Postprandial lipoproteins and cardiovascular disease risk in diabetes mellitus.
Diabetes mellitus is associated with increased risk for atherosclerotic cardiovascular disease (CVD). Recent prospective studies in healthy individuals suggest that the postprandial triglyceride (TG) level is a better independent predictor for assessing future CVD events than fasting TG levels. In contrast, results have been more controversial among diabetic patients, as some studies report a positive association between postprandial TG and CVD. This raises the issue of to what extent postprandial TG levels may be of predictive value in the diabetic population. One possibility impacting on the predictive power of postprandial TG in identifying CVD risk may be the presence of other risk factors, including alterations in lipid and lipoprotein metabolism, which could make it more difficult to identify the impact of postprandial lipemia on cardiovascular risk. The findings provide a challenge to develop a better approach to assess the impact of postprandial lipemia on CVD risk under diabetic conditions.
Enkhmaa
Byambaa
B
Department of Medicine, UCD Medical Center, CTSC, University of California, Davis, 2921 Stockton Boulevard, Suite 1400, Sacramento, CA 95817, USA.
Ozturk
Zeynep
Z
Anuurad
Erdembileg
E
Berglund
Lars
L
D002318:Cardiovascular Diseases / Q000150:complications*; D048909:Diabetes Complications / Q000378:metabolism* / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000503:physiopathology; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism*; D019518:Postprandial Period / Q000502:physiology*; D012307:Risk Factors
D008074:Lipoproteins