title: Absolute stereochemistry of pentacecilides, new inhibitors of lipid droplet formation in mouse macrophages, produced by Penicillium cecidicola FKI-3765-1.
abstract: The structure of a new pentacecilide congener, pentacecilide D, produced by Penicillium cecidicola FKI-3765-1 was elucidated by various NMR experiments. The absolute stereochemistry of pentacecilides was elucidated by using the modified Mosher method for pentacecilide C. The inhibitory activity of all pentacecilides against lipid droplet formation and acyl-CoA:cholesterol acyltransferase isozymes was compared.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kitasato University, Minato-ku, Tokyo, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Narihiro
authors.initials: N
authors.lastname: Ugaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Matsuda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tomoda
mesh_terms: D000818:Animals; D016466:CHO Cells / Q000187:drug effects; D002788:Cholesterol Esters / Q000096:biosynthesis; D006224:Cricetinae; D003412:Cricetulus; D000960:Hypolipidemic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D050356:Lipid Metabolism / Q000187:drug effects*; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D019906:Nuclear Magnetic Resonance, Biomolecular; D010407:Penicillium / Q000378:metabolism*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D002788:Cholesterol Esters; D000960:Hypolipidemic Agents; D012717:Sesquiterpenes; C544291:pentacecilide A; C544292:pentacecilide B; C544290:pentacecilide C; C550747:pentacecilide D