title: Oxygen-independent photonuclease activity of a new iron(II) complex.
abstract: A new iron(ii) complex was synthesized and its photonuclease activity against plasmid DNA was evaluated. After kinetic experiments a k(cat) of 18.86 +/- 2.9 h(-1) was obtained, one of the highest nuclease activities of synthetic metallonucleases, selectively activated by 365 nm UV light.
authors.affiliation: Departamento de Química, Universidade Federal de Santa Catarina, 88040-900, Florianópolis, SC, Brazil.
authors.forename: Bernardo
authors.initials: B
authors.lastname: de Souza
authors.forename: Fernando R
authors.initials: FR
authors.lastname: Xavier
authors.forename: Rosely A
authors.initials: RA
authors.lastname: Peralta
authors.forename: Adailton J
authors.initials: AJ
authors.lastname: Bortoluzzi
authors.forename: Gilmar
authors.initials: G
authors.lastname: Conte
authors.forename: Hugo
authors.initials: H
authors.lastname: Gallardo
authors.forename: Franciele L
authors.initials: FL
authors.lastname: Fischer
authors.forename: Giselle
authors.initials: G
authors.lastname: Bussi
authors.forename: Hernán
authors.initials: H
authors.lastname: Terenzi
authors.forename: Ademir
authors.initials: A
authors.lastname: Neves
mesh_terms: D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D053837:DNA Cleavage; D003851:Deoxyribonucleases / Q000737:chemistry / Q000378:metabolism; D005296:Ferrous Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D010100:Oxygen / Q000737:chemistry*; D010782:Photolysis; D010957:Plasmids / Q000737:chemistry; D014466:Ultraviolet Rays
chemical_list: D005296:Ferrous Compounds; D008024:Ligands; D004247:DNA; D003851:Deoxyribonucleases; D010100:Oxygen