Genome-wide association study of bipolar I disorder in the Han Chinese population.
We report the first genome-wide association study in 1000 bipolar I patients and 1000 controls, with a replication of the top hits in another 409 cases and 1000 controls in the Han Chinese population. Four regions with most strongly associated single-nucleotide polymorphisms (SNPs) were detected, of which three were not found in previous GWA studies in the Caucasian populations. Among them, SNPs close to specificity protein 8 (SP8) and ST8 α-N-acetyl- neuraminide α-2,8-sialyltransferase (ST8SIA2) are associated with Bipolar I, with P-values of 4.87 × 10(-7) (rs2709736) and 6.05 × 10(-6) (rs8040009), respectively. We have also identified SNPs in potassium channel tetramerization domain containing 12 gene (KCTD12) (rs2073831, P=9.74 × 10(-6)) and in CACNB2 (Calcium channel, voltage-dependent, β-2 subunit) gene (rs11013860, P=5.15 × 10(-5)), One SNP nearby the rs1938526 SNP of ANK3 gene and another SNP nearby the SNP rs11720452 in chromosome 3 reported in previous GWA studies also showed suggestive association in this study (P=6.55 × 10(-5) and P=1.48 × 10(-5), respectively). This may suggest that there are common and population-specific susceptibility genes for bipolar I disorder.
Lee
M T M
MT
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
Chen
C H
CH
Lee
C S
CS
Chen
C C
CC
Chong
M Y
MY
Ouyang
W C
WC
Chiu
N Y
NY
Chuo
L J
LJ
Chen
C Y
CY
Tan
H K L
HK
Lane
H Y
HY
Chang
T J
TJ
Lin
C H
CH
Jou
S H
SH
Hou
Y M
YM
Feng
J
J
Lai
T J
TJ
Tung
C L
CL
Chen
T J
TJ
Chang
C J
CJ
Lung
F W
FW
Chen
C K
CK
Shiah
I S
IS
Liu
C Y
CY
Teng
P R
PR
Chen
K H
KH
Shen
L J
LJ
Cheng
C S
CS
Chang
T P
TP
Li
C F
CF
Chou
C H
CH
Chen
C Y
CY
Wang
K H T
KH
Fann
C S J
CS
Wu
J Y
JY
Chen
Y T
YT
Cheng
A T A
AT
D017487:Ankyrins / Q000235:genetics; D044466:Asian People / Q000208:ethnology / Q000235:genetics; D001714:Bipolar Disorder / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D020746:Calcium Channels, L-Type / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011506:Proteins / Q000235:genetics; D015203:Reproducibility of Results; D012799:Sialyltransferases / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D017487:Ankyrins; D020746:Calcium Channels, L-Type; D004268:DNA-Binding Proteins; D011506:Proteins; D012799:Sialyltransferases; D014157:Transcription Factors; C490613:ANK3 protein, human; C107597:CACNB2 protein, human; C493175:KCTD12 protein, human; C501901:SP8 protein, human; C046778:CMP-N-acetylneuraminate-poly-alpha-2,8-sialosyl sialyltransferase