title: Cutaneous acanthamebiasis infection in immunocompetent and immunocompromised patients.
abstract: BACKGROUND
  Cutaneous acanthamebiasis is a rare infection and few patients have been reported worldwide.
  
  
  METHODS
  Observational and descriptive study carried out from March 1996 to February 2006 in patients with diagnosis of cutaneous free-living amebic infection caused by Acanthamoeba spp. The patients were diagnosed at the Dos de Mayo National Hospital (Lima-Peru) where skin biopsies, histopathologic studies and cultures were performed. The clinical and epidemiologic characteristics, diagnosis, treatment and evolution were recorded in a survey.
  
  
  RESULTS
  Five patients with cutaneous free-living amebic infection caused by Acanthamoeba spp. were identified. Skin lesions were ulceronecrotic (four patients), an infiltrative bluish plaque (one patient), and a periorbital tumor (one patient). Three patients were positive for human immunodeficiency virus (HIV), had only cutaneous involvement, and died of opportunistic infections. The two immunocompetent patients developed Acanthamoeba granulomatous encephalitis and meningoencephalitis that progressed to intracranial hypertension and death.
  
  
  CONCLUSIONS
  The clinical manifestations of cutaneous free-living amebic infection caused by Acanthamoeba spp. appear to vary according to the underlying immunologic status.
authors.affiliation: Instituto de Investigaciones Clinicas de la Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Peru.
authors.forename: Carlos
authors.initials: C
authors.lastname: Galarza
authors.forename: Willy
authors.initials: W
authors.lastname: Ramos
authors.forename: Ericson L
authors.initials: EL
authors.lastname: Gutierrez
authors.forename: Gerardo
authors.initials: G
authors.lastname: Ronceros
authors.forename: Maria
authors.initials: M
authors.lastname: Teran
authors.forename: Martha
authors.initials: M
authors.lastname: Uribe
authors.forename: Marcos
authors.initials: M
authors.lastname: Navincopa
authors.forename: Alex G
authors.initials: AG
authors.lastname: Ortega-Loayza
mesh_terms: D000048:Acanthamoeba; D000328:Adult; D000562:Amebiasis / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007121:Immunocompetence; D016867:Immunocompromised Host; D008297:Male; D012876:Skin Diseases, Parasitic / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology