title: The emerging role of iron dyshomeostasis in the mitochondrial decay of aging.
abstract: Recent studies show that cellular and mitochondrial iron increases with age. Iron overload, especially in mitochondria, increases the availability of redox-active iron, which may be a causal factor in the extensive age-related biomolecular oxidative damage observed in aged organisms. Such damage is thought to play a major role in the pathogenesis of iron overload diseases and age-related pathologies. Indeed, recent findings of the beneficial effects of iron manipulation in life extension in Caenorhabditis elegans, Drosophila and transgenic mice have sparked a renewed interest in the potential role of iron in longevity. A substantial research effort now focuses on developing and testing safe pharmacologic interventions to combat iron dyshomeostasis in aging, acute injuries and in iron overload disorders.
authors.affiliation: Department of Aging and Geriatrics Research, Division of Biology of Aging, Genomics, Metabolism and Biomarkers Core of the Institute on Aging, University of Florida, Gainesville, FL 32611, USA.
authors.forename: Jinze
authors.initials: J
authors.lastname: Xu
authors.forename: Emanuele
authors.initials: E
authors.lastname: Marzetti
authors.forename: Arnold Y
authors.initials: AY
authors.lastname: Seo
authors.forename: Jae-Sung
authors.initials: JS
authors.lastname: Kim
authors.forename: Tomas A
authors.initials: TA
authors.lastname: Prolla
authors.forename: Christiaan
authors.initials: C
authors.lastname: Leeuwenburgh
mesh_terms: D000367:Age Factors; D000375:Aging / Q000378:metabolism*; D000818:Animals; D016922:Cellular Senescence; D006706:Homeostasis; D006801:Humans; D007501:Iron / Q000378:metabolism*; D019190:Iron Overload / Q000378:metabolism*; D008136:Longevity; D008928:Mitochondria / Q000378:metabolism*; D028361:Mitochondrial Diseases / Q000378:metabolism*; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D017382:Reactive Oxygen Species; D007501:Iron