title: Impact of pancreatic leaks on survival following pancreaticoduodenectomy.
abstract: BACKGROUND
  Pancreatic leak following pancreaticoduodenectomy has a major impact on postoperative mortality. However, it is not clear whether pancreatic leaks affect long term survival in patients with pancreatic ductal adenocarcinoma.
  
  
  OBJECTIVE
  The aim of this study is to compare the long term outcome in patients who underwent pancreaticoduodenectomy, with and without postoperative pancreatic leak.
  
  
  METHODS
  All 133 patients who underwent a pancreaticoduodenectomy at the HepatoPancreatoBiliary Unit, Addenbrooke's Hospital, Cambridge, between June 2002 and June 2007 were identified from a prospectively held database. The study was restricted to 47 patients who had a confirmed diagnosis of pancreatic ductal adenocarcinoma.
  
  
  METHODS
  Pancreatic leak was defined as drain fluid amylase more than three times the serum level for more than 3 days post operatively.
  
  
  METHODS
  Long term survival of patients with and without leaks were compared using Kaplan-Meier curves and significance was measured using the log-rank test.
  
  
  RESULTS
  Median follow-up was 30.8 months. The median actuarial survival of all ductal adenocarcinoma patients was 19 months. Pancreatic leaks occurred in 9 patients (19.1%). There were no significant differences in the overall survival or presence of recurrence between the two groups.
  
  
  CONCLUSIONS
  Pancreatic leak following pancreaticoduodenectomy does not appear to impact on long-term outcome of patients with pancreatic ductal adenocarcinoma.
authors.affiliation: Hepato-Pancreato-Biliary Surgery, Addenbrooke's Hospital, NIHR Comprehensive Biomedical Research Centre, Cambridge, United Kingdom.
authors.forename: Fabio
authors.initials: F
authors.lastname: Ausania
authors.forename: Natalie
authors.initials: N
authors.lastname: Cook
authors.forename: Neville
authors.initials: N
authors.lastname: Jamieson
authors.forename: Emanuel
authors.initials: E
authors.lastname: Huguet
authors.forename: Asif
authors.initials: A
authors.lastname: Jah
authors.forename: Raaj
authors.initials: R
authors.lastname: Praseedom
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000401:mortality / Q000601:surgery; D000681:Amylases / Q000378:metabolism; D021441:Carcinoma, Pancreatic Ductal / Q000401:mortality* / Q000601:surgery; D002291:Carcinoma, Papillary / Q000401:mortality / Q000601:surgery; D018281:Cholangiocarcinoma / Q000401:mortality / Q000601:surgery; D016208:Databases, Factual; D004379:Duodenal Neoplasms / Q000401:mortality / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D010190:Pancreatic Neoplasms / Q000401:mortality* / Q000601:surgery; D016577:Pancreaticoduodenectomy / Q000401:mortality*; D011183:Postoperative Complications / Q000378:metabolism / Q000401:mortality*
chemical_list: D000681:Amylases