Giardiasis, drug resistance, and new target discovery.
Giardiasis is a worldwide parasitic disease caused by the protozoan Giardia lamblia in humans and other animals, especially live stocks. Here, we briefly review the current state of therapeutic availability for giardiasis, including chemical drugs and vaccines, and the dilemma in the prevention and treatment of this disease, including the emergence of drug resistance and the shortage of vaccine (especially for humans). Future efforts and progress in controlling giardiasis are expected in three aspects: clarification of the drug resistance mechanisms, development of efficient vaccines, and identification of more targets for new drugs and vaccines.
Tian
Hai-Feng
HF
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS), Kunming, Yunnan Province 650223, China.
Chen
Bing
B
Wen
Jian-Fan
JF
D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D055808:Drug Discovery; D004351:Drug Resistance; D016829:Giardia lamblia / Q000187:drug effects / Q000378:metabolism; D005873:Giardiasis / Q000188:drug therapy* / Q000469:parasitology / Q000517:prevention & control; D006801:Humans; D016052:Protozoan Vaccines / Q000494:pharmacology
D000981:Antiprotozoal Agents; D016052:Protozoan Vaccines