Rhodium(III)-catalyzed intermolecular hydroarylation of alkynes.
The rhodium(III)-catalyzed hydroarylation of internal alkynes is described. Good yields are obtained for a variety of alkynes, and excellent regioselectivity is observed for unsymmetrically substituted alkynes. The reaction also gives good yields for a range of arenes. Preliminary mechanistic investigations suggest that this reaction proceeds through arene metalation with the cationic rhodium catalyst, which enables challenging intermolecular reactivity.
Schipper
Derek J
DJ
Centre for Catalysis Research and Innovation, Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada K1N 6N5. dschi064@uottawa.ca
Hutchinson
Marieke
M
Fagnou
Keith
K
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
D000480:Alkynes; D012238:Rhodium