title: The effect of Rexflavone (Sophorae fructus extract) on menopausal symptoms in postmenopausal women: a randomized double-blind placebo controlled clinical trial.
abstract: To observe the protective effect of orally administrated Rexflavone (Sophorae fructus extract) for the postmenopausal symptoms, a randomized double-blind placebo controlled clinical trial was designed. Rexflavone significantly improved 11 menopausal symptoms including hot flash, which was evaluated by the modified Kupperman Index (KI), while hormone level and lipid profile were little changed by consumption. Rexflavone group significantly decreased KI score (-14.91 +/- 8.79) compared to placebo group (-11.45 +/- 6.62) as a representative index for improvement of menopausal symptoms (p < 0.05). We found that Rexflavone has no adverse effect to be safe for long term consumption. It was shown that the consumption of Rexflavone possessed beneficial effects on the postmenopausal symptoms in postmenopausal women.
authors.affiliation: RexGene Biotech. Co., Ltd. Research and Development of Life Science, Ochang, 368-831, Korea.
authors.forename: Jeongrai
authors.initials: J
authors.lastname: Lee
authors.forename: Kuk Whan
authors.initials: KW
authors.lastname: Kim
authors.forename: Hyun-Kyu
authors.initials: HK
authors.lastname: Kim
authors.forename: Soo-Wan
authors.initials: SW
authors.lastname: Chae
authors.forename: Jae-Chul
authors.initials: JC
authors.lastname: Jung
authors.forename: Suk Hyung
authors.initials: SH
authors.lastname: Kwon
authors.forename: Chul Hee
authors.initials: CH
authors.lastname: Rheu
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000342:Affective Symptoms / Q000097:blood / Q000188:drug therapy; D001007:Anxiety / Q000097:blood / Q000188:drug therapy; D019587:Dietary Supplements; D004311:Double-Blind Method; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005638:Fruit / Q000737:chemistry; D019584:Hot Flashes / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D006987:Hypesthesia / Q000097:blood / Q000188:drug therapy; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017698:Postmenopause / Q000097:blood / Q000187:drug effects*; D029909:Sophora / Q000737:chemistry*; D016896:Treatment Outcome
chemical_list: D008055:Lipids; D010936:Plant Extracts; C551319:rexflavone; D004958:Estradiol; D005640:Follicle Stimulating Hormone