Modelling drug-eluting stents.
In this study, we consider a family of mathematical models to describe the elution of drug from polymer-coated stents into the arterial wall. Our models include the polymer layer, the media, the adventitia, a possible topcoat polymer layer and atherosclerotic plaque. We investigate the relative importance of transmural convection, diffusion and drug-dependent parameters in drug delivery and deposition. Furthermore, we investigate how the release rate from the stent can be altered and examine the resulting effect on cellular drug concentrations.
McGinty
Sean
S
Department of Mathematics and Statistics, University of Strathclyde, 26 Richmond Street, Glasgow G1 1XH, UK. rs.smcg@maths.strath.ac.uk
McKee
Sean
S
Wadsworth
Roger M
RM
McCormick
Christopher
C
D002339:Carotid Arteries / Q000187:drug effects / Q000378:metabolism*; D054855:Drug-Eluting Stents; D020342:Finite Element Analysis; D006801:Humans; D008955:Models, Cardiovascular; D058226:Plaque, Atherosclerotic / Q000378:metabolism* / Q000628:therapy