1H, 13C and 15N NMR assignments of RNA recognizing motifs 1 and 2 of BRUNOL-3 protein from human involved in myotonic dystrophy.
BRUNOL-3 protein, an alternate splicing factor, has been known for playing a major role in myotonic dystrophy. It binds to the cTNT m-RNA and prevents splicing of exon-5 region, leading to translation of troponin protein having differential affinity for Ca(2+). Here, we report sequence-specific (1)H, (13)C, and (15)N resonance assignments for RNA recognition motifs 1 and 2 of BRUNOL-3 protein.
Bhatt
Harshesh
H
Structural and Computational Biology Group, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, 110067, India.
Kashyap
Maruthi
M
Bhavesh
Neel Sarovar
NS
D020816:Amino Acid Motifs; D000067878:CELF Proteins; D002247:Carbon Isotopes; D006801:Humans; D006859:Hydrogen; D009223:Myotonic Dystrophy / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000737:chemistry*; D009587:Nitrogen Isotopes; D019906:Nuclear Magnetic Resonance, Biomolecular; D012313:RNA / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000737:chemistry*
D000067878:CELF Proteins; C117363:CELF2 protein, human; D002247:Carbon Isotopes; D009419:Nerve Tissue Proteins; D009587:Nitrogen Isotopes; D016601:RNA-Binding Proteins; D012313:RNA; D006859:Hydrogen