title: Cytologic follow-up in patients with CIN treated by LLETZ, Cold knife Conization and Semm's cold coagulation.
abstract: Management of cervical premalignant lesions starts with abnormal Pap smear. Regular screening of asymptomatic women (the Pap smear) allows us to diagnose and treat preinvasive lesions before they progress to cervical cancer. There is a wide variety of ablative and destructive methods used in treatment of cervical premalignant lesions. In this study we have compared follow-up cytology results in patient groups treated by LLETZ (Large Loop Excision of the Transformation Zone), Cold Knife Conization (CKC) and Semm's cold coagulation (Electrocoagulation, ECG) according to CIN on target biopsy specimen, and definite therapeutic approach according to patient age, parity and lesion grading. The aim was to evaluate therapeutic success in all three patient groups on the basis of control cytology findings. Normal cytology findings after treatment were recorded in 43 women in LLETZ group (88%), 22 women in CKC group (73%) and in 22 women from the Semm's cold coagulation group (73%). The importance of the use of diagnostic and therapeutic guidelines and regular follow up is emphasized, bearing in mind primarily the young female population with severe preinvasive lesions of uterine cervix. Treating cervical preinvasive lesions offers an excellent opportunity to prevent the occurrence of cervical cancer in the large majority of women with abnormal cervical smears.
authors.affiliation: Clinic for Obstetrics and Gynecology, University Hospital "Sestre Milosrdnice", Zagreb, Croatia. dr.goran.grubisic@gmail.com
authors.forename: Goran
authors.initials: G
authors.lastname: Grubisić
authors.forename: Biserka
authors.initials: B
authors.lastname: Vukosavić-Cimić
authors.forename: Zdenko
authors.initials: Z
authors.lastname: Kraljević
authors.forename: Ahmed
authors.initials: A
authors.lastname: Pirkić
authors.forename: Ivan
authors.initials: I
authors.lastname: Grbavac
authors.forename: Ivan
authors.initials: I
authors.lastname: Bolanca
mesh_terms: D000328:Adult; D001706:Biopsy; D003127:Colposcopy / Q000379:methods*; D003452:Cryosurgery / Q000379:methods; D004564:Electrocoagulation / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D065006:Papanicolaou Test; D011230:Precancerous Conditions / Q000473:pathology / Q000601:surgery*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*; D014626:Vaginal Smears; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery*