[Cough-relieving, analgesic and antibiotic effects of durian shell extracts: a study in mice].
OBJECTIVE
To investigate the cough-relieving, analgesic and antibiotic effects of durian shell extract (DSE) in relieving cough and its analgesic and antibiotic effects.


METHODS
The effect of DSE in relieving cough was assessed in mice challenged with ammonia and SO(2) to induce coughing. The analgesic and antibiotic effects of DSE in mice were evaluated by hot plate test and twisting reaction induced by acetic acid, and by minimal inhibitory concentration (MIC) and disc-agar diffusion tests, respectively.


RESULTS
Compared with the control group, the mice treated with 300 and 900 mg/kg DSE showed significantly prolonged latency with decreased number of coughing induced by ammonia and SO(2), and the effect was dose-dependent. DSE markedly prolonged the latency and decreased the twisting number of the mice induced by acetic acid without affecting the pain threshold in hot plate test. DSE produced no significant inhibitory effects against Staphylococcus aureus, Staphylococcus epidermidis, or E. coli, and showed a week inhibition against Bacillus aeruginosus.


CONCLUSIONS
DSE shows obvious effect in relieving cough and produces better analgesic effect against chemical factor-induced pain than against physical agent-induced pain sensation. DSE has a moderate inhibitory effect against Bacillus aeruginosus.
Wu
Min-zhi
MZ
School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China. wmzzs@163.com
Xie
Guo
G
Li
Yong-xian
YX
Liao
Yan-feng
YF
Zhu
Rui
R
Lin
Ren-an
RA
Su
Yuan-bo
YB
Wu
Shu-guang
SG
Rao
Jin-jun
JJ
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000996:Antitussive Agents / Q000494:pharmacology*; D035161:Bombacaceae / Q000737:chemistry*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D011897:Random Allocation
D000700:Analgesics; D000900:Anti-Bacterial Agents; D000996:Antitussive Agents; D010936:Plant Extracts