New treatments for gout.
Gout is a commonly occurring medical condition that can lead to significant morbidity. Therapies available for the treatment of both acute and chronic gouty arthritis have not changed significantly since the 1960s. Although these treatments are well established, they are often contraindicated in the presence of various different comorbidities, including diabetes, renal insufficiency, hypertension and gastrointestinal disease, all of which can occur frequently in patients with gout. Therefore, new treatments are needed. This review describes recent advances in therapeutics for gout, including drugs designed to reduce levels of urate and to inhibit acute or chronic inflammation. While some of these strategies are currently available, others are undergoing regulatory evaluation or are at earlier stages of development.
Mapa
Janet B
JB
NYU Hospital for Joint Diseases, Division of Rheumatology, 301 East 17th Street, Room 1410, New York, NY 10003, USA.
Pillinger
Michael H
MH
D000818:Animals; D015210:Arthritis, Gouty / Q000150:complications / Q000188:drug therapy / Q000276:immunology; D002986:Clinical Trials as Topic; D015195:Drug Design; D006073:Gout / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D006074:Gout Suppressants / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D016896:Treatment Outcome
D006074:Gout Suppressants