title: Direct synthesis of trisubstituted isoxazoles through gold-catalyzed domino reaction of alkynyl oxime ethers.
abstract: Alkynyl oxime ether underwent a gold-catalyzed domino reaction involving cyclization and subsequent Claisen-type rearrangement to afford trisubstituted isoxazoles in a direct, efficient, and regioselective manner. The products were successfully applied to the synthesis of unusual heterocycles as an illustration of the potential utility of the reaction.
authors.affiliation: Kobe Pharmaceutical University, Motoyamakita, Higashinada, Kobe 658-8558, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Ueda
authors.forename: Aoi
authors.initials: A
authors.lastname: Sato
authors.forename: Yuki
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Takeaki
authors.initials: T
authors.lastname: Naito
authors.forename: Okiko
authors.initials: O
authors.lastname: Miyata
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D004987:Ethers / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010091:Oximes / Q000737:chemistry*
chemical_list: D000480:Alkynes; D004987:Ethers; D007555:Isoxazoles; D010091:Oximes; D006046:Gold