title: [Expressions of interleukin 18 and prostaglandin E2 and their correlation in the synoviocytes of patients with osteoarthritis].
abstract: OBJECTIVE
  To explore the expression of interleukin 18 (IL-18) and prostaglandin E2 (PGE2) and their relationship in the synoviocytes of patients with osteoarthritis (OA).
  
  
  METHODS
  The synovial tissues were obtained from 30 OA patients to isolate the synoviocytes for primary culture. The concentrations of IL-18 and PGE2 in the supernatants of synoviocyte culture were measured by enzyme-linked immunosorbent assay (ELISA).
  
  
  RESULTS
  The concentration of IL-18 averaged 51.559-/+27.614 pg/ml and PGE2 327.036-/+333.561 pg/ml in the supernatant of the synoviocytes. A significant positive correlation was noted between their expressions (r=0.863, P<0.01).
  
  
  CONCLUSIONS
  IL-18 may induce the production of PGE2, and their interactions they may play an important role in the pathogenesis of OA.
authors.affiliation: Department of Spinal and Osteopathic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. wfl-1204@163.com
authors.forename: Feng-long
authors.initials: FL
authors.lastname: Wang
authors.forename: Jian-ming
authors.initials: JM
authors.lastname: Jiang
authors.forename: Fei
authors.initials: F
authors.lastname: Wang
authors.forename: Zhao-zong
authors.initials: ZZ
authors.lastname: Fu
authors.forename: Zhao-fei
authors.initials: ZF
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002478:Cells, Cultured; D015232:Dinoprostone / Q000378:metabolism*; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism* / Q000473:pathology; D013583:Synovial Membrane / Q000378:metabolism* / Q000473:pathology
chemical_list: D020382:Interleukin-18; D015232:Dinoprostone