title: A patient with persistent pruritus.
abstract: We present a patient with an initial and acute presentation of jaundice and marked persistent pruritus. Laboratory and radiology test results eliminated the possibility of acute hepatitis A/B/C viral infections, primary biliary cirrhosis, autoimmune hepatitis, Wilson disease, paraneoplastic cholestasis, and obstructive biliary disease. Centrilobular cholestasis was prominent in a liver biopsy specimen. Benign recurrent intrahepatic cholestasis (BRIC) was diagnosed through a review of the clinical history, available data, and the subsequent exclusion of other possible etiologies. The patient's clinical features resolved within 3 months of medical treatment.
authors.affiliation: Division of Liver Diseases, The Mount Sinai Medical Center, New York, New York 10029, USA. Lawrence.Liu@mountsinai.org
authors.forename: Lawrence U
authors.initials: LU
authors.lastname: Liu
authors.forename: Lihui
authors.initials: L
authors.lastname: Qin
authors.forename: A S
authors.initials: AS
authors.lastname: Knisely
mesh_terms: D002780:Cholestasis, Intrahepatic / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000473:pathology; D015260:Neprilysin / Q000378:metabolism; D011168:Portal System / Q000473:pathology; D011537:Pruritus / Q000209:etiology* / Q000473:pathology; D012008:Recurrence; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000378:metabolism
chemical_list: D005723:gamma-Glutamyltransferase; D015260:Neprilysin