First principles design of derivatizing agent for direct determination of enantiomeric purity of chiral alcohols and amines by NMR spectroscopy.
(77)Se NMR offers superior sensing of chirality within the structure of the diastereomers (Deltadelta up to 6.1 ppm), compared to (13)C (Deltadelta < 1 ppm) and (1)H (Deltadelta < 0.2 ppm). The developed procedure is equally well suitable for determination of the enantiomeric purity of chiral alcohols and amines as pure samples as well as reaction mixtures and crude products.
Orlov
Nikolay V
NV
Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Pr. 47, Moscow, 119991, Russia.
Ananikov
Valentine P
VP