[GluR2 expression in the developing rat inferior colliculus and the relationship with development of synapse].
OBJECTIVE
To observe the GluR2 expression in rat inferior colliculus (IC) in different developmental stages, and to investigate its developmental change and relationship with the synapse development.


METHODS
The expression of GluR2 and synaptophysin(SYP) in IC were detected by double immunofluorescence method.


RESULTS
(1) All sorts of neurons in IC expressed GluR2 in every postnatal groups, and the GluR2 expression in P6w groups was higher than that in other groups. (2) The expression of GluR2 were different in different subnucleus of IC. (3) All sorts of neurons in IC expressed SYP in every postnatal groups, and the SYP expression in P6w groups was higher than others. (4) The expressions of GluR2 consistent with the expression of SYP in IC.


CONCLUSIONS
The developmental changes of GluR2 and SYP expression in the rat IC may be involved in the development and plasticity of auditory center.
Shen
Yuling
Y
Department of Otolaryngology Head and Neck Surgery, Renji Hospital Affiliated Shanghai Jiaotong University, Shanghai, China.
Jin
Xiaojie
X
D000818:Animals; D007031:Hypothalamus / Q000166:cytology / Q000378:metabolism*; D007245:Inferior Colliculi / Q000254:growth & development / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism*; D016708:Synaptophysin / Q000378:metabolism*
D018091:Receptors, AMPA; D016708:Synaptophysin; C104722:glutamate receptor ionotropic, AMPA 2