[Influence of mitochondrial oxidative reactions on myocardial contractility. Effects of Ni2+].
Inotropic effects of Ni2+ and mitochondrial oxidative readions were accordingly tested by the use of frog myocardial preparations, excised from left frog ventricle, and rat heart mitochondria (RHM). Amplitude of the cardiac contraction was increased in the presence of 10-200 microM Ni2+ in dose-dependent manner. It was found that Ni2+ is not toxic for RHM. State 4 in a KCI medium was stimulated by 100 microM Ni2+. At the same time, Ni2+ did not affected state 3 and 2,4-dinitrophenol-stimulated respiration of RHM. Our findings allow to be supposed that Ni2+-induced increase in the amplitude of the cardiac contraction can be affected by energetic state of RHM.
Shemarova
I V
IV
Korotkov
S M
SM
Demina
I N
IN
Nesterov
V P
VP
D000818:Animals; D002413:Cations, Divalent; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D009532:Nickel / Q000494:pharmacology*; D010084:Oxidation-Reduction / Q000187:drug effects; D011896:Rana temporaria; D051381:Rats; D017208:Rats, Wistar
D002413:Cations, Divalent; D009532:Nickel