Changes in electrical properties of command neurons during protective effect of low doses of antibodies to S100 protein on the development of long-term sensitization in Helix lucorum.
We studied the effect of antibodies to Ca(2+)-binding protein S100 in a dilution of 10(-12) (LAT-S100) on the development of long-term sensitization in Helix lucorum, a neurobiological model of anxious and depressive states. After administration of LAT-S100 preventing the development of long-term sensitization before training, the membrane and threshold potentials in command neurons regulating defense behavior decreased less markedly than during long-term sensitization. It is assumed that the "protective" effect is associated with mechanisms of long-term potential maintenance and changes in intra- and extracellular balance of Ca(2+)-binding protein S100.
Timoshenko
A Kh
AKh
E. K. Zavoiskii Physicotechnical Institute, Kazan' Research Center, Russian Academy of Sciences, Moscow, Russia.
Andrianov
V V
VV
Gainutdinova
T Kh
TKh
Gainutdinov
Kh L
KhL
Muranova
L N
LN
Tagirova
R R
RR
Shtark
M B
MB
Epstein
O I
OI
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D004594:Electrophysiology; D006372:Helix, Snails / Q000166:cytology / Q000187:drug effects / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D009418:S100 Proteins / Q000276:immunology*
D000906:Antibodies; D009418:S100 Proteins