Heritability of MMPI-2 scales in the UCSF family alcoholism study.
The current study evaluated the heritability of personality traits and psychopathology symptoms assessed by the Minnesota Multiphasic Personality Inventory 2nd Edition (MMPI-2) in a family-based sample selected for alcohol dependence. Participants included 950 probands and 1,204 first-degree relatives recruited for the University of California at San Francisco (UCSF) Family Alcoholism Study. Heritability estimates for MMPI-2 scales ranged from .25 to .49. When alcohol dependence was used as a covariate, heritability estimates remained significant but generally declined. However, when the MMPI-2 scales were used as covariates to estimate the heritability of alcohol dependence, the scales measuring antisocial behavior, depressive symptoms, and addictive behavior led to moderate increases in the heritability of alcohol dependence. This suggests that the scales may explain some of the non-genetic variance in the alcohol dependence diagnosis in this population when used as covariates, and thus may serve to produce a more homogeneous and heritable alcohol-dependence phenotype.
Gizer
Ian R
IR
Department of Genetics and the Bowles Center for Alcohol Studies, University of North Carolina, Chapel Hill, NC 27599-7264, USA. igizer@unc.edu
Seaton-Smith
Kimberley L
KL
Ehlers
Cindy L
CL
Vieten
Cassandra
C
Wilhelmsen
Kirk C
KC
D000293:Adolescent; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics* / Q000523:psychology; D000704:Analysis of Variance; D000987:Antisocial Personality Disorder / Q000175:diagnosis / Q000235:genetics; D016739:Behavior, Addictive / Q000175:diagnosis / Q000235:genetics; D003863:Depression / Q000175:diagnosis / Q000235:genetics; D005190:Family; D005260:Female; D006801:Humans; D008950:MMPI / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012495:San Francisco / Q000453:epidemiology; D055815:Young Adult
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