title: Endogenous neurosteroid synthesis modulates seizure frequency.
abstract: Inhibitory neurosteroids, molecules generated in glia from circulating steroid hormones and de novo from cholesterol, keep seizures in check in epileptic animals. They can enhance inhibitory transmission mediated by gamma-aminobutyric acid receptors and have anticonvulsant action.
authors.affiliation: Department of Neurology, University of Virginia, Charlottesville, Virginia, USA.
authors.forename: Courtney
authors.initials: C
authors.lastname: Lawrence
authors.forename: Brandon Scott
authors.initials: BS
authors.lastname: Martin
authors.forename: Chengsan
authors.initials: C
authors.lastname: Sun
authors.forename: John
authors.initials: J
authors.lastname: Williamson
authors.forename: Jaideep
authors.initials: J
authors.lastname: Kapur
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004569:Electroencephalography / Q000379:methods; D004791:Enzyme Inhibitors / Q000009:adverse effects; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D005260:Female; D018120:Finasteride / Q000009:adverse effects; D006062:Gonadotropins / Q000627:therapeutic use; D008094:Lithium; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors / Q000378:metabolism*; D032103:Pilocarpus; D011280:Pregnanolone / Q000627:therapeutic use; D051381:Rats
chemical_list: D004791:Enzyme Inhibitors; D006062:Gonadotropins; D018377:Neurotransmitter Agents; D018120:Finasteride; D008094:Lithium; D011280:Pregnanolone