Synthesis and antitumor evaluation of a novel class of 4-substituted-1,4-dihydroisoquinolin-3-ones.
An efficient method for the solution-phase parallel synthesis of 4-substituted-1,4-dihydroisoquinolin-3-ones is developed. The isoquinolinones were constructed employing an intramolecular Heck reaction, providing full regio- and stereoselectivity. Most of the synthesized compounds showed potent antiproliferative activities against tumor cell lines.
Ma
Ting
T
Institute of Materia Medica, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China.
Chen
Wenteng
W
Zhang
Guolin
G
Yu
Yongping
Y
D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D054852:Small Molecule Libraries; D013237:Stereoisomerism
D000981:Antiprotozoal Agents; D007546:Isoquinolines; D054852:Small Molecule Libraries