Emerging roles of PDGF-D signaling pathway in tumor development and progression.
Platelet-derived growth factor-D (PDGF-D) can regulate many cellular processes, including cell proliferation, apoptosis, transformation, migration, invasion, angiogenesis and metastasis. Therefore PDGF-D signaling has been considered to be important in human malignancies, and thus PDGF-D signaling may represent a novel therapeutic target, and as such suggests that the development of agents that will target PDGF-D signaling is likely to have a significant therapeutic impact on human cancers. This mini-review describes the mechanisms of signal transduction associated with PDGF-D signaling to support the role of PDGF-D in the carcinogenesis. Moreover, we summarize data on several PDGF-D inhibitors especially naturally occurring "chemopreventive agent" such an indole compound, which we believe could serve as a novel agent for the prevention of tumor progression and/or treatment of human malignancies by targeted inactivation of PDGF-D signaling.
Wang
Zhiwei
Z
Department of Pathology, Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, MI 48201, USA. zhiweiwang@med.wayne.edu
Ahmad
Aamir
A
Li
Yiwei
Y
Kong
Dejuan
D
Azmi
Asfar S
AS
Banerjee
Sanjeev
S
Sarkar
Fazlul H
FH
D000818:Animals; D049109:Cell Proliferation; D002470:Cell Survival; D018450:Disease Progression; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D053583:Interleukin-1beta / Q000502:physiology; D008222:Lymphokines / Q000502:physiology*; D008648:Mesoderm / Q000473:pathology; D035683:MicroRNAs / Q000502:physiology; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology; D010982:Platelet-Derived Growth Factor / Q000502:physiology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D014568:Urokinase-Type Plasminogen Activator / Q000502:physiology
D053583:Interleukin-1beta; D008222:Lymphokines; D035683:MicroRNAs; C427493:PDGFD protein, human; D010982:Platelet-Derived Growth Factor; D017382:Reactive Oxygen Species; D014568:Urokinase-Type Plasminogen Activator