title: A new 3-D automated computational method to evaluate in-stent neointimal hyperplasia in in-vivo intravascular optical coherence tomography pullbacks.
abstract: Detection of stent struts imaged in vivo by optical coherence tomography (OCT) after percutaneous coronary interventions (PCI) and quantification of in-stent neointimal hyperplasia (NIH) are important. In this paper, we present a new computational method to facilitate the physician in this endeavor to assess and compare new (drug-eluting) stents. We developed a new algorithm for stent strut detection and utilized splines to reconstruct the lumen and stent boundaries which provide automatic measurements of NIH thickness, lumen and stent area. Our original approach is based on the detection of stent struts unique characteristics: bright reflection and shadow behind. Furthermore, we present for the first time to our knowledge a rotation correction method applied across OCT cross-section images for 3D reconstruction and visualization of reconstructed lumen and stent boundaries for further analysis in the longitudinal dimension of the coronary artery. Our experiments over OCT cross-sections taken from 7 patients presenting varying degrees of NIH after PCI illustrate a good agreement between the computer method and expert evaluations: Bland-Altmann analysis revealed a mean difference for lumen cross-section area of 0.11 +/- 0.70 mm2 and for the stent cross-section area of 0.10 +/- 1.28 mm2.
authors.affiliation: Faculty of Engineering and Natural Sciences, Sabanci, University, Istanbul, Turkey
authors.forename: Serhan
authors.initials: S
authors.lastname: Gurmeric
authors.forename: Gozde Gul
authors.initials: GG
authors.lastname: Isguder
authors.forename: Stfphane
authors.initials: S
authors.lastname: Carlier
authors.forename: Gozde
authors.initials: G
authors.lastname: Unal
mesh_terms: D000465:Algorithms; D001185:Artificial Intelligence; D023903:Coronary Restenosis / Q000209:etiology* / Q000473:pathology*; D020878:Device Removal / Q000379:methods; D006083:Graft Occlusion, Vascular / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015607:Stents / Q000009:adverse effects*; D041623:Tomography, Optical Coherence / Q000379:methods*