title: The comparison of hair from gastric cancer patients and from healthy persons studied by infrared microspectroscopy and imaging using synchrotron radiation.
abstract: OBJECTIVE
  The objective is to apply synchrotron-based FTIR microspectroscopy and imaging to human hair tissue and investigate the possibility of the method in gastric cancer research and diagnosis.
  
  
  METHODS
  Human hair from gastric cancer patients' scalp and normal persons' scalp were studied by synchrotron-based FTIR microspectroscopy and imaging.
  
  
  RESULTS
  The micro-spectra and imaging show the difference between the normal and malignant hair tissues. Obvious peak shift of symmetric phosphate band is observed in micro-spectra of medulla region for the hair tissue of gastric cancer patients. Chemical imaging shows the distributions of lipid and amide II/v(s)PO(2)(-) have changed in the gastric cancer cases.
  
  
  CONCLUSIONS
  The study indicates that the hair tissue's infrared microspectroscopy and imaging using synchrotron will be a potentially useful method for rapid early gastric cancer diagnosis.
authors.affiliation: University of Science and Technology of China, Anhui 230029, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Wang
authors.forename: Zeming
authors.initials: Z
authors.lastname: Qi
authors.forename: Xingcun
authors.initials: X
authors.lastname: Liu
authors.forename: Shengyi
authors.initials: S
authors.lastname: Wang
authors.forename: Chengxiang
authors.initials: C
authors.lastname: Li
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.forename: Yin
authors.initials: Y
authors.lastname: Xiong
authors.forename: Tingting
authors.initials: T
authors.lastname: Li
authors.forename: Jinqiu
authors.initials: J
authors.lastname: Tao
authors.forename: Yangchao
authors.initials: Y
authors.lastname: Tian
mesh_terms: D000577:Amides / Q000032:analysis; D016022:Case-Control Studies; D003952:Diagnostic Imaging / Q000295:instrumentation*; D005260:Female; D006197:Hair / Q000737:chemistry*; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008297:Male; D011379:Prognosis; D012535:Scalp / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013274:Stomach Neoplasms / Q000175:diagnosis*; D017356:Synchrotrons
chemical_list: D000577:Amides; D008055:Lipids