Ruthenium/TFA-catalyzed regioselective C-3-alkylation of indoles with terminal alkynes in water: efficient and unprecedented access to 3-(1-methylalkyl)-1H-indoles.
An unprecedented C-3-alkylation reaction of indoles with terminal alkynes in aqueous medium has been developed using catalytic amounts of ruthenium and trifluoroacetic acid.
Cadierno
Victorio
V
Departamento de Química Orgánica e Inorgánica, IUQOEM, University of Oviedo, E-33006 Oviedo, Spain. vcm@uniovi.es
Francos
Javier
J
Gimeno
José
J
D000478:Alkylation; D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism; D014269:Trifluoroacetic Acid / Q000737:chemistry; D014867:Water / Q000737:chemistry
D000480:Alkynes; D007211:Indoles; D014867:Water; D012428:Ruthenium; D014269:Trifluoroacetic Acid