Transient IgA nephropathy with acute kidney injury in a patient with dengue fever.
Dengue virus infection can clinically manifest as dengue fever, dengue shock syndrome and dengue hemorrhagic fever. Acute kidney injury as a result of dengue virus infection can occur due to various reasons including hypotension, rhabdomyolysis, sepsis and rarely immune complex mediated glomerular injury. However, glomerulonephritis associated with IgA Nephropathy in dengue virus infection has not been reported previously. We report a case of 15-year-old boy who was admitted with dengue fever and dialysis dependant acute kidney injury. Urine examination showed microscopic glomerular hematuria and proteinuria. Kidney biopsy showed mesangial proliferation with mesangial IgA dominant immune complex deposits and acute tubular necrosis. A repeated kidney biopsy 6 weeks after clinical recovery showed reversal of glomerular changes as well as resolution of mesangial IgA deposits.
Upadhaya
Bala Krishna
BK
Department of Nephrology, All India Institute of Medical Sciences, New Delhi, India.
Sharma
Alok
A
Khaira
Ambar
A
Dinda
Amit K
AK
Agarwal
Sanjay K
SK
Tiwari
Suresh C
SC
D000208:Acute Disease; D000293:Adolescent; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001706:Biopsy; D003715:Dengue / Q000150:complications* / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D005455:Fluorescent Antibody Technique; D005922:Glomerulonephritis, IGA / Q000175:diagnosis / Q000276:immunology / Q000628:therapy / Q000821:virology*; D015432:Glomerulonephritis, Membranoproliferative / Q000175:diagnosis / Q000276:immunology / Q000628:therapy / Q000821:virology*; D006417:Hematuria / Q000821:virology; D006801:Humans; D007673:Kidney Cortex Necrosis / Q000175:diagnosis / Q000276:immunology / Q000628:therapy / Q000821:virology*; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D011507:Proteinuria / Q000821:virology; D006435:Renal Dialysis; D016896:Treatment Outcome; D014556:Urine / Q000737:chemistry / Q000166:cytology
D000890:Anti-Infective Agents