Association of plasma selenium concentrations with total IGF-1 among older community-dwelling adults: the InCHIANTI study.
OBJECTIVE
Insulin-like growth factor (IGF-1) stimulates cell proliferation and inhibits cell apoptosis. Recent studies underline its importance as anabolic hormone and nutritional marker in older individuals. IGF-1 synthesis and bioactivity are modulated by nutritional factors including selenium intake. However, whether circulating IGF-1 levels are positively influenced by plasma selenium, one of the most important human antioxidants, is still unknown.


METHODS
Selenium and total IGF-1 were measured in 951 men and women ≥ 65 years from the InCHIANTI study, Tuscany, Italy.


RESULTS
Means (SD) of plasma selenium and total IGF-1 were 0.95 (0.15) μmol/L and 113.4 (31.2)ng/mL, respectively. After adjustment for age and sex, selenium levels were positively associated with total IGF-1 (β±SE: 43.76±11.2, p=0.0001). After further adjustment for total energy and alcohol intake, serum alanine aminotransferase (ALT), congestive heart failure, selenium remained significantly associated with IGF-1 (β±SE: 36.7±12.2, p=0.003). The association was still significant when IL-6 was introduced in the model (β±SE: 40.1±12.0, p=0.0008).


CONCLUSIONS
We found an independent, positive and significant association between selenium and IGF-1 serum levels in community dwelling older adults.
Maggio
Marcello
M
Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy. marcellomaggio2001@yahoo.it
Ceda
Gian Paolo
GP
Lauretani
Fulvio
F
Bandinelli
Stefania
S
Dall'Aglio
Elisabetta
E
Guralnik
Jack M
JM
Paolisso
Giuseppe
G
Semba
Richard D
RD
Nouvenne
Antonio
A
Borghi
Loris
L
Ceresini
Graziano
G
Ablondi
Fabrizio
F
Benatti
Mario
M
Ferrucci
Luigi
L
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D003430:Cross-Sectional Studies; D002149:Energy Intake; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007558:Italy; D008297:Male; D012111:Residence Characteristics; D012643:Selenium / Q000097:blood* / Q000378:metabolism
D007334:Insulin-Like Growth Factor I; D012643:Selenium