Strain differences of selective attention in mice: effect of Kamin blocking on classical fear conditioning.
Selective attention was assessed in mice using a classical fear conditioning procedure. Mice were trained by three regimens involving contextual and/or cued conditioning (classical fear conditioning). Most notably, C57BL/6J mice exhibited salient contextual blocking, whereas DBA/2J and ICR mice did not. This study provides a new method to assess the selective attention of mice and describes an animal model for certain human mental disorders, such as schizophrenia.
Yamada
Kazuyuki
K
Support Unit for Animal Experiments, Research Resources Center, Brain Science Institute (BSI), The Institute of Physical and Chemical Research (RIKEN), 2-1 Hirosawa, Wako-city, Saitama 351-0198, Japan. kaz-yamada@brain.riken.jp
D000161:Acoustic Stimulation; D000704:Analysis of Variance; D000818:Animals; D001288:Attention; D001307:Auditory Perception; D003214:Conditioning, Classical; D004597:Electroshock; D005239:Fear; D046352:Freezing Reaction, Cataleptic; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008813:Mice, Inbred ICR; D023421:Models, Animal; D009483:Neuropsychological Tests; D011897:Random Allocation; D013045:Species Specificity