Heparin-binding protein as a biomarker of circulatory failure during severe infections: a report of three cases.
We report 3 cases of disease - leptospirosis, tropical malaria and fulminant meningococcaemia - associated with high serum concentrations of heparin-binding protein (HBP) and haemodynamic instability. Furthermore, HBP kinetics were observed for the first 3 days in survivors and were correlated with improvement in clinical condition.
Beran
Ondrej
O
Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University in Prague and University Hospital Bulovka, Praha, Czech Republic.
Herwald
Heiko
H
Dzupová
Olga
O
Chalupa
Pavel
P
Holub
Michal
M
D000293:Adolescent; D000328:Adult; D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D016470:Bacteremia / Q000150:complications; D015415:Biomarkers; D001798:Blood Proteins; D002352:Carrier Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008288:Malaria / Q000150:complications; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000150:complications*; D012769:Shock / Q000175:diagnosis*
C062991:AZU1 protein, human; D023181:Antimicrobial Cationic Peptides; D015415:Biomarkers; D001798:Blood Proteins; D002352:Carrier Proteins