Enhancement of organ regeneration in animal models by a stem cell-stimulating plant mixture.
Adult stem cells play an important role in the regeneration of damaged organs. Attempts have already been made to enhance stem cell production by cytokines, in order to increase the improvement of cardiac functions after myocardial infarction. In our present study we investigated the possibility whether instead of cytokine injection dietary stimulation of stem cell production accelerates the organ regeneration in animals. A dietary supplement, Olimpiq StemXCell (Crystal Institute Ltd., Eger, Hungary), containing plant extracts (previously proved to increase the number of circulating CD34(+) cells) was consumed in human equivalent doses by the experimental animals. In the first experiment carbon tetrachloride was applied to CBA/Ca mice, to induce liver damage, and liver weights between StemXCell-fed and control animals were compared 10 days after the treatment. In the second model experimental diabetes was induced in F344 rats by alloxan. Blood sugar levels were measured for 5 weeks in the control and StemXCell-fed groups. The third part of the study investigated the effect of StemXCell on cardiac functions. Eight weeks after causing a myocardial infarction in Wistar rats by isoproterenol, left ventricular ejection fraction was determined as a functional parameter of myocardial regeneration. In all three animal models StemXCell consumption statistically significantly improved the organ regeneration (relative liver weights, 4.78 +/-0.06 g/100 g vs. 4.97 +/- 0.07 g/100 g; blood sugar levels at week 5, 16 +/- 1.30 mmol/L vs. 10.2 +/- 0.92 mmol/L; ejection fraction, 57.5 +/- 2.23 vs. 68.2 +/- 4.94; controls vs. treated animals, respectively). Our study confirms the hypothesis that dietary enhancement of stem cell production may protect against organ injuries and helps in the regeneration.
Kiss
István
I
Institute of Preventive Medicine, Pécs University of Sciences, Hungary. istvan.kiss@aok.pte.hu
Tibold
Antal
A
Halmosi
Róbert
R
Bartha
Eva
E
Koltai
Katalin
K
Orsós
Zsuzsanna
Z
Bujdosó
László
L
Ember
István
I
D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000503:physiopathology; D019587:Dietary Supplements / Q000032:analysis*; D004195:Disease Models, Animal; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D008099:Liver / Q000503:physiopathology*; D008107:Liver Diseases / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009203:Myocardial Infarction / Q000188:drug therapy / Q000503:physiopathology; D010179:Pancreas / Q000503:physiopathology*; D010936:Plant Extracts / Q000008:administration & dosage*; D051381:Rats; D011916:Rats, Inbred F344; D017208:Rats, Wistar; D012038:Regeneration / Q000187:drug effects*; D013234:Stem Cells / Q000187:drug effects* / Q000502:physiology
D010936:Plant Extracts