title: Investigation of serotonin transporter gene promoter (5-HTTLPR) and intron 2 (variable number of tandem repeats) polymorphisms with suicidal behavior in a Turkish population.
abstract: The serotonin (5-hydroxytryptamine) transporter (5HTt) gene has been reported to be associated with suicidal behavior. In this study, we have investigated the 5' promoter region (i.e., 5HTt gene-linked polymorphic region [5-HTTLPR]) and a 17-base pair variable number of tandem repeats polymorphism in the 5HTt gene for potential association with suicidal behavior in a Turkish population. Genotypes were determined for 182 subjects of suicide (86 attempted suicide and 96 completed suicide) and 181 healthy control subjects. Our results showed that allele frequencies at individual loci were not significantly different in the two groups. This absence of altered individual locus haplotype (allele) frequency suggests the lack of a significant genetic contribution by the 5-HTTLPR or variable number of tandem repeats variations to the expression of suicidal tendencies. However, our linkage disequilibrium analyses indicated that there may be a greater risk for suicidal behavior in carriers of the S10 and L12 alleles of 5-HTTLPR.
authors.affiliation: Department of Forensic Medicine, Faculty of Medicine, Gazi University, Ankara, Turkey. tanerakar@yahoo.com
authors.forename: Taner
authors.initials: T
authors.lastname: Akar
authors.forename: Aslihan
authors.initials: A
authors.lastname: Sayin
authors.forename: Zekiye
authors.initials: Z
authors.lastname: Bakkaloğlu
authors.forename: Duygu Kaya
authors.initials: DK
authors.lastname: Cabuk
authors.forename: Sibel
authors.initials: S
authors.lastname: Küçükyildirim
authors.forename: Birol
authors.initials: B
authors.lastname: Demirel
authors.forename: Selçuk
authors.initials: S
authors.lastname: Candansayar
authors.forename: Ergi Deniz
authors.initials: ED
authors.lastname: Ozsoy
authors.forename: Hatice
authors.initials: H
authors.lastname: Mergen
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007438:Introns; D008297:Male; D011110:Polymorphism, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D013405:Suicide; D020080:Tandem Repeat Sequences; D014421:Turkey
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins