Clinical characteristics and outcomes of patients with idiopathic inflammatory myopathies from Jordan 1996-2009.
To describe demographic characteristics, clinical features and outcome of Jordanian patients with idiopathic inflammatory myopathies (IIM), a retrospective chart review of all patients diagnosed with IIM at Jordan University Hospital between 1996 and 2009 was carried out. Thirty patients with IIM were identified. Female to male ratio was 1.7:1, with mean age at diagnosis 34.3 ± 9.2 (10-72) years with bimodal presentation at 21 and 49 years and a mean follow-up of 6.5 ± 5.7 years. Eleven patients had polymyositis (PM); 19 patients had dermatomyositis (DM); 1 patient had DM with malignancy; 2 patients had juvenile DM; and 2 patients had DM/PM with other rheumatologic diseases. Raynaud's phenomenon was present in 26% of patients, dysphagia in 40%, fever in 16%, arthralgia/arthritis in 26%, and dyspnea was present in 26% patients. Positive muscle biopsy and EMG were present in 81% and 92% of patients, respectively. Elevated serum creatinine kinase (CK), AST/ALT and LDH were found in 90%, 72%, and 88% of patients at presentation, respectively. Interstitial fibrosis identified on high-resolution computed tomography (HRCT) was found in 7/14 (50%) patients. Restrictive lung disease was present in 16/21 (76%), low diffusion capacity of lung of carbon monoxide (DLCO) in 10/17 (59%) and pulmonary hypertension in only 3/19 (16%) patients tested. Arab Jordanian patients with IIM showed very low prevalence of malignancy, lower mean age than previous reports, and similar other clinical, laboratory and serologic markers, and survival rate to previous reports. Of interest, we found that extra-muscular manifestations were mainly associated with dermatomyositis.
Mustafa
Khader N
KN
Section of Rheumatology, Department of Internal Medicine, Jordan University Hospital, Queen Rania St, PO Box 13046, 11942 Amman, Jordan. kmustafa@ju.edu.jo
Dahbour
Said S
SS
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007597:Jordan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000175:diagnosis / Q000188:drug therapy / Q000401:mortality*; D011239:Prednisolone / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult
D005938:Glucocorticoids; D011239:Prednisolone
Arthritis Rheum. 2008 May 15;59(5):677-85
18438901
Arthritis Rheum. 1985 Mar;28(3):249-55
3977973
J Rheumatol. 1995 Jul;22(7):1300-3
7562762
J Clin Rheumatol. 2005 Jun;11(3):153-6
16357735
Semin Arthritis Rheum. 2003 Apr;32(5):273-84
12701038
N Engl J Med. 1975 Feb 13;292(7):344-7
1090839
Ann Rheum Dis. 1987 Jan;46(1):23-9
3813671
Arthritis Rheum. 2002 Dec 15;47(6):614-22
12522835
J Rheumatol. 1998 Jul;25(7):1336-43
9676766
Autoimmunity. 2006 May;39(3):205-15
16769654
Clin Rheumatol. 2009 Jun;28(6):639-46
19247576
J Rheumatol. 2009 Dec;36(12):2704-10
19918034
Semin Arthritis Rheum. 1996 Aug;26(1):447-58
8870112
Rev Med Interne. 2009 Sep;30(9):747-53
19683369
Ann N Y Acad Sci. 2005 Jun;1051:64-71
16126945
Ann Rheum Dis. 1993 Dec;52(12):857-61
8311535
Medicine (Baltimore). 1977 Jul;56(4):255-86
327194
Semin Arthritis Rheum. 1998 Apr;27(5):319-24
9572713
J Rheumatol. 2001 Jul;28(7):1591-9
11469467
Ann Intern Med. 2001 Jun 19;134(12):1087-95
11412048
J Rheumatol. 2001 Oct;28(10):2230-7
11669162
Semin Arthritis Rheum. 1990 Oct;20(2):114-20
2251506
Medicine (Baltimore). 2004 Jan;83(1):35-42
14747766
Br J Cancer. 2001 Jul 6;85(1):41-5
11437400
Arch Intern Med. 1985 Oct;145(10):1835-9
3876087
Yonsei Med J. 2006 Aug 31;47(4):519-23
16941742
Rheumatology (Oxford). 2002 Jan;41(1):22-6
11792875
Nihon Kyobu Shikkan Gakkai Zasshi. 1995 Dec;33 Suppl:268-76
8752518
Ann Saudi Med. 1993 Nov;13(6):525-9
17589090
Lancet. 2001 Jan 13;357(9250):96-100
11197446
Eur Rev Med Pharmacol Sci. 2009 Mar-Apr;13(2):77-80
19499841
N Engl J Med. 1978 Apr 27;298(17):934-9
642974
Can Med Assoc J. 1985 Mar 15;132(6):649-53
3872156
N Engl J Med. 1991 Nov 21;325(21):1487-98
1658649
Clin Exp Rheumatol. 1996 May-Jun;14(3):263-74
8809440
J Rheumatol. 2008 Mar;35(3):438-44
18203322
Semin Arthritis Rheum. 1986 Feb;15(3):168-78
3515559
N Engl J Med. 1992 Feb 6;326(6):363-7
1729618
Rheumatology (Oxford). 2005 Oct;44(10):1282-6
15972351
N Engl J Med. 1975 Feb 20;292(8):403-7
1089199
J Assoc Physicians India. 2002 Oct;50:1255-8
12568209
Intern Med J. 2005 Mar;35(3):170-3
15737137