[Changes of urinary hydroxylysylpyridinoline in patients with rheumatic diseases and after operation of prostheses of the hip joint.].
Urinary hydroxylysylpyridinoline (MHP), an indicator of the catabolism of cartilage and bone was assessed in patients with various rheumatic diseases - rheumatoid arthritis (RA) and ankylosing spopndylitis (AS). It was also assessed in patients with coxarthrosis (OA) and AS who had an endopro-thesis of the hip joint and in patients with OA who had a re-operation of a loosened total endoprothesis of the hip joint. A group of healthy subjects served as controls. In all groups of patients the MHP values were elevated as compared with controls. In operated patients different values were recorded - in patients with OA the values did not change after operation, while in AS a marked rise was found. Conversely, after re-operations a drop of MHP levels was observed. Key words: hydroxylysylpyridinoline, urinary excretion, rheumatic diseases, endoprothesis of the hip.
Becvár
R
R
Revmatologický ústav, Praha.
Lichý
A
A
Macek
J
J
Adam
M
M