title: New dirhodium complex with activity towards colorectal cancer.
abstract: A novel dirhodium complex (Rh(2)(L-PheAla)(2)(OAc)(2) is reported with strong activity towards human colon adenocarcinoma cells. Its effect was not accompanied by generation of reactive oxygen species (ROS) neither by activation of caspase-3.
authors.affiliation: CQFM-Centro de Química-Física Molecular and IN-Institute of Nanosciences and Nanotechnology, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal. raquel.frade@ist.utl.pt
authors.forename: Raquel F M
authors.initials: RF
authors.lastname: Frade
authors.forename: Nuno R
authors.initials: NR
authors.lastname: Candeias
authors.forename: Catarina M M
authors.initials: CM
authors.lastname: Duarte
authors.forename: Vânia
authors.initials: V
authors.lastname: André
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Duarte
authors.forename: Pedro M P
authors.initials: PM
authors.lastname: Gois
authors.forename: Carlos A M
authors.initials: CA
authors.lastname: Afonso
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D053148:Caspase 3 / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D004789:Enzyme Activation; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism; D012238:Rhodium / Q000494:pharmacology*
chemical_list: D017382:Reactive Oxygen Species; D012238:Rhodium; D053148:Caspase 3