Catalytic enantioselective Mannich-type reaction with beta-phenyl sulfonyl acetonitrile.
The organocatalytic addition of beta-phenyl sulfonyl acetonitrile 1 to either N-Boc-protected alpha-amido sulfones or imines allowed the synthesis of enantioenriched alpha-unsubstituted beta-amino nitriles through a Mannich-type reaction.
González
Pedro B
PB
Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastián, Spain.
Lopez
Rosa
R
Palomo
Claudio
C
D000097:Acetonitriles / Q000737:chemistry*; D002384:Catalysis; D007097:Imines / Q000737:chemistry; D009570:Nitriles / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013450:Sulfones / Q000737:chemistry*
D000097:Acetonitriles; D007097:Imines; D009570:Nitriles; D013450:Sulfones; C032159:acetonitrile