A method for evaluation of therapeutic dose of doxorubicin hydrochloride using breast tumor cell culture MCF-7.
Growth kinetics of human breast tumor cell in the presence of doxorubicin was studied using the method of UV spectrophotometery. Parameters of ecotoxicological cell growth model were established. Cell number predicted by the model equation corresponded to the observed cell count within the experimental error. The therapeutic dose of doxorubicin hydrochloride was determined.
Shanskij
Ya D
YD
P A Hertzen Research Institute of Oncology, Federal Agency for High Technology Medical Aid, Russia. dest813@mail.ru
Ershov
Yu A
YA
Pechennikov
V M
VM
D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004317:Doxorubicin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D013056:Spectrophotometry, Ultraviolet
D004317:Doxorubicin