Pyridine-based heterocycles. Synthesis of new pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and related heterocycles.
The synthesis of the title compounds was achieved using ethyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (1) as starting material. The reaction of the amino ester 1 with phenylisothiocyanate in boiling ethanol afforded the thiourea derivative 5. The cyclization reactions of 5 under different reaction conditions led to different pyridothienopyrimidine derivatives. Other reactions of the latter derivatives leading to pyrido[4',3':4,5]thieno[2,3-d]triazolo[1,5-a]pyrimidines are also presented.
El-Kashef
Hussein
H
Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt. elkashef@aun.edu.eg
Farghaly
Abdel-Rahman
AR
Al-Hazmi
Ahmed
A
Terme
Thierry
T
Vanelle
Patrice
P
D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D011725:Pyridines / Q000138:chemical synthesis*; D011743:Pyrimidines / Q000138:chemical synthesis*
D006571:Heterocyclic Compounds; D011725:Pyridines; D011743:Pyrimidines