title: Formation of spray-dried powder of S-adenosyl-L-methionine.
abstract: S-Adenosyl-L-methionine (SAM) is an essential metabolite in all living organisms. In clinical research, SAM has also been suggested as a chemotherapeutic agent in various diseases. The main problem of SAM is its instability at high temperatures, at neutral and alkaline pH, and in the presence of humidity. SAM retention in spray-dried powder was determined under various conditions of spray-drying. The highest SAM retention was obtained when maltodextrin (dextrose equivalent, DE, of 25) was used as the carrier solid with the SAM feed liquid at pH 4.0. The water content in the powder had a significant effect on the stability of SAM. SAM powder with lower water content exhibited higher stability.
authors.affiliation: Department of Biotechnology, Graduate school of Engineering, Tottori University, Tottori, Japan.
authors.forename: Vichuta
authors.initials: V
authors.lastname: Lauruengtana
authors.forename: Arisa
authors.initials: A
authors.lastname: Yanagita
authors.forename: Tze Loon
authors.initials: TL
authors.lastname: Neoh
authors.forename: Takeshi
authors.initials: T
authors.lastname: Furuta
authors.forename: Muneyoshi
authors.initials: M
authors.lastname: Kanai
authors.forename: Haruyuki
authors.initials: H
authors.lastname: Iefuji
authors.forename: Hidefumi
authors.initials: H
authors.lastname: Yoshii
mesh_terms: D003890:Desiccation; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D011134:Polysaccharides / Q000737:chemistry; D011208:Powders / Q000737:chemistry*; D012436:S-Adenosylmethionine / Q000737:chemistry*; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D011134:Polysaccharides; D011208:Powders; D014867:Water; C008315:maltodextrin; D012436:S-Adenosylmethionine