Fast onset of action and the analgesic and sedative efficacy of essential oil from Rhizoma Chuanxiong after nasal administration.
In this study, the analgesic and sedative efficacy of Chuanxiong essential oil after nasal administration was compared with that of the commonly used oral administration route. The essential oil significantly reduced nociception only 5 min after nasal administration but not by i.g. administration. The essential oil significantly decreased the sleep latency and prolonged the sleeping time only 5 min after i.n. administration but not by the i.g. route. Taken together, these data demonstrate that the essential oil from Rhizoma Chuanxiong had faster onset of action as well as better analgesic and sedative efficacy after i.n. administration than given orally.
Guo
Jianming
J
Jiangsu Key Laboratory for TCM formulae Research, Nanjing University of Chinese Medicine, Nanjing, P.R. China.
Duan
Jin-ao
JA
Tang
Yuping
Y
Jia
Ning
N
Li
Xinghu
X
Zhang
Ji
J
D019342:Acetic Acid; D000281:Administration, Intranasal; D018712:Analgesics, Non-Narcotic; D000818:Animals; D004357:Drug Synergism; D005260:Female; D006358:Hot Temperature; D006993:Hypnotics and Sedatives; D007202:Indicators and Reagents; D030004:Ligusticum / Q000737:chemistry*; D051379:Mice; D008813:Mice, Inbred ICR; D009822:Oils, Volatile / Q000008:administration & dosage / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011930:Reaction Time / Q000187:drug effects; D012890:Sleep / Q000187:drug effects
D018712:Analgesics, Non-Narcotic; D006993:Hypnotics and Sedatives; D007202:Indicators and Reagents; D009822:Oils, Volatile; D010936:Plant Extracts; D010424:Pentobarbital; D019342:Acetic Acid