Non-specific effects of methylphenidate (Ritalin) on cognitive ability and decision-making of ADHD and healthy adults.
BACKGROUND
The effect of a single dose of methylphenidate (MPH) on cognitive measures and decision-making processes was assessed in a sample of adults with ADHD and in a control sample.


METHODS
Thirty-two adults satisfying DSM-IV criteria for ADHD and 26 healthy controls performed several cognitive tasks. Half of the participants received MPH prior to performing the tasks, and the other half received placebo in a randomized, double-blind manner.


RESULTS
The average digit-span test score was higher in the groups receiving MPH compared to the groups receiving placebo, while diagnosis did not have an effect upon scores. In decision-making tasks, however, MPH did not have an effect upon performance, whereas in one of the tasks the average proportion of risky choices was higher in ADHD adults compared to controls.


CONCLUSIONS
Our data therefore demonstrates that (a) MPH is capable of enhancing specific aspects of cognitive performance and (b) this enhancement is not specific to ADHD.
Agay
Nirit
N
Israel Institute of Technology, Haifa, 32000, Israel.
Yechiam
Eldad
E
Carmel
Ziv
Z
Levkovitz
Yechiel
Y
D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000523:psychology*; D003071:Cognition / Q000187:drug effects*; D003657:Decision Making / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D008875:Middle Aged; D010919:Placebos
D010919:Placebos; D008774:Methylphenidate