Nuclear receptor Rev-erbalpha: a heme receptor that coordinates circadian rhythm and metabolism.
Nuclear receptor Rev-erbalpha (NR1D1), previously considered to be an orphan nuclear receptor, is a receptor for heme, which promotes transcriptional repression via recruitment of the NCoR-HDAC3 corepressor complex. Rev-erbalpha gene regulation is circadian, and Rev-erbalpha comprises a critical negative limb of the core circadian clock by directly repressing the expression of the positive clock component, Bmal1. Rev-erbalpha also regulates the metabolic gene pathway, thus serving as a heme sensor for coordination of circadian and metabolic pathways.
Yin
Lei
L
University of Michigan School of Medicine, Ann Arbor, Michigan, USA.
Wu
Nan
N
Lazar
Mitchell A
MA
D000818:Animals; D002467:Cell Nucleus / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D056953:Nuclear Receptor Subfamily 1, Group D, Member 1 / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D056953:Nuclear Receptor Subfamily 1, Group D, Member 1