title: Heparin-binding protein as a biomarker of circulatory failure during severe infections: a report of three cases.
abstract: We report 3 cases of disease - leptospirosis, tropical malaria and fulminant meningococcaemia - associated with high serum concentrations of heparin-binding protein (HBP) and haemodynamic instability. Furthermore, HBP kinetics were observed for the first 3 days in survivors and were correlated with improvement in clinical condition.
authors.affiliation: Department of Infectious and Tropical Diseases, First Faculty of Medicine, Charles University in Prague and University Hospital Bulovka, Praha, Czech Republic.
authors.forename: Ondrej
authors.initials: O
authors.lastname: Beran
authors.forename: Heiko
authors.initials: H
authors.lastname: Herwald
authors.forename: Olga
authors.initials: O
authors.lastname: Dzupová
authors.forename: Pavel
authors.initials: P
authors.lastname: Chalupa
authors.forename: Michal
authors.initials: M
authors.lastname: Holub
mesh_terms: D000293:Adolescent; D000328:Adult; D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D016470:Bacteremia / Q000150:complications; D015415:Biomarkers; D001798:Blood Proteins; D002352:Carrier Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008288:Malaria / Q000150:complications; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000150:complications*; D012769:Shock / Q000175:diagnosis*
chemical_list: C062991:AZU1 protein, human; D023181:Antimicrobial Cationic Peptides; D015415:Biomarkers; D001798:Blood Proteins; D002352:Carrier Proteins