title: Use of a doxycycline-enrofloxacin-metronidazole combination with/without diminazene diaceturate to treat naturally occurring canine babesiosis caused by Babesia gibsoni.
abstract: Canine babesiosis is an important worldwide, tick-borne disease caused by hemoprotozoan parasites of the genus Babesia. Babesia gibsoni is the predominant species that causes canine babesiosis in Taipei, Taiwan. It is a small pleomorphic intraerythrocytic parasite that can cause erythrocyte destruction and hemolytic anemia. Efficacy of oral administration of a doxycycline-enrofloxacin-metronidazole combination with and without injections of diminazene diaceturate in the management of naturally occurring canine babesiosis caused by B. gibsoni was evaluated retrospectively. The overall efficacy of this combination of doxycycline-enrofloxacin-metronidazole in conjunction with and without administration of diminazene diaceturate was 85.7% and 83.3%, respectively; with a mean recovery time of 24.2 and 23.5 days, respectively. Concomitant use of intramuscular diminazene diaceturate may not improve the efficacy of a doxycycline-enrofloxacin-metronidazole combination in management of canine babesiosis caused by B. gibsoni.
authors.affiliation: Section of Small Animal Internal Medicine, National Taiwan University Veterinary Hospital, Taipei, Taiwan.
authors.forename: Ming-Yu
authors.initials: MY
authors.lastname: Lin
authors.forename: Hui-Pi
authors.initials: HP
authors.lastname: Huang
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D001403:Babesia / Q000254:growth & development*; D001404:Babesiosis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D004133:Diminazene / Q000031:analogs & derivatives / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy / Q000469:parasitology*; D004285:Dogs; D004318:Doxycycline / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D000077422:Enrofloxacin; D005260:Female; D024841:Fluoroquinolones / Q000627:therapeutic use; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D012189:Retrospective Studies; D013624:Taiwan; D017282:Tick-Borne Diseases / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*
chemical_list: D000981:Antiprotozoal Agents; D024841:Fluoroquinolones; D008795:Metronidazole; D000077422:Enrofloxacin; C003915:diminazene aceturate; D004318:Doxycycline; D004133:Diminazene