title: Biological roles of Acid and neutral sphingomyelinases and their regulation by nitric oxide.
abstract: Generation of the pleiotropic sphingolipid mediator ceramide by acid and neutral sphingomyelinases is a key event in many cellular pathophysiological processes including survival, death, proliferation, and differentiation, in which also the short-lived gaseous messenger nitric oxide plays a crucial role. This review describes how the outcome of these key cellular processes is finely tuned by surprising and complex interplays among nitric oxide, ceramide, and their effectors.
authors.affiliation: Unit of Clinical Pharmacology, Department of Preclinical Sciences, University Hospital Luigi Sacco, Università di Milano, Milano, Italy.
authors.forename: Cristiana
authors.initials: C
authors.lastname: Perrotta
authors.forename: Emilio
authors.initials: E
authors.lastname: Clementi
mesh_terms: D000818:Animals; D004789:Enzyme Activation / Q000502:physiology*; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism*
chemical_list: D009569:Nitric Oxide; D013108:Sphingomyelin Phosphodiesterase