title: Utahmycins a and B, azaquinones produced by an environmental DNA clone.
abstract: Two new azaquinones, utahmycins A (1) and B (2), were isolated from cultures of Streptomyces albus J1704 transformed with the environmental DNA-derived Erd gene cluster. The structures of 1 and 2 were elucidated by spectroscopic analyses. The structure of 1 was confirmed by single-crystal X-ray diffraction analysis. Both metabolites appear to arise from the addition of a nitrogen atom to erdacin biosynthetic intermediates. Utahmycin A (1) is the first example of a biologically derived 1,3-dimethyl-2-azaanthraquinone.
authors.affiliation: Laboratory of Genetically Encoded Small Molecules, Howard Hughes Medical Institute, The Rockefeller University, New York, New York 10065, USA.
authors.forename: John D
authors.initials: JD
authors.lastname: Bauer
authors.forename: Ryan W
authors.initials: RW
authors.lastname: King
authors.forename: Sean F
authors.initials: SF
authors.lastname: Brady
mesh_terms: D018360:Crystallography, X-Ray; D004247:DNA; D008968:Molecular Conformation; D015394:Molecular Structure; D030781:Organisms, Genetically Modified; D011809:Quinones / Q000737:chemistry / Q000302:isolation & purification*; D013302:Streptomyces / Q000737:chemistry* / Q000235:genetics
chemical_list: D011809:Quinones; C550044:utahmycin A; C550043:utahmycin B; D004247:DNA
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