Lipoprotein (a), birth weight and neonatal stroke.
BACKGROUND
Elevated lipoprotein (Lp) (a) is the most common genetically determined risk factor found in babies with perinatal ischemic stroke. The influence of maternal Lp(a) has not been studied extensively to date.


OBJECTIVE
To investigate the role of Lp(a) in our population of neonates with stroke.


METHODS
In a prospective uncontrolled cohort of term-born children with neonatal arterial ischemic stroke, Lp(a) levels were investigated in 69 mothers and 69 children. Paternal Lp(a) was not explored.


RESULTS
An increased Lp(a) level was found in 26 mothers [38%; 95% confidence interval (CI) 28-50%] and in 15 children (22%; 95% CI 13-33%). Both rates were higher than the reference range reported in the general Caucasian population (10% in adults and 5% in children). Additionally, there was a correlation between maternal and infantile Lp(a) levels (p < 0.0001) and between elevated maternal Lp(a) level and lower birth weight (p = 0.027).


CONCLUSIONS
Elevated maternal Lp(a) is apparently a risk factor for neonatal arterial ischemic stroke. We speculate that the pathological mechanism of this relation may be mediated through a dysfunction of the placental vascularization.
Renaud
Cyrille
C
Groupe de recherche sur la thrombose, EA 3065, Université Saint-Etienne, Saint-Etienne, France.
Bonneau
Christine
C
Presles
Emilie
E
Laporte
Silvy
S
Depeyre
Arnaud
A
Varlet
Marie-Noëlle
MN
Chabrier
Stéphane
S
D001724:Birth Weight / Q000502:physiology*; D016022:Case-Control Studies; D015331:Cohort Studies; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000209:etiology* / Q000401:mortality; D017270:Lipoprotein(a) / Q000097:blood*; D009034:Mother-Child Relations; D009035:Mothers; D012307:Risk Factors; D020521:Stroke / Q000097:blood / Q000209:etiology* / Q000401:mortality
D017270:Lipoprotein(a)