Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex.
Herein, we show that a naturally occurring RNA G-quadruplex element within the 5' UTR of the human NRAS proto-oncogene is a target for a small molecule that inhibits translation in vitro. The present study provides a first demonstration that natural 5' UTR mRNA G-quadruplexes have potential as molecular targets for small molecules that modulate translation.
Bugaut
Anthony
A
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW.
Rodriguez
Raphaël
R
Kumari
Sunita
S
Hsu
Shang-Te Danny
ST
Balasubramanian
Shankar
S
D020121:5' Untranslated Regions; D001483:Base Sequence; D054856:G-Quadruplexes; D008024:Ligands; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D000090063:Proto-Oncogene Mas; D012313:RNA / Q000737:chemistry*; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism
D020121:5' Untranslated Regions; D008024:Ligands; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger; D012313:RNA