title: Simultaneous Estimation of Esomeprazole and Domperidone by UV Spectrophotometric Method.
abstract: A novel, simple, sensitive and rapid spectrophotometric method has been developed for simultaneous estimation of esomeprazole and domperidone. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 301 nm and 284 nm, lambda max of esomeprazole and domperidone respectively. Beer's law was obeyed in the concentration range of 5-20 mug/ml and 8-30 mug/ml for esomeprazole and domperidone respectively. The method was found to be precise, accurate, and specific. The proposed method was successfully applied to estimation of esomeprazole and domperidone in combined solid dosage form.
authors.affiliation: Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal - 576 104, India.
authors.forename: S Lakshmana
authors.initials: SL
authors.lastname: Prabu
authors.forename: A
authors.initials: A
authors.lastname: Shirwaikar
authors.forename: Annie
authors.initials: A
authors.lastname: Shirwaikar
authors.forename: C Dinesh
authors.initials: CD
authors.lastname: Kumar
authors.forename: A
authors.initials: A
authors.lastname: Joseph
authors.forename: R
authors.initials: R
authors.lastname: Kumar
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