Disease association of the CD103 polymorphisms in Taiwan Chinese Graves' ophthalmopathy patients.
OBJECTIVE
To evaluate whether variations in the CD103 gene could be associated with Graves' ophthalmopathy (GO) in patients with Graves' disease.


METHODS
Case-control study.


METHODS
A total of 484 Chinese patients with Graves' disease in Taiwan, including 203 patients with GO and 281 patients without GO, were enrolled.


METHODS
Five single nucleotide polymorphisms (SNPs) in CD103 were genotyped using an assay-on-demand allelic discrimination assay and detection system according to the manufacturer's instructions.


METHODS
Association of SNPs in CD103 with the development of GO.


RESULTS
The CD103 SNP rs11652878 was associated with GO, which may decrease the risk of GO by 1.57-fold (P = 0.029). The Ht5-GCGCG haplotype, composed of 5 SNPs in the CD103 gene (rs1716, rs3744679, rs11652878, rs16953477, and rs9905739), were protective haplotypes (P = 0.010). Moreover, the heterozygous genotype (Ht5/non-Ht5) was correlated with a reduced risk of GO and high grades of goiter as compared with the non-Ht5/non-Ht5 genotype (P = 0.006 and P = 0.048, respectively). Logistic analysis confirmed the contribution of CD103 rs11652878 to the protection of GO.


CONCLUSIONS
These data suggest that patients with Graves' disease in the presence of the G allele of SNP rs11652878, especially Ht5-GCGCG, in CD103 are less susceptible toward the development of GO.
Liu
Yu-Huei
YH
Genetic Center, China Medical University Hospital, Taichung, Taiwan.
Chen
Rong-Hsing
RH
Chen
Wen-Chi
WC
Tsai
Yuhsin
Y
Wan
Lei
L
Tsai
Fuu-Jen
FJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D049970:Graves Ophthalmopathy / Q000235:genetics*; D006801:Humans; D039001:Integrin alpha Chains / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D013624:Taiwan / Q000453:epidemiology; D055815:Young Adult
D015703:Antigens, CD; D039001:Integrin alpha Chains; C091367:alpha E integrins