Composite material of DNA and cyclodextrin-immobilized poly(ethyleneimine): Accumulation of harmful compounds from multi-component solution.
Water-soluble beta-cyclodextrin-immobilized poly(ethyleneimine) (PEICD) was synthesized by the grafting of beta-cyclodextrin to the branched poly(ethyleneimine). In an aqueous solution, this PEICD polymer could encapsulate bisphenol A, known to be a harmful compound. Additionally, the stability constant of bisphenol A to the PEICD polymer was 1.1 x 10(4)M(-1). However, the water-solubility of PEICD has been making it difficult to utilize it as an environmental material. Therefore, we prepared the DNA-PEICD composite material by mixing the double-stranded DNA and PEICD. This DNA-PEICD composite material was extremely stable in water and possessed both properties of the intercalation into the double-stranded DNA and the encapsulation into the CD cavity. As a result, this material can accumulate various harmful compounds, such as dioxin- and polychlorobiphenyl (PCB)-derivatives and bisphenol A, from a multi-component solution. Therefore, the DNA-PEICD composite material may have the potential to be used as an environmental material.
Yamada
Masanori
M
Department of Chemistry, Faculty of Science, Okayama University of Science, Ridaicho 1-1, Kita-Ku, Okayama 700-0005, Japan. myamada@chem.ous.ac.jp
Hori
Minako
M
Tabuchi
Shinya
S
D000818:Animals; D004247:DNA / Q000737:chemistry*; D004355:Drug Stability; D004785:Environmental Pollutants / Q000737:chemistry* / Q000302:isolation & purification*; D010710:Phosphates / Q000737:chemistry; D011094:Polyethyleneimine / Q000737:chemistry*; D012996:Solutions; D013050:Spectrometry, Fluorescence; D055672:Static Electricity; D014867:Water / Q000737:chemistry; D047392:beta-Cyclodextrins / Q000737:chemistry*
D004785:Environmental Pollutants; D010710:Phosphates; D012996:Solutions; D047392:beta-Cyclodextrins; D014867:Water; D011094:Polyethyleneimine; D004247:DNA; C031215:betadex