A 41-year-old woman with von Hippel-Lindau and a cerebellar lesion.
A 41-year-old woman with a 12-year history of von Hippel-Lindau disease presented with progressive quadriparesis and difficulty swallowing. MRI revealed a well-circumscribed, partially cystic cerebellar neoplasm, consistent with hemangioblastoma. The tumor was resected and the diagnosis of hemangioblastoma confirmed. Embedded within the hemangioblastoma was a small focus of metastatic renal cell carcinoma (RCC). RCC metastatic to a CNS hemangioblastoma is the second most common type of tumor-to-tumor metastasis, which may be due to a number of factors. Proper immunostaining panels are required to clearly identify these cases since both tumor may have similar histology.
Martin
Sarah E
SE
Al-Khatib
Sohaib M
SM
Turner
Michael S
MS
Douglas-Akinwande
Annette C
AC
Hattab
Eyas M
EM
D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D018325:Hemangioblastoma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology; D008279:Magnetic Resonance Imaging; D006623:von Hippel-Lindau Disease / Q000175:diagnosis / Q000473:pathology*