The Rafts of the Medusa: cholesterol targeting in cancer therapy.
In this issue of Oncogene, Mollinedo and co-workers present promising evidence that cholesterol-sensitive signaling pathways involving lipid rafts can be therapeutically targeted in multiple myeloma. Because the pathways considered in their study are used by other types of tumor cells, one implication of this report is that cholesterol-targeting approaches may be applicable to other malignancies.
Freeman
M R
MR
Urological Diseases Research Center, Children's Hospital Boston, Boston, MA 02115, USA. michael.freeman@childrens.harvard.edu
Di Vizio
D
D
Solomon
K R
KR
D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D009101:Multiple Myeloma / Q000378:metabolism / Q000628:therapy*; D015398:Signal Transduction
D002784:Cholesterol