title: Multi-residue determination of pesticides in fruit-based soft drinks by fast liquid chromatography time-of-flight mass spectrometry.
abstract: This work reports a rapid and reliable method for the determination of 33 multi-class pesticides in fruit-based soft drinks. The proposed method consists of a sample treatment step based on solid-phase extraction using hydrophilic-lipophilic balanced polymer-based reverse-phase SPE cartridges, followed by identification and quantitation of the target pesticides by rapid resolution liquid chromatography using a short C(18) column (4.6mm x 50mm) with 1.8microm particle size and mass spectrometric detection using electrospray time-of-flight mass spectrometry (LC-TOFMS). The identification and confirmation of the compounds were based on retention time matching along with the accurate mass measurements of the protonated molecules ([M+H](+)) and their main fragment ions. Fruit-based soft drinks spiked at different fortification levels (10 and 50microgL(-1)) yielded average recoveries in the range 66-124% with RSD (%) below 14% (n=6). The obtained limits of quantitation varied in the range 0.02-2microgL(-1). The proposed method was successfully applied to the analysis of 14 market-purchased fruit-based soft drinks samples collected in some European countries, showing its potential applicability and revealing the presence of some of the target species in the microgL(-1) range.
authors.affiliation: Analytical Chemistry Research Group, Department of Physical and Analytical Chemistry, University of Jaén, Jaén, Spain.
authors.forename: Bienvenida
authors.initials: B
authors.lastname: Gilbert-López
authors.forename: Juan F
authors.initials: JF
authors.lastname: García-Reyes
authors.forename: Milagros
authors.initials: M
authors.lastname: Mezcua
authors.forename: Natividad
authors.initials: N
authors.lastname: Ramos-Martos
authors.forename: Amadeo R
authors.initials: AR
authors.lastname: Fernández-Alba
authors.forename: Antonio
authors.initials: A
authors.lastname: Molina-Díaz
mesh_terms: D002253:Carbonated Beverages / Q000032:analysis*; D002623:Chemistry Techniques, Analytical; D002853:Chromatography, Liquid / Q000379:methods*; D005504:Food Analysis / Q000379:methods*; D005506:Food Contamination; D005638:Fruit; D007477:Ions; D013058:Mass Spectrometry / Q000379:methods*; D010573:Pesticide Residues / Q000032:analysis*; D010575:Pesticides / Q000032:analysis*; D011522:Protons; D012997:Solvents / Q000737:chemistry
chemical_list: D007477:Ions; D010573:Pesticide Residues; D010575:Pesticides; D011522:Protons; D012997:Solvents