Screening for glucose-6-phosphate dehydrogenase deficiency in blood donors.
OBJECTIVE
Our purpose was to determine the frequency of glucose-6-phosphate dehydrogenase (G6PD) deficiency in blood donors of Jahrom, Iran.


METHODS
Blood samples were obtained from the 706 blood donors who referred to Jahrom Blood Transfusion Organization between June and September 2008. Enzyme assays were performed three times, on day 1 (day of blood sampling), 7 and 45 days after blood storage. G6PD activity was measured using a quantitative assay.


RESULTS
A total of 706 samples were examined. 97.7% males and 2.3% females, mean age 32.6 years (18-64 years). Based on enzyme activity less than 1.62 IU/g hemoglobin (Hb), prevalence of G6PD deficiency in three separate measurements was 16.3, 19.1 and 33.3% respectively. Four percent of donor had an enzyme level of zero on day 1 which increased to 7.4 and 10.7% on the seventh and the forty-fifth days.


CONCLUSIONS
The results of this study support the screening for G6PD as part of the routine workup of blood donors in areas with a high prevalence of G6PD deficiency.
Emamghorashi
Fatemeh
F
Shiraz Nephrology Urology Research Center, Jahrom University of Medical Sciences, Jahrom, Iran. ghoraishy@yahoo.com
Hoshmand
Farhang
F
Mohtashamifar
Abdolrahman
A
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D005006:Ethnicity / Q000706:statistics & numerical data; D005260:Female; D005952:Glucose-6-Phosphatase / Q000097:blood; D005953:Glycogen Storage Disease Type I / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology* / Q000208:ethnology; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D055815:Young Adult
D005952:Glucose-6-Phosphatase