title: Effects of Anacardium humile leaf extracts on the development of gastrointestinal nematode larvae of sheep.
abstract: The rapid development of nematode resistance to anthelmintics has limited the success of small ruminant gastrointestinal helminthiasis control in several countries, stimulating the search for alternatives. The aim of this work was to evaluate the in vitro anthelmintic activity of Anacardium humile (Anacardiaceae) on gastrointestinal nematodes of sheep. Aqueous and ethanolic extracts of A. humile leaves were evaluated by the larval development inhibition assay at concentrations of: 187.5, 150, 100, 50, and 30 mg ml(-1); and 100, 80, 60, 40, and 20 mg ml(-1), respectively. Phytochemical analysis demonstrated the presence of tannins, flavenoids, and alkaloids in the leaves. The LD(50) was 10.14 mg ml(-1) for the aqueous extract and 23.24 mg ml(-1) for the ethanolic extract, providing evidence for the potential of this plant in the endoparasite control.
authors.affiliation: Instituto de Ciências Agrárias, Universidade Federal de Minas Gerais, Av Universitária 1000, Bairro Universitário, Montes Claros, MG 39400-006, Brazil.
authors.forename: P S
authors.initials: PS
authors.lastname: Nery
authors.forename: F A
authors.initials: FA
authors.lastname: Nogueira
authors.forename: E R
authors.initials: ER
authors.lastname: Martins
authors.forename: E R
authors.initials: ER
authors.lastname: Duarte
mesh_terms: D031021:Anacardium / Q000737:chemistry*; D000818:Animals; D000871:Anthelmintics / Q000737:chemistry / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology
chemical_list: D000871:Anthelmintics; D010936:Plant Extracts