Regulation of RNA polymerase II elongation by c-Myc.
The genome-wide mapping presented in this issue by Rahl et al. (2010) demonstrates how the transcription factor c-Myc interfaces with the machinery that controls RNA polymerase II elongation. These findings account for the ability of c-Myc to activate the expression of a large number of genes that promote rapid proliferation.
Price
David H
DH
Biochemistry Department, University of Iowa, Iowa City, IA 52242, USA. david-price@uiowa.edu