title: Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET).
abstract: OBJECTIVE
  To assess the potential effects of short-term exposure to particulate air pollution during follicular phase on clinical, laboratory, and pregnancy outcomes of women undergoing IVF/ET.
  
  
  METHODS
  Retrospective cohort study of 400 first IVF/ET cycles of women exposed to ambient particulate matter during follicular phase. Particulate matter (PM) was categorized into quartiles (Q(1): < or =30.48 microg/m(3), Q(2): 30.49-42.00 microg/m(3), Q(3): 42.01-56.72 microg/m(3), and Q(4): >56.72 microg/m(3)).
  
  
  RESULTS
  Clinical, laboratory, or treatment variables were not affected by follicular phase PM exposure periods. Women exposed to Q(4) period during the follicular phase of conception cycles had a higher risk of miscarriage (odds ratio, 5.05; 95% confidence interval: 1.04-25.51) when compared to women exposed to Q(1-3) periods.
  
  
  CONCLUSIONS
  Our results show an association between brief exposure to high levels of ambient PM during the preconceptional period and early pregnancy loss, although no effect of this exposure on clinical, laboratory, and treatment outcomes was observed.
authors.affiliation: Department of Pathology, University of São Paulo, Brazil. paulo@ceerh.com.br
authors.forename: Paulo Marcelo
authors.initials: PM
authors.lastname: Perin
authors.forename: Mariangela
authors.initials: M
authors.lastname: Maluf
authors.forename: Carlos Eduardo
authors.initials: CE
authors.lastname: Czeresnia
authors.forename: Daniela Aparecida Nicolosi Foltran
authors.initials: DA
authors.lastname: Januário
authors.forename: Paulo Hilário Nascimento
authors.initials: PH
authors.lastname: Saldiva
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D015331:Cohort Studies; D004624:Embryo Transfer; D005260:Female; D005306:Fertilization; D005307:Fertilization in Vitro; D005498:Follicular Phase / Q000378:metabolism; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D018811:Maternal Exposure / Q000009:adverse effects*; D052638:Particulate Matter / Q000633:toxicity*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies
chemical_list: D052638:Particulate Matter
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