Anterior vaginal wall prolapse: a randomized controlled trial of SIS graft versus traditional colporrhaphy.
OBJECTIVE
This study seeks to compare the small intestine submucosa (SIS) graft with traditional colporrhaphy (TC) for surgical treatment of anterior vaginal prolapse.


METHODS
Subjects were randomly assigned to SIS (n = 29) or to TC (n = 27) preoperatively and outcomes analyzed at 12 months postoperatively. The primary outcome was the absence of POP-Q stage >or= II prolapse, and secondary outcome was improvement in quality of life. Data were compared with independent samples or paired Student's t test.


RESULTS
SIS group had 86.2% anatomic cure compared to 59.3% in TC (p = 0.03). SIS improved point Ba measurement significantly (-1.93 cm versus -1.37 cm, p = 0.02). Both operations significantly improved quality of life, although there were no differences between the groups. We observed a greater number of complications in the SIS group, with no infections or erosion.


CONCLUSIONS
SIS repair improved point Ba significantly. However, there were no differences observed in quality of life between the techniques.
Feldner
Paulo Cezar
PC
Section of Urogynecology and Pelvic Surgery, Department of Gynecology, Universidade Federal de São Paulo, Rua dos Otonis, 601 (Vila Clementino), 04025-001, São Paulo, SP, Brazil. pfeldner@alfa.epm.br
Castro
Rodrigo Aquino
RA
Cipolotti
Luiz Antonio
LA
Delroy
Carlos Antonio
CA
Sartori
Marair Gracio Ferreira
MG
Girão
Manoel João Batista Castello
MJ
D020884:Colpotomy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007413:Intestinal Mucosa / Q000637:transplantation*; D008875:Middle Aged; D011788:Quality of Life; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014596:Uterine Prolapse / Q000601:surgery*