Cord blood and maternal serum neopterin concentrations in patients with pre-eclampsia.
BACKGROUND
Pre-eclampsia is a syndrome characterized by hypertension and proteinuria. The aim of this study was to investigate neopterin concentrations in cord blood and maternal serum in patients with pre-eclampsia and a control group.


METHODS
Cord blood and maternal serum neopterin were measured in 21 patients with pre-eclampsia and in 27 control subjects. Neopterin concentrations were measured by high performance liquid chromatography.


RESULTS
Cord blood neopterin concentrations were significantly increased in patients with pre-eclampsia compared to controls (54.3+/-16.8 vs. 43.4+/-8.5 nmol/L, p=0.011, respectively). Maternal serum neopterin (257.3+/-36.8 vs. 150.9+/-33.8 nmol/L, p<0.001) was also higher in patients with pre-eclampsia.


CONCLUSIONS
Cord blood and maternal serum neopterin concentrations are higher in patients with pre-eclampsia. Maternal serum neopterin concentrations used may be used as a marker for the early diagnosis of pre-eclampsia.
Cayci
Tuncer
T
Department of Medical Biochemistry, Gulhane Military Medical Academy, Ankara, Turkey.
Akgul
E Ozgur
EO
Kurt
Yasemin Gulcan
YG
Aydin
Ibrahim
I
Alacam
Hasan
H
Ozkan
Esin
E
Yaman
Halil
H
Cakir
Erdinc
E
Deren
Ozgur
O
Dogan
Pakize
P
Bilgi
Cumhur
C
Erbil
M Kemal
MK
D000328:Adult; D015415:Biomarkers / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D042241:Early Diagnosis; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D008431:Maternal-Fetal Exchange; D019798:Neopterin / Q000097:blood*; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011247:Pregnancy; D011296:Prenatal Diagnosis
D015415:Biomarkers; D019798:Neopterin