title: Expeditious synthesis of highly substituted indolizinones via a palladium-catalyzed domino sequence.
abstract: A direct one-pot approach to polysubstituted indolizinones from tertiary propargylic alcohols using a palladium-catalyzed domino process involving aminopalladation, reductive elimination, and 1,2-shift is described.
authors.affiliation: Medicinal Chemistry Research Center, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea. ikyon@krict.re.kr
authors.forename: Ikyon
authors.initials: I
authors.lastname: Kim
authors.forename: Kyungsun
authors.initials: K
authors.lastname: Kim
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*
chemical_list: D000480:Alkynes; D007212:Indolizines; D020005:Propanols; D010165:Palladium; C028255:propargyl alcohol