Semisynthesis and pharmacological activities of thyroxine analogs: Development of new angiogenesis modulators.
Novel thyroxine analogs with hindered phenol, amino and carboxylic acid groups have been synthesized and the effects of the synthesized compounds on angiogenesis using the chick chorioallantoic membrane and mouse matrigel models have been tested. Pharmacological profiles revealed that thyroxine tolerates numerous modifications on the amino group and remains active. These results provide the rationale for the selection of a novel thyroxine nanoparticle precursor.
Bridoux
Alexandre
A
The Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, One Discovery Drive, Rensselaer, NY 12144, USA.
Cui
Huadong
H
Dyskin
Evgeny
E
Schmitzer
Andreea-Ruxandra
AR
Yalcin
Murat
M
Mousa
Shaker A
SA
D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D051379:Mice; D008958:Models, Molecular; D013974:Thyroxine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*
D020533:Angiogenesis Inhibitors; D013974:Thyroxine