Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum.
Pellitorine (1), which was isolated from the roots of Piper nigrum, showed strong cytotoxic activities against HL60 and MCT-7 cell lines. Microbial transformation of piperine (2) gave a new compound 5-[3,4-(methylenedioxy)phenyl]-pent-2-ene piperidine (3). Two other alkaloids were also found from Piper nigrum. They are (E)-1-[3',4'-(methylenedioxy)cinnamoyl]piperidine (4) and 2,4-tetradecadienoic acid isobutyl amide (5). These compounds were isolated using chromatographic methods and their structures were elucidated using MS, IR and NMR techniques.
Ee
Gwendoline Cheng Lian
GC
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Selangor, Malaysia. gwen@science.upm.edu.my
Lim
Chyi Meei
CM
Rahmani
Mawardi
M
Shaari
Khozirah
K
Bong
Choon Fah Joseph
CF
D000470:Alkaloids / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D052117:Benzodioxoles / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D029222:Piper nigrum / Q000737:chemistry*; D010880:Piperidines / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism* / Q000494:pharmacology*
C551082:5-(3,4-(methylenedioxy)phenyl)-pent-2-ene piperidine; D000470:Alkaloids; D000970:Antineoplastic Agents; D052117:Benzodioxoles; D005231:Fatty Acids, Unsaturated; D010880:Piperidines; D053284:Polyunsaturated Alkamides; C008778:pellitorine; C008922:piperine