Essential fatty acid deficiency reduces cortical spreading depression propagation in rats: a two-generation study.
Cortical spreading depression (CSD) propagation was investigated in rats under dietary essential fatty acid (EFA) deficiency over two generations (F1 and F2). Wistar rat dams received diets containing 5% fat either from coconut-oil (EFA-deficient) or soybean-oil (control). F1-pups received their dams' diets until the day of CSD recording (30-40 days or 90-100 days). F2-pups were kept on their F1 dams' diet until 30-40 days. Compared to the controls, the EFA-deficient group had reduced (P < 0.05) body weights in both F1 and F2 conditions. This effect was more conspicuous (P < 0.001) in the F2-animals where brain weight was also reduced (P < 0.05). All EFA-deficient groups displayed lower CSD velocities (P < 0.001) than the corresponding controls. Within the same dietary group and generation, F1 young rats showed higher CSD velocities (P < 0.001) than adults. Data show that EFA deficiency reduces CSD propagation, and this effect is long lasting as it persists up to the second generation.
Borba
Juliana Maria Carrazzone
JM
Laboratório de Fisiologia da Nutrição Naíde Teodósio, Departamento de Nutrição, Universidade Federal de Pernambuco, Recife, PE 50670-901, Brazil. jucarrazzone@gmail.com
Rocha-de-Melo
Ana Paula
AP
dos Santos
Angela Amâncio
AA
da Costa
Belmira Lara da Silveira Andrade
BL
da Silva
Reginaldo Pereira
RP
Passos
Priscila Pereira
PP
Guedes
Rubem Carlos Araújo
RC
D000375:Aging; D000818:Animals; D001835:Body Weight; D001921:Brain / Q000473:pathology; D013181:Cortical Spreading Depression / Q000502:physiology*; D004569:Electroencephalography; D005228:Fatty Acids, Essential / Q000172:deficiency*; D005260:Female; D008297:Male; D039382:Maternal Nutritional Physiological Phenomena; D009929:Organ Size; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar
D005228:Fatty Acids, Essential