[Expressions of interleukin 18 and prostaglandin E2 and their correlation in the synoviocytes of patients with osteoarthritis].
OBJECTIVE
To explore the expression of interleukin 18 (IL-18) and prostaglandin E2 (PGE2) and their relationship in the synoviocytes of patients with osteoarthritis (OA).


METHODS
The synovial tissues were obtained from 30 OA patients to isolate the synoviocytes for primary culture. The concentrations of IL-18 and PGE2 in the supernatants of synoviocyte culture were measured by enzyme-linked immunosorbent assay (ELISA).


RESULTS
The concentration of IL-18 averaged 51.559-/+27.614 pg/ml and PGE2 327.036-/+333.561 pg/ml in the supernatant of the synoviocytes. A significant positive correlation was noted between their expressions (r=0.863, P<0.01).


CONCLUSIONS
IL-18 may induce the production of PGE2, and their interactions they may play an important role in the pathogenesis of OA.
Wang
Feng-long
FL
Department of Spinal and Osteopathic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China. wfl-1204@163.com
Jiang
Jian-ming
JM
Wang
Fei
F
Fu
Zhao-zong
ZZ
Zhang
Zhao-fei
ZF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002478:Cells, Cultured; D015232:Dinoprostone / Q000378:metabolism*; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000378:metabolism* / Q000473:pathology; D013583:Synovial Membrane / Q000378:metabolism* / Q000473:pathology
D020382:Interleukin-18; D015232:Dinoprostone