title: Synthesis and antimicrobial activity of new 4-heteroarylamino coumarin derivatives containing nitrogen and sulfur as heteroatoms.
abstract: Synthesis, spectral analysis and bioactivity of new coumarin derivatives are described in this paper. Eight new coumarin derivatives were synthesized in moderate to good yields by condensation of 4-chloro-3-nitrocoumarin and the corresponding heteroarylamine. The synthesized compounds were tested for their in vitro antimicrobial activity, in a standard disk diffusion assay, against thirteen strains of bacteria and three fungal strains. They have shown a wide range of activity - from one completely inactive compound to medium active ones.
authors.affiliation: Department of Chemistry, Faculty of Science and Mathematics, University of Pristina, Lole Ribara 29, Kosovska Mitrovica, Serbia.
authors.forename: Biljana R
authors.initials: BR
authors.lastname: Dekić
authors.forename: Niko S
authors.initials: NS
authors.lastname: Radulović
authors.forename: Vidoslav S
authors.initials: VS
authors.lastname: Dekić
authors.forename: Rastko D
authors.initials: RD
authors.lastname: Vukićević
authors.forename: Radosav M
authors.initials: RM
authors.lastname: Palić
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D009584:Nitrogen / Q000737:chemistry; D013455:Sulfur / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003374:Coumarins; D013455:Sulfur; D009584:Nitrogen