title: Induction of indoleamine 2,3-dioxygenase expression via heme oxygenase-1-dependant pathway during murine dendritic cell maturation.
abstract: Heme oxygenase (HO)-1 is expressed in a variety of conditions involved in the regulation of immune responses. In this study, we examined the role of HO-1 in dendritic cell (DC) maturation and expression of indoleamine 2,3-dioxygenase (IDO), a key enzyme that catalyzes the initial, rate-limiting step in tryptophan degradation. IDO deficiency led to diminished phenotypic and functional maturation of DCs in vitro and in vivo. IDO expression and DC maturation was abrogated by the HO inhibitor zinc protoporphrin, but increased by hemin, a potent inducer of HO-1. Moreover, LPS-induced HO-1 expression was mediated by an NF-kappaB-dependent pathway. Our findings provide additional insight into the immunological functions of IDO and HO-1, and suggest possible therapeutic adjuvants for the treatment of DC-related acute and chronic diseases.
authors.affiliation: Department of Microbiology, Pusan National University, Beom-eo Ri, Mulgum Eop, Yangsan, Gyeongsangnam-do, South Korea.
authors.forename: In Duk
authors.initials: ID
authors.lastname: Jung
authors.forename: Jun Sik
authors.initials: JS
authors.lastname: Lee
authors.forename: Chang-Min
authors.initials: CM
authors.lastname: Lee
authors.forename: Kyung Tae
authors.initials: KT
authors.lastname: Noh
authors.forename: Yeong-Il
authors.initials: YI
authors.lastname: Jeong
authors.forename: Won Sun
authors.initials: WS
authors.lastname: Park
authors.forename: Sung Hak
authors.initials: SH
authors.lastname: Chun
authors.forename: Soo Kyung
authors.initials: SK
authors.lastname: Jeong
authors.forename: Jin Wook
authors.initials: JW
authors.lastname: Park
authors.forename: Kwang Hee
authors.initials: KH
authors.lastname: Son
authors.forename: Deok Rim
authors.initials: DR
authors.lastname: Heo
authors.forename: Min-Goo
authors.initials: MG
authors.lastname: Lee
authors.forename: Yong Kyoo
authors.initials: YK
authors.lastname: Shin
authors.forename: Han Wool
authors.initials: HW
authors.lastname: Kim
authors.forename: Cheol-Heui
authors.initials: CH
authors.lastname: Yun
authors.forename: Yeong-Min
authors.initials: YM
authors.lastname: Park
mesh_terms: D000818:Animals; D048708:Cell Growth Processes; D002478:Cells, Cultured; D016922:Cellular Senescence / Q000502:physiology*; D003713:Dendritic Cells / Q000502:physiology*; D004790:Enzyme Induction; D051547:Heme Oxygenase-1 / Q000502:physiology*; D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase / Q000378:metabolism* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D050503:Indoleamine-Pyrrole 2,3,-Dioxygenase; D051547:Heme Oxygenase-1