title: Trajectories of neighborhood poverty and associations with subclinical atherosclerosis and associated risk factors: the multi-ethnic study of atherosclerosis.
abstract: The authors used data from the Multi-Ethnic Study of Atherosclerosis and latent trajectory class modeling to determine patterns of neighborhood poverty over 20 years (1980-2000 residential history questionnaires were geocoded and linked to US Census data). Using these patterns, the authors examined 1) whether trajectories of neighborhood poverty were associated with differences in the amount of subclinical atherosclerosis (common carotid intimal-media thickness) and 2) associated risk factors (body mass index, hypertension, diabetes, current smoking) at baseline (January 2000-August 2002). The authors found evidence of 5 stable trajectory groups with differing levels of neighborhood poverty ( approximately 6%, 12%, 20%, 30%, and 45%) and 1 group with 29% poverty in 1980 and approximately 11% in 2000. Mostly for women, higher cumulative neighborhood poverty was generally significantly associated with worse cardiovascular outcomes. Trends generally persisted after adjustment for adulthood socioeconomic position and race/ethnicity, although they were no longer statistically significant. Among women who had moved during the 20 years, the long-term measure had stronger associations with outcomes (except smoking) than a single, contemporaneous measure. Results indicate that cumulative 20-year exposure to neighborhood poverty is associated with greater cardiovascular risk for women. In residentially mobile populations, single-point-in-time measures underestimate long-term effects.
authors.affiliation: Department of Epidemiology, University of Michigan, Ann Arbor, USA. emily.lemelin@nih.gov
authors.forename: Emily T
authors.initials: ET
authors.lastname: Murray
authors.forename: Ana V
authors.initials: AV
authors.lastname: Diez Roux
authors.forename: Mercedes
authors.initials: M
authors.lastname: Carnethon
authors.forename: Pamela L
authors.initials: PL
authors.lastname: Lutsey
authors.forename: Hanyu
authors.initials: H
authors.lastname: Ni
authors.forename: Ellen S
authors.initials: ES
authors.lastname: O'Meara
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D002340:Carotid Artery Diseases / Q000453:epidemiology* / Q000208:ethnology / Q000473:pathology; D017536:Carotid Artery, Common / Q000473:pathology*; D016001:Confidence Intervals; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000208:ethnology / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D015999:Multivariate Analysis; D011203:Poverty / Q000706:statistics & numerical data*; D015995:Prevalence; D012111:Residence Characteristics / Q000706:statistics & numerical data*; D012307:Risk Factors; D012959:Socioeconomic Factors; D013223:Statistics as Topic; D011795:Surveys and Questionnaires; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D014481:United States / Q000453:epidemiology