title: Orthogonal 18F and 64Cu labelling of functionalised bis(thiosemicarbazonato) complexes.
abstract: The synthesis of three pairs of orthogonally labelled fluorinated Cu bis(thiosemicarbazonato) complexes is presented. These are the first examples of (18)F-labelled Cu(II)-complexes designed to serve as new hypoxia selective PET tracers and as mechanistic probes to study the mode of action of this class of markers. In vitro evaluation revealed that the fluorinated Cu-complex derived from amide coupling is suitable for in vivo work.
authors.affiliation: University of Oxford, Chemistry Research Laboratory, Mansfield Road, Oxford, UK.
authors.forename: Laurence
authors.initials: L
authors.lastname: Carroll
authors.forename: Romain
authors.initials: R
authors.lastname: Bejot
authors.forename: Rebekka
authors.initials: R
authors.lastname: Hueting
authors.forename: Robert
authors.initials: R
authors.lastname: King
authors.forename: Paul
authors.initials: P
authors.lastname: Bonnitcha
authors.forename: Simon
authors.initials: S
authors.lastname: Bayly
authors.forename: Martin
authors.initials: M
authors.lastname: Christlieb
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Dilworth
authors.forename: Antony D
authors.initials: AD
authors.lastname: Gee
authors.forename: Jérôme
authors.initials: J
authors.lastname: Declerck
authors.forename: Véronique
authors.initials: V
authors.lastname: Gouverneur
mesh_terms: D015687:Cell Hypoxia; D002460:Cell Line; D003301:Copper Radioisotopes / Q000737:chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry; D006801:Humans; D049268:Positron-Emission Tomography / Q000379:methods*; D013882:Thiosemicarbazones / Q000737:chemistry
chemical_list: D003301:Copper Radioisotopes; D005462:Fluorine Radioisotopes; D013882:Thiosemicarbazones