[Age features of the dynamics of the oscillation amplitudes of the peripheral skin blood flow during the postocclusive reactive hyperemia].
The study of age-related changes of peripheral microhemodynamics was performed by laser Doppler flowmetry in 60 healthy volunteers. To determine the reaction of the microvascular system in response to short-term ischemia an occlusion test was used. To study the dynamics of the oscillation amplitudes of the peripheral blood flow the time-amplitude analysis on the basis of continuous adaptive wavelet filtration was used. It was found that the amplitudes of the oscillation in the range of heart rate in each age group reached its maxima with a delay after the occlusion stopping, whereas in the range of respiratory rhythm such delay was not observed. It is assumed that the formation ofhyperemic response to short-term ischemia occurs due to the preferential effect of arterio-arteriolar level, and the dynamics of the amplitudes in the range of respiratory rhythm reflects the devastation ofvenular level after occlusion stop. The observed age-related decreases of the maximum amplitudes in the range of myogenic, neurogenic and endothelial rhythms in response to shortterm ischemia demonstrate an age reduction limits of the peripheral blood flow regulation by related systems.
Tikhonova
I V
IV
Tankanag
A V
AV
Chemeris
N K
NK
D000328:Adult; D000368:Aged; D000375:Aging; D001683:Biological Clocks; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology*; D007511:Ischemia; D008297:Male; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply* / Q000503:physiopathology*