The comparison of hair from gastric cancer patients and from healthy persons studied by infrared microspectroscopy and imaging using synchrotron radiation.
OBJECTIVE
The objective is to apply synchrotron-based FTIR microspectroscopy and imaging to human hair tissue and investigate the possibility of the method in gastric cancer research and diagnosis.


METHODS
Human hair from gastric cancer patients' scalp and normal persons' scalp were studied by synchrotron-based FTIR microspectroscopy and imaging.


RESULTS
The micro-spectra and imaging show the difference between the normal and malignant hair tissues. Obvious peak shift of symmetric phosphate band is observed in micro-spectra of medulla region for the hair tissue of gastric cancer patients. Chemical imaging shows the distributions of lipid and amide II/v(s)PO(2)(-) have changed in the gastric cancer cases.


CONCLUSIONS
The study indicates that the hair tissue's infrared microspectroscopy and imaging using synchrotron will be a potentially useful method for rapid early gastric cancer diagnosis.
Wang
Xin
X
University of Science and Technology of China, Anhui 230029, China.
Qi
Zeming
Z
Liu
Xingcun
X
Wang
Shengyi
S
Li
Chengxiang
C
Liu
Gang
G
Xiong
Yin
Y
Li
Tingting
T
Tao
Jinqiu
J
Tian
Yangchao
Y
D000577:Amides / Q000032:analysis; D016022:Case-Control Studies; D003952:Diagnostic Imaging / Q000295:instrumentation*; D005260:Female; D006197:Hair / Q000737:chemistry*; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008297:Male; D011379:Prognosis; D012535:Scalp / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013274:Stomach Neoplasms / Q000175:diagnosis*; D017356:Synchrotrons
D000577:Amides; D008055:Lipids