Fetal exposure to gestational diabetes contributes to subsequent adult metabolic syndrome.
Obesity and diabetes have become globally epidemic. The cause of this unprecedented rise in obesity is multifactorial, with inactivity, excessive calorie intake, and genetic factors implicated. More recent data indicate that exposure to diabetes during pregnancy increases the risk of childhood and adult obesity, diabetes, and cardiovascular disease. Evidence derived from recent randomized controlled trials indicates that gestational diabetes mellitus (GDM) treatment reduces newborn obesity and therefore may contribute to reducing the global prevalence of obesity and metabolic syndrome. Current evidence detailing increases in global prevalence of obesity was reviewed together with data evaluating the effectiveness of treatment of GDM. Development of new protocols for diagnosis and treatment of GDM may reduce population obesity and cardiovascular disease.
Moore
Thomas R
TR
Department of Reproductive Medicine, University of California San Diego, School of Medicine, San Diego, CA, USA.
D000328:Adult; D016640:Diabetes, Gestational / Q000453:epidemiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D024821:Metabolic Syndrome / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism; D009765:Obesity / Q000453:epidemiology* / Q000209:etiology / Q000378:metabolism; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology* / Q000378:metabolism*; D015995:Prevalence