Expeditious synthesis of highly substituted indolizinones via a palladium-catalyzed domino sequence.
A direct one-pot approach to polysubstituted indolizinones from tertiary propargylic alcohols using a palladium-catalyzed domino process involving aminopalladation, reductive elimination, and 1,2-shift is described.
Kim
Ikyon
I
Medicinal Chemistry Research Center, Korea Research Institute of Chemical Technology, Daejeon 305-600, Republic of Korea. ikyon@krict.re.kr
Kim
Kyungsun
K
D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D007212:Indolizines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D020005:Propanols / Q000737:chemistry*
D000480:Alkynes; D007212:Indolizines; D020005:Propanols; D010165:Palladium; C028255:propargyl alcohol