title: Immunolocalization of NK-1 receptor and Substance P in human normal placenta.
abstract: A role for Substance P (SP) in human placenta is not known, although is possible that regulates placental physiology through the Neurokinin (NK)-1 receptor. Ten human normal placenta tissues were studied by immunohistochemistry to demonstrate the localization of NK-1 receptor and SP. An immunostaining pattern for NK-1 receptor and SP was observed in the endothelium and myocytes of fetal blood vessels, decidua and trophoblast. The SP is located in both the cytoplasm and the nucleus whereas NK-1 receptor in cytoplasmic. These findings reported here for the fist time, suggest a role for the SP and NK-1 receptor in the placental physiology.
authors.affiliation: Research Laboratory on Neuropeptides, Virgen del Rocío University Children's Hospital, Sevilla, Spain. mmunoz@cica.es
authors.forename: M
authors.initials: M
authors.lastname: Muñoz
authors.forename: A
authors.initials: A
authors.lastname: Pavón
authors.forename: M
authors.initials: M
authors.lastname: Rosso
authors.forename: M V
authors.initials: MV
authors.lastname: Salinas
authors.forename: A
authors.initials: A
authors.lastname: Pérez
authors.forename: A
authors.initials: A
authors.lastname: Carranza
authors.forename: A
authors.initials: A
authors.lastname: González-Ortega
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D003656:Decidua / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D018040:Receptors, Neurokinin-1 / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*; D014327:Trophoblasts / Q000378:metabolism
chemical_list: D018040:Receptors, Neurokinin-1; D013373:Substance P