title: [Analysis of the risk factors for hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation for beta-thalassemia in children].
abstract: OBJECTIVE
  To analyze the risk factors of hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation for beta-thalassemia in children.
  
  
  METHODS
  The clinical records of 30 children with beta-thalassemia undergoing allogeneic hematopoietic stem cell transplantation between December, 2008 and November, 2009 were analyzed.
  
  
  RESULTS
  Hemorrhagic cystitis occurred in 8 of the 33 patients with an incidence of 24.24%, including 1 with grade I, 6 with grade II and 1 with grade III hemorrhagic cystitis. The median time of hemorrhagic cystitis onset was 22.9 days (range 6-35 days) and the median duration was 11.9 days(range 3-27 days). Univariate analysis indicated that the different types of transplantation and acute graft-versus-host disease affect the occurrence of hemorrhagic cystitis. The children with Allo-PBSCT had higher incidence than those receiving Allo-PBSCT+Allo-UBT and Allo-BMT (P<0.05). The children at an age >or=6 years had obviously higher incidence of hemorrhagic cystitis than those at younger ages.
  
  
  CONCLUSIONS
  Age is the major factor that affects the occurrence of hemorrhagic cystitis in children undergoing allogeneic hematopoietic stem cell transplantation for beta-thalassemia.
authors.affiliation: Department of Pediatrics, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
authors.forename: Wen-fang
authors.initials: WF
authors.lastname: Yin
authors.forename: Fu-yu
authors.initials: FY
authors.lastname: Pei
authors.forename: Xue-dong
authors.initials: XD
authors.lastname: Wu
authors.forename: Si-xi
authors.initials: SX
authors.lastname: Liu
authors.forename: Yue-lin
authors.initials: YL
authors.lastname: He
authors.forename: Jian-yun
authors.initials: JY
authors.lastname: Liao
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Ge-yu
authors.initials: GY
authors.lastname: Chen
authors.forename: Xiao-qing
authors.initials: XQ
authors.lastname: Feng
authors.forename: Chun-fu
authors.initials: CF
authors.lastname: Li
mesh_terms: D000367:Age Factors; D002648:Child; D002681:China / Q000453:epidemiology; D003556:Cystitis / Q000453:epidemiology / Q000209:etiology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D012307:Risk Factors; D014184:Transplantation, Homologous; D017086:beta-Thalassemia / Q000628:therapy*