Nonsteroidal anti-inflammatory drugs in orthopaedics.
It is important for orthopaedic surgeons to understand the role of prostaglandins in bone physiology and the mechanism of action of nonsteroidal anti-inflammatory drugs and their role in fracture healing, fusion, osteointegration, and aseptic loosening. Nonsteroidal anti-inflammatory drugs have benefits and risks in orthopaedic use, and their effects should be considered.
Abdul-Hadi
Omar
O
Southern Oregon Orthopedics, Medford, Oregon, USA.
Parvizi
Javad
J
Austin
Matthew S
MS
Viscusi
Eugene R
ER
Einhorn
Thomas A
TA
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001842:Bone and Bones / Q000187:drug effects*; D005592:Fracture Fixation; D017102:Fracture Healing / Q000187:drug effects*; D006801:Humans; D016348:Osseointegration / Q000187:drug effects*; D011475:Prosthesis Failure; D013123:Spinal Fusion; D013710:Tendons / Q000187:drug effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal