title: Sustainable synthesis of flavonoid derivatives, QSAR study and insecticidal activity against the fall armyworm, Spodoptera frugiperda (Lep.: Noctuidae).
abstract: A simple, clean, solvent-free preparation of flavones by the use of a silica-supported Preyssler heteropolyacid as reusable catalyst is described. High selectivity and very good yields (87-94%) were obtained in short reaction times (7-13 min). Bioassays for insecticidal activity against Spodoptera frugiperda were carried out with a set of flavones. Bioassays showed that some of the flavones had moderate insecticidal activity. Quantitative structure-activity relationships were established on the available data with the purpose of predicting the insecticidal activity of a number of structurally related flavones. A relationship between the molecular structure and biological activity is proposed.
authors.affiliation: Cátedra de Química Orgánica, Facultad de Ciencias Agrarias y Forestales, Universidad Nacional de La Plata, Calles 60 y 119, 1904 La Plata, Argentina.
authors.forename: Gustavo P
authors.initials: GP
authors.lastname: Romanelli
authors.forename: Eduardo G
authors.initials: EG
authors.lastname: Virla
authors.forename: Pablo R
authors.initials: PR
authors.lastname: Duchowicz
authors.forename: Ana L
authors.initials: AL
authors.lastname: Gaddi
authors.forename: Diego M
authors.initials: DM
authors.lastname: Ruiz
authors.forename: Daniel O
authors.initials: DO
authors.lastname: Bennardi
authors.forename: Erlinda
authors.initials: E
authors.lastname: Del Valle Ortiz
authors.forename: Juan C
authors.initials: JC
authors.lastname: Autino
mesh_terms: D000818:Animals; D002384:Catalysis; D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry; D007306:Insecticides / Q000138:chemical synthesis* / Q000737:chemistry; D021281:Quantitative Structure-Activity Relationship; D018411:Spodoptera
chemical_list: D005419:Flavonoids; D007306:Insecticides