Multiple unrelated chromosomal abnormalities in host cells after cord blood transplantation.
We experienced a 16-year-old patient with T-cell acute lymphoblastic leukemia, who had multiple unrelated chromosomal abnormalities in host cells after chemotherapy and cord blood transplantation (CBT). In 7 consecutive cytogenetic studies after CBT, he showed various chromosomal abnormalities including t(1;11)(p32;q23), t(8;21)(q22.2;q22.2), t(6;10)(p21.3;q26), and del(7) (q22q34). His chromosomal abnormalities were unstable and different in each cytogenetic study except del(7)(q22q34). He had neither anemia nor leukopenia, and his thrombocytopenia continuously improved after CBT. He was clinically stable for 2.5 years despite his complex chromosomal abnormalities. The clinical relevance of genetic instabilities in host cells after CBT is unclear, and long-term monitoring with additional cases is needed.
Moon
HeeWon
H
Department of Laboratory Medicine, Konkuk University School of Medicine, Seoul, Korea.
Cho
JinHee
J
Hur
Mina
M
Yun
Yeo-Min
YM
Han
Sung-Hee
SH
Lee
Mark Hong
MH
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002869:Chromosome Aberrations; D036101:Cord Blood Stem Cell Transplantation; D006801:Humans; D008297:Male; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000628:therapy*; D012074:Remission Induction