title: Maternal use of bupropion and risk for congenital heart defects.
abstract: OBJECTIVE
  We sought to determine if maternal bupropion treatment in early pregnancy is associated with congenital heart defects in the infant.
  
  
  METHODS
  We conducted a retrospective case-control study of birth defects risk factors. Data on 6853 infants with major heart defects were compared with 5869 control infants born in 1997-2004. Bupropion exposure was defined as any reported use between 1 month before and 3 months after conception.
  
  
  RESULTS
  Mothers of infants with left outflow tract heart defects were more likely to have reported taking bupropion than mothers of control infants (adjusted odds ratio, 2.6; 95% confidence interval, 1.2-5.7; P = .01).
  
  
  CONCLUSIONS
  We identified a positive association between early pregnancy bupropion use and left outflow tract heart defects; however, the magnitude of the observed increased risk was small. Nevertheless, further studies are needed to confirm these results.
authors.affiliation: Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Sura
authors.initials: S
authors.lastname: Alwan
authors.forename: Jennita
authors.initials: J
authors.lastname: Reefhuis
authors.forename: Lorenzo D
authors.initials: LD
authors.lastname: Botto
authors.forename: Sonja A
authors.initials: SA
authors.lastname: Rasmussen
authors.forename: Adolfo
authors.initials: A
authors.lastname: Correa
authors.forename: Jan M
authors.initials: JM
authors.lastname: Friedman
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000627:therapeutic use; D016642:Bupropion / Q000009:adverse effects* / Q000627:therapeutic use; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006330:Heart Defects, Congenital / Q000139:chemically induced*; D006801:Humans; D007231:Infant, Newborn; D007407:Interviews as Topic; D018811:Maternal Exposure / Q000009:adverse effects*; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D018687:Antidepressive Agents, Second-Generation; D016642:Bupropion