title: [Impact of C-reactive protein on cardiovascular risk in adolescents].
abstract: BACKGROUND
  Several studies suggest that C-reactive protein (CRP) is associated with coronary artery disease in adults. However, this association has not been thoroughly explored in cases of adolescents.
  
  
  OBJECTIVE
  To evaluate the association between CRP and cardiovascular risk factors in obese adolescents.
  
  
  METHODS
  Eighty-four adolescents (12.6 +/- 1.3 years) of both genders were divided into the following groups: Normal weight (n = 28), Overweight (n = 28), and Obese (n = 28), according to body mass index (BMI). CRP levels (ultrasensitive ELISA), the lipid profile, and anti-oxLDL antibody levels (ELISA) were determined after a 12-hour fast.
  
  
  RESULTS
  The groups were similar in age (p = 0.13) and gender (p = 0.83). Total cholesterol, HDL-C, TC/HDL-C, and LDL-C/HDL-C showed significant differences between Normal weight and Obese groups. There was no significant variation in anti-oxLDL levels. CRP values were different among the three groups (p < 0.01). CRP levels showed a significant association with BMI (beta = 2.533), AC (beta = 2.645), WC (beta = 2.945), TC (beta = 0.006), LDL-C (beta = 0.006), and anti-oxLDL antibodies (beta = 0.383), and a negative association with HDL-C (beta = -0.017).
  
  
  CONCLUSIONS
  The results indicate that CRP is significantly associated with markers of cardiovascular risk in adolescents.
authors.affiliation: Departamento de Nutrição, Universidade de São Paulo, São Paulo, SP, Brasil.
authors.forename: Isis Tande da
authors.initials: IT
authors.lastname: Silva
authors.forename: Letícia Bertoldi
authors.initials: LB
authors.lastname: Sanches
authors.forename: Ana Paula de Queiroz
authors.initials: AP
authors.lastname: Mello
authors.forename: Nágila Raquel Teixeira
authors.initials: NR
authors.lastname: Damasceno
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000175:diagnosis*; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008077:Lipoproteins, LDL / Q000276:immunology; D008297:Male; D009752:Nutritional Status / Q000502:physiology; D009765:Obesity / Q000097:blood*
chemical_list: D015415:Biomarkers; D008055:Lipids; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein; D002097:C-Reactive Protein