title: The changing face of Parkinson's disease-associated psychosis: a cross-sectional study based on the new NINDS-NIMH criteria.
abstract: New criteria for Parkinson's disease-associated psychosis (PDAP) were recently proposed by a NINDS-NIMH working group. We assessed 116 consecutive unselected outpatients with PD for the existence of psychotic symptoms during the previous month, using a structured questionnaire covering the whole spectrum of PDAP symptoms. Hallucinations occurred in 42% of the patients (visual: 16%; nonvisual: 35%), delusions in 4%, and minor symptoms in 45% (sense of presence, visual illusions, or passage hallucinations). The prevalence of PDAP was 43% when the usual definition was used (hallucinations and/or delusions) and 60% when the NINDS-NIHM criteria were used. Correlations between PDAP and patient characteristics varied with the definition of PDAP. These findings suggest that the epidemiology of PDAP should be re-evaluated with the new criteria. Minor symptoms and nonvisual hallucinations are an important part of the PDAP spectrum, which has commonly been restricted to visual hallucinations and delusions.
authors.affiliation: AP-HP, Department of Neurology, CHU Henri Mondor, Créteil, France. gilles.fenelon@hmn.aphp.fr
authors.forename: Gilles
authors.initials: G
authors.lastname: Fénelon
authors.forename: Thierry
authors.initials: T
authors.lastname: Soulas
authors.forename: Franck
authors.initials: F
authors.lastname: Zenasni
authors.forename: Laurent
authors.initials: L
authors.lastname: Cleret de Langavant
mesh_terms: D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009315:National Institute of Mental Health (U.S.) / Q000592:standards*; D055825:National Institute of Neurological Disorders and Stroke (U.S.) / Q000592:standards*; D010300:Parkinson Disease / Q000150:complications / Q000175:diagnosis*; D011618:Psychotic Disorders / Q000150:complications / Q000175:diagnosis*; D012016:Reference Values; D014481:United States