title: Unprecedented Cu(I)-catalyzed microwave-assisted three-component coupling of a ketone, an alkyne, and a primary amine.
abstract: An efficient, microwave-assisted Cu(I)-catalyzed one-pot coupling of a ketone, an alkyne, and a primary amine (KA(2) coupling) is described, giving access to secondary propargylamines.
authors.affiliation: Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
authors.forename: Olga P
authors.initials: OP
authors.lastname: Pereshivko
authors.forename: Vsevolod A
authors.initials: VA
authors.lastname: Peshkov
authors.forename: Erik V
authors.initials: EV
authors.lastname: Van der Eycken
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry*; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D010293:Pargyline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D011437:Propylamines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D000588:Amines; D007659:Ketones; D011437:Propylamines; C009054:propargylamine; D003300:Copper; D010293:Pargyline