title: PLCgamma2: where bone and immune cells find their common ground.
abstract: Identifying common signaling pathways to bone and immune system may lead to better therapeutic approaches in diseases such as inflammatory arthritis. In this context, PLCgamma2 seems to be a promising target. PLCgamma2 modulates bone homeostasis by affecting osteoclast recruitment and function. Via its catalytic activity and the adapter domains, PLCgamma2 controls RANKL and alphavbeta3 integrin-dependent signaling pathways in the resorbing cell. Thus, mice lacking PLCgamma2 are osteopetrotic. PLCgamma2 also regulates neutrophil degranulation after beta2 integrin-dependent attachment. Indeed PLCgamma2(-/-) mice are protected from K/BxN serum transfer arthritis, which is known to require neutrophil activation. These studies position PLCgamma2 as a critical regulator of the cellular and molecular mechanisms occurring in bone and immune cells during autoimmune inflammation.
authors.affiliation: Department of Orthopedics, Washington University School of Medicine, St. Louis, Missouri, USA. faccior@ wustl.edu
authors.forename: Roberta
authors.initials: R
authors.lastname: Faccio
authors.forename: Viviana
authors.initials: V
authors.lastname: Cremasco
mesh_terms: D000818:Animals; D001168:Arthritis / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D001327:Autoimmune Diseases / Q000235:genetics / Q000378:metabolism; D001842:Bone and Bones / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D006706:Homeostasis / Q000276:immunology / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D051966:Phospholipase C gamma / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D051966:Phospholipase C gamma