Prognostic role of serum cancer antigen 15-3 in breast cancer patients with isolated bone metastases.
OBJECTIVE
To investigate the association between cancer antigen (CA) 15-3 and clinicopathological parameters in patients who had breast cancer with isolated bone metastases at the time of diagnosis and to analyse the effect on clinical outcomes.


METHODS
Between June 2004 and January 2007, the data of 129 consecutive patients were examined.


RESULTS
Elevated CA 15-3 levels were associated with poor disease-free survival (p = 0.001) and overall survival (p = 0.006). In multivariate analysis, serum CA 15-3 level (p = 0.003) was found to be an independent factor in overall survival.


CONCLUSIONS
Elevated CA 15-3 level is a useful parameter for predicting clinical outcomes.
Turanli
Sevim
S
Department of General Surgery, Ankara Oncology Education and Research Hospital, Demetevler, Ankara, Turkey. turanlisevim@hotmail.com
Cetin
Abdullah
A
D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D001859:Bone Neoplasms / Q000097:blood / Q000556:secondary*; D001943:Breast Neoplasms / Q000097:blood / Q000473:pathology*; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood*; D015999:Multivariate Analysis; D011379:Prognosis; D012307:Risk Factors
D014408:Biomarkers, Tumor; D018396:Mucin-1