title: Organisation and dynamics of antigen receptors: implications for lymphocyte signalling.
abstract: In contrast to the fluid mosaic model proposed by Singer and Nicolson over thirty years ago, the emergent paradigm is one of plasma membrane compartmentalisation mediated by protein-protein interactions, differences in lipid composition, and interactions with the underlying actin cytoskeleton. Extensive research has focused on examining the distribution and organisation of cell surface receptors upon ligand binding; however, relatively little is known about the steady-state organisation and dynamics of cell surface proteins. Here, we discuss recent findings on the regulation of steady-state organisation and diffusion dynamics of immunoreceptors, and how this might impact on our understanding of basal and ligand-dependent signalling.
authors.affiliation: London Research Institute, Cancer Research UK, London, UK. bebhinn.treanor@cancer.org.uk
authors.forename: Bebhinn
authors.initials: B
authors.lastname: Treanor
authors.forename: Facundo D
authors.initials: FD
authors.lastname: Batista
mesh_terms: D002462:Cell Membrane / Q000378:metabolism*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D011946:Receptors, Antigen / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D008565:Membrane Proteins; D011946:Receptors, Antigen