title: Synthesis and biological evaluation of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives via click chemistry approach.
abstract: Synthesis of new 2-chloro-3-((4-phenyl-1H-1,2,3-triazol-1-yl)methyl)quinoline derivatives (4a-h) using 1,3-dipolar cycloaddition (click chemistry) reaction of 3-(azidomethyl)-2-chloro-quinoline derivatives (3a-h) with phenyl acetylene in the presence of Cu(I) catalyst has been achieved in very high yield. These molecules were evaluated in vitro for their antifungal and antibacterial activity. Most of the compounds exhibited significant antifungal and antibacterial activity against all the tested strains.
authors.affiliation: Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004, Maharashtra, India.
authors.forename: Amol H
authors.initials: AH
authors.lastname: Kategaonkar
authors.forename: Pravin V
authors.initials: PV
authors.lastname: Shinde
authors.forename: Atul H
authors.initials: AH
authors.lastname: Kategaonkar
authors.forename: Sharad K
authors.initials: SK
authors.lastname: Pasale
authors.forename: Bapurao B
authors.initials: BB
authors.lastname: Shingate
authors.forename: Murlidhar S
authors.initials: MS
authors.lastname: Shingare
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D011804:Quinolines; C037219:quinoline