Computational investigation and synthesis of a sol-gel imprinted material for sensing application of some biologically active molecules.
A hybrid sol-gel material was molecularly imprinted with a group of neurotransmitters. Imprinted material is a sol-gel thin film that is spin coated on the surface of a glassy carbon electrode. Imprinted films were characterized electrochemically using cyclic voltammetry (CV) and the encapsulated molecules were extracted from the films and complementary molecular cavities are formed that enable their rebind. The films were tested in their corresponding template solutions for rebinding using square wave voltammetry (SWV). Computational approach for exploring the primary intermolecular forces between templates and hydrolyzed form of the precursor monomer, tetraethylorthosilicate (TEOS), were carried out using Hartree-Fock method (HF). Interaction energy values were computed for each adduct formed between a monomer and a template. Analysis of the optimized conformations of various adducts could explain the mode of interaction between the templates and the monomer units. We found that interaction via the amino group is the common mode among the studied compounds and the results are in good agreement with the electrochemical measurements.
Atta
Nada F
NF
Department of Chemistry, Faculty of Science, University of Cairo, Post Code 12613, Giza, Egypt. Nada_fah1@yahoo.com
Hamed
Maher M
MM
Abdel-Mageed
Ali M
AM
D015374:Biosensing Techniques / Q000379:methods; D002244:Carbon / Q000737:chemistry; D055664:Electrochemical Techniques / Q000379:methods*; D004566:Electrodes; D005782:Gels / Q000737:chemistry*; D054802:Molecular Imprinting / Q000379:methods*; D018377:Neurotransmitter Agents / Q000032:analysis*; D012821:Silanes / Q000737:chemistry
D005782:Gels; D018377:Neurotransmitter Agents; D012821:Silanes; C040733:tetraethoxysilane; D002244:Carbon