Fanconi anemia and breast cancer susceptibility meet again.
A new study reports biallelic mutations in RAD51C in a Fanconi anemia-like disorder, while a second study reports monoallelic mutations in the same gene associated with increased breast cancer risk. These findings strengthen the link between Fanconi anemia and breast cancer-associated pathways.
Levy-Lahad
Ephrat
E
Medical Genetics Institute, Shaare Zedek Medical Center (Hebrew University), Jerusalem, Israel. lahad@szmc.org.il
D001943:Breast Neoplasms / Q000235:genetics*; D002648:Child; D003432:Cross-Linking Reagents / Q000494:pharmacology; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics; D005199:Fanconi Anemia / Q000235:genetics*; D005260:Female; D005816:Genetic Complementation Test; D020022:Genetic Predisposition to Disease; D006801:Humans; D008495:Medical Oncology / Q000379:methods; D008957:Models, Genetic; D009154:Mutation; D010051:Ovarian Neoplasms / Q000235:genetics; D011995:Recombination, Genetic
D003432:Cross-Linking Reagents; D004268:DNA-Binding Proteins; C448305:RAD51C protein, human