title: Dengue vaccines: state of the art.
abstract: BACKGROUND
  Dengue is a significant public health problem transcending geographical boundaries to place nearly 50% of the global population at risk. A vaccine to prevent dengue is an unmet need that should be addressed urgently.
  
  
  METHODS
  A brief introduction to dengue and a detailed review of the classical and modern approaches being undertaken currently to develop dengue vaccines described in recent patent literature, highlighting the inherent hurdles and challenges.
  
  
  RESULTS
  An understanding of the approaches being deployed to develop multiple viral and non-viral vaccine candidates and an appreciation of the complexity of developing dengue vaccines.
  
  
  CONCLUSIONS
  Live viral vaccines, which have advanced to clinical trials, have revealed new challenges, emphasizing the need to pursue non-viral alternatives simultaneously.
authors.affiliation: International Centre for Genetic Engineering & Biotechnology, Recombinant Gene Products Group, PO Box 10504, Aruna Asaf Ali Marg, New Delhi-110067, India. swami@icgeb.res.in
authors.forename: Sathyamangalam
authors.initials: S
authors.lastname: Swaminathan
authors.forename: Gaurav
authors.initials: G
authors.lastname: Batra
authors.forename: Navin
authors.initials: N
authors.lastname: Khanna
mesh_terms: D000818:Animals; D003715:Dengue / Q000276:immunology / Q000517:prevention & control*; D053059:Dengue Vaccines / Q000276:immunology*; D003716:Dengue Virus / Q000187:drug effects* / Q000276:immunology; D015195:Drug Design; D006801:Humans; D010330:Patents as Topic; D011634:Public Health
chemical_list: D053059:Dengue Vaccines