title: Prevalence and patient characteristics associated with pleural tuberculosis in Nigeria.
abstract: BACKGROUND
  Tuberculosis is a leading cause of mortality worldwide, with a growing death rate. The pleural space is a common extrapulmonary site of involvement. The aim of this paper is to document prevalence and types of pleural involvement in pulmonary tuberculosis and patient characteristics associated with its occurrence.
  
  
  METHODS
  The study was conducted in a hospital outpatient clinic in which consecutive patients with pulmonary tuberculosis (PTB) or suspects were recruited and studied for the presence of co existing pleural disease or involvement (PD).
  
  
  RESULTS
  Of 100 patients studied, eighty-two (82%) had PTB alone and six (6%) patients had PD. Pleural effusion was responsible for the majority of the cases, accounting for 67% of PD. There was no case of empyema. Mean age between patients with PTB and PTB/PD was similar. On univariate analysis, patients with PD had a shorter duration of symptoms and increased reporting of fever (p value = 0.02) and were also different from those with only PTB in HIV seropositivity and sputum smear from AFB (p value = 0.02 and 0.00 respectively). However, after adjustment for multiple comparisons using the Bonferroni test, the only significant difference between them was in the HIV seropositivity rate (p value < 0.012).
  
  
  CONCLUSIONS
  Less than one tenth of patients with PTB have co-existing and involvement of the pleural space. Pleural involvement is associated with HIV.
authors.affiliation: Department of Medicine, Obafemi Awolowo Unversity Teaching Hospitals Complex, Ile Ife, Nigeria. adewolef@yahoo.co.uk
authors.forename: Olufemi O
authors.initials: OO
authors.lastname: Adewole
authors.forename: Greg E
authors.initials: GE
authors.lastname: Erhabor
authors.forename: Akinwumi B
authors.initials: AB
authors.lastname: Ogunrombi
authors.forename: Fehintola A
authors.initials: FA
authors.lastname: Awopeju
mesh_terms: D000328:Adult; D005260:Female; D015658:HIV Infections / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D014396:Tuberculosis, Pleural / Q000453:epidemiology* / Q000473:pathology*; D014397:Tuberculosis, Pulmonary / Q000150:complications*