title: Implications of head and neck cancer treatment failure in the neck.
abstract: OBJECTIVE
  Study the survival of patients with cervical lymphatic squamous cell carcinoma recurrence.
  
  
  METHODS
  Review of tumor registry database.
  
  
  METHODS
  Academic health science center.
  
  
  METHODS
  Forty-seven isolated neck recurrence patients identified from 224 recurrences from a total of 1291 patients treated between 1998 and 2007. The main outcome measurements were neck lymph nodal recurrence, treatment-specific survival, and overall survival.
  
  
  RESULTS
  A total of 47 patients had neck recurrence; 10 of the neck recurrence patients (21.3%) had regional disease (N+) at initial presentation. Median survival for patients with neck recurrence was 14.7 months (95% confidence interval [CI] 8.6-18.1 mo), and five-year survival for this group was five percent (95% CI 0%-30%). Neck dissection salvage therapy for neck recurrence resulted in the best survival.
  
  
  CONCLUSIONS
  Neck dissection as a salvage therapy for neck recurrence resulted in the best survival, and there was no survival benefit in terms of whether a patient had a neck dissection or not as his or her initial therapy.
authors.affiliation: University of Arkansas, College of Medicine, Little Rock, AR 72205, USA.
authors.forename: David R
authors.initials: DR
authors.lastname: Deschamps
authors.forename: Horace J
authors.initials: HJ
authors.lastname: Spencer
authors.forename: Mimi S
authors.initials: MS
authors.lastname: Kokoska
authors.forename: Paul M
authors.initials: PM
authors.lastname: Spring
authors.forename: Emre A
authors.initials: EA
authors.lastname: Vural
authors.forename: Brendan C
authors.initials: BC
authors.lastname: Stack
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local; D016879:Salvage Therapy; D017211:Treatment Failure