Functional multineuron calcium imaging for systems pharmacology.
Functional multineuron calcium imaging (fMCI) is a large-scale technique used to access brain function on a single-neuron scale. It detects the activity of individual neurons by imaging action potential-evoked transient calcium influxes into their cell bodies. fMCI has recently been used as a high-throughput research tool to examine how neuronal activity is altered in animal models of brain diseases, for example stroke, Alzheimer's disease, and epilepsy, and to estimate how pharmacological agents act on normal and abnormal states of neuronal networks. It offers unique opportunities to discover the mechanisms underlying neurological disorders and new therapeutic targets.
Takahashi
Naoya
N
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Takahara
Yuji
Y
Ishikawa
Daisuke
D
Matsuki
Norio
N
Ikegaya
Yuji
Y
D000200:Action Potentials; D000818:Animals; D001927:Brain Diseases / Q000175:diagnosis* / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D003952:Diagnostic Imaging; D006801:Humans; D009474:Neurons / Q000502:physiology*
D002118:Calcium