title: Additional candidates to conventional genes susceptible for lung cancer and changing trend in Japan.
abstract: The polymorphism of CYP1A1*2A or CYP1A1*2B, and the linkage of CYP1A1*2A, CYP1A1*2B, GSTM1 and GSTT1 polymorphisms have been established as susceptible genes or gene-gene interactions of tobacco-related lung cancer. New candidate genes susceptible for lung cancer such as NQO1 (NAD(P)H:quinine oxidoreductase), NAT2 (N-acetyltransferase 2), and several others have been reported. In the present review we focus on new candidate genes susceptible for lung cancer, then examine all Japanese references by meta-analysis on susceptible genes over the past 20 years, and discuss whether new candidates and changing trend in Japan could be caused by environmental change.
authors.affiliation: Department of Internal Medicine, Sanno Hospital, International University of Health and Welfare, Tokyo 107-0052, Japan. iokazaki@iuhw.ac.jp
authors.forename: Isao
authors.initials: I
authors.lastname: Okazaki
authors.forename: Minoru
authors.initials: M
authors.lastname: Sugita
authors.forename: Hideaki
authors.initials: H
authors.lastname: Matsuki
authors.forename: Syed Muhammad Baqui
authors.initials: SM
authors.lastname: Billah
authors.forename: Tetsu
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D044466:Asian People / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000208:ethnology* / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology*; D009363:Neoplasm Proteins / Q000235:genetics*
chemical_list: D009363:Neoplasm Proteins