title: Separation of flavonoids and phenolic acids in complex natural products by microemulsion electrokinetic chromatography using surfactant-coated and carboxylic single-wall carbon nanotubes as additives.
abstract: In this paper, we investigated the analytical potential of the use of single-walled carbon nanotubes (SWNTs) with different dispersion as additives in MEEKC. The addition of surfactant-coated single-walled carbon nanotubes (SC-SWNTs) in microemulsion provided a more efficient method than carboxylic SWNTs for the separation of three flavonoids and six phenolic acids depending on the interaction between the analytes and SWNTs surface. Additionally, the effect of important factors was examined by changing experimental variables such as the dispersion of SWNTs, surfactants and cosurfactants. Finally, the MEEKC method using SC-SWNTs was successfully applied to complex natural products (drug pair of Radix Astragali and Radix et Rhizoma Salvia Miltiorrhizae), with satisfactory results.
authors.affiliation: Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou, PR China. caojun91@163.com
authors.forename: Jun
authors.initials: J
authors.lastname: Cao
authors.forename: Haibin
authors.initials: H
authors.lastname: Qu
authors.forename: Yiyu
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification*; D018517:Plant Roots; D027561:Salvia miltiorrhiza; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D037742:Nanotubes, Carbon; D010636:Phenols; D012967:Sodium Dodecyl Sulfate