[Airway resistance and urinary LTE4 in children with bronchopulmonary dysplasia. Preliminary report].
OBJECTIVE
To assess airway resistance values and urinary leukotriene E4 (LTE4) concentrations before and after salbutamol inhalation in children with bronchopulmonary dysplasia (BPD).


METHODS
Children with BPD were cross-sectionally studied to measure airway resistance by the interrupter technique (Rint), before and after inhaling 200 ig salbutamol, and to quantify urinary leukotriene E4 (LTE4) by immunoassay.


RESULTS
Thirty one children with BPD (15 females) aged between 3 months and 9 years were studied. Our results showed that LTE4 did not correlate with Rint values (r = 0.12, p = 0.52) even after adjusting by gender, atopy history, steroid use, and gastroesophageal reflux. Likewise, LTE4 did not correlate with the degree of the airway response to salbutamol (r = -0.13, p = 0.50). A strong inverse association between age and Rint (r = -0.58, p < 0.001) was observed.


CONCLUSIONS
We concluded that urinary LTE, did not correlate with airway resistance or with the response to a bronchodilator drug in children with BPD, suggesting that leukotrienes are not involved in airway obstruction in this disease.
Vargas
Mario H
MH
Unidad de Investigación Médica en Enfermedades Respiratorias y Departamento de Neumología, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, DF Mexico. mhvargasb@yahoo.com.mx
Ojeda-Luna
Nancy Guadalupe
NG
Furuya
María Elena Y
ME
Arreola-Ramírez
José Luis
JL
Zúñiga-Vázquez
Guillermo
G
D000293:Adolescent; D000403:Airway Resistance; D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology* / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000503:physiopathology / Q000652:urine; D017999:Leukotriene E4 / Q000652:urine*; D008297:Male; D011446:Prospective Studies
D017999:Leukotriene E4