title: Disorders of hemostasis associated with chronic kidney disease.
abstract: Chronic kidney disease (CKD) is a growing global health problem. CKD is typically associated with a prothrombotic tendency in the early stages of the disease, whereas in its more advanced stage, that is, end-stage renal disease, patients suffer from a prothrombotic tendency and, in many cases, a bleeding diathesis. The exact etiology behind the coexistence of these conflicting hemostatic disorders is poorly understood. This review critically appraises studies examining the abnormalities in the hemostasis pathway in patients with CKD, as well as the therapeutic options that are currently available to treat these individuals.
authors.affiliation: Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, CO, USA.
authors.forename: Diana I
authors.initials: DI
authors.lastname: Jalal
authors.forename: Michel
authors.initials: M
authors.lastname: Chonchol
authors.forename: Giovanni
authors.initials: G
authors.lastname: Targher
mesh_terms: D001777:Blood Coagulation / Q000502:physiology; D001778:Blood Coagulation Disorders / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000209:etiology; D051436:Renal Insufficiency, Chronic / Q000150:complications*; D012084:Renin-Angiotensin System / Q000187:drug effects