[Effects of chronic fluoxetine treatment on manifestation of sexual motivation and social behavior in mice of ASC line].
Sexual dysfunctions are the typical symptoms accompanying depressive disorders. However antidepressants which improve general state of the patients have no effect on sexual disorders. Mice of ASC (Antidepressant Sensitive Catalepsy) line with high hereditary predisposition to catalepsy were proposed as a model of genetically associated depressive-like condition. The work was aimed at comparison of behavioral indices of sexual motivation and social interest of ASC mice with those of mice of parental inbred AKR and CBA strains, and at the study of the effects of chronic fluoxetine treatment in doses of 10 and 20 mg/kg on these parameters in ASC mice. ASC males demonstrated reduced sexual motivation which was not corrected by fluoxetine. ASC mice did not differ in the expression of social interest and aggression towards juvenile intruder from mice of parental strains. Fluoxetine failed to alter social behavior of ASC mice in social interaction test but its higher dose decreased percentage of aggressors. ASC mouse line seems to be a perspective model to study genetic mechanisms of sexual dysfunctions associated with depressive conditions.
Tikhonova
M A
MA
Otroshchenko
E A
EA
Kulikov
A V
AV
D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008808:Mice, Inbred CBA; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D012919:Social Behavior; D013045:Species Specificity
D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine