A new entry of amination reagents for heteroaromatic C-H bonds: copper-catalyzed direct amination of azoles with chloroamines at room temperature.
Chloroamine serves as an efficient amination reagent to the heteroaromatic C-H bond of azole under copper catalysis even at room temperature. This catalysis enables a rapid and concise construction of aminoazoles of great interest in biological and medicinal chemistry.
Kawano
Tsuyoshi
T
Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka 565-0871, Japan.
Hirano
Koji
K
Satoh
Tetsuya
T
Miura
Masahiro
M
D000586:Amination; D001393:Azoles / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D002700:Chloramines / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry*; D007202:Indicators and Reagents / Q000737:chemistry; D009584:Nitrogen / Q000737:chemistry; D013696:Temperature
D001393:Azoles; D002700:Chloramines; D007202:Indicators and Reagents; D002244:Carbon; D003300:Copper; D006859:Hydrogen; D009584:Nitrogen