title: High education may offer protection against tauopathy in patients with mild cognitive impairment.
abstract: The concepts of brain and cognitive reserve stem from the observation that premorbid factors (e.g., education) result in variation in the response to brain pathology. Potential early influence of reserve on pathology, as assessed using the cerebrospinal fluid biomarkers total tau (t-tau) and amyloid-beta42, and cognition was explored in mild cognitive impairment (MCI) patients who remained stable over a two-year period. A total of 102 patients with stable MCI grouped on the basis of educational level were compared with regard to biomarker concentrations and cognitive performance. Stable MCI patients with higher education had lower concentrations of t-tau as compared to those with lower education. Also, educational level predicted a significant proportion of the total variance in t-tau concentrations. Our results suggest that higher education may offer protection against tauopathy.
authors.affiliation: Institute of Neuroscience and Physiology, Section for Neurochemistry and Psychiatry, the Sahlgrenska Academy at Göteborg University, Mölndal, Sweden.
authors.forename: Sindre
authors.initials: S
authors.lastname: Rolstad
authors.forename: Arto
authors.initials: A
authors.lastname: Nordlund
authors.forename: Carl
authors.initials: C
authors.lastname: Eckerström
authors.forename: Marie H
authors.initials: MH
authors.lastname: Gustavsson
authors.forename: Kaj
authors.initials: K
authors.lastname: Blennow
authors.forename: Pernille J
authors.initials: PJ
authors.lastname: Olesen
authors.forename: Henrik
authors.initials: H
authors.lastname: Zetterberg
authors.forename: Anders
authors.initials: A
authors.lastname: Wallin
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000134:cerebrospinal fluid; D003072:Cognition Disorders / Q000134:cerebrospinal fluid* / Q000523:psychology*; D004522:Educational Status; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010446:Peptide Fragments / Q000134:cerebrospinal fluid; D011569:Psychiatric Status Rating Scales; D018709:Statistics, Nonparametric; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); D016875:tau Proteins