title: Evaluation of the antihypertensive effect of L-arginine supplementation in patients with mild hypertension assessed with ambulatory blood pressure monitoring.
abstract: BACKGROUND
  Arterial hypertension is one of the most important cardiovascular risk factors, featuring the unsatisfactory efficacy of current therapies. The cardiovascular disease paradigm which assumes a crucial role of the endothelial phenotype in shaping the state of the circulatory system has become increasingly dominant and endothelial dysfunction should be treated as avidly as the diseases of other organs. The most valued current anti-hypertensive therapies exert a positive influence on the endothelium due to their pleiotropic effects, but the search for new effective strategies aimed at improving endothelial function is underway. L-arginine trials are part of this quest. The few L-arginine studies in hypertension have brought inconclusive results. The aim of this study was to evaluate the anti-hypertensive efficacy and safety profile of L- arginine during four weeks of oral supplementation to healthy subjects and patients diagnosed with primary mild hypertension.
  
  
  METHODS
  The study was completed by 54 participants. Ambulatory blood pressure monitoring (ABPM) was used to allot patients to either a healthy control group (19 subjects) or the hypertensive treatment group (35 patients). Later the patients were randomized to either L-arginine (2 or 4 g three times daily or placebo. All participants underwent physical examination and had all basic lab tests and ABPM performed.
  
  
  RESULTS
  Blood pressure (both systolic and diastolic) by ABPM showed statistically significant lowering after 4 weeks of L-arginine supplementation only in the subgroup of patients treated with 12 g of L-arginine daily, with a stronger hypotensive effect observed during the day.
  
  
  CONCLUSIONS
  The present findings demonstrate a strong association between L-arginine supplementation and blood pressure reduction.
authors.affiliation: Department of Clinical Pharmacology, Karol Marcinkowski University of Medical Science, Poznan, Poland.
authors.forename: Jarosław
authors.initials: J
authors.lastname: Ast
authors.forename: Anna
authors.initials: A
authors.lastname: Jablecka
authors.forename: Pawel
authors.initials: P
authors.lastname: Bogdanski
authors.forename: Iwona
authors.initials: I
authors.lastname: Smolarek
authors.forename: Hanna
authors.initials: H
authors.lastname: Krauss
authors.forename: Ewa
authors.initials: E
authors.lastname: Chmara
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001120:Arginine / Q000627:therapeutic use*; D018660:Blood Pressure Monitoring, Ambulatory; D016022:Case-Control Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D011446:Prospective Studies
chemical_list: D000959:Antihypertensive Agents; D001120:Arginine