title: Glucose control in hospitalized patients.
abstract: Evidence indicates that hospitalized patients with hyperglycemia do not benefit from tight blood glucose control. Maintaining a blood glucose level of less than 180 mg per dL (9.99 mmol per L) will minimize symptoms of hyperglycemia and hypoglycemia without adversely affecting patient-oriented health outcomes. In the absence of modifying factors, physicians should continue patients' at-home diabetes mellitus medications and randomly check glucose levels once daily. Sulfonylureas should be withheld to avoid hypoglycemia in patients with limited caloric intake. Patients with cardiovascular conditions may benefit from temporarily stopping treatment with thiazolidinediones to avoid precipitating heart failure. Metformin should be temporarily withheld in patients who have worsening renal function or who will undergo an imaging study that uses contrast. When patients need to be treated with insulin in the short term, using a long-acting basal insulin combined with a short-acting insulin before meals (with the goal of keeping blood glucose less than 180 mg per dL) better approximates normal physiology and uses fewer nursing resources than sliding-scale insulin approaches. Most studies have found that infusion with glucose, insulin, and potassium does not improve mortality in patients with acute myocardial infarction. Patients admitted with acute myocardial infarction should have moderate control of blood glucose using home regimens or basal insulin with correctional doses.
authors.affiliation: Tufts University Family Medicine Residency at Cambridge Health Alliance, 195 Canal St., Malden, MA 02148, USA. gsawin@challiance.org
authors.forename: Gregory
authors.initials: G
authors.lastname: Sawin
authors.forename: Allen F
authors.initials: AF
authors.lastname: Shaughnessy
mesh_terms: D001786:Blood Glucose / Q000187:drug effects; D002985:Clinical Protocols; D048909:Diabetes Complications / Q000517:prevention & control*; D004334:Drug Administration Schedule; D006760:Hospitalization; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy* / Q000517:prevention & control; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D007297:Inpatients; D007328:Insulin / Q000008:administration & dosage*; D008991:Monitoring, Physiologic; D009203:Myocardial Infarction / Q000150:complications; D010043:Outcome and Process Assessment, Health Care; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin