title: The short term effects of infected gallstones lost intraperitoneally.
abstract: In this experimental study, an animal model was set up to evaluate what sort of complications may cause intraperitoneal retained bile stones. Forty rats were divided into 4 groups. The first group was assigned as the control group and the subjects had only laparatomy. In the 2nd group, during laparotomy, sterile bile and bile stones were placed within the peritoneal cavity. In the 3rd group, contaminated bile and bile stones were placed within the peritoneal cavity. In the 4th group, again contaminated bile and bile stones were placed and prophylactic antibiotic (Ceftriaxon) was used for 7 days. After a 4 week interval, survivors were subjected to laparatomy and necropsy. As a conclusion, the peritoneal adhesion difference between the infected bile and stone inooculation group without antibiotic and the other group with antibiotic usage may show that antibiotics might prevent further complications in case of abdominal contamination. Available clinical and experimental data is not enough to recommend laparatomy to collect stones. We conclude that more detailed studies with larger series are necessary to clarify the issue (Tab. 1, Fig. 1, Ref. 26).
authors.affiliation: Department of General Surgery, Ankara Ataturk Research and Education Hospital, Bilkent-Yolu, Ankara 06800, Turkey.
authors.forename: Murat Ersen
authors.initials: ME
authors.lastname: Bekar
authors.forename: Ali Erkan
authors.initials: AE
authors.lastname: Ucar
authors.forename: Samet
authors.initials: S
authors.lastname: Yalcin
authors.forename: Bulent
authors.initials: B
authors.lastname: Yalcin
authors.forename: Ali
authors.initials: A
authors.lastname: Celik
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kusdemir
mesh_terms: D000818:Animals; D019072:Antibiotic Prophylaxis; D001646:Bile / Q000382:microbiology; D002769:Cholelithiasis / Q000601:surgery*; D005260:Female; D042882:Gallstones / Q000382:microbiology* / Q000473:pathology; D007431:Intraoperative Complications; D010529:Peritoneal Cavity / Q000382:microbiology; D051381:Rats; D000267:Tissue Adhesions / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*