title: Thymine, adenine and lipoamino acid based gene delivery systems.
abstract: A novel class of thymine, adenine and lipoamino acid based non-viral carriers for gene delivery has been developed. Their ability to bind to DNA by hydrogen bonding was confirmed by NMR diffusion, isothermal titration calorimetry and transmission electron microscopy experiments.
authors.affiliation: The University of Queensland, School of Chemistry and Molecular Biosciences, Qld 4072, Brisbane, Australia.
authors.forename: Mariusz
authors.initials: M
authors.lastname: Skwarczynski
authors.forename: Zyta M
authors.initials: ZM
authors.lastname: Ziora
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Coles
authors.forename: I-Chun
authors.initials: IC
authors.lastname: Lin
authors.forename: Istvan
authors.initials: I
authors.lastname: Toth
mesh_terms: D000225:Adenine / Q000737:chemistry* / Q000378:metabolism; D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism; D004247:DNA / Q000008:administration & dosage* / Q000378:metabolism; D018014:Gene Transfer Techniques; D006860:Hydrogen Bonding; D008055:Lipids / Q000737:chemistry; D013941:Thymine / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000596:Amino Acids; D008055:Lipids; D004247:DNA; D000225:Adenine; D013941:Thymine