Reverse-engineering transcription control networks.
Microarray technologies, which enable the simultaneous measurement of all RNA transcripts in a cell, have spawned the development of algorithms for reverse-engineering transcription control networks. In this article, we classify the algorithms into two general strategies: physical modeling and influence modeling. We discuss the biological and computational principles underlying each strategy, and provide leading examples of each. We also discuss the practical considerations for developing and applying the various methods.
Gardner
Timothy S
TS
Department of Biomedical Engineering, Boston University, 44 Cummington St., Boston, MA 02215, USA.
Faith
Jeremiah J
JJ