title: Trabecular bone remodelling simulation considering osteocytic response to fluid-induced shear stress.
abstract: In bone functional adaptation by remodelling, osteocytes in the lacuno-canalicular system are believed to play important roles in the mechanosensory system. Under dynamic loading, bone matrix deformation generates an interstitial fluid flow in the lacuno-canalicular system; this flow induces shear stress on the osteocytic process membrane that is known to stimulate the osteocytes. In this sense, the osteocytes behave as mechanosensors and deliver mechanical information to neighbouring cells through the intercellular communication network. In this study, bone remodelling is assumed to be regulated by the mechanical signals collected by the osteocytes. From the viewpoint of multi-scale biomechanics, we propose a mathematical model of trabecular bone remodelling that takes into account the osteocytic mechanosensory network system. Based on this model, a computational simulation of trabecular bone remodelling was conducted for a single trabecula under cyclic uniaxial loading, demonstrating functional adaptation to the applied mechanical loading as a load-bearing construct.
authors.affiliation: Department of Mechanical Engineering and Science, Kyoto University, Yoshida-hommachi, Sakyo, Kyoto 606-8501, Japan. adachi@me.kyoto-u.ac.jp
authors.forename: Taiji
authors.initials: T
authors.lastname: Adachi
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Kameo
authors.forename: Masaki
authors.initials: M
authors.lastname: Hojo
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000502:physiology*; D016723:Bone Remodeling / Q000502:physiology*; D001842:Bone and Bones / Q000166:cytology* / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D040542:Mechanotransduction, Cellular / Q000502:physiology*; D008954:Models, Biological; D010011:Osteocytes / Q000166:cytology / Q000502:physiology*; D033081:Shear Strength / Q000502:physiology