title: Partially hydrolyzed 100% whey protein infant formula and atopic dermatitis risk reduction: a systematic review of the literature.
abstract: The incidence of atopic dermatitis (AD) is increasing worldwide. Clinical studies have observed reduced risks of AD among infants fed with 100% whey partially hydrolyzed infant formula (PHF-W) compared with intact protein cow's milk formula. To evaluate this potential relationship more comprehensively, a systematic review of the literature was conducted. Studies (n = 18, representing 12 distinct study populations) that specified the protein source of the formula, evaluated healthy-term infants, compared the use of PHF-W with intact protein cow's milk formula, and reported results for AD were included. A critical assessment of the methodological quality of studies was conducted. In all studies, a reduced incidence of AD and/or atopic manifestations that included AD was observed. The cumulative incidence of AD was significantly lower among infants over at least 3 years of follow-up in the PHF-W group compared with the intact protein cow's milk group. Exclusive breastfeeding should be encouraged as the primary means to prevent atopic risk. However, when infants are not exclusively breastfed, PHF-W may be considered an effective measure to potentially reduce the risk of developing AD.
authors.affiliation: Exponent Health Sciences Practice, Wood Dale, Illinois 60191, USA. dalexander@exponent.com
authors.forename: Dominik D
authors.initials: DD
authors.lastname: Alexander
authors.forename: Donald F
authors.initials: DF
authors.lastname: Schmitt
authors.forename: Nga L
authors.initials: NL
authors.lastname: Tran
authors.forename: Leila M
authors.initials: LM
authors.lastname: Barraj
authors.forename: Colleen A
authors.initials: CA
authors.lastname: Cushing
mesh_terms: D001942:Breast Feeding; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000517:prevention & control*; D004044:Dietary Proteins / Q000008:administration & dosage*; D006801:Humans; D015994:Incidence; D007223:Infant; D041943:Infant Formula; D007231:Infant, Newborn; D008894:Milk Proteins / Q000008:administration & dosage*; D012307:Risk Factors; D000067816:Whey Proteins
chemical_list: D004044:Dietary Proteins; D008894:Milk Proteins; D000067816:Whey Proteins