Repeated angioedema following administration of venlafaxine and mirtazapine.
We report a rare case of a 48-year-old female who presented with bilateral lower-leg swelling due to a medication-induced angioedema resulting from the use of two common classes of antidepressants, venlafaxine and mirtazapine. Although the mechanisms by which the antidepressants achieve these effects are not understood, the recent recognition of a novel antidepressant-dependent form of angioedema may offer important insights into the mechanisms by which the antidepressants exert their effects.
Lin
Ching-En
CE
Department of Psychiatry, Tri-Service General Hospital, Taipei 114, Taiwan. chingen_lin@yahoo.com.tw
Chen
Chih-Lun
CL
D000799:Angioedema / Q000139:chemically induced*; D018687:Antidepressive Agents, Second-Generation / Q000008:administration & dosage / Q000009:adverse effects*; D000929:Antidepressive Agents, Tricyclic / Q000008:administration & dosage / Q000009:adverse effects*; D003511:Cyclohexanols / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007866:Leg / Q000503:physiopathology; D008803:Mianserin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D008875:Middle Aged; D000078785:Mirtazapine; D000069470:Venlafaxine Hydrochloride
D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D003511:Cyclohexanols; D008803:Mianserin; D000069470:Venlafaxine Hydrochloride; D000078785:Mirtazapine