New dirhodium complex with activity towards colorectal cancer.
A novel dirhodium complex (Rh(2)(L-PheAla)(2)(OAc)(2) is reported with strong activity towards human colon adenocarcinoma cells. Its effect was not accompanied by generation of reactive oxygen species (ROS) neither by activation of caspase-3.
Frade
Raquel F M
RF
CQFM-Centro de Química-Física Molecular and IN-Institute of Nanosciences and Nanotechnology, Instituto Superior Técnico, Av. Rovisco Pais, 1049-001 Lisboa, Portugal. raquel.frade@ist.utl.pt
Candeias
Nuno R
NR
Duarte
Catarina M M
CM
André
Vânia
V
Duarte
M Teresa
MT
Gois
Pedro M P
PM
Afonso
Carlos A M
CA
D000230:Adenocarcinoma / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D053148:Caspase 3 / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D004789:Enzyme Activation; D006801:Humans; D017382:Reactive Oxygen Species / Q000378:metabolism; D012238:Rhodium / Q000494:pharmacology*
D017382:Reactive Oxygen Species; D012238:Rhodium; D053148:Caspase 3