title: Evolution of the thrombolytic treatment window for acute ischemic stroke.
abstract: Ischemic stroke is a major cause of morbidity and mortality for which the only approved treatment in the acute setting is intravenous thrombolysis. The efficacy and safety of recombinant tissue plasminogen activator (rt-PA) have been firmly established within 3 h of symptom onset; however, few patients are eligible for treatment in this time window. Expanding the time for treatment has been challenging, but new evidence has demonstrated a modest statistical improvement in selected patients when rt-PA is administered within 4.5 h. This important finding hopefully will enable more patients to receive treatment and simultaneously provides an opportunity to reaffirm that the benefits of rt-PA diminish with time.
authors.affiliation: University of California, San Diego, Medical Office North, Third Floor, Suite 3, 200 West Arbor Drive, #8466, San Diego, CA, 92103, USA. astemer@ucsd.edu
authors.forename: Andrew
authors.initials: A
authors.lastname: Stemer
authors.forename: Patrick
authors.initials: P
authors.lastname: Lyden
mesh_terms: D002545:Brain Ischemia / Q000150:complications; D004311:Double-Blind Method; D006801:Humans; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic; D020521:Stroke / Q000188:drug therapy*; D015912:Thrombolytic Therapy / Q000379:methods*; D013997:Time Factors; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D010959:Tissue Plasminogen Activator