IL-33 and IL-33 receptors in host defense and diseases.
Interleukin-33 (IL-33) is a member of the IL-1 cytokine family, which includes IL-1 and IL-18. IL-33 is considered to be crucial for induction of Th2-type cytokine-associated immune responses such as host defense against nematodes and allergic diseases by inducing production of such Th2-type cytokines as IL-5 and IL-13 by Th2 cells, mast cells, basophils and eosinophils. In addition, IL-33 is involved in the induction of non-Th2-type acute and chronic inflammation as a proinflammatory cytokine, similar to IL-1 and IL-18. In this review, we summarize and discuss the current knowledge regarding the roles of IL-33 and IL-33 receptors in host defense and disease development.
Oboki
Keisuke
K
Department of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, Japan.
Ohno
Tatsukuni
T
Kajiwara
Naoki
N
Saito
Hirohisa
H
Nakae
Susumu
S
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D054884:Host-Pathogen Interactions; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics / Q000276:immunology*; D007109:Immunity; D007239:Infections / Q000235:genetics / Q000276:immunology*; D007249:Inflammation; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D007378:Interleukins / Q000276:immunology*; D051379:Mice; D011110:Polymorphism, Genetic; D011956:Receptors, Cell Surface / Q000276:immunology; D018123:Receptors, Interleukin / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology
C079241:IL1RL1 protein, human; C506536:IL33 protein, human; C486189:Il1rl1 protein, mouse; D000072179:Interleukin-1 Receptor-Like 1 Protein; D000067596:Interleukin-33; D007378:Interleukins; D011956:Receptors, Cell Surface; D018123:Receptors, Interleukin; D051193:Toll-Like Receptors