title: [Preparation of water-soluble chitosan solid dispersion of daidzein].
abstract: OBJECTIVE
  To enhance the dissolution rate of daidzein with solid dispersion technique.
  
  
  METHODS
  Solid dispersions were prepared by the solvent method using water-solubility chitosan as a hydrophilic carrier. DSC, IR and X-ray methods were used to verify the formation of solid dispersion.
  
  
  RESULTS
  Dissolution percentages of solid dispersions were more than 90 percent in the drug-carrier ratio of 1:5 and 1:9. But dissolution percentages of physical mixtures and pure drug were 40 and 38.4 percent respectively. Part of daidzein dispersed in solid dispersion in the form of microcrystalline.
  
  
  CONCLUSIONS
  Water-soluble chitosan solid dispersion can significantly increase dissolution rate of daidzein.
authors.affiliation: School of Pharmacy, South-central University For Nationalities, Wuhan 430074, China. geyuebin@mail.scuec.edu.cn
authors.forename: Yuebin
authors.initials: Y
authors.lastname: Ge
authors.forename: Xubin
authors.initials: X
authors.lastname: Wang
authors.forename: Weilin
authors.initials: W
authors.lastname: Guo
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Xie
mesh_terms: D002152:Calorimetry, Differential Scanning; D048271:Chitosan / Q000737:chemistry*; D007529:Isoflavones / Q000737:chemistry*; D012995:Solubility; D013055:Spectrophotometry, Infrared; D014867:Water / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D007529:Isoflavones; D014867:Water; C004742:daidzein; D048271:Chitosan