title: Enantiomeric separation of cis-bifenthrin by CD-MEKC: quantitative analysis in a commercial insecticide formulation.
abstract: The first CE method enabling the enantiomeric separation of the synthetic pyrethroid cis-bifenthrin (BF) was developed in this work. CD-MEKC was the CE mode employed for this purpose. The influence of several experimental parameters such as temperature, voltage, type and concentration of surfactant (chiral and achiral) and CD was investigated. The use of the bile salt sodium cholate at a concentration of 100 mM in the presence of 20 mM heptakis (2,3,6-tri-O-methyl)-beta-CD enabled the separation of cis-BF enantiomers in less than 10 min and with a resolution of 2.8. The analytical characteristics of the developed methodology were evaluated allowing its application to the quantitation of cis-BF in a polyvalent commercial insecticide formulation.
authors.affiliation: Department of Analytical Chemistry, Faculty of Chemistry, University of Alcalá, Madrid, Spain.
authors.forename: Virginia
authors.initials: V
authors.lastname: Pérez-Fernández
authors.forename: Maria Angeles
authors.initials: MA
authors.lastname: García
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Marina
mesh_terms: D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification*; D016014:Linear Models; D011722:Pyrethrins / Q000737:chemistry / Q000302:isolation & purification*; D015203:Reproducibility of Results; D020358:Sodium Cholate / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D007306:Insecticides; D011722:Pyrethrins; D047392:beta-Cyclodextrins; C000609658:heptakis(2,3,6-tri-O-methyl)-beta-cyclodextrin; C038119:heptakis(2,6-O-dimethyl)beta-cyclodextrin; C099952:bifenthrin; D020358:Sodium Cholate