Designing T cells for cancer immunotherapy.
Adoptive transfer of T cells can enhance immune-mediated elimination of tumor cells and provides a specific, non-toxic cancer therapy. This approach has been effective in treating some hematologic and solid malignancies. In addition, the ability to genetically modify T cells to enhance their activity and persistence as well as overcome tumor immune evasion mechanisms has the potential to increase the success of these therapies in a wide range of tumors. In this review we discuss methods for gene transfer and specific modifications that have been made to T cells.
Huye
Leslie E
LE
Center for Cell and Gene Therapy, Baylor College of Medicine, Houston 77030, United States. lehuye@txccc.org
Dotti
Gianpietro
G
D000818:Animals; D018014:Gene Transfer Techniques; D005818:Genetic Engineering; D006801:Humans; D057131:Immune Evasion / Q000276:immunology; D007167:Immunotherapy / Q000379:methods*; D009369:Neoplasms / Q000276:immunology* / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology*