Relation of resistin levels with cardiovascular risk factors, insulin resistance and inflammation in naïve diabetes obese patients.
BACKGROUND
The aim of the present study was to explore the relationship of resistin levels with cardiovascular risk factors, insulin resistance and inflammation in naïve diabetic patients.


METHODS
A population of 66 naïve diabetic patients with obesity was analyzed. A complete nutritional and biochemical evaluation was performed.


RESULTS
The mean age 56.9+/-11.6 years and the mean BMI was 37.8+/-6.3. Patients were divided in two groups by median resistin value (3.3ng/ml), group I (patients with the low values, average value 2.5+/-0.5) and group II (patients with the high values, average value 4.8+/-1.8). Patients in the group I had lower waist circumference, total cholesterol, LDL-cholesterol and C-reactive protein than patients in group II. Correlation analysis showed a significant correlation among resistin levels and the independent variables; BMI (r=0.26; p<0.05), waist circumference (r=0.38; p<0.05), fat mass (r=0.28; p<0.05), LDL-cholesterol (r=0.3; p<0.05), C-reactive protein (r=0.28; p<0.05). In the multivariate analysis, resistin concentration increase 0.024ng/ml (CI 95%: 0.006-0.42) for each mg/dl of C-reactive protein.


CONCLUSIONS
Circulating resistins are associated with C-reactive protein in an independent way in naïve diabetic patients.
de Luis
D A
DA
Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, RD-056/0013 RETICEF, University of Valladolid, C/Los Perales 16, Simancas 47130, Valladolid, Spain. Dadluis@yahoo.es
Sagrado
M Gonzalez
MG
Conde
R
R
Aller
R
R
Izaola
O
O
de la Fuente
B
B
Castrillón
J L Perez
JL
Romero
E
E
D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009765:Obesity / Q000097:blood*; D052243:Resistin / Q000097:blood*; D012307:Risk Factors
D052243:Resistin