title: The impact of beta2-microglobulin clearance on the risk factors of cardiovascular disease in hemodialysis patients.
abstract: beta2-Microglobulin (beta2M) is an independent predictor of outcome for hemodialysis (HD) patients and a representative substance of middle molecules. We tested the relationship among serum beta2M levels and cardiovascular disease (CVD) risk factors in HD patients. A total of 132 HD patients were divided according to the dialysis membrane used [property; cellulose and synthetic or beta2M clearance; low filtration (LF), middle filtration (MF), and high filtration (HF)]. There was no significant difference in CVD risk factors between cellulose and synthetic groups. On the other hand, serum beta2M, highly-sensitive C-reactive protein (hCRP), troponin-T (TnT), and myeloperoxidase (MPO) levels of LF were significantly higher and those of prealbumin (PA) were lower than the MF and HF. Serum beta2M level was positively correlated with hCRP, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), MPO, TnT, N-terminal pro-B-type natriuretic peptide (NT-proBNP) and inversely correlated with PA and ankle-brachial index (ABI). There was a significant correlation between serum beta2M levels and various CVD risk factors in HD. Cardiovascular disease risk factors in HD patients were dependent on the beta2M clearance but not membrane property.
authors.affiliation: Division of Nephrology and Dialysis, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan.
authors.forename: Takahiro
authors.initials: T
authors.lastname: Kuragano
authors.forename: Aritoshi
authors.initials: A
authors.lastname: Kida
authors.forename: Minoru
authors.initials: M
authors.lastname: Furuta
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Nanami
authors.forename: Yoshinaga
authors.initials: Y
authors.lastname: Otaki
authors.forename: Yukiko
authors.initials: Y
authors.lastname: Hasuike
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nonoguchi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakanishi
mesh_terms: D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D006435:Renal Dialysis / Q000009:adverse effects* / Q000295:instrumentation* / Q000379:methods; D012307:Risk Factors; D001613:beta 2-Microglobulin / Q000097:blood*
chemical_list: D001613:beta 2-Microglobulin