title: Clopidogrel treatment in a patient with ticlopidine-induced hepatitis following percutaneous coronary stenting.
abstract: Thienopyridines are commonly prescribed antiplatelets drugs, extremely useful for the acute and chronic management of patients with cerebrovascular and cardiovascular diseases. The occurrence of their side effects is fortunately uncommon, although unpredictable. We thereby describe a case of prescription of clopidogrel in a patient with ticlopidine-induced hepatitis confirmed by liver biopsy that had undergone multiple percutaneous coronary stenting procedures necessitating subsequent compulsory antiplatelets treatment. The description of this exceptional clinical case is of relevant knowledge to orientate a physician treating a patient with absolute need of antiplatelets and history of previous drug-induced reactions.
authors.affiliation: Cardiology Division, Department of Medicine, University of Turin, San Giovanni Battista Hospital, Turin, Italy. matt.ans@alice.it
authors.forename: M
authors.initials: M
authors.lastname: Anselmino
authors.forename: C
authors.initials: C
authors.lastname: Moretti
authors.forename: L
authors.initials: L
authors.lastname: Ravera
authors.forename: I
authors.initials: I
authors.lastname: Sheiban
mesh_terms: D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D000077144:Clopidogrel; D005260:Female; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D011183:Postoperative Complications / Q000139:chemically induced*; D015607:Stents; D013988:Ticlopidine / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D000077144:Clopidogrel; D013988:Ticlopidine