Reduced expression of PTEN protein and its prognostic significance in the gastrointestinal stromal tumor.
Little is reported about the role of PTEN gene in the progression and prognosis of GISTs. This study examined the clinical implications of the tumor suppressor gene PTEN as a prognostic factor in the GISTs. Immunohistological staining and immunoblotting were employed to examine the PTEN protein expression, and its association with clinical measures. Clinicopathological features were reviewed by a retrospective examination of medical records. Reduced PTEN expression was significantly associated with tumor diameter, mitotic figure count, metastasis and pathological stage of tumor (P<0.05), and was not correlated with age, gender and tumor location (P>0.05). The 3-year survival rate of the patients with reduced PTEN expression was significantly lower than those with high PTEN expression (P<0.01). These results suggest that the expression of PTEN gene was significantly linked with the progression and metastasis of GISTs and it is an independent prognostic factor.
Zhang
Yonghong
Y
Tongji Cancer Research Institute, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. yonghong_zhang@qq.com
Yu
Dongdong
D
Li
Xiaolan
X
Hu
Junbo
J
Gong
Jianping
J
D000368:Aged; D015536:Down-Regulation; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000378:metabolism*; D046152:Gastrointestinal Stromal Tumors / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D051059:PTEN Phosphohydrolase / Q000378:metabolism*; D011379:Prognosis
D051059:PTEN Phosphohydrolase; C494929:PTEN protein, human
Clin Cancer Res. 2007 Sep 15;13(18 Pt 1):5398-405
17875769
Cancer Res. 1999 Jan 15;59(2):442-9
9927060
J Clin Oncol. 2008 Nov 20;26(33):5352-9
18955458
Dev Biol. 2004 Sep 15;273(2):175-84
15328005
Science. 2003 Jan 31;299(5607):708-10
12522257
Proc Natl Acad Sci U S A. 1999 Mar 2;96(5):2110-5
10051603
Histopathology. 2008 Sep;53(3):245-66
18312355
Am J Surg Pathol. 1983 Sep;7(6):507-19
6625048
Hum Pathol. 2002 May;33(5):459-65
12094370
Expert Opin Pharmacother. 2003 Jun;4(6):869-74
12783584
Cell. 2000 Feb 18;100(4):387-90
10693755
Cancer Res. 2001 Jun 1;61(11):4569-75
11389092
Semin Cell Dev Biol. 2004 Apr;15(2):171-6
15209376
Hum Pathol. 2002 May;33(5):484-95
12094373
Hum Pathol. 2002 May;33(5):466-77
12094371
Science. 1998 Jan 23;279(5350):577-80
9438854
Cancer Res. 1997 Sep 1;57(17):3657-9
9288766
Hum Pathol. 2001 Jun;32(6):578-82
11431711
Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15406-11
9860981
Biochem J. 2004 Aug 15;382(Pt 1):1-11
15193142
Cancer Res. 2001 Nov 15;61(22):8118-21
11719439
Virchows Arch. 2001 Jan;438(1):1-12
11213830
Curr Genomics. 2006;7(8):469-75
18369405
Cancer Res. 1997 Dec 1;57(23):5221-5
9393738
Am J Gastroenterol. 2005 Jan;100(1):162-8
15654796