title: ConPlex: a server for the evolutionary conservation analysis of protein complex structures.
abstract: Evolutionary conservation analyses are important for the identification of protein-protein interactions. For protein complex structures, sequence conservation has been applied to determine protein oligomerization states, to characterize native interfaces from non-specific crystal contacts, and to discriminate near-native structures from docking artifacts. However, a user-friendly web-based service for evolutionary conservation analysis of protein complexes has not been available. Therefore, we developed ConPlex (http://sbi.postech.ac.kr/ConPlex/) a web application that enables evolutionary conservation analyses of protein interactions within protein quaternary structures. Users provide protein complex structures; ConPlex automatically identifies protein interfaces and carries out evolutionary conservation analyses for the interface regions. Moreover, ConPlex allows the results of the residue-specific conservation analysis to be displayed on the protein complex structure and provides several options to customize the display output to fit each user's needs. We believe that ConPlex offers a convenient platform to analyze protein complex structures based on evolutionary conservation of protein-protein interface residues.
authors.affiliation: School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, Pohang, 790-784, Republic of Korea.
authors.forename: Yoon Sup
authors.initials: YS
authors.lastname: Choi
authors.forename: Seong Kyu
authors.initials: SK
authors.lastname: Han
authors.forename: Jinho
authors.initials: J
authors.lastname: Kim
authors.forename: Jae-Seong
authors.initials: JS
authors.lastname: Yang
authors.forename: Jouhyun
authors.initials: J
authors.lastname: Jeon
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Ryu
authors.forename: Sanguk
authors.initials: S
authors.lastname: Kim
mesh_terms: D003196:Computer Graphics; D019143:Evolution, Molecular; D020407:Internet; D046912:Multiprotein Complexes / Q000737:chemistry*; D020836:Protein Structure, Quaternary; D017386:Sequence Homology, Amino Acid; D012984:Software; D014584:User-Computer Interface
chemical_list: D046912:Multiprotein Complexes