title: [Improvement of natural resistance in children for prophylaxis of influenza and acute respiratory tract viral infections (results of multicenter randomized trials)].
abstract: The results of the multicentre clinical trials on cycloferon efficacy in children at the age from 4 to 16 years are presented. The prophylactic effect of the drug (2.9-7.2-fold decrease of the morbidity) with respect to the respiratory tract mono- and mixed infections was showen. The marked cytoprotective effect, evident from lower destruction of the epithelial cells and increased activity of the local nonspecific resistance factors (lysozyme, secretory immunoglobulin A) was observed.
authors.forename: M G
authors.initials: MG
authors.lastname: Romantsov
authors.forename: E P
authors.initials: EP
authors.lastname: Sel'kova
authors.forename: M V
authors.initials: MV
authors.lastname: Garashchenko
authors.forename: T A
authors.initials: TA
authors.lastname: Semenenko
authors.forename: A A
authors.initials: AA
authors.lastname: Shul'diakov
authors.forename: E I
authors.initials: EI
authors.lastname: Kondrat'eva
authors.forename: E Iu
authors.initials: EIu
authors.lastname: Tiuteva
authors.forename: A L
authors.initials: AL
authors.lastname: Kovalenko
mesh_terms: D000166:Acridines / Q000627:therapeutic use*; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007251:Influenza, Human / Q000517:prevention & control*; D007369:Interferon Inducers / Q000627:therapeutic use*; D012141:Respiratory Tract Infections / Q000517:prevention & control*
chemical_list: D000166:Acridines; D007369:Interferon Inducers; C026430:10-carboxymethyl-9-acridanone