title: Patient specific 4D coronary models from ECG-gated CTA data for intra-operative dynamic alignment of CTA with X-ray images.
abstract: We present an approach to derive patient specific coronary models from ECG-gated CTA data and their application for the alignment of CTA with mono-plane X-ray imaging during interventional cardiology. A 4D (3D+t) deformation model of the coronary arteries is derived by (i) extraction of a 3D coronary model at an appropriate cardiac phase and (ii) non-rigid registration of the CTA images at different ECG phases to obtain a deformation model. The resulting 4D coronary model is aligned with the X-ray data using a novel 2D+t/3D+t registration approach. Model consistency and accuracy is evaluated using manually annotated coronary centerlines at systole and diastole as reference. Improvement of registration robustness by using the 2D+t/3D+t registration is successfully demonstrated by comparison of the actual X-ray cardiac phase with the automatically determined best matching phase in the 4D coronary model.
authors.affiliation: Dept. of Medical Informatics and Radiology, Erasmus MC, Rotterdam, The Netherlands. c.metz@erasmusmc.nl
authors.forename: Coert T
authors.initials: CT
authors.lastname: Metz
authors.forename: Michiel
authors.initials: M
authors.lastname: Schaap
authors.forename: Stefan
authors.initials: S
authors.lastname: Klein
authors.forename: Lisan A
authors.initials: LA
authors.lastname: Neefjes
authors.forename: Ermanno
authors.initials: E
authors.lastname: Capuano
authors.forename: Carl
authors.initials: C
authors.lastname: Schultz
authors.forename: Robert Jan
authors.initials: RJ
authors.lastname: van Geuns
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Serruys
authors.forename: Theo
authors.initials: T
authors.lastname: van Walsum
authors.forename: Wiro J
authors.initials: WJ
authors.lastname: Niessen
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D003198:Computer Simulation; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D004562:Electrocardiography / Q000379:methods; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D010363:Pattern Recognition, Automated / Q000379:methods*; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique; D014057:Tomography, X-Ray Computed / Q000379:methods*