title: Expression of podoplanin and calretinin in meningioma: an immunohistochemical study.
abstract: Meningioma is derived from arachnoid cells covering the surface of the brain and spinal cord, and it has characteristics shared by mesothelioma arising from the pleura and peritoneum in that it takes an epithelioid appearance despite its mesenchymal origin. We examined the immunohistochemical expression of podoplanin and calretinin, both of which are well-known markers of mesothelioma, in 24 surgical cases of meningioma of various types. In most cases, a linear immunoreactivity for podoplanin was found along the cell surface of most neoplastic cells. An intracytoplasmic, finely granular, or diffuse immunoreactivity was also noted in some cells. These findings corresponded well to immunoreactivity for epithelial membrane antigen (EMA), but immunoreactivity for podoplanin was more crisp or sharply delineated and clear compared with that for EMA. These findings indicate that podoplanin can be used as an immunohistochemical marker that is equivalent to EMA in the differential diagnosis of meningioma. However, most meningiomas did not contain calretinin-immunoreactive cells, a finding that differs from the diffuse immunoreactivity seen in mesothelioma.
authors.affiliation: Department of Pathology, Osaka Red Cross Hospital, Tennoji, Osaka 543-8555, Japan. masa-s@sings.jp
authors.forename: Masayuki
authors.initials: M
authors.lastname: Shintaku
authors.forename: Tomoko
authors.initials: T
authors.lastname: Honda
authors.forename: Tomomi
authors.initials: T
authors.lastname: Sakai
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D064032:Calbindin 2; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis*; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D008579:Meningioma / Q000175:diagnosis* / Q000378:metabolism; D018396:Mucin-1 / Q000032:analysis; D064030:S100 Calcium Binding Protein G / Q000032:analysis*; D000098853:Podoplanin
chemical_list: D014408:Biomarkers, Tumor; D064032:Calbindin 2; D008562:Membrane Glycoproteins; D018396:Mucin-1; D064030:S100 Calcium Binding Protein G; C576764:CALB2 protein, human; C117468:PDPN protein, human; D000098853:Podoplanin