Noninvasive markers to diagnose cirrhosis in patients with HBeAg positive chronic hepatitis: Do new biomarkers improve the accuracy?
OBJECTIVE
The goal of the study was to clarify whether new biomarkers independently contribute to the diagnosis of cirrhosis.


METHODS
A total of 142 consecutive patients with HBeAg positive chronic hepatitis who underwent liver biopsy were recruited. The Cirrhosis Score (CS)-1 was derived from routine laboratory data only. The CS-2 was calculated using all correlates obtained from both routine laboratory data and 7 new biomarkers.


RESULTS
A comparison of the area under the receiver operating characteristic (ROC) curve between CS-1 [0.84 (95% CI, 0.74 to 0.94)] and CS-2 [0.86 (0.78 to 0.95)] showed no superior diagnostic accuracy of CS-2 over CS-1 (p=0.24).


CONCLUSIONS
None of the new biomarkers had value in addition to readily available laboratory data for differentiating cirrhosis from HBeAg positive chronic hepatitis B.
Park
Seung Ha
SH
Department of Internal Medicine, Inje University Haeundae Paik-Hospital, Busan, Republic of Korea.
Kim
Dong Joon
DJ
Cheong
Jae Youn
JY
Cho
Sung Won
SW
Hwang
Seong Gyu
SG
Lee
Youn Jae
YJ
Cho
Mong
M
Yang
Jin Mo
JM
Kim
Young Bae
YB
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D044963:Biopsy, Fine-Needle; D018450:Disease Progression; D005260:Female; D006513:Hepatitis B e Antigens / Q000097:blood*; D019694:Hepatitis B, Chronic / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000145:classification / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D055815:Young Adult
D015415:Biomarkers; D006513:Hepatitis B e Antigens