title: [Bronchiolitis with IgG4-positive plasma cell infiltration in a patient with bronchial asthma].
abstract: A 49-year-old-man was admitted to our hospital because of cough, wheezing, and dyspnea. Chest CT showed bilateral bronchocentric nodules and increased bronchial thickness. And he was given a diagnosis of bronchial asthma. However, another small airway disease, such as diffuse panbronchiolitis (DPB) was also suspected, and surgical lung biopsy was performed. The biopsy specimens showed a prominent peribronchial lymphoplasmacytic and eosinophilic infiltration with IgG4-positive plasma cells. IgG4-positive plasma cells may play a role in the pathogenesis of bronchiolar diseases associated with allergic airway inflammation.
authors.affiliation: Department of Respiratory Medicine, Hamamatsu University School of Medicine.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Masato
authors.initials: M
authors.lastname: Kono
authors.forename: Taisuke
authors.initials: T
authors.lastname: Akamatsu
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kaida
authors.forename: Naoki
authors.initials: N
authors.lastname: Inui
authors.forename: Takafumi
authors.initials: T
authors.lastname: Suda
authors.forename: Kingo
authors.initials: K
authors.lastname: Chida
mesh_terms: D001249:Asthma / Q000150:complications*; D001988:Bronchiolitis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008875:Middle Aged; D010950:Plasma Cells / Q000276:immunology / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G