Vitamin E ameliorates high dose trans-dehydrocrotonin-associated hepatic damage in mice.
trans-Dehydrocrotonin (t-DCTN), the diterpenoid from Croton cajucara Bentham, exhibits hypoglycemic and hypolipidemic activities, but in high doses is associated with a discrete hepatotoxicity. In the search for measures to mitigate this, pretreatment with the antioxidants N-acetylcysteine and vitamin E has been examined. Mice that received a high dose t-DCTN (100 mg/kg) manifested hepatic damage, as evidenced by significant elevations in serum ALT and AST, and hepatic GSH, and histological alterations, which could be obliterated by pretreatment with vitamin E, but not with N-acetylcysteine, possibly by creating an effective antioxidant balance.
Rabelo
Alana Fontales Lima
AF
Departament of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil.
Guedes
Marjorie Moreira
MM
Tomé
Adriana da Rocha
Ada R
Lima
Patricia Rodrigues
PR
Maciel
Maria Aparecida
MA
Lira
Silveria Regina de Sousa
SR
Carvalho
Ana Carla da Silva
AC
Santos
Flávia Almeida
FA
Rao
Vietla Satyanarayana
VS
D000111:Acetylcysteine / Q000494:pharmacology*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001219:Aspartate Aminotransferases / Q000097:blood; D002374:Catalase / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000201:enzymology / Q000517:prevention & control*; D045785:Diterpenes, Clerodane / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004347:Drug Interactions; D005978:Glutathione / Q000032:analysis; D006651:Histocytochemistry; D008297:Male; D051379:Mice; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D045785:Diterpenes, Clerodane; D017392:Thiobarbituric Acid Reactive Substances; C103060:dehydrocrotonin; D014810:Vitamin E; D002374:Catalase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; D000111:Acetylcysteine