[The energy and fractal characteristics of the physiological and pathological tremors of man's hand].
The tasks was to execute the comparative analysis of involuntary fluctuations (tremor) that are appeared during sustaining of isometric effort by the hands at healthy man and exist at patients with the tremulous form of parkinsonism. For the decision of this task we have applied the fractal analysis and multilevel wavelet-decomposition of tremors with subsequent valuation of the energy characteristics determined on the basis of spectral density of energy of detailed components that can be received at different levels of decomposition. Have found that the computed fractal and energy quantities of tremor at healthy examinees were significantly less than the same characteristics at the patients. Introduction of antiparkinsonian drugs to patients in habitual for them drug doses results in the shifts of the characteristics to their values that approached to parameters of healthy volunteers. The decreasing of fractal dimension indicates about an increasing of correlatedness in dynamics of involuntary fluctuations and about "simplification" of process of motor control by the movements. Thus, the considered characteristics allow not only authentically to distinguish physiological and pathological tremors, but also to define strategy of individual choice of type and optimal drug dosages for effective decreasing of parkinsonian tremor.
Dik
O E
OE
Romanov
S P
SP
Nozdrachev
A D
AD
D000978:Antiparkinson Agents / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D005260:Female; D006225:Hand / Q000503:physiopathology*; D006801:Humans; D007537:Isometric Contraction; D008297:Male; D008875:Middle Aged; D020734:Parkinsonian Disorders / Q000188:drug therapy / Q000503:physiopathology*; D014202:Tremor / Q000188:drug therapy / Q000503:physiopathology*
D000978:Antiparkinson Agents