Amelioration of aminoglycoside nephrotoxicity requires protection of renal mitochondria.
Cytotoxic effects of some therapeutic drugs, including those used for antibacterial treatment, can involve mitochondria by inducing their permeabilization, followed by cell death and organ malfunctioning. This suggests that a strategy to preserve tissue mitochondria could preserve normal organ functioning. Morales et al. reveal that the antidiabetic drug metformin prevents gentamicin-induced nephropathy through a mitochondria-dependent pathway, normalizing oxidative stress and restoring mitochondrial functional integrity.
Zorov
Dmitry B
DB
Department of Bioenergetics, A.N. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, Russia. zorov@genebee.msu.su
D000617:Aminoglycosides / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology; D016923:Cell Death / Q000187:drug effects; D005839:Gentamicins / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000517:prevention & control*; D008687:Metformin / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D007004:Hypoglycemic Agents; D008687:Metformin