Reducing nanotube cytotoxicity using a nano-combinatorial library approach.
Carbon nanotubes (CNTs) have a great potential for applications in medicine. However, their biocompatibility and toxicity cause a great concern. Due to the large surface area of CNTs, chemical modification can dramatically alter their physiochemical properties and hence biological activity. Using a combinatorial chemistry approach, we report the synthesis of an 80-member surface-modified nanotube library. Based upon screening of this library with respect to protein-binding capacity, cytotoxicity, and immune response, we were able to select highly biocompatible nanotubes with reduced protein-binding cytotoxicity and immune response.
Zhang
Qiu
Q
School of Chemistry and Chemical Engineering, Shandong University, Shandong, P. R. China.
Zhou
Hongyu
H
Yan
Bing
B
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000633:toxicity*; D002256:Carbonic Anhydrases / Q000737:chemistry / Q000276:immunology; D002417:Cattle; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002918:Chymotrypsin / Q000737:chemistry / Q000276:immunology; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D006454:Hemoglobins / Q000737:chemistry / Q000276:immunology; D006801:Humans; D008422:Materials Testing; D037742:Nanotubes, Carbon / Q000737:chemistry / Q000633:toxicity*; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000276:immunology; D013499:Surface Properties
D001672:Biocompatible Materials; D006454:Hemoglobins; D037742:Nanotubes, Carbon; D012710:Serum Albumin, Bovine; D002918:Chymotrypsin; D002256:Carbonic Anhydrases