title: Developing an anion host for lipid A binding and antibacterial activity.
abstract: New structural amphiphiles 2a and 2b bind the diphosphate lipid A anion and show potential as lead compounds for the development of novel antibacterial agents.
authors.affiliation: School of Life and Environmental Sciences, Deakin University, Geelong, 3217, VIC, Australia.
authors.forename: Luke C
authors.initials: LC
authors.lastname: Henderson
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Roger L
authors.initials: RL
authors.lastname: Nation
authors.forename: Tony
authors.initials: T
authors.lastname: Velkov
authors.forename: Frederick M
authors.initials: FM
authors.lastname: Pfeffer
mesh_terms: D000151:Acinetobacter Infections / Q000188:drug therapy; D040981:Acinetobacter baumannii / Q000187:drug effects; D000838:Anions / Q000737:chemistry / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D008050:Lipid A / Q000737:chemistry / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013501:Surface-Active Agents / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000838:Anions; D000900:Anti-Bacterial Agents; D008050:Lipid A; D013501:Surface-Active Agents