Leishmanicidal activity of racemic +/- 8-[(4-amino-1-methylbutyl)amino]-6-methoxy-4-methyl-5-[3,4-dichlorophenoxy]quinoline.
In this work we studied the in vitro toxicity of +/- 8-[(4-Amino-1-Methylbutyl)Amino]-6-Methoxy-4-Methyl-5-[3,4-dichlorophenoxy]quinoline (DN3-27-1) against stationary phase promastigotes Leishmania (L.) mexicana. Our results indicate that this drug induces an important reduction in parasite growth and killing compared to the reference drug N-methyl meglumine (Glucantime). DN3-27-1 was not toxic to Hela cells cultured in vitro. This is the first report describing the promising potential of DN3-27-1 in treatment of L. (L.) mexicana infections.
Isaac-Márquez
Angélica P
AP
Centro de Investigaciones en Enfermedades Tropicales, Universidad Autónoma de Campeche, Av. Patricio Trueba de Regil S/N, Campeche, Camp. 24090, México. anpisaac@hotmail.com
McChesney
James D
JD
Nanayakara
N P Dammika
NP
Satoskar
Abhay R
AR
Lezama-Dávila
Claudio M
CM
D000818:Animals; D000981:Antiprotozoal Agents / Q000737:chemistry* / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D007894:Leishmania mexicana / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D007928:Lethal Dose 50; D008536:Meglumine / Q000494:pharmacology; D000077485:Meglumine Antimoniate; D009043:Motor Activity / Q000187:drug effects; D009942:Organometallic Compounds / Q000494:pharmacology; D011804:Quinolines / Q000737:chemistry* / Q000633:toxicity
C549310:8-((4-amino-1-methylbutyl)amino)-6-methoxy-4-methyl-5-(3,4-dichlorophenoxy)quinoline; D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D011804:Quinolines; D008536:Meglumine; D000077485:Meglumine Antimoniate