title: Specialized refeeding treatment for anorexia nervosa patients suffering from extreme undernutrition.
abstract: OBJECTIVE
  Refeeding severely malnourished patients with Anorexia nervosa requires specialized in-patient treatment to reduce medical risks, to avoid refeeding syndrome and other life-threatening situations.
  
  
  METHODS
  The authors present a retrospective cohort nutritional rehabilitation study of 33 very severe Anorexia nervosa in-patients, aged 22.8 ± 7.6 years (mean ± SD) and with an initial body mass index ≤ 12 kg/m(2), treated in a specialized Eating Disorders Unit.
  
  
  RESULTS
  Thirty-three female patients were included and treated. Mean BMI increased from 11.3 ± 0.7 Kg/m(2), to 13.5 ± 1 Kg/m(2), and mean body weight from 29.1 ± 3.2 Kg to 34.5 ± 3.3 Kg, after 60 days of intensive in-patient treatments (p < 0.0001). Feeding was carefully instituted; caloric intake levels were established after measuring REE by indirect calorimetry. Nutritional support was initiated with temporary nasogastric feeding in 30 patients, and with oral supplementation in 3 patients. Vitamins, potassium and phosphate supplements were administered during refeeding. All patients achieved a significant increase in body weight, none developed refeeding syndrome as far as laboratory and clinical investigations were concerned.
  
  
  CONCLUSIONS
  Our findings show that, even in cases of extreme undernutrition, if feeding is performed cautiously and in a specialized unit, it is possible to avoid the refeeding syndrome.
authors.affiliation: Eating Disorders Unit, Niguarda Hospital, Piazza Ospedale Maggiore 3, 20126 Milan, Italy. centrodca@ospedaleniguarda.it
authors.forename: Maria Gabriella
authors.initials: MG
authors.lastname: Gentile
authors.forename: Paola
authors.initials: P
authors.lastname: Pastorelli
authors.forename: Raffaella
authors.initials: R
authors.lastname: Ciceri
authors.forename: Giulia Maria
authors.initials: GM
authors.lastname: Manna
authors.forename: Simona
authors.initials: S
authors.lastname: Collimedaglia
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000178:diet therapy*; D000886:Anthropometry; D001823:Body Composition; D015992:Body Mass Index; D002153:Calorimetry, Indirect; D015331:Cohort Studies; D002149:Energy Intake; D005260:Female; D006801:Humans; D018529:Nutritional Support; D055677:Refeeding Syndrome / Q000517:prevention & control*; D012189:Retrospective Studies; D055815:Young Adult