title: 2-Octyl-cyanoacrylate for wound closure in cervical and lumbar spinal surgery.
abstract: It is claimed that wound closure with 2-octyl-cyanoacrylate has the advantages that band-aids are not needed in the postoperative period, that the wound can get in contact with water and that removal of stitches is not required. This would substantially enhance patient comfort, especially in times of reduced in-hospital stays. Postoperative wound infection is a well-known complication in spinal surgery. The reported infection rates range between 0% and 12.7%. The question arises if the advantages of wound closure with 2-octyl-cyanoacrylate in spinal surgery are not surpassed by an increase in infection rate. This study has been conducted to identify the infection rate of spinal surgery if wound closure was done with 2-octyl-cyanoacrylate. A total of 235 patients with one- or two-level surgery at the cervical or lumbar spine were included in this prospective study. Their pre- and postoperative course was evaluated. Analysis included age, sex, body mass index, duration and level of operation, blood examinations, 6-week follow-up and analysis of preoperative risk factors. The data were compared to infection rates of similar surgeries found in a literature research and to a historical group of 503 patients who underwent wound closure with standard skin sutures after spine surgery. With the use of 2-octyl-cyanoacrylate, only one patient suffered from postoperative wound infection which accounts for a total infection rate of 0.43%. In the literature addressing infection rate after spine surgery, an average rate of 3.2% is reported. Infection rate was 2.2% in the historical control group. No risk factor could be identified which limited the usage of 2-octyl-cyanoacrylate. 2-Octyl-cyanoacrylate provides sufficient wound closure in spinal surgery and is associated with a low risk of postoperative wound infection.
authors.affiliation: Department of Neurosurgery, University Clinics of Giessen and Marburg GmbH, Campus Giessen, Giessen, Germany. dorothee.wachter@gmx.de
authors.forename: Dorothee
authors.initials: D
authors.lastname: Wachter
authors.forename: Anja
authors.initials: A
authors.lastname: Brückel
authors.forename: Marco
authors.initials: M
authors.lastname: Stein
authors.forename: Matthias F
authors.initials: MF
authors.lastname: Oertel
authors.forename: Petros
authors.initials: P
authors.lastname: Christophis
authors.forename: Dieter-Karsten
authors.initials: DK
authors.lastname: Böker
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002574:Cervical Vertebrae / Q000601:surgery*; D003430:Cross-Sectional Studies; D003487:Cyanoacrylates / Q000009:adverse effects; D005260:Female; D006801:Humans; D008159:Lumbar Vertebrae / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013123:Spinal Fusion; D013131:Spine / Q000601:surgery*; D013530:Surgical Wound Infection / Q000517:prevention & control; D014014:Tissue Adhesives / Q000009:adverse effects; D058106:Wound Closure Techniques
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives; C100832:octyl 2-cyanoacrylate