The Heck reaction applied to 1,3- and 1,2-unsaturated derivatives, a way towards molecular complexity.
This review is an overview of the last ten years' use of the Mizoroki-Heck coupling applied to 1,2- and 1,3-dienes. Since both these systems form pi-allyl palladium intermediates in Pd(0) coupling, they show particular chemical behavior. Many examples of 1,2-dienes Heck reactions are presented. 1,2-Dienes are important substrates because of their high reactivity that makes them useful building blocks for the synthesis of biologically relevant structures.
Deagostino
Annamaria
A
Dipartimento di Chimica Generale e Chimica Organica, Università di Torino, Via Pietro Giuria, Torino, Italy. annamaria.deagostino@unito.it
Prandi
Cristina
C
Tabasso
Silvia
S
Venturello
Paolo
P
D000466:Alkadienes / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis*; D002384:Catalysis; D003500:Cyclization; D010165:Palladium / Q000737:chemistry*
D000466:Alkadienes; D001688:Biological Products; C025947:propadiene; D010165:Palladium