Repair of atrial septal defect with Eisenmenger syndrome after long-term sildenafil therapy.
We report a woman with atrial septal defect and severe pulmonary hypertension with 25.0 Wood unit.m(2) of indexed total pulmonary vascular resistance. She underwent successful corrective repair of atrial septal defect after 2 years of treatment with sildenafil, and has been monitored for 4 years after repair. This case supports a "treat and repair" approach using advanced pulmonary vasodilator therapy in selected patients with inoperable severe pulmonary hypertension associated with atrial septal defect.
Kim
Young-Hwue
YH
Department of Pediatrics, College of Medicine, University of Ulsan, Seoul, Korea.
Yu
Jeong Jin
JJ
Yun
Tae-Jin
TJ
Lee
Yonghee
Y
Kim
Yong Beom
YB
Choi
Hyung Soon
HS
Jhang
Won Kyoung
WK
Shin
Hong Ju
HJ
Park
Jeong-Jun
JJ
Seo
Dong-Man
DM
Ko
Jae-Kon
JK
Park
In-Sook
IS
D000328:Adult; D006328:Cardiac Catheterization / Q000379:methods; D006348:Cardiac Surgical Procedures / Q000379:methods*; D018618:Echocardiography, Doppler, Color; D004541:Eisenmenger Complex / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006344:Heart Septal Defects, Atrial / Q000150:complications / Q000175:diagnosis* / Q000601:surgery*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008134:Long-Term Care; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines / Q000627:therapeutic use; D018570:Risk Assessment; D012720:Severity of Illness Index; D000068677:Sildenafil Citrate; D013450:Sulfones / Q000627:therapeutic use*; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000627:therapeutic use
D010879:Piperazines; D011687:Purines; D013450:Sulfones; D014665:Vasodilator Agents; D000068677:Sildenafil Citrate