MicroRNAs as new players in the genomic galaxy and disease puzzles.
Abstract MicroRNAs (miRNAs) are a large family of short, single-stranded, highly conserved noncoding RNAs involved in gene regulation that can regulate gene expression through sequence-specific base pairing with target messenger RNAs (mRNAs). miRNAs have been implicated in the development of a wide variety of cancers as well as heart disease and other diseases. This review describes the role of miRNAs in human disease, methodology for evaluating miRNA gene expression, and the potential role of miRNAs as therapeutic agents and targets for the treatment of disease.
Barbarotto
Elisa
E
Department of Morphology and Embryology, University of Ferrara, Ferrera, Italy.
Secchiero
Paola
P
Dasgupta
Abhijit
A
Fortina
Paolo
P
Calin
George A
GA
Hyslop
Terry
T
D000818:Animals; D017173:Caenorhabditis elegans; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D015972:Gene Expression Regulation, Neoplastic; D023281:Genomics / Q000379:methods*; D006331:Heart Diseases / Q000378:metabolism*; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D008954:Models, Biological; D009369:Neoplasms / Q000378:metabolism*; D014018:Tissue Distribution
D035683:MicroRNAs