title: [Effect of malondialdehyde on deformability of human umbilical vein endothelial cells].
abstract: In experiments on cultured endothelial cells of human umbilical vein, we found that incubation of these cells during 24 hours with malondiaidehyde (cone. 200 microM) led to over two-fold increase in the cell stiffness. These data suggest that manifold augmentation of malondialdehyde concentration during oxidative stress may be accompanied by a considerable weakening of endothelium-dependent shear stress-induced arterial dilation.
authors.forename: I D
authors.initials: ID
authors.lastname: Kakorin
authors.forename: O A
authors.initials: OA
authors.lastname: Antonova
authors.forename: S A
authors.initials: SA
authors.lastname: Balashov
authors.forename: A M
authors.initials: AM
authors.lastname: Mel'kumiants
mesh_terms: D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D008315:Malondialdehyde / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D014471:Umbilical Veins / Q000166:cytology / Q000378:metabolism*
chemical_list: D008315:Malondialdehyde