Hepatic artery resistance in children with obesity and fatty liver.
OBJECTIVE
The present study assessed whether there is a correlation between hepatic artery resistive index (HARI) and increase of body mass index and hepatosteatosis grading in children with non-alcoholic fatty liver disease (NAFLD) reflecting hemodynamic effects of hepatosteatosis.


METHODS
Thirty three healthy children [body mass index(BMI): mean+/- standart deviation(SD), min-max: 20.1+/-1.14(18.5-23.7), 33 overweight [BMI:25.1+/-2.2 (18.5-23.7)] and 66 obese [BMI:31.1+/-2(25.6-40)] adolescents were enrolled into the study. To search the relation of HARI with fatty liver degree, study subjects subdivided into groups according to their degree of fatty liver at ultrasonography(US).


RESULTS
Increase of HARI was correlated with increase in BMI (p<0.0001, r=0.533). Increase of HARI was well correlated with increase in degree of fatty liver (p<0.0001, r=0.630).


CONCLUSIONS
The present study results suggest that there are positive correlations of HARI with BMI and hepatosteatosis grade in obese children with NAFLD. HARI may be a candidate parameter to determine early alarming hemodynamic changes in hepatic tissue of obese children with fatty liver before development of severe stages NAFLD.
Hizli
Samil
S
MH Ankara Keçiören Research and Training Hospital, Pediatric Gastroenterology, Hepatology and Nutrition Clinic Ankara, Dokuz Eylül University, Faculty of Medicine, Izmir, Turkey. shizli@yahoo.com
Koçyigit
A
A
Arslan
N
N
Tuncel
S A
SA
Demircioglu
F
F
Cakmakçi
H
H
Büyükgebiz
B
B
D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D005234:Fatty Liver / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006499:Hepatic Artery / Q000503:physiopathology*; D006801:Humans; D008297:Male; D009765:Obesity / Q000150:complications / Q000503:physiopathology*; D018608:Ultrasonography, Doppler; D014655:Vascular Resistance