title: Association between albuminuria, carotid atherosclerosis, arterial stiffness, and peripheral arterial disease in Korean type 2 diabetic patients.
abstract: BACKGROUND
  To evaluate the association between albuminuria, carotid atherosclerosis, arterial stiffness, and peripheral arterial disease (PAD) in Korean type 2 diabetic patients.
  
  
  METHODS
  In total, 673 type 2 diabetic patients registered with the public health center participated. Following an overnight fast, venous blood and urine samples were collected and analyzed. The carotid intima-media thickness (IMT), amount of carotid plaque, brachial ankle pulse wave velocity (baPWV), and the ankle-brachial index of each patient were also assessed.
  
  
  RESULTS
  Albuminuria was significantly associated with PAD (odds ratio (OR) 2.33; 95% confidence interval (CI) 1.28-4.25 for normoalbuminuria vs. microalbuminuria and OR 3.28; 95% CI 1.40-7.66 for normoalbuminuria vs. macroalbuminuria), but not with carotid plaque. The mean baPWV differed significantly according to the level of albumin relative to the creatinine ratio (1,764.79, 1,778.98, and 2,001.33, respectively; p < 0.001), while no significant difference was observed in the mean IMT value (0.73, 0.74, and 0.72, respectively; p = 0.399).
  
  
  CONCLUSIONS
  Albuminuria was significantly associated with baPWV and PAD, but not with carotid plaque or CCA-IMT, in Korean type 2 diabetic patients.
authors.affiliation: Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
authors.forename: Seong-Woo
authors.initials: SW
authors.lastname: Choi
authors.forename: Woo-Jun
authors.initials: WJ
authors.lastname: Yun
authors.forename: Hey-Yeon
authors.initials: HY
authors.lastname: Kim
authors.forename: Young-Hoon
authors.initials: YH
authors.lastname: Lee
authors.forename: Sun-Seog
authors.initials: SS
authors.lastname: Kweon
authors.forename: Jung-Ae
authors.initials: JA
authors.lastname: Rhee
authors.forename: Jin-Su
authors.initials: JS
authors.lastname: Choi
authors.forename: Min-Ho
authors.initials: MH
authors.lastname: Shin
mesh_terms: D000368:Aged; D000419:Albuminuria / Q000150:complications* / Q000503:physiopathology*; D001158:Arteries / Q000503:physiopathology; D002340:Carotid Artery Diseases / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000209:etiology; D014655:Vascular Resistance