title: Effect of individualized exercise training combined with diet restriction on inflammatory markers and IGF-1/IGFBP-3 in obese children.
abstract: OBJECTIVE
  The present study was designed to examine the possible changes in body composition, insulin-like growth factor 1 (IGF-1), insulin-like growth factor-binding protein-3 (IGFBP-3) and inflammatory markers of obese children in response to a 2-month program of exercise training combined with dietary restriction.
  
  
  METHODS
  Twenty-eight obese children (age 13.2 +/- 0.7 years, body mass index 30.9 +/- 1.3) were randomly assigned to a diet/training group or a control group and were tested two times: once before and once at the end of the experimental period. They performed a progressive cycle ergometer test at each visit. Substrate oxidation was evaluated by indirect calorimetry. Training was individualized at the point when fat oxidation was maximal (Lipox(max)).
  
  
  RESULTS
  Diet/training induced a significant decrease in body weight and body fat (after vs. before, p < 0.01). Plasma concentrations of IGF-1, IGFBP-3 and inflammatory markers were significantly decreased after the completion of the program. The diet/training program resulted in an increase in VO(2max)ACSM (24.6 +/- 2.5 to 33.1 +/- 3.1 ml/min/kg, p < 0.001) at the end of the intervention period.
  
  
  CONCLUSIONS
  These data suggest that in the presence of weight loss, exercise training improves inflammatory markers and IGF-1 and IGFBP-3 levels in obese children.
authors.affiliation: Laboratoire des adaptations Cardio-circulatoires, Respiratoires, Faculté de Médecine Ibn-El-Jazzar, Sousse,Tunisie. omar_oda @ yahoo.fr
authors.forename: Omar
authors.initials: O
authors.lastname: Ben Ounis
authors.forename: Mohamed
authors.initials: M
authors.lastname: Elloumi
authors.forename: Hassane
authors.initials: H
authors.lastname: Zouhal
authors.forename: Emna
authors.initials: E
authors.lastname: Makni
authors.forename: Myriam
authors.initials: M
authors.lastname: Denguezli
authors.forename: Mohamed
authors.initials: M
authors.lastname: Amri
authors.forename: Gérard
authors.initials: G
authors.lastname: Lac
authors.forename: Zouhair
authors.initials: Z
authors.lastname: Tabka
mesh_terms: D000293:Adolescent; D015308:Anaerobic Threshold / Q000502:physiology; D015415:Biomarkers; D001823:Body Composition; D031204:Caloric Restriction; D002648:Child; D016207:Cytokines / Q000097:blood*; D005080:Exercise Test; D005260:Female; D006801:Humans; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000378:metabolism*; D008297:Male; D009765:Obesity / Q000178:diet therapy / Q000378:metabolism* / Q000628:therapy*; D010809:Physical Fitness / Q000502:physiology*; D012885:Skinfold Thickness
chemical_list: D015415:Biomarkers; D016207:Cytokines; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I