Synthesis and glycogen phosphorylase inhibitor activity of functionalized 1,4-benzodioxanes.
A series of novel 1,4-benzodioxanes 11a-e and rac-12a-d carrying thiazolidine-2,4-dione moiety was synthesized and their glycogen phosphorylase inhibitor activity was also evaluated.
Czakó
Z
Z
Department of Organic Chemistry, Research Group for Carbohydrates of Hungarian Academy of Sciences, Debrecen, Hungary. czakoz@yahoo.com
Docsa
T
T
Gergely
P
P
Juhász
L
L
Antus
S
S
D002855:Chromatography, Thin Layer; D004146:Dioxanes / Q000138:chemical synthesis* / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D024981:Glycogen Phosphorylase / Q000037:antagonists & inhibitors*; D007004:Hypoglycemic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship
D004146:Dioxanes; D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; D007202:Indicators and Reagents; D024981:Glycogen Phosphorylase