Total synthesis of (+/-)-marinopyrrole A and its library as potential antibiotic and anticancer agents.
The first total synthesis of marine natural product, (+/-)-marinopyrrole A, has been accomplished via a nine-step synthesis in an overall yield of 30%. A small focused library based on marinopyrrole has been designed and synthesized. The scope of chemistry was investigated, and a robust chemistry suitable for library synthesis has been developed in the current study. The method that we have developed has made it possible to generate diverse analogues based on structurally novel marinopyrroles for study of potential antibiotic and anticancer activities.
Cheng
Chunwei
C
Key Laboratory of Drug Targeting & Drug Delivery Systems of the Ministry of Education, West China School of Pharmacy, State Key Laboratory of Biotherapy, Sichuan University, Chengdu 610041, China.
Pan
Lili
L
Chen
Yi
Y
Song
Hao
H
Qin
Yong
Y
Li
Rongshi
R
D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D054852:Small Molecule Libraries; D013237:Stereoisomerism
D011758:Pyrroles; D054852:Small Molecule Libraries; C528298:marinopyrrole A