Gemcitabine and other new cytotoxic drugs: will any find their way into primary therapy?
Primary treatment for classic Hodgkin lymphoma (HL) remains highly effective with chemotherapy alone or combined-modality therapy. The limitations of therapy have been related to toxicity and efficacy in subsets of patients. The introduction of a number of new and novel cytotoxic agents has provided opportunities for investigating their use in the treatment of HL. This article briefly reviews current primary treatment strategies for HL and examines the existing data for both new cytotoxic agents and other selected novel agents in the treatment of HL.
Dougherty
David W
DW
James P. Wilmot Cancer Center, Division of Hematology/Oncology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 704, Rochester, NY 14642, USA.
Friedberg
Jonathan W
JW
D000911:Antibodies, Monoclonal / Q000627:therapeutic use / Q000633:toxicity; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D000069461:Bendamustine Hydrochloride; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D056572:Histone Deacetylase Inhibitors / Q000627:therapeutic use / Q000633:toxicity; D006689:Hodgkin Disease / Q000628:therapy*; D006801:Humans; D000077269:Lenalidomide; D009588:Nitrogen Mustard Compounds / Q000627:therapeutic use / Q000633:toxicity; D000069283:Rituximab; D013792:Thalidomide / Q000031:analogs & derivatives / Q000627:therapeutic use / Q000633:toxicity; D014747:Vinblastine / Q000031:analogs & derivatives / Q000627:therapeutic use / Q000633:toxicity; D000077235:Vinorelbine; D000093542:Gemcitabine
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D056572:Histone Deacetylase Inhibitors; D009588:Nitrogen Mustard Compounds; D003841:Deoxycytidine; D000069283:Rituximab; D013792:Thalidomide; D014747:Vinblastine; D000069461:Bendamustine Hydrochloride; D000077269:Lenalidomide; D000077235:Vinorelbine; D000093542:Gemcitabine