Controllable and uncontrollable Stanford type B aortic dissection in canine models.
OBJECTIVE
Stanford type A and type B aortic dissections are anatomically distinct. Few animal models appropriately mimic human aortic dissection in the clinical setting. We developed animal models that mimicked uncontrollable Stanford type B aortic dissection as well as controllable dissection.


METHODS
Twelve female beagle dogs were randomly assigned to the uncontrollable dissection model, and 8 to the controllable. After creation of the false lumen using a self-made separator, epinephrine was injected acutely in the uncontrollable model, and a rapid injection of saline expanded the false lumen in the controllable model using a balloon catheter.


RESULTS
All models mimicked Stanford type B dissection at autopsy. Dissections formed in 9 of the 12 animals of the uncontrollable model as confirmed by digital subtraction angiography (DSA) performed 1 week after surgery. For the controllable dissection model, 6 out of 8 animals survived, and dissection was confirmed by DSA. Occlusion of the dissection developed 4 weeks after surgery in all 6 cases.


CONCLUSIONS
We have developed an easy, stable animal model of Stanford type B dissection which provides a great length of false lumen and appears very similar to aortic dissection in humans.
Tang
J
J
Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. drtangjingdong @ 126.com
Wang
Y
Y
Hang
W
W
Fu
W
W
Jing
Z
Z
D000784:Aortic Dissection / Q000145:classification / Q000209:etiology* / Q000473:pathology; D000818:Animals; D001013:Aorta, Thoracic / Q000601:surgery; D017545:Aortic Aneurysm, Thoracic / Q000145:classification / Q000209:etiology* / Q000473:pathology; D021721:Balloon Occlusion; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D006801:Humans