title: Profound reduction of invariant natural killer T cells in the peripheral blood of a patient with interleukin-1 receptor-associated kinase 4 deficiency.
abstract: We previously described a patient with a history of frequent life-threatening pneumonias, infections with bacterial pathogens, interleukin 1 receptor-associated kinase 4 deficiency, and failure to maintain antibody titers to polysaccharide antigens or to a neoantigen bacteriophage. In the present study, we show that the patient's peripheral blood mononuclear cells have a profound deficiency of invariant natural killer T cells.
authors.forename: Soichi
authors.initials: S
authors.lastname: Haraguchi
authors.forename: Noorbibi K
authors.initials: NK
authors.lastname: Day
authors.forename: Nutthapong
authors.initials: N
authors.lastname: Tangsinmankong
authors.forename: John W
authors.initials: JW
authors.lastname: Sleasman
mesh_terms: D001424:Bacterial Infections / Q000276:immunology; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007113:Immunity, Innate; D007153:Immunologic Deficiency Syndromes / Q000276:immunology* / Q000503:physiopathology*; D007375:Interleukin-1; D053592:Interleukin-1 Receptor-Associated Kinases / Q000172:deficiency*; D055611:Natural Killer T-Cells / Q000276:immunology*
chemical_list: D007375:Interleukin-1; D053592:Interleukin-1 Receptor-Associated Kinases