Powerful actuation of magnetized microtools by focused magnetic field for particle sorting in a chip.
This paper describes a novel powerful noncontact actuation of a magnetically driven microtool (MMT), achieved by magnetization of the MMT and focusing of the magnetic field in a microfluidic chip for particle sorting. The following are the highlights of this study: (1) an MMT was successfully fabricated from a mixture of neodymium powder and polydimethylsiloxane; the MMT was magnetized such that it acted as an elastic micromagnet with a magnetic flux density that increased by about 100 times after magnetization, and (2) a pair of sharp magnetic needles was fabricated adjacent to a microchannel in a chip by electroplating, in order to focus the magnetic flux density generated by the electromagnetic coils below the biochip; these needles contribute to miniaturization of an actuation module that would enable the integration of multiple functions in the limited area of a chip. FEM analysis of the magnetic flux density around the MMT showed that the magnetic flux density in the setup with the magnetic needles was around 8 times better than that in the setup without the needles. By magnetization, the drive frequency of the MMT improved by about 10 times--from 18 Hz to 180 Hz. We successfully demonstrated the separation of copolymer beads of a particular size in a chip by image sensing.
Yamanishi
Yoko
Y
Japan Science & Technology Agency (JST), PRESTO, Department of Mechanical Science & Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya, 464-8603, Aichi-ken, Japan. yoko@mech.nagoya-u.ac.jp
Sakuma
Shinya
S
Onda
Kazuhisa
K
Arai
Fumihito
F
D020342:Finite Element Analysis; D007091:Image Processing, Computer-Assisted; D008280:Magnetics; D046208:Microchip Analytical Procedures / Q000379:methods*; D055616:Microtechnology