[Effect of liposuction on adipokines, inflammatory markers and insulin resistance].
OBJECTIVE
To study the effect of large-volume liposuction on adipokines, inflammatory markers and insulin resistance and its significance.


METHODS
The levels of serum adiponectin, resistin, IL-6, TNF-alpha, CRP and insulin sensitivity were measured pre- and 3 months postoperatively in 16 consecutive patients undergoing liposuction.


RESULTS
The adiponectin postoperative [(5.56 +/- 1.03) ng/ml] was significantly higher than the preoperative [(6.54 +/- 1.27) ng/ml] (P<0.05); the resistin postoperative [(6.30 +/- 3.25) pg/ml] is significantly lower than the preoperative [(5.18 +/- 2.28) pg/ml] (P<0.05); the insulin sensitivity postoperative (-3.78 +/- 0.39) significantly increased compared to the preoperative (-3.48 +/- 0.32, P<0.05); the TNF-alpha postoperative [(0.19 +/- 0.02) pg/ml] significantly increased compared to the preoperative [(0.23 +/- 0.03) pg/ml, P<0.01]; the postoperative IL-6 [(0.27 +/- 0.04) pg/ml] was similar to the preoperative [(0.31 +/- 0.06) pg/ml, P >0.05]; the postoperative CRP [(8.03 +/- 6.01) mg/L] was not significantly different with the preoperative [(7.28 +/- 6.21) mg/L, P>0.05].


CONCLUSIONS
Large-volume liposuction has good effect on insulin resistance and adipokines.
Ma
Gui-e
GE
Plastic Surgery Hospital of Chinese Academy of Medical Science, Beijing 100144, China.
Liu
Ping
P
Lei
Hua
H
Chen
Jian
J
Liu
Zhen-jun
ZJ
D054392:Adipokines / Q000097:blood*; D052242:Adiponectin / Q000097:blood; D000328:Adult; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D015850:Interleukin-6 / Q000097:blood; D015187:Lipectomy; D050356:Lipid Metabolism; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
D054392:Adipokines; D052242:Adiponectin; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha