title: Bilateral ureteric obstruction secondary to renal papillary necrosis.
abstract: A 2-year-old male presented to hospital with a 5-day history of vomiting and pyrexia. He was initially treated with non-steroidal medication as an anti-pyretic. Initial investigations demonstrated a raised urea and creatinine and he was treated with intravenous fluids. Within 24 h he became anuric with progressive renal insufficiency. Ultrasound scan demonstrated minimal bilateral hydronephrosis with debris in the lower pole calyces. The bladder was empty. Cystoscopy and retrograde contrast imaging revealed bilateral ureteric obstruction. Double J stents were inserted and his renal function returned to normal within 4 days. We believe the aetiology to be renal papillary necrosis and bilateral ureteric obstruction secondary to the administration of ibuprofen in association with dehydration.
authors.affiliation: Royal Hospital for Sick Children, Glasgow, UK. EBroadis@doctors.org.uk
authors.forename: Emily
authors.initials: E
authors.lastname: Broadis
authors.forename: Louise
authors.initials: L
authors.lastname: Barbour
authors.forename: Stuart
authors.initials: S
authors.lastname: O'Toole
authors.forename: Alasdair
authors.initials: A
authors.lastname: Fyfe
authors.forename: Martyn
authors.initials: M
authors.lastname: Flett
authors.forename: Greg
authors.initials: G
authors.lastname: Irwin
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Ramage
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D003681:Dehydration / Q000150:complications; D003937:Diagnosis, Differential; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects; D007223:Infant; D007681:Kidney Papillary Necrosis / Q000150:complications* / Q000175:diagnosis / Q000601:surgery*; D008297:Male; D014517:Ureteral Obstruction / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen