Epstein-Barr virus-related lymphoproliferative disorders.
Esptein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that persists in carriers as a lifelong, mostly asymptomatic infection. EBV is associated with a variety of lymphomas and lymphoproliferative disorders. In this review we provide an update of the relevant literature on EBV-associated lymphoproliferative disorders, with particular emphasis on epidemiology, pathogenesis, and novel treatment approaches.
Wagner-Johnston
Nina D
ND
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins,1650 Orleans Street, CRB 389, Baltimore, MD 21231, USA.
Ambinder
Richard F
RF
D019264:Adoptive Transfer; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000627:therapeutic use; D058846:Antibodies, Monoclonal, Murine-Derived; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D000998:Antiviral Agents / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000821:virology; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D020031:Epstein-Barr Virus Infections / Q000188:drug therapy / Q000453:epidemiology; D004854:Herpesvirus 4, Human / Q000302:isolation & purification / Q000472:pathogenicity; D006801:Humans; D016867:Immunocompromised Host; D007155:Immunologic Factors / Q000008:administration & dosage / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007167:Immunotherapy; D016131:Lymphocyte Subsets / Q000821:virology; D008223:Lymphoma / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology*; D016483:Lymphoma, AIDS-Related / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology*; D015337:Multicenter Studies as Topic; D016377:Organ Transplantation; D011183:Postoperative Complications / Q000188:drug therapy / Q000453:epidemiology / Q000821:virology; D012367:RNA, Viral / Q000032:analysis; D000069283:Rituximab; D014764:Viral Proteins / Q000032:analysis
D000911:Antibodies, Monoclonal; D058846:Antibodies, Monoclonal, Murine-Derived; D000998:Antiviral Agents; D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D012367:RNA, Viral; D014764:Viral Proteins; D000069283:Rituximab