title: The advancement of predictive diagnosis and molecular mechanism in multiple primary lung cancer.
abstract: Due to the advanced diagnostic technique and better understanding for multiple primary lung cancers (MPLC), the increasing incidence of MPLC has been reported. Very often, MPLC are misdiagnosed as metastasis because of lacking efficient molecular biomarkers for prediction and diagnosis. Studies on the molecular mechanism for tumorgenesis and progression of MPLC may therefore facilitate the discovery of biomarkers for disease diagnosis and prognosis, so that an individual and rational treatment can be achieved. We tried to further our understanding and improve the diagnostic skill for MPLC by reviewing the current status and the latest advancement of molecular markers related to MPLC.
authors.affiliation: Department of Cardiovascular Thoracic Surgery, West China Hospital, Sichuan University. Chengdu, Sichuan 610041, PR China.
authors.forename: Lan
authors.initials: L
authors.lastname: Yuan
authors.forename: Lun-Xu
authors.initials: LX
authors.lastname: Liu
authors.forename: Guo-Wei
authors.initials: GW
authors.lastname: Che
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology; D014408:Biomarkers, Tumor / Q000032:analysis; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000532:radiotherapy; D018288:Carcinoma, Small Cell / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D002872:Chromosome Deletion; D004249:DNA Damage; D016147:Genes, Tumor Suppressor; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D012907:Smoking / Q000009:adverse effects
chemical_list: D014408:Biomarkers, Tumor