title: Modelling drug-eluting stents.
abstract: In this study, we consider a family of mathematical models to describe the elution of drug from polymer-coated stents into the arterial wall. Our models include the polymer layer, the media, the adventitia, a possible topcoat polymer layer and atherosclerotic plaque. We investigate the relative importance of transmural convection, diffusion and drug-dependent parameters in drug delivery and deposition. Furthermore, we investigate how the release rate from the stent can be altered and examine the resulting effect on cellular drug concentrations.
authors.affiliation: Department of Mathematics and Statistics, University of Strathclyde, 26 Richmond Street, Glasgow G1 1XH, UK. rs.smcg@maths.strath.ac.uk
authors.forename: Sean
authors.initials: S
authors.lastname: McGinty
authors.forename: Sean
authors.initials: S
authors.lastname: McKee
authors.forename: Roger M
authors.initials: RM
authors.lastname: Wadsworth
authors.forename: Christopher
authors.initials: C
authors.lastname: McCormick
mesh_terms: D002339:Carotid Arteries / Q000187:drug effects / Q000378:metabolism*; D054855:Drug-Eluting Stents; D020342:Finite Element Analysis; D006801:Humans; D008955:Models, Cardiovascular; D058226:Plaque, Atherosclerotic / Q000378:metabolism* / Q000628:therapy