title: Low risk of symptomatic venous thromboembolic events during growth factor administration for PBSC mobilization.
abstract: The use of erythropoietic agents has been associated with an increased risk of venous thromboembolic events (VTEs), especially in patients with underlying malignancies. However, it is not known whether there is an increased risk of VTE associated with granulocyte growth factors. We reviewed 621 patients undergoing PBSC mobilization using granulocyte growth factors, alone or in combination with CY. Patients with a diagnosis of AL amyloidosis (AL: 114; 18%), multiple myeloma (MM: 278; 44%) Hodgkin lymphoma (HL: 20; 3%) or non-Hodgkin lymphoma (NHL: 209; 33%) were included. Symptomatic VTE occurred in six (0.97%) patients: two AL, two MM and two NHL. Of the six patients, two had pulmonary embolism, one developed deep vein thrombosis and three developed symptomatic catheter related thrombosis. Two patients with AL had heparin-induced thrombocytopenia and thrombosis. We found a low incidence of VTE among patients undergoing PBSC mobilization.
authors.affiliation: Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN 55906, USA.
authors.forename: H V
authors.initials: HV
authors.lastname: Naina
authors.forename: R K
authors.initials: RK
authors.lastname: Pruthi
authors.forename: D J
authors.initials: DJ
authors.lastname: Inwards
authors.forename: D
authors.initials: D
authors.lastname: Dingli
authors.forename: M R
authors.initials: MR
authors.lastname: Litzow
authors.forename: S M
authors.initials: SM
authors.lastname: Ansell
authors.forename: H J
authors.initials: HJ
authors.lastname: William
authors.forename: A
authors.initials: A
authors.lastname: Dispenzieri
authors.forename: F K
authors.initials: FK
authors.lastname: Buadi
authors.forename: M A
authors.initials: MA
authors.lastname: Elliott
authors.forename: D A
authors.initials: DA
authors.lastname: Gastineau
authors.forename: M A
authors.initials: MA
authors.lastname: Gertz
authors.forename: S R
authors.initials: SR
authors.lastname: Hayman
authors.forename: P B
authors.initials: PB
authors.lastname: Johnston
authors.forename: M Q
authors.initials: MQ
authors.lastname: Lacy
authors.forename: I N
authors.initials: IN
authors.lastname: Micallef
authors.forename: L F
authors.initials: LF
authors.lastname: Porrata
authors.forename: S
authors.initials: S
authors.lastname: Kumar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D008297:Male; D008875:Middle Aged; D012306:Risk; D054556:Venous Thromboembolism / Q000209:etiology*
chemical_list: D016179:Granulocyte Colony-Stimulating Factor