title: Ampullary tumours (ampullomas) in the elderly--an interdisciplinary problem.
abstract: OBJECTIVE
  Ampullary cancer is one of the periampullary tumours with better prognosis, but relapses occur early in some patients. This study was carried out to assess whether pancreatoduodenectomy (PDE, Whipple operation) could be a safe therapeutic procedure for elderly patients with periampullary tumours.
  
  
  METHODS
  Between 2005 and 2007, 19 patients (12 male, 7 female) aged over 65 yr (range 66 and 83 yr) with diagnosis of ampulloma were operated.
  
  
  RESULTS
  Of the 19 patients, 6 underwent local surgical ampullectomy with reinsertion of ductus choledochus and Wirsungi's duct for benign or early cancer lesion and 13 underwent PDE (Whipple operation). Of these 13, only one was in T1 stage, one was in T4 stage, two patients were T3 and the rest in T2 stage. Lesion of lymphatic system had 40 per cent of patients in T2 stage and all in T3 and T4 stages. One patient died of pulmonary embolism several days after operation. Post-operative complications occurred in 3 cases: 1 patient with partial dehiscence of gastroenteroanastomosis - treated by conservative approach, 2 patients with dehiscence of pancreatojejunoanastomosis.
  
  
  CONCLUSIONS
  Diagnosis and therapy of ampullary tumours is multimodal. With careful patient selection, PDE can be performed in elderly people (>65 yr) safely. The post-operative morbidity in this group is essentially influenced by their multi-morbidity.
authors.affiliation: Department of Surgery, Masaryk University, Brno, Czech Republic.
authors.forename: Z
authors.initials: Z
authors.lastname: Kala
authors.forename: P
authors.initials: P
authors.lastname: Weber
authors.forename: B
authors.initials: B
authors.lastname: Hemmelová
authors.forename: F
authors.initials: F
authors.lastname: Marek
authors.forename: J
authors.initials: J
authors.lastname: Hlavsa
authors.forename: M
authors.initials: M
authors.lastname: Sobotka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014670:Ampulla of Vater / Q000473:pathology* / Q000601:surgery*; D003137:Common Bile Duct Diseases / Q000175:diagnosis* / Q000628:therapy*; D003138:Common Bile Duct Neoplasms / Q000601:surgery*; D013505:Digestive System Surgical Procedures / Q000379:methods; D004386:Duodenum / Q000601:surgery; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D012306:Risk; D016896:Treatment Outcome