title: Nonsteroidal anti-inflammatory drugs in orthopaedics.
abstract: It is important for orthopaedic surgeons to understand the role of prostaglandins in bone physiology and the mechanism of action of nonsteroidal anti-inflammatory drugs and their role in fracture healing, fusion, osteointegration, and aseptic loosening. Nonsteroidal anti-inflammatory drugs have benefits and risks in orthopaedic use, and their effects should be considered.
authors.affiliation: Southern Oregon Orthopedics, Medford, Oregon, USA.
authors.forename: Omar
authors.initials: O
authors.lastname: Abdul-Hadi
authors.forename: Javad
authors.initials: J
authors.lastname: Parvizi
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Austin
authors.forename: Eugene R
authors.initials: ER
authors.lastname: Viscusi
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Einhorn
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001842:Bone and Bones / Q000187:drug effects*; D005592:Fracture Fixation; D017102:Fracture Healing / Q000187:drug effects*; D006801:Humans; D016348:Osseointegration / Q000187:drug effects*; D011475:Prosthesis Failure; D013123:Spinal Fusion; D013710:Tendons / Q000187:drug effects*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal