[Abnormalities of bone metabolism in bariatric surgery].
Obesity is an ever-increasing disease in our environment, and a major risk factor for the development of other chronic diseases that increase morbidity and mortality. Bariatric surgery is an effective treatment for obesity, since it not only allows a significant and sustained loss of weight, but also an important reduction of its co-morbidities. However, this treatment is not free of complications, since along with weight loss, frequent nutritional and metabolic deficiencies have been described. These complications are particularly frequent when mixed surgical procedures with a restrictive and malabsortive component such as Roux-en-Y gastric bypass and biliopancreatic diversion are performed. The nutritional deficiencies observed include, to a greater or lesser extent, malabsorption of fat and liposoluble vitamins, as well as other micronutrients such as calcium. As a result, disorders of bone mineral metabolism with skeletal manifestations that include bone mass reduction, increased bone turnover and defective bone mineralization may develop.
Ruiz-Esquide
Virginia
V
Servicio de Reumatología, Hospital Clínico, Barcelona, España. vruizesquide@yahoo.com
Peris
Pilar
P
Gifre
Laia
L
Guañabens
Nuria
N
D050110:Bariatric Surgery / Q000009:adverse effects*; D050071:Bone Density Conservation Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D001851:Bone Diseases, Metabolic / Q000188:drug therapy / Q000209:etiology* / Q000378:metabolism; D016723:Bone Remodeling / Q000502:physiology; D002136:Calcium, Dietary / Q000493:pharmacokinetics*; D004041:Dietary Fats / Q000493:pharmacokinetics; D006801:Humans; D008286:Malabsorption Syndromes / Q000209:etiology* / Q000378:metabolism; D008903:Minerals / Q000493:pharmacokinetics; D009765:Obesity / Q000150:complications / Q000453:epidemiology / Q000378:metabolism / Q000601:surgery; D016226:Phosphorus, Dietary / Q000493:pharmacokinetics*; D011178:Postgastrectomy Syndromes / Q000209:etiology* / Q000378:metabolism; D014807:Vitamin D / Q000493:pharmacokinetics*; D014808:Vitamin D Deficiency / Q000209:etiology / Q000378:metabolism; D014815:Vitamins / Q000493:pharmacokinetics
D050071:Bone Density Conservation Agents; D002136:Calcium, Dietary; D004041:Dietary Fats; D008903:Minerals; D016226:Phosphorus, Dietary; D014815:Vitamins; D014807:Vitamin D