title: 8-Oxo-7,8-dihydro-2'-deoxyguanosine produces a long-lived charge-separated state during the photosensitized one-electron oxidation of DNA resulting in efficient and exclusive degradation.
abstract: The kinetics and efficiency of oxidative degradation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodGuo) in DNA during the photosensitized one-electron oxidation of DNA was investigated. The presence of 8-oxodGuo was shown to increase the lifetime of the charge-separated state in DNA by serving as a "hole sink" resulting in efficient and exclusive degradation.
authors.affiliation: The Institute of Scientific and Industrial Research (SANKEN), Osaka University, Mihogaoka 8-1, Ibaraki, Osaka 567-0047, Japan. kiyohiko@sanken.osaka-u.ac.jp
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Kawai
authors.forename: Eri
authors.initials: E
authors.lastname: Matsutani
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Majima
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA / Q000737:chemistry*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000737:chemistry; D004583:Electrons; D007700:Kinetics; D010084:Oxidation-Reduction; D010777:Photochemistry; D017319:Photosensitizing Agents / Q000737:chemistry*
chemical_list: D017319:Photosensitizing Agents; D000080242:8-Hydroxy-2'-Deoxyguanosine; D004247:DNA; D003849:Deoxyguanosine