title: Caged mitochondrial uncouplers that are released in response to hydrogen peroxide.
abstract: Caged versions of the most common mitochondrial uncouplers (proton translocators) have been prepared that sense the reactive oxygen species (ROS) hydrogen peroxide to release the uncouplers 2,4-dinitrophenol (DNP) and carbonylcyanide p-trifluoromethoxyphenylhydrazone (FCCP) from caged states with second order rate constants of 10 (+/-0.8) M(-1) s(-1) and 64.8 (+/-0.6) M(-1) s(-1), respectively. The trigger mechanism involves conversion of an arylboronate into a phenol followed by fragmentation. Hydrogen peroxide-activated uncouplers may be useful for studying the biological process of ageing.
authors.affiliation: Centre for the Chemical Research of Ageing, WestCHEM Department of Chemistry, University of Glasgow, Glasgow G12 8QQ, United Kingdom.
authors.forename: Caroline
authors.initials: C
authors.lastname: Quin
authors.forename: Linsey
authors.initials: L
authors.lastname: Robertson
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: McQuaker
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Price
authors.forename: Martin D
authors.initials: MD
authors.lastname: Brand
authors.forename: Richard C
authors.initials: RC
authors.lastname: Hartley