title: Seven new vernocuminosides from the stem bark of Vernonia cumingiana Benth.
abstract: Seven new stigmastane-type steroidal glycosides, vernocuminosides H-N, have been isolated from the stem bark of Vernonia cumingiana Benth. The structures of these compounds were determined by NMR spectrometric methods including HSQC, HMBC, (1)H-(1)H COSY, and NOE, as well as circular dichroism experiments. Anti-inflammatory activities of vernocuminosides I and K-N were determined.
authors.affiliation: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Xiannongtan Street, Beijing, People's Republic of China.
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Shuanggang
authors.initials: S
authors.lastname: Ma
authors.forename: Shishan
authors.initials: S
authors.lastname: Yu
authors.forename: Haining
authors.initials: H
authors.lastname: Lv
authors.forename: Yong
authors.initials: Y
authors.lastname: Li
authors.forename: Xianfu
authors.initials: X
authors.lastname: Wu
authors.forename: Yuanyan
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D024301:Plant Bark / Q000737:chemistry*; D051381:Rats; D035741:Vernonia / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D006027:Glycosides