title: [Association between endometrial cancer and metabolic syndrome].
abstract: OBJECTIVE
  To study the association between endometrioid uterine carcinomas and metabolic syndrome (MS).
  
  
  METHODS
  A retrospective study was conducted on 123 patients who were admitted in Department of Gynecology Oncology, Zhejiang Cancer Hospital (study group) and 90 healthy women (control group) with matching age from Jan. 2005 to Mar. 2009. The general conditions [including age, whether menopausal, body mass index (BMI)]; the risk factors for MS [including waist circumference, fasting plasma glucose, triglycerides (TG), high-density lipoprotein (HDL) and systolic and diastolic blood pressure] were analyzed. The clinical stage, histological type, and pathology differentiated degree of study group with or without MS were also analyzed by univariate analysis and Cox proportional hazards models.
  
  
  RESULTS
  (1) The univariate survival analysis shown that there were no significant difference with age in two groups [(54.3 +/- 0.6) vs. (54.2 +/- 0.9) years; P > 0.05], while the rate of menopausal, BMI (> or = 25 kg/m(2)), the cases coupled with MS, the size of waist circumference (> 80 cm), the level of fasting plasma glucose (> or = 5.6 mmol/L), TG (> 1.7 mmol/L) and abnormal systolic and diastolic blood pressure in study group were higher than those in control group (67.5% vs. 48.9%, 45.5% vs. 23.3%, 43.9% vs. 18.9%, 50.4% vs. 27.8%, 53.7% vs. 21.1%, 40.7% vs. 21.1% and 40.7% vs. 25.6%, respectively, all P < 0.05). The percentage of HDL (< 1.30 mmol/L) was higher in study group than that in control group (63.4% vs. 32.2%, P < 0.05). (2) There were not significant difference for the clinical stage, pathological type, grades between patients with or without MS in study group (P > 0.05). (3) The Logistic multivariate survival analysis shown that central obesity, higher TG, lower HDL and abnormal plasma glucose were independent risk factors for endometrioid uterine carcinomas coupled with MS (P < 0.05).
  
  
  CONCLUSIONS
  Metabolic syndrome is marginally associated with an increased risk of endometrioid uterine carcinomas, which may be the new point to screen, prevention and treatment endometrioid uterine carcinomas.
authors.affiliation: Department of Gynecology Oncology, Zhejiang Cancer Hospital, Hangzhou 310006, China.
authors.forename: Hua-feng
authors.initials: HF
authors.lastname: Shou
authors.forename: Juan
authors.initials: J
authors.lastname: Ni
authors.forename: Tao
authors.initials: T
authors.lastname: Zhu
authors.forename: Jian-hong
authors.initials: JH
authors.lastname: Chen
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiao-xian
authors.initials: XX
authors.lastname: Xu
authors.forename: Lu
authors.initials: L
authors.lastname: Chen
authors.forename: Hua
authors.initials: H
authors.lastname: Yu
mesh_terms: D000230:Adenocarcinoma / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D016022:Case-Control Studies; D016889:Endometrial Neoplasms / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D024821:Metabolic Syndrome / Q000097:blood / Q000150:complications*; D008875:Middle Aged; D009367:Neoplasm Staging; D009765:Obesity / Q000097:blood / Q000150:complications*; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D049629:Waist-Hip Ratio
chemical_list: D001786:Blood Glucose; D008075:Lipoproteins, HDL; D014280:Triglycerides