title: Synthesis of acyclic nucleosides with a chiral amino side chain by the Mitsunobu coupling reaction.
abstract: A novel and efficient synthetic method has been developed for the preparation of chiral acyclic nucleosides with a chiral amino side chain by Mitsunobu reaction between nucleoside bases and protected L-serine. This method suggests a potentially more efficient and complementary process to acquire chiral acyclic nucleosides.
authors.affiliation: College of Chemistry and Environmental Science, Key Laboratory of Green Chemical Media and Reactions of Ministry of Education, Henan Normal University, Xinxiang 453007, Henan, China. ghm@htu.cn
authors.forename: Hai-Ming
authors.initials: HM
authors.lastname: Guo
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Wu
authors.forename: Hong-Ying
authors.initials: HY
authors.lastname: Niu
authors.forename: Dong-Chao
authors.initials: DC
authors.lastname: Wang
authors.forename: Gui-Rong
authors.initials: GR
authors.lastname: Qu
mesh_terms: D000588:Amines; D008722:Methods; D009705:Nucleosides / Q000138:chemical synthesis*; D055601:Organic Chemistry Phenomena; D012694:Serine
chemical_list: D000588:Amines; D009705:Nucleosides; D012694:Serine