title: Association of plasma selenium concentrations with total IGF-1 among older community-dwelling adults: the InCHIANTI study.
abstract: OBJECTIVE
  Insulin-like growth factor (IGF-1) stimulates cell proliferation and inhibits cell apoptosis. Recent studies underline its importance as anabolic hormone and nutritional marker in older individuals. IGF-1 synthesis and bioactivity are modulated by nutritional factors including selenium intake. However, whether circulating IGF-1 levels are positively influenced by plasma selenium, one of the most important human antioxidants, is still unknown.
  
  
  METHODS
  Selenium and total IGF-1 were measured in 951 men and women ≥ 65 years from the InCHIANTI study, Tuscany, Italy.
  
  
  RESULTS
  Means (SD) of plasma selenium and total IGF-1 were 0.95 (0.15) μmol/L and 113.4 (31.2)ng/mL, respectively. After adjustment for age and sex, selenium levels were positively associated with total IGF-1 (β±SE: 43.76±11.2, p=0.0001). After further adjustment for total energy and alcohol intake, serum alanine aminotransferase (ALT), congestive heart failure, selenium remained significantly associated with IGF-1 (β±SE: 36.7±12.2, p=0.003). The association was still significant when IL-6 was introduced in the model (β±SE: 40.1±12.0, p=0.0008).
  
  
  CONCLUSIONS
  We found an independent, positive and significant association between selenium and IGF-1 serum levels in community dwelling older adults.
authors.affiliation: Department of Internal Medicine and Biomedical Sciences, Section of Geriatrics, University of Parma, Parma, Italy. marcellomaggio2001@yahoo.it
authors.forename: Marcello
authors.initials: M
authors.lastname: Maggio
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Ceda
authors.forename: Fulvio
authors.initials: F
authors.lastname: Lauretani
authors.forename: Stefania
authors.initials: S
authors.lastname: Bandinelli
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Dall'Aglio
authors.forename: Jack M
authors.initials: JM
authors.lastname: Guralnik
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Paolisso
authors.forename: Richard D
authors.initials: RD
authors.lastname: Semba
authors.forename: Antonio
authors.initials: A
authors.lastname: Nouvenne
authors.forename: Loris
authors.initials: L
authors.lastname: Borghi
authors.forename: Graziano
authors.initials: G
authors.lastname: Ceresini
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Ablondi
authors.forename: Mario
authors.initials: M
authors.lastname: Benatti
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D003430:Cross-Sectional Studies; D002149:Energy Intake; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007558:Italy; D008297:Male; D012111:Residence Characteristics; D012643:Selenium / Q000097:blood* / Q000378:metabolism
chemical_list: D007334:Insulin-Like Growth Factor I; D012643:Selenium