[Proteasomes and their role in transcriptional regulation].
26S proteasome is a multisubunit protein complex that plays a pivotal role in protein degradation. Proteasome's enzymatic activities--proteolytic, ATPase/helicase and RNase--can be used in regulation of multiple cellular processes. Recent studies confirm the major role of proteasomes in transcriptional regulation. Although various post-translational modifications of proteasome subunits have been described, relatively little is known about their functional effect on regulation of proteasome-dependent gene expression. In this article, we talk about the role of proteasomes in control of gene expression and different stages of transcription.
Moiseeva
T N
TN
Mittenberg
A G
AG
Barlev
N A
NA
D000818:Animals; D005786:Gene Expression Regulation; D046988:Proteasome Endopeptidase Complex / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D011499:Protein Processing, Post-Translational; D013312:Stress, Physiological / Q000235:genetics; D014158:Transcription, Genetic
D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease