title: Monomorphic epithelial proliferations of the breast: a possible precursor lesion associated with ipsilateral breast failure after breast conserving therapy in patients with negative lumpectomy margins.
abstract: BACKGROUND
  It is generally believed that ipsilateral breast failures (IBFs) after breast-conserving therapy (BCT) develop from incompletely eradicated carcinoma. We previously suggested that monomorphic epithelial proliferations (MEPs) in the breast may be a pool of partially transformed clones from which breast carcinomas can arise and that radiation therapy (RT) may also reduce the risk of IBF by eradicating MEPs. We examined salvage mastectomy specimens in patients experiencing an IBF to define the relationship between MEPs and IBFs and an additional potential mechanism for IBF risk reduction by RT.
  
  
  METHODS
  The location, number, and distribution of radiation changes and MEPs relative to 51 IBFs were mapped in salvage mastectomy specimens from BCT patients with adequately excised, initial carcinomas (negative lumpectomy margins).
  
  
  RESULTS
  All 51 salvage mastectomies had diffuse, late radiation changes. None had active fibrocystic lesions. MEPs were predominantly located in the immediate vicinity of the IBFs. A mean of 39% of MEP cases were located within the IBF, 46% were located within 2 cm of the IBF, and 14% were 2-3 cm from the IBF.
  
  
  CONCLUSIONS
  MEPs appear to be a pool of partially transformed precursor lesions that can give rise to ductal carcinoma in situ and invasive carcinomas (CAs). Many IBFs may arise from MEPs that reemerge after RT. Radiation may also reduce IBF risk after BCT (including in patients with negative margins) by primarily eradicating MEPs.
authors.affiliation: Advanced Diagnostics Laboratory, Redford, MI, USA.
authors.forename: Neal S
authors.initials: NS
authors.lastname: Goldstein
authors.forename: Larry L
authors.initials: LL
authors.lastname: Kestin
authors.forename: Frank A
authors.initials: FA
authors.lastname: Vicini
mesh_terms: D001940:Breast / Q000473:pathology* / Q000528:radiation effects / Q000601:surgery; D001943:Breast Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D049109:Cell Proliferation; D004847:Epithelial Cells / Q000473:pathology / Q000528:radiation effects; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental / Q000379:methods; D018365:Neoplasm, Residual; D016609:Neoplasms, Second Primary / Q000473:pathology* / Q000517:prevention & control / Q000601:surgery; D011230:Precancerous Conditions / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D016879:Salvage Therapy / Q000379:methods