Regulatory T cells: immune suppression and beyond.
Foxp3-expressing regulatory T cells (Tregs) were originally identified as critical in maintaining self-tolerance and immune homeostasis. The immunosuppressive functions of Tregs are widely acknowledged and have been extensively studied. Recent studies have revealed many diverse roles of Tregs in shaping the immune system and the inflammatory response. This review will discuss our efforts as well as the efforts of others towards understanding the multifaceted function of Tregs in immune regulation.
Wan
Yisong Y
YY
Lineberger Comprehensive Cancer Center, Department of Microbiology and Immunology, The University of North Carolina at Chapel Hill, School of Medicine, North Carolina, NC 27599-7295, USA. wany@email.unc.edu
D000818:Animals; D006706:Homeostasis; D006801:Humans; D007108:Immune Tolerance; D007249:Inflammation / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
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