Synthesis of acyclic nucleosides with a chiral amino side chain by the Mitsunobu coupling reaction.
A novel and efficient synthetic method has been developed for the preparation of chiral acyclic nucleosides with a chiral amino side chain by Mitsunobu reaction between nucleoside bases and protected L-serine. This method suggests a potentially more efficient and complementary process to acquire chiral acyclic nucleosides.
Guo
Hai-Ming
HM
College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, Xinxiang 453007, Henan, China. ghm@htu.cn
Wu
Yan-Yan
YY
Niu
Hong-Ying
HY
Wang
Dong-Chao
DC
Qu
Gui-Rong
GR
D000588:Amines; D008722:Methods; D009705:Nucleosides / Q000138:chemical synthesis*; D055601:Organic Chemistry Phenomena; D012694:Serine
D000588:Amines; D009705:Nucleosides; D012694:Serine