title: Metastatic oligodendroglioma: a case report and incidence in The Netherlands.
abstract: Oligodendroglioma is a tumor of the central nervous system which rarely metastasizes. The diagnosis of oligodendroglioma is based on histomorphology with limited use of immunohistochemistry. However, recently a specific 1p/19q codeletion has been found which can be demonstrated by in situ hybridization. We report a case of a 58-years-old man with a 31-months history of oligodendroglioma presenting with fatigue and anemia. A bone marrow biopsy demonstrated massive localization of oligodendroglioma which was confirmed by in situ hybridization for the 1p/19q deletion. In addition we studied data from PALGA, the nationwide network and registry of histo- and cytopathology in the Netherlands and found an incidence of approximately 2 in 1,000 for metastasis of oligodendroglioma outside the central nervous system.
authors.affiliation: Laboratory of Pathology, Dordrecht, Elisabeth Hospital, Tilburg and 3Department of internal medicine, Beatrix Hospital, Gorinchem, The Netherlands.
authors.forename: J L M
authors.initials: JL
authors.lastname: Krijnen
authors.forename: R E M
authors.initials: RE
authors.lastname: Fleischeur
authors.forename: M
authors.initials: M
authors.lastname: van Berkel
authors.forename: P J
authors.initials: PJ
authors.lastname: Westenend
mesh_terms: D001706:Biopsy; D019046:Bone Marrow Neoplasms / Q000453:epidemiology* / Q000556:secondary*; D001932:Brain Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D009837:Oligodendroglioma / Q000453:epidemiology* / Q000556:secondary*