[Acute bilateral angle-closure glaucoma induced by topiramate: contribution of Visante OCT].
BACKGROUND
Topiramate, a sulfamate-substituted monosaccharide classically used as an antiepileptic medication, has been widely used since its recent indication for migraine prophylaxis. We report the case of a 68-year-old woman who developed bilateral acute glaucoma following topiramate migraine prophylaxis.


METHODS
A 68-year-old woman presented in the emergency department for ocular pain, redness, and bilateral reduced visual acuity associated with nausea and vomiting. Initial examination found a bilateral corneal edema with shallow anterior chambers and closed iridocorneal angles. Intraocular pressure was 40mmHg in the right eye and 45mmHg in the left eye. Ultrasound biomicroscopy diagnosed ciliochoroidal detachment and swollen ciliary processes with closed angles, which was also objectified using the Visante OCT. Topiramate treatment was interrupted and a local and general hypotonic treatment was started. After 4 days, examination showed deeper anterior chambers and normal intraocular pressures. Visante OCT and ocular echography follow-up examinations were normal, and Indoramin was prescribed for migraine prophylaxis with no relapse after 10 months.


CONCLUSIONS
Bilateral acute angle-closure glaucoma is a possible complication of topiramate. Physicians and patients starting this therapy should be aware of this underestimated risk.
Tahiri Joutei Hassani
R
R
Service d'ophtalmologie III, Centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France.
Dupont Monod
S
S
Oukacha
G
G
Mantout
F
F
Benrabah
R
R
Heron
E
E
Baudouin
C
C
D000208:Acute Disease; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects*; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D015812:Glaucoma, Angle-Closure / Q000139:chemically induced* / Q000175:diagnosis*; D006801:Humans; D041623:Tomography, Optical Coherence; D000077236:Topiramate
D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose