title: Square-wave voltammetric determination of propranolol and atenolol in pharmaceuticals using a boron-doped diamond electrode.
abstract: The independent determination of two beta-blocker agents, namely propranolol (PROP) and atenolol (ATN), in pharmaceutical formulations using square-wave voltammetry and a cathodically pretreated boron-doped diamond electrode is described. These electroanalytical determinations of propranolol or atenolol were carried out in 0.1molL(-1) H(2)SO(4) or 0.5molL(-1) NaNO(3) (pH 1.0, adjusted with concentrated HNO(3)), respectively. Excellent linear calibration curves, ranging from 0.20 to 9.0micromolL(-1) for PROP and from 2.0 to 41micromolL(-1) for ATN, with detection limits of 0.18 and 0.93micromolL(-1), respectively, were obtained. The obtained recoveries range from 93.9% to 105.0%, for PROP, and from 92.5% to 106.0%, for ATN. The proposed method was successfully applied in the determination of both beta-blockers in several pharmaceutical formulations (tablets), with results in close agreement at a 95% confidence level with those obtained using official spectrophotometric methods.
authors.affiliation: Departamento de Química, Universidade Federal de São Carlos, São Carlos, SP, Brazil.
authors.forename: Elen Romão
authors.initials: ER
authors.lastname: Sartori
authors.forename: Roberta Antigo
authors.initials: RA
authors.lastname: Medeiros
authors.forename: Romeu C
authors.initials: RC
authors.lastname: Rocha-Filho
authors.forename: Orlando
authors.initials: O
authors.lastname: Fatibello-Filho
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000032:analysis; D001262:Atenolol / Q000737:chemistry*; D001895:Boron / Q000737:chemistry*; D002623:Chemistry Techniques, Analytical; D002626:Chemistry, Pharmaceutical / Q000379:methods; D018130:Diamond / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods; D004566:Electrodes; D057230:Limit of Detection; D008956:Models, Chemical; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011199:Potentiometry; D011433:Propranolol / Q000737:chemistry*; D013607:Tablets
chemical_list: D000319:Adrenergic beta-Antagonists; D004364:Pharmaceutical Preparations; D013607:Tablets; D001262:Atenolol; D018130:Diamond; D011433:Propranolol; D001895:Boron