Expression of sarcolectin in the human pituitary gland and amniotic fluid.
Sarcolectin (SCL) is a 55 kDa protein cross-reacting with a cytokeratin 7 monomer found in placental blood, sarcomas and various tissues. It blocks the synthesis of interferon-dependent secondary proteins, induces cell DNA activation and sensitizes cells to viral infection. SCL is a potent promoter of tissue growth. In the present report, we demonstrate that SCL is expressed in the human pituitary gland at the mRNA and protein levels. We show also its presence in human amniotic fluid in high titres while interferon titres is weak. These results allow to postulate a potential role of SCL as a growth factor participating in human foetal development.
M'bika
Jean-Pierre
JP
Laboratoire des Interférons et de la Sarcolectine, Université Paris Descartes, Centre Universitaire des Saints-Pères, Paris, France.
Khazen
Wael
W
Achour
Ammar
A
Chany
Charles
C
D000368:Aged; D000369:Aged, 80 and over; D000653:Amniotic Fluid / Q000378:metabolism*; D001483:Base Sequence; D015153:Blotting, Western; D017931:DNA Primers; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D037102:Lectins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000378:metabolism*; D016133:Polymerase Chain Reaction
D017931:DNA Primers; D037102:Lectins; C039495:sarcolectin