title: Catalytic enantioselective Mannich-type reaction with beta-phenyl sulfonyl acetonitrile.
abstract: The organocatalytic addition of beta-phenyl sulfonyl acetonitrile 1 to either N-Boc-protected alpha-amido sulfones or imines allowed the synthesis of enantioenriched alpha-unsubstituted beta-amino nitriles through a Mannich-type reaction.
authors.affiliation: Departamento de Química Orgánica I, Facultad de Química, Universidad del País Vasco, Apdo. 1072, 20080 San Sebastián, Spain.
authors.forename: Pedro B
authors.initials: PB
authors.lastname: González
authors.forename: Rosa
authors.initials: R
authors.lastname: Lopez
authors.forename: Claudio
authors.initials: C
authors.lastname: Palomo
mesh_terms: D000097:Acetonitriles / Q000737:chemistry*; D002384:Catalysis; D007097:Imines / Q000737:chemistry; D009570:Nitriles / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013450:Sulfones / Q000737:chemistry*
chemical_list: D000097:Acetonitriles; D007097:Imines; D009570:Nitriles; D013450:Sulfones; C032159:acetonitrile