title: [Immunoenzyme technique for detection of salivary anti-diphtheria antibacterial antibodies].
abstract: Enzyme immunoassay for determining salivary anti-diphtheria antibacterial IgA was developed to evaluate local anti-diphtheria immunity. One hundred and thirty-one apparently healthy preschool and school children aged 2 to 16 years, inoculated with diphtheria and tetanus toxoids and pertussis and attenuated diphtheria and tetanus toxoid vaccines by the immunization schedules. The apparently healthy children's saliva were found to have anti-diphtheria antibacterial sIgA, the mean content of which in the examinees aged 2-16 years was 49.4 +/- 3.0 units/ml and depended on age. The level of antibacterial anti-diphtheria sIgA significantly increased in children by age 7-9 years and unchanged by 16 years of age. Comparison of sIgA levels in children with diphtheria morbidity could identify 2-6-year-old children as a diphtheria infection risk group.
authors.forename: A V
authors.initials: AV
authors.lastname: Labushkina
authors.forename: G G
authors.initials: GG
authors.lastname: Kharseeva
authors.forename: A R
authors.initials: AR
authors.lastname: Kvasov
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D004165:Diphtheria / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D018928:Immunity, Mucosal; D007124:Immunoenzyme Techniques; D007070:Immunoglobulin A / Q000032:analysis*; D012463:Saliva / Q000737:chemistry*
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A