Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.
We selected twenty genes from the "Top Results" list on the AlzGene database website and assessed their association with risk of developing Alzheimer's disease (AD) in a large, genome-wide association study (using 526 SNPs from 2,032 AD cases and 5,328 controls) performed in France. The APOE, CLU, PICALM, and CR1 loci were excluded, since they had already been extensively analyzed. Ten genes/loci (TFAM, SORL1, CHRNB2, SORCS1, DAPK1, MTHFR, GWA 14q32.13, BDNF, NEDD9, and CH25H) showed weak nominal association with AD risk, in line with previous studies. In the remaining ten genes/loci (TNK1, ACE, CST3, IL1B, hCG2039140, PRNP, GAB2, LOC651924, IL1A, and TF), no single nucleotide polymorphisms were associated in our dataset. Of the genes showing nominal association in our cohorts, TFAM and CHRNB2 appear particularly interesting and warrant further genetic and functional follow-up analyses.
Laumet
Geoffroy
G
INSERM U744, Lille, France.
Chouraki
Vincent
V
Grenier-Boley
Benjamin
B
Legry
Vanessa
V
Heath
Simon
S
Zelenika
Diana
D
Fievet
Nathalie
N
Hannequin
Didier
D
Delepine
Marc
M
Pasquier
Florence
F
Hanon
Olivier
O
Brice
Alexis
A
Epelbaum
Jacques
J
Berr
Claudine
C
Dartigues
Jean-Francois
JF
Tzourio
Christophe
C
Campion
Dominique
D
Lathrop
Mark
M
Bertram
Lars
L
Amouyel
Philippe
P
Lambert
Jean-Charles
JC
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics* / Q000523:psychology; D004247:DNA / Q000235:genetics; D030541:Databases, Genetic; D005260:Female; D005602:France; D005787:Gene Frequency; D005819:Genetic Markers; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D011569:Psychiatric Status Rating Scales
D005819:Genetic Markers; D004247:DNA