Putative respiratory chain of Porphyromonas gingivalis.
The electron transfer chain in Porphyromonas gingivalis, or periodontopathogens, has not yet been characterized. P. gingivalis, a strict anaerobic bacteria and the second colonizer of the oral cavity, is considered to be a major causal agent involved in periodontal diseases. Primary colonizers create a favorable environment for P. gingivalis growth by decreasing oxygen pressure. Oxygen does not appear to be the final electron acceptor of the respiratory chain. Fumarate and cytochrome b have been implicated as major components of the respiratory activity. However, the P. gingivalis genome shows many other enzymes that could be implicated in aerobic or nitrite respiration. Using bioinformatic tools and literature studies of respiratory pathways, the ATP synthesis mechanism from the sodium cycle and nutrients metabolism, the putative respirasome of P. gingivalis has been proposed.
Meuric
Vincent
V
Equipe de Microbiologie, UPRES-EA 1254, Université Européenne de Bretagne, Université de Rennes I, UFR Odontologie, Bâtiment 15, 2 Avenue du Professeur Léon Bernard, 35043 Rennes Cedex, France.
Rouillon
Astrid
A
Chandad
Fatiha
F
Bonnaure-Mallet
Martine
M
D000255:Adenosine Triphosphate / Q000378:metabolism*; D003573:Cytochrome b Group / Q000378:metabolism*; D004579:Electron Transport; D004734:Energy Metabolism; D005650:Fumarates / Q000378:metabolism*; D006801:Humans; D010084:Oxidation-Reduction; D016966:Porphyromonas gingivalis / Q000378:metabolism*
D003573:Cytochrome b Group; D005650:Fumarates; D000255:Adenosine Triphosphate