title: A vHTS approach for the identification of beta-adrenoceptor ligands.
abstract: Using a vHTS based on a pharmacophore alignment on known beta3-adrenoceptor ligands, a set of intriguing beta-adrenoceptor ligands was identified, optimization of which resulted in a selective and potent human beta2-AR antagonist.
authors.affiliation: 4SC AG, Am Klopferspitz 19a, 82152 Planegg-Martinsried, Germany. stefan.tasler@4sc.com
authors.forename: Stefan
authors.initials: S
authors.lastname: Tasler
authors.forename: Roland
authors.initials: R
authors.lastname: Baumgartner
authors.forename: Andrea
authors.initials: A
authors.lastname: Aschenbrenner
authors.forename: Astrid
authors.initials: A
authors.lastname: Ammendola
authors.forename: Kristina
authors.initials: K
authors.lastname: Wolf
authors.forename: Tanja
authors.initials: T
authors.lastname: Wieber
authors.forename: Josef
authors.initials: J
authors.lastname: Schachtner
authors.forename: Marcus
authors.initials: M
authors.lastname: Blisse
authors.forename: Udo
authors.initials: U
authors.lastname: Quotschalla
authors.forename: Peter
authors.initials: P
authors.lastname: Ney
mesh_terms: D006207:Half-Life; D006801:Humans; D006860:Hydrogen Bonding; D008024:Ligands; D008958:Models, Molecular; D011943:Receptors, Adrenergic, beta / Q000378:metabolism*
chemical_list: D008024:Ligands; D011943:Receptors, Adrenergic, beta