Oxidative stress and Alzheimer's disease: dietary polyphenols as potential therapeutic agents.
Oxidative stress has been strongly implicated in the pathophysiology of neurodegenerative disorders such as Alzheimer's disease (AD). In recent years, antioxidants - especially those of dietary origin - have been suggested as possible agents useful for the prevention and treatment of AD. This article reviews the role of oxidative stress and the contribution of free radicals in the development of AD, and also discusses the use of antioxidants as a therapeutic strategy in the amelioration of this illness. The antioxidant potential of polyphenolic compounds obtained from dietary sources, such as anthocyanins from berries, catechins and theaflavins from tea, curcumin from turmeric, resveratrol from grapes and peanuts, the dihydrochalcones aspalathin and nothofagin from rooibos and the xanthone mangiferin from honeybush, are discussed in this review. The neuroprotective effects of these phytochemicals in preclinical models of AD are highlighted. Finally, innovative concepts, novel hypotheses, current challenges and future directions in the use of dietary polyphenols for the treatment of AD are discussed.
Darvesh
Altaf S
AS
Northeastern Ohio Universities Colleges of Medicine and Pharmacy, Rootstown, OH 44272, USA.
Carroll
Richard T
RT
Bishayee
Anupam
A
Geldenhuys
Werner J
WJ
Van der Schyf
Cornelis J
CJ
D000544:Alzheimer Disease / Q000503:physiopathology* / Q000628:therapy*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D005419:Flavonoids / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000503:physiopathology; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D010636:Phenols / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D059808:Polyphenols
D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D059808:Polyphenols