Role of C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome.
Metabolic syndrome is associated with increased propensity for diabetes and cardiovascular disease. Low-grade inflammation is characteristic of metabolic syndrome. C-reactive protein, the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. This review outlines the role of high-sensitivity C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes.
Devaraj
Sridevi
S
University of California Davis Medical Center, Sacramento, CA 95817, USA.
Valleggi
Simona
S
Siegel
David
D
Jialal
Ishwarlal
I
D002097:C-Reactive Protein / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology / Q000209:etiology*; D018450:Disease Progression; D006801:Humans; D015994:Incidence; D007249:Inflammation / Q000097:blood / Q000150:complications; D024821:Metabolic Syndrome / Q000097:blood* / Q000150:complications; D012307:Risk Factors
D002097:C-Reactive Protein