[Uptake1 inibition in reperfusion: noradrenalin dynamic and myocardiola infraction size].
To determine the effect of uptake 1 inhibition in reperfusion after myocardial ischcmia upon noradrenalin dynamic and myocardial infarction size, 14 male Wistar rats anesthetized with urethane were randomly divided into 2 groups and subjected to 30 min coronary occlusion and subsequent 120 min reperfusion. In control group (n = 7) 1 ml of Ringer's solution was administered intravenously at the beginning of reperfusion. In experimental group (n = 7) instead of Ringer's solution 0.8 mg/kg of desipramine was used. Myocardial interstitial noradrenalin levels were measured using a microdialysis technique. Infarction size was determined by triphenyltetrazolium chloride staining and was related to the area at risk. Desipramine increased infraction size from 32.0 +/- 3.1 % (control group) to 46.1 +/- 3.4% (p = 0.06). Interstitial noradrenalin in experimental group did not decrease during 120 min reperfusion (p < 0.05 vs. control). The data obtained suggest that uptake 1 inhibition in reperfusion after myocardial ischemia increases myocardial infarction size through increased interstitial noradrenalin.
Naumenko
S E
SE
Latysheva
T V
TV
Gilinskiĭ
M A
MA
D000818:Animals; D003891:Desipramine / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D015424:Reperfusion
D004791:Enzyme Inhibitors; D003891:Desipramine; D009638:Norepinephrine