title: Meat, poultry and fish and risk of colorectal cancer: pooled analysis of data from the UK dietary cohort consortium.
abstract: OBJECTIVE
  Some but not all epidemiological studies have reported that high intakes of red and processed meat are associated with an increased risk of colorectal cancer. In the UK Dietary Cohort Consortium, we examined associations of meat, poultry and fish intakes with colorectal cancer risk using standardised individual dietary data pooled from seven UK prospective studies.
  
  
  METHODS
  Four- to seven-day food diaries were analysed, disaggregating the weights of meat, poultry and fish from composite foods to investigate dose-response relationships. We identified 579 cases of colorectal cancer and matched with 1,996 controls on age, sex and recruitment date. Conditional logistic regression models were used to estimate odds ratios for colorectal cancer associated with meat, poultry and fish intakes, adjusting for relevant covariables.
  
  
  RESULTS
  Disaggregated intakes were moderately low, e.g. mean red meat intakes were 38.2 g/day among male and 28.7 g/day among female controls. There was little evidence of association between the food groups examined and risk for colorectal cancer: Odds ratios (95% confidence intervals) for a 50 g/day increase were 1.01 (0.84-1.22) for red meat, 0.88 (0.68-1.15) for processed meat, 0.97 (0.84-1.12) for red and processed meat combined, 0.80 (0.65-1.00) for poultry, 0.92 (0.70-1.21) for white fish and 0.89 (0.70-1.13) for fatty fish.
  
  
  CONCLUSIONS
  This study using pooled data from prospective food diaries, among cohorts with low to moderate meat intakes, shows little evidence of association between consumption of red and processed meat and colorectal cancer risk.
authors.affiliation: Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Spencer
authors.forename: Timothy J
authors.initials: TJ
authors.lastname: Key
authors.forename: Paul N
authors.initials: PN
authors.lastname: Appleby
authors.forename: Christina C
authors.initials: CC
authors.lastname: Dahm
authors.forename: Ruth H
authors.initials: RH
authors.lastname: Keogh
authors.forename: Ian S
authors.initials: IS
authors.lastname: Fentiman
authors.forename: Tasnime
authors.initials: T
authors.lastname: Akbaraly
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Brunner
authors.forename: Victoria
authors.initials: V
authors.lastname: Burley
authors.forename: Janet E
authors.initials: JE
authors.lastname: Cade
authors.forename: Darren C
authors.initials: DC
authors.lastname: Greenwood
authors.forename: Alison M
authors.initials: AM
authors.lastname: Stephen
authors.forename: Gita
authors.initials: G
authors.lastname: Mishra
authors.forename: Diana
authors.initials: D
authors.lastname: Kuh
authors.forename: Robert
authors.initials: R
authors.lastname: Luben
authors.forename: Angela A
authors.initials: AA
authors.lastname: Mulligan
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Sheila A
authors.initials: SA
authors.lastname: Rodwell
mesh_terms: D000818:Animals; D015331:Cohort Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000209:etiology*; D015930:Diet Records; D005260:Female; D005396:Fish Products / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008461:Meat Products / Q000009:adverse effects*; D016017:Odds Ratio; D011202:Poultry Products / Q000009:adverse effects*; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology