CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.
Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632).
Panayotopoulou
Effrosini G
EG
Laboratory of Medical Microbiology, Hellenic Pasteur Institute, Athens, Greece.
Sgouras
Dionyssios N
DN
Papadakos
Konstantinos S
KS
Petraki
Kalliopi
K
Breurec
Sébastien
S
Michopoulos
Spyros
S
Mantzaris
Gerassimos
G
Papatheodoridis
George
G
Mentis
Andreas
A
Archimandritis
Athanasios
A
D000328:Adult; D000368:Aged; D000942:Antigens, Bacterial / Q000235:genetics*; D001426:Bacterial Proteins / Q000235:genetics*; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D005260:Female; D016481:Helicobacter Infections / Q000382:microbiology / Q000473:pathology*; D016480:Helicobacter pylori / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010437:Peptic Ulcer / Q000382:microbiology; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D012720:Severity of Illness Index; D037521:Virulence Factors / Q000235:genetics*
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D004269:DNA, Bacterial; C074689:VacA protein, Helicobacter pylori; D037521:Virulence Factors; C080866:cagA protein, Helicobacter pylori
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