Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways.
Phosphatidylinositol 5-phosphate (PtdIns5P) is emerging as a potential lipid messenger involved in several cell types, from plants to mammals. Expression of IpgD, a PtdIns(4,5)P(2) 4-phosphatase induces Src kinase and Akt, but not ERK activation and enhances interleukin II promoter activity in T-cells. Expression of a new PtdIns5P interacting domain blocks IpgD-induced T-cell activation and selective signaling molecules downstream of TCR triggering. Altogether, these data suggest that PtdIns5P may play a sensor function in setting the threshold of T-cell activation and contributing to maintain T-cell homeostasis.
Guittard
Geoffrey
G
Institut National de la Santé et de la Recherche Médicale, Unité 891, Centre de Recherche en Cancérologie de Marseille, Marseille, France.
Mortier
Eva
E
Tronchère
Hélène
H
Firaguay
Guylène
G
Gérard
Audrey
A
Zimmermann
Pascale
P
Payrastre
Bernard
B
Nunès
Jacques A
JA
D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism; D008213:Lymphocyte Activation; D018129:Phosphatidylinositol Phosphates / Q000502:physiology*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D010944:Plants / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000378:metabolism*; D019061:src-Family Kinases / Q000378:metabolism
D007376:Interleukin-2; D018129:Phosphatidylinositol Phosphates; D011948:Receptors, Antigen, T-Cell; C113567:phosphatidylinositol 5-phosphate; D019061:src-Family Kinases; D051057:Proto-Oncogene Proteins c-akt; D010744:Phosphoric Monoester Hydrolases