title: Stereotactic body radiation therapy for spinal metastases.
abstract: Stereotactic body radiation therapy (SBRT) has emerged as a novel treatment modality for spinal metastases. Due to advances in radiation delivery technologies, it is now possible to deliver ablative doses to spinal metastases safely and effectively, and in particular high-dose re-irradiation. Data from the literature has demonstrated high rates of pain and local control with SBRT for spinal metastases, which is an active area of clinical investigation. Although there are potential therapeutic gains with spine SBRT, toxicities rarely seen with conventional radiotherapy, such as radiation-induced myelopathy and vertebral fractures, have been observed after SBRT in a small percentage of patients. Prospective clinical trials are required to define the role of SBRT in the management of spinal metastasis and to determine the appropriateness of using SBRT in various clinical settings. The purpose of this review is to provide an overview of the current state of spine SBRT practice.
authors.affiliation: Department of Radiation Oncology, Arthur G. James Cancer Hospital, Ohio State University, Columbus, Ohio 43210, USA. Simon.Lo@osumc.edu
authors.forename: Simon S
authors.initials: SS
authors.lastname: Lo
authors.forename: Arjun
authors.initials: A
authors.lastname: Sahgal
authors.forename: Jian Z
authors.initials: JZ
authors.lastname: Wang
authors.forename: Nina A
authors.initials: NA
authors.lastname: Mayr
authors.forename: Andrew
authors.initials: A
authors.lastname: Sloan
authors.forename: Ehud
authors.initials: E
authors.lastname: Mendel
authors.forename: Eric L
authors.initials: EL
authors.lastname: Chang
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D018579:Patient Selection; D011859:Radiography; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000532:radiotherapy* / Q000556:secondary*; D013238:Stereotaxic Techniques; D014916:Whole-Body Irradiation / Q000009:adverse effects / Q000379:methods*