The role of parenteral nutrition in acute leukemia.
Patients with acute leukemia who undergo hematopoietic stem cell transplantation (HSCT) are susceptible to malnutrition caused by several factors including intensive cytotoxic therapy. This paper discusses the significance of malnutrition in these patients and provides an overview of nutrition therapy by the oral, enteral, and parenteral routes. The goal is to investigate whether the use of parenteral nutrition (PN) produces improved clinical outcomes in patients with acute leukemia and to identify criteria for the selection of patients most likely to benefit from this therapy. Although PN may be appropriate for patients suffering from complications such as graft-versus-host disease (GVHD) and mucositis, the data available at this time do not support PN as first-line therapy for all recipients of HSCT.
Jacobson
Nicole B
NB
Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Parekh
Neha
N
Kalaycio
Matt
M
D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004750:Enteral Nutrition; D005234:Fatty Liver / Q000209:etiology; D001068:Feeding and Eating Disorders / Q000150:complications; D005767:Gastrointestinal Diseases / Q000150:complications; D006086:Graft vs Host Disease / Q000150:complications; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007239:Infections / Q000150:complications; D007938:Leukemia / Q000150:complications* / Q000628:therapy; D044342:Malnutrition / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D052016:Mucositis / Q000150:complications; D009751:Nutritional Requirements; D010288:Parenteral Nutrition / Q000009:adverse effects; D011878:Radiotherapy / Q000009:adverse effects; D012307:Risk Factors
D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents