title: Efficacy of dual-source CT coronary angiography in evaluating coronary stenosis: initial experience.
abstract: OBJECTIVE
  To retrospectively assess the diagnostic efficacy of dual-source CT angiography (DSCTA) in detecting and grading coronary stenosis.
  
  
  METHODS
  Institutional review board approval and informed consent were obtained. One hundred ten patients were performed with both DSCTA and conventional coronary angiography (CCA) without heart rate or rhythm control in 1 week. Regarding CCA as the gold standard, the assessable rate of coronary arteries and diagnostic value of coronary stenosis using DSCTA were analyzed, respectively. The intermodality agreement between DSCTA and CCA in grading coronary stenosis was assessed using kappa test. The value of DSCTA in diagnosing >50% coronary stenoses was also assessed.
  
  
  RESULTS
  The overall assessable rate of DSCTA was 98.6% in detecting coronary arteries; there was no significant difference between assessable rates from different groups of heart rate (chi(2)=0.45, P > .05). The efficacy of DSCTA was of 97.9% sensitivity, 97.3% specificity, 90.4% positive predictive value, and 99.4% negative predictive value for coronary stenosis; and 94.7% sensitivity, 96.8% specificity, 83.7% positive predictive value, and 99% negative predictive value for >50% stenoses. The intermodality agreement in diagnosing coronary stenosis was satisfactory (k=0.87, u=58.46, P<.01).
  
  
  CONCLUSIONS
  As an effective noninvasive diagnostic tool, DSCTA yields a promising accuracy and reliability in assessing coronary stenosis. It may be recommended as a valuable screening tool for coronary artery disease, and a potential challenge to CCA as well.
authors.affiliation: Imaging Center, Wuxi People's Hospital, Nanjing Medical University, 214023, Wuxi City, Jiangsu Province, People's Republic of China.
authors.forename: Hong-wei
authors.initials: HW
authors.lastname: Chen
authors.forename: Xiang-ming
authors.initials: XM
authors.lastname: Fang
authors.forename: Xiao-yun
authors.initials: XY
authors.lastname: Hu
authors.forename: Jian
authors.initials: J
authors.lastname: Bao
authors.forename: Chun-hong
authors.initials: CH
authors.lastname: Hu
authors.forename: Yin
authors.initials: Y
authors.lastname: Chen
authors.forename: Zhen-yu
authors.initials: ZY
authors.lastname: Yang
authors.forename: Lerner
authors.initials: L
authors.lastname: Alexander
authors.forename: Xiao-qing
authors.initials: XQ
authors.lastname: Wu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017023:Coronary Angiography / Q000379:methods*; D023921:Coronary Stenosis / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*