Biological roles of Acid and neutral sphingomyelinases and their regulation by nitric oxide.
Generation of the pleiotropic sphingolipid mediator ceramide by acid and neutral sphingomyelinases is a key event in many cellular pathophysiological processes including survival, death, proliferation, and differentiation, in which also the short-lived gaseous messenger nitric oxide plays a crucial role. This review describes how the outcome of these key cellular processes is finely tuned by surprising and complex interplays among nitric oxide, ceramide, and their effectors.
Perrotta
Cristiana
C
Unit of Clinical Pharmacology, Department of Preclinical Sciences, University Hospital Luigi Sacco, Università di Milano, Milano, Italy.
Clementi
Emilio
E
D000818:Animals; D004789:Enzyme Activation / Q000502:physiology*; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism*
D009569:Nitric Oxide; D013108:Sphingomyelin Phosphodiesterase