title: Simultaneous spectrophotometric determination of lansoprazole and domperidone in capsule dosage form.
abstract: Two simple, accurate and precise spectrophotometric methods have been developed for simultaneous determination of lansoprazole and domperidone in pharmaceutical dosage form. Method A involves formation of Q-absorbance equation at 256.0 nm (isoabsorptive point) and at 294.2 nm while method B is two wavelength method where 277.6 nm, 302.1 nm were selected as lambda(1) and lambda(2) for determination of lansoprazole and 231.3 nm, 292.0 nm were selected as lambda(1) and lambda(2) for determination of domperidone. Both the methods were validated statistically and recovery studies were carried out. The Beer's law limits for each drug individually and in mixture was within the concentration range of 5-50 mug/ml. Linearity of lansoprazole and domperidone were in the range of 24-36 mug/ml and 8-12 mug/ml, respectively. The proposed methods have been applied successfully to the analysis of the cited drugs either in pure form or in pharmaceutical formulations with good accuracy and precision. The method herein described can be employed for quality control and routine analysis of drugs in pharmaceutical formulations.
authors.affiliation: Department of Pharmaceutical Chemistry, Sinhgad Institute of Pharmacy, 45-1/2/3, Narhe, Pune - 411 041, India.
authors.forename: A P
authors.initials: AP
authors.lastname: Sherje
authors.forename: A V
authors.initials: AV
authors.lastname: Kasture
authors.forename: K N
authors.initials: KN
authors.lastname: Gujar
authors.forename: P G
authors.initials: PG
authors.lastname: Yeole
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2003 Jan 15;783(2):453-9
references.pmid: 12482488
references.citation: Eur J Drug Metab Pharmacokinet. 1998 Apr-Jun;23(2):329-32
references.pmid: 9725501
references.citation: J Chromatogr B Biomed Sci Appl. 1997 May 23;693(1):199-204
references.pmid: 9200535
references.citation: J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 25;816(1-2):309-14
references.pmid: 15664363
references.citation: J Chromatogr A. 2002 Mar 8;949(1-2):65-70
references.pmid: 11999758
references.citation: J Pharm Biomed Anal. 2002 Nov 7;30(4):1133-42
references.pmid: 12408904