title: Management of intraventricular hemorrhage.
abstract: Brain hemorrhage is the most fatal form of stroke and has the highest morbidity of any stroke subtype. Intraventricular extension of hemorrhage (IVH) is a particularly poor prognostic sign, with expected mortality between 50% and 80%. IVH is a significant and independent contributor to morbidity and mortality, yet therapy directed at ameliorating intraventricular clot has been limited. Conventional therapy centers on managing hypertension and intracranial pressure while correcting coagulopathy and avoiding complications such as rebleeding and hydrocephalus. Surgical therapy alone has not changed the natural history of the disease significantly. However, fibrinolysis in combination with extraventricular drainage shows promise as a technique to reduce intraventricular clot volume and to manage the concomitant complications of IVH.
authors.affiliation: Neurosciences Critical Care Division, The Johns Hopkins University School of Medicine, Meyer 8-140, 600 North Wolfe Street, Baltimore, MD 21287, USA. hhinson1@jhmi.edu
authors.forename: Holly E
authors.initials: HE
authors.lastname: Hinson
authors.forename: Daniel F
authors.initials: DF
authors.lastname: Hanley
authors.forename: Wendy C
authors.initials: WC
authors.lastname: Ziai
mesh_terms: D002543:Cerebral Hemorrhage / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D002552:Cerebral Ventricles / Q000503:physiopathology; D004322:Drainage / Q000379:methods; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007427:Intracranial Pressure / Q000502:physiology; D009493:Neurosurgery / Q000379:methods*; D015912:Thrombolytic Therapy / Q000379:methods*