title: Imaging diagnosis--Neuronal ceroid lipofuscinosis with a chronic subdural hematoma.
abstract: A subdural hematoma was found to accompany neuronal ceroid lipofuscinosis in an 11-month-old Dachshund. Results from clinical, magnetic resonance (MR) imaging, histopathologic, ultrastructural, and molecular assessments are described. The dog had a 3-month history of progressive neurologic signs. In MR images, there was severe asymmetric cerebral atrophy with a subdural hematoma. Histopathologically, there was autofluorescent, periodic acid-Schiff-positive lipopigment in neurons and transmission electron microscopy confirmed a typical curvilinear profile of the storage bodies. We hypothesize that rapid brain atrophy contributed to the subdural hematoma formation, a complication not described previously in dogs with neuronal lipofuscinosis.
authors.affiliation: Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA. midori_asakawa@ncsu.edu
authors.forename: Midori Goto
authors.initials: MG
authors.lastname: Asakawa
authors.forename: Edward
authors.initials: E
authors.lastname: MacKillop
authors.forename: Natasha J
authors.initials: NJ
authors.lastname: Olby
authors.forename: Ian D
authors.initials: ID
authors.lastname: Robertson
authors.forename: John M
authors.initials: JM
authors.lastname: Cullen
mesh_terms: D000818:Animals; D001344:Autopsy / Q000662:veterinary; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D004283:Dog Diseases / Q000175:diagnosis* / Q000209:etiology; D004285:Dogs; D037901:Euthanasia, Animal; D020200:Hematoma, Subdural, Chronic / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D008279:Magnetic Resonance Imaging / Q000662:veterinary*; D008297:Male; D009472:Neuronal Ceroid-Lipofuscinoses / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D011859:Radiography