In vivo visualization of alpha-synuclein deposition by carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy]benzoxazole positron emission tomography in multiple system atrophy.
The histopathological hallmark of multiple system atrophy is the appearance of intracellular inclusion bodies, named glial cytoplasmic inclusions, which are mainly composed of alpha-synuclein fibrils. In vivo visualization of alpha-synuclein deposition should be used for the diagnosis and assessment of therapy and severity of pathological progression in multiple system atrophy. Because 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy] benzoxazole could stain alpha-synuclein-containing glial cytoplasmic inclusions in post-mortem brains, we compared the carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy] benzoxazole positron emission tomography findings of eight multiple system atrophy cases to those of age-matched normal controls. The positron emission tomography data demonstrated high distribution volumes in the subcortical white matter (uncorrected P < 0.001), putamen and posterior cingulate cortex (uncorrected P < 0.005), globus pallidus, primary motor cortex and anterior cingulate cortex (uncorrected P < 0.01), and substantia nigra (uncorrected P < 0.05) in multiple system atrophy cases compared to the normal controls. They were coincident with glial cytoplasmic inclusion-rich brain areas in multiple system atrophy and thus, carbon-11-labelled 2-[2-(2-dimethylaminothiazol-5-yl)ethenyl]-6-[2-(fluoro)ethoxy] benzoxazole positron emission tomography is a promising surrogate marker for monitoring intracellular alpha-synuclein deposition in living brains.
Kikuchi
Akio
A
Department of Neurology, Graduate School of Medicine, Tohoku University, Sendai, 980-8574 Japan.
Takeda
Atsushi
A
Okamura
Nobuyuki
N
Tashiro
Manabu
M
Hasegawa
Takafumi
T
Furumoto
Shozo
S
Kobayashi
Michiko
M
Sugeno
Naoto
N
Baba
Toru
T
Miki
Yasuo
Y
Mori
Fumiaki
F
Wakabayashi
Koichi
K
Funaki
Yoshihito
Y
Iwata
Ren
R
Takahashi
Shoki
S
Fukuda
Hiroshi
H
Arai
Hiroyuki
H
Kudo
Yukitsuka
Y
Yanai
Kazuhiko
K
Itoyama
Yasuto
Y
D001583:Benzoxazoles; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D019578:Multiple System Atrophy / Q000000981:diagnostic imaging* / Q000378:metabolism*; D049268:Positron-Emission Tomography / Q000379:methods*; D013844:Thiazoles; D051844:alpha-Synuclein / Q000378:metabolism*
C516779:2-(2-(2-dimethylaminothiazol-5-yl)ethenyl)-6-(2-(fluoro)ethoxy)benzoxazole; D001583:Benzoxazoles; D002250:Carbon Radioisotopes; D013844:Thiazoles; D051844:alpha-Synuclein