title: Repair of atrial septal defect with Eisenmenger syndrome after long-term sildenafil therapy.
abstract: We report a woman with atrial septal defect and severe pulmonary hypertension with 25.0 Wood unit.m(2) of indexed total pulmonary vascular resistance. She underwent successful corrective repair of atrial septal defect after 2 years of treatment with sildenafil, and has been monitored for 4 years after repair. This case supports a "treat and repair" approach using advanced pulmonary vasodilator therapy in selected patients with inoperable severe pulmonary hypertension associated with atrial septal defect.
authors.affiliation: Department of Pediatrics, College of Medicine, University of Ulsan, Seoul, Korea.
authors.forename: Young-Hwue
authors.initials: YH
authors.lastname: Kim
authors.forename: Jeong Jin
authors.initials: JJ
authors.lastname: Yu
authors.forename: Tae-Jin
authors.initials: TJ
authors.lastname: Yun
authors.forename: Yonghee
authors.initials: Y
authors.lastname: Lee
authors.forename: Yong Beom
authors.initials: YB
authors.lastname: Kim
authors.forename: Hyung Soon
authors.initials: HS
authors.lastname: Choi
authors.forename: Won Kyoung
authors.initials: WK
authors.lastname: Jhang
authors.forename: Hong Ju
authors.initials: HJ
authors.lastname: Shin
authors.forename: Jeong-Jun
authors.initials: JJ
authors.lastname: Park
authors.forename: Dong-Man
authors.initials: DM
authors.lastname: Seo
authors.forename: Jae-Kon
authors.initials: JK
authors.lastname: Ko
authors.forename: In-Sook
authors.initials: IS
authors.lastname: Park
mesh_terms: D000328:Adult; D006328:Cardiac Catheterization / Q000379:methods; D006348:Cardiac Surgical Procedures / Q000379:methods*; D018618:Echocardiography, Doppler, Color; D004541:Eisenmenger Complex / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006344:Heart Septal Defects, Atrial / Q000150:complications / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008134:Long-Term Care; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines / Q000627:therapeutic use; D018570:Risk Assessment; D012720:Severity of Illness Index; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000627:therapeutic use*; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate