title: Ex vivo study of the home-use TriPollar RF device using an experimental human skin model.
abstract: BACKGROUND
  A wide variety of professional radio frequency (RF) aesthetic treatments for anti-aging are available aiming at skin tightening. A new home-use RF device for facial treatments has recently been developed based on TriPollar technology.
  
  
  OBJECTIVE
  To evaluate the mechanism of the new home-use device, in the process of collagen remodeling, using an ex vivo skin model.
  
  
  METHODS
  Human skin samples were collected in order to evaluate the anti-aging effect of a home-use device for facial treatments on an ex vivo human skin model. Skin tightening was evaluated by dermal histology, quantitative analysis of collagen fibers and dosage of collagen synthesis.
  
  
  RESULTS
  Significant collagen remodeling following RF treatment with the device was found in the superficial and mid-deep dermis. Biochemical measurement of newly synthesized collagen showed an increase of 41% in the treated samples as compared to UV-aged control samples.
  
  
  CONCLUSIONS
  The new home-use device has been demonstrated to affect significant collagen remodeling, in terms of the structural and biochemical improvement of dermal collagen on treated skin samples.
authors.affiliation: Pitié Salpétrière Hospital, Paris, France. gredeco@orange.fr
authors.forename: Sylvie
authors.initials: S
authors.lastname: Boisnic
authors.forename: Marie Christine
authors.initials: MC
authors.lastname: Branchet
mesh_terms: D003094:Collagen / Q000378:metabolism*; D004867:Equipment Design; D006801:Humans; D066298:In Vitro Techniques; D000078702:Radiofrequency Therapy; D012060:Rejuvenation; D012648:Self Care / Q000295:instrumentation*; D012867:Skin / Q000378:metabolism* / Q000528:radiation effects; D015595:Skin Aging / Q000528:radiation effects*
chemical_list: D003094:Collagen