[Neutrophilic inflammation--indicative of asthma severity].
Our main aim in this study was to investigate the number of neutrophils at the bronchial mucosae level in patients diagnosed with bronchial asthma.


METHODS
We examined a number of 21 patients with different level of severity of asthma (according to GINA). Fragments of bronchial mucosae were obtained through fiberbronchoscopy, prepared for histological examination for performing the immune staining with anti-elastase antibodies.


RESULTS
We found significantly higher number of neutrophils at microscopic examination in the patients with severe asthma than in healthy subjects or mild asthma subjects (r = 0.79, p < 0.01).


CONCLUSIONS
The results of this study suggest that neutrophils can be considered a specific lesion in patients with severe bronchial asthma.
Grigoraş
Adriana
A
Universitatea de Medicină si Farmacie Gr. T. Popa, Iaşi.
Grigoraş
Constantin-Cristian
CC
Mihaescus
Traian
T
Floarea-Strat
Alina
A
Andriescu
Corina
C
Cotutiu
Coriolan
C
D000328:Adult; D001249:Asthma / Q000276:immunology* / Q000473:pathology*; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D001999:Bronchoscopy; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D012720:Severity of Illness Index
D015415:Biomarkers