GWASs and the age of human as the model organism for autoimmune genetic research.
Genetic studies have identified more than 150 autoimmune loci, and next-generation sequencing will identify more. Is it time to make human the model organism for autoimmune research?
Plenge
Robert
R
Brigham and Women's Hospital, Division of Rheumatology, Immunology and Allergy, Boston, MA 02115, USA. rplenge@partners.org
D000483:Alleles; D001327:Autoimmune Diseases / Q000235:genetics; D020022:Genetic Predisposition to Disease; D036281:Genetic Research; D055106:Genome-Wide Association Study; D006801:Humans; D040582:Inheritance Patterns / Q000235:genetics; D008954:Models, Biological; D009154:Mutation / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015203:Reproducibility of Results; D017422:Sequence Analysis, DNA; D013997:Time Factors