Mitochondrial pathobiology in Parkinson's disease and amyotrophic lateral sclerosis.
Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS) are the second and third most common human adult-onset neurodegenerative diseases, respectively, after Alzheimer's disease. They are characterized by prominent age-related neurodegeneration in selectively vulnerable neural systems. Some forms of PD and ALS are inherited, and genes causing these diseases have been identified. Morphological, biochemical, and genetic, as well as cell and animal model, studies reveal that mitochondria could have a role in this neurodegeneration. The functions and properties of mitochondria might render subsets of selectively vulnerable neurons intrinsically susceptible to cellular aging and stress and overlying genetic variations. In PD, mutations in putative mitochondrial proteins have been identified and mitochondrial DNA mutations have been found in neurons in the substantia nigra. In ALS, changes occur in mitochondrial respiratory chain enzymes and mitochondrial cell death proteins. Transgenic mouse models of human neurodegenerative disease are beginning to reveal possible principles governing the biology of selective neuronal vulnerability that implicate mitochondria and the mitochondrial permeability transition pore. This review will present how mitochondrial pathobiology might contribute to neurodegeneration in PD and ALS and could serve as a target for drug therapy.
Martin
Lee J
LJ
Department of Pathology, Division of Neuropathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. martinl@jhmi.edu
D000690:Amyotrophic Lateral Sclerosis / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D000818:Animals; D004272:DNA, Mitochondrial / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D028361:Mitochondrial Diseases / Q000150:complications / Q000235:genetics / Q000473:pathology; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D010300:Parkinson Disease / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D011494:Protein Kinases / Q000235:genetics; D043222:Ubiquitin Thiolesterase / Q000235:genetics; D051844:alpha-Synuclein / Q000235:genetics; D000099202:PTEN-Induced Putative Kinase
D004272:DNA, Mitochondrial; D011494:Protein Kinases; D043222:Ubiquitin Thiolesterase; D051844:alpha-Synuclein; D000099202:PTEN-Induced Putative Kinase; C482860:UCHL1 protein, human