title: Modulation of sweet taste sensitivity by orexigenic and anorexigenic factors.
abstract: The present study summarized recent findings on roles of leptin and endocannabinoids as modulators of the peripheral components of sweet taste. The positive effect of endocannabinoids on sweet sensitivity was opposed to that of leptin which suppresses sweet sensitivity. Leptin and endocannabinoids, therefore, not only regulate food intake via central nervous systems but also may modulate palatability of foods by altering peripheral sweet taste responses via their cognate receptors. Orexigenic and anorexigenic factors such as endocannnabinoids and leptin may affect energy homeostasis by regulating taste sensitivity.
authors.affiliation: Section of Oral Neuroscience, Kyushu University, Graduate School of Dental Sciences, Fukuoka, Japan.
authors.forename: Masafumi
authors.initials: M
authors.lastname: Jyotaki
authors.forename: Noriatsu
authors.initials: N
authors.lastname: Shigemura
authors.forename: Yuzo
authors.initials: Y
authors.lastname: Ninomiya
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D063385:Cannabinoid Receptor Modulators / Q000494:pharmacology*; D002241:Carbohydrates / Q000494:pharmacology; D002940:Circadian Rhythm; D004435:Eating / Q000502:physiology; D063388:Endocannabinoids; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology*; D005989:Glycerides / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood / Q000494:pharmacology*; D051379:Mice; D043884:Receptor, Cannabinoid, CB1 / Q000096:biosynthesis; D043562:Receptors, G-Protein-Coupled / Q000502:physiology; D013395:Sucrose / Q000494:pharmacology; D013649:Taste / Q000187:drug effects* / Q000502:physiology*; D013650:Taste Buds / Q000187:drug effects / Q000502:physiology
chemical_list: D001095:Arachidonic Acids; D063385:Cannabinoid Receptor Modulators; D002241:Carbohydrates; D063388:Endocannabinoids; D005989:Glycerides; D007328:Insulin; D020738:Leptin; D043884:Receptor, Cannabinoid, CB1; D043562:Receptors, G-Protein-Coupled; D013395:Sucrose; C094503:glyceryl 2-arachidonate