Hyperandrogenemia is independently associated with elevated alanine aminotransferase activity in young women with polycystic ovary syndrome.
BACKGROUND
Women with polycystic ovary syndrome (PCOS) have been implicated to have higher levels of alanine aminotransferase (ALT) because of the high prevalence of obesity.


OBJECTIVE
Our aim was to investigate the relationship between elevated ALT and aspartate aminotransferase (AST) activity and characteristic hyperandrogenism in women with PCOS.


METHODS
We conducted a cross-sectional case-control study in a reproductive endocrinology clinic and voluntary annual medical health check-up program of the health management center in a tertiary medical center.


METHODS
A total of 279 women with PCOS and 279 age-frequency-matched healthy women were studied.


METHODS
There were no interventions.


METHODS
All subjects underwent anthropometric measurement, clinical history recorded by questionnaires, and biochemical tests after an overnight fast.


RESULTS
The prevalence of elevated ALT and AST levels was significantly higher in women with PCOS than healthy control subjects. Multivariate regression analysis for women revealed that the presence of PCOS was significantly associated with elevated ALT but not AST after adjustment for age, obesity, and dyslipidemia. The level of androgenicity represented by free androgen index in women with PCOS was significantly related to elevated ALT and AST levels in multivariate regression models. Women with PCOS who had the highest quartile of free androgen index level had the highest risk of elevated ALT level after adjustment for age, obesity, insulin resistance, and dyslipidemia.


CONCLUSIONS
The risk of elevated ALT level is significantly higher in women with PCOS than those without, independent of obesity. The elevated ALT levels in women with PCOS were associated with the increased androgen levels, independent of obesity, insulin resistance, and dyslipidemia.
Chen
Mei-Jou
MJ
Department of Obstetrics and Gynecology, National Taiwan University Hospital, No. 7 Chung-Shan South Road, 100, Taipei, Taiwan.
Chiu
Han-Mo
HM
Chen
Chi-Ling
CL
Yang
Wei-Shiung
WS
Yang
Yu-Shih
YS
Ho
Hong-Nerng
HN
D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose; D001794:Blood Pressure; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D003430:Cross-Sectional Studies; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D006801:Humans; D017588:Hyperandrogenism / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology; D011085:Polycystic Ovary Syndrome / Q000097:blood*; D012044:Regression Analysis
D001786:Blood Glucose; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase