title: Relationship between nocturnal blood pressure variation and silent cerebral infarction in Chinese hypertensive patients.
abstract: BACKGROUND
  To investigate the relationship between nocturnal blood pressure (BP) variation and silent cerebral infarction (SCI) in hypertensive patients.
  
  
  METHODS
  We retrospectively collected demographic, clinical, and laboratory data from 188 Chinese hypertensive patients (111 with SCI, 77 with non-SCI) and analyzed nocturnal BP variation in the SCI and non-SCI patients. Multiple logistic regression was used for analysis.
  
  
  RESULTS
  We found that both single and multiple SCI were more common in nondipping patients than dipping patients. In further analysis comparing the SCI group with the non-SCI group, we found that carotid artery plaques and duration of hypertension were independent risk factors of SCI (p<0.05). The nocturnal BP fall (r=-10.614, p=0.000) was also found to be negatively correlated with SCI in our study. In addition, the prevalence of nondipping was not different between the users of three different classes of antihypertensive drugs.
  
  
  CONCLUSIONS
  Our ambulatory blood pressure monitoring study suggested that nondipping was associated with both single and multiple SCI. Abnormal circadian blood pressure rhythm, a parameter in evaluating injury of brain blood vessels, might be a risk factor of SCI.
authors.affiliation: Department of Neurology & Institute of Neurology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200025, China.
authors.forename: J F
authors.initials: JF
authors.lastname: Ma
authors.forename: J L
authors.initials: JL
authors.lastname: Sun
authors.forename: J
authors.initials: J
authors.lastname: Zhao
authors.forename: X
authors.initials: X
authors.lastname: Wei
authors.forename: B S
authors.initials: BS
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Fu
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D020520:Brain Infarction / Q000097:blood / Q000503:physiopathology*; D002339:Carotid Arteries / Q000473:pathology; D002340:Carotid Artery Diseases / Q000097:blood / Q000503:physiopathology; D002681:China; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D017440:Photoperiod; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors
chemical_list: D000959:Antihypertensive Agents