Intracellular penetration and activity of UB-8902 in human polymorphonuclear leukocytes.
The intracellular penetration and activity of UB-8902 in human polymorphonuclear leukocytes was evaluated. Intracellular UB-8902 concentrations were 6-fold higher than extracellular levels. Uptake was rapid, reversible, saturable, and affected by external pH. UB-8902 showed intracellular activity against Staphylococcus aureus strains presenting mutations associated with fluoroquinolone resistance in the gyrA and/or grlA genes.
Ballesta
Sofía
S
Departmento de Microbiología, Facultad de Medicina, Universidad de Sevilla, Seville, Spain. mudarra@us.es
García
Isabel
I
Sánchez-Céspedez
Javier
J
Vila
Jordi
J
Pascual
Alvaro
A
D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D002939:Ciprofloxacin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D006801:Humans; D009504:Neutrophils / Q000378:metabolism*
D000890:Anti-Infective Agents; C556897:UB 8902; D002939:Ciprofloxacin