S-adenosylmethionine prevents oxidative stress and modulates glutathione metabolism in TgCRND8 mice fed a B-vitamin deficient diet.
Oxidative stress, altered glutathione levels, and hyperhomocysteinemia play critical roles in Alzheimer's disease. We studied the relationships between hyperhomocysteinemia, glutathione, and oxidative stress in TgCRND8 mice maintained in conditions of folate, B12, and B6 deficiency and the effect of S-adenosylmethionine supplementation. We found that hyperhomocysteinemia was correlated with increased reduced/oxidized brain glutathione ratio, with decreased glutathione S-transferase activity and increased lipid peroxidation. S-adenosylmethionine potentiated superoxide dismutase and glutathione S-transferase activity and restored altered brain glutathione and erythrocytes lipid peroxidation. These results underline the importance of S-adenosylmethionine as neuroprotective compound, acting both on methylation and oxidation metabolism.
Cavallaro
Rosaria A
RA
Department of Surgery Pietro Valdoni, Sapienza University of Rome, Rome, Italy.
Fuso
Andrea
A
Nicolia
Vincenzina
V
Scarpa
Sigfrido
S
D000818:Animals; D004032:Diet; D019587:Dietary Supplements; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism; D006710:Homocysteine / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008745:Methylation; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*; D012436:S-Adenosylmethionine / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism; D014804:Vitamin B Deficiency / Q000235:genetics* / Q000378:metabolism*
D006710:Homocysteine; D012436:S-Adenosylmethionine; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D005978:Glutathione