title: High dose-rate endobronchial radiotherapy for proximal airway obstruction due to lung cancer: 8-year experience of a referral center.
abstract: The efficacy of high dose-rate endobronchial radiotherapy (HDERT) against proximal airway obstruction that results from lung cancer has not been thoroughly evaluated. This study retrospectively reviewed tumor/obstruction characteristics prior to therapy, interventions applied, symptoms before and after intervention, complications, and survival of all patients with proximal airway obstruction resulting from lung cancer who received HDERT between 1995 and 2003 in a tertiary teaching center. Thirty-four (34) patients received HDERT, while 28 had additional treatment (external radiotherapy = 23, neodymium yttrium aluminum garnet laser ablation = 9, stenting = 7, electrosurgery = 5, cryosurgery = 3, and photodynamic therapy = 1). Sixteen (16) patients developed complications, the most frequent being respiratory failure and bronchial-wall necrosis, while 19 experienced symptomatic relief. The median (95% confidence interval) survival of these 34 patients was 7.8 (5.9-9.8) months, significantly longer (p = 0.004) than a historic control of 3.9 (3.7-7.1) months from the Cleveland Clinic Foundation, in Cleveland, OH, and comparable to other previous reports. No single factor predicted complications or symptomatic relief. However, female gender, presence of only one symptom, absence of fatigue/weight loss, >1 HDERT sessions, and postprocedure symptom relief were associated with improved survival. Contemporary HDERT with or without additional treatment modalities is effective against central airway compromise resulting from lung cancer.
authors.affiliation: Department of Pulmonary, Allergy and Critical Care Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio, USA. fmanali@otenet.gr
authors.forename: Effrosyni D
authors.initials: ED
authors.lastname: Manali
authors.forename: Georgios T
authors.initials: GT
authors.lastname: Stathopoulos
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Gildea
authors.forename: Peter
authors.initials: P
authors.lastname: Fleming
authors.forename: Julie
authors.initials: J
authors.lastname: Thornton
authors.forename: Meng
authors.initials: M
authors.lastname: Xu
authors.forename: Spyros A
authors.initials: SA
authors.lastname: Papiris
authors.forename: Atul C
authors.initials: AC
authors.lastname: Mehta
authors.forename: Majid M
authors.initials: MM
authors.lastname: Mughal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000402:Airway Obstruction / Q000209:etiology / Q000532:radiotherapy*; D001918:Brachytherapy; D002283:Carcinoma, Bronchogenic / Q000532:radiotherapy*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D011379:Prognosis; D011879:Radiotherapy Dosage; D012017:Referral and Consultation; D012189:Retrospective Studies; D015996:Survival Rate