The association between metabolic syndrome and infarct size in patients with acute myocardial infarction.
BACKGROUND
In patients with the metabolic syndrome, the prevalence of cardiovascular disease, disease-related morbidity and mortality are reported to be significantly higher than in a population without the metabolic syndrome. We investigated the role of metabolic syndrome and related biomarkers as predictors of infarct size in patients with their first myocardial infarction.


METHODS
This was a cross-sectional sub-study from the 3 months follow-up in the NORwegian Study of DIstrict treatment of ST-Elevation Myocardial Infarction (NORDISTEMI), including 152 consecutive patients, all initially treated with thrombolysis. Infarct size after 3 months was determined by late gadolinium enhanced magnetic resonance imaging, measuring ventricular infarct volume in absolute and relative terms.


RESULTS
At 3 months, 33 patients (22%) were categorized as having metabolic syndrome. There was no significant difference in median infarct size between those presenting with and without the metabolic syndrome [relative infarct volume 9.0 (4.8, 15.1) % vs. 8.3 (2.9, 13.6)%, p = 0.34]. Adjusting for possible confounders did not alter the results essentially. Circulating levels of IL-18, CRP and PAI-I activity were significantly higher in patients with the metabolic syndrome while adiponectin concentrations were significantly lower (p < or = 0.01 for all). None of these variables were associated with myocardial infarct size.


CONCLUSIONS
No association between the presence of metabolic syndrome and related biomarkers, and the size of the myocardial infarction was apparent in this study population.
Bøhmer
Ellen
E
Oslo University Hospital, Ulleval, Department of Cardiology, Oslo, Norway. ellen.bohmer@sykehuset-innlandet.no
Seljeflot
Ingebjørg
I
Arnesen
Harald
H
Hoffmann
Pavel
P
Abdelnoor
Michael
M
Halvorsen
Sigrun
S
D052242:Adiponectin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications* / Q000473:pathology; D012720:Severity of Illness Index
D052242:Adiponectin; D015415:Biomarkers; D020382:Interleukin-18