Split-brain syndrome after hepatic transplantation: a tacrolimus-related vasculitis?
An unusual case of inter-haemispheric disconnection syndrome occurring in a patient who had undergone hepatic transplantation is presented. The underlying disorder, at first wrongly interpreted as encephalitis, was found to be severe, diffuse cerebral vasculitis. The hypothesis that treatment with tacrolimus might have caused, or at least favoured the vascular damage is discussed.
Montagnese
Sara
S
Department of Clinical and Experimental Medicine, University of Padova, Padova, Italy.
Schiff
Sami
S
Poci
Carlo
C
Iannizzi
Pamela
P
Biancardi
Anna
A
Manara
Renzo
R
Briani
Chiara
C
Mapelli
Daniela
D
Realdi
Giuseppe
G
Amodio
Piero
P
D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D002533:Cerebral Angiography; D002544:Cerebral Infarction / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D003337:Corpus Callosum / Q000098:blood supply / Q000473:pathology; D004185:Disability Evaluation; D018450:Disease Progression; D017809:Fatal Outcome; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D050812:Split-Brain Procedure / Q000009:adverse effects*; D016559:Tacrolimus / Q000009:adverse effects*; D014657:Vasculitis / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology
D016559:Tacrolimus