title: Treatment of premature ovarian failure trial: description of an ongoing clinical trial.
abstract: Premature ovarian failure is a relatively common clinical condition, and carries important long-term health consequences. Estrogen replacement is recommended to alleviate unpleasant hypo-estrogenic symptoms and reduce long-term health risks. However, the most suitable form of estrogen replacement, and the exact effects of no treatment, is unknown. Surprisingly, little research has been carried out in this area. We describe the design of an ongoing clinical trial that will address these issues so that we can begin to provide evidence-based care for affected women.
authors.affiliation: Menopause Research Unit, McNair Centre, Ground Floor Southwark Wing, Guy's Hospital, London SE1 9RT, UK. beth.cartwright@kcl.ac.uk
authors.forename: Beth
authors.initials: B
authors.lastname: Cartwright
authors.forename: Jillian
authors.initials: J
authors.lastname: Robinson
authors.forename: Janice
authors.initials: J
authors.lastname: Rymer
mesh_terms: D000293:Adolescent; D000328:Adult; D015519:Bone Density; D003277:Contraceptives, Oral, Combined / Q000627:therapeutic use*; D003280:Contraceptives, Oral, Synthetic / Q000627:therapeutic use*; D004338:Drug Combinations; D004958:Estradiol / Q000008:administration & dosage; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000008:administration & dosage; D004997:Ethinyl Estradiol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000008:administration & dosage / Q000627:therapeutic use*; D016649:Primary Ovarian Insufficiency / Q000175:diagnosis / Q000628:therapy*; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003277:Contraceptives, Oral, Combined; D003280:Contraceptives, Oral, Synthetic; D004338:Drug Combinations; D004967:Estrogens; C072593:ethinyl estradiol, levonorgestrel drug combination; D004997:Ethinyl Estradiol; D004958:Estradiol; D016912:Levonorgestrel