title: Ichthyosis hystrix Curth-Macklin type in an African girl.
abstract: Ichthyosis hystrix Curth-Macklin type is a rare autosomal dominant skin disorder characterized by extensive hyperkeratosis and palmo-plantar keratoderma. It results from heterozygous frameshift mutation in keratin 1 gene (KRT1). Histological features, showing perinuclear vacuolization and binucleated cells, are similar to those of epidermolytic hyperkeratosis except for the absence of epidermolysis. The present report describes the condition in a 16-year-old African girl where available treatment was disappointing.
authors.affiliation: Dermatology Unit, Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria. shehumy@yahoo.com
authors.forename: S M
authors.initials: SM
authors.lastname: Yusuf
authors.forename: M S
authors.initials: MS
authors.lastname: Mijinyawa
authors.forename: M B
authors.initials: MB
authors.lastname: Maiyaki
authors.forename: A Z
authors.initials: AZ
authors.lastname: Mohammed
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D007057:Ichthyosis / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D015776:Keratoderma, Palmoplantar, Diffuse / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D019656:Loss of Heterozygosity; D017211:Treatment Failure