Codon usage biases in Alzheimer's disease and other neurodegenerative diseases.
Establishing codon usage biases are crucial for understanding the etiology of central nervous system neurodegenerative diseases (CNSNDD) especially Alzheimer's disease (AD) as well as genetic factors. G and C ending codons are strongly biased in the coding sequences of these proteins as a result of genomic GC composition constraints. On the other hand, codons that identified as translationally optimal in the major trend all end in C or G, suggesting translational selection should also be taken into consideration additional to compositional constraints. Furthermore, this investigation reveals that three common codons, CGC (Arg), AGC (Ser), and GGC (Gly), are also critical in affecting codon usage bias. They not only can offer an insight into the codon usage bias of AD and its mechanism, but also may help in the possible cures for these diseases.
Yang
Jie
J
State Key Laboratory of Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University, Nanjing 210093, China. yangjie@nju.edu.cn
Zhu
Tong-Yang
TY
Jiang
Zheng-Xin
ZX
Chen
Cheng
C
Wang
Yue-Lan
YL
Zhang
Song
S
Jiang
Xiong-Fei
XF
Wang
Ting-Ting
TT
Wang
Lin
L
Xia
Wen-Hao
WH
Li
Lei
L
Chen
Ji-Jun
JJ
Wang
Jia-Yue
JY
Wang
Wei-Wei
WW
Zheng
Wei-Juan
WJ
D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism; D000596:Amino Acids / Q000235:genetics; D001482:Base Composition; D016009:Chi-Square Distribution; D003062:Codon; D019295:Computational Biology / Q000379:methods; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics* / Q000378:metabolism; D011506:Proteins / Q000737:chemistry / Q000235:genetics
D000596:Amino Acids; D003062:Codon; D011506:Proteins