title: Effects of lifestyle modification on oxidized LDL, reactive oxygen species production and endothelial cell viability in patients with coronary artery disease.
abstract: OBJECTIVE
  We evaluated the effects of lifestyle modification (LM) on lipid profile, oxidative stress and serum-stimulated human coronary artery endothelial cell (HCAEC) viability in coronary artery disease (CAD) patients after 6months.
  
  
  METHODS
  Thirty patients with CAD were randomly assigned to LM intervention (n=15) and usual care control (n=15) groups. LM-intervened patients were instructed to consume low-fat, high-antioxidants and fiber diets. Moderate exercise and stress management were also advised. Group support to maintain patients' compliance was applied.
  
  
  RESULTS
  Serum cholesterol, triglyceride, oxidized LDL and protein carbonyl were decreased in LM group. Serum triglyceride was increased in control group. HCAEC viability was increased, while intracellular reactive oxygen species was decreased, by serum from the LM group.
  
  
  CONCLUSIONS
  LM is capable of improving lipid profile, reducing oxidative stress and increasing HCAEC survival in the patients with CAD, hence lowering a risk for the future cardiovascular event.
authors.affiliation: Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok 10130, Thailand.
authors.forename: Suphot
authors.initials: S
authors.lastname: Srimahachota
authors.forename: Rattiporn
authors.initials: R
authors.lastname: Wunsuwan
authors.forename: Atchasai
authors.initials: A
authors.lastname: Siritantikorn
authors.forename: Chanchai
authors.initials: C
authors.lastname: Boonla
authors.forename: Suttirak
authors.initials: S
authors.lastname: Chaiwongkarjohn
authors.forename: Piyaratana
authors.initials: P
authors.lastname: Tosukhowong
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000378:metabolism*; D004032:Diet; D004043:Dietary Fiber / Q000494:pharmacology; D042783:Endothelial Cells / Q000166:cytology* / Q000187:drug effects; D015444:Exercise / Q000502:physiology*; D005260:Female; D006801:Humans; D008019:Life Style; D008077:Lipoproteins, LDL / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D017382:Reactive Oxygen Species / Q000097:blood / Q000378:metabolism*; D012307:Risk Factors; D013315:Stress, Psychological / Q000628:therapy; D015996:Survival Rate; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D004043:Dietary Fiber; D008077:Lipoproteins, LDL; D017382:Reactive Oxygen Species; D014280:Triglycerides; C099252:oxidized low density lipoprotein; D002784:Cholesterol