Is Hodgkin lymphoma just another B-cell lymphoma?
Hodgkin disease was the first defined lymphoid neoplasm. For many decades it was regarded as a disease separate from non-Hodgkin lymphoma. However, recent studies have shown that the dysplastic cells of Hodgkin lymphoma (HL) are monoclonal B cells. This finding raised again the question "Is HL just another B-cell lymphoma?" This article reviews the different aspects of HL and B-cell non-Hodgkin lymphoma (B-NHL), concluding that-despite the same cell of origin-fundamental differences exist in morphology, cellular composition, immunophenotype, activation or inhibition of transcription factors, epigenetics, and clinical behavior. These findings lead us to conclude that HL and B-NHLs should stay as two separate categories.
Stein
Harald
H
Pathology Institute, Campus Benjamin Franklin, Charité University of Medicine, Hindenburgdamm 30, 12200, Berlin, Germany. harald.stein@charite.de
Bob
Roshanak
R
D015703:Antigens, CD / Q000276:immunology; D001402:B-Lymphocytes / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D053263:Gene Regulatory Networks; D006689:Hodgkin Disease / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D014157:Transcription Factors / Q000235:genetics
D015703:Antigens, CD; D014157:Transcription Factors