Azathioprine-induced liver injury in a patient with multiple autoimmune syndrome.
Extraintestinal manifestations are frequent in patients with ulcerative colitis. They are most commonly associated with active bowel disease but can also occur prior to bowel disease or during a period of remission. The disease often requires long-term therapy. The tolerability of drugs is essential for the comprehensive management of patients. Azathioprine is considered an indispensable drug for the treatment of severe ulcerative colitis patients. It is used to prevent relapse or to treat patients who are refractory to corticosteroids. We report a patient who had alopecia areata, vitiligo, recurrent episcleritis, ulcerative colitis and azathioprine-induced liver injury, and review the related literature.
Okan
Gokhan
G
Department of Dermatology, Medical Park Bahcelievler Hospital, Istanbul, Turkey. gokhanokan8@hotmail.com
Vural
Pervin
P
Peker
Onder
O
Colakoglu
Emel
E
Saruc
Murat
M
D000328:Adult; D001327:Autoimmune Diseases; D001379:Azathioprine / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003093:Colitis, Ulcerative / Q000188:drug therapy*; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D013577:Syndrome
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D001379:Azathioprine; D011241:Prednisone