Polymorphisms in DNA damage response genes and head and neck cancer risk.
BACKGROUND
Polymorphisms in DNA repair genes have been reported contributing factors in head and neck cancer risk but studies have shown conflicting results.


OBJECTIVE
To clarify the impact of DNA repair gene polymorphisms in head and neck cancer risk.


METHODS
A meta-analysis including 30 case-control studies was performed.


RESULTS
Marginally statistically significant association was found for XRCC1 codon 399 (for Caucasians only), XPD Asp312Asn and XRCC1 codon 194 variants and head and neck cancer.


CONCLUSIONS
Assessments of the effects of smoking, alcohol, human papillomavirus and race/ethnicity on the association between DNA repair gene polymorphisms and head and neck cancer are needed.
Flores-Obando
Rafael E
RE
Department of Epidemiology, State University of New York Downstate Medical Center, NY, USA.
Gollin
Susanne M
SM
Ragin
Camille C
CC
D016022:Case-Control Studies; D003062:Codon / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic; D000076105:X-ray Repair Cross Complementing Protein 1
D003062:Codon; D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human; C095888:xeroderma pigmentosum group F protein