title: Veno-venous extracorporeal membrane oxygenation bridging to pharmacotherapy in pulmonary arterial hypertensive crisis.
abstract: We report the case of a treatment-naive patient with pulmonary arterial hypertension who presented with decompensated right ventricular failure and cardiogenic shock. Unstable hemodynamics, hypoxia and end-organ hypoperfusion limited up-titration of pharmacotherapy. Mechanical circulatory support with veno-venous extracorporeal membrane oxygenation (VV-ECMO) was initiated to permit dose titration of pulmonary vasodilator therapy. VV-ECMO was weaned after 10 days of support, with successful transition to intravenous epoprostenol and oral sildenafil.
authors.affiliation: Division of Cardiology, University of Maryland, Baltimore, MD, USA.
authors.forename: Mukta C
authors.initials: MC
authors.lastname: Srivastava
authors.forename: Gautam V
authors.initials: GV
authors.lastname: Ramani
authors.forename: Jose P
authors.initials: JP
authors.lastname: Garcia
authors.forename: Bartley P
authors.initials: BP
authors.lastname: Griffith
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Uber
authors.forename: Myung H
authors.initials: MH
authors.lastname: Park
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003131:Combined Modality Therapy; D011464:Epoprostenol / Q000008:administration & dosage / Q000627:therapeutic use*; D015199:Extracorporeal Membrane Oxygenation / Q000379:methods*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000628:therapy*; D007275:Injections, Intravenous; D010879:Piperazines / Q000008:administration & dosage / Q000627:therapeutic use*; D011687:Purines / Q000008:administration & dosage / Q000627:therapeutic use; D012770:Shock, Cardiogenic / Q000628:therapy; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use; D018497:Ventricular Dysfunction, Right / Q000628:therapy
chemical_list: D000959:Antihypertensive Agents; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate; D011464:Epoprostenol