Effect of fructose-1,6-bisphosphate on the nephrotoxicity induced by cisplatin in rats.
Cisplatin is one of the most active cytotoxic agents in the treatment of cancer, but its clinical use is frequently limited by nephrotoxicity. The study presented here attempted to evaluate the effect of fructose-1,6-bisphosphate in the cisplatin-induced nephrotoxicity in rats. The drugs were administered intraperitoneally as a single dose: sodium chloride 0.9%, cisplatin (6 mg/kg), fructose-1,6-bisphosphate (500 mg/kg), and cisplatin plus fructose-1,6-bisphosphate (6 and 500 mg/kg, respectively). The use of cisplatin resulted in significant elevation of serum creatinine and urea. The group that received cisplatin plus fructose-1,6-bisphosphate presented a significantly lower level of creatinine and urea compared to the cisplatin group. Acute tubular necrosis was demonstrated in the animals that received cisplatin and a less severe one in the cisplatin plus fructose-1,6-bisphosphate group. Fructose-1,6-bisphosphate has a protective effect over renal function and renal parenchyma in a rat experimental model of cisplatin-induced nephrotoxicity. The anti-inflammatory effect of fructose-1,6-bisphosphate confirms its protective effect in cases of cellular injury.
Azambuja
Alan Arrieira
AA
Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul (HSL PUCRS), Porto Alegre, Rio Grande do Sul, Brasil.
Lunardelli
Adroaldo
A
Nunes
Fernanda Bordignon
FB
Gaspareto
Patrick Barcelos
PB
Donadio
Márcio Vinícius Fagundes
MV
Poli de Figueiredo
Carlos Eduardo
CE
de Oliveira
Jarbas Rodrigues
JR
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000517:prevention & control; D000818:Animals; D002945:Cisplatin / Q000633:toxicity*; D003404:Creatinine / Q000097:blood; D019610:Cytoprotection; D005635:Fructosediphosphates / Q000008:administration & dosage / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007683:Kidney Tubular Necrosis, Acute / Q000139:chemically induced* / Q000517:prevention & control; D008297:Male; D009336:Necrosis; D009569:Nitric Oxide / Q000097:blood; D019001:Nitric Oxide Synthase / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D014508:Urea / Q000097:blood; D015431:Weight Loss / Q000187:drug effects
D005635:Fructosediphosphates; D009569:Nitric Oxide; D014508:Urea; D003404:Creatinine; D019001:Nitric Oxide Synthase; C029063:fructose-1,6-diphosphate; D002945:Cisplatin