Thymic stromal lymphopoietin and the pathophysiology of atopic disease.
Thymic stromal lymphopoietin (TSLP) is an IL-7-related cytokine expressed predominantly by barrier epithelial cells. TSLP is a potent activator of several cell types, including myeloid-derived dendritic cells, monocytes/macrophages and mast cells. Recent studies have revealed an important role for TSLP in the initiation and progression of allergic inflammatory diseases. In this review, we will discuss the role of TSLP in atopic diseases, as well as its function in immune homeostasis.
Miazgowicz
Michael M
MM
Immunology Program, Benaroya Research Institute, Seattle, WA, USA and Immunology Department, University of Washington School of Medicine, Seattle, WA, USA and Benaroya Research Institute at Virginia Mason, 1201 Ninth Avenue, Seattle, WA 98101, USA, Tel.: +1 206 583 6525, , mmiaz@u.washington.edu.
Headley
Mark B
MB
Larson
Ryan P
RP
Ziegler
Steven F
SF