Multiphoton in vivo imaging of amyloid in animal models of Alzheimer's disease.
Amyloid-beta (Abeta) deposition is a defining feature of Alzheimer's disease (AD). The toxicity of Abeta aggregation is thought to contribute to clinical deficits including progressive memory loss and cognitive dysfunction. Therefore, Abeta peptide has become the focus of many therapeutic approaches for the treatment of AD due to its central role in the development of neuropathology of AD. In the past decade, taking the advantage of multiphoton microscopy and molecular probes for amyloid peptide labeling, the dynamic progression of Abeta aggregation in amyloid plaques and cerebral amyloid angiopathy has been monitored in real time in transgenic mouse models of AD. Moreover, amyloid plaque-associated alterations in the brain including dendritic and synaptic abnormalities, changes of neuronal and astrocytic calcium homeostasis, microglial activation and recruitment in the plaque location have been extensively studied. These studies provide remarkable insight to understand the pathogenesis and pathogenicity of amyloid plaques in the context of AD. The ability to longitudinally image plaques and related structures facilitates the evaluation of therapeutic approaches targeting toward the clearance of plaques.
Dong
Jinghui
J
Department of Neuroscience, Tufts University School of Medicine, Boston, MA 02111, USA. jinghui.dong@tufts.edu
Revilla-Sanchez
Raquel
R
Moss
Stephen
S
Haydon
Philip G
PG
D000544:Alzheimer Disease / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology*; D000682:Amyloid / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D036641:Microscopy, Fluorescence, Multiphoton / Q000379:methods
D000682:Amyloid
Neuropsychologia. 2008;46(6):1636-41
18468648
Nature. 1999 Jul 8;400(6740):173-7
10408445
J Cereb Blood Flow Metab. 2002 Sep;22(9):1035-41
12218409
J Neurosci. 2008 Dec 24;28(52):14156-64
19109498
Methods Mol Biol. 2005;299:349-63
15980616
Nature. 2004 Sep 9;431(7005):195-9
15356633
Science. 2005 May 27;308(5726):1314-8
15831717
Neurobiol Aging. 2004 May-Jun;25(5):663-74
15172746
Ann Neurol. 1991 Oct;30(4):572-80
1789684
Nature. 2000 Dec 21-28;408(6815):979-82
11140685
J Neurosci. 1992 Feb;12(2):376-89
1346802
Acta Neuropathol. 2009 Jul;118(1):5-36
19381658
Ann Neurol. 2000 Apr;47(4):430-9
10762153
Nat Med. 2001 Mar;7(3):369-72
11231639
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):4012-7
19228947
Science. 2002 Oct 25;298(5594):789-91
12399581
Neurobiol Dis. 2009 Feb;33(2):213-20
19028582
Ann Neurol. 1984 Sep;16(3):321-9
6385824
Ann N Y Acad Sci. 2007 Feb;1097:40-50
17413008
Int Rev Neurobiol. 2009;84:133-49
19501716
J Neurosci. 2002 Sep 15;22(18):7873-8
12223540
J Neurosci. 2004 Jan 14;24(2):565-75
14724257
Nat Cell Biol. 2003 Dec;5(12):1041-3
14647298
Neurobiol Aging. 2004 May-Jun;25(5):675-83
15172747
J Neurosci. 2005 Oct 26;25(43):10041-8
16251453
Prog Neurobiol. 2002 Aug;67(5):393-420
12234501
Neurology. 1975 Feb;25(2):120-6
46597
Nat Med. 2000 Aug;6(8):916-9
10932230
Neuromolecular Med. 2004;6(1):65-78
15781977
J Neurosci. 2009 Aug 26;29(34):10706-14
19710322
Nature. 2008 Feb 7;451(7179):720-4
18256671
Neuroimaging Clin N Am. 2005 Nov;15(4):755-65, ix
16443488
Science. 2008 Sep 19;321(5896):1686-9
18802001
J Neurosci. 2006 Jan 11;26(2):365-71
16407531
J Neuropathol Exp Neurol. 2005 Jul;64(7):588-94
16042310
Dev Neurobiol. 2008 May;68(6):771-8
18383548
Annu Rev Physiol. 2009;71:261-82
19575680
J Neurosci. 2008 Apr 16;28(16):4283-92
18417708
Neuroscientist. 2002 Oct;8(5):386-90
12374422
Nature. 2000 Dec 21-28;408(6815):982-5
11140686
Nat Neurosci. 2006 Feb;9(2):260-7
16388306
Neurology. 1984 Jun;34(6):730-5
6539433
Neurobiol Dis. 2006 Dec;24(3):516-24
17029828
Ann N Y Acad Sci. 2007 Feb;1097:12-29
17413006
Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12462-7
14517353
J Gen Physiol. 2006 Dec;128(6):637-47
17101816
Nat Med. 2005 May;11(5):556-61
15834427
Stroke. 1987 Mar-Apr;18(2):311-24
3551211
Neurobiol Dis. 2002 Nov;11(2):315-29
12505424
J Neurosci. 2005 Aug 3;25(31):7278-87
16079410
Nat Protoc. 2009;4(8):1128-44
19617885
Chem Pharm Bull (Tokyo). 2009 Oct;57(10):1029-39
19801854
Proc Natl Acad Sci U S A. 1999 Apr 27;96(9):5274-9
10220456
Nat Neurosci. 2004 Nov;7(11):1181-3
15475950
J Neurosci. 2007 Feb 21;27(8):1973-80
17314293
Ann N Y Acad Sci. 1994 Dec 15;747:1-11
7847664
Trends Neurosci. 1993 Oct;16(10):409-14
7504356
J Neuropathol Exp Neurol. 2002 Sep;61(9):797-805
12230326
Am J Pathol. 2007 Oct;171(4):1304-11
17717139
Nat Biotechnol. 2005 May;23(5):577-83
15834405
Science. 2009 Feb 27;323(5918):1211-5
19251629
Ann Neurol. 1990 May;27(5):457-64
2360787
Neuroscientist. 2007 Feb;13(1):38-48
17229974
J Am Chem Soc. 2009 Oct 28;131(42):15257-61
19807070
Arch Pathol. 1959 Nov;68:487-98
13841452
Nat Neurosci. 2007 May;10(5):549-51
17417634
Nat Rev Mol Cell Biol. 2003 Jul;4(7):517-29
12838335
Nat Neurosci. 2003 Jan;6(1):43-50
12469126
J Neurosci. 2007 Oct 3;27(40):10674-84
17913901
Neurobiol Aging. 2001 Jan-Feb;22(1):49-61
11164276
Ann Neurol. 1993 Feb;33(2):190-9
8434881
J Biol Chem. 2004 Nov 5;279(45):46363-6
15385542
Ann N Y Acad Sci. 2007 Feb;1097:30-9
17413007
Nat Neurosci. 2005 Jun;8(6):752-8
15895084
J Mol Neurosci. 2002 Aug-Oct;19(1-2):7-10
12212796
Nat Neurosci. 2005 Apr;8(4):527-33
15768036
Ann N Y Acad Sci. 1997 Sep 26;826:242-7
9329695
Stain Technol. 1988 Jul;63(4):201-12
2464206
J Alzheimers Dis. 2006;9(3 Suppl):401-7
16914878
Cerebrovasc Dis. 2002;13 Suppl 2:42-7
11901242
Eur J Nucl Med Mol Imaging. 2008 Mar;35 Suppl 1:S93-8
18236039
J Clin Invest. 2005 Feb;115(2):428-33
15668737
J Neurosci. 2007 Jan 24;27(4):796-807
17251419
Cell Calcium. 2003 Oct-Nov;34(4-5):385-97
12909083
J Neurosci. 1995 Sep;15(9):6239-49
7666206
Neuron. 2008 Jul 31;59(2):214-25
18667150
Biochim Biophys Acta. 2004 Dec 6;1742(1-3):81-7
15590058
Curr Alzheimer Res. 2009 Jun;6(3):312-9
19519314