title: [Necrotizing pneumonia by community-acquired, methicillin-resistant Staphylococcus aureus in Colombia].
abstract: The emergence of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) as a cause of severe infections has been described in the recent years. In 2006, the first report of skin and soft tissue infection by CA-MRSA was published in Colombia. Herein, two additional cases of CA-MRSA are reported with a clinical course characterized by rapid progression, prolonged stay in the intensive care unit and complication of pneumonia with the onset of empyema. Both adult patients developed acute renal failure, and were treated with linezolide; the subsequent clinical response showed adequate treatment response. Molecular characterization of the isolates indicated the presence of the mecA gene carrying the cassette SCCmec type IV and the production of the toxin panton-valentine leukocidin.
authors.affiliation: Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá, D.C, Colombia. chgomez@husi.org.co
authors.forename: Carlos Hernando
authors.initials: CH
authors.lastname: Gómez
authors.forename: Ana María
authors.initials: AM
authors.lastname: Perilla
authors.forename: Camilo
authors.initials: C
authors.lastname: González
authors.forename: Sandra Liliana
authors.initials: SL
authors.lastname: Valderrama
authors.forename: Natasha
authors.initials: N
authors.lastname: Vanegas
authors.forename: Bibiana
authors.initials: B
authors.lastname: Chavarro
authors.forename: Luis Carlos
authors.initials: LC
authors.lastname: Triana
authors.forename: José Roberto
authors.initials: JR
authors.lastname: Támara
authors.forename: Carlos Arturo
authors.initials: CA
authors.lastname: Alvarez
mesh_terms: D000081:Acetamides / Q000627:therapeutic use; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003105:Colombia / Q000453:epidemiology; D003131:Combined Modality Therapy; D017714:Community-Acquired Infections / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000601:surgery; D004322:Drainage; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation; D000069349:Linezolid; D008181:Lupus Nephritis / Q000601:surgery; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D008875:Middle Aged; D009336:Necrosis; D023303:Oxazolidinones / Q000627:therapeutic use; D011023:Pneumonia, Staphylococcal / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology* / Q000601:surgery; D011183:Postoperative Complications / Q000382:microbiology; D012121:Respiration, Artificial; D012772:Shock, Septic / Q000209:etiology; D013907:Thoracostomy; D014057:Tomography, X-Ray Computed
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid