title: Fast onset of action and the analgesic and sedative efficacy of essential oil from Rhizoma Chuanxiong after nasal administration.
abstract: In this study, the analgesic and sedative efficacy of Chuanxiong essential oil after nasal administration was compared with that of the commonly used oral administration route. The essential oil significantly reduced nociception only 5 min after nasal administration but not by i.g. administration. The essential oil significantly decreased the sleep latency and prolonged the sleeping time only 5 min after i.n. administration but not by the i.g. route. Taken together, these data demonstrate that the essential oil from Rhizoma Chuanxiong had faster onset of action as well as better analgesic and sedative efficacy after i.n. administration than given orally.
authors.affiliation: Jiangsu Key Laboratory for TCM formulae Research, Nanjing University of Chinese Medicine, Nanjing, P.R. China.
authors.forename: Jianming
authors.initials: J
authors.lastname: Guo
authors.forename: Jin-ao
authors.initials: JA
authors.lastname: Duan
authors.forename: Yuping
authors.initials: Y
authors.lastname: Tang
authors.forename: Ning
authors.initials: N
authors.lastname: Jia
authors.forename: Xinghu
authors.initials: X
authors.lastname: Li
authors.forename: Ji
authors.initials: J
authors.lastname: Zhang
mesh_terms: D019342:Acetic Acid; D000281:Administration, Intranasal; D018712:Analgesics, Non-Narcotic; D000818:Animals; D004357:Drug Synergism; D005260:Female; D006358:Hot Temperature; D006993:Hypnotics and Sedatives; D007202:Indicators and Reagents; D030004:Ligusticum / Q000737:chemistry*; D051379:Mice; D008813:Mice, Inbred ICR; D009822:Oils, Volatile / Q000008:administration & dosage / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects; D012890:Sleep / Q000187:drug effects
chemical_list: D018712:Analgesics, Non-Narcotic; D006993:Hypnotics and Sedatives; D007202:Indicators and Reagents; D009822:Oils, Volatile; D010936:Plant Extracts; D010424:Pentobarbital; D019342:Acetic Acid