title: [The use of platelet-rich fibrin membrane in gingival recession treatment].
abstract: BACKGROUND
  Fibrin, fibronectin, platelet derived growth factor, and transforming growth factors from platelet concetrate are crucial for tissue reparation and regeneration.
  
  
  OBJECTIVE
  This study was designed to evaluate clinical effectiveness of activated platelet-rich fibrin (PRF) membrane in treatment of gingival recession.
  
  
  METHODS
  19 gingival recessions Miller class I or II were treated with a coronally advanced flap and the PRF membrane (PRF group). Following the elevation of the flap, bone and root surfaces were covered with the PRF membrane. After suturing, the PRF membrane was covered with a coronally advanced flap. In the same patients, 19 other gingival recessions were treated with CTG in combination with the coronally advanced flap (the CTG group). Clinical recordings were made of vertical recession depth (VRD), probing depth (PD), clinical attachment level (CAL) and keratinized tissue width (KTW) before and 12 months after mucogingival surgical treatment. Clinical evaluation of healing events was estimated with recordings of the healing index (HI). Recordings of HI were performed in the 1st, 2nd and 3rd week post-surgically.
  
  
  RESULTS
  Mean root coverage was significant in both groups (the PRF group 79.94% and the CTG group 88.56% %; p < 0.01). The difference between the two tested groups was not statistically significant. Results of the keratinized tissue width showed significant increase (p < 0.05) 12 months after the surgery in both, the PRF and CTG groups. Results of KTW showed statistical significance of recorded differences obtained in the two evaluated groups (p < 0.05). There was no statistical significance in reduction of PD and CAL recorded in the PRF and CTG groups. The values of HI recorded in the 1st and 2nd week postoperatively were significantly enhanced in the PRF group (p < 0.05).
  
  
  CONCLUSIONS
  Results of this study confirm both procedures as effective with equivalence of clinical results in solving gingival recession problems. The utilization of the PRF resulted in a decreased postoperative discomfort and advanced tissue healing.
authors.forename: Zoran
authors.initials: Z
authors.lastname: Aleksić
authors.forename: Sasa
authors.initials: S
authors.lastname: Janković
authors.forename: Bozdar
authors.initials: B
authors.lastname: Dimitrijević
authors.forename: Tihana
authors.initials: T
authors.lastname: Divnić-Resnik
authors.forename: Iva
authors.initials: I
authors.lastname: Milinković
authors.forename: Vojislav
authors.initials: V
authors.lastname: Leković
mesh_terms: D000328:Adult; D001792:Blood Platelets; D005260:Female; D005337:Fibrin; D005889:Gingival Recession / Q000601:surgery*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D013524:Surgical Flaps; D014945:Wound Healing
chemical_list: D008567:Membranes, Artificial; D005337:Fibrin