Gel formulations for treatment of the ophthalmic complications in cystinosis.
Nephropathic cystinosis is a rare autosomal recessive disease characterised by raised lysosomal levels of cystine in the cells of all organs. It is treated by regular administration of the aminothiol, cysteamine. Corneal crystal deposition is one of the most troublesome complications affecting patients and requires the hourly administration of cysteamine eye drops. In an attempt to reduce this frequency and improve the treatment, the preparation and evaluation of cysteamine containing Carbomer gel is reported. The results demonstrated that a weak gel network was formed at low shear-stress, the bioadhesion of the gel was increased with inclusion of a cysteamine derivative (e.g. mean force of 0.067N compared to 0.107N with compound included) and first-order release from the gel was observed. In conclusion these results offer the possibility to formulate cysteamine in an ocular applicable gel formulation.
Buchan
Barbara
B
School of Pharmacy and Life Sciences, The Robert Gordon University, Schoolhill, Aberdeen, UK.
Kay
Graeme
G
Heneghan
Anne
A
Matthews
Kerr H
KH
Cairns
Donald
D
D000180:Acrylic Resins / Q000737:chemistry*; D000268:Adhesiveness; D000818:Animals; D002417:Cattle; D003315:Cornea / Q000187:drug effects*; D003316:Corneal Diseases / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D003543:Cysteamine / Q000008:administration & dosage* / Q000737:chemistry / Q000627:therapeutic use; D003554:Cystinosis / Q000150:complications* / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding; D005782:Gels; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D015394:Molecular Structure; D010649:Phenylalanine / Q000737:chemistry; D012212:Rheology; D012995:Solubility
D000180:Acrylic Resins; D004337:Drug Carriers; D005782:Gels; D010649:Phenylalanine; C006903:carbopol 940; D003543:Cysteamine