title: Spontaneous bleeding into a suprasellar cavernous angioma of a neonate: case report and literature review.
abstract: BACKGROUND
  Cavernous angiomas (CA) are congenital intraparenchymal vascular malformations that contain sinusoidal spaces lined by a single-layer endothelium, separated by collagenous stroma with no intervening brain parenchyma. Despite the congenital origin of CA, they rarely present in the neonatal and prenatal period. In this paper, we present a case report of a neonatal suprasellar CA that presented with a bleed. We also present a literature review focusing on specific features of intracranial CA in the neonatal and fetal age groups.
  
  
  METHODS
  A 27-day-old neonate presented with a left eye ptosis for 2 days, followed by a generalized seizure. A head computed tomography revealed a suprasellar hematoma with intraventricular and subarachnoid extension. Brain magnetic resonance imaging revealed hemorrhages of various ages. Magnetic resonance angiography did not reveal any vascular malformation. Surgical exploration of the suprasellar mass revealed a capsulated dense hematoma. Postoperatively, the neonate was weaned of artificial ventilation over a protracted period and remained hemiparetic with signs of third nerve palsy. Pathology revealed a CA. CA presenting as a suprasellar bleed with subarachnoid and intraventricular extension is very rare especially among neonates. To the best of our knowledge, 20 cases of CA have been reported in the neonatal and fetal period in the English literature. Neonatal CA in general and suprasellar location in particular are extremely rare lesions. Neonatal/fetal CA seems to present more aggressively and have a worse prognosis compared to those presenting at a later age.
authors.affiliation: Department of Pediatric Neurosurgery, Dana Children's Hospital, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Suhas
authors.initials: S
authors.lastname: Udayakumaran
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Paraskevopoulos
authors.forename: Emanuela
authors.initials: E
authors.lastname: Cagnano
authors.forename: Jonathan
authors.initials: J
authors.lastname: Roth
authors.forename: Shlomi
authors.initials: S
authors.lastname: Constantini
mesh_terms: D001932:Brain Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D020786:Hemangioma, Cavernous, Central Nervous System / Q000150:complications* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D008297:Male