[In vitro activities of Odorrana grahami antimicrobial peptides from skin against 5 pathogenic bacteria].
OBJECTIVE
To evaluate the efficiency of 4 Odorrana grahami antimicrobial peptides from skin against 5 pathogenic bacteria, include 2 wild strains and 7 resistant strains.


METHODS
Broth microdilution antimicrobial susceptibility test was used for bacteria that growed aerobically.


RESULTS
The 4 Odorrana grahami antimicrobial peptides were basically in vitro efficient agents for inhibition against to methicillin-resistant coagulase negative Staphylococcus (MRSCN, 85460), wild Staphylococcus aureus (24157), penicillin-resistant Streptococcus pneumoniae (PRSP, 84688 and 91452), class I beta-lactamase Enterobacter cloacae (AmpC, 85439 and 93543), wild Escherichia coli (84492), extended-spectrum beta-lactamases Escherichia coli (ESBL, 84492), inhabitor-resistant TEM beta-lactamase Escherichia coli (IRT, 85580).


CONCLUSIONS
The 4 Odorrana grahami antimicrobial peptides from skin have broad spectrum antimicrobial activity; especially have in vitro activity to resistant strains. So it is hopeful to be developed as the antimicrobial agent as well as the disinfectant and the antiseptic.
Liu
Jiong-yu
JY
Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China.
Zhang
Li
L
Jiang
Jian-ping
JP
Wang
Xiao-lei
XL
Xie
Feng
F
Zheng
Zhong-hua
ZH
D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D024881:Drug Resistance, Bacterial; D016983:Enterococcus / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects; D008419:Materia Medica / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011898:Ranidae; D012680:Sensitivity and Specificity; D012867:Skin / Q000737:chemistry* / Q000378:metabolism; D013210:Staphylococcus / Q000187:drug effects
D023181:Antimicrobial Cationic Peptides; D008419:Materia Medica