Copper-catalyzed cyanation of heterocycle carbon-hydrogen bonds.
A method for regioselective cyanation of heterocycles has been developed. A number of aromatic heterocycles as well as azulene can be cyanated in reasonable to good yields by using a copper cyanide catalyst and an iodine oxidant.
Do
Hien-Quang
HQ
Department of Chemistry, University of Houston, Houston, Texas 77204-5003, USA.
Daugulis
Olafs
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D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry; D015394:Molecular Structure; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D013237:Stereoisomerism
D009570:Nitriles; D003300:Copper; D007455:Iodine