IL-1 and Allergy.
IL-1 is a well-characterized proinflammatory cytokine that is involved in host defense and autoimmune diseases. IL-1 can promote activation of T cells, including Th1 cells, Th2 cells and Th17 cells, and B cells, suggesting that IL-1 may contribute to the development of various types of T-cell-mediated diseases. This report reviews and discusses the role of IL-1 in the pathogenesis of allergic diseases based on studies using IL-1-related gene-deficient mice.
Nambu
Aya
A
Atopy Research Center, Juntendo University, Tokyo, Japan.
Nakae
Susumu
S
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D007375:Interleukin-1 / Q000235:genetics / Q000276:immunology*; D008213:Lymphocyte Activation / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors; D013601:T-Lymphocytes / Q000276:immunology*
D018926:Anti-Allergic Agents; D007375:Interleukin-1; D017472:Receptors, Interleukin-1