Habitual versus goal-directed action control in Parkinson disease.
This study presents the first direct investigation of the hypothesis that dopamine depletion of the dorsal striatum in mild Parkinson disease leads to impaired stimulus-response habit formation, thereby rendering behavior slow and effortful. However, using an instrumental conflict task, we show that patients are able to rely on direct stimulus-response associations when a goal-directed strategy causes response conflict, suggesting that habit formation is not impaired. If anything our results suggest a disease severity-dependent deficit in goal-directed behavior. These results are discussed in the context of Parkinson disease and the neurobiology of habitual and goal-directed behavior.
de Wit
Sanne
S
Department of Psychology, Amsterdam Center for Study of Adaptive Control in Brain and Behavior (Acacia), University of Amsterdam, Roeterstraat 15, 1018 WB, The Netherlands. s.dewit@uva.nl
Barker
Roger A
RA
Dickinson
Anthony D
AD
Cools
Roshan
R
D000368:Aged; D000704:Analysis of Variance; D001245:Association Learning / Q000187:drug effects / Q000502:physiology; D016022:Case-Control Studies; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology*; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology; D004298:Dopamine / Q000172:deficiency / Q000378:metabolism*; D015259:Dopamine Agents / Q000627:therapeutic use; D006040:Goals; D006184:Habits; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D008875:Middle Aged; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism*; D010300:Parkinson Disease / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012016:Reference Values; D012720:Severity of Illness Index
D015259:Dopamine Agents; D004298:Dopamine