Modulation of pressure-natriuresis by renal medullary reactive oxygen species and nitric oxide.
The renal pressure-natriuresis mechanism is the dominant controller of body fluid balance and long-term arterial pressure. In recent years, it has become clear that the balance of reactive oxygen and nitrogen species within the renal medullary region is a key determinant of the set point of the renal pressure-natriuresis curve. The development of renal medullary oxidative stress causes dysfunction of the pressure-natriuresis mechanism and contributes to the development of hypertension in numerous disease models. The purpose of this review is to point out the known mechanisms within the renal medulla through which reactive oxygen and nitrogen species modulate the pressure-natriuresis response and to update the reader on recent advances in this field.
O'Connor
Paul M
PM
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53202, USA. poconnor@mcw.edu
Cowley
Allen W
AW
D001794:Blood Pressure / Q000502:physiology*; D004231:Diuresis; D016232:Endothelins; D004730:Endothelium, Vascular / Q000201:enzymology; D045462:Endothelium-Dependent Relaxing Factors; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D007679:Kidney Medulla / Q000473:pathology*; D009318:Natriuresis; D009569:Nitric Oxide / Q000096:biosynthesis / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D012982:Sodium, Dietary; D013481:Superoxides; D014882:Water-Electrolyte Balance / Q000187:drug effects / Q000502:physiology*
D016232:Endothelins; D045462:Endothelium-Dependent Relaxing Factors; D017382:Reactive Oxygen Species; D012982:Sodium, Dietary; D013481:Superoxides; D009569:Nitric Oxide; D006861:Hydrogen Peroxide; D019001:Nitric Oxide Synthase