Regulatory mechanisms for apoptosis in placental tissue during normal pregnancy and gestosis-complicated pregnancy.
The localization of apoptosis and expression of proapoptotic and antiapoptotic factors by the placental tissue were compared during normal pregnancy and gestosis-complicated pregnancy. The degree of apoptosis did not differ in the third trimester of normal pregnancy and gestosis-complicated pregnancy. Increased expression of Fas, caspase-8, and caspase-3 in placental tissue during normal pregnancy was shown to contribute to the suppression of angiogenesis and growth of placental tissue. No differences were found in the expression of FasL (CD95L), caspase-2, caspase-9, and Mcl-1 by placental cells during normal pregnancy and gestosis-complicated pregnancy. Increased expression of TRAIL by trophoblast cells is a protective mechanism from apoptotic signals of maternal cytotoxic lymphocytes and NK cells during gestosis.
Sokolov
D I
DI
DO Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St Petersburg, Russia. corbie@hotmail.ru
Kolobov
A V
AV
Lesnichija
M V
MV
Kostiouchek
I N
IN
Stepanova
O I
OI
Kvetnoy
I M
IM
Selkov
S A
SA
D017209:Apoptosis / Q000502:physiology*; D015415:Biomarkers / Q000378:metabolism; D053143:Caspase 2 / Q000378:metabolism; D053453:Caspase 9 / Q000378:metabolism; D053222:Fas Ligand Protein / Q000378:metabolism; D005260:Female; D005865:Gestational Age; D006801:Humans; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D010920:Placenta / Q000473:pathology / Q000502:physiology; D011225:Pre-Eclampsia / Q000473:pathology / Q000503:physiopathology; D011247:Pregnancy; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism
D015415:Biomarkers; D053222:Fas Ligand Protein; D064549:Myeloid Cell Leukemia Sequence 1 Protein; D019253:Proto-Oncogene Proteins c-bcl-2; D053143:Caspase 2; D053453:Caspase 9