Sesquiterpene lactones from Inula oculus-christi.
Inula oculus-christi L. (Compositae) extract was chromatographed and three sesquiterpene lactones ergolide, gaillardin and pulchellin C were isolated. The structures of these compounds were determined by analysis of their spectroscopic data, and their crystal structures were defined using X-ray crystallography; the isolation of ergolide and pulchellin C is reported for the first time from this species. These three compounds were evaluated for their in vitro cytotoxic activity against MDBK, MCF7 and WEHI164 cells; ergolide and gaillardin exhibited lower and significantly different IC50 values compared with pulchellin C (p<0.001).
Mosaddegh
Mahmoud
M
Traditional Medicine and Materia Medica Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. mmosaddegh@itmrc.org
Moghadam
Maryam Hamzeloo
MH
Ghafari
Saeedeh
S
Naghibi
Farzaneh
F
Ostad
Seyed Nasser
SN
Read
Roger W
RW
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002417:Cattle; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D018360:Crystallography, X-Ray; D005562:Formazans / Q000737:chemistry; D006801:Humans; D038143:Inula / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013058:Mass Spectrometry; D019906:Nuclear Magnetic Resonance, Biomolecular; D035261:Plant Components, Aerial / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013778:Tetrazolium Salts / Q000737:chemistry
D000970:Antineoplastic Agents; D005562:Formazans; D007783:Lactones; D012717:Sesquiterpenes; D013778:Tetrazolium Salts; C079782:MTT formazan