Discovery of veterinary antiparasitic agents in the 21st century: a view from industry.
Discovery of antiparasitic agents is a challenging process, requiring discovery of molecules with the ability to kill parasites but not their hosts. Customer preference is for fewer doses and ease of application, but this is not always compatible with reduced withdrawal times, human food safety and/or user safety. This article describes some of the difficulties faced by researchers in the search for new antiparasitic agents, while highlighting advances that may improve the discovery process and the chance of success in discovering novel drugs.
Woods
Debra J
DJ
Veterinary Medicine Research and Development, Pfizer Animal Health, 7000 Portage Road, Kalamazoo, MI 49001, USA. debra.j.woods@pfizer.com
Knauer
Christopher S
CS
D000818:Animals; D016503:Drug Delivery Systems; D015195:Drug Design; D055808:Drug Discovery; D004345:Drug Industry / Q000266:history; D049673:History, 20th Century; D049674:History, 21st Century; D058751:Livestock; D010273:Parasitic Diseases, Animal / Q000188:drug therapy*; D057805:Pets; D012106:Research; D019155:Veterinary Drugs / Q000494:pharmacology*
D019155:Veterinary Drugs