title: Response to sham and active gamma ventral capsulotomy in otherwise intractable obsessive-compulsive disorder.
abstract: This case regards a 34-year-old woman with severe and refractory obsessive-compulsive disorder, who was enrolled in a double-blind, randomized controlled trial of radiosurgery. She was at first submitted to a sham radiosurgical procedure, and 1 year later to an active intervention. Opposite clinical responses were observed in the follow-up of these different phases. During the sham surgery follow-up, no improvements were observed, but a remarkable amelioration was seen a few months after the active procedure. Detailed descriptions of psychopathological changes and neuroimaging findings as well as a discussion regarding the surgical technique are provided.
authors.affiliation: Department and Institute of Psychiatry, University of São Paulo Medical School, São Paulo, Brazil. fernando.sauerbronn @ gmail.com
authors.forename: F
authors.initials: F
authors.lastname: Gouvea
authors.forename: A
authors.initials: A
authors.lastname: Lopes
authors.forename: B
authors.initials: B
authors.lastname: Greenberg
authors.forename: M
authors.initials: M
authors.lastname: Canteras
authors.forename: A
authors.initials: A
authors.lastname: Taub
authors.forename: M
authors.initials: M
authors.lastname: Mathis
authors.forename: E
authors.initials: E
authors.lastname: Miguel
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D020772:Internal Capsule / Q000601:surgery*; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000601:surgery*; D010919:Placebos; D016634:Radiosurgery / Q000295:instrumentation*; D016896:Treatment Outcome
chemical_list: D010919:Placebos