[Epigenetic mechanism of RUNX1 in pathogenesis of leukemia].
RUNX1, also called AML1, is a member of RUNX transcriptional factor family, and also is the most frequent target for chromosomal translocations in leukemia. RUNX1 is a very important transcription factor, can enhance or repress the expressions of many hematopoiesis related genes. RUNX1 may receive a series of post-translational modifications, and the activity of RUNX1 can be affected by these post-translational modifications, thus RUNX1 regulates the differentiation, apoptosis and self-renewal of hematopoietic cells. This article reviews the role of RUNX1 in the pathogenesis of leukemia mainly including its target genes, transcriptional mechanism and post-translational modifications.
Zhang
Han
H
Hematological Center, Beijing Children Hospital, Capital Medical University, Beijing 100045, China.
Zheng
Hu-Yong
HY
D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics*; D044127:Epigenesis, Genetic; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000378:metabolism; D011499:Protein Processing, Post-Translational
D050676:Core Binding Factor Alpha 2 Subunit