title: Modeling RNA loops using sequence homology and geometric constraints.
abstract: CONCLUSIONS
  RNA loop regions are essential structural elements of RNA molecules influencing both their structural and functional properties. We developed RLooM, a web application for homology-based modeling of RNA loops utilizing template structures extracted from the PDB. RLooM allows the insertion and replacement of loop structures of a desired sequence into an existing RNA structure. Furthermore, a comprehensive database of loops in RNA structures can be accessed through the web interface.
  
  
  METHODS
  The application was implemented in Python, MySQL and Apache. A web interface to the database and loop modeling application is freely available at http://rloom.mpimp-golm.mpg.de
  
  
  BACKGROUND
  schudoma@mpimp-golm.mpg.de; may@mpimp-golm.mpg.de; walther@mpimp-golm.mpg.de
authors.affiliation: Bioinformatics Group, Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, D-14476 Potsdam-Golm, Germany. schudoma@mpimp-golm.mpg.de
authors.forename: Christian
authors.initials: C
authors.lastname: Schudoma
authors.forename: Patrick
authors.initials: P
authors.lastname: May
authors.forename: Dirk
authors.initials: D
authors.lastname: Walther
mesh_terms: D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D012689:Sequence Homology, Nucleic Acid; D012984:Software
chemical_list: D012313:RNA