title: Expression of STAMP2 in monocytes associates with cardiovascular alterations.
abstract: BACKGROUND
  Metabolic and inflammatory pathways crosstalk at many levels. In this study, we aimed to investigate the expression of six-transmembrane protein of prostate 2 (STAMP2) in macrophages and tried to search for the association between the decreased STAMP2 expression, if any, and carotid atherosclerosis as well as cardiac adaptations.
  
  
  METHODS
  A total of 97 unrelated Chinese subjects were recruited including 48 subjects with metabolic syndrome (MetS) and 49 controls. Clinical and biochemical characteristics were collected from subjects, with quantification of STAMP2 in monocyte/macrophages. All subjects underwent ultrasonography.
  
  
  RESULTS
  STAMP2 expression in macrophages was significantly decreased in MetS as compared with the control group (10.25 +/- 9.20 vs. 15.20 +/- 9.18, P = 0.009), especially in women patients. Partial correlation analysis showed that STAMP2 expression in macrophages correlated with BMI (r = -0.375, P = 0.045), age (r = 0.414, P = 0.026) and HDL (r = 0.377, P = 0.044) after controlling for systolic blood pressure (SBP). Furthermore, STAMP2 expression was correlated with PI (r = -0.454, P = 0.013), LVEF (r = -0.503, P = 0.005), LA-ESR (r = -0.424, P = 0.022), LA-S (r = 0.469, P = 0.010) and mitral E/A ratio (r = 0.492, P = 0.005) after controlling for SBP. Still, in multivariable analysis, STAMP2 expression was independently associated with IMT(mean), PI and mitral E/A ratio.
  
  
  CONCLUSIONS
  In MetS patients, especially women patients, STAMP2 expression was down-regulated in peripheral blood mononuclear cell, which was correlated with carotid atherosclerosis and cardiac adaptation.
authors.affiliation: Qilu Hospital of Shandong University, Ji'nan, China.
authors.forename: Zhi-Hao
authors.initials: ZH
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Hui-Ping
authors.initials: HP
authors.lastname: Gong
authors.forename: Zhong-Xiu
authors.initials: ZX
authors.lastname: Guo
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Shang
authors.forename: Jin-Bo
authors.initials: JB
authors.lastname: Feng
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Zhong
mesh_terms: D000367:Age Factors; D044466:Asian People; D050197:Atherosclerosis / Q000378:metabolism; D015992:Body Mass Index; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology*; D002340:Carotid Artery Diseases / Q000378:metabolism*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000032:analysis; D008264:Macrophages / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000378:metabolism*; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D015999:Multivariate Analysis; D010088:Oxidoreductases / Q000378:metabolism*; D012307:Risk Factors; D012737:Sex Factors; D014463:Ultrasonography; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D008075:Lipoproteins, HDL; D008565:Membrane Proteins; D010088:Oxidoreductases; C503310:STEAP4 protein, human