Lipid outward translocation by ABC proteins.
In humans, about 50 ABC proteins play physiologically important roles. Many ABC proteins are involved in lipid outward translocation and lipid homeostasis in the body, and defects in their functions cause various diseases. However, the precise mechanisms of substrate transport remain unclear. In bacteria, several ABC proteins are involved in the transport of lipoproteins and lipopolysaccharides from the inner to outer membrane, and their functioning is a prerequisite for survival. Their functions can be divided into "flip-flop" and "projection". In this review, human ABC proteins are compared to bacterial proteins to elucidate their mechanisms.
Nagao
Kohjiro
K
Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto, Japan.
Kimura
Yasuhisa
Y
Mastuo
Michinori
M
Ueda
Kazumitsu
K
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D002784:Cholesterol / Q000378:metabolism; D006801:Humans; D008070:Lipopolysaccharides / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D015262:Xenobiotics / Q000378:metabolism
D018528:ATP-Binding Cassette Transporters; D008070:Lipopolysaccharides; D008074:Lipoproteins; D010743:Phospholipids; D015262:Xenobiotics; D002784:Cholesterol