title: Willem Dicke. Brilliant clinical observer and translational investigator. Discoverer of the toxic cause of celiac disease.
abstract: We can admire and learn from physicians with acute clinical acumen and superb approaches to translational research. The observations and studies of Dr. Willem Dicke, a Dutch pediatrician, on the toxic effects of a protein component of wheat and rye demonstrate the highest quality of such investigations. From a clinical observation of one child with celiac disease, through years of historical questioning and empirical dietary suggestions of patient families, he concluded that such foods were toxic. When research became possible after the second world war and fecal fat measures as a hard end point became available he studied 5 children in detail to establish the validity of his clinical clues.
authors.affiliation: Collegiate School, New York, New York 10024, USA.
authors.forename: David
authors.initials: D
authors.lastname: Yan
authors.forename: Peter R
authors.initials: PR
authors.lastname: Holt
mesh_terms: D002446:Celiac Disease / Q000178:diet therapy / Q000209:etiology* / Q000266:history; D004032:Diet; D005243:Feces / Q000737:chemistry; D049673:History, 20th Century; D006801:Humans; D057170:Translational Research, Biomedical / Q000266:history; D014908:Triticum / Q000633:toxicity*