title: Genome wide scan for quantitative trait loci affecting tick resistance in cattle (Bos taurus x Bos indicus).
abstract: BACKGROUND
  In tropical countries, losses caused by bovine tick Rhipicephalus (Boophilus) microplus infestation have a tremendous economic impact on cattle production systems. Genetic variation between Bos taurus and Bos indicus to tick resistance and molecular biology tools might allow for the identification of molecular markers linked to resistance traits that could be used as an auxiliary tool in selection programs. The objective of this work was to identify QTL associated with tick resistance/susceptibility in a bovine F2 population derived from the Gyr (Bos indicus) x Holstein (Bos taurus) cross.
  
  
  RESULTS
  Through a whole genome scan with microsatellite markers, we were able to map six genomic regions associated with bovine tick resistance. For most QTL, we have found that depending on the tick evaluation season (dry and rainy) different sets of genes could be involved in the resistance mechanism. We identified dry season specific QTL on BTA 2 and 10, rainy season specific QTL on BTA 5, 11 and 27. We also found a highly significant genome wide QTL for both dry and rainy seasons in the central region of BTA 23.
  
  
  CONCLUSIONS
  The experimental F2 population derived from Gyr x Holstein cross successfully allowed the identification of six highly significant QTL associated with tick resistance in cattle. QTL located on BTA 23 might be related with the bovine histocompatibility complex. Further investigation of these QTL will help to isolate candidate genes involved with tick resistance in cattle.
authors.affiliation: Embrapa Gado de Leite, Juiz de Fora, MG, Brazil. machado@cnpgl.embrapa.br
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Machado
authors.forename: Ana Luisa S
authors.initials: AL
authors.lastname: Azevedo
authors.forename: Roberto L
authors.initials: RL
authors.lastname: Teodoro
authors.forename: Maria A
authors.initials: MA
authors.lastname: Pires
authors.forename: Maria Gabriela C D
authors.initials: MG
authors.lastname: Peixoto
authors.forename: Célio
authors.initials: C
authors.lastname: de Freitas
authors.forename: Márcia Cristina A
authors.initials: MC
authors.lastname: Prata
authors.forename: John
authors.initials: J
authors.lastname: Furlong
authors.forename: Marcos Vinicius G B
authors.initials: MV
authors.lastname: da Silva
authors.forename: Simone E F
authors.initials: SE
authors.lastname: Guimarães
authors.forename: Luciana C A
authors.initials: LC
authors.lastname: Regitano
authors.forename: Luiz L
authors.initials: LL
authors.lastname: Coutinho
authors.forename: Gustavo
authors.initials: G
authors.lastname: Gasparin
authors.forename: Rui S
authors.initials: RS
authors.lastname: Verneque
mesh_terms: D000818:Animals; D002417:Cattle / Q000235:genetics* / Q000276:immunology*; D002418:Cattle Diseases / Q000235:genetics* / Q000276:immunology*; D005260:Female; D055106:Genome-Wide Association Study; D040641:Quantitative Trait Loci; D048494:Rhipicephalus / Q000502:physiology; D013984:Tick Infestations / Q000235:genetics / Q000276:immunology / Q000662:veterinary*