title: Comparison of intensity-modulated radiotherapy using helical tomotherapy and segmental multileaf collimator-based techniques for nasopharyngeal carcinoma: dosimetric analysis incorporating quality assurance guidelines from RTOG 0225.
abstract: Intensity-modulated radiotherapy (IMRT) treatment plans generated by segmental multileaf collimator (SMLC) and helical tomotherapy (HT) techniques for patients with nasopharyngeal carcinoma were compared using standardized criteria proposed by Radiation Therapy Oncology Group (RTOG) protocol 0225. The goal was to deliver a prescribed dose of 70 Gy to at least 95% of the planning target volume (PTV) encompassing gross tumor, and 59.4 Gy and 50.4 Gy, respectively, to areas at high and low risk for microscopic disease, over 33 treatments while respecting constraints to organs at risk (OAR). HT-IMRT significantly reduced dose to the contralateral parotid gland and improved dose homogeneity to the PTVs. Mean doses to the inner and middle ears were also reduced by 18% and 24%, respectively, on the ipsilateral side, and 24%, and 35%, respectively, on the contralateral side using HT-IMRT compared to SMLC-IMRT. Additionally, HT-IMRT reduced mean doses to brainstem (p = 0.02), larynx (p = 0.03), and oral cavity (p = 0.03). These findings suggest that HT-IMRT may be of improve the therapeutic ratio in the radiotherapeutic treatment of nasopharyngeal carcinoma.
authors.affiliation: Departments of Radiation Oncology, University of California Davis Cancer Center, 4501 X Street, Suite G140, Sacramento, CA, USA. allen.chen@ucdmc.ucdavis.edu
authors.forename: Allen  M
authors.initials: A
authors.lastname: Chen
authors.forename: Nancy  Y
authors.initials: N
authors.lastname: Lee
authors.forename: Claus  C
authors.initials: C
authors.lastname: Yang
authors.forename: Tianxiao
authors.initials: T
authors.lastname: Liu
authors.forename: Samir
authors.initials: S
authors.lastname: Narayan
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Vijayakumar
authors.forename: James  A
authors.initials: J
authors.lastname: Purdy
mesh_terms: D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D011785:Quality Assurance, Health Care / Q000592:standards*; D011879:Radiotherapy Dosage / Q000592:standards*; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods* / Q000592:standards; D050397:Radiotherapy, Intensity-Modulated / Q000295:instrumentation / Q000379:methods* / Q000592:standards*; D036542:Tomography, Spiral Computed / Q000379:methods / Q000592:standards