Carvedilol stability in paediatric oral liquid formulations.
OBJECTIVE
Two carvedilol aqueous solutions and one carvedilol aqueous suspension for paediatric oral use (1mg/ml) were studied to determine their stability.


METHODS
All samples were stored at 4, 25 and 40°C. Carvedilol content of each of the three formulations was tested using high performance liquid chromatography (HPLC). Each sample was analysed in triplicate at 0, 3, 7, 14, 28 and 56 days.


RESULTS
Carvedilol stayed stable in the acidic aqueous solution at the three different temperatures during the 56 days of the study. In the alkaline solution, carvedilol was stable during 56 days at 25°C, but only 28 days at 4 and 40°C. In the aqueous suspension, carvedilol was stable during 56 days at 4 and 25°C, but only 28 days at 40°C.


CONCLUSIONS
All the formulations that were tested can be stored at 25°C for at least 56 days.
Buontempo
F
F
Department of Pharmaceutical Technology, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina.
Bernabeu
E
E
Glisoni
R J
RJ
Quiroga
E
E
Bregni
C
C
Chiappetta
D A
DA
D000284:Administration, Oral; D002227:Carbazoles / Q000008:administration & dosage / Q000494:pharmacology*; D000077261:Carvedilol; D002648:Child; D004355:Drug Stability; D006801:Humans; D019999:Pharmaceutical Solutions; D011412:Propanolamines / Q000008:administration & dosage / Q000494:pharmacology*; D013535:Suspensions
D002227:Carbazoles; D019999:Pharmaceutical Solutions; D011412:Propanolamines; D013535:Suspensions; D000077261:Carvedilol