title: Breast lesion sizing by B-mode imaging and sonoelastography in comparison to histopathological sizing--a prospective study.
abstract: OBJECTIVE
  This prospective study evaluates whether sonoelastography can improve B-mode ultrasonographic sizing of breast tumors. Precise measuring is important for effective therapy planning for breast cancer patients.
  
  
  METHODS
  The size of 100 surgically excised breast lesions (92 patients: 77 malignant, 23 benign) was compared to preoperative measurements. Lesions were imaged with both ultrasonographic techniques in identical planes. The largest sizes measured with each modality were compared to the largest histopathological measurements. The interobserver variability was also computed from measurements made by two examiners assessing identical planes.
  
  
  RESULTS
  Both ultrasonographic measuring techniques underestimate lesion size. The sonoelastography measurements were within ± 5 mm of the histological size in 70.1 % of malignant lesions, and the B-mode measurements in 57.1 % of cases. Sonoelastography leads to more accurate measurements of 13.0 % of cases (statistically not significant). A total of 22 lesions were also imaged by a second examiner. Sonoelastography had 27.3 % less interobserver variability (examiners agreed in 36.4 % of sonoelastography and in 9.1 % of B-mode results).
  
  
  CONCLUSIONS
  In this study there is no significant advantage of sonoelastography, although a tendency is apparent. The low interobserver variability also favors sonoelastography for preoperative diagnostics, since it may be less dependent on the observer than conventional B-mode imaging. The results of this prospective study require validation in a prospective multicenter study with larger case numbers.
authors.affiliation: Department of Gynecology & Obstetrics, E-M-A-University, Greifswald, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Isermann
authors.forename: S
authors.initials: S
authors.lastname: Grunwald
authors.forename: G
authors.initials: G
authors.lastname: Hatzung
authors.forename: D
authors.initials: D
authors.lastname: Könsgen-Mustea
authors.forename: P-O
authors.initials: PO
authors.lastname: Behrndt
authors.forename: A-A
authors.initials: AA
authors.lastname: Geaid
authors.forename: B
authors.initials: B
authors.lastname: Jäger
authors.forename: R
authors.initials: R
authors.lastname: Ohlinger
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001940:Breast / Q000473:pathology; D047688:Breast Cyst / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000601:surgery; D003937:Diagnosis, Differential; D054459:Elasticity Imaging Techniques; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008875:Middle Aged; D015588:Observer Variation; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D047368:Tumor Burden / Q000502:physiology*; D016217:Ultrasonography, Mammary; D055815:Young Adult