title: One-pot procedure for the synthesis of unsymmetrical diarylalkynes.
abstract: Unsymmetrical diarylalkynes are accessible by a one-pot procedure from two different aryl halides and (trimethylsilyl)acetylene. The three-component coupling is initialized by a Pd/Cu-catalyzed Sonogashira coupling of an aryl halide with (trimethylsilyl)acetylene. After subsequent desilylation of the formed aryl(trimethylsilyl)acetylene with aqueous potassium hydroxide, a second Sonogashira coupling with an aryl iodide that does not require any additional Pd/Cu-catalyst gives access to an unsymmetrical diarylalkyne.
authors.affiliation: Institut für Reine und Angewandte Chemie, Universität Oldenburg, Carl-von-Ossietzky-Strasse 9-11, 26111 Oldenburg, Germany.
authors.forename: René
authors.initials: R
authors.lastname: Severin
authors.forename: Jessica
authors.initials: J
authors.lastname: Reimer
authors.forename: Sven
authors.initials: S
authors.lastname: Doye
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000480:Alkynes