title: Roles of preoperative lymphoscintigraphy for sentinel lymph node biopsy in breast cancer patients.
abstract: OBJECTIVE
  To evaluate roles of preoperative lymphoscintigraphy for sentinel lymph node biopsy in breast cancer patients.
  
  
  METHODS
  Five hundred and sixty-five consecutive breast cancer patients were prospectively randomized into groups with or without preoperative lymphoscintigraphy.
  
  
  RESULTS
  In a group with lymphoscintigraphy, 238 patients had sentinel lymph nodes spotted in lymphoscintigram. The visualization of sentinel lymph nodes in lymphoscintigram was not associated with patients' age, primary tumor size and location, histopathologic type and time interval from injection of radiocolloid to lymphoscintigraphy. However, patients with axillary metastasis had a lower identification rate of sentinel lymph nodes by lymphoscintigraphy than those without metastasis (P = 0.003). The identification rate of axillary sentinel lymph nodes was 99.3% in the group and the rate was similar whether there was sentinel lymph nodes spotted in axillary in lymphoscintigram or not (99.6% vs. 98.1%, P = 0.327). The false-negative rate in this group was 4.2%. While in a group without lymphoscintigraphy, the identification rate and the false-negative rate were 99.6% and 4.8%, respectively. There was no significant difference between the two groups in the identification rate of axillary sentinel lymph nodes (P = 0.594) and in the false-negative rate (P = 1.00).
  
  
  CONCLUSIONS
  Preoperative lymphoscintigraphy could neither improve the identification rate nor reduce the false-negative rate of breast cancer sentinel lymph node biopsy, and it is not necessary for sentinel lymph node biopsy in breast cancer patients.
authors.affiliation: Breast Cancer Center, Shandong Cancer Hospital, 440 Jiyan Road, Jinan, Shandong 250117, People's Republic of China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Sun
authors.forename: Juan-juan
authors.initials: JJ
authors.lastname: Liu
authors.forename: Yong-sheng
authors.initials: YS
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Guo-ren
authors.initials: GR
authors.lastname: Yang
authors.forename: Zheng-bo
authors.initials: ZB
authors.lastname: Zhou
authors.forename: Yong-qing
authors.initials: YQ
authors.lastname: Li
authors.forename: Yan-bing
authors.initials: YB
authors.lastname: Liu
authors.forename: Tai-yu
authors.initials: TY
authors.lastname: Li
mesh_terms: D001365:Axilla / Q000000981:diagnostic imaging; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery; D044584:Carcinoma, Ductal / Q000000981:diagnostic imaging* / Q000556:secondary*; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging* / Q000556:secondary*; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging*; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008875:Middle Aged; D011300:Preoperative Care; D011446:Prospective Studies; D011877:Radionuclide Imaging; D021701:Sentinel Lymph Node Biopsy