Acute HIV infections among men with genital ulcer disease in South Africa.
We investigated acute human immunodeficiency virus (HIV) infection among men enrolled in a genital ulcer treatment trial in South Africa. HIV-negative participants were tested at baseline by HIV RNA polymerase chain reaction and followed up after 1 month to measure HIV seroconversion. There were 228 HIV-negative men at baseline; 10 were positive for HIV RNA, and 8 seroconverted to HIV at day 28. The prevalence of acute HIV among HIV-negative men at baseline was 18 (7.9%) of 228 men (95% confidence interval [CI], 4.4-11.4) and 18 (2.9%) of 615 men (95% CI, 1.6-4.3) in the overall study population. These data highlight the importance of genital ulcer patients in HIV transmission. Trial Registration. ClinicalTrials.gov identifier: NCT00164424 .
Paz Bailey
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Del Valle University of Guatemala and Centers for Disease Control and Prevention Collaboration, Guatemala City, Guatemala. gpaz@gt.cdc.gov
Sternberg
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M
Lewis
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DA
Puren
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A
D000328:Adult; D005837:Genitalia, Male / Q000473:pathology*; D015658:HIV Infections / Q000175:diagnosis / Q000453:epidemiology*; D006679:HIV Seropositivity; D006801:Humans; D008297:Male; D015995:Prevalence; D012367:RNA, Viral / Q000097:blood; D013019:South Africa / Q000453:epidemiology; D014456:Ulcer / Q000150:complications* / Q000188:drug therapy / Q000453:epidemiology*
D012367:RNA, Viral