title: Fas and FasL polymorphisms are not associated with acute myeloid leukemia risk in Koreans.
abstract: Fas and Fas ligand (FasL) polymorphisms in the promoter regions influence transcriptional activities. The interaction of these two genes plays a crucial role in apoptotic cell death regulation. They have been associated with esophageal, lung, uterine cervical, and urinary bladder cancers in human. We performed a case-control study to investigate the association between Fas and FasL polymorphisms and acute myeloid leukemia (AML) risk. Fas−1377G>A (rs2234767), −670T>C (rs1800682), and FasL−844T>C (rs763110) polymorphisms in 592 AML patients and 858 healthy controls were genotyped and tested for associations between polymorphisms and AML risk. There were no significant differences in genotypic and haplotypic distributions and gene-gene interaction between patients and controls in the overall analysis (p>0.05). These results suggested that polymorphisms of Fas and FasL genes were not associated with AML risk in the Korean population.
authors.affiliation: Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun-gun, Chonnam, Republic of Korea.
authors.forename: Hyun Jeong
authors.initials: HJ
authors.lastname: Kim
authors.forename: Xue Mei
authors.initials: XM
authors.lastname: Jin
authors.forename: Hee-Nam
authors.initials: HN
authors.lastname: Kim
authors.forename: Il-Kwon
authors.initials: IK
authors.lastname: Lee
authors.forename: Kyeong-Soo
authors.initials: KS
authors.lastname: Park
authors.forename: Moo Rim
authors.initials: MR
authors.lastname: Park
authors.forename: Deog Yeon
authors.initials: DY
authors.lastname: Jo
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Won
authors.forename: Jae-Yong
authors.initials: JY
authors.lastname: Kwak
authors.forename: Hyeoung-Joon
authors.initials: HJ
authors.lastname: Kim
authors.forename: Jin-Su
authors.initials: JS
authors.lastname: Choi
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Juhng
authors.forename: Chan
authors.initials: C
authors.lastname: Choi
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D053222:Fas Ligand Protein / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk; D019014:fas Receptor / Q000235:genetics*
chemical_list: D053222:Fas Ligand Protein; D019014:fas Receptor