title: Detection of novel Human papilloma virus type 82 in laryngeal cancer: case report.
abstract: Human papilloma virus infection is thought to play a role in laryngeal carcinogenesis; the variable association reported in literature may be due to wide range of HPV genotypes. We report the case of a 51-year-old man affected by laryngeal squamous cell carcinoma; analysis of DNA extracted by cancer cells by an innovative molecular virology assay (INNO-LiPA HPV Genotyping Extra) showed the presence of two high-risk HPV genotypes, HPV-73 and -82. Immunohistochemical examination confirmed positivity for both capsid protein and viral oncogenic protein E7. Such association has never been reported in literature so far, and a brief discussion on the importance of assessing HPV status in laryngeal cancer is provided.
authors.affiliation: Department of Surgical Sciences, Institute of Pathology and Cytopathology, University of Foggia, Viale Pinto, Foggia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pannone
authors.forename: F
authors.initials: F
authors.lastname: Sanguedolce
authors.forename: A
authors.initials: A
authors.lastname: Santoro
authors.forename: P
authors.initials: P
authors.lastname: Fierro
authors.forename: M
authors.initials: M
authors.lastname: Panetti
authors.forename: D
authors.initials: D
authors.lastname: Fierro
authors.forename: F
authors.initials: F
authors.lastname: Maiello
authors.forename: S
authors.initials: S
authors.lastname: De Maria
authors.forename: A
authors.initials: A
authors.lastname: Giannattasio
authors.forename: R
authors.initials: R
authors.lastname: Serpico
authors.forename: L
authors.initials: L
authors.lastname: Lo Muzio
authors.forename: S
authors.initials: S
authors.lastname: Metafora
authors.forename: P
authors.initials: P
authors.lastname: Bufo
mesh_terms: D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000821:virology*; D015344:DNA Probes, HPV; D005838:Genotype; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000821:virology*; D007825:Laryngectomy; D007830:Larynx / Q000473:pathology / Q000821:virology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009367:Neoplasm Staging; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000821:virology*; D014057:Tomography, X-Ray Computed
chemical_list: D015344:DNA Probes, HPV