title: A novel sensor for cephalosporins based on electrocatalytic oxidation by poly(o-anisidine)/SDS/Ni modified carbon paste electrode.
abstract: In this work for first time, the electrocatalytic oxidations of some cephalosporins were carried out by poly(o-anisidine)/SDS/Ni modified carbon paste electrode using cyclic voltammetry, chronoamperometry and chronocoulometry methods. At first, poly(o-anisidine) was formed by cyclic voltammetry in monomer solution containing sodium dodesyl sulfate (SDS), on carbon paste electrode surface. Then, Ni(II) ions were incorporated to electrode by immersion of the polymeric modified electrode having amine group in 0.1molL(-1) Ni(II) ion solution. A good redox behavior was observed for the Ni(OH)(2)/NiOOH couple on the surface of this electrode. Cephalosporins were successfully oxidized on the surface of this nickel ions dispersed poly(o-anisidine) modified carbon paste electrode. The electrocatalytic oxidation peak currents of cephalosporins were linearly dependent on their concentration. Electrode was successfully applied to determine cephalosporins in pharmaceutical preparations.
authors.affiliation: Electroanalytical Chemistry Research Laboratory, Faculty of Chemistry, Mazandaran University, Babolsar, Iran. fer-o@umz.ac.ir
authors.forename: Reza
authors.initials: R
authors.lastname: Ojani
authors.forename: Jahan-Bakhsh
authors.initials: JB
authors.lastname: Raoof
authors.forename: Saeed
authors.initials: S
authors.lastname: Zamani
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D015374:Biosensing Techniques; D002384:Catalysis; D020682:Cefixime / Q000032:analysis; D015296:Ceftizoxime / Q000032:analysis; D002443:Ceftriaxone / Q000032:analysis; D002511:Cephalosporins / Q000032:analysis* / Q000302:isolation & purification; D002623:Chemistry Techniques, Analytical; D004563:Electrochemistry / Q000379:methods*; D004566:Electrodes; D008956:Models, Chemical; D009532:Nickel / Q000737:chemistry; D010100:Oxygen / Q000737:chemistry*; D012967:Sodium Dodecyl Sulfate / Q000737:chemistry; D012997:Solvents / Q000737:chemistry
chemical_list: D000814:Aniline Compounds; D002511:Cephalosporins; D012997:Solvents; D012967:Sodium Dodecyl Sulfate; D002443:Ceftriaxone; D009532:Nickel; D020682:Cefixime; D015296:Ceftizoxime; C003898:2-anisidine; D010100:Oxygen