[Solid malignancy in patients who received cyclosporine for fibrosing interstitial pneumonia].
OBJECTIVE
Since more solid malignancies are observed in transplant recipients treated with cyclosporine (CsA) than in healthy persons. We sought to describe the incidence of malignancy in patients treated with CsA for fibrosing interstitial pneumonia.


METHODS
We prospectively reviewed 43 patients who received CsA and prednisolone for fibrosing interstitial pneumonia over 180 days at our hospital between April 2004 and October 2008. The duration of CsA treatment was 632 +/- 364 days.


RESULTS
Malignancy developed in 6 (14.0%) patients. Time to diagnosis after medical intervention ranged from 394 days to 1325 days (mean, 783 days). Non-small cell lung cancer was diagnosed in 4 cases. These were discovered by routine computed tomography in all cases. Hepatocellular carcinoma and gastric cancer were each diagnosed in 1 case, respectively. Incidence of malignancy tended to be higher in patients who had been treated with CsA for 567 days or more than in those who had been treated for less than 567 days, but this was not statistically significant.


CONCLUSIONS
Our results highlight the need for close follow-up for patients who receive CsA for over 2 years. This could lead to cancer detection at an early stage.
Kawamura
Kodai
K
Division of Respiratory Medicine, Saiseikai Kumamoto Hospital.
Ichikado
Kazuya
K
Muranaka
Hiroyuki
H
Gushima
Yasuhiro
Y
Iwamoto
Norihiro
N
Takaki
Makoto
M
Kuda
Tomoya
T
Honda
Mitsuko
M
Arakawa
Naoko
N
Suga
Moritaka
M
D000368:Aged; D065095:Calcineurin Inhibitors; D015331:Cohort Studies; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000737:chemistry*; D011446:Prospective Studies; D013256:Steroids / Q000008:administration & dosage
D065095:Calcineurin Inhibitors; D013256:Steroids; D016572:Cyclosporine