title: Intracellular penetration and activity of UB-8902 in human polymorphonuclear leukocytes.
abstract: The intracellular penetration and activity of UB-8902 in human polymorphonuclear leukocytes was evaluated. Intracellular UB-8902 concentrations were 6-fold higher than extracellular levels. Uptake was rapid, reversible, saturable, and affected by external pH. UB-8902 showed intracellular activity against Staphylococcus aureus strains presenting mutations associated with fluoroquinolone resistance in the gyrA and/or grlA genes.
authors.affiliation: Departmento de Microbiología, Facultad de Medicina, Universidad de Sevilla, Seville, Spain. mudarra@us.es
authors.forename: Sofía
authors.initials: S
authors.lastname: Ballesta
authors.forename: Isabel
authors.initials: I
authors.lastname: García
authors.forename: Javier
authors.initials: J
authors.lastname: Sánchez-Céspedez
authors.forename: Jordi
authors.initials: J
authors.lastname: Vila
authors.forename: Alvaro
authors.initials: A
authors.lastname: Pascual
mesh_terms: D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006801:Humans; D009504:Neutrophils / Q000378:metabolism*
chemical_list: D000890:Anti-Infective Agents; C556897:UB 8902; D002939:Ciprofloxacin