[Clinicopathological significance of CD137L expression in laryngeal carcinoma].
OBJECTIVE
To study the expression of CD137L in laryngeal carcinoma, and to analyze its clinicopathological significance.


METHODS
The expression of CD137L in 50 laryngeal carcinoma specimens and 9 normal laryngeal mucous tissues were detected by immunohistochemical staining.


RESULTS
The positive CD137L staining were found in all 50 cases of laryngeal carcinomas (100%), while its staining were negative in normal laryngeal mucous. There was significant difference between two groups (P < 0.01). The positive ratio of CD137L staining had no relationship with the factors such as age, sex and tumor site, while it had significant correlation with the pathological stage, T stage and lymph node metastasis.


CONCLUSIONS
The expression of CD137L might play an important role in the development of laryngeal carcinomas.
Li
Xiaoming
X
Department of Otolaryngology-Head and Neck Surgery, Bethune International Peace Hospital, Shijiazhuang, 050082, China. xml_968@sohu.com
Lu
Xiuying
X
Chen
Yinghui
Y
D053330:4-1BB Ligand / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis
D053330:4-1BB Ligand