title: [New methods for the diagnosis of implant-associated infections].
abstract: For successful treatment of prosthetic joint infection, the identification of the infecting microorganism is crucial. Cultures of synovial fluid and intraoperative periprosthetic tissue represent the standard method for diagnosing prosthetic joint infection. Rapid and accurate diagnostic tools which can detect a broad range of causing microorganisms and their antimicrobial resistance are increasingly needed. With newer diagnostic techniques, such as sonication of removed implants, microcalorimetry, molecular methods and mass spectrometry, the sensitivity has been significantly increased. In this article, we describe the conventional and newer diagnostic techniques with their advantages and potential future applications.
authors.affiliation: Service des maladies infectieuses, Département de médecine interne , CHUV, 1011 Lausanne. andrej.trampuz@chuv.ch
authors.forename: A
authors.initials: A
authors.lastname: Trampuz
authors.forename: J
authors.initials: J
authors.lastname: Steinrücken
authors.forename: M
authors.initials: M
authors.lastname: Clauss
authors.forename: A
authors.initials: A
authors.lastname: Bizzini
authors.forename: U
authors.initials: U
authors.lastname: Furustrand
authors.forename: I
authors.initials: I
authors.lastname: Uçkay
authors.forename: R
authors.initials: R
authors.lastname: Peter
authors.forename: J
authors.initials: J
authors.lastname: Bille
authors.forename: O
authors.initials: O
authors.lastname: Borens
mesh_terms: D019643:Arthroplasty, Replacement; D002151:Calorimetry / Q000379:methods; D006801:Humans; D013058:Mass Spectrometry; D008854:Microscopy, Electron; D016133:Polymerase Chain Reaction; D016459:Prosthesis-Related Infections / Q000175:diagnosis*; D014465:Ultrasonics