title: An exploratory pilot study into the association between microcirculatory parameters derived by MRI-based pharmacokinetic analysis and glucose utilization estimated by PET-CT imaging in head and neck cancer.
abstract: OBJECTIVE
  To examine the feasibility of deriving quantitative microcirculatory parameters and to investigate the relationship between vascular and metabolic characteristics of head and neck tumours in vivo, using dynamic contrast-enhanced (DCE) MRI and fluorodeoxyglucose (FDG) PET imaging.
  
  
  METHODS
  Twenty-seven patients with primary squamous cell carcinoma (SCCA) underwent DCE-MRI and combined PET/CT imaging. DCE-MRI data were post-processed by using commercially available software. Transfer constant (K (trans)), extravascular extracellular blood volume (v (e)), transfer constant from the extracellular extravascular space to plasma (k (ep)) and iAUC (initial area under the signal intensity-time curve) were calculated. 3D static PET data were acquired and standardised uptake values (SUV) calculated.
  
  
  RESULTS
  All microcirculatory parameters in tumours were higher than in normal muscle tissue (P ≤ 0.0019). Significant correlations were shown between k (ep) and K (trans) (ρ = 0.77), v (e) and k (ep) (ρ = -0.7), and iAUC and v (e) (ρ = 0.53). Significant correlations were observed for SUV(mean) and v (e) as well as iAUC (ρ = 0.42 and ρ = 0.66, respectively). SUV(max) was significantly correlated with iAUC (ρ = 0.69).
  
  
  CONCLUSIONS
  The demonstrated relationships between vascular and metabolic characteristics of primary SCCA imply a complex interaction between vascular delivery characteristics and tumour metabolism. The lack of correlation between SUV and K (trans)/k (ep) suggests that both diagnostic techniques may provide complementary information.
authors.affiliation: Department of Neuroradiology, Eberhard Karls University Hospital, Hoppe Seyler Str. 3, 72076, Tübingen, Germany. Sotirios.Bisdas@med.uni-tuebingen.de
authors.forename: Sotirios
authors.initials: S
authors.lastname: Bisdas
authors.forename: Oliver
authors.initials: O
authors.lastname: Seitz
authors.forename: Markus
authors.initials: M
authors.lastname: Middendorp
authors.forename: Nicole
authors.initials: N
authors.lastname: Chambron-Pinho
authors.forename: Theodosios
authors.initials: T
authors.lastname: Bisdas
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Vogl
authors.forename: Renate
authors.initials: R
authors.lastname: Hammerstingl
authors.forename: Ulrike
authors.initials: U
authors.lastname: Ernemann
authors.forename: Martin G
authors.initials: MG
authors.lastname: Mack
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000494:pharmacology; D005947:Glucose / Q000493:pharmacokinetics*; D006258:Head and Neck Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D006801:Humans; D007700:Kinetics; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D010865:Pilot Projects; D049268:Positron-Emission Tomography / Q000379:methods*; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D019788:Fluorodeoxyglucose F18; D005947:Glucose