Ciné phase-contrast magnetic resonance imaging for the measurement of renal blood flow.
During critical illness, reductions in renal blood flow (RBF) are believed to be a major cause of kidney dysfunction, and therapy is often aimed at restoration of RBF. Despite this, our ability to measure RBF during critical illness has been limited by the invasiveness of the available techniques. Ciné Phase-Contrast Magnetic Resonance Imaging (CPC-MRI) represents an entirely noninvasive, contrast-free method of measuring blood flow with the potential of enabling the measurement of blood flow to major organs including the kidney. We have recently assessed the feasibility of measuring RBF by means of CPC-MRI in 2 critically ill patients with septic acute kidney injury and were able to compare such measurements to those obtained in a normal volunteer.
Prowle
John R
JR
Molan
Maurice P
MP
Hornsey
Emma
E
Bellomo
Rinaldo
R
D058186:Acute Kidney Injury / Q000503:physiopathology* / Q000628:therapy*; D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology*; D001794:Blood Pressure; D002302:Cardiac Output; D003287:Contrast Media; D016638:Critical Illness; D004562:Electrocardiography; D005260:Female; D005919:Glomerular Filtration Rate; D006321:Heart / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D012077:Renal Artery / Q000502:physiology; D012079:Renal Circulation / Q000502:physiology*; D017582:Renal Replacement Therapy; D014655:Vascular Resistance; D014661:Vasoconstriction
D003287:Contrast Media