Randomized, comparative pilot study of pituitary suppression with depot leuprorelin versus cetrorelix acetate 3 mg in gonadotropin stimulation protocols for oocyte donors.
In a pilot study, implantation and pregnancy rates per transfer were favorable in recipients of donated eggs treated with a single dose of cetrorelix acetate 3 mg compared with recipients of donated eggs treated with the long protocol (42.3% vs. 30.5%, and 71.0% vs. 46.7%, respectively; NS). The stimulation protocol based on gonadotropins and a single dose of cetrorelix acetate 3 mg is adequate in terms of safety and comfort of donors and the likelihood of pregnancy among recipients, although these favorable results require confirmation in future studies.
Martínez
Fracisca
F
Salud de la Mujer Dexeus, Obstetrics, Gynaecology, and Reproduction Department, Institut Universitari Dexeus, Barcelona, Spain. pacmar@dexeus.com
Clua
Elisabeth
E
Santmartí
Paula
P
Boada
Montserrat
M
Rodriguez
Ignacio
I
Coroleu
Buenaventura
B
D000328:Adult; D003692:Delayed-Action Preparations; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000009:adverse effects; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D006062:Gonadotropins / Q000008:administration & dosage* / Q000009:adverse effects; D006727:Hormone Antagonists / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage* / Q000009:adverse effects; D018587:Oocyte Donation / Q000009:adverse effects / Q000379:methods*; D010062:Ovulation Induction / Q000379:methods*; D010865:Pilot Projects; D010902:Pituitary Gland / Q000187:drug effects; D010907:Pituitary Hormones / Q000037:antagonists & inhibitors*; D011247:Pregnancy; D018873:Pregnancy Rate; D014019:Tissue Donors; D055815:Young Adult
D003692:Delayed-Action Preparations; D005300:Fertility Agents, Female; D006062:Gonadotropins; D006727:Hormone Antagonists; D010907:Pituitary Hormones; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide; C062876:cetrorelix