title: Periradicular regeneration after endodontic surgery with calcium-enriched mixture cement in dogs.
abstract: BACKGROUND
  The aim of this in vivo study was to compare the response of periradicular tissues to mineral trioxide aggregate (MTA) and calcium-enriched mixture (CEM) cement as root-end fillings and to analyze hard tissue healing after periradicular surgery.
  
  
  METHODS
  Intentional periradicular lesions were induced in 32 premolar teeth in 4 beagle dogs. The root canals were prepared, dried, and obturated with laterally condensed gutta-percha with sealer, and the coronal access cavities were filled with amalgam. After surgical exposure of the apices, 2-3 mm of the apical root was resected, and root-end cavities were ultrasonically prepared. The root-end cavities were randomly filled with MTA or CEM cement. After 2 months, the animals were killed; tissue blocks were removed and prepared for histologic examination. Hard tissue healing including cementum and new bone formation in addition to concentration and extent of inflammation were evaluated.
  
  
  RESULTS
  Eight samples were excluded. The major finding was the cementum deposition adjacent to MTA in 11 of 12 samples and CEM cement in 10 of 12 samples. With one-way analysis of variance, no significant difference was observed between the periradicular tissue response to tested materials.
  
  
  CONCLUSIONS
  CEM cement and MTA were associated with regenerative periapical tissue response when used as root-end filling biomaterials.
authors.affiliation: Iranian Center for Endodontic Research, Dental Research Center, School of Dentistry, Shahid Beheshti Medical University, Tehran, Iran. saasgary@yahoo.com
authors.forename: Saeed
authors.initials: S
authors.lastname: Asgary
authors.forename: Mohammad Jafar
authors.initials: MJ
authors.lastname: Eghbal
authors.forename: Sara
authors.initials: S
authors.lastname: Ehsani
mesh_terms: D017607:Aluminum Compounds / Q000494:pharmacology / Q000627:therapeutic use; D016301:Alveolar Bone Loss / Q000188:drug therapy*; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology; D017610:Calcium Compounds / Q000494:pharmacology / Q000627:therapeutic use; D025021:Cementogenesis / Q000187:drug effects*; D003738:Dental Cements / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D004285:Dogs; D004338:Drug Combinations; D008297:Male; D010087:Oxides / Q000494:pharmacology / Q000627:therapeutic use; D010485:Periapical Periodontitis / Q000188:drug therapy*; D011446:Prospective Studies; D011897:Random Allocation; D012038:Regeneration / Q000187:drug effects*; D012184:Retrograde Obturation; D012387:Root Canal Filling Materials / Q000494:pharmacology / Q000627:therapeutic use*; D017640:Silicates / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D003738:Dental Cements; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate; D002118:Calcium