title: Development of a multi-scale finite element model of the osteoporotic lumbar vertebral body for the investigation of apparent level vertebra mechanics and micro-level trabecular mechanics.
abstract: Osteoporotic spinal fractures are a major concern in ageing Western societies. This study develops a multi-scale finite element (FE) model of the osteoporotic lumbar vertebral body to study the mechanics of vertebral compression fracture at both the apparent (whole vertebral body) and micro-structural (internal trabecular bone core) levels. Model predictions were verified against experimental data, and found to provide a reasonably good representation of the mechanics of the osteoporotic vertebral body. This novel modelling methodology will allow detailed investigation of how trabecular bone loss in osteoporosis affects vertebral stiffness and strength in the lumbar spine.
authors.affiliation: Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Australia.
authors.forename: K
authors.initials: K
authors.lastname: McDonald
authors.forename: J
authors.initials: J
authors.lastname: Little
authors.forename: M
authors.initials: M
authors.lastname: Pearcy
authors.forename: C
authors.initials: C
authors.lastname: Adam
mesh_terms: D000368:Aged; D001696:Biomechanical Phenomena; D005260:Female; D020342:Finite Element Analysis; D050723:Fractures, Bone / Q000150:complications / Q000503:physiopathology; D006801:Humans; D008159:Lumbar Vertebrae / Q000293:injuries / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010024:Osteoporosis / Q000150:complications / Q000503:physiopathology*; D013314:Stress, Mechanical