The immunological synapse: a focal point for endocytosis and exocytosis.
There are many different cells in the immune system. To mount an effective immune response, they need to communicate with each other. One way in which this is done is by the formation of immunological synapses between cells. Recent developments show that the immune synapse serves as a focal point for exocytosis and endocytosis, directed by centrosomal docking at the plasma membrane. In this respect, formation of the immunological synapse bears striking similarities to cilia formation and cytokinesis. These intriguing observations suggest that the centrosome may play a conserved role in designating a specialized area of membrane for localized endocytosis and exocytosis.
Griffiths
Gillian M
GM
Cambridge Institute for Medical Research, Addenbrooke's Hospital, Cambridge, England, UK. gg305@cam.ac.uk
Tsun
Andy
A
Stinchcombe
Jane C
JC
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002923:Cilia / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology*; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D054992:Immunological Synapses / Q000502:physiology*; D008954:Models, Biological; D017729:Presynaptic Terminals / Q000502:physiology; D013569:Synapses / Q000378:metabolism