Soluble inflammatory markers as predictors of hepatocellular damage and therapeutic response in chronic hepatitis C.
Hepatitis C is an important burden worldwide being an important cause of cirrhosis and liver cancer in different parts of the world. Host immune response, especially T helper type 1 (Th1) cell-mediated, seems to play an important role in disease progression but is also crucial for viral elimination following specific therapy. Immune activation can be evaluated using peripheral levels of different cytokines, such as different chemokines (e.g. CCL5, CXCL10) and tumor necrosis factor alpha (TNF-alpha), and their soluble receptors (e.g. soluble TNF-alpha receptors 1 (sTNF-R1) and 2 (sTNF-R2). This review article focuses on the potential use of peripheral inflammatory markers as predictors of liver histological changes and therapeutic response among patients with chronic hepatitis C.
Moura
Alexandre Sampaio
AS
Federal University of Minas Gerais, Brazil.
Carmo
Ricardo Andrade
RA
Teixeira
Antonio Lucio
AL
Rocha
Manoel Otávio da Costa
MO
D015415:Biomarkers / Q000097:blood; D018925:Chemokines / Q000097:blood*; D018450:Disease Progression; D019698:Hepatitis C, Chronic / Q000097:blood* / Q000150:complications / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood* / Q000209:etiology / Q000473:pathology; D047888:Receptors, Tumor Necrosis Factor, Type I / Q000097:blood*; D047889:Receptors, Tumor Necrosis Factor, Type II / Q000097:blood*; D018417:Th1 Cells / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
D015415:Biomarkers; D018925:Chemokines; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D014409:Tumor Necrosis Factor-alpha