Carbon nanotube transistor controlled by a biological ion pump gate.
We report a hybrid bionanoelectronic transistor that has a local ATP-powered protein gate. ATP-dependent activity of a membrane ion pump, Na(+)/K(+)-ATPase, embedded in a lipid membrane covering the carbon nanotube, modulates the transistor output current by up to 40%. The ion pump gates the device by shifting the pH of the water layer between the lipid bilayer and nanotube surface. This transistor is a versatile bionanoelectronic platform that can incorporate other membrane proteins.
Huang
Shih-Chieh J
SC
Molecular Biophysics and Functional Nanostructures Group, Physical and Life Sciences Directorate, Lawrence Livermore National Laboratory, Livermore, CA, USA.
Artyukhin
Alexander B
AB
Misra
Nipun
N
Martinez
Julio A
JA
Stroeve
Pieter A
PA
Grigoropoulos
Costas P
CP
Ju
Jiann-Wen W
JW
Noy
Aleksandr
A
D000255:Adenosine Triphosphate / Q000737:chemistry*; D040761:Biomimetic Materials; D004867:Equipment Design; D019544:Equipment Failure Analysis; D015640:Ion Channel Gating; D008051:Lipid Bilayers / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation*; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000648:ultrastructure; D010316:Particle Size; D012815:Signal Processing, Computer-Assisted; D000254:Sodium-Potassium-Exchanging ATPase / Q000737:chemistry*; D014173:Transistors, Electronic
D008051:Lipid Bilayers; D037742:Nanotubes, Carbon; D000255:Adenosine Triphosphate; D000254:Sodium-Potassium-Exchanging ATPase