Endogenous neurosteroid synthesis modulates seizure frequency.
Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma-aminobutyric acid receptors and have anticonvulsant action.
Lawrence
Courtney
C
Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.
Martin
Brandon Scott
BS
Sun
Chengsan
C
Williamson
John
J
Kapur
Jaideep
J
D000818:Animals; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000379:methods; D004791:Enzyme Inhibitors / Q000009:adverse effects; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D018120:Finasteride / Q000009:adverse effects; D006062:Gonadotropins / Q000627:therapeutic use; D008094:Lithium; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors / Q000378:metabolism*; D032103:Pilocarpus; D011280:Pregnanolone / Q000627:therapeutic use; D051381:Rats
D004791:Enzyme Inhibitors; D006062:Gonadotropins; D018377:Neurotransmitter Agents; D018120:Finasteride; D008094:Lithium; D011280:Pregnanolone