Marfan syndrome in a Triple-X girl: a new association?
BACKGROUND
Triple X is a sex chromosomal abnormality that involves the presence of three sex chromosomes resulting in 47, XXX karyotype. Most patients suffering from this syndrome are usually mentally normal or subnormal with no gross malformation.


OBJECTIVE
to report an unusual association between Triple X and Marfan disease in a girl.


METHODS
A case of a triple X girl with craniofacial dysmorphy and skeletal anomalies, who did feat Marfan criteria by age, is presented.


CONCLUSIONS
To the best of our knowledge this association has never been reported. Some clinical features are common between Triple X and Marfan disease so a careful follow-up is needed and investigations should be performed in these patients because Marfan syndrome may be incomplete in early age.
Tinsa
Faten
F
Department of Pediatrics B, Children's Hospital of Tunis.
Karboul
Lotfi
L
Chekib
Jalel
J
Hamouda
Samia
S
Ben Jemaa
Lamia
L
Boussetta
Khadija
K
Bousnina
Souad
S
D000015:Abnormalities, Multiple; D001284:Atrophy / Q000000981:diagnostic imaging; D001921:Brain / Q000473:pathology; D041321:Chromosomes, Human, X / Q000235:genetics*; D003241:Consanguinity; D005260:Female; D006801:Humans; D007223:Infant; D008382:Marfan Syndrome / Q000235:genetics*; D011859:Radiography; D012729:Sex Chromosome Aberrations