Label-free SERS detection of microRNA based on affinity for an unmodified silver nanorod array substrate.
A silver nanorod array has been used for the intrinsic SERS detection of microRNAs based on different binding affinities of ssRNA, thiolated ssDNA, and the RNA:DNA duplex, eliminating the need for a labelling step.
Driskell
Jeremy D
JD
University of Georgia, Nanoscale Science and Engineering Center and Department of Infectious Diseases, 111 Carlton St.-AHRC Athens, GA 30602, USA. jdriskel@uga.edu
Tripp
Ralph A
RA
D001667:Binding, Competitive; D004247:DNA / Q000737:chemistry; D035683:MicroRNAs / Q000032:analysis*; D036103:Nanotechnology; D043942:Nanotubes / Q000737:chemistry*; D012313:RNA / Q000737:chemistry; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman; D013499:Surface Properties
D035683:MicroRNAs; D012834:Silver; D012313:RNA; D004247:DNA