title: Maternal serum triglycerides as predictive factors for large-for-gestational age newborns in women with gestational diabetes mellitus.
abstract: OBJECTIVE
  To determine the contribution of maternal lipids in predicting large-for-gestational age (LGA) newborns born to women with gestational diabetes mellitus (GDM).
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  Yonsei University Health System, Korea.
  
  
  METHODS
  A total of 104 women diagnosed with GDM between January 2000 and June 2008.
  
  
  METHODS
  Women who were positive on the 50 g oral glucose challenge test (24-28 weeks' gestation) and who were referred patients suspected of GDM underwent a 3 hours, 100 g oral glucose tolerance test for GDM diagnosis. Maternal fasting serum triglycerides and total, high-density lipoprotein (HDL), and low-density lipoprotein cholesterol levels were determined at 24-32 weeks' gestation. Logistic regression analysis was performed to determine maternal parameters independently associated with delivering LGA newborns at term.
  
  
  METHODS
  Risk contributions for LGA newborns.
  
  
  RESULTS
  Maternal fasting serum triglyceride levels were significantly higher in mothers of LGA newborns compared with other mothers; however, no significant correlations were found between newborn birthweight and maternal fasting glucose, total cholesterol, or HDL cholesterol levels. After adjusting for confounding variables including prepregnancy body mass index, weight gain during pregnancy, age, and parity, maternal hypertriglyceridemia at 24-32 weeks' gestation remained an independent parameter for identifying term LGA newborns.
  
  
  CONCLUSIONS
  In GDM pregnancies, determining maternal serum triglyceride levels during midpregnancy may help identify women likely to give birth to LGA newborns.
authors.affiliation: Department of Obstetrics and Gynecology, Yonsei University Health System, 134 Shinchon-dong Seodaemun-gu, Seoul, Korea.
authors.forename: Ga Hyun
authors.initials: GH
authors.lastname: Son
authors.forename: Ja Young
authors.initials: JY
authors.lastname: Kwon
authors.forename: Young Han
authors.initials: YH
authors.lastname: Kim
authors.forename: Yong Won
authors.initials: YW
authors.lastname: Park
mesh_terms: D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism; D015331:Cohort Studies; D015897:Comorbidity; D016640:Diabetes, Gestational / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005320:Fetal Macrosomia / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000453:epidemiology*; D005500:Follow-Up Studies; D005865:Gestational Age; D005951:Glucose Tolerance Test; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007333:Insulin Resistance; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011336:Probability; D012189:Retrospective Studies; D018570:Risk Assessment; D014280:Triglycerides / Q000097:blood*; D016216:Ultrasonography, Prenatal
chemical_list: D001786:Blood Glucose; D014280:Triglycerides