5-Hydroxy-5,6-dihydro-apo-4,4'-lycopene and methyl 5-hydroxy-5,6-dihydro-apo-4,4'-lycopenoate, novel C(30)-carotenoids produced by a mutant of marine bacterium Halobacillus halophilus [corrected].
We performed the chemical mutagenesis of Halobacillus halophilus (the producer of a C(30) carotenoid, methyl glucosyl-3,4-dehydro-apo-8'-lycopenoate) to isolate novel carotenoids that are biosynthetic intermediates of methyl glucosyl-3,4-dehydro-apo-8'-lycopenoate. As a result, we isolated two novel C(30) carotenoids, hydroxy-3,4-dehydro-apo-8'-lycopene and methyl hydroxy-3,4-dehydro-apo-8'-lycopenoate, which were biosynthesized through a novel 8'-apo C(30) pathway. These carotenoids showed antioxidative activity in the (1)O(2) suppression model.
Osawa
Ayako
A
Department of Food and Nutrition, Japan Women's University, Mejirodai, Bunkyo-ku, Tokyo, Japan.
Ishii
Yoko
Y
Sasamura
Nao
N
Morita
Marie
M
Köcher
Saskia
S
Müller
Volker
V
Sandmann
Gerhard
G
Shindo
Kazutoshi
K
D000975:Antioxidants / Q000302:isolation & purification* / Q000494:pharmacology; D001406:Bacillaceae / Q000378:metabolism*; D002338:Carotenoids / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D000077276:Lycopene; D016296:Mutagenesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D010084:Oxidation-Reduction / Q000187:drug effects
D000975:Antioxidants; C550682:hydroxy-3,4-dehydro-apo-8'-lycopene; C550683:methyl hydroxy-3,4-dehydro-apo-8'-lycopenoate; D002338:Carotenoids; D000077276:Lycopene