Primary hepatic burkitt lymphoma presenting with acute liver failure.
BACKGROUND
We report the first case of immunophenotypically confirmed primary hepatic Burkitt lymphoma presenting with acute liver failure. The patient survived following an aggressive diagnostic approach followed by emergent chemotherapy.


CONCLUSIONS
Data from the primary hepatic non-Hodgkin lymphoma literature show a survival rate of 87% at 5 years with combination regimens of chemotherapy. However, mortality rate in this population is 85% in patients with acute liver failure.


CONCLUSIONS
Primary hepatic Burkitt lymphoma may respond well to emergent chemotherapy even in the setting of acute liver failure.
Mattar
Wissam E
WE
Division of Gastroenterology and Hepatology, Washington Hospital Center, 110 Irving St NW, Rm no 3A-3, Washington, DC 20010, USA. wissam.e.mattar@medstar.net
Alex
Biju K
BK
Sherker
Averell H
AH
D058846:Antibodies, Monoclonal, Murine-Derived / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D002051:Burkitt Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D003561:Cytarabine / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy; D006801:Humans; D017114:Liver Failure, Acute / Q000209:etiology* / Q000503:physiopathology; D008113:Liver Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D000069283:Rituximab
D058846:Antibodies, Monoclonal, Murine-Derived; D003561:Cytarabine; D000069283:Rituximab; D003907:Dexamethasone
Eur J Gastroenterol Hepatol. 1997 Nov;9(11):1113-5
9431904
Int J Infect Dis. 2000;4(1):57-8
10689218
Int J Cancer. 2009 Apr 15;124(8):1745-55
19165855
Cancer. 2001 Oct 15;92(8):2023-9
11596015
Korean J Gastroenterol. 2008 Apr;51(4):259-64
18516006
Lancet Oncol. 2003 Jan;4(1):22-9
12517536
Hepatology. 1991 May;13(5):870-5
2029991
Acta Haematol. 2001;105(4):237-40
11528098
Blood. 2004 Nov 15;104(10):3009-20
15265787
Am J Gastroenterol. 2003 Jul;98(7):1641-6
12873593
Gut. 1998 Apr;42(4):576-80
9616324
Leuk Lymphoma. 2001 Feb;40(5-6):667-70
11426539
Clin Radiol. 2006 May;61(5):453-5
16679121