Induction of oxidative stress in the epididymis of rats after subchronic exposure to epichlorohydrin.
This study investigated the effects of epichlorohydrin (ECH) on spermatogenesis and antioxidant system in rats. An increase in the incidence of clinical signs, gross pathology and histopathology findings in the epididymidis, and sperm abnormalities and a decrease in the testicular spermatid counts, epididymal sperm counts, and sperm motility were observed at 30 mg/kg/day. Oxidative stress in the epididymal tissue was detected at > or =3.3 mg/kg/day. The results show that graded doses of ECH elicit depletion of antioxidant defense system and that the adverse effects on male reproductive function in ECH-treated rats may be due to the induction of oxidative stress.
Shin
In-Sik
IS
Animal Medical Center, College of Veterinary Medicine, Chonnam National University, Gwangju 500-757, Republic of Korea.
Lim
Jeong-Hyeon
JH
Kim
Sung-Hwan
SH
Kim
Kang-Hyeon
KH
Park
Na-Hyeong
NH
Bae
Chun-Sik
CS
Kang
Seong-Soo
SS
Moon
Changjong
C
Kim
Sung-Ho
SH
Jun
Woojin
W
Kim
Jong-Choon
JC
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004785:Environmental Pollutants / Q000633:toxicity*; D004811:Epichlorohydrin / Q000633:toxicity*; D004822:Epididymis / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D036401:Toxicity Tests, Chronic
D000975:Antioxidants; D004785:Environmental Pollutants; D008054:Lipid Peroxides; D004811:Epichlorohydrin; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases