title: Efficacy of a methylphenidate transdermal system versus t.i.d. methylphenidate in a laboratory setting.
abstract: OBJECTIVE
  To test the efficacy and tolerability of the methylphenidate transdermal formulation (MTS) against immediate-release methylphenidate (IR MPH) and placebo in a 12-hr analog classroom setting.
  
  
  METHODS
  A total of nine boys ages 6 to 9 years, medicated with MPH for ADHD, complete a within-subject, double-blind study. For the purpose of the study, the boys are administered a dose of 20 cm(2) MTS, a matched dose of IR MPH 10 mg TID, and placebo. ADHD symptoms and frequency counts of classroom rule violations and the number of math problems completed are assessed hourly, during three consecutive analog classroom sessions.
  
  
  RESULTS
  Findings show that, across measures and throughout the day, both treatments significantly differentiated from placebo (p < .05) but not from each other. It is also observed that the MTS produced more consistent results across the day but had a delayed onset versus IR MPH. Both medications are well tolerated with only mild reductions in sleep onset.
  
  
  CONCLUSIONS
  The MTS demonstrates comparable efficacy and tolerability to TID IR MPH.
authors.affiliation: State University of New York, USA. pelham@buffalo.edu
authors.forename: William E
authors.initials: WE
authors.lastname: Pelham
authors.forename: James G
authors.initials: JG
authors.lastname: Waxmonsky
authors.forename: Jerome
authors.initials: J
authors.lastname: Schentag
authors.forename: Charles H
authors.initials: CH
authors.lastname: Ballow
authors.forename: Carlos J
authors.initials: CJ
authors.lastname: Panahon
authors.forename: Elizabeth M
authors.initials: EM
authors.lastname: Gnagy
authors.forename: Martin T
authors.initials: MT
authors.lastname: Hoffman
authors.forename: Lisa
authors.initials: L
authors.lastname: Burrows-MacLean
authors.forename: David L
authors.initials: DL
authors.lastname: Meichenbaum
authors.forename: Gregory L
authors.initials: GL
authors.lastname: Forehand
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Fabiano
authors.forename: Katy E
authors.initials: KE
authors.lastname: Tresco
authors.forename: Andy
authors.initials: A
authors.lastname: Lopez-Williams
authors.forename: Erika K
authors.initials: EK
authors.lastname: Coles
authors.forename: Mario A
authors.initials: MA
authors.lastname: González
mesh_terms: D000279:Administration, Cutaneous; D000704:Analysis of Variance; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D000697:Central Nervous System Stimulants / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000008:administration & dosage* / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate