Proteome analysis of lumbar spinal cord from rats submitted to peripheral lesion during neonatal period.
Every year traumatic peripheral nerve injuries (TPNI) result in considerable physical disability across the world; the mechanisms of plasticity and reorganization of spinal cord circuits following such injuries are complex and not completely understood. A comparative proteome analysis between neonatal rats submitted to peripheral lesion and controls was performed; a number of differentially expressed proteins involved in oxidative stress response, energy metabolism and cytoskeleton rearrangement were revealed, which may support future studies to help in the understanding and a posteriori the treatment of TPNI.
Castro-Dias
Erich
E
Laboratório de Proteômica, Depto de Bioquímica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Rua Monteiro Lobato, s/n, CP 6109, Campinas, SP 13.083-970, Brazil.
Vieira
André S
AS
Werneck
Claudio C
CC
Langone
Francesco
F
Novello
José C
JC
Martins-de-Souza
Daniel
D
D000818:Animals; D000831:Animals, Newborn; D019771:Axotomy / Q000379:methods; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D008159:Lumbar Vertebrae; D010523:Peripheral Nervous System Diseases / Q000378:metabolism* / Q000473:pathology*; D020543:Proteome / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000378:metabolism*
D020543:Proteome
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