The effects of exercise therapy on delirium in cancer patients: a retrospective study.
OBJECTIVE
The present study aimed to investigate the effects of exercise therapy on delirium in cancer patients.


METHODS
We conducted a retrospective study of cancer patients who were admitted to Kyoto University Hospital and referred to the Palliative Care Team. Subjects were divided into two groups [an exercise therapy group (EG) and a non-exercise therapy group (NG)] according to whether exercise therapy was being used for early ambulation at the time delirium occurred. To examine whether any characteristics differed significantly between the two groups, we also compared age, performance status, alcohol use, existence of metastatic brain tumors or preexisting CNS illnesses, levels of opioid exposure, and survival time from the onset of delirium. Moreover, we investigated whether there were differences in antipsychotic drug doses administered between these two groups in order to better analyze the specific effects of exercise therapy on the course of delirium.


RESULTS
EG and NG groups did not differ significantly in terms of any characteristics. The administered dose of antipsychotic drugs was significantly lower in the EG group versus the NG group (2.198 mg versus 5.533 mg, p = 0.036). In comparison, the dose of opioids used did not differ significantly between the two study groups.


CONCLUSIONS
Given the relatively low antipsychotic doses used, it is conceivable that delirium symptoms were attenuated in patients who received exercise therapy. This study suggests that exercise therapy may be useful as one environmental/supportive intervention for delirium.
Tatematsu
Noriatsu
N
Human Health Science, Graduate School of Medicine, Kyoto University, Shogoin-Kawahara-cho, Sakyo-ku, Kyoto, Japan, 606-8507. noriatsu.t@ay4.ecs.kyoto-u.ac.jp
Hayashi
Akiko
A
Narita
Keiichi
K
Tamaki
Akira
A
Tsuboyama
Tadao
T
D000367:Age Factors; D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects; D014150:Antipsychotic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D003693:Delirium / Q000209:etiology / Q000628:therapy*; D004305:Dose-Response Relationship, Drug; D005081:Exercise Therapy / Q000379:methods*; D005260:Female; D006785:Hospitals, University; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000628:therapy; D010166:Palliative Care / Q000379:methods; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate
D000701:Analgesics, Opioid; D014150:Antipsychotic Agents