title: p53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss.
abstract: The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function.
authors.affiliation: Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel. ran.brosh@weizmann.ac.il
authors.forename: Ran
authors.initials: R
authors.lastname: Brosh
authors.forename: Rachel
authors.initials: R
authors.lastname: Sarig
authors.forename: Elad Bar
authors.initials: EB
authors.lastname: Natan
authors.forename: Alina
authors.initials: A
authors.lastname: Molchadsky
authors.forename: Shalom
authors.initials: S
authors.lastname: Madar
authors.forename: Chamutal
authors.initials: C
authors.lastname: Bornstein
authors.forename: Yosef
authors.initials: Y
authors.lastname: Buganim
authors.forename: Tirosh
authors.initials: T
authors.lastname: Shapira
authors.forename: Naomi
authors.initials: N
authors.lastname: Goldfinger
authors.forename: Ralf
authors.initials: R
authors.lastname: Paus
authors.forename: Varda
authors.initials: V
authors.lastname: Rotter
mesh_terms: D000505:Alopecia / Q000235:genetics*; D016923:Cell Death / Q000235:genetics; D005786:Gene Expression Regulation; D016158:Genes, p53 / Q000235:genetics*; D015533:Transcriptional Activation; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000502:physiology*; D053340:Xedar Receptor / Q000378:metabolism*
chemical_list: D016159:Tumor Suppressor Protein p53; D053340:Xedar Receptor