CCND1 G870A polymorphism and risk for head and neck cancer: a meta-analysis.
CCND1 plays a critical role in cell cycle control and may contribute to head and neck cancer. We performed a meta-analysis of eleven case-control studies that examined the association between CCND1 G870A polymorphism and head and neck cancer risk. Overall, no significant association of this polymorphism with head and neck cancer was found (for AA vs. GG: OR=0.96, 95% CI=0.59-1.58, P<0.01 for heterogeneity; for GA vs. GG: OR=1.00, 95% CI=0.74-1.35, P<0.01 for heterogeneity; for the dominant model GA/AA vs. GG: OR=0.98, 95% CI=0.69-1.39, P<0.01 for heterogeneity; for the recessive model AA vs. GG/GA: OR=0.94, 95% CI=0.66-1.33, P<0.01 for heterogeneity). In subgroup analysis by ethnicity, we also did not find any significant association in European and Asians populations. All the results were not materially altered in any genetic model after the studies which did not fulfill Hardy-Weinberg equilibrium were excluded. In conclusion, our meta-analysis strongly suggested that the CCND1 G870A polymorphism is not associated with head and neck cancer risk.
Tang
Chunbo
C
Dental Research Institute, School of Stomatology, Department of Epidemiology and Biostatistics, Nanjing Medical University, 136 Hanzhong Rd., 210029, Nanjing, China. chunbotang@gmail.com
Wang
Zhanwei
Z
Yu
Jinhua
J
Wu
Yunong
Y
Zhu
Zhijun
Z
Chen
Ning
N
D016022:Case-Control Studies; D019938:Cyclin D1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
C530104:CCND1 protein, human; D019938:Cyclin D1