title: Long-term physical activity and inflammatory biomarkers in older adults.
abstract: OBJECTIVE
  The purpose of this study was to determine the effects of a 12-month physical activity (PA) intervention on inflammatory biomarkers in elderly men and women.
  
  
  METHODS
  Four hundred and twenty-four elderly (age = 70-89 yr), nondisabled, community-dwelling men and women at risk for physical disability were enrolled in a multicenter, single-blind, randomized controlled trial. Participants were randomized to participate in either a 12-month moderate-intensity PA intervention or a successful aging health education intervention. Biomarkers of inflammation (interleukin (IL)-6sR, IL-1sRII, soluble tumor necrosis factor receptors 1 and 2 (sTNFRI, sTNFRII), IL-8, IL-15, adiponectin, IL-1ra, IL-2sRα, and TNFα) were measured at baseline, at 6 months, and at 12 months.
  
  
  RESULTS
  A baseline blood sample was successfully collected from 368 participants. After adjustment for gender, clinic site, diabetes status, and baseline outcome measure, IL-8 was the only inflammatory biomarker affected by the PA intervention (P = 0.03). The adjusted mean IL-8 at month 12 was 9.9% (0.87 pg·mL) lower in the PA compared with the successful aging group. Secondary interaction analyses between baseline biomarker status and treatment showed one significant interaction (P = 0.02) such that the PA intervention reduced IL-15 concentrations in participants with a baseline IL-15 above the median value of 1.67 pg·mL. However, these associations were no longer significant after consideration for multiple comparisons.
  
  
  CONCLUSIONS
  Overall, this study does not provide definitive evidence for an effect of regular exercise for altering systemic concentrations of the measured inflammatory biomarkers in older adults.
authors.affiliation: Section on Gerontology and Geriatric Medicine, J. Paul Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. kbeavers@wfubmc.edu
authors.forename: Kristen M
authors.initials: KM
authors.lastname: Beavers
authors.forename: Fang-Chi
authors.initials: FC
authors.lastname: Hsu
authors.forename: Scott
authors.initials: S
authors.lastname: Isom
authors.forename: Stephen B
authors.initials: SB
authors.lastname: Kritchevsky
authors.forename: Timothy
authors.initials: T
authors.lastname: Church
authors.forename: Bret
authors.initials: B
authors.lastname: Goodpaster
authors.forename: Marco
authors.initials: M
authors.lastname: Pahor
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Nicklas
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000378:metabolism; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood*; D016207:Cytokines / Q000097:blood / Q000378:metabolism; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D007378:Interleukins / Q000097:blood* / Q000378:metabolism; D008297:Male; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood* / Q000378:metabolism; D048069:Tumor Necrosis Factors / Q000097:blood* / Q000378:metabolism; D014481:United States
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D016207:Cytokines; D007378:Interleukins; D018124:Receptors, Tumor Necrosis Factor; D048069:Tumor Necrosis Factors