title: Anterior vaginal wall prolapse: a randomized controlled trial of SIS graft versus traditional colporrhaphy.
abstract: OBJECTIVE
  This study seeks to compare the small intestine submucosa (SIS) graft with traditional colporrhaphy (TC) for surgical treatment of anterior vaginal prolapse.
  
  
  METHODS
  Subjects were randomly assigned to SIS (n = 29) or to TC (n = 27) preoperatively and outcomes analyzed at 12 months postoperatively. The primary outcome was the absence of POP-Q stage >or= II prolapse, and secondary outcome was improvement in quality of life. Data were compared with independent samples or paired Student's t test.
  
  
  RESULTS
  SIS group had 86.2% anatomic cure compared to 59.3% in TC (p = 0.03). SIS improved point Ba measurement significantly (-1.93 cm versus -1.37 cm, p = 0.02). Both operations significantly improved quality of life, although there were no differences between the groups. We observed a greater number of complications in the SIS group, with no infections or erosion.
  
  
  CONCLUSIONS
  SIS repair improved point Ba significantly. However, there were no differences observed in quality of life between the techniques.
authors.affiliation: Section of Urogynecology and Pelvic Surgery, Department of Gynecology, Universidade Federal de São Paulo, Rua dos Otonis, 601 (Vila Clementino), 04025-001, São Paulo, SP, Brazil. pfeldner@alfa.epm.br
authors.forename: Paulo Cezar
authors.initials: PC
authors.lastname: Feldner
authors.forename: Rodrigo Aquino
authors.initials: RA
authors.lastname: Castro
authors.forename: Luiz Antonio
authors.initials: LA
authors.lastname: Cipolotti
authors.forename: Carlos Antonio
authors.initials: CA
authors.lastname: Delroy
authors.forename: Marair Gracio Ferreira
authors.initials: MG
authors.lastname: Sartori
authors.forename: Manoel João Batista Castello
authors.initials: MJ
authors.lastname: Girão
mesh_terms: D020884:Colpotomy / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007413:Intestinal Mucosa / Q000637:transplantation*; D008875:Middle Aged; D011788:Quality of Life; D011795:Surveys and Questionnaires; D013997:Time Factors; D016896:Treatment Outcome; D014596:Uterine Prolapse / Q000601:surgery*