Seven new vernocuminosides from the stem bark of Vernonia cumingiana Benth.
Seven new stigmastane-type steroidal glycosides, vernocuminosides H-N, have been isolated from the stem bark of Vernonia cumingiana Benth. The structures of these compounds were determined by NMR spectrometric methods including HSQC, HMBC, (1)H-(1)H COSY, and NOE, as well as circular dichroism experiments. Anti-inflammatory activities of vernocuminosides I and K-N were determined.
Liu
Jing
J
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education & Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Xiannongtan Street, Beijing, People's Republic of China.
Ma
Shuanggang
S
Yu
Shishan
S
Lv
Haining
H
Li
Yong
Y
Wu
Xianfu
X
Liu
Yuanyan
Y
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D024301:Plant Bark / Q000737:chemistry*; D051381:Rats; D035741:Vernonia / Q000737:chemistry*
D000893:Anti-Inflammatory Agents; D006027:Glycosides