title: Spectroscopic characterization and biological activity of Zn(II), Cd(II), Sn(II) and Pb(II) complexes with Schiff base derived from pyrrole-2-carboxaldehyde and 2-amino phenol.
abstract: A new Schiff base 2-aminophenol-pyrrole-2-carboxaldehyde and its Zn(II), Cd(II), Sn(II) and Pb(II) complexes have been synthesized and characterized by various physicochemical studies. Spectral studies (IR and (1)H NMR) indicate deprotonation and coordination of phenolic oxygen along with binding of pyrrole nitrogen, azomethine nitrogen and anion with metal ions. The presence of lattice water molecule(s) has also been confirmed by TG/DTA studies. Mass spectrum explains the successive degradation of the molecular species in solution and justifies ML complexes. Kinetic and thermodynamic parameters were computed from the thermal data using Coats and Redfern method, which confirm first order kinetics. The bio-efficacy of the ligand and their complexes has been examined against the growth of bacteria in vitro to evaluate their antimicrobial potential. Molecular structures of the complexes have been optimized by MM2 calculations and suggest a tetrahedral geometry around metal ions.
authors.affiliation: Inorganic & Bioinorganic Research Lab, Department of Chemistry, Govt. Post Graduate College, Ranikhet 263645, Uttarakhand, India. bibheshksingh@yahoo.co.in
authors.forename: Bibhesh K
authors.initials: BK
authors.lastname: Singh
authors.forename: Anant
authors.initials: A
authors.lastname: Prakash
authors.forename: Hemant K
authors.initials: HK
authors.lastname: Rajour
authors.forename: Narendar
authors.initials: N
authors.lastname: Bhojak
authors.forename: Devjani
authors.initials: D
authors.lastname: Adhikari
mesh_terms: D000627:Aminophenols / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002104:Cadmium / Q000737:chemistry / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D007854:Lead / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D011758:Pyrroles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D014001:Tin / Q000737:chemistry / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000627:Aminophenols; D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D011758:Pyrroles; D012545:Schiff Bases; D002104:Cadmium; C051266:pyrrole-2-carboxaldehyde; C027667:2-aminophenol; D007854:Lead; D014001:Tin; D015032:Zinc