Affinity measured by microcluster.
Like T cell activation, B cell activation is driven by aggregation of B cell receptors (BCRs) into microclusters. New work suggests that the early dynamics of BCR mobility and microcluster formation "translate" BCR affinity for antigen into B cell responsiveness.
Fooksman
David R
DR
Martin and Helen Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA.
Dustin
Michael L
ML
D000199:Actins / Q000276:immunology; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D003598:Cytoskeletal Proteins / Q000276:immunology; D005818:Genetic Engineering; D054992:Immunological Synapses / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D051379:Mice; D018448:Models, Immunological; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D000099149:Ezrin
D000199:Actins; D003598:Cytoskeletal Proteins; D011947:Receptors, Antigen, B-Cell; D000099149:Ezrin