Primary mediastinal liposarcoma, with 6 years of follow-up to autopsy, revealed histopathological features of primary and metastatic lesions.
Primary mediastinal liposarcoma was observed in a 73-year-old man. Because of tight adhesions to adjacent tissues, neither complete resection nor surgical debulking of the tumor was possible. A T-tube was inserted into the patient's trachea for severe dyspnea, and he was treated with radiotherapy and an oral peroxisome proliferator-activated receptor-gamma agonist. The patient died 6 years after the initial diagnosis. Autopsy revealed liposarcoma composed of 3 subtypes in the primary tumor: well-differentiated, dedifferentiated, and round cell components. Round cell and dedifferentiated liposarcomas were predominantly observed in the metastatic nodules.
Konno
Satoshi
S
The First Department of Medicine, Hokkaido University School of Medicine, Sapporo. satkonno@med.hokudai.ac.jp
Oizumi
Satoshi
S
Shinagawa
Naofumi
N
Kikuchi
Eiki
E
Konishi
Jun
J
Ito
Kenichiro
K
Hizawa
Nobuyuki
N
Takiyama
Akihiro
A
Tanaka
Shinya
S
Nishimura
Masaharu
M
D000368:Aged; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006801:Humans; D008080:Liposarcoma / Q000473:pathology* / Q000532:radiotherapy / Q000556:secondary*; D008297:Male; D008479:Mediastinal Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000556:secondary*