The change of prefrontal QEEG theta cordance as a predictor of response to bupropion treatment in patients who had failed to respond to previous antidepressant treatments.
The aim of the study was to examine whether the reduction of theta prefrontal quantitative EEG (QEEG) cordance after one week of bupropion administration is a predictor of response to a 4-week treatment in patients that had failed to respond to previous antidepressant treatments.


METHODS
EEG data of 18 inpatients were monitored at baseline and after one week. QEEG cordance was computed at 3 frontal electrodes (Fp1, Fp2, Fz). Response to treatment was defined as a >/=50% reduction of MADRS score.


RESULTS
Nine of the eleven responders and one of the seven non-responders showed decreased prefrontal cordance value after the first week of treatment (p=0.01). Positive and negative predictive values of cordance reduction for the prediction of response to the treatment were 0.9 and 0.75, respectively.


CONCLUSIONS
Similar to other antidepressants, the reduction of prefrontal QEEG cordance might be helpful in the prediction of the acute outcome of bupropion treatment.
Bares
Martin
M
Prague Psychiatric Center, Ustavni 91, Prague 8-Bohnice, 181 03, Czech Republic. bares@pcp.lf3.cuni.cz
Brunovsky
Martin
M
Novak
Tomas
T
Kopecek
Miloslav
M
Stopkova
Pavla
P
Sos
Peter
P
Krajca
Vladimir
V
Höschl
Cyril
C
D000328:Adult; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016642:Bupropion / Q000494:pharmacology* / Q000627:therapeutic use; D003863:Depression / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D017397:Prefrontal Cortex / Q000187:drug effects / Q000503:physiopathology*; D018709:Statistics, Nonparametric; D013826:Theta Rhythm / Q000187:drug effects* / Q000379:methods
D000928:Antidepressive Agents; D016642:Bupropion