title: @neurIST: infrastructure for advanced disease management through integration of heterogeneous data, computing, and complex processing services.
abstract: The increasing volume of data describing human disease processes and the growing complexity of understanding, managing, and sharing such data presents a huge challenge for clinicians and medical researchers. This paper presents the @neurIST system, which provides an infrastructure for biomedical research while aiding clinical care, by bringing together heterogeneous data and complex processing and computing services. Although @neurIST targets the investigation and treatment of cerebral aneurysms, the system's architecture is generic enough that it could be adapted to the treatment of other diseases. Innovations in @neurIST include confining the patient data pertaining to aneurysms inside a single environment that offers clinicians the tools to analyze and interpret patient data and make use of knowledge-based guidance in planning their treatment. Medical researchers gain access to a critical mass of aneurysm related data due to the system's ability to federate distributed information sources. A semantically mediated grid infrastructure ensures that both clinicians and researchers are able to seamlessly access and work on data that is distributed across multiple sites in a secure way in addition to providing computing resources on demand for performing computationally intensive simulations for treatment planning and research.
authors.affiliation: Department, of Scientific Computing, University of Vienna, Vienna 1090, Austria. sigi@par.univie.a.at
authors.forename: Siegfried
authors.initials: S
authors.lastname: Benkner
authors.forename: Antonio
authors.initials: A
authors.lastname: Arbona
authors.forename: Guntram
authors.initials: G
authors.lastname: Berti
authors.forename: Alessandro
authors.initials: A
authors.lastname: Chiarini
authors.forename: Robert
authors.initials: R
authors.lastname: Dunlop
authors.forename: Gerhard
authors.initials: G
authors.lastname: Engelbrecht
authors.forename: Alejandro F
authors.initials: AF
authors.lastname: Frangi
authors.forename: Christoph M
authors.initials: CM
authors.lastname: Friedrich
authors.forename: Susanne
authors.initials: S
authors.lastname: Hanser
authors.forename: Peer
authors.initials: P
authors.lastname: Hasselmeyer
authors.forename: Rod D
authors.initials: RD
authors.lastname: Hose
authors.forename: Jimison
authors.initials: J
authors.lastname: Iavindrasana
authors.forename: Martin
authors.initials: M
authors.lastname: Köhler
authors.forename: Luigi Lo
authors.initials: LL
authors.lastname: Iacono
authors.forename: Guy
authors.initials: G
authors.lastname: Lonsdale
authors.forename: Rodolphe
authors.initials: R
authors.lastname: Meyer
authors.forename: Bob
authors.initials: B
authors.lastname: Moore
authors.forename: Hariharan
authors.initials: H
authors.lastname: Rajasekaran
authors.forename: Paul E
authors.initials: PE
authors.lastname: Summers
authors.forename: Alexander
authors.initials: A
authors.lastname: Wöhrer
authors.forename: Steven
authors.initials: S
authors.lastname: Wood
mesh_terms: D000783:Aneurysm / Q000628:therapy; D035843:Biomedical Research; D003195:Computer Communication Networks; D016494:Computer Security; D003628:Database Management Systems; D019468:Disease Management; D005060:Europe; D006801:Humans; D033181:Information Dissemination / Q000379:methods*; D008490:Medical Informatics / Q000379:methods*