[Elements for the effective evaluation of natural products with possible antihypertensive effects].
Within the context of experimental pharmacology, some criteria are discussed for estimating the potential of natural products with possible pharmacological activity for the treatment of hypertension. This disorder has great epidemiological impact in Colombia as well as elsewhere. Discovery of these products can be accomplished by use of accessible pharmacological tests such as the following: developing models of arterial hypertension in the laboratory rat, in vitro tests, in vivo tests and microscopic analysis. Suitable protocols associated with these techniques can capture valuable information about possible effects on hypertension during the evaluation phase of a natural product.
Guerrero
Mario Francisco
MF
Departamento de Farmacia, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá, D.C, Colombia. mfguerrerop@unal.edu.co
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001011:Aorta / Q000187:drug effects; D001688:Biological Products / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy / Q000235:genetics; D008519:Medicine, Traditional; D023421:Models, Animal; D019331:NG-Nitroarginine Methyl Ester / Q000633:toxicity; D020030:Nitric Oxide Donors / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D028321:Plant Preparations / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D020303:Rats, Inbred Dahl; D011918:Rats, Inbred SHR; D012084:Renin-Angiotensin System / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use; D020257:Ventricular Remodeling / Q000187:drug effects
D000959:Antihypertensive Agents; D001688:Biological Products; D020030:Nitric Oxide Donors; D028321:Plant Preparations; D014665:Vasodilator Agents; D019331:NG-Nitroarginine Methyl Ester