title: Vincristine and intestinal pseudo-obstruction in children: report of 5 cases, literature review, and suggested management.
abstract: Intestinal pseudo-obstruction is a rare complication resulting from a variety of disorders. Symptoms include abdominal pain, nausea, vomiting, diarrhea, constipation, and malnutrition. Vincristine-related pseudo-obstruction has been reported in the literature, but its description in children and recommendations for management are lacking. A review of the literature revealed 21 reported pediatric cases of vincristine-related pseudo-obstruction. Most have, however, been attributed to a drug interaction with itraconazole, accidental vincristine overdose, or liver failure. Potential genetic causes are rarely addressed. We present here 5 cases of pseudo-obstruction related to vincristine without any identifiable predisposing factors, and a suggested algorithm for management.
authors.affiliation: Pediatric Hemato-Oncology Unit, Department of Pediatrics, Division of Clinical Pharmacology, University Hospital, Lausanne, Switzerland. manuel.diezi@chuv.ch
authors.forename: Manuel
authors.initials: M
authors.lastname: Diezi
authors.forename: Andreas
authors.initials: A
authors.lastname: Nydegger
authors.forename: Ermindo R
authors.initials: ER
authors.lastname: Di Paolo
authors.forename: Henri
authors.initials: H
authors.lastname: Kuchler
authors.forename: Maja
authors.initials: M
authors.lastname: Beck-Popovic
mesh_terms: D000293:Adolescent; D000465:Algorithms; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy*; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000139:chemically induced* / Q000628:therapy; D007680:Kidney Neoplasms / Q000188:drug therapy; D008297:Male; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D015996:Survival Rate; D016896:Treatment Outcome; D014750:Vincristine / Q000009:adverse effects*; D009396:Wilms Tumor / Q000188:drug therapy*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine