title: Tumor necrosis factor-alpha and its receptors in epithelial ovarian cancer.
abstract: The aim of the present study was to characterize the expression pattern of tumor necrosis factor (TNF)-alpha and its receptors (TNF-Rs) in the epithelial ovarian cancer (EOC) and compare these results with the outcome of 126 patients. Presence of TNF-alpha, TNFR-1 and TNFR-2 were studied by Western blotting and immunohistochemistry. The proportion of samples positive for TNF-alpha and TNF-R2 was higher in epithelial ovarian cancer patients than in benign ovarian diseases (p<0.001 and p=0.016, respectively). Immunostaining intensity of TNF-R2 were correlated with tumor stage (p<0.001) and with reduced mean survival time (MST) (p=0.002). The results of the present study suggested that tissue expression of TNF-R2 in epithelial ovarian cancer was correlated with the highest risk of cancer progression. Thus, the clinical value of activated TNF system in epithelial ovarian cancer needs to be further investigated.
authors.affiliation: Department of Obstetrics, Gynecology and Obstetrics/Gynecological Care, Medical University of Bialystok, Bialystok, Poland. bdobrzycka@gmail.com
authors.forename: Bozena
authors.initials: B
authors.lastname: Dobrzycka
authors.forename: Slawomir J
authors.initials: SJ
authors.lastname: Terlikowski
authors.forename: Magdalena
authors.initials: M
authors.lastname: Garbowicz
authors.forename: Wieslawa
authors.initials: W
authors.lastname: Niklińska
authors.forename: Piotr S
authors.initials: PS
authors.lastname: Bernaczyk
authors.forename: Jacek
authors.initials: J
authors.lastname: Nikliński
authors.forename: Maciej
authors.initials: M
authors.lastname: Kinalski
authors.forename: Lech
authors.initials: L
authors.lastname: Chyczewski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018450:Disease Progression; D005260:Female; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism / Q000473:pathology; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000378:metabolism*; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D055815:Young Adult
chemical_list: D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D014409:Tumor Necrosis Factor-alpha