title: [Cerebral hemisphere tumours in neurofibromatosis type 1 during childhood].
abstract: OBJECTIVE
  To present seven tumors of the cerebral hemispheres in 6 children with neurofibromatosis type 1 (NF1).
  
  
  METHODS
  Six patients (three males and three females) of 600 cases of a series with NF1 showed features of cerebral hemispheres tumor (seizures, headache and hemiparesis). They were studied neurologically, by EEG and by image (MR and/or spectroscopic-MR) because of these features or simply because having NF1.
  
  
  RESULTS
  All the patients had the two diagnostic criteria of the NF1. Six patients had seven tumors (it was because one of them had one tumor in every frontal lobe, both with the same image characteristics), but they did not were removed and they were not studied histologically. The histological study was made to the other five patients and showed that the histological nature corresponded to pilocytic astrocytoma in one patient, neuroepitelial dysembryoplastic tumor in one, polymorphe xanthoastrocytoma in one, neuroectodermic hamartoma in one, and inflammatory chronic non-granulomatose lesion in one.
  
  
  CONCLUSIONS
  The prevalence of the tumors in the cerebral hemispheres is very low (1%) in the patients with NF1. The tumors commonly are histologically benign, and they can be found in peripheral or deep region of the cerebral hemispheres. Identity of the tumors by MR study commonly is easy and the treatment is surgical in most cases. However, urgent treatment very seldom is necessary in these tumors, and most frequently is possible to take the attitude of 'wait and see' before to decide the definite treatment.
authors.affiliation: Servicio de Neurología Pediátrica, Hospital Universitario La Paz, Unidad de Imagen, Madrid, España. i.pcastroviejo@neurologia.e.telefonica.net
authors.forename: Ignacio
authors.initials: I
authors.lastname: Pascual-Castroviejo
authors.forename: Samuel Ignacio
authors.initials: SI
authors.lastname: Pascual-Pascual
authors.forename: Juan
authors.initials: J
authors.lastname: Viaño
authors.forename: Ramón
authors.initials: R
authors.lastname: Velázquez-Fragua
authors.forename: Fernando
authors.initials: F
authors.lastname: Carceller-Benito
authors.forename: Manuel
authors.initials: M
authors.lastname: Gutiérrez-Molina
authors.forename: Carmen
authors.initials: C
authors.lastname: Morales-Bastos
mesh_terms: D001932:Brain Neoplasms / Q000209:etiology / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications / Q000473:pathology*; D012189:Retrospective Studies