A possible case of mixed mania due to neurosarcoidosis treated successfully with methylprednisolone and ziprasidone: another example of frontal-subcortical disinhibition?
Sarcoidosis is an idiopathic systemic granulomatous disease recognized by clinical and radiographic findings, which ultimately require histopathologic confirmation of noncaseating granulomas for a definitive diagnosis. Psychiatric manifestations occur in 20% of patient with neurosarcoidosis [http://dynaweb.ebscohost.com.chekov.evms.edu/Detail.aspx?id=306337&sid=bdce39cc-d2bd-4977-9e4d-786f2e768d57@sessionmgr4]. We present a case of suspected mixed mania due to neurosarcoidosis, with the manic symptoms responding early and robustly to ziprasidone.
Spiegel
David R
DR
Department of Psychiatry, Eastern Virginia Medical School, Norfolk, VA 23507, USA. spiegedr@evms.edu
Thomas
Christopher S
CS
Shah
Pallav
P
Kent
Kristin D
KD
D000328:Adult; D001741:Black or African American; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000209:etiology* / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology; D005260:Female; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D012507:Sarcoidosis / Q000150:complications / Q000188:drug therapy*; D013844:Thiazoles / Q000627:therapeutic use*; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D014150:Antipsychotic Agents; D010879:Piperazines; D013844:Thiazoles; C092292:ziprasidone; D008775:Methylprednisolone