title: In vitro antimicrobial, antioxidant, and antispasmodic activities and the composition of the essential oil of Origanum acutidens (Hand.-Mazz.) Ietswaart.
abstract: The radical scavenging, antimicrobial, and antispasmodic activities and the composition of Origanum acutidens (Hand.-Mazz.) Ietswaart (Order Labiatte) essential oil were evaluated in vitro. Gas chromatography/mass spectrometry analysis of the oil resulted in the identification of 20 compounds, representing 93.61% of the oil; carvacrol (65%) was the main component. The sample was also subjected to a screening for antioxidant activity by using the 1,1-diphenyl-2-picrylhydrazyl and beta-carotene/linoleic acid assays. The essential oil exhibited strong antioxidant activity. Using the agar disk diffusion method, antimicrobial activities of the essential oils were determined for nine microorganisms; antimicrobial activity was shown against eight of them. O. acutidens oil exhibited spontaneous contractions in rat ileum at the 100% level at 0.1 mg/mL level.
authors.affiliation: Vocational School of Health Services, Cumhuriyet University, Sivas, Turkey. igoze58@mynet.com
authors.forename: Ismihan
authors.initials: I
authors.lastname: Goze
authors.forename: Ahmet
authors.initials: A
authors.lastname: Alim
authors.forename: Senay Akkus
authors.initials: SA
authors.lastname: Cetinus
authors.forename: Ali
authors.initials: A
authors.lastname: Cetin
authors.forename: Nedim
authors.initials: N
authors.lastname: Durmus
authors.forename: Ahmet Turan
authors.initials: AT
authors.lastname: Atas
authors.forename: Nilufer
authors.initials: N
authors.lastname: Vural
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000032:analysis / Q000494:pharmacology*; D000975:Antioxidants / Q000032:analysis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009822:Oils, Volatile / Q000032:analysis / Q000494:pharmacology*; D031341:Origanum / Q000737:chemistry*; D010276:Parasympatholytics / Q000032:analysis / Q000494:pharmacology*; D010938:Plant Oils / Q000032:analysis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000890:Anti-Infective Agents; D000975:Antioxidants; D009822:Oils, Volatile; D010276:Parasympatholytics; D010938:Plant Oils