Electrochemical behavior of indole-3-carboxaldehyde izonicotinoyl hydrazones: discussion on possible biological behavior.
Electrochemical techniques provide valuable information about drug molecules and their mechanisms in the body such as metabolism is getting one of the important actions in drug discovery. Since many physiological processes are depending on oxido-reduction reactions, it is not difficult to find associations between electrochemical and biological reactions regarding electron transfers. To investigate this proposal two compounds namely 1-methylindole-3-carboxaldehyde izonicotinoyl hydrazone and 5-chloro-1H-indole-3-carboxaldehyde izonicotinoyl hydrazone were synthesized, characterized and examined electrochemically using different voltammetric techniques in order to evaluate the possible biological behavior. The characteristics of the corresponding electrode reaction were discussed. A linear response was obtained in the different media for the compounds with low detection limits of the synthesized compounds.
Shirinzadeha
Hanif
H
Department of Pharmaceutical Chemistry, Ankara Univetsity, Tandogan, Turkey.
Yilmaza
Ayse Didem
AD
Gumustasb
Mehmet
M
Suzena
Sibel
S
Ozdena
Seckin
S
Ozkan
Sibel A
SA
D002244:Carbon / Q000737:chemistry; D004563:Electrochemistry; D004566:Electrodes; D057166:High-Throughput Screening Assays / Q000379:methods*; D006835:Hydrazones / Q000138:chemical synthesis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010084:Oxidation-Reduction
C555467:1-methylindole-3-carboxaldehyde izonicotinoyl hydrazone; C555468:5-chloro-1H-indole-3-carboxaldehyde izonicotinoyl hydrazone; D006835:Hydrazones; D007211:Indoles; D002244:Carbon