title: Translating animal doses of task-specific training to people with chronic stroke in 1-hour therapy sessions: a proof-of-concept study.
abstract: OBJECTIVE
  The purposes of this study were to (1) examine the feasibility of translating high-repetition doses of upper-extremity (UE) task-specific training to people with stroke within the confines of the current outpatient delivery system of 1-hour therapy sessions and (2) to gather preliminary data regarding the potential benefit of this intensity of training.
  
  
  METHODS
  A total of 15 patients with chronic (>6 months) UE paresis caused by stroke underwent 3 weeks of baseline assessments followed by 6 weeks of the high-repetition intervention (3 sessions/wk for 6 weeks). During each 1-hour session, participants were challenged to complete 300 or more repetitions of UE functional task training (3 tasks x 100 repetitions). Assessments during and after the intervention were used to measure feasibility and potential benefit.
  
  
  RESULTS
  For the 13 participants completing the intervention, the average number of repetitions per session was 322. The percentage of sessions attended was 97%. Participant ratings of pain and fatigue were low. Action Research Arm test scores improved an average of 8 points during the intervention and were maintained at the 1-month follow-up. Secondary measures of activity and participation increased, but the measure of impairment did not.
  
  
  CONCLUSIONS
  It is feasible to deliver hundreds of repetitions of task-specific training to people with stroke in 1-hour therapy sessions. Preliminary outcome data suggest that this intervention may be beneficial for some people with stroke.
authors.affiliation: Washington University, St. Louis, MO 63108, USA.
authors.forename: Rebecca L
authors.initials: RL
authors.lastname: Birkenmeier
authors.forename: Eliza M
authors.initials: EM
authors.lastname: Prager
authors.forename: Catherine E
authors.initials: CE
authors.lastname: Lang
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002908:Chronic Disease; D004195:Disease Models, Animal; D005081:Exercise Therapy / Q000009:adverse effects / Q000379:methods*; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D000071939:Stroke Rehabilitation; D013647:Task Performance and Analysis; D013663:Teaching / Q000379:methods*; D013997:Time Factors