Hyperoxia-derived lung damage in preterm infants.
Hyperoxia-induced lung injury is characterized by an influx of inflammatory cells, increased pulmonary permeability, endothelial and epithelial cell death. This review highlights the mechanistic aspects of inflammation, vascular leak and cell death. The focus will be on agents that contribute to hyperoxia-induced lung injury in developmentally appropriate animal models, and those that have been detected in human premature neonates.
Bhandari
Vineet
V
Division of Perinatal Medicine, Yale University School of Medicine, Department of Pediatrics, New Haven, CT 06520-8064, USA. vineet.bhandari@yale.edu
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D018496:Hyperoxia / Q000378:metabolism / Q000473:pathology*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000378:metabolism*; D055370:Lung Injury / Q000378:metabolism / Q000473:pathology*