title: Mechanisms and inhibition of HIV integration.
abstract: HIV integrase is required for viral replication and a rationale target for antiretroviral therapies. Integrase inhibitors are potentially complementary to current treatments. This review focuses on the mechanisms of HIV integration. The roles of viral and cellular co-factors during pre-integration complex (PIC) formation and integration are reviewed. The biochemical mechanisms of integration, integrase structures and approaches to inhibit integration are described.
authors.affiliation: Laboratory of Molecular Pharmacology, Bldg. 37, Rm. 5068, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892-4255.
authors.forename: Christophe
authors.initials: C
authors.lastname: Marchand
authors.forename: Allison A
authors.initials: AA
authors.lastname: Johnson
authors.forename: Elena
authors.initials: E
authors.lastname: Semenova
authors.forename: Yves
authors.initials: Y
authors.lastname: Pommier