Liver and brain imaging through dimercaptosuccinic acid-coated iron oxide nanoparticles.
OBJECTIVE
Uptake, cytotoxicity and interaction of improved superparamagnetic iron oxide nanoparticles were studied in cells, tissues and organs after single and multiple exposures.


METHODS
We prepared dimercaptosuccinic acid-coated iron oxide nanoparticles by thermal decomposition in organic medium, resulting in aqueous suspensions with a small hydrodynamic size (< 100 nm), high saturation magnetization and susceptibility, high nuclear magnetic resonance contrast and low cytotoxicity.


RESULTS
In vitro and in vivo behavior showed that these nanoparticles are efficient carriers for drug delivery to the liver and brain that can be combined with MRI detection.
Mejías
Raquel
R
Centro Nacional de Biotecnología/CSIC, Spain.
Pérez-Yagüe
Sonia
S
Roca
Alejandro G
AG
Pérez
Nicolás
N
Villanueva
Angeles
A
Cañete
Magdalena
M
Mañes
Santos
S
Ruiz-Cabello
Jesús
J
Benito
Marina
M
Labarta
Amilcar
A
Batlle
Xavier
X
Veintemillas-Verdaguer
Sabino
S
Morales
M Puerto
MP
Barber
Domingo F
DF
Serna
Carlos J
CJ
D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D002470:Cell Survival; D005290:Ferric Compounds / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008099:Liver / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D051381:Rats; D004113:Succimer / Q000737:chemistry*
D005290:Ferric Compounds; C000499:ferric oxide; D004113:Succimer