Correction of endothelial dysfunction with impaza preparation in complex with enalapril and losartan during modeling of NO deficiency.
Modeling of NO deficiency by administration of L-NAME to rats led to the development of arterial hypertension and endothelial dysfunction. Pronounced endothelium and cardioprotective effects of impaza under these experimental conditions manifested more markedly during combined administration of the preparation with standard hypotensive preparations enalapril and losartan.
Belous
A S
AS
Kursk State Medical University, Federal Agency for Health Care and Social Development.
Pokrovskii
M V
MV
Pokrovskaya
T G
TG
Kochkarov
V I
VI
Artyushkova
E B
EB
Pashin
E N
EN
Zhavbert
E S
ES
D000818:Animals; D000906:Antibodies / Q000627:therapeutic use*; D004656:Enalapril / Q000627:therapeutic use*; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D019808:Losartan / Q000627:therapeutic use*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000172:deficiency*; D051381:Rats; D017208:Rats, Wistar
D000906:Antibodies; C534505:IMPAZA; D009569:Nitric Oxide; D004656:Enalapril; D019808:Losartan; D019331:NG-Nitroarginine Methyl Ester