title: Identification of natural product fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening.
abstract: Fonsecin B has been identified as stabilizing ligand of c-myc G-quadruplex DNA using high-throughput virtual screening of a natural product database, and inhibited Taq polymerase-mediated DNA extension in vitro through stabilization of the G-quadruplex secondary structure.
authors.affiliation: Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong.
authors.forename: Ho-Man
authors.initials: HM
authors.lastname: Lee
authors.forename: Daniel Shiu-Hin
authors.initials: DS
authors.lastname: Chan
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.forename: Ho-Yu
authors.initials: HY
authors.lastname: Lam
authors.forename: Siu-Cheong
authors.initials: SC
authors.lastname: Yan
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
authors.forename: Dik-Lung
authors.initials: DL
authors.lastname: Ma
authors.forename: Chung-Hang
authors.initials: CH
authors.lastname: Leung
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000737:chemistry; D054856:G-Quadruplexes; D006575:Heterocyclic Compounds, 3-Ring / Q000737:chemistry* / Q000494:pharmacology; D057166:High-Throughput Screening Assays; D008024:Ligands; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*
chemical_list: D001688:Biological Products; D006575:Heterocyclic Compounds, 3-Ring; D008024:Ligands; D016271:Proto-Oncogene Proteins c-myc; C552278:fonsecin B; D004247:DNA