[Centrosomes, mitotic spindle and cancer: find the odd one out!].
Centrosomes are essential protagonists during cell division through microtubule nucleation and spindle formation which are key to the harmonious distribution of sister chromatids in the two daughter cells. However, during the past decade, a wealth of new observations has extended their role beyond mitosis, particularly in the asymmetrical partition of cell fate determinants. Remarkably, asymmetric centrosome inheritance per se, through the segregation of differently aged mother -centrioles, seems to regulate the differential behaviour of daughter cells, in part through asynchronous expression of primary cilia, governing the response to environmental signals. It is thus understandable why any quantitative or qualitative dysfunction of centrioles contributes to genomic -instability and thus -tumorigenesis.
Romé
Pierre
P
Institut de génétique et développement de Rennes, UMR 6061, Faculté de médecine, professeur Léon Bernard, CS 34317, 35043 Rennes Cedex, France. pierre.rome@univ-rennes1.fr
Prigent
Claude
C
Giet
Régis
R
D000782:Aneuploidy; D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002502:Centrioles / Q000502:physiology; D018385:Centrosome / Q000502:physiology*; D002923:Cilia / Q000502:physiology; D004331:Drosophila melanogaster / Q000166:cytology / Q000235:genetics; D030342:Genetic Diseases, Inborn / Q000235:genetics / Q000473:pathology; D006801:Humans; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000166:cytology; D008941:Spindle Apparatus / Q000502:physiology*; D013234:Stem Cells / Q000166:cytology