title: Ex post glycoconjugation of phthalocyanines.
abstract: For the first time, fully fledged phthalocyanines (Pcs) were ex post glycoconjugated, that is, via 1,3-dipolar cycloaddition reaction. This divergent approach gains rapid access to a broad range of highly diverse Pcs bearing chemically sensitive substituents. This will be a breakthrough in generating structure-activity relationships (SAR) for the development of novel bioactive molecules.
authors.affiliation: Department of Chemistry, University of Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany.
authors.forename: Herwig J
authors.initials: HJ
authors.lastname: Berthold
authors.forename: Stephan
authors.initials: S
authors.lastname: Franke
authors.forename: Joachim
authors.initials: J
authors.lastname: Thiem
authors.forename: Theo
authors.initials: T
authors.lastname: Schotten
mesh_terms: D006031:Glycosylation; D007211:Indoles / Q000737:chemistry*; D054833:Isoindoles; D011838:Radiation-Sensitizing Agents; D013329:Structure-Activity Relationship
chemical_list: D007211:Indoles; D054833:Isoindoles; D011838:Radiation-Sensitizing Agents; C013647:phthalocyanine