An extended motor network generates beta and gamma oscillatory perturbations during development.
This study examines the time course and neural generators of oscillatory beta and gamma motor responses in typically-developing children. Participants completed a unilateral flexion-extension task using each index finger as whole-head magnetoencephalography (MEG) data were acquired. These MEG data were imaged in the frequency-domain using spatial filtering and the resulting event-related synchronizations and desynchronizations (ERS/ERD) were subjected to voxel-wise statistical analyses to illuminate time-frequency specific activation patterns. Consistent with adult data, these children exhibited a pre-movement ERD that was strongest over the contralateral post-central gyrus, and a post-movement ERS response with the most prominent peak being in the contralateral precentral gyrus near premotor cortices. We also observed a high-frequency (approximately 80 Hz) ERS response that coincided with movement onset and was centered on the contralateral precentral gyrus, slightly superior and posterior to the beta ERS. In addition to pre- and post-central gyri activations, these children exhibited beta and gamma activity in supplementary motor areas (SMA) before and during movement, and beta activation in cerebellar cortices before and after movement. We believe the gamma synchronization may be an excellent candidate signal of basic cortical motor control, as the spatiotemporal dynamics indicate the primary motor cortex generates this response (and not the beta oscillations) which is closely yoked to the initial muscle activation. Lastly, these data suggest several additional neural regions including the SMA and cerebellum are involved in basic movements during development.
Wilson
Tony W
TW
Center for Magnetoencephalography, University of Nebraska Medical Center, Omaha, NE 68198, USA. Tony.W.Wilson@gmail.com
Slason
Erin
E
Asherin
Ryan
R
Kronberg
Eugene
E
Reite
Martin L
ML
Teale
Peter D
PD
Rojas
Donald C
DC
D000293:Adolescent; D001611:Beta Rhythm; D001921:Brain / Q000254:growth & development* / Q000502:physiology*; D001931:Brain Mapping; D002648:Child; D003344:Cortical Synchronization; D004525:Efferent Pathways / Q000502:physiology; D019054:Evoked Potentials, Motor; D005260:Female; D005385:Fingers / Q000254:growth & development* / Q000502:physiology*; D007839:Functional Laterality; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D009068:Movement / Q000502:physiology*; D010507:Periodicity; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors