title: The perioperative von Willebrand factor activity and factor VIII levels among alcohol use disorder patients undergoing total knee or hip replacement.
abstract: Alcohol use disorder patients have a five-fold higher risk of postoperative bleeding complications. We measured the perioperative von Willebrand factor and factor VIII levels in consecutive patients with alcohol use disorder. In one university hospital, 105 patients scheduled for arthroplasty were screened, and 25 fulfilled inclusion criteria. Postoperatively, we found significantly decreased von Willebrand factor ristocetin cofactor values over time among alcohol use disorder patients and significantly different time courses of factor VIII levels between patients with and without a diagnosed alcohol use disorder. Blood loss was significantly increased among alcohol use disorder patients on their first postoperative day.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Charité-Universitaetsmedizin Berlin, Charité Campus Mitte and Campus Virchow-Klinikum, Berlin, Germany. helge.schoenfeld@charite.de
authors.forename: Helge
authors.initials: H
authors.lastname: Schoenfeld
authors.forename: Carsten
authors.initials: C
authors.lastname: Perka
authors.forename: Sabine
authors.initials: S
authors.lastname: Ziemer
authors.forename: Ranja
authors.initials: R
authors.lastname: Huebner
authors.forename: Tania
authors.initials: T
authors.lastname: Schink
authors.forename: Bruno
authors.initials: B
authors.lastname: Neuner
authors.forename: Claudia
authors.initials: C
authors.lastname: Spies
mesh_terms: D000368:Aged; D000437:Alcoholism; D019644:Arthroplasty, Replacement, Hip; D019645:Arthroplasty, Replacement, Knee; D005169:Factor VIII / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care; D011183:Postoperative Complications / Q000097:blood*; D014842:von Willebrand Diseases
chemical_list: D005169:Factor VIII