title: Evaluation of analgesic and anti-inflammatory potential of Hedyotis puberula (G. Don) R. Br. ex Arn. in experimental animal models.
abstract: Hedyotis puberula (G. Don) R. Br. ex Arn. is used for the treatment of several ailments in the traditional system of medicine. In the present study, the methanol extract of the whole plant (200 and 400 mg/kg) exhibited significant analgesic and anti-inflammatory activities in a dose dependent manner. The analgesic effect, evaluated in mice in hot plate as well as acetic acid-induced writhings, were higher than the standard drugs pentazocine (30 mg/kg) and indomethacin (5 mg/kg), respectively. Further, the methanol extract at the dose of 400mg/kg produced significant inhibition of carrageenan induced paw edema and reduced the weight of granuloma in cotton pellet-induced granuloma pouch model.
authors.affiliation: Department of Botany, School of Life Sciences, Bharathiar University, Coimbatore, Tamil Nadu 641046, India.
authors.forename: Jince Mary
authors.initials: JM
authors.lastname: Joseph
authors.forename: Kandhasamy
authors.initials: K
authors.lastname: Sowndhararajan
authors.forename: Sellamuthu
authors.initials: S
authors.lastname: Manian
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002351:Carrageenan; D032561:Cotton Fiber; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D032064:Hedyotis / Q000737:chemistry* / Q000633:toxicity; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000502:physiology
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D002351:Carrageenan; D019342:Acetic Acid