title: A pH-responsive fluorescence probe and photosensitiser based on a tetraamino silicon(IV) phthalocyanine.
abstract: A novel tetraamino silicon(iv) phthalocyanine has been prepared, of which the fluorescence emission and reactive oxygen species generation efficiency are greatly enhanced at lower pH in the range of ca. 5-7, making it a promising pH-controlled and tumour-selective fluorescence probe and photosensitiser for photodynamic therapy.
authors.affiliation: Department of Chemistry and Centre of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
authors.forename: Xiong-Jie
authors.initials: XJ
authors.lastname: Jiang
authors.forename: Pui-Chi
authors.initials: PC
authors.lastname: Lo
authors.forename: Sin-Lui
authors.initials: SL
authors.lastname: Yeung
authors.forename: Wing-Ping
authors.initials: WP
authors.lastname: Fong
authors.forename: Dennis K P
authors.initials: DK
authors.lastname: Ng
mesh_terms: D000588:Amines / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D054833:Isoindoles; D008113:Liver Neoplasms / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D017655:Silicon Compounds / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology
chemical_list: D000588:Amines; D005456:Fluorescent Dyes; D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species; D017655:Silicon Compounds; C013647:phthalocyanine