title: The effect of feature selection methods on computer-aided detection of masses in mammograms.
abstract: In computer-aided diagnosis (CAD) research, feature selection methods are often used to improve generalization performance of classifiers and shorten computation times. In an application that detects malignant masses in mammograms, we investigated the effect of using a selection criterion that is similar to the final performance measure we are optimizing, namely the mean sensitivity of the system in a predefined range of the free-response receiver operating characteristics (FROC). To obtain the generalization performance of the selected feature subsets, a cross validation procedure was performed on a dataset containing 351 abnormal and 7879 normal regions, each region providing a set of 71 mass features. The same number of noise features, not containing any information, were added to investigate the ability of the feature selection algorithms to distinguish between useful and non-useful features. It was found that significantly higher performances were obtained using feature sets selected by the general test statistic Wilks' lambda than using feature sets selected by the more specific FROC measure. Feature selection leads to better performance when compared to a system in which all features were used.
authors.affiliation: Department of Radiology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. a.hupse@rad.umcn.nl
authors.forename: Rianne
authors.initials: R
authors.lastname: Hupse
authors.forename: Nico
authors.initials: N
authors.lastname: Karssemeijer
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging; D016208:Databases, Factual; D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D006801:Humans; D008327:Mammography / Q000379:methods*; D012372:ROC Curve; D015203:Reproducibility of Results