title: Building shape models from lousy data.
abstract: Statistical shape models have gained widespread use in medical image analysis. In order for such models to be statistically meaningful, a large number of data sets have to be included. The number of available data sets is usually limited and often the data is corrupted by imaging artifacts or missing information. We propose a method for building a statistical shape model from such "lousy" data sets. The method works by identifying the corrupted parts of a shape as statistical outliers and excluding these parts from the model. Only the parts of a shape that were identified as outliers are discarded, while all the intact parts are included in the model. The model building is then performed using the EM algorithm for probabilistic principal component analysis, which allows for a principled way to handle missing data. Our experiments on 2D synthetic and real 3D medical data sets confirm the feasibility of the approach. We show that it yields superior models compared to approaches using robust statistics, which only downweight the influence of outliers.
authors.affiliation: Computer Science Department, University of Basel, Switzerland. marcel.luethi@unibas.ch
authors.forename: Marcel
authors.initials: M
authors.lastname: Lüthi
authors.forename: Thomas
authors.initials: T
authors.lastname: Albrecht
authors.forename: Thomas
authors.initials: T
authors.lastname: Vetter
mesh_terms: D000465:Algorithms; D016477:Artifacts; D003198:Computer Simulation; D003627:Data Interpretation, Statistical; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008953:Models, Anatomic; D008954:Models, Biological; D015233:Models, Statistical; D011856:Radiographic Image Enhancement / Q000379:methods; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012886:Skull / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed / Q000379:methods*