Nanoparticles as a potential cause of pleural and interstitial lung disease.
Nanotechnology holds the promise of revolutionizing our society, bringing numerous beneficial innovations to improve structural materials, electronics, energy, medical imaging, and drug delivery, among other applications. However, nanomaterials present potential safety concerns, and there is accumulating evidence to suggest that nanoparticles may exert adverse effects on the lung and other organ systems. This article will overview the potential risks of engineered nanoparticles and nanotechnology on the respiratory system and highlight recent findings related to pulmonary and systemic effects of inhaled nanoparticles. Special emphasis will be given to carbon nanotubes and the possibility that these nanoparticles could represent an emerging risk for environmental and occupational lung disease, especially in individuals with pre-existing respiratory diseases such as asthma.
Bonner
James C
JC
Department of Environmental and Molecular Toxicology, Campus Box 7633, Raleigh, NC 27695-7633, USA. james_bonner@ncsu.edu
D001249:Asthma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D019570:Inhalation Exposure / Q000009:adverse effects*; D017563:Lung Diseases, Interstitial / Q000209:etiology* / Q000473:pathology; D053758:Nanoparticles / Q000009:adverse effects*; D036103:Nanotechnology; D010995:Pleural Diseases / Q000209:etiology* / Q000473:pathology