[Effects of silver sulfadiazine, ipê roxo (tabebuia avellanedae) extract and barbatimão (stryphnodendron adstringens) extract on cutaneous wound healing in rats].
OBJECTIVE
Morphological study of effects of silver sulfadiazine, Tabebuia avellanedae (ipê-roxo) extract and Stryphnodendron adstringens (barbatimão) extract on cutaneous wound healing was done.


METHODS
Ninety six Wistar rats were used. All animals underwent a femoral right vein ligation to induce a venous hypertension. Thirty days after the cutaneous wound was done, they were divided into groups of four animals. Group S received silver sulfadiazine topical application; group IR, Tabebuia avellanedae extract topical application; group B received Stryphnodendron adstringens extract topical application and group C received physiological solution topical application, every day for a period of seven, 14 and 30 days. Histology analyzed the presence vascular proliferation, neutrophil and lymphocite, fibroblast, collagen fiber and epithelization.


RESULTS
The macroscopic analysis showed complete epithelization at 14 days in group S, IR e B. The histological data at 14 days of observation only group C still showed incomplete epithelization in six animals. At the same period there was a statistic significant difference between the control group and the others groups as inflammation process and neovascularization. About the presence fibroblasts and collagen, there was statistic significant difference between the control group and the others groups at the 30 days because at this period the control group still showed fibroblasts and collagen lower when compared to the others groups.


CONCLUSIONS
The morphological analysis of the results permits to infer that the group S, IR and B had a better healing of skin wounds, when compared with the control.
Coelho
Julice Medeiros
JM
Universidade Federal de Mato Grosso do Sul. julicecoelho@hotmail.com
Antoniolli
Andréia Brochado
AB
Nunes e Silva
Daniel
D
Carvalho
Themis Maria Milan Brochado
TM
Pontes
Elenir Rose Jardim Cury
ER
Odashiro
Alexandre Nakao
AN
D000818:Animals; D007887:Fabaceae; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012837:Silver Sulfadiazine / Q000627:therapeutic use*; D012867:Skin / Q000187:drug effects* / Q000293:injuries*; D029663:Tabebuia; D014945:Wound Healing / Q000187:drug effects*
D010936:Plant Extracts; D012837:Silver Sulfadiazine