Physicochemical and pharmacokinetic parameters in drug selection and loading for transdermal drug delivery.
Skin of an average adult body covers a surface of approximately 2 m2 and receives about one-third of the blood circulating through the body. The transdermal route of administration cannot be employed for a large number of drugs. The rationality of drug selection based on pharmacokinetic parameters and physicochemical properties of the drug are the important factors to be considered for deciding its suitability of drug for delivery by transdermal route.
Chandrashekar
N S
NS
Department of Pharmaceutics, Al-Ameen College of Pharmacy, Hosur Road, Bangalore - 560 027, India.
Shobha Rani
R H
RH
Pharm Sci Technol Today. 2000 Sep 1;3(9):318-326
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