title: Carcinomatous meningitis associated with ovarian cancer complicated by SIADH.
abstract: We experienced a case of carcinomatous meningitis originating from stage IIIc ovarian cancer complicated by syndrome of inappropriate antidiuretic hormone secretion (SIADH). A 51-year-old woman had been treated with multiple chemotherapy regimens after an initial operation for ovarian cancer. During the last chemotherapy regimen, she suffered headache, mood changes and ataxia. After one week, she had a convulsive seizure and lost consciousness. Laboratory studies showed hyponatremia, low serum osmolality, elevated urinary sodium level and urine osmolality. Cranial-enhanced magnetic resonance imaging (MRI) revealed abnormal meningeal enhancement. A lumbar puncture examination revealed that numerous atypical cells were present. Carcinomatous meningitis complicated by SIADH was diagnosed and treatment for hyponatremia and whole brain radiotherapy were performed; however, she died two weeks after the radiation therapy. Clinicians should consider carcinomatous meningitis when there are findings of SIADH.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama, Japan.
authors.forename: Toru
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Akitoshi
authors.initials: A
authors.lastname: Nakashima
authors.forename: Miho
authors.initials: M
authors.lastname: Ishimaru
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shima
authors.forename: Takao
authors.initials: T
authors.lastname: Hidaka
authors.forename: Shigeru
authors.initials: S
authors.lastname: Saito
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000150:complications* / Q000532:radiotherapy; D008279:Magnetic Resonance Imaging; D055756:Meningeal Carcinomatosis / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D017211:Treatment Failure
chemical_list: D000970:Antineoplastic Agents