[Mechanism of blurred vision after brinzolamide instillation].
OBJECTIVE
Eye drops of carbonic anhydrase inhibitor (Brinzolamide) are known to case blurred vision after instillation. Using tear film stability analysis system (TSAS) and functional visual acuity measurement (FVAM) we studied the mechanism of blurred vision.


METHODS
Ten healthy volunteers were studied. Before instillation of brinzolamide 1%, immediately after and at 3, 5, 10 minutes after 1 minutes eye-closure after instillation the breakup index (BUI) of TSAS and FVAM were measured.


RESULTS
Before instillation of brinzolamide 1%, immediately after and at 3, 5, 10 minutes since 1 minutes eye-closure after instillation the BUI of TSAS was 88.3 +/- 1.2, 38.5 +/- 7, 72.1 +/- 4.2, 78.8 +/- 5.1, 83.7 +/- 2.2 respectively, and the FVAM was 1.013 +/- 0.0047, 0.925 +/- 0.029, 1 +/- 0.0075, 1.007 +/- 0.0072, 1.015 +/- 0.0052 respectively. Immediately after 1 minutes eye-closure both BUI and FVAM were low. From 3 minutes after instillation both BUI and FVAM recovered.


CONCLUSIONS
It is suggested that blurred vision after instillation of brinzolamide 1% is associated with the unstableness of tear film. Analyses by TSAS and FVAM are useful to determine both the vision improvement and pharmacokinetics after instillation.
Noguchi
Tsuyoshi
T
Department of Ophthalmology, Matsuyamasekijyuji Hospital, Matsuyama-shi, Ehime-ken, Japan. n0816432494@yahoo.co.jp
Kawasaki
Shiro
S
Mizoue
Shiro
S
Yamaguchi
Masahiko
M
Ohashi
Yuichi
Y
D000328:Adult; D002257:Carbonic Anhydrase Inhibitors / Q000009:adverse effects*; D006801:Humans; D009883:Ophthalmic Solutions / Q000009:adverse effects*; D013449:Sulfonamides / Q000009:adverse effects*; D013666:Tears; D013843:Thiazines / Q000009:adverse effects*; D014792:Visual Acuity / Q000187:drug effects*
D002257:Carbonic Anhydrase Inhibitors; D009883:Ophthalmic Solutions; D013449:Sulfonamides; D013843:Thiazines; C111827:brinzolamide