title: Sodium sensitivity of blood pressure in Chinese populations.
abstract: Clinical trials have demonstrated that a reduced intake of dietary sodium lowers blood pressure. However, blood pressure reduction in response to a decrease in dietary sodium intake varies considerably among different individuals-a phenomenon described as sodium sensitivity. The Genetic Epidemiology Network of Salt Sensitivity (GenSalt) study was a large family-based dietary-feeding study conducted in rural north China. This study indicated that approximately 39% of Chinese adults were sodium-sensitive. Sodium sensitivity was more common in women and in persons who were older and had higher usual blood pressure. Sodium sensitivity was also more common in individuals with higher responses to a cold pressor test and in individuals with the metabolic syndrome. Genetic factors may play an important role in determining sodium sensitivity in the Chinese population. A better understanding of the genetic and environmental determinants of sodium sensitivity has important public health and clinical implications.
authors.affiliation: Department of Medicine, Tulane University School of Medicine, SL45, New Orleans, LA 70112, USA. jchen@tulane.edu
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
mesh_terms: D000328:Adult; D000367:Age Factors; D001794:Blood Pressure; D002681:China / Q000453:epidemiology; D016001:Confidence Intervals; D005260:Female; D005843:Geography; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000178:diet therapy* / Q000453:epidemiology; D008019:Life Style; D008297:Male; D024821:Metabolic Syndrome; D008875:Middle Aged; D015999:Multivariate Analysis; D009749:Nutrition Surveys; D009752:Nutritional Status; D016017:Odds Ratio; D012424:Rural Population; D012737:Sex Factors; D017673:Sodium Chloride, Dietary / Q000009:adverse effects / Q000378:metabolism*; D011795:Surveys and Questionnaires
chemical_list: D017673:Sodium Chloride, Dietary