title: [Neutrophilic inflammation--indicative of asthma severity].
abstract: Our main aim in this study was to investigate the number of neutrophils at the bronchial mucosae level in patients diagnosed with bronchial asthma.
  
  
  METHODS
  We examined a number of 21 patients with different level of severity of asthma (according to GINA). Fragments of bronchial mucosae were obtained through fiberbronchoscopy, prepared for histological examination for performing the immune staining with anti-elastase antibodies.
  
  
  RESULTS
  We found significantly higher number of neutrophils at microscopic examination in the patients with severe asthma than in healthy subjects or mild asthma subjects (r = 0.79, p < 0.01).
  
  
  CONCLUSIONS
  The results of this study suggest that neutrophils can be considered a specific lesion in patients with severe bronchial asthma.
authors.affiliation: Universitatea de Medicină si Farmacie Gr. T. Popa, Iaşi.
authors.forename: Adriana
authors.initials: A
authors.lastname: Grigoraş
authors.forename: Constantin-Cristian
authors.initials: CC
authors.lastname: Grigoraş
authors.forename: Traian
authors.initials: T
authors.lastname: Mihaescus
authors.forename: Alina
authors.initials: A
authors.lastname: Floarea-Strat
authors.forename: Corina
authors.initials: C
authors.lastname: Andriescu
authors.forename: Coriolan
authors.initials: C
authors.lastname: Cotutiu
mesh_terms: D000328:Adult; D001249:Asthma / Q000276:immunology* / Q000473:pathology*; D015415:Biomarkers / Q000378:metabolism; D001706:Biopsy; D001999:Bronchoscopy; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology*; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers