Dual role of vitamin C utilization in NO2-induced oxidative stress in lung tissues of mice.
Earlier studies with in vitro models have revealed that application of vitamin C can act as a primary NO(2) absorption substrate to contribute to NO(2)-induced cellular injury. In the present study, we showed that the pharmacological application of vitamin C had dual role in lungs of mice exposed to NO(2), with an exacerbated oxidative stress occurring at low concentrations, as indicated by excessive reactive oxygen species production and lipid peroxidation. However, at high concentrations, vitamin C functioned as an antioxidant removing reactive oxygen species and maintaining a reducing status in cells, alleviating NO(2)-induced oxidative toxicity.
Zhang
Yingyi
Y
College of Life and Chemistry Sciences, Shenyang Normal University, 110034 Shenyang, People's Republic of China.
Ma
Chunyan
C
Xiao
Yuhuan
Y
Liu
Chang
C
Xu
Qiang
Q
Wang
Yan
Y
Xu
Xin
X
Hao
Lin
L
D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism* / Q000494:pharmacology; D001205:Ascorbic Acid / Q000378:metabolism* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D019570:Inhalation Exposure; D008168:Lung / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D009585:Nitrogen Dioxide / Q000633:toxicity*; D018384:Oxidative Stress / Q000187:drug effects*; D017382:Reactive Oxygen Species / Q000378:metabolism
D000393:Air Pollutants; D000975:Antioxidants; D017382:Reactive Oxygen Species; D001205:Ascorbic Acid; D009585:Nitrogen Dioxide