title: Episodic, transient systemic acidosis delays evolution of the malignant phenotype: Possible mechanism for cancer prevention by increased physical activity.
abstract: BACKGROUND
  The transition from premalignant to invasive tumour growth is a prolonged multistep process governed by phenotypic adaptation to changing microenvironmental selection pressures. Cancer prevention strategies are required to interrupt or delay somatic evolution of the malignant invasive phenotype. Empirical studies have consistently demonstrated that increased physical activity is highly effective in reducing the risk of breast cancer but the mechanism is unknown.
  
  
  RESULTS
  Here we propose the hypothesis that exercise-induced transient systemic acidosis will alter the in situ tumour microenvironment and delay tumour adaptation to regional hypoxia and acidosis in the later stages of carcinogenesis. We test this hypothesis using a hybrid cellular automaton approach. This model has been previously applied to somatic evolution on epithelial surfaces and demonstrated three phases of somatic evolution, with cancer cells escaping in turn from the constraints of limited space, nutrient supply and waste removal. In this paper we extend the model to test our hypothesis that transient systemic acidosis is sufficient to arrest, or at least delay, transition from in situ to invasive cancer.
  
  
  CONCLUSIONS
  Model simulations demonstrate that repeated episodes of transient systemic acidosis will interrupt critical evolutionary steps in the later stages of carcinogenesis resulting in substantial delay in the evolution to the invasive phenotype. Our results suggest transient systemic acidosis may mediate the observed reduction in cancer risk associated with increased physical activity.
authors.affiliation: Manchester Centre for Integrative Systems Biology, Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester, M1 7DN, UK. kieran.smallbone@manchester.ac.uk
authors.forename: Kieran
authors.initials: K
authors.lastname: Smallbone
authors.forename: Philip K
authors.initials: PK
authors.lastname: Maini
authors.forename: Robert A
authors.initials: RA
authors.lastname: Gatenby
mesh_terms: D000138:Acidosis / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D006801:Humans; D009043:Motor Activity / Q000502:physiology*; D009369:Neoplasms / Q000378:metabolism* / Q000517:prevention & control*
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