Adenosine A2A receptor expression in peripheral blood mononuclear cells of patients with mild cognitive impairment.
Adenosine suppresses immune responses through the adenosine A2A receptors (A2AR). We evaluated the expression of A2AR in blood mononuclear cells (PBMCs) of patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and controls in order to verify if it may help distinguish different forms of cognitive decline. There was a significant linear increase in both mRNA levels and receptor density from multiple cognitive domain MCI (mcd-MCI) to amnestic MCI (a-MCI), spanning through AD and controls, without any significant difference between the latter two groups of subjects. These data, which need to be confirmed in a larger number of patients, suggest that expression of A2AR in PBMCs may be a valuable means of differentiating a-MCI and mcd-MCI.
Arosio
Beatrice
B
Department of Internal Medicine, Università degli Studi di Milano, Geriatric Unit, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milano, Italy. beatrice.arosio@unimi.it
Viazzoli
Chiara
C
Mastronardi
Luigina
L
Bilotta
Claudio
C
Vergani
Carlo
C
Bergamaschini
Luigi
L
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D000647:Amnesia / Q000235:genetics / Q000523:psychology; D001057:Apolipoproteins E / Q000235:genetics; D003072:Cognition Disorders / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D018076:DNA, Complementary / Q000235:genetics; D005260:Female; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008297:Male; D009000:Monocytes / Q000378:metabolism*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D043705:Receptor, Adenosine A2A / Q000096:biosynthesis* / Q000097:blood / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction
D001057:Apolipoproteins E; D018076:DNA, Complementary; D012333:RNA, Messenger; D043705:Receptor, Adenosine A2A