title: [Establishment of the animal model with unilateral alveolar cleft and its effect on the nose growth].
abstract: OBJECTIVE
  To establish the animal model with unilateral alveolar cleft and its effect on the nose growth.
  
  
  METHODS
  10 dogs were used. One side was selected to receive operation to create alveolar cleft, with the unoperated side as control side. The alveolar cleft was 10 mm in width. The dogs were harvested 10 weeks later. With the 3-D reconstruction of skull, cephalometric measurement was performed and analyzed with Amira software, the bilateral alar cartilage was dissected for comparison of cartilage growth.
  
  
  RESULTS
  The alveolar was not closed. The growth of alar cartilage on cleft side was poor, with asymmetric nostril. The lateral crus of alar on the cleft side was down-displaced. The nasal tip was deviated to the healthy side, with the columella to the cleft side. Histologic study showed better cartilage growth in healthy side than in cleft side.
  
  
  CONCLUSIONS
  The unnormal mechanical structure in unilateral alveolar cleft can affect the alar cartilage growth and nose shape. Early repair may improve the bony structure for alar development, as well as the soft tissue growth.
authors.affiliation: Department of Plastic Surgery, First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
authors.forename: Li-li
authors.initials: LL
authors.lastname: Wu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
mesh_terms: D000539:Alveolar Process / Q000293:injuries*; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D009666:Nose / Q000254:growth & development*