[Effect of huoxueyiqimingmu capsule on retinal degenerative diseases].
OBJECTIVE
To investigate therapeutic effects of Huoxueyiqimingmu capsule on retinal degenerative diseases.


METHODS
Sixty SD rats were randomly divided into three groups: negative control group, light damage model group, Huoxueyiqimingmu capsule group. The light damage model was used as retinal degenerative diseases animal model. Normal saline and Huoxueyiqimingmu capsule were respectively administrated after light damage. After 14 days post-treatment, the change of electroretinogram was observed, content of malondialdehyde (MDA) and activity of superoxide dismutase (SOD) in rats retina were determined, and histopathologic changes were observed with transmission electron microscopy and light microscopy.


RESULTS
After 14 days post-treatment, Huoxueyiqimingmu capsule had protective effects on fall of ERG a wave and b wave amplitude induced by light damage. The activity of SOD in Huoxueyiqimingmu capsule group was higher than that in light damage model group (P < 0.01), while the content of MDA in Huoxueyiqimingmu capsule group was lower than that in light damage model group (P < 0.01). The histopathologic injury of rat retina in Huoxueyiqimingmu capsule group was lighter than that in light damage model group by means of transmission electron microscopy and light microscopy.


CONCLUSIONS
Huoxueyiqimingmu capsule is effective to treat retinal degenerative diseases.
Wang
Yan-dong
YD
Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China. wangydsyj@yahoo.com.cn
Tang
Xi-lan
XL
Zhu
Xiao-bo
XB
Tang
Shi-bo
SB
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002214:Capsules; D004195:Disease Models, Animal; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D004596:Electroretinography; D005260:Female; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D046529:Microscopy, Electron, Transmission; D010775:Photic Stimulation; D010946:Plants, Medicinal / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012160:Retina / Q000187:drug effects* / Q000293:injuries / Q000378:metabolism; D012164:Retinal Diseases / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D008315:Malondialdehyde; D013482:Superoxide Dismutase