Empowering malaria vaccination by drug administration.
Although significant progress has been made in clinical development, a protective malaria vaccine remains elusive. Here we review some of the immune subversive mechanisms used by the Plasmodium malaria parasite and propose a potentially effective strategy to achieve complete protection that may serve as a blue print for clinical usage. The premise is to modulate the immune response with drugs that neutralize suppressive functions and potentiate protective responses. Chloroquine may be a first attractive candidate facilitating protective cellular immune responses by improving cross-presentation and reducing suppressive regulatory T cell responses.
Sauerwein
Robert W
RW
Department of Medical Microbiology-268, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. r.sauerwein@mmb.umcn.nl
Bijker
Else M
EM
Richie
Thomas L
TL
D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage* / Q000276:immunology; D002738:Chloroquine / Q000008:administration & dosage* / Q000276:immunology*; D006801:Humans; D017780:Malaria Vaccines / Q000008:administration & dosage* / Q000276:immunology; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control*; D010963:Plasmodium falciparum / Q000187:drug effects / Q000276:immunology*; D014611:Vaccination
D000962:Antimalarials; D017780:Malaria Vaccines; D002738:Chloroquine