title: Role of hematopoietic cells in the maintenance of chronic human torquetenovirus plasma viremia.
abstract: Many aspects of the life cycle of torquetenoviruses (TTVs) are essentially unexplored. In particular, it is still a matter of speculation which cell type(s) replicates the viruses and maintains the generally high viral loads found in the blood of infected hosts. In this study, we sequentially measured the TTV loads in the plasma of four TTV-positive leukemia patients who were strongly myelosuppressed and then transplanted with haploidentical hematopoietic stem cells. The findings provide clear quantitative evidence for an extremely important role of hematopoietic cells in the maintenance of TTV viremia.
authors.affiliation: Virology Section and Retrovirus Centre, Department of Experimental Pathology, University of Pisa, Italy, Via San Zeno, 35-37, 56127 Pisa, Italy. maggif@biomed.unipi.it
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Maggi
authors.forename: Daniele
authors.initials: D
authors.lastname: Focosi
authors.forename: Melania
authors.initials: M
authors.lastname: Albani
authors.forename: Letizia
authors.initials: L
authors.lastname: Lanini
authors.forename: Maria Linda
authors.initials: ML
authors.lastname: Vatteroni
authors.forename: Mario
authors.initials: M
authors.lastname: Petrini
authors.forename: Luca
authors.initials: L
authors.lastname: Ceccherini-Nelli
authors.forename: Mauro
authors.initials: M
authors.lastname: Pistello
authors.forename: Mauro
authors.initials: M
authors.lastname: Bendinelli
mesh_terms: D000328:Adult; D004267:DNA Viruses / Q000254:growth & development* / Q000302:isolation & purification; D004279:DNA, Viral / Q000097:blood*; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma / Q000821:virology*; D019562:Viral Load; D014766:Viremia
chemical_list: D004279:DNA, Viral
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