title: [Melatonin injected into rat efficiently synchronizes the rhythm of protein synthesis in primary hepatocyte cultures isolated from this rat].
abstract: Melatonin injected intraperitoneally into rat synchronizes the ultradian rhythm of protein synthesis after 100 min in primary hepatocyte cultures isolated from this rat, which are studied after 1 or 2 days. The effective synchronization concentrations of melatonin--0.01-0.02 microg per kg of rat weight--are three orders lower than melatonin doses used in clinical practice in human treatment.
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Brodskiĭ
authors.forename: S I
authors.initials: SI
authors.lastname: Rapoport
authors.forename: T K
authors.initials: TK
authors.lastname: Dubovaia
authors.forename: N D
authors.initials: ND
authors.lastname: Zvezdina
authors.forename: V I
authors.initials: VI
authors.lastname: Fateeva
authors.forename: L A
authors.initials: LA
authors.lastname: Mal'chenko
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D022781:Hepatocytes / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D014176:Protein Biosynthesis / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D000975:Antioxidants; D008550:Melatonin