Development of a recombinant epsilon toxoid vaccine against enterotoxemia and its use as a combination vaccine with live attenuated sheep pox virus against enterotoxemia and sheep pox.
Sheep pox and enterotoxemia are important diseases of sheep, and these diseases cause severe economic losses to sheep farmers. The present study was undertaken to evaluate the potential of formaldehyde-inactivated recombinant epsilon toxin as a vaccine candidate. The potency of the recombinant epsilon toxoid with aluminum hydroxide as an adjuvant in sheep was determined. Vaccinated sheep were protected against enterotoxemia, with potency values of >5 IU being protective. Further, the use of this construct in a combination vaccine against sheep pox resulted in the sheep being protected against both sheep pox and enterotoxemia.
Chandran
Dev
D
Indian Immunologicals Limited, Rakshapuram, Gachibowli, Hyderabad 500032, India.
Naidu
Sureddi Satyam
SS
Sugumar
Parthasarathy
P
Rani
Gudavalli Sudha
GS
Vijayan
Shahana Pallichera
SP
Mathur
Deepika
D
Garg
Lalit C
LC
Srinivasan
Villuppanoor Alwar
VA
D000818:Animals; D001427:Bacterial Toxins / Q000235:genetics / Q000276:immunology*; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D018151:Capripoxvirus / Q000276:immunology*; D004767:Enterotoxemia / Q000276:immunology / Q000517:prevention & control*; D005557:Formaldehyde / Q000494:pharmacology; D011213:Poxviridae Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary* / Q000821:virology; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control* / Q000821:virology; D014121:Toxoids / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000276:immunology; D017778:Vaccines, Combined; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology
D001427:Bacterial Toxins; D001428:Bacterial Vaccines; C039811:Clostridium perfringens epsilon-toxin; D014121:Toxoids; D014613:Vaccines, Attenuated; D017778:Vaccines, Combined; D014614:Vaccines, Synthetic; D014765:Viral Vaccines; D005557:Formaldehyde