Perspectives of liquid chromatography coupled to low- and high-resolution mass spectrometry for screening, identification, and quantification of drugs in clinical and forensic toxicology.
This article reviews papers on the use of liquid chromatography coupled to low- and high-resolution mass spectrometry in clinical and forensic toxicology. They cover procedures for target and for more comprehensive screening for drugs (of abuse), identification of drug metabolites, and multianalyte procedures for quantification of drugs and/or their metabolites in body samples. Besides a critical overview, perspectives are discussed.
Maurer
Hans H
HH
Department of Experimental and Clinical Toxicology, Saarland University, Homburg, Germany. hans.maurer@uks.eu
D002853:Chromatography, Liquid / Q000379:methods; D053593:Forensic Toxicology / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000302:isolation & purification / Q000652:urine; D011042:Poisons / Q000302:isolation & purification / Q000633:toxicity / Q000652:urine; D015813:Substance Abuse Detection
D004364:Pharmaceutical Preparations; D011042:Poisons