@neurIST: infrastructure for advanced disease management through integration of heterogeneous data, computing, and complex processing services.
The increasing volume of data describing human disease processes and the growing complexity of understanding, managing, and sharing such data presents a huge challenge for clinicians and medical researchers. This paper presents the @neurIST system, which provides an infrastructure for biomedical research while aiding clinical care, by bringing together heterogeneous data and complex processing and computing services. Although @neurIST targets the investigation and treatment of cerebral aneurysms, the system's architecture is generic enough that it could be adapted to the treatment of other diseases. Innovations in @neurIST include confining the patient data pertaining to aneurysms inside a single environment that offers clinicians the tools to analyze and interpret patient data and make use of knowledge-based guidance in planning their treatment. Medical researchers gain access to a critical mass of aneurysm related data due to the system's ability to federate distributed information sources. A semantically mediated grid infrastructure ensures that both clinicians and researchers are able to seamlessly access and work on data that is distributed across multiple sites in a secure way in addition to providing computing resources on demand for performing computationally intensive simulations for treatment planning and research.
Benkner
Siegfried
S
Department, of Scientific Computing, University of Vienna, Vienna 1090, Austria. sigi@par.univie.a.at
Arbona
Antonio
A
Berti
Guntram
G
Chiarini
Alessandro
A
Dunlop
Robert
R
Engelbrecht
Gerhard
G
Frangi
Alejandro F
AF
Friedrich
Christoph M
CM
Hanser
Susanne
S
Hasselmeyer
Peer
P
Hose
Rod D
RD
Iavindrasana
Jimison
J
Köhler
Martin
M
Iacono
Luigi Lo
LL
Lonsdale
Guy
G
Meyer
Rodolphe
R
Moore
Bob
B
Rajasekaran
Hariharan
H
Summers
Paul E
PE
Wöhrer
Alexander
A
Wood
Steven
S
D000783:Aneurysm / Q000628:therapy; D035843:Biomedical Research; D003195:Computer Communication Networks; D016494:Computer Security; D003628:Database Management Systems; D019468:Disease Management; D005060:Europe; D006801:Humans; D033181:Information Dissemination / Q000379:methods*; D008490:Medical Informatics / Q000379:methods*