title: Anticancer activity of opened arene ruthenium metalla-assemblies.
abstract: Cationic tetranuclear and hexanuclear opened metalla-assemblies incorporating 5,15-bis(4-pyridyl)-10,20-diphenylporphyrin (bpp) or 5,10,15-tris(4-pyridyl)-20-phenylporphyrin (tpp) panels and dinuclear arene ruthenium clips [(p-cymene)(2)Ru(2)(OO[intersection]OO)(2)](2+) (OO[intersection]OO = oxalato, 2,5-dioxydo-1,4-benzoquinonato (dobq)) have been assembled in the presence of silver triflate. All complexes were characterised by NMR, IR and UV-visible spectroscopy and electrospray ionisation mass spectrometry. The cytotoxicities of the tetranuclear and hexanuclear ruthenium complexes have been established on ovarian A2780 and A2780cisR cancer cell lines. The compounds are quite cytotoxic, the most active metalla-assembly being [Ru(6)(p-cymene)(6)(dobq)(3)(tpp)(2)](6+), with IC(50) values of 2.1 microM and 3.8 microM against A2780 and A2780cisR cells, respectively.
authors.affiliation: Institute of Chemistry, University of Neuchatel, 51 Ave de Bellevaux, CH-2000, Neuchatel, Switzerland.
authors.forename: Nicolas P E
authors.initials: NP
authors.lastname: Barry
authors.forename: Olivier
authors.initials: O
authors.lastname: Zava
authors.forename: Julien
authors.initials: J
authors.lastname: Furrer
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Dyson
authors.forename: Bruno
authors.initials: B
authors.lastname: Therrien
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008698:Mesylates / Q000737:chemistry; D008968:Molecular Conformation; D011166:Porphyrins / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008698:Mesylates; D011166:Porphyrins; D012428:Ruthenium; C012077:trifluoromethanesulfonic acid