title: HSP90 and its inhibitors.
abstract: The HSP90 molecular chaperone family is highly conserved and expressed in various organisms ranging from prokaryotes to eukaryotes. HSP90 proteins play essential housekeeping functions, such as controlling the activity, turnover and trafficking of various proteins, promoting cell survival through maintaining the structural and functional integrity of some client proteins which control cell survival, proliferation and apoptosis, and play an important role in the progression of malignant disease. HSP90 proteins are ATP-dependent chaperones and the binding and hydrolysis of ATP are coupled to conformation changes of HSP90, which facilitate client protein folding and maturation. Many natural and synthetic molecular compounds have been proposed as promising cancer therapy via disrupting the formation of complex ATP-HSP90-client proteins.
authors.affiliation: Department of Gastroenterological Surgery, Transplant and Surgical Oncology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
authors.forename: Huifang
authors.initials: H
authors.lastname: Hao
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Naomoto
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Bao
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Watanabe
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Sakurama
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Noma
authors.forename: Takayuki
authors.initials: T
authors.lastname: Motoki
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Tomono
authors.forename: Takuya
authors.initials: T
authors.lastname: Fukazawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shirakawa
authors.forename: Tomoki
authors.initials: T
authors.lastname: Yamatsuji
authors.forename: Junji
authors.initials: J
authors.lastname: Matsuoka
authors.forename: Munenori
authors.initials: M
authors.lastname: Takaoka
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D018841:HSP90 Heat-Shock Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D018841:HSP90 Heat-Shock Proteins