Butyrylcholinesterase and diabetes mellitus in the CHE2 C5- and CHE2 C5+ phenotypes.
OBJECTIVE
To investigate the relationship between butyrylcholinesterase (BChE) activities (total and band specific) and diabetes mellitus.


METHODS
BChE activities (BChEA, AC(4/5), AC(OF) and RC(5)) were analyzed in 101 type 1 (DM1) and in 145 type 2 (DM2) diabetic patients, in relation to phenotype, weight and incidence of metabolic syndrome (MS) in these patients. The C(4/5) and C(5) complex were separated from other molecular forms (C(OF)) using an acid agar gel.


RESULTS
The BChE activity (BChEA) and the absolute activities of C(4/5) (AC(4/5)) and C(OF) (AC(OF)) showed a high positive correlation coefficient to weight in the CHE2 C5- group, while the relative activity of C5 complex (RC5) showed a negative correlation to weight.


CONCLUSIONS
The present study suggests that the positive correlation of the BChE activities to diabetes mellitus and to insulin resistance may depend on the CHE2 locus variability. High values of BChE activities were associated with insulin resistance only in CHE2 C5- diabetic patients, while in CHE2 C5+ diabetic patients, the presence of C(5) complex, especially in a relatively high proportion, leads to less fat storage and better protection against metabolic syndrome.
Cwiertnia
Mauro M
MM
Departamento de Patologia Médica, Universidade Federal do Paraná, Curitiba, PR, Brasil.
Alcântara
Vânia M
VM
Réa
Rosângela R
RR
Faria
Ana Cristina R A
AC
Picheth
Geraldo
G
Scartezini
Marileia
M
Graef
Lorena E
LE
Welter
Marciane
M
D000328:Adult; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D002091:Butyrylcholinesterase / Q000097:blood* / Q000235:genetics; D016022:Case-Control Studies; D002802:Cholinesterases / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000201:enzymology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000201:enzymology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood; D008875:Middle Aged; D010641:Phenotype; D012044:Regression Analysis
C116697:cholinesterase 2; D002091:Butyrylcholinesterase; D002802:Cholinesterases