FOXO1, T-cell trafficking and immune responses.
Efficient T-cell adaptive immune response require a faultless coordination between migration of naive T-cells into secondary lymphoid organs and critical biological outcomes driven by antigen such as cell division and cell differentiation into effector and memory cells. Recent works have shown that the phosphoinositide 3-kinase (PI3K) pathway could govern several of these processes. In this control, transcriptional factors of the Forkhead box O (FoxO) family, in particular FOXO1, a downstream effector of PI3K, appears to play a major role by coordinating both cellular proliferation of T-cells after antigen recognition and expression of homing molecules essential for their trafficking in the body.
Carrette
Florent
F
Institut Cochin, Université Paris Descartes, Centre National de la Recherche Scientifique, Equipe Labellisée par la Ligue Nationale Contre le Cancer, France.
Fabre
Stéphanie
S
Bismuth
Georges
G
D002465:Cell Movement; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors / Q000502:physiology*; D006801:Humans; D055633:Immune System Phenomena; D013601:T-Lymphocytes / Q000276:immunology*
C085126:FOXO1 protein, human; D000071161:Forkhead Box Protein O1; D051858:Forkhead Transcription Factors