title: Small molecule-mediated inhibition of translation by targeting a native RNA G-quadruplex.
abstract: Herein, we show that a naturally occurring RNA G-quadruplex element within the 5' UTR of the human NRAS proto-oncogene is a target for a small molecule that inhibits translation in vitro. The present study provides a first demonstration that natural 5' UTR mRNA G-quadruplexes have potential as molecular targets for small molecules that modulate translation.
authors.affiliation: Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UKCB2 1EW.
authors.forename: Anthony
authors.initials: A
authors.lastname: Bugaut
authors.forename: Raphaël
authors.initials: R
authors.lastname: Rodriguez
authors.forename: Sunita
authors.initials: S
authors.lastname: Kumari
authors.forename: Shang-Te Danny
authors.initials: ST
authors.lastname: Hsu
authors.forename: Shankar
authors.initials: S
authors.lastname: Balasubramanian
mesh_terms: D020121:5' Untranslated Regions; D001483:Base Sequence; D054856:G-Quadruplexes; D008024:Ligands; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D000090063:Proto-Oncogene Mas; D012313:RNA / Q000737:chemistry*; D012333:RNA, Messenger / Q000737:chemistry / Q000378:metabolism
chemical_list: D020121:5' Untranslated Regions; D008024:Ligands; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger; D012313:RNA