title: Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes.
abstract: Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of protein-coding gene expression, the transcription of noncoding RNA genes by RNA polymerase III (Pol III) is less well characterized. Here we profile the epigenetic features of Pol III target genes throughout the human genome. This reveals that the chromatin landscape of Pol III-transcribed genes resembles that of Pol II templates in many ways, although there are also clear differences. Our analysis also uncovered an entirely unexpected phenomenon: namely, that Pol II is present at the majority of genomic loci that are bound by Pol III.
authors.affiliation: Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: Artem
authors.initials: A
authors.lastname: Barski
authors.forename: Iouri
authors.initials: I
authors.lastname: Chepelev
authors.forename: Dritan
authors.initials: D
authors.lastname: Liko
authors.forename: Suresh
authors.initials: S
authors.lastname: Cuddapah
authors.forename: Alastair B
authors.initials: AB
authors.lastname: Fleming
authors.forename: Joanna
authors.initials: J
authors.lastname: Birch
authors.forename: Kairong
authors.initials: K
authors.lastname: Cui
authors.forename: Robert J
authors.initials: RJ
authors.lastname: White
authors.forename: Keji
authors.initials: K
authors.lastname: Zhao
mesh_terms: D001665:Binding Sites; D002460:Cell Line; D002843:Chromatin / Q000235:genetics; D004257:DNA Polymerase II / Q000235:genetics* / Q000378:metabolism; D044127:Epigenesis, Genetic; D015870:Gene Expression; D005796:Genes; D056426:Genetic Loci; D015894:Genome, Human; D006801:Humans; D012320:RNA Polymerase III / Q000032:analysis / Q000235:genetics* / Q000378:metabolism
chemical_list: D002843:Chromatin; D012320:RNA Polymerase III; D004257:DNA Polymerase II