[Synthetic peptide immunorphin as an instrument for studying nonopioid beta-endorphin receptor].
Research results of the synthetic decapeptide SLTCLVKGFY (the author's term is immunorphin) corresponding to the 364-373 sequence of G heavy-chain human immunoglobulin are summarized. Special attention is paid to the interaction between immunorphin and a nonopioid (insensitive to the opioid antagonist naloxone) beta-endorphin receptor. Using radioligand analysis, data were found regarding the distribution and functions of a nonopioid beta-endorphin receptor in human and animal bodies and the binding characteristics of immunorphin with a nonopioid receptor.
Kovalitskaia
Iu A
IuA
Navolotskaia
E V
EV
D000595:Amino Acid Sequence; D000818:Animals; D047108:Embryonic Development / Q000187:drug effects; D006801:Humans; D007127:Immunoglobulin Constant Regions / Q000494:pharmacology*; D007142:Immunoglobulin gamma-Chains / Q000494:pharmacology*; D008969:Molecular Sequence Data; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology*; D009928:Organ Specificity; D010446:Peptide Fragments / Q000494:pharmacology*; D018000:Receptors, Peptide / Q000378:metabolism*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D001615:beta-Endorphin / Q000378:metabolism* / Q000494:pharmacology
D007127:Immunoglobulin Constant Regions; D007142:Immunoglobulin gamma-Chains; D009292:Narcotic Antagonists; D009842:Oligopeptides; D010446:Peptide Fragments; D018000:Receptors, Peptide; C445661:immunorphin; D009270:Naloxone; D001615:beta-Endorphin