Euprolactinemic galactorrhea associated with use of imipramine and escitalopram in a postmenopausal woman.
Hormonal side effects of antidepressants are infrequent, and galactorrhea is seldom mentioned among tricyclic antidepressant (TCA) and selective serotonin reuptake inhibitor (SSRI)-related side effects. Antidepressants can directly stimulate postsynaptic 5-HT receptors in the hypothalamus or indirectly inhibit the tuberoinfundibular dopaminergic neurons through 5-HT, which may increase prolactin levels and later cause galactorrhea. We describe a case of euprolactinemic galactorrhea in a postmenopausal woman, induced by imipramine and escitalopram. This report highlights the presence of unidentified novel mechanisms of antidepressant-induced galactorrhea and other possible contributors.
Mahasuar
Rajnarayan
R
Department of Psychiatry, Christian Medical College and Hospital, Vellore, Tamilnadu 632004, India. drrajnarayan@gmail.com
Majhi
Pratima
P
Ravan
Jayprakash Rusell
JR
D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects*; D015283:Citalopram / Q000009:adverse effects*; D005260:Female; D005687:Galactorrhea / Q000139:chemically induced*; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000139:chemically induced* / Q000150:complications; D007099:Imipramine / Q000009:adverse effects*; D008875:Middle Aged; D017698:Postmenopause / Q000523:psychology
D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D015283:Citalopram; D007099:Imipramine