title: Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan.
abstract: Ten penicillinase-producing Neisseria gonorrhoeae (PPNG) strains isolated from 2000 to 2008 were characterized by multilocus sequence typing, multiantigen sequence typing, and plasmid typing. Sequence analysis showed that 8 strains contained a TEM-1 beta-lactamase gene. However, two other genetically distinct PPNG strains, isolated in 2004 and 2008, each contained a TEM-135 beta-lactamase on different plasmids, a Toronto/Rio type R plasmid and an Asia type R plasmid, suggesting independent origins of these PPNG strains.
authors.affiliation: Department of Bacteriology I, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku, Tokyo 162-8640, Japan. ohnishi7@nih.go.jp
authors.forename: Makoto
authors.initials: M
authors.lastname: Ohnishi
authors.forename: Emi
authors.initials: E
authors.lastname: Ono
authors.forename: Ken
authors.initials: K
authors.lastname: Shimuta
authors.forename: Haruo
authors.initials: H
authors.lastname: Watanabe
authors.forename: Noboru
authors.initials: N
authors.lastname: Okamura
mesh_terms: D007564:Japan; D008969:Molecular Sequence Data; D009344:Neisseria gonorrhoeae / Q000201:enzymology* / Q000235:genetics; D010405:Penicillinase / Q000235:genetics*; D010957:Plasmids / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D010405:Penicillinase; D001618:beta-Lactamases