title: Codon usage biases in Alzheimer's disease and other neurodegenerative diseases.
abstract: Establishing codon usage biases are crucial for understanding the etiology of central nervous system neurodegenerative diseases (CNSNDD) especially Alzheimer's disease (AD) as well as genetic factors. G and C ending codons are strongly biased in the coding sequences of these proteins as a result of genomic GC composition constraints. On the other hand, codons that identified as translationally optimal in the major trend all end in C or G, suggesting translational selection should also be taken into consideration additional to compositional constraints. Furthermore, this investigation reveals that three common codons, CGC (Arg), AGC (Ser), and GGC (Gly), are also critical in affecting codon usage bias. They not only can offer an insight into the codon usage bias of AD and its mechanism, but also may help in the possible cures for these diseases.
authors.affiliation: State Key Laboratory of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210093, China. yangjie@nju.edu.cn
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.forename: Tong-Yang
authors.initials: TY
authors.lastname: Zhu
authors.forename: Zheng-Xin
authors.initials: ZX
authors.lastname: Jiang
authors.forename: Cheng
authors.initials: C
authors.lastname: Chen
authors.forename: Yue-Lan
authors.initials: YL
authors.lastname: Wang
authors.forename: Song
authors.initials: S
authors.lastname: Zhang
authors.forename: Xiong-Fei
authors.initials: XF
authors.lastname: Jiang
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Wang
authors.forename: Wen-Hao
authors.initials: WH
authors.lastname: Xia
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Ji-Jun
authors.initials: JJ
authors.lastname: Chen
authors.forename: Jia-Yue
authors.initials: JY
authors.lastname: Wang
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Wang
authors.forename: Wei-Juan
authors.initials: WJ
authors.lastname: Zheng
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism; D000596:Amino Acids / Q000235:genetics; D001482:Base Composition; D016009:Chi-Square Distribution; D003062:Codon; D019295:Computational Biology / Q000379:methods; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics* / Q000378:metabolism; D011506:Proteins / Q000737:chemistry / Q000235:genetics
chemical_list: D000596:Amino Acids; D003062:Codon; D011506:Proteins