Effect of gastric bypass on vitamin D and secondary hyperparathyroidism.
Obesity as well as bariatric surgery may increase the risk for vitamin D deficiency. We retrospectively compared vitamin D levels in obese patients (n = 123) prior to bariatric surgery and 1 year postoperatively. We also evaluated parathyroid hormone levels (PTH) 1 year after surgery. A higher percentage of patients had baseline vitamin D deficiency (86%), defined as 25-hydroxy vitamin D <32 ng/mL, compared with the 1-year (post-surgical) levels, (70%; p < 0.001). Body mass index (BMI) inversely correlated with vitamin D deficiency at baseline (r = -0.3, p = 0.06) and at the postoperative follow-up (r = -0.2, p = 0.013). One third of the postoperative population had secondary hyperparathyroidism, defined by a serum PTH level >62 pg/mL; however, postoperative PTH and vitamin D levels were unrelated (r = -0.001, p = 0.994). Pre- and postoperative vitamin D levels were inversely correlated with BMI. Secondary hyperparathyroidism was observed in 33% of patients postoperatively; however, this did not correlate with vitamin D.
Signori
Carina
C
Divisions of Cardiology, Nutrition and Preventive Medicine, Department of Medicine, William Beaumont Hospital, Royal Oak, MI 48073, USA.
Zalesin
Kerstyn C
KC
Franklin
Barry
B
Miller
Wendy L
WL
McCullough
Peter A
PA
D015992:Body Mass Index; D002118:Calcium / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D015390:Gastric Bypass / Q000009:adverse effects*; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D009767:Obesity, Morbid / Q000097:blood* / Q000150:complications / Q000601:surgery*; D010281:Parathyroid Hormone / Q000097:blood; D011184:Postoperative Period; D012189:Retrospective Studies; D012306:Risk; D014807:Vitamin D / Q000097:blood; D014808:Vitamin D Deficiency / Q000453:epidemiology / Q000209:etiology*; D015431:Weight Loss
D010281:Parathyroid Hormone; D014807:Vitamin D; D002118:Calcium