title: Dose-dense chemotherapy in metastatic gastric cancer with a modified docetaxel-cisplatin-5-fluorouracil regimen.
abstract: OBJECTIVE
  Previous studies have reported that in early breast cancer, lymphomas and advanced bladder cancer, dose-dense chemotherapy may be more effective than conventional treatments. In metastatic gastric cancer, chemotherapy with docetaxel, cisplatin and 5-fluorouracil (TCF) q3w is very active, and, even though there is no international consensus on the subject, it is the regimen of choice of many European centers as first-line chemotherapy in this subset of patients. Based on these studies, we tested for the first time the feasibility and activity of an intensified dose-dense TCF regimen (q2w) modifying the 5-fluorouracil infusion with 1-folinic acid/5-fluorouracil according to the "De Gramont regimen".
  
  
  METHODS
  Patients with histologically confirmed measurable metastatic gastric cancer, ECOG performance status <or=1, and not previously treated for advanced disease received docetaxel, 85 mg/m(2) (75 mg/m(2) after the first 6 patients, 70 mg/m(2) after the 19th patient) on day 1, cisplatin, 75 mg/m(2) on day 1 (60 mg/m(2) after the 19th patient), 1-folinic acid, 100 mg/m(2) on days 1 and 2, followed by 5-fluorouracil, 400 mg/m(2) bolus on days 1 and 2 and then 600 mg/m(2) as a 22-h continuous infusion on days 1 and 2, every 14 days, plus pegfilgrastim, 6 mg on day 3. Patients aged >or=65 years received the same schedule with a dose reduction of 30%.
  
  
  RESULTS
  Thirty-two consecutive patients were enrolled (63% male, 37% female); median age, 64 years (range, 40-81). A median of 4 cycles (range, 1-7) per patient was administered. Eleven of 32 patients (34%) required a dose reduction, mostly for hematological grade III-IV toxicity and severe asthenia. Twelve patients (38%) completed the first 4 cycles of therapy within 7 weeks, thereby finishing without delay the initially planned dose-density schedule. Twenty-eight patients were evaluated for response (1 early suspension after the first cycle because of toxicity, 3 deaths before response evaluation due to progression of disease). There were 3 complete responses (9%), 15 partial responses (47%), 7 stable disease (22%) and 3 progression of disease (9%), for an overall response rate, by intention to treat, of 56% (95% CI, 39-73). The most frequent grade 3-4 toxicities were: neutropenia (53%), thrombocytopenia (34%), anemia (16%) febrile neutropenia (22%), asthenia (38%) and diarrhea (19%). Median time to progression was 9.1 months (95% CI, 6.0-12.2); median overall survival was 10.1 months (95% CI, 8.8-12.2).
  
  
  CONCLUSIONS
  A dose-dense TCF regimen in metastatic gastric cancer is feasible, with activity comparable to previous results achieved with epirubicin-based chemotherapy and TCF q3wk in terms of overall survival and time to progression, and deserves to be further tested in randomized phase III studies.
authors.affiliation: Medical Oncology Division, Azienda Istituti Ospitalieri di Cremona, Italy. g.tomasello@ospedale.cremona.it
authors.forename: Gianluca
authors.initials: G
authors.lastname: Tomasello
authors.forename: Matteo Dalla
authors.initials: MD
authors.lastname: Chiesa
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Buti
authors.forename: Matteo
authors.initials: M
authors.lastname: Brighenti
authors.forename: Federica
authors.initials: F
authors.lastname: Negri
authors.forename: Rodrigo Kraft
authors.initials: RK
authors.lastname: Rovere
authors.forename: Mario
authors.initials: M
authors.lastname: Martinotti
authors.forename: Massimo
authors.initials: M
authors.lastname: Buononato
authors.forename: Antonio
authors.initials: A
authors.lastname: Brunelli
authors.forename: Silvia
authors.initials: S
authors.lastname: Lazzarelli
authors.forename: Gianvito
authors.initials: G
authors.lastname: Donati
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Passalacqua
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects*; D001247:Asthenia / Q000139:chemically induced; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003967:Diarrhea / Q000139:chemically induced; D018572:Disease-Free Survival; D000077143:Docetaxel; D005240:Feasibility Studies; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006402:Hematologic Diseases / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D009367:Neoplasm Staging; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016019:Survival Analysis; D043823:Taxoids / Q000008:administration & dosage / Q000009:adverse effects; D016896:Treatment Outcome; D014839:Vomiting / Q000139:chemically induced
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D002945:Cisplatin; D005472:Fluorouracil