title: One-generation reproductive toxicity study of epichlorohydrin in Sprague-Dawley rats.
abstract: This study was conducted to evaluate the potential reproductive toxicity of epichlorohydrin in a one-generation reproduction toxicity study in compliance with OECD Test Guideline 415. Twenty-four male and female rats per group were given epichlorohydrin by gavage at 0, 3.3, 10, and 30 mg/kg/day. Males were dosed for 10 weeks prior to and during mating. Females were dosed from 2 weeks before mating to day 21 of lactation. At 30 mg/kg, an increase in the incidence of clinical signs (i.e., nasal discharge, soft feces, depression, and piloerection), gross necropsy findings (i.e., cystic pustule of the epididymidis and enlargement of the kidney) and the weights of heart, liver, and epididymidis, a decrease in male fertility, and an increased incidence of histopathological changes of the testis, epididymidis, and kidney were observed. At 10 mg/kg, decreased male fertility and increased kidney weight and incidence of histopathological changes of the epididymidis were found. There was a slight, but nonsignificant, reduction in the male fertility index at the dose of 3.3 mg/ kg. Under these experimental conditions, the lowest-observed-adverse-effect level of epichlorohydrin was 3.3 mg/kg/day for parent animals and their offspring. The absolute toxic dose for parent animals and their offspring was estimated to be 10 mg/kg/day.
authors.affiliation: Animal Medical Center, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea.
authors.forename: In-Sik
authors.initials: IS
authors.lastname: Shin
authors.forename: Na-Hyeong
authors.initials: NH
authors.lastname: Park
authors.forename: Jong-Chan
authors.initials: JC
authors.lastname: Lee
authors.forename: Kang-Hyeon
authors.initials: KH
authors.lastname: Kim
authors.forename: Changjong
authors.initials: C
authors.lastname: Moon
authors.forename: Sung-Ho
authors.initials: SH
authors.lastname: Kim
authors.forename: Dong-Ho
authors.initials: DH
authors.lastname: Shin
authors.forename: Seung-Chun
authors.initials: SC
authors.lastname: Park
authors.forename: Hyeon-Young
authors.initials: HY
authors.lastname: Kim
authors.forename: Jong-Choon
authors.initials: JC
authors.lastname: Kim
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal; D001835:Body Weight; D004781:Environmental Exposure; D004811:Epichlorohydrin / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D006651:Histocytochemistry; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size; D011247:Pregnancy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects*
chemical_list: D004811:Epichlorohydrin