Age-related up-regulation of beta3-adrenergic receptor in heart-failure rats.
Stimulation of beta1- and beta2-adrenergic receptors (ARs) in the heart results in positive inotropy. In contrast, it has been reported that the beta3-AR is also expressed in the heart and that its stimulation leads to negative inotropic effects. The aim of this study was to investigate the expression of beta3-AR in age-related heart-failure rats and its relevance to left ventricular dysfunction. Aging male Wistar rats were divided into young and aging groups according to age, and each group included sham-operation and heart-failure subgroups. Left ventricular end-diastolic pressure (LVEDP) and the ratio of left ventricular weight to body weight (LV/BW) were significantly higher for the aging heart-failure versus young heart-failure and the heart-failure versus sham-operation groups (P < 0.01, respectively). However, the left ventricular end-systolic pressure (LVESP) and the maximal rate of rise or fall of left ventricular pressure were all significantly lower for the aging heart-failure versus young heart-failure and the heart-failure versus sham-operation groups (P < 0.01, respectively). beta3-AR protein levels increased significantly when heart failure worsened in aging rats. These results suggest that beta3-AR expression in age-related heart-failure rats and left ventricular function were highly correlated.
Chen
Zhe
Z
Department of Internal Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China.
Miao
Guobin
G
Liu
Miaobing
M
Hao
Gang
G
Liu
Yingying
Y
Fang
Xiangyang
X
Zhang
Zhiyong
Z
Lu
Lingqiao
L
Zhang
Jianjun
J
Zhang
Lin
L
D000375:Aging / Q000235:genetics* / Q000473:pathology; D000818:Animals; D001835:Body Weight / Q000502:physiology; D006333:Heart Failure / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D008297:Male; D009206:Myocardium / Q000473:pathology; D009929:Organ Size / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics* / Q000378:metabolism; D013997:Time Factors; D015854:Up-Regulation / Q000235:genetics*
D012333:RNA, Messenger; D022702:Receptors, Adrenergic, beta-3