title: Insular cortex volume in established bipolar affective disorder: a preliminary MRI study.
abstract: This structural magnetic resonance imaging study investigated insular cortex volume in 26 patients with bipolar I disorder and 24 matched controls. While insular volume did not differ between these groups, exploratory analyses demonstrated that the number of depressive episodes correlated negatively with the anterior insular volume in the patients, suggesting it may have a role in the pathophysiology of bipolar disorder.
authors.affiliation: Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, 161 Barry Street, Carlton South, Victoria 3053, Australia. tsutomu@med.u-toyama.ac.jp
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Gin S
authors.initials: GS
authors.lastname: Malhi
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Wood
authors.forename: Murat
authors.initials: M
authors.lastname: Yücel
authors.forename: Mark
authors.initials: M
authors.lastname: Walterfang
authors.forename: Ryoichiro
authors.initials: R
authors.lastname: Tanino
authors.forename: Michio
authors.initials: M
authors.lastname: Suzuki
authors.forename: Christos
authors.initials: C
authors.lastname: Pantelis
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001714:Bipolar Disorder / Q000473:pathology*; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D055815:Young Adult