Bacterial proteases from the intracellular vacuole niche; protease conservation and adaptation for pathogenic advantage.
Proteases with important roles for bacterial pathogens that specifically reside within intracellular vacuoles are frequently homologous to those that have important virulence functions for other bacteria. Research has identified that some of these conserved proteases have evolved specialized functions for intracellular vacuole-residing bacteria. Unique proteases with pathogenic functions have also been described from Chlamydia, Mycobacteria, and Legionella. These findings suggest that there are further novel functions for proteases from these bacteria that remain to be described. This review summarizes the recent findings of novel protease functions from the intracellular human pathogenic bacteria that reside exclusively in vacuoles.
Huston
Wilhelmina M
WM
Institute of Health and Biomedical Innovation and School of Life Sciences, Queensland University of Technology, Brisbane, QLD, Australia. w.huston@qut.edu.au
D001419:Bacteria / Q000201:enzymology* / Q000472:pathogenicity*; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D017124:Conserved Sequence; D006801:Humans; D010447:Peptide Hydrolases / Q000235:genetics / Q000502:physiology*; D014617:Vacuoles / Q000201:enzymology*; D037521:Virulence Factors / Q000235:genetics / Q000502:physiology*
D001426:Bacterial Proteins; D037521:Virulence Factors; D010447:Peptide Hydrolases