title: Mechanistic electronic model to simulate and predict the effect of heat stress on the functional genomics of HO-1 system: Vasodilation.
abstract: The present work is concerned to model the molecular signalling pathway for vasodilation and to predict the resting young human forearm blood flow under heat stress. The mechanistic electronic modelling technique has been designed and implemented using MULTISIM 8.0 and an assumption of 1V/ degrees C for prediction of forearm blood flow and the digital logic has been used to design the molecular signalling pathway for vasodilation. The minimum forearm blood flow has been observed at 35 degrees C (0 ml 100 ml(-1)min(-1)) and the maximum at 42 degrees C (18.7 ml 100 ml(-1)min(-1)) environmental temperature with respect to the base value of 2 ml 100 ml(-1)min(-1). This model may also enable to identify many therapeutic targets that can be used in the treatment of inflammations and disorders due to heat-related illnesses.
authors.affiliation: Department of Biomedical Instrumentation, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, India. yogenderaggarwal@gmail.com <yogenderaggarwal@gmail.com>
authors.forename: Yogender
authors.initials: Y
authors.lastname: Aggarwal
authors.forename: Bhuwan Mohan
authors.initials: BM
authors.lastname: Karan
authors.forename: Barda Nand
authors.initials: BN
authors.lastname: Das
authors.forename: Rakesh Kumar
authors.initials: RK
authors.lastname: Sinha
mesh_terms: D000818:Animals; D040761:Biomimetic Materials; D001783:Blood Flow Velocity / Q000502:physiology; D003198:Computer Simulation; D004581:Electronics; D005542:Forearm / Q000098:blood supply* / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000378:metabolism*; D018869:Heat-Shock Response / Q000502:physiology*; D051547:Heme Oxygenase-1 / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D020543:Proteome / Q000378:metabolism; D014664:Vasodilation / Q000502:physiology*
chemical_list: D006360:Heat-Shock Proteins; D020543:Proteome; C496541:HMOX1 protein, human; D051547:Heme Oxygenase-1