title: Association of Health Aging and Body Composition (ABC) Heart Failure score with cardiac structural and functional abnormalities in young individuals.
abstract: BACKGROUND
  The Health ABC Heart Failure score has recently been shown to predict 5-year risk of incident heart failure in the elderly. We tested whether this risk score is associated with subclinical phenotypes of heart failure in a younger population.
  
  
  METHODS
  We stratified participants in the Dallas Heart Study aged 30 to 65 years who had a cardiac magnetic resonance imaging and no self-reported history of heart failure or cardiomyopathy into 4 previously defined Health ABC Heart Failure risk groups: low (<5%), average (5%-10%), high (10%-20%), and very high (>20% risk for heart failure within 5 years). We compared left ventricular (LV) structural and functional parameters and levels of B-type natriuretic peptide (BNP) and N-terminal proBNP among the 4 groups.
  
  
  RESULTS
  In the study cohort (N = 2,540), the percentage of subjects in the low-, average-, high-, and very high risk groups was 78%, 15%, 6%, and 1%, respectively. Indexed LV mass (80 +/- 15 vs 90 +/- 20 vs 95 +/- 25 vs 116 +/- 41 g/m(2)), concentricity (1.6 +/- 0.3 vs 1.8 +/- 0.4 vs 2.0 +/- 0.5 vs 2.2 +/- 0.7 g/mL), median BNP (2.8 vs 3.7 vs 4.9 vs 7.5 pg/mL) and N-terminal proBNP (26 vs 30 vs 40 vs 58 pg/mL), and prevalent LV systolic dysfunction and LV hypertrophy progressively increased across risk groups (P < .001 for all) independent of gender or method of indexing LV mass.
  
  
  CONCLUSIONS
  The Health ABC Heart Failure score was associated with subclinical cardiac structural changes in the general population 30 to 65 years of age, suggesting that it may be a valid tool for identification of young individuals at increased risk for heart failure.
authors.affiliation: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390-9047, USA.
authors.forename: Sachin
authors.initials: S
authors.lastname: Gupta
authors.forename: Jarett D
authors.initials: JD
authors.lastname: Berry
authors.forename: Colby R
authors.initials: CR
authors.lastname: Ayers
authors.forename: Susan A
authors.initials: SA
authors.lastname: Matulevicius
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Peshock
authors.forename: Parag C
authors.initials: PC
authors.lastname: Patel
authors.forename: David W
authors.initials: DW
authors.lastname: Markham
authors.forename: Mark H
authors.initials: MH
authors.lastname: Drazner
mesh_terms: D000328:Adult; D001741:Black or African American / Q000706:statistics & numerical data; D000368:Aged; D001823:Body Composition; D003430:Cross-Sectional Studies; D005260:Female; D006305:Health Status Indicators; D006333:Heart Failure / Q000453:epidemiology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000453:epidemiology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011379:Prognosis; D018570:Risk Assessment; D012737:Sex Factors; D018487:Ventricular Dysfunction, Left / Q000097:blood / Q000453:epidemiology*; D016277:Ventricular Function, Left
chemical_list: D020097:Natriuretic Peptide, Brain