Corneal infiltrates after corneal collagen cross-linking.
OBJECTIVE
To present a case of advancing keratoconus treated with corneal collagen cross-linking (CXL) with ultraviolet A (UVA) light and riboflavin complicated with sterile infiltrates.


METHODS
The patient's cornea was de-epithelialized and CXL was performed with application of riboflavin and exposure to UVA light (370 nm, 3 mW/cm2) for 30 minutes.


RESULTS
Early in the postoperative period, the patient presented with 11 deep stromal infiltrates of 1 to 2 mm with clear demarked edges in a circle near the limbus with some clear cornea. Corneal cultures were negative. Treatment consisted of antibiotic ofloxacin and tobramycin four times daily, and dexamethasone drops six times daily. After 2 months, scars remained evident.


CONCLUSIONS
This complication has not been reported previously and may be an individual hypersensitivity reaction to the riboflavin or UVA light in the anterior stroma.
Mangioris
George F
GF
Aristotle University of Thessaloniki and A' University Eye-Clinic, AHEPA Hospital, Thessaloniki, Greece.
Papadopoulou
Domniki N
DN
Balidis
Miltiadis O
MO
Poulas
Jordan L
JL
Papadopoulos
Nikolaos Th
NT
Seiler
Theo
T
D000328:Adult; D003094:Collagen / Q000378:metabolism*; D003316:Corneal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D003319:Corneal Stroma / Q000378:metabolism*; D003432:Cross-Linking Reagents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007640:Keratoconus / Q000188:drug therapy / Q000378:metabolism; D015242:Ofloxacin / Q000627:therapeutic use; D017319:Photosensitizing Agents / Q000009:adverse effects; D011183:Postoperative Complications; D012256:Riboflavin / Q000009:adverse effects; D014031:Tobramycin / Q000627:therapeutic use; D014466:Ultraviolet Rays
D003432:Cross-Linking Reagents; D017319:Photosensitizing Agents; D003094:Collagen; D015242:Ofloxacin; D012256:Riboflavin; D014031:Tobramycin