title: Effectiveness of varicella vaccine in children infected with HIV.
abstract: Although varicella vaccine is given to clinically stable human immunodeficiency virus (HIV)-infected children, its effectiveness is unknown. We assessed its effectiveness by reviewing the medical records of closely monitored HIV-infected children, including those receiving highly active antiretroviral therapy (HAART) between 1989 and 2007. Varicella immunization and development of varicella or herpes zoster were noted. Effectiveness was calculated by subtracting from 1 the rate ratios for the incidence rates of varicella or herpes zoster in vaccinated versus unvaccinated children. The effectiveness of the vaccine was 82% (95% confidence interval [CI], 24%-99%; P = .01) against varicella and was 100% (95% CI, 67%-100%; P < .001) against herpes zoster. When the analysis was controlled for receipt of HAART, vaccination remained highly protective against herpes zoster.
authors.affiliation: Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
authors.forename: Moeun
authors.initials: M
authors.lastname: Son
authors.forename: Eugene D
authors.initials: ED
authors.lastname: Shapiro
authors.forename: Philip
authors.initials: P
authors.lastname: LaRussa
authors.forename: Natalie
authors.initials: N
authors.lastname: Neu
authors.forename: David E
authors.initials: DE
authors.lastname: Michalik
authors.forename: Michelle
authors.initials: M
authors.lastname: Meglin
authors.forename: Andrea
authors.initials: A
authors.lastname: Jurgrau
authors.forename: Wally
authors.initials: W
authors.lastname: Bitar
authors.forename: Marietta
authors.initials: M
authors.lastname: Vasquez
authors.forename: Patricia
authors.initials: P
authors.lastname: Flynn
authors.forename: Anne A
authors.initials: AA
authors.lastname: Gershon
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D002644:Chickenpox / Q000453:epidemiology* / Q000517:prevention & control; D019433:Chickenpox Vaccine / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology*; D006562:Herpes Zoster / Q000453:epidemiology* / Q000517:prevention & control; D006801:Humans; D008297:Male
chemical_list: D019380:Anti-HIV Agents; D019433:Chickenpox Vaccine