Epithelioid hemangioendothelioma in the right auricle of an adult, male Rhesus macaque (Macaca mulatta).
BACKGROUND
A 9-year-old, male castrate, Rhesus macaque was euthanized following a prolonged history of chronic renal failure.


RESULTS
Necropsy revealed a proliferative lesion within the right cardiac auricle composed of neoplastic epithelioid cells which infiltrated the myocardium and frequently exhibited intracytoplasmic luminae. Cells multifocally exhibited strong cytoplasmic immunoreactivity for Factor VIII-related protein (von Willebrand's factor).


CONCLUSIONS
The histological characteristics of this tumor are consistent with a diagnosis of epithelioid hemangioendothelioma, an intermediate-grade vasoformative neoplasm which has to our knowledge not previously been reported in the heart of a non-human species.
Lombardini
E D
ED
Department of Veterinary Pathology, Armed Forces Institute of Pathology, Washington DC, USA. eric.lombardini@us.army.mil
Virmani
R
R
Blanchard
T W
TW
Lafond
J F
JF
Ménard
S
S
Doré
M
M
D000818:Animals; D006325:Heart Atria / Q000473:pathology; D006338:Heart Neoplasms / Q000473:pathology / Q000662:veterinary*; D018323:Hemangioendothelioma, Epithelioid / Q000473:pathology / Q000662:veterinary*; D008253:Macaca mulatta; D008297:Male; D008992:Monkey Diseases / Q000473:pathology*