Explosive HIV-1 subtype B' epidemics in Asia driven by geographic and risk group founder events.
We explored the timescale, spatial spread, and risk group population structure of HIV-1 subtype B', the cause of explosive blood-borne HIV-1 epidemics among injecting drug users (IDUs) and former plasma donors (FPDs) in Asia. Sequences from FPDs in China formed a distinct monophyletic cluster within subtype B'. Further analysis revealed that subtype B' was founded by a single lineage of pandemic subtype B around 1985. Subsequently, the FPD cluster appears to have derived from a single subtype B' lineage around 1991, corroborating the hypothesis that FPD outbreaks stemmed from the preceding epidemic among IDUs in Southeast Asia, most likely from the Golden-Triangle region.
Li
Yue
Y
Laboratory of Molecular Virology and Epidemiology, AIDS Research Center, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Uenishi
Rie
R
Hase
Saiki
S
Liao
Huanan
H
Li
Xiao-Jie
XJ
Tsuchiura
Takayo
T
Tee
Kok Keng
KK
Pybus
Oliver G
OG
Takebe
Yutaka
Y
D001208:Asia / Q000453:epidemiology; D001782:Blood Donors; D016000:Cluster Analysis; D005838:Genotype; D005843:Geography; D015658:HIV Infections / Q000453:epidemiology* / Q000821:virology; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D017720:Molecular Epidemiology; D012367:RNA, Viral / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D012309:Risk-Taking; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D015819:Substance Abuse, Intravenous; D054301:gag Gene Products, Human Immunodeficiency Virus / Q000235:genetics
D012367:RNA, Viral; D054301:gag Gene Products, Human Immunodeficiency Virus