title: Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum.
abstract: Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Piper nigrum. They are (E)-1-[3',4'-(methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). These compounds were isolated using chromatographic methods and their structures were elucidated using MS, IR and NMR techniques.
authors.affiliation: Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia. gwen@science.upm.edu.my
authors.forename: Gwendoline Cheng Lian
authors.initials: GC
authors.lastname: Ee
authors.forename: Chyi Meei
authors.initials: CM
authors.lastname: Lim
authors.forename: Mawardi
authors.initials: M
authors.lastname: Rahmani
authors.forename: Khozirah
authors.initials: K
authors.lastname: Shaari
authors.forename: Choon Fah Joseph
authors.initials: CF
authors.lastname: Bong
mesh_terms: D000470:Alkaloids / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D052117:Benzodioxoles / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D029222:Piper nigrum / Q000737:chemistry*; D010880:Piperidines / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: C551082:5-(3,4-(methylenedioxy)phenyl)-pent-2-ene piperidine; D000470:Alkaloids; D000970:Antineoplastic Agents; D052117:Benzodioxoles; D005231:Fatty Acids, Unsaturated; D010880:Piperidines; D053284:Polyunsaturated Alkamides; C008778:pellitorine; C008922:piperine