Ichthyosis hystrix Curth-Macklin type in an African girl.
Ichthyosis hystrix Curth-Macklin type is a rare autosomal dominant skin disorder characterized by extensive hyperkeratosis and palmo-plantar keratoderma. It results from heterozygous frameshift mutation in keratin 1 gene (KRT1). Histological features, showing perinuclear vacuolization and binucleated cells, are similar to those of epidermolytic hyperkeratosis except for the absence of epidermolysis. The present report describes the condition in a 16-year-old African girl where available treatment was disappointing.
Yusuf
S M
SM
Dermatology Unit, Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria. shehumy@yahoo.com
Mijinyawa
M S
MS
Maiyaki
M B
MB
Mohammed
A Z
AZ
D000293:Adolescent; D005260:Female; D006801:Humans; D007057:Ichthyosis / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D015776:Keratoderma, Palmoplantar, Diffuse / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D019656:Loss of Heterozygosity; D017211:Treatment Failure