title: Multiple vaccinations and the risk of medically attended fever.
abstract: Recent increases in the number of vaccinations recommended for infants have triggered concerns about the safety of multiple vaccinations. This study evaluated rates of medically attended fever after infant vaccination using computerized data from 1991 to 2000 from two large U.S. provider groups. The rate of medically attended fever within 7 days after vaccination was low (6.4 per 1000 vaccination visits) and did not increase during the decade. Higher rates of fever occurred during periods when a third dose of oral polio vaccine was used (1994-1995) and when a now-discontinued oral rotavirus vaccine was used (1998-1999). These findings offer reassurance that the multiple vaccinations introduced during the decade studied were not associated with increases in medically attended fever.
authors.affiliation: Department of Population Medicine, Harvard Pilgrim Health Care Institute and Harvard Medical School, Boston, MA 02215, United States.
authors.forename: Nancy D
authors.initials: ND
authors.lastname: Lin
authors.forename: Ken
authors.initials: K
authors.lastname: Kleinman
authors.forename: K Arnold
authors.initials: KA
authors.lastname: Chan
authors.forename: Stephen
authors.initials: S
authors.lastname: Soumerai
authors.forename: Jyotsna
authors.initials: J
authors.lastname: Mehta
authors.forename: John P
authors.initials: JP
authors.lastname: Mullooly
authors.forename: David K
authors.initials: DK
authors.lastname: Shay
authors.forename: Margarette
authors.initials: M
authors.lastname: Kolczak
authors.forename: Tracy A
authors.initials: TA
authors.lastname: Lieu
mesh_terms: D005334:Fever / Q000209:etiology*; D006291:Health Policy; D006801:Humans; D007114:Immunization / Q000639:trends; D007115:Immunization Schedule; D007223:Infant; D012307:Risk Factors; D014611:Vaccination / Q000009:adverse effects*