title: Automation in the high-throughput selection of random combinatorial libraries--different approaches for select applications.
abstract: Automation in combination with high throughput screening methods has revolutionised molecular biology in the last two decades. Today, many combinatorial libraries as well as several systems for automation are available. Depending on scope, budget and time, a different combination of library and experimental handling might be most effective. In this review we will discuss several concepts of combinatorial libraries and provide information as what to expect from these depending on the given context.
authors.affiliation: Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Ihnestr. 63-73, Berlin, Germany. gloekler@molgen.mpg.de
authors.forename: Jörn
authors.initials: J
authors.lastname: Glökler
authors.forename: Tatjana
authors.initials: T
authors.lastname: Schütze
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Konthur
mesh_terms: D057205:Automation, Laboratory; D020650:Combinatorial Chemistry Techniques; D057166:High-Throughput Screening Assays; D019151:Peptide Library; D012371:Robotics; D052156:SELEX Aptamer Technique; D054852:Small Molecule Libraries / Q000737:chemistry*
chemical_list: D019151:Peptide Library; D054852:Small Molecule Libraries