title: Real-time contrast-enhanced ultrasound imaging of focal liver lesions in fatty liver.
abstract: OBJECTIVE
  The objective of this study was to investigate the contrast-enhanced ultrasound (CEUS) imaging features of focal liver lesions (FLLs) in fatty liver.
  
  
  METHODS
  One hundred FLLs in 98 patients with fatty liver were evaluated with real-time CEUS.
  
  
  RESULTS
  All malignant FLLs showed hyperenhancement in arterial phase and contrast washout in portal and late phases. Among the FLLs, 3.3% of hemangiomas, 12.5% of focal nodular hyperplasias (FNHs), and 2.5% of focal fatty sparing lesions showed contrast washout in the late phase. The sensitivity and specificity for the characterization of hepatocellular carcinoma, metastasis, hemangioma, FNH, and focal fatty sparing lesions were 100% and 95.6%, 60% and 100%, 93.3% and 98.6%, 87.5% and 97.8%, and 92.6% and 100%, respectively.
  
  
  CONCLUSIONS
  Correct characterization of FLLs in fatty liver by CEUS is possible based on their typical enhancement patterns.
authors.affiliation: Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.
authors.forename: Guang-Jian
authors.initials: GJ
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Xie
authors.forename: Hui-Xiong
authors.initials: HX
authors.lastname: Xu
authors.forename: Zuo-Feng
authors.initials: ZF
authors.lastname: Xu
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Zheng
authors.forename: Jin-Yu
authors.initials: JY
authors.lastname: Liang
authors.forename: Fuminori
authors.initials: F
authors.lastname: Moriyasu
authors.forename: Ming-De
authors.initials: MD
authors.lastname: Lu
mesh_terms: D000328:Adult; D000368:Aged; D003199:Computer Systems; D003287:Contrast Media; D005234:Fatty Liver / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications / Q000000981:diagnostic imaging*; D008297:Male; D045423:Microbubbles; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013459:Sulfur Hexafluoride; D014463:Ultrasonography / Q000379:methods*; D055815:Young Adult
chemical_list: D003287:Contrast Media; D013459:Sulfur Hexafluoride