[Changes in the psycho-emotional state under conditions of suppressed immunogenesis, the correction of the disorders with GABA-positive means].
Behaviour and immune responses of rats and mice following cyclophosphamide administration were investigated. The psycho-immunomodulating effect of the GABAergic compounds was revealed. Phenibut (25 mg/kg) and Baclophen (10 mg/kg) restored functional activity of immune system and corrected disturbances of the behavioural responses. The GABAergic agents restored horizontal and direction investigation activities in the rats and mice, decreased grooming and increased number of passages through central zones in the "Suok" test.
Samotrueva
M A
MA
Teplyĭ
D L
DL
Tiurenkov
I N
IN
Luzhnova
S A
SA
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003520:Cyclophosphamide / Q000494:pharmacology; D004644:Emotions / Q000187:drug effects*; D005260:Female; D018755:GABA Agonists / Q000494:pharmacology*; D006120:Grooming / Q000187:drug effects; D007109:Immunity / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D018755:GABA Agonists; D005680:gamma-Aminobutyric Acid; D003520:Cyclophosphamide; D001418:Baclofen; C008842:4-amino-3-phenylbutyric acid