Sustainable synthesis of flavonoid derivatives, QSAR study and insecticidal activity against the fall armyworm, Spodoptera frugiperda (Lep.: Noctuidae).
A simple, clean, solvent-free preparation of flavones by the use of a silica-supported Preyssler heteropolyacid as reusable catalyst is described. High selectivity and very good yields (87-94%) were obtained in short reaction times (7-13 min). Bioassays for insecticidal activity against Spodoptera frugiperda were carried out with a set of flavones. Bioassays showed that some of the flavones had moderate insecticidal activity. Quantitative structure-activity relationships were established on the available data with the purpose of predicting the insecticidal activity of a number of structurally related flavones. A relationship between the molecular structure and biological activity is proposed.
Romanelli
Gustavo P
GP
Cátedra de Química Orgánica, Facultad de Ciencias Agrarias y Forestales, Universidad Nacional de La Plata, Calles 60 y 119, 1904 La Plata, Argentina.
Virla
Eduardo G
EG
Duchowicz
Pablo R
PR
Gaddi
Ana L
AL
Ruiz
Diego M
DM
Bennardi
Daniel O
DO
Del Valle Ortiz
Erlinda
E
Autino
Juan C
JC
D000818:Animals; D002384:Catalysis; D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry; D021281:Quantitative Structure-Activity Relationship; D018411:Spodoptera
D005419:Flavonoids; D007306:Insecticides