title: MRI findings of rapidly progressive hepatocellular carcinoma.
abstract: OBJECTIVE
  The purpose of this study is to determine the magnetic resonance imaging (MRI) and patient characteristics in subjects with hepatocellular carcinoma (HCC) that exhibit rapid progression.
  
  
  METHODS
  In this unblinded retrospective study, initial and follow up MR images were reviewed, before and after rapid progression of HCC, respectively. Rapid progression was defined as a lesion <3 cm which exhibited >3 cm increase in one year or 2 cm increase in 6 months. Patient characteristics and MRI findings were determined using clinical information from the institution clinical information system and records from the Radiology and Pathology Departments, Hepatology Division and Liver Transplant Service of the Department of Medicine.
  
  
  RESULTS
  Seven individuals were identified with HCC that showed rapid progression. Five of the patients had underlying hepatitis C, one had alcoholic hepatitis, and one had immunosuppression due to liver transplantation. On initial MRI, six patients had early intense ring enhancing lesions, which rapidly progressed in size. Five patients died within 6 months, one within 1 year after progression despite treatment. Six of the seven patients also had multiple other liver nodules on initial MRI; those that showed ring enhancement rapidly progressed but those without, did not show rapid progression.
  
  
  CONCLUSIONS
  Patients with rapidly progressive HCC had underlying hepatitis C and intense ring enhancement on initial MRI. This group of patients should be evaluated further to determine if they might benefit from early intervention.
authors.affiliation: Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7510, USA.
authors.forename: Andrea S
authors.initials: AS
authors.lastname: Kierans
authors.forename: Polytimi
authors.initials: P
authors.lastname: Leonardou
authors.forename: Paul
authors.initials: P
authors.lastname: Hayashi
authors.forename: Lauren M
authors.initials: LM
authors.lastname: Brubaker
authors.forename: Mohamed
authors.initials: M
authors.lastname: Elazzazi
authors.forename: Faiq
authors.initials: F
authors.lastname: Shaikh
authors.forename: Richard C
authors.initials: RC
authors.lastname: Semelka
mesh_terms: D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D003287:Contrast Media; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D019786:Gadolinium DTPA; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives; D008875:Middle Aged; D009942:Organometallic Compounds; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine; C064925:gadodiamide; D019786:Gadolinium DTPA