title: Accelerating feature based registration using the Johnson-Lindenstrauss Lemma.
abstract: We introduce an efficient search strategy to substantially accelerate feature based registration. Previous feature based registration algorithms often use truncated search strategies in order to achieve small computation times. Our new accelerated search strategy is based on the realization that the search for corresponding features can be dramatically accelerated by utilizing Johnson-Lindenstrauss dimension reduction. Order of magnitude calculations for the search strategy we propose here indicate that the algorithm proposed is more than a million times faster than previously utilized naive search strategies, and this advantage in speed is directly translated into an advantage in accuracy as the fast speed enables more comparisons to be made in the same amount of time. We describe the accelerated scheme together with a full complexity analysis. The registration algorithm was applied to large transmission electron microscopy (TEM) images of neural ultrastructure. Our experiments demonstrate that our algorithm enables alignment of TEM images with increased accuracy and efficiency compared to previous algorithms.
authors.affiliation: Computational Radiology Laboratory, Children's Hospital, Harvard Medical School, Boston, USA.
authors.forename: Ayelet
authors.initials: A
authors.lastname: Akselrod-Ballin
authors.forename: Davi
authors.initials: D
authors.lastname: Bock
authors.forename: R Clay
authors.initials: RC
authors.lastname: Reid
authors.forename: Simon K
authors.initials: SK
authors.lastname: Warfield
mesh_terms: D000465:Algorithms; D000818:Animals; D001185:Artificial Intelligence; D005289:Ferrets; D005829:Geniculate Bodies / Q000648:ultrastructure*; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008854:Microscopy, Electron / Q000379:methods*; D010363:Pattern Recognition, Automated / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013382:Subtraction Technique