Asymmetric dimethylarginine--a determinant of the effect of the high dose Simvastatin.
OBJECTIVE
Research of statins influence on flow induced vasodilatation reveals controversial results.


METHODS
We analyze whether asymmetric dimethylarginine (ADMA) levels influence the effect of 80mg/day simvastatin on flow-mediated vasodilation (%FMD). A total of 200 hypercholesterolemic patients were enrolled. Biochemistry parameters were examined by routine methods. Determination of %FMD was performed with software MedicaSoft. Patients were assigned into two groups according to the ADMA level.


RESULTS
Simvastatin, 80mg/day for 1month, resulted in changes in routine lipid profile and apolipoproteins, but there was not reduction of ADMA and homocysteine. In the group with ADMA<1.03micromol/L a significant increase of %FMD was observed, whereas no such was found in the group with ADMA>or=1.03micromol/L. %FMD-change correlated significant with baseline level of Apo-capital VE, Cyrillic and capital A, CyrillicDMA.


CONCLUSIONS
Asymmetric dimethylarginine level was found to determine the effect of high-dose simvastatin on %FMD.
Vladimirova-Kitova
Lyudmila G
LG
Clinic of Cardiology, University of Medicine, 2 Alexander Eksarch Str., 4000 Plovdiv, Bulgaria. kitov@vip.bg
Deneva-Koycheva
Tania
T
D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D019821:Simvastatin / Q000008:administration & dosage*; D014664:Vasodilation / Q000187:drug effects*
C487735:dimethylarginine; D001120:Arginine; D019821:Simvastatin