A new phenylpropane glycoside from the rhizome of Sparganium stoloniferum.
The purification of the MeOH extract from the rhizome of Sparganium stoloniferum Buch.-Hamil. (Sparganiaceae) using column chromatography furnished one new phenylpropanoid glycoside (7) and known phenolic compounds (1-6, and 8-13). The structural elucidation of 7 was based on 1D- and 2D-NMR spectroscopic data analysis to be beta-D-(6-O-trans-feruloyl) fructofuranosyl-alpha-D-O-glucopyranoside. Compounds 1-6, and 8-13 were elucidated by spectroscopy and confirmed by comparison with reported data; 24-methylenecycloartanol (1), p-hydroxybenzaldehyde (2), ferulic acid (3), p-coumaric acid (4), vanillic acid (5), beta-D-(1-O-acetyl-3-O-trans-feruloyl)fructofuranosy-alpha-D-2',4',6'.-O-triacetyglucopyranoisde (6), beta-D-(1-O-acetyl-3,6-O-trans-diferuloyl)fructofuranosyl-beta-D-2',4',6'.-O-triacetylglucopyranoisde (8), hydroxytyrosol acetate (9), hydroxytyrosol (10), isorhamnetin-3-O-rutinoside (11), n-butyl-alpha-D-fructofuranoside (12), and n-butyl-beta-D-fructopyranoside (13). Compounds 3 and 9-13 were isolated for the first time from this plant. The isolated compounds were tested for cytotoxicity against four human tumor cell lines in vitro using a Sulforhodamin B bioassay.
Lee
Seung Young
SY
Natural Products Laboratory, School of Pharmacy, Sungkyunkwan University, Suwon, 440-746, Korea.
Choi
Sang Un
SU
Lee
Jei Hyun
JH
Lee
Dong Ung
DU
Lee
Kang Ro
KR
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006027:Glycosides / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010666:Phenylpropionates / Q000302:isolation & purification* / Q000494:pharmacology; D027343:Rhizome / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D032401:Typhaceae / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D010666:Phenylpropionates