title: Endoscopic ultrasound-guided fine-needle aspiration cytology in the evaluation of suspected tuberculosis in patients with isolated mediastinal lymphadenopathy.
abstract: OBJECTIVE
  Patients with suspected tuberculosis without pulmonary lesions and with mediastinal lymphadenopathy often pose a diagnostic challenge. Endoscopic ultrasound (EUS)-guided fine-needle aspiration (FNA) cytology is an established modality to evaluate mediastinal and abdominal lesions. The aim of the present study was to evaluate the role of EUS-FNA in isolated mediastinal lymphadenopathy in patients suspected of having tuberculosis.
  
  
  METHODS
  Consecutive patients suspected of having tuberculosis with isolated mediastinal lymphadenopathy were included in a prospective study. Mediastinal lymphadenopathy was diagnosed on a contrast-enhanced computed tomography scan of the chest. Patients with concomitant lung parenchymal lesions were excluded. Previous attempts to diagnose the etiology of lymphadenopathy had failed in 69 % of patients. EUS-FNA was performed on an outpatient basis under conscious sedation. The sensitivity, specificity, and diagnostic accuracy of EUS-FNA were calculated.
  
  
  RESULTS
  A total of 60 consecutive patients (mean age 39.8 years, 58 % males) with mediastinal lymphadenopathy were included. EUS confirmed the presence of mediastinal lymph nodes ranging in size from 8 mm to 40 mm (mean 26 mm) in all patients. EUS-FNA provided an adequate tissue sample in 54 patients during the first examination and repeat EUS-FNA was necessary in six patients. A final diagnosis was obtained by EUS-FNA in 42 patients (tuberculosis in 32, sarcoidosis in six, and Hodgkin's disease in four patients). An additional 14 patients were treated for tuberculosis based on EUS-FNA and clinical features. Mediastinoscopy was required for diagnosis in the remaining four patients. EUS-FNA had an overall diagnostic yield of 93 %, sensitivity of 71 %, specificity of 100 %, and positive predictive value of 100 %.
  
  
  CONCLUSIONS
  EUS-FNA is an accurate, safe, and minimally invasive modality for evaluating isolated mediastinal lymphadenopathy in patients suspected of having tuberculosis in an endemic area with a high prevalence of tuberculosis.
authors.affiliation: Department of Gastroenterology, Sir Ganga Ram Hospital, New Delhi, India. purirajesh69@gmail.com
authors.forename: R
authors.initials: R
authors.lastname: Puri
authors.forename: P
authors.initials: P
authors.lastname: Vilmann
authors.forename: R
authors.initials: R
authors.lastname: Sud
authors.forename: M
authors.initials: M
authors.lastname: Kumar
authors.forename: S
authors.initials: S
authors.lastname: Taneja
authors.forename: K
authors.initials: K
authors.lastname: Verma
authors.forename: N
authors.initials: N
authors.lastname: Kaushik
mesh_terms: D000328:Adult; D044963:Biopsy, Fine-Needle; D019160:Endosonography; D005260:Female; D006689:Hodgkin Disease; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology*; D008206:Lymphatic Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008481:Mediastinoscopy; D008482:Mediastinum; D011446:Prospective Studies; D012507:Sarcoidosis; D012680:Sensitivity and Specificity; D014376:Tuberculosis / Q000000981:diagnostic imaging / Q000473:pathology*