title: Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention.
abstract: Tobacco carcinogen and toxicant biomarkers are metabolites or protein or DNA adducts of specific compounds in tobacco products. Highly reliable analytical methods, based mainly on mass spectrometry, have been developed and applied in large studies of many of these biomarkers. A panel of tobacco carcinogen and toxicant biomarkers is suggested here, and typical values for smokers and nonsmokers are summarized. This panel of biomarkers has potential applications in the new and challenging area of tobacco product regulation and in the development of rational approaches to cancer prevention by establishing carcinogen and toxicant uptake and excretion in people exposed to tobacco products.
authors.affiliation: Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street SE, Minneapolis, Minnesota 55455, USA. hecht002@umn.edu
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Hecht
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Yuan
authors.forename: Dorothy
authors.initials: D
authors.lastname: Hatsukami
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis / Q000378:metabolism*; D002273:Carcinogens / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000209:etiology / Q000517:prevention & control*; D012907:Smoking / Q000331:legislation & jurisprudence / Q000378:metabolism*; D062789:Tobacco Products
chemical_list: D014408:Biomarkers, Tumor; D002273:Carcinogens
references.citation: Chem Res Toxicol. 1998 Jun;11(6):559-603
references.pmid: 9625726
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):693-8
references.pmid: 15767351
references.citation: Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1184-8
references.pmid: 16775179
references.citation: Biomarkers. 2009 Dec;14(8):547-53
references.pmid: 19747086
references.citation: Nicotine Tob Res. 2009 Oct;11(10):1216-25
references.pmid: 19700523
references.citation: Biomarkers. 2006 May-Jun;11(3):201-20
references.pmid: 16760130
references.citation: Br J Cancer. 2008 Jan 29;98(2):270-6
references.pmid: 18087271
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3334-48
references.pmid: 19959680
references.citation: Circulation. 1996 Jul 1;94(1):19-25
references.pmid: 8964113
references.citation: Cancer Res. 2008 Nov 15;68(22):9137-40
references.pmid: 19010884
references.citation: MMWR Morb Mortal Wkly Rep. 2009 Nov 13;58(44):1232-5
references.pmid: 19910910
references.citation: Nicotine Tob Res. 2005 Oct;7(5):729-38
references.pmid: 16191744
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3143-95
references.pmid: 19959672
references.citation: BMJ. 2004 Jan 10;328(7431):72
references.pmid: 14715602
references.citation: Nature. 2008 Apr 3;452(7187):633-7
references.pmid: 18385738
references.citation: Regul Toxicol Pharmacol. 2007 Mar;47(2):171-83
references.pmid: 17034917
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Apr 15;877(11-12):1185-92
references.pmid: 19328751
references.citation: Cancer Epidemiol Biomarkers Prev. 2008 Jul;17(7):1764-73
references.pmid: 18628430
references.citation: Int J Cancer. 2003 May 1;104(5):650-7
references.pmid: 12594823
references.citation: Arterioscler Thromb Vasc Biol. 2005 Feb;25(2):279-86
references.pmid: 15591226
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Mar;18(3):884-93
references.pmid: 19258471
references.citation: J Clin Pharmacol. 2007 Apr;47(4):518-30
references.pmid: 17389561
references.citation: Cancer Prev Res (Phila). 2008 Sep;1(4):250-4
references.pmid: 19138968
references.citation: J Natl Cancer Inst. 2003 Mar 19;95(6):470-8
references.pmid: 12644540
references.citation: MMWR Morb Mortal Wkly Rep. 2008 Jul 11;57(27):744-7
references.pmid: 18614993
references.citation: Chem Res Toxicol. 2009 Jun;22(6):1018-25
references.pmid: 19522547
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3305-20
references.pmid: 19959678
references.citation: Cancer Res. 1999 Feb 1;59(3):590-6
references.pmid: 9973205
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Jun;14(6):1376-83
references.pmid: 15941944
references.citation: Lancet Oncol. 2005 Dec;6(12):931-2
references.pmid: 16353404
references.citation: Chem Res Toxicol. 2009 Apr;22(4):734-41
references.pmid: 19317515
references.citation: Nat Rev Cancer. 2003 Oct;3(10):733-44
references.pmid: 14570033
references.citation: Inhal Toxicol. 2006 Sep;18(10):821-9
references.pmid: 16774872
references.citation: Tob Control. 2004 Mar;13 Suppl 1:i48-56
references.pmid: 14985617
references.citation: J Natl Cancer Inst. 2007 May 2;99(9):715-26
references.pmid: 17470739
references.citation: Cancer Res. 2009 Apr 1;69(7):2990-5
references.pmid: 19318550
references.citation: Biomarkers. 2006 Jan-Feb;11(1):28-52
references.pmid: 16484135
references.citation: Exp Toxicol Pathol. 2005 Jul;57 Suppl 1:75-110
references.pmid: 16092718
references.citation: Tob Control. 2008 Apr;17(2):132-41
references.pmid: 18375736
references.citation: Hum Exp Toxicol. 2007 Jan;26(1):37-47
references.pmid: 17334178
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Dec;18(12):3421-5
references.pmid: 19959691
references.citation: Nicotine Tob Res. 2006 Aug;8(4):600-22
references.pmid: 16920658
references.citation: Hum Exp Toxicol. 1997 Aug;16(8):449-59
references.pmid: 9292285
references.citation: J Anal Toxicol. 2009 Jun;33(5):260-5
references.pmid: 19671245
references.citation: Nicotine Tob Res. 2008 Dec;10(12):1761-72
references.pmid: 19023827
references.citation: Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):885-91
references.pmid: 15824160
references.citation: N Engl J Med. 1993 Nov 18;329(21):1543-6
references.pmid: 8413477
references.citation: Nat Genet. 2008 May;40(5):616-22
references.pmid: 18385676
references.citation: Cancer Epidemiol Biomarkers Prev. 2008 Mar;17(3):732-5
references.pmid: 18349296
references.citation: IARC Monogr Eval Carcinog Risks Hum. 2004;83:1-1438
references.pmid: 15285078
references.citation: Cancer Epidemiol Biomarkers Prev. 2007 Jul;16(7):1408-15
references.pmid: 17627005
references.citation: Chem Res Toxicol. 2008 Dec;21(12):2245-56
references.pmid: 19548348
references.citation: Cancer Res. 2009 Sep 15;69(18):7170-4
references.pmid: 19738046
references.citation: IARC Monogr Eval Carcinog Risks Hum. 2007;89:1-592
references.pmid: 18335640
references.citation: J Lipid Res. 2007 Jul;48(7):1607-17
references.pmid: 17456897
references.citation: IARC Monogr Eval Carcinog Risks Hum. 2008;97:3-471
references.pmid: 20232717
references.citation: Chem Res Toxicol. 2008 Jan;21(1):160-71
references.pmid: 18052103
references.citation: Regul Toxicol Pharmacol. 2008 Aug;51(3):295-305
references.pmid: 18565634
references.citation: Thromb Res. 2000 Aug 1;99(3):209-21
references.pmid: 10944241
references.citation: Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):260-6
references.pmid: 19124507
references.citation: Lancet Oncol. 2009 Nov;10(11):1033-4
references.pmid: 19891056
references.citation: Int J Hyg Environ Health. 2006 Jul;209(4):359-66
references.pmid: 16740414
references.citation: Int J Hyg Environ Health. 2008 Oct;211(5-6):471-503
references.pmid: 18222724
references.citation: Cancer Prev Res (Phila). 2009 Apr;2(4):322-9
references.pmid: 19336727
references.citation: IARC Monogr Eval Carcinog Risks Hum. 1999;71 Pt 1, Pt 2, Pt 3:1-1554
references.pmid: 10507919
references.citation: Arch Environ Contam Toxicol. 2000 Apr;38(3):377-83
references.pmid: 10667937
references.citation: J Expo Anal Environ Epidemiol. 2000 Mar-Apr;10(2):126-35
references.pmid: 10791594
references.citation: J Agric Food Chem. 2008 Aug 13;56(15):5984-8
references.pmid: 18624430
references.citation: Nature. 2008 Apr 3;452(7187):638-642
references.pmid: 18385739
references.citation: Clin Cancer Res. 2005 Aug 15;11(16):6087-93
references.pmid: 16115954
references.citation: IARC Monogr Eval Carcinog Risks Hum. 1993;58:1-415
references.pmid: 8022054
references.citation: J Natl Cancer Inst. 1999 Jul 21;91(14):1194-210
references.pmid: 10413421
references.citation: Exp Toxicol Pathol. 2006 Nov;58(2-3):101-24
references.pmid: 16973339
references.citation: Cancer Res. 2009 Nov 1;69(21):8236-40
references.pmid: 19843845
references.citation: IARC Monogr Eval Carcinog Risks Hum. 2006;88:1-478
references.pmid: 17366697
references.citation: Clin Chem Lab Med. 2009;47(3):311-20
references.pmid: 19676143
references.citation: Am J Epidemiol. 2008 Apr 1;167(7):759-74
references.pmid: 18270371
references.citation: J Toxicol Environ Health A. 2007 Oct;70(20):1779-82
references.pmid: 17885936
references.citation: Chem Res Toxicol. 2007 Jan;20(1):108-13
references.pmid: 17226933
references.citation: Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15404-9
references.pmid: 17030796
references.citation: Pharmacol Rev. 2005 Mar;57(1):79-115
references.pmid: 15734728