title: Noninvasive markers to diagnose cirrhosis in patients with HBeAg positive chronic hepatitis: Do new biomarkers improve the accuracy?
abstract: OBJECTIVE
  The goal of the study was to clarify whether new biomarkers independently contribute to the diagnosis of cirrhosis.
  
  
  METHODS
  A total of 142 consecutive patients with HBeAg positive chronic hepatitis who underwent liver biopsy were recruited. The Cirrhosis Score (CS)-1 was derived from routine laboratory data only. The CS-2 was calculated using all correlates obtained from both routine laboratory data and 7 new biomarkers.
  
  
  RESULTS
  A comparison of the area under the receiver operating characteristic (ROC) curve between CS-1 [0.84 (95% CI, 0.74 to 0.94)] and CS-2 [0.86 (0.78 to 0.95)] showed no superior diagnostic accuracy of CS-2 over CS-1 (p=0.24).
  
  
  CONCLUSIONS
  None of the new biomarkers had value in addition to readily available laboratory data for differentiating cirrhosis from HBeAg positive chronic hepatitis B.
authors.affiliation: Department of Internal Medicine, Inje University Haeundae Paik-Hospital, Busan, Republic of Korea.
authors.forename: Seung Ha
authors.initials: SH
authors.lastname: Park
authors.forename: Dong Joon
authors.initials: DJ
authors.lastname: Kim
authors.forename: Jae Youn
authors.initials: JY
authors.lastname: Cheong
authors.forename: Sung Won
authors.initials: SW
authors.lastname: Cho
authors.forename: Seong Gyu
authors.initials: SG
authors.lastname: Hwang
authors.forename: Youn Jae
authors.initials: YJ
authors.lastname: Lee
authors.forename: Mong
authors.initials: M
authors.lastname: Cho
authors.forename: Jin Mo
authors.initials: JM
authors.lastname: Yang
authors.forename: Young Bae
authors.initials: YB
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D044963:Biopsy, Fine-Needle; D018450:Disease Progression; D005260:Female; D006513:Hepatitis B e Antigens / Q000097:blood*; D019694:Hepatitis B, Chronic / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000145:classification / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D055815:Young Adult
chemical_list: D015415:Biomarkers; D006513:Hepatitis B e Antigens