Photochemical deuterium exchange in phenyl-substituted pyrroles and indoles in CD3CN-D2O.
A new mechanism of photochemical deuteration of some phenylpyrroles and indoles is reported. Irradiation of 2-phenylpyrrole (8), 2-phenylindole (9), and 7-phenylindole (12) in CH(3)CN-D(2)O gives rise to deuterium exchange at the C-atoms of the heterocycle and the adjacent phenyl ring. Photolysis of indole (7), 8, 9, 12 and N-methyl-2-phenylindole (10) in CD(3)CN-D(2)O also leads to deuteration at C-atoms with significantly higher yield. The mechanism most probably involves ejection of an electron on excitation and formation of radical cations that abstract D-atoms from CD(3)CN or undergo bimolecular D-abstraction (photolysis in CH(3)CN-D(2)O). The other possible mechanism of deuterium exchange for 7, 8, 9 and 12 may take place via a homolytic N-D cleavage and recombination of the radical pair. Radical cations of 8, 9 and 10 were detected by laser flash photolysis. Steady state and time-resolved fluorescence of 8, 9, 10 and 12 showed that photoinduced intramolecular electron transfer probably does not occur. The fluorescence was quenched by acid and base and the rate constants determined by Stern-Volmer analyses. The estimated pK(a) values for the protonation and deprotonation of the singlet excited states indicated that in neutral aqueous solutions ESPT probably does not take place, additionally corroborating the radical or radical cationic mechanism of deuteration.
Basarić
Nikola
N
Department of Organic Chemistry and Biochemistry, Ruder Bosković Institute, Bijenicka cesta 54, 10 000, Zagreb, Croatia. nbasaric@irb.hr
Franco-Cea
Alfredo
A
Alesković
Marija
M
Mlinarić-Majerski
Kata
K
Wan
Peter
P
D000097:Acetonitriles / Q000737:chemistry*; D003903:Deuterium / Q000737:chemistry*; D041961:Deuterium Exchange Measurement; D007211:Indoles / Q000737:chemistry*; D010084:Oxidation-Reduction; D010782:Photolysis; D011758:Pyrroles / Q000737:chemistry*; D011789:Quantum Theory; D014867:Water / Q000737:chemistry
D000097:Acetonitriles; D007211:Indoles; D011758:Pyrroles; D014867:Water; D003903:Deuterium