Inflammasome and IL-1beta-mediated disorders.
The NLRP3 inflammasome is an intracellular complex that regulates the release of proinflammatory cytokines such as interleukin-1beta in response to exogenous pathogens and endogenous danger signals. Evidence from studies involving human genetics, human ex vivo mononuclear cell responses, and in vivo and in vitro murine models confirms the importance of the inflammasome and interleukin-1beta in the pathogenesis of several inherited and complex diseases. The availability of several effective interleukin-1beta targeted therapies has allowed for successful proof-of-concept studies in several of these disorders. However, many other diseases are likely to be mediated by the inflammasome and interleukin-1beta, providing additional targets in the future.
Hoffman
Hal M
HM
Division of Allergy and Immunology, University of California at San Diego and Rady Children's Hospital of San Diego, La Jolla, CA 92093, USA. hahoffman@ucsd.edu
Wanderer
Alan A
AA
D000818:Animals; D001195:Asbestosis / Q000188:drug therapy; D002352:Carrier Proteins / Q000276:immunology*; D056587:Cryopyrin-Associated Periodic Syndromes / Q000276:immunology; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000276:immunology; D006073:Gout / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology*; D053583:Interleukin-1beta / Q000037:antagonists & inhibitors* / Q000276:immunology*; D008171:Lung Diseases / Q000188:drug therapy; D051379:Mice; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; D012829:Silicosis / Q000188:drug therapy
D002352:Carrier Proteins; D053583:Interleukin-1beta; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human