Ambient-temperature cobalt-catalyzed cycloaddition strategies to aromatic boronic esters.
The room-temperature cobalt-catalyzed [4 + 2] cycloaddition of alkynylboronates and 1,3-dienes provides a convenient and general method for the synthesis of benzene-based aromatic boronic esters. Two complementary aromatization strategies involving in situ elimination and DDQ oxidation were explored, with the latter finding more generality. Finally, the potential of this technique to generate highly functionalized biaryls has been demonstrated via the synthesis of chiral (racemic) DMAP catalysts.
Auvinet
Anne-Laure
AL
Department of Chemistry, University of Sheffield, Sheffield, S3 7HF, UK.
Harrity
Joseph P A
JP
Hilt
Gerhard
G