Release of N-terminal pro-brain natriuretic peptide in children with acute rheumatic carditis.
BACKGROUND
Acute rheumatic carditis is still an important cause of cardiac failure in developing countries. B-type natriuretic peptides, especially N-terminal segment of its prohormone are now recognised as essential parts of cardiologic evaluation. Increased plasma concentrations of B-type natriuretic peptide and its prohormone are markers of cardiac failure and hypoxia in adults.


OBJECTIVE
To measure the prohormone levels in children with acute rheumatic carditis and to determine whether its concentrations correlate with clinical and laboratory findings.


METHODS
A total of 24 children with acute rheumatic carditis and 23 age and sex-matched healthy subjects were entered in the study. Transthoracic echocardiography was performed in all patients to assess the severity of the valve insufficiency and cardiac dysfunction. The prohormone plasma levels were tested for correlation with cardiac dysfunction and other biochemical markers, such as C-reactive protein, erythrocyte sedimentation rate, and anti-streptolysin-O titter.


RESULTS
The prohormone plasma concentrations were significantly higher in children with acute rheumatic carditis than in control subjects at the time of diagnosis. A significant decrease of the plasma level was detected among patients after treatments (6-8 weeks).


CONCLUSIONS
We found increased plasma prohormone levels in children with acute rheumatic carditis in the acute stage of illness compared with healthy subjects. Another result is increased plasma prohormone levels as acute rheumatic carditis are reversible.
Cimen
Omer
O
Department of Paediatrics, Selçuk University, Konya, Turkey.
Oran
Bülent
B
Cimen
Derya
D
Baysal
Tamer
T
Karaaslan
Sevim
S
Unal
Ekrem
E
Başarili
Kemal
K
Büyükbaş
Sadik
S
D000208:Acute Disease; D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000097:blood / Q000209:etiology; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000209:etiology; D007118:Immunoassay; D008297:Male; D009205:Myocarditis / Q000097:blood* / Q000150:complications; D020097:Natriuretic Peptide, Brain / Q000096:biosynthesis*; D010446:Peptide Fragments / Q000096:biosynthesis*; D011379:Prognosis; D011498:Protein Precursors; D012189:Retrospective Studies; D012214:Rheumatic Heart Disease / Q000097:blood* / Q000150:complications
D015415:Biomarkers; D010446:Peptide Fragments; D011498:Protein Precursors; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain