Bone substitute as an on-lay graft on rat tibia.
OBJECTIVE
To investigate the capacity of Cerament, an injectable bone substitute, to guide bone generation from a cortical surface.


METHODS
Cerament was applied to the cortical surface of rat tibiae and investigated histologically after 3, 6 and 12 weeks, using a procedure similar to that performed in sham-operated rats.


RESULTS
In both groups, the thickness of the bone cortex increased significantly from 473 + or - 58 microm (mean + or - SD) at day 0 to 1193 + or - 255 microm (Cerament) and 942 + or - 323 microm (sham) after 3 weeks. In the Cerament group, the new bone thickness remained constant (1258 + or - 288 microm) until the end of the experiment at 12 weeks, while the sham group demonstrated a return to initial cortical thickness (591 + or - 73 microm) at 12 weeks. The newly formed bone in the Cerament group was highly trabecular after 3 weeks but attained a normal trabecular structure of the cortex after 12 weeks.


CONCLUSIONS
Cerament may guide bone generation from an intact cortical bone surface. Although bone remodeling speed may differ between rats and humans, our study indicates that Cerament may become a useful alternative to autologous bone, both to fill defects and to increase bone volume by cortical augmentation.
Truedsson
A
A
Department of Oral Pathology, Faculty of Odontology, Malmö University, SE-205 06 Malmö, Sweden. anna.truedsson@mah.se
Wang
J S
JS
Lindberg
P
P
Gordh
M
M
Sunzel
B
B
Warfvinge
G
G
D000818:Animals; D001861:Bone Regeneration; D018786:Bone Substitutes; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013977:Tibia / Q000601:surgery
D018786:Bone Substitutes