title: Effect of two doses of caffeine on muscular function during isokinetic exercise.
abstract: Studies provide equivocal results regarding the ergogenic properties of caffeine during high-intensity exercise.
  
  
  OBJECTIVE
  The primary aim of this study was to examine the effects of two doses of caffeine on peak/average torque, power output, and total work of the knee extensors and flexors during two bouts of high-intensity exercise.
  
  
  METHODS
  Fifteen active men (mean age = 26.4 ± 3.9 yr and body mass = 82.7 ± 2.9 kg) initially completed a familiarization bout on the isokinetic dynamometer, followed by three subsequent trials separated by at least 48 h. Exercise consisted of two bouts of 40 repetitions of maximal knee extension and flexion of the dominant leg at a contraction velocity equal to 180°·s. Before each trial, subjects abstained from caffeine intake and intense exercise for 48 h. Treatment order (5 and 2 mg·kg of anhydrous caffeine or placebo) was randomly assigned to subjects using a single-blind, randomized, counterbalanced, crossover design. A 3 (treatment) × 2 (sets) ANOVA with repeated measures was used to detect differences in performance across treatment and time.
  
  
  RESULTS
  Compared with placebo, caffeine significantly (P < 0.05) enhanced peak knee flexion torque, knee extension/flexion total work, and knee extension/flexion power in bout 1 with no effect in bout 2. Only the 5-mg·kg dose of caffeine improved performance, with the magnitude of performance improvement ranging from 5% to 8%.
  
  
  CONCLUSIONS
  Data suggest that a relatively high (5-mg·kg body weight) but not low (2-mg·kg body weight) caffeine dose is ergogenic for maximal knee extension/flexion exercise.
authors.affiliation: Department of Kinesiology, California State University-San Marcos, San Marcos, CA 92096-0001, USA. astorino@csusm.edu
authors.forename: Todd A
authors.initials: TA
authors.lastname: Astorino
authors.forename: Michael N
authors.initials: MN
authors.lastname: Terzi
authors.forename: Daniel W
authors.initials: DW
authors.lastname: Roberson
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Burnett
mesh_terms: D000328:Adult; D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D018763:Muscle Fatigue / Q000187:drug effects / Q000502:physiology; D018482:Muscle, Skeletal / Q000187:drug effects*; D055070:Resistance Training / Q000379:methods; D019415:Torque; D014481:United States; D055815:Young Adult
chemical_list: D000697:Central Nervous System Stimulants; D002110:Caffeine