title: Immunostimolatory activities of Vigna mungo L. extract in male Sprague-Dawley rats.
abstract: Vigna mungo L. (Fabaceae) is a popular food legume used in the traditional Indian system of medicine for the treatment of a variety of disease conditions. The objective of the study was to evaluate any immunostimulatory activities of the extract of V. mungo seeds in an animal model. The induction of any immunostimulatory effects were evaluated using measures of sheep red blood cells (SRBC)-induced humoral antibody titer, SRBC-induced delayed-type hypersensitivity (DTH), neutrophil adhesion, and in vivo phagocytosis (via the carbon clearance method) after host treatment with the extract. The results here indicated that primary and secondary antibody titers in the rats were significantly increased by treatment with the V. mungo extract as compared with those noted among rats in a control group. Increases in DTH response, the percentage (%) neutrophil adhesion, and in situ phagocytosis were also observed after treatment with the extract. We summarize that the apparent immunostimulatory effect of the V. mungo seed extract might be attributed to an augmentation of humoral and cell-mediated responses, phagocytosis, and hematopoiesis in the treated rats. The findings in this study suggest that V. mungo seed extract possesses profound immunostimulatory activities. Whether such outcomes are also evidenced by consumption of the intact seeds themselves, as is most likely to be the case with humans, remains to be determined. Nonetheless, the present study provides evidence that could help explain how the traditional use of V. mungo has been successful in the treatment of various disorders in humans.
authors.affiliation: Department of Pharmacology, L. M. College of Pharmacy, Navrangpura, Ahmadabad, Gujarat, India. dy_solanki@yahoo.co.in
authors.forename: Yogendrasinh B
authors.initials: YB
authors.lastname: Solanki
authors.forename: Sunita M
authors.initials: SM
authors.lastname: Jain
mesh_terms: D000818:Animals; D000910:Antibodies, Heterophile / Q000097:blood; D002417:Cattle; D002448:Cell Adhesion / Q000187:drug effects / Q000276:immunology; D002478:Cells, Cultured; D004912:Erythrocytes / Q000276:immunology; D007887:Fabaceae; D006968:Hypersensitivity, Delayed / Q000188:drug therapy* / Q000276:immunology; D056724:Immunity, Humoral / Q000187:drug effects; D007114:Immunization; D008297:Male; D009504:Neutrophils / Q000187:drug effects* / Q000473:pathology; D010587:Phagocytosis / Q000187:drug effects / Q000276:immunology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds; D012756:Sheep
chemical_list: D000910:Antibodies, Heterophile; D010936:Plant Extracts