title: Elastic vesicles of sumatriptan succinate for transdermal administration: characterization and in vitro permeation studies.
abstract: Elastic liposomes, including sumatriptan succinate, were prepared for their transdermal administration. Lipid vesicles containing 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) or l-α-phosphatidylcholine dilauroyl (DLPC) phospholipids were characterized for various parameters, including size, particle-size distribution (i.e., polydispersity index), and elasticity. In vitro transdermal experiments for the study of the skin penetration of sumatriptan succinate contained in liposomes were performed by using flow-through diffusion cells. The diameter of sumatriptan liposomes with different lipid compositions varied between 279 and 282 nm, and the polydispersity index value for the size distribution of liposomal formulations was <0.5. DLPC vesicles proved to be more elastic and provided a higher sumatriptan transdermal flux than vesicles formulated with DOPC phospolipid.
authors.affiliation: Departamento de Fisiología, Farmacología y Toxicología, Facultad de Ciencias de la Salud, Universidad CEU Cardenal Herrera, Moncada, Spain. cbalaguer@uch.ceu.es
authors.forename: Cristina
authors.initials: C
authors.lastname: Balaguer-Fernández
authors.forename: Andres
authors.initials: A
authors.lastname: Femenía-Font
authors.forename: Virginia
authors.initials: V
authors.lastname: Merino
authors.forename: Damián
authors.initials: D
authors.lastname: Córdoba-Díaz
authors.forename: María A
authors.initials: MA
authors.lastname: Elorza-Barroeta
authors.forename: Alicia
authors.initials: A
authors.lastname: López-Castellano
authors.forename: Manuel
authors.initials: M
authors.lastname: Córdoba-Díaz
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D004548:Elasticity; D066298:In Vitro Techniques; D008081:Liposomes; D010316:Particle Size; D010539:Permeability; D012867:Skin / Q000378:metabolism; D018170:Sumatriptan / Q000008:administration & dosage*; D013552:Swine
chemical_list: D008081:Liposomes; D018170:Sumatriptan