Autophagy and innate immunity: triggering, targeting and tuning.
Autophagy is a conserved catabolic stress response pathway that is increasingly recognized as an important component of both innate and acquired immunity to pathogens. The activation of autophagy during infection not only provides cell-autonomous protection through lysosomal degradation of invading pathogens (xenophagy), but also regulates signaling by other innate immune pathways. This review will focus on recent advances in our understanding of three major areas of the interrelationship between autophagy and innate immunity, including how autophagy is triggered during infection, how invading pathogens are targeted to autophagosomes, and how the autophagy pathway participates in "tuning" the innate immune response.
Sumpter
Rhea
R
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Levine
Beth
B
D000818:Animals; D001343:Autophagy; D006801:Humans; D007113:Immunity, Innate; D007239:Infections / Q000276:immunology*; D015398:Signal Transduction
Science. 2006 Sep 8;313(5792):1438-41
16888103
PLoS Pathog. 2007 Aug 10;3(8):e111
17696608
Nat Immunol. 2008 Aug;9(8):908-16
18604211
Nature. 2008 Nov 13;456(7219):264-8
18849965
J Virol. 1993 Jun;67(6):3208-16
7684462
Proc Natl Acad Sci U S A. 2009 May 26;106(21):8653-8
19433799
Annu Rev Genet. 2009;43:67-93
19653858
J Biol Chem. 2009 Nov 20;284(47):32602-9
19783656
Cell Host Microbe. 2009 Jun 18;5(6):527-49
19527881
Annu Rev Biochem. 1998;67:227-64
9759489
Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14564-9
19667176
Cytokine. 2008 Sep;43(3):368-73
18715799
Mol Cell. 2009 Feb 27;33(4):505-16
19250911
Cell Death Differ. 2009 Jul;16(7):976-83
19444282
BMC Immunol. 2008 Jul 15;9:35
18627610
J Biol Chem. 2004 Jan 16;279(3):1892-8
14570915
J Virol. 1998 Nov;72(11):8586-96
9765397
Science. 2003 Oct 24;302(5645):654-9
14576437
Immunity. 2008 Oct 17;29(4):538-50
18818105
J Cell Biol. 2005 May 9;169(3):425-34
15866887
Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14050-5
17709747
Cell Death Differ. 2006 Mar;13(3):393-403
16397582
Cell Res. 2006 Nov;16(11):895-901
17088896
Mol Cell. 2008 Jun 20;30(6):678-88
18570871
Microbes Infect. 2007 Nov-Dec;9(14-15):1644-51
18023232
Science. 2000 Jan 28;287(5453):664-6
10650002
Immunol Rev. 2009 Jul;230(1):172-87
19594636
Autophagy. 2009 Jul;5(5):720-2
19395874
Cell. 2008 Jan 11;132(1):27-42
18191218
Clin Microbiol Rev. 2001 Oct;14(4):778-809, table of contents
11585785
Science. 2010 Jan 15;327(5963):291-5
20075244
J Immunol. 2009 Nov 1;183(9):5909-16
19812211
Annu Rev Immunol. 2005;23:275-306
15771572
Annu Rev Immunol. 2009;27:229-65
19302040
Autophagy. 2009 Apr;5(3):370-9
19164948
Neuron. 2002 Aug 29;35(5):921-33
12372286
Genetics. 1993 Apr;133(4):943-54
8462852
Cell. 2007 Dec 14;131(6):1149-63
18083104
Microbiol Mol Biol Rev. 2006 Dec;70(4):1032-60
17158706
Proc Natl Acad Sci U S A. 2009 Dec 8;106(49):20842-6
19926846
Science. 2007 Mar 9;315(5817):1398-401
17272685
Autophagy. 2008 Nov;4(8):998-1008
18818518
Nat Rev Mol Cell Biol. 2005 Jun;6(6):439-48
15928708
Science. 2002 Apr 12;296(5566):301-5
11951032
Nature. 2006 Jun 15;441(7095):880-4
16625205
J Biol Chem. 2006 Apr 21;281(16):11374-83
16495224
Immunity. 2009 Apr 17;30(4):588-98
19362021
Cell. 2009 Feb 20;136(4):731-45
19239892
Nature. 2007 Dec 20;450(7173):1253-7
18097414
J Clin Invest. 2010 Jan;120(1):127-41
20038797
Nature. 2006 Jun 15;441(7095):885-9
16625204
Cell. 2004 Dec 17;119(6):753-66
15607973
Cold Spring Harb Symp Quant Biol. 1989;54 Pt 1:1-13
2700931
Autophagy. 2006 Jan-Mar;2(1):24-9
16874088
Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1829-34
17267617
J Clin Invest. 2006 Aug;116(8):2161-72
16886061
Nat Rev Genet. 2007 May;8(5):395-403
17429433
Cell Microbiol. 2008 Nov;10(11):2197-207
18665841
PLoS One. 2008;3(10):e3391
18852889
Cell. 2005 Sep 23;122(6):927-39
16179260
Cell Host Microbe. 2008 Nov 13;4(5):458-69
18996346
J Biol Chem. 2007 Aug 17;282(33):24131-45
17580304
Annu Rev Immunol. 2009;27:423-49
19105657
Cell. 2006 Feb 24;124(4):783-801
16497588
Cell Host Microbe. 2007 Mar 15;1(1):23-35
18005679
WormBook. 2009 Aug 24;:1-26
19705512
Nature. 2009 Oct 8;461(7265):788-92
19776740
J Biol Chem. 2008 Nov 28;283(48):33175-82
18772134
Biochim Biophys Acta. 2009 Sep;1793(9):1452-60
19264097
Mol Cell. 2007 Jan 26;25(2):193-205
17244528
EMBO J. 2008 Apr 9;27(7):1110-21
18337753
Annu Rev Physiol. 1966;28:435-92
5322983
Nature. 1976 Dec 2;264(5585):477-80
1004583
Proc Natl Acad Sci U S A. 1997 Feb 4;94(3):843-8
9023344
Nat Immunol. 2009 Oct;10(10):1073-80
19701189
Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):190-5
11756670
Cell Death Differ. 2007 Sep;14(9):1576-82
17612585
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2770-5
19196953
EMBO J. 2007 Apr 4;26(7):1749-60
17347651
Cell Microbiol. 2010 Apr 1;12(4):530-44
19951367
Nat Genet. 2008 Sep;40(9):1107-12
19165925
Immunity. 2007 Jul;27(1):135-44
17658277
Immunity. 2006 Sep;25(3):373-81
16979569
Science. 2010 Jan 15;327(5963):296-300
20075245
Int Immunol. 2010 Mar;22(3):143-8
20089584
EMBO Rep. 2009 Mar;10(3):285-92
19180116
Science. 1990 Nov 30;250(4985):1262-6
2173860
Cell Host Microbe. 2009 Oct 22;6(4):354-66
19837375
Nat Cell Biol. 2009 Oct;11(10):1233-40
19749745
Biochem Biophys Res Commun. 2009 Feb 6;379(2):293-7
19103170
EMBO J. 2010 Feb 3;29(3):619-31
19959994
Cell Death Differ. 2007 Feb;14(2):230-9
16794605
Nat Immunol. 2009 Nov;10(11):1215-21
19820708
Mol Gen Genet. 1978 Feb 27;159(3):269-83
416336
Nat Immunol. 2010 Jan;11(1):55-62
19898471
Immunol Rev. 2007 Dec;220:214-24
17979849
Nat Immunol. 2009 Oct;10(10):1065-72
19609254
Science. 2004 Nov 5;306(5698):1037-40
15528445
Nat Med. 2010 Jan;16(1):90-7
19966812
Cell Res. 2007 Jun;17(6):520-30
17563756
Cell. 2007 Apr 6;129(1):45-56
17418785
Sci STKE. 2006 Oct 17;2006(357):re13
17047224
Nature. 2008 Oct 2;455(7213):674-8
18724357
Mol Cell Biol. 2006 Dec;26(24):9220-31
17030611
Nat Rev Mol Cell Biol. 2007 Jul;8(7):519-29
17565364
Mol Cell Biol. 2008 Aug;28(16):5014-26
18559423
Traffic. 2008 Mar;9(3):281-9
17988219
Nat Immunol. 2009 May;10(5):480-7
19305394
Cell. 2005 May 20;121(4):567-577
15907470
Lancet Infect Dis. 2009 Nov;9(11):688-98
19850227
Cell Host Microbe. 2010 Feb 18;7(2):115-27
20159618
Amino Acids. 2010 May;38(5):1283-99
19882216
Cell. 2009 Aug 7;138(3):576-91
19631370
Nat Immunol. 2009 May;10(5):461-70
19381141
J Biol Chem. 2006 Oct 13;281(41):30373-82
16857678
Curr Biol. 2004 May 4;14(9):806-11
15120074
PLoS Pathog. 2007 Mar;3(3):e29
17335348