title: Senescence-related truncation and multimerization of apolipoprotein A-I in high-density lipoprotein with an elevated level of advanced glycated end products and cholesteryl ester transfer activity.
abstract: To compare the change in lipoprotein metabolism with aging, we analyzed the lipid and protein compositions of individual lipoprotein fractions. Healthy and nonobese elderly participants (elderly group, n = 26) had a serum lipid profile within the normal range, although slightly higher than in young participants (control group, n = 18). However, the elderly group had a twofold higher serum uric acid level and triglyceride (TG):high-density lipoprotein cholesterol ratio. The elderly group had less antioxidant ability and elevated TG content in high-density lipoprotein (HDL) with enhanced cholesteryl ester transfer activity. An elevated level of advanced glycated end products in lipoproteins and fragmentation of apoA-I were present in the elderly group, with detected lower apoA-I level and more multimerized apoA-I in HDL. The protein levels of apoA-I, apoC-III, and serum amyloid A in lipoprotein-deficient serum were increased in the elderly group.
authors.affiliation: School of Biotechnology, Yeungnam University, Gyeongsan 712-749, South Korea.
authors.forename: Ki-Hoon
authors.initials: KH
authors.lastname: Park
authors.forename: Dong-Gu
authors.initials: DG
authors.lastname: Shin
authors.forename: Jae-Ryong
authors.initials: JR
authors.lastname: Kim
authors.forename: Kyung-Hyun
authors.initials: KH
authors.lastname: Cho
mesh_terms: D000368:Aged; D000375:Aging / Q000097:blood*; D000975:Antioxidants / Q000378:metabolism; D016632:Apolipoprotein A-I / Q000097:blood* / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism; D053305:Apolipoprotein C-III / Q000097:blood; D043303:Aryldialkylphosphatase / Q000097:blood; D053480:Cholesterol Ester Transfer Proteins / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood / Q000737:chemistry; D008074:Lipoproteins / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood* / Q000737:chemistry*; D008297:Male; D010316:Particle Size; D020033:Protein Isoforms / Q000097:blood; D012016:Reference Values; D000685:Serum Amyloid A Protein / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood; D055815:Young Adult
chemical_list: D000975:Antioxidants; D016632:Apolipoprotein A-I; D053305:Apolipoprotein C-III; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D017127:Glycation End Products, Advanced; D008055:Lipids; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D020033:Protein Isoforms; D000685:Serum Amyloid A Protein; D014280:Triglycerides; D014527:Uric Acid; D043303:Aryldialkylphosphatase