Pregnancy and childbirth in carriers of the lamin A/C-gene mutation.
This retrospective case report describes 11 pregnancies in five women. All of the women were carriers of the lamin A/C gene mutation known to cause dilated cardiomyopathy, often together with atrioventricular conduction disturbances. The penetrance of these mutations is age-dependent but almost complete. We found no major adverse effects or worsening in the cardiac condition during or after the pregnancy in these patients. All babies were healthy except for one with a small ventricular septal defect, one diagnosed with tracheobronchomalasia, and one with a patent ductus arteriosus. None of these defects have been associated with lamin A/C mutations.
Palojoki
Eeva
E
Department of Cardiology, Helsinki University Central Hospital, Helsinki, Finland.
Kaartinen
Maija
M
Kaaja
Risto
R
Reissell
Eeva
E
Kärkkäinen
Satu
S
Kuusisto
Johanna
J
Heliö
Tiina
T
D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000235:genetics*; D005260:Female; D006801:Humans; D034904:Lamin Type A / Q000235:genetics*; D008875:Middle Aged; D009154:Mutation; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000235:genetics*; D012189:Retrospective Studies
D034904:Lamin Type A; C440308:lamin C