The clinicopathological features of gastric hyperplastic polyps with neoplastic transformations: a suggestion of indication for endoscopic polypectomy.
OBJECTIVE
Although gastric hyperplastic polyps are usually considered as benign lesions, a low risk of carcinomatous conversion is currently recognized. We aimed to identify the characteristics of hyperplastic polyps undergoing neoplastic transformation.


METHODS
A total of 269 gastric hyperplastic polyps from 216 patients removed by endoscopic polypectomy (EP) or surgical resection were enrolled in this study, and their endoscopic pictures and pathology slides were reviewed.


RESULTS
Neoplastic transformation was detected on forceps biopsy specimen in 11 cases. However, the pathology findings from the EP or surgical specimen revealed neoplastic transformation in 14 cases (5.2%; 4 with dysplasia and 10 with adenocarcinoma). No significant difference was found between hyperplastic polyps with and without neoplastic transformation in age, sex, location, number of polyps or gross appearance. However, neoplastic transformations were more frequently found in gastric hyperplastic polyps >1 cm than in polyps </=1 cm (12 of 143; 8.4% vs. 2 of 126; 1.6%) (p=0.013).


CONCLUSIONS
Neoplastic transformations were more frequently found in gastric hyperplastic polyps >1 cm. Therefore, EP should be considered for gastric hyperplastic polyps >1 cm for the accurate diagnosis and definitive treatment.
Han
A-Reum
AR
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Sung
Chang Ohk
CO
Kim
Kyoung Mee
KM
Park
Cheol-Keun
CK
Min
Byung-Hoon
BH
Lee
Jun Haeng
JH
Kim
Jin Yong
JY
Chang
Dong Kyung
DK
Kim
Young-Ho
YH
Rhee
Poong-Lyul
PL
Rhee
Jong Chul
JC
Kim
Jae J
JJ