Association of ADRB1 gene polymorphism with atrial fibrillation.
OBJECTIVE
The purpose of this study was to establish the probability and patterns of atrial fibrillation (AF) inheritance in families, and to find an association of primary and secondary AF with polymorphism Ser49Gly of the gene encoding beta1-adrenoreceptor (ADRB1).


METHODS
We examined 103 probands with AF and 301 relatives. Physical examination, electrocardiography (ECG), echocardiography, Holter's monitoring of ECG, and other methods of functional diagnostics have been performed for all patients and their relatives. Genetic study has been performed using DNA extracted from peripheral blood leukocytes.


RESULTS
Our results show that probands with primary AF and their relatives have a prevalence of the heterozygous genotype (Ser49Gly) of ADRB1 gene compared with the control group: 15 (50.0%) probands and 11 (44.0%) relatives, respectively, and 38 (19.2%) in the control group (p < 0.05). Significant prevalence of heterozygous genotype (Ser49Gly) of ADRB1 gene was observed in patients of the second subgroup with secondary AF: 14 (46.7%) persons in comparison with 38 (19.2%) persons of the control group (p < 0.05).


CONCLUSIONS
Heterozygous genotype (Ser49Gly) of ADRB1 gene can be considered as one of the genetic predictors for development of primary or secondary AF. Relatives of probands with primary AF and genotype Ser49Gly should be included in the risk group for developing AF.
Nicoulina
Svetlana
S
Krasnoyarsk State Medical University, Krasnoyarsk, Russia. nicoulina@mail.ru
Shulman
Vladimir
V
Shesternya
Pavel
P
Chernova
Anna
A
Salmina
Alla
A
Issachenko
Oksana
O
Maksimov
Vladimir
V
Voevoda
Mikhail
M
D000328:Adult; D019943:Amino Acid Substitution; D001281:Atrial Fibrillation / Q000209:etiology / Q000235:genetics*; D001483:Base Sequence; D016022:Case-Control Studies; D017931:DNA Primers / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018342:Receptors, Adrenergic, beta-1 / Q000235:genetics*
C547787:ADRB1 protein, human; D017931:DNA Primers; D005819:Genetic Markers; D018342:Receptors, Adrenergic, beta-1