title: The t(14,15) in mouse strain CBA/CaH-T(14;15)6Ca/J causes a break in the ADAMTS12 gene.
abstract: The mouse strain CBA/CaH-T(14;15)6Ca/J carries a homozygous balanced reciprocal translocation between mouse chromosomes 14 and 15, but the break points of this translocation have not previously been examined in detail. Using fluorescent in situ hybridization, we assigned the break point in 14qE3 to a 200-kb region devoid of any known gene. We similarly defined the break point in 15qA1 to a 27-kb region containing involving ADAMTS12. The chromosomal break likely is between exons 2 and 3 of ADAMTS12. This gene encodes a disintegrin and metalloproteinase with thrombospondin motifs, and this product plays crucial roles in both vascularization and cancer progression and has been implicated in the development of arthritis. The CBA/CaH-T(14;15)6Ca/J mouse strain likely is a suitable model for further examination of the influences of defective ADAMTS12 in various pathologic processes.
authors.affiliation: Clinic of Gynecology and Obstetrics, University Clinic Schleswig-Holstein, Campus Kiel, Kiel, Germany.
authors.forename: Bengi
authors.initials: B
authors.lastname: Acar-Perk
authors.forename: Karen
authors.initials: K
authors.lastname: Bräutigam
authors.forename: Regina
authors.initials: R
authors.lastname: Grunewald
authors.forename: Andreas
authors.initials: A
authors.lastname: Schmutzler
authors.forename: Christian
authors.initials: C
authors.lastname: Schem
authors.forename: Norbert K
authors.initials: NK
authors.lastname: Arnold
authors.forename: Walter
authors.initials: W
authors.lastname: Jonat
authors.forename: Jörg
authors.initials: J
authors.lastname: Weimer
mesh_terms: D051722:ADAM Proteins / Q000235:genetics* / Q000378:metabolism; D000071096:ADAMTS Proteins; D000818:Animals; D002478:Cells, Cultured; D019457:Chromosome Breakage; D033481:Chromosomes, Mammalian; D004195:Disease Models, Animal; D005091:Exons; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains
chemical_list: D051722:ADAM Proteins; D000071096:ADAMTS Proteins; C550048:Adamts12 protein, mouse