Synthesis and evaluation of some new benzothiazole derivatives as potential antimicrobial agents.
As benzothiazole has proven to be good antimicrobial agent, a novel series of Schiff bases of benzothiazole derivatives were synthesized. Thus condensation of 5-[2-(1,3-benzothiazol-2-yl-amino) ethyl]-4-amino-3-mercapto-(4H)-1,2,4-triazole 5 with appropriate aromatic aldehydes afforded 5-[2-(1,3-benzothiazol-2-yl-amino)ethyl]-4-(arylideneamino)-3-mercapto-(4H)-1,2,4-triazoles 6a-g. Structures of the synthesized compounds were elucidated on the basis of elemental analyses and spectral data. All the synthesized compounds were screened for their antimicrobial activity.
Soni
Balram
B
Faculty of Pharmaceutical Sciences, Jodhpur National University, Narnadi, Jodhpur, Rajasthan 342 003, India. brpharma@rediffmail.com
Ranawat
Mahendra Singh
MS
Sharma
Rambabu
R
Bhandari
Anil
A
Sharma
Sanjay
S
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001391:Azo Compounds / Q000737:chemistry; D001419:Bacteria / Q000187:drug effects; D052160:Benzothiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D013882:Thiosemicarbazones / Q000737:chemistry
D000890:Anti-Infective Agents; D001391:Azo Compounds; D052160:Benzothiazoles; D013882:Thiosemicarbazones; C512188:azomethine; C005465:benzothiazole