Antioxidant-like effects and protective action of transcranial magnetic stimulation in depression caused by olfactory bulbectomy.
We studied the effects of transcranial magnetic stimulation (TMS, 60 Hz and 0.7 mT for 4 h/day for 14 days) on oxidative and cell damage caused by olfactory bulbectomy (OBX) in Wistar rats. The levels of lipid peroxidation products and caspase-3 were enhanced by OBX, whereas it prompted a reduction in reduced glutathione (GSH) content and antioxidative enzymes activities. The treatment with TMS reverted towards normality the biomarkers indicative of oxidative stress and apoptosis. In conclusion, our data show that TMS induced a protection against cell and oxidative damage induced by OBX, as well as they support the hypothesis that oxidative stress may play an important role in depression.
Tasset
Inmaculada
I
Departamento Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Córdoba, Córdoba, Spain.
Drucker-Colín
René
R
Peña
José
J
Jimena
Ignacio
I
Montilla
Pedro
P
Medina
Francisco Javier
FJ
Túnez
Isaac
I
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D053148:Caspase 3 / Q000378:metabolism; D003863:Depression / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D005978:Glutathione / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D015227:Lipid Peroxidation; D008297:Male; D009830:Olfactory Bulb; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D050781:Transcranial Magnetic Stimulation
D000975:Antioxidants; D015415:Biomarkers; D007770:L-Lactate Dehydrogenase; D013482:Superoxide Dismutase; D053148:Caspase 3; D005978:Glutathione