title: Two new hetero-spirocyclic gamma-lactam derivatives from marine sediment-derived fungus Aspergillus sydowi D2-6.
abstract: Two new hetero-spirocyclic gamma-lactams, azaspirofurans A (1) and B (2), had been isolated from a marine sediment-derived fungus Aspergillus sydowi D2-6. Their structures were determined by the chemical evidence and spectral analyses. Compound 1 exhibited cytotoxicity against A549 cell line with the IC50 value of 10 microM by MTT method.
authors.affiliation: Key Laboratory of Marine Drugs, Chinese Ministry of Education, Institute of Marine Drugs and Food, Ocean University of China, Qingdao, 266003, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Ren
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Chen
authors.forename: Tianjiao
authors.initials: T
authors.lastname: Zhu
authors.forename: Wei Ming
authors.initials: WM
authors.lastname: Zhu
authors.forename: Qian Qun
authors.initials: QQ
authors.lastname: Gu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D019015:Geologic Sediments / Q000382:microbiology*; D006801:Humans; D020128:Inhibitory Concentration 50; D007769:Lactams / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000302:isolation & purification* / Q000494:pharmacology; D013141:Spiro Compounds / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D007769:Lactams; D011760:Pyrrolidinones; D013141:Spiro Compounds; C551316:azaspirofuran A; C551317:azaspirofuran B