[Important application of intestinal transporters and metabolism enzymes on gastrointestinal disposal of active ingredients of Chinese materia medica].
Oral drug bioavailability depends on gastrointestinal absorption, intestinal transporters and metabolism enzymes are the important factors in drug gastrointestinal absorption and they can also be induced or inhibited by the active ingredients of Chinese materia medica. This article presents important application of intestinal transporters and metabolism enzymes on gastrointestinal disposal of the active ingredients of Chinese materia medica, and points out the importance of research on transport and metabolism of the active ingredients of Chinese materia medica in Chinese extract and Chinese medicinal formulae.
Bi
Xiaolin
X
Nanjing University of Chinese Medicine, Nanjing 210029, China. bxl77@126.com
Du
Qiu
Q
Di
Liuqing
L
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D041981:Gastrointestinal Tract / Q000201:enzymology* / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D008419:Materia Medica / Q000378:metabolism*
D002352:Carrier Proteins; D008419:Materia Medica