Parvovirus B 19 (PVB19) induced pure red cell aplasia (PRCA) in immunocompromised patient after liver transplantation.
Presented here is a case of human parvovirus B19 (PVB19) induced pure red-cell aplasia (PRCA) in immunocompromised patient after orthotopic liver transplantation (OLT). PVB19 is a small, single-stranded DNA whose target cell is the erythroid progenitor in bone marrow. Manifestations of PVB19 infection vary with the immunologic status of the patient, ranging from asymptomatic to severe infections and PRCA. Post-transplant PRCA is induced either by immunosuppressive agents or PVB19. In the presented case, bone marrow aspiration characterized by the absence of mature erythroid precursors and detection of PVB19 DNA in blood led to treatment with high-dose intravenous human immunoglobulins (IVIG) and subsequent recovery of erythropoiesis. Due to insufficient antibody response in immunocompromised patients, suppression of the PVB19 infection is delayed and repetitive treatments may be administrated in attempt of reversing PRCA.
Mrzljak
Anna
A
Department of Medicine, University Hospital "Merkur", Zagreb, Croatia. anna.mrzljak@gmail.com
Kardum-Skelin
Ika
I
Cvrlje
Vesna Colić
VC
Kanizaj
Tajana Filipec
TF
Sustercić
Dunja
D
Gustin
Denis
D
Kocman
Branislav
B
D001706:Biopsy; D004801:Eosine Yellowish-(YS); D006801:Humans; D016867:Immunocompromised Host; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016031:Liver Transplantation; D008297:Male; D008751:Methylene Blue; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000150:complications* / Q000276:immunology*; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D011183:Postoperative Complications / Q000276:immunology / Q000821:virology; D012010:Red-Cell Aplasia, Pure / Q000276:immunology / Q000473:pathology / Q000821:virology*; D019562:Viral Load
D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; C043260:May-Grunwald Giemsa; D008751:Methylene Blue; D004801:Eosine Yellowish-(YS)