title: Successful oxytocin-assisted nipple aspiration in women at increased risk for breast cancer.
abstract: The high rate of interval malignancies urges for new screening methods for women at high risk for breast cancer. Nipple aspiration provides direct access to the breast tissue and its DNA, and therefore is a likely candidate, but clinical applications have been limited by the failure to obtain nipple aspiration fluid from most women. We performed oxytocin-assisted nipple aspiration in 90 women at increased risk for breast cancer based on family history or genetic test results (n = 63) and/or previous breast cancer (n = 34). Nipple fluid was obtained from 81/90 women (90%) and bilaterally in 77%. Mean discomfort rating was 0.6 (on a 0-10 scale), which was significantly lower than for mammography or MRI. These findings suggest that a new tool for biomarker detection in oxytocin-assisted nipple fluid of women at high risk for breast cancer is at hand.
authors.affiliation: Department of Pathology, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands.
authors.forename: Karijn P M
authors.initials: KP
authors.lastname: Suijkerbuijk
authors.forename: Elsken
authors.initials: E
authors.lastname: van der Wall
authors.forename: Helen
authors.initials: H
authors.lastname: Meijrink
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Pan
authors.forename: Inne H M
authors.initials: IH
authors.lastname: Borel Rinkes
authors.forename: Margreet G E M
authors.initials: MG
authors.lastname: Ausems
authors.forename: Paul J
authors.initials: PJ
authors.lastname: van Diest
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D055966:Nipple Aspirate Fluid / Q000737:chemistry*; D010120:Oxytocics; D010121:Oxytocin; D012307:Risk Factors
chemical_list: D010120:Oxytocics; D010121:Oxytocin