Features of polycythemia vera in the 8p12 myeloproliferative syndrome.
The 8p12 myeloproliferative syndrome is a distinct myeloid disorder associated with a translocation involving chromosome region 8p12 (HUGO nomenclature). It is characterized by leukocytosis, eosinophilia, and a concurrent or rapid transformation to a T-cell lymphoblastic lymphoma. We report a case of polycythemia vera as a clinical presentation of the 8p12 myeloproliferative syndrome and review the literature. Atypical features in patients with polycythemia vera should be investigated with cytogenetic evaluation.
Welborn
Jeanna
J
Department of Internal Medicine and Pathology and Laboratory Medicine, University of California at Davis, Sacramento, CA 95817, USA. jeanna.welborn@ucdmc.ucdavis.edu
Fenner
Shelly
S
Parks
Robert
R
D000015:Abnormalities, Multiple / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D011087:Polycythemia Vera / Q000235:genetics*; D013577:Syndrome; D055815:Young Adult