title: Multistep microwave-assisted divergent synthesis of indolo-fused pyrazino-/diazepinoquinoxalinones on PEG support.
abstract: Synthesis of amino acid and indoline-substituted dinitrobenzene on a soluble polymer support (PEG) and its further reductive double-ring closure to afford structurally diverse indolo-fused pyrazino-/diazepinoquinoxalinones is described. Traceless synthesis of quinoxalinones coupled with application of the Pictet-Spengler-type condensation reaction furnished these novel scaffolds. These hitherto novel heterocycles are synthesized in shorter times under microwave irradiation conditions in comparison with that of classical reaction conditions.
authors.affiliation: Laboratory of Combinatorial Drug Discovery, Department of Applied Chemistry, National Chiao Tung University, Hsinchu, 300-10, Taiwan.
authors.forename: Jin-Ji
authors.initials: JJ
authors.lastname: Lai
authors.forename: Deepak B
authors.initials: DB
authors.lastname: Salunke
authors.forename: Chung-Ming
authors.initials: CM
authors.lastname: Sun
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry*; D011719:Pyrazines / Q000737:chemistry*; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry; D012995:Solubility; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D007211:Indoles; D011719:Pyrazines; D011810:Quinoxalines; D011092:Polyethylene Glycols