Immunolocalization of NK-1 receptor and Substance P in human normal placenta.
A role for Substance P (SP) in human placenta is not known, although is possible that regulates placental physiology through the Neurokinin (NK)-1 receptor. Ten human normal placenta tissues were studied by immunohistochemistry to demonstrate the localization of NK-1 receptor and SP. An immunostaining pattern for NK-1 receptor and SP was observed in the endothelium and myocytes of fetal blood vessels, decidua and trophoblast. The SP is located in both the cytoplasm and the nucleus whereas NK-1 receptor in cytoplasmic. These findings reported here for the fist time, suggest a role for the SP and NK-1 receptor in the placental physiology.
Muñoz
M
M
Research Laboratory on Neuropeptides, Virgen del Rocío University Children's Hospital, Sevilla, Spain. mmunoz@cica.es
Pavón
A
A
Rosso
M
M
Salinas
M V
MV
Pérez
A
A
Carranza
A
A
González-Ortega
A
A
D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D003656:Decidua / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D018040:Receptors, Neurokinin-1 / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*; D014327:Trophoblasts / Q000378:metabolism
D018040:Receptors, Neurokinin-1; D013373:Substance P