title: A combinatorial multicomponent plug mixer for systems chemistry.
abstract: We report the construction and testing of a combinatorial multicomponent plug mixer (CMPM) chip that generates a large number of mix ratios. The CMPM chip has been designed to study ribonucleotide reductase (RNR) protein-protein/protein-ligand interaction networks. The 4-component chip is capable of 5400 different combinations in a 30 plug cycle. CMPM chips were tested producing fluorescent dye and dihydrofolate reductase NADPH/MX mixtures with plug lengths of 2 mm.
authors.forename: F
authors.initials: F
authors.lastname: Azizi
authors.forename: Q
authors.initials: Q
authors.lastname: Wan
authors.forename: T
authors.initials: T
authors.lastname: Radivoyevitch
authors.forename: C
authors.initials: C
authors.lastname: Dealwis
authors.forename: C H
authors.initials: CH
authors.lastname: Mastrangelo