title: In situ formation of thermosensitive PNIPAAm-based hydrogels by Michael-type addition reaction.
abstract: To investigate the possibility of in situ thermosensitive hydrogel formation via Michael-type addition reaction, we designed and prepared thiol- and vinyl-modified poly(N-isopropylacrylamide) (PNIPAAm)-based copolymers. When the solutions of these two kinds of PNIPAAm-based copolymers were mixed at physiological temperature (37 degrees C), a physical gelation resulting from the hydrophobic aggregation of PNIPAAm based copolymers and chemical cross-linking between thiol and vinyl functional groups or so-called chemical gelation occurred, resulting in the formation of a three-dimensional hydrogel. Because all the gelations were performed at a high temperature (above LCSTs of the PNIPAAm based copolymers), these in situ formed hydrogels presented heterogeneous network structures, resulting in an improved thermosensitivity in comparison with the conventional one.
authors.affiliation: Department of Chemistry, Wuhan University, Wuhan 430072, People's Republic of China.
authors.forename: Zong-Chun
authors.initials: ZC
authors.lastname: Wang
authors.forename: Xiao-Ding
authors.initials: XD
authors.lastname: Xu
authors.forename: Chang-Sheng
authors.initials: CS
authors.lastname: Chen
authors.forename: Liu
authors.initials: L
authors.lastname: Yun
authors.forename: Jin-Chun
authors.initials: JC
authors.lastname: Song
authors.forename: Xian-Zheng
authors.initials: XZ
authors.lastname: Zhang
authors.forename: Ren-Xi
authors.initials: RX
authors.lastname: Zhuo
mesh_terms: D000178:Acrylamides / Q000737:chemistry*; D000180:Acrylic Resins; D001672:Biocompatible Materials / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D006358:Hot Temperature; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D020100:Hydrogels / Q000737:chemistry*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D008422:Materials Testing; D008956:Models, Chemical; D009991:Oscillometry / Q000379:methods; D011108:Polymers / Q000737:chemistry*; D013499:Surface Properties; D013696:Temperature
chemical_list: D000178:Acrylamides; D000180:Acrylic Resins; D001672:Biocompatible Materials; D020100:Hydrogels; D011108:Polymers; C052970:poly-N-isopropylacrylamide; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate