Molecular structure of sarcomere-to-membrane attachment at M-Lines in C. elegans muscle.
C. elegans is an excellent model for studying nonmuscle cell focal adhesions and the analogous muscle cell attachment structures. In the major striated muscle of this nematode, all of the M-lines and the Z-disk analogs (dense bodies) are attached to the muscle cell membrane and underlying extracellular matrix. Accumulating at these sites are many proteins associated with integrin. We have found that nematode M-lines contain a set of protein complexes that link integrin-associated proteins to myosin thick filaments. We have also obtained evidence for intriguing additional functions for these muscle cell attachment proteins.
Qadota
Hiroshi
H
Department of Pathology, Emory University, Atlanta, GA 30322, USA.
Benian
Guy M
GM
D000818:Animals; D017173:Caenorhabditis elegans / Q000737:chemistry / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D029742:Caenorhabditis elegans Proteins / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D022001:Focal Adhesions / Q000502:physiology; D016023:Integrins / Q000502:physiology; D009124:Muscle Proteins / Q000502:physiology; D009132:Muscles / Q000737:chemistry / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D012518:Sarcomeres / Q000737:chemistry / Q000502:physiology* / Q000648:ultrastructure
D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D016023:Integrins; D009124:Muscle Proteins