title: A chromone from Seseli praecox (Apiaceae).
abstract: Chemical investigation of the stems of Seseli praecox (Gamisans) Gamisans, an endemic Apiaceae from Sardinia, afforded an isopropenylated chromone (5-hydroxy-6-(2-Z-butenyl-3-hydroxymethyl)-7-methoxy-2-methylchromone), along with four known linear furocoumarins and their natural precursor. For biological characterization the new compound was screened against four cancer cell lines in vitro and showed differential microM antiproliferative effects between suspension and adherent cells.
authors.affiliation: Dipartimento Farmaco Chimico Tecnologico, Università di Cagliari, Facoltà di Farmacia, Cagliari (CA), Italy. marcoleonti@netscape.net
authors.forename: Marco
authors.initials: M
authors.lastname: Leonti
authors.forename: Laura
authors.initials: L
authors.lastname: Casu
authors.forename: Maria Novella
authors.initials: MN
authors.lastname: Solinas
authors.forename: Filippo
authors.initials: F
authors.lastname: Cottiglia
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Caboni
authors.forename: Costantino
authors.initials: C
authors.lastname: Floris
authors.forename: Juerg
authors.initials: J
authors.lastname: Gertsch
authors.forename: Anna Rita
authors.initials: AR
authors.lastname: Saba
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019661:Apiaceae / Q000737:chemistry*; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D019169:Jurkat Cells; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000970:Antineoplastic Agents; D002867:Chromones