Clostridium difficile toxinotype XI (A-B-) exhibits unique arrangement of PaLoc and its upstream region.
Clostridium difficile toxinotype XI strains do not produce toxins A (TcdA) or B (TcdB) but do possess a nonfunctional remnant of the pathogenicity locus (PaLoc), bearing part of the sequence for tcdA. This is the first report of a type with absent upstream terminal PaLoc sequences and major genetic rearrangements of the PaLoc region.
Geric Stare
Barbara
B
Department of Biology, Biotechnical Faculty, University of Ljubljana, Vecna pot 111, Ljubljana, Slovenia. barbara.geric@guest.arnes.si
Rupnik
Maja
M
D001427:Bacterial Toxins / Q000235:genetics*; D016360:Clostridioides difficile / Q000235:genetics*; D004768:Enterotoxins / Q000235:genetics; D023061:Gene Order; D056426:Genetic Loci
D001427:Bacterial Toxins; D004768:Enterotoxins; C041348:tcdA protein, Clostridium difficile