Gel-sol-gel thermo-gelation behavior study of chitosan-inorganic phosphate solutions.
In present study, the feasibility of developing a novel thermo-sensitive hydrogel suitable for injectable formulations based on chitosan and inorganic phosphate was demonstrated. The physicochemical and rheological changes of chitosan/dibasic sodium phosphate solutions as in function with temperature were investigated in order to gain a better understanding of gelation process. According to the result of rheological study, there are two phase transition points as in function with temperature, corresponding to 30 degrees C and 43 degrees C. The system is gel state at approximately 4 degrees C. With the temperature increased to 30 degrees C, the gel-sol transition as well as the decrease in turbidity was observed. The sol-gel transition as well as the increase in turbidity was observed again as the temperature was above 43 degrees C. And the gel obtained at approximately 4 degrees C is reversible, but the gel obtained at approximately 43 degrees C is irreversible.
Li
XingYi
X
State Key Laboratory of Biotherapy and Cancer Center, Sichuan University, Chengdu, China.
Kong
XiangYe
X
Wang
XiuHong
X
Shi
Shuai
S
Guo
Gang
G
Luo
Feng
F
Zhao
Xia
X
Wei
YuQuan
Y
Qian
ZhiYong
Z
D048271:Chitosan / Q000737:chemistry*; D020100:Hydrogels; D006863:Hydrogen-Ion Concentration; D009391:Nephelometry and Turbidimetry; D009994:Osmolar Concentration; D010710:Phosphates / Q000737:chemistry*; D012212:Rheology; D012996:Solutions; D013696:Temperature
D020100:Hydrogels; D010710:Phosphates; D012996:Solutions; D048271:Chitosan