Identification of a new anti-diabetic agent by combining VOSO4 and vitamin E in a single molecule: studies on its spectral, thermal and pharmacological properties.
Vanadium(IV) complex of vitamin E (Vit E) ligand was reported. In this complex, binuclear ligand acts as a monodentate via oxygen of phenolic group. The vanadyl(II) ion is surrounded by two molecules of Vit E and two water molecules. The [VO(Vit E)(2)(H(2)O)(2)]2H(2)O complex was isolated by the reaction between VOSO(4) and vitamin E in ethanol/water solvent (50/50 w/w) at pH=8. The solid vanadyl(II) complex has been characterized by elemental analyses (CHN), photometric titrations, infrared spectra, molar conductivity, electronic spectra, TGA/DSC, SEM and XRD studies. Electronic and magnetic measurements are confirmed that the speculated geometry of vanadyl(II) complex is square pyramidal geometry. The microbial test was performed for the vanadyl complex against some kinds of bacteria and fungi. The [VO(Vit E)(2)(H(2)O)(2)]2H(2)O complex was proved effective in addressing diabetic of type I in case of experimental animal than other compounds were prepared in the literature.
Refat
Moamen S
MS
Department of Chemistry, Faculty of Science, Port Said 42111, Suez Canal University, Egypt. msrefat@yahoo.com
El-Shazly
Samir A
SA
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002151:Calorimetry; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D007333:Insulin Resistance; D008855:Microscopy, Electron, Scanning; D051381:Rats; D012995:Solubility; D013057:Spectrum Analysis; D013696:Temperature; D013816:Thermodynamics; D013818:Thermogravimetry; D017968:Vanadium Compounds / Q000737:chemistry*; D014810:Vitamin E / Q000737:chemistry*; D014867:Water / Q000737:chemistry; D014961:X-Ray Diffraction
D001786:Blood Glucose; D006454:Hemoglobins; D007004:Hypoglycemic Agents; D017968:Vanadium Compounds; D014867:Water; D014810:Vitamin E; C034028:vanadyl sulfate; D003404:Creatinine