A BRCA1 promoter variant (rs11655505) and breast cancer risk.
BACKGROUND
A study of Chinese women recently suggested that the minor allele of rs11655505 in the BRCA1 promoter (c.-2265C-->T) increases promoter activity and has a protective effect on breast cancer risk.


METHODS
We genotyped rs11655505 in 2912 female breast cancer cases and 2783 unaffected female controls from four Caucasian breast cancer studies.


RESULTS
No evidence for an association between rs11655505 and breast cancer risk was found.


CONCLUSIONS
Our study failed to confirm a role of rs11655505 in breast cancer risk. Larger studies are necessary to determine if there is a weak association between this SNP and breast cancer risk.
Verderio
Paolo
P
Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. paolo.radice@istitutotumori.mi.it
Pizzamiglio
Sara
S
Southey
Melissa C
MC
Spurdle
Amanda B
AB
Hopper
John L
JL
Chen
Xiaoqing
X
Beesley
Jonathan
J
Schmutzler
Rita K
RK
Engel
Christoph
C
Burwinkel
Barbara
B
Bugert
Peter
P
Ficarazzi
Filomena
F
Manoukian
Siranoush
S
Barile
Monica
M
Wappenschmidt
Barbara
B
Chenevix-Trench
Georgia
G
Radice
Paolo
P
Peterlongo
Paolo
P
D019313:BRCA1 Protein / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D019398:Genes, BRCA1; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D016015:Logistic Models; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic
D019313:BRCA1 Protein; C492913:BRCA1 protein, human