Effect of metformin on miscarriage in pregnant patients with polycystic ovary syndrome.
BACKGROUND
This study was performed with the aim of evaluating the effect of metformin in reducing miscarriage when continued until the end of the first trimester of pregnancy in patients with polycystic ovary syndrome (PCOS) and infertility.


METHODS
From January 2004 to December 2005, a total of 75 pregnant women with PCOS were studied in three different groups. In Group A, metformin administration (500 mg three times daily (TDS)) was stopped immediately after diagnosis of pregnancy (5-6 weeks gestation), in Group B, metformin was administered until the end of 8 weeks gestation and in Group C until the end of 12 weeks gestation. The results of this study were then assessed using chi-square McNemar's, ANOVA Kruskal Wallis and logistic regression tests.


RESULTS
There was a significant statistical difference between previous and current miscarriage in the current pregnancy with a decline in Group B from 40% to 8% and in group C from 32% to 4%. In spite of the reduced rate of miscarriage seen in Group A, from 20% to 4%, this difference was not statistically significant. Fetal anomalies were absent in all three groups.


CONCLUSIONS
According to the current findings, it seems that continuing metformin during the first trimester of pregnancy has beneficial effects in patients with PCOS.
Sohrabvand
F
F
Tehran University of Medical Sciences, Vali-e-Asr Reproductive Health Research Center, Iman Khomeini Hospital Complex, Tehran University of Medical Sciences, Keshavarz Boulevard, Tehran 14194 Iran. fsohrabvand@yahoo.com
Shariat
M
M
Haghollahi
F
F
Bagheri
B
B
D000022:Abortion, Spontaneous / Q000517:prevention & control*; D000328:Adult; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D008687:Metformin / Q000008:administration & dosage*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D055815:Young Adult
D007004:Hypoglycemic Agents; D008687:Metformin