Triethanolamine-mediated palladium-catalyzed regioselective C-2 direct arylation of free NH-pyrroles.
An atom-economical phosphane-free palladium-catalyzed direct C-2 arylation of unactivated free NH-pyrroles is devised. This method provides a straightforward route to a wide variety of substituted 2-aryl-1H-pyrroles from readily accessible starting materials. Iodoarenes bearing electron-withdrawing and electron-donating substituents are tolerated under the presented reaction conditions. The scope of the reaction is also expanded to N-aryl and -alkylpyrroles albeit in lower yields.
Jafarpour
Farnaz
F
School of Chemistry, University College of Science, University of Tehran, P.O. Box 14155-6455, Tehran, Iran. jafarpur@khayam.ut.ac.ir
Rahiminejadan
Soraya
S
Hazrati
Hamideh
H
D002384:Catalysis; D004983:Ethanolamines / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000737:chemistry; D008956:Models, Chemical; D010165:Palladium / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
D004983:Ethanolamines; D006847:Hydrocarbons, Iodinated; D011758:Pyrroles; D010165:Palladium; C009546:triethanolamine