Aortic thrombosis resolved with enoxaparin in a patient treated with cisplatin-based regimen for small cell lung cancer.
We present a rare case of a thrombus at the aortic arch found 1 month after cisplatin-based chemotherapy in a 50-year-old patient with a diagnosis of small cell lung cancer; there were no symptoms related to the thrombus. This patient did not have any predisposing factors for the development of an aortic thrombus before the chemotherapy was initiated. After immediate treatment with low molecular weight heparin (enoxaparin), the thrombus improved without any additional complications. Thus, we suggest that a hypercoagulable status possibly created by both the malignancy and cisplatin-based chemotherapy may have played a significant role in the development of the aortic thrombus.
Chin
Sang Ouk
SO
Department of Medical Oncology and Hematology, East-West Neo Medical Center, Kyung Hee University, #149, Sangil-Dong, Gangdong-Gu, Seoul, 134-090, Republic of Korea.
Lee
Jae Jin
JJ
Hwang
Yeon Hee
YH
Han
Jae Joon
JJ
Maeng
Chi Hoong
CH
Baek
Sun Kyung
SK
Choi
Cheong Woong
CW
D000925:Anticoagulants / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001011:Aorta / Q000187:drug effects / Q000473:pathology*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017984:Enoxaparin / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D055752:Small Cell Lung Carcinoma / Q000150:complications / Q000188:drug therapy*; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology
D000925:Anticoagulants; D000970:Antineoplastic Agents; D017984:Enoxaparin; D002945:Cisplatin