Identification of TEM-135 beta-lactamase in penicillinase-producing Neisseria gonorrhoeae strains in Japan.
Ten penicillinase-producing Neisseria gonorrhoeae (PPNG) strains isolated from 2000 to 2008 were characterized by multilocus sequence typing, multiantigen sequence typing, and plasmid typing. Sequence analysis showed that 8 strains contained a TEM-1 beta-lactamase gene. However, two other genetically distinct PPNG strains, isolated in 2004 and 2008, each contained a TEM-135 beta-lactamase on different plasmids, a Toronto/Rio type R plasmid and an Asia type R plasmid, suggesting independent origins of these PPNG strains.
Ohnishi
Makoto
M
Department of Bacteriology I, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku, Tokyo 162-8640, Japan. ohnishi7@nih.go.jp
Ono
Emi
E
Shimuta
Ken
K
Watanabe
Haruo
H
Okamura
Noboru
N
D007564:Japan; D008969:Molecular Sequence Data; D009344:Neisseria gonorrhoeae / Q000201:enzymology* / Q000235:genetics; D010405:Penicillinase / Q000235:genetics*; D010957:Plasmids / Q000235:genetics; D001618:beta-Lactamases / Q000235:genetics*
D010405:Penicillinase; D001618:beta-Lactamases