[Surgery for diabetes: challenge or reality?].
Bariatric surgery techniques can usually increase either sensitivity or insulin resistance, acting on three different levels: decrease of food intake, malabsorption and modifications of entero-insulaire axis activity. This latter is taken into account in order to develop a new protocol to obtain diabetes remission without important weight loss and nutritional deficiencies. Preliminary results are interesting but they come from very short time studies with few patients. Moreover, complications rate is at present very high. Knowing better gastrointestinal mechanisms of diabetes control and especially incretins role is absolutely necessary before identifying surgery as a true metabolic treatment.
Giusti
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Service d'endocrinologie, diabétologie et métabolisme, CHUV, 1011 Lausanne. vittorio.giusti@chuv.ch
D050110:Bariatric Surgery; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000517:prevention & control; D006801:Humans; D009765:Obesity / Q000150:complications* / Q000601:surgery*