title: Interactions between breast, bone, and brain regulate mineral and skeletal metabolism during lactation.
abstract: Mammalian reproduction requires that nursing mothers transfer large amounts of calcium to their offspring through milk. As a result, lactation is associated with dramatic alterations in bone and mineral metabolism, including reversible bone loss. One theme that has emerged from recent studies examining these adaptations is that the lactating breast actively participates in regulating bone and mineral metabolism. This review will detail our current knowledge of interactions between the breast, skeleton, and hypothalamus during lactation and will consider implications that this reproductive physiology has for the pathophysiology of osteoporosis and breast cancer.
authors.affiliation: Yale University School of Medicine, New Haven, Connecticut, USA. john.wysolmerski@yale.edu
authors.forename: John J
authors.initials: JJ
authors.lastname: Wysolmerski
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism / Q000502:physiology*; D001921:Brain / Q000378:metabolism / Q000502:physiology*; D001940:Breast / Q000378:metabolism / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D005260:Female; D006801:Humans; D007774:Lactation / Q000378:metabolism* / Q000502:physiology; D008903:Minerals / Q000378:metabolism*; D008954:Models, Biological; D015663:Osteoporosis, Postmenopausal / Q000209:etiology / Q000378:metabolism; D014886:Weaning
chemical_list: D008903:Minerals; D002118:Calcium
references.citation: Anat Rec A Discov Mol Cell Evol Biol. 2004 Feb;276(2):143-9
references.pmid: 14752853
references.citation: Clin Cancer Res. 2006 Oct 15;12(20 Pt 2):6213s-6216s
references.pmid: 17062703
references.citation: Obstet Gynecol. 1995 Jul;86(1):26-32
references.pmid: 7784018
references.citation: J Clin Endocrinol Metab. 1998 Feb;83(2):703-7
references.pmid: 9467597
references.citation: Obstet Gynecol. 1999 Jul;94(1):52-6
references.pmid: 10389717
references.citation: Endocrinology. 2000 Dec;141(12):4357-64
references.pmid: 11108243
references.citation: Endocrinology. 2003 Dec;144(12):5521-9
references.pmid: 14500568
references.citation: Endocrinology. 2006 Sep;147(9):4010-21
references.pmid: 16675524
references.citation: Am J Clin Nutr. 1998 Apr;67(4):685-92
references.pmid: 9537615
references.citation: J Mammary Gland Biol Neoplasia. 2002 Jul;7(3):267-76
references.pmid: 12751891
references.citation: Front Neuroendocrinol. 2002 Jul;23(3):225-56
references.pmid: 12127305
references.citation: J Clin Invest. 2003 Nov;112(9):1429-36
references.pmid: 14597768
references.citation: J Bone Miner Res. 1990 Jan;5(1):69-75
references.pmid: 2309581
references.citation: Lancet. 1979 Oct 13;2(8146):769-70
references.pmid: 90862
references.citation: Obstet Gynecol. 1999 Oct;94(4):608-15
references.pmid: 10511368
references.citation: Endocrinology. 1976 Aug;99(2):371-8
references.pmid: 954638
references.citation: Anat Rec (Hoboken). 2007 Jan;290(1):65-73
references.pmid: 17441199
references.citation: J Clin Invest. 2000 Nov;106(10):1203-4
references.pmid: 11086020
references.citation: Osteoporos Int. 2001;12(10):828-34
references.pmid: 11716185
references.citation: Biol Reprod. 2001 Sep;65(3):689-95
references.pmid: 11514329
references.citation: Ann Intern Med. 1993 Mar 1;118(5):337-43
references.pmid: 8430979
references.citation: Bone Miner. 1988 Mar;3(4):293-304
references.pmid: 3228614
references.citation: Endocrinology. 2007 Aug;148(8):3875-86
references.pmid: 17495007
references.citation: Endocr Rev. 1997 Dec;18(6):832-72
references.pmid: 9408745
references.citation: Cell Calcium. 2004 Mar;35(3):217-28
references.pmid: 15200145
references.citation: J Biol Chem. 2008 Sep 5;283(36):24435-47
references.pmid: 18621740
references.citation: Bone. 2006 Jun;38(6):787-93
references.pmid: 16377269
references.citation: JAMA. 1996 Aug 21;276(7):549-54
references.pmid: 8709404
references.citation: Endocrinology. 1980 Dec;107(6):1923-9
references.pmid: 7428698
references.citation: Endocrinology. 2000 Oct;141(10):3696-702
references.pmid: 11014224
references.citation: JAMA. 1993 Jun 23-30;269(24):3130-5
references.pmid: 8505816
references.citation: J Clin Invest. 2004 Feb;113(4):598-608
references.pmid: 14966569
references.citation: Endocrinology. 2007 Dec;148(12):5943-54
references.pmid: 17823248
references.citation: Semin Cell Dev Biol. 2008 Oct;19(5):452-8
references.pmid: 18761098
references.citation: Clin Endocrinol (Oxf). 1995 Sep;43(3):373-82
references.pmid: 7586609
references.citation: J Bone Miner Res. 2002 Nov;17(11):1954-60
references.pmid: 12412802
references.citation: Ann N Y Acad Sci. 1994 Feb 18;709:145-55
references.pmid: 8154698
references.citation: Ann Intern Med. 1996 Sep 1;125(5):360-8
references.pmid: 8702086