title: High frequency hearing loss following treatment for nasopharyngeal carcinoma.
abstract: OBJECTIVE
  To evaluate the prevalence, severity and differences of high frequency hearing loss in nasopharyngeal carcinoma patients after curative treatment by radiotherapy alone and chemoradiation.
  
  
  METHODS
  Pure tone audiometry was done in nasopharyngeal carcinoma patients who came back to follow-up after curative treatment during the year 2003 and 2004. The patients were divided into three groups, the first group received radiation treatment only, the second group received radiation and cisplatin chemotherapy, and the third group received radiation and carboplatin chemotherapy
  
  
  RESULTS
  Of 192 patients with a mean age 49.9 years, mean radiation dose 6,951.5 cGy, mean follow-up period 3 years and 9 months, 93.8% showed bilateral high frequency hearing loss. There were statistically significant differences in the high frequency hearing threshold between the second group versus the first and the third group.
  
  
  CONCLUSIONS
  Clinicians should inform patients of the risk of hearing loss, particularly the treatment with cisplatin. Hearing test should be a routine test after treatment completion.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
authors.forename: Yupa
authors.initials: Y
authors.lastname: Sumitsawan
authors.forename: Vasana
authors.initials: V
authors.lastname: Vaseenon
authors.forename: Charuk
authors.initials: C
authors.lastname: Hanprasertpong
authors.forename: Kannika
authors.initials: K
authors.lastname: Roongrotwattanasiri
authors.forename: Imjai
authors.initials: I
authors.lastname: Chitapanarux
authors.forename: Suwicha
authors.initials: S
authors.lastname: Isaradisaikul
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D001301:Audiometry, Pure-Tone; D016190:Carboplatin / Q000009:adverse effects; D002648:Child; D002945:Cisplatin / Q000009:adverse effects; D003430:Cross-Sectional Studies; D005260:Female; D006316:Hearing Loss, High-Frequency / Q000453:epidemiology*; D006319:Hearing Loss, Sensorineural / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D015995:Prevalence; D011879:Radiotherapy Dosage; D013785:Thailand / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents; D016190:Carboplatin; D002945:Cisplatin