title: Marfan syndrome in a Triple-X girl: a new association?
abstract: BACKGROUND
  Triple X is a sex chromosomal abnormality that involves the presence of three sex chromosomes resulting in 47, XXX karyotype. Most patients suffering from this syndrome are usually mentally normal or subnormal with no gross malformation.
  
  
  OBJECTIVE
  to report an unusual association between Triple X and Marfan disease in a girl.
  
  
  METHODS
  A case of a triple X girl with craniofacial dysmorphy and skeletal anomalies, who did feat Marfan criteria by age, is presented.
  
  
  CONCLUSIONS
  To the best of our knowledge this association has never been reported. Some clinical features are common between Triple X and Marfan disease so a careful follow-up is needed and investigations should be performed in these patients because Marfan syndrome may be incomplete in early age.
authors.affiliation: Department of Pediatrics B, Children's Hospital of Tunis.
authors.forename: Faten
authors.initials: F
authors.lastname: Tinsa
authors.forename: Lotfi
authors.initials: L
authors.lastname: Karboul
authors.forename: Jalel
authors.initials: J
authors.lastname: Chekib
authors.forename: Samia
authors.initials: S
authors.lastname: Hamouda
authors.forename: Lamia
authors.initials: L
authors.lastname: Ben Jemaa
authors.forename: Khadija
authors.initials: K
authors.lastname: Boussetta
authors.forename: Souad
authors.initials: S
authors.lastname: Bousnina
mesh_terms: D000015:Abnormalities, Multiple; D001284:Atrophy / Q000000981:diagnostic imaging; D001921:Brain / Q000473:pathology; D041321:Chromosomes, Human, X / Q000235:genetics*; D003241:Consanguinity; D005260:Female; D006801:Humans; D007223:Infant; D008382:Marfan Syndrome / Q000235:genetics*; D011859:Radiography; D012729:Sex Chromosome Aberrations