title: Ceramide-mediated transport of chloride and bicarbonate across phospholipid membranes.
abstract: The sphingolipid, ceramide 1, facilitates transport of Cl(-) and HCO(3)(-) anions across lipid bilayers under conditions where large transmembrane pores are not formed. Ceramide's 1,3-diol unit is essential for both binding and transporting these anions.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20740, USA.
authors.forename: William A
authors.initials: WA
authors.lastname: Harrell
authors.forename: Marie Liesel
authors.initials: ML
authors.lastname: Bergmeyer
authors.forename: Peter Y
authors.initials: PY
authors.lastname: Zavalij
authors.forename: Jeffery T
authors.initials: JT
authors.lastname: Davis
mesh_terms: D001639:Bicarbonates / Q000378:metabolism*; D001692:Biological Transport; D002518:Ceramides / Q000737:chemistry* / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism*; D008051:Lipid Bilayers / Q000737:chemistry*
chemical_list: D001639:Bicarbonates; D002518:Ceramides; D002712:Chlorides; D008051:Lipid Bilayers