Acute immune-mediated thrombocytopenia due to oxaliplatin administration: a case report.
Drug-induced acute thrombocytopenia is an extremely rare side effect that may occur immediately after oxaliplatin infusion. This potentially fatal reaction is immune mediated and can be anticipated by mild hemorrhagic signs during previous administrations. This is the first report of acute thrombocytopenia occurring during adjuvant treatment of colorectal cancer with oxaliplatin. Clinicians should be aware of this adverse event in order to prevent possible serious consequences and stop further oxaliplatin administration.
Pietrantonio
Filippo
F
Medical Oncology Unit 2, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
Di Bartolomeo
Maria
M
Buzzoni
Roberto
R
Bajetta
Emilio
E
D000208:Acute Disease; D000230:Adenocarcinoma / Q000188:drug therapy* / Q000601:surgery; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000601:surgery; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D000077150:Oxaliplatin; D017713:Platelet Transfusion; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology* / Q000628:therapy; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin