title: Change in renal function after sodium phosphate preparation for screening colonoscopy.
abstract: OBJECTIVE
  To investigate the changes in renal function at 12-24 mo in patients following sodium phosphate (NaP) preparation for screening colonoscopy.
  
  
  METHODS
  We carried out a retrospective study on the results from patients who received health check-up services as part of an employer-provided wellness program performed between August 2006 and May 2008 and who were followed up for 12-24 mo. Prior to screening colonoscopy, 224 patients underwent bowel cleansing with NaP (NaP group) and 113 patients with polyethylene glycol (PEG group). The control group comprised 672 age-matched patients. We compared the changes in the creatinine levels and the glomerular filtration rates (GFRs) from baseline to 12-24 mo between the NaP, PEG, and control groups using two-way repeated measured analysis of variance. In addition, multivariate linear regression analysis was performed to assess the risk factors for a decreased GFR.
  
  
  RESULTS
  The baseline mean serum creatinine level in the NaP, PEG, and control groups was 1.12 +/- 0.15, 1.12 +/- 0.16, and 1.12 +/- 0.15 mg/dL, which increased to 1.15 +/- 0.15, 1.15 +/- 0.18, and 1.15 +/- 0.15 mg/dL, respectively, after 12-24 mo. The baseline mean GFR in the NaP, PEG, and control groups was 69.0 +/- 7.7, 68.9 +/- 8.0, and 69.6 +/- 6.7 mL/min per 1.73 m(2), which decreased to 66.5 +/- 7.8, 66.5 +/- 8.3, and 67.4 +/- 6.4 mL/min per 1.73 m(2), respectively, after 12-24 mo. The changes in serum creatinine levels and GFRs were not significantly between the NaP, PEG, and control groups (P = 0.992 and P = 0.233, respectively). Using multivariate linear regression analysis, only the baseline GFR was associated with the change in GFR (P < 0.001). Indeed, the bowel preparations were not associated with the change in GFR (P = 0.297).
  
  
  CONCLUSIONS
  NaP bowel preparation in subjects with normal renal function was not associated with renal injury, and NaP can thus be used safely for screening colonoscopy.
authors.affiliation: Healthcare Center, Konkuk University Medical Center, Department of Internal Medicine, Konkuk University School of Medicine, Medical Immunology Center, Institute of Biomedical Science and Technology, 4-12 Hwayang-dong, Gwangjin-gu, Seoul, South Korea.
authors.forename: Dong Choon
authors.initials: DC
authors.lastname: Seol
authors.forename: Sung Noh
authors.initials: SN
authors.lastname: Hong
authors.forename: Jeong Hwan
authors.initials: JH
authors.lastname: Kim
authors.forename: In Kyung
authors.initials: IK
authors.lastname: Sung
authors.forename: Hyung Seok
authors.initials: HS
authors.lastname: Park
authors.forename: Jung Hyun
authors.initials: JH
authors.lastname: Lee
authors.forename: Chan Sup
authors.initials: CS
authors.lastname: Shim
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003113:Colonoscopy / Q000379:methods*; D003404:Creatinine / Q000737:chemistry; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010710:Phosphates / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000737:chemistry; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D010710:Phosphates; D011092:Polyethylene Glycols; D003404:Creatinine; C018279:sodium phosphate