title: Bleeding risk for surgical dialysis procedures in children with hemolytic uremic syndrome.
abstract: Children with hemolytic uremic syndrome (HUS) frequently develop acute kidney injury (AKI) requiring renal replacement therapy (RRT). Peritoneal dialysis (PD) is commonly used. Despite high rates of thrombocytopenia, there is concern that platelet transfusions may worsen HUS by exacerbating microthrombi formation. We evaluated bleeding risk for PD catheter placement with or without central venous catheter (CVC) placement in children with HUS. Records from 1998 to 2007 were searched. Data regarding patient demographics, PD catheter placement, CVC placement, occurrence of procedure-associated bleeding, and time from insertion to removal of PD catheter were collected. Patients were stratified according to those who received and those who did not receive platelet transfusions. Seventy-three patients were identified. Twenty-two (30%) patients received platelet transfusion while 51 (70%) did not. Mean preoperative platelet counts were 37,600+/-21,900/mm(3) in patients receiving transfusions and 64,800 +/- 38,800/mm(3) in patients not receiving transfusions. Sixty-seven children (92%) also underwent CVC placement. There were no bleeding complications related to these procedures in either group. No differences in time to removal of the PD catheter were detected. Although caution and sound clinical judgment must be exercised, our findings suggest that PD catheter and CVC placement can be accomplished safely in most children with HUS, without need for platelet transfusion in spite of the associated thrombocytopenia.
authors.affiliation: Division of Pediatric Surgery, JW Riley Hospital for Children, Indiana University, 702 Barnhill Drive, Suite 2500, Indianapolis, IN 46202, USA.
authors.forename: Brent R
authors.initials: BR
authors.lastname: Weil
authors.forename: Sharon P
authors.initials: SP
authors.lastname: Andreoli
authors.forename: Deborah F
authors.initials: DF
authors.lastname: Billmire
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy*; D000293:Adolescent; D002405:Catheterization, Central Venous / Q000009:adverse effects; D002648:Child; D002675:Child, Preschool; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000150:complications*; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D007196:Indiana; D007223:Infant; D008297:Male; D018579:Patient Selection; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D017713:Platelet Transfusion / Q000009:adverse effects; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors