Lentivirus-mediated knockdown of cyclin Y (CCNY) inhibits glioma cell proliferation.
Cyclin Y (CCNY) is a novel cyclin and almost nothing is known about its expression level and role in human cancers. In the present study, we found that lentivirus-mediated RNA interference (RNAi) of CCNY significantly downregulated its expression level. More importantly, knockdown of CCNY inhibited cell proliferation, colony formation, and cell cycle progression in glioma cells. These data suggest that CCNY might play an important role in glioma tumorigenisis.
Xu
YongGang
Y
Department of Minimally Invasive Neurosurgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Wang
Zhi
Z
Wang
Jie
J
Li
JianHua
J
Wang
HongWei
H
Yue
Wu
W
D002453:Cell Cycle; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D016213:Cyclins / Q000037:antagonists & inhibitors* / Q000502:physiology; D005910:Glioma / Q000209:etiology / Q000473:pathology*; D006801:Humans; D016086:Lentivirus / Q000235:genetics*; D034622:RNA Interference
C543319:CCNY protein, human; D016213:Cyclins