BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia.
Brain-derived neurotrophic factor (BDNF) gene variants may potentially influence behaviour. In order to test this hypothesis, we investigated the relationship between BDNF Val66Met polymorphism and aggressive behaviour in a population of schizophrenic patients. Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour.
Spalletta
G
G
IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardetina, 306, 00179 Rome, Italy.
Morris
D W
DW
Angelucci
F
F
Rubino
I A
IA
Spoletini
I
I
Bria
P
P
Martinotti
G
G
Siracusano
A
A
Bonaviri
G
G
Bernardini
S
S
Caltagirone
C
C
Bossù
P
P
Donohoe
G
G
Gill
M
M
Corvin
A P
AP
D000328:Adult; D000374:Aggression / Q000523:psychology*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008715:Methionine; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D014633:Valine
D019208:Brain-Derived Neurotrophic Factor; D008715:Methionine; D014633:Valine