title: Cervical cancer and human papillomavirus in indigenous Guyanese women.
abstract: OBJECTIVE
  The purpose of this study was to determine the prevalence of cervical disease, human papillomavirus infection, and human papillomavirus (HPV) genotypes in indigenous villages of Guyana.
  
  
  METHODS
  This is a retrospective analysis of a clinical cervical cancer screening and treatment program: 2250 women underwent cytologic screening; 1423 women were concomitantly screened for HPV. HPV genotyping was performed in 45 women with high-grade dysplasia and in 9 women with cervical carcinoma.
  
  
  RESULTS
  We found invasive cervical carcinoma in 0.80% of the women, cervical intraepithelial neoplasia II and III in 5.07% of the women, and a high-risk HPV infection rate in 19.3% of the women, all of which peaked between the ages of 20-30 years. Sixteen genotypes were detected in women with high-grade dysplasia or cancer: HPV 31, 25.0%; HPV 16, 22.7%; HPV 18, 13.6%. The rate of HPV 16 and 18 in cervical cancer was 55.50%.
  
  
  CONCLUSIONS
  Indigenous Guyanese women have a high rate of cervical cancer and high-grade dysplasia, with an apparent predominance of HPV 16 and 18 in invasive cancer and overrepresentation of HPV 31 in high-grade dysplasia.
authors.affiliation: Department of Obstetrics and Gynecology, University of Virginia, Charlottesville, VA, USA.
authors.forename: Rebecca S
authors.initials: RS
authors.lastname: Kightlinger
authors.forename: William P
authors.initials: WP
authors.lastname: Irvin
authors.forename: Kellie J
authors.initials: KJ
authors.lastname: Archer
authors.forename: Nancy W
authors.initials: NW
authors.lastname: Huang
authors.forename: Raeleen A
authors.initials: RA
authors.lastname: Wilson
authors.forename: Jacqueline R
authors.initials: JR
authors.lastname: Doran
authors.forename: Neil B
authors.initials: NB
authors.lastname: Quigley
authors.forename: JoAnn V
authors.initials: JV
authors.lastname: Pinkerton
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000208:ethnology* / Q000235:genetics; D055088:Early Detection of Cancer; D005260:Female; D006172:Guyana / Q000453:epidemiology; D052162:Human papillomavirus 16 / Q000235:genetics; D052161:Human papillomavirus 18 / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000208:ethnology* / Q000235:genetics; D044382:Population Groups; D015995:Prevalence; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000208:ethnology* / Q000235:genetics; D002578:Uterine Cervical Dysplasia / Q000208:ethnology* / Q000235:genetics