title: [Short-term therapeutic effect and safety of endostar combined with XELIRI regimen in the treatment of advanced colorectal cancer].
abstract: OBJECTIVE
  To evaluate the short-term efficacy and toxicity of endostar in combination with XELIRI as the second-line treatment for advanced colorectal cancer.
  
  
  METHODS
  Twenty-one patients with advanced colorectal cancer were treated with intravenous infusion of endostar (15 mg/day for 14 consecutive days) and irinotecan (250 mg/m(2), single dose on the first day), and oral administration of capecitabine (1.0 mg/m(2), twice daily for 14 days), and the treatment cycle was repeated every 21 days. The efficacy and toxicity of the treatments were evaluated according to RECIST and NCI-CTCAE3.0 standard, respectively.
  
  
  RESULTS
  The overall response rate was 9.5% in these patients, with a median time to progression (mTTP) of 3.9 months. The main adverse effects associated with the treatment included leucopenia, nausea/vomiting and peripheral neuritis.
  
  
  CONCLUSIONS
  Endostar combined with XELIRI is effective and safe as the second-line treatment for advanced colorectal cancer, and further clinical investigation is warranted.
authors.affiliation: Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. liaowj@fimmu.com
authors.forename: Wang-jun
authors.initials: WJ
authors.lastname: Liao
authors.forename: Peng
authors.initials: P
authors.lastname: Shen
authors.forename: Wen yun
authors.initials: Wy
authors.lastname: Wu
authors.forename: Min
authors.initials: M
authors.lastname: Shi
authors.forename: Rong-cheng
authors.initials: RC
authors.lastname: Luo
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D000069287:Capecitabine; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000556:secondary; D003841:Deoxycytidine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D043169:Endostatins / Q000008:administration & dosage* / Q000009:adverse effects / Q000235:genetics; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D006801:Humans; D000077146:Irinotecan; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects
chemical_list: D043169:Endostatins; D011994:Recombinant Proteins; D003841:Deoxycytidine; D000069287:Capecitabine; D000077146:Irinotecan; C522911:endostar protein; D005472:Fluorouracil; D002166:Camptothecin