Enantioanalysis of (-)butaclamol using vancomycin and teicoplanin as chiral selectors.
Butaclamol is an antipsychotic drug used in the treatment of schizophrenia. The macrocyclic antibiotics, vancomycin and teicoplanin, are proposed as chiral selectors for the design of the enantioselective, potentiometric membrane electrodes (EPMEs) for the assay of (-)butaclamol. The slopes of the electrodes are near-Nernstian for the assay of (-) butaclamol with linear concentration ranges between 10(-10) and 10(-7) mol/L and between 10(-9) and 10(-7) mol/L for vancomycin and teicoplanin based EPMEs. Limits of detections varied. The electrodes were used reliably for the enantioanalysis of (-) butaclamol in serum samples.
Stefan-van Staden
Raluca-Ioana
RI
National Institute of Research for Electrochemistry and Condensed Matter, Bucharest, Romania. iustinavanstaden@yahoo.com
Nhlapo
Nontete Suzan
NS
van Staden
Jacobus Frederick
JF
Aboul-Enein
Hassan Y
HY
D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000737:chemistry; D014150:Antipsychotic Agents / Q000032:analysis* / Q000737:chemistry*; D002069:Butaclamol / Q000032:analysis* / Q000737:chemistry*; D004566:Electrodes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D011199:Potentiometry; D013237:Stereoisomerism; D017334:Teicoplanin / Q000032:analysis* / Q000737:chemistry; D014640:Vancomycin / Q000032:analysis* / Q000737:chemistry
D000900:Anti-Bacterial Agents; D014150:Antipsychotic Agents; D017334:Teicoplanin; D014640:Vancomycin; D002069:Butaclamol