title: Morita-Baylis-Hillman reaction of lactams and lactones with alkyl halides and epoxides catalyzed by hydroxysulfides.
abstract: A new Morita-Baylis-Hillman reaction methodology in which alkyl halides and epoxides act as electrophiles in their reaction with lactones and lactams is shown. Catalysis is efficiently performed by hydroxy sulfides under basic conditions. The procedure works efficiently with many alkyl halides but fails with aldehydes with which a conventional acid-catalyzed procedure is used.
authors.affiliation: Facultad de Farmacia, Dpto. Química, Universidad San Pablo CEU, Urb. Montepríncipe, ctra. Boadilla km 5, 300 Boadilla del Monte, 28668 Madrid, Spain.
authors.forename: Irene
authors.initials: I
authors.lastname: Suarez del Villar
authors.forename: Ana
authors.initials: A
authors.lastname: Gradillas
authors.forename: Gema
authors.initials: G
authors.lastname: Domínguez
authors.forename: Javier
authors.initials: J
authors.lastname: Pérez-Castells
mesh_terms: D002384:Catalysis; D004852:Epoxy Compounds / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D007769:Lactams / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013440:Sulfides / Q000737:chemistry*
chemical_list: D004852:Epoxy Compounds; D006846:Hydrocarbons, Halogenated; D007769:Lactams; D007783:Lactones; D013440:Sulfides