title: Assessment of left ventricular non-compaction in adults: side-by-side comparison of cardiac magnetic resonance imaging with echocardiography.
abstract: BACKGROUND
  Two-dimensional echocardiography images obtained at end-diastole and end-systole and cardiac magnetic resonance (CMR) images obtained at end-diastole represent the three imaging methodologies validated for diagnosis of left ventricular non-compaction (LVNC). No study has compared these methodologies in assessing the magnitude of non-compaction.
  
  
  OBJECTIVE
  To compare two-dimensional echocardiography with CMR in the evaluation of patients with suspected LVNC.
  
  
  METHODS
  Sixteen patients (48+/-17 years) with LVNC underwent echocardiography and CMR within the same week. Echocardiography images obtained at end-diastole and end-systole were compared in a blinded fashion with those obtained by CMR at end-diastole to assess non-compaction in 17 anatomical segments.
  
  
  RESULTS
  All segments could be analysed by CMR, whereas only 238 (87.5%) and 237 (87.1%) could be analysed by echocardiography at end-diastole and end-systole, respectively (p=0.002). Among the analysable segments, a two-layered structure was observed in 54.0% by CMR, 42.9% by echocardiography at end-diastole and 41.4% by echocardiography at end-systole (p=0.006). Similar distribution patterns were observed with the two echocardiographic methodologies. However, compared with echocardiography, CMR identified a higher rate of two-layered structures in the anterior, anterolateral, inferolateral and inferior segments. Echocardiography at end-systole underestimated the NC/C maximum ratio compared with CMR (p=0.04) and echocardiography at end-diastole (p=0.003). No significant difference was observed between CMR and echocardiography at end-diastole (p=0.83). Interobserver reproducibility of the NC/C maximum ratio was similar for the three methodologies.
  
  
  CONCLUSIONS
  CMR appears superior to standard echocardiography in assessing the extent of non-compaction and provides supplemental morphological information beyond that obtained with conventional echocardiography.
authors.affiliation: Department of Cardiology, University of Marseille Méditerranée, 13385 Marseille cedex 05, France. franck.thuny@wanadoo.fr
authors.forename: Franck
authors.initials: F
authors.lastname: Thuny
authors.forename: Alexis
authors.initials: A
authors.lastname: Jacquier
authors.forename: Bertrand
authors.initials: B
authors.lastname: Jop
authors.forename: Roch
authors.initials: R
authors.lastname: Giorgi
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Gaubert
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Bartoli
authors.forename: Guy
authors.initials: G
authors.lastname: Moulin
authors.forename: Gilbert
authors.initials: G
authors.lastname: Habib
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D056830:Isolated Noncompaction of the Ventricular Myocardium / Q000175:diagnosis* / Q000000981:diagnostic imaging; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography; D055815:Young Adult