High throughput cherry-picking of solvated samples.
Advances in the design of automated compound storage systems have made it possible to store large collections of research compounds in individual single-use aliquots dissolved in dimethyl sulfoxide and rapidly retrieve a specific group off them. This 'cherry-picking' approach offers researchers the opportunity to request large numbers of compounds desired for testing without having to also retrieve all the other compounds stored on the same rack or plate. This makes it possible to meet the increasing demand for samples from High Throughput Screening and Therapeutic Area teams without adding staff to dispense from powder each time, without the constraints imposed by storing in solvated compounds in fixed-well 96- or 384-way plates, and without sacrificing sample quality or shelf life by storing at room temperature. We describe how this approach has been implemented at Abbott Laboratories' central compound repository to provide smaller amounts of more compounds faster and with high quality. In doing so, we have been able to better support the innovation of our Drug Discovery colleagues.
Schmitt
Robert
R
Abbott Laboratories, 200 Abbott Park Road, Abbott Park, IL 60064, USA. robert.j.schmitt@abbott.com
Traphagen
Linda
L
Hajduk
Phillip
P
D053000:Analytic Sample Preparation Methods / Q000379:methods*; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D055808:Drug Discovery; D057166:High-Throughput Screening Assays / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012995:Solubility
D004364:Pharmaceutical Preparations; D004121:Dimethyl Sulfoxide