title: Clinical considerations in face transplantation.
abstract: Severe facial burns cause significant deformities that are technically challenging to treat. Conventional treatments almost always result in poor aesthetic and functional outcomes. This is due to the fact that current treatments cover or replace the delicate anatomical facial tissues with autologus grafts and flaps from remote sites. The recent introduction of clinical composite tissue allotransplantation (CTA) that uses healthy facial tissue transplanted from donors to reconstruct the damaged or non-existing facial tissues with original tissues makes it possible to achieve the best possible functional and aesthetic outcomes in these challenging injuries. The techniques required to perform this procedure, while technically challenging, have been developed over many years and are used routinely in reconstructive surgery. The immunosuppressive regimens necessary to prevent transplanted facial tissue from rejecting (tacrolimus/mycophenolate mofetil/steroid) were developed for and have been used successfully in solid organ transplants for many years. The psychosocial and ethical issues associated with this new treatment have some nuances but generally have many similarities with solid organ and more recently hand transplantation, both of which have been performed clinically for 40 and 10+ years respectively. Herein, we will discuss the technical and immunological aspects of facial tissue transplantation. The psychosocial and ethical issues will be discussed separately in another article in this issue.
authors.affiliation: Department of Surgery, University of Louisville, KY, USA.
authors.forename: Sathnur B
authors.initials: SB
authors.lastname: Pushpakumar
authors.forename: John H
authors.initials: JH
authors.lastname: Barker
authors.forename: Chirag V
authors.initials: CV
authors.lastname: Soni
authors.forename: Hazel
authors.initials: H
authors.lastname: Joseph
authors.forename: Vera C
authors.initials: VC
authors.lastname: van Aalst
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Banis
authors.forename: Johannes
authors.initials: J
authors.lastname: Frank
mesh_terms: D002056:Burns / Q000601:surgery*; D054445:Facial Transplantation / Q000379:methods*; D006084:Graft Rejection; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D018579:Patient Selection; D019651:Plastic Surgery Procedures / Q000379:methods*; D016038:Skin Transplantation / Q000379:methods; D009927:Tissue and Organ Procurement; D014184:Transplantation, Homologous
chemical_list: D007166:Immunosuppressive Agents