Pathophysiology of degenerative disc disease.
The intervertebral disc is characterized by a tension-resisting annulus fibrosus and a compression-resisting nucleus pulposus composed largely of proteoglycan. The most important function of the annulus and nucleus is to provide mechanical stability to the disc. Degenerative disc disease in the lumbar spine is a serious health problem. Although the three joint complex model of the degenerative process is widely accepted, the etiological basis of this degeneration is poorly understood. With the recent progress in molecular biology and modern biological techniques, there has been dramatic improvement in the understanding of aging and degenerative changes of the disc. Knowledge of the pathophysiology of the disc degeneration can help in the appropriate choice of treatment and to develop tissue engineering for biological restoration of degenerated discs.
Choi
Yong-Soo
YS
Department of Orthopedic Surgery, Kwangju Christian Hospital, Gwangju, Korea.
Tissue Cell. 1982;14(2):359-69
7202266
J Bone Joint Surg Br. 2001 May;83(4):491-5
11380116
Eur Spine J. 1996;5(4):220-4
8886732
Spine (Phila Pa 1976). 1997 Sep 1;22(17):2044-9
9306537
Acta Orthop Scand. 1974;45(4):540-9
4281255
J Neurosurg. 1964 Dec;21:1070-5
14279827
Anat Rec. 1982 Dec;204(4):307-14
7181135
J Bone Joint Surg Am. 1990 Mar;72(3):403-8
2312537
Spine (Phila Pa 1976). 2006 Mar 1;31(5):560-6
16508552
Eur Spine J. 2006 Aug;15 Suppl 3:S312-6
16773379
Spine (Phila Pa 1976). 1996 Jan 15;21(2):235-41
8720410
Spine (Phila Pa 1976). 1996 Feb 15;21(4):415-20
8658243
Nat Genet. 2005 Jun;37(6):607-12
15864306
Spine (Phila Pa 1976). 2006 Jul 15;31(16):1810-4
16845356
Acta Orthop Scand. 1945;16(1):40-2
21018457
Surg Neurol. 1996 Jul;46(1):14-8
8677479
J Bone Joint Surg Am. 1991 Jan;73(1):124-8
1824705
Spine (Phila Pa 1976). 2001 Dec 1;26(23):2543-9
11725234
J Pediatr Orthop. 1982;2(5):528-33
6219127
Spine (Phila Pa 1976). 2001 Mar 1;26(5):461-2
11242371
Orthop Clin North Am. 1983 Jul;14(3):491-504
6346204
Clin Orthop Relat Res. 1974 Mar-Apr;(99):30-50
4274946
J Bone Joint Surg Am. 2006 Apr;88 Suppl 2:68-71
16595447
Spine (Phila Pa 1976). 1979 May-Jun;4(3):267-78
157533
J Bone Joint Surg Br. 1996 Nov;78(6):965-72
8951017
J Pediatr Orthop. 1985 Sep-Oct;5(5):550-2
2931450
Spine (Phila Pa 1976). 2001 Sep 15;26(18):1997-2000
11547199
Spine J. 2006 Jul-Aug;6(4):380-4
16825042
Spine (Phila Pa 1976). 1992 Jun;17(6 Suppl):S129-32
1631712
J Dairy Sci. 1991 Aug;74(8):2778-87
1918549
Spine (Phila Pa 1976). 1990 May;15(5):383-6
1694599
Br Heart J. 1995 Mar;73(3):209-15
7727178
J Bone Joint Surg Am. 1950 Jan;32A(1):97-102
15401725
Spine (Phila Pa 1976). 2002 Dec 1;27(23):2691-6
12461395
Clin Orthop Relat Res. 1986 Sep;(210):243-5
3757370
Spine (Phila Pa 1976). 1995 Apr 15;20(8):928-35
7644958
Spine (Phila Pa 1976). 2007 Feb 1;32(3):321-7
17268263
J Bone Joint Surg Am. 1982 Sep;64(7):991-6
6214560
Spine (Phila Pa 1976). 2002 Dec 1;27(23):2631-44
12461389
Spine (Phila Pa 1976). 1988 Feb;13(2):173-8
3406837
Acta Orthop Scand. 1970;41(6):589-607
5516549
Spine (Phila Pa 1976). 1995 Jun 1;20(11):1307-14
7660243
J Neurosurg. 1973 Feb;38(2):232-4
4694222
Exp Cell Res. 1989 Sep;184(1):138-47
2551704