title: fMRI study of effect on brain activity according to stimulation method at LI11, ST36: painful pressure and acupuncture stimulation of same acupoints.
abstract: OBJECTIVE
  The objective of this study was to assess differences in brain responses between pressure and acupuncture stimulation at the same acupoint using functional magnetic resonance imaging (fMRI).
  
  
  METHODS
  A total of 10 healthy right-handed volunteers were studied.
  
  
  METHODS
  fMRI was performed with two different paradigms; namely, pressure and acupuncture stimulation at acupuncture points LI11 and ST36 on the left. fMRI data were analyzed using SPM2.
  
  
  RESULTS
  In comparison with the left LI11 pressure stimulation, both sides of the parahippocampal gyrus, cerebellum, left side of thalamus, and right side of posterior cingulate regions were more activated by the left LI11 acupuncture stimulation. In comparison with the left ST36 pressure stimulation, the secondary motor cortex, limbic system (cingulate gyrus, posterior cingulate), primary visual cortex, pons, and medulla regions were more activated by left ST36 acupuncture stimulation. In comparison with the left ST36 pressure stimulation, both side of BA 4 and BA 6 were more activated by the LI11 pressure stimulation. In comparison with the left LI11 acupuncture stimulation, left BA 6, BA 8, and anterior cingulate cortex (ACC) were more activated by the left ST36 acupuncture stimulation.
  
  
  CONCLUSIONS
  In conclusion, brain signal activation patterns according to the stimulation methods and acupoints were observed to differ. Acupuncture stimulation activated more regions than pressure at the same acupoint. In particular, acupuncture stimulation activated the limbic system, such as the parahippocampal gyrus and ACC.
authors.affiliation: Department of Cardiovascular & Neurologic Disease (Stroke Center), East-West Neo Medical Center, College of Korean Medicine, Kyung Hee University, Seoul, Korea.
authors.forename: Seung-Yeon
authors.initials: SY
authors.lastname: Cho
authors.forename: Geon-Ho
authors.initials: GH
authors.lastname: Jahng
authors.forename: Seong-Uk
authors.initials: SU
authors.lastname: Park
authors.forename: Woo-Sang
authors.initials: WS
authors.lastname: Jung
authors.forename: Sang-Kwan
authors.initials: SK
authors.lastname: Moon
authors.forename: Jung-Mi
authors.initials: JM
authors.lastname: Park
mesh_terms: D019050:Acupressure; D015669:Acupuncture Points; D015670:Acupuncture Therapy; D000368:Aged; D001921:Brain / Q000378:metabolism*; D001931:Brain Mapping; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009424:Nervous System Physiological Phenomena; D010146:Pain; D011312:Pressure