title: Hypoglycemic effect of aqueous extract of Trichosanthes dioica in normal and diabetic rats.
abstract: BACKGROUND
  Trichosanthes dioica is used to treat diabetes mellitus, epilepsy, alopecia, and skin disease in folklore medicine. The leaf extract of the plant is used in diabetes mellitus but there have been no scientific studies reported.
  
  
  OBJECTIVE
  To study the effect of Trichosanthes dioica on serum glucose level in glucose loaded, normal and hyperglycemic rats.
  
  
  METHODS
  Kasturba Medical College, Manipal, Karnataka, India.
  
  
  METHODS
  Experimental.
  
  
  METHODS
  The aqueous extract of leaves of Trichosanthes dioica are compared with glibeclamide for their influence on fasting blood sugar in glucose loaded, normoglycemic and streptozotocin induced (45 mg/kg ip) hyperglycemic rats.
  
  
  METHODS
  The data was analyzed by one way ANOVA followed by Scheffe's post hoc test.
  
  
  RESULTS
  In glucose loaded rats, normal rats and hyperglycemic rats the aqueous extract at both the doses (800 mg/kg/p.o and 1600 mg/kg/p.o) reduced blood glucose significantly when compared to control but it was not as effective as glibenclamide.
  
  
  CONCLUSIONS
  The aqueous extract of Trichosanthes dioica has antihyperglycemic action.
authors.affiliation: Department of Pharmacology, Kasturba Medical College, Manipal - 576 104, India.
authors.forename: Shalini
authors.initials: S
authors.lastname: Adiga
authors.forename: K L
authors.initials: KL
authors.lastname: Bairy
authors.forename: A
authors.initials: A
authors.lastname: Meharban
authors.forename: I S R
authors.initials: IS
authors.lastname: Punita