title: Induction of oxidative stress in the epididymis of rats after subchronic exposure to epichlorohydrin.
abstract: This study investigated the effects of epichlorohydrin (ECH) on spermatogenesis and antioxidant system in rats. An increase in the incidence of clinical signs, gross pathology and histopathology findings in the epididymidis, and sperm abnormalities and a decrease in the testicular spermatid counts, epididymal sperm counts, and sperm motility were observed at 30 mg/kg/day. Oxidative stress in the epididymal tissue was detected at > or =3.3 mg/kg/day. The results show that graded doses of ECH elicit depletion of antioxidant defense system and that the adverse effects on male reproductive function in ECH-treated rats may be due to the induction of oxidative stress.
authors.affiliation: Animal Medical Center, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of Korea.
authors.forename: In-Sik
authors.initials: IS
authors.lastname: Shin
authors.forename: Jeong-Hyeon
authors.initials: JH
authors.lastname: Lim
authors.forename: Sung-Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Kang-Hyeon
authors.initials: KH
authors.lastname: Kim
authors.forename: Na-Hyeong
authors.initials: NH
authors.lastname: Park
authors.forename: Chun-Sik
authors.initials: CS
authors.lastname: Bae
authors.forename: Seong-Soo
authors.initials: SS
authors.lastname: Kang
authors.forename: Changjong
authors.initials: C
authors.lastname: Moon
authors.forename: Sung-Ho
authors.initials: SH
authors.lastname: Kim
authors.forename: Woojin
authors.initials: W
authors.lastname: Jun
authors.forename: Jong-Choon
authors.initials: JC
authors.lastname: Kim
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004785:Environmental Pollutants / Q000633:toxicity*; D004811:Epichlorohydrin / Q000633:toxicity*; D004822:Epididymis / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D036401:Toxicity Tests, Chronic
chemical_list: D000975:Antioxidants; D004785:Environmental Pollutants; D008054:Lipid Peroxides; D004811:Epichlorohydrin; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases