[Expression and relationship of EBV LMP1, COX-2 and VEGF-C in nasopharyngeal carcinoma].
OBJECTIVE
To evaluate the expression of vascular endothelial growth factor C (VEGF-C), Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1), cyclooxygenase-2 (COX-2) in nasopharyngeal carcinoma (NPC).


METHODS
LMP1, COX-2 and VEGF-C were detects by immunohistochemical staining for 57 case NPC tissue.


RESULTS
The positives rates of LMP1, COX-2 and VEGF-C detected by immunohistochemical staining were 49.1% (28/57), 75.4% (43/57) and 59.6% (34/57), respectively. The expression of LMP1, COX-2 and VEGF-C were correlated to each other in NPC (P < 0.05).


CONCLUSIONS
LMP1 and COX-2 may induce expression of VEGF-C directly or LMP1 induce expression of VEGF-C by induce COX-2 expression, may contribute to lymph metastasis and develop NPC.
Yi
Xiang
X
Department of Otorhinolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, Nanjing, 530021, China.
Tang
Anzhou
A
Qin
Ying
Y
Wen
Wensheng
W
Zhao
Weimin
W
D000328:Adult; D000368:Aged; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D009367:Neoplasm Staging; D042582:Vascular Endothelial Growth Factor C / Q000378:metabolism*; D014763:Viral Matrix Proteins / Q000378:metabolism*; D055815:Young Adult
C037662:EBV-associated membrane antigen, Epstein-Barr virus; C467486:VEGFC protein, human; D042582:Vascular Endothelial Growth Factor C; D014763:Viral Matrix Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human