Investigation of serotonin transporter gene promoter (5-HTTLPR) and intron 2 (variable number of tandem repeats) polymorphisms with suicidal behavior in a Turkish population.
The serotonin (5-hydroxytryptamine) transporter (5HTt) gene has been reported to be associated with suicidal behavior. In this study, we have investigated the 5' promoter region (i.e., 5HTt gene-linked polymorphic region [5-HTTLPR]) and a 17-base pair variable number of tandem repeats polymorphism in the 5HTt gene for potential association with suicidal behavior in a Turkish population. Genotypes were determined for 182 subjects of suicide (86 attempted suicide and 96 completed suicide) and 181 healthy control subjects. Our results showed that allele frequencies at individual loci were not significantly different in the two groups. This absence of altered individual locus haplotype (allele) frequency suggests the lack of a significant genetic contribution by the 5-HTTLPR or variable number of tandem repeats variations to the expression of suicidal tendencies. However, our linkage disequilibrium analyses indicated that there may be a greater risk for suicidal behavior in carriers of the S10 and L12 alleles of 5-HTTLPR.
Akar
Taner
T
Department of Forensic Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey. tanerakar@yahoo.com
Sayin
Aslihan
A
Bakkaloğlu
Zekiye
Z
Cabuk
Duygu Kaya
DK
Küçükyildirim
Sibel
S
Demirel
Birol
B
Candansayar
Selçuk
S
Ozsoy
Ergi Deniz
ED
Mergen
Hatice
H
D000328:Adult; D005260:Female; D006801:Humans; D007438:Introns; D008297:Male; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013405:Suicide; D020080:Tandem Repeat Sequences; D014421:Turkey
C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins