Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes.
Epigenetic control is an important aspect of gene regulation. Despite detailed understanding of protein-coding gene expression, the transcription of noncoding RNA genes by RNA polymerase III (Pol III) is less well characterized. Here we profile the epigenetic features of Pol III target genes throughout the human genome. This reveals that the chromatin landscape of Pol III-transcribed genes resembles that of Pol II templates in many ways, although there are also clear differences. Our analysis also uncovered an entirely unexpected phenomenon: namely, that Pol II is present at the majority of genomic loci that are bound by Pol III.
Barski
Artem
A
Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
Chepelev
Iouri
I
Liko
Dritan
D
Cuddapah
Suresh
S
Fleming
Alastair B
AB
Birch
Joanna
J
Cui
Kairong
K
White
Robert J
RJ
Zhao
Keji
K
D001665:Binding Sites; D002460:Cell Line; D002843:Chromatin / Q000235:genetics; D004257:DNA Polymerase II / Q000235:genetics* / Q000378:metabolism; D044127:Epigenesis, Genetic; D015870:Gene Expression; D005796:Genes; D056426:Genetic Loci; D015894:Genome, Human; D006801:Humans; D012320:RNA Polymerase III / Q000032:analysis / Q000235:genetics* / Q000378:metabolism
D002843:Chromatin; D012320:RNA Polymerase III; D004257:DNA Polymerase II