Monocytes in metabolic disorders--opportunities for flow cytometry contributions.
Chronic inflammation has arised as a major underlying cause of atherosclerosis, obesity and diabetes. It is mediated by cells of innate immune system like macrophages but also by their antecedents, circulating monocytes. Roles of monocyte subsets and different markers of monocyte activation in the context of metabolic disorders have been reviewed. Applying cell based approach through flow cytometry in this field has resulted with new understanding of pathophysiologic mechanisms. Possible implications of these insights in diagnosis, prognosis and revealing of therapeutic targets in metabolic disorders remain a challenge for future.
Pandzić Jaksić
Vlatka
V
Department of Endocrinology and Metabolism, University Hospital Dubrava, Zagreb, Croatia. vpandzic@kbd.hr
Gizdić
Branimir
B
Miletić
Zorana
Z
Ostović
Karmen Trutin
KT
Jaksić
Ozren
O
D050197:Atherosclerosis / Q000276:immunology / Q000473:pathology; D005434:Flow Cytometry; D006801:Humans; D008659:Metabolic Diseases / Q000276:immunology* / Q000473:pathology*; D009000:Monocytes / Q000473:pathology*; D009765:Obesity / Q000276:immunology / Q000473:pathology