title: Direct sequencing of the human microbiome readily reveals community differences.
abstract: Culture-independent studies of human microbiota by direct genomic sequencing reveal quite distinct differences among communities, indicating that improved sequencing capacity can be most wisely utilized to study more samples, rather than more sequences per sample.
authors.affiliation: Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
authors.forename: Justin
authors.initials: J
authors.lastname: Kuczynski
authors.forename: Elizabeth K
authors.initials: EK
authors.lastname: Costello
authors.forename: Diana R
authors.initials: DR
authors.lastname: Nemergut
authors.forename: Jesse
authors.initials: J
authors.lastname: Zaneveld
authors.forename: Christian L
authors.initials: CL
authors.lastname: Lauber
authors.forename: Dan
authors.initials: D
authors.lastname: Knights
authors.forename: Omry
authors.initials: O
authors.lastname: Koren
authors.forename: Noah
authors.initials: N
authors.lastname: Fierer
authors.forename: Scott T
authors.initials: ST
authors.lastname: Kelley
authors.forename: Ruth E
authors.initials: RE
authors.lastname: Ley
authors.forename: Jeffrey I
authors.initials: JI
authors.lastname: Gordon
authors.forename: Rob
authors.initials: R
authors.lastname: Knight
mesh_terms: D001419:Bacteria / Q000235:genetics*; D001483:Base Sequence; D004194:Disease; D017753:Ecosystem; D006801:Humans; D054892:Metagenome / Q000235:genetics*; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA / Q000379:methods*