title: Synthesis and antimicrobial activities of some new 1,2,3-triazole derivatives.
abstract: Some novel 4,5-disubstituted-2,4-dihydro-3H-1,2,4-triazol-3-one (3, 6, 8, 9) derivatives and or 3-(4-methylphenyl)[1,2,4]triazolo[3,4-b][1,3]benzoxazole (5) were synthesized from the reaction of various ester ethoxycarbonylhydrazones (1a-e) with several primary amines. The synthesis of 4-amino-5-(4-chlorophenyl)-2-[(5-mercapto-1,3,4-oxadiazol-2-yl)methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (13) was performed starting from 4-Amino-5-(4-chlorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (2) by four steps; then 13 was converted to the corresponding Schiff base (14) by using 4-methoxybenzaldehyde. Finally, two Mannich base derivatives of 14 were obtained by using morpholine or methyl piperazine as amine component. All newly synthesized compounds were screened for their antimicrobial activities and some of which were found to possess good or moderate activities against the test microorganisms.
authors.affiliation: Department of Chemistry, Karadeniz Technical University, Trabzon, Turkey.
authors.forename: Hakan
authors.initials: H
authors.lastname: Bektaş
authors.forename: Nesrin
authors.initials: N
authors.lastname: Karaali
authors.forename: Deniz
authors.initials: D
authors.lastname: Sahin
authors.forename: Ahmet
authors.initials: A
authors.lastname: Demirbaş
authors.forename: Sengül Alpay
authors.initials: SA
authors.lastname: Karaoglu
authors.forename: Neslihan
authors.initials: N
authors.lastname: Demirbaş
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D041022:Candida tropicalis / Q000187:drug effects; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D014230:Triazoles; C045575:1,2,4-triazole