title: ACTH protects against glucocorticoid-induced osteonecrosis of bone.
abstract: We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the fine vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy.
authors.affiliation: The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA. mone.zaidi@mssm.edu
authors.forename: Mone
authors.initials: M
authors.lastname: Zaidi
authors.forename: Li
authors.initials: L
authors.lastname: Sun
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Robinson
authors.forename: Irina L
authors.initials: IL
authors.lastname: Tourkova
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Yujuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Ling-Ling
authors.initials: LL
authors.lastname: Zhu
authors.forename: Xuan
authors.initials: X
authors.lastname: Liu
authors.forename: Jianhua
authors.initials: J
authors.lastname: Li
authors.forename: Yuanzhen
authors.initials: Y
authors.lastname: Peng
authors.forename: Guozhe
authors.initials: G
authors.lastname: Yang
authors.forename: Xingming
authors.initials: X
authors.lastname: Shi
authors.forename: Alice
authors.initials: A
authors.lastname: Levine
authors.forename: Jameel
authors.initials: J
authors.lastname: Iqbal
authors.forename: Beatrice B
authors.initials: BB
authors.lastname: Yaroslavskiy
authors.forename: Carlos
authors.initials: C
authors.lastname: Isales
authors.forename: Harry C
authors.initials: HC
authors.lastname: Blair
mesh_terms: D016475:3T3 Cells; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D019610:Cytoprotection / Q000187:drug effects; D005260:Female; D005269:Femur / Q000187:drug effects / Q000473:pathology*; D005938:Glucocorticoids / Q000009:adverse effects*; D006801:Humans; D051379:Mice; D010006:Osteoblasts / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D010020:Osteonecrosis / Q000139:chemically induced* / Q000188:drug therapy* / Q000517:prevention & control; D020011:Protective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D011817:Rabbits; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis
chemical_list: D005938:Glucocorticoids; D020011:Protective Agents; D042461:Vascular Endothelial Growth Factor A; D000324:Adrenocorticotropic Hormone