title: Topical piperacillin/tazobactam for recalcitrant pseudomonas aeruginosa keratitis.
abstract: OBJECTIVE
  To report the treatment of therapy-resistant Pseudomonas aeruginosa keratitis with topical piperacillin/tazobactam.
  
  
  METHODS
  Retrospective report of 3 cases.
  
  
  RESULTS
  Three patients with P. aeruginosa keratitis were unresponsive to various antimicrobials. Resolution of all 3 cases of keratitis occurred upon commencement of topical piperacillin/tazobactam.
  
  
  CONCLUSIONS
  Therapy-resistant P. aeruginosa keratitis acquired from the community is becoming an increasing problem. Topical piperacillin/tazobactam is an option for the treatment of therapy-resistant P. aeruginosa keratitis.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, Wilayah Persekutuan 50603, Malaysia. sabrefmin@yahoo.co.uk
authors.forename: Fiona L M
authors.initials: FL
authors.lastname: Chew
authors.forename: T K
authors.initials: TK
authors.lastname: Soong
authors.forename: Hoy Choong
authors.initials: HC
authors.lastname: Shin
authors.forename: A
authors.initials: A
authors.lastname: Samsudin
authors.forename: Subrayan
authors.initials: S
authors.lastname: Visvaraja
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000503:physiopathology; D004351:Drug Resistance; D015818:Eye Infections, Bacterial / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives; D010878:Piperacillin / Q000008:administration & dosage; D000077725:Piperacillin, Tazobactam Drug Combination; D011379:Prognosis; D011552:Pseudomonas Infections / Q000188:drug therapy* / Q000503:physiopathology; D012189:Retrospective Studies
chemical_list: D000900:Anti-Bacterial Agents; D009883:Ophthalmic Solutions; D000077725:Piperacillin, Tazobactam Drug Combination; D010397:Penicillanic Acid; D010878:Piperacillin