Molecular networks in respiratory epithelium carcinomas.
Current anti-cancer research is focused on cell surface receptors targeting, mainly epidermal growth factor receptor and vascular endothelial growth factor receptor, against which a few targeted agents are now available in clinical practice. Recent improvements of our understanding on the intracellular networks that participate in respiratory epithelium carcinogenesis have further elucidated the role of a variety of molecules that represent attractive targets for novel therapeutic strategies. The aim of this review is to explore the potential therapeutic opportunities of the manipulation of these pathways.
Pallis
Athanasios G
AG
Department of Biological Chemistry, Medical School, University of Athens, Athens, Greece.
Karamouzis
Michalis V
MV
Konstantinopoulos
Panagiotis A
PA
Papavassiliou
Athanasios G
AG
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002471:Cell Transformation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D053858:Metabolic Networks and Pathways; D011956:Receptors, Cell Surface / Q000378:metabolism*; D020545:Respiratory Mucosa / Q000378:metabolism*; D012142:Respiratory Tract Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction
D000970:Antineoplastic Agents; D011956:Receptors, Cell Surface