title: Acute immune-mediated thrombocytopenia due to oxaliplatin administration: a case report.
abstract: Drug-induced acute thrombocytopenia is an extremely rare side effect that may occur immediately after oxaliplatin infusion. This potentially fatal reaction is immune mediated and can be anticipated by mild hemorrhagic signs during previous administrations. This is the first report of acute thrombocytopenia occurring during adjuvant treatment of colorectal cancer with oxaliplatin. Clinicians should be aware of this adverse event in order to prevent possible serious consequences and stop further oxaliplatin administration.
authors.affiliation: Medical Oncology Unit 2, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.
authors.forename: Filippo
authors.initials: F
authors.lastname: Pietrantonio
authors.forename: Maria
authors.initials: M
authors.lastname: Di Bartolomeo
authors.forename: Roberto
authors.initials: R
authors.lastname: Buzzoni
authors.forename: Emilio
authors.initials: E
authors.lastname: Bajetta
mesh_terms: D000208:Acute Disease; D000230:Adenocarcinoma / Q000188:drug therapy* / Q000601:surgery; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D017024:Chemotherapy, Adjuvant / Q000009:adverse effects; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000601:surgery; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D000077150:Oxaliplatin; D017713:Platelet Transfusion; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology* / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D000077150:Oxaliplatin