Efficient, mild and completely regioselective synthesis of substituted pyridines.
Addition of Grignard reagents to pyridine N-oxides in THF at low temperature (-78 to -20 degrees C) and treatment with TFAA provides an efficient general procedure for synthesis of substituted pyridines. The method is compatible with a range of functional groups such as esters, halogens and nitriles.
Andersson
Hans
H
Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden.
Banchelin
Thomas Sainte-Luce
TS
Das
Sajal
S
Olsson
Roger
R
Almqvist
Fredrik
F
D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature
D009942:Organometallic Compounds; D011725:Pyridines