Multistep microwave-assisted divergent synthesis of indolo-fused pyrazino-/diazepinoquinoxalinones on PEG support.
Synthesis of amino acid and indoline-substituted dinitrobenzene on a soluble polymer support (PEG) and its further reductive double-ring closure to afford structurally diverse indolo-fused pyrazino-/diazepinoquinoxalinones is described. Traceless synthesis of quinoxalinones coupled with application of the Pictet-Spengler-type condensation reaction furnished these novel scaffolds. These hitherto novel heterocycles are synthesized in shorter times under microwave irradiation conditions in comparison with that of classical reaction conditions.
Lai
Jin-Ji
JJ
Laboratory of Combinatorial Drug Discovery, Department of Applied Chemistry, National Chiao Tung University, Hsinchu, 300-10, Taiwan.
Salunke
Deepak B
DB
Sun
Chung-Ming
CM
D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry; D007211:Indoles / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry*; D011719:Pyrazines / Q000737:chemistry*; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000737:chemistry; D012995:Solubility; D013237:Stereoisomerism
D000596:Amino Acids; D007211:Indoles; D011719:Pyrazines; D011810:Quinoxalines; D011092:Polyethylene Glycols