title: Tuning the electronic properties of dppz-ligands and their palladium(II) complexes.
abstract: New organometallic palladium complexes of the general type [(RR'dppz)Pd(Me)L](n+) (RR'dppz = derivatives of dipyrido[3,2-a:2',3'-c]phenazine with RR' = 11-Cl, 11,12-Cl(2), 11-CF(3), 11-NO(2), 11-NH(2); L = Cl, 1-methyluracilate (n = 0), pyridine, cytosine, caffeine, or 1-methylcytosine, (all n = 1) were characterised and studied in detail by electrochemical and spectroscopic (NMR, UV/Vis- absorption and emission) methods. EPR spectroscopy and density functional calculations reveal markedly tuneable lowest unoccupied molecular orbitals (LUMO) located at the dppz ligands. Cytotoxicity experiments on HT-29 colon carcinoma and MCF-7 breast cancer cell lines show promising activities for selected compounds.
authors.affiliation: Universität zu Köln, Institut für Anorganische Chemie, Greinstrasse 6, D-50969, Köln, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Butsch
authors.forename: Ronald
authors.initials: R
authors.lastname: Gust
authors.forename: Axel
authors.initials: A
authors.lastname: Klein
authors.forename: Ingo
authors.initials: I
authors.lastname: Ott
authors.forename: Marco
authors.initials: M
authors.lastname: Romanski
mesh_terms: D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry* / Q000633:toxicity; D018360:Crystallography, X-Ray; D055664:Electrochemical Techniques; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010165:Palladium / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D008024:Ligands; D010165:Palladium