Imaging breast cancer chemotherapy response with light. Commentary on Soliman et al., p. 2605.
Diffuse optical spectroscopy (DOS), which is used to image tumor metabolic response to neoadjuvant chemotherapy (NAC), shows large changes in tumor functional parameters with significant reductions in oxy- and deoxyhemoglobin for responders versus nonresponders. Although investigational, DOS may provide a cost-effective, risk-free method for optimizing NAC drug and dosing strategies for individual patients.
Tromberg
Bruce J
BJ
Laser Microbeam and Medical Program, Beckman Laser Institute and Medical Clinic, University of California, Irvine, CA 92715, USA. bjtrombe@uci.edu
Cerussi
Albert E
AE
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D003952:Diagnostic Imaging / Q000379:methods*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D010108:Oxyhemoglobins / Q000378:metabolism; D011379:Prognosis; D015203:Reproducibility of Results; D013997:Time Factors; D016896:Treatment Outcome
D006454:Hemoglobins; D010108:Oxyhemoglobins; C100003:deoxyhemoglobin
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