title: [Study of components in xingnaojing affecting intestine absorption of gardenia extract].
abstract: OBJECTIVE
  To observe the influence of ingredients in Xingnaojing,such as moschus, borneol and radix curcumae on intestine absorption kinetics of gardenia extract.
  
  
  METHODS
  An in situ intestinal perfusion model of rats was employed to investigate the absorption of geniposide in gardenia extract.
  
  
  RESULTS
  While gardenia extract was administered solely, the absorptive rate constant (K) of geniposide was (0.055 +/- 0.006) h(-1); But while the extract was co-administered with radix curcumae,moschus and borneol, the K were (0.060 +/- 0.001), (0.066 +/- 0.008), (0.072 +/- 0.010) h(-1), respectively. The K was (0.076 +/- 0.011) h(-1) while the extract in total formulation for Xingnaojing.
  
  
  CONCLUSIONS
  The K, while the extract is co-administered with borneol or total formulation is significantly higher than solely used. Borneol and complex prescription can significantly increase the intestinal absorption of geniposide in gardenia extract.
authors.affiliation: School of Chinese Pharmacy, Beijing University of Traditional Chinese Medicine, Beijing 100102, China. dushouying@263.net
authors.forename: Shouying
authors.initials: S
authors.lastname: Du
authors.forename: Qianyi
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yang
authors.initials: Y
authors.lastname: Lu
authors.forename: Yongsong
authors.initials: Y
authors.lastname: Zhai
authors.forename: Qing
authors.initials: Q
authors.lastname: Wu
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D032062:Gardenia / Q000737:chemistry*; D007408:Intestinal Absorption / Q000187:drug effects*; D039823:Iridoids / Q000493:pharmacokinetics; D016014:Linear Models; D008297:Male; D010936:Plant Extracts / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar
chemical_list: D004365:Drugs, Chinese Herbal; D039823:Iridoids; D010936:Plant Extracts; C007835:geniposide