title: Epidemiologic trends in lung cancer over two decades in Northern Greece: an analysis of bronchoscopic data.
abstract: OBJECTIVE
  The relative frequency of histological subtypes of lung cancer in Europe has changed dramatically during the 20th century. The aim of this study was to explore the changing epidemiology of lung cancer in Northern Greece over the last two decades.
  
  
  METHODS
  From the extensive database of the Bronchoscopy Unit of the G. Papanicolaou General Hospital, Thessaloniki, Greece, we identified all patients with a histologic and/or cytologic report positive for lung cancer over two consecutive decades.
  
  
  RESULTS
  Between 1/1/1986 and 31/12/2005 we identified 9981 patients with specimens positive for lung cancer. A significant increase in mean patient age was observed during the second decade (64.8 +/- 9.4 vs. 62.1 +/- 8.9, p=0.001). Men developed lung cancer ten times more often than women. The predominant histological type was squamous cell cancer in males (4203 cases, 45.7%) and adenocarcinoma (418 cases, 52.6%) in females. The number of lung cancer cases was significantly higher during the second decade compared to the first decade (5766 cases [57.8%] vs. 4215 cases [42.2%], respectively, p<0.001). There was a significant decrease in the percentage of squamous cell carcinoma in males in the second decade (2317 cases [44.1%] vs. 1886 cases [48.0%], p<0.001), and an increase in adenocarcinoma (1021 cases [19.4%] vs. 609 [11.6%], p<0.001). In females, the relative incidence of adenocarcinoma was decreased and that of squamous cell carcinoma was increased, but not significantly. There was no obvious change in the incidence of small cell lung cancer. Neoplastic lesions were most often located in the upper lobes.
  
  
  CONCLUSIONS
  The number of lung cancer cases has increased in the last decade. Squamous lung cancer appears to be decreasing in men and increasing in women. Adenocarcinoma appears to be increasing in men and decreasing in women. There appears to be no change in small cell lung cancer. During the second decade there has been a significant decrease in the male: female ratio.
authors.affiliation: Bronchoscopy Unit, Dept. of Pneumonology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. kontak@auth.gr
authors.forename: T
authors.initials: T
authors.lastname: Kontakiotis
authors.forename: N
authors.initials: N
authors.lastname: Manolakoglou
authors.forename: F
authors.initials: F
authors.lastname: Zoglopitis
authors.forename: D
authors.initials: D
authors.lastname: Iakovidis
authors.forename: L
authors.initials: L
authors.lastname: Sacas
authors.forename: A
authors.initials: A
authors.lastname: Papagiannis
authors.forename: A
authors.initials: A
authors.lastname: Mandrali
authors.forename: D
authors.initials: D
authors.lastname: Papakosta
authors.forename: P
authors.initials: P
authors.lastname: Argyropoulou
authors.forename: D
authors.initials: D
authors.lastname: Bouros
mesh_terms: D018195:Adenosarcoma / Q000453:epidemiology*; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001999:Bronchoscopy; D016208:Databases, Factual; D005260:Female; D006115:Greece / Q000453:epidemiology; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018307:Neoplasms, Squamous Cell / Q000453:epidemiology*; D015995:Prevalence; D017678:Sex Distribution; D055752:Small Cell Lung Carcinoma / Q000453:epidemiology*