title: AP2/EREBP transcription factors are part of gene regulatory networks and integrate metabolic, hormonal and environmental signals in stress acclimation and retrograde signalling.
abstract: To optimize acclimation responses to environmental growth conditions, plants integrate and weigh a diversity of input signals. Signal integration within the signalling networks occurs at different sites including the level of transcription factor activation. Accumulating evidence assigns a major and diversified role in environmental signal integration to the family of APETALA 2/ethylene response element binding protein (AP2/EREBP) transcription factors. Presently, the Plant Transcription Factor Database 3.0 assigns 147 gene loci to this family in Arabidopsis thaliana, 200 in Populus trichocarpa and 163 in Oryza sativa subsp. japonica as compared to 13 to 14 in unicellular algae ( http://plntfdb.bio.uni-potsdam.de/v3.0/ ). AP2/EREBP transcription factors have been implicated in hormone, sugar and redox signalling in context of abiotic stresses such as cold and drought. This review exemplarily addresses present-day knowledge of selected AP2/EREBP with focus on a function in stress signal integration and retrograde signalling and defines AP2/EREBP-linked gene networks from transcriptional profiling-based graphical Gaussian models. The latter approach suggests highly interlinked functions of AP2/EREBPs in retrograde and stress signalling.
authors.affiliation: Biochemistry and Physiology of Plants-W5, Bielefeld University, 33501, Bielefeld, Germany. karl-josef.dietz@uni-bielefeld.de
authors.forename: Karl-Josef
authors.initials: KJ
authors.lastname: Dietz
authors.forename: Marc Oliver
authors.initials: MO
authors.lastname: Vogel
authors.forename: Andrea
authors.initials: A
authors.lastname: Viehhauser
mesh_terms: D029681:Arabidopsis Proteins / Q000145:classification / Q000235:genetics / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004777:Environment; D018506:Gene Expression Regulation, Plant; D053263:Gene Regulatory Networks; D017343:Genes, Plant; D010084:Oxidation-Reduction; D010802:Phylogeny; D010940:Plant Proteins / Q000235:genetics / Q000378:metabolism*; D010944:Plants / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013312:Stress, Physiological; D050656:Transcription Factor AP-2 / Q000235:genetics / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; D004268:DNA-Binding Proteins; D010940:Plant Proteins; D050656:Transcription Factor AP-2; C093680:ethylene-responsive element binding protein
references.citation: Int J Dev Biol. 2005;49(5-6):745-59
references.pmid: 16096979
references.citation: Physiol Plant. 2010 Apr;138(4):503-19
references.pmid: 20028479
references.citation: Biochem Biophys Res Commun. 2002 Jan 25;290(3):998-1009
references.pmid: 11798174
references.citation: J Biol Chem. 2004 Mar 19;279(12):11736-43
references.pmid: 14722088
references.citation: Physiol Plant. 2008 Jul;133(3):459-68
references.pmid: 18429942
references.citation: Plant J. 1998 Nov;16(4):433-42
references.pmid: 9881163
references.citation: Science. 2007 May 4;316(5825):715-9
references.pmid: 17395793
references.citation: Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):7076-81
references.pmid: 9192694
references.citation: Plant J. 2008 Apr;54(1):15-29
references.pmid: 18088305
references.citation: Stat Appl Genet Mol Biol. 2005;4:Article32
references.pmid: 16646851
references.citation: Plant Mol Biol. 2005 Dec;59(6):853-68
references.pmid: 16307362
references.citation: Plant Cell. 1994 Sep;6(9):1211-25
references.pmid: 7919989
references.citation: Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):1035-40
references.pmid: 9023378
references.citation: Plant Cell Physiol. 2008 Aug;49(8):1135-49
references.pmid: 18625610
references.citation: BMC Plant Biol. 2008 Apr 26;8:48
references.pmid: 18439303
references.citation: Plant Cell. 2002 Aug;14(8):1675-90
references.pmid: 12172015
references.citation: BMC Bioinformatics. 2007 Feb 07;8:42
references.pmid: 17286856
references.citation: Plant Cell. 2002 Nov;14(11):2723-43
references.pmid: 12417697
references.citation: Mol Genet Genomics. 2007 Jun;277(6):631-46
references.pmid: 17295027
references.citation: Trends Biotechnol. 2002 Nov;20(11):467-72
references.pmid: 12413821
references.citation: J Biol Chem. 2008 Mar 7;283(10):6261-71
references.pmid: 18089556
references.citation: Plant Cell. 2003 Jan;15(1):165-78
references.pmid: 12509529
references.citation: Plant Cell. 1998 Jun;10(6):1043-54
references.pmid: 9634591
references.citation: Plant Physiol. 2003 Jan;131(1):317-25
references.pmid: 12529539
references.citation: Mol Biol Evol. 1987 Jul;4(4):406-25
references.pmid: 3447015
references.citation: Plant Cell. 2000 Mar;12(3):393-404
references.pmid: 10715325
references.citation: Plant Cell. 2009 May;21(5):1360-72
references.pmid: 19482972
references.citation: Nucleic Acids Res. 2008 Jan;36(Database issue):D1009-14
references.pmid: 17986450
references.citation: Plant Physiol. 2009 Aug;150(4):1916-29
references.pmid: 19542297
references.citation: Nucleic Acids Res. 2006 Jul 1;34(Web Server issue):W504-9
references.pmid: 16845059
references.citation: Plant Cell Physiol. 2004 Aug;45(8):997-1006
references.pmid: 15356325
references.citation: Genome Res. 2007 Nov;17(11):1614-25
references.pmid: 17921353
references.citation: Plant Cell Environ. 2002 Feb;25(2):223-228
references.pmid: 11841665
references.citation: Planta. 2003 Jan;216(3):523-34
references.pmid: 12520345
references.citation: Plant Biol (Stuttg). 2006 Jul;8(4):407-18
references.pmid: 16906481
references.citation: Curr Opin Plant Biol. 2000 Jun;3(3):217-23
references.pmid: 10837265
references.citation: BMC Bioinformatics. 2009 May 08;10:136
references.pmid: 19426475
references.citation: Mol Plant. 2008 Jan;1(1):42-57
references.pmid: 20031913
references.citation: Plant Cell. 1995 Apr;7(4):388-9
references.pmid: 7773013
references.citation: Bioinformatics. 2002 Feb;18(2):287-97
references.pmid: 11847076
references.citation: Plant J. 2001 May;26(4):421-33
references.pmid: 11439129
references.citation: Plant Cell. 2004 Sep;16(9):2265-77
references.pmid: 15319480
references.citation: Nucleic Acids Res. 2009 Jan;37(Database issue):D169-74
references.pmid: 18836194
references.citation: Plant Cell. 1998 Aug;10(8):1391-406
references.pmid: 9707537
references.citation: Proc Natl Acad Sci U S A. 1997 May 27;94(11):5961-6
references.pmid: 9159183
references.citation: Plant Cell Environ. 2006 Mar;29(3):426-34
references.pmid: 17080596
references.citation: Mol Biol Evol. 2007 Aug;24(8):1596-9
references.pmid: 17488738
references.citation: Mol Plant. 2008 Mar;1(2):198-217
references.pmid: 19825533
references.citation: Cell. 1991 Jun 14;65(6):991-1002
references.pmid: 1675158
references.citation: J Exp Bot. 2006;57(6):1211-23
references.pmid: 16551690
references.citation: Plant Cell. 1995 Feb;7(2):173-82
references.pmid: 7756828
references.citation: Plant Cell. 2005 Aug;17(8):2384-96
references.pmid: 15994908
references.citation: Plant J. 2004 Oct;40(1):22-34
references.pmid: 15361138
references.citation: Curr Opin Plant Biol. 2004 Feb;7(1):40-9
references.pmid: 14732440
references.citation: EMBO Rep. 2003 May;4(5):491-8
references.pmid: 12776738
references.citation: J Exp Bot. 2003 Jan;54(382):495-501
references.pmid: 12508060
references.citation: Plant Physiol. 2007 Nov;145(3):1073-85
references.pmid: 17873090
references.citation: Nucleic Acids Res. 1999 Jan 15;27(2):470-8
references.pmid: 9862967
references.citation: Plant Physiol. 2008 Dec;148(4):2050-8
references.pmid: 18829981
references.citation: Biochem Biophys Res Commun. 2008 Jul 4;371(3):468-74
references.pmid: 18442469
references.citation: Mol Biosyst. 2008 Mar;4(3):199-204
references.pmid: 18437262
references.citation: Plant Cell. 1996 Apr;8(4):659-71
references.pmid: 8624440