Developing an anion host for lipid A binding and antibacterial activity.
New structural amphiphiles 2a and 2b bind the diphosphate lipid A anion and show potential as lead compounds for the development of novel antibacterial agents.
Henderson
Luke C
LC
School of Life and Environmental Sciences, Deakin University, Geelong, 3217, VIC, Australia.
Li
Jian
J
Nation
Roger L
RL
Velkov
Tony
T
Pfeffer
Frederick M
FM
D000151:Acinetobacter Infections / Q000188:drug therapy; D040981:Acinetobacter baumannii / Q000187:drug effects; D000838:Anions / Q000737:chemistry / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006801:Humans; D008050:Lipid A / Q000737:chemistry / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013501:Surface-Active Agents / Q000737:chemistry* / Q000494:pharmacology*
D000838:Anions; D000900:Anti-Bacterial Agents; D008050:Lipid A; D013501:Surface-Active Agents