Intracameral voriconazole injection in the treatment of fungal endophthalmitis resulting from keratitis.
OBJECTIVE
To report the therapeutic efficacy of intracameral voriconazole injection in the treatment of fungal endophthalmitis resulting from keratitis.


METHODS
Retrospective, single-institution, consecutive case series.


METHODS
Microbiologic and medical records were reviewed for patients with positive intraocular culture results or proven pathologic features for fungal organisms and clinically diagnosed fungal endophthalmitis resulting from keratitis. Ten eyes were treated with an intracameral injection of 100 microg voriconazole. Clinical characteristics, treatment, and causative organisms were analyzed.


RESULTS
Fusarium and Aspergillus were the most common causative organisms. Voriconazole was injected intracamerally from 1 to 8 times. Of the 7 patients who received 5 or more repeat injections, 6 were caused by Fusarium and 1 by Acremonium. In the remaining 3 patients who were administered 4 or fewer voriconazole injections, the causative organisms were Aspergillus and Alternaria.


CONCLUSIONS
Intracameral voriconazole injection may be an effective treatment for fungal endophthalmitis contiguously spreading from keratitis.
Shen
Ying-Cheng
YC
Department of Ophthalmology, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China. eric550131@yahoo.com.tw
Wang
Chun-Yuan
CY
Tsai
Hin-Yeung
HY
Lee
Hsin-Nung
HN
D000164:Acremonium / Q000302:isolation & purification; D000328:Adult; D000368:Aged; D000528:Alternaria / Q000302:isolation & purification; D000867:Anterior Chamber / Q000187:drug effects; D000935:Antifungal Agents / Q000008:administration & dosage*; D001230:Aspergillus / Q000302:isolation & purification; D003320:Corneal Ulcer / Q000188:drug therapy* / Q000382:microbiology; D009877:Endophthalmitis / Q000188:drug therapy* / Q000382:microbiology; D015821:Eye Infections, Fungal / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D005670:Fusarium / Q000302:isolation & purification; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000008:administration & dosage*; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage*; D014792:Visual Acuity / Q000502:physiology; D065819:Voriconazole
D000935:Antifungal Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole