title: Application of aluminum phthalocyanine nanoparticles for fluorescent diagnostics in dentistry and skin autotransplantology.
abstract: This paper deals with the possibility of application of aluminum phthalocyanine (AlPc) nanoparticles in clinical practice. AlPc fluoresces in the molecular form but in the form of nanoparticles it does not. Separation of molecules from an AlPc nanoparticle and therefore the appearance of fluorescence occurs under the effect of a number of biochemo-physical factors. Owing to this feature the application of AlPc nanoparticles followed by the measurement of fluorescence spectra is proposed as a diagnostics method. It was shown that after AlPc nanoparticle application on a tooth surface the fluorescence intensity in the enamel microdamage area is 2-3 times higher than that in the normal enamel area. The appearance of fluorescence after application of AlPc nanoparticles on skin autografts testifies to the presence of inflammation.
authors.affiliation: Natural Sciences Center of AM Prokhorov General Physics Institute, Russian Academy of Sciences, Moscow, Russia. vas_serg@inbox.ru
authors.forename: Sergey Yu
authors.initials: SY
authors.lastname: Vasilchenko
authors.forename: Anna I
authors.initials: AI
authors.lastname: Volkova
authors.forename: Anastasiya V
authors.initials: AV
authors.lastname: Ryabova
authors.forename: Victor B
authors.initials: VB
authors.lastname: Loschenov
authors.forename: Vitaly I
authors.initials: VI
authors.lastname: Konov
authors.forename: Adil A
authors.initials: AA
authors.lastname: Mamedov
authors.forename: Sergey G
authors.initials: SG
authors.lastname: Kuzmin
authors.forename: Evgeniy A
authors.initials: EA
authors.lastname: Lukyanets
mesh_terms: D000818:Animals; D003102:Colloids / Q000737:chemistry; D003743:Dental Enamel / Q000473:pathology*; D003813:Dentistry / Q000379:methods*; D062109:Dermatologic Surgical Procedures; D005260:Female; D005453:Fluorescence; D006084:Graft Rejection / Q000175:diagnosis*; D006801:Humans; D066298:In Vitro Techniques; D007211:Indoles / Q000737:chemistry; D007249:Inflammation / Q000175:diagnosis; D008027:Light; D053768:Metal Nanoparticles / Q000737:chemistry; D051379:Mice; D009942:Organometallic Compounds / Q000737:chemistry; D012307:Risk Factors; D012542:Scattering, Radiation; D012867:Skin / Q000473:pathology; D016038:Skin Transplantation; D012996:Solutions; D013050:Spectrometry, Fluorescence; D013997:Time Factors; D014182:Transplantation, Autologous
chemical_list: D003102:Colloids; D007211:Indoles; D009942:Organometallic Compounds; D012996:Solutions; C060570:aluminum phthalocyanine