title: p-Aminoacetophenonic acids produced by a mangrove endophyte Streptomyces sp. (strain HK10552).
abstract: Four new p-aminoacetophenonic acids, named (2E)-11-(4'-aminophenyl)-5,9-dihydroxy-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (1), 9-(4'-aminophenyl)-3,7-dihydroxy-2,4,6-trimethyl-9-oxo-nonoic acid(2), (2E)-11-(4'-aminophenyl)-5,9-O-cyclo-4,6,8-trimethyl-11-oxo-undec-2-enoic acid (3) and 9-(4'-aminophenyl)-3,7-O-cyclo-2,4,6-trimethyl-9-oxo-nonoic acid(4), were isolated from an endophyte Streptomyces sp. (strain HK10552) of the mangrove plant Aegiceras corniculatum. The structures of 1-4 were elucidated by using spectroscopic analyses. The relative stereoconfigurations of compounds 3 and 4 were determined by NOESY experiments. In the bioassay test, 1-4 showed no cytotoxicity against the Hela cell lines. Compound 4 also showed no inhibitory bioactivity on HCV protease and SecA ATPase and wasn't active against VSVG/HIV-luc pseudotyping virus.
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing, China. fangfang70303@yahoo.com.cn
authors.forename: Fangfang
authors.initials: F
authors.lastname: Wang
authors.forename: Minjuan
authors.initials: M
authors.lastname: Xu
authors.forename: Qingshan
authors.initials: Q
authors.lastname: Li
authors.forename: Isable
authors.initials: I
authors.lastname: Sattler
authors.forename: Wenhan
authors.initials: W
authors.lastname: Lin
mesh_terms: D000098:Acetophenones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors; D006367:HeLa Cells; D016174:Hepacivirus / Q000201:enzymology; D006801:Humans; D026901:Membrane Transport Proteins; D029623:Primulaceae / Q000382:microbiology*; D011480:Protease Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000069816:SEC Translocation Channels; D000081416:SecA Proteins; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000098:Acetophenones; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001426:Bacterial Proteins; D026901:Membrane Transport Proteins; D011480:Protease Inhibitors; D000069816:SEC Translocation Channels; D000251:Adenosine Triphosphatases; D000081416:SecA Proteins