title: A one-step synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid esters from o-nitrobenzaldehydes.
abstract: A straightforward and efficient one-step procedure for the synthesis of 2,4-unsubstituted quinoline-3-carboxylic acid ethyl esters is described. The simple reductive cyclization is carried out by treating various substituted o-nitrobenzaldehydes with inexpensive, commercially available 3,3-diethoxypropionic acid ethyl ester and SnCl(2).2H(2)O in refluxing ethanol.
authors.affiliation: Johnson & Johnson Pharmaceutical Research and Development L.L.C., 3210 Merryfield Row, San Diego, California 92121, USA. hvenkate@its.jnj.com
authors.forename: Hariharan
authors.initials: H
authors.lastname: Venkatesan
authors.forename: Frances M
authors.initials: FM
authors.lastname: Hocutt
authors.forename: Todd K
authors.initials: TK
authors.lastname: Jones
authors.forename: Michael H
authors.initials: MH
authors.lastname: Rabinowitz
mesh_terms: D001547:Benzaldehydes / Q000737:chemistry*; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D004952:Esters / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001547:Benzaldehydes; D002264:Carboxylic Acids; D004952:Esters; D011804:Quinolines; C043850:2-nitrobenzaldehyde