title: Layer-by-layer assembly of poly(lactic acid) nanoparticles: a facile way to fabricate films for model drug delivery.
abstract: Layer-by-layer (LBL) films of poly(lactic acid) nanoparticles (PLA NPs) and poly(ethyleneimine) (PEI) were fabricated as a novel drug-delivery system. The PLA NPs, which encapsulated pyrene as a model drug, were prepared by nanoprecipitation methods. The assembly process of PLA NPs/PEI LBL films was monitored by UV-vis spectroscopy, and the load of pyrene in the multilayer films was verified by fluorescence spectroscopy. The morphology of the PLA NPs/PEI LBL films was observed by SEM. The release profile of pyrene from the LBL films in PBS solutions was further studied, and the result indicated that the PLA NPs/PEI films were capable of sustainably releasing pyrene as expected. The fabrication of PLA NPs/PEI LBL films provides a new facile method for drug delivery and paves the way for loading multiple types of drugs into a single LBL film.
authors.affiliation: College of Sciences, Northeastern University, Shenyang 110004, China.
authors.forename: Yong-Hua
authors.initials: YH
authors.lastname: Jiao
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Shu
authors.initials: S
authors.lastname: Wang
authors.forename: Kai
authors.initials: K
authors.lastname: Zhang
authors.forename: Ying-Gang
authors.initials: YG
authors.lastname: Jia
authors.forename: Yu
authors.initials: Y
authors.lastname: Fu
mesh_terms: D004337:Drug Carriers; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles; D011091:Polyesters; D011108:Polymers / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D004337:Drug Carriers; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)