title: Comparison of oral nonsteroidal analgesic and intrauterine local anesthetic for pain relief in uterine fractional curettage: a randomized, double-blind, placebo-controlled trial.
abstract: OBJECTIVE
  We sought to investigate the analgesic efficacy of oral dexketoprofen trometamol and intrauterine lidocaine in patients undergoing fractional curettage.
  
  
  METHODS
  A randomized, double-blind, placebo-controlled trial was conducted on 111 women. Subjects were randomly assigned into 4 groups to receive either 25 mg of dexketoprofen or similar-appearing placebo tablets and either 5 mL intrauterine 2% lidocaine or saline. The main outcome measure was the intensity of pain measured by a 10-cm visual analog scale. Pain scoring was performed prior to, during, and 30 minutes after the procedure.
  
  
  RESULTS
  No statistically significant difference was found among the mean pain scores of women during the procedure in the dexketoprofen and saline, placebo and lidocaine, and dexketoprofen and lidocaine groups. The mean pain scores in all 3 groups revealed significant reduction when compared with placebo and saline combination (P = .001).
  
  
  CONCLUSIONS
  Administration of intrauterine lidocaine or oral dexketoprofen appears to be effective in relieving fractional curettage associated pain. However, a combination of them does not work better in further reduction of pain.
authors.affiliation: Department of Obstetrics and Gynecology, Dr Lutfi Kirdar Kartal Teaching and Research Hospital, Acelya Sok. No: 12/2, Dragos/Kartal, Istanbul, Turkey. olusapi@gmail.com
authors.forename: Olus
authors.initials: O
authors.lastname: Api
authors.forename: Bahar
authors.initials: B
authors.lastname: Ergen
authors.forename: Murat
authors.initials: M
authors.lastname: Api
authors.forename: Vedat
authors.initials: V
authors.lastname: Ugurel
authors.forename: Muge Balcin
authors.initials: MB
authors.lastname: Emeksiz
authors.forename: Orhan
authors.initials: O
authors.lastname: Unal
mesh_terms: D000282:Administration, Intravaginal; D000284:Administration, Oral; D000328:Adult; D000772:Anesthesia, Local / Q000379:methods*; D000773:Anesthesia, Obstetrical / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D003475:Curettage / Q000009:adverse effects / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000031:analogs & derivatives*; D008012:Lidocaine / Q000008:administration & dosage*; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement / Q000379:methods; D018709:Statistics, Nonparametric; D014325:Tromethamine / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D014325:Tromethamine; D007660:Ketoprofen; D008012:Lidocaine; C118296:dexketoprofen trometamol