ACTH is a novel regulator of bone mass.
Adrenocorticotropin (ACTH) is one of several peptide hormones derived from a larger molecule, proopiomelanocortin (POMC). ACTH is a classic endocrine hormone, processed and secreted from the pituitary to stimulate cortisol production from the fasciculata cells in the adrenal gland. However, ACTH is also produced by other cells, including macrophages, at many sites in the body. ACTH binds to a specific member of the melanocortin receptor family, the MC2R. MC2R is expressed in osteoblastic cells in vivo, as shown by in situ hybridization. MC2R expression is strongest at sites of active bone deposition, and thus ACTH response probably varies with osteoblastic activity or stage of osteoblast differentiation. In vitro ACTH stimulates proliferation of osteoblasts in a dose-dependent manner. ACTH at 10 nM increases collagen I mRNA in the osteoblastic cell line SaOs2, although at lower concentrations ACTH may oppose osteoblast differentiation. ACTH is thus, at high concentrations, anabolic for the osteoblast, and it is highly likely that the hormone has concentration-dependent effects on bone metabolism in vivo.
Isales
Carlos M
CM
Department of Orthopaedic Surgery, Medical College of Georgia, Augusta, Georgia, USA. cisales@mcg.edu
Zaidi
Mone
M
Blair
Harry C
HC
D000324:Adrenocorticotropic Hormone / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D015519:Bone Density / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D001842:Bone and Bones / Q000033:anatomy & histology* / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009929:Organ Size / Q000187:drug effects / Q000235:genetics; D019899:Paracrine Communication / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D010907:Pituitary Hormones / Q000494:pharmacology / Q000502:physiology; D018043:Receptors, Corticotropin / Q000235:genetics / Q000378:metabolism / Q000502:physiology
D010907:Pituitary Hormones; D018043:Receptors, Corticotropin; D000324:Adrenocorticotropic Hormone