The control of kainic acid-induced status epilepticus.
In the present study the effectiveness of different diazepam-ketamine combinations to control kainic acid-induced status epilepticus in rats was evaluated. We show that electrographic monitoring is mandatory to enable reliable assessment of status epilepticus control as the number of false positives is extremely high when status epilepticus control is only behaviourally assessed. Diazepam and ketamine synergistically blocked all electrographical seizure activity.
Vermoesen
Katia
K
Department of Pharmaceutical Chemistry and Drug Analysis, Research Group Experimental Pharmacology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels, Belgium.
Smolders
Ilse
I
Massie
Ann
A
Michotte
Yvette
Y
Clinckers
Ralph
R
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D003975:Diazepam / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004569:Electroencephalography / Q000379:methods; D018691:Excitatory Amino Acid Antagonists / Q000627:therapeutic use*; D007608:Kainic Acid; D007649:Ketamine / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013226:Status Epilepticus / Q000139:chemically induced / Q000188:drug therapy*
D000927:Anticonvulsants; D018691:Excitatory Amino Acid Antagonists; D007649:Ketamine; D003975:Diazepam; D007608:Kainic Acid