title: Family history of hypertension as an important risk factor for the development of severe preeclampsia.
abstract: OBJECTIVE
  To determine the risk of preeclampsia in a population with respect to maternal and sister histories of chronic hypertension, preeclampsia and eclampsia.
  
  
  METHODS
  A case-control study of severe preeclampsia.
  
  
  METHODS
  Maternity hospital in Natal, Brazil.
  
  
  METHODS
  A total of 412 subjects were enrolled, 148 cases and 264 controls.
  
  
  METHODS
  Personal and familial histories of hypertensive disorders. Odds ratio estimates of preeclampsia with respect to family history of hypertensive diseases.
  
  
  RESULTS
  Women with a history of hypertensive disorders were more frequent in the case group (p = 0.001). Women whose mothers had a history of hypertension (p = 0.003), preeclampsia (p = 0.007) or eclampsia (p = 0.038) were at increased risk of severe preeclampsia. The risk of preeclampsia was greater when the woman had a sister with a history of hypertension (OR 2.60, 95% CI 1.60-4.21, p < 0.001), preeclampsia (OR 2.33, 95% CI 1.58-3.45, p < 0.001), or eclampsia (OR 2.57, 95% CI 1.28-5.16, p = 0.008). The risk of preeclampsia was also higher for women who had both a mother and sister with a history of hypertension (OR 3.65, 95% CI 1.65-8.09, p = 0.001).
  
  
  CONCLUSIONS
  A family history of hypertensive disorders increased the risk of eclampsia and hemolysis elevated liver enzymes and low platelet (HELLP) syndrome in a Brazilian population.
authors.affiliation: Health Graduate Program, Universidade Federal do Rio Grande do Norte, Natal, RN, Brazil.
authors.forename: Patricia C F M
authors.initials: PC
authors.lastname: Bezerra
authors.forename: Marcos D
authors.initials: MD
authors.lastname: Leão
authors.forename: José W
authors.initials: JW
authors.lastname: Queiroz
authors.forename: Edailna M D
authors.initials: EM
authors.lastname: Melo
authors.forename: Flávio V M
authors.initials: FV
authors.lastname: Pereira
authors.forename: Maria Hebe
authors.initials: MH
authors.lastname: Nóbrega
authors.forename: Ana K
authors.initials: AK
authors.lastname: Jeronimo
authors.forename: Leonardo C
authors.initials: LC
authors.lastname: Ferreira
authors.forename: Selma M B
authors.initials: SM
authors.lastname: Jerônimo
authors.forename: Ana Cristina P F
authors.initials: AC
authors.lastname: de Araújo
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D015984:Causality; D015897:Comorbidity; D016001:Confidence Intervals; D005192:Family Health; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D015994:Incidence; D016017:Odds Ratio; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000235:genetics*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology / Q000235:genetics; D011256:Pregnancy Outcome; D011336:Probability; D012016:Reference Values; D012307:Risk Factors; D012720:Severity of Illness Index; D055815:Young Adult