title: Pharmacotherapy and pregnancy: highlights from the Second International Conference for Individualized Pharmacotherapy in Pregnancy.
abstract: To address provider struggles to provide evidence-based, rational drug therapy to pregnant women, a second conference was convened to highlight the current research in the field. Speakers from academic centers and institutions spoke about: the unique physiology and pathology of pregnancy; pharmacokinetic changes in pregnancy; thyroid disorders in pregnancy; pharmacogenetics in pregnancy; the role of CYP2D6 in pregnancy; treating addiction in pregnancy; the power of teratology networks to inform clinical decisions; the use of anti-depressants in pregnancy; and how to utilize computer-based modeling to aid with individualized pharmacotherapy in pregnancy. The Conference highlighted several areas of collaboration with the current Obstetrics Pharmacology Research Units Network (OPRU) and hoped to stimulate further collaboration and knowledge in the area with the common goal to improve the ability to safely and effectively use individualized pharmacotherapy in pregnancy.
authors.affiliation: Indiana University School of Medicine, PREGMED, The Indiana University Center for Pharmacogenetics and Therapeutics Research in Maternal and Child Health, Indiana, USA. dahaas@iupui.edu
authors.forename: David M
authors.initials: DM
authors.lastname: Haas
authors.forename: Mary F
authors.initials: MF
authors.lastname: Hebert
authors.forename: Offie P
authors.initials: OP
authors.lastname: Soldin
authors.forename: David A
authors.initials: DA
authors.lastname: Flockhart
authors.forename: Parvaz
authors.initials: P
authors.lastname: Madadi
authors.forename: James J
authors.initials: JJ
authors.lastname: Nocon
authors.forename: Christina D
authors.initials: CD
authors.lastname: Chambers
authors.forename: Gary D
authors.initials: GD
authors.lastname: Hankins
authors.forename: Shannon
authors.initials: S
authors.lastname: Clark
authors.forename: Katherine L
authors.initials: KL
authors.lastname: Wisner
authors.forename: Lang
authors.initials: L
authors.lastname: Li
authors.forename: Jamie L
authors.initials: JL
authors.lastname: Renbarger
authors.forename: Lee A
authors.initials: LA
authors.lastname: Learman
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D019389:Cytochrome P-450 CYP2D6 / Q000378:metabolism; D003657:Decision Making; D005260:Female; D006801:Humans; D007774:Lactation / Q000187:drug effects; D008954:Models, Biological; D010597:Pharmacogenetics; D010599:Pharmacokinetics; D057285:Precision Medicine; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011261:Pregnancy Trimester, First / Q000187:drug effects; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D018600:Teratology; D013959:Thyroid Diseases / Q000188:drug therapy
chemical_list: D015415:Biomarkers; D019389:Cytochrome P-450 CYP2D6; D017367:Selective Serotonin Reuptake Inhibitors