Ex post glycoconjugation of phthalocyanines.
For the first time, fully fledged phthalocyanines (Pcs) were ex post glycoconjugated, that is, via 1,3-dipolar cycloaddition reaction. This divergent approach gains rapid access to a broad range of highly diverse Pcs bearing chemically sensitive substituents. This will be a breakthrough in generating structure-activity relationships (SAR) for the development of novel bioactive molecules.
Berthold
Herwig J
HJ
Department of Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany.
Franke
Stephan
S
Thiem
Joachim
J
Schotten
Theo
T
D006031:Glycosylation; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D011838:Radiation-Sensitizing Agents; D013329:Structure-Activity Relationship
D007211:Indoles; D054833:Isoindoles; D011838:Radiation-Sensitizing Agents; C013647:phthalocyanine