Glucose-triggered drug delivery from borate mediated layer-by-layer self-assembly.
In this study, we report a novel approach for glucose-triggered anticancer drug delivery from the self-assembly of neutral poly(vinyl alcohol) (PVA) and chitosan. In the present study, we have fabricated multilayer thin film of PVA-borate and chitosan on colloidal particle (MF particle) and monitored the layer-by-layer growth using Zeta potential measurements. Formation of multilayer membrane on MF particle has been further characterized with transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM). Subsequently, disintegration of multilayer thin film and microcapsules was observed in presence of glucose. We investigated the disassembly of PVA-borate and chitosan self-assembly under CLSM and atomic force microscopy. These results suggest that this multilayer thin film is very efficient for encapsulation and release of DOX molecules above certain concentration of glucose (25 mM). This glucose-sensitive self-assembly is relevant for the application of anticancer therapeutic drug delivery.
Manna
Uttam
U
Solid State and Structural Chemistry Unit, Indian Institute of Science, Bangalore-560012.
Patil
Satish
S
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000737:chemistry; D001881:Borates / Q000737:chemistry*; D003460:Crystallization / Q000379:methods*; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods; D005947:Glucose / Q000737:chemistry*; D008422:Materials Testing
D000970:Antineoplastic Agents; D001881:Borates; D004337:Drug Carriers; D004317:Doxorubicin; D005947:Glucose