title: Evaluation of C-reactive protein and interleukin-6 in the peripheral blood of patients with chronic periodontitis.
abstract: OBJECTIVE
  The aim of the present study was to investigate systemic levels of inflammatory markers of cardiovascular diseases like C-reactive protein and interleukin-6 in patients with chronic periodontitis, in comparison to periodontally healthy individuals.
  
  
  METHODS
  A total of 42 individuals, both males and females above the age of 30 years, were included in the study. Healthy controls (Group I, n = 14), chronic localized periodontitis (Group II, n = 14), and chronic generalized periodontitis (Group III, n = 14), all without any medical disorder, were recruited. Peripheral blood samples were taken and C-reactive protein (CRP) levels were estimated in the serum samples by using the Particle-Enhanced Turbidimetric Immunoassay (PETIA) technique. Serum samples of Interleukin-6 (IL-6) were assayed by using the Chemiluminescent Immunoassay (IMMULITE) technique.
  
  
  RESULTS
  When mean CRP levels were compared between the groups, group III showed statistical significance when compared to group I (P = 0.04). Group III had a higher median IL-6 level (6.35 pg/mL) than Group II (< 5.0 pg/mL) and group I (< 5.0 pg/mL). Differences in median values of IL-6 were not statistically significant in any group (P = 0.29).
  
  
  CONCLUSIONS
  Periodontitis results in higher systemic levels of CRP and IL-6. These elevated inflammatory factors may increase inflammatory activity in atherosclerotic lesions and potentially increasing the risk for cardiovascular events.
authors.affiliation: Sr. Lecturer, Department of Periodontics, Meenakshi Ammal Dental College, Chennai, India.
authors.forename: Dhruva Kumar
authors.initials: DK
authors.lastname: Gani
authors.forename: Deepa
authors.initials: D
authors.lastname: Lakshmi
authors.forename: Rama
authors.initials: R
authors.lastname: Krishnan
authors.forename: Pamela
authors.initials: P
authors.lastname: Emmadi
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