Synthesis and characterization of dual modality (CT/MRI) core-shell microparticles for embolization purposes.
Core P(MAOETIB-GMA) microparticles of 40-200 microm were prepared by suspension copolymerization of the iodinated monomer 2-methacryloyloxyethyl (2,3,5-triiodobenzoate), MAOETIB, with a low concentration of the monomer glycidyl methacrylate, GMA, which formed hydrophilic surfaces on the particles. Magnetic gamma-Fe(2)O(3)/P(MAOETIB-GMA) core-shell microparticles were prepared by coating the aforementioned core particles through nucleation of iron oxide nanoparticles on the surfaces of the P(MAOETIB-GMA) particles. This was followed by stepwise growth of thin iron oxide layers. The radiopacity and magnetism of these particles were demonstrated in vitro by CT and MRI. In vivo embolization capabilities of these first multimodal visible embolization particles were demonstrated in a rat's kidney tumor embolization model.
Hagit
Aviv
A
Department of Chemistry, Bar-Ilan University, Ramat-Gan, Israel.
Soenke
Bartling
B
Johannes
Budjan
B
Shlomo
Margel
M
D000818:Animals; D003287:Contrast Media / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004621:Embolization, Therapeutic; D004852:Epoxy Compounds / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D008297:Male; D008689:Methacrylates / Q000737:chemistry*; D010316:Particle Size; D011109:Polymethacrylic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012077:Renal Artery / Q000000981:diagnostic imaging; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014057:Tomography, X-Ray Computed; D014283:Triiodobenzoic Acids / Q000737:chemistry*
D003287:Contrast Media; D004852:Epoxy Compounds; D005290:Ferric Compounds; D008689:Methacrylates; D011109:Polymethacrylic Acids; D014283:Triiodobenzoic Acids; C104156:2-(2',3',5'-triiodobenzoyl)ethyl methacrylate; C000499:ferric oxide; C007870:glycidyl methacrylate