title: Serum resistin concentrations in children with Kawasaki disease.
abstract: OBJECTIVE
  Human resistin is expressed strongly in monocytes or macrophages rather than in adipocytes and may play a pivotal role in inflammation. We hypothesize that resistin levels are elevated in patients with Kawasaki disease (KD) in the acute phase and may be associated with the disease severity.
  
  
  METHODS
  Serum resistin concentrations were measured in 44 Japanese children with KD and 17 age-matched healthy children. All the KD patients were given both aspirin and a single dose of intravenous immunoglobulin (IVIG).
  
  
  RESULTS
  The serum resistin levels at baseline in KD children were significantly higher than those in controls [33.0 (21.6-45.3) vs. 14.8 (12.4-18.6) ng/mL, P < 0.001]. After IVIG therapy, serum resistin levels were significantly decreased to normal control levels. No significant difference in baseline resistin levels was found between the high-risk group and the low-risk group of coronary artery aneurysms.
  
  
  CONCLUSIONS
  We confirmed that resistin was an acute inflammatory protein, but its concentrations were unlikely to predict the prognosis of disease in acute KD patients.
authors.affiliation: Department of Pediatrics, Tsukuba Medical Center Hospital, Tsukuba, Ibaraki, Japan. nozueh@xd5.so-net.ne.jp
authors.forename: Hiroki
authors.initials: H
authors.lastname: Nozue
authors.forename: Hironori
authors.initials: H
authors.lastname: Imai
authors.forename: Hisako
authors.initials: H
authors.lastname: Saitoh
authors.forename: Takeshi
authors.initials: T
authors.lastname: Aoki
authors.forename: Kunio
authors.initials: K
authors.lastname: Ichikawa
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Kamoda
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007223:Infant; D007564:Japan; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D052243:Resistin / Q000097:blood*
chemical_list: D016756:Immunoglobulins, Intravenous; C499624:RETN protein, human; D052243:Resistin