Lessons from photoreceptors: turning off g-protein signaling in living cells.
Phototransduction in retinal rods is one of the most extensively studied G-protein signaling systems. In recent years, our understanding of the biochemical steps that regulate the deactivation of the rod's response to light has greatly improved. Here, we summarize recent advances and highlight some of the remaining puzzles in this model signaling system.
Burns
Marie E
ME
Departments of Ophthalmology and Vision Science, University of California, Davis, California, USA. meburns@ucdavis.edu
Pugh
Edward N
EN
D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism*; D051379:Mice; D017948:Retinal Rod Photoreceptor Cells / Q000502:physiology*; D014785:Vision, Ocular / Q000502:physiology*
D019204:GTP-Binding Proteins