Infrared fundus autofluorescence and central serous chorioretinopathy.
OBJECTIVE
To investigate the findings of infrared fundus autofluorescence in eyes with central serous chorioretinopathy (CSC).


METHODS
This study was an observational follow-up of 83 eyes of 80 consecutive patients with CSC recruited from a hospital referral practice. Infrared autofluorescence (IR-AF) findings and those of other clinical studies, including short-wave autofluorescence (SW-AF), fundus color photography, and optical coherence tomography were assessed. The IR-AF changes that appeared during the follow-up period were recorded. The relationship between IR- and SW-AF was analyzed by comparing the categories of focal autofluorescence (granular hyper-AF, granular hypo-AF, and mixed AF). The influence of final clinical findings on final best corrected visual acuity (BCVA) was analyzed.


RESULTS
Twenty-three of 83 (27%) eyes showed granular hyper-IR-AF, whereas 53 (64%) eyes showed granular hyper-SW-AF. Most of the eyes with granular hyper-IR-AF (92%) showed granular hyper-SW-AF. On the contrary, the eyes with granular hyper-SW-AF showed various patterns of IR-AF. The deposits with hyper-IR-AF corresponding to hyper-SW-AF turned into hypo-IR-AF with hyper-SW-AF in four eyes. Final BCVA was significantly worse in eyes with granular hypo-IR-AF compared with the eyes without the findings (P = 0.035).


CONCLUSIONS
Granular hyper-IR-AF from the deposits in CSC appeared concurrently with hyper-SW-AF. Granular hyper-IR-AF changed from hyperautofluorescence to hypoautofluorescence during the follow-up period. This change of IR-AF characteristics was different from that of SW-AF. The changes are attributable to the modification of melanin in the RPE. The authors speculate that the lipofuscin-like materials contribute to the characteristic changes of IR-AF through the modification of melanin in the RPE.
Sekiryu
Tetsuju
T
Department of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, Japan. sekiryu@fmu.ac.jp
Iida
Tomohiro
T
Maruko
Ichiro
I
Saito
Kuniharu
K
Kondo
Takeshi
T
D000328:Adult; D000368:Aged; D002199:Capillary Permeability; D056833:Central Serous Chorioretinopathy / Q000175:diagnosis* / Q000378:metabolism; D005451:Fluorescein Angiography; D005453:Fluorescence; D005500:Follow-Up Studies; D005654:Fundus Oculi; D006801:Humans; D007259:Infrared Rays; D008062:Lipofuscin / Q000378:metabolism; D008543:Melanins / Q000378:metabolism; D008875:Middle Aged; D055214:Retinal Photoreceptor Cell Outer Segment / Q000378:metabolism / Q000473:pathology; D055213:Retinal Pigment Epithelium / Q000378:metabolism / Q000473:pathology; D041623:Tomography, Optical Coherence
D008062:Lipofuscin; D008543:Melanins