Direct sequencing of the human microbiome readily reveals community differences.
Culture-independent studies of human microbiota by direct genomic sequencing reveal quite distinct differences among communities, indicating that improved sequencing capacity can be most wisely utilized to study more samples, rather than more sequences per sample.
Kuczynski
Justin
J
Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
Costello
Elizabeth K
EK
Nemergut
Diana R
DR
Zaneveld
Jesse
J
Lauber
Christian L
CL
Knights
Dan
D
Koren
Omry
O
Fierer
Noah
N
Kelley
Scott T
ST
Ley
Ruth E
RE
Gordon
Jeffrey I
JI
Knight
Rob
R
D001419:Bacteria / Q000235:genetics*; D001483:Base Sequence; D004194:Disease; D017753:Ecosystem; D006801:Humans; D054892:Metagenome / Q000235:genetics*; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA / Q000379:methods*