[Renal effects of combined anti-hypertensive treatments].
ACE inhibitors and angiotensin receptor blockers confer renal protection in proteinuric nephropaties, but recently worsening of renal outcomes has been reported in non-proteinuric patients treated with a combination of ramipril and telmisartan, compared to ramipril only. In view of these apparently contradictory data, the review wants to shed light on treatment modalities of patients with hypertension and chronic kidney disease.
Gallieni
Maurizio
M
UO Nefrologia e Dialisi, Ospedale San Carlo Borromeo, Milano. gallieni.maurizio@sancarlo.mi.it
Olivi
Laura
L
Mezzina
Nicoletta
N
Cozzolino
Mario
M
Cusi
Daniele
D
D000577:Amides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D047228:Angiotensin II Type 1 Receptor Blockers / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000145:classification / Q000494:pharmacology* / Q000627:therapeutic use; D004232:Diuretics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D005650:Fumarates / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000150:complications / Q000517:prevention & control* / Q000652:urine; D007676:Kidney Failure, Chronic / Q000150:complications; D015201:Meta-Analysis as Topic; D009318:Natriuresis / Q000187:drug effects; D011507:Proteinuria / Q000209:etiology / Q000517:prevention & control; D016032:Randomized Controlled Trials as Topic; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced
D000577:Amides; D047228:Angiotensin II Type 1 Receptor Blockers; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D004232:Diuretics; D005650:Fumarates; C446481:aliskiren