Antimicrobial coumarins from the stem bark of Afraegle paniculata.
Eight compounds were isolated from the stem bark of the plant Afraegle paniculata. One of them, a dimethyl ether of S-trans-marmin (1), is reported as a new natural product. The structures were determined by comprehensive analyses of their 1D and 2D NMR spectroscopic and HREIMS data. The remaining seven known compounds, identified by comparing their spectroscopic data with those reported in the literature, were S-trans-marmin (2), psoralene (3), bergaptene (4), imperatorin (5), 2-(4-hydroxy-3,5-dimethoxyphenyl)-3-hydroxymethyl-2,3-dihydro- 1,4,5-trioxaphenanthren-6-one (6), xanthoxyletin (7), and beta-sitosterol glucopyranoside. Preliminary studies indicated that compounds 2, 3, 5, and 7 showed potent antibacterial, fungicidal, and algicidal properties, while 6 showed only moderate algicidal property.
Tsassi
Valerie Beatrice
VB
Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
Hussain
Hidayat
H
Meffo
Bouberte Yemele
BY
Kouam
Simeon F
SF
Dongo
Etienne
E
Schulz
Barbara
B
Greene
Ivan R
IR
Krohn
Karsten
K
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003374:Coumarins