[Impact of TNF-alpha gene polymorphism, development of atherogenic dyslipidemia and risk of atherosclerosis].
In this 5-year prospective cohort study, 92 clinically healthy subjects (42 men and 50 women) were screened for G-308A polymorphism of the TNF-alpha gene. Fasting serum lipid levels and carotid intima-media thickness (IMT) were measured. Triglyceride levels in the GA+AA group were significantly (more than 3-fold) higher than in GG genotype patients. Patients in the former group had apolipoprotein index above 1 twice more frequently in the latter. The 5-year probability of atherosclerosis in GA+AA male patients was 55.9 +/- 15.4% vs. 9.1 +/- 6.1% in GG men (p < 0.001). The presence of A allele in TNFa gene was associated with a 9 times higher risk of early atherosclerosis estimated using the multivariate stepwise Cox regression model.
Roĭtenberg
G E
GE
Sharkhun
O O
OO
Ushakova
T I
TI
Serebriakova
O E
OE
D000328:Adult; D050197:Atherosclerosis / Q000175:diagnosis / Q000235:genetics*; D050171:Dyslipidemias / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic; D011379:Prognosis; D016016:Proportional Hazards Models; D012306:Risk; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D014409:Tumor Necrosis Factor-alpha