title: [Immunosuppressive triterpenes from Tetraena mongolica].
abstract: OBJECTIVE
  To study the immunosuppressive constituents from Tetraena mongolica.
  
  
  METHODS
  Chemical constituents were isolated and purified by repeated column chromatography( silica gel, Toyopearl HW40C and preparative HPLC). Their structures were elucidated on the basis of spectral data analysis. The MTT assay was applied to evaluate the isolated compounds on the inhibition effect of lymphocyte transformation.
  
  
  RESULTS
  Six triterpenes were isolated and their structures were identified as follows: 3beta-hydroxy-11alpha, 12alpha:13beta,28-diepoxyoleanane(1), 3beta-(3, 4-dihydroxycinnamoyl)-erythrodi-ol(2), olean-28-al-3beta-yl-caffeate(3), erythrodiol (4), 12-oleanaen-3beta-caffeate(5), 3-O-(E) -coumaroylerythrodiol(6). Compound 24 exhibited the inhibition effects on lymphocyte transformation.
  
  
  CONCLUSIONS
  Compounds 1-6 were isolated from this plant for the first time, and compound 1 was a new nature product. Compound 2-4 showed significant immunosuppressive activity.
authors.affiliation: Research Center of Basic Medical Sciences, School of Pharmaceutical Sciences, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Linlin
authors.initials: L
authors.lastname: Ding
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Jiaxu
authors.initials: J
authors.lastname: Hu
authors.forename: Shengan
authors.initials: S
authors.lastname: Tang
authors.forename: Hongquan
authors.initials: H
authors.lastname: Duan
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D007166:Immunosuppressive Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D028461:Zygophyllaceae / Q000737:chemistry*
chemical_list: D007166:Immunosuppressive Agents; D014315:Triterpenes