title: Late hepatic metastasis in the evolution of gastrointestinal stromal tumors.
abstract: Gastro-intestinal stromal tumours develop in the digestive tract wall, in the undifferentiated mesenchymal cells with a starting point at the level of the interstitial cells of Cajal. Gastro-intestinal stromal tumours often lead to peritoneal and hepatic metastasis. Assessment of aggressive behavior of GIST is difficult. A special attention should be paid to localization, serosal invasion, mucous ulceration, size of the tumor and mitotic index, in order to set the prognosis of the patient. We here by present two cases of gastro-intestinal stromal tumours one with gastric location and one jejunal tumor with ulceration and hemorrhage, of small sizes, initially diagnosed as benign but developing in the late evolution liver metastases. Right lobectomy was performed in both cases, in one case being associated with segment II resection. The patients have been followed-up at oncology and they received Imatinib, and when the metastasis reappeared was reintroduced, increasing the dose.
authors.affiliation: Surgical Clinic No. 2, Tg. Mures, and Medical Clinic No. 4, Tg. Mures, Mures County, Romania. barativadar@yahoo.com
authors.forename: Bara
authors.initials: B
authors.lastname: Tivadar
authors.forename: Bancu
authors.initials: B
authors.lastname: Serban
authors.forename: Muresan
authors.initials: M
authors.lastname: Mircea
authors.forename: Bara
authors.initials: B
authors.lastname: Tivadar
authors.forename: Azamfirei
authors.initials: A
authors.lastname: Leonard
authors.forename: Podeanu
authors.initials: P
authors.lastname: Daniela
authors.forename: Muresan
authors.initials: M
authors.lastname: Simona
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001549:Benzamides; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D006498:Hepatectomy; D006801:Humans; D000068877:Imatinib Mesylate; D007580:Jejunal Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D007889:Leiomyoma / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate