title: A BRCA1 promoter variant (rs11655505) and breast cancer risk.
abstract: BACKGROUND
  A study of Chinese women recently suggested that the minor allele of rs11655505 in the BRCA1 promoter (c.-2265C-->T) increases promoter activity and has a protective effect on breast cancer risk.
  
  
  METHODS
  We genotyped rs11655505 in 2912 female breast cancer cases and 2783 unaffected female controls from four Caucasian breast cancer studies.
  
  
  RESULTS
  No evidence for an association between rs11655505 and breast cancer risk was found.
  
  
  CONCLUSIONS
  Our study failed to confirm a role of rs11655505 in breast cancer risk. Larger studies are necessary to determine if there is a weak association between this SNP and breast cancer risk.
authors.affiliation: Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. paolo.radice@istitutotumori.mi.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Verderio
authors.forename: Sara
authors.initials: S
authors.lastname: Pizzamiglio
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Southey
authors.forename: Amanda B
authors.initials: AB
authors.lastname: Spurdle
authors.forename: John L
authors.initials: JL
authors.lastname: Hopper
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Chen
authors.forename: Jonathan
authors.initials: J
authors.lastname: Beesley
authors.forename: Rita K
authors.initials: RK
authors.lastname: Schmutzler
authors.forename: Christoph
authors.initials: C
authors.lastname: Engel
authors.forename: Barbara
authors.initials: B
authors.lastname: Burwinkel
authors.forename: Peter
authors.initials: P
authors.lastname: Bugert
authors.forename: Filomena
authors.initials: F
authors.lastname: Ficarazzi
authors.forename: Siranoush
authors.initials: S
authors.lastname: Manoukian
authors.forename: Monica
authors.initials: M
authors.lastname: Barile
authors.forename: Barbara
authors.initials: B
authors.lastname: Wappenschmidt
authors.forename: Georgia
authors.initials: G
authors.lastname: Chenevix-Trench
authors.forename: Paolo
authors.initials: P
authors.lastname: Radice
authors.forename: Paolo
authors.initials: P
authors.lastname: Peterlongo
mesh_terms: D019313:BRCA1 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D016015:Logistic Models; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human