title: Distinctively low levels of serum 8-hydroxydeoxyguanosine in women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To investigate oxidative stress and angiogenetic factors in polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Prospective cohort study.
  
  
  METHODS
  University outpatient clinic.
  
  
  METHODS
  Fifty women with PCOS were divided into two groups: body mass index (BMI) >27 kg/m(2) (n = 25) and BMI <27 kg/m(2) (n = 25). The control group consisted of 20 age- and BMI-matched healthy women.
  
  
  METHODS
  None.
  
  
  METHODS
  Enzyme-linked immunosorbent assays were used to measure serum levels of 8-hydroxydeoxyguanosine (8-OHdG), angiopoietin-2, and vascular endothelial growth factor (VEGF).
  
  
  RESULTS
  Women with PCOS had significantly lower serum 8-OHdG levels (mean 137.8 pg/mL, range 53.4-282.9 pg/mL) compared with the control subjects (mean 219.78 pg/mL, 124.6-372.4 pg/mL). This difference was obvious in both lean (BMI <27 kg/m(2)) and obese (BMI >27 kg/m(2)) subjects. Concentrations of VEGF were higher among obese subjects with PCOS.
  
  
  CONCLUSIONS
  Serum 8-OHdG levels are significantly lower in women with PCOS than in healthy controls. The clinical significance of this finding is discussed.
authors.affiliation: Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland. henrijuh@mail.student.oulu.fi
authors.forename: Henri
authors.initials: H
authors.lastname: Sova
authors.forename: Laure
authors.initials: L
authors.lastname: Morin-Papunen
authors.forename: Ulla
authors.initials: U
authors.lastname: Puistola
authors.forename: Peeter
authors.initials: P
authors.lastname: Karihtala
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D042702:Angiopoietin-2 / Q000097:blood / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000378:metabolism; D015536:Down-Regulation; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000378:metabolism; D055815:Young Adult
chemical_list: D042702:Angiopoietin-2; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine