99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: induction and control of regulatory T cells in the gastrointestinal tract: consequences for local and peripheral immune responses.
Regulatory T cells play a crucial role in normal gut homeostasis, as well as during infection with microbial or parasitic pathogens. Prior to infection, interactions with the commensal microflora are essential to differentiation of a healthy steady-state level of immunoregulation, mediated through both Toll-like receptor-dependent and -independent pathways. The ingress of pathogenic organisms may, according to the context, promote or reverse the regulatory environment, with onward consequences for inflammation in both the intestinal and extra-intestinal settings. Appropriate regulation of gut immunity thus depends upon a complex three-way interplay between host cells, commensals and pathogens, and can exert a major impact on systemic responses including allergy and autoimmunity.
Belkaid
Y
Y
NIAID, National Institutes of Health, Laboratory of Parasitic Diseases, Bethesda, MD, USA.
Liesenfeld
O
O
Maizels
R M
RM
D001327:Autoimmune Diseases / Q000276:immunology / Q000382:microbiology; D002908:Chronic Disease; D003141:Communicable Diseases / Q000276:immunology*; D006706:Homeostasis / Q000276:immunology; D006790:Host-Parasite Interactions / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D007422:Intestines / Q000276:immunology* / Q000382:microbiology; D010272:Parasitic Diseases / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology
D051193:Toll-Like Receptors