Probiotics and intestinal colonization by vancomycin-resistant enterococci in mice and humans.
We investigated the impact of probiotics on the intestinal carriage of vancomycin-resistant enterococci (VRE). Administration of Lactobacillus rhamnosus Lcr35 but not Escherichia coli Nissle reduced, although not significantly, the density of VRE colonization in a murine model. No effect of Lcr35 was observed in a double-blind placebo randomized study, involving nine patients.
Vidal
Magali
M
Service des maladies infectieuses et tropicales, CHU Clermont-Ferrand, Clermont-Ferrand, France.
Forestier
Christiane
C
Charbonnel
Nicolas
N
Henard
Sandrine
S
Rabaud
Christian
C
Lesens
Olivier
O
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002353:Carrier State / Q000382:microbiology / Q000503:physiopathology; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D004311:Double-Blind Method; D004587:Electrophoresis, Agar Gel; D016983:Enterococcus / Q000187:drug effects*; D004926:Escherichia coli; D005243:Feces / Q000382:microbiology; D006801:Humans; D052201:Lacticaseibacillus rhamnosus; D051379:Mice; D008875:Middle Aged; D010802:Phylogeny; D010865:Pilot Projects; D019936:Probiotics / Q000627:therapeutic use*; D014640:Vancomycin / Q000009:adverse effects / Q000494:pharmacology; D020713:Vancomycin Resistance / Q000187:drug effects*
D014640:Vancomycin