title: Psychobiological differences between depression and somatization.
abstract: BACKGROUND
  Comorbidity studies have shown that depression and somatization (multiple somatoform symptoms) often overlap. Therefore it has been suggested to classify at least some patients with somatization syndromes under the category of depressive disorders. We wanted to investigate whether psychobiological investigations confirm the lumping of somatization and depression, or whether psychobiological pathways favor distinguishing these disorders.
  
  
  METHODS
  An overview is presented summarizing psychobiological studies including patients with depression and/or somatization-associated syndromes. We focus on the following topics: heritability, polymorphisms in special candidate genes, immune activation, hypothalamic-pituitary-adrenal (HPA) axis reactivity, serotonergic pathways, monoamino acids, and fatty acid concentrations.
  
  
  RESULTS
  Immunological activation seems to be associated with specific features of somatoform disorders, namely, sickness behavior and pain thresholds. Genetic factors can also contribute to somatic complaints, e.g., via serotonergic pathways, HPA-axis response, immune activation, and other biological systems that contribute to the self-description of not being healthy. Some results indicate that psychobiological aspects of depression and somatization overlap in part (e.g., the relevance of serotonergic pathways), but there is clearly more evidence for discrepancies of psychobiological pathways in depression and somatization (e.g., the relevance of proinflammatory immune processes; HPA-axis activity; monoamino acid availability; omega-3-concentration; the role of triallelic subtypes of 5-HTTLPR).
  
  
  CONCLUSIONS
  Many psychobiological pathways act differently in depression and somatization. These differences in psychobiology favor the distinction of these syndromes in classification approaches.
authors.affiliation: Division of Clinical Psychology and Psychotherapy, University of Marburg, D-35032 Marburg, Germany. rief@staff.uni-marburg.de
authors.forename: Winfried
authors.initials: W
authors.lastname: Rief
authors.forename: Anika
authors.initials: A
authors.lastname: Hennings
authors.forename: Sabine
authors.initials: S
authors.lastname: Riemer
authors.forename: Frank
authors.initials: F
authors.lastname: Euteneuer
mesh_terms: D003866:Depressive Disorder / Q000235:genetics / Q000276:immunology / Q000523:psychology*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000276:immunology; D055809:Illness Behavior; D010913:Pituitary-Adrenal System / Q000276:immunology; D011602:Psychophysiologic Disorders / Q000235:genetics / Q000276:immunology / Q000523:psychology*; D012701:Serotonin / Q000276:immunology; D013001:Somatoform Disorders / Q000235:genetics / Q000276:immunology / Q000523:psychology*
chemical_list: D012701:Serotonin