Effects of meloxicam on reproduction parameters in dairy cattle.
This study was carried out in dairy cattle with the NSAID meloxicam to investigate possible drug effects on different reproductive parameters as well as on the progeny. Forty-one cows received intravenous injection of either meloxicam (Metacam 20 mg/mL solution for injection) or placebo at a dose volume of 7.5 mL/100 kg, corresponding to a dose of 1.5 mg meloxicam/kg, i.e. three times the recommended therapeutic dose. Treatment was performed in each phase of reproduction, i.e. once prior to breeding, twice shortly after breeding, once at the beginning of the second and third trimester of gestation and once at the end of the third trimester of gestation. Offspring of the cows were weighed and clinically examined for vitality at birth and after 28 days. No relevant difference between the meloxicam and control group was found in the reproductive performance of the cows or in the body weight development or vitality of the calves.
Hirsch
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Boehringer Ingelheim Animal Health GmbH, Ingelheim/Rhein, Germany. alexandra.hirsch@ing.boehringer-ingelheim.com
Philipp
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D000034:Abortion, Veterinary; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001724:Birth Weight / Q000187:drug effects; D002417:Cattle; D003612:Dairying; D005260:Female; D000077239:Meloxicam; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000662:veterinary; D013843:Thiazines / Q000494:pharmacology*; D013844:Thiazoles / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013843:Thiazines; D013844:Thiazoles; D000077239:Meloxicam