title: Integrating high-throughput technologies in the quest for effective biomarkers for ovarian cancer.
abstract: Despite widespread interest, few serum biomarkers have been introduced to the clinic over the past 20 years. Each approach to ovarian cancer biomarker discovery has its own advantages and disadvantages and it seems likely that a global biomarker discovery platform that mines all possible sources for biomarkers might be more useful. Such data could be combined with information from relevant microarray data, bioinformatic analyses and literature searches. This proposed integrated systems biology approach has the potential to yield promising ovarian cancer markers for diagnosis, prognosis and monitoring of patients during therapy.
authors.affiliation: Vathany Kulasingam, Maria P. Pavlou and Eleftherios P. Diamandis are at the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto M5G 1X5, Ontario, Canada.
authors.forename: Vathany
authors.initials: V
authors.lastname: Kulasingam
authors.forename: Maria P
authors.initials: MP
authors.lastname: Pavlou
authors.forename: Eleftherios P
authors.initials: EP
authors.lastname: Diamandis
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D055088:Early Detection of Cancer / Q000379:methods*; D005260:Female; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D010051:Ovarian Neoplasms / Q000175:diagnosis*
chemical_list: D014408:Biomarkers, Tumor
references.citation: Mol Cell Proteomics. 2002 Nov;1(11):845-67
references.pmid: 12488461
references.citation: Clin Chem. 2009 Jul;55(7):1427-30
references.pmid: 19443560
references.citation: Nat Clin Pract Oncol. 2008 Oct;5(10):577-87
references.pmid: 18648354
references.citation: Oncology. 1989;46(5):318-22
references.pmid: 2779946
references.citation: Clin Chem. 2006 Apr;52(4):771-2; author reply 772
references.pmid: 16595832
references.citation: Lancet. 2002 Feb 16;359(9306):572-7
references.pmid: 11867112
references.citation: Clin Cancer Res. 2007 Jan 15;13(2 Pt 1):458-66
references.pmid: 17255266
references.citation: Gynecol Oncol. 2006 Nov;103(2):405-16
references.pmid: 16725184
references.citation: Gynecol Oncol. 2003 Jan;88(1 Pt 2):S136-9
references.pmid: 12586105
references.citation: Biomark Insights. 2007 Oct 16;2:369-75
references.pmid: 19662218
references.citation: Cancer Res. 2004 Aug 15;64(16):5882-90
references.pmid: 15313933
references.citation: J Mol Med (Berl). 2003 Oct;81(10):600-12
references.pmid: 12928786
references.citation: Clin Biochem. 2010 Mar;43(4-5):355-61
references.pmid: 19883638
references.citation: Lancet Oncol. 2009 Apr;10(4):327-40
references.pmid: 19282241
references.citation: Int J Cancer. 2008 Nov 1;123(9):2007-12
references.pmid: 18712711
references.citation: J Natl Cancer Inst. 2004 Mar 3;96(5):353-6
references.pmid: 14996856
references.citation: Mol Cell Proteomics. 2004 Apr;3(4):367-78
references.pmid: 14990683
references.citation: Br J Cancer. 2009 Apr 21;100(8):1315-9
references.pmid: 19337252
references.citation: Clin Chem. 2005 Aug;51(8):1525-8
references.pmid: 15951319
references.citation: Cancer Res. 2003 Jul 1;63(13):3695-700
references.pmid: 12839961
references.citation: J Proteome Res. 2008 Aug;7(8):3613-8
references.pmid: 18624399
references.citation: Pharmacogenomics. 2005 Sep;6(6):647-53
references.pmid: 16143004
references.citation: J Proteome Res. 2009 Oct;8(10):4705-13
references.pmid: 19663500
references.citation: Nat Rev Cancer. 2007 Sep;7(9):659-72
references.pmid: 17721431
references.citation: Lab Invest. 2007 Aug;87(8):737-54
references.pmid: 17558419
references.citation: J Proteome Res. 2008 Jan;7(1):339-51
references.pmid: 18076136
references.citation: Mol Cell Proteomics. 2004 Apr;3(4):355-66
references.pmid: 14764655
references.citation: Clin Cancer Res. 2003 Jan;9(1):44-51
references.pmid: 12538450
references.citation: Ann Oncol. 2001 Oct;12(10):1353-7
references.pmid: 11762804
references.citation: Nat Biotechnol. 2009 Jul;27(7):633-41
references.pmid: 19561596
references.citation: J Natl Cancer Inst. 2002 Nov 20;94(22):1697-703
references.pmid: 12441325
references.citation: Gynecol Oncol. 2008 Feb;108(2):402-8
references.pmid: 18061248
references.citation: PLoS One. 2009 Nov 19;4(11):e7916
references.pmid: 19936259
references.citation: J Proteome Res. 2007 Dec;6(12):4549-55
references.pmid: 17970587
references.citation: Nat Rev Cancer. 2007 Sep;7(9):645-58
references.pmid: 17687385
references.citation: J Am Coll Surg. 2004 Jun;198(6):999-1011
references.pmid: 15194082
references.citation: Mol Cell Proteomics. 2009 Apr;8(4):661-9
references.pmid: 19047685
references.citation: PLoS One. 2008 Jun 18;3(6):e2425
references.pmid: 18560578
references.citation: Ann Oncol. 1996 Apr;7(4):361-4
references.pmid: 8805927
references.citation: Proteomics. 2002 Jan;2(1):76-84
references.pmid: 11788994
references.citation: Clin Chem. 2005 Sep;51(9):1637-49
references.pmid: 16002455
references.citation: Cancer. 2004 May 15;100(10):2139-47
references.pmid: 15139056
references.citation: Am J Obstet Gynecol. 2008 Sep;199(3):215-23
references.pmid: 18468571
references.citation: Clin Cancer Res. 2008 Feb 15;14(4):1065-72
references.pmid: 18258665
references.citation: J Natl Cancer Inst. 2008 Oct 15;100(20):1432-8
references.pmid: 18840817
references.citation: Nat Biotechnol. 2006 Aug;24(8):971-83
references.pmid: 16900146
references.citation: J Natl Cancer Inst. 2005 Feb 16;97(4):315-9
references.pmid: 15713968
references.citation: CA Cancer J Clin. 2008 Mar-Apr;58(2):71-96
references.pmid: 18287387
references.citation: J Proteome Res. 2007 Apr;6(4):1440-50
references.pmid: 17315909
references.citation: N Engl J Med. 2004 Dec 9;351(24):2519-29
references.pmid: 15590954
references.citation: J Natl Cancer Inst. 2001 Jul 18;93(14):1054-61
references.pmid: 11459866
references.citation: Proc Natl Acad Sci U S A. 2003 Mar 18;100(6):3410-5
references.pmid: 12624183
references.citation: Nature. 2007 Jun 21;447(7147):966-71
references.pmid: 17515920
references.citation: J Clin Oncol. 2004 Dec 1;22(23):4700-10
references.pmid: 15505275
references.citation: Int J Gynaecol Obstet. 2003 Oct;83 Suppl 1:203-9
references.pmid: 14763176
references.citation: Gynecol Oncol. 2009 Jan;112(1):40-6
references.pmid: 18851871
references.citation: BMB Rep. 2008 Sep 30;41(9):626-34
references.pmid: 18823585
references.citation: Curr Opin Chem Biol. 2008 Feb;12(1):72-7
references.pmid: 18295612