title: Bionanosphere lithography via hierarchical peptide self-assembly of aromatic triphenylalanine.
abstract: A nanolithographic approach based on hierarchical peptide self-assembly is presented. An aromatic peptide of N-(t-Boc)-terminated triphenylalanine is designed from a structural motif for the beta-amyloid associated with Alzheimer's disease. This peptide adopts a turnlike conformation with three phenyl rings oriented outward, which mediate intermolecular pi-pi stacking interactions and eventually facilitate highly crystalline bionanosphere assembly with both thermal and chemical stability. The self-assembled bionanospheres spontaneously pack into a hexagonal monolayer at the evaporating solvent edge, constituting evaporation-induced hierarchical self-assembly. Metal nanoparticle arrays or embossed Si nanoposts could be successfully created from the hexagonal bionanosphere array masks in conjunction with a conventional metal-evaporation or etching process. Our approach represents a bionanofabrication concept that biomolecular self-assembly is hierarchically directed to establish a straightforward nanolithography compatible with conventional device-fabrication processes.
authors.affiliation: Soft Nanomaterials National Research Laboratory Department of Materials Science and Engineering KAIST, Daejeon 305-701, Republic of Korea.
authors.forename: Tae Hee
authors.initials: TH
authors.lastname: Han
authors.forename: Taedong
authors.initials: T
authors.lastname: Ok
authors.forename: Jangbae
authors.initials: J
authors.lastname: Kim
authors.forename: Dong Ok
authors.initials: DO
authors.lastname: Shin
authors.forename: Hyotcherl
authors.initials: H
authors.lastname: Ihee
authors.forename: Hee-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Sang Ouk
authors.initials: SO
authors.lastname: Kim
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D054118:Nanospheres / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013818:Thermogravimetry; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; C551987:N-(t-butyloxycarbonyl)-protected triphenylalanine; D010455:Peptides; D010649:Phenylalanine