title: Antimicrobial coumarins from the stem bark of Afraegle paniculata.
abstract: Eight compounds were isolated from the stem bark of the plant Afraegle paniculata. One of them, a dimethyl ether of S-trans-marmin (1), is reported as a new natural product. The structures were determined by comprehensive analyses of their 1D and 2D NMR spectroscopic and HREIMS data. The remaining seven known compounds, identified by comparing their spectroscopic data with those reported in the literature, were S-trans-marmin (2), psoralene (3), bergaptene (4), imperatorin (5), 2-(4-hydroxy-3,5-dimethoxyphenyl)-3-hydroxymethyl-2,3-dihydro- 1,4,5-trioxaphenanthren-6-one (6), xanthoxyletin (7), and beta-sitosterol glucopyranoside. Preliminary studies indicated that compounds 2, 3, 5, and 7 showed potent antibacterial, fungicidal, and algicidal properties, while 6 showed only moderate algicidal property.
authors.affiliation: Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon.
authors.forename: Valerie Beatrice
authors.initials: VB
authors.lastname: Tsassi
authors.forename: Hidayat
authors.initials: H
authors.lastname: Hussain
authors.forename: Bouberte Yemele
authors.initials: BY
authors.lastname: Meffo
authors.forename: Simeon F
authors.initials: SF
authors.lastname: Kouam
authors.forename: Etienne
authors.initials: E
authors.lastname: Dongo
authors.forename: Barbara
authors.initials: B
authors.lastname: Schulz
authors.forename: Ivan R
authors.initials: IR
authors.lastname: Greene
authors.forename: Karsten
authors.initials: K
authors.lastname: Krohn
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry; D027821:Rutaceae / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003374:Coumarins