A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity.
A library of 4,5-disubstituted-2-aminoimidazoles was synthesized using a nitroenolate route and then screened for antibiofilm and antimicrobial activity. These compounds displayed notable biofilm dispersal and planktonic microbicidal activity against various Gram-positive and Gram-negative bacteria.
Su
Zhaoming
Z
Department of Chemistry, North Carolina State University, Raleigh, USA.
Rogers
Steven A
SA
McCall
W Steve
WS
Smith
Alicia C
AC
Ravishankar
Sindhu
S
Mullikin
Trey
T
Melander
Christian
C
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018441:Biofilms; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000502:physiology; D007093:Imidazoles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D007093:Imidazoles; C014973:2-aminoimidazole