title: Down syndrome maternal serum screening in patients with renal disease.
abstract: OBJECTIVE
  The objective of the study was to determine the value of maternal serum Down syndrome screening in patients affected by renal disease.
  
  
  METHODS
  A study group of 54 pregnant women with renal diseases defined before pregnancy, was compared with a control group of 108 patients matched for maternal age, maternal weight, smoking status, and gestational age. Maternal serum markers (free beta-human chorionic gonadotropin [hCG], total hCG, alpha-fetoprotein) expressed in multiple of median and maternal renal function markers (creatinine, beta2-microglobulin, alpha1-microglobulin) were assayed.
  
  
  RESULTS
  The percentage of patients in the Down syndrome at-risk group (>1:250) using free beta-hCG was significantly higher (P < .02) in the renal disease group (48%) than in the control group (12%). No significant difference was observed for total hCG (25% vs 15%).
  
  
  CONCLUSIONS
  Down syndrome screening using free beta-hCG is not applicable in patients with renal disease whatever the maternal serum creatinine and can be used with caution when total hCG is used.
authors.affiliation: Department of Obstetrics and Gynecology, Hôpital Necker Enfants Malades, Assistance Publique Hôpitaux de Paris, Université Paris Descartes, Paris, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Benachi
authors.forename: Sophie
authors.initials: S
authors.lastname: Dreux
authors.forename: Sahar
authors.initials: S
authors.lastname: Kaddioui-Maalej
authors.forename: Isabelle
authors.initials: I
authors.lastname: Czerkiewicz
authors.forename: Fadi
authors.initials: F
authors.lastname: Fakhouri
authors.forename: Eric
authors.initials: E
authors.lastname: Thervet
authors.forename: Françoise
authors.initials: F
authors.lastname: Muller
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D003404:Creatinine / Q000097:blood; D004314:Down Syndrome / Q000175:diagnosis*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000097:blood*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D011296:Prenatal Diagnosis / Q000379:methods*; D018709:Statistics, Nonparametric; D055815:Young Adult; D000509:alpha-Fetoproteins / Q000378:metabolism; D001613:beta 2-Microglobulin / Q000097:blood
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D000509:alpha-Fetoproteins; D001613:beta 2-Microglobulin; D003404:Creatinine