title: Cytotoxic prenylated isoflavone and bipterocarpan from Millettia pachyloba.
abstract: Two new compounds, an isoflavone (1, 6-methoxybarbigerone) and a bipterocarpan (2, pachylobin) were isolated from the grains of Millettia pachyloba (Leguminosae), together with seven known compounds, 5-methoxybarbigerone (3), calopogoniumisoflavone B (4), durmillone (5), jamaicin (6), ichthynone (7), (-)-pisatin (8) and (-)-rotenone (9). The structures were established from spectroscopic analyses, including mass spectrometry and 2D-NMR. Absolute configuration of 2 was proposed based on that of the known compound (-)-pisatine (8). Compounds 1 and 2 exhibited cytotoxicity against KB cells with IC(50) values of 2.0 and 17.6 µM, respectively.
authors.affiliation: Institute of Chemistry-VAST, Hanoi, Vietnam. dtmhuong@ich.vast.ac.vn
authors.forename: Huong Doan Thi
authors.initials: HD
authors.lastname: Mai
authors.forename: Thi Tu Oanh
authors.initials: TT
authors.lastname: Nguyen
authors.forename: Van Cuong
authors.initials: VC
authors.lastname: Pham
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
authors.forename: Françoise
authors.initials: F
authors.lastname: Guéritte
authors.forename: Dinh Toai
authors.initials: DT
authors.lastname: Tran
authors.forename: Van Hung
authors.initials: VH
authors.lastname: Nguyen
mesh_terms: D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007624:KB Cells; D033641:Millettia / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D054876:Prenylation; D036343:Pterocarpans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C557365:1,6-methoxybarbigerone; D003603:Cytotoxins; D007529:Isoflavones; D036343:Pterocarpans; C557364:pachylobin