The role of azithromycin in patients with cystic fibrosis.
Interest in azithromycin in the management of patients with cystic fibrosis has grown over the last decade. Uniquely this drug has both antibacterial and immune modulating effects which appear to be the reason for its clinical benefit as proven in several well designed clinical studies. In this review we discuss the proposed mechanisms of action of azithromycin and review the evidence for its clinical effectiveness and safety in cystic fibrosis.
Yousef
Abdullah A
AA
Department of Respiratory Medicine, Sydney Children's Hospital, High Street, Randwick 2031, University of New South Wales, Randwick, Sydney, Australia. Abdullah.Yousef@SESIAHS.HEALTH.NSW.GOV.AU
Jaffe
Adam
A
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017963:Azithromycin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003550:Cystic Fibrosis / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology* / Q000503:physiopathology; D006801:Humans
D000900:Anti-Bacterial Agents; D017963:Azithromycin