MyoD, a lesson in widespread DNA binding.
There is growing recognition that animal transcription factors bind in vivo to far more genomic regions than generally assumed earlier. In this issue of Developmental Cell, Cao et al. show that the muscle specification factor MyoD binds to regions near most genes and modifies chromatin states at these sites.
Biggin
Mark D
MD
Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.