title: Minimal removal of raltegravir by hemodialysis in HIV-infected patients with end-stage renal disease.
abstract: Little is known about raltegravir removal by hemodialysis in patients with end-stage renal disease (ESRD). We therefore measured raltegravir concentrations in plasma in pre- and postdialyzer blood samples from 2 ESRD HIV-infected patients. The hemodialysis extraction ratio and raltegravir hemodialysis clearance were 5.5% and 9.1 ml/min in patient 1 and 9.5% and 19.1 ml/min in patient 2, respectively. Our results suggest minimal raltegravir removal by hemodialysis with no specific raltegravir dosage adjustments required in HIV-infected patients undergoing hemodialysis.
authors.affiliation: Lluita contra la Sida Foundation, HIV Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. jmolto@flsida.org
authors.forename: José
authors.initials: J
authors.lastname: Moltó
authors.forename: José
authors.initials: J
authors.lastname: Sanz-Moreno
authors.forename: Marta
authors.initials: M
authors.lastname: Valle
authors.forename: Samandhy
authors.initials: S
authors.lastname: Cedeño
authors.forename: Jordi
authors.initials: J
authors.lastname: Bonal
authors.forename: Hanane
authors.initials: H
authors.lastname: Bouarich
authors.forename: Bonaventura
authors.initials: B
authors.lastname: Clotet
mesh_terms: D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy*; D019428:HIV Integrase Inhibitors / Q000097:blood* / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011760:Pyrrolidinones / Q000097:blood* / Q000627:therapeutic use*; D000068898:Raltegravir Potassium; D006435:Renal Dialysis / Q000379:methods*
chemical_list: D019428:HIV Integrase Inhibitors; D011760:Pyrrolidinones; D000068898:Raltegravir Potassium