title: Porous nanocomposites of PEG-PLA/calcium phosphate: room-temperature synthesis and its application in drug delivery.
abstract: We report room-temperature preparation of poly(ethylene glycol)-block-polylactide (PEG-PLA)/calcium phosphate (CP) nanocomposites with a porous morphology. The reaction time and concentration of the inorganic ingredients play an important role in the morphology and chemical composition of the nanocomposite. Thermogravimetry analysis shows that there is approximately 8.5 wt.% of PEG-PLA block copolymer in the nanocomposite. A typical anti-inflammatory drug, ibuprofen, is used to evaluate the drug loading ability and the release behavior of the porous PEG-PLA/CP nanocomposite. The experiments reveal that the nanocomposite has a higher drug loading capacity and favorable drug release property. The drug release kinetics of the porous PEG-PLA/CP nanocomposite is discussed as a three-stage process. The as-prepared porous PEG-PLA/CP nanocomposite is promising for application in drug delivery.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, 200050, PR China.
authors.forename: Qi-Li
authors.initials: QL
authors.lastname: Tang
authors.forename: Ying-Jie
authors.initials: YJ
authors.lastname: Zhu
authors.forename: You-Rong
authors.initials: YR
authors.lastname: Duan
authors.forename: Qi
authors.initials: Q
authors.lastname: Wang
authors.forename: Ke-Wei
authors.initials: KW
authors.lastname: Wang
authors.forename: Shao-Wen
authors.initials: SW
authors.lastname: Cao
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Jin
authors.initials: J
authors.lastname: Wu
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D002130:Calcium Phosphates / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry; D007052:Ibuprofen / Q000008:administration & dosage; D007700:Kinetics; D053761:Nanocomposites / Q000737:chemistry*; D011091:Polyesters / Q000737:chemistry*; D011092:Polyethylene Glycols / Q000737:chemistry*; D016062:Porosity; D013696:Temperature
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002130:Calcium Phosphates; D004337:Drug Carriers; D011091:Polyesters; D011092:Polyethylene Glycols; C033616:poly(lactide); C020243:calcium phosphate; D007052:Ibuprofen