The direct catalytic asymmetric aldol reaction.
Asymmetric aldol reactions are a powerful method for the construction of carbon-carbon bonds in an enantioselective fashion. Historically this reaction has been performed in a stoichiometric fashion to control the various aspects of chemo-, diastereo-, regio- and enantioselectivity, however, a more atom economical approach would unite high selectivity with the use of only a catalytic amount of a chiral promoter. This critical review documents the development of direct catalytic asymmetric aldol methodologies, including organocatalytic and metal-based strategies. New methods have improved the reactivity, selectivity and substrate scope of the direct aldol reaction and enabled the synthesis of complex molecular targets (357 references).
Trost
Barry M
BM
Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA. bmtrost@stanford.edu
Brindle
Cheyenne S
CS
D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D013237:Stereoisomerism
D000438:Alcohols; D007659:Ketones; D008670:Metals