Synthesis of a glycosylphosphatidylinositol anchor bearing unsaturated lipid chains.
A GPI anchor bearing unsaturated fatty acid lipid chains (1) was synthesized by a highly convergent strategy employing the para-methoxybenzyl group for permanent hydroxyl protection. The final global deprotection was achieved by an efficient three-step, one-pot procedure to give an 81% isolated yield of the target structure.
Swarts
Benjamin M
BM
Department of Chemistry, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202, USA.
Guo
Zhongwu
Z
D000840:Anisoles / Q000737:chemistry; D005231:Fatty Acids, Unsaturated / Q000737:chemistry*; D005240:Feasibility Studies; D017261:Glycosylphosphatidylinositols / Q000138:chemical synthesis* / Q000737:chemistry*; D006878:Hydroxides / Q000737:chemistry
D000840:Anisoles; D005231:Fatty Acids, Unsaturated; D017261:Glycosylphosphatidylinositols; D006878:Hydroxides; C031356:hydroxide ion; C060998:anisole