title: T1rho MRI quantification of arthroscopically confirmed cartilage degeneration.
abstract: Nine asymptomatic subjects and six patients underwent T(1)rho MRI to determine whether Outerbridge grade 1 or 2 cartilage degeneration observed during arthroscopy could be detected noninvasively. MRI was performed 2-3 months postarthroscopy, using sagittal T(1)-weighted and axial and coronal T(1)rho MRI, from which spatial T(1)rho relaxation maps were calculated from segmented T(1)-weighted images. Median T(1)rho relaxation times of patients with arthroscopically documented cartilage degeneration and asymptomatic subjects were significantly different (P < 0.001), and median T(1)rho exceeded asymptomatic articular cartilage median T(1)rho by 2.5 to 9.2 ms. In eight observations of mild cartilage degeneration at arthroscopy (Outerbridge grades 1 and 2), mean compartment T(1)rho was elevated in five, but in all observations, large foci of increased T(1)rho were observed. It was determined that T(1)rho could detect some, but not all, Outerbridge grade 1 and 2 cartilage degeneration but that a larger patient population is needed to determine the sensitivity to these changes.
authors.affiliation: Biochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. witschey@med.upenn.edu
authors.forename: Walter R T
authors.initials: WR
authors.lastname: Witschey
authors.forename: Arijitt
authors.initials: A
authors.lastname: Borthakur
authors.forename: Matt
authors.initials: M
authors.lastname: Fenty
authors.forename: Bruce J
authors.initials: BJ
authors.lastname: Kneeland
authors.forename: Jess H
authors.initials: JH
authors.lastname: Lonner
authors.forename: Erin L
authors.initials: EL
authors.lastname: McArdle
authors.forename: Matt
authors.initials: M
authors.lastname: Sochor
authors.forename: Ravinder
authors.initials: R
authors.lastname: Reddy
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001182:Arthroscopy; D002356:Cartilage / Q000473:pathology*; D002357:Cartilage Diseases / Q000473:pathology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity