title: 5-Hydroxy-5,6-dihydro-apo-4,4'-lycopene and methyl 5-hydroxy-5,6-dihydro-apo-4,4'-lycopenoate, novel C(30)-carotenoids produced by a mutant of marine bacterium Halobacillus halophilus [corrected].
abstract: We performed the chemical mutagenesis of Halobacillus halophilus (the producer of a C(30) carotenoid, methyl glucosyl-3,4-dehydro-apo-8'-lycopenoate) to isolate novel carotenoids that are biosynthetic intermediates of methyl glucosyl-3,4-dehydro-apo-8'-lycopenoate. As a result, we isolated two novel C(30) carotenoids, hydroxy-3,4-dehydro-apo-8'-lycopene and methyl hydroxy-3,4-dehydro-apo-8'-lycopenoate, which were biosynthesized through a novel 8'-apo C(30) pathway. These carotenoids showed antioxidative activity in the (1)O(2) suppression model.
authors.affiliation: Department of Food and Nutrition, Japan Women's University, Mejirodai, Bunkyo-ku, Tokyo, Japan.
authors.forename: Ayako
authors.initials: A
authors.lastname: Osawa
authors.forename: Yoko
authors.initials: Y
authors.lastname: Ishii
authors.forename: Nao
authors.initials: N
authors.lastname: Sasamura
authors.forename: Marie
authors.initials: M
authors.lastname: Morita
authors.forename: Saskia
authors.initials: S
authors.lastname: Köcher
authors.forename: Volker
authors.initials: V
authors.lastname: Müller
authors.forename: Gerhard
authors.initials: G
authors.lastname: Sandmann
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Shindo
mesh_terms: D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology; D001406:Bacillaceae / Q000378:metabolism*; D002338:Carotenoids / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D000077276:Lycopene; D016296:Mutagenesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction / Q000187:drug effects
chemical_list: D000975:Antioxidants; C550682:hydroxy-3,4-dehydro-apo-8'-lycopene; C550683:methyl hydroxy-3,4-dehydro-apo-8'-lycopenoate; D002338:Carotenoids; D000077276:Lycopene