Lysidicins F-H, three new phloroglucinols from Lysidice rhodostegia.
Three new phloroglucinols, named lysidicins F-H (1-3), were isolated from the roots of Lysidice rhodostegia. These compounds have a unprecedented benzyl benzo[b]furo[3,2-d]furan skeleton, and lysidicin F (1) is the first example of natural product with trans-fused furan rings. Their structures were established on the basis of extensive spectroscopic analysis, and the absolute configurations of them were determined by computational methods. A possible biosynthetic pathway for 1-3 was also postulated.
Wu
Xian-Fu
XF
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College (Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education), Beijing 100050, PR China.
Hu
You-Cai
YC
Yu
Shi-Shan
SS
Jiang
Nan
N
Ma
Jing
J
Tan
Ren-Xiang
RX
Li
Yong
Y
Lv
Hai-Ning
HN
Liu
Jing
J
Ma
Shuang-Gang
SG
D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification*; D003198:Computer Simulation; D007887:Fabaceae / Q000737:chemistry*; D008956:Models, Chemical; D008968:Molecular Conformation; D010696:Phloroglucinol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification; D018517:Plant Roots / Q000737:chemistry; D013237:Stereoisomerism
D000975:Antioxidants; C551379:lysidicin F; C551380:lysidicin G; C551381:lysidicin H; D010696:Phloroglucinol