title: Real-time monitoring of cellular responses to carbon nanotubes.
abstract: Dynamic cellular responses to carbon nanotubes were monitored by a real-time cell electronic sensing assay. This approach is based on the parallel impedance measurement of attached cells using electronic sensors integrated in wells of 96-well E-plate. It measures the real-time multiparameter index of cell growth named cell index (CI), which reflects the cell proliferation, morphology, attachment, and spreading. The label-free, real-time, and high-throughput assay overcomes many drawbacks in current optical based cytotoxicity assays in carbon nanotubes research, and enables dynamic monitoring of cellular responses to carbon nanotubes.
authors.affiliation: School of Chemistry and Chemical Engineering, Shandong University, Jinan, P. R. China.
authors.forename: Qingxin
authors.initials: Q
authors.lastname: Mu
authors.forename: Shumei
authors.initials: S
authors.lastname: Zhai
authors.forename: Bing
authors.initials: B
authors.lastname: Yan
mesh_terms: D015374:Biosensing Techniques; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D055664:Electrochemical Techniques; D004566:Electrodes; D006801:Humans; D037742:Nanotubes, Carbon / Q000737:chemistry / Q000633:toxicity*; D013997:Time Factors
chemical_list: D037742:Nanotubes, Carbon