Malignant rhabdoid tumor of the kidney combined with multicystic dysplasia in a 5-year-old child.
Multicystic dysplastic kidney (MCDK) is a relatively common developmental anomaly in infants and children and has a good prognosis. In contrast, a malignant rhabdoid tumor of the kidney (MRTK) is one of the most lethal neoplasms of early life. However, the presentation of such a lethal tumor combined with multicystic dysplasia has not been reported to date. In this report, we describe a case of MRTK in a 5-yr-old girl who also had multicystic dysplasia. She was previously diagnosed with MCDK at birth due to a huge palpable mass on the right side of the abdomen. The right kidney was extensively replaced by numerous grossly dilated, variable-sized cysts. Microscopically, the tumor cells show a diffusely infiltrative growth pattern, which revealed large non-cohesive, round-to-polygonal tumor cells with vesicular nuclei. Some tumor cells had eccentric nuclei and large, round, eosinophilic cytoplasmic inclusions. There were metanephrons present, with the central ureteric bud and peripheral branches surrounded by condensing mesenchyma, immature glomeruli, and metaplastic cartilage in the adjacent parenchyma. To our knowledge, this is the first combined case of the two aforementioned diseases and this case may, in fact, suggest a new disease entity.
Cui
Ying
Y
Department of Pathology, Yonsei University Wonju College of Medicine, Wonju, Korea.
Eom
Minseob
M
Jung
Soon-Hee
SH
Kim
Kwang Jin
KJ
Jung
Woo Hee
WH
D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications* / Q000175:diagnosis*; D021782:Multicystic Dysplastic Kidney / Q000150:complications* / Q000175:diagnosis*; D011379:Prognosis; D018335:Rhabdoid Tumor / Q000150:complications* / Q000175:diagnosis*