title: Essential fatty acid deficiency reduces cortical spreading depression propagation in rats: a two-generation study.
abstract: Cortical spreading depression (CSD) propagation was investigated in rats under dietary essential fatty acid (EFA) deficiency over two generations (F1 and F2). Wistar rat dams received diets containing 5% fat either from coconut-oil (EFA-deficient) or soybean-oil (control). F1-pups received their dams' diets until the day of CSD recording (30-40 days or 90-100 days). F2-pups were kept on their F1 dams' diet until 30-40 days. Compared to the controls, the EFA-deficient group had reduced (P < 0.05) body weights in both F1 and F2 conditions. This effect was more conspicuous (P < 0.001) in the F2-animals where brain weight was also reduced (P < 0.05). All EFA-deficient groups displayed lower CSD velocities (P < 0.001) than the corresponding controls. Within the same dietary group and generation, F1 young rats showed higher CSD velocities (P < 0.001) than adults. Data show that EFA deficiency reduces CSD propagation, and this effect is long lasting as it persists up to the second generation.
authors.affiliation: Laboratório de Fisiologia da Nutrição Naíde Teodósio, Departamento de Nutrição, Universidade Federal de Pernambuco, Recife, PE 50670-901, Brazil. jucarrazzone@gmail.com
authors.forename: Juliana Maria Carrazzone
authors.initials: JM
authors.lastname: Borba
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Rocha-de-Melo
authors.forename: Angela Amâncio
authors.initials: AA
authors.lastname: dos Santos
authors.forename: Belmira Lara da Silveira Andrade
authors.initials: BL
authors.lastname: da Costa
authors.forename: Reginaldo Pereira
authors.initials: RP
authors.lastname: da Silva
authors.forename: Priscila Pereira
authors.initials: PP
authors.lastname: Passos
authors.forename: Rubem Carlos Araújo
authors.initials: RC
authors.lastname: Guedes
mesh_terms: D000375:Aging; D000818:Animals; D001835:Body Weight; D001921:Brain / Q000473:pathology; D013181:Cortical Spreading Depression / Q000502:physiology*; D004569:Electroencephalography; D005228:Fatty Acids, Essential / Q000172:deficiency*; D005260:Female; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D009929:Organ Size; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005228:Fatty Acids, Essential