[Epidemiological study, pathologic evaluation and prognostic factors of colorectal mucinous vs non-mucinous adenocarcinoma (a series of 196 patients)].
BACKGROUND
Colorectal carcinoma is one of the main causes of cancer death in the worldwide with a decrease survival rate in relationship with a later diagnosis of advanced disease.


OBJECTIVE
This study highlights the particular epidemiological, clinicopathological and immunohistochemical colorectal cancer profile. Indeed, our results differ markedly from that reported in the literature.


METHODS
We underwent a retro and prospective study interesting 196 patients with colorectal carcinoma diagnosed in the pathological and cytological laboratory of Mongi Slim Hospital (Tunisia). Age at diagnosis, mode of presentation, sex, tumour location, macroscopic and histological features, TNM and Astler Coller stage were assessed and evaluated.


RESULTS
We report here a particular epidemiological pattern which is characterised by younger age of the patients, equally distribution between men and women, predominant sporadic carcinomas and preponderance of rectosigmoid location. The poorer degree of differentiation and mucinous subtype are correlated with an advanced stage. It is also correlated with more frequent vascular embols, neural invasion and metastatic nodes. Furthermore, immunohistochemical analysis of galectin-3 showed a significant difference between mucinous and non mucinous adenocarcinoma.


CONCLUSIONS
Based on the presented data, the epidemiological pattern and the anatomic distribution especially in the rectosigmoid region suggest diet and lifestyle to be primordial risk factors of colorectal tumorigenesis.
Arfaoui Toumi
Amira
A
Unité de recherche (M.E.S.R.S): UR03ES04, CHU Mongi Slim La Marsa, Tunisie.
Kriaa Ben Mahmoud
Lilia
L
Khiari
Meriem
M
Lahmer
Ahlem
A
Gharbi
Lasaad
L
Dhraïef
Monia
M
Khalfallah
Tahar
T
Regaya Mzabi
Sabeh
S
Bouraoui
Saadia
S
D000230:Adenocarcinoma / Q000737:chemistry / Q000453:epidemiology* / Q000473:pathology*; D002288:Adenocarcinoma, Mucinous / Q000737:chemistry / Q000453:epidemiology* / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D012809:Colon, Sigmoid / Q000473:pathology; D015179:Colorectal Neoplasms / Q000737:chemistry / Q000453:epidemiology* / Q000473:pathology*; D005260:Female; D037502:Galectin 3 / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D012007:Rectum / Q000473:pathology; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D014416:Tunisia / Q000453:epidemiology
D014408:Biomarkers, Tumor; D037502:Galectin 3