title: Relation of resistin levels with cardiovascular risk factors, insulin resistance and inflammation in naïve diabetes obese patients.
abstract: BACKGROUND
  The aim of the present study was to explore the relationship of resistin levels with cardiovascular risk factors, insulin resistance and inflammation in naïve diabetic patients.
  
  
  METHODS
  A population of 66 naïve diabetic patients with obesity was analyzed. A complete nutritional and biochemical evaluation was performed.
  
  
  RESULTS
  The mean age 56.9+/-11.6 years and the mean BMI was 37.8+/-6.3. Patients were divided in two groups by median resistin value (3.3ng/ml), group I (patients with the low values, average value 2.5+/-0.5) and group II (patients with the high values, average value 4.8+/-1.8). Patients in the group I had lower waist circumference, total cholesterol, LDL-cholesterol and C-reactive protein than patients in group II. Correlation analysis showed a significant correlation among resistin levels and the independent variables; BMI (r=0.26; p<0.05), waist circumference (r=0.38; p<0.05), fat mass (r=0.28; p<0.05), LDL-cholesterol (r=0.3; p<0.05), C-reactive protein (r=0.28; p<0.05). In the multivariate analysis, resistin concentration increase 0.024ng/ml (CI 95%: 0.006-0.42) for each mg/dl of C-reactive protein.
  
  
  CONCLUSIONS
  Circulating resistins are associated with C-reactive protein in an independent way in naïve diabetic patients.
authors.affiliation: Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, RD-056/0013 RETICEF, University of Valladolid, C/Los Perales 16, Simancas 47130, Valladolid, Spain. Dadluis@yahoo.es
authors.forename: D A
authors.initials: DA
authors.lastname: de Luis
authors.forename: M Gonzalez
authors.initials: MG
authors.lastname: Sagrado
authors.forename: R
authors.initials: R
authors.lastname: Conde
authors.forename: R
authors.initials: R
authors.lastname: Aller
authors.forename: O
authors.initials: O
authors.lastname: Izaola
authors.forename: B
authors.initials: B
authors.lastname: de la Fuente
authors.forename: J L Perez
authors.initials: JL
authors.lastname: Castrillón
authors.forename: E
authors.initials: E
authors.lastname: Romero
mesh_terms: D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood*; D052243:Resistin / Q000097:blood*; D012307:Risk Factors
chemical_list: D052243:Resistin