Enantioselective protonation.
Enantioselective protonation is a common process in biosynthetic sequences. The decarboxylase and esterase enzymes that effect this valuable transformation are able to control both the steric environment around the proton acceptor (typically an enolate) and the proton donor (typically a thiol). Recently, several chemical methods to achieve enantioselective protonation have been developed by exploiting various means of enantiocontrol in different mechanisms. These laboratory transformations have proven useful for the preparation of a number of valuable organic compounds.
Mohr
Justin T
JT
Arnold and Mabel Beckman Laboratories of Chemical Synthesis, Department of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, Mail Code 164-30, Pasadena, CA 91125, USA.
Hong
Allen Y
AY
Stoltz
Brian M
BM
D004798:Enzymes / Q000378:metabolism; D006859:Hydrogen / Q000737:chemistry; D011522:Protons; D013237:Stereoisomerism; D013379:Substrate Specificity
D004798:Enzymes; D011522:Protons; D006859:Hydrogen