Functional reorganization induced by endovascular embolization of a cerebral AVM.
We mapped motor function in a patient with a cerebral arteriovenous malformation (AVM) before and after treatment with endovascular embolization. Functional activation using technetium-99m-hexamethylpropyleneamine single photon emission tomography (99mTc-HMPAO-SPECT) demonstrated a redistribution of regional cerebral blood flow (rCBF) that correlated with clinical improvement. Intravascular feeding artery pressure measurements, serial angiography, and challenge with a pharmacological vasodilator enabled us to explore possible mechanisms of functional reorganization.
Marshall
R S
RS
Department of Neurology, Neurological Institute, Columbia-Presbyterian Medical Center, New York, New York 10032, USA.
Hacein-Bey
L
L
Young
W L
WL
Pile-Spellman
J
J
Das
S
S
Perera
G
G
Mohr
J P
JP