title: The DRAGO gamma camera.
abstract: In this work, we present the results of the experimental characterization of the DRAGO (DRift detector Array-based Gamma camera for Oncology), a detection system developed for high-spatial resolution gamma-ray imaging. This camera is based on a monolithic array of 77 silicon drift detectors (SDDs), with a total active area of 6.7 cm(2), coupled to a single 5-mm-thick CsI(Tl) scintillator crystal. The use of an array of SDDs provides a high quantum efficiency for the detection of the scintillation light together with a very low electronics noise. A very compact detection module based on the use of integrated readout circuits was developed. The performances achieved in gamma-ray imaging using this camera are reported here. When imaging a 0.2 mm collimated (57)Co source (122 keV) over different points of the active area, a spatial resolution ranging from 0.25 to 0.5 mm was measured. The depth-of-interaction capability of the detector, thanks to the use of a Maximum Likelihood reconstruction algorithm, was also investigated by imaging a collimated beam tilted to an angle of 45 degrees with respect to the scintillator surface. Finally, the imager was characterized with in vivo measurements on mice, in a real preclinical environment.
authors.affiliation: Dipartimento di Elettronica e Informazione, Politecnico di Milano, Milano 20133, Italy. carlo.fiorini@polimi.it
authors.forename: C
authors.initials: C
authors.lastname: Fiorini
authors.forename: A
authors.initials: A
authors.lastname: Gola
authors.forename: R
authors.initials: R
authors.lastname: Peloso
authors.forename: A
authors.initials: A
authors.lastname: Longoni
authors.forename: P
authors.initials: P
authors.lastname: Lechner
authors.forename: H
authors.initials: H
authors.lastname: Soltau
authors.forename: L
authors.initials: L
authors.lastname: Strüder
authors.forename: L
authors.initials: L
authors.lastname: Ottobrini
authors.forename: C
authors.initials: C
authors.lastname: Martelli
authors.forename: R
authors.initials: R
authors.lastname: Lui
authors.forename: L
authors.initials: L
authors.lastname: Madaschi
authors.forename: S
authors.initials: S
authors.lastname: Belloli
mesh_terms: D000465:Algorithms; D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging; D004867:Equipment Design; D005552:Forelimb / Q000000981:diagnostic imaging; D015902:Gamma Cameras; D007091:Image Processing, Computer-Assisted / Q000379:methods; D016013:Likelihood Functions; D008168:Lung / Q000000981:diagnostic imaging; D008495:Medical Oncology / Q000295:instrumentation; D051379:Mice; D011877:Radionuclide Imaging / Q000295:instrumentation / Q000379:methods