Studies on development of controlled delivery of combination drug(s) to periodontal pocket.
OBJECTIVE
The aim of this study to develop the controlled delivery of combination drug(s) to periodontal pocket.


METHODS
In the present investigation mucoadhesive gel formulations were prepared using carboxy methylcellulose (CMC), methylcellulose (MC), hydroxyethylcellulose (HEC), polyvinylpirrolidone (PVP), polycarbophil (PC), and poloxamer. Each formulation was characterized in terms of polarizing light microscopy, gelation, gel melting, hardness, compressibility, adhesiveness, cohesiveness, syringeability, adhesion to a mucin disk, rheological studies, drug release, and antibacterial activities. Addition of CMC and PVP to the gel favored hexagonal phase formation. The gelation temperature was decreased linearly with an increasing concentration of drug(s), whereas, the melting temperature increased with the concentration of drug(s). Increasing the concentrations of each polymeric component significantly increased formulation hardness, compressibility, adhesiveness, mucoadhesion, and syringeability, yet a decreased cohesiveness. Increased time of contact between the formulation and mucin significantly increased the required force of detachment. Drug release from all formulations was non-diffusion controlled and significantly decreased as the concentration of the polymer was increased, due to the concomitant increased viscosity of the formulations and the swelling kinetics of PC, following contact with the dissolution fluid.


RESULTS
Antibacterial studies revealed that a gel with 30% HEC had a growth inhibition zone on agar with all three strains.


CONCLUSIONS
Formulations containing HEC exhibited superior physical characteristics for improved drug delivery to the periodontal pocket and are now the subject of long-term clinical investigations.
Tiwari
Gaurav
G
Department of Pharmaceuticals, Jaipur National University, Jagatpura, Jaipur, Rajasthan, India.
Tiwari
Ruchi
R
Rai
Awani K
AK
D000268:Adhesiveness; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D001696:Biomechanical Phenomena; D019245:Compressive Strength; D003692:Delayed-Action Preparations / Q000008:administration & dosage; D003799:Dental Stress Analysis; D004318:Doxycycline / Q000008:administration & dosage*; D004338:Drug Combinations; D015195:Drug Design; D004926:Escherichia coli / Q000187:drug effects; D005782:Gels / Q000737:chemistry; D006244:Hardness; D008422:Materials Testing; D008795:Metronidazole / Q000008:administration & dosage*; D008826:Microbial Sensitivity Tests; D010514:Periodontal Pocket / Q000188:drug therapy*; D016966:Porphyromonas gingivalis / Q000187:drug effects; D012212:Rheology; D013211:Staphylococcus aureus / Q000187:drug effects
D000891:Anti-Infective Agents, Local; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D005782:Gels; D008795:Metronidazole; D004318:Doxycycline