title: Y-haplotypes and idiopathic male infertility in an Indian population.
abstract: Infertility being a multifactorial disorder, both genetic and environmental factors contribute to the etiology of infertile phenotype. Chromosomal anomalies and Y-microdeletion are the established genetic risk factors of male infertility. Y-haplotypes has been found as risk factor for male infertility in certain populations, though in certain others no association has been reported, suggesting a population-specific association of these variations with male infertility. In a case-control study, 165 azoo-/oligospermic patients and 200 controls were haplotyped for certain Y-haplogroups for a possible association with idiopathic male infertility in an Indian population. Analysed Y-haplogroups showed no association with infertile phenotype. Thus this genetic factor is not a risk for infertility in the studied Indian population but that does not rule out the possibility of any of them, to be a risk in other populations.
authors.affiliation: Department of Molecular and Human Genetics, Banaras Hindu University, Varanasi, India.
authors.forename: Kiran
authors.initials: K
authors.lastname: Singh
authors.forename: Rajiva
authors.initials: R
authors.lastname: Raman
references.citation: Fertil Steril. 2003 Nov;80(5):1190-4
references.pmid: 14607573
references.citation: Fertil Steril. 1998 Sep;70(3):397-411
references.pmid: 9757865
references.citation: J Hum Genet. 1999;44(5):289-92
references.pmid: 10496069
references.citation: Am J Hum Genet. 2000 Dec;67(6):1526-43
references.pmid: 11078479
references.citation: Genome Res. 1997 Oct;7(10):996-1005
references.pmid: 9331370
references.citation: Int J Androl. 2005 Apr;28(2):115-9
references.pmid: 15811073
references.citation: Am J Med Genet A. 2003 Jan 15;116A(2):152-8
references.pmid: 12494434
references.citation: J Med Genet. 1996 Jun;33(6):465-8
references.pmid: 8782045
references.citation: J Endocrinol Invest. 2003 Jul;26(7):620-2
references.pmid: 14594111
references.citation: Hum Mol Genet. 1994 Jan;3(1):115-23
references.pmid: 7909247
references.citation: Nat Cell Biol. 2002 Oct;4 Suppl:s41-9
references.pmid: 12479614
references.citation: Hum Mol Genet. 2001 Sep 1;10(18):1873-7
references.pmid: 11555623
references.citation: Ann Hum Genet. 1999 Jan;63(Pt 1):63-80
references.pmid: 10738521
references.citation: N Engl J Med. 2001 Apr 12;344(15):1172-3
references.pmid: 11302150
references.citation: Results Probl Cell Differ. 2000;28:211-32
references.pmid: 10626300
references.citation: Nature. 1995 Nov 23;378(6555):379-80
references.pmid: 7477372
references.citation: Nat Rev Genet. 2003 Aug;4(8):598-612
references.pmid: 12897772
references.citation: Eur J Hum Genet. 1999 Sep;7(6):733-6
references.pmid: 10482965