title: Association studies on the porcine RETN, UCP1, UCP3 and ADRB3 genes polymorphism with fatness traits.
abstract: Searching for effects of candidate gene polymorphisms on fatness traits is an important goal for pig industry. In this study we evaluated polymorphism of four porcine genes involved in energy metabolism (RETN, UCP1, UCP3 and ADRB3). Moreover, their association with fat deposition traits was analyzed in two breeds (Polish Landrace, Polish Large White) and a Polish synthetic line (L990). Altogether, five SNPs were identified, including two novel ones in the 5'-flanking region of the RETN gene and a novel missense substitution in the UCP3. Distribution of these polymorphisms in the studied five breeds and the synthetic line was not uniform. Two of the analyzed SNPs: g.-178G>A in the RETN and g.946C>T in the UCP3 gene revealed a significant association with abdominal fat weight or backfat thickness. Such associations were not observed for the UCP1 or ADRB3 gene polymorphisms. Our study showed that polymorphisms of the UCP3 and RETN genes are potentially associated with porcine fatness traits.
authors.affiliation: Department of Genetics and Animal Breeding , Poznan University of Life Sciences, Wolynska 33, 60-637 Poznan, Poland.
authors.forename: Jakub
authors.initials: J
authors.lastname: Cieslak
authors.forename: Joanna
authors.initials: J
authors.lastname: Nowacka-Woszuk
authors.forename: Magdalena
authors.initials: M
authors.lastname: Bartz
authors.forename: Honorata
authors.initials: H
authors.lastname: Fijak-Nowak
authors.forename: Maria
authors.initials: M
authors.lastname: Grzes
authors.forename: Maciej
authors.initials: M
authors.lastname: Szydlowski
authors.forename: Marek
authors.initials: M
authors.lastname: Switonski