title: Stereotactic body radiotherapy for lung tumors at the pulmonary hilum.
abstract: OBJECTIVE
  High-dose irradiation to the pulmonary hilar region is generally considered to be of high risk in causing bronchial injury. The aim of this retrospective study is to investigate the safety and efficacy of stereotactic body radiotherapy (SBRT) for patients with lung tumors in the pulmonary hilum.
  
  
  METHODS
  21 patients who underwent SBRT for lung tumors within 2 cm from a major bronchus were retrospectively analyzed. The total biologically effective doses ranging from 50.7 to 157.5 Gy (median, 100 Gy) were given to the tumors by SBRT.
  
  
  RESULTS
  The overall survival rates at 1 and 2 years after SBRT were 90.0% and 62.2%, respectively. Nine patients were alive and 15 irradiated tumors were controlled during the follow-up period of 10-54 months (median, 20 months). Nine patients died of tumor progression and one patient each died of hemoptysis, infectious pneumonia, and epidural hemorrhage. Severe late toxicity (>or= grade 3) was seen in three patients of whom two had previously received repeated radiotherapy.
  
  
  CONCLUSIONS
  SBRT for lung tumors located in the pulmonary hilar region may be tolerable and acceptable, if multiple treatments to the same major bronchus are avoided, and irradiated volumes are carefully taken into consideration.
authors.affiliation: Department of Radiation Oncology, University of Tsukuba, Tsukuba, Ibaraki, Japan. ooyoshiko@pmrc.tsukuba.ac.jp
authors.forename: Yoshiko
authors.initials: Y
authors.lastname: Oshiro
authors.forename: Takashi
authors.initials: T
authors.lastname: Aruga
authors.forename: Koji
authors.initials: K
authors.lastname: Tsuboi
authors.forename: Kan
authors.initials: K
authors.lastname: Marino
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Hara
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Sanayama
authors.forename: Jun
authors.initials: J
authors.lastname: Itami
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008168:Lung / Q000473:pathology / Q000601:surgery; D008175:Lung Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D016634:Radiosurgery / Q000009:adverse effects / Q000379:methods*; D017741:Survivors