title: Identification of a novel HLA-A allele, HLA-A*0355, in a Brazilian family of eastern European descendents.
abstract: The new human leukocyte antigen (HLA) class I allele, HLA-A*0355 was identified in a Brazilian family. Our sequence analysis detected a mismatch located in exon 2, codon 86, at position 258 (C-->A) that results in a nonsilent and nonconservative substitution with the replacement of asparagine by lysine. Substitutions located at this oligosaccharide attachment site of the protein were observed in only other four classic HLA class I sequences, indicating a highly conserved peptide site however its function remains unknown.
authors.affiliation: Laboratory of Immunogenetics and Histocompatibility, Genetics Department, Universidade Federal do Paraná, Curitiba, Brazil.
authors.forename: Sibelle Botogosque
authors.initials: SB
authors.lastname: Mattar
authors.forename: Clineu Julien Seki
authors.initials: CJ
authors.lastname: Uehara
authors.forename: Fernanda
authors.initials: F
authors.lastname: Ribas
authors.forename: Fabiana
authors.initials: F
authors.lastname: Poerner
authors.forename: Gorete Ynaquievi Tomaz
authors.initials: GY
authors.lastname: de Rezende
authors.forename: Rafael Gustavo
authors.initials: RG
authors.lastname: Vargas
authors.forename: Pryscilla Fanini
authors.initials: PF
authors.lastname: Wowk
authors.forename: Maria
authors.initials: M
authors.lastname: da Graça Bicalho
mesh_terms: D000328:Adult; D000483:Alleles; D019943:Amino Acid Substitution / Q000235:genetics; D001483:Base Sequence / Q000235:genetics; D001938:Brazil; D003001:Cloning, Molecular; D005061:Europe, Eastern / Q000208:ethnology; D005260:Female; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics*; D015789:HLA-A2 Antigen; D015791:HLA-A3 Antigen; D006239:Haplotypes; D006650:Histocompatibility Testing; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D035781:Siblings; D044465:White People / Q000235:genetics*
chemical_list: D015234:HLA-A Antigens; C435939:HLA-A*02:01 antigen; C442141:HLA-A*03:01 antigen; D015789:HLA-A2 Antigen; D015791:HLA-A3 Antigen