title: Pyridine-based heterocycles. Synthesis of new pyrido [4',3':4,5]thieno[2,3-d]pyrimidines and related heterocycles.
abstract: The synthesis of the title compounds was achieved using ethyl 2-amino-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate (1) as starting material. The reaction of the amino ester 1 with phenylisothiocyanate in boiling ethanol afforded the thiourea derivative 5. The cyclization reactions of 5 under different reaction conditions led to different pyridothienopyrimidine derivatives. Other reactions of the latter derivatives leading to pyrido[4',3':4,5]thieno[2,3-d]triazolo[1,5-a]pyrimidines are also presented.
authors.affiliation: Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt. elkashef@aun.edu.eg
authors.forename: Hussein
authors.initials: H
authors.lastname: El-Kashef
authors.forename: Abdel-Rahman
authors.initials: AR
authors.lastname: Farghaly
authors.forename: Ahmed
authors.initials: A
authors.lastname: Al-Hazmi
authors.forename: Thierry
authors.initials: T
authors.lastname: Terme
authors.forename: Patrice
authors.initials: P
authors.lastname: Vanelle
mesh_terms: D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D011725:Pyridines / Q000138:chemical synthesis*; D011743:Pyrimidines / Q000138:chemical synthesis*
chemical_list: D006571:Heterocyclic Compounds; D011725:Pyridines; D011743:Pyrimidines