title: Lung transplantation with donation after cardiac death donors: long-term follow-up in a single center.
abstract: OBJECTIVE
  We sought to examine long-term outcomes at the University of Wisconsin for all lung transplant recipients who received lungs from donation after cardiac death donors since the initiation of this program in 1993.
  
  
  METHODS
  Eighteen (4.2%) of the 424 lung transplantations performed in 406 patients between January 1993 and April 2009 used lungs from donation after cardiac death donors. Outcomes for this recipient cohort were compared with those for recipients who received organs from brain-dead donors.
  
  
  RESULTS
  Warm ischemic time (from withdrawal of support to reperfusion of organs) was 30 +/- 17 minutes (11-93 minutes). The patient survival rates in the donation after cardiac death group (DCD group) at 1, 3, and 5 years were 88.1% +/- 7.9%, 81.9% +/- 9.5%, and 81.9% +/- 9.5%, respectively. These survival rates were not different from those of the brain-dead donor group (BDD group, P = .66). The incidence of primary graft dysfunction in the DCD group was similar to that of the BDD group (P = .59). However, the incidence of airway complications was somewhat higher in the DCD group. Freedom from bronchiolitis obliterans syndrome at 1, 3, and 5 years in the DCD group was 80.4% +/- 10.2%, 80.4% +/- 10.2%, and 72.3% +/- 11.9%, respectively, and did not differ from the incidence of bronchiolitis obliterans syndrome in the BDD group (P = .59).
  
  
  CONCLUSIONS
  Our data show that the long-term patient and graft survival rates after donation after cardiac death lung transplantation were equivalent to those after brain-dead donor lung transplantation. Our findings suggest that the use of donation after cardiac death donors can safely and substantially expand the donor pool for lung transplantation.
authors.affiliation: Department of Surgery, Division of Cardiothoracic Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wis., USA. deoliveira@surgery.wisc.edu
authors.forename: Nilto C
authors.initials: NC
authors.lastname: De Oliveira
authors.forename: Satoru
authors.initials: S
authors.lastname: Osaki
authors.forename: James D
authors.initials: JD
authors.lastname: Maloney
authors.forename: Keith C
authors.initials: KC
authors.lastname: Meyer
authors.forename: Takushi
authors.initials: T
authors.lastname: Kohmoto
authors.forename: Anthony M
authors.initials: AM
authors.lastname: D'Alessandro
authors.forename: Robert B
authors.initials: RB
authors.lastname: Love
mesh_terms: D000328:Adult; D001989:Bronchiolitis Obliterans / Q000209:etiology; D016009:Chi-Square Distribution; D003643:Death; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D053208:Kaplan-Meier Estimate; D016040:Lung Transplantation / Q000009:adverse effects / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D055031:Primary Graft Dysfunction / Q000209:etiology; D015397:Program Evaluation; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors / Q000600:supply & distribution*; D016896:Treatment Outcome; D052096:Warm Ischemia; D014922:Wisconsin