title: [Association of vascular endothelial growth factor 936C/T polymorphism and the susceptibility to colorectal adenoma].
abstract: OBJECTIVE
  To examine the association between polymorphism of vascular endothelial growth factor(VEGF)1498 C/T,936 C/T and colorectal adenoma genetic susceptibility.
  
  
  METHODS
  A case-control study of 224 colorectal adenomas and 200 controls was conducted and VEGF genotypes were determined based on TaqMan-probe assay. The epidemiological factors were collected through questionnaire. Accordingly, the clinicopathological data of each sample were also investigated.
  
  
  RESULTS
  The carriage of 936 CT and CT+TT genotypes had significantly higher risk of colorectal adenoma (CT vs. CC, OR=2.00, 95% CI: 1.23-3.25, P=0.006; CT+TT vs. CC, OR=2.04, 95% CI:1.28-3.26, P=0.003). 936-T allele carriage had increased risk of colorectal adenoma (OR=1.91, 95% CI:1.25-2.91, P=0.003). The genotypes of 1498 C/T and the frequency of C/T allele showed no differences between healthy persons and patients (P>0.05). In patients with 936 CT+TT and 936-T allele implied a tendency of villous adenoma category (CT+TT vs. CC, OR=2.54, 95% CI:1.12-5.75, P=0.040; T allele vs. C allele, OR=3.08, 95% CI, 1.64-5.80, P=0.001).
  
  
  CONCLUSIONS
  VEGF 936 C/T polymorphism can influence susceptibility to colorectal adenoma.
authors.affiliation: Department of General Surgery, Zhongnan Hospital of Wuhan University, Wuhan 430071, China.
authors.forename: Xiang-lei
authors.initials: XL
authors.lastname: Wu
authors.forename: Dong-qing
authors.initials: DQ
authors.lastname: Li
authors.forename: Zhi-su
authors.initials: ZS
authors.lastname: Liu
authors.forename: Xin-yue
authors.initials: XY
authors.lastname: Wan
authors.forename: Yun-hua
authors.initials: YH
authors.lastname: Wu
authors.forename: Cong-qing
authors.initials: CQ
authors.lastname: Jiang
authors.forename: Zhong-lin
authors.initials: ZL
authors.lastname: Zhang
authors.forename: Qian-bo
authors.initials: QB
authors.lastname: Qin
authors.forename: Qun
authors.initials: Q
authors.lastname: Qian
mesh_terms: D000236:Adenoma / Q000235:genetics*; D000328:Adult; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A