title: Biomedical exploitation of the fungus-growing ant symbiosis.
abstract: There is a constant need for discovering novel sources of compounds with antimicrobial properties, and recent studies support that symbiotic associations involving chemically mediated interactions may be a prominent source of novel compound discovery. Here I review a particularly promising natural system involving such interactions, the multipartite fungus-growing ant symbiosis. This includes a review of the ancient symbiosis involving intricate interactions between at least six symbionts, a review of the efforts that have been made in examining host-symbiont and symbiont-symbiont interactions, as well as the efforts made in identifying and characterizing chemical compounds mediating these interactions. Finally, I outline the prospects for future natural product discoveries from the system, touching on how advances in chemical analyses and whole-genome sequencing techniques will facilitate the process of natural product discovery of biomedical interest.
authors.affiliation: Department of Bacteriology, University of Wisconsin, Madison, Wisconsin, USA. Poulsen@bact.wisc.edu.
authors.forename: Michael
authors.initials: M
authors.lastname: Poulsen
mesh_terms: D000818:Animals; D001000:Ants; D005658:Fungi; D010802:Phylogeny; D013559:Symbiosis