title: Inheritance of Schistosoma mansoni infection incompatibility in Biomphalaria alexandrina snails.
abstract: In this study, we looked at the inheritance of susceptibility and resistance to Schistosoma mansoni infection in the first generation of crossbred Biomphalaria alexandrina snails. Our ultimate goal is to use such information to develop a biological method of controlling schistosomiasis. We infected laboratory-bred snails with S. mansoni miracidia and examined cercarial shedding to determine susceptibility and resistance. Five parental groups were used: Group I contained 30 susceptible snails, Group II contained 30 resistant snails, Group III contained 15 susceptible and 15 resistant snails, Group IV contained 27 susceptible and three resistant snails and Group V contained three susceptible and 27 resistant snails. The percentage of resistant snails in the resulting progeny varied according to the ratio of susceptible and resistant parents per group; they are 7%, 100%, 68%, 45% and 97% from Groups I, II, III, IV and V, respectively. On increasing the percentage of resistant parent snails, the percentage of resistant progeny increased, while cercarial production in their susceptible progeny decreased.
authors.affiliation: Department of Parasitology, Faculty of Medicine, Alexandria University, Alexandria, Egypt. imanabouelnaga@hotmail.com
authors.forename: Iman F Abou
authors.initials: IF
authors.lastname: El Naga
authors.forename: Maha M
authors.initials: MM
authors.lastname: Eissa
authors.forename: Shereen F
authors.initials: SF
authors.lastname: Mossallam
authors.forename: Safaa I Abd
authors.initials: SI
authors.lastname: El-Halim
mesh_terms: D000818:Animals; D001700:Biomphalaria / Q000235:genetics / Q000469:parasitology*; D003433:Crosses, Genetic; D004198:Disease Susceptibility; D005260:Female; D006790:Host-Parasite Interactions / Q000235:genetics*; D008297:Male; D012550:Schistosoma mansoni / Q000472:pathogenicity / Q000502:physiology*; D012555:Schistosomiasis mansoni / Q000235:genetics*