title: A simple allometric diffusion-based biokinetic model to predict Cu(II) uptake across gills of freshwater clam Corbicula fluminea.
abstract: The purpose of this study was to link Fick's type mass transfer and biokinetics together with Michaelis-Menten kinetics to arrive at a simple predictive framework for quantifying biouptake mechanisms in gills of freshwater clam Corbicula fluminea exposed to Cu(II). A diffusion-based Cu(II) influx and permeability can be calculated using physiological and allometric-related parameters. Simulations indicate that Cu(II) bioconcentration factor of gills was 42. Estimated steady-state Cu(II) gill uptake influx and permeability were 0.097 nmol cm(-2) s(-1) and 0.48 cm s(-1), respectively. The proposed simple allometric diffusion-based biokinetic model meets the need for describing nonequilibrium aspects of biouptake mechanisms in bivalve gills.
authors.affiliation: Department of Bioenvironmental Systems Engineering, National Taiwan University, Taipei 10617, Taiwan, ROC.
authors.forename: W-Y
authors.initials: WY
authors.lastname: Chen
authors.forename: C-M
authors.initials: CM
authors.lastname: Lin
authors.forename: Y-R
authors.initials: YR
authors.lastname: Ju
authors.forename: C-M
authors.initials: CM
authors.lastname: Liao
mesh_terms: D000818:Animals; D003300:Copper / Q000493:pharmacokinetics* / Q000633:toxicity; D049874:Corbicula / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D004058:Diffusion; D005618:Fresh Water; D005880:Gills / Q000254:growth & development / Q000378:metabolism*; D008954:Models, Biological; D014018:Tissue Distribution; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics* / Q000633:toxicity
chemical_list: D014874:Water Pollutants, Chemical; D003300:Copper