Synthesis of a DOTA--biotin conjugate for radionuclide chelation via Cu-free click chemistry.
A strain-induced copper-free click reaction mediated by a new and easily prepared cyclooctyne derivative was used to efficiently assemble a DOTA-biotin adduct capable of radionuclide ((68)Ga) uptake. This synthetic strategy offers a potentially general and convenient means of preparing targeted radiolabeling and radiotherapeutic agents.
Schultz
Michael K
MK
Department of Radiology and Radiation Oncology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA. michael-schultz@uiowa.edu
Parameswarappa
Sharavathi G
SG
Pigge
F Christopher
FC
D001710:Biotin / Q000737:chemistry*; D002614:Chelating Agents / Q000138:chemical synthesis* / Q000737:chemistry; D034242:Cyclooctanes / Q000138:chemical synthesis* / Q000737:chemistry; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D015394:Molecular Structure; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry
D002614:Chelating Agents; D034242:Cyclooctanes; D006573:Heterocyclic Compounds, 1-Ring; D019275:Radiopharmaceuticals; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D001710:Biotin