Identification of a novel HLA-A allele, HLA-A*0355, in a Brazilian family of eastern European descendents.
The new human leukocyte antigen (HLA) class I allele, HLA-A*0355 was identified in a Brazilian family. Our sequence analysis detected a mismatch located in exon 2, codon 86, at position 258 (C-->A) that results in a nonsilent and nonconservative substitution with the replacement of asparagine by lysine. Substitutions located at this oligosaccharide attachment site of the protein were observed in only other four classic HLA class I sequences, indicating a highly conserved peptide site however its function remains unknown.
Mattar
Sibelle Botogosque
SB
Laboratory of Immunogenetics and Histocompatibility, Genetics Department, Universidade Federal do Paraná, Curitiba, Brazil.
Uehara
Clineu Julien Seki
CJ
Ribas
Fernanda
F
Poerner
Fabiana
F
de Rezende
Gorete Ynaquievi Tomaz
GY
Vargas
Rafael Gustavo
RG
Wowk
Pryscilla Fanini
PF
da Graça Bicalho
Maria
M
D000328:Adult; D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics; D001483:Base Sequence / Q000235:genetics; D001938:Brazil; D003001:Cloning, Molecular; D005061:Europe, Eastern / Q000208:ethnology; D005260:Female; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics*; D015789:HLA-A2 Antigen; D015791:HLA-A3 Antigen; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D035781:Siblings; D044465:White People / Q000235:genetics*
D015234:HLA-A Antigens; C435939:HLA-A*02:01 antigen; C442141:HLA-A*03:01 antigen; D015789:HLA-A2 Antigen; D015791:HLA-A3 Antigen