title: A closer look at the structure of sterically stabilized liposomes: a small-angle X-ray scattering study.
abstract: The evaluation of the radial electron density profile of a drug containing a sterically stabilized liposomal system is described. Using synchrotron small-angle X-ray scattering, we were able to characterize the hydrophilic shell of the polyethylene glycol chains. Using a Gaussian model for describing the electron density profile along the normal of the bilayer, we got an asymmetric distribution of PEGylated lipids in accordance with theoretical considerations. Moreover, we used anomalous X-ray scattering to study the localization of a hydrophobic drug (a kinase inhibitor), which revealed that these molecules are mainly located in the hydrocarbon chain region of the phospholipid bilayer.
authors.affiliation: Institute of Nanochemistry and Catalysis, Chemical Research Center, Hungarian Academy of Sciences, Pusztaszeri út 59-67, H-1025 Budapest, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Varga
authors.forename: Szilvia
authors.initials: S
authors.lastname: Berényi
authors.forename: Bálint
authors.initials: B
authors.lastname: Szokol
authors.forename: László
authors.initials: L
authors.lastname: Orfi
authors.forename: György
authors.initials: G
authors.lastname: Kéri
authors.forename: István
authors.initials: I
authors.lastname: Peták
authors.forename: Armin
authors.initials: A
authors.lastname: Hoell
authors.forename: Attila
authors.initials: A
authors.lastname: Bóta
mesh_terms: D008081:Liposomes / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D053838:Scattering, Small Angle; D014961:X-Ray Diffraction
chemical_list: D008081:Liposomes; D010713:Phosphatidylcholines; D011092:Polyethylene Glycols; C028694:1-palmitoyl-2-oleoylphosphatidylcholine