Paternal levels of DNA damage in spermatozoa and maternal parity influence offspring mortality in an endangered ungulate.
Understanding which factors influence offspring mortality rates is a major challenge since it influences population dynamics and may constrain the chances of recovery among endangered species. Most studies have focused on the effects of maternal and environmental factors, but little is known about paternal factors. Among most polygynous mammals, males only contribute the haploid genome to their offspring, but the possibility that sperm DNA integrity may influence offspring survival has not been explored. We examined several maternal, paternal and individual factors that may influence offspring survival in an endangered species (Gazella cuvieri). Levels of sperm DNA damage had the largest impact upon offspring mortality rates, followed by maternal parity. In addition, there was a significant interaction between these two variables, so that offspring born to primiparous mothers were more likely to die if their father had high levels of sperm DNA damage, but this was not the case among multiparous mothers. Thus, multiparous mothers seem to protect their offspring from the deleterious effects of sperm DNA damage. Since levels of sperm DNA damage seem to be higher among endangered species, more attention should be paid to the impact of this largely ignored factor among the viability of endangered species.
Ruiz-López
María José
MJ
Reproductive Ecology and Biology Group, Museo Nacional de Ciencias Naturales (CSIC), José Gutierrez Abascal 2, 28006 Madrid, Spain.
Espeso
Gerardo
G
Evenson
Donald P
DP
Roldan
Eduardo R S
ER
Gomendio
Montserrat
M
D000818:Animals; D004249:DNA Damage; D053938:DNA Fragmentation; D056727:Endangered Species; D005260:Female; D008297:Male; D009026:Mortality; D010298:Parity; D011247:Pregnancy; D012098:Reproduction / Q000502:physiology*; D012307:Risk Factors; D012418:Ruminants / Q000235:genetics*; D013094:Spermatozoa
Mutat Res. 1996 Apr 13;351(2):199-203
8622715
J Androl. 2006 Mar-Apr;27(2):176-88
16304212
Cell Tissue Res. 2005 Oct;322(1):33-41
15912407
Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9601-6
16766665
Fertil Steril. 2008 Aug;90(2):352-9
17904130
Theriogenology. 1997 May;47(7):1433-43
16728089
Proc Biol Sci. 2000 May 7;267(1446):875-82
10853729
Proc Biol Sci. 1998 Feb 7;265(1392):243-8
9493409
Fertil Steril. 2003 Dec;80(6):1420-30
14667878
Nature. 2004 Nov 4;432(7013):48-52
15525979
Biol Reprod. 2001 Jun;64(6):1761-8
11369606
Science. 1979 Nov 30;206(4422):1101-3
493997
Reproduction. 2001 Oct;122(4):497-506
11570956
Evolution. 1999 Dec;53(6):1951-1960
28565463
Biol Reprod. 2005 Aug;73(2):289-96
15772260
J Natl Cancer Inst. 1997 Feb 5;89(3):238-44
9017004
Mol Ecol. 2009 Apr;18(7):1352-64
19368643
Biol Reprod. 2003 Aug;69(2):602-11
12700201
Biol Lett. 2009 Oct 23;5(5):663-6
19493877
J Reprod Fertil. 1989 Nov;87(2):529-42
2600908
Hum Reprod. 2006 Sep;21(9):2228-37
16790612
Int J Androl. 2009 Feb;32(1):46-56
19076252
Soc Reprod Fertil Suppl. 2007;65:93-113
17644957
J Reprod Fertil. 1978 Nov;54(2):325-34
569204
Hum Reprod. 2008 Dec;23(12):2663-8
18757447
Mol Cell Biol. 2002 Apr;22(7):2220-8
11884608
Hum Reprod. 2008 Jun;23(6):1297-305
18375939
Theriogenology. 2006 Mar 15;65(5):979-91
16242181
Anim Reprod Sci. 2006 May;92(3-4):373-83
16054784
PLoS Biol. 2008 Feb;6(2):e30
18271627
Proc Biol Sci. 1998 May 7;265(1398):803-9
9628038