Effector and memory CD8+ T cell differentiation: toward a molecular understanding of fate determination.
CD8(+) T cells play a key role in protecting the body against invading microorganisms. Their capacity to control infection relies on the development of peripheral effector and memory T cells. Much of our current knowledge has been gained by tracking alterations of the phenotype of CD8(+) T cells but the molecular understanding of the events that underpin the emergence of heterogeneous effector and memory CD8(+) T cells in response to infection has remained limited. This review focuses on the recent progress in our understanding of the molecular wiring of this differentiation process.
Belz
Gabrielle T
GT
Division of Immunology, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. belz@wehi.edu.au
Kallies
Axel
A
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D007156:Immunologic Memory; D007378:Interleukins / Q000235:genetics / Q000378:metabolism; D051379:Mice; D015398:Signal Transduction; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
D007378:Interleukins; D014157:Transcription Factors