Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis.
Amyloid plaques and neurofibrillary tangles are the hallmarks of Alzheimer's disease and have been the focus of disease etiology and pathogenesis. However, in the larger picture of a complex disease, the precise etiology of the lesions per se, as well as the clinical disease, remain to be defined. In this regard, to date no single process has been identified as a useful target and treatment efforts have shown no meaningful progress. Therefore, alternative ideas that may lead to new and effective treatment options are much needed.
Mondragón-Rodríguez
Siddhartha
S
Département de Physiologie, Université de Montréal, Québec, Canada.
Basurto-Islas
Gustavo
G
Lee
Hyoung-gon
HG
Perry
George
G
Zhu
Xiongwei
X
Castellani
Rudy J
RJ
Smith
Mark A
MA
D000544:Alzheimer Disease / Q000209:etiology* / Q000235:genetics / Q000473:pathology* / Q000628:therapy; D016229:Amyloid beta-Peptides / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D006801:Humans; D008954:Models, Biological; D016874:Neurofibrillary Tangles / Q000473:pathology; D018384:Oxidative Stress / Q000502:physiology; D058225:Plaque, Amyloid / Q000473:pathology; D016875:tau Proteins / Q000378:metabolism
D016229:Amyloid beta-Peptides; D002800:Cholinesterase Inhibitors; D016875:tau Proteins