gammadelta T-cells: basic features and potential role in vasculitis.
gammadelta T-cells are a numerically small subset of T-cells with distinct features. They recognise antigens that are not seen by other immune cells. At the functional level, gammadelta T-cells share some features with alphabeta T-cells but also exert functions that are otherwise performed by specialised subsets of alphabeta T-cells (e.g. IL-17 production, regulatory activity). We discuss the potential role of gammadelta T-cells in various clinical forms of vasculitis.
Kabelitz
Dieter
D
Institute of Immunology, University of Kiel, Kiel, Germany. kabelitz@immunologie.uni-kiel.de
Fazio
Juliane
J
Adam-Klages
Sabine
S
Marget
Matthias
M
Oberg
Hans Heinrich
HH
Wesch
Daniela
D
Lamprecht
Peter
P
D000818:Animals; D006801:Humans; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014657:Vasculitis / Q000276:immunology*
D016692:Receptors, Antigen, T-Cell, gamma-delta