[A mathematical model of paracrine regulation of the proliferative activity of epidermis with the participation of T-lymphocytes].
A mathematical model of paracrine regulation of the proliferative activity of epidermis in the foci of skin lesions in psoriatic patients is presented. The model simulates the participation of skin-infiltrating activated T-lymphocytes as cellular regulators of apoptosis of proliferating keratinocytes. It allows one to describe all basic phases of the development of the focus of psoriatic lesion: the beginning of formation, a long stable or periodic manifestation, and the resolution of lesion and its involution to clinically uninvolved and normal skin. The model shows also the possibility of a spasmodic (triggering) transition of a pathological focus of lesion from the condition of remission to a new exacerbation and vice versa, which is a characteristic feature of the disease.
Laptev
M V
MV
Nikulin
N K
NK
D000818:Animals; D017209:Apoptosis / Q000276:immunology; D049109:Cell Proliferation; D004817:Epidermis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D015603:Keratinocytes / Q000276:immunology / Q000473:pathology; D018448:Models, Immunological; D019899:Paracrine Communication / Q000276:immunology*; D011565:Psoriasis / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology