Synthesis and biological evaluation of new 5-fluorouracil-substituted ampelopsin derivatives.
This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, 1H-NMR, 13C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using the MTT assay, and the results showed that the two new compounds were more effective than reference drugs such as ampelopsin and verapamil.
Zhou
Wei-Ming
WM
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, China. weiming81@126.com
He
Rong-Rong
RR
Ye
Jian-Tao
JT
Zhang
Na
N
Liu
De-Yu
DY
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D044950:Flavanones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans
C551078:2-(4-(2-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)acetoxy)-3,5-dihydroxyphenyl)-5,7-dihydroxy-4-oxochroman-3-yl-2-(5-fluoro-2-dihydropyrimidin-1(2H)-yl)acetate; C551077:5,7-dihydroxy-4-oxo-2-(3,4,5-trihydroxyphenyl)chroman-3-yl-2-(5-fluoro-2,4-dioxo-3,4-dihydroxypyrimidin-1(2H)-yl)acetate; D000970:Antineoplastic Agents; D044950:Flavanones; D005419:Flavonoids; C106407:ampelopsin; D005472:Fluorouracil