Trimethopim-sulfamethoxazole compared with benzathine penicillin for treatment of impetigo in Aboriginal children: a pilot randomised controlled trial.
We conducted a pilot randomized controlled trial comparing trimethoprim-sulfamethoxazole to benzathine penicillin for treatment of impetigo in Aboriginal children. Treatment was successful in 7 of 7 children treated with trimethoprim-sulfamethoxazole and 5 of 6 treated with benzathine penicillin. Trimethoprim-sulfamethoxazole achieved microbiological clearance and healing of sores from which beta-hemolytic streptococci and community-associated methicillin-resistant Staphylococcus aureus were initially cultured.
Tong
Steven Y C
SY
Menzies School of Health Research, Charles Darwin University, Darwin, Australia. steven.tong@menzies.edu.au
Andrews
Ross M
RM
Kearns
Therese
T
Gundjirryirr
Rosalyn
R
McDonald
Malcolm I
MI
Currie
Bart J
BJ
Carapetis
Jonathan R
JR
D000284:Administration, Oral; D000293:Adolescent; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007169:Impetigo / Q000188:drug therapy* / Q000382:microbiology; D007223:Infant; D007273:Injections, Intramuscular; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus; D015876:Northern Territory; D010401:Penicillin G Benzathine / Q000008:administration & dosage / Q000627:therapeutic use*; D010865:Pilot Projects; D013297:Streptococcus pyogenes; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage / Q000627:therapeutic use*
D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D010401:Penicillin G Benzathine