Non-heme iron(II/III) complexes that model the reactivity of lipoxygenase with a redox switch.
Three ferrous/ferric complexes of a N6 hexadentate ligand, N,N,N',N'-tetrakis(2-benzimidazolyl-methyl)ortho-diamine-trans-cyclohexane (ctb), [Fe(II)(ctb)](ClO(4))(2).EtOH (), [Fe(III)(OEt)(Hctb)](ClO(4))(3).EtOH (), and [Fe(III)(OMe)(Hctb)](ClO(4))(3).3MeOH.4.5H(2)O (), were synthesized and characterized as models of lipoxygenase. The lipoxygenase activities of the complexes were checked and the results indicate that ferrous complex is inactive while ferric alkoxide complexes and show catalytic activity via the hydrogen atom abstraction reaction mechanism.
Mei
Fusheng
F
Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan, 430079, PR China.
Ou
Chunping
C
Wu
Guiling
G
Cao
Li
L
Han
Fang
F
Meng
Xianggao
X
Li
Ji
J
Li
Dongfeng
D
Liao
Zhanru
Z
D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry*; D018360:Crystallography, X-Ray; D005290:Ferric Compounds / Q000737:chemistry*; D005296:Ferrous Compounds / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D008024:Ligands; D008084:Lipoxygenase / Q000737:chemistry* / Q000378:metabolism; D008956:Models, Chemical; D008968:Molecular Conformation; D010084:Oxidation-Reduction
D056831:Coordination Complexes; D005290:Ferric Compounds; D005296:Ferrous Compounds; D008024:Ligands; D007501:Iron; D008084:Lipoxygenase