Fas and FasL polymorphisms are not associated with acute myeloid leukemia risk in Koreans.
Fas and Fas ligand (FasL) polymorphisms in the promoter regions influence transcriptional activities. The interaction of these two genes plays a crucial role in apoptotic cell death regulation. They have been associated with esophageal, lung, uterine cervical, and urinary bladder cancers in human. We performed a case-control study to investigate the association between Fas and FasL polymorphisms and acute myeloid leukemia (AML) risk. Fas−1377G>A (rs2234767), −670T>C (rs1800682), and FasL−844T>C (rs763110) polymorphisms in 592 AML patients and 858 healthy controls were genotyped and tested for associations between polymorphisms and AML risk. There were no significant differences in genotypic and haplotypic distributions and gene-gene interaction between patients and controls in the overall analysis (p>0.05). These results suggested that polymorphisms of Fas and FasL genes were not associated with AML risk in the Korean population.
Kim
Hyun Jeong
HJ
Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun-gun, Chonnam, Republic of Korea.
Jin
Xue Mei
XM
Kim
Hee-Nam
HN
Lee
Il-Kwon
IK
Park
Kyeong-Soo
KS
Park
Moo Rim
MR
Jo
Deog Yeon
DY
Won
Jong Ho
JH
Kwak
Jae-Yong
JY
Kim
Hyeoung-Joon
HJ
Choi
Jin-Su
JS
Juhng
Sang Woo
SW
Choi
Chan
C
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D053222:Fas Ligand Protein / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007723:Korea; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012306:Risk; D019014:fas Receptor / Q000235:genetics*
D053222:Fas Ligand Protein; D019014:fas Receptor