title: Individual progression of carotid intima media thickness as a surrogate for vascular risk (PROG-IMT): Rationale and design of a meta-analysis project.
abstract: Carotid intima media thickness (IMT) progression is increasingly used as a surrogate for vascular risk. This use is supported by data from a few clinical trials investigating statins, but established criteria of surrogacy are only partially fulfilled. To provide a valid basis for the use of IMT progression as a study end point, we are performing a 3-step meta-analysis project based on individual participant data. Objectives of the 3 successive stages are to investigate (1) whether IMT progression prospectively predicts myocardial infarction, stroke, or death in population-based samples; (2) whether it does so in prevalent disease cohorts; and (3) whether interventions affecting IMT progression predict a therapeutic effect on clinical end points. Recruitment strategies, inclusion criteria, and estimates of the expected numbers of eligible studies are presented along with a detailed analysis plan.
authors.affiliation: Department of Neurology, University Hospital, Goethe-University, Frankfurt am Main, Germany. matthias.lorenz@em.uni-frankfurt.de
authors.forename: Matthias W
authors.initials: MW
authors.lastname: Lorenz
authors.forename: Horst
authors.initials: H
authors.lastname: Bickel
authors.forename: Michiel L
authors.initials: ML
authors.lastname: Bots
authors.forename: Monique M B
authors.initials: MM
authors.lastname: Breteler
authors.forename: Alberico L
authors.initials: AL
authors.lastname: Catapano
authors.forename: Moise
authors.initials: M
authors.lastname: Desvarieux
authors.forename: Bo
authors.initials: B
authors.lastname: Hedblad
authors.forename: Bernhard
authors.initials: B
authors.lastname: Iglseder
authors.forename: Stein Harald
authors.initials: SH
authors.lastname: Johnsen
authors.forename: Michal
authors.initials: M
authors.lastname: Juraska
authors.forename: Stefan
authors.initials: S
authors.lastname: Kiechl
authors.forename: Ellisiv B
authors.initials: EB
authors.lastname: Mathiesen
authors.forename: Giuseppe D
authors.initials: GD
authors.lastname: Norata
authors.forename: Liliana
authors.initials: L
authors.lastname: Grigore
authors.forename: Joseph
authors.initials: J
authors.lastname: Polak
authors.forename: Holger
authors.initials: H
authors.lastname: Poppert
authors.forename: Maria
authors.initials: M
authors.lastname: Rosvall
authors.forename: Tatjana
authors.initials: T
authors.lastname: Rundek
authors.forename: Ralph L
authors.initials: RL
authors.lastname: Sacco
authors.forename: Dirk
authors.initials: D
authors.lastname: Sander
authors.forename: Matthias
authors.initials: M
authors.lastname: Sitzer
authors.forename: Helmuth
authors.initials: H
authors.lastname: Steinmetz
authors.forename: Eva
authors.initials: E
authors.lastname: Stensland
authors.forename: Johann
authors.initials: J
authors.lastname: Willeit
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Witteman
authors.forename: David
authors.initials: D
authors.lastname: Yanez
authors.forename: Simon G
authors.initials: SG
authors.lastname: Thompson
mesh_terms: D002339:Carotid Arteries / Q000473:pathology*; D002340:Carotid Artery Diseases / Q000453:epidemiology; D006801:Humans; D015201:Meta-Analysis as Topic; D015337:Multicenter Studies as Topic; D009203:Myocardial Infarction / Q000453:epidemiology; D011237:Predictive Value of Tests; D012107:Research Design; D018570:Risk Assessment / Q000379:methods*; D020521:Stroke / Q000453:epidemiology; D017539:Tunica Intima / Q000473:pathology*