title: Radiation-induced glioblastoma occurring 35 years after radiation therapy for medulloblastoma: case report.
abstract: A 41-year-old man was admitted in June 2007 with a 1-month history of headache and cerebellar ataxia. At the age of 5 years, in May 1971, he had presented with headache, vomiting, and gait disturbance. Cerebral angiographical study demonstrated vascular shift caused by a mass lesion in the cerebellar vermis. He had immediately undergone partial removal. Histological diagnosis was medulloblastoma (MB). Postoperatively he received a total of 40 Gy radiation to the whole brain and 30.5 Gy to the spine without chemotherapy. He was again seen 35 years later with a radiation-induced glioblastoma (GB) that arose in the region of the original MB. The tumor was surgically removed, and he received radiotherapy and chemotherapy with ACNU, procarbazine, and vincristine. Postoperative irradiation reduced the size of the second tumor.
authors.affiliation: Department of Neurosurgery, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan. hamakiyo1220@hotmail.com
authors.forename: Kiyotoshi
authors.initials: K
authors.lastname: Hamasaki
authors.forename: Hideo
authors.initials: H
authors.lastname: Nakamura
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Ueda
authors.forename: Keishi
authors.initials: K
authors.lastname: Makino
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Kuratsu
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002528:Cerebellar Neoplasms / Q000628:therapy*; D005909:Glioblastoma / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000532:radiotherapy*; D016609:Neoplasms, Second Primary; D019635:Neurosurgical Procedures; D015376:Nimustine / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D011878:Radiotherapy / Q000009:adverse effects*; D013997:Time Factors; D016896:Treatment Outcome; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D015376:Nimustine; D011344:Procarbazine; D014750:Vincristine