Breaching multiple barriers: leukocyte motility through venular walls and the interstitium.
The shuttling of leukocytes between the bloodstream and interstitial tissues involves different locomotion strategies that are governed by locally presented soluble and cell-bound signals. Recent studies have furthered our understanding of the rapidly advancing field of leukocyte migration, particularly regarding cellular and subcellular events at the level of the venular wall. Furthermore, emerging cellular models are now addressing the transition from an adherent mode to a non-adherent state, incorporating mechanisms that support an efficient migratory profile of leukocytes in the interstitial tissue beyond the venular wall.
Nourshargh
Sussan
S
Barts and The London School of Medicine and Dentistry, Queen Mary University of London, William Harvey Research Institute, Charterhouse Square, London, UK. s.nourshargh@qmul.ac.uk
Hordijk
Peter L
PL
Sixt
Michael
M
D000818:Animals; D001485:Basement Membrane / Q000166:cytology / Q000378:metabolism; D002465:Cell Movement; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000166:cytology* / Q000378:metabolism; D020286:Pericytes / Q000166:cytology / Q000378:metabolism; D014699:Venules / Q000166:cytology* / Q000378:metabolism