Importance of IL-18-induced super Th1 cells for the development of allergic inflammation.
Th1 cells, which express IL-18R, produce IFN-gamma in response to Ag and IL-2 and increase further production of IFN-gamma upon additional IL-18 stimulation. They simultaneously produce Th2 cytokines (IL-9 and IL-13), GM-CSF and chemokines (RANTES, MIP-1alpha). Human Th1 cells also produce IFN-gamma and IL-13 in response to anti-CD3 and IL-18. Recently, we demonstrated Th1 cells induce intrinsic type atopic asthma and dermatitis by production of Th1- and Th2-cytokines and chemokines. Here, we review the pathological roles of Th1 cells, stimulated with Ag and IL-18 in vivo, in the pathogenesis of allergic disorders by production of Th1 and Th2 cytokines and chemokines. Based on this unique function of Ag- plus IL-18-stimulated Th1 cells, we proposed to designate them as "super Th1 cells".
Nakanishi
Kenji
K
Department of Immunology and Medical Zoology, Hyogo College of Medicine, Hyogo, Japan. nakaken@hyo-med.ac.jp
Tsutsui
Hiroko
H
Yoshimoto
Tomohiro
T
D000485:Allergens / Q000276:immunology; D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology / Q000627:therapeutic use; D001249:Asthma / Q000150:complications / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D056726:Genetic Association Studies; D006801:Humans; D007239:Infections / Q000150:complications / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D007249:Inflammation; D020382:Interleukin-18 / Q000235:genetics / Q000276:immunology*; D008213:Lymphocyte Activation / Q000235:genetics; D018448:Models, Immunological; D011110:Polymorphism, Genetic; D053724:Receptors, Interleukin-18 / Q000037:antagonists & inhibitors / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*
D000485:Allergens; D018926:Anti-Allergic Agents; D020382:Interleukin-18; D053724:Receptors, Interleukin-18