title: The association between metabolic syndrome and infarct size in patients with acute myocardial infarction.
abstract: BACKGROUND
  In patients with the metabolic syndrome, the prevalence of cardiovascular disease, disease-related morbidity and mortality are reported to be significantly higher than in a population without the metabolic syndrome. We investigated the role of metabolic syndrome and related biomarkers as predictors of infarct size in patients with their first myocardial infarction.
  
  
  METHODS
  This was a cross-sectional sub-study from the 3 months follow-up in the NORwegian Study of DIstrict treatment of ST-Elevation Myocardial Infarction (NORDISTEMI), including 152 consecutive patients, all initially treated with thrombolysis. Infarct size after 3 months was determined by late gadolinium enhanced magnetic resonance imaging, measuring ventricular infarct volume in absolute and relative terms.
  
  
  RESULTS
  At 3 months, 33 patients (22%) were categorized as having metabolic syndrome. There was no significant difference in median infarct size between those presenting with and without the metabolic syndrome [relative infarct volume 9.0 (4.8, 15.1) % vs. 8.3 (2.9, 13.6)%, p = 0.34]. Adjusting for possible confounders did not alter the results essentially. Circulating levels of IL-18, CRP and PAI-I activity were significantly higher in patients with the metabolic syndrome while adiponectin concentrations were significantly lower (p < or = 0.01 for all). None of these variables were associated with myocardial infarct size.
  
  
  CONCLUSIONS
  No association between the presence of metabolic syndrome and related biomarkers, and the size of the myocardial infarction was apparent in this study population.
authors.affiliation: Oslo University Hospital, Ulleval, Department of Cardiology, Oslo, Norway. ellen.bohmer@sykehuset-innlandet.no
authors.forename: Ellen
authors.initials: E
authors.lastname: Bøhmer
authors.forename: Ingebjørg
authors.initials: I
authors.lastname: Seljeflot
authors.forename: Harald
authors.initials: H
authors.lastname: Arnesen
authors.forename: Pavel
authors.initials: P
authors.lastname: Hoffmann
authors.forename: Michael
authors.initials: M
authors.lastname: Abdelnoor
authors.forename: Sigrun
authors.initials: S
authors.lastname: Halvorsen
mesh_terms: D052242:Adiponectin / Q000097:blood; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood; D008279:Magnetic Resonance Imaging; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications* / Q000453:epidemiology; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000150:complications* / Q000473:pathology; D012720:Severity of Illness Index
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D020382:Interleukin-18