title: Split-brain syndrome after hepatic transplantation: a tacrolimus-related vasculitis?
abstract: An unusual case of inter-haemispheric disconnection syndrome occurring in a patient who had undergone hepatic transplantation is presented. The underlying disorder, at first wrongly interpreted as encephalitis, was found to be severe, diffuse cerebral vasculitis. The hypothesis that treatment with tacrolimus might have caused, or at least favoured the vascular damage is discussed.
authors.affiliation: Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy.
authors.forename: Sara
authors.initials: S
authors.lastname: Montagnese
authors.forename: Sami
authors.initials: S
authors.lastname: Schiff
authors.forename: Carlo
authors.initials: C
authors.lastname: Poci
authors.forename: Pamela
authors.initials: P
authors.lastname: Iannizzi
authors.forename: Anna
authors.initials: A
authors.lastname: Biancardi
authors.forename: Renzo
authors.initials: R
authors.lastname: Manara
authors.forename: Chiara
authors.initials: C
authors.lastname: Briani
authors.forename: Daniela
authors.initials: D
authors.lastname: Mapelli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Realdi
authors.forename: Piero
authors.initials: P
authors.lastname: Amodio
mesh_terms: D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D002533:Cerebral Angiography; D002544:Cerebral Infarction / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D003337:Corpus Callosum / Q000098:blood supply / Q000473:pathology; D004185:Disability Evaluation; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D050812:Split-Brain Procedure / Q000009:adverse effects*; D016559:Tacrolimus / Q000009:adverse effects*; D014657:Vasculitis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology
chemical_list: D016559:Tacrolimus