Emerging analytical separation techniques with high-throughput potential for pharmaceutical analysis, part II: Novel chromatographic modes.
In this review paper, the high-throughput potential of some novel chromatographic modes is surveyed. The modes are Hydrophilic Interaction Liquid Chromatography (HILIC), Supercritical Fluid Chromatography (SFC), and Polar Organic Solvent Chromatography (POSC). Their high throughput potential will be discussed in three domains, i.e. drug discovery, bio-analysis in clinical drug development, and quality control (QC) testing, and is illustrated with some examples.
Dejaegher
Bieke
B
Department of Analytical Chemistry and Pharmaceutical Technology, Vrije Universiteit Brussel, Laarbeeklaan 103, Brussels, Belgium.
Pieters
Sigrid
S
Vander Heyden
Yvan
Y
D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods*; D015195:Drug Design; D057166:High-Throughput Screening Assays / Q000295:instrumentation / Q000379:methods*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011786:Quality Control
D004364:Pharmaceutical Preparations