title: Synthesis and glycogen phosphorylase inhibitor activity of functionalized 1,4-benzodioxanes.
abstract: A series of novel 1,4-benzodioxanes 11a-e and rac-12a-d carrying thiazolidine-2,4-dione moiety was synthesized and their glycogen phosphorylase inhibitor activity was also evaluated.
authors.affiliation: Department of Organic Chemistry, Research Group for Carbohydrates of Hungarian Academy of Sciences, Debrecen, Hungary. czakoz@yahoo.com
authors.forename: Z
authors.initials: Z
authors.lastname: Czakó
authors.forename: T
authors.initials: T
authors.lastname: Docsa
authors.forename: P
authors.initials: P
authors.lastname: Gergely
authors.forename: L
authors.initials: L
authors.lastname: Juhász
authors.forename: S
authors.initials: S
authors.lastname: Antus
mesh_terms: D002855:Chromatography, Thin Layer; D004146:Dioxanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D024981:Glycogen Phosphorylase / Q000037:antagonists & inhibitors*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship
chemical_list: D004146:Dioxanes; D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; D007202:Indicators and Reagents; D024981:Glycogen Phosphorylase