title: Macular fibrosis in Coats disease.
abstract: OBJECTIVE
  The purpose of this study was to describe the angiographic features and visual impact of macular fibrosis in patients with Coats disease.
  
  
  METHODS
  This is a single institution retrospective case series. Charts of patients diagnosed with Coats disease between 1973 and 2007 were reviewed. Data collected included patient demographics, treatment method, initial and final logarithm of the minimum angle of resolution visual acuity, photographic findings, angiographic characteristics, and anatomical outcome.
  
  
  RESULTS
  Forty-seven patients were identified with adequate imaging and posttreatment follow-up. Average age at presentation was 38 years (4-82 years). Average follow-up was 4.9 years (0-17 years). Macular fibrosis was identified in 11 patients (23%). At presentation, the average logarithm of the minimum angle of resolution visual acuity was as follows: all patients, 0.67; patients with macular fibrosis, 1.14; and patients without macular fibrosis, 0.50 (P = 0.01, 2-tailed Student's t-test). The average posttreatment logarithm of the minimum angle of resolution visual acuity was as follows: all patients, 0.78; patients with macular fibrosis, 0.97; and patients without macular fibrosis, 0.70 (P = 0.26). Macular fibrosis was associated with a pigmented spot at the point of apparent intraretinal vascular anastamosis. Fluorescein angiography showed leakage consistent with neovascularization that appeared to be intraretinal.
  
  
  CONCLUSIONS
  Macular fibrosis is a common finding in Coats disease, occurring in 23% of our patients. It may be a result of intraretinal neovascularization and is associated with a worse vision outcome.
authors.affiliation: West Coast Retina Medical Group, San Francisco, California 94107, USA. JMJumper@WestCoastRetina.com
authors.forename: J Michael
authors.initials: JM
authors.lastname: Jumper
authors.forename: Dustin
authors.initials: D
authors.lastname: Pomerleau
authors.forename: H Richard
authors.initials: HR
authors.lastname: McDonald
authors.forename: Robert N
authors.initials: RN
authors.lastname: Johnson
authors.forename: Arthur D
authors.initials: AD
authors.lastname: Fu
authors.forename: Emmett T
authors.initials: ET
authors.lastname: Cunningham
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002199:Capillary Permeability; D002648:Child; D002675:Child, Preschool; D005122:Exudates and Transudates; D005260:Female; D005355:Fibrosis / Q000175:diagnosis; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D008266:Macula Lutea / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015861:Retinal Neovascularization / Q000175:diagnosis*; D012173:Retinitis / Q000175:diagnosis*; D012189:Retrospective Studies; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult