New 2-(2-phenylethyl)chromone derivatives from the seeds of Cucumis melo L var. reticulatus.
Chemical investigation of the methanolic extract of the seeds of Cucumis melo L. var. reticulatus (Cucurbitaceae) afforded three new chromone derivatives; 5,7-dihydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone 3, 5,7-dihydroxy-2-[2-(3,4-dihydroxyphenyl)ethyl]chromone 4, and 7-glucosyloxy-5-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone 6, together with three known compounds; beta-amyrin 1, beta-sitosterol 2, and beta-sitosterol-3-O-beta-glucopyranoside 5. Their structures were established by UV, IR, 1D and 2D NMR, in addition to mass spectroscopic data and comparison with literature data. The n-hexane and methanolic extracts were evaluated for their antimicrobial activity, as well as cytotoxic activity using the brine shrimp bioassay.
Ibrahim
Sabrin R M
SR
Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt. sabrins2002@yahoo.com
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D001156:Artemia; D002855:Chromatography, Thin Layer; D002867:Chromones / Q000737:chemistry* / Q000494:pharmacology; D028462:Cucumis / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry; D012639:Seeds / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
C549351:5,7-dihydroxy-2-(2-(4-hydroxyphenyl)ethyl)chromone; C549352:7-glucosyloxy-5-hydroxy-2-(2-(4-hydroxyphenyl)ethyl)chromone; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002867:Chromones; D010936:Plant Extracts