G-quadruplex signaling probe for highly sensitive DNA detection.
Ferrocene-conjugated oligonucleotides that can form intermolecular guanine (G)-quadruplexes are prepared and used as signaling probes for detecting target DNA, improving substantially assay characteristics (e.g. a considerably wider linear dynamic range and lower detection limit).
Zhang
Songbai
S
State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, PR China.
Wu
Zai-Sheng
ZS
Qiu
Liping
L
Zhou
Hui
H
Shen
Guoli
G
Yu
Ruqin
R
D004247:DNA / Q000032:analysis*; D005296:Ferrous Compounds / Q000737:chemistry; D054856:G-Quadruplexes; D006147:Guanine / Q000737:chemistry; D000075163:Metallocenes; D015341:Nucleic Acid Probes / Q000737:chemistry*; D009841:Oligonucleotides / Q000737:chemistry; D012680:Sensitivity and Specificity
D005296:Ferrous Compounds; D000075163:Metallocenes; D015341:Nucleic Acid Probes; D009841:Oligonucleotides; D006147:Guanine; D004247:DNA; C004998:ferrocene