Food preservatives sodium benzoate and propionic acid and colorant curcumin suppress Th1-type immune response in vitro.
Food preservatives sodium benzoate and propionic acid and colorant curcumin are demonstrated to suppress in a dose-dependent manner Th1-type immune response in human peripheral blood mononuclear cells (PBMC) in vitro. Results show an anti-inflammatory property of compounds which however could shift the Th1-Th2-type immune balance towards Th2-type immunity.
Maier
Elisabeth
E
Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innsbruck, Austria.
Kurz
Katharina
K
Jenny
Marcel
M
Schennach
Harald
H
Ueberall
Florian
F
Fuchs
Dietmar
D
D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003474:Curcumin / Q000494:pharmacology*; D005505:Food Coloring Agents / Q000494:pharmacology*; D005520:Food Preservatives / Q000494:pharmacology*; D006801:Humans; D007166:Immunosuppressive Agents; D066298:In Vitro Techniques; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000378:metabolism; D008934:Mitogens / Q000494:pharmacology; D011422:Propionates / Q000494:pharmacology*; D020160:Sodium Benzoate / Q000494:pharmacology*; D018417:Th1 Cells / Q000737:chemistry / Q000187:drug effects* / Q000276:immunology*
D005505:Food Coloring Agents; D005520:Food Preservatives; D007166:Immunosuppressive Agents; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D008934:Mitogens; D011422:Propionates; D003474:Curcumin; C029658:propionic acid; D020160:Sodium Benzoate