title: Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus.
abstract: Patients with systemic lupus erythematosus (SLE) often suffer from depression and fatigue in addition to the physical manifestations of the autoimmune disease. Elevated production of type-I interferons (IFN-I) has been found in lupus patients and IFN-I can precipitate a variety of neuropsychiatric side effects. This study was conducted to evaluate the relationship between dysregulated IFN-I production and the presence of depression or fatigue in lupus patients. Through cross-sectional and longitudinal analysis we found no significant correlation between abnormal IFN-I levels (as measured by peripheral blood expression of IFN-I-stimulated genes) and neuropsychiatric manifestations. Elevation of endogenous serum IFN-I levels is unlikely to account for the depression and fatigue associated with SLE.
authors.affiliation: Division of Rheumatology & Clinical Immunology, University of Florida, Gainesville, FL 32610-0221, USA.
authors.forename: Erinn S
authors.initials: ES
authors.lastname: Kellner
authors.forename: Pui Y
authors.initials: PY
authors.lastname: Lee
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Juliana
authors.initials: J
authors.lastname: Switanek
authors.forename: Haoyang
authors.initials: H
authors.lastname: Zhuang
authors.forename: Mark S
authors.initials: MS
authors.lastname: Segal
authors.forename: Eric S
authors.initials: ES
authors.lastname: Sobel
authors.forename: Minoru
authors.initials: M
authors.lastname: Satoh
authors.forename: Westley H
authors.initials: WH
authors.lastname: Reeves
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D003863:Depression / Q000097:blood* / Q000523:psychology; D005221:Fatigue / Q000097:blood* / Q000523:psychology; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000097:blood* / Q000502:physiology; D008137:Longitudinal Studies; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007370:Interferon Type I