Analysis of adiponectin gene polymorphisms in Chinese population with systemic lupus erythematosus.
Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease. Adiponectin is an adipocyte-derived cytokine with anti-inflammatory, antidiabetic, and antiatherogenic properties. No study has reported on the association between adiponectin (ADIPOQ) gene and SLE. Our aim is to investigate the association between single-nucleotide polymorphisms in ADIPOQ gene and SLE. We examined 179 SLE patients and 237 age- and gender-matched controls from Sichuan province in China. Genotypes were determined using polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing. Results show that there was no significant difference in the allele frequencies of rs1501299 (P = .311, OR = 1.17, 95% CI: 0.86-1.59) and rs2241766 (P = .929, OR = 0.99, 95% CI: 0.74-1.33) in ADIPOQ gene between SLE patients and controls. The same results were seen in their genotypes (P < .05). The allele frequencies of rs1501299 and rs2241766 polymorphisms of ADIPOQ may not be associated with SLE risk.
Fang
Wen Liang
WL
Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Zhou
Bin
B
Wang
Yan Yun
YY
Chen
Yu
Y
Zhang
Lin
L
D052242:Adiponectin / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies / Q000379:methods*; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D017720:Molecular Epidemiology; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
D052242:Adiponectin