title: GC-MS analysis, antibacterial activity and genotoxic property of Erigeron mucronatus essential oil.
abstract: GC-MS analysis of the hydrodistilled oil of Erigeron mucronatus DC was carried out, after the separation of a crystalline compound, lachnophyllum cumulene. Twenty-four components were identified. The oil contained 59.6% sesquiterpenoids, 16.1% monoterpenoids and 24.3% poly-acetylenic esters. Among the mono and sesquiterpenoids, limonene (10.3%) and caryophyllenes (11.4%) were the major constituents. The essential oil also revealed the unusual presence of both cis (8.3%) and trans (1.1%) methyl lachnophyllum esters. Seasonal variation in the yield of E. mucronatus oil was observed. The yield varied from 0.49 to 0.58%, being highest during the rainy season. Antimicrobial activity was assessed using a method based on zones of inhibition; the oil exhibited maximum anti- bacterial activity against both Staphylococcus aureus and Escherichia coli, but moderate activity against Pseudomonas aeruginosa. Genotoxicity of the oil was determined in AB blood serum at different concentrations and hours of exposure. The antibacterial activity of the oil and its insignificant genotoxicity at low concentrations make the oil a good candidate as a curative agent.
authors.affiliation: Department of Medicinal Pharmacognosy, Faculty of Pharmacy, Seventh of April University, Libya.
authors.forename: Bahlul Z
authors.initials: BZ
authors.lastname: Awen
authors.forename: C Ramachandra
authors.initials: CR
authors.lastname: Unnithan
authors.forename: Subban
authors.initials: S
authors.lastname: Ravi
authors.forename: Akoni J
authors.initials: AJ
authors.lastname: Lakshmanan
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D049919:Erigeron / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008800:Mexico; D008826:Microbial Sensitivity Tests; D009152:Mutagenicity Tests; D009822:Oils, Volatile / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D009822:Oils, Volatile; D010938:Plant Oils; D013729:Terpenes