title: Defining the components of the research pipeline.
abstract: The National Institutes of Health (NIH) has proposed that research moves from "bench to bedside" through a Pipeline consisting of distinct research categories bridged by bidirectional translation. The original NIH Pipeline has now been expanded to include practice- and community-based research. We developed operational definitions for the elements along the expanded NIH Pipeline. The proposed definitions were pilot-tested and refined using the Computer Retrieval of Information on Scientific Projects (CRISP) and the Secure Internet-Linked Web Technologies (SILK) database containing funding information for individual NIH awards. Using our definitions, two reviewers independently agreed on the categorization of 94% of 866 National Heart, Lung, and Blood Institute (NHLBI)-funded projects, and 99% of projects could be placed into a single research category.
authors.affiliation: College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. james-mold@ouhsc.edu
authors.forename: Michael S
authors.initials: MS
authors.lastname: Kleinman
authors.forename: James W
authors.initials: JW
authors.lastname: Mold
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D016208:Databases, Factual; D005380:Financing, Government; D006801:Humans; D009316:National Institutes of Health (U.S.); D012107:Research Design; D012109:Research Support as Topic; D057170:Translational Research, Biomedical; D014481:United States