Trace Elem Res. 2008 Winter;126(1-3):92-7
18690416
Tohoku J Exp Med. 2007 Jan;211(1):23-30
17202769
Atherosclerosis. 1998 Aug;139(2):341-9
9712341
Curr Opin Lipidol. 1996 Apr;7(2):69-76
8743898
J Mol Med (Berl). 2003 Dec;81(12):766-79
14551701
Cardiovasc Pathol. 2008 Jul-Aug;17(4):226-32
18402813
Cell. 1996 Nov 1;87(3):543-52
8898206
Am J Hum Genet. 1993 Mar;52(3):598-608
7916578
BMJ. 1995 Aug 26;311(7004):541-4
7663209
Pharmacol Rep. 2008 Jul-Aug;60(4):542-8
18799823
Toxicol Appl Pharmacol. 2001 May 15;173(1):1-6
11350209