Human herpesvirus 6-A, 6-B, and 7 in vitreous fluid samples.
Human herpesvirus 6 and 7 (HHV-6, HHV-7) have been associated with several neurologic syndromes and have been detected in nervous tissue from healthy persons; however, only two cases of HHV-6A have been reported to be associated with intraocular inflammatory disease. Vitreous fluid was tested from 101 patients, including 69 samples from patients with ocular inflammation including CMV retinitis, idiopathic retinitis, iritis, and vitritis, for HHV-6A, HHV-6B, and HHV-7 DNA by PCR. HHV-6A DNA (4,950 copies per ml) was detected in vitreous fluid from one patient with CMV retinitis, HHV-6B DNA (10,140 copies per ml) was detected in vitreous fluid from one patient with idiopathic ocular inflammation in the absence of CMV DNA, and HHV-7 was not detected in any of the vitreous samples. HHV-6A, HHV-6B, and HHV-7 DNA are detectable in less than 2% of vitreous samples in patients with ocular inflammation.
Cohen
Jeffrey I
JI
Medical Virology Section, Laboratory of Clinical Infectious Diseases, National Institute for Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1888, USA. jcohen@niaid.nih.gov
Fahle
Gary
G
Kemp
Margaret A
MA
Apakupakul
Kathleen
K
Margolis
Todd P
TP
D004279:DNA, Viral / Q000302:isolation & purification; D005128:Eye Diseases / Q000821:virology*; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D016199:Herpesvirus 7, Human / Q000302:isolation & purification*; D006801:Humans; D016133:Polymerase Chain Reaction; D019349:Roseolovirus Infections / Q000821:virology*; D014822:Vitreous Body / Q000821:virology*
D004279:DNA, Viral