title: Changes in electrical properties of command neurons during protective effect of low doses of antibodies to S100 protein on the development of long-term sensitization in Helix lucorum.
abstract: We studied the effect of antibodies to Ca(2+)-binding protein S100 in a dilution of 10(-12) (LAT-S100) on the development of long-term sensitization in Helix lucorum, a neurobiological model of anxious and depressive states. After administration of LAT-S100 preventing the development of long-term sensitization before training, the membrane and threshold potentials in command neurons regulating defense behavior decreased less markedly than during long-term sensitization. It is assumed that the "protective" effect is associated with mechanisms of long-term potential maintenance and changes in intra- and extracellular balance of Ca(2+)-binding protein S100.
authors.affiliation: E. K. Zavoiskii Physicotechnical Institute, Kazan' Research Center, Russian Academy of Sciences, Moscow, Russia.
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Timoshenko
authors.forename: V V
authors.initials: VV
authors.lastname: Andrianov
authors.forename: T Kh
authors.initials: TKh
authors.lastname: Gainutdinova
authors.forename: Kh L
authors.initials: KhL
authors.lastname: Gainutdinov
authors.forename: L N
authors.initials: LN
authors.lastname: Muranova
authors.forename: R R
authors.initials: RR
authors.lastname: Tagirova
authors.forename: M B
authors.initials: MB
authors.lastname: Shtark
authors.forename: O I
authors.initials: OI
authors.lastname: Epstein
mesh_terms: D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D004594:Electrophysiology; D006372:Helix, Snails / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D009418:S100 Proteins / Q000276:immunology*
chemical_list: D000906:Antibodies; D009418:S100 Proteins