Pancreatitis following administration of iodixanol in patients on hemodialysis: a pilot study.
OBJECTIVE
We previously described the association of pancreatitis with the use of iodixanol radiocontrast in two patients on hemodialysis. This study was designed to determine whether there might be a causal link.


METHODS
30 consecutive hemodialysis patients without predisposition for pancreatitis who were undergoing de-clotting and angioplasty of their arteriovenous access were randomly assigned to either iodixanol or iohexol radiocontrast.


RESULTS
The demographics and volume of contrast used were similar between the groups. 2 of the 15 patients who received iodixanol developed elevations in serum amylase and lipase as well as signs and symptoms of pancreatitis. No patient who received iohexol developed pancreatitis.


CONCLUSIONS
The use of iodixanol appears to be associated with pancreatitis in a small population of hemodialysis patients. Although the pathogenesis of iodixanol-induced pancreatitis is unclear, we speculate that it is possibly related to the hyperviscosity of this agent, which may decrease pancreatic blood flow. Larger studies are needed to verify these findings.
Kheda
M
M
Section of Nephrology, Medical College of Georgia, Augusta, GA, USA.
Brenner
L
L
Riggans
D
D
Kota
V
V
Szerlip
H M
HM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000681:Amylases / Q000378:metabolism; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007472:Iohexol / Q000009:adverse effects; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging / Q000201:enzymology* / Q000628:therapy*; D008049:Lipase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000139:chemically induced / Q000175:diagnosis / Q000453:epidemiology*; D010865:Pilot Projects; D011859:Radiography; D006435:Renal Dialysis; D014283:Triiodobenzoic Acids / Q000009:adverse effects*
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; D008049:Lipase; D000681:Amylases; C044834:iodixanol