title: Evidence for a positive role of PtdIns5P in T-cell signal transduction pathways.
abstract: Phosphatidylinositol 5-phosphate (PtdIns5P) is emerging as a potential lipid messenger involved in several cell types, from plants to mammals. Expression of IpgD, a PtdIns(4,5)P(2) 4-phosphatase induces Src kinase and Akt, but not ERK activation and enhances interleukin II promoter activity in T-cells. Expression of a new PtdIns5P interacting domain blocks IpgD-induced T-cell activation and selective signaling molecules downstream of TCR triggering. Altogether, these data suggest that PtdIns5P may play a sensor function in setting the threshold of T-cell activation and contributing to maintain T-cell homeostasis.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Unité 891, Centre de Recherche en Cancérologie de Marseille, Marseille, France.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Guittard
authors.forename: Eva
authors.initials: E
authors.lastname: Mortier
authors.forename: Hélène
authors.initials: H
authors.lastname: Tronchère
authors.forename: Guylène
authors.initials: G
authors.lastname: Firaguay
authors.forename: Audrey
authors.initials: A
authors.lastname: Gérard
authors.forename: Pascale
authors.initials: P
authors.lastname: Zimmermann
authors.forename: Bernard
authors.initials: B
authors.lastname: Payrastre
authors.forename: Jacques A
authors.initials: JA
authors.lastname: Nunès
mesh_terms: D006801:Humans; D007376:Interleukin-2 / Q000378:metabolism; D008213:Lymphocyte Activation; D018129:Phosphatidylinositol Phosphates / Q000502:physiology*; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D010944:Plants / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000378:metabolism*; D019061:src-Family Kinases / Q000378:metabolism
chemical_list: D007376:Interleukin-2; D018129:Phosphatidylinositol Phosphates; D011948:Receptors, Antigen, T-Cell; C113567:phosphatidylinositol 5-phosphate; D019061:src-Family Kinases; D051057:Proto-Oncogene Proteins c-akt; D010744:Phosphoric Monoester Hydrolases