Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma.
Malignant brain tumours continue to be the cause of a disproportionate level of morbidity and mortality across a wide range of individuals. The most common variants in the adult and paediatric populations - malignant glioma and medulloblastoma, respectively - have been the subject of increasingly intensive research over the past two decades that has led to considerable advances in the understanding of their basic biology and pathogenesis. This Review summarizes these developments in the context of the evolving notion of molecular pathology and discusses the implications that this work has on the design of new treatment regimens.
Huse
Jason T
JT
Departments of Pathology, 408 East 69th Street (Z1304), New York, NY 10065, USA.
Holland
Eric C
EC
D000818:Animals; D001932:Brain Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000145:classification / Q000235:genetics* / Q000473:pathology; D005910:Glioma / Q000145:classification / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008527:Medulloblastoma / Q000145:classification / Q000235:genetics* / Q000473:pathology; D057089:Pathology, Molecular / Q000639:trends*