title: Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.
abstract: We selected twenty genes from the "Top Results" list on the AlzGene database website and assessed their association with risk of developing Alzheimer's disease (AD) in a large, genome-wide association study (using 526 SNPs from 2,032 AD cases and 5,328 controls) performed in France. The APOE, CLU, PICALM, and CR1 loci were excluded, since they had already been extensively analyzed. Ten genes/loci (TFAM, SORL1, CHRNB2, SORCS1, DAPK1, MTHFR, GWA 14q32.13, BDNF, NEDD9, and CH25H) showed weak nominal association with AD risk, in line with previous studies. In the remaining ten genes/loci (TNK1, ACE, CST3, IL1B, hCG2039140, PRNP, GAB2, LOC651924, IL1A, and TF), no single nucleotide polymorphisms were associated in our dataset. Of the genes showing nominal association in our cohorts, TFAM and CHRNB2 appear particularly interesting and warrant further genetic and functional follow-up analyses.
authors.affiliation: INSERM U744, Lille, France.
authors.forename: Geoffroy
authors.initials: G
authors.lastname: Laumet
authors.forename: Vincent
authors.initials: V
authors.lastname: Chouraki
authors.forename: Benjamin
authors.initials: B
authors.lastname: Grenier-Boley
authors.forename: Vanessa
authors.initials: V
authors.lastname: Legry
authors.forename: Simon
authors.initials: S
authors.lastname: Heath
authors.forename: Diana
authors.initials: D
authors.lastname: Zelenika
authors.forename: Nathalie
authors.initials: N
authors.lastname: Fievet
authors.forename: Didier
authors.initials: D
authors.lastname: Hannequin
authors.forename: Marc
authors.initials: M
authors.lastname: Delepine
authors.forename: Florence
authors.initials: F
authors.lastname: Pasquier
authors.forename: Olivier
authors.initials: O
authors.lastname: Hanon
authors.forename: Alexis
authors.initials: A
authors.lastname: Brice
authors.forename: Jacques
authors.initials: J
authors.lastname: Epelbaum
authors.forename: Claudine
authors.initials: C
authors.lastname: Berr
authors.forename: Jean-Francois
authors.initials: JF
authors.lastname: Dartigues
authors.forename: Christophe
authors.initials: C
authors.lastname: Tzourio
authors.forename: Dominique
authors.initials: D
authors.lastname: Campion
authors.forename: Mark
authors.initials: M
authors.lastname: Lathrop
authors.forename: Lars
authors.initials: L
authors.lastname: Bertram
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Lambert
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000523:psychology; D004247:DNA / Q000235:genetics; D030541:Databases, Genetic; D005260:Female; D005602:France; D005787:Gene Frequency; D005819:Genetic Markers; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales
chemical_list: D005819:Genetic Markers; D004247:DNA