Diversity oriented synthesis of pyrrolidines via natural carbohydrate solid acid catalyst.
Natural carbohydrate scaffold catalyzed diastereoselective synthesis of functionalized pyrrolidines have been developed via 1,3-dipolar cycloaddition of azomethine ylides derived from alpha-imino esters with dienes or dipolarophiles. Naturally most abundant carbohydrates, like cellulose and starch, were converted into their sulfuric acid derivative, which are exhibiting efficient catalytic properties, along with excellent cost effectivity and recyclability. The advantages of this methodology are diversity oriented metal free synthesis of functionalized pyrrolidines, mild reaction condition, high diasteroselectivity and yield.
Kumar
Atul
A
Medicinal and Process Chemistry Division, Central Drug Research Institute, Lucknow, India. dratulsax@gmail.com
Gupta
Garima
G
Srivastava
Suman
S
D002241:Carbohydrates / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D008968:Molecular Conformation; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D002241:Carbohydrates; D011759:Pyrrolidines