title: Effect of anserine ingestion on the hyperglycemia and autonomic nerves in rats and humans.
abstract: Anserine and L-carnosine are similar dipeptides synthesized by muscles of vertebrates. The functional role of anserine is unknown, although previous studies showed hypoglycemic effects of carnosine through autonomic nerves. Thus, we evaluated the effects of anserine on blood glucose levels and neural activities. Intraperitoneal administration of specific doses of anserine to hyperglycemic rats reduced hyperglycemia and plasma glucagon concentrations, whereas thioperamide eliminated the effects of anserine. Intraduodenal injection of 0.1 mg anserine to anesthetized rats after laparotomy suppressed sympathetic nerve activity and enhanced activity of the vagal gastric efferent. In addition, oral administration of anserine reduced blood glucose levels during oral glucose tolerance testing in humans. These results suggest the possibility that anserine might be a control factor for blood glucose, and that histaminergic nerves may be involved in the hypoglycemic effects of anserine.
authors.affiliation: R&D of Functional Food Division, Yaizu Suisankagaku Industry Co., Ltd, Yaizu, Shizuoka, Japan. kubomura@yskf.co.jp
authors.forename: Daiki
authors.initials: D
authors.lastname: Kubomura
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Matahira
authors.forename: Katsuya
authors.initials: K
authors.lastname: Nagai
authors.forename: Akira
authors.initials: A
authors.lastname: Niijima
mesh_terms: D000818:Animals; D000861:Anserine / Q000037:antagonists & inhibitors / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001341:Autonomic Nervous System / Q000187:drug effects*; D001786:Blood Glucose / Q000032:analysis; D018592:Cross-Over Studies; D003847:Deoxyglucose / Q000008:administration & dosage / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D005934:Glucagon / Q000097:blood; D005951:Glucose Tolerance Test; D054828:Histamine H3 Antagonists / Q000494:pharmacology; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000037:antagonists & inhibitors / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D008297:Male; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013565:Sympatholytics / Q000494:pharmacology; D013997:Time Factors; D014630:Vagus Nerve / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D054828:Histamine H3 Antagonists; D007004:Hypoglycemic Agents; D007328:Insulin; D013565:Sympatholytics; D005934:Glucagon; D003847:Deoxyglucose; D000861:Anserine