[Effect of verapamil on production of anti-inflammatory cytokines by peritoneal mononuclears].
Effects ofverapamil, a slow calcium channel blocker, on the production of anti-inflammatory cytokines (TNF-alpha and IL-beta) by peritoneal mononuclears were studied using a rat model of aseptic intra-abdominal inflammation. Autohemoperitoneum was simulated by intraperitoneal administration of autoblood (group 1). The similarly treated animals of group 2 were additionally given verapamil. A statistically significant rise in the TNF-alpha and IL-beta levels was documented in the former case. In group 2, verapamil substantially modified functional activity of peritoneal macrophages in that TNF-alpha content in peritoneal exudate was twice lower than in group 1 while the IL-beta level remained unaltered. These findings suggest that slow calcium channels are involved in regulation of cytokine-producing function of mononuclear cells during intra-abdominal inflammation.
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D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D002921:Cicatrix / Q000473:pathology / Q000517:prevention & control; D016207:Cytokines / Q000096:biosynthesis*; D006465:Hemoperitoneum / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010538:Peritonitis / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D016207:Cytokines; D014700:Verapamil