title: T-lymphoblastic leukemia/lymphoma: a single center retrospective study of outcome.
abstract: T-lymphoblastic leukemia/lymphoma (LBL and ALL) is a rare lymphoid malignancy typically presenting in adolescent and young adult males. Patients are traditionally treated with ALL-type protocols, with no consensus on the role of maintenance therapy, or allogeneic or autologous transplant. Outcome results are thus difficult to interpret. The successful use of intensified ALL protocols in patients <25 years with lymphoblastic malignancies without transplant prompted the Haematology Unit at St James's Hospital (SJH) to change practice in 2005 from transplanting in first complete remission (CR1) to treating patients <25 years with chemotherapy alone. We reviewed the outcome of patients treated before 2005 in order to compare the pre- and post-2005 management approaches in the future. This retrospective study included 31 patients with T-LBL treated from 1980 to 2004. The patients were divided into group A (16-25 years) and group B (>25 years). Twenty-one patients had an allograft in CR1 (group A, n = 12 and group B, n = 9). For the allografted patients the 5-year EFS and OS was 57%, with a treatment related mortality of 10%. In conclusion, this series confirms that allograft in CR1 has an acceptable cure rate, and we will use these results to benchmark outcomes using pediatric-type protocols in the future.
authors.affiliation: National Stem Cell Transplant Unit (Adults), Department of Haematology, St James's Hospital and Academic Department of Haematology, Trinity College Dublin, Dublin, Ireland. afortune@stjames.ie
authors.forename: Anne
authors.initials: A
authors.lastname: Fortune
authors.forename: Hilary
authors.initials: H
authors.lastname: O'Leary
authors.forename: Ruth
authors.initials: R
authors.lastname: Gilmore
authors.forename: Nick
authors.initials: N
authors.lastname: Chadwick
authors.forename: Lorraine
authors.initials: L
authors.lastname: Brennan
authors.forename: Mairead
authors.initials: M
authors.lastname: Ní Chonghaile
authors.forename: Shaun R
authors.initials: SR
authors.lastname: McCann
authors.forename: Paul V
authors.initials: PV
authors.lastname: Browne
authors.forename: Eibhlin
authors.initials: E
authors.lastname: Conneally
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Vandenberghe
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012189:Retrospective Studies; D016896:Treatment Outcome; D055815:Young Adult