Quantitative genetic analysis suggests causal association between cuticular hydrocarbon composition and desiccation survival in Drosophila melanogaster.
Survival to low relative humidity is a complex adaptation, and many repeated instances of evolution to desiccation have been observed among Drosophila populations and species. One general mechanism for desiccation resistance is Cuticular Hydrocarbon (CHC) melting point. We performed the first Quantitative Trait Locus (QTL) map of population level genetic variation in desiccation resistance in D. melanogaster. Using a panel of Recombinant Inbred Lines (RILs) derived from a single natural population, we mapped QTL in both sexes throughout the genome. We found that in both sexes, CHCs correlated strongly with desiccation resistance. At most desiccation resistance loci there was a significant association between CHCs and desiccation resistance of the sort predicted from clinal patterns of CHC variation and biochemical properties of lipids. This association was much stronger in females than males, perhaps because of greater overall abundance of CHCs in females, or due to correlations between CHCs used for waterproofing and sexual signalling in males. CHC evolution may be a common mechanism for desiccation resistance in D. melanogaster. It will be interesting to compare patterns of CHC variation and desiccation resistance in species which adapt to desiccation, and rainforest restricted species which cannot.
Foley
B R
BR
Department of Biological Sciences, University of Southern California, Los Angeles, CA 90007, USA. bradfole@usc.edu
Telonis-Scott
M
M
D000222:Adaptation, Physiological / Q000235:genetics*; D000818:Animals; D003890:Desiccation; D004331:Drosophila melanogaster / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D005260:Female; D058685:Genetic Pleiotropy; D006838:Hydrocarbons / Q000032:analysis*; D008297:Male; D040641:Quantitative Trait Loci; D013312:Stress, Physiological / Q000235:genetics*
D006838:Hydrocarbons
Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7257-60
11607207
Science. 2009 Sep 4;325(5945):1244-6
19729654
Genetica. 2004 Mar;120(1-3):195-212
15088658
PLoS Genet. 2006 Jul;2(7):e114
16848643
Evolution. 1989 Mar;43(2):468-473
28568563
Evolution. 1993 Aug;47(4):1255-1270
28564275
Curr Opin Plant Biol. 2009 Apr;12(2):241-6
19196544
J Exp Biol. 1997 Jun;200(Pt 12):1821-32
9225453
Evolution. 1998 Oct;52(5):1342-1352
28565385
Genetics. 2003 Feb;163(2):771-87
12618413
Genetics. 2007 Mar;175(3):1465-77
17194783
Nat Rev Genet. 2002 Jan;3(1):43-52
11823790
Dev Biol. 2009 Aug 1;332(1):36-47
19433086
J Exp Biol. 1998 Nov;201(Pt 21):2945-52
9866879
Science. 2003 Dec 5;302(5651):1754-7
14657496
Science. 2003 Jul 4;301(5629):100-2
12843394
J Evol Biol. 2005 Jul;18(4):789-803
16033550
Genet Res. 1996 Jun;67(3):211-8
8690269
Physiol Zool. 1998 Sep-Oct;71(5):584-94
9754535
Heredity (Edinb). 1999 Dec;83 ( Pt 6):637-43
10651907
Genetics. 2005 Apr;169(4):2101-13
15520257
Heredity (Edinb). 2001 Sep;87(Pt 3):363-72
11737283
Genetics. 1989 Aug;122(4):837-45
2503423
Science. 2009 Feb 6;323(5915):746-51
19197055
Insect Mol Biol. 2007 Aug;16(4):435-43
17506850
Evolution. 1998 Jun;52(3):825-831
28565258
J Exp Biol. 2003 Apr;206(Pt 7):1183-92
12604578
Genetica. 2000;110(2):117-30
11678502
Curr Biol. 2007 Mar 20;17(6):528-32
17306541
Hereditas. 1983;99(2):165-75
6421774
J Exp Biol. 2006 May;209(Pt 10):1837-47
16651550
Comp Biochem Physiol A Mol Integr Physiol. 2002 Nov;133(3):781-9
12443934
Nat Genet. 2005 Jul;37(7):710-7
15965475
Am Nat. 2005 Feb;165(2):281-9
15729657
J Exp Biol. 2001 Oct;204(Pt 19):3323-31
11606606
Aging Cell. 2004 Jun;3(3):133-40
15153181