Detection of novel Human papilloma virus type 82 in laryngeal cancer: case report.
Human papilloma virus infection is thought to play a role in laryngeal carcinogenesis; the variable association reported in literature may be due to wide range of HPV genotypes. We report the case of a 51-year-old man affected by laryngeal squamous cell carcinoma; analysis of DNA extracted by cancer cells by an innovative molecular virology assay (INNO-LiPA HPV Genotyping Extra) showed the presence of two high-risk HPV genotypes, HPV-73 and -82. Immunohistochemical examination confirmed positivity for both capsid protein and viral oncogenic protein E7. Such association has never been reported in literature so far, and a brief discussion on the importance of assessing HPV status in laryngeal cancer is provided.
Pannone
G
G
Department of Surgical Sciences, Institute of Pathology and Cytopathology, University of Foggia, Viale Pinto, Foggia, Italy.
Sanguedolce
F
F
Santoro
A
A
Fierro
P
P
Panetti
M
M
Fierro
D
D
Maiello
F
F
De Maria
S
S
Giannattasio
A
A
Serpico
R
R
Lo Muzio
L
L
Metafora
S
S
Bufo
P
P
D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000821:virology*; D015344:DNA Probes, HPV; D005838:Genotype; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000821:virology*; D007825:Laryngectomy; D007830:Larynx / Q000473:pathology / Q000821:virology; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009367:Neoplasm Staging; D027383:Papillomaviridae / Q000145:classification* / Q000235:genetics; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000473:pathology / Q000601:surgery / Q000821:virology*; D014057:Tomography, X-Ray Computed
D015344:DNA Probes, HPV