TAZ-mediated crosstalk between Wnt and Hippo signaling.
Previously, research addressing Hippo signaling focused on the inactivation of the proto-oncoproteins TAZ and YAP caused by the sequestration of supposedly inactive phospho-TAZ/YAP in the cytoplasm. In this issue of Developmental Cell, the Attisano laboratory now shows that cytoplasmic TAZ inhibits canonical Wnt signaling, thereby highlighting that the Hippo pathway can control other signaling cascades.
Hergovich
Alexander
A
Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.
Hemmings
Brian A
BA