[Preparation of water-soluble chitosan solid dispersion of daidzein].
OBJECTIVE
To enhance the dissolution rate of daidzein with solid dispersion technique.


METHODS
Solid dispersions were prepared by the solvent method using water-solubility chitosan as a hydrophilic carrier. DSC, IR and X-ray methods were used to verify the formation of solid dispersion.


RESULTS
Dissolution percentages of solid dispersions were more than 90 percent in the drug-carrier ratio of 1:5 and 1:9. But dissolution percentages of physical mixtures and pure drug were 40 and 38.4 percent respectively. Part of daidzein dispersed in solid dispersion in the form of microcrystalline.


CONCLUSIONS
Water-soluble chitosan solid dispersion can significantly increase dissolution rate of daidzein.
Ge
Yuebin
Y
School of Pharmacy, South-central University For Nationalities, Wuhan 430074, China. geyuebin@mail.scuec.edu.cn
Wang
Xubin
X
Guo
Weilin
W
Xie
Xiaomin
X
D002152:Calorimetry, Differential Scanning; D048271:Chitosan / Q000737:chemistry*; D007529:Isoflavones / Q000737:chemistry*; D012995:Solubility; D013055:Spectrophotometry, Infrared; D014867:Water / Q000737:chemistry*; D014961:X-Ray Diffraction
D007529:Isoflavones; D014867:Water; C004742:daidzein; D048271:Chitosan