Factors associated with Marburg hemorrhagic fever: analysis of patient data from Uige, Angola.
BACKGROUND
Reliable on-site polymerase chain reaction (PCR) testing for Marburg hemorrhagic fever (MHF) is not always available. Therefore, clinicians triage patients on the basis of presenting symptoms and contact history. Using patient data collected in Uige, Angola, in 2005, we assessed the sensitivity and specificity of these factors to evaluate the validity of World Health Organization (WHO)-recommended case definitions for MHF.


METHODS
Multivariable logistic regression was used to identify independent predictors of PCR confirmation of MHF. A data-derived algorithm was developed to obtain new MHF case definitions with improved sensitivity and specificity.


RESULTS
A MHF case definition comprising (1) an epidemiological link or (2) the combination of myalgia or arthralgia and any hemorrhage could potentially serve as an alternative to current case definitions. Our data-derived case definitions maintained the sensitivity and improved the specificity of current WHO-recommended case definitions.


CONCLUSIONS
Continued efforts to improve clinical documentation during filovirus outbreaks would aid in the refinement of case definitions and facilitate outbreak control.
Roddy
Paul
P
Médecins Sans Frontières-Spain, Barcelona, Spain.
Thomas
Sara L
SL
Jeffs
Benjamin
B
Nascimento Folo
Pascoal
P
Pablo Palma
Pedro
P
Moco Henrique
Bengi
B
Villa
Luis
L
Damiao Machado
Fernando Paixao
FP
Bernal
Oscar
O
Jones
Steven M
SM
Strong
James E
JE
Feldmann
Heinz
H
Borchert
Matthias
M
D000293:Adolescent; D000328:Adult; D000810:Angola; D000818:Animals; D002648:Child; D002675:Child, Preschool; D016358:Contact Tracing; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008379:Marburg Virus Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology* / Q000821:virology; D029024:Marburgvirus / Q000235:genetics / Q000302:isolation & purification; D008875:Middle Aged; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012680:Sensitivity and Specificity; D055815:Young Adult