title: Intracerebral hemorrhage secondary to thrombocytopenia in a patient treated with temozolomide.
abstract: Thrombocytopenia related intracerebral hemorrhage (ICH) secondary to chemotherapy induced myelosuppression can be very difficult to manage and may result in the death of the patient. We present the case of a 26-year-old male suffering a fatal ICH in the context of treatment of a high grade glioma with temozolomide. The clinician should be aware that a dose dependent severe and possible irreversible myelotoxicity can occur with temozolomide treatment resulting in substantial morbidity.
authors.forename: Durga
authors.initials: D
authors.lastname: Sure
authors.forename: Ian
authors.initials: I
authors.lastname: Dunn
authors.forename: Andrew
authors.initials: A
authors.lastname: Norden
authors.forename: William S
authors.initials: WS
authors.lastname: Anderson
mesh_terms: D000328:Adult; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D002543:Cerebral Hemorrhage / Q000209:etiology*; D003606:Dacarbazine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D017809:Fatal Outcome; D005910:Glioma / Q000150:complications / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D008297:Male; D012008:Recurrence; D000077204:Temozolomide; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000150:complications
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide