title: The direct catalytic asymmetric aldol reaction.
abstract: Asymmetric aldol reactions are a powerful method for the construction of carbon-carbon bonds in an enantioselective fashion. Historically this reaction has been performed in a stoichiometric fashion to control the various aspects of chemo-, diastereo-, regio- and enantioselectivity, however, a more atom economical approach would unite high selectivity with the use of only a catalytic amount of a chiral promoter. This critical review documents the development of direct catalytic asymmetric aldol methodologies, including organocatalytic and metal-based strategies. New methods have improved the reactivity, selectivity and substrate scope of the direct aldol reaction and enabled the synthesis of complex molecular targets (357 references).
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA 94305-5080, USA. bmtrost@stanford.edu
authors.forename: Barry M
authors.initials: BM
authors.lastname: Trost
authors.forename: Cheyenne S
authors.initials: CS
authors.lastname: Brindle
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D007659:Ketones; D008670:Metals