title: [Deep brain stimulation for Parkinson's disease].
abstract: Deep brain stimulation (DBS) is an effective neurosurgical therapy for treatment of motor symptoms in Parkinson's disease (PD). DBS of the subthalamic nucleus (STN-DBS) leads to a significant reduction of hypokinetic and hyperkinetic symptoms and improvement in quality of life. STN-DBS is, however, associated with severe adverse effects including psychiatric symptoms, such as depression, apathy and increased suicidal tendencies. Pallidal DBS might be just as efficacious with fewer adverse effects. Future studies will prospectively compare the clinical effects of STN and pallidal DBS. Alternative targets for treatment of PD have to be considered including the pedunculopontine nucleus, thalamic CM/Pf complex and zona incerta.
authors.affiliation: Klinik für Neurologie, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Schittenhelmstrasse 10, Kiel, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Herzog
authors.forename: G
authors.initials: G
authors.lastname: Deuschl
mesh_terms: D000978:Antiparkinson Agents / Q000627:therapeutic use; D001479:Basal Ganglia / Q000503:physiopathology; D003131:Combined Modality Therapy; D046690:Deep Brain Stimulation / Q000009:adverse effects / Q000523:psychology; D005917:Globus Pallidus / Q000503:physiopathology; D006801:Humans; D020646:Intralaminar Thalamic Nuclei / Q000503:physiopathology; D001523:Mental Disorders / Q000209:etiology / Q000503:physiopathology; D010300:Parkinson Disease / Q000503:physiopathology / Q000523:psychology / Q000628:therapy*; D045042:Pedunculopontine Tegmental Nucleus / Q000503:physiopathology; D017397:Prefrontal Cortex / Q000503:physiopathology; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D020531:Subthalamic Nucleus / Q000503:physiopathology
chemical_list: D000978:Antiparkinson Agents