title: Outcome of 40 adults aged from 18 to 55 years with acute lymphoblastic leukemia treated with double-delayed intensification pediatric protocol.
abstract: Adolescents ALL have a better outcome when treated with pediatric protocol compared to adult protocol. We have tested the feasibility of pediatric protocol to treat 40 consecutive adults ALL. DFS and OS were 73±7%, and 72±7%, and were significantly longer in patients under 40 yo (81±9% vs 51±15%, p=0.05 [DFS] and 83±7.8% vs 45±15%, p=0.003 [OS], respectively) or cortico/chemo-sensitive (86±9% vs 36±16%, p=0.001 [DFS] and 95±4.4% vs 28±13%, p<0.0001 [OS]) than in other patients. Overall tolerance was acceptable. We have shown the feasibility of using this unmodified pediatric protocol to treat adult with ALL up to 40 years.
authors.affiliation: Département d'Hématologie Hôpital Hôtel Dieu, AP-HP and Université Pierre et Marie Curie, Paris, France.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Haïat
authors.forename: Zora
authors.initials: Z
authors.lastname: Marjanovic
authors.forename: Simona
authors.initials: S
authors.lastname: Lapusan
authors.forename: Anne
authors.initials: A
authors.lastname: Vekhoff
authors.forename: Bernard
authors.initials: B
authors.lastname: Rio
authors.forename: Elise
authors.initials: E
authors.lastname: Corre
authors.forename: Sophie
authors.initials: S
authors.lastname: Dimicoli
authors.forename: Pierre
authors.initials: P
authors.lastname: Hirsch
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Marie
authors.forename: Ollivier
authors.initials: O
authors.lastname: Legrand
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012008:Recurrence; D055815:Young Adult