title: Chiral Brønsted acid catalyzed enantioselective addition of alpha-isocyanoacetamides to aldehydes.
abstract: A clean and highly efficient enantioselective addition of alpha-isocyanoacetamides to aliphatic aldehydes catalyzed by chiral phosphoric acid in the presence of MS 5 A in toluene at -40 degrees C was developed. Excellent yields (85-98%) and good to excellent enantioselectivities (up to >99% ee) were achieved.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371, Singapore.
authors.forename: Xiaofei
authors.initials: X
authors.lastname: Zeng
authors.forename: Kehan
authors.initials: K
authors.lastname: Ye
authors.forename: Min
authors.initials: M
authors.lastname: Lu
authors.forename: Pei Juan
authors.initials: PJ
authors.lastname: Chua
authors.forename: Bin
authors.initials: B
authors.lastname: Tan
authors.forename: Guofu
authors.initials: G
authors.lastname: Zhong
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D009570:Nitriles / Q000737:chemistry*; D010756:Phosphoric Acids / Q000737:chemistry*; D013237:Stereoisomerism; D014050:Toluene / Q000737:chemistry
chemical_list: D000447:Aldehydes; D009570:Nitriles; D010756:Phosphoric Acids; D014050:Toluene; C031594:2-cyanoacetamide