Association study between RGS4 and bipolar disorder in the Chinese Han population.
This abstract concerns a brief association study between RGS4 and bipolar disorder, by an association study of five single nucleotide polymorphisms, rs951436, rs951439, rs2842030, rs2661319, and rs2344671, in 484 patients and 288 controls from the Chinese Han population. In our case-control study, the T allele of the single nucleotide polymorphism rs951436 tended to be protective (P=0.0078), and in addition, a haplotype containing this T allele was also protective for bipolar disorder (P=0.02). Our results provide further evidence to support RGS4 as a potential susceptible gene for bipolar disorder.
Li
You
Y
Bio-X Center and affiliated Changning Mental Health Center, Shanghai Jiao Tong University, Jiulong, Matang District, Wuhu, China.
Zhao
Qian
Q
Zhang
Zhao
Z
Wang
Peng
P
Che
Ronglin
R
Tang
Wei
W
Feng
Guoyin
G
Lindpaintner
Klaus
K
He
Lin
L
Shi
YongYong
Y
D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001714:Bipolar Disorder / Q000235:genetics*; D002681:China; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D015894:Genome, Human / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D020710:RGS Proteins / Q000235:genetics*
D020710:RGS Proteins; C098799:RGS4 protein