title: Naturally occurring infections in non-human primates (NHP) and immunotoxicity implications: discussion sessions.
abstract: Non-human primates (NHP) are used to best understand and address pharmacology and toxicology obligations for human patients with highest and/or unmet need. In order to ensure the most appropriate care and use of NHP, it is important to understand the normal micro flora and fauna of NHP and ensure their utmost health to generate the most valuable and applicable data. There are many infections, including viral, bacterial, parasitic, and fungal that may perturb physiologic endpoints relevant to human health, and are essential to monitor and/or eradicate for NHP health. This publication captures a discussion involving the experience, knowledge and opinion from academic, industry and government experts regarding emerging and normal infections in NHP as they relate to immunotoxicity, and treatment and consequences of known infections.
authors.affiliation: Merrimack Pharmaceuticals, Cambridge, MA, USA. kolivier@merrimackpharma.com
authors.forename: Kenneth J
authors.initials: KJ
authors.lastname: Olivier
authors.forename: Karen D
authors.initials: KD
authors.lastname: Price
authors.forename: David L
authors.initials: DL
authors.lastname: Hutto
authors.forename: Nicholas W
authors.initials: NW
authors.lastname: Lerche
authors.forename: Keith G
authors.initials: KG
authors.lastname: Mansfield
authors.forename: Joe H
authors.initials: JH
authors.lastname: Simmons
authors.forename: Katrina
authors.initials: K
authors.lastname: Taylor
authors.forename: L Peyton
authors.initials: LP
authors.lastname: Myers
authors.forename: Yanli
authors.initials: Y
authors.lastname: Ouyang
authors.forename: Ellen W
authors.initials: EW
authors.lastname: Evans
mesh_terms: D000818:Animals; D003140:Communicable Disease Control; D003141:Communicable Diseases / Q000382:microbiology*; D004353:Drug Evaluation, Preclinical; D007107:Immune System / Q000187:drug effects*; D007165:Immunosuppression Therapy; D023421:Models, Animal; D008992:Monkey Diseases / Q000382:microbiology* / Q000517:prevention & control; D009894:Opportunistic Infections / Q000382:microbiology* / Q000517:prevention & control; D018675:Toxicity Tests; D014730:Veterinary Medicine; D015262:Xenobiotics / Q000633:toxicity*
chemical_list: D015262:Xenobiotics