title: Chemical components from the Vietnamese soft coral Lobophytum sp.
abstract: Chromatographic separation resulted in the identification of one new squalene derivative, named lobophytene (1), three cembranoid diterpenes (2-4), and two sterols (5 and 6) from the Vietnamese marine soft coral Lobophytum sp. Their structures were identified on the basis of extensive spectroscopic data and comparison of those with reported data. Compounds 1 and 2 showed significant cytotoxic activities against lung (A549) and colon (HT-29) cell lines with IC(50) values of 8.2 and 5.6 microM for 1; 5.1 and 1.8 microM for 2, respectively.
authors.affiliation: Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghiado, Caugiay, Hanoi, Vietnam.
authors.forename: Huu Tung
authors.initials: HT
authors.lastname: Nguyen
authors.forename: Van Minh
authors.initials: VM
authors.lastname: Chau
authors.forename: Van Kiem
authors.initials: VK
authors.lastname: Phan
authors.forename: Thanh Huong
authors.initials: TH
authors.lastname: Hoang
authors.forename: Hoai Nam
authors.initials: HN
authors.lastname: Nguyen
authors.forename: Xuan Cuong
authors.initials: XC
authors.lastname: Nguyen
authors.forename: Hong Quang
authors.initials: HQ
authors.lastname: Tran
authors.forename: Xuan Nhiem
authors.initials: XN
authors.lastname: Nguyen
authors.forename: Jae-Hee
authors.initials: JH
authors.lastname: Hyun
authors.forename: Hee-Kyoung
authors.initials: HK
authors.lastname: Kang
authors.forename: Young Ho
authors.initials: YH
authors.lastname: Kim
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry* / Q000254:growth & development; D000970:Antineoplastic Agents / Q000302:isolation & purification / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D021241:Spectrometry, Mass, Electrospray Ionization; D017550:Spectroscopy, Fourier Transform Infrared; D014744:Vietnam
chemical_list: D000970:Antineoplastic Agents