title: The impact of CCL3L1 copy number in an HIV-1-infected white population.
abstract: We examined the effect of CCL3L1 gene copy number on disease progression in a North American white cohort of HIV-1-infected individuals. Although CCL3L1 copy number is enriched in uninfected Caucasians, in HIV-1-infected individuals CCL3L1 copy number did not correlate either with long-term nonprogression or with CD4 cell count or viral load in chronic progressors. These findings underscore the heterogeneity of factors involved with long-term nonprogression when comparing cohorts of varying ethnic backgrounds.
authors.affiliation: Department of Immunology, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Erika Y
authors.initials: EY
authors.lastname: Lee
authors.forename: Feng Y
authors.initials: FY
authors.lastname: Yue
authors.forename: Richard B
authors.initials: RB
authors.lastname: Jones
authors.forename: Calvin
authors.initials: C
authors.lastname: Lo
authors.forename: Prameet
authors.initials: P
authors.lastname: Sheth
authors.forename: Martin D
authors.initials: MD
authors.lastname: Hyrcza
authors.forename: Colin
authors.initials: C
authors.lastname: Kovacs
authors.forename: Erika
authors.initials: E
authors.lastname: Benko
authors.forename: Rupert
authors.initials: R
authors.lastname: Kaul
authors.forename: Mario
authors.initials: M
authors.lastname: Ostrowski
mesh_terms: D018791:CD4 Lymphocyte Count; D019742:Chemokines, CC / Q000235:genetics*; D018450:Disease Progression; D018628:Gene Dosage; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D019562:Viral Load; D044465:White People / Q000235:genetics*
chemical_list: C492767:CCL3L1 protein, human; D019742:Chemokines, CC