title: Complex links between dietary lipids, endogenous endotoxins and metabolic inflammation.
abstract: Metabolic diseases such as obesity are characterized by a subclinical inflammatory state that contributes to the development of insulin resistance and atherosclerosis. Recent reports also indicate that (i) there are alterations of the intestinal microbiota in metabolic diseases and (ii) absorption of endogenous endotoxins (namely lipopolysaccharides, LPS) can occur, particularly during the digestion of lipids. The aim of the present review is to highlight recently gained knowledge regarding the links between high fat diets, lipid digestion, intestinal microbiota and metabolic endotoxemia & inflammation.
authors.affiliation: Universite de Lyon, F-69100 Villeurbanne, France.
authors.forename: Fabienne
authors.initials: F
authors.lastname: Laugerette
authors.forename: Cécile
authors.initials: C
authors.lastname: Vors
authors.forename: Noël
authors.initials: N
authors.lastname: Peretti
authors.forename: Marie-Caroline
authors.initials: MC
authors.lastname: Michalski
mesh_terms: D000818:Animals; D004041:Dietary Fats / Q000009:adverse effects / Q000276:immunology / Q000378:metabolism; D019446:Endotoxemia / Q000209:etiology / Q000276:immunology* / Q000378:metabolism*; D004731:Endotoxins / Q000097:blood / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000276:immunology / Q000378:metabolism; D007333:Insulin Resistance; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology; D050356:Lipid Metabolism; D008659:Metabolic Diseases / Q000276:immunology / Q000378:metabolism / Q000382:microbiology; D054892:Metagenome; D051379:Mice; D009765:Obesity / Q000209:etiology / Q000276:immunology / Q000378:metabolism*; D051381:Rats
chemical_list: D004041:Dietary Fats; D004731:Endotoxins