title: [Prosthetic joint infections by multi-drug resistant bacteria].
abstract: Prosthetic joint infections by multi-drug resistant bacteria are today one of the most important and complex problems in orthopedics and traumatology. Most important and frequent resistant bacteria involved in infection of total joint replacements include: methicillin-resistant Staphylococcus aureus, methicillin-resistant coagulase-negative staphylococci, vancomycin-resistant enterococci, multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii. There are several laboratory tests available, but none has been shown to achieve 100% of sensitivity and specificity. Treatment of a patient with infection by a resistant organism, requires costly and prolonged hospital stay, weeks or months of antibiotic therapy, and often multiple surgical procedures. Only a strictly cooperation between orthopedic surgeon and infectious disease specialist, before, during and after prosthetic joint procedure, could improve patient management.
authors.affiliation: D.A.I. Malattie Infettive e Medicina Interna, Seconda Università degli Studi di Napoli, Napoli, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: Bulla
authors.forename: Pietro
authors.initials: P
authors.lastname: Filippini
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D001170:Arthritis, Infectious / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology / Q000382:microbiology* / Q000601:surgery; D001431:Bacteriological Techniques; D019090:Case Management; D003131:Combined Modality Therapy; D024901:Drug Resistance, Multiple, Bacterial; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification; D016905:Gram-Negative Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000601:surgery; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000601:surgery; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008826:Microbial Sensitivity Tests; D016459:Prosthesis-Related Infections / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology* / Q000601:surgery; D013530:Surgical Wound Infection / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents