The Src/PI3K/Akt signal pathway may play a key role in decreased drug efficacy in obesity-associated cancer.
Chen
Jiezhong
J
Illawarra Health and Medical Research Institute, University of Wollongong, Wollongong, NSW, Australia. jiezhong@uow.edu.au
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology; D009765:Obesity / Q000150:complications*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D011379:Prognosis; D051057:Proto-Oncogene Proteins c-akt / Q000378:metabolism*; D015398:Signal Transduction; D019061:src-Family Kinases / Q000378:metabolism*
D000970:Antineoplastic Agents; D019869:Phosphatidylinositol 3-Kinases; D019061:src-Family Kinases; D051057:Proto-Oncogene Proteins c-akt