title: Chronic femoral artery occlusion augments exercise pressor reflex in decerebrated rats.
abstract: In decerebrated rats, we determined the pressor and cardioaccelerator reflex responses to static contraction of hindlimb muscles whose femoral arteries were either occluded 72 h before contraction, occluded 3 min before contraction, or freely perfused. We found that the pressor reflex arising from the limb whose femoral artery was occluded for 72 h before contraction (32 +/- 5 mmHg, n = 16) was significantly higher than the pressor reflex arising from the contralateral freely perfused limb (15 +/- 3 mmHg, n = 16, P < 0.001) or than that arising from the contralateral limb whose femoral artery was occluded for only 3 min (17 +/- 4 mmHg, n = 16, P < 0.001). Moreover, the pressor reflex arising from the limb whose femoral artery was occluded for 3 min before the start of contraction was not significantly different than that arising from the contralateral freely perfused limb (n = 16, P = 0.819). The pressor component of the reflex arising from the limb whose femoral artery was occluded for 72 h was not changed by transient receptor potential vanilloid (TRPV) 1 receptor blockade with iodo-resiniferatoxin (n = 15, P = 0.272), although the cardioaccelerator component was significantly reduced (P = 0.005). In addition, the pressor response evoked by capsaicin injection in the femoral artery of the 72-h occluded limb was more than double that evoked from the freely perfused limb (P = 0.026). We conclude that chronic (i.e., 72 h) but not acute (3 min), femoral arterial occlusion augments pressor reflex arising from contraction of hindlimb muscles and that TRPV1 receptors play little role in this augmentation.
authors.affiliation: Penn State Heart and Vascular Institute, Pennsylvania State University College of Medicine, 500 University Drive, Hershey Medical Center, Hershey, PA 17033, USA.
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Tsuchimochi
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: McCord
authors.forename: Shawn G
authors.initials: SG
authors.lastname: Hayes
authors.forename: Satoshi
authors.initials: S
authors.lastname: Koba
authors.forename: Marc P
authors.initials: MP
authors.lastname: Kaufman
mesh_terms: D000818:Animals; D001157:Arterial Occlusive Diseases / Q000378:metabolism / Q000503:physiopathology*; D017704:Baroreflex / Q000187:drug effects; D001794:Blood Pressure; D002211:Capsaicin / Q000494:pharmacology; D002908:Chronic Disease; D003251:Constriction, Pathologic; D003655:Decerebrate State; D004195:Disease Models, Animal; D004224:Diterpenes / Q000494:pharmacology; D005263:Femoral Artery / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery; D006339:Heart Rate; D006614:Hindlimb; D007511:Ischemia / Q000378:metabolism / Q000503:physiopathology*; D008026:Ligation; D008297:Male; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000098:blood supply*; D005082:Physical Exertion; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow; D018689:Sensory System Agents / Q000494:pharmacology; D050916:TRPV Cation Channels / Q000037:antagonists & inhibitors / Q000378:metabolism; D013997:Time Factors
chemical_list: D004224:Diterpenes; D018689:Sensory System Agents; D050916:TRPV Cation Channels; C493922:Trpv1 protein, rat; C468130:iodoresiniferatoxin; D002211:Capsaicin