Association between albuminuria, carotid atherosclerosis, arterial stiffness, and peripheral arterial disease in Korean type 2 diabetic patients.
BACKGROUND
To evaluate the association between albuminuria, carotid atherosclerosis, arterial stiffness, and peripheral arterial disease (PAD) in Korean type 2 diabetic patients.


METHODS
In total, 673 type 2 diabetic patients registered with the public health center participated. Following an overnight fast, venous blood and urine samples were collected and analyzed. The carotid intima-media thickness (IMT), amount of carotid plaque, brachial ankle pulse wave velocity (baPWV), and the ankle-brachial index of each patient were also assessed.


RESULTS
Albuminuria was significantly associated with PAD (odds ratio (OR) 2.33; 95% confidence interval (CI) 1.28-4.25 for normoalbuminuria vs. microalbuminuria and OR 3.28; 95% CI 1.40-7.66 for normoalbuminuria vs. macroalbuminuria), but not with carotid plaque. The mean baPWV differed significantly according to the level of albumin relative to the creatinine ratio (1,764.79, 1,778.98, and 2,001.33, respectively; p < 0.001), while no significant difference was observed in the mean IMT value (0.73, 0.74, and 0.72, respectively; p = 0.399).


CONCLUSIONS
Albuminuria was significantly associated with baPWV and PAD, but not with carotid plaque or CCA-IMT, in Korean type 2 diabetic patients.
Choi
Seong-Woo
SW
Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, Republic of Korea.
Yun
Woo-Jun
WJ
Kim
Hey-Yeon
HY
Lee
Young-Hoon
YH
Kweon
Sun-Seog
SS
Rhee
Jung-Ae
JA
Choi
Jin-Su
JS
Shin
Min-Ho
MH
D000368:Aged; D000419:Albuminuria / Q000150:complications* / Q000503:physiopathology*; D001158:Arteries / Q000503:physiopathology; D002340:Carotid Artery Diseases / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000209:etiology; D014655:Vascular Resistance