title: Identification of tri- and tetracyclic pyrimidinediones as sirtuin inhibitors.
authors.affiliation: Istituto Pasteur - Fondazione Cenci Bolognetti, Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza Università di Roma, Italy.
authors.forename: Dante
authors.initials: D
authors.lastname: Rotili
authors.forename: Domenico
authors.initials: D
authors.lastname: Tarantino
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Carafa
authors.forename: Ester
authors.initials: E
authors.lastname: Lara
authors.forename: Sarah
authors.initials: S
authors.lastname: Meade
authors.forename: Giorgia
authors.initials: G
authors.lastname: Botta
authors.forename: Angela
authors.initials: A
authors.lastname: Nebbioso
authors.forename: Jörg
authors.initials: J
authors.lastname: Schemies
authors.forename: Manfred
authors.initials: M
authors.lastname: Jung
authors.forename: Aleksey G
authors.initials: AG
authors.lastname: Kazantsev
authors.forename: Manel
authors.initials: M
authors.lastname: Esteller
authors.forename: Mario F
authors.initials: MF
authors.lastname: Fraga
authors.forename: Lucia
authors.initials: L
authors.lastname: Altucci
authors.forename: Antonello
authors.initials: A
authors.lastname: Mai
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D056572:Histone Deacetylase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D006801:Humans; D011744:Pyrimidinones / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D037761:Sirtuins / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D056572:Histone Deacetylase Inhibitors; D011744:Pyrimidinones; D037761:Sirtuins