title: Non-heme iron(II/III) complexes that model the reactivity of lipoxygenase with a redox switch.
abstract: Three ferrous/ferric complexes of a N6 hexadentate ligand, N,N,N',N'-tetrakis(2-benzimidazolyl-methyl)ortho-diamine-trans-cyclohexane (ctb), [Fe(II)(ctb)](ClO(4))(2).EtOH (), [Fe(III)(OEt)(Hctb)](ClO(4))(3).EtOH (), and [Fe(III)(OMe)(Hctb)](ClO(4))(3).3MeOH.4.5H(2)O (), were synthesized and characterized as models of lipoxygenase. The lipoxygenase activities of the complexes were checked and the results indicate that ferrous complex is inactive while ferric alkoxide complexes and show catalytic activity via the hydrogen atom abstraction reaction mechanism.
authors.affiliation: Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China.
authors.forename: Fusheng
authors.initials: F
authors.lastname: Mei
authors.forename: Chunping
authors.initials: C
authors.lastname: Ou
authors.forename: Guiling
authors.initials: G
authors.lastname: Wu
authors.forename: Li
authors.initials: L
authors.lastname: Cao
authors.forename: Fang
authors.initials: F
authors.lastname: Han
authors.forename: Xianggao
authors.initials: X
authors.lastname: Meng
authors.forename: Ji
authors.initials: J
authors.lastname: Li
authors.forename: Dongfeng
authors.initials: D
authors.lastname: Li
authors.forename: Zhanru
authors.initials: Z
authors.lastname: Liao
mesh_terms: D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005290:Ferric Compounds / Q000737:chemistry*; D005296:Ferrous Compounds / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D008024:Ligands; D008084:Lipoxygenase / Q000737:chemistry* / Q000378:metabolism; D008956:Models, Chemical; D008968:Molecular Conformation; D010084:Oxidation-Reduction
chemical_list: D056831:Coordination Complexes; D005290:Ferric Compounds; D005296:Ferrous Compounds; D008024:Ligands; D007501:Iron; D008084:Lipoxygenase