Role of nitric oxide in regulating cardiac electrophysiology.
Despite the explosion of new information on nitric oxide (NO), important questions about its role in regulating cardiac electrophysiology remain unanswered. Recent in vitro and in vivo animal studies have discovered a number of new electrophysiological properties of NO, some of which may contribute to a reduction in fatal arrhythmias induced by acute myocardial ischemia. This review summarizes the influences of NO on heart rate, atrioventricular conduction, ventricular repolarization and the development of ventricular arrhythmias during acute myocardial ischemia.
Wang
L
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School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, New South Wales, Australia.