Evaluation of the diagnostic value of a Modified Liquid-Based Cytology using OralCDx Brush in early detection of oral potentially malignant lesions and oral cancer.
OBJECTIVE
To determine diagnostic value of modified Liquid Based Brush Biopsy technique.


METHODS
26 oral premalignant and malignant lesions in 25 patients (12 females; 54.23+/-19.77 years and 13 males; 53.77+/-15.43 years) underwent Modified (Liquid Based) Brush Biopsy and scalpel biopsy simultaneously from the same area.


RESULTS
There were 16 positive and 10 negative brush biopsy results, with no inadequate readings. Histological findings were compatible with oral leukoplakia (n=5) with dysplasia, Oral lichen planus and lichenoid reaction (n=7) (with or without dysplasia) oral squamous cell carcinoma (n=11),verrucous carcinoma (n=1) and granular cell tumors (n=2). Sensitivity, specificity, positive predictive value, negative predictive value, positive diagnostic likelihood ratio (LR+) and negative diagnostic likelihood ratio (LR-) were 88.8%, 100%, 100%, 80%, infinity and 0.11 respectively (no false positive results).


CONCLUSIONS
It is the first attempt to do LBC with a specialized oral brush. Our results show that modified technique is a useful tool for screening of oral premalignant and malignant lesions.
Delavarian
Zahra
Z
Dental Research Center of Mashhad Dental School, Mashhad University of Medical Sciences, Mashhad, Khorasane Razavi State, Iran.
Mohtasham
Nooshin
N
Mosannen-Mozafari
Pegah
P
Pakfetrat
Atessa
A
Shakeri
Mohammad-Taghi
MT
Ghafoorian-Maddah
Rasoul
R
D000328:Adult; D000368:Aged; D001706:Biopsy / Q000379:methods; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology*; D055815:Young Adult