title: NBRI16716A, a new antitumor compound against human prostate cancer cells, produced by Perisporiopsis melioloides Mer-f16716.
abstract: Prostate stroma can regulate the growth and metastasis of prostate cancer through the tumor-stromal cell interactions. Thus, small molecules that modulate the tumor-stromal cell interactions will have a chance to become new antitumor drugs. In the course of our screening of the modulators, we isolated three new natural compounds, NBRI16716A (1), NBRI16716B (2) and NBRI16716C (3), from the fermentation broth of Perisporiopsis melioloides Mer-f16716, although compound 2 was already reported as a chemical degradation product of isotriornicin. Compounds 1 and 2 inhibited the growth of human prostate cancer DU-145 cells in the coculture with human prostate stromal cells (PrSCs) more strongly than that of DU-145 cells alone. Furthermore, both compounds showed antitumor effect against xenograft models of DU-145 cells and PrSCs in vivo.
authors.affiliation: Numazu Bio-Medical Research Institute, Microbial Chemistry Research Center, Numazu-shi, Shizuoka, Japan. kawadam@bikaken.or.jp
authors.forename: Manabu
authors.initials: M
authors.lastname: Kawada
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Someno
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Inoue
authors.forename: Shun-ichi
authors.initials: S
authors.lastname: Ohba
authors.forename: Tohru
authors.initials: T
authors.lastname: Masuda
authors.forename: Taira
authors.initials: T
authors.lastname: Kato
authors.forename: Daishiro
authors.initials: D
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000627:therapeutic use / Q000633:toxicity; D001203:Ascomycota / Q000378:metabolism; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D011719:Pyrazines / Q000302:isolation & purification* / Q000627:therapeutic use / Q000633:toxicity
chemical_list: D000903:Antibiotics, Antineoplastic; C550745:NBRI16716A; D011719:Pyrazines