title: Significance of hemoglobin concentration in determining blood CO2 binding capacity in critical illness.
abstract: This study was performed to provide simplified quantitative evidence of the impact of hemoglobin concentration on blood CO(2) binding and transport capacity. Linear regression equations were obtained for gas analyses data obtained from 85 surgical patients with sepsis and various degrees of illness. Venoarterial CO(2) concentration differences were calculated by a complex procedure, and then simplified equations were derived to highlight the impact of hemoglobin concentration on blood CO(2) binding and the Haldane effect. The results showed that, although in normal conditions the impact of hemoglobin concentration is less evident, it becomes relevant in extreme conditions, also protecting against venous and tissue hypercapnia and acidosis.
authors.affiliation: CNR-IASI Center for the Pathophysiology of Shock and Hepatobiliary Surgery Unit, Department of Surgery, Catholic University of the Sacred Heart School of Medicine, Largo Agostino Gemelli 8, I-00168 Rome, Italy.
authors.forename: Carlo
authors.initials: C
authors.lastname: Chiarla
authors.forename: Ivo
authors.initials: I
authors.lastname: Giovannini
authors.forename: Felice
authors.initials: F
authors.lastname: Giuliante
authors.forename: Maria
authors.initials: M
authors.lastname: Vellone
authors.forename: Francesco
authors.initials: F
authors.lastname: Ardito
authors.forename: Jyrki
authors.initials: J
authors.lastname: Tenhunen
authors.forename: Gennaro
authors.initials: G
authors.lastname: Nuzzo
mesh_terms: D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis / Q000379:methods; D002245:Carbon Dioxide / Q000097:blood*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007958:Leukocyte Count / Q000379:methods; D008297:Male; D008875:Middle Aged; D010108:Oxyhemoglobins / Q000378:metabolism; D012044:Regression Analysis; D012119:Respiration; D018805:Sepsis / Q000097:blood*
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; D002245:Carbon Dioxide