title: Protective effects of vaccines against Bordetella parapertussis in a mouse intranasal challenge model.
abstract: Bordetella parapertussis causes typical whooping cough, as does Bordetella pertussis. However, current commercial vaccines are ineffective against B. parapertussis. In an effort to develop vaccines that are effective in protecting against both B. pertussis and B. parapertussis, we examined the protective effects of vaccines prepared from whole-cells and from recombinant proteins derived from B. parapertussis in a mouse intranasal challenge model. We confirmed current pertussis vaccines did not induce protective immunity against B. parapertussis in the mouse model. A whole-cell vaccine prepared from B. parapertussis induced protective immunity against B. parapertussis but not against B. pertussis, suggesting a combination of a current pertussis vaccine with a whole-cell parapertussis vaccine might prevent whooping cough caused by both species of Bordetella. We also found that filamentous hemagglutinin was a protective antigen of B. parapertussis. Our observations should lead to the development of new pertussis vaccines that can control the two prevalent forms of whooping cough.
authors.affiliation: Research Center for Biologicals, Kitasato Institute, Kitamoto, Saitama Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Komatsu
authors.forename: Fuminori
authors.initials: F
authors.lastname: Yamaguchi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Eguchi
authors.forename: Mineo
authors.initials: M
authors.lastname: Watanabe
mesh_terms: D000372:Agglutination Tests; D000818:Animals; D015153:Blotting, Western; D042483:Bordetella parapertussis / Q000276:immunology* / Q000378:metabolism / Q000502:physiology; D001886:Bordetella pertussis / Q000276:immunology* / Q000378:metabolism / Q000502:physiology; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D010567:Pertussis Vaccine / Q000276:immunology*; D014917:Whooping Cough / Q000276:immunology / Q000517:prevention & control
chemical_list: D010567:Pertussis Vaccine