The apoptosome at high resolution.
The mechanism by which the apoptosome activates caspases during apoptosis has been controversial. Qi et al. (2010) now present a crystal structure of a funnel-shaped octameric apoptosome complex from the nematode Caenorhabditis elegans that challenges currently held assumptions about the human apoptosome structure.
Teng
Xinchen
X
Department of Pharmacology and Molecular Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
Hardwick
J Marie
JM