title: The role of excitatory amino acid transporters in cerebral ischemia.
abstract: Glutamate is an excitatory neurotransmitter that plays a major role in the pathogenesis of ischemia brain injury. The regulation of glutamate neurotransmission is carried out by excitatory amino acid transporters (EAATs) that act through reuptake of glutamate into cells. EAATs may also release glutamate into the extracellular space in a calcium-independent manner during ischemia and dysfunction of EAATs is specifically implicated in the pathology of cerebral ischemia. Recent studies show that up-regulation of EAAT2 provides neuroprotection during ischemic insult. This review summarizes current knowledge regarding the role of EAATs in cerebral ischemia.
authors.affiliation: Department of Neurosurgery, Xi Jing Hospital, Fourth Military Medical University, Xi'an, China. kelyue@msn.com
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Chao
authors.forename: Fei
authors.initials: F
authors.lastname: Fei
authors.forename: Zhou
authors.initials: Z
authors.lastname: Fei
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D005786:Gene Expression Regulation; D050491:Glutamate Plasma Membrane Transport Proteins / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans
chemical_list: D050491:Glutamate Plasma Membrane Transport Proteins