Histone chaperones, histone acetylation, and the fluidity of the chromogenome.
The "chromogenome" is defined as the structural and functional status of the genome at any given moment within a eukaryotic cell. This article focuses on recently uncovered relationships between histone chaperones, post-translational acetylation of histones, and modulation of the chromogenome. We emphasize those chaperones that function in a replication-independent manner, and for which three-dimensional structural information has been obtained. The emerging links between histone acetylation and chaperone function in both yeast and higher metazoans are discussed, including the importance of nucleosome-free regions. We close by posing many questions pertaining to how the coupled action of histone chaperones and acetylation influences chromogenome structure and function.
Hansen
Jeffrey C
JC
Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, Colorado 80523, USA. jeffrey.c.hansen@colostate.edu
Nyborg
Jennifer K
JK
Luger
Karolin
K
Stargell
Laurie A
LA
D000107:Acetylation; D000818:Animals; D002875:Chromosomes / Q000378:metabolism*; D016678:Genome / Q000235:genetics*; D056488:Histone Chaperones / Q000378:metabolism*; D006657:Histones / Q000378:metabolism*; D006801:Humans; D009707:Nucleosomes / Q000378:metabolism
D056488:Histone Chaperones; D006657:Histones; D009707:Nucleosomes