title: Primary nasopharyngeal Hodgkin's disease: case report and literature review.
abstract: BACKGROUND
  Primary Hodgkin's disease of the nasopharynx is a rare and uncommon event. It has a relatively favorable prognosis and represents less than 1% of all documented cases of Hodgkin's disease.
  
  
  METHODS
  A 40-year-old Arabic man presented initially with bilateral nasal obstruction, which was then followed by a significant involvement of his bilateral cervical lymph nodes. His nasopharyngeal biopsy together with immunohistochemistry analysis showed negative expressions of CD15, CD20 and CD3, but positive expressions of CD30 and epithelial membrane antigen. This confirmed the diagnosis of nasopharyngeal Hodgkin's disease of a mixed cellularity subtype. The disease was at stage IIEA. Our patient received four cycles of chemotherapy, which yielded a 75% response. This was followed by irradiation of his Waldeyer's ring and supraclavicular lymph nodes. He remains in good local control after 30 months of follow-up.
  
  
  CONCLUSIONS
  The literature review and our case report discuss the optimal management of this rare and atypical localization of Hodgkin's disease, which should be differentiated from lymphoproliferations associated with Epstein-Barr virus and non-Hodgkin's lymphoma.
authors.affiliation: Department of Medical Oncology, National Institute of Oncology, Rabat, Morocco. yoss.onco@hotmail.com.
authors.forename: Youssef
authors.initials: Y
authors.lastname: Bensouda
authors.forename: Kawtar
authors.initials: K
authors.lastname: El Hassani
authors.forename: Nabil
authors.initials: N
authors.lastname: Ismaili
authors.forename: Issam
authors.initials: I
authors.lastname: Lalya
authors.forename: Saber
authors.initials: S
authors.lastname: Boutayeb
authors.forename: Nourredine
authors.initials: N
authors.lastname: Benjaafar
authors.forename: Brahim Khalil
authors.initials: BK
authors.lastname: El Gueddari
authors.forename: Hassan
authors.initials: H
authors.lastname: Errihani