title: Site-specific functionalisation of proteins by a Staudinger-type reaction using unsymmetrical phosphites.
abstract: Unsymmetrical phosphites react efficiently in a Staudinger reaction with p-azido-phenylalanine, which can be applied for the biotinylation of proteins, thereby expanding the scope of the chemoselective Staudinger-phosphite reaction of aryl azides with symmetrical phosphites to the corresponding phosphoramidates.
authors.affiliation: Institut für Chemie und Biochemie, Freie Universität Berlin, Takustr. 3, 14195 Berlin, Germany.
authors.forename: Verena
authors.initials: V
authors.lastname: Böhrsch
authors.forename: Remigiusz
authors.initials: R
authors.lastname: Serwa
authors.forename: Paul
authors.initials: P
authors.lastname: Majkut
authors.forename: Eberhard
authors.initials: E
authors.lastname: Krause
authors.forename: Christian P R
authors.initials: CP
authors.lastname: Hackenberger
mesh_terms: D001386:Azides / Q000737:chemistry*; D019921:Biotinylation; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry; D017905:Phosphites / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*
chemical_list: D001386:Azides; D017905:Phosphites; D011506:Proteins; C027162:4-azidophenylalanine; D010649:Phenylalanine