title: Mn(II), Co(II) and Zn(II) complexes with heterocyclic substituted thiosemicarbazones: synthesis, characterization, X-ray crystal structures and antitumor comparison.
abstract: Transition metal complexes Mn(L(1))(2) (1), Mn(L(2))(2) (2), Co(L(3))(2)Cl 4H(2)O (3), Zn(L(3))(2) DMF (4), Co(HL(4))(2)(ClO(4))(2) 3H(2)O (5) and Zn(L(5))(2) DMF (6) where HL(1)=2-acetylpyridine thiosemicarbazone, HL(2)=2-acetylpyridine N(4)-methylthiosemicarbazone, HL(3)=2-benzoylpyridine thiosemicarbazone, HL(4)=2-benzoylpyridine N(4)-methylthiosemicarbazone and HL(5)=2-benzoylpyridine N(4)-phenylthiosemicarbazone, have been synthesized. The complexes 1, 2, 5 and 6 were characterized by elemental analysis, IR spectra and single-crystal X-ray diffraction studies. Preliminary in vitro screening indicated that all the tested compounds showed significant antitumor activity against K562 leucocythemia cancer cell line.
authors.affiliation: Institute of Molecular and Crystal Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475001, P.R. China.
authors.forename: Ming Xue
authors.initials: MX
authors.lastname: Li
authors.forename: Chun Ling
authors.initials: CL
authors.lastname: Chen
authors.forename: Dong
authors.initials: D
authors.lastname: Zhang
authors.forename: Jing Yang
authors.initials: JY
authors.lastname: Niu
authors.forename: Bian Sheng
authors.initials: BS
authors.lastname: Ji
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D003035:Cobalt / Q000737:chemistry; D018360:Crystallography, X-Ray; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006801:Humans; D006860:Hydrogen Bonding; D020014:K562 Cells; D008345:Manganese / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013882:Thiosemicarbazones / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D013882:Thiosemicarbazones; D003035:Cobalt; D008345:Manganese; D015032:Zinc