[Hyaluronan in inflammation, auto-immunity and cardio-vascular diseases].
Hyaluronan (H) is an ubiquitous high-molecular size glycosaminoglycan involved in many physiological functions. Evidences are numerous implying H in various pathological pathways, such as inflammation, cancer cardio-vascular diseases. CD44 is the principal membrane cell receptor of H. In inflammation, H has size-specific different biological activities. The high molecular weight H are anti-angiogenic, anti-inflammatory and immunosuppressive. Smaller H oligomers are angiogenic, inflammatory and immuno-stimulatory. H is strongly involved in the recruitment of leucocytes at the site of inflammation (role of CD44). Data giving evidence for a role of H in allergic pathways and auto-immunity are scarce. H is implicated in pathogenetic process leading to atherosclerosis.
Berbis
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Service de Dermatologie, Hôpital Nord, Chemin des Bourrellys, 13015 Marseille, France. philippe.berbis@ap-hm.fr
D000276:Adjuvants, Immunologic / Q000502:physiology*; D050197:Atherosclerosis / Q000209:etiology / Q000276:immunology*; D015551:Autoimmunity; D002318:Cardiovascular Diseases / Q000276:immunology; D006801:Humans; D006820:Hyaluronic Acid / Q000276:immunology* / Q000502:physiology; D007165:Immunosuppression Therapy; D007249:Inflammation / Q000276:immunology*; D008970:Molecular Weight
D000276:Adjuvants, Immunologic; D006820:Hyaluronic Acid