Cocaine-induced changes in affective state modulate the light-enhanced startle response.
In order to evaluate the influence of changes in affective state on light-enhanced startle, the effects of positive affect, induced by acute cocaine administration, and the effect of negative affect, induced by spontaneous cocaine withdrawal-induced anxiety, were studied. Acute cocaine administration decreased LES, whereas withdrawal from chronic cocaine administration exacerbated LES 24h after withdrawal, an effect indicative of increased anxiety. This exacerbated LES was reduced, but not back to normal, 4 days after withdrawal. The finding that both cocaine-induced positive and negative affect can be detected in LES, suggests that this may be a valuable tool in studying affect regulation in rodents.
Bijlsma
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Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and, Rudolf Magnus Institute of Neuroscience, Utrecht University, Sorbonnelaan 16, 3584 CA Utrecht, The Netherlands. E.Y.Bijlsma@uu.nl
Olivier
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B
Groenink
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D000339:Affect / Q000187:drug effects*; D000818:Animals; D001007:Anxiety / Q000209:etiology; D002491:Central Nervous System Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010775:Photic Stimulation; D051381:Rats; D013216:Reflex, Startle / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome; D013997:Time Factors; D014796:Visual Perception / Q000187:drug effects*
D002491:Central Nervous System Agents; D003042:Cocaine