title: Efficient, mild and completely regioselective synthesis of substituted pyridines.
abstract: Addition of Grignard reagents to pyridine N-oxides in THF at low temperature (-78 to -20 degrees C) and treatment with TFAA provides an efficient general procedure for synthesis of substituted pyridines. The method is compatible with a range of functional groups such as esters, halogens and nitriles.
authors.affiliation: Department of Chemistry, Umeå University, SE-90187 Umeå, Sweden.
authors.forename: Hans
authors.initials: H
authors.lastname: Andersson
authors.forename: Thomas Sainte-Luce
authors.initials: TS
authors.lastname: Banchelin
authors.forename: Sajal
authors.initials: S
authors.lastname: Das
authors.forename: Roger
authors.initials: R
authors.lastname: Olsson
authors.forename: Fredrik
authors.initials: F
authors.lastname: Almqvist
mesh_terms: D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D009942:Organometallic Compounds; D011725:Pyridines