D-cycloserine in prelimbic cortex enhances relearning of an odor-reward associative task.
We investigated the effects of bilateral infusions in the prelimbic cortex of D-cycloserine (DCS), a partial agonist of the NMDA receptor-associated glycine site. Wistar rats underwent a training session (acquisition, three trials) and a 24-h test (two retention and two relearning trials) of a rapidly learned olfactory discrimination task. Rats infused with DCS (10 microg/site) prior to training exhibited a significant enhancement of performance in such odor-reward task, especially in relearning.
Villarejo-Rodríguez
Irene
I
Departament de Psicobiologia i Metodologia de les Ciències de la Salut, Institut de Neurociències, Universitat Autònoma de Barcelona, Barcelona, Spain.
Vale-Martínez
Anna
A
Guillazo-Blanch
Gemma
G
Martí-Nicolovius
Margarita
M
D000704:Analysis of Variance; D000818:Animals; D001245:Association Learning / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects*; D003523:Cycloserine / Q000494:pharmacology*; D004192:Discrimination, Psychological / Q000187:drug effects; D018683:Excitatory Amino Acid Agents / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects; D009483:Neuropsychological Tests; D009812:Odorants; D055696:Olfactory Perception / Q000187:drug effects*; D010812:Physical Stimulation; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists / Q000378:metabolism; D012201:Reward; D013997:Time Factors
D018683:Excitatory Amino Acid Agents; D016194:Receptors, N-Methyl-D-Aspartate; D003523:Cycloserine