title: [Epigenetic mechanism of RUNX1 in pathogenesis of leukemia].
abstract: RUNX1, also called AML1, is a member of RUNX transcriptional factor family, and also is the most frequent target for chromosomal translocations in leukemia. RUNX1 is a very important transcription factor, can enhance or repress the expressions of many hematopoiesis related genes. RUNX1 may receive a series of post-translational modifications, and the activity of RUNX1 can be affected by these post-translational modifications, thus RUNX1 regulates the differentiation, apoptosis and self-renewal of hematopoietic cells. This article reviews the role of RUNX1 in the pathogenesis of leukemia mainly including its target genes, transcriptional mechanism and post-translational modifications.
authors.affiliation: Hematological Center, Beijing Children Hospital, Capital Medical University, Beijing 100045, China.
authors.forename: Han
authors.initials: H
authors.lastname: Zhang
authors.forename: Hu-Yong
authors.initials: HY
authors.lastname: Zheng
mesh_terms: D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics*; D044127:Epigenesis, Genetic; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000378:metabolism; D011499:Protein Processing, Post-Translational
chemical_list: D050676:Core Binding Factor Alpha 2 Subunit