title: One-pot synthesis of amine-substituted aryl sulfides and benzo[b]thiophene derivatives.
abstract: A series of amine-substituted aryl sulfides have been synthesized from nitroaryl halides via a simple one-pot procedure involving metal-free C-S cross-coupling and in situ nitro group reduction. Various nitroaryl halides were reacted with thiols in recyclable poly(ethylene glycol) to afford the amine-substituted aryl sulfides in high yield. Additionally, the cross-coupling reactions of nitro- and aldehyde-substituted aryl halides with benzyl thiols under the same reaction conditions were demonstrated to afford benzothiazole and phenylbenzo[b]thiophene derivatives.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors.forename: Zhongyu
authors.initials: Z
authors.lastname: Duan
authors.forename: Sadananda
authors.initials: S
authors.lastname: Ranjit
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Liu
mesh_terms: D000588:Amines / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism; D013440:Sulfides / Q000138:chemical synthesis* / Q000737:chemistry; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D013440:Sulfides; D013876:Thiophenes; C088015:benzothiophene