Diagnostic and therapeutic potentials of platelet glycoprotein VI.
Platelets respond immediately to vascular injury by adhesion, aggregation, and thrombus formation. Disruption of the endothelial cell layer exposes extracellular matrix to the bloodstream. Collagen binding to platelet glycoprotein VI (GPVI) mediates the initial adhesion of the rolling platelet to the vascular wound. Signaling by GPVI leads to the onset of the platelet activation cascade that is finally crowned by a firm and shear-resistant integrin-based adhesive clot. Blockade of collagen binding to GPVI would prevent initial adhesion and further activation of the platelet and would have an enormous impact in antithrombotic therapy. Besides the therapeutical implication, radiolabeled GPVI gives us a valuable diagnostic means that may be used clinically for plaque imaging in the near future.
Bigalke
Boris
B
Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard-Karls-Universität Tübingen, Germany. boris.bigalke@med.uni-tuebingen.de
Krämer
Björn F
BF
Seizer
Peter
P
Fateh-Moghadam
Suzanne
S
Gawaz
Meinrad
M
Lindemann
Stephan
S
D050197:Atherosclerosis / Q000175:diagnosis / Q000188:drug therapy; D003094:Collagen / Q000378:metabolism; D005343:Fibrinolytic Agents / Q000494:pharmacology; D006801:Humans; D015539:Platelet Activation / Q000187:drug effects; D010980:Platelet Membrane Glycoproteins / Q000032:analysis* / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D012995:Solubility
D005343:Fibrinolytic Agents; D010980:Platelet Membrane Glycoproteins; C098341:platelet membrane glycoprotein VI; D003094:Collagen