Peripheral T cell lymphoma: new model + new insight.
The nonreceptor tyrosine kinase SYK has recently received a good deal of attention as a critical oncogene in various hematologic malignancies. A newly developed model of peripheral T cell lymphoma (PTCL) using the ITK-SYK fusion gene should serve as a powerful tool to dissect the signaling cascades important for SYK-associated malignancy in the context of t(5;9) PTCL.
Mulloy
James C
JC
Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. james.mulloy@cchmc.org
D000818:Animals; D002895:Chromosomes, Human, Pair 5; D002899:Chromosomes, Human, Pair 9; D004195:Disease Models, Animal; D019337:Hematologic Neoplasms / Q000235:genetics / Q000276:immunology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics / Q000276:immunology*; D051379:Mice; D009857:Oncogenes; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D000072377:Syk Kinase; D013601:T-Lymphocytes / Q000201:enzymology / Q000276:immunology; D014178:Translocation, Genetic
D047908:Intracellular Signaling Peptides and Proteins; D011993:Recombinant Fusion Proteins; D011505:Protein-Tyrosine Kinases; C000606896:SYK protein, human; D000072377:Syk Kinase; C000606897:Syk protein, mouse; C080813:emt protein-tyrosine kinase