Comparing biomimetic and biological receptors for insulin sensing.
Biological information such as recognition abilities of antibodies can be transferred to man-made systems by imprinting. For instance, sensor layers with insulin-selective cavities yield similar selectivity and sensitivity as IgG. True "artificial antibodies" are achieved by synthesizing "polymer copies" retaining the original binding properties of anti-insulin IgG via two-step imprinting.
Schirhagl
Romana
R
University of Vienna, Department of Analytical Chemistry, Währingerstrasse 38, 1090 Vienna, Austria.
Podlipna
Dagmar
D
Lieberzeit
Peter A
PA
Dickert
Franz L
FL
D040761:Biomimetic Materials / Q000737:chemistry* / Q000378:metabolism; D032701:Biomimetics / Q000379:methods*; D015374:Biosensing Techniques / Q000379:methods*; D006801:Humans; D007328:Insulin / Q000032:analysis* / Q000378:metabolism; D012680:Sensitivity and Specificity
D007328:Insulin