title: [The supplementation of L-carnitine does not promote alterations in the resting metabolic rate and in the use of energetic substrates in physically active individuals].
abstract: OBJECTIVE
  To investigate the effects of L-carnitine supplementation, over thirty days, on the resting metabolic rate (RMR) and oxidation of free fatty acids (FFA) under rested or exercised conditions.
  
  
  METHODS
  Twenty-one overweight active volunteers (40 to 58 years old) were randomized into two groups: supplemented (GS; N = 11; 1,8 g/day of L-carnitine) or placebo (GP; N = 10; maltodextrin). Caloric intake, anthropometry, RMR, VO(2max), respiratory exchange ratio and plasma FFA were measured.
  
  
  RESULTS
  No significant changes were found in the caloric intake (-244,66 vs. -126,00 kcal/day), body composition (-0.07 vs. -0.17 kg/m(2)), RMR (0.06 vs. -0.02 kcal/day), respiratory exchange ratio at rest (3.69 vs. -1.01) and exercise (0.01 vs. -0.01) or VO(2max) (0.50 vs. 1.25 mL/kg/min) between GS and GP. Plasma FFA levels were increased under resting conditions only in the GP group (0.27), but no significant changes were observed before or after physical activity in any of the groups.
  
  
  CONCLUSIONS
  Supplementation with L-carnitine caused no changes in the variables analyzed in this study.
authors.affiliation: Programa de Pós-graduação em Nutrição Humana Aplicada, Universidade de São Paulo, Brasil. christianne.coelho@hotmail.com
authors.forename: Christianne de
authors.initials: Cd
authors.lastname: Faria Coelho
authors.forename: João Felipe
authors.initials: JF
authors.lastname: Mota
authors.forename: Fabrício César de
authors.initials: FC
authors.lastname: Paula Ravagnani
authors.forename: Roberto Carlos
authors.initials: RC
authors.lastname: Burini
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001481:Basal Metabolism / Q000187:drug effects* / Q000502:physiology; D002331:Carnitine / Q000008:administration & dosage*; D015444:Exercise / Q000502:physiology*; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000188:drug therapy*; D012146:Rest / Q000502:physiology*; D018709:Statistics, Nonparametric
chemical_list: D005227:Fatty Acids; D002331:Carnitine