title: Asymmetric synthesis of spiro-3,4-dihydropyrans via a domino organocatalytic sequence.
abstract: A cinchona alkaloid-catalyzed domino Michael/hemiacetalization reaction of cyclic beta-oxo aldehydes and aromatic beta,gamma-unsaturated alpha-keto esters, resulting in the formation of spiro-dihydropyran architectures in good yield with high stereoselectivity (up to 97% ee), is presented.
authors.affiliation: Department of Chemistry, Zhejiang University, 20 Yugu Road, Hangzhou 310027, People's Republic of China.
authors.forename: Weijun
authors.initials: W
authors.lastname: Yao
authors.forename: Lianjie
authors.initials: L
authors.lastname: Pan
authors.forename: Yihua
authors.initials: Y
authors.lastname: Wu
authors.forename: Cheng
authors.initials: C
authors.lastname: Ma
mesh_terms: D002384:Catalysis; D002930:Cinchona Alkaloids / Q000737:chemistry*; D015394:Molecular Structure; D011714:Pyrans / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D002930:Cinchona Alkaloids; D011714:Pyrans; D013141:Spiro Compounds; C073813:3,4-dihydropyran