Diastereoselective Synthesis of trans-beta-Lactams Using a Simple Multifunctional Catalyst.
A catalytic, highly diastereoselective process for the synthesis of trans-beta-lactams is reported. This system is based on a phosphonium fluoride precatalyst that both activates the nucleophile and directs the reaction process for high yield and diastereoselectivity.
Abraham
Ciby J
CJ
Department of Chemistry, New Chemistry Building, Johns Hopkins University, 3400 North Charles Street, Baltimore, Maryland 21218, USA.
Paull
Daniel H
DH
Dogo-Isonagie
Cajetan
C
Lectka
Thomas
T