Medical and nutrition management of eosinophilic esophagitis in children.
Eosinophilic esophagitis (EoE), esophageal inflammation that occurs in the absence of acidification, is characterized by mucosal eosinophilia and epithelial proliferative changes. Depending on the patient's age, EoE may present as a feeding disorder, vomiting, abdominal pain, dysphagia, or food impaction. In the absence of a well-delineated natural history, case reports suggest that in some individuals with EoE, the disease progresses to esophageal fibrosis and then presumably irreversible esophageal dysfunction. Successful management of EoE in children requires (1) identifying the causative agents for a given patient, (2) implementing effective medical and/or nutrition therapies, and (3) establishing a continuum of long-term care that delivers the child to adulthood without esophageal dysfunction.
Feuling
Mary Beth
MB
Division of Pediatric Gastroenterology and Nutrition, Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. mfeuling@chw.org
Noel
Richard J
RJ
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D002648:Child; D003131:Combined Modality Therapy; D004802:Eosinophilia / Q000150:complications / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D004941:Esophagitis / Q000150:complications / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D005526:Food, Formulated; D006801:Humans; D054328:Proton Pump Inhibitors; D017494:Proton Pumps / Q000627:therapeutic use; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D054328:Proton Pump Inhibitors; D017494:Proton Pumps