[Application of polymer-based iodine-containing antiseptics to the surgical treatment of laryngeal cancer].
The objective of the present study was to accelerate the wound healing process following laryngectomy. Analysis of the treatment outcomes included 132 patients with stage III-IV laryngeal cancer. One group of patients (n=48) was treated with biocompatible polymer-based iodine-containing antiseptics (iodopor and iodopolikom) applied pre-, intra-, and post-operatively. The control group of 54 patients received traditional wound treatment following laryngectomy. The microbiological study demonstrated that the use of iodopolikom polymer-based antiseptic designed for cutaneous application allowed to reduce microbial colonization of the skin and to treat the postoperative wound without a dressing. Analysis of the results of local thermometry, cytological study, and wound tensiometry showed that polymer-based iodine-containing antiseptics reduce severity of local inflammatory reactions and stimulate regenerative processes in the wound after laryngoscopy. Wound healing by first intention in the group of patients treated by these preparations amounted to 81.2% compared with 55.6% in the control group.
Chistiakov
A L
AL
Klochikhin
A L
AL
D000287:Administration, Topical; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D006801:Humans; D007432:Intraoperative Period; D017613:Iodine Compounds / Q000008:administration & dosage*; D007822:Laryngeal Neoplasms / Q000601:surgery*; D007825:Laryngectomy; D011184:Postoperative Period; D057234:Preoperative Period; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014945:Wound Healing / Q000187:drug effects*
D000891:Anti-Infective Agents, Local; D017613:Iodine Compounds