Imaging diagnosis--Neuronal ceroid lipofuscinosis with a chronic subdural hematoma.
A subdural hematoma was found to accompany neuronal ceroid lipofuscinosis in an 11-month-old Dachshund. Results from clinical, magnetic resonance (MR) imaging, histopathologic, ultrastructural, and molecular assessments are described. The dog had a 3-month history of progressive neurologic signs. In MR images, there was severe asymmetric cerebral atrophy with a subdural hematoma. Histopathologically, there was autofluorescent, periodic acid-Schiff-positive lipopigment in neurons and transmission electron microscopy confirmed a typical curvilinear profile of the storage bodies. We hypothesize that rapid brain atrophy contributed to the subdural hematoma formation, a complication not described previously in dogs with neuronal lipofuscinosis.
Asakawa
Midori Goto
MG
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA. midori_asakawa@ncsu.edu
MacKillop
Edward
E
Olby
Natasha J
NJ
Robertson
Ian D
ID
Cullen
John M
JM
D000818:Animals; D001344:Autopsy / Q000662:veterinary; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D004283:Dog Diseases / Q000175:diagnosis* / Q000209:etiology; D004285:Dogs; D037901:Euthanasia, Animal; D020200:Hematoma, Subdural, Chronic / Q000175:diagnosis / Q000209:etiology / Q000662:veterinary*; D008279:Magnetic Resonance Imaging / Q000662:veterinary*; D008297:Male; D009472:Neuronal Ceroid-Lipofuscinoses / Q000150:complications / Q000175:diagnosis / Q000662:veterinary*; D011859:Radiography