[Association of vascular endothelial growth factor 936C/T polymorphism and the susceptibility to colorectal adenoma].
OBJECTIVE
To examine the association between polymorphism of vascular endothelial growth factor(VEGF)1498 C/T,936 C/T and colorectal adenoma genetic susceptibility.


METHODS
A case-control study of 224 colorectal adenomas and 200 controls was conducted and VEGF genotypes were determined based on TaqMan-probe assay. The epidemiological factors were collected through questionnaire. Accordingly, the clinicopathological data of each sample were also investigated.


RESULTS
The carriage of 936 CT and CT+TT genotypes had significantly higher risk of colorectal adenoma (CT vs. CC, OR=2.00, 95% CI: 1.23-3.25, P=0.006; CT+TT vs. CC, OR=2.04, 95% CI:1.28-3.26, P=0.003). 936-T allele carriage had increased risk of colorectal adenoma (OR=1.91, 95% CI:1.25-2.91, P=0.003). The genotypes of 1498 C/T and the frequency of C/T allele showed no differences between healthy persons and patients (P>0.05). In patients with 936 CT+TT and 936-T allele implied a tendency of villous adenoma category (CT+TT vs. CC, OR=2.54, 95% CI:1.12-5.75, P=0.040; T allele vs. C allele, OR=3.08, 95% CI, 1.64-5.80, P=0.001).


CONCLUSIONS
VEGF 936 C/T polymorphism can influence susceptibility to colorectal adenoma.
Wu
Xiang-lei
XL
Department of General Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
Li
Dong-qing
DQ
Liu
Zhi-su
ZS
Wan
Xin-yue
XY
Wu
Yun-hua
YH
Jiang
Cong-qing
CQ
Zhang
Zhong-lin
ZL
Qin
Qian-bo
QB
Qian
Qun
Q
D000236:Adenoma / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A