Novel indole-based analogs of melatonin: synthesis and in vitro antioxidant activity studies.
The aim of this study was to synthesize and examine possible in vitro antioxidant effects of indole-based melatonin analogue compounds. As a part of our ongoing study nineteen indole hydrazide/hydrazone derivatives were synthesized, characterized and their in vitro antioxidant activity was investigated by three different assays: by evaluating their reducing effect against oxidation of a redox sensitive fluorescent probe, by examining their protective effect against H2O2-induced membrane lipid peroxidation and by determining their inhibitory effect on AAPH-induced hemolysis of human erythrocytes. The results indicated significant strong antioxidant activity for most of the compounds, when compared to melatonin.
Shirinzadeh
Hanif
H
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ankara University, Ankara, Turkey.
Eren
Burcu
B
Gurer-Orhan
Hande
H
Suzen
Sibel
S
Ozden
Seçkin
S
D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D004912:Erythrocytes / Q000187:drug effects; D006801:Humans; D006835:Hydrazones / Q000138:chemical synthesis / Q000494:pharmacology; D007211:Indoles / Q000737:chemistry*; D008550:Melatonin / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000975:Antioxidants; D006835:Hydrazones; D007211:Indoles; C030374:indole; D008550:Melatonin