Pharmacoepigenetics in heart failure.
Epigenetics studies inheritable changes of genes and gene expression that do not concern DNA nucleotide variation. Such modifications include DNA methylation, several forms of histone modification, and microRNAs. From recent studies, we know not only that genetic changes account for heritable phenotypic variation, but that epigenetic changes also play an important role in the variation of predisposition to disease and to drug response. In this review, we discuss recent evidence of epigenetic changes that play an important role in the development of cardiac hypertrophy and heart failure and may dictate response to therapy.
Mateo Leach
Irene
I
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700RB Groningen, The Netherlands. i.v.mateo.leach@thorax.umcg.nl
van der Harst
Pim
P
de Boer
Rudolf A
RA
D019175:DNA Methylation; D044127:Epigenesis, Genetic; D020022:Genetic Predisposition to Disease; D006333:Heart Failure / Q000235:genetics*; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D010597:Pharmacogenetics
D035683:MicroRNAs