Bronchial thermoplasty: a novel technique in the treatment of severe asthma.
New therapies are needed for patients with severe persistent asthma who cannot achieve control with current therapy of inhaled corticosteroids and long-acting beta(2)-agonists. Bronchial thermoplasty is a novel intervention for asthma that delivers controlled thermal energy to the airway wall during a series of bronchoscopies, resulting in a prolonged reduction in airway smooth muscle mass. We review the method of performing bronchial thermoplasty with the Alair System, how to appropriately select and manage patients undergoing bronchial thermoplasty, and the clinical experience to date with this treatment. Randomized, controlled clinical trials with bronchial thermoplasty in subjects with severe asthma have resulted in improvements in overall asthma control as demonstrated by significant improvement in quality of life, asthma symptoms, severe exacerbations requiring corticosteroids, days lost from work/school/other daily activities due to asthma, and healthcare utilization.
Castro
Mario
M
Washington University School of Medicine, St Louis, MO 63110-1093, USA. castrom@wustl.edu
Musani
Ali I
AI
Mayse
Martin L
ML
Shargill
Narinder S
NS
D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery*; D001980:Bronchi / Q000503:physiopathology / Q000601:surgery*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology / Q000601:surgery*; D001999:Bronchoscopy / Q000379:methods; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D011788:Quality of Life; D016032:Randomized Controlled Trials as Topic; D012720:Severity of Illness Index; D016896:Treatment Outcome
D005938:Glucocorticoids