[Oral cyclosporine microemulsion for the treatment of severe chronic idiopathic ulcerative colitis refractory to intravenous steroids: experience in two cases.].
There have been important advances in the treatment of severe forms of ulcerative colitis (UC). They include biologic therapy and immunomodulators such as cyclosporine. The primary end-point of these therapies is to avoid colectomy in patients with severe disease when intravenous steroids have failed. Cyclosporine has been successful for induction of remission in severe UC, but undesirable side effects present quickly after intravenous delivery. We report two cases with severe UC that were successfully treated with oral microemulsion form of cyclosporine.
Coss-Adame
E
E
Clínica de Enfermedad Inflamatoria Intestinal, Departamento de Gastroenterología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, D. F. ecossmex@hotmail.com
Barahona-Garrido
J
J
Yamamoto-Furusho
J K
JK
D000284:Administration, Oral; D000328:Adult; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D016572:Cyclosporine / Q000008:administration & dosage*; D004655:Emulsions; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D012720:Severity of Illness Index; D017211:Treatment Failure
D004655:Emulsions; D005938:Glucocorticoids; D016572:Cyclosporine; D011241:Prednisone