title: Maxillary sinus augmentation with autologous bone harvested from the lateral maxillary wall combined with bovine-derived hydroxyapatite: clinical and histologic observations.
abstract: OBJECTIVE
  The aim of this study was to determine the clinical efficacy of a mixture of autologous bone harvested from the lateral wall of the maxilla using bone shavers and bovine-derived hydroxyapatite (HA) placed as a graft to elevate the maxillary sinus floor. The histological picture of tissue found in the sinus, the survival rate and the success of the implants were all evaluated.
  
  
  METHODS
  A total of 90 titanium implants were placed in 34 patients. In all of them, the lateral maxillary wall was harvested as a particulate bone graft, subsequently mixed with bovine-derived HA and packed in the sinus cavity. The lateral access window was then covered with a bioresorbable porcine-derived collagen membrane. In 32 sinuses, a two-stage surgery was performed, while in the remaining 10 cases a one-stage surgery was carried out. In the two-stage approach, 14 randomly selected biopsies were obtained at the time of implant insertion after a healing period of 9 months. The histological specimens were histologically and histomorphometrically evaluated.
  
  
  RESULTS
  One implant was lost, leading to a survival rate of 98.9%. The new bone consisted of lamellae of living bone contained osteocytes and in close contact with bovine bone particles that were partly infiltrated by newly formed bone. Bovine bone particle resorption could not be found. The histomorphometric analysis showed the following averages: 29% of newly formed bone and 21% of anorganic bovine bone. The marrow spaces made up the remaining 50% of the specimens.
  
  
  CONCLUSIONS
  Sinus lift graft with autologous bone harvested from the maxillary lateral wall combined with demineralized bovine bone leads to a predictable outcome regarding the amount of bone formation in sinus floor augmentation.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Facultad de Medicina y Odontología, Hospital Universitario Central de Asturias, Oviedo, Spain. jvicente@uniovi.es
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: de Vicente
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Hernández-Vallejo
authors.forename: Pelayo
authors.initials: P
authors.lastname: Braña-Abascal
authors.forename: Ignacio
authors.initials: I
authors.lastname: Peña
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods; D002417:Cattle; D003758:Dental Implantation, Endosseous; D017886:Durapatite; D005260:Female; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods; D006801:Humans; D008297:Male; D008437:Maxilla / Q000601:surgery; D008443:Maxillary Sinus / Q000601:surgery*; D008875:Middle Aged; D008903:Minerals; D013516:Oral Surgical Procedures, Preprosthetic; D011446:Prospective Studies
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008903:Minerals; D017886:Durapatite