title: Diversity oriented synthesis of pyrrolidines via natural carbohydrate solid acid catalyst.
abstract: Natural carbohydrate scaffold catalyzed diastereoselective synthesis of functionalized pyrrolidines have been developed via 1,3-dipolar cycloaddition of azomethine ylides derived from alpha-imino esters with dienes or dipolarophiles. Naturally most abundant carbohydrates, like cellulose and starch, were converted into their sulfuric acid derivative, which are exhibiting efficient catalytic properties, along with excellent cost effectivity and recyclability. The advantages of this methodology are diversity oriented metal free synthesis of functionalized pyrrolidines, mild reaction condition, high diasteroselectivity and yield.
authors.affiliation: Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, India. dratulsax@gmail.com
authors.forename: Atul
authors.initials: A
authors.lastname: Kumar
authors.forename: Garima
authors.initials: G
authors.lastname: Gupta
authors.forename: Suman
authors.initials: S
authors.lastname: Srivastava
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D008968:Molecular Conformation; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002241:Carbohydrates; D011759:Pyrrolidines