An excellent enzyme biosensor based on Sb-doped SnO2 nanowires.
Sb-doped SnO(2) nanowires were synthesized via thermal evaporation. Scanning electron microscopic, transmission electron microscopic, X-ray diffraction, current-voltage, and electrochemical impedance spectroscopy experiments have been used to characterize the structural and electrical behaviors of the nanowires. A mediator-free horseradish peroxidase-based H(2)O(2) biosensor was constructed through the Sb-doped SnO(2) nanowires used as the immobilization matrix for the enzymes. In comparison with the undoped SnO(2) nanowires, Sb-doped SnO(2) nanowires exhibited excellent electron transfer properties for the enzymes and higher electroactivity toward H(2)O(2). The biosensors displayed good performance along with high sensitivity, wide linear range, and long-term stability. Those can be attributed to the enhanced carrier density arising from Sb doping and biocompatible microenvironment provided by the Sb-doped SnO(2) nanowires. This study demonstrated that Sb-doped SnO(2) nanowires were promising platform for the construction of mediator-free biosensors and provided new further fundamental insights into the study of nanoscience and nanodevices.
Li
Limiao
L
Department of Chemistry, Key Lab of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.
Huang
Jin
J
Wang
Taihong
T
Zhang
Hao
H
Liu
Yang
Y
Li
Jinghong
J
D000965:Antimony / Q000737:chemistry*; D015374:Biosensing Techniques / Q000295:instrumentation*; D003217:Conductometry / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006735:Horseradish Peroxidase / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000032:analysis* / Q000737:chemistry; D008839:Microelectrodes; D043942:Nanotubes / Q000737:chemistry*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017971:Tin Compounds / Q000737:chemistry*
D017971:Tin Compounds; D000965:Antimony; D006861:Hydrogen Peroxide; D006735:Horseradish Peroxidase; C045358:stannic oxide