title: Molecular diversity of toxic components from the scorpion Heterometrus petersii venom revealed by proteomic and transcriptome analysis.
abstract: Scorpion venoms contain a vast untapped reservoir of natural products, which have the potential for medicinal value in drug discovery. In this study, toxin components from the scorpion Heterometrus petersii venom were evaluated by transcriptome and proteome analysis.Ten known families of venom peptides and proteins were identified, which include: two families of potassium channel toxins, four families of antimicrobial and cytolytic peptides,and one family from each of the calcium channel toxins, La1-like peptides, phospholipase A2,and the serine proteases. In addition, we also identified 12 atypical families, which include the acid phosphatases, diuretic peptides, and ten orphan families. From the data presented here, the extreme diversity and convergence of toxic components in scorpion venom was uncovered. Our work demonstrates the power of combining transcriptomic and proteomic approaches in the study of animal venoms.
authors.affiliation: College of Life Sciences, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Yibao
authors.initials: Y
authors.lastname: Ma
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhao
authors.forename: Ruiming
authors.initials: R
authors.lastname: Zhao
authors.forename: Weiping
authors.initials: W
authors.lastname: Zhang
authors.forename: Yawen
authors.initials: Y
authors.lastname: He
authors.forename: Yingliang
authors.initials: Y
authors.lastname: Wu
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Cao
authors.forename: Lin
authors.initials: L
authors.lastname: Guo
authors.forename: Wenxin
authors.initials: W
authors.lastname: Li
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D020869:Gene Expression Profiling; D008969:Molecular Sequence Data; D040901:Proteomics; D012604:Scorpion Venoms / Q000032:analysis* / Q000737:chemistry / Q000235:genetics / Q000633:toxicity; D012605:Scorpions / Q000033:anatomy & histology / Q000737:chemistry* / Q000235:genetics; D016415:Sequence Alignment
chemical_list: D012604:Scorpion Venoms