title: Clinical and virological features of Dengue in Vietnamese infants.
abstract: BACKGROUND
  Infants account for a small proportion of the overall dengue case burden in endemic countries but can be clinically more difficult to manage. The clinical and laboratory features in infants with dengue have not been extensively characterised.
  
  
  RESULTS
  This prospective, cross-sectional descriptive study of infants hospitalized with dengue was conducted in Vietnam from November 2004 to December 2007. More than two-thirds of 303 infants enrolled on clinical suspicion of dengue had a serologically confirmed dengue virus (DENV) infection. Almost all were primary dengue infections and 80% of the infants developed DHF/DSS. At the time of presentation and during hospitalization, the clinical signs and symptoms in infants with dengue were difficult to distinguish from those with other febrile illnesses, suggesting that in infants early laboratory confirmation could assist appropriate management. Detection of plasma NS1 antigen was found to be a sensitive marker of acute dengue in infants with primary infection, especially in the first few days of illness.
  
  
  CONCLUSIONS
  Collectively, these results provide a systematic description of the clinical features of dengue in infants and highlight the value of NS1 detection for diagnosis.
authors.affiliation: Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
authors.forename: Tran Nguyen Bich
authors.initials: TN
authors.lastname: Chau
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Anders
authors.forename: Le Bich
authors.initials: le B
authors.lastname: Lien
authors.forename: Nguyen Thanh
authors.initials: NT
authors.lastname: Hung
authors.forename: Lu Thi Minh
authors.initials: LT
authors.lastname: Hieu
authors.forename: Nguyen Minh
authors.initials: NM
authors.lastname: Tuan
authors.forename: Tran Thi
authors.initials: TT
authors.lastname: Thuy
authors.forename: Le Thi
authors.initials: le T
authors.lastname: Phuong
authors.forename: Nguyen Thi Hong
authors.initials: NT
authors.lastname: Tham
authors.forename: Mai Ngoc
authors.initials: MN
authors.lastname: Lanh
authors.forename: Jeremy J
authors.initials: JJ
authors.lastname: Farrar
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Whitehead
authors.forename: Cameron P
authors.initials: CP
authors.lastname: Simmons
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D003715:Dengue / Q000175:diagnosis / Q000473:pathology* / Q000821:virology; D003716:Dengue Virus / Q000302:isolation & purification*; D005260:Female; D006760:Hospitalization; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014744:Vietnam; D017361:Viral Nonstructural Proteins / Q000097:blood; D055815:Young Adult
chemical_list: D017361:Viral Nonstructural Proteins
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