Maternal serum triglycerides as predictive factors for large-for-gestational age newborns in women with gestational diabetes mellitus.
OBJECTIVE
To determine the contribution of maternal lipids in predicting large-for-gestational age (LGA) newborns born to women with gestational diabetes mellitus (GDM).


METHODS
Retrospective study.


METHODS
Yonsei University Health System, Korea.


METHODS
A total of 104 women diagnosed with GDM between January 2000 and June 2008.


METHODS
Women who were positive on the 50 g oral glucose challenge test (24-28 weeks' gestation) and who were referred patients suspected of GDM underwent a 3 hours, 100 g oral glucose tolerance test for GDM diagnosis. Maternal fasting serum triglycerides and total, high-density lipoprotein (HDL), and low-density lipoprotein cholesterol levels were determined at 24-32 weeks' gestation. Logistic regression analysis was performed to determine maternal parameters independently associated with delivering LGA newborns at term.


METHODS
Risk contributions for LGA newborns.


RESULTS
Maternal fasting serum triglyceride levels were significantly higher in mothers of LGA newborns compared with other mothers; however, no significant correlations were found between newborn birthweight and maternal fasting glucose, total cholesterol, or HDL cholesterol levels. After adjusting for confounding variables including prepregnancy body mass index, weight gain during pregnancy, age, and parity, maternal hypertriglyceridemia at 24-32 weeks' gestation remained an independent parameter for identifying term LGA newborns.


CONCLUSIONS
In GDM pregnancies, determining maternal serum triglyceride levels during midpregnancy may help identify women likely to give birth to LGA newborns.
Son
Ga Hyun
GH
Department of Obstetrics and Gynecology, Yonsei University Health System, 134 Shinchon-dong Seodaemun-gu, Seoul, Korea.
Kwon
Ja Young
JY
Kim
Young Han
YH
Park
Yong Won
YW
D001724:Birth Weight; D001786:Blood Glucose / Q000378:metabolism; D015331:Cohort Studies; D015897:Comorbidity; D016640:Diabetes, Gestational / Q000097:blood* / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005320:Fetal Macrosomia / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000453:epidemiology*; D005500:Follow-Up Studies; D005865:Gestational Age; D005951:Glucose Tolerance Test; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007333:Insulin Resistance; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D011336:Probability; D012189:Retrospective Studies; D018570:Risk Assessment; D014280:Triglycerides / Q000097:blood*; D016216:Ultrasonography, Prenatal
D001786:Blood Glucose; D014280:Triglycerides