title: Comparing mfERGs with estimates of cone density from in vivo imaging of the photoreceptor mosaic using a modified Heidelberg retina tomograph.
abstract: The spatial variation in central retinal function determined from mfERG was compared to co-localised measurements of cone density in two normal subjects. Individual cone cells in the parafoveal region of the retina were identified from 1 degrees x1 degrees images of the photoreceptor mosaic using a modified Heidelberg retina tomograph (HRT). The variation in cone density compared well with previous histology and retinal imaging studies and was strongly linearly correlated (r=0.98, p<0.001) with mfERG amplitude within the central retina. Retinal function determined from mfERG amplitude appears to directly reflect the density of the cone cells in this region.
authors.affiliation: Vision Science Research Group, School of Biomedical Sciences, University of Ulster, Coleraine, N. Ireland, UK. wolsley-c@ulster.ac.uk
authors.forename: Clive J
authors.initials: CJ
authors.lastname: Wolsley
authors.forename: Kathryn J
authors.initials: KJ
authors.lastname: Saunders
authors.forename: Giuliana
authors.initials: G
authors.lastname: Silvestri
authors.forename: Roger S
authors.initials: RS
authors.lastname: Anderson
mesh_terms: D004596:Electroretinography / Q000379:methods*; D006801:Humans; D012160:Retina / Q000503:physiopathology*; D017949:Retinal Cone Photoreceptor Cells / Q000166:cytology*; D012684:Sensory Thresholds; D041623:Tomography, Optical Coherence; D014792:Visual Acuity; D014794:Visual Fields