[Comparative study of efficacy and safety between propofol and midazolam for sedation during colonoscopy].
OBJECTIVE
To compare safety and efficacy of propofol with midazolam for deep sedation in the colonoscopy.


METHODS
In a prospective way, 66 patients underwent colonoscopy--50 patients received propofol in an average dose of 3,25 mgxkg-1 and 16 patients (control group) received midazolam with total average dose of 2,05 mgxkg-1. The dose of medication was titrated according to patient need. The analyzed cardiovascular and respiratory parameters were: oxygen saturation, systolic and diastolic blood pressure and heart rate. After the colonoscopy, a survey with a visual scale from 0 to 10 and questions regarding the pain, discomfort and satisfaction was applied. The statistics analyzed by the t Student test.


RESULTS
Groups were similar regarding the age, weight, sex and physical conditions (ASA grade). None of the patient required emergencial treatment. None of the cardiovascular and respiratory parameters with statistics differences produced hemodynamic repercussions. The pain and satisfaction parameters showed no significant difference between the midazolam group and propofol group The discomfort parameter during the colonoscopic showed significant difference (p=0,038) between the midazolam group (score 2,81) and propofol group (score 1,18) and all the patients which had presented paradoxal excitation (25%) in this group reported discomfort.


CONCLUSIONS
The cardiovascular and respiratory parameters variation, even when different between groups, didn't produced clinical repercussions. The pain and satisfaction parameters showed no significant difference between groups. It was demonstrated that the midazolam group referred more discomfort than the propofol group.
Ivano
Flávio Heuta
FH
Programa de Pós-Graduação em Clínica Cirúrgica, Universidade Federal do Paraná, Curitiba, PR, BR.
Romeiro
Paula Christina Marra
PC
Matias
Jorge Eduardo Fouto
JE
Baretta
Giorgio Alfredo Pedroso
GA
Kay
Antonio Katsumi
AK
Sasaki
Carlos Akio
CA
Nakamoto
Regina
R
Tambara
Elizabeth Milla
EM
D000328:Adult; D000368:Aged; D003113:Colonoscopy; D054810:Deep Sedation; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000627:therapeutic use*; D008297:Male; D008874:Midazolam / Q000627:therapeutic use*; D008875:Middle Aged; D015742:Propofol / Q000627:therapeutic use*; D011446:Prospective Studies
D006993:Hypnotics and Sedatives; D008874:Midazolam; D015742:Propofol