Drug releasing polymer thin films: new era of surface-mediated drug delivery.
Polymer films and coatings are among the popular and most successful tools to modulate surface properties of biomaterials, specifically tissue responses and fouling behavior. Over the past decade, a novel opportunity has been widely investigated, namely utility of surface coatings in surface-mediated drug delivery. In these applications, deposited polymer films act as both a coating to modulate surface properties and a reservoir for active therapeutic cargo. The field has recently accelerated beyond the proof-of-concept reports toward delivering practical solutions and established technologies for biomedical applications. This review briefly summarizes the recent successes of polymer thin films, specifically those constructed by sequential polymer deposition technique, in surface-mediated drug delivery.
Zelikin
Alexander N
AN
Department of Chemistry and Interdisciplinary Nanoscience Center, Aarhus University, Aarhus C 8000, Denmark. zelikin@chem.au.dk
D000818:Animals; D001704:Biopolymers / Q000737:chemistry / Q000378:metabolism; D002448:Cell Adhesion / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D004337:Drug Carriers / Q000737:chemistry* / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D013499:Surface Properties
D001704:Biopolymers; D004337:Drug Carriers; D011108:Polymers