title: The natural diatomite from caldiran-van (Turkey): electroanalytical application to antimigraine compound naratriptan at modified carbon paste electrode.
abstract: This paper is the first report describing the characterization of local diatomite of Caldiran-Van region (Eastern Anatolia, Turkey). Special attention was paid to the ability of its electroanalytical performance at modified electrodes and to the potential application of diatomite-modified electrode. For this purpose, the determination of Naratriptan which is a novel oral triptan (5-hydroxytryptamine receptor agonist) in migraine treatment, by means of a carbon paste electrode modified with 10% (w/w) of diatomite was studied using cyclic and square-wave voltammetry. The experimental conditions that affect the electrode reaction process were studied in terms of pH of the supporting electrolyte, scan rate, accumulation variables, modifier composition and square-wave parameters. Using square-wave stripping mode, the drug yielded a well-defined voltammetric response in Britton-Robinson buffer, pH 4.0 at 0.84 V (vs. Ag/AgCl) (a pre-concentration step being carried out with an open circuit at 120 s). The process could be used to determine Naratriptan concentrations in the range 5x10(-7)-9x10(-7) M, with a detection limit of 1.25x10(-7) M (46.5 mug L(-1)). The applicability of the method to spiked human urine samples was illustrated.
authors.affiliation: Department of Physical Chemistry, Yüzüncü Yil University, Van, Turkey.
authors.forename: Necla
authors.initials: N
authors.lastname: Calışkan
authors.forename: Eda
authors.initials: E
authors.lastname: Sögüt
authors.forename: Cafer
authors.initials: C
authors.lastname: Saka
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Yardım
authors.forename: Zuhre
authors.initials: Z
authors.lastname: Sentürk
mesh_terms: D002244:Carbon / Q000737:chemistry*; D007692:Diatomaceous Earth / Q000032:analysis*; D004563:Electrochemistry; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D010880:Piperidines / Q000032:analysis*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014363:Tryptamines / Q000032:analysis*; D014421:Turkey
chemical_list: D010880:Piperidines; D014363:Tryptamines; D007692:Diatomaceous Earth; C033787:diatomite; D002244:Carbon; C106783:naratriptan