title: Clinical and electronystagmographical evaluation of vestibular symptoms in relapsing remitting multiple sclerosis.
abstract: OBJECTIVE
  Multiple sclerosis (MS) may give rise to a variety of clinical signs and symptoms including vertigo and/or other problems related with equilibrium. In this study, we aimed to evaluate clinical and electronystagmographical (ENG) characteristics of relapsing remitting MS (RRMS) patients.
  
  
  METHODS
  This is a prospective controlled study consisting of 30 patients who were diagnosed as definite RRMS according to McDonald's diagnostic criteria and 30 healthy individuals.
  
  
  METHODS
  Entire population of patients were examined and followed up at the same tertiary centre during the period of September 2003 and March 2005. Clinical examination and detailed electronystagmographic investigations were performed in each group.
  
  
  METHODS
  Vestibular laboratory testing was carried out by a computerized ENG system. All ENG subtests including tracking, saccade, optokinetic, gaze, positional and Dix-Hallpike tests were performed in each group but caloric, which is relatively an invasive test, was performed only in the patient group.
  
  
  METHODS
  We aimed to find the ratio of abnormal tests indicating, central and/or peripheral pathology in ENG. We also analyzed the correlation of total number of abnormal tests in ENG with clinical parameters.
  
  
  RESULTS
  Differences of ENG abnormality indicating central and/or peripheral pathology and ENG abnormality indicating only central pathology between the two groups were statistically significant. Correlation of total number of abnormal tests in ENG with EDSS score was statistically significant.
  
  
  CONCLUSIONS
  ENG is sensitive in detecting the vestibular system involvement in RRMS patients if all subtests are performed and evaluated in detail with clinical symptoms and signs.
authors.affiliation: Neurology Department, Medical Faculty, Pamukkale University, Denizli, Turkey. eylemteke@yahoo.com
authors.forename: Eylem
authors.initials: E
authors.lastname: Degirmenci
authors.forename: Levent Sinan
authors.initials: LS
authors.lastname: Bir
authors.forename: Fazil Necdet
authors.initials: FN
authors.lastname: Ardic
mesh_terms: D000328:Adult; D003936:Diagnosis, Computer-Assisted / Q000379:methods; D004576:Electromyography / Q000379:methods*; D005133:Eye Movements / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000150:complications*; D017120:Nystagmus, Optokinetic / Q000502:physiology; D011446:Prospective Studies; D012189:Retrospective Studies; D012438:Saccades / Q000502:physiology; D018709:Statistics, Nonparametric; D015837:Vestibular Diseases / Q000175:diagnosis* / Q000209:etiology*; D055815:Young Adult