An ACTH-secreting pituitary adenoma within the sphenoid sinus.
A 68-year-old woman developed Cushingoid features three months prior to admission. She was found to have a markedly elevated plasma ACTH-cortisol level. Magnetic resonance imaging (MRI) revealed a mass in the left sphenoidal sinus, which had become enlarged to a point where it could not be removed by transsphenoidal surgery. We decided to proceed with radiation therapy to shrink the tumor. However, it was ineffective. Despite a reduction in serum cortisol levels using metyrapone, she died of septic shock. We describe a rare case of an ACTH-secreting pituitary adenoma within the sphenoid sinus.
Suzuki
Kunihiro
K
Department of Endocrinology and Metabolism, Dokkyo University School of Medicine, Tochigi. kuni-s@dokkyomed.ac.jp
Hattori
Yoshiyuki
Y
Aoki
Chie
C
Nakano
Ayuko
A
Tomizawa
Atsuko
A
Kase
Hiroyuki
H
Kasai
Kikuo
K
D049913:ACTH-Secreting Pituitary Adenoma / Q000175:diagnosis* / Q000532:radiotherapy; D000368:Aged; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy; D013101:Sphenoid Sinus / Q000473:pathology*