title: A link between stent radial forces and vascular wall remodeling: the discovery of an optimal stent radial force for minimal vessel restenosis.
abstract: Coronary and peripheral artery disease (PAD) continue to be primary causes of morbidity and mortality in western nations; percutaneous transluminal angioplasty (PTA) with stenting has become a popular treatment. Unfortunately, restenosis is a significant problem following intravascular stent placement. This study considers the contribution of stent forces in vascular stenosis and remodeling to develop an equation for identifying the optimal stent force. z-Type stents of three radial forces [low (3.4 N), high (16.4 N), and ultrahigh (19.4 N)] were deployed into the iliac arteries of a juvenile porcine model. Vessel diameters were measured before, after deployment, and again at 30 days. At 30 days animals were killed and the vessels fixed in situ. After implantation, there was a significant increase in total thickness and neointimal hyperplasia with increasing stent force. The model for vessel radius and experimental data was in agreement. The model shows that maximum late-term radius is achieved with a stent deployment stress of 480 kPa, which occurs at the end of the stress-strain curve nonlinear domain and beginning of the high-strain collagen domain. The results and calculations suggest that an optimal stent force exists that is subject to the geometry, structure, and mechanics of the target vessel. To achieve maximum late-term dilatation, stents should not produce stress in the vessel wall greater than the end of the transitional domain of the vessel's stress-strain curve. This finding is extremely important for vascular stent development and will be expanded to preliminary vessel wall injury and atherosclerotic models.
authors.affiliation: Virginia Tech-Wake Forest School of Biomedical Engineering and Sciences, Blacksburg, Virginia, USA. jwfreeman@vt.edu
authors.forename: Joseph W
authors.initials: JW
authors.lastname: Freeman
authors.forename: Patrick B
authors.initials: PB
authors.lastname: Snowhill
authors.forename: John L
authors.initials: JL
authors.lastname: Nosher
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001808:Blood Vessels / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D001835:Body Weight; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007083:Iliac Artery / Q000000981:diagnostic imaging / Q000473:pathology; D015607:Stents; D013314:Stress, Mechanical; D034421:Sus scrofa; D017539:Tunica Intima / Q000473:pathology / Q000503:physiopathology; D018084:Ultrasonography, Interventional