A case of severe MAGIC syndrome treated successfully with the tumor necrosis factor-alpha inhibitor infliximab.
We report a patient with an overlap of relapsing polychondritis and Behcet disease whose cartilaginous inflammation and genital lesions were refractory to corticosteroids and immunosuppressants, but fully remitted with the tumor necrosis factor-alpha inhibitor, infliximab. We believe this case represents the first report of a response to a tumor necrosis factor inhibitor in a patient with mouth and genital ulcerations with inflamed cartilage syndrome.
Geissal
Erik D
ED
Department of Medical Education, Providence Portland Medical Center, Portland, OR 97213, USA.
Wernick
Richard
R
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001528:Behcet Syndrome / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D000069285:Infliximab; D008297:Male; D011081:Polychondritis, Relapsing / Q000150:complications* / Q000188:drug therapy*; D012074:Remission Induction; D013577:Syndrome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D014409:Tumor Necrosis Factor-alpha; D000069285:Infliximab