title: Peptoid macrocycles: making the rounds with peptidomimetic oligomers.
abstract: Macrocyclic constraints are often employed to rigidify the conformation of flexible oligomeric systems. This approach has recently been used to organize the structure of peptoid oligomers, which are peptidomimetics composed of chemically diverse N-substituted glycine monomer units. In this review, we describe advances in the synthesis and characterization of cyclic peptoids. We evaluate how the installation of covalent constraints between the oligomer termini or side chains has been effective in defining peptoid conformations. We also discuss the potential applications for this promising family of macrocyclic peptidomimetics.
authors.affiliation: Department of Chemistry, New York University, 100 Washington Square East, New York, NY 10003-6688, USA.
authors.forename: Barney
authors.initials: B
authors.lastname: Yoo
authors.forename: Sung Bin Y
authors.initials: SB
authors.lastname: Shin
authors.forename: Mia Lace
authors.initials: ML
authors.lastname: Huang
authors.forename: Kent
authors.initials: K
authors.lastname: Kirshenbaum
mesh_terms: D000595:Amino Acid Sequence; D018360:Crystallography, X-Ray; D005998:Glycine / Q000737:chemistry*; D047028:Macrocyclic Compounds / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D034444:Peptoids / Q000737:chemistry*; D011487:Protein Conformation; D013237:Stereoisomerism
chemical_list: D047028:Macrocyclic Compounds; D010456:Peptides, Cyclic; D034444:Peptoids; D005998:Glycine