title: Association between an ASIC3 gene variant and insulin resistance in Taiwanese.
abstract: BACKGROUND
  Acid-sensing ion channel 3 (ASIC3) is a ligand-gated cation channel activated by extracellular protons. ASIC3(-/-) mice exhibit protection against age-dependent glucose intolerance with enhanced insulin sensitivity.
  
  
  METHODS
  To determine the association between ASIC3 genetic polymorphisms and insulin resistance in Taiwanese, 606 unrelated subjects with no history of cardiovascular disease were recruited during routine health examinations.
  
  
  RESULTS
  Six ASIC3 gene polymorphisms were genotyped and only the rs2288646 polymorphism was found associated with insulin resistance. Significantly lower fasting serum insulin levels and homeostasis model assessment of insulin resistance (HOMA-IR) index and significantly higher quantitative insulin sensitivity check index (QUICKI) were observed in subjects carrying the rs2288646-A allele than in the non-carriers (P=0.028, P=0.047 and P=0.031, respectively) after adjustment for age, gender, and body mass index (BMI). Significantly lower frequencies of the rs2288646-A-containing genotypes were found in insulin resistant subjects (P=0.023). By multivariate analysis, rs2288646 genotypes, age, BMI, fasting plasma glucose level, C-reactive protein level, and soluble intercellular adhesive molecule 1 level, were all independently associated with HOMA-IR index and QUICKI (all, P<0.05).
  
  
  CONCLUSIONS
  Our analysis indicated an independent association between an ASIC3 genetic polymorphism and insulin resistance in Taiwanese.
authors.affiliation: Department of Life Science, Chinese Culture University, Taipei, Taiwan.
authors.forename: Semon
authors.initials: S
authors.lastname: Wu
authors.forename: Lung-An
authors.initials: LA
authors.lastname: Hsu
authors.forename: Hsin-Hua
authors.initials: HH
authors.lastname: Chou
authors.forename: Ming-Sheng
authors.initials: MS
authors.lastname: Teng
authors.forename: Hsien-Hsun
authors.initials: HH
authors.lastname: Chang
authors.forename: Kuan Hung
authors.initials: KH
authors.lastname: Yeh
authors.forename: Chih-Cheng
authors.initials: CC
authors.lastname: Chen
authors.forename: Pi-Yueh
authors.initials: PY
authors.lastname: Chang
authors.forename: Ching-Feng
authors.initials: CF
authors.lastname: Cheng
authors.forename: Yu-Lin
authors.initials: YL
authors.lastname: Ko
mesh_terms: D062565:Acid Sensing Ion Channels; D044466:Asian People / Q000235:genetics*; D015415:Biomarkers / Q000378:metabolism; D005260:Female; D014644:Genetic Variation; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic; D015222:Sodium Channels / Q000235:genetics*; D013624:Taiwan
chemical_list: C112231:ASIC3 protein, human; D062565:Acid Sensing Ion Channels; D015415:Biomarkers; D015222:Sodium Channels; D005947:Glucose