title: Insecticidal activity of camptothecin against Nilaparvata lugens, Brevicoryne brassicae, and Chilo suppressalis.
abstract: Greenhouse tests showed that 0.2% camptothecin emulsifiable concentrate (EC) has strong contact toxicity to three agricultural pests, with LC50 and LC90 values of 0.1-0.6 and 0.4-5.0 mg liter(-1), respectively. The descending order of susceptibility was Nilaparvata lugens (Ståhl) > Brevicoryne brassicae (L.) > Chilo suppressalis (Walker). Field tests showed that the corrected mortality of B. brassicae and N. lugens was 94.6 and 69.1%, respectively, which was not significantly different from that with 10% imidacloprid WP at 98.4 and 63.4%, respectively. The corrected mortality of C. suppressalis was 85.8%, which was not significantly different from that with 5% Regent SC at 93.0%. Camptothecin EC showed no acute oral toxicity to the mouse (LD50 > 5000 mg/kg) nor acute dermal toxicity (LD50 > 2000 mg/kg).
authors.affiliation: School of Forestry and Biotechnology, Zhejiang Forestry College, Lin-an, 311300, People's Republic of China.
authors.forename: Jianyi
authors.initials: J
authors.lastname: Ma
authors.forename: Senmiao
authors.initials: S
authors.lastname: Tong
authors.forename: Pinwei
authors.initials: P
authors.lastname: Wang
authors.forename: Wenli
authors.initials: W
authors.lastname: Liao
authors.forename: Hongbo
authors.initials: H
authors.lastname: Liu
authors.forename: Liqin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001042:Aphids / Q000187:drug effects*; D002166:Camptothecin / Q000494:pharmacology*; D005260:Female; D006430:Hemiptera / Q000187:drug effects*; D007093:Imidazoles / Q000494:pharmacology; D007306:Insecticides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009036:Moths / Q000187:drug effects*; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000494:pharmacology
chemical_list: D007093:Imidazoles; D007306:Insecticides; D000073943:Neonicotinoids; D009574:Nitro Compounds; C082359:imidacloprid; D002166:Camptothecin