The impact of CCL3L1 copy number in an HIV-1-infected white population.
We examined the effect of CCL3L1 gene copy number on disease progression in a North American white cohort of HIV-1-infected individuals. Although CCL3L1 copy number is enriched in uninfected Caucasians, in HIV-1-infected individuals CCL3L1 copy number did not correlate either with long-term nonprogression or with CD4 cell count or viral load in chronic progressors. These findings underscore the heterogeneity of factors involved with long-term nonprogression when comparing cohorts of varying ethnic backgrounds.
Lee
Erika Y
EY
Department of Immunology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
Yue
Feng Y
FY
Jones
Richard B
RB
Lo
Calvin
C
Sheth
Prameet
P
Hyrcza
Martin D
MD
Kovacs
Colin
C
Benko
Erika
E
Kaul
Rupert
R
Ostrowski
Mario
M
D018791:CD4 Lymphocyte Count; D019742:Chemokines, CC / Q000235:genetics*; D018450:Disease Progression; D018628:Gene Dosage; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D019562:Viral Load; D044465:White People / Q000235:genetics*
C492767:CCL3L1 protein, human; D019742:Chemokines, CC