Iodine-124: a promising positron emitter for organic PET chemistry.
The use of radiopharmaceuticals for molecular imaging of biochemical and physiological processes in vivo has evolved into an important diagnostic tool in modern nuclear medicine and medical research. Positron emission tomography (PET) is currently the most sophisticated molecular imaging methodology, mainly due to the unrivalled high sensitivity which allows for the studying of biochemistry in vivo on the molecular level. The most frequently used radionuclides for PET have relatively short half-lives (e.g. 11C: 20.4 min; 18F: 109.8 min) which may limit both the synthesis procedures and the time frame of PET studies. Iodine-124 (124I, t1/2 = 4.2 d) is an alternative long-lived PET radionuclide attracting increasing interest for long term clinical and small animal PET studies. The present review gives a survey on the use of 124I as promising PET radionuclide for molecular imaging. The first part describes the production of 124I. The second part covers basic radiochemistry with 124I focused on the synthesis of 124I-labeled compounds for molecular imaging purposes. The review concludes with a summary and an outlook on the future prospective of using the long-lived positron emitter 124I in the field of organic PET chemistry and molecular imaging.
Koehler
Lena
L
Institute of Radiopharmacy, Research Center Dresden-Rossendorf, Dresden, Germany. lenakoehler@googlemail.com
Gagnon
Katherine
K
McQuarrie
Steve
S
Wuest
Frank
F
D000906:Antibodies / Q000737:chemistry; D006207:Half-Life; D006801:Humans; D007457:Iodine Radioisotopes / Q000737:chemistry*; D007553:Isotope Labeling / Q000379:methods*; D009369:Neoplasms / Q000175:diagnosis; D010455:Peptides / Q000737:chemistry; D049268:Positron-Emission Tomography / Q000379:methods*; D011506:Proteins / Q000737:chemistry; D019275:Radiopharmaceuticals / Q000737:chemistry*
D000906:Antibodies; D007457:Iodine Radioisotopes; D010455:Peptides; D011506:Proteins; D019275:Radiopharmaceuticals