Orion: a glimpse of hope in life span extension?
Orion is a multicomponent drug based on derivatives of taurocholic acid and several other compounds. Application of Orion into the feeding medium of Drosophila melanogaster resulted in increased life span and survival at stressful conditions. Two paradoxical features of the drug should be stressed: The "age-threshold" (life span extension was observed only when the drug was applied starting from the second half of life) and induction of "centenarian" flies (older 100 days). Orion enhanced survival at heat shock (38 degrees C) and acidic (pH = 1.6) or alkaline (pH = 11.8) feeding mediums, but not at oxidative stresses modeled by 100% oxygen or application of hydrogen peroxide (H(2)O(2)).
Muradian
K
K
Institute of Gerontology of Academy of Medical Sciences of Ukraine, Kiev, Ukraine. kkm@geront.kiev.ua
Bondar
V
V
Bezrukov
V
V
Zhukovsky
O
O
Polyakov
V
V
Utko
N
N
D000222:Adaptation, Physiological / Q000187:drug effects; D000821:Animal Feed; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D006358:Hot Temperature; D006861:Hydrogen Peroxide / Q000378:metabolism; D008017:Life Expectancy; D008136:Longevity / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D013312:Stress, Physiological / Q000187:drug effects; D013534:Survival; D013656:Taurocholic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*
D004338:Drug Combinations; D013656:Taurocholic Acid; D006861:Hydrogen Peroxide