Chiral resolution of a racemic macrocyclic complex by recognition of one enantiomer over the other: structures and DFT calculations.
The enantiopure agents d- and l-leucine, selectively bind RR and SS enantiomers from a racemate [Ni(alpha-rac-L)](2+) to give {[Ni(RR-L)(d-HLeu)](ClO(4))(2)}(n) (Delta-) and {[Ni(SS-L)(l-HLeu)](ClO(4))(2)}(n) (Lambda-), respectively, and leave the corresponding uninteracted SS and RR enantiomers of [Ni(alpha-SS-L)](ClO(4))(2) (S-) and [Ni(alpha-RR-L)](ClO(4))(2) (R-). Occasionally, a few crystals of {[Ni(RR-L)(l-HLeu)](ClO(4))(2)}(n) (Delta-) and {[Ni(SS-L)(d-HLeu)](ClO(4))(2)}(n) (Lambda-) were found to have accreted with the crystals of Lambda-/R-, and Delta-/S-, respectively (the yields are less than 2%). The results of X-ray crystal structural analysis reveal that Delta- and Lambda-, S- and R-, and Delta- and Lambda- are enantiomers, in which Delta- and Delta- possess 1D right-handed helical chains, while Lambda- and Lambda- exhibit a motif of 1D left-handed helical chains. The results of DFT calculations reveal that the single-point energies of [Ni(RR-L)(d-HLeu)](2+)/[Ni(SS-L)(l-HLeu)](2+) in Delta-/Lambda- are 582 kJ mol(-1) lower than those of [Ni(RR-L)(l-HLeu)](2+)/[Ni(SS-L)(d-HLeu)](2+) in Delta-/Lambda-, demonstrating the favorable stereo-coordination environments of [Ni(alpha-RR-L)](2+) and [Ni(alpha-SS-L)](2+) towards d and l-HLeu, respectively.
Ou
Guang-Chuan
GC
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry/State Key Laboratory of Optoelectronic Materials and Technologies/School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou, 510275, China.
Wang
Zi-Zhou
ZZ
Yang
Li-Zi
LZ
Zhao
Cun-Yuan
CY
Lu
Tong-Bu
TB
D002942:Circular Dichroism; D056831:Coordination Complexes / Q000737:chemistry; D018360:Crystallography, X-Ray; D008024:Ligands; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008968:Molecular Conformation; D009532:Nickel / Q000737:chemistry; D013237:Stereoisomerism
D056831:Coordination Complexes; D008024:Ligands; D047028:Macrocyclic Compounds; D009532:Nickel