Comparison of brain N-acetylaspartate levels and serum brain-derived neurotrophic factor (BDNF) levels between patients with first-episode schizophrenia psychosis and healthy controls.
BACKGROUND
N-acetylaspartate (NAA) levels and serum brain-derived neurotrophic factor (BDNF) levels in patients with first-episode schizophrenia psychosis and age- and sex-matched healthy control subjects were investigated. In addition, plasma levels of homovanillic acid (HVA) and 3-methoxy-4-hydroxyphenylglycol (MHPG) were compared between the two groups.


METHODS
Eighteen patients (nine males, nine females; age range: 13-52 years) were enrolled in the study, and 18 volunteers (nine males, nine females; age range: 15-49 years) with no current or past psychiatric history were also studied by magnetic resonance spectroscopy (MRS) as sex- and age-matched controls.


RESULTS
Levels of NAA/Cr in the left basal ganglia (p=0.0065) and parieto-occipital lobe (p=0.00498), but not in the frontal lobe, were significantly lower in patients with first-episode schizophrenia psychosis than in control subjects. No difference was observed between the serum BDNF levels of patients with first-episode schizophrenia psychosis and control subjects. In regard to the plasma levels of catecholamine metabolites, plasma MHPG, but not HVA, was significantly lower in the patients with first-episode psychosis than in control subjects. In addition, a significantly positive correlation was observed between the levels of NAA/Cr of the left basal ganglia and plasma MHPG in all subjects.


CONCLUSIONS
These results suggest that brain NAA levels in the left basal ganglia and plasma MHPG levels were significantly reduced at the first episode of schizophrenia psychosis, indicating that neurodegeneration via noradrenergic neurons might be associated with the initial progression of the disease.
Goto
N
N
Department of Psychiatry and Radiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 8078555, Japan.
Yoshimura
R
R
Kakeda
S
S
Moriya
J
J
Hayashi
K
K
Ikenouchi-Sugita
A
A
Umene-Nakano
W
W
Hori
H
H
Ueda
N
N
Korogi
Y
Y
Nakamura
J
J
D000293:Adolescent; D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D001479:Basal Ganglia / Q000737:chemistry; D001923:Brain Chemistry; D019208:Brain-Derived Neurotrophic Factor / Q000032:analysis*; D016022:Case-Control Studies; D005260:Female; D006719:Homovanillic Acid / Q000097:blood; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000097:blood; D008875:Middle Aged; D009778:Occipital Lobe / Q000737:chemistry; D010296:Parietal Lobe / Q000737:chemistry; D012559:Schizophrenia / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D055815:Young Adult
D019208:Brain-Derived Neurotrophic Factor; D001224:Aspartic Acid; D008734:Methoxyhydroxyphenylglycol; C000179:N-acetylaspartate; D006719:Homovanillic Acid