title: Single nucleotide polymorphisms of CD244 gene predispose to renal and neuropsychiatric manifestations with systemic lupus erythematosus.
abstract: The objective of this study was to explore the association of single nucleotide polymorphisms (SNPs) of the CD244 gene with several clinical features of systemic lupus erythematosus (SLE). Two hundred and forty-three patients with SLE and 369 healthy controls were enrolled. Two SNPs (rs6682654 and rs3766379) in the CD244 gene were determined by allelic discrimination using a specific TaqMan probe. Only SNP rs3766379 was significantly associated with susceptibility to SLE [P = 0.009; odds ratio (OR) 1.28; 95% confidence interval (CI) 1.04-1.57]. The association was preferentially observed in subsets of SLE patients with nephritis and neuropsychiatric lupus. The frequency of the rs6682654 C allele was strongly associated with nephritis and neuropsychiatric lupus (P = 0.00065; OR 1.99; 95% CI 1.34-2.95, and P = 1.6 × 10(-7); OR 3.47; 95% CI 2.12-5.70, respectively), as was the frequency of the rs3766379 T allele (P = 0.0014; OR 1.86; 95% CI 1.27-2.71, and P = 2.6 × 10(-7); OR 3.15; 95% CI 2.00-4.96, respectively). In this study, an SNP of the CD244 gene was associated with susceptibility to SLE. There was a strikingly strong association in SLE patients with nephritis and neuropsychiatric lupus, suggesting that this genetic marker could predict involvement of those severe complications.
authors.affiliation: Institute of Rheumatology, Tokyo Women's Medical University, 10-22 Kawada-cho, Shinjuku-ku, Tokyo 162-0054, Japan.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ota
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kawaguchi
authors.forename: Kae
authors.initials: K
authors.lastname: Takagi
authors.forename: Akiko
authors.initials: A
authors.lastname: Tochimoto
authors.forename: Manabu
authors.initials: M
authors.lastname: Kawamoto
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Katsumata
authors.forename: Takahisa
authors.initials: T
authors.lastname: Gono
authors.forename: Ikuko
authors.initials: I
authors.lastname: Masuda
authors.forename: Katsunori
authors.initials: K
authors.lastname: Ikari
authors.forename: Shigeki
authors.initials: S
authors.lastname: Momohara
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamanaka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D008181:Lupus Nephritis / Q000235:genetics* / Q000473:pathology; D020945:Lupus Vasculitis, Central Nervous System / Q000235:genetics* / Q000473:pathology / Q000523:psychology; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011971:Receptors, Immunologic / Q000235:genetics*; D000071176:Signaling Lymphocytic Activation Molecule Family; D055815:Young Adult
chemical_list: D015703:Antigens, CD; C084093:CD244 protein, human; D005819:Genetic Markers; D011971:Receptors, Immunologic; D000071176:Signaling Lymphocytic Activation Molecule Family