title: Evolution of Somatosensory Evoked Potentials after Cardiac Arrest induced hypoxic-ischemic injury.
abstract: OBJECTIVE
  We tested the hypothesis that early recovery of cortical SEP would be associated with milder hypoxic-ischemic injury and better outcome after resuscitation from CA.
  
  
  METHODS
  Sixteen adult male Wistar rats were subjected to asphyxial cardiac arrest. Half underwent 7min of asphyxia (Group CA7) and half underwent 9min (Group CA9). Continuous SEPs from median nerve stimulation were recorded from these rats for 4h immediately following CA, and at 24, 48, and 72h. Clinical recovery was evaluated using the Neurologic Deficit Scale.
  
  
  RESULTS
  All rats in group CA7 survived to 72h, while only 50% of rats in group CA9 survived to that time. Mean NDS values in the CA7 group at 24, 48, and 72h after CA were significantly higher than those of CA9. The N10 (first negative potential at 10ms) amplitude was significantly lower within 1h after CA in rats that suffered longer CA durations. SEPs were also analyzed by separating the rats into good (NDS>or=50) vs. bad (NDS<50) outcomes at 72h, again showing significant difference in N10 and peak-to-peak amplitudes between the two groups. In addition, a smaller N7 potential was consistently observed to recover earlier in all rats.
  
  
  CONCLUSIONS
  The diminished recovery of N10 is associated with longer CA times in rats. Higher N10 and peak-to-peak amplitudes during early recovery are associated with better neurologic outcomes. N7, which may represent thalamic activity, recovers much earlier than cortical responses (N10), suggesting failure of thalamocortical conduction during early recovery.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. wxiong4@jhmi.edu
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Koenig
authors.forename: Jai
authors.initials: J
authors.lastname: Madhok
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Jia
authors.forename: H Adrian
authors.initials: HA
authors.lastname: Puttgen
authors.forename: Nitish V
authors.initials: NV
authors.lastname: Thakor
authors.forename: Romergryko G
authors.initials: RG
authors.lastname: Geocadin
mesh_terms: D000818:Animals; D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D004195:Disease Models, Animal; D005073:Evoked Potentials, Somatosensory; D006323:Heart Arrest / Q000150:complications / Q000401:mortality / Q000628:therapy*; D020925:Hypoxia-Ischemia, Brain / Q000209:etiology / Q000401:mortality / Q000503:physiopathology* / Q000628:therapy; D008297:Male; D011237:Predictive Value of Tests; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome