title: Proteome analysis of lumbar spinal cord from rats submitted to peripheral lesion during neonatal period.
abstract: Every year traumatic peripheral nerve injuries (TPNI) result in considerable physical disability across the world; the mechanisms of plasticity and reorganization of spinal cord circuits following such injuries are complex and not completely understood. A comparative proteome analysis between neonatal rats submitted to peripheral lesion and controls was performed; a number of differentially expressed proteins involved in oxidative stress response, energy metabolism and cytoskeleton rearrangement were revealed, which may support future studies to help in the understanding and a posteriori the treatment of TPNI.
authors.affiliation: Laboratório de Proteômica, Depto de Bioquímica, Instituto de Biologia, Universidade Estadual de Campinas (UNICAMP), Rua Monteiro Lobato, s/n, CP 6109, Campinas, SP 13.083-970, Brazil.
authors.forename: Erich
authors.initials: E
authors.lastname: Castro-Dias
authors.forename: André S
authors.initials: AS
authors.lastname: Vieira
authors.forename: Claudio C
authors.initials: CC
authors.lastname: Werneck
authors.forename: Francesco
authors.initials: F
authors.lastname: Langone
authors.forename: José C
authors.initials: JC
authors.lastname: Novello
authors.forename: Daniel
authors.initials: D
authors.lastname: Martins-de-Souza
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D019771:Axotomy / Q000379:methods; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D008159:Lumbar Vertebrae; D010523:Peripheral Nervous System Diseases / Q000378:metabolism* / Q000473:pathology*; D020543:Proteome / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000378:metabolism*
chemical_list: D020543:Proteome
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