title: Cochlear changes in presbycusis with tinnitus.
abstract: OBJECTIVE
  The pathophysiology of tinnitus is obscure and its treatment is therefore elusive. Significant progress in this field can only be achieved by determining the mechanisms of tinnitus generation, and thus, histopathologic findings of the cochlea in presbycusis with tinnitus become crucial. We revealed the histopathologic findings of the cochlea in subjects with presbycusis and tinnitus.
  
  
  METHODS
  The subjects were divided into 2 groups, presbycusis with tinnitus (tinnitus) group and presbycusis without tinnitus (control) group, with each group comprising 8 temporal bones from 8 subjects. We quantitatively analyzed the number of spiral ganglion cells, loss of cochlear inner and outer hair cells, and areas of the stria vascularis and spiral ligament.
  
  
  RESULTS
  There was a significantly greater loss of outer hair cells in the tinnitus group compared with the control group in the basal and upper middle turns. The stria vascularis was more atrophic in the tinnitus group compared with the control group in the basal turn.
  
  
  CONCLUSIONS
  Tinnitus is more common in patients with presbycusis who have more severe degeneration of outer hair cells and stria vascularis.
authors.affiliation: Department of Otolaryngology, University of Minnesota, Minneapolis, MN55455, USA.
authors.forename: Kyoichi
authors.initials: K
authors.lastname: Terao
authors.forename: Sebahattin
authors.initials: S
authors.lastname: Cureoglu
authors.forename: Patricia A
authors.initials: PA
authors.lastname: Schachern
authors.forename: Norimasa
authors.initials: N
authors.lastname: Morita
authors.forename: Shigenobu
authors.initials: S
authors.lastname: Nomiya
authors.forename: Armin F
authors.initials: AF
authors.lastname: Deroee
authors.forename: Katsumi
authors.initials: K
authors.lastname: Doi
authors.forename: Kazunori
authors.initials: K
authors.lastname: Mori
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Murata
authors.forename: Michael M
authors.initials: MM
authors.lastname: Paparella
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology*; D001299:Audiometry; D001707:Biopsy, Needle; D016022:Case-Control Studies; D003051:Cochlea / Q000473:pathology / Q000503:physiopathology*; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D006198:Hair Cells, Auditory / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011304:Presbycusis / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D011379:Prognosis; D012016:Reference Values; D018570:Risk Assessment; D013136:Spiral Ganglion / Q000473:pathology* / Q000503:physiopathology; D018709:Statistics, Nonparametric; D013316:Stria Vascularis / Q000473:pathology; D014012:Tinnitus / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*