title: Centriole, differentiation, and senescence.
abstract: Irreversible differentiation (change of morphogenetic status) and programmed death (apoptosis) are observed only in somatic cells, and cell division is the only way by which the morphogenetic status of the offspring cells may be modified. It is known that there is a fixed limit to the number of possible cell divisions, the so-called Hayflick limit. Existing links between cell division, differentiation, and apoptosis make it possible to conclude that all of these processes could be controlled by a single self-reproducing structure. Potential candidates for this replicable structure in a somatic cell are the chromosomes, mitochondria (both contain DNA), and centrioles. Centrioles (a diplosome, or pair of centrioles) are the most likely unit that can fully regulate the processes of irreversible differentiation, determination, and modification of the morphogenetic status. Centrioles may contain differently encoded RNA molecules stacked in a definite order, and during mitosis, these RNA molecules are released one by one into the cytoplasm. In the presence of reverse transcriptase and endonuclease, processing of this RNA presumably changes the status of repressed and potentially active genes and, subsequently, the morphogenetic status of a cell.
authors.affiliation: A Natishvili Institute of Morphology, Tbilisi, Georgia 0159. jaba@tkemaladze.ge
authors.forename: J
authors.initials: J
authors.lastname: Tkemaladze
authors.forename: K
authors.initials: K
authors.lastname: Chichinadze
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D002502:Centrioles / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D034741:RNA, Small Interfering / Q000378:metabolism / Q000502:physiology
chemical_list: D034741:RNA, Small Interfering