title: Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy.
abstract: BACKGROUND
  Recent data have demonstrated increased lipid peroxidation (LPO) levels and oxidative stress in periodontitis. Malondialdehyde (MDA) and superoxide dismutase (SOD) are both increased during oxidative stress. Furthermore, this study examined SOD concentration, total oxidative status (TOS) and MDA levels in periodontal patients and investigated the longitudinal effect of periodontal therapy on the index levels of chronic periodontitis (CP) patients.
  
  
  METHODS
  Serum, saliva and gingival crevicular fluid (GCF) samples were obtained from 48 CP patients and 35 healthy control subjects prior to, as well as after 16 weeks following non-surgical post-periodontal therapy. MDA, TOS and SOD and clinical parameters were determined pre- and post-therapy.
  
  
  RESULTS
  The levels of TOS and SOD values were significantly higher in the CP group than in the control group (p < 0.05), but only MDA in GCF. Post-periodontal therapy, serum, saliva and GCF TOS and SOD levels significantly decreased compared to basal levels (p < 0.05), but only MDA in GCF.
  
  
  CONCLUSIONS
  LPO was higher in the periodontal region, with TOS and SOD increasing both locally and peripherally. Non-surgical therapy can restore and control the subject antioxidant capacity by locally and systemically modifying the levels of MDA, TOS and SOD.
authors.affiliation: Changzhou Traditional Chinese Medical Hospital, Changzhou, Jiangsu Province, China.
authors.forename: D
authors.initials: D
authors.lastname: Wei
authors.forename: X-L
authors.initials: XL
authors.lastname: Zhang
authors.forename: Y-Z
authors.initials: YZ
authors.lastname: Wang
authors.forename: C-X
authors.initials: CX
authors.lastname: Yang
authors.forename: G
authors.initials: G
authors.lastname: Chen
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging; D055113:Chronic Periodontitis / Q000097:blood / Q000378:metabolism / Q000628:therapy*; D003774:Dental Plaque Index; D012534:Dental Scaling; D005260:Female; D005500:Follow-Up Studies; D016166:Free Radical Scavengers / Q000032:analysis / Q000097:blood*; D005883:Gingival Crevicular Fluid / Q000737:chemistry* / Q000201:enzymology; D005884:Gingival Hemorrhage / Q000628:therapy; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology*; D008137:Longitudinal Studies; D008297:Male; D008315:Malondialdehyde / Q000032:analysis / Q000097:blood; D009910:Oral Hygiene; D016877:Oxidants / Q000032:analysis / Q000097:blood*; D018384:Oxidative Stress / Q000502:physiology; D017622:Periodontal Attachment Loss / Q000628:therapy; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000628:therapy; D010519:Periodontium / Q000201:enzymology / Q000378:metabolism; D011859:Radiography; D016745:Root Planing; D012463:Saliva / Q000737:chemistry* / Q000201:enzymology; D013357:Subgingival Curettage; D013482:Superoxide Dismutase / Q000032:analysis / Q000097:blood*
chemical_list: D016166:Free Radical Scavengers; D016877:Oxidants; D008315:Malondialdehyde; D013482:Superoxide Dismutase