An imperfect rule for the particle roost.
Tetherin inhibits HIV and other enveloped viruses by grasping particles at the budding site and preventing their release. An article by Hinz and coworkers (Hinz et al., 2010) in this issue of Cell Host & Microbe reveals remarkable irregularities within the coiled-coil domain of the tetherin dimer that enhance flexibility of the molecule and contribute to its function.
Hammonds
Jason
J
Emory University and Children's Healthcare of Atlanta, 2015 Uppergate Drive, Atlanta, GA 30322, USA.
Spearman
Paul
P
Emory University and Children's Healthcare of Atlanta, 2015 Uppergate Drive, Atlanta, GA 30322, USA. Electronic address: paul.spearman@emory.edu.