title: Assessment of sleep disturbance in renal transplant recipients and associated risk factors.
abstract: Sleep disturbances are highly prevalent in ESRD patients. In this study we sought to evaluate the associations of poor sleep with several genetic, laboratory, treatment and demographic factors in renal allograft recipients using a validated sleep quality questionnaire. A cross-sectional study was conducted on renal transplant patients over 18 years of age with stable current stable graft function. All patients completed PSQI and Ifudu questionnaires for assessment of sleep quality and morbidity measures. Kolmogorov-Smirnov test was used for evaluation of distributions besides Student's t-test, and Fisher's exact test for analyses. Mean total PSQI score for the whole patients was 6.5 +/- 2.6. Overall 26 (67%) of patients were diagnosed as "poor sleepers" (PSQI total score > or =5) and the reminding 13 (33%) were "good sleepers". Compared to "good sleepers", "poor sleepers" significantly had higher serum phosphate levels and ESRD duration (P = 0.05). Hematological disorders were more seen in "poor sleepers" and musculoskeletal disorders had a significant worsening impact on PSQI total score (beta = 0.28, P = 0.05). In conclusion our study showed that sleep disturbance is common in renal transplant patients is surprisingly common, and ESRD duration prior to transplant was significantly associate with sleep quality. Future studies with larger sample sizes are necessary for confirming our results.
authors.affiliation: Dr. Taheri Medical Research Group, Baqiyatallah Research Center for Gastroenterology and Liver Disease, Baqiyatallah University of Medical Sciences, Tehran, Iran.
authors.forename: Vahid
authors.initials: V
authors.lastname: Pourfarziani
authors.forename: Saeed
authors.initials: S
authors.lastname: Taheri
authors.forename: Mir Mohsen
authors.initials: MM
authors.lastname: Sharifi-Bonab
authors.forename: Maqsud
authors.initials: M
authors.lastname: Mohammadzadeh
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006402:Hematologic Diseases / Q000150:complications; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009140:Musculoskeletal Diseases / Q000150:complications; D010710:Phosphates / Q000097:blood; D018570:Risk Assessment; D012307:Risk Factors; D012890:Sleep; D012893:Sleep Wake Disorders / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D011795:Surveys and Questionnaires; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D010710:Phosphates