Fish oil for primary and secondary prevention of coronary heart disease.
Fish consumption and fish oils rich in omega-3 fatty acids were reported to be cardioprotective in both retrospective and prospective studies undertaken over the past two to three decades. In the past several years, there is mounting clinical trial data as well as basic science information supporting the use of fish oil supplements in both primary and secondary cardiovascular prevention. In addition, there appear to be additional benefits to the use of fish oil, including lowering significantly elevated triglyceride levels, preventing atrial fibrillation, reducing mortality rates in congestive heart failure patients, and perhaps stabilizing atherosclerotic plaques. These data have led to specific recommendations for use of omega-3 fatty acids in several cardiovascular areas.
Roth
Eli M
EM
Division of Cardiovascular Diseases, University of Cincinnati College of Medicine & Sterling Research Group, 2230 Auburn Avenue, Cincinnati, OH 45219, USA. eroth@sterlingresearch.org
Harris
William S
WS
D003327:Coronary Disease / Q000097:blood / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage / Q000493:pharmacokinetics; D005395:Fish Oils / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D055502:Secondary Prevention / Q000379:methods*; D016896:Treatment Outcome
D015525:Fatty Acids, Omega-3; D005395:Fish Oils