title: Prevalence and functional impact of lipomatous metaplasia in scar tissue following myocardial infarction evaluated by MRI.
abstract: OBJECTIVE
  To retrospectively assess the prevalence and functional relevance of lipomatous metaplasia (LM) of the left ventricle in patients with chronic ischaemic heart disease (CIHD) using cardiac magnetic resonance imaging (cMRI) with steady state free precession (SSFP) sequences.
  
  
  METHODS
  We examined 315 patients (248 male, mean age 63 +/- 10 years) with a history of CIHD by cMRI. Standard SSFP sequences were applied and results were correlated with findings from cardiac catheterisation and computed tomography. In a subgroup of patients with LM (LM+) the functional results were correlated with patients without LM (LM-) as controls matched for age, body mass index, gender and infarct size.
  
  
  RESULTS
  Of 315 patients, 36 showed LM. LM+ patients showed a higher tendency to develop aneurysms compared with LM- (31% vs. 17%; not significant), but no differences in ejection fraction or volumetric parameters. LM occurred significantly more often in older infarcts and patients with hyperlipoproteinaemia, while other cardiac risk factors or medication did not have a significant influence on the development of LM.
  
  
  CONCLUSIONS
  LM is a common finding (11%) in patients with CIHD. LM does not have a significant influence on global cardiac function or ventricular size, but on local function and probably also on the development of left ventricular aneurysms.
authors.affiliation: Department of Diagnostic and Interventional Radiology, Leipzig Heart Center/University of Leipzig, Strümpellstr. 39, 04289, Leipzig, Germany. christian.luecke@herzzentrum-leipzig.de
authors.forename: Christian
authors.initials: C
authors.lastname: Lücke
authors.forename: Kathrin
authors.initials: K
authors.lastname: Schindler
authors.forename: Lukas
authors.initials: L
authors.lastname: Lehmkuhl
authors.forename: Matthias
authors.initials: M
authors.lastname: Grothoff
authors.forename: Ingo
authors.initials: I
authors.lastname: Eitel
authors.forename: Gerhard
authors.initials: G
authors.lastname: Schuler
authors.forename: Holger
authors.initials: H
authors.lastname: Thiele
authors.forename: Dietmar
authors.initials: D
authors.lastname: Kivelitz
authors.forename: Matthias
authors.initials: M
authors.lastname: Gutberlet
mesh_terms: D002921:Cicatrix / Q000175:diagnosis* / Q000453:epidemiology*; D015897:Comorbidity; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D008068:Lipomatosis / Q000453:epidemiology* / Q000473:pathology*; D019028:Magnetic Resonance Imaging, Cine / Q000706:statistics & numerical data*; D008297:Male; D008679:Metaplasia / Q000453:epidemiology / Q000473:pathology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000453:epidemiology*; D015995:Prevalence; D015203:Reproducibility of Results; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000453:epidemiology
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