Analysis of MIF, FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population.
In order to investigate the influence of functional polymorphisms of macrophage migration inhibitory factor (MIF), Fcg receptors CD16A (FCGR3A) and CD32A (FCGR2A) genes on susceptibility to pulmonary tuberculosis (PTB) in the Moroccan population, we analyzed 123 patients with PTB and 154 healthy controls. The genotyping for MIF-173 (G/C) (rs755622), FCGR2A-131H/R (rs1801274) and FCGR3A-158V/F (rs396991) was carried out using TaqMan SNP Genotyping Assay method. We found a statistically significant increase of the MIF -173CC homozygote genotype and MIF -173*C allele frequencies in PTB patients compared with healthy controls (17.07%versus 5.84%, P = 0.003; and 35.37%versus 26.30%, P = 0.02; respectively). In contrast, no association was observed between FCGR2A-131H/R and FCGR3A-158V/F polymorphisms and tuberculosis disease. Our finding suggests that MIF -173*C variant may play an important role in the development of active tuberculosis.
Sadki
Khalid
K
Human Genomic Unit, Laboratory of Immunology, National Institute of Hygiene, Rabat 10000, Morocco. ksadki1@yahoo.fr
Lamsyah
Hoda
H
Rueda
Blanca
B
Akil
Elmahfoud
E
Sadak
Abderrahim
A
Martin
Javier
J
El Aouad
Rajae
R
D004198:Disease Susceptibility; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D014644:Genetic Variation; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000235:genetics*; D009018:Morocco; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D044382:Population Groups; D011401:Promoter Regions, Genetic / Q000235:genetics; D017452:Receptors, IgG / Q000235:genetics*; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
C445323:FCGR2A protein, human; C496124:FCGR3A protein, human; D008263:Macrophage Migration-Inhibitory Factors; D017452:Receptors, IgG