title: [A case of myelodysplastic syndrome with aberrant evolution of chromosome 1 and 11 in 6 years of follow-up].
abstract: This study was aimed to investigate the relationship between cytogenetic evolution and disease progression in patient with MDS-RAEB. By a long term (6 years) follow-up of a patient with MDS-RAEB, peripheral blood cell count, bone marrow cell morphology and conventional cytogenetics were monitored regularly. In addition, fluorescence in situ hybridization (FISH) was applied to confirm the aberrant karyotype. The results indicated that this patient was failed with conventional chemotherapy of AML, but had response to ATRA and 6-MP in the 72 months follow-up. At initial diagnosis, the cytogenetics analysis showed normal karyotype, whereas 46, XY, 2q+[1]/46, XY[19] was found at 48 months, 46, XY, dup(1q)[3]/46, XY[7] at 56 months, and dup (1) as well as der (11) with complex karyotype at 68 months, which was accompanied by progressive decrease of platelet count. It is concluded that karyotype evolution is perhaps associated with progression of MDS.
authors.affiliation: Department of Hematology, Jiangsu Province Hospital, the First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Lü
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Qiu
authors.forename: Hai-Rong
authors.initials: HR
authors.lastname: Qiu
authors.forename: Su-Jiang
authors.initials: SJ
authors.lastname: Zhang
authors.forename: Ji
authors.initials: J
authors.lastname: Xu
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Han-Xin
authors.initials: HX
authors.lastname: Wu
authors.forename: Jian-Yong
authors.initials: JY
authors.lastname: Li
authors.forename: Jing-Zhang
authors.initials: JZ
authors.lastname: Shao
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D005500:Follow-Up Studies; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics*