Ovarian stimulation retards postimplantation development and alters global gene expression profile of blastocysts in mouse.
This study compares the quality, developmental capacity and global gene expression profile of embryos generated from superovulated and natural cycles. We found that ovarian stimulation impaired quality of blastocysts (cell number: 68.9 +/- 6.9 vs. 76.8 +/- 7.9; diameter of blastocysts: 145.3 +/- 76.9 microm vs. 152.6 +/- 65.5 microm), fetus development (rate of development to term: 45.5% vs. 69.1%; weight of 18.5-dpc fetuses: 1.23 +/- 0.03 g vs. 1.34 +/- 0.03 g) and caused 92 genes differentially expressed.
Zhang
Xinyan
X
Department of Obstetrics and Gynecology, General Hospital of the People's Liberation Army, Beijing, People's Republic of China.
Wang
Li
L
Li
Xiuli
X
Li
Ke
K
Fang
Jing
J
Yao
Yuanqing
Y
D000818:Animals; D001755:Blastocyst / Q000502:physiology*; D010064:Embryo Implantation; D004622:Embryo, Mammalian; D047108:Embryonic Development; D020869:Gene Expression Profiling; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D010062:Ovulation Induction