Nutrient regulation of enteroendocrine cellular activity linked to cholecystokinin gene expression and secretion.
The hormone cholecystokinin is produced by the enteroendocrine I cells in the intestine, and it plays an important role in a number of physiological processes including digestion and food intake. Recent data suggest that cholecystokinin gene expression and protein secretion are regulated by macronutrients. The mechanism involves a change in intracellular levels of cAMP and Ca(+2), brought about by the activity of a number of nutrient-responsive G protein-coupled receptors, nutrient transporters, ion channels and intracellular enzymes. How these intracellular responses could lead to gene expression and protein secretion are discussed along with new directions for future investigation.
Nilaweera
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KN
Food for Health Ireland, Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland. Kanishka.nilaweera@teagasc.ie
Giblin
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L
Ross
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RP
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002766:Cholecystokinin / Q000235:genetics / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D019858:Enteroendocrine Cells / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007473:Ion Channels / Q000378:metabolism; D009747:Nutritional Physiological Phenomena
D007473:Ion Channels; D002766:Cholecystokinin; D000242:Cyclic AMP; D002118:Calcium