Guiding endosomal maturation.
In the endocytic pathway, early endosomes are converted into late endosomes by exchange of their associated Rab GTPases. In this issue, Poteryaev et al. (2010) identify the SAND-1/Mon1 protein as a switch that shuts off the recruitment of one Rab (Rab5) and facilitates the activation of the next (Rab7).
Cabrera
Margarita
M
Department of Biology/Chemistry, University of Osnabrück, Barbarastrasse 13, Osnabrück 49076, Germany.
Ungermann
Christian
C