In situ formation of thermosensitive PNIPAAm-based hydrogels by Michael-type addition reaction.
To investigate the possibility of in situ thermosensitive hydrogel formation via Michael-type addition reaction, we designed and prepared thiol- and vinyl-modified poly(N-isopropylacrylamide) (PNIPAAm)-based copolymers. When the solutions of these two kinds of PNIPAAm-based copolymers were mixed at physiological temperature (37 degrees C), a physical gelation resulting from the hydrophobic aggregation of PNIPAAm based copolymers and chemical cross-linking between thiol and vinyl functional groups or so-called chemical gelation occurred, resulting in the formation of a three-dimensional hydrogel. Because all the gelations were performed at a high temperature (above LCSTs of the PNIPAAm based copolymers), these in situ formed hydrogels presented heterogeneous network structures, resulting in an improved thermosensitivity in comparison with the conventional one.
Wang
Zong-Chun
ZC
Department of Chemistry, Wuhan University, Wuhan 430072, People's Republic of China.
Xu
Xiao-Ding
XD
Chen
Chang-Sheng
CS
Yun
Liu
L
Song
Jin-Chun
JC
Zhang
Xian-Zheng
XZ
Zhuo
Ren-Xi
RX
D000178:Acrylamides / Q000737:chemistry*; D000180:Acrylic Resins; D001672:Biocompatible Materials / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D006358:Hot Temperature; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008422:Materials Testing; D008956:Models, Chemical; D009991:Oscillometry / Q000379:methods; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties; D013696:Temperature
D000178:Acrylamides; D000180:Acrylic Resins; D001672:Biocompatible Materials; D020100:Hydrogels; D011108:Polymers; C052970:poly-N-isopropylacrylamide; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate