Survival time and prognostic factors of oral cancer in Ubon Ratchathani Cancer Center.
OBJECTIVE
To characterize the survival time and prognostic factors of oral cancer in Ubon Ratchathani, Thailand.


METHODS
A total of 519 patients with oral cancer in the Ubon Ratchathani Cancer Center were recruited retrospectively over 5 years, from January 1, 2002 to December 31, 2006. The survival status of the patients was followed until December 31, 2007. Survival times were estimated and compared using the product-limit (Kaplan-Meier) method Cox Proportional Hazards models were used to examine prognostic factors.


RESULTS
At the end of the study, 384 patients (74.0%) had died. The mean age of the patients at diagnosis was 64.15 years, with a male to female ratio of 1:1.56. Location of cancer were found at tongue (25.2%), buccal mucosa (22.4%), gum (21.1%), lip (17.5%) and others (13.7%). Squamous cell carcinoma was the most common cell type (92.7%). The median survival time was 337 days and the survival probability at 1, 3 and 5-years were 46.7%, 26.4% and 18.2%, respectively. In multivariable analysis, patients at the greatest risk of death were those having cancer of the tongue (HR 1.93, 1.20, 3.11) compared to cancer of the lip and being in stage IV at diagnosis (HR 3.57, 95% CI = 1.79, 7.13) as compared to stage I.


CONCLUSIONS
Patients with advanced tumors had the worst prognosis, underscoring the importance of improved early detection for early treatment.
Kruaysawat
Watcharin
W
Srimuangmai Hospital, Ubon Ratchathani, Thailand.
Aekplakorn
Wichai
W
Chapman
Robert S
RS
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000401:mortality*; D002610:Cheek; D005260:Female; D005882:Gingival Diseases / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008048:Lip Neoplasms; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa; D009062:Mouth Neoplasms / Q000401:mortality*; D015999:Multivariate Analysis; D011379:Prognosis; D013785:Thailand / Q000453:epidemiology; D014062:Tongue Neoplasms / Q000401:mortality