Auditory hallucinations and brain structure in schizophrenia: voxel-based morphometric study.
We applied voxel-based morphometry to high-resolution magnetic resonance images of 99 participants with schizophrenia. Voxel-wise correlations with a score of auditory hallucination severity identified areas in the left and right superior temporal cortex (including Heschl's gyrus), left supramarginal/angular gyrus, left postcentral gyrus and left posterior cingulate cortex. This study extends previous region-of-interest studies demonstrating main effects of auditory hallucinations related to modality-specific superior temporal areas including primary and secondary auditory cortices.
Nenadic
Igor
I
Department of Psychiatry and Psychotherapy, Friedrich-Schiller-University of Jena, Philosophenweg 3, D-07743 Jena, Germany. igor.nenadic@uni-jena.de
Smesny
Stefan
S
Schlösser
Ralf G M
RG
Sauer
Heinrich
H
Gaser
Christian
C
D000293:Adolescent; D000328:Adult; D000368:Aged; D001303:Auditory Cortex / Q000473:pathology; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping / Q000379:methods; D005260:Female; D006212:Hallucinations / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000473:pathology*; D013702:Temporal Lobe / Q000473:pathology; D055815:Young Adult