title: Azathioprine-induced liver injury in a patient with multiple autoimmune syndrome.
abstract: Extraintestinal manifestations are frequent in patients with ulcerative colitis. They are most commonly associated with active bowel disease but can also occur prior to bowel disease or during a period of remission. The disease often requires long-term therapy. The tolerability of drugs is essential for the comprehensive management of patients. Azathioprine is considered an indispensable drug for the treatment of severe ulcerative colitis patients. It is used to prevent relapse or to treat patients who are refractory to corticosteroids. We report a patient who had alopecia areata, vitiligo, recurrent episcleritis, ulcerative colitis and azathioprine-induced liver injury, and review the related literature.
authors.affiliation: Department of Dermatology, Medical Park Bahcelievler Hospital, Istanbul, Turkey. gokhanokan8@hotmail.com
authors.forename: Gokhan
authors.initials: G
authors.lastname: Okan
authors.forename: Pervin
authors.initials: P
authors.lastname: Vural
authors.forename: Onder
authors.initials: O
authors.lastname: Peker
authors.forename: Emel
authors.initials: E
authors.lastname: Colakoglu
authors.forename: Murat
authors.initials: M
authors.lastname: Saruc
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases; D001379:Azathioprine / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D013577:Syndrome
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D001379:Azathioprine; D011241:Prednisone