Elastic vesicles of sumatriptan succinate for transdermal administration: characterization and in vitro permeation studies.
Elastic liposomes, including sumatriptan succinate, were prepared for their transdermal administration. Lipid vesicles containing 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) or l-α-phosphatidylcholine dilauroyl (DLPC) phospholipids were characterized for various parameters, including size, particle-size distribution (i.e., polydispersity index), and elasticity. In vitro transdermal experiments for the study of the skin penetration of sumatriptan succinate contained in liposomes were performed by using flow-through diffusion cells. The diameter of sumatriptan liposomes with different lipid compositions varied between 279 and 282 nm, and the polydispersity index value for the size distribution of liposomal formulations was <0.5. DLPC vesicles proved to be more elastic and provided a higher sumatriptan transdermal flux than vesicles formulated with DOPC phospolipid.
Balaguer-Fernández
Cristina
C
Departamento de Fisiología, Farmacología y Toxicología, Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, Moncada, Spain. cbalaguer@uch.ceu.es
Femenía-Font
Andres
A
Merino
Virginia
V
Córdoba-Díaz
Damián
D
Elorza-Barroeta
María A
MA
López-Castellano
Alicia
A
Córdoba-Díaz
Manuel
M
D000279:Administration, Cutaneous; D000818:Animals; D004548:Elasticity; D066298:In Vitro Techniques; D008081:Liposomes; D010316:Particle Size; D010539:Permeability; D012867:Skin / Q000378:metabolism; D018170:Sumatriptan / Q000008:administration & dosage*; D013552:Swine
D008081:Liposomes; D018170:Sumatriptan