title: The effects of cannabis and alcohol on simulated arterial driving: Influences of driving experience and task demand.
abstract: This study compared the effects of three doses of cannabis and alcohol (placebo, low and high doses), both alone and in combination, on the driving performance of young, novice drivers and more experienced drivers. Alcohol was administered as ethanol (95%) mixed with orange juice in doses of approximately 0, 0.4 and 0.6g/kg. Cannabis was administered by inhalation of smoke from pre-rolled cannabis cigarettes (supplied by the National Institute of Drug Abuse, USA). Active cigarettes contained 19 mg delta-9-THC. Using a counterbalanced design, the simulated driving performance of 25 experienced and 22 inexperienced drivers was tested under the nine different drug conditions in an arterial driving environment during which workload was varied through the drive characteristics as well as through the inclusion of a secondary task. High levels of cannabis generally induced greater impairment than lower levels, while alcohol at the doses used had few effects and did not produce synergistic effects when combined with cannabis. Both cannabis and alcohol were associated with increases in speed and lateral position variability, high dose cannabis was associated with decreased mean speed, increased mean and variability in headways, and longer reaction time, while in contrast alcohol was associated with a slight increase in mean speed. Given the limitations of the study, it is of great interest to further explore the qualitative impairments in driving performance associated with cannabis and alcohol separately and how these impairments may manifest in terms of crash characteristics.
authors.affiliation: Monash University Accident Research Centre, Monash University, Victoria 3800, Australia. Michael.Lenne@muarc.monash.edu.au
authors.forename: Michael G
authors.initials: MG
authors.lastname: Lenné
authors.forename: Paul M
authors.initials: PM
authors.lastname: Dietze
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Triggs
authors.forename: Susan
authors.initials: S
authors.lastname: Walmsley
authors.forename: Brendan
authors.initials: B
authors.lastname: Murphy
authors.forename: Jennifer R
authors.initials: JR
authors.lastname: Redman
mesh_terms: D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking / Q000009:adverse effects*; D001334:Automobile Driving; D002188:Cannabis / Q000009:adverse effects*; D016001:Confidence Intervals; D004311:Double-Blind Method; D013759:Dronabinol / Q000009:adverse effects*; D005260:Female; D006213:Hallucinogens / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000187:drug effects; D013647:Task Performance and Analysis; D055815:Young Adult
chemical_list: D006213:Hallucinogens; D013759:Dronabinol