title: The apoptosome at high resolution.
abstract: The mechanism by which the apoptosome activates caspases during apoptosis has been controversial. Qi et al. (2010) now present a crystal structure of a funnel-shaped octameric apoptosome complex from the nematode Caenorhabditis elegans that challenges currently held assumptions about the human apoptosome structure.
authors.affiliation: Department of Pharmacology and Molecular Sciences, Johns Hopkins University, School of Medicine, Baltimore, MD 21205, USA.
authors.forename: Xinchen
authors.initials: X
authors.lastname: Teng
authors.forename: J Marie
authors.initials: JM
authors.lastname: Hardwick