[Correlation of adiponectin, monocyte chemoattractant protein-1, and endothelial function to vascular remodeling in coronary in-stent restenosis].
OBJECTIVE
To investigate the correlation between vascular remodeling index (RI) and serum adiponectin, plasma monocyte chemoattractant protein-1 (MCP-1), endothelial function and evaluate the mechanism of coronary in-stent restenosis.


METHODS
RI 6 months after percutaneous coronary intervention (PCI), serum adiponectin, plasma MCP-1 and flow-mediated dilation (FMD) before and 3 days,6 months after PCI were measured in 30 patients with and 30 without coronary in-stent restenosis.


RESULTS
Compared with patients without restenosis and those with restenosis before PCI, the patients with coronary in-stent restenosis showed significantly increased plasma MCP-1 3 days and 6 months after PCI (P<0.05) and reduced RI 6 months after PCI, serum adiponectin and FMD 3 days and 6 months after PCI (P<0.05). RI was positively correlated to serum adiponectin and FMD and inversely to MCP-1.


CONCLUSIONS
The occurrence of coronary in-stent restenosis is the result of the interrelations between multiple factors.
Wang
Zhi-bing
ZB
Department of Cardiology, Nanshan People's Hospital of Shenzhen, Shenzhen 518052, China. wang264486@hotmail.com
Liu
Jun
J
Chen
Shao-yuan
SY
Su
You-su
YS
Xie
Pei-yi
PY
Fang
Hong-cheng
HC
D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D015906:Angioplasty, Balloon, Coronary; D018932:Chemokine CCL2 / Q000097:blood*; D003327:Coronary Disease / Q000097:blood / Q000503:physiopathology / Q000628:therapy; D023903:Coronary Restenosis / Q000097:blood* / Q000209:etiology; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015607:Stents / Q000009:adverse effects*
D052242:Adiponectin; D018932:Chemokine CCL2