A pH-responsive fluorescence probe and photosensitiser based on a tetraamino silicon(IV) phthalocyanine.
A novel tetraamino silicon(iv) phthalocyanine has been prepared, of which the fluorescence emission and reactive oxygen species generation efficiency are greatly enhanced at lower pH in the range of ca. 5-7, making it a promising pH-controlled and tumour-selective fluorescence probe and photosensitiser for photodynamic therapy.
Jiang
Xiong-Jie
XJ
Department of Chemistry and Centre of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
Lo
Pui-Chi
PC
Yeung
Sin-Lui
SL
Fong
Wing-Ping
WP
Ng
Dennis K P
DK
D000588:Amines / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D054833:Isoindoles; D008113:Liver Neoplasms / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy*; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D017655:Silicon Compounds / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology
D000588:Amines; D005456:Fluorescent Dyes; D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; D017382:Reactive Oxygen Species; D017655:Silicon Compounds; C013647:phthalocyanine