The ups and downs of miR-205: identifying the roles of miR-205 in mammary gland development and breast cancer.
Recent studies have demonstrated that miR-205 has a role in both normal development and cancer, however conflicting reports on its function illustrate the complexity of its regulation and targets. Additionally, miR-205 was found to be highly expressed in stem cell-enriched populations from the mouse mammary gland, and thus may play a function in normal mammary stem cell maintenance. The role that miR-205 plays in tumor formation and metastasis is likely context-dependent as reports have indicated that it may function as either a tumor suppressor or an oncogene. The role that miR-205 plays in directing stem cell fate is still unknown.
Greene
Stephanie B
SB
Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.
Herschkowitz
Jason I
JI
Rosen
Jeffrey M
JM
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002277:Carcinoma / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D042361:Mammary Glands, Human / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism; D051379:Mice; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D008954:Models, Biological; D038081:Organogenesis / Q000235:genetics
D035683:MicroRNAs; C534425:MIR205, human