Is two better than one? A cross-modal oddball paradigm reveals greater sensitivity of the P300 to emotional face-voice associations.
OBJECTIVE
Studies exploring neurophysiological correlates of main psychiatric disorders have commonly used event-related potentials (ERP) during a visual or an auditory oddball task. The main results concern modulations of the P3b amplitude and/or latency. The present study aims to increase the clinical sensitivity of these P3b modulations by using a more ecological oddball design, using synchronized pairs of audio-visual emotional stimuli.


METHODS
Two groups of healthy participants, one composed of controls and the other of students displaying anxious and depressive tendencies completed visual, auditory and audio-visual (cross-modal) oddball tasks, in which they had to detect deviant happy and sad stimuli among neutral ones as quickly as possible. Behavioral performance and P3b ERP data were analyzed.


RESULTS
Subjects displaying anxious and depressive tendencies exhibited lower P3b amplitude than the controls, but only in the cross-modal oddball task.


CONCLUSIONS
Although the two groups of subjects differed in their levels of co-morbid anxiety and depression, unimodal visual and auditory oddball tasks did not allow us to detect this difference by P3b amplitude modulations, but the cross-modal task did.


CONCLUSIONS
These results suggest that a cross-modal oddball design should be used in future studies to increase the sensitivity of the P300 amplitude differences between healthy participants and those with clinical symptoms.
Campanella
Salvatore
S
Laboratory of Psychological Medicine, Free University of Brussels, Brussels, Belgium. salvatore.campanella@chu-brugmann.be
Bruyer
Raymond
R
Froidbise
Sophie
S
Rossignol
Mandy
M
Joassin
Frédéric
F
Kornreich
Charles
C
Noël
Xavier
X
Verbanck
Paul
P
D000161:Acoustic Stimulation / Q000379:methods; D000293:Adolescent; D001245:Association Learning / Q000502:physiology*; D004644:Emotions / Q000502:physiology*; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005149:Facial Expression; D005260:Female; D006801:Humans; D008297:Male; D010775:Photic Stimulation / Q000379:methods; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D014831:Voice / Q000502:physiology*; D055815:Young Adult