Relevance of GERD in lung transplant patients.
Lung transplantation has become a valuable treatment for end-stage pulmonary disorders in an attempt to improve quality of life and extend survival. Development of chronic rejection, also known as bronchiolitis obliterans syndrome (BOS), is responsible for the vast majority of deaths after lung transplantation. Up to 50% of lung transplant patients develop BOS within the first 5 years after transplantation. A high prevalence of gastroesophageal reflux and aspiration of gastric components has been described after lung transplantation. Reflux and aspiration have been implicated in the development of BOS and antireflux surgery has been proposed; however, the causal relationship with BOS and the impact of reflux in lung transplantation survival needs to be further elucidated.
Mertens
Veerle
V
Center for Gastroenterological Research, KU Leuven, Leuven, Belgium.
Dupont
Lieven
L
Sifrim
Daniel
D
D001989:Bronchiolitis Obliterans / Q000209:etiology*; D005764:Gastroesophageal Reflux / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects* / Q000401:mortality; D053120:Respiratory Aspiration / Q000150:complications* / Q000453:epidemiology / Q000628:therapy; D015996:Survival Rate; D013577:Syndrome