title: Adult height in children with growth hormone deficiency: a randomized, controlled, growth hormone dose-response trial.
abstract: OBJECTIVE
  To investigate the effect of 2 growth hormone (GH) doses on adult height (AH) in GH deficiency (GHD).
  
  
  METHODS
  A multicenter, randomized, controlled dose-response trial compared attained AH minus target height (TH) between children receiving 0.7 mg/m(2)/day biosynthetic GH (approx. 0.025 mg/kg/day) or 1.4 mg/m(2)/day (approx. 0.050 mg/kg/day). The patients enrolled in the trial were 20 'naïve' GHD children (had not received GH before) and 15 'transfer' GHD children (already on GH for at least 1 year).
  
  
  RESULTS
  In the naïve group, the mean +/- SD AH minus TH was -5.3 +/- 6.1 and -2.2 +/- 6.9 cm in patients on 0.7 and 1.4 mg/m(2)/day, respectively (mean +/- SE difference 3.1 +/- 2.9; p = 0.3). In the transfer group, the mean +/- SD AH minus TH was -4.4 +/- 6.4 and +0.6 +/- 7.0 cm in patients on 0.7 and 1.4 mg/m(2)/day, respectively (mean +/- SE difference 5.0 +/- 3.5; p = 0.17). Spontaneous puberty started 1.1 years earlier in children on 1.4 compared to 0.7 mg/m(2)/day. Induction of puberty was more often delayed in transfer children on 0.7 than on 1.4 mg/m(2)/day.
  
  
  CONCLUSIONS
  In our GHD patients, AH was 4-5 cm less than TH in patients on 0.7 mg/m(2)/day GH, while it was 0-2 cm less in patients on 1.4 mg/m(2)/day GH, but this difference did not reach statistical significance, probably due to limited numbers of patients, considerable variability in the growth response and earlier spontaneous puberty and pubertal induction in the children on 1.4 mg/m(2)/day.
authors.affiliation: Department of Pediatrics, Erasmus MC-Sophia Children's Hospital Rotterdam, The Netherlands. t.sas@erasmusmc.nl
authors.forename: Theo C J
authors.initials: TC
authors.lastname: Sas
authors.forename: Maria A J
authors.initials: MA
authors.lastname: de Ridder
authors.forename: Jan M
authors.initials: JM
authors.lastname: Wit
authors.forename: Joost
authors.initials: J
authors.lastname: Rotteveel
authors.forename: Wilma
authors.initials: W
authors.lastname: Oostdijk
authors.forename: H Maarten
authors.initials: HM
authors.lastname: Reeser
authors.forename: Barto J
authors.initials: BJ
authors.lastname: Otten
authors.forename: Sabine M P F
authors.initials: SM
authors.lastname: de Muinck Keizer-Schrama
mesh_terms: D000293:Adolescent; D001827:Body Height / Q000187:drug effects*; D002648:Child; D004305:Dose-Response Relationship, Drug; D004393:Dwarfism, Pituitary / Q000188:drug therapy*; D005260:Female; D013006:Growth Hormone / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D016896:Treatment Outcome
chemical_list: D013006:Growth Hormone