Ceramide-mediated transport of chloride and bicarbonate across phospholipid membranes.
The sphingolipid, ceramide 1, facilitates transport of Cl(-) and HCO(3)(-) anions across lipid bilayers under conditions where large transmembrane pores are not formed. Ceramide's 1,3-diol unit is essential for both binding and transporting these anions.
Harrell
William A
WA
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20740, USA.
Bergmeyer
Marie Liesel
ML
Zavalij
Peter Y
PY
Davis
Jeffery T
JT
D001639:Bicarbonates / Q000378:metabolism*; D001692:Biological Transport; D002518:Ceramides / Q000737:chemistry* / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism*; D008051:Lipid Bilayers / Q000737:chemistry*
D001639:Bicarbonates; D002518:Ceramides; D002712:Chlorides; D008051:Lipid Bilayers