title: Absence of evidence for MHC-dependent mate selection within HapMap populations.
abstract: The major histocompatibility complex (MHC) of immunity genes has been reported to influence mate choice in vertebrates, and a recent study presented genetic evidence for this effect in humans. Specifically, greater dissimilarity at the MHC locus was reported for European-American mates (parents in HapMap Phase 2 trios) than for non-mates. Here we show that the results depend on a few extreme data points, are not robust to conservative changes in the analysis procedure, and cannot be reproduced in an equivalent but independent set of European-American mates. Although some evidence suggests an avoidance of extreme MHC similarity between mates, rather than a preference for dissimilarity, limited sample sizes preclude a rigorous investigation. In summary, fine-scale molecular-genetic data do not conclusively support the hypothesis that mate selection in humans is influenced by the MHC locus.
authors.affiliation: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, United States of America.
authors.forename: Adnan
authors.initials: A
authors.lastname: Derti
authors.forename: Can
authors.initials: C
authors.lastname: Cenik
authors.forename: Peter
authors.initials: P
authors.lastname: Kraft
authors.forename: Frederick P
authors.initials: FP
authors.lastname: Roth
mesh_terms: D005260:Female; D005828:Genetics, Population; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008297:Male; D008393:Marriage