title: [Malignant pilomatrixoma of head and neck. A case report].
abstract: We report the case of a 66-year-old patient with a pilomatrix carcinoma from the right submandibular region with pulmonary and cerebral metastases. The histological confirmation of the diagnosis has been based on the biopsy of the submandibular tumefaction which was rapidly growing. We tried at first a doxorubicine and cisplatine chemotherapy because of the considerable locoregional extension and the existence of pulmonary metastases. The patient response to three cures of chemotherapy was spectacular with a partial clinical response (75%) and a partially cleaned-up chest observed in the radiological evaluation. In the 5th cycle of chemotherapy following the same protocol, the patient presented a relapse with cerebral metastases. The patient received hypofractionated radiotherapy on the brain followed by etoposide and cisplatine chemotherapy, then oral vinorelbine. The patient died of progressive disease after 32 weeks.
authors.affiliation: CHU Ibn Rochd, quartier des Hôpitaux, Casablanca, Maroc. tawfiqnezha@yahoo.fr <tawfiqnezha@yahoo.fr>
authors.forename: N
authors.initials: N
authors.lastname: Tawfiq
authors.forename: N
authors.initials: N
authors.lastname: Lakhrib
authors.forename: A
authors.initials: A
authors.lastname: Mharech
authors.forename: N
authors.initials: N
authors.lastname: Benchakroun
authors.forename: A
authors.initials: A
authors.lastname: Benider
authors.forename: A
authors.initials: A
authors.lastname: Benkirane
authors.forename: S
authors.initials: S
authors.lastname: Zamiati
authors.forename: I
authors.initials: I
authors.lastname: Mansouri
authors.forename: M
authors.initials: M
authors.lastname: Roubal
authors.forename: M E
authors.initials: ME
authors.lastname: Kadiri Fatmi
authors.forename: N
authors.initials: N
authors.lastname: Elbenna
authors.forename: A
authors.initials: A
authors.lastname: Abdelouafi
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005153:Facial Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000556:secondary; D008297:Male; D018296:Pilomatrixoma / Q000175:diagnosis / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D012878:Skin Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D000077235:Vinorelbine
chemical_list: D014747:Vinblastine; D005047:Etoposide; D004317:Doxorubicin; D002945:Cisplatin; D000077235:Vinorelbine