AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4.
A Chinese rhesus macaque infected with the pathogenic CCR5-tropic clade C simian-human immunodeficiency virus, SHIV-1157ipd3N4, had persistent viremia, depletion of CD4(+) T cells to <200 cells/μl, opportunistic infections, coagulopathy, and gradual development of bilateral blindness. MRI revealed marked thickening of both optic nerves. Histopathological evaluation showed diffuse cellular infiltration at necropsy and a focus of SHIV-infected cells. This is the first report of CNS pathology following chronic infection with an obligate R5 SHIV.
García
Anapatricia
A
Yerkes National Primate Research Center, Emory University, Atlanta, GA, USA. agarci5@emory.edu
Siddappa
Nagadenahalli B
NB
Li
Qingsheng
Q
Haase
Ashley T
AT
Paul
Katherine
K
Stroud
Fawn
F
Zhang
Xiaodong
X
Fountain
Jack A
JA
Villinger
François
F
Novembre
Francis J
FJ
Else
James G
JG
Evan Secor
W
W
Ruprecht
Ruth M
RM
D017088:AIDS-Related Opportunistic Infections / Q000662:veterinary / Q000821:virology; D000818:Animals; D005260:Female; D015497:HIV-1 / Q000235:genetics*; D008253:Macaca mulatta; D008992:Monkey Diseases / Q000821:virology*; D009902:Optic Neuritis / Q000662:veterinary* / Q000821:virology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000235:genetics*; D014766:Viremia
J Leukoc Biol. 2006 Nov;80(5):965-72
16923919
J Clin Virol. 2008 Mar;41(3):180-5
18164651
Br J Ophthalmol. 2000 May;84(5):551-3
10847713
PLoS Negl Trop Dis. 2008 Jul 23;2(7):e265
18648516
Science. 1999 Nov 12;286(5443):1353-7
10558989
J Virol. 2009 Feb;83(3):1422-32
19019970
Retrovirology. 2008 Oct 17;5:94
18928523
J Neurovirol. 2008 Aug;14(4):309-17
18780232
J Neurovirol. 2008 Aug;14(4):292-300
18780230
J Neurovirol. 2008 Aug;14(4):318-26
18780233
AIDS. 2006 Nov 14;20(17):2135-40
17086052
J Virol. 2006 Sep;80(17):8729-38
16912320