Change in renal function after sodium phosphate preparation for screening colonoscopy.
OBJECTIVE
To investigate the changes in renal function at 12-24 mo in patients following sodium phosphate (NaP) preparation for screening colonoscopy.


METHODS
We carried out a retrospective study on the results from patients who received health check-up services as part of an employer-provided wellness program performed between August 2006 and May 2008 and who were followed up for 12-24 mo. Prior to screening colonoscopy, 224 patients underwent bowel cleansing with NaP (NaP group) and 113 patients with polyethylene glycol (PEG group). The control group comprised 672 age-matched patients. We compared the changes in the creatinine levels and the glomerular filtration rates (GFRs) from baseline to 12-24 mo between the NaP, PEG, and control groups using two-way repeated measured analysis of variance. In addition, multivariate linear regression analysis was performed to assess the risk factors for a decreased GFR.


RESULTS
The baseline mean serum creatinine level in the NaP, PEG, and control groups was 1.12 +/- 0.15, 1.12 +/- 0.16, and 1.12 +/- 0.15 mg/dL, which increased to 1.15 +/- 0.15, 1.15 +/- 0.18, and 1.15 +/- 0.15 mg/dL, respectively, after 12-24 mo. The baseline mean GFR in the NaP, PEG, and control groups was 69.0 +/- 7.7, 68.9 +/- 8.0, and 69.6 +/- 6.7 mL/min per 1.73 m(2), which decreased to 66.5 +/- 7.8, 66.5 +/- 8.3, and 67.4 +/- 6.4 mL/min per 1.73 m(2), respectively, after 12-24 mo. The changes in serum creatinine levels and GFRs were not significantly between the NaP, PEG, and control groups (P = 0.992 and P = 0.233, respectively). Using multivariate linear regression analysis, only the baseline GFR was associated with the change in GFR (P < 0.001). Indeed, the bowel preparations were not associated with the change in GFR (P = 0.297).


CONCLUSIONS
NaP bowel preparation in subjects with normal renal function was not associated with renal injury, and NaP can thus be used safely for screening colonoscopy.
Seol
Dong Choon
DC
Healthcare Center, Konkuk University Medical Center, Department of Internal Medicine, Konkuk University School of Medicine, Medical Immunology Center, Institute of Biomedical Science and Technology, 4-12 Hwayang-dong, Gwangjin-gu, Seoul, South Korea.
Hong
Sung Noh
SN
Kim
Jeong Hwan
JH
Sung
In Kyung
IK
Park
Hyung Seok
HS
Lee
Jung Hyun
JH
Shim
Chan Sup
CS
D000328:Adult; D015331:Cohort Studies; D003113:Colonoscopy / Q000379:methods*; D003404:Creatinine / Q000737:chemistry; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010710:Phosphates / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000737:chemistry; D012189:Retrospective Studies; D013997:Time Factors
D010710:Phosphates; D011092:Polyethylene Glycols; D003404:Creatinine; C018279:sodium phosphate