Organohalogens in a whale-blubber-supplemented diet affects hepatic retinol and renal tocopherol concentrations in greenland sled dogs (Canis familiaris).
The aim of this study was to examine the plasma, liver, and kidney status of vitamin A (retinol) and vitamin E (alpha-tocopherol) in two groups of Greenland sled dogs (Canis familiaris), with a total number of 16 bitches and 8 pups. The dogs were fed either minke whale (Balaenoptera acuterostrata) blubber (exposed dogs) or uncontaminated (control group) porcine fat for up to 12 to 21 mo of age. The daily intake of 50-200 g whale blubber (mean: 112 g) constituted between 10.4 and 11.7 microg/kg body weight summation operatororganohalogen contaminants (OHC) (or between 4.6 and 6.1 microg/kg body weight summation operatorpolychlorinated biphenyls [PCB]). Retinol was approximately 18% and alpha-tocopherol 22% higher in the diet of the exposed dogs compared to controls. In adipose tissue, mean of SigmaOHC was 92 ng/g lipid weight (lw) and 5005 ng/g lw for all control (n = 12) and exposed dogs (n = 10), respectively. Hepatic retinol correlated negatively with Sigma-dichlorodiphenyldichloroethane (SigmaDDT) and and Sigma-polybrominated diphenyl ethers (SigmaPBDE) for all exposed animals. A negative correlation between kidney alpha-tocopherol and SigmaPCB concentrations was observed, whereas two positive significant correlations were observed between kidney retinol and Sigma-chlordane-related compounds (SigmaCHL) and dieldrin concentrations. Hepatic alpha-tocopherol concentrations were significantly lower in exposed compared to controls, most likely due to a combination by OHC exposure and high dietary intake of unsaturated fatty acids. These results suggest that dietary exposure from OHC may, even at low concentrations, possibly affect retinol and alpha-tocopherol status in Arctic top predators.
Kirkegaard
Maja
M
Research Unit of Environmental Medicine, University of Southern Denmark, Odense, Denmark. majakirkegaard@yahoo.dk
Sonne
Christian
C
Jakobsen
Jette
J
Jenssen
Bjørn Munro
BM
Letcher
Robert J
RJ
Dietz
Rune
R
D000273:Adipose Tissue / Q000737:chemistry*; D000821:Animal Feed; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004032:Diet; D019587:Dietary Supplements; D004285:Dogs; D005260:Female; D006843:Hydrocarbons, Chlorinated / Q000032:analysis / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D018811:Maternal Exposure / Q000009:adverse effects; D050636:Minke Whale; D009930:Organic Chemicals; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced; D014801:Vitamin A / Q000097:blood*; D014810:Vitamin E / Q000097:blood*
D006843:Hydrocarbons, Chlorinated; D009930:Organic Chemicals; D014801:Vitamin A; D014810:Vitamin E