title: Recruitment methods in Alzheimer's disease research: general practice versus population based screening by mail.
abstract: BACKGROUND
  In Alzheimer's disease (AD) research patients are usually recruited from clinical practice, memory clinics or nursing homes. Lack of standardised inclusion and diagnostic criteria is a major concern in current AD studies. The aim of the study was to explore whether patient characteristics differ between study samples recruited from general practice and from a population based screening by mail within the same geographic areas in rural Northern Norway.
  
  
  METHODS
  An interventional study in nine municipalities with 70000 inhabitants was designed. Patients were recruited from general practice or by population based screening of cognitive function by mail. We sent a questionnaire to 11807 individuals > or = 65 years of age of whom 3767 responded. Among these, 438 individuals whose answers raised a suspicion of cognitive impairment were invited to an extended cognitive and clinical examination. Descriptive statistics, chi-square, independent sample t-test and analyses of covariance adjusted for possible confounders were used.
  
  
  RESULTS
  The final study samples included 100 patients recruited by screening and 87 from general practice. Screening through mail recruited younger and more self-reliant male patients with a higher MMSE sum score, whereas older women with more severe cognitive impairment were recruited from general practice. Adjustment for age did not alter the statistically significant differences of cognitive function, self-reliance and gender distribution between patients recruited by screening and from general practice.
  
  
  CONCLUSIONS
  Different recruitment procedures of individuals with cognitive impairment provided study samples with different demographic characteristics. Initial cognitive screening by mail, preceding extended cognitive testing and clinical examination may be a suitable recruitment strategy in studies of early stage AD. CLINICAL REGISTRATION: ClinicalTrial.gov Identifier: NCT00443014.
authors.affiliation: Department of Community Medicine, University of Tromsø, N-9037 Tromsø, Norway. frea@online.no
authors.forename: Fred
authors.initials: F
authors.lastname: Andersen
authors.forename: Torgeir A
authors.initials: TA
authors.lastname: Engstad
authors.forename: Bjørn
authors.initials: B
authors.lastname: Straume
authors.forename: Matti
authors.initials: M
authors.lastname: Viitanen
authors.forename: Dag S
authors.initials: DS
authors.lastname: Halvorsen
authors.forename: Samuel
authors.initials: S
authors.lastname: Hykkerud
authors.forename: Kjell
authors.initials: K
authors.lastname: Sjøbrend
mesh_terms: D017677:Age Distribution; D000544:Alzheimer Disease; D005260:Female; D058006:General Practice; D006801:Humans; D008297:Male; D009664:Norway; D018579:Patient Selection; D011177:Postal Service; D017678:Sex Distribution; D011795:Surveys and Questionnaires