The role of polyphenols in cardiovascular disease.
Epidemiological studies suggest that diets rich in polyphenols may be associated with reduced incidence of cardiovascular disorders (mainly coronary heart disease and myocardial infarction). However, the mechanisms explaining this correlation have not been fully elucidated. Current evidence suggests that polyphenols, acting at the molecular level, improve endothelial function and inhibit platelet aggregation. In view of their antithrombotic, anti-inflammatory, and anti-aggregative properties, these compounds may play a roles in the prevention and treatment of cardiovascular disease.
Michalska
Marta
M
Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Lodz, Poland.
Gluba
Anna
A
Mikhailidis
Dimitri P
DP
Nowak
Piotr
P
Bielecka-Dabrowa
Agata
A
Rysz
Jacek
J
Banach
Maciej
M
D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000517:prevention & control*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology; D005419:Flavonoids / Q000494:pharmacology*; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D010636:Phenols / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D059808:Polyphenols
D005419:Flavonoids; D010636:Phenols; D010975:Platelet Aggregation Inhibitors; D059808:Polyphenols