title: Parvovirus B 19 (PVB19) induced pure red cell aplasia (PRCA) in immunocompromised patient after liver transplantation.
abstract: Presented here is a case of human parvovirus B19 (PVB19) induced pure red-cell aplasia (PRCA) in immunocompromised patient after orthotopic liver transplantation (OLT). PVB19 is a small, single-stranded DNA whose target cell is the erythroid progenitor in bone marrow. Manifestations of PVB19 infection vary with the immunologic status of the patient, ranging from asymptomatic to severe infections and PRCA. Post-transplant PRCA is induced either by immunosuppressive agents or PVB19. In the presented case, bone marrow aspiration characterized by the absence of mature erythroid precursors and detection of PVB19 DNA in blood led to treatment with high-dose intravenous human immunoglobulins (IVIG) and subsequent recovery of erythropoiesis. Due to insufficient antibody response in immunocompromised patients, suppression of the PVB19 infection is delayed and repetitive treatments may be administrated in attempt of reversing PRCA.
authors.affiliation: Department of Medicine, University Hospital "Merkur", Zagreb, Croatia. anna.mrzljak@gmail.com
authors.forename: Anna
authors.initials: A
authors.lastname: Mrzljak
authors.forename: Ika
authors.initials: I
authors.lastname: Kardum-Skelin
authors.forename: Vesna Colić
authors.initials: VC
authors.lastname: Cvrlje
authors.forename: Tajana Filipec
authors.initials: TF
authors.lastname: Kanizaj
authors.forename: Dunja
authors.initials: D
authors.lastname: Sustercić
authors.forename: Denis
authors.initials: D
authors.lastname: Gustin
authors.forename: Branislav
authors.initials: B
authors.lastname: Kocman
mesh_terms: D001706:Biopsy; D004801:Eosine Yellowish-(YS); D006801:Humans; D016867:Immunocompromised Host; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016031:Liver Transplantation; D008297:Male; D008751:Methylene Blue; D008875:Middle Aged; D010322:Parvoviridae Infections / Q000150:complications* / Q000276:immunology*; D016732:Parvovirus B19, Human / Q000302:isolation & purification*; D011183:Postoperative Complications / Q000276:immunology / Q000821:virology; D012010:Red-Cell Aplasia, Pure / Q000276:immunology / Q000473:pathology / Q000821:virology*; D019562:Viral Load
chemical_list: D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; C043260:May-Grunwald Giemsa; D008751:Methylene Blue; D004801:Eosine Yellowish-(YS)