title: Gel-sol-gel thermo-gelation behavior study of chitosan-inorganic phosphate solutions.
abstract: In present study, the feasibility of developing a novel thermo-sensitive hydrogel suitable for injectable formulations based on chitosan and inorganic phosphate was demonstrated. The physicochemical and rheological changes of chitosan/dibasic sodium phosphate solutions as in function with temperature were investigated in order to gain a better understanding of gelation process. According to the result of rheological study, there are two phase transition points as in function with temperature, corresponding to 30 degrees C and 43 degrees C. The system is gel state at approximately 4 degrees C. With the temperature increased to 30 degrees C, the gel-sol transition as well as the decrease in turbidity was observed. The sol-gel transition as well as the increase in turbidity was observed again as the temperature was above 43 degrees C. And the gel obtained at approximately 4 degrees C is reversible, but the gel obtained at approximately 43 degrees C is irreversible.
authors.affiliation: State Key Laboratory of Biotherapy and Cancer Center, Sichuan University, Chengdu, China.
authors.forename: XingYi
authors.initials: X
authors.lastname: Li
authors.forename: XiangYe
authors.initials: X
authors.lastname: Kong
authors.forename: XiuHong
authors.initials: X
authors.lastname: Wang
authors.forename: Shuai
authors.initials: S
authors.lastname: Shi
authors.forename: Gang
authors.initials: G
authors.lastname: Guo
authors.forename: Feng
authors.initials: F
authors.lastname: Luo
authors.forename: Xia
authors.initials: X
authors.lastname: Zhao
authors.forename: YuQuan
authors.initials: Y
authors.lastname: Wei
authors.forename: ZhiYong
authors.initials: Z
authors.lastname: Qian
mesh_terms: D048271:Chitosan / Q000737:chemistry*; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D009391:Nephelometry and Turbidimetry; D009994:Osmolar Concentration; D010710:Phosphates / Q000737:chemistry*; D012212:Rheology; D012996:Solutions; D013696:Temperature
chemical_list: D020100:Hydrogels; D010710:Phosphates; D012996:Solutions; D048271:Chitosan