Successful treatment of thyroid storm with plasmapheresis in a patient with methimazole-induced agranulocytosis.
OBJECTIVE
To report a case of a patient with Graves disease presenting with agranulocytosis induced by methimazole, with subsequent thyroid storm and successful therapeutic use of plasmapheresis.


METHODS
The clinical features and laboratory findings in a patient with agranulocytosis and thyroid storm are presented, and the available literature on utilization of plasmapheresis in the setting of thyrotoxicosis is reviewed.


RESULTS
A 40-year-old Vietnamese woman with Graves disease was admitted with methimazole-induced agranulocytosis. Treatment with methimazole was discontinued, and therapy with antibiotics, granulocyte colony-stimulating factor, and ibuprofen was initiated. During hospitalization of the patient, her clinical status deteriorated, with development of pericarditis, thrombocytopenia, and thyroid storm. Treatment with plasmapheresis yielded near-euthyroidism in 3 days. Subsequently, she underwent successful total thyroidectomy.


CONCLUSIONS
Our case highlights the effectiveness of plasmapheresis when clinical situations prohibit the use of traditional treatment methods for thyrotoxicosis or thyroid storm (or both).
Vyas
Ashish A
AA
Department of Medicine, Saint Vincent Hospital, Worcester, Massachusetts, USA.
Vyas
Priyanka
P
Fillipon
Nicole Lynn
NL
Vijayakrishnan
Rajakrishnan
R
Trivedi
Nitin
N
D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced / Q000150:complications* / Q000276:immunology; D013956:Antithyroid Agents / Q000009:adverse effects*; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008713:Methimazole / Q000009:adverse effects*; D010956:Plasmapheresis; D013958:Thyroid Crisis / Q000150:complications* / Q000276:immunology / Q000601:surgery / Q000628:therapy*; D013965:Thyroidectomy; D013971:Thyrotoxicosis / Q000276:immunology / Q000628:therapy; D016896:Treatment Outcome
D013956:Antithyroid Agents; D008713:Methimazole