Antiretroviral adherence interventions: translating research findings to the real world clinic.
The success of potent combination antiretroviral therapy (ART) for HIV infection is compromised primarily by failure to maintain optimal levels of adherence over the long term. Recent reviews suggest behavioral interventions to promote ART adherence can have significant effects, but these tend to be small and to diminish over time; sustained improvements in biomarkers are particularly elusive. In this article, we update current reviews, focusing specifically on the 13 studies evaluating behavioral interventions to promote ART adherence published since September 2007. We describe the range of intervention strategies employed and qualitatively summarize findings of their efficacy. In conclusion, we consider implications and offer strategies for enhancing adherence in clinic-based HIV care prior to ART initiation, at initiation, and over the course of treatment.
Simoni
Jane M
JM
Department of Psychology, University of Washington, Campus Box 351525, Seattle, WA, 98195-1525, USA. jsimoni@uw.edu
Amico
K Rivet
KR
Smith
Laramie
L
Nelson
Kimberly
K
D019380:Anti-HIV Agents / Q000627:therapeutic use*; D001521:Behavior Therapy / Q000379:methods*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D055118:Medication Adherence / Q000523:psychology*; D010353:Patient Education as Topic / Q000379:methods; D011320:Primary Health Care / Q000458:organization & administration
D019380:Anti-HIV Agents