title: Synthesis of N-aryl and N-alkyl anthranilic acids via S(N)Ar reaction of unprotected 2-fluoro- and 2-methoxybenzoic acids by lithioamides.
abstract: Substitution of the fluoro or methoxy group in unprotected 2-fluoro- and 2-methoxybenzoic acids to afford N-aryl and N-alkyl anthranilic acids occurs upon reaction with lithioamides under mild conditions in the absence of a metal catalyst.
authors.affiliation: Université du Maine and CNRS, Unité de Chimie Organique Moléculaire and Macromoléculaire (UMR 6011), Faculté des Sciences, avenue Olivier Messiaen, 72085 Le Mans Cedex 9, France.
authors.forename: Mickaël
authors.initials: M
authors.lastname: Belaud-Rotureau
authors.forename: Tin Thanh
authors.initials: TT
authors.lastname: Le
authors.forename: Thi Huong Thu
authors.initials: TH
authors.lastname: Phan
authors.forename: Thi Huu
authors.initials: TH
authors.lastname: Nguyen
authors.forename: Regadia
authors.initials: R
authors.lastname: Aissaoui
authors.forename: Frédéric
authors.initials: F
authors.lastname: Gohier
authors.forename: Aïcha
authors.initials: A
authors.lastname: Derdour
authors.forename: Arnaud
authors.initials: A
authors.lastname: Nourry
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Castanet
authors.forename: Kim Phi Phung
authors.initials: KP
authors.lastname: Nguyen
authors.forename: Jacques
authors.initials: J
authors.lastname: Mortier
mesh_terms: D000577:Amides / Q000737:chemistry*; D001565:Benzoates / Q000737:chemistry*; D008094:Lithium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D062367:ortho-Aminobenzoates / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000577:Amides; D001565:Benzoates; D009942:Organometallic Compounds; D062367:ortho-Aminobenzoates; D008094:Lithium