Synthesis of C-propargylic esters of N-protected amino acids and peptides.
Recent years have seen a huge surge of interest in the application of alkyne-derived motifs for so-called "click" chemistry. Given the critical importance of amino acids in organic synthesis as well as their myriad of applications in "click" chemistry it is interesting to note that the synthesis of C-propargyl derived amino acid esters has not been particularly well served. We report a convenient, straightforward, and high-yielding synthesis of structurally diverse C-propargyl-derived N-protected amino acid esters.
Bew
Sean P
SP
School of Chemistry, University of East Anglia, Norwich, NR4 7TJ, United Kingdom. s.bew@uea.ac.uk
Hiatt-Gipson
Glyn D
GD
D000480:Alkynes / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D004952:Esters / Q000138:chemical synthesis*; D010455:Peptides / Q000737:chemistry
D000480:Alkynes; D000596:Amino Acids; D004952:Esters; D010455:Peptides