Anticancer activity of opened arene ruthenium metalla-assemblies.
Cationic tetranuclear and hexanuclear opened metalla-assemblies incorporating 5,15-bis(4-pyridyl)-10,20-diphenylporphyrin (bpp) or 5,10,15-tris(4-pyridyl)-20-phenylporphyrin (tpp) panels and dinuclear arene ruthenium clips [(p-cymene)(2)Ru(2)(OO[intersection]OO)(2)](2+) (OO[intersection]OO = oxalato, 2,5-dioxydo-1,4-benzoquinonato (dobq)) have been assembled in the presence of silver triflate. All complexes were characterised by NMR, IR and UV-visible spectroscopy and electrospray ionisation mass spectrometry. The cytotoxicities of the tetranuclear and hexanuclear ruthenium complexes have been established on ovarian A2780 and A2780cisR cancer cell lines. The compounds are quite cytotoxic, the most active metalla-assembly being [Ru(6)(p-cymene)(6)(dobq)(3)(tpp)(2)](6+), with IC(50) values of 2.1 microM and 3.8 microM against A2780 and A2780cisR cells, respectively.
Barry
Nicolas P E
NP
Institute of Chemistry, University of Neuchatel, 51 Ave de Bellevaux, CH-2000, Neuchatel, Switzerland.
Zava
Olivier
O
Furrer
Julien
J
Dyson
Paul J
PJ
Therrien
Bruno
B
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008698:Mesylates / Q000737:chemistry; D008968:Molecular Conformation; D011166:Porphyrins / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008698:Mesylates; D011166:Porphyrins; D012428:Ruthenium; C012077:trifluoromethanesulfonic acid