title: Antimicrobial, antiviral and cytotoxic activity of extracts and constituents from Polygonum spectabile Mart.
abstract: Polygonum spectabile is used in Brazil for treatment of several infection diseases. Extracts and constituents isolated from this species were evaluated for cytotoxicity and effects on 15 bacterias and yeasts as well on 4 viruses strains (HHV-1, VACV-WR, EMCV, DEN-2). Less polar extracts were effective against Staphylococcus aureus, Bacillus subtillis, Micrococcus luteus, M. canis and Tricophyton mentagrophytes and T. rubrum. Two known chalcones and 3-O-β-D-glucosyl-β-sitosterol were isolated. The ethanol extract was the only one to show antiviral activity (CE50 < 30 μg/ml). One chalcone has inhibited the growth of several bacteria and was significantly active against dermathophytes. The 3 compounds isolated have shown moderate cytotoxicity against Vero and LLCMK(2) cells (CC(50) < 50 μg/ml). These results support the use of P. spectabile as antimicrobial agent.
authors.affiliation: Departamento de Produtos Farmacêuticos, Faculdade de Farmácia, UFMG, Av. Antônio Carlos 6627, 31270-901 Belo Horizonte, MG, Brazil.
authors.forename: Geraldo Célio
authors.initials: GC
authors.lastname: Brandão
authors.forename: Erna Gessien
authors.initials: EG
authors.lastname: Kroon
authors.forename: Maria Gorette R
authors.initials: MG
authors.lastname: Duarte
authors.forename: Fernão Castro
authors.initials: FC
authors.lastname: Braga
authors.forename: José Dias
authors.initials: JD
authors.lastname: de Souza Filho
authors.forename: Alaíde Braga
authors.initials: AB
authors.lastname: de Oliveira
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002460:Cell Line; D047188:Chalcones / Q000302:isolation & purification / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D003603:Cytotoxins / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D028502:Polygonum / Q000737:chemistry*; D012855:Sitosterols / Q000302:isolation & purification / Q000494:pharmacology*; D014709:Vero Cells; D014780:Viruses / Q000187:drug effects; D015003:Yeasts / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000998:Antiviral Agents; D047188:Chalcones; D003603:Cytotoxins; D010936:Plant Extracts; D012855:Sitosterols