title: Soluble endoglin in preeclamptic patients with or without HELLP syndrome.
abstract: OBJECTIVE
  The pathogenesis of the HELLP (hemolysis, enzyme liver, low platelets) syndrome is unknown. Recently soluble endoglin (sEng) was identified as a cause of the appearance of schistocytes and liver pathology in an animal model of preeclampsia (PE).
  
  
  METHODS
  We explored the value of sEng in 82 women who delivered in a context of normal pregnancy (NP, n = 10), PE (n = 49), or HELLP (n = 23).
  
  
  RESULTS
  sEng was elevated in pathological pregnancies (66.7 +/- 62 and 75.7 +/- 48 pg/mL in PE and HELLP, respectively, vs 5.29 +/- 1.25 in NP, P < .001 for both comparisons) and was correlated with an increase in transaminases (r(2) = 0.17; P = .05), but it was not statistically different between PE and HELLP.
  
  
  CONCLUSIONS
  Although recent literature findings demonstrated a role of sEng in the pathophysiology of HELLP syndrome in animal models, we found that, at the time of delivery, sEng was not specifically elevated in preeclamptic patients with HELLP.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale, Hôpital Tenon, Paris, France. alexandre.hertig@tnn.aphp.fr
authors.forename: Alexandre
authors.initials: A
authors.lastname: Hertig
authors.forename: Julie
authors.initials: J
authors.lastname: Fort
authors.forename: Guillaume
authors.initials: G
authors.lastname: Lefevre
authors.forename: Nathalie
authors.initials: N
authors.lastname: Chabbert-Buffet
authors.forename: Martine
authors.initials: M
authors.lastname: Uzan
authors.forename: Eric
authors.initials: E
authors.lastname: Rondeau
authors.forename: Patrick
authors.initials: P
authors.lastname: Rozenberg
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000097:blood*; D000071063:Endoglin; D005260:Female; D017359:HELLP Syndrome / Q000097:blood*; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011956:Receptors, Cell Surface / Q000097:blood*; D012189:Retrospective Studies; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; D040281:Vascular Endothelial Growth Factor Receptor-1