A chromone from Seseli praecox (Apiaceae).
Chemical investigation of the stems of Seseli praecox (Gamisans) Gamisans, an endemic Apiaceae from Sardinia, afforded an isopropenylated chromone (5-hydroxy-6-(2-Z-butenyl-3-hydroxymethyl)-7-methoxy-2-methylchromone), along with four known linear furocoumarins and their natural precursor. For biological characterization the new compound was screened against four cancer cell lines in vitro and showed differential microM antiproliferative effects between suspension and adherent cells.
Leonti
Marco
M
Dipartimento Farmaco Chimico Tecnologico, Università di Cagliari, Facoltà di Farmacia, Cagliari (CA), Italy. marcoleonti@netscape.net
Casu
Laura
L
Solinas
Maria Novella
MN
Cottiglia
Filippo
F
Caboni
Pierluigi
P
Floris
Costantino
C
Gertsch
Juerg
J
Saba
Anna Rita
AR
D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019661:Apiaceae / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D019169:Jurkat Cells; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
D000970:Antineoplastic Agents; D002867:Chromones