title: Primary mediastinal liposarcoma, with 6 years of follow-up to autopsy, revealed histopathological features of primary and metastatic lesions.
abstract: Primary mediastinal liposarcoma was observed in a 73-year-old man. Because of tight adhesions to adjacent tissues, neither complete resection nor surgical debulking of the tumor was possible. A T-tube was inserted into the patient's trachea for severe dyspnea, and he was treated with radiotherapy and an oral peroxisome proliferator-activated receptor-gamma agonist. The patient died 6 years after the initial diagnosis. Autopsy revealed liposarcoma composed of 3 subtypes in the primary tumor: well-differentiated, dedifferentiated, and round cell components. Round cell and dedifferentiated liposarcomas were predominantly observed in the metastatic nodules.
authors.affiliation: The First Department of Medicine, Hokkaido University School of Medicine, Sapporo. satkonno@med.hokudai.ac.jp
authors.forename: Satoshi
authors.initials: S
authors.lastname: Konno
authors.forename: Satoshi
authors.initials: S
authors.lastname: Oizumi
authors.forename: Naofumi
authors.initials: N
authors.lastname: Shinagawa
authors.forename: Eiki
authors.initials: E
authors.lastname: Kikuchi
authors.forename: Jun
authors.initials: J
authors.lastname: Konishi
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Ito
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hizawa
authors.forename: Akihiro
authors.initials: A
authors.lastname: Takiyama
authors.forename: Shinya
authors.initials: S
authors.lastname: Tanaka
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nishimura
mesh_terms: D000368:Aged; D017809:Fatal Outcome; D005500:Follow-Up Studies; D006801:Humans; D008080:Liposarcoma / Q000473:pathology* / Q000532:radiotherapy / Q000556:secondary*; D008297:Male; D008479:Mediastinal Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000556:secondary*