title: Slipped capital femoral epiphysis: an ultrastructural study before and after osteosynthesis.
abstract: OBJECTIVE
  Several different theories have been proposed to explain the pathogenesis of slipped capital femoral epiphysis (SCFE). Using transmission electron microscopy (TEM), we carried out an ultrastructural study of core biopsy specimens of the physis at various stages of the disease.
  
  
  METHODS
  Core biopsies were performed in 6 patients with different forms of SCFE during the first operation, and in 3 of them when removing the osteosynthesis material before physeal closure. The specimens were prepared for TEM examination.
  
  
  RESULTS
  In 6 specimens obtained at first surgery, a marked distortion of the physeal architecture was observed. In 2 of the 3 specimens obtained at removal of the osteosynthesis material, the physis showed a more normal organization.
  
  
  CONCLUSIONS
  The improvement of the pathological alterations observed in the 2 cases after surgical intervention leads us to consider the possibility that when the growth plate is stabilized directly by pinning or indirectly by creating more optimal loading conditions with an intertrochanteric osteotomy, the morpho-functional characteristics of the physis can be restored and its growth process may resume.
authors.affiliation: Orthopaedics and Traumatology Division, Institute of Scientific Research, Bambino Gesù Children's Hospital, Rome.
authors.forename: Francesco
authors.initials: F
authors.lastname: Falciglia
authors.forename: Angelo Gabriele
authors.initials: AG
authors.lastname: Aulisa
authors.forename: Marco
authors.initials: M
authors.lastname: Giordano
authors.forename: Renata
authors.initials: R
authors.lastname: Boldrini
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Guzzanti
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002648:Child; D004839:Epiphyses, Slipped / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D005260:Female; D005269:Femur / Q000601:surgery; D006132:Growth Plate / Q000648:ultrastructure; D006801:Humans; D008297:Male; D046529:Microscopy, Electron, Transmission