title: Noninvasive methods of measuring bone blood perfusion.
abstract: Measurement of bone blood flow and perfusion characteristics in a noninvasive and serial manner would be advantageous in assessing revascularization after trauma and the possible risk of avascular necrosis. Many disease states, including osteoporosis, osteoarthritis, and bone neoplasms, result in disturbed bone perfusion. A causal link between bone perfusion and remodeling has shown its importance in sustained healing and regrowth following injury. Measurement of perfusion and permeability within the bone was performed with small and macromolecular contrast media, using dynamic contrast-enhanced magnetic resonance imaging in models of osteoarthritis and the femoral head. Bone blood flow and remodeling was estimated using (18)F-Fluoride positron emission tomography in fracture healing and osteoarthritis. Multimodality assessment of bone blood flow, permeability, and remodeling by using noninvasive imaging techniques may provide information essential in monitoring subsequent rates of healing and response to treatment as well as identifying candidates for additional therapeutic or surgical interventions.
authors.affiliation: Department of Radiology, Weill Medical College of Cornell University, New York, NY, USA. jpd2001@med.cornell.edu
authors.forename: J P
authors.initials: JP
authors.lastname: Dyke
authors.forename: R K
authors.initials: RK
authors.lastname: Aaron
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000378:metabolism; D003287:Contrast Media / Q000493:pharmacokinetics; D006801:Humans; D018810:Magnetic Resonance Angiography / Q000379:methods*; D055420:Perfusion Imaging / Q000379:methods*; D049268:Positron-Emission Tomography / Q000379:methods; D011859:Radiography; D012039:Regional Blood Flow / Q000502:physiology
chemical_list: D003287:Contrast Media
references.citation: Magn Reson Imaging. 1999 Feb;17(2):237-45
references.pmid: 10215479
references.citation: Bone. 2009 Oct;45(4):711-5
references.pmid: 19555783
references.citation: J Am Acad Orthop Surg. 2001 Jan-Feb;9(1):9-17
references.pmid: 11174159
references.citation: Osteoarthritis Cartilage. 2007 Jun;15(6):673-81
references.pmid: 17336549
references.citation: Radiology. 1997 Sep;204(3):825-32
references.pmid: 9280267
references.citation: J Nucl Med. 2001 Jul;42(7):1091-100
references.pmid: 11438633
references.citation: J Nucl Med. 1992 May;33(5):633-42
references.pmid: 1569473
references.citation: Eur J Nucl Med. 1999 Jun;26(6):615-24
references.pmid: 10369947
references.citation: J Nucl Med. 2008 Jan;49(1):68-78
references.pmid: 18077529
references.citation: J Bone Joint Surg Br. 2009 Jan;91(1):131-7
references.pmid: 19092018
references.citation: J Cereb Blood Flow Metab. 1983 Mar;3(1):1-7
references.pmid: 6822610
references.citation: Bone. 2009 Nov;45(5):942-8
references.pmid: 19660584
references.citation: J Bone Miner Res. 2008 Jul;23(7):1068-75
references.pmid: 18302498
references.citation: J Magn Reson Imaging. 2007 Feb;25(2):390-409
references.pmid: 17260403
references.citation: Osteoarthritis Cartilage. 2009 Oct;17(10):1350-5
references.pmid: 19409292
references.citation: Ann N Y Acad Sci. 2007 Nov;1117:124-37
references.pmid: 18056039
references.citation: J Bone Joint Surg Am. 2006 Nov;88 Suppl 3:4-9
references.pmid: 17079361
references.citation: J Magn Reson Imaging. 1997 Jan-Feb;7(1):91-101
references.pmid: 9039598
references.citation: Orthop Clin North Am. 2009 Apr;40(2):249-57
references.pmid: 19358910
references.citation: J Magn Reson Imaging. 1999 Sep;10(3):223-32
references.pmid: 10508281