title: Chemical synthesis and characterization of palm oil-based difatty acyl thiourea.
abstract: Difatty acyl thiourea (DFAT), which has biological activities as antibiotics and antifungal, has been synthesized from palm oil and thiourea using sodium ethoxide as catalyst. Ethyl fatty ester (EFE) and glycerol were produced as by-products. The synthesis was carried out by reflux palm oil with thiourea in ethanol. In this process, palm oil converted to about 81% pure DFAT after 11 hour and molar ratio of thiourea to palm oil was 6.0: 1 at 78 degrees C. Elemental analysis, Fourier transform iInfrared (FTIR) spectroscopy and (1)H nuclear magnetic resonance (NMR) technique were used to characterize both DFAT and EFE.
authors.affiliation: Department of Chemistry, Faculty of Science, Universiti Putra Malaysia. wisam92@yahoo.com
authors.forename: Wisam H
authors.initials: WH
authors.lastname: Hoidy
authors.forename: Mansor B
authors.initials: MB
authors.lastname: Ahmad
authors.forename: Emad A Jaffar
authors.initials: EA
authors.lastname: Al-Mulla
authors.forename: Wan Zin Wan
authors.initials: WZ
authors.lastname: Yunus
authors.forename: Nor azowa Bt
authors.initials: Na
authors.lastname: Ibrahim
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D000431:Ethanol / Q000031:analogs & derivatives / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D000073878:Palm Oil; D010938:Plant Oils / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013890:Thiourea / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000935:Antifungal Agents; D004952:Esters; D005227:Fatty Acids; D010938:Plant Oils; C098088:sodium ethoxide; D000431:Ethanol; D000073878:Palm Oil; D013890:Thiourea