Chemical synthesis and characterization of palm oil-based difatty acyl thiourea.
Difatty acyl thiourea (DFAT), which has biological activities as antibiotics and antifungal, has been synthesized from palm oil and thiourea using sodium ethoxide as catalyst. Ethyl fatty ester (EFE) and glycerol were produced as by-products. The synthesis was carried out by reflux palm oil with thiourea in ethanol. In this process, palm oil converted to about 81% pure DFAT after 11 hour and molar ratio of thiourea to palm oil was 6.0: 1 at 78 degrees C. Elemental analysis, Fourier transform iInfrared (FTIR) spectroscopy and (1)H nuclear magnetic resonance (NMR) technique were used to characterize both DFAT and EFE.
Hoidy
Wisam H
WH
Department of Chemistry, Faculty of Science, Universiti Putra Malaysia. wisam92@yahoo.com
Ahmad
Mansor B
MB
Al-Mulla
Emad A Jaffar
EA
Yunus
Wan Zin Wan
WZ
Ibrahim
Nor azowa Bt
Na
D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D000431:Ethanol / Q000031:analogs & derivatives / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D000073878:Palm Oil; D010938:Plant Oils / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D013890:Thiourea / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
D000935:Antifungal Agents; D004952:Esters; D005227:Fatty Acids; D010938:Plant Oils; C098088:sodium ethoxide; D000431:Ethanol; D000073878:Palm Oil; D013890:Thiourea