title: Asymmetric dimethylarginine--a determinant of the effect of the high dose Simvastatin.
abstract: OBJECTIVE
  Research of statins influence on flow induced vasodilatation reveals controversial results.
  
  
  METHODS
  We analyze whether asymmetric dimethylarginine (ADMA) levels influence the effect of 80mg/day simvastatin on flow-mediated vasodilation (%FMD). A total of 200 hypercholesterolemic patients were enrolled. Biochemistry parameters were examined by routine methods. Determination of %FMD was performed with software MedicaSoft. Patients were assigned into two groups according to the ADMA level.
  
  
  RESULTS
  Simvastatin, 80mg/day for 1month, resulted in changes in routine lipid profile and apolipoproteins, but there was not reduction of ADMA and homocysteine. In the group with ADMA<1.03micromol/L a significant increase of %FMD was observed, whereas no such was found in the group with ADMA>or=1.03micromol/L. %FMD-change correlated significant with baseline level of Apo-capital VE, Cyrillic and capital A, CyrillicDMA.
  
  
  CONCLUSIONS
  Asymmetric dimethylarginine level was found to determine the effect of high-dose simvastatin on %FMD.
authors.affiliation: Clinic of Cardiology, University of Medicine, 2 Alexander Eksarch Str., 4000 Plovdiv, Bulgaria. kitov@vip.bg
authors.forename: Lyudmila G
authors.initials: LG
authors.lastname: Vladimirova-Kitova
authors.forename: Tania
authors.initials: T
authors.lastname: Deneva-Koycheva
mesh_terms: D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D019821:Simvastatin / Q000008:administration & dosage*; D014664:Vasodilation / Q000187:drug effects*
chemical_list: C487735:dimethylarginine; D001120:Arginine; D019821:Simvastatin