title: Significance of human papillomavirus genotyping with high-grade cervical intraepithelial neoplasia treated by a loop electrosurgical excision procedure.
abstract: OBJECTIVE
  This study was conducted to determine whether the human papillomavirus (HPV) genotype by the HPV DNA chip test (HDC) is predictive of residual or recurrent high-grade cervical intraepithelial neoplasia (CIN) 2-3 following a loop electrosurgical excision procedure (LEEP).
  
  
  METHODS
  Between January 2001-February 2007, 672 patients with CIN2-3 were treated by a LEEP and followed up with cytology, the hybrid capture II assay, and the HDC.
  
  
  RESULTS
  A total of 37 (5.5%) patients developed a recurrence, and those who developed a recurrence tested positive for the same high-risk (HR) HPV genotype before and after the LEEP. The same HR-HPV genotype by the HDC during the follow-up had a sensitivity and negative predictive value of 100% for detecting residual/recurrent disease. Persistent HPV-16 and HPV-18 were significantly associated with recurrent CIN2-3 (P < .05).
  
  
  CONCLUSIONS
  Persistent infection with the same HR-HPV genotype, especially HPV-16 and HPV-18, should be considered a risk factor for developing residual/recurrent CIN2-3.
authors.affiliation: Department of Obstetrics and Gynecology, Chonnam National University Medical School, 8 Hakdong, Gwangju, Korea.
authors.forename: Woo Dae
authors.initials: WD
authors.lastname: Kang
authors.forename: Min Jeong
authors.initials: MJ
authors.lastname: Oh
authors.forename: Seok Mo
authors.initials: SM
authors.lastname: Kim
authors.forename: Jong Hee
authors.initials: JH
authors.lastname: Nam
authors.forename: Chang Soo
authors.initials: CS
authors.lastname: Park
authors.forename: Ho Sun
authors.initials: HS
authors.lastname: Choi
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D004598:Electrosurgery; D005260:Female; D005838:Genotype; D006651:Histocytochemistry; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology* / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics*; D030361:Papillomavirus Infections / Q000473:pathology* / Q000601:surgery / Q000821:virology; D016133:Polymerase Chain Reaction; D011237:Predictive Value of Tests; D012372:ROC Curve; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery / Q000821:virology*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000473:pathology / Q000601:surgery / Q000821:virology*
chemical_list: D004279:DNA, Viral