Selective electrochemical discrimination between dopamine and phenethylamine-derived psychotropic drugs using electrodes modified with an acyclic receptor containing two terminal 3-alkoxy-5-nitroindazole rings.
Electrochemical discrimination between dopamine and psychotropic drugs which have in common a skeletal structure of phenethylamine, can be obtained using acyclic receptors L(1) and L(2), containing two terminal 3-alkoxy-5-nitroindazole rings. Upon attachment to graphite electrodes, L(1) and L(2) exhibit a well-defined, essentially reversible solid state electrochemistry in contact with aqueous media, based on electrolyte-assisted reduction processes involving successive cation and anion insertion/binding. As a result, a distinctive, essentially Nernstian electrochemical response is obtained for phenethylammonium ions of methamphetamine (METH), p-methoxyamphetamine (PMA), amphetamine (AMPH), mescaline (MES), homoveratrylamine (HOM), phenethylamine (PEA) and dopamine (DA) in aqueous media.
Doménech
Antonio
A
Departament de Química Analítica, Universitat de València. Dr Moliner 50, 46100, Burjassot (Valencia), Spain. antonio.domenech@uv.es
Navarro
Pilar
P
Arán
Vicente J
VJ
Muro
Beatriz
B
Montoya
Noemí
N
García-España
Enrique
E
D000661:Amphetamine / Q000737:chemistry; D000662:Amphetamines / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D004298:Dopamine / Q000737:chemistry*; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D007191:Indazoles / Q000737:chemistry*; D008635:Mescaline / Q000737:chemistry; D008694:Methamphetamine / Q000737:chemistry; D010627:Phenethylamines / Q000737:chemistry*; D011619:Psychotropic Drugs / Q000737:chemistry*
D000662:Amphetamines; D007191:Indazoles; D010627:Phenethylamines; D011619:Psychotropic Drugs; C530840:5-nitroindazole; C029261:phenethylamine; D008694:Methamphetamine; D002244:Carbon; D000661:Amphetamine; C100230:4-methoxyamphetamine; D008635:Mescaline; D004298:Dopamine