title: Efficacy of intrasinusal administration of bifonazole cream alone or in combination with enilconazole irrigation in canine sino-nasal aspergillosis: 17 cases.
abstract: This study evaluated the effect of 1% bifonazole cream in the treatment of canine sino-nasal aspergillosis (SNA). The cream was instilled through perendoscopically placed catheters into the frontal sinuses and was used either as single therapy after debridement (DC) or as adjunctive therapy after 2% enilconazole infusion (DEC). Twelve dogs were treated initially with DEC: 7 and 3 of these dogs were free of disease after 1 and 2 procedures, respectively, while 2 dogs were cured after DC was used as a second procedure. Five dogs were treated with DC only: in 3 dogs with moderate disease, cure was obtained after a single procedure while, in 2 debilitated patients, cure could not be confirmed. Topical administration of 1% bifonazole cream appears as an effective therapy in SNA, either as an adjunctive therapy to enilconazole infusion or as sole therapy in moderately affected patients.
authors.affiliation: Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, University of Liège, Boulevard de Colonster 20(B44), 4000 Liège, Belgium. fbillen@ulg.ac.be
authors.forename: Frédéric
authors.initials: F
authors.lastname: Billen
authors.forename: Liz-Valery
authors.initials: LV
authors.lastname: Guieu
authors.forename: Frédérique
authors.initials: F
authors.lastname: Bernaerts
authors.forename: Elise
authors.initials: E
authors.lastname: Mercier
authors.forename: Rachel
authors.initials: R
authors.lastname: Lavoué
authors.forename: Charlotte
authors.initials: C
authors.lastname: Tual
authors.forename: Dominique
authors.initials: D
authors.lastname: Peeters
authors.forename: Cécile
authors.initials: C
authors.lastname: Clercx
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001228:Aspergillosis / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D003646:Debridement / Q000379:methods / Q000662:veterinary; D004283:Dog Diseases / Q000188:drug therapy / Q000382:microbiology* / Q000601:surgery; D004285:Dogs; D004359:Drug Therapy, Combination; D005260:Female; D005659:Fungicides, Industrial / Q000627:therapeutic use*; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D009668:Nose Diseases / Q000188:drug therapy / Q000662:veterinary*; D012852:Sinusitis / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D013045:Species Specificity; D007507:Therapeutic Irrigation / Q000379:methods / Q000662:veterinary; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D005659:Fungicides, Industrial; D007093:Imidazoles; C017435:enilconazole; C036596:bifonazole