title: Ischemic stroke during cisplatin-based chemotherapy for testicular germ cell tumor: case report and review of the literature.
abstract: Testicular germ-cell tumors are the most common solid tumor in young men, with an incidence peak between the ages of 20 and 35 years. Even if rare, arterial thromboembolism is a serious and possible complication during cisplatin-based chemotherapy in young patients. The strong association between rapid treatment and favorable outcome is well known. Oncologists need to recognize the symptoms and to alert a stroke unit as soon as possible. We report the management of a young patient affected by non seminomatous testicular neoplasm without cardiovascular risk factors who developed an ischemic stroke during cisplatin-based treatment. We also review the relevant literature.
authors.affiliation: Department of Radiation Oncology, University of Florence, Italy. icro.meattini@unifi.it
authors.forename: I
authors.initials: I
authors.lastname: Meattini
authors.forename: V
authors.initials: V
authors.lastname: Scotti
authors.forename: F
authors.initials: F
authors.lastname: Pescini
authors.forename: L
authors.initials: L
authors.lastname: Livi
authors.forename: S
authors.initials: S
authors.lastname: Sulprizio
authors.forename: V
authors.initials: V
authors.lastname: Palumbo
authors.forename: C
authors.initials: C
authors.lastname: Sarti
authors.forename: G
authors.initials: G
authors.lastname: Biti
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002545:Brain Ischemia / Q000139:chemically induced*; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy*; D020521:Stroke / Q000139:chemically induced*; D013736:Testicular Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D002945:Cisplatin