title: Safety and efficacy of combined transrectal ultrasound-guided prostate needle biopsy and transurethral resection of the prostate.
abstract: OBJECTIVE
  This study was conducted to examine whether simultaneous transrectal prostate needle biopsy (TPNB) owing to an increase in prostate-specific antigen (PSA) levels is safe and effective in patients who are scheduled for transurethral resection of the prostate (TURP) for benign prostatic hyperplasia (BPH).
  
  
  METHODS
  Combined TPNB and TURP was performed in a total of 42 patients aged 60 years and older who had gray-zone PSA values (4-10 ng/ml) and PSA density (PSAD) values of 0.12 and less. The frequencies of fever, sepsis, and epididymitis were assessed after surgery. The diagnostic accuracy was assessed, and the results of histologic examination were evaluated in terms of TPNB or TURP. In addition, the diagnostic accuracy was assessed according to age.
  
  
  RESULTS
  Prostate cancer was diagnosed in 6 (14.3%) of the 42 patients: 2 patients were diagnosed with prostate cancer by TPNB only, 3 patients by TURP only, and 1 patient by combined TPNB and TURP. Four (25%) of the 16 patients aged under 70 years and 2 (7.8%) of the 26 patients aged 70 years and older were diagnosed with prostate cancer. Fever was observed in 9 patients (21.4%), 4 (9.5%) of whom had a fever of higher than 38. The fever normalized the day after surgery in all 9 patients. No septicemia was noted. There were no serious complications related to combined TPNB and TURP.
  
  
  CONCLUSIONS
  The results of this study suggest that combined TPNB and TURP may be safe and effective in patients who require TURP.
authors.affiliation: Department of Urology, Eulji University School of Medicine, Seoul, Korea.
authors.forename: Jeong Man
authors.initials: JM
authors.lastname: Cho
authors.forename: Seung Wook
authors.initials: SW
authors.lastname: Lee
authors.forename: Jung Yoon
authors.initials: JY
authors.lastname: Kang
authors.forename: Tag Keun
authors.initials: TK
authors.lastname: Yoo