title: Evaluation of the immunogenicity and safety of an indigenously developed DTwP-Hib tetravalent combination vaccine (Shan 4) with EasyFourTM in Indian infants administered per EPI schedule: a phase III trial.
abstract: The study was planned to assess and compare immunogenicity and safety of an indigenous DTPw-Hib combination vaccine (Shan 4) with EasyFour, the available DTwP-Hib vaccine in India. Overall 210 healthy infants, six to eight weeks of age, were randomized to receive three doses of either Shan 4 or EasyFour at 6, 10 and 14 weeks of age. Antibodies were analyzed prior to and four to six weeks post third vaccine dose. Solicited and unsolicited local and systemic events in the follow up period after each dose were recorded. Post vaccination 100% of the infants in Shan 4 and EasyFour groups had seroprotective concentrations of Anti PRP-T IgG antibodies, IgG anti-diphtheria toxoid antibodies and IgG anti-tetanus toxoid antibodies. Following third dose of vaccination 86.99% subjects in the Shan 4 group and 73.85% subjects in the EasyFour group seroconverted for anti-pertussis antibody titres. Two Serious Adverse Events (SAE s) were reported during the course of the study, all unrelated to the respective vaccine administered. Most commonly reported adverse events in both the groups were pain at injection site, mild fever (<103°F) and minor swelling at injection site. The study proved that Shan 4 was safe and immunogenic compared to the available licensed vaccine.
authors.affiliation: Department of Pediatrics, 1St. Johns Medical College Hospital Bangalore, Karnataka, India.
authors.forename: Mandeep S
authors.initials: MS
authors.lastname: Dhingra
authors.forename: Raman
authors.initials: R
authors.lastname: Rao
authors.forename: Swarnarekha
authors.initials: S
authors.lastname: Bhat
authors.forename: Rajan
authors.initials: R
authors.lastname: Joshi
authors.forename: Veena
authors.initials: V
authors.lastname: Kalra
authors.forename: Harish R
authors.initials: HR
authors.lastname: Parikh
authors.forename: S Narasimha
authors.initials: SN
authors.lastname: Rao
authors.forename: G R
authors.initials: GR
authors.lastname: Sethi
authors.forename: Nitin
authors.initials: N
authors.lastname: Shah
authors.forename: M
authors.initials: M
authors.lastname: Muzaffaruddin
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*; D004487:Edema / Q000139:chemically induced; D005260:Female; D005334:Fever / Q000139:chemically induced; D018073:Haemophilus Vaccines / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary / Q000379:methods; D007194:India; D007223:Infant; D008297:Male; D010146:Pain / Q000139:chemically induced; D014611:Vaccination / Q000379:methods
chemical_list: D000907:Antibodies, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; C080881:diphtheria-tetanus-pertussis-haemophilus b conjugate vaccine