title: Tandem Michael addition/intramolecular isocyanide [3 + 2] cycloaddition: highly diastereoselective one pot synthesis of fused oxazolines.
abstract: A base-catalyzed tandem Michael addition/intramolecular isocyanide [3 + 2] cycloaddition of ethyl isocyanoacetate and Michael acceptors with tethered carbonyl groups is described. This reaction leads to the formation of fused oxazolines in a highly diastereoselective manner under very mild conditions.
authors.affiliation: Department of Chemistry, Northeast Normal University, Changchun 130024, China.
authors.forename: Lingjuan
authors.initials: L
authors.lastname: Zhang
authors.forename: Xianxiu
authors.initials: X
authors.lastname: Xu
authors.forename: Jing
authors.initials: J
authors.lastname: Tan
authors.forename: Ling
authors.initials: L
authors.lastname: Pan
authors.forename: Wenming
authors.initials: W
authors.lastname: Xia
authors.forename: Qun
authors.initials: Q
authors.lastname: Liu
mesh_terms: D003486:Cyanides / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D003486:Cyanides; D010080:Oxazoles