title: Design considerations for pulsed-flow comprehensive two-dimensional GC: dynamic flow model approach.
abstract: A dynamic flow model, which maps carrier gas pressures and carrier gas flow rates through the first dimension separation column, the modulator sample loop, and the second dimension separation column(s) in a pulsed-flow modulation comprehensive two-dimensional gas chromatography (PFM-GCxGC) system is described. The dynamic flow model assists design of a PFM-GCxGC modulator and leads to rapid determination of pneumatic conditions, timing parameters, and the dimensions of the separation columns and connecting tubing used to construct the PFM-GCxGC system. Three significant innovations are introduced in this manuscript, which were all uncovered by using the dynamic flow model. A symmetric flow path modulator improves baseline stability, appropriate selection of the flow restrictors in the first dimension column assembly provides a generally more stable and robust system, and these restrictors increase the modulation period flexibility of the PFM-GCxGC system. The flexibility of a PFM-GCxGC system resulting from these innovations is illustrated using the same modulation interface to analyze Special Antarctic Blend (SAB) diesel using 3 s and 9 s modulation periods.
authors.affiliation: Australian Centre for Research on Separation Science, University of Tasmania, Private Bag 75, Hobart, 7001, Australia.
authors.forename: Paul McA
authors.initials: PM
authors.lastname: Harvey
authors.forename: Robert A
authors.initials: RA
authors.lastname: Shellie
authors.forename: Paul R
authors.initials: PR
authors.lastname: Haddad