Do weather-related ambient atmospheric-pressure changes influence sleep disordered breathing?
OBJECTIVE
High-altitude studies of sleep disordered breathing (SDB) show increases in apnea hypopnea indices with elevation gains. Hypoxic changes, rather than reductions in atmospheric pressure (AP), are thought to be the driving factor. Ambient pressure-related changes in SDB have not been extensively studied at low altitude. We performed a cross-sectional study of weather-related AP effects on measures of SDB at the University of WashingtonMedicine Sleep Institute, a Seattle, Washington-based polysomnography lab located 200 feet above sea level.


METHODS
Obstructive, central, and apnea-hypopnea indices from 537 patients were retrospectively correlated to mean 8-hour date-matched overnight AP data. Linear regression analysis and interquartile comparison of AP-related respiratory indices were performed and adjusted for age, sex, and body mass index.


RESULTS
The obstructive apnea index increased with lower weather-related APs (p = 0.01 for linear trend), interquartile analysis showed significant worsening with lowered mean, minimum, and maximum nightly APs. Similar changes were not seen with central or apnea-hypopnea indices.


CONCLUSIONS
The obstructive apnea index is altered by changes in weather-related AP during diagnostic polysomnography performed at 200 feet above sea level. Small changes in ambient atmospheric pressure due to weather systems may be important in the pathophysiology and diagnosis of obstructive sleep apnea.
Doherty
Michael John
MJ
Swedish Epilepsy Center, Seattle, WA 98122, USA. Michael.doherty@swedish.org
Youn
Clover E
CE
Haltiner
Alan Matthew
AM
Watson
Nathaniel Fletcher
NF
D001274:Atmospheric Pressure; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000379:methods / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012891:Sleep Apnea Syndromes / Q000503:physiopathology*; D020182:Sleep Apnea, Central / Q000503:physiopathology; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology; D014861:Washington; D014887:Weather
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