Synthesis of 8-Heteroaryl-2'-deoxyguanosine Derivatives.
We describe the synthesis of 8-heteroaromatic-2'-deoxyguanosine analogues using Suzuki-Miyaura or Stille conditions. Unprotected and protected 8-bromo-2'-deoxyguanosine was coupled with commercially available heteroarylboronic acids or the trialkyltin derivatives of 2-pyridylbromides either with or without microwave irradiation in good yields.
Hobley
Gerard
G
Department of Chemistry, College of Natural Sciences, University of Puerto Rico, Río Piedras Campus, San Juan, Puerto Rico, PR-00931.
Gubala
Vladimir
V
Rivera-Sánchez
María Del C
MD
Rivera
José M
JM