title: Molecular structure of sarcomere-to-membrane attachment at M-Lines in C. elegans muscle.
abstract: C. elegans is an excellent model for studying nonmuscle cell focal adhesions and the analogous muscle cell attachment structures. In the major striated muscle of this nematode, all of the M-lines and the Z-disk analogs (dense bodies) are attached to the muscle cell membrane and underlying extracellular matrix. Accumulating at these sites are many proteins associated with integrin. We have found that nematode M-lines contain a set of protein complexes that link integrin-associated proteins to myosin thick filaments. We have also obtained evidence for intriguing additional functions for these muscle cell attachment proteins.
authors.affiliation: Department of Pathology, Emory University, Atlanta, GA 30322, USA.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Qadota
authors.forename: Guy M
authors.initials: GM
authors.lastname: Benian
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000737:chemistry / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D022001:Focal Adhesions / Q000502:physiology; D016023:Integrins / Q000502:physiology; D009124:Muscle Proteins / Q000502:physiology; D009132:Muscles / Q000737:chemistry / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D012518:Sarcomeres / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure
chemical_list: D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D016023:Integrins; D009124:Muscle Proteins