The association of magnetic resonance imaging measures with cognitive function in a biracial population sample.
BACKGROUND
White matter hyperintensity volume (WMHV), cerebral infarcts, and total brain volume (TBV) are associated with cognitive function, but few studies have examined these associations in the general population or whether they differ by race.


OBJECTIVE
To examine the association of WMHV, cerebral infarcts, and TBV with global cognition and cognition in 5 separate domains in a biracial population sample.


METHODS
A biracial community population of Chicago, Illinois.


METHODS
Cross-sectional population study.


METHODS
The study population comprised 575 participants from the Chicago Health and Aging Project (CHAP).


METHODS
Volumetric magnetic resonance imaging (MRI) measures of WMHV, TBV, and cerebral infarcts and detailed neuropsychological testing assessments of global cognition and 5 cognitive domains.


RESULTS
Overall and among those without dementia, cognition was inversely associated with WMHV and number of infarcts but was positively associated with TBV. When all 3 measures were simultaneously added to the model, the association of global cognition with WMHV and TBV remained significant and unchanged but was no longer significant with infarcts. Among subjects without dementia, all 3 MRI measures were associated with performance in multiple cognitive domains, specifically perceptual speed. However, among subjects with dementia, only TBV was associated with cognition and performance in multiple cognitive systems. Race did not significantly modify any of these associations.


CONCLUSIONS
In this biracial general population sample, the associations of MRI measures with cognition differed according to clinical status of subjects (stronger among subjects without dementia) and were not modified by race. These associations did not affect all cognitive domains equally but were more consistent with impairments in perceptual speed.
Aggarwal
Neelum T
NT
Rush Alzheimer's Disease Center, 600 S Paulina Ave, Ste 1038, Chicago, IL 60612, USA. naggarw@rush.edu
Wilson
Robert S
RS
Bienias
Julia L
JL
De Jager
Philip L
PL
Bennett
David A
DA
Evans
Denis A
DA
DeCarli
Charles
C
D000368:Aged; D000369:Aged, 80 and over; D044383:Black People; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D020520:Brain Infarction / Q000453:epidemiology / Q000208:ethnology* / Q000473:pathology*; D001931:Brain Mapping; D002561:Cerebrovascular Disorders / Q000453:epidemiology / Q000208:ethnology / Q000473:pathology; D003071:Cognition / Q000502:physiology; D003072:Cognition Disorders / Q000453:epidemiology / Q000208:ethnology* / Q000473:pathology*; D015331:Cohort Studies; D015897:Comorbidity; D003430:Cross-Sectional Studies; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009483:Neuropsychological Tests; D011594:Psychometrics; D044469:Racial Groups; D012307:Risk Factors; D044465:White People
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