title: A 41-year-old woman with von Hippel-Lindau and a cerebellar lesion.
abstract: A 41-year-old woman with a 12-year history of von Hippel-Lindau disease presented with progressive quadriparesis and difficulty swallowing. MRI revealed a well-circumscribed, partially cystic cerebellar neoplasm, consistent with hemangioblastoma. The tumor was resected and the diagnosis of hemangioblastoma confirmed. Embedded within the hemangioblastoma was a small focus of metastatic renal cell carcinoma (RCC). RCC metastatic to a CNS hemangioblastoma is the second most common type of tumor-to-tumor metastasis, which may be due to a number of factors. Proper immunostaining panels are required to clearly identify these cases since both tumor may have similar histology.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Martin
authors.forename: Sohaib M
authors.initials: SM
authors.lastname: Al-Khatib
authors.forename: Michael S
authors.initials: MS
authors.lastname: Turner
authors.forename: Annette C
authors.initials: AC
authors.lastname: Douglas-Akinwande
authors.forename: Eyas M
authors.initials: EM
authors.lastname: Hattab
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D002528:Cerebellar Neoplasms / Q000175:diagnosis / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D018325:Hemangioblastoma / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology; D008279:Magnetic Resonance Imaging; D006623:von Hippel-Lindau Disease / Q000175:diagnosis / Q000473:pathology*