title: Bilateral progressive cystic nephroma in a 9-month-old male infant requiring renal replacement therapy.
abstract: We report the case of a 3-year-old boy who presented at 9 months of age with abdominal distension and was found to have a triad of bilateral cystic nephroma, pleuropulmonary blastoma (PPB) and juvenile intestinal polyps. There have been three previous reported cases of patients with the same associated diagnoses. Our patient is the first reported patient with PPB who received renal replacement therapy and progressed to successful renal transplantation. The potential increased risk of progression of malignancy of PPB (type 1) with immunosuppression following transplantation remains unknown.
authors.affiliation: Department of Paediatric Nephrology, St. James's University Hospital, Leeds LS9 7TF, UK. ihab.shaheen@doctors.org.uk
authors.forename: Ihab Sakr
authors.initials: IS
authors.lastname: Shaheen
authors.forename: Maggie
authors.initials: M
authors.lastname: Fitzpatrick
authors.forename: Keith
authors.initials: K
authors.lastname: Brownlee
authors.forename: Nikhil
authors.initials: N
authors.lastname: Bhuskute
authors.forename: Martin
authors.initials: M
authors.lastname: Elliott
authors.forename: Mark
authors.initials: M
authors.lastname: Powis
authors.forename: Niaz
authors.initials: N
authors.lastname: Ahmad
authors.forename: Kay
authors.initials: K
authors.lastname: Tyerman
mesh_terms: D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007417:Intestinal Polyps / Q000150:complications; D007680:Kidney Neoplasms / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D016030:Kidney Transplantation; D008175:Lung Neoplasms / Q000150:complications; D008297:Male; D018297:Neoplasms, Cystic, Mucinous, and Serous / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D009378:Neoplasms, Multiple Primary; D010997:Pleural Neoplasms / Q000150:complications; D018202:Pulmonary Blastoma / Q000150:complications; D017582:Renal Replacement Therapy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome