title: beta-Resorcylic acid lactones from a Paecilomyces fungus.
abstract: Six new beta-resorcylic acid lactones (1-6), named paecilomycins A-F, and five known compounds, aigilomycin B (7), zeaenol (8), aigialomycin D (9), aigialomycin F (10), and aigialospirol, were isolated from the mycelial solid culture of Paecilomyces sp. SC0924. Their structures were elucidated by extensive NMR analysis, single-crystal X-ray study, and chemical correlations. Compounds 5 and 10 exhibited antiplasmodial activity against Plasmodium falciparum line 3D7 with IC(50) values of 20.0 and 10.9 nM, respectively, and compounds 5-7 showed moderate activity against the P. falciparum line Dd2.
authors.affiliation: Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Xingke Road 723, Tianhe District, Guangzhou 510650, People's Republic of China.
authors.forename: Liangxiong
authors.initials: L
authors.lastname: Xu
authors.forename: Zhengxiang
authors.initials: Z
authors.lastname: He
authors.forename: Jinghua
authors.initials: J
authors.lastname: Xue
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Chen
authors.forename: Xiaoyi
authors.initials: X
authors.lastname: Wei
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D062385:Hydroxybenzoates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D047028:Macrocyclic Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification; D008968:Molecular Conformation; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010143:Paecilomyces / Q000737:chemistry*; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D062385:Hydroxybenzoates; D007783:Lactones; D047028:Macrocyclic Compounds; D018942:Macrolides; C452445:aigialomycin D; C000601938:paecilomycin B; C017704:beta-resorcylic acid