title: Functional activity of rabbit salivary glands in reduced and restored regional arterial blood supply conditions.
abstract: BACKGROUND
  Although the vascular pathology of carotid arteries is widespread, the function of salivary glands in reduced arterial flow conditions is not much investigated clinically and in experiments. At the same time blood supply is a keystone to normal functioning of every organ and especially of salivary secretion. The aim of this study was to estimate functional activity of salivary glands in reduced and restored blood supply conditions in experiment by sialoscintigraphy which is an approved method for functional assessment of salivary glands.
  
  
  METHODS
  The ligature of a. carotis communis dextra was performed on 20 Californian rabbits. After 28 days sialoscintigraphy with Tc99 pertechnetate and revascularization through resection of the occluded part of a. carotis communis and reconstruction with venous autograft was performed. One month later sialoscintigraphy was done.
  
  
  RESULTS
  The functional activity of rabbit salivary glands after the ligature of a. carotis communis is strongly depressed. The revascularized glands accumulated isotope slowly, but the level of accumulation was higher than on the control side.
  
  
  CONCLUSIONS
  The ligature and reconstruction of a common carotid artery on rabbits confirm the important role of the arterial blood supply in functional activity of salivary glands and may be an appropriate experimental model for investigation of ischemic disease of salivary glands.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Riga Stradins University, Latvia. stamersons@inbox.lv
authors.forename: Kaspars
authors.initials: K
authors.lastname: Stamers
authors.forename: Andrejs
authors.initials: A
authors.lastname: Skagers
authors.forename: Kalvis
authors.initials: K
authors.lastname: Pastars
authors.forename: Nonna
authors.initials: N
authors.lastname: Tomisheva
authors.forename: Maija
authors.initials: M
authors.lastname: Ratniece
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D002341:Carotid Artery Thrombosis / Q000503:physiopathology / Q000601:surgery; D017536:Carotid Artery, Common / Q000601:surgery; D007511:Ischemia / Q000503:physiopathology; D007601:Jugular Veins / Q000637:transplantation; D008026:Ligation; D008297:Male; D011817:Rabbits; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D019651:Plastic Surgery Procedures; D012039:Regional Blood Flow / Q000502:physiology; D012469:Salivary Glands / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000378:metabolism; D012636:Secretory Rate / Q000502:physiology; D013670:Sodium Pertechnetate Tc 99m; D013997:Time Factors
chemical_list: D019275:Radiopharmaceuticals; D013670:Sodium Pertechnetate Tc 99m