Thymine, adenine and lipoamino acid based gene delivery systems.
A novel class of thymine, adenine and lipoamino acid based non-viral carriers for gene delivery has been developed. Their ability to bind to DNA by hydrogen bonding was confirmed by NMR diffusion, isothermal titration calorimetry and transmission electron microscopy experiments.
Skwarczynski
Mariusz
M
The University of Queensland, School of Chemistry and Molecular Biosciences, Qld 4072, Brisbane, Australia.
Ziora
Zyta M
ZM
Coles
Daniel J
DJ
Lin
I-Chun
IC
Toth
Istvan
I
D000225:Adenine / Q000737:chemistry* / Q000378:metabolism; D000596:Amino Acids / Q000737:chemistry* / Q000378:metabolism; D004247:DNA / Q000008:administration & dosage* / Q000378:metabolism; D018014:Gene Transfer Techniques; D006860:Hydrogen Bonding; D008055:Lipids / Q000737:chemistry; D013941:Thymine / Q000737:chemistry* / Q000378:metabolism
D000596:Amino Acids; D008055:Lipids; D004247:DNA; D000225:Adenine; D013941:Thymine