title: A novel oxazolidinone antibiotic: RWJ-416457.
abstract: The crystal structure of the antibiotic drug candidate RWJ-416457 (systematic name: N-{(5S)-3-[4-(5,6-dihydro-2H,4H-2-methylpyrrolo[3,4-c]pyrazol-5-yl)-3-fluorophenyl]-2-oxo-1,3-oxazolidin-5-yl}acetamide), C(18)H(20)FN(5)O(3), which belongs to the first new class of antibiotics discovered in the past 30 years, has been determined at 150 K. Each molecule of this drug donates one hydrogen bond to a neighboring molecule and accepts one hydrogen bond to give (O=C-R-N-H...O=C-R-N-H...)(n) linkages along the b-axis direction. The compound contains a pyrrolopyrazole ring, which, owing to its uncommon structure, has been shown to have particular effectiveness against multi-drug-resistant bacteria.
authors.affiliation: Amgen Inc., 360 Binney Street, Cambridge, MA 02142, USA. eugene.cheung@amgen.com
authors.forename: Eugene Y
authors.initials: EY
authors.lastname: Cheung
authors.forename: Matthew L
authors.initials: ML
authors.lastname: Peterson
authors.forename: Renato
authors.initials: R
authors.lastname: Chiarella
authors.forename: Bruce M
authors.initials: BM
authors.lastname: Foxman
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects*; D006860:Hydrogen Bonding; D008958:Models, Molecular; D015394:Molecular Structure; D023303:Oxazolidinones / Q000737:chemistry* / Q000494:pharmacology*; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; C518323:RWJ-416457