Memory T-cell trafficking: new directions for busy commuters.
The immune system is unique in representing a network of interacting cells of enormous complexity and yet being based on single cells travelling around the body. The development of effective and regulated immunity relies upon co-ordinated migration of each cellular component, which is regulated by diverse signals provided by the tissue. Co-ordinated migration is particularly relevant to the recirculation of primed T cells, which, while performing continuous immune surveillance, need to promptly localize to antigenic sites, reside for a time sufficient to carry out their effector function and then efficiently leave the tissue to avoid bystander damage. Recent advances that have helped to clarify a number of key molecular mechanisms underlying the complexity and efficiency of memory T-cell trafficking, including antigen-dependent T-cell trafficking, the regulation of T-cell motility by costimulatory molecules, T-cell migration out of target tissue and fugetaxis, are reviewed in this article.
Marelli-Berg
Federica M
FM
Section of Immunobiology, Division of Infection and Immunity, Department of Medicine, Imperial College London, Hammersmith Hospital Campus, Du Cane Road, London, UK. f.marelli@imperial.ac.uk
Fu
Hongmei
H
Vianello
Fabrizio
F
Tokoyoda
Koji
K
Hamann
Alf
A
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D006801:Humans; D007156:Immunologic Memory / Q000502:physiology*; D007157:Immunologic Surveillance / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology*
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