AVE 0991-angiotensin-(1-7) receptor agonist, inhibits atherogenesis in apoE-knockout mice.
Recent evidence shows that the renin-angiotensin system is a crucial player in atherosclerotic processes. It was also proved that Ang II promotes atherogenesis. Angiotensin-(1-7) [Ang-(1-7)] opposites Ang II action. Therefore, we would like to find out whether Ang-(1-7) receptor agonist: AVE 0991, could ameliorate atherosclerosis progression in an experimental model of atherosclerosis: apolipoprotein E (apoE) - knockout mice. AVE 0991 inhibited atherogenesis, measured both by "en face" method (7.63+/-1.6% vs. 14.6+/-2.1%) and "cross-section" method (47 235+/-7 546 microm(2) vs. 91 416+/-8 357 microm(2)). This is the first report showing the effect of AVE 0991 on atherogenesis in gene-targeted mice.
Toton-Zuranska
J
J
Chair of Pharmacology, Jagiellonian University Medical College, Cracow, Poland.
Gajda
M
M
Pyka-Fosciak
G
G
Kus
K
K
Pawlowska
M
M
Niepsuj
A
A
Wolkow
P
P
Olszanecki
R
R
Jawien
J
J
Korbut
R
R
D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics*; D050197:Atherosclerosis / Q000503:physiopathology / Q000517:prevention & control*; D004195:Disease Models, Animal; D018450:Disease Progression; D005260:Female; D007093:Imidazoles / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000819:agonists*; D043562:Receptors, G-Protein-Coupled / Q000819:agonists*
C469726:AVE 0991; D001057:Apolipoproteins E; D007093:Imidazoles; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D043562:Receptors, G-Protein-Coupled