Hematopoietic stem cell transplantation after posttransplant lymphoproliferative disorder.
A 16-yr-old girl received liver transplantation for fulminant hepatitis. Aplastic anemia developed, and she received hematopoietic stem cell transplantation (HSCT). Eleven months after liver transplantation, abdominal lymph node enlargement and colon ulcers were observed, and colon biopsy showed posttransplant lymphoproliferative disorder (PTLD). Immunosuppression reduction was attempted, but it produced no therapeutic effect. Fourteen months after liver transplantation, she received a second HSCT due to engraftment failure, and PTLD resolved completely. The second HSCT can serve as cellular therapy for PTLD.
Kim
Min Joo
MJ
Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Kim
Inho
I
Bae
Hyun-Mi
HM
Seo
Kyungsuk
K
Park
Namjun
N
Yoon
Sung-Soo
SS
Park
Seonyang
S
Kim
Byoung Kook
BK
D000293:Adolescent; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000209:etiology* / Q000601:surgery*; D016896:Treatment Outcome