title: BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia.
abstract: Brain-derived neurotrophic factor (BDNF) gene variants may potentially influence behaviour. In order to test this hypothesis, we investigated the relationship between BDNF Val66Met polymorphism and aggressive behaviour in a population of schizophrenic patients. Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour.
authors.affiliation: IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardetina, 306, 00179 Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Spalletta
authors.forename: D W
authors.initials: DW
authors.lastname: Morris
authors.forename: F
authors.initials: F
authors.lastname: Angelucci
authors.forename: I A
authors.initials: IA
authors.lastname: Rubino
authors.forename: I
authors.initials: I
authors.lastname: Spoletini
authors.forename: P
authors.initials: P
authors.lastname: Bria
authors.forename: G
authors.initials: G
authors.lastname: Martinotti
authors.forename: A
authors.initials: A
authors.lastname: Siracusano
authors.forename: G
authors.initials: G
authors.lastname: Bonaviri
authors.forename: S
authors.initials: S
authors.lastname: Bernardini
authors.forename: C
authors.initials: C
authors.lastname: Caltagirone
authors.forename: P
authors.initials: P
authors.lastname: Bossù
authors.forename: G
authors.initials: G
authors.lastname: Donohoe
authors.forename: M
authors.initials: M
authors.lastname: Gill
authors.forename: A P
authors.initials: AP
authors.lastname: Corvin
mesh_terms: D000328:Adult; D000374:Aggression / Q000523:psychology*; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008715:Methionine; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D014633:Valine
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D008715:Methionine; D014633:Valine