title: The nutrition-based comprehensive intervention study on childhood obesity in China (NISCOC): a randomised cluster controlled trial.
abstract: BACKGROUND
  Childhood obesity and its related metabolic and psychological abnormalities are becoming serious health problems in China. Effective, feasible and practical interventions should be developed in order to prevent the childhood obesity and its related early onset of clinical cardiovascular diseases. The objective of this paper is to describe the design of a multi-centred random controlled school-based clinical intervention for childhood obesity in China. The secondary objective is to compare the cost-effectiveness of the comprehensive intervention strategy with two other interventions, one only focuses on nutrition education, the other only focuses on physical activity.
  
  
  METHODS
  The study is designed as a multi-centred randomised controlled trial, which included 6 centres located in Beijing, Shanghai, Chongqing, Shandong province, Heilongjiang province and Guangdong province. Both nutrition education (special developed carton style nutrition education handbook) and physical activity intervention (Happy 10 program) will be applied in all intervention schools of 5 cities except Beijing. In Beijing, nutrition education intervention will be applied in 3 schools and physical activity intervention among another 3 schools. A total of 9750 primary students (grade 1 to grade 5, aged 7-13 years) will participate in baseline and intervention measurements, including weight, height, waist circumference, body composition (bioelectrical impendence device), physical fitness, 3 days dietary record, physical activity questionnaire, blood pressure, plasma glucose and plasma lipid profiles. Data concerning investments will be collected in our study, including costs in staff training, intervention materials, teachers and school input and supervising related expenditure.
  
  
  CONCLUSIONS
  Present study is the first and biggest multi-center comprehensive childhood obesity intervention study in China. Should the study produce comprehensive results, the intervention strategies would justify a national school-based program to prevent childhood obesity in China.
authors.affiliation: National Institute For Nutrition And Food Safety, Chinese Center For Disease Control And Prevention, Beijing, China. liyanping72@yahoo.com
authors.forename: Yanping
authors.initials: Y
authors.lastname: Li
authors.forename: Xiaoqi
authors.initials: X
authors.lastname: Hu
authors.forename: Qian
authors.initials: Q
authors.lastname: Zhang
authors.forename: Ailing
authors.initials: A
authors.lastname: Liu
authors.forename: Hongyun
authors.initials: H
authors.lastname: Fang
authors.forename: Linan
authors.initials: L
authors.lastname: Hao
authors.forename: Yifan
authors.initials: Y
authors.lastname: Duan
authors.forename: Haiquan
authors.initials: H
authors.lastname: Xu
authors.forename: Xianwen
authors.initials: X
authors.lastname: Shang
authors.forename: Jun
authors.initials: J
authors.lastname: Ma
authors.forename: Guifa
authors.initials: G
authors.lastname: Xu
authors.forename: Lin
authors.initials: L
authors.lastname: Du
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Hongwei
authors.initials: H
authors.lastname: Guo
authors.forename: Tingyu
authors.initials: T
authors.lastname: Li
authors.forename: Guansheng
authors.initials: G
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure; D002648:Child; D002681:China; D003362:Cost-Benefit Analysis; D015930:Diet Records; D015444:Exercise; D005247:Feeding Behavior; D005260:Female; D006266:Health Education; D006801:Humans; D008055:Lipids / Q000097:blood; D009765:Obesity / Q000378:metabolism / Q000517:prevention & control*; D010809:Physical Fitness; D015995:Prevalence; D012572:School Health Services / Q000191:economics
chemical_list: D001786:Blood Glucose; D008055:Lipids