title: FDG-PET/CT Imaging Predicts Histopathologic Treatment Responses after Neoadjuvant Therapy in Adult Primary Bone Sarcomas.
abstract: Purpose. The aim of this study was to prospectively evaluate whether FDG-PET allows an accurate assessment of histopathologic response to neoadjuvant treatment in adult patients with primary bone sarcomas. Methods. Twelve consecutive patients with resectable, primary high grade bone sarcomas were enrolled prospectively. FDG-PET/CT imaging was performed prior to the initiation and after completion of neoadjuvant treatment. Imaging findings were correlated with histopathologic response. Results. Histopathologic responders showed significantly more pronounced decreases in tumor FDG-SUVmax from baseline to late follow up than non-responders (64 +/- 19% versus 29 +/- 30 %, resp.; P = .03). Using a 60% decrease in tumor FDG-uptake as a threshold for metabolic response correctly classified 3 of 4 histopathologic responders and 7 of 8 histopathologic non-responders as metabolic responders and non-responders, respectively (sensitivity, 75%; specificity, 88%). Conclusion. These results suggest that changes in FDG-SUVmax at the end of neoadjuvant treatment can identify histopathologic responders and non-responders in adult primary bone sarcoma patients.
authors.affiliation: Ahmanson Biological Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095-1782, USA.
authors.forename: Matthias R
authors.initials: MR
authors.lastname: Benz
authors.forename: Johannes
authors.initials: J
authors.lastname: Czernin
authors.forename: William D
authors.initials: WD
authors.lastname: Tap
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Eckardt
authors.forename: Leanne L
authors.initials: LL
authors.lastname: Seeger
authors.forename: Martin S
authors.initials: MS
authors.lastname: Allen-Auerbach
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Dry
authors.forename: Michael E
authors.initials: ME
authors.lastname: Phelps
authors.forename: Wolfgang A
authors.initials: WA
authors.lastname: Weber
authors.forename: Fritz C
authors.initials: FC
authors.lastname: Eilber