title: Inflammatory response in Parkinsonism.
abstract: Inflammatory responses have been proposed as important factors in dopaminergic neuro-degeneration in Parkinsonism. Increasing evidence suggests that the alteration of the glial microenvironment induced by neuronal degeneration could be deleterious to the remaining neurons. The activation of microglia/macrophages and reactive astrocytes may have a negative effect on the surrounding parenchyma, perpetuating the neurodegenerative process. However, this alteration may also go beyond the brain parenchyma and stimulate other inflammatory changes in other systems, inducing the release of proinflammatory cytokines and probably Acute Phase Proteins (APP) and Glucocorticoids (GC). In this work we review the latest advances in the field to provide a picture of the state of the art of studies of inflammatory responses and Parkinsonism, hopefully opening up new therapeutic perspectives for patients with Parkinson's disease.
authors.affiliation: Clinical and Experimental Neuroscience, Department of Human Anatomy, Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas, School of Medicine, University of Murcia, Campus de Espinardo, Murcia 30100, Spain. barcia@um.es
authors.forename: Carlos
authors.initials: C
authors.lastname: Barcia
authors.forename: Francisco
authors.initials: F
authors.lastname: Ros
authors.forename: María Angeles
authors.initials: MA
authors.lastname: Carrillo
authors.forename: David
authors.initials: D
authors.lastname: Aguado-Llera
authors.forename: Carmen María
authors.initials: CM
authors.lastname: Ros
authors.forename: Aurora
authors.initials: A
authors.lastname: Gómez
authors.forename: Cristina
authors.initials: C
authors.lastname: Nombela
authors.forename: Vicente
authors.initials: V
authors.lastname: de Pablos
authors.forename: Emiliano
authors.initials: E
authors.lastname: Fernández-Villalba
authors.forename: Maria-Trinidad
authors.initials: MT
authors.lastname: Herrero
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D005938:Glucocorticoids / Q000378:metabolism; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000473:pathology; D009457:Neuroglia / Q000378:metabolism; D020734:Parkinsonian Disorders / Q000150:complications* / Q000188:drug therapy / Q000266:history / Q000276:immunology* / Q000473:pathology
chemical_list: D016207:Cytokines; D005938:Glucocorticoids