[Effect of malondialdehyde on deformability of human umbilical vein endothelial cells].
In experiments on cultured endothelial cells of human umbilical vein, we found that incubation of these cells during 24 hours with malondiaidehyde (cone. 200 microM) led to over two-fold increase in the cell stiffness. These data suggest that manifold augmentation of malondialdehyde concentration during oxidative stress may be accompanied by a considerable weakening of endothelium-dependent shear stress-induced arterial dilation.
Kakorin
I D
ID
Antonova
O A
OA
Balashov
S A
SA
Mel'kumiants
A M
AM
D002478:Cells, Cultured; D042783:Endothelial Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D008315:Malondialdehyde / Q000494:pharmacology*; D018384:Oxidative Stress / Q000187:drug effects*; D014471:Umbilical Veins / Q000166:cytology / Q000378:metabolism*
D008315:Malondialdehyde