Clinical and biochemical parameters in relation to serum leptin levels in South Indian children and adolescents.
OBJECTIVE
To investigate the relationship between serum leptin and lipid profile in South Indian School children and adolescents, and to evaluate the role of serum leptin in obese, overweight and congenital heart diseased children and adolescents; in South Indian population and its correlation with anthropometric and biochemical parameters.


METHODS
The study included 185 school going children and adolescents. (52 obese, 49 overweight, 25 congenital heart disease children and adolescents, were compared with 59 normal controls, aged between 10-17 years). Anthropometric variables, lipid profile, fasting serum glucose were analyzed by autoanalyser and serum leptin by ELISA.


RESULTS
Serum leptin levels were significantly elevated in obese and overweight children than in control children (36.88+/-18.60ng/mL, 20.64+/-11.18ng/mL vs 7.97+/-2.79ng/mL; p value <0.001), and decreased in congenital heart diseased children than in control children (6.20+/-4.23 ng/mL vs 7.97+/-2.79ng/mL; p value <0.005).


CONCLUSIONS
This study provides a good relationship between serum leptin levels and anthropometric and biochemical parameters, such as total cholesterol, triglycerides and LDL-cholesterol. We observed negative correlation between serum leptin and fasting glucose levels and HDL-cholesterol levels were found to be non-significant among the groups. Further studies with large sample size are needed to ascertain the relationship between serum leptin and lipid profile in different groups of children and adolescents.
Rao
Srinivasa Nageswara
SN
Department of Biochemistry, International Centre for Cardio-Thoracic and Vascular Diseases, Chennai, India.
Gurumurthy
G Prema
GP
Gururajan
Priya
P
Arumugam
Sarasa Barathi
SB
Saibabu
Kirthivasan
V
V
Cherian
K M
KM
D000293:Adolescent; D000704:Analysis of Variance; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood*; D006801:Humans; D007194:India; D020738:Leptin / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood*; D050177:Overweight / Q000097:blood*
D015415:Biomarkers; D020738:Leptin; D008055:Lipids
Obes Res. 2005 Aug;13(8):1476-84
16129731
Pediatrics. 2005 Apr;115(4):e500-3
15741351
J Clin Invest. 1997 Aug 15;100(4):808-13
9259579
J Clin Endocrinol Metab. 1997 Jul;82(7):2148-52
9215286
Ann Intern Med. 1997 Jan 1;126(1):26-31
8992920
Eur J Clin Nutr. 2007 Jun;61(6):719-26
17164827
Obes Res. 2003 Apr;11(4):532-40
12690082
J Clin Invest. 2000 May;105(9):1243-52
10791999
Indian Pediatr. 2007 Apr;44(4):257-62
17468520
J Intern Med. 1999 Oct;246(4):409-18
10583712
J Clin Endocrinol Metab. 1996 Nov;81(11):3909-13
8923837
Eur J Epidemiol. 2001;17(10):911-6
12188009
Indian J Pediatr. 2006 Jul;73(7):593-6
16877853
Pediatrics. 1996 Aug;98(2 Pt 1):201-3
8692618
Int J Cardiol. 2003 Nov;92(1):93-7
14602223