title: Multivariate tensor-based brain anatomical surface morphometry via holomorphic one-forms.
abstract: Here we introduce multivariate tensor-based surface morphometry using holomorphic one-forms to study brain anatomy. We computed new statistics from the Riemannian metric tensors that retain the full information in the deformation tensor fields. We introduce two different holomorphic one-forms that induce different surface conformal parameterizations. We applied this framework to 3D MRI data to analyze hippocampal surface morphometry in Alzheimer's Disease (AD; 26 subjects), lateral ventricular surface morphometry in HIV/AIDS (19 subjects) and cortical surface morphometry in Williams Syndrome (WS; 80 subjects). Experimental results demonstrated that our method powerfully detected brain surface abnormalities. Multivariate statistics on the local tensors outperformed other TBM methods including analysis of the Jacobian determinant, the largest eigenvalue, or the pair of eigenvalues, of the surface Jacobian matrix.
authors.affiliation: Lab. of Neuro Imaging, UCLA School of Medicine, Los Angeles, CA 90095, USA. ylwang@loni.ucla.edu
authors.forename: Yalin
authors.initials: Y
authors.lastname: Wang
authors.forename: Tony F
authors.initials: TF
authors.lastname: Chan
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Toga
authors.forename: Paul M
authors.initials: PM
authors.lastname: Thompson
mesh_terms: D000465:Algorithms; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000473:pathology*; D003627:Data Interpretation, Statistical; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015999:Multivariate Analysis; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity