title: Antidepressant-like profile and MAO-A inhibitory activity of 4-propyl-2H-benzo[h]-chromen-2-one.
abstract: OBJECTIVE
  To evaluate the central nervous pharmacological profile of 4-propyl-2H-benzo[h]-chromen-2-one (FCS-304) in ICR mice and its monoamine oxidase inhibitor activity.
  
  
  METHODS
  FCS-304 was evaluated in screening test of central nervous system in ICR mice and against MAO activity.
  
  
  RESULTS
  FCS-304 (25-200mg/Kg, p.o.) significantly reduced immobility time during the forced swimming test (FST) and tail suspension test (TST), but did not show effects in the rota-rod tests, maximal electroshock seizures (MES), pentylenetetrazole seizures, light-dark box, barbiturate sleeping time and cold plate tests. Furthermore, FCS-304 inhibited monoamine oxidase A (MAO-A) with IC50: 2.28+/-0.15microM, but not MAO-B.
  
  
  CONCLUSIONS
  These results suggest that FCS-304 could elicit antidepressant effects related to MAO-A inhibitory activity.
authors.affiliation: Pharmacy Department, School of Sciences, National University of Colombia, Colombia.
authors.forename: Nadezdha E
authors.initials: NE
authors.lastname: Vergel
authors.forename: José L
authors.initials: JL
authors.lastname: López
authors.forename: Francisco
authors.initials: F
authors.lastname: Orallo
authors.forename: Dolores
authors.initials: D
authors.lastname: Viña
authors.forename: Diana M
authors.initials: DM
authors.lastname: Buitrago
authors.forename: Esther
authors.initials: E
authors.lastname: del Olmo
authors.forename: Juan A
authors.initials: JA
authors.lastname: Mico
authors.forename: Mario F
authors.initials: MF
authors.lastname: Guerrero
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D002867:Chromones / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D012640:Seizures / Q000188:drug therapy; D012890:Sleep / Q000187:drug effects
chemical_list: C549557:4-propyl-2H-benzo(h)chromen-2-one; D000928:Antidepressive Agents; D002867:Chromones; D008996:Monoamine Oxidase Inhibitors