title: Estimation of Eeg Signal Dispersion During Seizure Propagation.
abstract: Localization of the seizure focus in the brain is a challenging problem in the field of epilepsy. The complexity of the seizure-related EEG waveform, its non-stationarity and degradation with distance due to the dispersive nature of the brain as a propagation medium, make localization difficult. Yet, precise estimation of the focus is critical, particularly when surgical resection is the only therapeutic option. The first step to solving this inverse problem is to estimate and account for frequency- or mode-specific signal dispersion, which is present in both scalp and intracranial EEG recordings during seizures. We estimated dispersion curves in both types of signals using a spatial correlation method and mode-based semblance analysis. We showed that, despite the assumption of spatial stationarity and a simplified array geometry, there is measurable inter-modal and intra-modal dispersion during seizures in both types of EEG recordings, affecting the estimated arrival times and consequently focus localization.
authors.affiliation: Harvard Medical School, Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA.
authors.forename: Catherine
authors.initials: C
authors.lastname: Stamoulis
authors.forename: Bernard S
authors.initials: BS
authors.lastname: Chang
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Madsen