[Histone demethylase LSD1 and its biological functions].
Discovery of histone lysine specific demethylase 1 (LSD1) indicates that even histone methylation is reversible. Structural analysis shows that LSD1 is a flavin-dependent amine oxidase, which is able to catalyze the specific removal of methyl groups from mono- and dimethylated Lys4 and Lys9 of histone H3. Functional studies demonstrate that LSD1 regulates activation and inhibition of gene transcription in the nucleus, which is known as the innermost gene switch of cells. LSD1 plays important roles in embryonic development and tumorigenesis. Here, we review recent insights into the structure and chemical mechanism of LSD1, and its regulatory roles in development and cancer.
Shao
Gen-Bao
GB
Institute of Basic Medical Science, School of Medicine, Jiangsu University, Zhenjiang 212013, China. gbshao07@ujs.edu.cn
Huang
Xiao-Jia
XJ
Gong
Ai-Hua
AH
Zhang
Zhi-Jian
ZJ
Lu
Rong-Zhu
RZ
Sang
Jian-Rong
JR
D000818:Animals; D047108:Embryonic Development; D056466:Histone Demethylases / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology
D056466:Histone Demethylases