[Research on apoptosis changes of tensor veli palatini in patients with obstructive sleep apnea-hypopnea syndrome].
OBJECTIVE
To explore apoptosis changes of dilator muscles in the upper airway by detecting the expression of Bax, Bcl-2 in tensor veli palatini in patients with OSAHS.


METHODS
The expression of Bax and Bcl-2 were detected in tensor veli palatini in 30 cases with OSAHS and 10 cases chronic tonsillitis without OSAHS by immunohistochemistry and image analytical system, and the results were analyzed.


RESULTS
(1) The expression levels of Bax in the OSAHS group increased significantly compared to control group (P < 0.05), but there were no significant differences of Bcl-2 expression between two groups, the ratio of Bax/Bcl-2 increased significantly (P < 0.05). (2) There were positive correlations between AHI and the expression levels of Bax (r = 0.697, P < 0.01) respectively in the test group.


CONCLUSIONS
The results indicate that apoptosis occurred in tensor veli palatini in patients with OS AHS, and the more severity of OSAHS, the more apoptosis.
Gong
Hongxun
H
Department of Otolaryngology Head and Neck Surgery, Fuzhou General Hospital of PLA Nanjing Military Region, Fuzhou, 350025, China.
Chen
Xianming
X
Zhang
Xian
X
Liu
Fengfang
F
D000328:Adult; D000403:Airway Resistance; D016022:Case-Control Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010156:Palatal Muscles / Q000378:metabolism / Q000473:pathology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D020181:Sleep Apnea, Obstructive / Q000378:metabolism / Q000473:pathology*; D055815:Young Adult; D051028:bcl-2-Associated X Protein / Q000378:metabolism
C494826:BAX protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein