title: [Proteasomes and their role in transcriptional regulation].
abstract: 26S proteasome is a multisubunit protein complex that plays a pivotal role in protein degradation. Proteasome's enzymatic activities--proteolytic, ATPase/helicase and RNase--can be used in regulation of multiple cellular processes. Recent studies confirm the major role of proteasomes in transcriptional regulation. Although various post-translational modifications of proteasome subunits have been described, relatively little is known about their functional effect on regulation of proteasome-dependent gene expression. In this article, we talk about the role of proteasomes in control of gene expression and different stages of transcription.
authors.forename: T N
authors.initials: TN
authors.lastname: Moiseeva
authors.forename: A G
authors.initials: AG
authors.lastname: Mittenberg
authors.forename: N A
authors.initials: NA
authors.lastname: Barlev
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D013312:Stress, Physiological / Q000235:genetics; D014158:Transcription, Genetic
chemical_list: D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease