title: Percutaneous management of aortic stenosis in high-risk patients.
abstract: As the population ages, the prevalence of aortic stenosis is increasing. There is an unmet clinical need for the treatment of aortic stenosis in high-risk patients, who are often older, frail and have multiple comorbidities. Percutaneous aortic valve replacement (PAVR) is a new and innovative technique for the management of high-risk patients with aortic stenosis. There are currently two devices under evaluation in clinical trials in Australia: the CoreValve ReValving System and the Edwards SAPIEN valve. These devices are generally deployed retrogradely, mainly transfemorally or via the subclavian artery or, less commonly, transapically. Initial experience has been encouraging, with good short-term outcomes. However, there is a lack of long-term data. PAVR is presently only advocated for high-risk older patients with symptomatic aortic stenosis. Where PAVR lies in the treatment algorithm for aortic stenosis will be determined by randomised controlled trials, but for now it offers a genuine treatment alternative for high-risk patients.
authors.affiliation: Prince Charles Hospital, Brisbane, QLD, Australia. jamielayland@hotmail.com
authors.forename: Jamie J
authors.initials: JJ
authors.lastname: Layland
authors.forename: Brendan
authors.initials: B
authors.lastname: Bell
authors.forename: Dan
authors.initials: D
authors.lastname: Mullany
authors.forename: Darren L
authors.initials: DL
authors.lastname: Walters
mesh_terms: D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D001024:Aortic Valve Stenosis / Q000503:physiopathology / Q000601:surgery*; D002404:Catheterization / Q000379:methods; D015897:Comorbidity; D016330:Frail Elderly; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome