title: The role of long-term doxycycline in patients of idiopathic pulmonaryfibrosis: The results of an open prospective trial.
abstract: OBJECTIVE
  To evaluate the effect of long term use of doxycycline in IPF patients.
  
  
  METHODS
  Patients of IPF, selected randomly from out patient services and diagnosed on the basis of HRCT chest, were put on doxycycline in an open prospective trial. They were followed up with monitoring of subjective well being along with measurement of pulse rate and arterial oxygen saturation at rest and after a fixed and certain exercise, forced vital capacity, six minutes walk test, St Georges Respiratory questionnaire, and serial chest X-rays.
  
  
  RESULTS
  Out of seven patients put on doxycycline, six of them continued the drug for a mean period of 531.43 (+/- 328.88 days). All the patients tolerated the drug well and had shown uniform subjective and overall objective improvement in all the parameters concerned; the change in the radiological parameter being statistically significant.
  
  
  CONCLUSIONS
  Doxycycline merits an appropriate clinical trial in the management of idiopathic pulmonary fibrosis. This widely used and relatively safe drug can add a new dimension to the therapeutic regimen. However, further in-depth studies will be required to evaluate its role in the management of IPF.
authors.affiliation: Institute of Pulmocare and Research, R. G. Kar Medical College and Hospital, Kolkata, India.
authors.forename: Parthasarathi
authors.initials: P
authors.lastname: Bhattacharyya
authors.forename: Saikat
authors.initials: S
authors.lastname: Nag
authors.forename: Sujan
authors.initials: S
authors.lastname: Bardhan
authors.forename: Dipabali
authors.initials: D
authors.lastname: Acharya
authors.forename: Rantu
authors.initials: R
authors.lastname: Paul
authors.forename: Rana
authors.initials: R
authors.lastname: Dey
authors.forename: Malabika
authors.initials: M
authors.lastname: Ghosh
authors.forename: Ratna
authors.initials: R
authors.lastname: Dey
authors.forename: Indranil
authors.initials: I
authors.lastname: Saha