title: Recurrent inverted papilloma with intracranial and temporal fossa involvement: A case report and review of the literature.
abstract: Inverted papilloma (IP) is a rare nasosinusal benign tumour, with epithelium surface inversion to inside the stroma. Extension to intracranial temporal fossa and middle ear has been reported in few cases in the literature. This involvement may be derived from either direct extension from sinonasal cavity via the Eustachian tube or primary middle ear involvement secondary to metaplastic changes of the middle ear mucosa. Here, we report a case of inverted papilloma in a male patient, with multiple recurrences, middle ear and intracranial involvement into the temporal fossa with posterior development of malignancy. This patient had received multiple surgeries and radiotherapy but despite of that, his disease recurred several times. As a conclusion, inverted papilloma is a benign tumour with an aggressive course, tendency to recurrence and progression to malignancy. Intracranial and temporal fossa involvements are rare and the treatment depends of the symptoms and the severity of the disease.
authors.affiliation: Department of Radiotherapy, Morvan Hospital, CHU de Brest, Brest University, France. catalina.acevedo@hotmail.com <catalina.acevedo@hotmail.com>
authors.forename: C-M
authors.initials: CM
authors.lastname: Acevedo-Henao
authors.forename: M
authors.initials: M
authors.lastname: Talagas
authors.forename: R
authors.initials: R
authors.lastname: Marianowski
authors.forename: O
authors.initials: O
authors.lastname: Pradier
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology / Q000601:surgery; D003131:Combined Modality Therapy; D018450:Disease Progression; D004432:Ear, Middle / Q000473:pathology; D005158:Facial Paralysis / Q000209:etiology; D017809:Fatal Outcome; D006314:Hearing Loss, Conductive / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015508:Nasal Obstruction / Q000209:etiology; D009361:Neoplasm Invasiveness / Q000473:pathology; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D009669:Nose Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D010212:Papilloma / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D010579:Petrous Bone / Q000473:pathology / Q000601:surgery; D020266:Radiotherapy, Conformal; D012086:Reoperation; D013702:Temporal Lobe / Q000473:pathology / Q000601:surgery