title: Innovative endodontic therapy for anti-inflammatory direct pulp capping of permanent teeth with a mature apex.
abstract: Direct pulp capping is treatment of an exposed vital pulp with a dental material to facilitate the formation of reparative dentin and maintenance of vital pulp. It has been studied as an alternate way to avoid vital pulp extirpation. However, the success rate of pulp capping is much lower than that of vital pulp extirpation. Therefore, direct pulp capping is currently considered controversial by many clinicians. To increase the success rate, a critical need exists to develop new biologically based therapeutics that reduce pulp inflammation, promote the continued formation of new dentin-pulp complex, and restore vitality by stimulating the regrowth of pulpal tissue. Bioengineered anti-inflammatory direct pulp-capping materials, together with adhesive materials for leakage prevention, have great potential to improve the condition of the existing pulp from an inflamed to a noninflamed status and lead to a high rate of long-term success.
authors.affiliation: Department of Endodontics, Texas A&M Health Science Center, Baylor College of Dentistry, Dallas, TX, USA. tkomabayashi@bcd.tamhsc.edu
authors.forename: Takashi
authors.initials: T
authors.lastname: Komabayashi
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zhu
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003763:Dental Leakage / Q000517:prevention & control; D003764:Dental Materials / Q000627:therapeutic use; D003782:Dental Pulp / Q000502:physiology; D003785:Dental Pulp Capping / Q000379:methods*; D003788:Dental Pulp Diseases / Q000209:etiology / Q000628:therapy; D003804:Dentin / Q000502:physiology; D006801:Humans; D011671:Pulpitis / Q000517:prevention & control*; D012390:Root Canal Therapy / Q000379:methods*; D019227:Tooth Apex / Q000502:physiology*; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D003764:Dental Materials