Distinctively low levels of serum 8-hydroxydeoxyguanosine in women with polycystic ovary syndrome.
OBJECTIVE
To investigate oxidative stress and angiogenetic factors in polycystic ovary syndrome (PCOS).


METHODS
Prospective cohort study.


METHODS
University outpatient clinic.


METHODS
Fifty women with PCOS were divided into two groups: body mass index (BMI) >27 kg/m(2) (n = 25) and BMI <27 kg/m(2) (n = 25). The control group consisted of 20 age- and BMI-matched healthy women.


METHODS
None.


METHODS
Enzyme-linked immunosorbent assays were used to measure serum levels of 8-hydroxydeoxyguanosine (8-OHdG), angiopoietin-2, and vascular endothelial growth factor (VEGF).


RESULTS
Women with PCOS had significantly lower serum 8-OHdG levels (mean 137.8 pg/mL, range 53.4-282.9 pg/mL) compared with the control subjects (mean 219.78 pg/mL, 124.6-372.4 pg/mL). This difference was obvious in both lean (BMI <27 kg/m(2)) and obese (BMI >27 kg/m(2)) subjects. Concentrations of VEGF were higher among obese subjects with PCOS.


CONCLUSIONS
Serum 8-OHdG levels are significantly lower in women with PCOS than in healthy controls. The clinical significance of this finding is discussed.
Sova
Henri
H
Department of Oncology and Radiotherapy, Oulu University Hospital and University of Oulu, Oulu, Finland. henrijuh@mail.student.oulu.fi
Morin-Papunen
Laure
L
Puistola
Ulla
U
Karihtala
Peeter
P
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D042702:Angiopoietin-2 / Q000097:blood / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000032:analysis / Q000097:blood / Q000378:metabolism; D015536:Down-Regulation; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000097:blood / Q000378:metabolism; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000378:metabolism; D055815:Young Adult
D042702:Angiopoietin-2; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine