Role of PD-1 in regulating acute infections.
While the role of PD-1 in inhibiting immunity during chronic infections is well established, its functions during acute infections are much less clear. The PD-1 pathway can dampen CD8 T cell responses during some acute infections and restrain responses by 'helpless' CD8 memory T cells. An emerging role for PD-1 in innate immunity has been revealed by recent studies showing that PD-1 can limit function of DC and macrophages as well as T cell independent B cell responses. Thus, PD-1 can influence adaptive immune responses during acute infections, though precisely how this regulation occurs is only just beginning to be appreciated.
Brown
Keturah E
KE
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Freeman
Gordon J
GJ
Wherry
E John
EJ
Sharpe
Arlene H
AH
D000208:Acute Disease; D000818:Animals; D000943:Antigens, Differentiation / Q000378:metabolism*; D002454:Cell Differentiation; D005786:Gene Expression Regulation / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D007239:Infections / Q000209:etiology / Q000276:immunology* / Q000378:metabolism; D008213:Lymphocyte Activation; D051379:Mice; D061026:Programmed Cell Death 1 Receptor; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology / Q000378:metabolism
D000943:Antigens, Differentiation; C491383:Pdcd1 protein, mouse; D061026:Programmed Cell Death 1 Receptor