title: Vitamin E ameliorates high dose trans-dehydrocrotonin-associated hepatic damage in mice.
abstract: trans-Dehydrocrotonin (t-DCTN), the diterpenoid from Croton cajucara Bentham, exhibits hypoglycemic and hypolipidemic activities, but in high doses is associated with a discrete hepatotoxicity. In the search for measures to mitigate this, pretreatment with the antioxidants N-acetylcysteine and vitamin E has been examined. Mice that received a high dose t-DCTN (100 mg/kg) manifested hepatic damage, as evidenced by significant elevations in serum ALT and AST, and hepatic GSH, and histological alterations, which could be obliterated by pretreatment with vitamin E, but not with N-acetylcysteine, possibly by creating an effective antioxidant balance.
authors.affiliation: Departament of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil.
authors.forename: Alana Fontales Lima
authors.initials: AF
authors.lastname: Rabelo
authors.forename: Marjorie Moreira
authors.initials: MM
authors.lastname: Guedes
authors.forename: Adriana da Rocha
authors.initials: Ada R
authors.lastname: Tomé
authors.forename: Patricia Rodrigues
authors.initials: PR
authors.lastname: Lima
authors.forename: Maria Aparecida
authors.initials: MA
authors.lastname: Maciel
authors.forename: Silveria Regina de Sousa
authors.initials: SR
authors.lastname: Lira
authors.forename: Ana Carla da Silva
authors.initials: AC
authors.lastname: Carvalho
authors.forename: Flávia Almeida
authors.initials: FA
authors.lastname: Santos
authors.forename: Vietla Satyanarayana
authors.initials: VS
authors.lastname: Rao
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D002374:Catalase / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000201:enzymology / Q000517:prevention & control*; D045785:Diterpenes, Clerodane / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004347:Drug Interactions; D005978:Glutathione / Q000032:analysis; D006651:Histocytochemistry; D008297:Male; D051379:Mice; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D045785:Diterpenes, Clerodane; D017392:Thiobarbituric Acid Reactive Substances; C103060:dehydrocrotonin; D014810:Vitamin E; D002374:Catalase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; D000111:Acetylcysteine