Effects of biliary and pancreatic juice diversion into the ileum on gastrointestinal motility and gut hormone secretion in conscious dogs.
BACKGROUND
The aim of the present study was to investigate the effects of diversion of biliary and pancreatic juices on upper gut motility and hormone secretion.


METHODS
We used dogs equipped with strain gauge force transducers to measure upper gut motility. Dogs were divided into 5 groups: control, sham operation, biliary diversion (BD), pancreatic juice diversion (PJD), and biliopancreatic juice diversion (BPD). Postprandial plasma concentrations of insulin, gastric inhibitory polypeptide (GIP), and peptide YY (PYY) were also measured.


RESULTS
Occurrence and migration velocity of the migrating motor complex in the jejunum in the interdigestive state were decreased in the BD and BPD groups compared with the other 3 groups (P < .05). In the BD and BPD groups, areas of postprandial contractile curves in the upper gut were decreased, and the duration of the postprandial contractions in the proximal jejunum, which a previous study showed to correlate with gastric emptying, were less compared with the other 3 groups (P < .05). Plasma insulin levels did not differ among the 5 groups. Plasma concentrations of GIP suppressed in the PJD and BPD groups (P < .05), whereas plasma PYY level was increased in the BD group (P < .05).


CONCLUSIONS
Bile diversion seems to inhibit interdigestive and postprandial upper gut contractions in association with an increase of plasma PYY. Pancreatic juice was considered to play a role in the secretion of GIP.
Sato
Manabu
M
Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shibata
Chikashi
C
Kikuchi
Daisuke
D
Ikezawa
Fumie
F
Imoto
Hirofumi
H
Sasaki
Iwao
I
D000818:Animals; D001646:Bile / Q000502:physiology*; D001786:Blood Glucose / Q000032:analysis; D004285:Dogs; D005749:Gastric Inhibitory Polypeptide / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D005769:Gastrointestinal Motility; D007082:Ileum / Q000502:physiology*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D010189:Pancreatic Juice / Q000502:physiology*; D019894:Peptide YY / Q000378:metabolism
D001786:Blood Glucose; D005768:Gastrointestinal Hormones; D007328:Insulin; D019894:Peptide YY; D005749:Gastric Inhibitory Polypeptide