Family-based association study for bipolar affective disorder.
In this study we aimed to evaluate 21 candidate loci for bipolar affective disorder (BPAD) identified earlier in a large genome-wide association study. We evaluated 74 pedigrees with BPAD, with a total of 411 individuals, including 96 patients who fulfilled clinical criteria for BPAD according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition classification. Family-based association analysis was performed using the UNPHASED software. We identified a single nucleotide polymorphism (rs9834970) localized on chromosome 3p22.3, showing statistically significant association with BPAD after the Bonferroni correction for multiple comparisons (P(corrected)=0.0025) with an odds ratio=2.64 (95% confidence interval: 1.30-5.35). Single nucleotide polymorphism rs9834970 is located in an intergenic region and is not known to be associated to regulatory genomic sequences.
Secolin
Rodrigo
R
Department of Medical Genetics, University of Campinas-UNICAMP, Campinas, Sao Paulo, Brazil.
Banzato
Cláudio E M
CE
Oliveira
Maria C M
MC
Bittar
Maria F R
MF
Santos
Marilza L
ML
Dalgalarrondo
Paulo
P
Lopes-Cendes
Iscia
I
D001714:Bipolar Disorder / Q000235:genetics*; D005190:Family; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics