Ameliorative effect of Emblica officinalis aqueous extract on ochratoxin-induced lipid peroxidation in the kidney and liver of mice.
OBJECTIVE
The present study was an attempt at investigating whether the aqueous extract of Emblica officinalis may have an ameliorative effect on ochratoxin-induced lipid peroxidation in the kidney and liver of mice.


METHODS
Adult male albino mice were orally administered 50 microg (LD, low dose) and 100 microg (HD, high dose) of ochratoxin/0.2 ml of olive oil/animal/day for 45 days.


RESULTS
The results revealed a significant (p < 0.05), dose-dependent increase in lipid peroxidation as well as a decreased activity of enzymatic antioxidants (superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase and glutathione transferase) and non-enzymatic antioxidants (glutathione and total ascorbic acid) in both the organs, as compared to the findings for olive oil-treated control group. Administration of Emblica officinalis aqueous extract (2 mg/animal/day) and ochratoxin for a period of 45 days caused a significant amelioration in the ochratoxin-induced lipid peroxidation in mouse liver and kidney.
Chakraborty
Devjani
D
Toxicology Division, Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad, India. devjani.chakraborty@yahoo.com
Verma
Ramtej
R
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005638:Fruit; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D009793:Ochratoxins / Q000633:toxicity*; D029842:Phyllanthus emblica; D010936:Plant Extracts / Q000627:therapeutic use*
D000975:Antioxidants; D009793:Ochratoxins; D010936:Plant Extracts