Immuno- and gene-therapeutic strategies targeted against cancer (mainly focusing on pancreatic cancer).
Current treatment modalities of surgical resection and chemotherapy against cancers have improved survival. However, mortality from tumor recurrence remains high. Immunotherapy and gene therapy are potential additions to the treatment arsenal in the care of cancer patients. These novel therapeutic approaches need further investigation in in vitro and in vivo models as they are developed for potential use in humans. Here we reviewed immunotherapies and gene therapies that included clinical trials against cancers (mainly focusing on pancreatic cancer) suggesting the strong possibility of using these novel approaches.
Yoshimura
Kiyoshi
K
Department of Surgery II, Yamaguchi University School of Medicine, Ube, Yamaguchi, Japan.
Olino
Kelly
K
Edil
Barish H
BH
Schulick
Richard D
RD
Oka
Masaaki
M
D000818:Animals; D019496:Cancer Vaccines; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009369:Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000276:immunology / Q000628:therapy*
D019496:Cancer Vaccines