The cortical timeline for deciding on reach motor goals.
Flexible sensorimotor planning is the basis for goal-directed behavior. We investigated the integration of visuospatial information with context-specific transformation rules during reach planning. We were especially interested in the relative timing of motor-goal decisions in monkey dorsal premotor cortex (PMd) and parietal reach region (PRR). We used a rule-based mapping task with different cueing conditions to compare task-dependent motor-goal latencies. The task allowed us a separation of cue-related from motor-related activity, and a separation of activity related to motor planning from activity related to motor initiation or execution. The results show that selectivity for the visuospatial goal of a pending movement occurred earlier in PMd than PRR whenever the task required spatial remapping. Such remapping was needed if the spatial representation of a cue or of a default motor plan had to be transformed into a spatially incongruent representation of the motor goal. In contrast, we did not find frontoparietal latency differences if the spatial representation of the cue or the default plan was spatially congruent with the motor goal. The fact that frontoparietal latency differences occurred only in conditions with spatial remapping was independent of the subjects' partial a priori knowledge about the pending goal. Importantly, frontoparietal latency differences existed for motor-goal representations during movement planning, without immediate motor execution. We interpret our findings as being in support of the hypothesis that latency differences reflect a dynamic reorganization of network activity in PRR, and suggest that the reorganization is contingent on frontoparietal projections from PMd.
Westendorff
Stephanie
S
Bernstein Center for Computational Neuroscience, German Primate Center-Leibniz Institute for Primate Research, 37077 Göttingen, Germany.
Klaes
Christian
C
Gail
Alexander
A
D000200:Action Potentials; D000818:Animals; D001132:Arm; D003463:Cues; D003657:Decision Making / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology*; D006040:Goals; D008253:Macaca mulatta; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology*; D010296:Parietal Lobe / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time; D013028:Space Perception / Q000502:physiology; D013997:Time Factors; D014796:Visual Perception / Q000502:physiology
Science. 2009 May 8;324(5928):811-3
19423830
Exp Brain Res. 2008 Mar;185(3):359-81
18251019
Nat Neurosci. 1998 Oct;1(6):529-33
10196553
Cereb Cortex. 2000 Nov;10(11):1093-104
11053230
Brain. 1970;93(4):793-820
4992433
Neuropsychologia. 1991;29(6):517-37
1944859
Nature. 2000 Nov 23;408(6811):466-70
11100727
J Neurosci. 1982 Nov;2(11):1527-37
7143039
J Neurosci. 1991 Jun;11(6):1855-72
2045890
Exp Brain Res. 2000 Jul;133(1):103-13
10933215
J Neurophysiol. 1986 Dec;56(6):1680-702
3806186
Nature. 1994 Oct 13;371(6498):600-2
7935791
J Neurophysiol. 1989 Mar;61(3):534-49
2709098
J Neurosci. 2003 Nov 19;23(33):10540-7
14627638
Neuropsychologia. 2006;44(13):2594-606
16300804
J Neurophysiol. 1996 Dec;76(6):4040-55
8985899
J Neurosci. 2002 May 1;22(9):3683-91
11978844
Science. 1992 Mar 20;255(5051):1517-23
1549781
J Neurosci. 2008 Oct 8;28(41):10287-97
18842888
Brain Res. 1969 Mar;13(1):13-36
4185124
Nat Neurosci. 1999 Jun;2(6):563-7
10448222
Exp Brain Res. 1983;51(2):247-60
6617794
J Neurosci. 1993 Mar;13(3):1227-43
8441009
J Neurosci. 2009 Jul 29;29(30):9490-9
19641112
Philos Trans R Soc Lond B Biol Sci. 2007 Sep 29;362(1485):1585-99
17428779
J Neurosci. 2004 Feb 4;24(5):1113-8
14762129
Exp Brain Res. 1985;58(1):144-53
3987845
J Neurophysiol. 2003 Sep;90(3):1790-806
12736235
Can J Physiol Pharmacol. 1996 Apr;74(4):469-82
8828893
Annu Rev Neurosci. 1997;20:25-42
9056706
Brain Res. 1991 Feb 1;540(1-2):131-7
2054605
J Neurosci. 2007 Sep 26;27(39):10588-96
17898230
Eur J Neurosci. 1999 Sep;11(9):3339-45
10510199
Neuron. 2004 Jun 24;42(6):1003-12
15207244
Exp Brain Res. 1993;95(1):28-40
8405252
J Neurosci. 1997 Mar 15;17(6):2227-46
9045746
Brain Res. 1979 Aug 31;172(3):427-37
113049
Brain Res. 1973 Dec 21;64:85-102
4360893
Cereb Cortex. 1996 Mar-Apr;6(2):102-19
8670643
J Neurophysiol. 1975 Jul;38(4):871-908
808592
Curr Opin Neurobiol. 1997 Dec;7(6):849-59
9464979
J Neurosci. 2006 Sep 13;26(37):9376-84
16971521
Neuron. 2008 Feb 28;57(4):614-25
18304489
Neurosci Res. 1991 Oct;12(1):263-80
1721118
Nature. 2008 May 15;453(7193):406-9
18418380
J Neurosci. 2006 Sep 20;26(38):9761-70
16988047
Cereb Cortex. 2001 Jun;11(6):513-27
11375913
J Neurosci. 2008 Nov 26;28(48):12913-26
19036985
Cereb Cortex. 2003 Oct;13(10):1009-22
12967918
Science. 1996 Sep 13;273(5281):1564-8
8703221
J Neurophysiol. 1994 Mar;71(3):1281-4
8201421
Exp Brain Res. 2002 Jul;145(1):91-103
12070749
Can J Physiol Pharmacol. 1996 Apr;74(4):483-98
8828894
J Neurophysiol. 2000 Aug;84(2):986-1005
10938322
J Neurophysiol. 1995 Jan;73(1):373-86
7714579