title: A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity.
abstract: A library of 4,5-disubstituted-2-aminoimidazoles was synthesized using a nitroenolate route and then screened for antibiofilm and antimicrobial activity. These compounds displayed notable biofilm dispersal and planktonic microbicidal activity against various Gram-positive and Gram-negative bacteria.
authors.affiliation: Department of Chemistry, North Carolina State University, Raleigh, USA.
authors.forename: Zhaoming
authors.initials: Z
authors.lastname: Su
authors.forename: Steven A
authors.initials: SA
authors.lastname: Rogers
authors.forename: W Steve
authors.initials: WS
authors.lastname: McCall
authors.forename: Alicia C
authors.initials: AC
authors.lastname: Smith
authors.forename: Sindhu
authors.initials: S
authors.lastname: Ravishankar
authors.forename: Trey
authors.initials: T
authors.lastname: Mullikin
authors.forename: Christian
authors.initials: C
authors.lastname: Melander
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018441:Biofilms; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000502:physiology; D007093:Imidazoles / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D007093:Imidazoles; C014973:2-aminoimidazole