Effect size of reference memory deficits in the Morris water maze in Tg2576 mice.
The most widely used mouse model of Alzheimer's disease is the Tg2576 (APP(SWE)) model. While general agreement about their neuropathology prevails, disparate results concerning cognitive changes have been reported. To resolve this controversy, we combined Morris water maze data collected over >10 years to determine the extent of memory impairment. APP(SWE) mice exhibited an age-dependent decline in memory, but the effect size was small when compared to non-transgenic littermates. Larger effect sizes were achieved when comparing APP(SWE) and Tg5469 (APP(WT)) mice.
Reed
Miranda N
MN
N. Bud Grossman Center, University of Minnesota, Minneapolis, MN 55455, United States.
Liu
Peng
P
Kotilinek
Linda A
LA
Ashe
Karen H
KH
D000367:Age Factors; D000544:Alzheimer Disease / Q000150:complications / Q000235:genetics; D016564:Amyloid beta-Protein Precursor / Q000235:genetics / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D008569:Memory Disorders / Q000209:etiology* / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D012737:Sex Factors
D016564:Amyloid beta-Protein Precursor
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