title: Aggressive fibromatosis of the head and neck: a new classification based on a literature review over 40 years (1968-2008).
abstract: BACKGROUND
  Fibromatosis is an aggressive fibrous tumor of unknown etiology that is, in some cases, lethal. Until now, there has been no particular classification for the head and neck. Therefore, the aim of the present study was to review the current literature in order to propose a new classification for future studies.
  
  
  METHODS
  An evidence-based literature review was conducted from the last 40 years regarding aggressive fibromatosis in the head and neck. Studies that summarized patients' data without including individual data were excluded.
  
  
  RESULTS
  Between 1968 and 2008, 179 cases with aggressive fibromatosis of the head and neck were published. The male to female ratio was 91 to 82 with a mean age of 16.87 years, and 57.32% of the described cases that involved the head and neck were found in patients under 11 years. The most common localization was the mandible, followed by the neck. All together, 143 patients were followed up, and in 43 (30.07%), a recurrence was seen.
  
  
  CONCLUSIONS
  No clear prognostic factors for recurrence (age, sex, or localization) were observed. A new classification with regard to hormone receptors and bone involvement could improve the understanding of risk factors and thereby assist in future studies.
authors.affiliation: Department of Craniomaxillofacial and Oral Surgery, University of Zurich, Frauenklinikstr. 24, CH-8091 Zurich, Switzerland. astridkruse@gmx.ch
authors.forename: Astrid L
authors.initials: AL
authors.lastname: Kruse
authors.forename: Heinz T
authors.initials: HT
authors.lastname: Luebbers
authors.forename: Klaus W
authors.initials: KW
authors.lastname: Grätz
authors.forename: Joachim A
authors.initials: JA
authors.lastname: Obwegeser
mesh_terms: D000293:Adolescent; D000367:Age Factors; D002648:Child; D055094:Evidence-Based Dentistry; D005260:Female; D018222:Desmoid Tumors / Q000145:classification*; D006258:Head and Neck Neoplasms / Q000145:classification*; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000145:classification; D012737:Sex Factors
references.citation: Clin Oncol (R Coll Radiol). 2001;13(5):378-83
references.pmid: 11716234
references.citation: AJR Am J Roentgenol. 2002 Jan;178(1):191-9
references.pmid: 11756119
references.citation: Cancer. 1997 Jul 15;80(2):334-40
references.pmid: 9217047
references.citation: HNO. 1981 Apr;29(4):105-11
references.pmid: 7228744
references.citation: Int J Pediatr Otorhinolaryngol. 2005 Jun;69(6):847-52
references.pmid: 15885340
references.citation: Cancer Genet Cytogenet. 1996 Dec;92(2):147-9
references.pmid: 8976373
references.citation: J Clin Oncol. 2006 Mar 1;24(7):1195-203
references.pmid: 16505440
references.citation: Cancer. 2002 Dec 1;95(11):2373-9
references.pmid: 12436445
references.citation: J Clin Oncol. 2003 Apr 1;21(7):1390-7
references.pmid: 12663732
references.citation: Orthop Rev. 1987 Jul;16(7):481-8
references.pmid: 3331192
references.citation: Lancet. 1993 Oct 2;342(8875):848-50
references.pmid: 8104277
references.citation: Histopathology. 2007 Mar;50(4):491-7
references.pmid: 17448025
references.citation: Arch Surg. 1983 Nov;118(11):1318-22
references.pmid: 6639341
references.citation: Cancer. 2005 Sep 1;104(5):1090-9
references.pmid: 16015632
references.citation: J Clin Oncol. 1995 Nov;13(11):2813-8
references.pmid: 7595743
references.citation: J Postgrad Med. 1994 Oct-Dec;40(4):225-7
references.pmid: 9136247
references.citation: Cancer. 2001 Sep 1;92(5):1259-64
references.pmid: 11571741
references.citation: Cancer. 1962 Sep-Oct;15:1028-40
references.pmid: 13917557
references.citation: Arch Surg. 1989 Feb;124(2):191-6
references.pmid: 2916941
references.citation: Int J Radiat Oncol Biol Phys. 1998 Feb 1;40(3):637-45
references.pmid: 9486614
references.citation: Am J Clin Pathol. 1982 Jun;77(6):681-5
references.pmid: 7091048
references.citation: Am J Surg. 1966 Oct;112(4):615-22
references.pmid: 5915310
references.citation: Arch Pathol Lab Med. 2009 Sep;133(9):1370-4
references.pmid: 19722741
references.citation: J Pediatr Surg. 1993 Nov;28(11):1446-50
references.pmid: 8301457
references.citation: Mod Pathol. 2000 Oct;13(10):1080-5
references.pmid: 11048801
references.citation: Cancer. 1954 Sep;7(5):953-78
references.pmid: 13199773
references.citation: Am J Surg. 1966 Oct;112(4):609-14
references.pmid: 5915309
references.citation: Cancer. 1960 Jul-Aug;13:825-36
references.pmid: 14405434
references.citation: Int J Oral Maxillofac Surg. 2004 Sep;33(6):606-9
references.pmid: 15308262
references.citation: Am J Clin Pathol. 1982 Jun;77(6):665-73
references.pmid: 7091046
references.citation: J Hematol Oncol. 2008 May 28;1:3
references.pmid: 18577255
references.citation: Br J Oral Maxillofac Surg. 1998 Oct;36(5):384-8
references.pmid: 9831061
references.citation: J Surg Oncol. 2000 Jan;73(1):21-5
references.pmid: 10649274
references.citation: Oncology. 2003;64(4):346-52
references.pmid: 12759531
references.citation: Oral Surg Oral Med Oral Pathol. 1994 Apr;77(4):373-86
references.pmid: 8015802
references.citation: Br J Surg. 1995 Apr;82(4):510-4
references.pmid: 7613897
references.citation: Int J Pediatr Otorhinolaryngol. 2000 Jul 14;53(3):235-44
references.pmid: 10930641
references.citation: Am J Surg Pathol. 1977 Sep;1(3):255-70
references.pmid: 920873