The effect of Rexflavone (Sophorae fructus extract) on menopausal symptoms in postmenopausal women: a randomized double-blind placebo controlled clinical trial.
To observe the protective effect of orally administrated Rexflavone (Sophorae fructus extract) for the postmenopausal symptoms, a randomized double-blind placebo controlled clinical trial was designed. Rexflavone significantly improved 11 menopausal symptoms including hot flash, which was evaluated by the modified Kupperman Index (KI), while hormone level and lipid profile were little changed by consumption. Rexflavone group significantly decreased KI score (-14.91 +/- 8.79) compared to placebo group (-11.45 +/- 6.62) as a representative index for improvement of menopausal symptoms (p < 0.05). We found that Rexflavone has no adverse effect to be safe for long term consumption. It was shown that the consumption of Rexflavone possessed beneficial effects on the postmenopausal symptoms in postmenopausal women.
Lee
Jeongrai
J
RexGene Biotech. Co., Ltd. Research and Development of Life Science, Ochang, 368-831, Korea.
Kim
Kuk Whan
KW
Kim
Hyun-Kyu
HK
Chae
Soo-Wan
SW
Jung
Jae-Chul
JC
Kwon
Suk Hyung
SH
Rheu
Chul Hee
CH
D000284:Administration, Oral; D000328:Adult; D000342:Affective Symptoms / Q000097:blood / Q000188:drug therapy; D001007:Anxiety / Q000097:blood / Q000188:drug therapy; D019587:Dietary Supplements; D004311:Double-Blind Method; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005638:Fruit / Q000737:chemistry; D019584:Hot Flashes / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D006987:Hypesthesia / Q000097:blood / Q000188:drug therapy; D008055:Lipids / Q000097:blood; D008875:Middle Aged; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017698:Postmenopause / Q000097:blood / Q000187:drug effects*; D029909:Sophora / Q000737:chemistry*; D016896:Treatment Outcome
D008055:Lipids; D010936:Plant Extracts; C551319:rexflavone; D004958:Estradiol; D005640:Follicle Stimulating Hormone