title: Lactate response to short term exercise with elevated starting levels.
abstract: A model that describes the blood lactate concentration (BLC) dynamics [BLC(t)] of a Wingate Anaerobic Test (WAnT) as a function of (a) BLC at the start of exercise (BLC(0)), (b) extra-vascular increase in lactate (A), (c) two corresponding velocity constants of appearance (k (1)) and disappearance (k (2)) of lactate into and out of the blood requires that BLC(0) is equal to resting BLC (BLC(rest)). We developed a model that considers an elevated BLC(0). 19 males performed WAnTs with warm-ups increasing (p < 0.001) BLC(0). The goodness of each individual fit improved (p < 0.05) if the difference between BLC(rest) and BLC(0) (DeltaBLC) was higher than 1.0 mmol l(-1). All differences between old and new model (p < 0.05) in A, k (1) and k (2) were interrelated with and increased with DeltaBLC (p < 0.05). The new model well describes BLC(t) and prevents substantial errors concerning lactate generation and dynamics if BLC(0) is elevated by more than 1.0 mmol l(-1).
authors.affiliation: Department of Biological Sciences, Centre for Sports and Exercise Science, University of Essex, Wivenhoe Park, Colchester, CO4 3SQ, UK. rbeneke@essex.ac.uk
authors.forename: Ralph
authors.initials: R
authors.lastname: Beneke
authors.forename: Anna
authors.initials: A
authors.lastname: Wittekind
authors.forename: Monika
authors.initials: M
authors.lastname: Mühling
authors.forename: Imogen
authors.initials: I
authors.lastname: Bleif
authors.forename: Renate M
authors.initials: RM
authors.lastname: Leithäuser
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D015444:Exercise; D005080:Exercise Test; D006801:Humans; D007700:Kinetics; D019344:Lactic Acid / Q000097:blood*; D008297:Male; D008954:Models, Biological; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000378:metabolism*; D020127:Recovery of Function; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015415:Biomarkers; D019344:Lactic Acid