Novel Tween 20 derivatives enable the formation of efficient pH-sensitive drug delivery vehicles for human hepatoblastoma.
We describe the synthesis, the physicochemical characterization and the biological evaluation of three novel pH-sensitive systems prepared derivatizing polysorbate 20 (Tween 20) with glycine, N-methyl-glycine and N,N-dimethyl-glycine (TW20-GLY, TW20-MMG and TW20-DMG). These derivatives form pH-sensitive vesicles and translocate small molecules into cells. The reported systems are efficient drug delivery systems for human hepatoblastoma cells.
Masotti
Andrea
A
Gene Expression-Microarrays Laboratory, IRCCS-Children's Hospital Bambino Gesù, 00165 Rome, Italy. andrea.masotti@opbg.net
Vicennati
Paola
P
Alisi
Anna
A
Marianecci
Carlotta
C
Rinaldi
Federica
F
Carafa
Maria
M
Ortaggi
Giancarlo
G
D004337:Drug Carriers; D005998:Glycine / Q000737:chemistry; D018197:Hepatoblastoma / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008113:Liver Neoplasms / Q000378:metabolism*; D011136:Polysorbates / Q000008:administration & dosage / Q000737:chemistry*; D012521:Sarcosine / Q000031:analogs & derivatives / Q000737:chemistry; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D004337:Drug Carriers; D011136:Polysorbates; D013501:Surface-Active Agents; C025138:dimethylglycine; D005998:Glycine; D012521:Sarcosine