title: Tributyltin hydride-mediated radical cyclisation reactions: efficient construction of multiply substituted cyclopentanes.
abstract: The nBu(3)SnH-mediated cyclisation reactions of allylic-allylic alkylation products of alpha,alpha-dicyanoalkenes and Morita-Baylis-Hillman (MBH) carbonates of methyl vinyl ketone (MVK) have been investigated. Cyclopentane derivatives bearing multiple substituents were efficiently prepared with moderate to excellent diastereoselectivity.
authors.affiliation: State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Lei
authors.forename: Hai-Lei
authors.initials: HL
authors.lastname: Cui
authors.forename: Rui
authors.initials: R
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Wu
authors.forename: Zheng-Yu
authors.initials: ZY
authors.lastname: Ding
authors.forename: Ying-Chun
authors.initials: YC
authors.lastname: Chen
mesh_terms: D002384:Catalysis; D003500:Cyclization; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014220:Trialkyltin Compounds / Q000737:chemistry*
chemical_list: D003517:Cyclopentanes; D014220:Trialkyltin Compounds; C011559:tributyltin