title: Donor-recipient gender and size mismatch affects graft success after kidney transplantation.
abstract: BACKGROUND
  Female recipients of male kidneys have an inferior graft survival, and patients receiving larger kidneys relative to their body size may have a graft survival advantage. Thus, graft survival may be affected by both gender and kidney size mismatches. The objective of this study was to analyze the possible confounding effect of body mass mismatch (body mass as proxy for kidney size) between female recipients of male donor kidneys.
  
  
  METHODS
  A total of 668 kidney transplantations between 1996 and 2005 at our center were studied retrospectively. Graft and patient survival were determined by Kaplan-Meier estimation. Multivariate Cox proportional analyses were performed to determine the hazards of graft loss.
  
  
  RESULTS
  There were 146 female recipients of male kidneys. Compared with all other gender combinations, this group had the lowest unadjusted graft survival (86%, 79%, and 78% vs 92%, 88%, and 86% at 1, 2, and 3 years, respectively; log-rank p = 0.01). Donor body mass index (BMI) correlated with donor kidney size (p < 0.001). Male kidneys were a risk factor of graft loss for female recipients (hazard ratio [HR] 3.45, 95% CI 1.40 to 8.51, p = 0.01), but male donors with a larger BMI relative to female recipients' significantly reduced the risk (HR 0.19, 95% CI 0.05 to 0.67, p = 0.01).
  
  
  CONCLUSIONS
  The inferior graft survival for female recipients of male donor kidneys is mitigated by male donors with a larger BMI.
authors.affiliation: Department of Surgery, Tulane University School of Medicine, New Orleans, LA 70112-2669, USA.
authors.forename: Jennifer
authors.initials: J
authors.lastname: McGee
authors.forename: Jeanette H
authors.initials: JH
authors.lastname: Magnus
authors.forename: Tareq M
authors.initials: TM
authors.lastname: Islam
authors.forename: Bernard M
authors.initials: BM
authors.lastname: Jaffe
authors.forename: Rubin
authors.initials: R
authors.lastname: Zhang
authors.forename: Sander S
authors.initials: SS
authors.lastname: Florman
authors.forename: L Lee
authors.initials: LL
authors.lastname: Hamm
authors.forename: Navyata
authors.initials: N
authors.lastname: Mruthinti
authors.forename: Karen
authors.initials: K
authors.lastname: Sullivan
authors.forename: Douglas P
authors.initials: DP
authors.lastname: Slakey
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D006085:Graft Survival; D006801:Humans; D007674:Kidney Diseases / Q000401:mortality* / Q000473:pathology / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D015996:Survival Rate; D016896:Treatment Outcome; D055815:Young Adult