title: Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome.
abstract: Metabolic syndrome is associated with increased propensity for diabetes and cardiovascular disease. Low-grade inflammation is characteristic of metabolic syndrome. C-reactive protein, the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. This review outlines the role of high-sensitivity C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes.
authors.affiliation: University of California Davis Medical Center, Sacramento, CA 95817, USA.
authors.forename: Sridevi
authors.initials: S
authors.lastname: Devaraj
authors.forename: Simona
authors.initials: S
authors.lastname: Valleggi
authors.forename: David
authors.initials: D
authors.lastname: Siegel
authors.forename: Ishwarlal
authors.initials: I
authors.lastname: Jialal
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D018450:Disease Progression; D006801:Humans; D015994:Incidence; D007249:Inflammation / Q000097:blood / Q000150:complications; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D012307:Risk Factors
chemical_list: D002097:C-Reactive Protein