[A two-compartment phenomenological model of a dopaminergic neuron].
A two-compartment model of the dopaminergic neuron based on modified FitzHue-Nagumo oscillators for each compartment has been built. The compartments corresponded to the soma and dendrites and differed by the values of small parameters. The influence of stimuli (applied current for the somatic compartment and synaptic activation for the dendritic compartment) on the model has been studied. It has been shown that the activation of AMPA and NMDA synaptic currents lead to the generation of high-frequency bursts by the neuron. The mechanisms underlying the generation of the bursts have been investigated.
Zakharov
D G
DG
Kuznetsov
A S
AS
Nekorkin
V I
VI
D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D003712:Dendrites / Q000502:physiology*; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D008959:Models, Neurological; D013569:Synapses / Q000502:physiology*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000378:metabolism
D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D004298:Dopamine