title: Trichloroacetic acid in urine as biological exposure equivalent for low exposure concentrations of trichloroethene.
abstract: A urinary trichloroacetic acid (TCA) concentration of 100 mg/l at the end of the last work shift (8 h/day, 5 days/week) of the week has been established in workers as exposure equivalent for the carcinogenic substance trichloroethene (EKA for TRI) at an exposure concentration of 50 ppm TRI. Due to the continuous reduction of atmospheric TRI concentrations during the last years, the quantitative relation given by the EKA for TRI is revised for exposures to low TRI concentrations. A physiological two-compartment model is presented by which the urinary TCA concentrations are calculated that result from inhaled TRI in humans. The model contains one compartment for trichloroethanol (TCE) and one for TCA. Inhaled TRI is metabolized to TCA and to TCE. The latter is in part further oxidized to TCA. Urinary elimination of TCA is modeled to obey first order kinetics. All required model parameters were taken form the literature. In order to evaluate the model performance on the urinary TCA excretion at low exposure concentrations, predicted urinary TCA concentrations were compared with data obtained in two volunteer studies and in one field study. The model was evaluated at exposure concentrations as low as 12.5 ppm TRI. It is demonstrated that the correlation described by the hitherto used EKA for TRI is also valid at low TRI concentrations. For TRI exposure concentrations of 0.6 and 6 ppm, the resulting urinary TCA concentrations at the end of the last work shift of a week are predicted to be 1.2 and 12 mg/l, respectively.
authors.affiliation: Institute of Toxicology, Helmholtz Zentrum München, Ingolstädter Landstrasse 1, 85764 Neuherberg, Germany.
authors.forename: György A
authors.initials: GA
authors.lastname: Csanády
authors.forename: Thomas
authors.initials: T
authors.lastname: Göen
authors.forename: Dominik
authors.initials: D
authors.lastname: Klein
authors.forename: Hans
authors.initials: H
authors.lastname: Drexler
authors.forename: Johannes G
authors.initials: JG
authors.lastname: Filser
mesh_terms: D000395:Air Pollutants, Occupational / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis; D008954:Models, Biological; D016273:Occupational Exposure / Q000032:analysis*; D014238:Trichloroacetic Acid / Q000652:urine*; D014241:Trichloroethylene / Q000032:analysis / Q000378:metabolism*
chemical_list: D000395:Air Pollutants, Occupational; D014241:Trichloroethylene; D014238:Trichloroacetic Acid