title: Biotransformation of alpha-cedrol and caryophyllene oxide by the fungus Neurospora crassa.
abstract: Incubation of alpha-cedrol and caryophyllene oxide with Neurospora crassa afforded 12beta-hydroxy cedrol, 10alpha-hydroxy cedrol, and 3beta-hydroxy cedrol, and 12beta-hydroxy caryophyllene oxide as major metabolites, respectively. The antibacterial and radical scavenging activities of the metabolites were evaluated in vitro using broth microdilution and bioauthographic techniques. However, no significant antibacterial and antioxidant activities were observed when compared with those of standard substances.
authors.affiliation: Department of Chemistry, Faculty of Arts and Sciences, Eskisehir Osmangazi University, Eskişehir, Turkey. ikiran@ogu.edu.tr
authors.forename: Ismail
authors.initials: I
authors.lastname: Kiran
authors.forename: Zeynep
authors.initials: Z
authors.lastname: Durceylan
authors.forename: Neşe
authors.initials: N
authors.lastname: Kirimer
authors.forename: K Hüsnü Can
authors.initials: KH
authors.lastname: Baser
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Noma
authors.forename: Fatih
authors.initials: F
authors.lastname: Demirci
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D001711:Biotransformation; D001713:Biphenyl Compounds / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009492:Neurospora crassa / Q000378:metabolism*; D010851:Picrates / Q000737:chemistry; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D013729:Terpenes; C078669:cedrol; C004931:1,1-diphenyl-2-picrylhydrazyl; C515179:caryophyllene oxide