Melatonin-analog, beta-methyl-6-chloromelatonin, supplementation in spinal cord injury.
Spinal cord injury (SCI) is a devastating condition. Melatonin supplementation has been shown to lessen SCI, but its use has been limited by its side effect profile. In this work, rats underwent a moderate-to-severe contussional SCI with either placebo or beta-methyl-6-chloromelatonin, 10mg/kg or 100mg/kg supplementation. The 10mg/kg supplementation demonstrated benefit; the 100mg/kg dosage was limited by toxicity. This is the first work to assess a melatonin analog in SCI.
Fee
Dominic B
DB
Department of Neurology, University of Kentucky Chandler Medical Center, Lexington, KY, USA. dbfee2@email.uky.edu
Swartz
Karin R
KR
Scheff
Nicole
N
Roberts
Kelly
K
Gabbita
Prasad
P
Scheff
Stephen
S
D000818:Animals; D019587:Dietary Supplements; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D008550:Melatonin / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D009474:Neurons / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D018696:Neuroprotective Agents / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000187:drug effects* / Q000473:pathology; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000473:pathology
D018696:Neuroprotective Agents; C489883:beta-methyl-6-chloromelatonin; D008550:Melatonin