Longitudinal study of the diagnosis of components of the metabolic syndrome in individuals with binge-eating disorder.
BACKGROUND
Binge-eating disorder may represent a risk factor for the metabolic syndrome.


OBJECTIVE
The objective was to assess longitudinally the relation between binge-eating disorder and components of the metabolic syndrome.


METHODS
At 2.5 and 5 y of follow-up, 134 individuals with binge-eating disorder and 134 individuals with no history of eating disorders, who were frequency-matched for age, sex, and baseline body mass index (BMI), were interviewed during the follow-up interval regarding new diagnoses of 3 metabolic syndrome components: hypertension, dyslipidemia, and type 2 diabetes.


RESULTS
A comparison of individuals with and without a binge-eating disorder in analyses adjusted for age, sex, baseline BMI, and interval BMI change had hazard ratios (95% CIs) for reporting new diagnoses of metabolic syndrome components of 2.2 (1.2, 4.2; P = 0.023) for dyslipidemia, 1.5 (0.76, 2.9; P = 0.33) for hypertension, 1.6 (0.77, 3.9; P = 0.29) for type 2 diabetes, 1.7 (1.1, 2.6; P = 0.023) for any component, and 2.4 (1.1, 5.7; P = 0.038) for > or =2 components.


CONCLUSIONS
Binge-eating disorder may confer a risk of components of the metabolic syndrome over and above the risk attributable to obesity alone. This trial was registered at www.clinicaltrials.gov as NCT00777634.
Hudson
James I
JI
McLean Hospital, Belmont, MA 02478, USA. jhudson@mclean.harvard.edu <jhudson@mclean.harvard.edu>
Lalonde
Justine K
JK
Coit
Caitlin E
CE
Tsuang
Ming T
MT
McElroy
Susan L
SL
Crow
Scott J
SJ
Bulik
Cynthia M
CM
Hudson
Margo S
MS
Yanovski
Jack A
JA
Rosenthal
Norman R
NR
Pope
Harrison G
HG
D000328:Adult; D056912:Binge-Eating Disorder / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000378:metabolism; D050171:Dyslipidemias / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000378:metabolism; D007407:Interviews as Topic; D053208:Kaplan-Meier Estimate; D008137:Longitudinal Studies; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000378:metabolism; D008875:Middle Aged