Cytotoxic holostane-type triterpene glycosides from the sea cucumber Pentacta quadrangularis.
Two new holostane-type triterpene glycosides, named pentactasides I (1) and II (2), and a new natural product, pentactaside III (3), together with two known glycosides, philinopsides A (4) and B (5), were isolated from the sea cucumber Pentacta quadrangularis. Their structures were elucidated by extensive spectroscopic analysis and chemical evidences. Compounds 1 and 2 possess the same trisaccharide moiety which is a rare structural feature among naturally occurring sea cucumber glycosides and has been infrequently reported, while 3 is a sulfated diglycoside. All the glycosides showed significant in vitro cytotoxicities against six tumor cell lines (P-388, A-549, MCF-7, MKN-28, HCT-116, and U87MG) with IC(50) in the range of 0.60-3.95 µM.
Han
Hua
H
College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
Xu
Qiang-Zhi
QZ
Tang
Hai-Feng
HF
Yi
Yang-Hua
YH
Gong
Wei
W
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D006027:Glycosides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D012503:Saponins / Q000302:isolation & purification / Q000627:therapeutic use; D012616:Sea Cucumbers / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D006027:Glycosides; D012503:Saponins; D014315:Triterpenes; C500379:philinopside A