The MPO -463G>A polymorphism and cancer risk: a meta-analysis based on 43 case-control studies.
Myeloperoxidase (MPO) is an endogenous oxidant enzyme that generates reactive oxygen species and plays an important role in the aetiology of cancer. The MPO -463G>A polymorphism influences MPO transcription and has been implicated in cancer risk. However, results from published studies on the association between the MPO -463G>A polymorphism and risk of cancer are conflicting. To derive a more precise estimation of association between the MPO -463G>A polymorphism and risk of cancer, we performed a meta-analysis based on 43 case-control studies, including a total of 14 171 cancer cases and 17 319 controls. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association. Overall, individuals with the -463A allele had a 0.93-fold lower cancer risk in a dominant model (OR = 0.93, 95% CI = 0.87-1.00). In the stratified analyses, we observed a similar association in European populations (heterozygote comparison: OR = 0.90, 95% CI = 0.82-0.99) and hospital-based studies (dominant model: OR = 0.88, 95% CI = 0.79-0.99). When stratified by cancer type, however, no significant association was found. The results suggested that the MPO -463A allele does not contribute to the development of cancer. Additional well-designed large studies are required to validate these findings in different populations.
Chu
Haiyan
H
Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China.
Wang
Meilin
M
Wang
Miaomiao
M
Gu
Dongying
D
Wu
Dongmei
D
Zhang
Zhizhong
Z
Tang
Jialin
J
Zhang
Zhengdong
Z
D016022:Case-Control Studies; D016001:Confidence Intervals; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D016017:Odds Ratio; D009195:Peroxidase / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
D009195:Peroxidase