Secondary hypertension due to a renin-secreting juxtaglomerular cell tumor.
A juxtaglomerular cell tumor (JCT) is a rare, renin-secreting tumor of the kidney and can cause hypertension. JCT is pathologically benign, and resection of the tumor is curative for hypertension. We report the case of a 17-year-old girl who had hypertension and hypokalemia for 1 year. Laboratory studies showed increased basal plasma renin activity, but normal serum aldosterone level. Abdominal computed tomography disclosed a 2 cm solid mass in the left kidney. However, renal vein sampling and captopril test results were equivocal. Partial nephrectomy was performed and histologic examination demonstrated typical features of JCT. Hypertension and hypokalemia completely resolved postoperatively. JCT should be considered when investigating hypertensive individuals with high plasma renin activity.
Lin
Shih-Yi
SY
Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan.
Liu
Wayne-Young
WY
Chen
Wen-Chi
WC
Chen
Rong-Hsing
RH
D000230:Adenocarcinoma / Q000150:complications / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000293:Adolescent; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007008:Hypokalemia / Q000209:etiology; D007606:Juxtaglomerular Apparatus / Q000473:pathology; D007680:Kidney Neoplasms / Q000150:complications / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D009392:Nephrectomy; D012083:Renin / Q000378:metabolism*; D016896:Treatment Outcome
D012083:Renin