Access to original vinylic chlorides in the quinazoline series via a monoelectronic transfer reaction approach.
A series of new quinazoline derivatives bearing a vinylic chloride group on the 2-position was prepared by using a consecutive S(RN)1 / E(RC)1 radical strategy.
Maillard-Boyer
Martine
M
Laboratoire de Pharmacochimie Radicalaire, Faculté de Pharmacie, Universités d'Aix-Marseille I, II et III - UMR CNRS 6264, Laboratoire Chimie Provence, 27 Boulevard Jean Moulin, Marseille cedex 05, France. martine.maillard@univmed.fr
Castera-Ducros
Caroline
C
Verhaeghe
Pierre
P
Sifredi
France
F
Rathelot
Pascal
P
Vanelle
Patrice
P
D000962:Antimalarials / Q000138:chemical synthesis / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry*; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry*; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry*; D014752:Vinyl Chloride / Q000737:chemistry*
D000962:Antimalarials; D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D014752:Vinyl Chloride