title: Assessment of COPD severity by computed tomography: correlation with lung functional testing.
abstract: CT scans of 474 patients with suspected chronic obstructive pulmonary disease (COPD) were retrospectively evaluated by automated software. There was a correlation between the total lung capacity (TLC) and the total lung volume (TLV) (r=.675, P<.001), between the TLC and the total emphysema volume (r=.571, P<.001), as well as between the TLC and the emphysema index (r=.532, P<.001), respectively. The correlation between the TLC and the TLV was dependent on the COPD severity according to the Global Initiative for Chronic Obstructive Lung Disease classification (chi(2)=6.3079, P=.043). The TLC allows a prediction of clinical illness severity.
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospitals Ulm, Ulm, Germany. sandra.pauls@uni-ulm.de <sandra.pauls@uni-ulm.de>
authors.forename: Sandra
authors.initials: S
authors.lastname: Pauls
authors.forename: Daniel
authors.initials: D
authors.lastname: Gulkin
authors.forename: Sebastian
authors.initials: S
authors.lastname: Feuerlein
authors.forename: Rainer
authors.initials: R
authors.lastname: Muche
authors.forename: Stefan
authors.initials: S
authors.lastname: Krüger
authors.forename: Stefan Andreas
authors.initials: SA
authors.lastname: Schmidt
authors.forename: Ekta
authors.initials: E
authors.lastname: Dharaiya
authors.forename: Hans-Jürgen
authors.initials: HJ
authors.lastname: Brambs
authors.forename: Martin
authors.initials: M
authors.lastname: Hetzel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis*; D013902:Radiography, Thoracic / Q000379:methods*; D015203:Reproducibility of Results; D012129:Respiratory Function Tests; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D014057:Tomography, X-Ray Computed / Q000379:methods*; D055815:Young Adult