[Clinical data analysis and chest radiographic features of Wegener's granulomatosis with pulmonary involvement].
OBJECTIVE
To improve the diagnostic accuracy of Wegener's granulomatosis (WG) with pulmonary involvement by analyzing the clinical data and chest radiographic features.


METHODS
The clinical data and chest radiographic features of 43 WG cases with pulmonary involvement were retrospectively analyzed.


RESULTS
Clinically, the patients frequently presented with multi-system involvement, with the incidence of pulmonary involvement of 72.8%. The patients with WG presented with such symptoms in the respiratory system as coughing, expectoration, hemoptysis, and dyspnea. The radiographic manifestations varied among the cases. Nodules and cavitations in the lungs were the signs most frequently found, and patchy infiltration and bronchial narrowing were also observed, which often led to misdiagnosis of WG as other pulmonary diseases.


CONCLUSIONS
WG often has multi-organ involvement, and the lung is one of the most commonly involved organs. The clinical symptoms and radiographic manifestations of WG have no specificity, and the disease can be easily misdiagnosed. Biopsy and ANCA assay can be important means for WG diagnosis.
Kang
Chun-yan
CY
Department of Respiratory Diseases, South Building of General Hospital of PLA, Beijing 100853, China. tangjiahui2004@126.com
Liu
Chang-ting
CT
Wang
Ya-juan
YJ
Li
Tian-zhi
TZ
D000293:Adolescent; D000328:Adult; D000368:Aged; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D001707:Biopsy, Needle; D003951:Diagnostic Errors; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D055815:Young Adult
D019268:Antibodies, Antineutrophil Cytoplasmic