New drugs for neglected infectious diseases: Chagas' disease.
Chagas' disease (CD) is caused by the protozoan Trypanosoma cruzi (Tc) and remains an important cause of morbidity and mortality. Most researchers in the field now agree that chronic low grade parasite persistence in tissue drives tissue damage and the autoimmune component of CD. Current therapy relies on two compounds: benznidazole and nifurtimox. Despite their long history in the treatment of CD, both compounds induce significant side-effects. In the current issue of the BJP, two contributions demonstrate that NO-donors are active, especially in combination with benznidazole, against Tc in vitro and in experimental models in vivo. The basic concept used by the authors to develop novel anti-Tc compounds relied on the demonstrated ability of nitric oxide to kill the parasite. There are several issues still to be resolved but the reported studies are a clear advance to the field and should be considered for further pre-clinical development.
Machado
Fabiana S
FS
Department of Biochemistry and Immunology, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Tanowitz
Herbert B
HB
Teixeira
Mauro M
MM
D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy* / Q000401:mortality / Q000469:parasitology; D006801:Humans; D009547:Nifurtimox / Q000009:adverse effects / Q000494:pharmacology; D020030:Nitric Oxide Donors / Q000494:pharmacology; D009593:Nitroimidazoles / Q000009:adverse effects / Q000494:pharmacology; D014344:Trypanocidal Agents / Q000009:adverse effects / Q000494:pharmacology*; D014349:Trypanosoma cruzi / Q000187:drug effects*
D020030:Nitric Oxide Donors; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; D009547:Nifurtimox; C009999:benzonidazole