Tributyltin hydride-mediated radical cyclisation reactions: efficient construction of multiply substituted cyclopentanes.
The nBu(3)SnH-mediated cyclisation reactions of allylic-allylic alkylation products of alpha,alpha-dicyanoalkenes and Morita-Baylis-Hillman (MBH) carbonates of methyl vinyl ketone (MVK) have been investigated. Cyclopentane derivatives bearing multiple substituents were efficiently prepared with moderate to excellent diastereoselectivity.
Lei
Jie
J
State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.
Cui
Hai-Lei
HL
Li
Rui
R
Wu
Li
L
Ding
Zheng-Yu
ZY
Chen
Ying-Chun
YC
D002384:Catalysis; D003500:Cyclization; D003517:Cyclopentanes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014220:Trialkyltin Compounds / Q000737:chemistry*
D003517:Cyclopentanes; D014220:Trialkyltin Compounds; C011559:tributyltin