[Analysis of the risk factors for hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation for beta-thalassemia in children].
OBJECTIVE
To analyze the risk factors of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation for beta-thalassemia in children.


METHODS
The clinical records of 30 children with beta-thalassemia undergoing allogeneic hematopoietic stem cell transplantation between December, 2008 and November, 2009 were analyzed.


RESULTS
Hemorrhagic cystitis occurred in 8 of the 33 patients with an incidence of 24.24%, including 1 with grade I, 6 with grade II and 1 with grade III hemorrhagic cystitis. The median time of hemorrhagic cystitis onset was 22.9 days (range 6-35 days) and the median duration was 11.9 days(range 3-27 days). Univariate analysis indicated that the different types of transplantation and acute graft-versus-host disease affect the occurrence of hemorrhagic cystitis. The children with Allo-PBSCT had higher incidence than those receiving Allo-PBSCT+Allo-UBT and Allo-BMT (P<0.05). The children at an age >or=6 years had obviously higher incidence of hemorrhagic cystitis than those at younger ages.


CONCLUSIONS
Age is the major factor that affects the occurrence of hemorrhagic cystitis in children undergoing allogeneic hematopoietic stem cell transplantation for beta-thalassemia.
Yin
Wen-fang
WF
Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Pei
Fu-yu
FY
Wu
Xue-dong
XD
Liu
Si-xi
SX
He
Yue-lin
YL
Liao
Jian-yun
JY
Li
Na
N
Chen
Ge-yu
GY
Feng
Xiao-qing
XQ
Li
Chun-fu
CF
D000367:Age Factors; D002648:Child; D002681:China / Q000453:epidemiology; D003556:Cystitis / Q000453:epidemiology / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D012307:Risk Factors; D014184:Transplantation, Homologous; D017086:beta-Thalassemia / Q000628:therapy*