title: Lives saved by Global Fund-supported HIV/AIDS, tuberculosis and malaria programs: estimation approach and results between 2003 and end-2007.
abstract: BACKGROUND
  Since 2003, the Global Fund has supported the scale-up of HIV/AIDS, tuberculosis and malaria control in low- and middle-income countries. This paper presents and discusses a methodology for estimating the lives saved through selected service deliveries reported to the Global Fund.
  
  
  METHODS
  Global Fund-supported programs reported, by end-2007, 1.4 million HIV-infected persons on antiretroviral treatment (ARV), 3.3 million new smear-positive tuberculosis cases detected in DOTS (directly observed TB treatment, short course) programs, and 46 million insecticide-treated mosquito nets (ITNs) delivered. We estimated the corresponding lives saved using adaptations of existing epidemiological estimation models.
  
  
  RESULTS
  By end-2007, an estimated 681,000 lives (95% uncertainty range 619,000-774,000) were saved and 1,097,000 (993,000-1,249,000) life-years gained by ARV. DOTS treatment would have saved 1.63 million lives (1.09-2.17 million) when compared against no treatment, or 408,000 lives (265,000-551,000) when compared against non-DOTS treatment. ITN distributions in countries with stable endemic falciparum malaria were estimated to have achieved protection from malaria for 26 million of child-years at risk cumulatively, resulting in 130,000 (27,000-232,000) under-5 deaths prevented.
  
  
  CONCLUSIONS
  These results illustrate the scale of mortality effects that supported programs may have achieved in recent years, despite margins of uncertainty and covering only selected intervention components. Evidence-based evaluation of disease impact of the programs supported by the Global Fund with international and in-country partners must be strengthened using population-level data on intervention coverage and demographic outcomes, information on quality of services, and trends in disease burdens recorded in national health information systems.
authors.affiliation: The Global Fund to Fight AIDS, Tuberculosis and Malaria, Chemin Blandonnet 8, 1214 Vernier, Geneva, Switzerland. ryuichi.komatsu@theglobalfund.org
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Komatsu
authors.forename: Eline L
authors.initials: EL
authors.lastname: Korenromp
authors.forename: Daniel
authors.initials: D
authors.lastname: Low-Beer
authors.forename: Catherine
authors.initials: C
authors.lastname: Watt
authors.forename: Christopher
authors.initials: C
authors.lastname: Dye
authors.forename: Richard W
authors.initials: RW
authors.lastname: Steketee
authors.forename: Bernard L
authors.initials: BL
authors.lastname: Nahlen
authors.forename: Rob
authors.initials: R
authors.lastname: Lyerla
authors.forename: Jesus M
authors.initials: JM
authors.lastname: Garcia-Calleja
authors.forename: John
authors.initials: J
authors.lastname: Cutler
authors.forename: Bernhard
authors.initials: B
authors.lastname: Schwartländer
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D005260:Female; D005376:Financial Management; D006302:Health Services Research; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D057148:Insecticide-Treated Bednets; D008288:Malaria / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D014376:Tuberculosis / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality / Q000517:prevention & control*; D055815:Young Adult