[Expression and significance of IGF-IR and PKC in laryngeal squamous cell carcinoma].
OBJECTIVE
To investigate the expression of IGF-IR and PKC and their clinical significance in laryngeal squamous cell carcinoma(LSCC).


METHODS
The expression of IGF-IR and PKC protein were detected by immunohistochemistry and Western blot in 60 cases of LSCC, 25 cases of adjacent non-tumorous laryngeal epithelium and 10 cases of normal laryngeal epithelium.


RESULTS
The positive rate of IGF-IR and PKC expression in LSCC were significantly higher than that in normal laryngeal epithelium and adjacent non-tumorous laryngeal epithelium (P < 0.05). IGF-IR positive expression were increased more in cases with stage III-IV, cervical lymph node metastasis and well differentiation than that in cases with stage I-II, non-lymph node metastasis and poor/mediate differentiation, respectively (P < 0.05). The positive rate of PKC in LSCC were correlated with clinical stage and cervical lymph node metastasis. There was a correlation between the expression of IGF-IR and PKC in LSCC.


CONCLUSIONS
The overexpression of IGF-IR and PKC in the laryngeal carcinoma may play an important role in the carcinogenesis and development of LSCC. It is suggested that detecting the expression of IGF-IR and PKC can be used for early diagnosis and treatment of LSCC.
Liu
Jie
J
Department of Otolaryngology-Head and Neck Surgery,Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
Pan
Song
S
Zhou
Yuanhong
Y
Yu
Zhihua
Z
Liu
Lisi
L
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011493:Protein Kinase C / Q000378:metabolism*; D017526:Receptor, IGF Type 1 / Q000378:metabolism*
D017526:Receptor, IGF Type 1; D011493:Protein Kinase C