SNPs of Fc-gamma receptor genes and chronic periodontitis.
Genetic polymorphisms of host defense genes might increase risk for periodontitis. This case-control study investigated whether 102 single-nucleotide polymorphisms (SNPs) in Fc gamma receptor (FCGR) genes are associated with chronic periodontitis. Cases were 190 Hong Kong Chinese patients with severe chronic periodontitis, and there were 169 periodontitis-free individuals as controls. Genotype CC and allele C of rs445509 (p < 0.0001, OR = 0.30) of FCGR3A were significantly more prevalent among control individuals than among cases, after adjustment for age, sex, and smoking. Smoking was significantly associated with chronic periodontitis (p = 0.003, OR = 3.35). Within the limitations of this study, SNP rs445509 of FCGR3A seem to be negatively associated, while smoking was positively associated, with severe chronic periodontitis among Hong Kong Chinese.
Chai
L
L
Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Hong Kong SAR, China.
Song
Y-Q
YQ
Zee
K-Y
KY
Leung
W K
WK
D000225:Adenine; D000328:Adult; D000367:Age Factors; D000483:Alleles; D016022:Case-Control Studies; D055113:Chronic Periodontitis / Q000235:genetics*; D003596:Cytosine; D005260:Female; D005838:Genotype; D006147:Guanine; D006239:Haplotypes; D006723:Hong Kong; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics*; D012737:Sex Factors; D012907:Smoking; D013941:Thymine
C445323:FCGR2A protein, human; C499173:FCGR2B protein, human; C496124:FCGR3A protein, human; D017452:Receptors, IgG; D006147:Guanine; D003596:Cytosine; D000225:Adenine; D013941:Thymine