title: Habituation in prepulse inhibition is affected by a polymorphism on the NMDA receptor 2B subunit gene (GRIN2B).
abstract: OBJECTIVE
  To identify the reliable connectivity between causal genes or variants with an abnormality expressed in a certain endophenotype has been viewed as a crucial step in unraveling the etiology of schizophrenia because of the considerable heterogeneity in this disorder.
  
  
  METHODS
  According to this practical and scientific demand, we aimed to investigate the relationship between seven top-ranked variants in the SZgene database [120-bpTR in DRD4, rs1801028 and rs6277 in DRD2, rs1019385 (T200G) in GRIN2B, rs1800532 in TPH1, rs1801133 (C677T) in MTHFR, rs2619528 (P1765) in DTNBP1] and prepulse inhibition (PPI) and habituation after acoustic stimulus (HAB).
  
  
  RESULTS
  Both PPI and HAB were decreased significantly in patients with schizophrenia. In addition, we observed a significant effect of GRIN2B (human NMDA receptor 2B subunit gene, NR2B) genotype on HAB (P<0.05, not corrected).
  
  
  CONCLUSIONS
  Although these findings need to be replicated in other samples, an underlying mechanism of impaired biological reaction may be influenced by NMDA hypofunctioning in schizophrenia.
authors.affiliation: Department of Neuropsychiatry, Osaka Medical College, Takatsuki, Osaka, Japan.
authors.forename: Akira
authors.initials: A
authors.lastname: Hokyo
authors.forename: Tetsufumi
authors.initials: T
authors.lastname: Kanazawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Uenishi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tsutsumi
authors.forename: Seiya
authors.initials: S
authors.lastname: Kawashige
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kikuyama
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Glatt
authors.forename: Jun
authors.initials: J
authors.lastname: Koh
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Nishimoto
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Matsumura
authors.forename: Naoyasu
authors.initials: N
authors.lastname: Motomura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yoneda
mesh_terms: D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D016194:Receptors, N-Methyl-D-Aspartate / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics / Q000503:physiopathology*
chemical_list: C121001:NR2B NMDA receptor; D016194:Receptors, N-Methyl-D-Aspartate