Decreased bone mineral density and vertebral compression fractures in a young adult male with 21-hydroxylase deficiency congenital adrenal hyperplasia (CAH): is CAH an unrecognized population at risk for glucocorticoid-induced osteoporosis?
BACKGROUND
CAH, most often due to a molecular defect in the 21-OH enzyme, results in inadequate cortisol production and subsequent life-long GC replacement.


OBJECTIVE
To heighten awareness for risk of GIO in children with CAH including (1) ongoing assessment of GC dosing, (2) screening for bone health, and (3) prophylactic measures/early intervention once GIO is identified.


METHODS
23 year-old male with 21OHD CAH referred for osteopenia.


METHODS
Chart review; radiological, serological and urine assessment.


RESULTS
Patient has old vertebral compression fractures and diminished BMD, the onset of which likely corresponds to excessive GC dosing during adolescence.


CONCLUSIONS
As with other GC-dependent conditions, children with CAH may represent a previously unrecognized population at risk for GIO. Physicians need to be cognizant of the consequences of excessive GC dosing on bone health, especially during infancy and adolescence, critical periods for both linear growth as well as bone accretion.
Loechner
Karen J
KJ
Division of Pediatric Endocrinology, University of North Carolina, Chapel Hill, NC, USA. karen_loechner@med.unc.edu
Patel
Shipra
S
Fordham
Lynne
L
McLaughlin
James T
JT
D000312:Adrenal Hyperplasia, Congenital / Q000175:diagnosis / Q000453:epidemiology / Q000378:metabolism; D015519:Bone Density; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism; D050815:Fractures, Compression / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000139:chemically induced / Q000517:prevention & control*; D011859:Radiography; D012307:Risk Factors; D016103:Spinal Fractures / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000378:metabolism; D013255:Steroid 21-Hydroxylase / Q000378:metabolism; D055815:Young Adult
D005938:Glucocorticoids; D013255:Steroid 21-Hydroxylase