Imaging selective vulnerability in the developing nervous system.
Why do cells in the central nervous system respond differently to different stressors and why is this response so age-dependent? In the immature brain, there are regions of selective vulnerability that are predictable and depend on the age when the insult occurs and the severity of the insult. This damage is both region and cell population specific. Vulnerable cell populations include the subplate neurons and oligodendrocyte precursors early in development and the neurons closer to the end of human gestation. Mechanisms of injury include excitotoxicity, oxidative stress and inflammation as well as accelerated apoptosis. Advanced imaging techniques have shown us particular patterns of injury according to age at insult. These changes seen in the newborn at the time of injury on magnetic resonance imaging correlate well with the neurodevelopmental outcome. New questions about how the injury evolves and how the newborn brain adapts and repairs itself have emerged as we now know that injury in the newborn brain can evolve over days and weeks, rather than hours. The ability to follow these processes has allowed us to investigate the role of repair in attenuating the injury. Neurogenesis and angiogenesis exist in response to ischemic injury and can be enhanced by processes that are known to protect the brain. The injury response in the developing brain is a complex process that evolves over time and is amenable to repair.
Ferriero
Donna M
DM
Departments of Neurology and Pediatrics, Newborn Brain Research Institute, University of California-San Francisco, 521 Parnassus Avenue, San Francisco, CA 94143-0663, USA. donna.ferriero@ucsf.edu
Miller
Steven P
SP
D001921:Brain / Q000098:blood supply / Q000254:growth & development; D001930:Brain Injuries / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000473:pathology*; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging / Q000379:methods
Pediatrics. 2009 Feb;123(2):503-11
19171615
Neuroimage. 2004 Jul;22(3):1134-40
15219585
Neuroscience. 2003;121(3):619-28
14568022
J Pediatr. 2005 Apr;146(4):453-60
15812446
Neurobiol Dis. 1995 Jun;2(3):145-55
9173998
Neurobiol Dis. 1996 Feb;3(1):64-71
9173913
Brain Pathol. 2008 Apr;18(2):153-63
18177464
Ann Neurol. 1998 Aug;44(2):161-6
9708537
Lancet Neurol. 2009 Jan;8(1):110-24
19081519
Pediatr Res. 2004 Oct;56(4):656-62
15295091
Lancet Neurol. 2009 Nov;8(11):1042-55
19800293
N Engl J Med. 2009 Oct 1;361(14):1349-58
19797281
J Pediatr. 2004 Nov;145(5):593-9
15520756
Neuropediatrics. 2000 Jun;31(3):128-36
10963099
AJNR Am J Neuroradiol. 2003 Sep;24(8):1661-9
13679289
Ann Neurol. 2000 Jan;47(1):54-63
10632101
Ann Neurol. 2009 Aug;66(2):155-64
19743455
Stroke. 2007 Feb;38(2 Suppl):736-41
17261728
AJNR Am J Neuroradiol. 1998 Jan;19(1):143-9
9432172
Trends Neurosci. 2009 Sep;32(9):496-505
19712981
AJNR Am J Neuroradiol. 2002 Oct;23(9):1445-56
12372731
N Engl J Med. 2005 Oct 13;353(15):1574-84
16221780
N Engl J Med. 2007 Nov 8;357(19):1928-38
17989385
Ann Neurol. 2006 Apr;59(4):640-51
16450369
Lancet. 2003 Mar 1;361(9359):736-42
12620738
Circulation. 2010 Jan 5;121(1):26-33
20026783
Arch Dis Child Fetal Neonatal Ed. 1994 Sep;71(2):F107-10
7979462
Neuroimage. 2004 Jul;22(3):1302-14
15219602
Pediatrics. 2005 Jul;116(1):1-7
15995023
Pediatr Res. 2006 May;59(5):680-3
16627881
Brain. 2008 Nov;131(Pt 11):2975-85
18697910
Pediatrics. 1990 Jun;85(6):984-90
2339047
N Engl J Med. 2006 Aug 17;355(7):685-94
16914704
J Neurosci. 2005 Jun 22;25(25):5988-97
15976088
Proc Natl Acad Sci U S A. 2003 May 27;100(11):6801-6
12743362
BMJ. 1998 Dec 5;317(7172):1554-8
9836653
Pediatr Cardiol. 2003 Sep-Oct;24(5):436-43
14627309
J Pediatr. 2005 Nov;147(5):609-16
16291350
Neurology. 2002 Sep 24;59(6):824-33
12297561
AJNR Am J Neuroradiol. 1999 Aug;20(7):1349-57
10472997
Lancet. 2005 Feb 19-25;365(9460):663-70
15721471
Pediatrics. 2003 Nov;112(5):e359
14595077
Dev Neurosci. 2007;29(4-5):321-30
17762200
J Neurosci. 2003 Apr 15;23(8):3308-15
12716938
Ann Neurol. 2008 Apr;63(4):520-30
18393269
J Comp Neurol. 1990 Jul 15;297(3):441-70
2398142
J Neuropathol Exp Neurol. 2003 May;62(5):441-50
12769184
Science. 2004 Jul 2;305(5680):99-103
15232110
Nat Med. 2005 Sep;11(9):966-72
16086023
Neuroimage. 2007 Feb 1;34(3):896-904
17174575
Magn Reson Med. 2002 Dec;48(6):949-58
12465103
Pediatr Neurol. 2004 Apr;30(4):227-35
15087099
Neuroimage. 2005 Sep;27(3):579-86
15921934
Cereb Cortex. 2002 May;12(5):536-44
11950771
Pediatr Neurol. 2008 Jan;38(1):10-5
18054686
JAMA. 2004 Nov 17;292(19):2357-65
15547163
Dev Med Child Neurol. 2009 Sep;51(9):697-704
19416315
Pediatr Res. 1995 Dec;38(6):912-8
8618793
Brain. 2008 Nov;131(Pt 11):2986-94
18799516
Pediatrics. 2006 May;117(5):1626-31
16651316
J Neurosci. 2002 Jan 15;22(2):455-63
11784790
Neurobiol Dis. 2010 Jan;37(1):195-207
19822212
Brain Res Brain Res Rev. 2005 Dec 15;50(2):244-57
16216332
Neurosci Lett. 2000 Mar 17;282(1-2):113-6
10713409
Ann Neurol. 1988 Nov;24(5):670-6
2904792
J Pediatr. 2008 Aug;153(2):170-5, 175.e1
18534228