title: Aortic thrombosis resolved with enoxaparin in a patient treated with cisplatin-based regimen for small cell lung cancer.
abstract: We present a rare case of a thrombus at the aortic arch found 1 month after cisplatin-based chemotherapy in a 50-year-old patient with a diagnosis of small cell lung cancer; there were no symptoms related to the thrombus. This patient did not have any predisposing factors for the development of an aortic thrombus before the chemotherapy was initiated. After immediate treatment with low molecular weight heparin (enoxaparin), the thrombus improved without any additional complications. Thus, we suggest that a hypercoagulable status possibly created by both the malignancy and cisplatin-based chemotherapy may have played a significant role in the development of the aortic thrombus.
authors.affiliation: Department of Medical Oncology and Hematology, East-West Neo Medical Center, Kyung Hee University, #149, Sangil-Dong, Gangdong-Gu, Seoul, 134-090, Republic of Korea.
authors.forename: Sang Ouk
authors.initials: SO
authors.lastname: Chin
authors.forename: Jae Jin
authors.initials: JJ
authors.lastname: Lee
authors.forename: Yeon Hee
authors.initials: YH
authors.lastname: Hwang
authors.forename: Jae Joon
authors.initials: JJ
authors.lastname: Han
authors.forename: Chi Hoong
authors.initials: CH
authors.lastname: Maeng
authors.forename: Sun Kyung
authors.initials: SK
authors.lastname: Baek
authors.forename: Cheong Woong
authors.initials: CW
authors.lastname: Choi
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001011:Aorta / Q000187:drug effects / Q000473:pathology*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D017984:Enoxaparin / Q000627:therapeutic use*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D055752:Small Cell Lung Carcinoma / Q000150:complications / Q000188:drug therapy*; D013927:Thrombosis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000925:Anticoagulants; D000970:Antineoplastic Agents; D017984:Enoxaparin; D002945:Cisplatin