Repeatability of retinal thickness measurements between spectral-domain and time-domain optical coherence tomography images in macular disease.
OBJECTIVE
To evaluate and compare the intra-session repeatability of retinal thickness measurements from the Topcon 3D OCT 1000 (Topcon Medical Systems; Paramus, NJ), a spectral-domain optical coherence tomography (SD-OCT) system, with the Stratus (Carl Zeiss Meditec, Inc., Dublin, CA), a time-domain OCT (TD-OCT) system, in eyes with retinal diseases.


METHODS
Repeated scans with both SD-OCT and TD-OCT were taken. Thickness measurements from high-quality scans were used to assess repeatability and compare measurements between the two instruments.


RESULTS
Paired scans from 127 eyes were evaluated, of which 63 pairs were of high quality. Coefficients of repeatability and variation for the central subfield were 20.1 μm (2.6%) with SD-OCT and 27.4 μm (4%) with TD-OCT (P = .38). The mean difference in central subfield thickness between the two instruments was 24.5 μm (standard deviation = 20.9).


CONCLUSIONS
Repeatability of retinal thickness measurements with the Topcon 3D OCT 1000 is comparable to the Stratus. The measurements of the two machines differ significantly and cannot be used interchangeably.
Domalpally
Amitha
A
Fundus Photograph Reading Center, Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Gangaputra
Sapna
S
Peng
Qian
Q
Danis
Ronald P
RP
D000886:Anthropometry; D001837:Body Weights and Measures; D003930:Diabetic Retinopathy / Q000175:diagnosis*; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation*; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis*; D008269:Macular Edema / Q000175:diagnosis*; D015203:Reproducibility of Results; D012160:Retina / Q000473:pathology*; D012170:Retinal Vein Occlusion / Q000175:diagnosis*; D041623:Tomography, Optical Coherence / Q000295:instrumentation*