title: Enantioanalysis of (-)butaclamol using vancomycin and teicoplanin as chiral selectors.
abstract: Butaclamol is an antipsychotic drug used in the treatment of schizophrenia. The macrocyclic antibiotics, vancomycin and teicoplanin, are proposed as chiral selectors for the design of the enantioselective, potentiometric membrane electrodes (EPMEs) for the assay of (-)butaclamol. The slopes of the electrodes are near-Nernstian for the assay of (-) butaclamol with linear concentration ranges between 10(-10) and 10(-7) mol/L and between 10(-9) and 10(-7) mol/L for vancomycin and teicoplanin based EPMEs. Limits of detections varied. The electrodes were used reliably for the enantioanalysis of (-) butaclamol in serum samples.
authors.affiliation: National Institute of Research for Electrochemistry and Condensed Matter, Bucharest, Romania. iustinavanstaden@yahoo.com
authors.forename: Raluca-Ioana
authors.initials: RI
authors.lastname: Stefan-van Staden
authors.forename: Nontete Suzan
authors.initials: NS
authors.lastname: Nhlapo
authors.forename: Jacobus Frederick
authors.initials: JF
authors.lastname: van Staden
authors.forename: Hassan Y
authors.initials: HY
authors.lastname: Aboul-Enein
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000737:chemistry; D014150:Antipsychotic Agents / Q000032:analysis* / Q000737:chemistry*; D002069:Butaclamol / Q000032:analysis* / Q000737:chemistry*; D004566:Electrodes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D011199:Potentiometry; D013237:Stereoisomerism; D017334:Teicoplanin / Q000032:analysis* / Q000737:chemistry; D014640:Vancomycin / Q000032:analysis* / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D014150:Antipsychotic Agents; D017334:Teicoplanin; D014640:Vancomycin; D002069:Butaclamol