[Prediction of absorption of 10-hydroxycamptothecin in small intestines of rats with its partition coefficients in phases of liposomes and water].
This paper explore the possibility of using the partition of 10-hydroxycamptothecin in the phases of liposome and water to predict the absorption of the drug in small intestine of rats. In order to certify this theory, the in vivo absorption model have been used to study the absorption of 10-hydroxycamptothecin in the small intestine of rats while altering the pH of the medium. The correlation has been explored between the partition of drug in the phases of liposome and water and the absorption of drug in the small intestines of rats. And it was found that the partition of 10-hydroxycamptothecin in the phases of liposome and water and the absorption of the drug in small intestines of rats altered with the changes of pH, and there existed a good relative coefficient between them. All of these indicated that partition of 10-hydroxycamptothecin in phases of liposome and water can be used to predict its absorption in small intestines of rats.
Suo
Xubin
X
Research and Development Institute of Traditional Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China. suoxubin04@yahoo.com.cn
Li
Muling
M
Wang
Yuqiang
Y
Zhu
Shengshan
S
D000818:Animals; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D002851:Chromatography, High Pressure Liquid; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000502:physiology; D007421:Intestine, Small / Q000378:metabolism*; D008081:Liposomes / Q000737:chemistry*; D051381:Rats; D014867:Water / Q000737:chemistry*
D008081:Liposomes; D014867:Water; C028098:10-hydroxycamptothecin; D002166:Camptothecin