Evaluating the porcine dermis graft InteXen in three-compartment transvaginal pelvic organ prolapse repair.
OBJECTIVE
The aim was to assess the efficacy of three-compartment pelvic organ prolapse (POP) vaginal repair using the InteXen biocompatible porcine dermal graft as compared to traditional colporrhaphy with sacrospinous ligament suspension.


METHODS
Preoperative, operative, postoperative and follow-up data were collected retrospectively. Objective recurrence was defined as POP quantification >or= stage II and subjective recurrence as a symptomatic bulge.


RESULTS
Each group consisted of 63 patients. Surgery time was longer using InteXen (72 +/- 24.5 vs 55 +/- 23.5 min, p = 0.0002). Length of hospital stay (4.6 +/- 1.6 vs 4.9 +/- 2.1 days, p = 0.34) as well as duration of follow-up (37.1 vs 35.7 months, p = 0.45) were equivalent between the two groups. No case of mesh erosion or infection was noted. The objective (17% vs 8%, p = 0.12) and subjective recurrence rates (13% vs 5%, p = 0.12) between the two groups were not statistically different.


CONCLUSIONS
InteXen was well tolerated but had similar efficacy to traditional colporrhaphy and sacrospinous ligament suspension.
Ramanah
Rajeev
R
Department of Gynecologic Surgery, Besancon University Medical Centre, 8 Mai 1945 Avenue, 25000, Besancon, France. rajeev2074@yahoo.fr
Mairot
Julian
J
Clement
Marie-Caroline
MC
Parratte
Bernard
B
Maillet
Robert
R
Riethmuller
Didier
D
D001705:Bioprosthesis; D020405:Dermis / Q000637:transplantation*; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000379:methods*; D006801:Humans; D008875:Middle Aged; D056887:Pelvic Organ Prolapse / Q000601:surgery*; D011474:Prosthesis Design; D012008:Recurrence; D016896:Treatment Outcome; D014621:Vagina / Q000601:surgery*