Mechanisms of translational regulation in synaptic plasticity.
The plasticity of the nervous system is due to the ability of neurons to change their properties by altering the function of their proteome. A major mechanism for this is through altering the amount of proteins by regulating their translation. In this review, we focus on recent advances in the elucidation of the mechanisms by which neurons regulate translation during synaptic plasticity. Particular focus will be on the different transduction mechanisms that selectively target distinct elements of the mRNA in the regulation of translation during plasticity.
Sossin
Wayne S
WS
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec H3A 2B4, Canada. Wayne.sossin@mcgill.ca
Lacaille
Jean-Claude
JC
D000818:Animals; D001921:Brain / Q000166:cytology*; D005786:Gene Expression Regulation / Q000502:physiology*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism; D008954:Models, Biological; D009473:Neuronal Plasticity / Q000502:physiology*; D010766:Phosphorylation; D021381:Protein Transport / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology
D035683:MicroRNAs; D014157:Transcription Factors