title: Antioxidant-like effects and protective action of transcranial magnetic stimulation in depression caused by olfactory bulbectomy.
abstract: We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathione (GSH) content and antioxidative enzymes activities. The treatment with TMS reverted towards normality the biomarkers indicative of oxidative stress and apoptosis. In conclusion, our data show that TMS induced a protection against cell and oxidative damage induced by OBX, as well as they support the hypothesis that oxidative stress may play an important role in depression.
authors.affiliation: Departamento Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Córdoba, Córdoba, Spain.
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Tasset
authors.forename: René
authors.initials: R
authors.lastname: Drucker-Colín
authors.forename: José
authors.initials: J
authors.lastname: Peña
authors.forename: Ignacio
authors.initials: I
authors.lastname: Jimena
authors.forename: Pedro
authors.initials: P
authors.lastname: Montilla
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Medina
authors.forename: Isaac
authors.initials: I
authors.lastname: Túnez
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D053148:Caspase 3 / Q000378:metabolism; D003863:Depression / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D005978:Glutathione / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D009830:Olfactory Bulb; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D050781:Transcranial Magnetic Stimulation
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D053148:Caspase 3; D005978:Glutathione