title: Leptomeningeal carcinomatosis from renal cell cancer: treatment attempt with radiation and sunitinib (case report).
abstract: A case of leptomeningeal carcinomatosis in a patient with known brain and lung metastases from renal cell cancer without previous systemic therapy is presented. Neoplastic meningitis (NM) developed 31 months after first diagnosis of simultaneous extra- and intracranial recurrence of kidney cancer and surgical resection of a cerebellar metastasis. In spite of local radiotherapy to the macroscopic NM lesions in the cervical and lumbar spine followed by initiation of sunitinib, the patient succumbed to his disease 4 months after the diagnosis of NM. The untreated lung metastases progressed very slowly during almost 3 years of observation. This case illustrates important issues around both biological behaviour and treatment approaches in metastatic renal cell cancer.
authors.affiliation: Department of Oncology and Palliative Medicine, Nordland Hospital, Bodø, Norway. astrid.dalhaug@nlsh.no
authors.forename: Astrid
authors.initials: A
authors.lastname: Dalhaug
authors.forename: Ellinor
authors.initials: E
authors.lastname: Haukland
authors.forename: Carsten
authors.initials: C
authors.lastname: Nieder
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000556:secondary* / Q000601:surgery; D002292:Carcinoma, Renal Cell / Q000556:secondary* / Q000601:surgery; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery; D008175:Lung Neoplasms / Q000556:secondary* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D055756:Meningeal Carcinomatosis / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary* / Q000628:therapy*; D011758:Pyrroles / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D000077210:Sunitinib; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D000077210:Sunitinib