title: The effect of leg hyperthermia using far infrared rays in bedridden subjects with type 2 diabetes mellitus.
abstract: We examined the effect of leg hyperthermia on oxidative stress in bedridden subjects with type 2 diabetes mellitus using 15-min sessions of far infrared rays over a two-week period. Four subjects (male 1, female 3) incapacitated by a stroke were recruited for this study. All patients were admitted to Takahashi Central Hospital and ate the same hospital meals. Fasting plasma glucose, HbA1c, tumor necrosis factor (TNF)alpha, free fatty acid, leptin, adiponectin and plasma 8-epi-prostaglandin F2alpha (8-epi-PGF2alpha) levels as a marker of oxidative stress were measured on admission, just before and 2 weeks after local heating of the leg. Results showed that plasma total 8-epi-PGF2alpha levels were decreased significantly while TNFalpha levels were increased significantly. On the other hand, glucose, HbA1c, free fatty acid, leptin and adiponectin levels were not changed during the study period. These results suggest that repeated leg hyperthermia may protect against oxidative stress.
authors.affiliation: Department of Physical Therapy, School of Health Science, KIBI International University, Takahashi, Okayama 716-8508, Japan. kawaura@kiui.ac.jp
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kawaura
authors.forename: Noritoshi
authors.initials: N
authors.lastname: Tanida
authors.forename: Masato
authors.initials: M
authors.lastname: Kamitani
authors.forename: Junichi
authors.initials: J
authors.lastname: Akiyama
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Mizutani
authors.forename: Naoko
authors.initials: N
authors.lastname: Tsugawa
authors.forename: Toshio
authors.initials: T
authors.lastname: Okano
authors.forename: Eiji
authors.initials: E
authors.lastname: Takeda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D007259:Infrared Rays; D007333:Insulin Resistance; D007866:Leg; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000502:physiology; D018384:Oxidative Stress; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D014409:Tumor Necrosis Factor-alpha; D052250:Nitric Oxide Synthase Type III