title: Controlled release of 5-aminosalicylic acid (5-ASA) from new biodegradable polyurethanes.
abstract: Segmented polyurethanes containing azo aromatic groups in the main chain were synthesized by reaction of 3,3'-azobis(6-hydroxybenzoic acid) (ABHB), 5-[4-(hydroxyphenyl)azo] salicylic acid (HPAS), and 5-[1-hydroxynaphthyl)azo] salicylic acid (HNAS) with hexamethylenediisocyanate (HDI). All synthesized monomers and polymers were characterized by elemental analysis, FTIR, 1H-NMR spectra, TGA and DSC analysis. All the synthesized azo polymers showed good thermal stability and the onset decomposition temperature of all these polymers was found to be above 195 degrees C under nitrogen atmosphere. The release of 5-ASA under physiological conditions (pH = 7.8 and pH = 1.5) was investigated at body temperature (37 degrees C). The release rate of 5-ASA increased with increasing pH (i.e., 7.8 > 1.5).
authors.affiliation: Petrochemical Research Chair, Chemistry Department, College of Science, King Saud University, Riyadh, Saudi Arabia. ekenawy@ksu.edu.sa
authors.forename: El-Refaie
authors.initials: el-R
authors.lastname: Kenawy
authors.forename: Salem S
authors.initials: SS
authors.lastname: Al-Deyab
authors.forename: Mohamed H
authors.initials: MH
authors.lastname: El-Newehy
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations / Q000737:chemistry / Q000493:pharmacokinetics; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D019804:Mesalamine / Q000737:chemistry / Q000493:pharmacokinetics*; D011140:Polyurethanes / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D011140:Polyurethanes; D019804:Mesalamine