title: The effect of ultrasound on lipase-catalyzed regioselective acylation of mangiferin in non-aqueous solvents.
abstract: A simple and efficient method for regioselective acylation of mangiferin catalyzed by lipase under ultrasound irradiation is reported. Compared with the conventional methods, its main advantages are shorter reaction time and higher yields. The optimum conditions were screened out. Under the optimal conditions (lipase: PCL, acyl donor: vinyl acetate; reaction solvent: DMSO, reaction temperature: 45 degrees C, ultrasonic power: 200 W; substrate ratio: acyl donor/mangiferin 6/1, enzyme loading: 6 mg/ml), the regioselective acylation yield was up to 84%.
authors.affiliation: Key Laboratory for Molecular Enzymology and Engineering, Ministry of Education, Jilin University, Changchun, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Wang
authors.forename: Ren
authors.initials: R
authors.lastname: Wang
authors.forename: Jin
authors.initials: J
authors.lastname: Tian
authors.forename: Bo
authors.initials: B
authors.lastname: Zhao
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Wei
authors.forename: Ya-Lun
authors.initials: YL
authors.lastname: Su
authors.forename: Chun-Yuan
authors.initials: CY
authors.lastname: Li
authors.forename: Shu-Gui
authors.initials: SG
authors.lastname: Cao
authors.forename: Teng-Fei
authors.initials: TF
authors.lastname: Ji
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
mesh_terms: D000215:Acylation; D002384:Catalysis; D008049:Lipase / Q000378:metabolism* / Q000528:radiation effects*; D012997:Solvents; D013237:Stereoisomerism; D014753:Vinyl Compounds / Q000737:chemistry; D014867:Water; D044004:Xanthones / Q000737:chemistry*
chemical_list: D012997:Solvents; D014753:Vinyl Compounds; D044004:Xanthones; D014867:Water; C013592:mangiferin; D008049:Lipase