title: Longitudinal study of the diagnosis of components of the metabolic syndrome in individuals with binge-eating disorder.
abstract: BACKGROUND
  Binge-eating disorder may represent a risk factor for the metabolic syndrome.
  
  
  OBJECTIVE
  The objective was to assess longitudinally the relation between binge-eating disorder and components of the metabolic syndrome.
  
  
  METHODS
  At 2.5 and 5 y of follow-up, 134 individuals with binge-eating disorder and 134 individuals with no history of eating disorders, who were frequency-matched for age, sex, and baseline body mass index (BMI), were interviewed during the follow-up interval regarding new diagnoses of 3 metabolic syndrome components: hypertension, dyslipidemia, and type 2 diabetes.
  
  
  RESULTS
  A comparison of individuals with and without a binge-eating disorder in analyses adjusted for age, sex, baseline BMI, and interval BMI change had hazard ratios (95% CIs) for reporting new diagnoses of metabolic syndrome components of 2.2 (1.2, 4.2; P = 0.023) for dyslipidemia, 1.5 (0.76, 2.9; P = 0.33) for hypertension, 1.6 (0.77, 3.9; P = 0.29) for type 2 diabetes, 1.7 (1.1, 2.6; P = 0.023) for any component, and 2.4 (1.1, 5.7; P = 0.038) for > or =2 components.
  
  
  CONCLUSIONS
  Binge-eating disorder may confer a risk of components of the metabolic syndrome over and above the risk attributable to obesity alone. This trial was registered at www.clinicaltrials.gov as NCT00777634.
authors.affiliation: McLean Hospital, Belmont, MA 02478, USA. jhudson@mclean.harvard.edu <jhudson@mclean.harvard.edu>
authors.forename: James I
authors.initials: JI
authors.lastname: Hudson
authors.forename: Justine K
authors.initials: JK
authors.lastname: Lalonde
authors.forename: Caitlin E
authors.initials: CE
authors.lastname: Coit
authors.forename: Ming T
authors.initials: MT
authors.lastname: Tsuang
authors.forename: Susan L
authors.initials: SL
authors.lastname: McElroy
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Crow
authors.forename: Cynthia M
authors.initials: CM
authors.lastname: Bulik
authors.forename: Margo S
authors.initials: MS
authors.lastname: Hudson
authors.forename: Jack A
authors.initials: JA
authors.lastname: Yanovski
authors.forename: Norman R
authors.initials: NR
authors.lastname: Rosenthal
authors.forename: Harrison G
authors.initials: HG
authors.lastname: Pope
mesh_terms: D000328:Adult; D056912:Binge-Eating Disorder / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000378:metabolism; D050171:Dyslipidemias / Q000175:diagnosis / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis / Q000378:metabolism; D007407:Interviews as Topic; D053208:Kaplan-Meier Estimate; D008137:Longitudinal Studies; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000378:metabolism; D008875:Middle Aged