Anti-inflammatory and analgesic activities of methanolic extract of Kigelia pinnata DC flower.
BACKGROUND
Kigelia pinnata DC is extensively used in Indian traditional medicine for several diseases including inflammatory and painful disorders.


OBJECTIVE
The aim of the present study is to investigate the possible anti-inflammatory and analgesic activities of methanolic extract of Kigelia pinnata flower (MKFL) to support the medicinal uses claimed by folklore practitioners.


METHODS
MKFL is evaluated for its anti-inflammatory activity in carrageenan-induced paw edema model in rats and analgesic activity in acetic acid-induced writhing, hot plate and formalin-induced paw licking models in mice.


RESULTS
MKFL exhibited a significant (P<0.01) anti-inflammatory and analgesic activities with the doses of 100, 200 and 400mg/kg b.w. in rats and mice respectively.


CONCLUSIONS
The results of the experimental study thus strongly support the traditional use of this plant for inflammatory and pain disorders.
William Carey
M
M
Department of Pharmacognosy and Ethnopharmacology, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India. carey apti@yahoo.co.in
Rao
N Venkat
NV
Kumar
B Ravi
BR
Mohan
G Krishna
GK
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D029402:Bignoniaceae / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D000432:Methanol / Q000737:chemistry*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D000432:Methanol