Outcomes of a combined antegrade and retrograde approach for dilatation of radiation-induced esophageal strictures (with video).
BACKGROUND
Treatment of head, neck, and esophageal cancers with radiation therapy can lead to esophageal strictures. In some cases, these can progress to complete esophageal obstruction, precluding typical antegrade endoscopic dilation.


OBJECTIVE
The aim of this study was to review our experience with a combined antegrade/retrograde technique for dilation of complete esophageal strictures.


METHODS
Case series.


METHODS
Tertiary-care referral center.


METHODS
Twelve patients with complete esophageal radiation-induced strictures.


METHODS
In collaboration with otolaryngologists who performed direct antegrade esophagoscopy, retrograde endoscopy via gastrostomy was simultaneously performed. While visualizing the stricture from both sides and transilluminating, it was recannulated with use of a biliary or spring-tipped guidewire, and then dilated.


METHODS
Dilation method, complications, and postdilation oral intake.


RESULTS
Combined antegrade and retrograde dilation was technically possible in 10 of the 12 patients (83%). Two cases were unsuccessful due to an inability to achieve transillumination. The only significant complication was a contained esophageal perforation that was managed nonoperatively. The mean number of repeat dilations was 7 (range, 1-22); none were complicated by perforation. Esophageal patency allowing at least some oral intake and tolerance of secretions was ultimately successful in 8 patients (67%).


CONCLUSIONS
Retrospective, single center.


CONCLUSIONS
A combined antegrade/retrograde approach for dilation of complete esophageal radiation-induced strictures in collaboration with colleagues from otolaryngology is a viable treatment option. The procedure is technically feasible, effective, and well tolerated, although there may be an increased risk of esophageal perforation. This strategy may obviate a more invasive surgical approach.
Dellon
Evan S
ES
Center for Esophageal Diseases and Swallowing , Division of Gastroenterology and Hepatology, Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. edellon@med.unc.edu
Cullen
Nicole R
NR
Madanick
Ryan D
RD
Buckmire
Robert A
RA
Grimm
Ian S
IS
Weissler
Mark C
MC
Couch
Marion E
ME
Shaheen
Nicholas J
NJ
D000328:Adult; D000368:Aged; D002404:Catheterization / Q000379:methods*; D004938:Esophageal Neoplasms / Q000532:radiotherapy*; D004940:Esophageal Stenosis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D004945:Esophagoscopy / Q000379:methods*; D004947:Esophagus / Q000473:pathology / Q000528:radiation effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D012189:Retrospective Studies; D016896:Treatment Outcome; D014741:Video Recording