Helicobacter pylori virulence factor genotypes in children in the United States: clues about genotype and outcome relationships.
The most common Helicobacter pylori genotype among 37 U.S. children was cagA positive, vacA s1m1, and oipA "on" (n = 17, 45.9%), followed by cagA negative, vacA s2m2, and oipA "off" (n = 8, 21.6%), similar to the pattern in adults. cagA positivity was more common in blacks than in whites (i.e., 100% versus 56.5%, P = 0.032).
Yamaoka
Yoshio
Y
Michael E. DeBakey Veterans Affairs Medical Center, Houston, TX 77030, USA.
Reddy
Rita
R
Graham
David Y
DY
D000293:Adolescent; D000942:Antigens, Bacterial / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D005838:Genotype; D016481:Helicobacter Infections / Q000208:ethnology / Q000382:microbiology; D016480:Helicobacter pylori / Q000235:genetics / Q000472:pathogenicity; D006801:Humans; D044469:Racial Groups / Q000208:ethnology*; D014481:United States; D037521:Virulence Factors / Q000235:genetics*
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D037521:Virulence Factors; C080866:cagA protein, Helicobacter pylori