title: Extrahepatic disorders of HCV infection: a distinct entity of B-cell neoplasia?
abstract: Some infectious agents have been associated with B-cell lymphoma development. In the last decades, it has been demonstrated that patients infected by hepatitis C virus (HCV) are more likely to develop B-cell non-Hodgkin's lymphoma (NHL) than those uninfected. The prevalence of HCV-infection among NHL patients is reported in this review of all Italian studies on NHL and HCV infection, both case-control and case series. From 18 studies, the prevalence of anti-HCV antibodies in 2736 NHL patients was 19.7% (range: 8.3-37.1%). The association of HCV-infection with each NHL histotype in case-control studies is discussed. Molecular mechanisms by which HCV infection promotes B-cell NHL development is also explored and indicate that HCV-associated lymphomas may be a distinct entity. Clarification of these mechanisms may improve diagnosis, classification and therapy of this subset of NHL. Finally, treatment of HCV-positive patients with lymphoproliferative disorders are herein summarized and further support the notion that HCV infection contributes to the development of these pathologic conditions.
authors.affiliation: Department of Biomedical Sciences, University of Catania, I-95124 Catania, Italy. mlibra@unict.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Libra
authors.forename: Jerry
authors.initials: J
authors.lastname: Polesel
authors.forename: Alessia Erika
authors.initials: AE
authors.lastname: Russo
authors.forename: Vallì
authors.initials: V
authors.lastname: De Re
authors.forename: Diana
authors.initials: D
authors.lastname: Cinà
authors.forename: Diego
authors.initials: D
authors.lastname: Serraino
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Nicoletti
authors.forename: Demetrios A
authors.initials: DA
authors.lastname: Spandidos
authors.forename: Franca
authors.initials: F
authors.lastname: Stivala
authors.forename: Renato
authors.initials: R
authors.lastname: Talamini
mesh_terms: D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000453:epidemiology / Q000821:virology*; D015995:Prevalence