Tandem Michael addition/intramolecular isocyanide [3 + 2] cycloaddition: highly diastereoselective one pot synthesis of fused oxazolines.
A base-catalyzed tandem Michael addition/intramolecular isocyanide [3 + 2] cycloaddition of ethyl isocyanoacetate and Michael acceptors with tethered carbonyl groups is described. This reaction leads to the formation of fused oxazolines in a highly diastereoselective manner under very mild conditions.
Zhang
Lingjuan
L
Department of Chemistry, Northeast Normal University, Changchun 130024, China.
Xu
Xianxiu
X
Tan
Jing
J
Pan
Ling
L
Xia
Wenming
W
Liu
Qun
Q
D003486:Cyanides / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D003486:Cyanides; D010080:Oxazoles