The JARID2-PRC2 duality.
Polycomb group proteins (PcG) are required for proper developmental regulation and cell fate commitment in metazoans. Recently, four studies reported the identification of JARID2, a JmjC domain-containing protein, as a component of the Polycomb-repressive complex 2 (PRC2), which is involved in implementing histone H3 Lys 27 methylation and transcriptional repression during development. Here, we discuss the implications of these studies for an improved understanding of PcG function in development.
Herz
Hans-Martin
HM
Stowers Institute for Medical Research, Kansas City, Missouri 64110, USA.
Shilatifard
Ali
A
D000818:Animals; D029721:Drosophila Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D020868:Gene Silencing; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism*; D006801:Humans; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism*
D029721:Drosophila Proteins; D009419:Nerve Tissue Proteins; D011495:Histone-Lysine N-Methyltransferase; C524066:PRC2 protein, Drosophila