title: Survival of breast cancer patients with meningeal carcinomatosis.
abstract: BACKGROUND
  Breast cancer is the leading nonhematologic cause of meningeal carcinomatosis (MC). The aim of this study was to report the outcome of patients diagnosed with breast cancer MC and treated in single institution by a high-dose intrathecal methotrexate (MTX) regimen.
  
  
  METHODS
  Ninety-one patients were diagnosed with breast cancer MC from 2000 to 2007. Intrathecal treatment was MTX 15 mg/day (days 1-5), hydrocortisone acetate (day 1) and oral folinic acid (days 1-5), repeated every 2 weeks. Patients and tumor characteristics were associated with the early clinical and biological outcome and with the overall survival (OS).
  
  
  RESULTS
  The median survival was 4.5 months (range 0-53). In multivariate analysis, adverse prognostic factors at diagnosis were performance status >2 [P = 0.006, response rate (RR) = 0.33 (0.15-0.71)], more than three chemotherapy regimens before MC diagnosis [P = 0.03, RR = 0.40 (0.19-0.93)], negative hormone receptor status [P = 0.02, RR = 0.4 (0.19-0.90)] and high Cyfra 21-1 level [P = 0.048, RR = (0.09-0.99)]. Clinical progression after one cycle and biological response after two cycles were independently associated with OS [P < 0.001, RR = 0.09 (0.02-0.37) and P = 0.003, RR = 3.6 (1.5-8.5), respectively]. We propose a prognostic score in order to define three distinct groups of prognosis.
  
  
  CONCLUSIONS
  MC presents a poor prognosis, but 1-year survival rate was 25%. This score may become a useful tool for treatment decision and clinical trials.
authors.affiliation: Department of Medical Oncology, Institut Curie, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Gauthier
authors.affiliation: Department of Medical Oncology, Institut Curie, Paris, France.
authors.forename: M N
authors.initials: MN
authors.lastname: Guilhaume
authors.affiliation: Department of Medical Oncology, Institut Curie, Paris, France.
authors.forename: F C
authors.initials: FC
authors.lastname: Bidard
authors.affiliation: Department of Medical Oncology, Institut Curie, Paris, France; University Paris Descartes, Paris.
authors.forename: J Y
authors.initials: JY
authors.lastname: Pierga
authors.affiliation: Department of Medical Oncology, Institut Curie, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Girre
authors.affiliation: Department of Medical Oncology, Institut Curie, Paris, France.
authors.forename: P H
authors.initials: PH
authors.lastname: Cottu
authors.affiliation: Department of Medical Oncology, Institut Curie, Paris, France.
authors.forename: V
authors.initials: V
authors.lastname: Laurence
authors.affiliation: Department of Medical Oncology, Institut Curie, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Livartowski
authors.affiliation: Department of Medical Oncology, Institut Curie, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Mignot
authors.affiliation: Department of Medical Oncology, Institut Curie, Paris, France. Electronic address: veronique.dieras@curie.net.
authors.forename: V
authors.initials: V
authors.lastname: Diéras
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy / Q000401:mortality*; D018270:Carcinoma, Ductal, Breast / Q000150:complications / Q000188:drug therapy / Q000401:mortality*; D018275:Carcinoma, Lobular / Q000150:complications / Q000188:drug therapy / Q000401:mortality*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D002955:Leucovorin / Q000627:therapeutic use; D055756:Meningeal Carcinomatosis / Q000188:drug therapy / Q000209:etiology*; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D014803:Vitamin B Complex / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D000964:Antimetabolites, Antineoplastic; D014803:Vitamin B Complex; D002955:Leucovorin; D006854:Hydrocortisone; D008727:Methotrexate