title: Antibacterial surfaces by adsorptive binding of polyvinyl-sulphonate-stabilized silver nanoparticles.
abstract: This paper presents a novel and facile method for the generation of efficient antibacterial coatings which can be applied to practically any type of substrate. Silver nanoparticles were stabilized with an adsorbed surface layer of polyvinyl sulphonate (PVS). This steric layer provided excellent colloidal stability, preventing aggregation over periods of months. PVS-coated silver nanoparticles were bound onto amine-containing surfaces, here produced by deposition of an allylamine plasma polymer thin film onto various substrates. SEM imaging showed no aggregation upon surface binding of the nanoparticles; they were well dispersed on amine surfaces. Such nanoparticle-coated surfaces were found to be effective in preventing attachment of Staphylococcus epidermidis bacteria and also in preventing biofilm formation. Combined with the ability of plasma polymerization to apply the thin polymeric binding layer onto a wide range of materials, this method appears promising for the fabrication of a wide range of infection-resistant biomedical devices.
authors.affiliation: Mawson Institute, University of South Australia, Mawson Lakes Campus, Mawson Lakes, Adelaide, SA 5095, Australia. Krasimir.vasilev@unisa.edu.au
authors.forename: Krasimir
authors.initials: K
authors.lastname: Vasilev
authors.forename: Vasu R
authors.initials: VR
authors.lastname: Sah
authors.forename: Renee V
authors.initials: RV
authors.lastname: Goreham
authors.forename: Chi
authors.initials: C
authors.lastname: Ndi
authors.forename: Robert D
authors.initials: RD
authors.lastname: Short
authors.forename: Hans J
authors.initials: HJ
authors.lastname: Griesser
mesh_terms: D000327:Adsorption; D000588:Amines / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D011145:Polyvinyls / Q000737:chemistry* / Q000494:pharmacology; D012834:Silver / Q000737:chemistry*; D013212:Staphylococcus epidermidis / Q000187:drug effects; D013451:Sulfonic Acids / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties; D013816:Thermodynamics
chemical_list: D000588:Amines; D000900:Anti-Bacterial Agents; D011145:Polyvinyls; D013451:Sulfonic Acids; C008959:lyapolate; D012834:Silver