[Preparation of paclitaxel-loaded polybutylcyanoacrylate nanoparticles].
OBJECTIVE
To evaluate the effect of different preparation methods on the encapsulation efficiency (EE) and drug loading (DL) of paclitaxel-loaded polybutylcyanoacrylate nanoparticles (PTX-PBCA-NPs) and optimize the preparation of PTX-PBCA-NPs.


METHODS
With DL and EE as the major indexes, the qualities of PTX-PBCA-NPs produced by the interfacial polymerization and emulsion polymerization method were compared. The optimized prescription was obtained by orthogonal design.


RESULTS
The ranges of EE of PTX-PBCA-NPs with the two methods were both 94.39%-99.23%. The highest DL with interfacial polymerization was (1.07-/+0.03)%, as compared to (0.86-/+0.01)% with emulsion polymerization. The optimized preparation conditions resulted in the mean size of PTX-PBCA-NPs of 235.6 nm, DL of 0.80%, and EE of 95.71%.


CONCLUSIONS
The EE of PTX-PBCA-NPs prepared by the above two methods is consistent with the requirement of the Pharmacopoeia of China, and PTX-PBCA-NPs containing higher DL can be obtained via interfacial polymerization.
Chen
Ru-da
RD
Department of Pharmacy, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. chenruda123@163.com
Ren
Fei
F
Li
Guo-feng
GF
Liu
Si-jia
SJ
D003692:Delayed-Action Preparations / Q000138:chemical synthesis*; D004337:Drug Carriers / Q000737:chemistry*; D016503:Drug Delivery Systems; D004659:Enbucrilate / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D017239:Paclitaxel / Q000008:administration & dosage*; D058105:Polymerization
D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004659:Enbucrilate; D017239:Paclitaxel