Endothelial cells as targets for chylomicron remnants.
Endothelial dysfunction is characterised by pro-inflammatory/pro-coagulant changes in the endothelium and supports leukocyte adhesion and transmigration, key steps in early atherogenesis. There is emerging evidence that triacylglycerol-rich lipoproteins (TGRLs) present in the circulation during the postprandial phase influence vascular inflammation but the specific contribution of the remnant lipoprotein component of TGRLs is largely unexplored and the mechanistic basis of their actions poorly defined. This article provides a brief overview of the evidence supporting direct actions of these particles on endothelial cells and highlights the importance of their fatty acid composition and oxidative state as determinants of their cellular actions.
Dalla-Riva
Jonathan
J
Department of Veterinary Basic Sciences, Royal Veterinary College, Royal College Street, London NW1 0TU, UK.
Garonna
Elena
E
Elliott
Jonathan
J
Botham
Kathleen M
KM
Wheeler-Jones
Caroline P
CP
D000818:Animals; D053298:Chylomicron Remnants / Q000378:metabolism*; D042783:Endothelial Cells / Q000276:immunology / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D018836:Inflammation Mediators / Q000378:metabolism; D018384:Oxidative Stress
D053298:Chylomicron Remnants; D005227:Fatty Acids; D018836:Inflammation Mediators