title: Noninvasive activity-based control of an implantable rotary blood pump: comparative software simulation study.
abstract: A control algorithm for an implantable centrifugal rotary blood pump (RBP) based on a noninvasive indicator of the implant recipient's activity level has been proposed and evaluated in a software simulation environment. An activity level index (ALI)-derived from a noninvasive estimate of heart rate and the output of a triaxial accelerometer-forms the noninvasive indicator of metabolic energy expenditure. Pump speed is then varied linearly according to the ALI within a defined range. This ALI-based control module operates within a hierarchical multiobjective framework, which imposes several constraints on the operating region, such as minimum flow and minimum speed amplitude thresholds. Three class IV heart failure (HF) cases of varying severity were simulated under rest and exercise conditions, and a comparison with other popular RBP control strategies was performed. Pump flow increases of 2.54, 1.94, and 1.15 L/min were achieved for the three HF cases, from rest to exercise. Compared with constant speed control, this represents a relative flow change of 30.3, 19.8, and -15.4%, respectively. Simulations of the proposed control algorithm exhibited the effective intervention of each constraint, resulting in an improved flow response and the maintenance of a safe operating condition, compared with other control modes.
authors.affiliation: Graduate School of Biomedical Engineering, University of New South Wales, Sydney, New South Wales, Australia.
authors.forename: Dean M
authors.initials: DM
authors.lastname: Karantonis
authors.forename: Einly
authors.initials: E
authors.lastname: Lim
authors.forename: David G
authors.initials: DG
authors.lastname: Mason
authors.forename: Robert F
authors.initials: RF
authors.lastname: Salamonsen
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Ayre
authors.forename: Nigel H
authors.initials: NH
authors.lastname: Lovell
mesh_terms: D000465:Algorithms; D001783:Blood Flow Velocity; D003198:Computer Simulation; D006333:Heart Failure / Q000601:surgery*; D006339:Heart Rate; D006353:Heart-Assist Devices; D008955:Models, Cardiovascular; D011673:Pulsatile Flow; D012984:Software