title: Cord blood and maternal serum neopterin concentrations in patients with pre-eclampsia.
abstract: BACKGROUND
  Pre-eclampsia is a syndrome characterized by hypertension and proteinuria. The aim of this study was to investigate neopterin concentrations in cord blood and maternal serum in patients with pre-eclampsia and a control group.
  
  
  METHODS
  Cord blood and maternal serum neopterin were measured in 21 patients with pre-eclampsia and in 27 control subjects. Neopterin concentrations were measured by high performance liquid chromatography.
  
  
  RESULTS
  Cord blood neopterin concentrations were significantly increased in patients with pre-eclampsia compared to controls (54.3+/-16.8 vs. 43.4+/-8.5 nmol/L, p=0.011, respectively). Maternal serum neopterin (257.3+/-36.8 vs. 150.9+/-33.8 nmol/L, p<0.001) was also higher in patients with pre-eclampsia.
  
  
  CONCLUSIONS
  Cord blood and maternal serum neopterin concentrations are higher in patients with pre-eclampsia. Maternal serum neopterin concentrations used may be used as a marker for the early diagnosis of pre-eclampsia.
authors.affiliation: Department of Medical Biochemistry, Gulhane Military Medical Academy, Ankara, Turkey.
authors.forename: Tuncer
authors.initials: T
authors.lastname: Cayci
authors.forename: E Ozgur
authors.initials: EO
authors.lastname: Akgul
authors.forename: Yasemin Gulcan
authors.initials: YG
authors.lastname: Kurt
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Aydin
authors.forename: Hasan
authors.initials: H
authors.lastname: Alacam
authors.forename: Esin
authors.initials: E
authors.lastname: Ozkan
authors.forename: Halil
authors.initials: H
authors.lastname: Yaman
authors.forename: Erdinc
authors.initials: E
authors.lastname: Cakir
authors.forename: Ozgur
authors.initials: O
authors.lastname: Deren
authors.forename: Pakize
authors.initials: P
authors.lastname: Dogan
authors.forename: Cumhur
authors.initials: C
authors.lastname: Bilgi
authors.forename: M Kemal
authors.initials: MK
authors.lastname: Erbil
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D042241:Early Diagnosis; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D008431:Maternal-Fetal Exchange; D019798:Neopterin / Q000097:blood*; D011225:Pre-Eclampsia / Q000175:diagnosis*; D011247:Pregnancy; D011296:Prenatal Diagnosis
chemical_list: D015415:Biomarkers; D019798:Neopterin