title: Neuroprotective effects of ethyl-eicosapentaenoic acid in first episode psychosis: a longitudinal T2 relaxometry pilot study.
abstract: We used magnetic resonance imaging to examine the effect of ethyl-eicosapentaenoic acid (E-EPA) on hippocampal T(2) relaxation time in first episode psychosis patients at baseline and after 12 weeks of follow-up. There was an increase in T(2) in the placebo group but not in the E-EPA group, suggesting a neuroprotective effect of E-EPA treatment. In addition, the smaller the increase in T(2), the greater the improvement in negative symptoms.
authors.affiliation: Melbourne Neuropsychiatry Centre, University of Melbourne, Australia. sjwood@unimelb.edu.au
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Wood
authors.forename: Luca
authors.initials: L
authors.lastname: Cocchi
authors.forename: Tina-Marie
authors.initials: TM
authors.lastname: Proffitt
authors.forename: Mirabel
authors.initials: M
authors.lastname: McConchie
authors.forename: Graeme D
authors.initials: GD
authors.lastname: Jackson
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Takahashi
authors.forename: Christos
authors.initials: C
authors.lastname: Pantelis
authors.forename: Patrick D
authors.initials: PD
authors.lastname: McGorry
authors.forename: Gregor E
authors.initials: GE
authors.lastname: Berger
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D004311:Double-Blind Method; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006624:Hippocampus / Q000187:drug effects; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D010865:Pilot Projects; D011618:Psychotic Disorders / Q000188:drug therapy* / Q000473:pathology; D013223:Statistics as Topic; D055815:Young Adult
chemical_list: D018696:Neuroprotective Agents; C035276:eicosapentaenoic acid ethyl ester; D015118:Eicosapentaenoic Acid