[Effect of Kidney-Tonifying and Blood-Promoting Recipe on the expression of CD11b/CD18 and Bcl-2/Bax in aged patients with kidney deficiency and blood stasis syndrome].
OBJECTIVE
To study the effect of Kidney-Tonifying plus Blood-Promoting Recipe on the expression of CD11b/CD18 and Bcl-2/Bax in elderly patients with kidney deficiency and blood stasis syndrome.


METHODS
Sixty elderly patients with kidney deficiency and blood stasis syndrome were randomized into two groups. Patients in the treatment group received Kidney-Tonifying plus Blood-Promoting Recipe, and those in the control group receive no treatment. The expression of CD11b/CD18, Bcl-2/Bax, D-Dimeride, CD62p, PAC-I and the rate of platelet aggregation in peripheral blood leukocytes before and after the treatment were examined using flow cytometry in both groups.


RESULTS
The Recipe significantly decreased the levels of CD11b/CD18, D-Dimeride, CD62p, PAC-I and the rate of platelet aggregation (P<0.01), and increased the levels of Bcl-2/Bax (P<0.01).


CONCLUSIONS
Kidney-Tonifying plus Blood-Promoting Recipe regulates CD11b/CD18 and Bcl-2/Bax expression in blood leukocytes and improves microcirculatory status, which can be one of the mechanisms underlying its therapeutic effect in elderly patients.
Hu
Jian
J
Department of Traditional Chinese Medicine, General Hospital of PLA, Beijing 100853, China. hujian301@sohu.com
Yang
Ming-hui
MH
Deng
Xin-li
XL
Lu
Jun-zhang
JZ
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000187:drug effects; D039481:CD11b Antigen / Q000097:blood*; D018821:CD18 Antigens / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy* / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008517:Phytotherapy; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000097:blood; D051028:bcl-2-Associated X Protein / Q000097:blood
C494826:BAX protein, human; D039481:CD11b Antigen; D018821:CD18 Antigens; D004365:Drugs, Chinese Herbal; C509295:ITGAM protein, human; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein