title: H1/H1 genotype influences symptom severity in corticobasal syndrome.
abstract: We evaluated 38 consecutive patients with corticobasal syndrome to determine if inheritance of the H1/H1 genotype influences age at onset and disease severity and if Apolipoprotein E e4 increases the risk of cognitive disturbances. Inheritance of the H1/H1 genotype was associated with severity of motor function, but did not affect age at onset or cognition. There was a trend toward shorter survival in the H1/H1 group, but this study was underpowered to test influence on survival, even though it served to estimate the sample size for future studies. ApoE inheritance did not influence cognition.
authors.affiliation: Division of Movement Disorders, Department of Neurology, University of Louisville, Louisville, Kentucky 40202, USA. i.litvan@louisville.edu
authors.forename: Irene
authors.initials: I
authors.lastname: Litvan
authors.forename: Amanda
authors.initials: A
authors.lastname: Chism
authors.forename: Juan
authors.initials: J
authors.lastname: Litvan
authors.forename: Alex
authors.initials: A
authors.lastname: Cambon
authors.forename: Michael
authors.initials: M
authors.lastname: Hutton
mesh_terms: D017668:Age of Onset; D053327:Apolipoprotein E4 / Q000235:genetics; D016022:Case-Control Studies; D004421:Dystonia / Q000150:complications / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D011596:Psychomotor Disorders / Q000150:complications / Q000235:genetics*; D012720:Severity of Illness Index; D013577:Syndrome; D016875:tau Proteins / Q000235:genetics*
chemical_list: D053327:Apolipoprotein E4; D016875:tau Proteins