Low-dose valganciclovir as preemptive therapy for cytomegalovirus infection occurring in allogeneic stem cell transplant recipients.
Few data are available to date on the dose of oral valganciclovir as cytomegalovirus (CMV) preemptive therapy in stem cell transplantation patients. This study aimed to evaluate the efficacy and safety of low-dose valganciclovir (900 mg/day) as preemptive treatment in allotransplanted recipients. Valganciclovir was used in 34 patients who underwent allogeneic stem cell transplantation for hematological malignancies at the dose of 900 mg oral administration/day (12 patients, group 1) or 1,800 mg oral administration/day (22 patients, group 2). Thirty-two out of 34 patients (94%) obtained negativization of polymerase chain reaction for CMV at a median of 12.5 days from the beginning of valganciclovir administration (10/12 patients of group 1, 22/22 patients of group 2). We conclude that oral administration of valganciclovir can induce clearance of CMV viral load in about 2 weeks; moreover, lower-dose oral valganciclovir (900 mg/day) has a comparable efficacy to the proposed standard dose (1,800 mg/day).
Palladino
Mariangela
M
Department of Hematology, Università Cattolica del Sacro Cuore, Rome, Italy. mariangelapalladino@tiscali.it
Laurenti
Luca
L
Chiusolo
Patrizia
P
Piccioni
Paola
P
Innocenti
Idanna
I
Tarnani
Michela
M
Sorà
Federica
F
Sica
Simona
S
Leone
Giuseppe
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000008:administration & dosage*; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000097:blood / Q000517:prevention & control*; D005260:Female; D015774:Ganciclovir / Q000008:administration & dosage / Q000031:analogs & derivatives*; D019337:Hematologic Neoplasms / Q000097:blood / Q000628:therapy* / Q000821:virology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014184:Transplantation, Homologous; D000077562:Valganciclovir; D019562:Viral Load
D000998:Antiviral Agents; D000077562:Valganciclovir; D015774:Ganciclovir