title: Genetic and biological characterization of avian influenza H5N1 viruses isolated from wild birds and poultry in Western Siberia.
abstract: Three viruses included in the study were isolated from dead birds (A/duck/Omsk/1822/2006, A/chicken/Reshoty/02/2006, and A/duck/Tuva/01/2006), whereas the virus A/common gull/Chany/P/2006 was isolated from an apparently healthy gull during outbreaks of highly pathogenic avian influenza in Russia in 2006. The intravenous pathogenicity index (IVPI) of viruses A/duck/Omsk/1822/2006, A/chicken/Reshoty/02/2006, and A/duck/Tuva/01/2006 ranged from 2.7 to 3.0, while the virus A/common gull/Chany/P/2006 had a markedly lower IVPI of 1.7. The virus A/common gull/Chany/P/2006 had a unique pattern of six amino acid substitutions in the regions of viral proteins crucial for virulence of H5N1 viruses. We hypothesize that these substitutions may affect the pathogenicity of A/common gull/Chany/P/2006.
authors.affiliation: FSRI SRC VB Vector, Novosibirsk, Russia. sharshov@yandex.ru
authors.forename: Kirill
authors.initials: K
authors.lastname: Sharshov
authors.forename: Alesia
authors.initials: A
authors.lastname: Romanovskaya
authors.forename: Roman
authors.initials: R
authors.lastname: Uzhachenko
authors.forename: Alexander
authors.initials: A
authors.lastname: Durymanov
authors.forename: Anna
authors.initials: A
authors.lastname: Zaykovskaya
authors.forename: Olga
authors.initials: O
authors.lastname: Kurskaya
authors.forename: Philipp
authors.initials: P
authors.lastname: Ilinykh
authors.forename: Nikita
authors.initials: N
authors.lastname: Silko
authors.forename: Mikhail
authors.initials: M
authors.lastname: Kulak
authors.forename: Alexander
authors.initials: A
authors.lastname: Alekseev
authors.forename: Sergei
authors.initials: S
authors.lastname: Zolotykh
authors.forename: Alexander
authors.initials: A
authors.lastname: Shestopalov
authors.forename: Iliya
authors.initials: I
authors.lastname: Drozdov
mesh_terms: D000595:Amino Acid Sequence; D019943:Amino Acid Substitution; D000818:Animals; D001717:Birds; D002645:Chickens; D053124:Influenza A Virus, H5N1 Subtype / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity; D005585:Influenza in Birds / Q000453:epidemiology / Q000821:virology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010802:Phylogeny; D012800:Siberia / Q000453:epidemiology; D013047:Specific Pathogen-Free Organisms; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism; D014774:Virulence
chemical_list: D014764:Viral Proteins