[Bronchiolitis with IgG4-positive plasma cell infiltration in a patient with bronchial asthma].
A 49-year-old-man was admitted to our hospital because of cough, wheezing, and dyspnea. Chest CT showed bilateral bronchocentric nodules and increased bronchial thickness. And he was given a diagnosis of bronchial asthma. However, another small airway disease, such as diffuse panbronchiolitis (DPB) was also suspected, and surgical lung biopsy was performed. The biopsy specimens showed a prominent peribronchial lymphoplasmacytic and eosinophilic infiltration with IgG4-positive plasma cells. IgG4-positive plasma cells may play a role in the pathogenesis of bronchiolar diseases associated with allergic airway inflammation.
Hasegawa
Hirotsugu
H
Department of Respiratory Medicine, Hamamatsu University School of Medicine.
Nakamura
Yutaro
Y
Kono
Masato
M
Akamatsu
Taisuke
T
Kaida
Yusuke
Y
Inui
Naoki
N
Suda
Takafumi
T
Chida
Kingo
K
D001249:Asthma / Q000150:complications*; D001988:Bronchiolitis / Q000150:complications / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008875:Middle Aged; D010950:Plasma Cells / Q000276:immunology / Q000473:pathology*
D007074:Immunoglobulin G