title: Conformationally constrained spiro C-arylglucosides as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
authors.affiliation: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, No 16, Southion 2, The First Circle Road, 610041 Chengdu, PR China.
authors.forename: Binhua
authors.initials: B
authors.lastname: Lv
authors.forename: Yan
authors.initials: Y
authors.lastname: Feng
authors.forename: Jiajia
authors.initials: J
authors.lastname: Dong
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.forename: Baihua
authors.initials: B
authors.lastname: Xu
authors.forename: Wenbin
authors.initials: W
authors.lastname: Zhang
authors.forename: Zelin
authors.initials: Z
authors.lastname: Sheng
authors.forename: Ajith
authors.initials: A
authors.lastname: Welihinda
authors.forename: Brian
authors.initials: B
authors.lastname: Seed
authors.forename: Yuanwei
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy; D005960:Glucosides / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D006801:Humans; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D051269:Sodium-Glucose Transporter 1 / Q000037:antagonists & inhibitors / Q000378:metabolism; D051297:Sodium-Glucose Transporter 2 / Q000378:metabolism; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D013141:Spiro Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D005960:Glucosides; D007004:Hypoglycemic Agents; D051269:Sodium-Glucose Transporter 1; D051297:Sodium-Glucose Transporter 2; D000077203:Sodium-Glucose Transporter 2 Inhibitors; D013141:Spiro Compounds