title: Prolonged hyperkalemia following unilateral adrenalectomy for primary hyperaldosteronism.
abstract: Hypokalemia associated with aldosterone-producing adenomas (APA) are almost corrected following successful unilateral adrenalectomy. Prolonged hyperkalemia after unilateral adrenalectomy is rarely reported and may be overlooked. We describe a 62-year-old man who presented with fatigue and dizziness 2 weeks after unilateral adrenalectomy for aldosterone-producing adenomas. Physical examination showed decreased skin turgor and postural hypotension. Laboratory studies revealed hyperkalemia (6.3 mmol/l) with a low transtubular potassium gradient of 5. A relatively low plasma aldosterone concentration and high plasma renin activity in the setting of normal plasma cortisol and adrenocorticotropic hormone levels lead to a diagnosis of functional hypoaldosteronism. Fludrocortisone 0.2 mg/day for one week completely corrected his hyperkalemia which recurred after cessation of fludrocortisone. Long-term suppression of contralateral aldosterone synthesis by APA and/or chronic untreated hypokalemia may have accounted for the development of prolonged hyperkalemia after unilateral adrenalectomy. Serum potassium concentration following unilateral adrenalectomy must be meticulously monitored to avoid life-threatening hyperkalemia.
authors.affiliation: Department of Internal Medicine, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan, R.O.C.
authors.forename: W-T
authors.initials: WT
authors.lastname: Huang
authors.forename: T
authors.initials: T
authors.lastname: Chau
authors.forename: S-T
authors.initials: ST
authors.lastname: Wu
authors.forename: S-H
authors.initials: SH
authors.lastname: Lin
mesh_terms: D000236:Adenoma / Q000601:surgery*; D000310:Adrenal Gland Neoplasms / Q000601:surgery*; D000315:Adrenalectomy / Q000009:adverse effects*; D006801:Humans; D006929:Hyperaldosteronism / Q000175:diagnosis / Q000209:etiology / Q000601:surgery*; D006947:Hyperkalemia / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D013997:Time Factors