title: Evolution and spermatogenesis.
abstract: Sexual reproduction depends on the production of haploid gametes, and their fusion to form diploid zygotes. Here, we discuss sperm production and function in a molecular and functional evolutionary context, drawing predominantly from studies in model organisms (mice, Drosophila, Caenorhabditis elegans). We consider the mechanisms involved in establishing and maintaining a germline stem cell population in testes, as well as the factors that regulate their contribution to the pool of differentiating cells. These processes involve considerable interaction between the germline and the soma, and we focus on regulatory signalling events in a variety of organisms. The male germline has a unique transcriptional profile, including expression of many testis-specific genes. The evolutionary pressures associated with gene duplication and acquisition of testis function are discussed in the context of genome organization and transcriptional regulation. Post-meiotic differentiation of spermatids involves very dramatic changes in cell shape and acquisition of highly specialized features. We discuss the variety of sperm motility mechanisms and how various reproductive strategies are associated with the diversity of sperm forms found in animals.
authors.affiliation: School of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AT, UK. white-cooperh@cf.ac.uk
authors.forename: Helen
authors.initials: H
authors.lastname: White-Cooper
authors.forename: Nina
authors.initials: N
authors.lastname: Bausek
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002454:Cell Differentiation / Q000235:genetics; D020440:Gene Duplication; D018507:Gene Expression Regulation, Developmental; D008297:Male; D051379:Mice; D013091:Spermatogenesis / Q000235:genetics*; D013737:Testis / Q000502:physiology*; D014158:Transcription, Genetic
references.citation: Science. 2007 Sep 21;317(5845):1722-6
references.pmid: 17823316
references.citation: Zoology (Jena). 2001;104(1):25-31
references.pmid: 16351815
references.citation: Ann N Y Acad Sci. 2002 Dec;981:7-49
references.pmid: 12547672
references.citation: J Cell Sci. 2005 Dec 1;118(Pt 23):5421-30
references.pmid: 16278296
references.citation: EMBO J. 1989 May;8(5):1559-65
references.pmid: 2504583
references.citation: Fertil Steril. 2006 Feb;85(2):391-4
references.pmid: 16595216
references.citation: Development. 2005 May;132(10):2345-53
references.pmid: 15829517
references.citation: J Cell Sci. 2005 Jan 15;118(Pt 2):269-82
references.pmid: 15654016
references.citation: Curr Biol. 2006 Mar 7;16(5):R160-2
references.pmid: 16527731
references.citation: Proc Biol Sci. 2003 Oct 7;270(1528):2079-86
references.pmid: 14561298
references.citation: Development. 2003 Dec;130(24):5869-84
references.pmid: 14597570
references.citation: Science. 2003 Mar 28;299(5615):2054-8
references.pmid: 12663925
references.citation: Nat Rev Genet. 2002 Feb;3(2):137-44
references.pmid: 11836507
references.citation: Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4148-52
references.pmid: 15024099
references.citation: Mech Dev. 2000 Mar 1;91(1-2):61-8
references.pmid: 10704831
references.citation: Dev Biol. 2001 Feb 15;230(2):101-9
references.pmid: 11161565
references.citation: Genetics. 2002 Sep;162(1):273-84
references.pmid: 12242239
references.citation: Cell Cycle. 2006 Feb;5(3):274-8
references.pmid: 16410732
references.citation: Experientia. 1995 Aug 16;51(8):817-23
references.pmid: 7649241
references.citation: Genesis. 2004 Jun;39(2):84-93
references.pmid: 15170693
references.citation: Cell Motil Cytoskeleton. 2009 May;66(5):248-59
references.pmid: 19306353
references.citation: Science. 2003 Jan 31;299(5607):697-700
references.pmid: 12511656
references.citation: Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):14869-74
references.pmid: 14657366
references.citation: Int J Hematol. 2005 Dec;82(5):381-8
references.pmid: 16533739
references.citation: Nat Genet. 2001 Apr;27(4):422-6
references.pmid: 11279525
references.citation: Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9935-9
references.pmid: 16777968
references.citation: Dev Biol. 1981 Jan 30;81(2):208-19
references.pmid: 7202837
references.citation: Mol Biol Cell. 2009 May;20(10):2605-14
references.pmid: 19321663
references.citation: Mol Biol Evol. 2003 Jan;20(1):18-20
references.pmid: 12519901
references.citation: Am J Anat. 1978 Sep;153(1):97-121
references.pmid: 707312
references.citation: Genome Res. 2009 Oct;19(10):1752-9
references.pmid: 19726446
references.citation: J Submicrosc Cytol Pathol. 1989 Oct;21(4):619-25
references.pmid: 2804950
references.citation: Genome Res. 2000 Dec;10(12):2030-43
references.pmid: 11116097
references.citation: Development. 2007 May;134(10):1823-31
references.pmid: 17329371
references.citation: Nature. 2005 Aug 18;436(7053):1030-4
references.pmid: 16107850
references.citation: Development. 2004 Jan;131(1):93-104
references.pmid: 14660440
references.citation: Cell. 1999 Jan 22;96(2):165-74
references.pmid: 9988212
references.citation: Naturwissenschaften. 2005 Jul;92(7):305-9
references.pmid: 15905978
references.citation: Dev Cell. 2002 Dec;3(6):765-78
references.pmid: 12479803
references.citation: Soc Reprod Fertil Suppl. 2007;64:13-38
references.pmid: 17491139
references.citation: Annu Rev Cell Dev Biol. 2005;21:605-31
references.pmid: 16212509
references.citation: PLoS Biol. 2007 Oct;5(10):e273
references.pmid: 17927450
references.citation: Nucleic Acids Res. 2005 Mar 08;33(5):1435-44
references.pmid: 15755746
references.citation: Mol Hum Reprod. 2008 Mar;14(3):137-42
references.pmid: 18256174
references.citation: Genetics. 2007 Nov;177(3):1321-35
references.pmid: 18039869
references.citation: J Pathol. 2009 Jan;217(2):186-98
references.pmid: 19065622
references.citation: Curr Biol. 2006 Feb 7;16(3):252-63
references.pmid: 16461278
references.citation: J Biol Chem. 1981 Feb 10;256(3):1447-52
references.pmid: 6256397
references.citation: Dev Biol. 1996 Aug 25;178(1):124-32
references.pmid: 8812114
references.citation: Biochim Biophys Acta. 2008 Nov;1783(11):2155-60
references.pmid: 18706455
references.citation: Recent Prog Horm Res. 2002;57:103-28
references.pmid: 12017539
references.citation: Annu Rev Cell Dev Biol. 2008;24:263-86
references.pmid: 18588486
references.citation: Cell Motil Cytoskeleton. 1994;28(2):135-42
references.pmid: 8087872
references.citation: Nature. 1953 Mar 14;171(4350):485-6
references.pmid: 13046534
references.citation: Annu Rev Cell Dev Biol. 2007;23:405-33
references.pmid: 17506698
references.citation: J Reprod Fertil. 1990 May;89(1):135-48
references.pmid: 2197409
references.citation: Nature. 1997 May 29;387(6632):489-93
references.pmid: 9168109
references.citation: Biol Rev Camb Philos Soc. 1992 Nov;67(4):551-93
references.pmid: 1463811
references.citation: Nature. 2002 Apr 4;416(6880):496
references.pmid: 11932733
references.citation: Trends Genet. 2005 Feb;21(2):93-102
references.pmid: 15661355
references.citation: Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3282-7
references.pmid: 19218438
references.citation: Nat Genet. 2004 Oct;36(10):1065-71
references.pmid: 15361872
references.citation: Nat Rev Mol Cell Biol. 2009 Feb;10(2):116-25
references.pmid: 19165214
references.citation: Mech Dev. 2009 May-Jun;126(5-6):366-81
references.pmid: 19249358
references.citation: J Cell Biol. 1970 Feb;44(2):243-77
references.pmid: 4903810
references.citation: Development. 2004 Mar;131(6):1365-75
references.pmid: 14973292
references.citation: Development. 2000 Feb;127(3):503-14
references.pmid: 10631171
references.citation: Science. 2001 Dec 21;294(5551):2542-5
references.pmid: 11752574
references.citation: J Cell Sci. 1999 Oct;112 ( Pt 20):3537-48
references.pmid: 10504302
references.citation: Dev Genes Evol. 2007 Apr;217(4):275-87
references.pmid: 17333259
references.citation: Chromosoma. 2003 May;111(8):473-82
references.pmid: 12743711
references.citation: Am Nat. 1997 May;149(5):933-54
references.pmid: 18811256
references.citation: J Mol Evol. 2004 Jun;58(6):673-80
references.pmid: 15461424
references.citation: Evol Dev. 2006 Jan-Feb;8(1):23-9
references.pmid: 16409380
references.citation: J Biol. 2002;1(1):5
references.pmid: 12144710
references.citation: Dev Biol. 1979 Dec;73(2):304-21
references.pmid: 499670
references.citation: C R Acad Hebd Seances Acad Sci D. 1977 Oct 3;285(7):785-8
references.pmid: 411582
references.citation: Mol Cell. 2007 Jun 8;26(5):603-9
references.pmid: 17560367
references.citation: Curr Biol. 2003 Apr 29;13(9):754-7
references.pmid: 12725733
references.citation: Semin Reprod Med. 2007 May;25(3):208-19
references.pmid: 17447210
references.citation: Nat Genet. 2006 Dec;38(12):1440-5
references.pmid: 17099714
references.citation: Biol Rev Camb Philos Soc. 2008 May;83(2):191-208
references.pmid: 18397179
references.citation: J Cell Sci. 2005 Feb 15;118(Pt 4):665-72
references.pmid: 15701923
references.citation: Science. 2009 Sep 11;325(5946):1394-8
references.pmid: 19745153
references.citation: Nature. 2009 Nov 5;462(7269):65-70
references.pmid: 19890324
references.citation: Rev Reprod. 2000 May;5(2):75-83
references.pmid: 10864851
references.citation: Biol Reprod. 2006 Feb;74(2):275-87
references.pmid: 16221991
references.citation: Int J Dev Biol. 2008;52(5-6):439-47
references.pmid: 18649256
references.citation: BMC Evol Biol. 2009 Sep 25;9:240
references.pmid: 19781084
references.citation: Development. 2006 Apr;133(8):1495-505
references.pmid: 16540512
references.citation: Dev Biol. 2009 Feb 15;326(2):295-304
references.pmid: 19100255
references.citation: Science. 2001 Dec 21;294(5551):2546-9
references.pmid: 11752575
references.citation: Genetics. 2007 Jun;176(2):1131-7
references.pmid: 17435230
references.citation: J Theor Biol. 2004 Jul 7;229(1):139-46
references.pmid: 15178192
references.citation: Nature. 2001 Oct 11;413(6856):603-9
references.pmid: 11595941
references.citation: Nat Genet. 2008 Jun;40(6):794-9
references.pmid: 18454149
references.citation: Cell. 2006 Jun 30;125(7):1375-86
references.pmid: 16814722
references.citation: Dev Biol. 2007 Mar 1;303(1):108-20
references.pmid: 17123504
references.citation: Science. 2004 May 28;304(5675):1331-4
references.pmid: 15143218
references.citation: Methods Enzymol. 2006;419:259-82
references.pmid: 17141059
references.citation: Genome Biol. 2004;5(6):R40
references.pmid: 15186491
references.citation: IUBMB Life. 2004 Jan;56(1):19-27
references.pmid: 14992376
references.citation: J Insect Physiol. 2001 Mar;47(3):245-255
references.pmid: 11119770
references.citation: Development. 2006 Jul;133(14):2605-16
references.pmid: 16794031
references.citation: Biol Rev Camb Philos Soc. 2004 Nov;79(4):795-814
references.pmid: 15682871
references.citation: Nat Genet. 2007 Jun;39(6):715-20
references.pmid: 17534367
references.citation: Nat Genet. 2001 May;28(1):10-2
references.pmid: 11326265
references.citation: Curr Biol. 2004 Jul 27;14(14):R578-89
references.pmid: 15268881
references.citation: Development. 1994 Oct;120(10):2913-24
references.pmid: 7607081
references.citation: Comp Biochem Physiol B. 1992 Aug;102(4):679-90
references.pmid: 1395503
references.citation: WormBook. 2006 Feb 01;:1-8
references.pmid: 18050481
references.citation: Mol Biol Evol. 2008 Oct;25(10):2157-66
references.pmid: 18653731
references.citation: Cytogenet Cell Genet. 1994;66(2):83-8
references.pmid: 8287688
references.citation: Nature. 2007 Nov 8;450(7167):238-41
references.pmid: 17994090
references.citation: Proc Natl Acad Sci U S A. 2006 May 30;103(22):8402-7
references.pmid: 16717192
references.citation: Dev Biol. 2006 Jun 1;294(1):92-103
references.pmid: 16566915
references.citation: Curr Biol. 2004 Jul 27;14(14):1284-90
references.pmid: 15268860
references.citation: Evolution. 2007 Apr;61(4):816-24
references.pmid: 17439614
references.citation: BMC Genomics. 2007 Jul 28;8:256
references.pmid: 17662146
references.citation: Proc Biol Sci. 2002 Nov 22;269(1507):2309-16
references.pmid: 12495497
references.citation: Ann N Y Acad Sci. 2007 Apr;1101:506-26
references.pmid: 17363437
references.citation: Curr Biol. 2006 Feb 7;16(3):287-95
references.pmid: 16461282
references.citation: Curr Biol. 2003 Dec 2;13(23):2065-72
references.pmid: 14653996
references.citation: Nature. 2002 Dec 12;420(6916):666-9
references.pmid: 12478293
references.citation: Proc Biol Sci. 1993 Sep 22;253(1338):255-62
references.pmid: 8234364
references.citation: Exp Cell Res. 1974 Mar 15;84(1):239-50
references.pmid: 4206336
references.citation: Dev Biol. 1989 Nov;136(1):154-66
references.pmid: 2806718
references.citation: Development. 1998 Dec;125(23):4749-55
references.pmid: 9806923
references.citation: J Ultrastruct Res. 1980 Dec;73(3):318-30
references.pmid: 7230323
references.citation: Nat Cell Biol. 2009 Feb;11(2):190-6
references.pmid: 19098901
references.citation: Genesis. 2008 Nov;46(11):605-13
references.pmid: 19003926
references.citation: Dev Biol. 2009 Oct 15;334(2):335-44
references.pmid: 19643104
references.citation: Genes Dev. 1998 Dec 1;12(23):3715-27
references.pmid: 9851978
references.citation: Hum Reprod Update. 2008 Nov-Dec;14(6):647-57
references.pmid: 18653675
references.citation: Cancer Res. 2006 May 1;66(9):4553-7
references.pmid: 16651403
references.citation: WormBook. 2005 Jul 28;:1-10
references.pmid: 18050414
references.citation: Genome Res. 2002 Dec;12(12):1854-9
references.pmid: 12466289
references.citation: Genetica. 2003 Jul;118(2-3):233-44
references.pmid: 12868612
references.citation: Trends Genet. 2003 May;19(5):243-7
references.pmid: 12711214
references.citation: Biol Reprod. 2007 Mar;76(3):353-61
references.pmid: 17123940
references.citation: Cell Mol Life Sci. 2008 Nov;65(21):3446-57
references.pmid: 18622578
references.citation: J Cell Sci. 2004 Nov 15;117(Pt 24):5835-45
references.pmid: 15522887
references.citation: Development. 2002 Aug;129(15):3533-44
references.pmid: 12117804
references.citation: Genetics. 1962 Dec;47:1719-36
references.pmid: 13929245