[Clinical significance of SKP2 and MRP-1/CD9 expression in glottic carcinoma and adjacent tissues].
OBJECTIVE
To study the expression of SKP2 and MRP-1/CD9 protein in glottic cancer and adjacent tissues, and to analyze its significance for a safe surgical margin.


METHODS
Thirty-eight cases of glottic squamous cell carcinoma were studied for its cancer tissue, tissue 2 mm, 5 mm, and 10 mm away from cancer, and 10 cases of vocal cord polyp were served as control. SKP2 and MRP-1/CD9 protein were examined by immunohistochemical method.


RESULTS
The positive expression of SKP2 proteins decreased in sequence of polyp mucosa, those adjacent to carcinoma (10 mm, 5 mm, 2 mm ) and cancer tissue, and there was significant difference between them (P < 0.05); On the contrary, the positive expression of the MRP-1/CD9 proteins increased in sequence of polypous mucosa, those adjacent to carcinoma (10 mm, 5 mm, 2 mm) and cancer tissue,and there was significant difference between them (P < 0.05).


CONCLUSIONS
SKP2 and MRP-1/CD may act as the reference index for judging the biological specialty of LSCC. It is appropriate to regard 5 mm or above 5 mm away from tumors as a safe margin for surgical treatment of glottic carcinoma.
Wang
Yan
Y
Department of Otorhinolaryngology, the Affiliated Hospital of Medical College of Qingdao University, Qingdao, 266003, China.
Sun
Yan
Y
Sun
Wenhai
W
Chen
Zhijun
Z
An
Fengmiao
F
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism*; D005260:Female; D005931:Glottis / Q000473:pathology*; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D018307:Neoplasms, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D044786:S-Phase Kinase-Associated Proteins / Q000378:metabolism*; D060245:Tetraspanin 29
D015703:Antigens, CD; C554869:CD9 protein, human; D008562:Membrane Glycoproteins; D044786:S-Phase Kinase-Associated Proteins; D060245:Tetraspanin 29