Synthesis and antimicrobial activity of new 4-heteroarylamino coumarin derivatives containing nitrogen and sulfur as heteroatoms.
Synthesis, spectral analysis and bioactivity of new coumarin derivatives are described in this paper. Eight new coumarin derivatives were synthesized in moderate to good yields by condensation of 4-chloro-3-nitrocoumarin and the corresponding heteroarylamine. The synthesized compounds were tested for their in vitro antimicrobial activity, in a standard disk diffusion assay, against thirteen strains of bacteria and three fungal strains. They have shown a wide range of activity - from one completely inactive compound to medium active ones.
Dekić
Biljana R
BR
Department of Chemistry, Faculty of Science and Mathematics, University of Pristina, Lole Ribara 29, Kosovska Mitrovica, Serbia.
Radulović
Niko S
NS
Dekić
Vidoslav S
VS
Vukićević
Rastko D
RD
Palić
Radosav M
RM
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D009584:Nitrogen / Q000737:chemistry; D013455:Sulfur / Q000737:chemistry
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D003374:Coumarins; D013455:Sulfur; D009584:Nitrogen