Janus kinase-3 dependent inflammatory responses in allergic asthma.
Allergic asthma is a chronic inflammatory condition of the lung characterized by reversible airway obstruction, high serum immunoglobulin (Ig) E levels, and chronic airway inflammation. A number of cells including mast cells, T cells, macrophages and dendritic cells play a role in the pathogenesis of the disease. Janus kinase (JAK)-3, a non-receptor protein tyrosine kinase, traditionally known to mediate cytokine signaling, also regulates functional responses of these cells. In this review the role of JAK-3 in regulating various pathogenic processes in allergic asthma is discussed. We propose that targeting JAK-3 is a rationale approach to control the inflammatory responses of multiple cell types responsible for the pathogenesis of allergic asthma.
Malaviya
Rama
R
Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA. malaviya@rci.rutgers.edu
Laskin
Debra L
DL
Malaviya
Ravi
R
D000818:Animals; D001249:Asthma / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology; D015195:Drug Design; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D053616:Janus Kinase 3 / Q000276:immunology* / Q000378:metabolism; D008168:Lung / Q000276:immunology* / Q000473:pathology; D016676:Macrophages, Alveolar / Q000276:immunology; D008407:Mast Cells / Q000276:immunology; D011014:Pneumonia; D020545:Respiratory Mucosa / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology
D007073:Immunoglobulin E; D053616:Janus Kinase 3