title: [Diffusion and perfusion magnetic resonance imaging in evaluation of primary glial brain tumors].
abstract: BACKGROUND
  Diffusion (DWI) and perfusion (PWI) imaging can give important data about physiological characteristics of tissue, which complete morphologic findings from conventional MRI. The aim of this study is to estimate the value of these MRI technics in evaluation of primary glial brain tumors.
  
  
  METHODS
  The significance of DWI and PWI in differentiation of histologically proven low- and high-grade gliomas was estimated in 48 patient with diagnosed brain gliomas. ADC and rCBV values were compared by aplication of Mann-Whitney test, and logistic regression analysis was used to determine which of these two parameters contributed the most in increasing the diagnostic accuracy, ia. its sensitivity, specificity and predictive velues. ROC curves were constructed to determine threshold values for differentiation of low- from high-grade lesions.
  
  
  RESULTS
  Statistical significance were showed between mean values of rCBV for low-grade (0.82) and high-grade (5.32) gliomas, which was not found for values of ADC parameters. Threshold rCBV value of 1.23 was determinated for discrimination between low- and high-grade gliomas with a sensitivity of 83.2% and a specificity of 77.5%.
  
  
  CONCLUSIONS
  Conventional MRI combined with PWI increases the accuracy in determination of glioma grade.
authors.affiliation: Centar za radiologiju i magnetnu rezonanciju, KCS, Beograd.
authors.forename: T L
authors.initials: TL
authors.lastname: Stosić-Opinćal
authors.forename: M V
authors.initials: MV
authors.lastname: Macvanski
authors.forename: S S
authors.initials: SS
authors.lastname: Gavrilović
authors.forename: M S
authors.initials: MS
authors.lastname: Gavrilov
authors.forename: D S
authors.initials: DS
authors.lastname: Damjanović
authors.forename: B D
authors.initials: BD
authors.lastname: Vasić
authors.forename: D M
authors.initials: DM
authors.lastname: Grujicić
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005910:Glioma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D055815:Young Adult