Long-term survival after surgery for stage III-IV maxillary sinus carcinoma.
OBJECTIVE
How to optimally treat maxillary sinus carcinoma is subject to debate. This study assessed how clinical features and treatment modalities corresponded with long-term survival.


METHODS
Sixty-five patients at our institution were diagnosed with maxillary sinus carcinoma from 1982 to 2003. The median follow-up time was 92.9 months. We evaluated the prognostic value of age, gender, symptoms at presentation, histological classification, tumour stage, and treatment modality with regard to overall survival.


RESULTS
The five-year survival rate was 52%. Age (p = 0.03), TNM stage (p = 0.04), T classification (p = 0.04), nodal involvement (p = 0.03), and surgery (p = 0.04) were significant prognostic factors for overall survival. There was a significant difference in the overall survival rate and months of survival between patients who underwent surgery and those who had nonsurgical treatment (p = 0.04). In patients with T3 disease, patients who received en bloc surgery had a higher overall survival than patients who received piecemeal surgery (p = 0.045). Multivariate analysis revealed that T classification was the most powerful prognostic factor for overall survival (p = 0.026), followed by nodal involvement (p = 0.036). Surgery was a marginally significant prognostic factor (p = 0.066).


CONCLUSIONS
Although multivariate analysis showed that T classification and nodal involvement corresponded more with survival than did surgery, we conclude that adequate surgical removal should be an integral component of multimodal treatment.
Wu
T-H
TH
Division of Hemato-oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Keelung & Chang Gung University, College of Medicine, Keelung, Taiwan.
Huang
J-S
JS
Wang
H-M
HM
Chang
J W-C
JW
Song
G-G
GG
Wang
C-H
CH
Yeh
K-Y
KY
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D011379:Prognosis