Comparison of effects of simvastatin versus atorvastatin on oxidative stress in patients with coronary heart disease.
BACKGROUND
HMG-CoA reductase inhibitors (statins) have antiatherogenic effects beyond their cholesterol-lowing effect. Whether atorvastatin has a stronger antioxidant effect than other statins is uncertain.


OBJECTIVE
To determine the effects of simvastatin and atorvastatin on markers of oxidative stress in patients with coronary heart disease (CHD).


METHODS
This study was comprised of 164 patients with CHD and a control population of 122 healthy subjects. The patients with CHD were divided into 2 groups and treated with either simvastatin 20 mg/day or atorvastatin 10 mg/day. The markers of oxidative stress were measured before and after 12 weeks of treatment.


RESULTS
The effects of atorvastatin on reducing oxidative stress were significantly greater compared with those of simvastatin (P < 0.05). The changes in the markers of oxidative stress did not correlate with the changes in the plasma lipid profile (P > 0.05).


CONCLUSIONS
This study suggests that atorvastatin reduces oxidative stress more effectively than simvastatin.
Li
Jia
J
Department of Cardiac Care Unit, The First Affiliated Hospital of Harbin Medical University, Harbin, China. wlfeng@hotmail.com
Sun
Yan-Ming
YM
Wang
Lan-Feng
LF
Li
Zhu-Qin
ZQ
Pan
Wei
W
Cao
Hong-Yan
HY
D000368:Aged; D000704:Analysis of Variance; D000069059:Atorvastatin; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology*; D018752:Diet, Fat-Restricted; D005260:Female; D005978:Glutathione / Q000097:blood; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008111:Liver Function Tests; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D011446:Prospective Studies; D011758:Pyrroles / Q000627:therapeutic use*; D019821:Simvastatin / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000097:blood; D016896:Treatment Outcome
D015415:Biomarkers; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D008315:Malondialdehyde; D000069059:Atorvastatin; D019821:Simvastatin; D013482:Superoxide Dismutase; D005978:Glutathione
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