[Activity of free radical oxidation and antioxidative system in peripheral blood lymphocytes of patients with autoimmune thyroiditis].
The aim of this work was to evaluate selected parameters of oxidative metabolism in peripheral blood lymphocytes of patients with autoimmune thyroiditis (AIT) at the stages of eu- and hypothyroidism. The lymphocytes were shown to accumulate superoxide anion radical, hydrogen peroxide, and TBA-active products in association with the decrease of major enzymatic activities (superoxide dismutase and catalase). Changes in free radical oxidation and activity of key antioxidative enzymes in AIT patients proved unidirectional.
Rogaleva
A V
AV
Urazova
O I
OI
Kravets
E B
EB
Novitskiĭ
V V
VV
Sukhaentseva
N A
NA
Ivanova
O I
OI
Engel'
E E
EE
D000328:Adult; D000368:Aged; D002374:Catalase / Q000097:blood*; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D007962:Leukocytes / Q000378:metabolism*; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D009573:Nitrites / Q000097:blood; D010084:Oxidation-Reduction; D017382:Reactive Oxygen Species / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood*; D013481:Superoxides / Q000097:blood; D013967:Thyroiditis, Autoimmune / Q000097:blood*
D009573:Nitrites; D017382:Reactive Oxygen Species; D013481:Superoxides; D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase