title: The efficacy of a modified chronomodulated infusion of oxaliplatin, 5-fluorouracil and leucovorin in advanced colorectal cancer (preliminary data).
abstract: OBJECTIVE
  To determine the efficacy and tolerability of a modified chronomodulated infusion of oxaliplatin, 5-fluorouracil (5-FU) and leucovorin in the treatment of advanced colorectal cancer.
  
  
  METHODS
  Sixteen patients with relapsed or metastatic colorectal cancer were treated with an intravenous infusion of oxaliplatin 25 mg/m(2), 5-FU 700 mg/m(2) and leucovorin 20 mg/m(2) on days 1 to 5. The infusion of oxaliplatin was chronomodulated with a peak delivery rate at 16:00 p.m., with 5-FU infused constantly overnight. Each course was repeated every 21 days.
  
  
  RESULTS
  The response rate was 38.5% (95% confidence interval [CI], 13.9% to 68.4%) in the 13 measurable patients, including 1 complete response (7.7%) and 4 partial responses (30.8%). Five patients (38.5%) had a stable disease and 3 (23.0%) a progressive disease. Three patients without a measurable lesion had improved status. The median time to progression and overall survival were 29 weeks and 85 weeks, respectively. Grade 3 thrombocytopenia occurred in 2.5% (2 cycles) and grade 3 vomiting in 12.5% (2 patients). Anorexia, stomatitis, diarrhea, pruritus, alopecia and peripheral neuropathy were mild and tolerable.
  
  
  CONCLUSIONS
  The modified chronomodulated infusion of oxaliplatin, 5-FU and leucovorin is effective and tolerable, but the number of patients was too small. Further study will be needed to confirm the efficacy of this regimen with a larger population of patients.
authors.affiliation: Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Korea.
authors.forename: Ji Young
authors.initials: JY
authors.lastname: Park
authors.forename: Si-Young
authors.initials: SY
authors.lastname: Kim
authors.forename: Jae Jin
authors.initials: JJ
authors.lastname: Lee
authors.forename: Hwi Joong
authors.initials: HJ
authors.lastname: Yoon
authors.forename: Kyung Sam
authors.initials: KS
authors.lastname: Cho
references.citation: Cancer Res Treat. 2002 Jun;34(3):218-22
references.pmid: 26680866
references.citation: Lancet. 1998 Oct 31;352(9138):1407-12
references.pmid: 9807986
references.citation: Cancer Res. 1993 Dec 15;53(24):5970-6
references.pmid: 8261411
references.citation: Ann Oncol. 1996 Jan;7(1):95-8
references.pmid: 9081400
references.citation: Ann Oncol. 1998 Jan;9(1):105-8
references.pmid: 9541691
references.citation: Cancer. 1999 Jun 15;85(12):2532-40
references.pmid: 10375099
references.citation: Cancer Res. 1993 Jun 15;53(12):2816-22
references.pmid: 8504424
references.citation: Cell. 1997 May 16;89(4):655-67
references.pmid: 9160756
references.citation: J Clin Oncol. 1998 Aug;16(8):2739-44
references.pmid: 9704726
references.citation: Biomed Pharmacother. 1989;43(4):251-60
references.pmid: 2790145
references.citation: Eur J Cancer. 1999 Sep;35(9):1338-42
references.pmid: 10658524
references.citation: Biomed Pharmacother. 1989;43(4):237-50
references.pmid: 2675999
references.citation: Cancer. 1992 Feb 15;69(4):893-900
references.pmid: 1735081
references.citation: Hepatogastroenterology. 2002 Mar-Apr;49(44):388-92
references.pmid: 11995458
references.citation: Ann Oncol. 1998 Nov;9(11):1251-3
references.pmid: 9862058
references.citation: Lancet. 1997 Sep 6;350(9079):681-6
references.pmid: 9291901
references.citation: J Clin Oncol. 1998 Jan;16(1):301-8
references.pmid: 9440757
references.citation: J Clin Oncol. 1989 Apr;7(4):425-32
references.pmid: 2926468
references.citation: J Natl Cancer Inst. 1994 Nov 2;86(21):1608-17
references.pmid: 7932825
references.citation: Cancer Res. 1990 Jan 1;50(1):197-201
references.pmid: 2293556
references.citation: J Clin Oncol. 1999 Nov;17(11):3560-8
references.pmid: 10550155
references.citation: Cancer Res. 1989 Jun 15;49(12):3362-8
references.pmid: 2720689
references.citation: J Clin Oncol. 1992 Jun;10(6):896-903
references.pmid: 1534121
references.citation: Eur J Cancer. 1993;29A(9):1280-4
references.pmid: 8343268
references.citation: J Clin Oncol. 2000 Jan;18(1):136-47
references.pmid: 10623704